Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
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int64
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int64
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Localized detection of rapidly evolving Ca2+ release domains was attained by stage displacement of muscle fibers with respect to a stationary two-photon illumination spot.
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
171
37,116
0
false
Localized detection of rapidly evolving Ca2+ release domains was attained by stage displacement of muscle fibers with respect to a stationary two-photon illumination spot.
[]
Localized detection of rapidly evolving Ca2+ release domains was attained by stage displacement of muscle fibers with respect to a stationary two-photon illumination spot.
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This method relies on the fact that AP-evoked Ca2+ release is a robustly reproducible process (Escobar et al., 1994; Vergara et al., 2001; DiFranco et al., 2002).
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
162
37,117
0
false
This method relies on the fact that AP-evoked Ca2+ release is a robustly reproducible process.
[ "Escobar et al., 1994; Vergara et al., 2001; DiFranco et al., 2002" ]
This method relies on the fact that AP-evoked Ca2+ release is a robustly reproducible process.
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Furthermore, it demands a complete arrest of fiber shortening in order to avoid distortions in the position-dependent recording of localized Ca2+ transients.
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
157
37,118
0
false
Furthermore, it demands a complete arrest of fiber shortening in order to avoid distortions in the position-dependent recording of localized Ca2+ transients.
[]
Furthermore, it demands a complete arrest of fiber shortening in order to avoid distortions in the position-dependent recording of localized Ca2+ transients.
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
In the current study, we used millimolar
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
40
37,119
0
false
In the current study, we used millimolar
[]
In the current study, we used millimolar
true
true
false
true
false
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
[EGTA]s in the internal solution, which are known to constrain the free myoplasmic [Ca2+] changes to narrow regions circumscribing Ca2+ release (or entry) sites (Pape et al., 1995; DiGregorio et al., 1999; Novo et al., 2003).
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
225
37,120
0
false
[EGTA]s in the internal solution, which are known to constrain the free myoplasmic [Ca2+] changes to narrow regions circumscribing Ca2+ release (or entry) sites.
[ "Pape et al., 1995; DiGregorio et al., 1999; Novo et al., 2003" ]
s in the internal solution, which are known to constrain the free myoplasmic changes to narrow regions circumscribing Ca2+ release sites.
false
true
true
true
false
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
As expected, we found that 10 mM [EGTA] fully blocks AP-evoked movement in intact dissociated FDB fibers kept at slack length.
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
126
37,121
0
false
As expected, we found that 10 mM [EGTA] fully blocks AP-evoked movement in intact dissociated FDB fibers kept at slack length.
[]
As expected, we found that 10 mM fully blocks AP-evoked movement in intact dissociated FDB fibers kept at slack length.
true
true
true
true
true
6,370
1
DISCUSSION
1
Cheung et al., 2002
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
When 5 mM [EGTA] was used, 100 μM BTS (Cheung et al., 2002) was added to the external Tyrode solution to completely arrest fiber movement, as previously demonstrated (Woods et al., 2004).
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
187
37,122
1
false
When 5 mM [EGTA] was used, 100 μM BTS was added to the external Tyrode solution to completely arrest fiber movement, as previously demonstrated.
[ "Cheung et al., 2002", "Woods et al., 2004" ]
When 5 mM [EGTA] was used, 100 μM BTS was added to the external Tyrode solution to completely arrest fiber movement, as previously demonstrated.
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Since OGB-5N is a fast tracking Ca2+ indicator which, when used in conjunction with 10 mM EGTA, reports accurately the underlying Ca2+ release flux (Song et al., 1998; Woods et al., 2004), it is possible to infer that transients recorded at the center of the Ca2+ release domains (T-transients) are representative wavefo...
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
407
37,123
0
false
Since OGB-5N is a fast tracking Ca2+ indicator which, when used in conjunction with 10 mM EGTA, reports accurately the underlying Ca2+ release flux, it is possible to infer that transients recorded at the center of the Ca2+ release domains (T-transients) are representative waveforms for the AP-evoked physiological proc...
[ "Song et al., 1998; Woods et al., 2004" ]
Since OGB-5N is a fast tracking Ca2+ indicator which, when used in conjunction with 10 mM EGTA, reports accurately the underlying Ca2+ release flux, it is possible to infer that transients recorded at the center of the Ca2+ release domains are representative waveforms for the AP-evoked physiological process of Ca2+ rel...
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Interestingly, the FDHM of T-transients at room temperature is 1.45 ± 0.08 ms (Table I), which is even shorter than that of the AP itself (∼2 ms, Fig.
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
150
37,124
0
false
Interestingly, the FDHM of T-transients at room temperature is 1.45 ± 0.08 ms (Table I), which is even shorter than that of the AP itself (∼2 ms, Fig.
[]
Interestingly, the FDHM of T-transients at room temperature is 1.45 ± 0.08 ms, which is even shorter than that of the AP itself (∼2 ms, Fig.
true
true
true
true
true
6,370
1
DISCUSSION
1
Escobar et al., 1994
[ "bib17", "bib47", "bib12", "bib38", "bib13", "bib37", "bib7", "bib50", "bib43", "bib50", "bib49" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
3; also see Woods et al., 2005).
[ "Escobar et al., 1994", "Vergara et al., 2001", "DiFranco et al., 2002", "Pape et al., 1995", "DiGregorio et al., 1999", "Novo et al., 2003", "Cheung et al., 2002", "Woods et al., 2004", "Song et al., 1998", "Woods et al., 2004", "Woods et al., 2005" ]
32
37,125
0
false
3; also see Woods et al., 2005).
[]
3; also see Woods et al., 2005).
false
false
true
true
false
6,370
2
DISCUSSION
0
null
null
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Our finding that under similar conditions the amplitude of global transients is comparable to that of T-transients, and not smaller, as expected for signals reporting average values of the Ca2+ distribution along the sarcomere is puzzling.
null
239
37,126
0
false
null
null
Our finding that under similar conditions the amplitude of global transients is comparable to that of T-transients, and not smaller, as expected for signals reporting average values of the Ca2+ distribution along the sarcomere is puzzling.
true
true
true
true
true
6,371
2
DISCUSSION
0
null
null
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
A possible explanation is that global transients, recorded from an ample volume of the muscle fiber, might contain contributions from triads capable of larger Ca2+ release than those probed with the TPSpD system.
null
212
37,127
0
false
null
null
A possible explanation is that global transients, recorded from an ample volume of the muscle fiber, might contain contributions from triads capable of larger Ca2+ release than those probed with the TPSpD system.
true
true
true
true
true
6,371
2
DISCUSSION
0
null
null
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This is compatible with the a priori choice, in these latter experiments, to scan the spot only within the medial axial plane of the fiber.
null
139
37,128
0
false
null
null
This is compatible with the a priori choice, in these latter experiments, to scan the spot only within the medial axial plane of the fiber.
true
true
true
true
true
6,371
2
DISCUSSION
0
null
null
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The implications of these results can, and will be, investigated in the future.
null
79
37,129
0
false
null
null
The implications of these results can, and will be, investigated in the future.
true
true
true
true
true
6,371
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
The comparison of [Ca2+] changes at different locations is based on the accurate calculation of ΔF/F at each site (see Materials and Methods).
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
142
37,130
0
false
The comparison of [Ca2+] changes at different locations is based on the accurate calculation of ΔF/F at each site (see Materials and Methods).
[]
The comparison of changes at different locations is based on the accurate calculation of ΔF/F at each site.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
This calculation is in turn based on the realistic assumption that at any location, the fluorescence before stimulation (at resting state) represents the concentration of OGB-5N molecules capable of readily binding Ca2+ions; as a consequence, smaller ΔF/Fs at one location represent reduced [Ca2+] changes at that site.
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
319
37,131
0
false
This calculation is in turn based on the realistic assumption that at any location, the fluorescence before stimulation (at resting state) represents the concentration of OGB-5N molecules capable of readily binding Ca2+ions; as a consequence, smaller ΔF/Fs at one location represent reduced [Ca2+] changes at that site.
[]
This calculation is in turn based on the realistic assumption that at any location, the fluorescence before stimulation represents the concentration of OGB-5N molecules capable of readily binding Ca2+ions; as a consequence, smaller ΔF/Fs at one location represent reduced changes at that site.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
Bearing this in mind, the presence of a band of higher resting fluorescence colocalized with the Z-line has been supposed to reflect an increased dye concentration at that location, probably resulting from dye binding to proteins specific to this region (e.g., α-actinin).
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
272
37,132
0
false
Bearing this in mind, the presence of a band of higher resting fluorescence colocalized with the Z-line has been supposed to reflect an increased dye concentration at that location, probably resulting from dye binding to proteins specific to this region (e.g., α-actinin).
[]
Bearing this in mind, the presence of a band of higher resting fluorescence colocalized with the Z-line has been supposed to reflect an increased dye concentration at that location, probably resulting from dye binding to proteins specific to this region.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
Thus, we inferred that the reduced ΔF/F at the Z-line truly reflected smaller [Ca2+] changes there.
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
99
37,133
0
false
Thus, we inferred that the reduced ΔF/F at the Z-line truly reflected smaller [Ca2+] changes there.
[]
Thus, we inferred that the reduced ΔF/F at the Z-line truly reflected smaller changes there.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
A caveat to this result is that the association of selected Ca2+ indicators with representative myoplasmic proteins has been reported to decrease their Ca2+ binding affinity (Hove-Madsen and Bers, 1992; Harkins et al., 1993), a possibility that can result in reduced ΔF/F transients for similar [Ca2+] changes.
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
310
37,134
0
false
A caveat to this result is that the association of selected Ca2+ indicators with representative myoplasmic proteins has been reported to decrease their Ca2+ binding affinity, a possibility that can result in reduced ΔF/F transients for similar [Ca2+] changes.
[ "Hove-Madsen and Bers, 1992; Harkins et al., 1993" ]
A caveat to this result is that the association of selected Ca2+ indicators with representative myoplasmic proteins has been reported to decrease their Ca2+ binding affinity, a possibility that can result in reduced ΔF/F transients for similar changes.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
Nevertheless, we have verified, using methods similar to those of the latter authors, that the Ca2+ binding affinity of OGB-5N is either not altered or increased in the presence of large concentrations (up to 80 mg/ml) of albumin and creatine phosphokinase, respectively (unpublished data).
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
290
37,135
0
false
Nevertheless, we have verified, using methods similar to those of the latter authors, that the Ca2+ binding affinity of OGB-5N is either not altered or increased in the presence of large concentrations (up to 80 mg/ml) of albumin and creatine phosphokinase, respectively (unpublished data).
[]
Nevertheless, we have verified, using methods similar to those of the latter authors, that the Ca2+ binding affinity of OGB-5N is either not altered or increased in the presence of large concentrations of albumin and creatine phosphokinase, respectively.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
An alternative caution is the possibility that the Ca2+ dye might get trapped inside the mitochondria, which are known to be clustered around the Z-lines, and give an artificially high level of fluorescence.
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
207
37,136
0
false
An alternative caution is the possibility that the Ca2+ dye might get trapped inside the mitochondria, which are known to be clustered around the Z-lines, and give an artificially high level of fluorescence.
[]
An alternative caution is the possibility that the Ca2+ dye might get trapped inside the mitochondria, which are known to be clustered around the Z-lines, and give an artificially high level of fluorescence.
true
true
true
true
true
6,372
3
DISCUSSION
1
Hove-Madsen and Bers, 1992
[ "bib27", "bib25" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA
If this were the case, our ΔF/F calculations would be underestimated at these locations, leading to an exacerbation of the valleys between adjacent Ca2+ sources.
[ "Hove-Madsen and Bers, 1992", "Harkins et al., 1993" ]
161
37,137
0
false
If this were the case, our ΔF/F calculations would be underestimated at these locations, leading to an exacerbation of the valleys between adjacent Ca2+ sources.
[]
If this were the case, our ΔF/F calculations would be underestimated at these locations, leading to an exacerbation of the valleys between adjacent Ca2+ sources.
true
true
true
true
true
6,372
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
A critical question answered in these studies is the colocalization of the Ca2+ release sites with respect to anatomical structures in mammalian skeletal muscle fibers.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
168
37,138
0
false
A critical question answered in these studies is the colocalization of the Ca2+ release sites with respect to anatomical structures in mammalian skeletal muscle fibers.
[]
A critical question answered in these studies is the colocalization of the Ca2+ release sites with respect to anatomical structures in mammalian skeletal muscle fibers.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
We used di-8-ANEPPS, a nonpenetrating potentiometric dye, to specifically label the T-tubules, which are the central component of the triads.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
141
37,139
0
false
We used di-8-ANEPPS, a nonpenetrating potentiometric dye, to specifically label the T-tubules, which are the central component of the triads.
[]
We used di-8-ANEPPS, a nonpenetrating potentiometric dye, to specifically label the T-tubules, which are the central component of the triads.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The di-8-ANEPPS fluorescence images (Fig.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
41
37,140
0
false
The di-8-ANEPPS fluorescence images (Fig.
[]
The di-8-ANEPPS fluorescence images (Fig.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
2 B) showed double row of T-tubules per sarcomere, a distinctive feature of mammalian skeletal muscle fibers that has been documented previously (Revel, 1962; Franzini-Armstrong et al., 1988; Dulhunty, 1989; Lannergren et al., 1999; DiFranco et al., 2005; Woods et al., 2005).
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
276
37,141
0
false
2 B) showed double row of T-tubules per sarcomere, a distinctive feature of mammalian skeletal muscle fibers that has been documented previously.
[ "Revel, 1962; Franzini-Armstrong et al., 1988; Dulhunty, 1989; Lannergren et al., 1999; DiFranco et al., 2005; Woods et al., 2005" ]
2 B) showed double row of T-tubules per sarcomere, a distinctive feature of mammalian skeletal muscle fibers that has been documented previously.
false
false
true
true
false
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This is consistent with electron microscopy evidence showing that triads in unstretched mammalian fibers are located at both sides of the Z-line at the I-A junction region of the sarcomere (Revel, 1962; Franzini-Armstrong et al., 1988; Dulhunty, 1989).
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
252
37,142
0
false
This is consistent with electron microscopy evidence showing that triads in unstretched mammalian fibers are located at both sides of the Z-line at the I-A junction region of the sarcomere.
[ "Revel, 1962; Franzini-Armstrong et al., 1988; Dulhunty, 1989" ]
This is consistent with electron microscopy evidence showing that triads in unstretched mammalian fibers are located at both sides of the Z-line at the I-A junction region of the sarcomere.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
We investigated here the exact sarcomeric colocalization of Ca2+ domains with the T-tubules by dual staining fibers with di-8-ANEPPS and OGB-5N and verified that the central position of Ca2+ domains coincides with the peak of the di-8-ANEPPS bands (Fig.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
253
37,143
0
false
We investigated here the exact sarcomeric colocalization of Ca2+ domains with the T-tubules by dual staining fibers with di-8-ANEPPS and OGB-5N and verified that the central position of Ca2+ domains coincides with the peak of the di-8-ANEPPS bands (Fig.
[]
We investigated here the exact sarcomeric colocalization of Ca2+ domains with the T-tubules by dual staining fibers with di-8-ANEPPS and OGB-5N and verified that the central position of Ca2+ domains coincides with the peak of the di-8-ANEPPS bands (Fig.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
In fact, we found that it was not necessary to perform every Ca2+ domain measurement in dual stained fibers because the resting distribution of OGB-5N fluorescence, by showing a clear peak at the Z-line (Fig.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
208
37,144
0
false
In fact, we found that it was not necessary to perform every Ca2+ domain measurement in dual stained fibers because the resting distribution of OGB-5N fluorescence, by showing a clear peak at the Z-line (Fig.
[]
In fact, we found that it was not necessary to perform every Ca2+ domain measurement in dual stained fibers because the resting distribution of OGB-5N fluorescence, by showing a clear peak at the Z-line (Fig.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
2, C–F), provided an alternative anatomical reference.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
54
37,145
0
false
2, C–F), provided an alternative anatomical reference.
[]
2, C–F), provided an alternative anatomical reference.
false
false
true
true
false
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Consequently, although the majority of the experimental data were obtained from fibers stained with OGB-5N alone (Figs.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
119
37,146
0
false
Consequently, although the majority of the experimental data were obtained from fibers stained with OGB-5N alone (Figs.
[]
Consequently, although the majority of the experimental data were obtained from fibers stained with OGB-5N alone (Figs.
true
true
true
true
true
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
3–6 and Table I), the position dependence of Ca2+ transients always relied on the precise determination of the Z-line position (Figs.
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
135
37,147
0
false
3–6 and Table I), the position dependence of Ca2+ transients always relied on the precise determination of the Z-line position (Figs.
[]
3–6 and Table I), the position dependence of Ca2+ transients always relied on the precise determination of the Z-line position (Figs.
false
false
true
true
false
6,373
4
DISCUSSION
1
Revel, 1962
[ "bib40", "bib22", "bib15", "bib33", "bib10", "bib49", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
4, 5, and 7).
[ "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989", "Lannergren et al., 1999", "DiFranco et al., 2005", "Woods et al., 2005", "Revel, 1962", "Franzini-Armstrong et al., 1988", "Dulhunty, 1989" ]
13
37,148
0
false
4, 5, and 7).
[]
4, 5, and 7).
false
false
true
true
false
6,373
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The single-peaked pattern reported here for the resting OGB-5N fluorescence in mammalian fibers (Fig.
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
101
37,149
0
false
The single-peaked pattern reported here for the resting OGB-5N fluorescence in mammalian fibers (Fig.
[]
The single-peaked pattern reported here for the resting OGB-5N fluorescence in mammalian fibers (Fig.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
2) is different than the double banded pattern observed in frog fibers, where a wide band was centered at the M-line and a much thinner peak at the Z-line (Vergara et al., 2001; DiFranco et al., 2002).
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
201
37,150
0
false
2) is different than the double banded pattern observed in frog fibers, where a wide band was centered at the M-line and a much thinner peak at the Z-line.
[ "Vergara et al., 2001; DiFranco et al., 2002" ]
2) is different than the double banded pattern observed in frog fibers, where a wide band was centered at the M-line and a much thinner peak at the Z-line.
false
false
true
true
false
6,374
5
DISCUSSION
1
Shirokova et al., 1998
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Interestingly, the OGB-5N distribution in frog fibers was similar to that found for Fluo-3 (Tsugorka et al., 1995; Klein et al., 1996; Hollingworth et al., 2000), a correspondence between dyes that is seemingly maintained for mammalian fibers (Shirokova et al., 1998).
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
268
37,151
1
false
Interestingly, the OGB-5N distribution in frog fibers was similar to that found for Fluo-3, a correspondence between dyes that is seemingly maintained for mammalian fibers.
[ "Tsugorka et al., 1995; Klein et al., 1996; Hollingworth et al., 2000", "Shirokova et al., 1998" ]
Interestingly, the OGB-5N distribution in frog fibers was similar to that found for Fluo-3, a correspondence between dyes that is seemingly maintained for mammalian fibers.
true
true
true
true
true
6,374
5
DISCUSSION
1
Kirsch et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
However, it has been suggested that the single Fluo-4 fluorescence bands observed in skinned mammalian fibers were centered at the M-lines (Kirsch et al., 2001).
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
161
37,152
1
false
However, it has been suggested that the single Fluo-4 fluorescence bands observed in skinned mammalian fibers were centered at the M-lines.
[ "Kirsch et al., 2001" ]
However, it has been suggested that the single Fluo-4 fluorescence bands observed in skinned mammalian fibers were centered at the M-lines.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This is surprising given the similarity between Fluo-3 and Fluo-4, which is greater than that between OGB-5N and Fluo-3.
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
120
37,153
0
false
This is surprising given the similarity between Fluo-3 and Fluo-4, which is greater than that between OGB-5N and Fluo-3.
[]
This is surprising given the similarity between Fluo-3 and Fluo-4, which is greater than that between OGB-5N and Fluo-3.
true
true
true
true
true
6,374
5
DISCUSSION
1
Kirsch et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
What is important is that these authors (Kirsch et al., 2001) used the M-line as a reference point to infer that the location of dual sites of elementary release were off-centered with respect to Z-lines; notably, their reference point could have been reversed.
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
261
37,154
1
false
What is important is that these authors used the M-line as a reference point to infer that the location of dual sites of elementary release were off-centered with respect to Z-lines; notably, their reference point could have been reversed.
[ "Kirsch et al., 2001" ]
What is important is that these authors used the M-line as a reference point to infer that the location of dual sites of elementary release were off-centered with respect to Z-lines; notably, their reference point could have been reversed.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Our data clearly demonstrate that AP-evoked Ca2+ release domains are symmetrically located flanking the resting OGB-5N peaks (Z-lines) and that the shortest center-to-center distance between domains (∼1 μm) is comparable to the TSZ value measured with di-8-ANEPPS (∼0.8 μm) but significantly smaller than the TSM distanc...
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
350
37,155
0
false
Our data clearly demonstrate that AP-evoked Ca2+ release domains are symmetrically located flanking the resting OGB-5N peaks (Z-lines) and that the shortest center-to-center distance between domains (∼1 μm) is comparable to the TSZ value measured with di-8-ANEPPS (∼0.8 μm) but significantly smaller than the TSM distanc...
[]
Our data clearly demonstrate that AP-evoked Ca2+ release domains are symmetrically located flanking the resting OGB-5N peaks and that the shortest center-to-center distance between domains is comparable to the TSZ value measured with di-8-ANEPPS but significantly smaller than the TSM distance across the M-line.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This is appealing because, even in unstretched mammalian muscle fibers, it is possible to observe (Fig.
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
103
37,156
0
false
This is appealing because, even in unstretched mammalian muscle fibers, it is possible to observe (Fig.
[]
This is appealing because, even in unstretched mammalian muscle fibers, it is possible to observe (Fig.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
4) an asymmetrical pattern in which pairs of domains flanking the Z-lines are closer to each other than pairs across the M-lines.
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
129
37,157
0
false
4) an asymmetrical pattern in which pairs of domains flanking the Z-lines are closer to each other than pairs across the M-lines.
[]
4) an asymmetrical pattern in which pairs of domains flanking the Z-lines are closer to each other than pairs across the M-lines.
false
false
true
true
false
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This pattern is markedly different than that observed in amphibian muscle fibers where the domains are evenly spaced along the fiber axis with a spacing identical to the SL of the fiber (Escobar et al., 1994; Hollingworth et al., 2000; Vergara et al., 2001; DiFranco et al., 2002).
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
281
37,158
0
false
This pattern is markedly different than that observed in amphibian muscle fibers where the domains are evenly spaced along the fiber axis with a spacing identical to the SL of the fiber.
[ "Escobar et al., 1994; Hollingworth et al., 2000; Vergara et al., 2001; DiFranco et al., 2002" ]
This pattern is markedly different than that observed in amphibian muscle fibers where the domains are evenly spaced along the fiber axis with a spacing identical to the SL of the fiber.
true
true
true
true
true
6,374
5
DISCUSSION
1
Vergara et al., 2001
[ "bib47", "bib12", "bib44", "bib31", "bib26", "bib42", "bib30", "bib30", "bib17", "bib26", "bib47", "bib12", "bib39", "bib52", "bib40", "bib22", "bib15" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Most notably, by putting together the results reported here with previous amphibian data we may conclude that functional Ca2+ release domains in both taxa (mammals and amphibians) are uniquely centered where the triads are observed with electron microscopy, namely at the Z-lines in frog fibers (Peachey, 1965; Zampighi ...
[ "Vergara et al., 2001", "DiFranco et al., 2002", "Tsugorka et al., 1995", "Klein et al., 1996", "Hollingworth et al., 2000", "Shirokova et al., 1998", "Kirsch et al., 2001", "Kirsch et al., 2001", "Escobar et al., 1994", "Hollingworth et al., 2000", "Vergara et al., 2001", "DiFranco et al., 20...
465
37,159
0
false
Most notably, by putting together the results reported here with previous amphibian data we may conclude that functional Ca2+ release domains in both taxa (mammals and amphibians) are uniquely centered where the triads are observed with electron microscopy, namely at the Z-lines in frog fibers, and in off-centered pair...
[ "Peachey, 1965; Zampighi et al., 1975", "Revel, 1962; Franzini-Armstrong et al., 1988; Dulhunty, 1989" ]
Most notably, by putting together the results reported here with previous amphibian data we may conclude that functional Ca2+ release domains in both taxa are uniquely centered where the triads are observed with electron microscopy, namely at the Z-lines in frog fibers, and in off-centered pairs flanking the Z-lines in...
true
true
true
true
true
6,374
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
We have recently demonstrated in mammalian fibers stained with di-8-ANEPPS that lengthening the sarcomeres by stretch results in increases of TSM without changing TSZ significantly (DiFranco et al., 2005, 2006).
[ "DiFranco et al., 2005", "2006" ]
211
37,160
0
false
We have recently demonstrated in mammalian fibers stained with di-8-ANEPPS that lengthening the sarcomeres by stretch results in increases of TSM without changing TSZ significantly.
[ "DiFranco et al., 2005, 2006" ]
We have recently demonstrated in mammalian fibers stained with di-8-ANEPPS that lengthening the sarcomeres by stretch results in increases of TSM without changing TSZ significantly.
true
true
true
true
true
6,375
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
Thus, it could be predicted that stretching would segregate the pairs of Ca2+ release domains away from regions of actomyosin overlapping, an effect possibly contributing to mechanical uncoupling.
[ "DiFranco et al., 2005", "2006" ]
196
37,161
0
false
Thus, it could be predicted that stretching would segregate the pairs of Ca2+ release domains away from regions of actomyosin overlapping, an effect possibly contributing to mechanical uncoupling.
[]
Thus, it could be predicted that stretching would segregate the pairs of Ca2+ release domains away from regions of actomyosin overlapping, an effect possibly contributing to mechanical uncoupling.
true
true
true
true
true
6,375
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
Preliminarily data obtained with single-photon confocal microscopy (Vergara et al., 2002) support this contention.
[ "DiFranco et al., 2005", "2006" ]
114
37,162
0
false
Preliminarily data obtained with single-photon confocal microscopy (Vergara et al., 2002) support this contention.
[]
Preliminarily data obtained with single-photon confocal microscopy support this contention.
true
true
true
true
true
6,375
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
We are currently extending these studies by using TPSpD and mathematical modeling to investigate whether spatial segregation of Ca2+ release sites, afforded by different degrees of stretching, significantly alters the sarcomeric Ca2+ distribution.
[ "DiFranco et al., 2005", "2006" ]
247
37,163
0
false
We are currently extending these studies by using TPSpD and mathematical modeling to investigate whether spatial segregation of Ca2+ release sites, afforded by different degrees of stretching, significantly alters the sarcomeric Ca2+ distribution.
[]
We are currently extending these studies by using TPSpD and mathematical modeling to investigate whether spatial segregation of Ca2+ release sites, afforded by different degrees of stretching, significantly alters the sarcomeric Ca2+ distribution.
true
true
true
true
true
6,375
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
Furthermore, to date we have found no evidence that the Ca2+ release domains are systematically skewed in a way compatible with the contention that there are intrinsic asymmetries in SR release sites.
[ "DiFranco et al., 2005", "2006" ]
200
37,164
0
false
Furthermore, to date we have found no evidence that the Ca2+ release domains are systematically skewed in a way compatible with the contention that there are intrinsic asymmetries in SR release sites.
[]
Furthermore, to date we have found no evidence that the Ca2+ release domains are systematically skewed in a way compatible with the contention that there are intrinsic asymmetries in SR release sites.
true
true
true
true
true
6,375
6
DISCUSSION
1
DiFranco et al., 2005
[ "bib10", "bib11" ]
16,735,751
NA|NA
Nevertheless, this is an open question, which would require a higher optical resolution to be answered.
[ "DiFranco et al., 2005", "2006" ]
103
37,165
0
false
Nevertheless, this is an open question, which would require a higher optical resolution to be answered.
[]
Nevertheless, this is an open question, which would require a higher optical resolution to be answered.
true
true
true
true
true
6,375
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
Although in vitro bead calibrations showed that the lateral resolution of the two-photon system is ∼0.4 μm, we observed the FWHM of stained T-tubules to be ∼0.6 μm.
[ "Revel, 1962", "Revel, 1962" ]
164
37,166
0
false
Although in vitro bead calibrations showed that the lateral resolution of the two-photon system is ∼0.4 μm, we observed the FWHM of stained T-tubules to be ∼0.6 μm.
[]
Although in vitro bead calibrations showed that the lateral resolution of the two-photon system is ∼0.4 μm, we observed the FWHM of stained T-tubules to be ∼0.6 μm.
true
true
true
true
true
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
This discrepancy is important; given their elliptical cross section with a long diameter of <50 nm (Revel, 1962), they should have been reported as blurred objects with an FWHM of ∼0.4 μm.
[ "Revel, 1962", "Revel, 1962" ]
188
37,167
1
false
This discrepancy is important; given their elliptical cross section with a long diameter of <50 nm, they should have been reported as blurred objects with an FWHM of ∼0.4 μm.
[ "Revel, 1962" ]
This discrepancy is important; given their elliptical cross section with a long diameter of <50 nm, they should have been reported as blurred objects with an FWHM of ∼0.4 μm.
true
true
true
true
true
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
A plausible reason for the divergence arises from the tortuous geometry of the T-system as illustrated by electron micrographs of mammalian fibers in which the T-tubules wander at regions of the sarcomere flanking the Z-line (AI bands) in an apparently random fashion (e.g., see Fig.
[ "Revel, 1962", "Revel, 1962" ]
283
37,168
0
false
A plausible reason for the divergence arises from the tortuous geometry of the T-system as illustrated by electron micrographs of mammalian fibers in which the T-tubules wander at regions of the sarcomere flanking the Z-line (AI bands) in an apparently random fashion (e.g., see Fig.
[]
A plausible reason for the divergence arises from the tortuous geometry of the T-system as illustrated by electron micrographs of mammalian fibers in which the T-tubules wander at regions of the sarcomere flanking the Z-line in an apparently random fashion (e.g., see Fig.
true
true
true
true
true
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
4 in Revel, 1962).
[ "Revel, 1962", "Revel, 1962" ]
18
37,169
0
false
4 in Revel, 1962).
[]
4 in Revel, 1962).
false
false
true
true
false
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
Thus, in our case the T-tubules could fold back and forth hundreds of nanometers within the spot.
[ "Revel, 1962", "Revel, 1962" ]
97
37,170
0
false
Thus, in our case the T-tubules could fold back and forth hundreds of nanometers within the spot.
[]
Thus, in our case the T-tubules could fold back and forth hundreds of nanometers within the spot.
true
true
true
true
true
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
It is also possible that the fiber represents an anisotropic and complex optical media, which could alter the point-spread function of the microscope.
[ "Revel, 1962", "Revel, 1962" ]
150
37,171
0
false
It is also possible that the fiber represents an anisotropic and complex optical media, which could alter the point-spread function of the microscope.
[]
It is also possible that the fiber represents an anisotropic and complex optical media, which could alter the point-spread function of the microscope.
true
true
true
true
true
6,376
7
DISCUSSION
1
Revel, 1962
[ "bib40", "bib40" ]
16,735,751
NA|NA
Nevertheless, in vitro bead calibrations in sucrose-agar solutions were not different from those in water (unpublished data).
[ "Revel, 1962", "Revel, 1962" ]
125
37,172
0
false
Nevertheless, in vitro bead calibrations in sucrose-agar solutions were not different from those in water (unpublished data).
[]
Nevertheless, in vitro bead calibrations in sucrose-agar solutions were not different from those in water.
true
true
true
true
true
6,376
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The T-tubule measurements have important meaning for the estimation of the actual width of the Ca2+ release domains observed with 10 mM internal
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
144
37,173
0
false
The T-tubule measurements have important meaning for the estimation of the actual width of the Ca2+ release domains observed with 10 mM internal
[]
The T-tubule measurements have important meaning for the estimation of the actual width of the Ca2+ release domains observed with 10 mM internal
true
true
false
true
false
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Namely, the ∼0.6 μm FWHM sets a practical lower limit for how small functional Ca2+ release sources would be observed with the two-photon spot system.
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
150
37,174
0
false
Namely, the ∼0.6 μm FWHM sets a practical lower limit for how small functional Ca2+ release sources would be observed with the two-photon spot system.
[]
Namely, the ∼0.6 μm FWHM sets a practical lower limit for how small functional Ca2+ release sources would be observed with the two-photon spot system.
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
It is interesting to note that the FWHM of Ca2+ release domains measured early during the rising phase of the individual Ca2+ transients was also ∼0.6 μm (Fig.
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
159
37,175
0
false
It is interesting to note that the FWHM of Ca2+ release domains measured early during the rising phase of the individual Ca2+ transients was also ∼0.6 μm (Fig.
[]
It is interesting to note that the FWHM of Ca2+ release domains measured early during the rising phase of the individual Ca2+ transients was also ∼0.6 μm (Fig.
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
5, A and C).
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
12
37,176
0
false
5, A and C).
[]
5, A and C).
false
false
true
true
false
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Taken together, these results show that in adult mammalian fibers the Ca2+ release sources are probably confined to the T-tubules' location.
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
140
37,177
0
false
Taken together, these results show that in adult mammalian fibers the Ca2+ release sources are probably confined to the T-tubules' location.
[]
Taken together, these results show that in adult mammalian fibers the Ca2+ release sources are probably confined to the T-tubules' location.
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
This is reinforced by the observation that the Ca2+ release domains did not expand significantly in time (Fig.
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
110
37,178
0
false
This is reinforced by the observation that the Ca2+ release domains did not expand significantly in time (Fig.
[]
This is reinforced by the observation that the Ca2+ release domains did not expand significantly in time (Fig.
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
5 C), as it would be expected in the presence of high [EGTA], due to the constraining effect of this chelator on the size of Ca2+ release domains around the Ca2+ release source (Pape et al., 1995; Neher, 1998; DiGregorio et al., 1999; Novo et al., 2003).
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
254
37,179
0
false
5 C), as it would be expected in the presence of high [EGTA], due to the constraining effect of this chelator on the size of Ca2+ release domains around the Ca2+ release source.
[ "Pape et al., 1995; Neher, 1998; DiGregorio et al., 1999; Novo et al., 2003" ]
5 C), as it would be expected in the presence of high [EGTA], due to the constraining effect of this chelator on the size of Ca2+ release domains around the Ca2+ release source.
false
false
true
true
false
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
These results are compatible with the strict localization of RyR1 at the junctional SR and the absence of Ca2+ release channels at extrajunctional regions of the SR in mammalian fibers (Flucher and Franzini-Armstrong, 1996;
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
223
37,180
0
false
These results are compatible with the strict localization of RyR1 at the junctional SR and the absence of Ca2+ release channels at extrajunctional regions of the SR in mammalian fibers (Flucher and Franzini-Armstrong, 1996;
[]
These results are compatible with the strict localization of RyR1 at the junctional SR and the absence of Ca2+ release channels at extrajunctional regions of the SR in mammalian fibers (Flucher and Franzini-Armstrong, 1996;
true
true
false
true
false
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
Felder and Franzini-Armstrong, 2002).
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
37
37,181
0
false
Felder and Franzini-Armstrong, 2002).
[]
Felder and Franzini-Armstrong, 2002).
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
The situation is different than what was found in amphibian muscle fibers where Ca2+ domains are centered at the T-tubules, but displays broader distributions than what is expected for junctional SR (Vergara et al., 2001; DiFranco et al., 2002; Novo et al., 2003).
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
264
37,182
0
false
The situation is different than what was found in amphibian muscle fibers where Ca2+ domains are centered at the T-tubules, but displays broader distributions than what is expected for junctional SR.
[ "Vergara et al., 2001; DiFranco et al., 2002; Novo et al., 2003" ]
The situation is different than what was found in amphibian muscle fibers where Ca2+ domains are centered at the T-tubules, but displays broader distributions than what is expected for junctional SR.
true
true
true
true
true
6,377
8
DISCUSSION
1
Pape et al., 1995
[ "bib38", "bib35", "bib13", "bib37", "bib20", "bib19", "bib47", "bib12", "bib37", "bib16", "bib19" ]
16,735,751
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
These latter results were explained on the basis of a broad release region encompassing the entire terminal cisternae of the SR, as purportedly supported by the presence of extrajunctional Ca2+ release channels (RyRβ) in this preparation (Dulhunty et al., 1992; Felder and Franzini-Armstrong, 2002).
[ "Pape et al., 1995", "Neher, 1998", "DiGregorio et al., 1999", "Novo et al., 2003", "Flucher and Franzini-Armstrong, 1996", "Felder and Franzini-Armstrong, 2002", "Vergara et al., 2001", "DiFranco et al., 2002", "Novo et al., 2003", "Dulhunty et al., 1992", "Felder and Franzini-Armstrong, 2002" ...
299
37,183
0
false
These latter results were explained on the basis of a broad release region encompassing the entire terminal cisternae of the SR, as purportedly supported by the presence of extrajunctional Ca2+ release channels (RyRβ) in this preparation.
[ "Dulhunty et al., 1992; Felder and Franzini-Armstrong, 2002" ]
These latter results were explained on the basis of a broad release region encompassing the entire terminal cisternae of the SR, as purportedly supported by the presence of extrajunctional Ca2+ release channels (RyRβ) in this preparation.
true
true
true
true
true
6,377
9
DISCUSSION
1
Shirokova et al., 1998
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
In contrast to the case of amphibian muscle fibers, calcium sparks are not physiological events in mammalian skeletal muscle fibers (Shirokova et al., 1998).
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
157
37,184
1
false
In contrast to the case of amphibian muscle fibers, calcium sparks are not physiological events in mammalian skeletal muscle fibers.
[ "Shirokova et al., 1998" ]
In contrast to the case of amphibian muscle fibers, calcium sparks are not physiological events in mammalian skeletal muscle fibers.
true
true
true
true
true
6,378
9
DISCUSSION
1
Shirokova et al., 1998
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
They are detectable only under nonphysiological conditions, e.g., when the sarcolemma is removed and the fibers are exposed to “intracellular” SO4 2−-based solutions (Kirsch et al., 2001; Zhou et al., 2003).
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
207
37,185
0
false
They are detectable only under nonphysiological conditions, e.g., when the sarcolemma is removed and the fibers are exposed to “intracellular” SO4 2−-based solutions.
[ "Kirsch et al., 2001; Zhou et al., 2003" ]
They are detectable only under nonphysiological conditions, e.g., when the sarcolemma is removed and the fibers are exposed to “intracellular” SO4 2−-based solutions.
true
true
true
true
true
6,378
9
DISCUSSION
1
Zhou et al., 2003
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
Under these circumstances, mammalian sparks have been reported to be long lasting events lasting up to 60 ms, with a spatially broad distribution (2–5 μm width) spanning at least a full sarcomere (Zhou et al., 2003).
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
216
37,186
1
false
Under these circumstances, mammalian sparks have been reported to be long lasting events lasting up to 60 ms, with a spatially broad distribution (2–5 μm width) spanning at least a full sarcomere.
[ "Zhou et al., 2003" ]
Under these circumstances, mammalian sparks have been reported to be long lasting events lasting up to 60 ms, with a spatially broad distribution spanning at least a full sarcomere.
true
true
true
true
true
6,378
9
DISCUSSION
1
Shirokova et al., 1998
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
Furthermore, evidence demonstrating clear colocalization of the center of the sparks with the triad(s) involved in their generation is lacking.
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
143
37,187
0
false
Furthermore, evidence demonstrating clear colocalization of the center of the sparks with the triad(s) involved in their generation is lacking.
[]
Furthermore, evidence demonstrating clear colocalization of the center of the sparks with the triad(s) involved in their generation is lacking.
true
true
true
true
true
6,378
9
DISCUSSION
1
Shirokova et al., 1998
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
Consequently, it is difficult to directly compare the properties of spark events recorded in such disparate conditions with AP-evoked Ca2+ release domains that are formed and dissipate within ∼10 ms, as reported here under quasi-physiological conditions.
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
254
37,188
0
false
Consequently, it is difficult to directly compare the properties of spark events recorded in such disparate conditions with AP-evoked Ca2+ release domains that are formed and dissipate within ∼10 ms, as reported here under quasi-physiological conditions.
[]
Consequently, it is difficult to directly compare the properties of spark events recorded in such disparate conditions with AP-evoked Ca2+ release domains that are formed and dissipate within ∼10 ms, as reported here under quasi-physiological conditions.
true
true
true
true
true
6,378
9
DISCUSSION
1
Shirokova et al., 1998
[ "bib42", "bib30", "bib53", "bib53" ]
16,735,751
NA|NA|NA|NA
Nevertheless, the results reported in this paper allow us to realistically state that mammalian Ca2+ sparks, with properties like those reported in the past, are not good candidates to be considered as unitary events underlying the Ca2+ release process at the triads in response to AP stimulation.
[ "Shirokova et al., 1998", "Kirsch et al., 2001", "Zhou et al., 2003", "Zhou et al., 2003" ]
297
37,189
0
false
Nevertheless, the results reported in this paper allow us to realistically state that mammalian Ca2+ sparks, with properties like those reported in the past, are not good candidates to be considered as unitary events underlying the Ca2+ release process at the triads in response to AP stimulation.
[]
Nevertheless, the results reported in this paper allow us to realistically state that mammalian Ca2+ sparks, with properties like those reported in the past, are not good candidates to be considered as unitary events underlying the Ca2+ release process at the triads in response to AP stimulation.
true
true
true
true
true
6,378
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
Recruitment within the hepatic microvasculature is an exception to the classical recruitment paradigm in that neutrophils are sequestered not only in venules but also in sinusoidal capillaries.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
193
37,190
0
false
Recruitment within the hepatic microvasculature is an exception to the classical recruitment paradigm in that neutrophils are sequestered not only in venules but also in sinusoidal capillaries.
[]
Recruitment within the hepatic microvasculature is an exception to the classical recruitment paradigm in that neutrophils are sequestered not only in venules but also in sinusoidal capillaries.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
Moreover, accumulation of neutrophils in the sinusoids is independent of the selectins known to mediate neutrophil recruitment in tissues such as muscle, mesentery, and skin (8–10, 13, 16).
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
189
37,191
0
false
Moreover, accumulation of neutrophils in the sinusoids is independent of the selectins known to mediate neutrophil recruitment in tissues such as muscle, mesentery, and skin.
[ "8–10, 13, 16" ]
Moreover, accumulation of neutrophils in the sinusoids is independent of the selectins known to mediate neutrophil recruitment in tissues such as muscle, mesentery, and skin.
true
true
true
true
true
6,379
0
DISCUSSION
1
40
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
In fact, the prevailing view has been that disseminated release of inflammatory mediators during endotoxemia or sepsis causes increased rigidity of activated neutrophils, causing them to become mechanically lodged in prohibitively small sinusoids (40).
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
252
37,192
1
false
In fact, the prevailing view has been that disseminated release of inflammatory mediators during endotoxemia or sepsis causes increased rigidity of activated neutrophils, causing them to become mechanically lodged in prohibitively small sinusoids.
[ "40" ]
In fact, the prevailing view has been that disseminated release of inflammatory mediators during endotoxemia or sepsis causes increased rigidity of activated neutrophils, causing them to become mechanically lodged in prohibitively small sinusoids.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
In this study, we have demonstrated for the first time that CD44 and its principal ligand HA are intimately involved in the sequestration of neutrophils in the liver sinusoids.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
176
37,193
0
false
In this study, we have demonstrated for the first time that CD44 and its principal ligand HA are intimately involved in the sequestration of neutrophils in the liver sinusoids.
[]
In this study, we have demonstrated for the first time that CD44 and its principal ligand HA are intimately involved in the sequestration of neutrophils in the liver sinusoids.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
Although CD44 has previously been shown to mediate some lymphocyte and neutrophil adhesion, there was always overlapping contributions by other molecules including selectins and integrins, and the mechanism was never dependent exclusively on CD44 (25, 26, 41, 42).
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
264
37,194
0
false
Although CD44 has previously been shown to mediate some lymphocyte and neutrophil adhesion, there was always overlapping contributions by other molecules including selectins and integrins, and the mechanism was never dependent exclusively on CD44.
[ "25, 26, 41, 42" ]
Although CD44 has previously been shown to mediate some lymphocyte and neutrophil adhesion, there was always overlapping contributions by other molecules including selectins and integrins, and the mechanism was never dependent exclusively on CD44.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
In fact, Nandi et al.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
21
37,195
0
false
In fact, Nandi et al.
[]
In fact, Nandi et al.
true
true
true
true
true
6,379
0
DISCUSSION
1
25
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
(25) demonstrated a clear overlap between CD44 and α4 integrin, which was manifested as a physical colocalization of the two molecules.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
135
37,196
1
false
demonstrated a clear overlap between CD44 and α4 integrin, which was manifested as a physical colocalization of the two molecules.
[ "25" ]
demonstrated a clear overlap between CD44 and α4 integrin, which was manifested as a physical colocalization of the two molecules.
false
true
true
true
false
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
However, our data in the liver suggested that CD44-mediated adhesion of neutrophils was independent of selectins, α4 and β2 integrins, as well as other receptors such as RHAMM and VAP-1, as none of these molecules supported sinusoidal neutrophil adhesion alone or as coadhesion receptors with CD44.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
298
37,197
0
false
However, our data in the liver suggested that CD44-mediated adhesion of neutrophils was independent of selectins, α4 and β2 integrins, as well as other receptors such as RHAMM and VAP-1, as none of these molecules supported sinusoidal neutrophil adhesion alone or as coadhesion receptors with CD44.
[]
However, our data in the liver suggested that CD44-mediated adhesion of neutrophils was independent of selectins, α4 and β2 integrins, as well as other receptors such as RHAMM and VAP-1, as none of these molecules supported sinusoidal neutrophil adhesion alone or as coadhesion receptors with CD44.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
Moreover, anti-CD44 antibody was sufficient to block and even reverse adhesion in liver sinusoids, suggesting exclusive adhesion via CD44 in those adherent neutrophils that detached.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
182
37,198
0
false
Moreover, anti-CD44 antibody was sufficient to block and even reverse adhesion in liver sinusoids, suggesting exclusive adhesion via CD44 in those adherent neutrophils that detached.
[]
Moreover, anti-CD44 antibody was sufficient to block and even reverse adhesion in liver sinusoids, suggesting exclusive adhesion via CD44 in those adherent neutrophils that detached.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
Much like the liver, extremely high numbers of neutrophils bind within capillary vessels of the lungs during sepsis and endotoxemia.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
132
37,199
0
false
Much like the liver, extremely high numbers of neutrophils bind within capillary vessels of the lungs during sepsis and endotoxemia.
[]
Much like the liver, extremely high numbers of neutrophils bind within capillary vessels of the lungs during sepsis and endotoxemia.
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
However, in contrast to the liver, HA expression was modest within the lungs, and coincidentally neutrophils still homed to the lungs of CD44−/− animals (unpublished data).
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
172
37,200
0
false
However, in contrast to the liver, HA expression was modest within the lungs, and coincidentally neutrophils still homed to the lungs of CD44−/− animals (unpublished data).
[]
However, in contrast to the liver, HA expression was modest within the lungs, and coincidentally neutrophils still homed to the lungs of CD44−/− animals (unpublished data).
true
true
true
true
true
6,379
0
DISCUSSION
1
8
[ "bib8", "bib10", "bib13", "bib16", "bib40", "bib25", "bib26", "bib41", "bib42", "bib25" ]
18,362,172
pmid-7530761|pmid-7524368|pmid-9169509|pmid-10796888|pmid-1376747|pmid-15084274|pmid-16497973|pmid-15585887|pmid-9381175|pmid-15084274
This indicates that CD44–HA interactions may be a liver-specific paradigm of neutrophil recruitment during systemic inflammation.
[ "8", "10", "13", "16", "40", "25", "26", "41", "42", "25" ]
129
37,201
0
false
This indicates that CD44–HA interactions may be a liver-specific paradigm of neutrophil recruitment during systemic inflammation.
[]
This indicates that CD44–HA interactions may be a liver-specific paradigm of neutrophil recruitment during systemic inflammation.
true
true
true
true
true
6,379
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
A general biopanning screen for adhesion molecule expression levels drew our attention to the known adhesion molecule HA as a potential contributor to molecular adhesion of neutrophils to sinusoidal endothelium during endotoxemia.
[ "43", "44", "45" ]
230
37,202
0
false
A general biopanning screen for adhesion molecule expression levels drew our attention to the known adhesion molecule HA as a potential contributor to molecular adhesion of neutrophils to sinusoidal endothelium during endotoxemia.
[]
A general biopanning screen for adhesion molecule expression levels drew our attention to the known adhesion molecule HA as a potential contributor to molecular adhesion of neutrophils to sinusoidal endothelium during endotoxemia.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
Significant numbers of neutrophils adhered in the liver within 30–60 min of i.v.
[ "43", "44", "45" ]
80
37,203
0
false
Significant numbers of neutrophils adhered in the liver within 30–60 min of i.v.
[]
Significant numbers of neutrophils adhered in the liver within 30–60 min of i.v.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
LPS injection (unpublished data), suggesting that the candidate adhesion molecule might be present on the endothelium under basal conditions.
[ "43", "44", "45" ]
141
37,204
0
false
LPS injection (unpublished data), suggesting that the candidate adhesion molecule might be present on the endothelium under basal conditions.
[]
LPS injection (unpublished data), suggesting that the candidate adhesion molecule might be present on the endothelium under basal conditions.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
This was certainly the case for HA, with levels under basal conditions being at least two orders of magnitude higher than in any other organ even after normalization for weight and vascular density.
[ "43", "44", "45" ]
198
37,205
0
false
This was certainly the case for HA, with levels under basal conditions being at least two orders of magnitude higher than in any other organ even after normalization for weight and vascular density.
[]
This was certainly the case for HA, with levels under basal conditions being at least two orders of magnitude higher than in any other organ even after normalization for weight and vascular density.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
In addition, spinning disk confocal microscopy revealed selective spatial distribution of HA on endothelial cells of sinusoids but not postsinusoidal venules.
[ "43", "44", "45" ]
158
37,206
0
false
In addition, spinning disk confocal microscopy revealed selective spatial distribution of HA on endothelial cells of sinusoids but not postsinusoidal venules.
[]
In addition, spinning disk confocal microscopy revealed selective spatial distribution of HA on endothelial cells of sinusoids but not postsinusoidal venules.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
This is in agreement with electron microscopy studies in both humans and rats that found HA selectively localized on the apical surface of the sinusoidal endothelium (43, 44).
[ "43", "44", "45" ]
175
37,207
0
false
This is in agreement with electron microscopy studies in both humans and rats that found HA selectively localized on the apical surface of the sinusoidal endothelium.
[ "43, 44" ]
This is in agreement with electron microscopy studies in both humans and rats that found HA selectively localized on the apical surface of the sinusoidal endothelium.
true
true
true
true
true
6,380
1
DISCUSSION
1
43
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
The constitutive attachment of HA to liver sinusoidal endothelium may be distinct from other vascular beds, as the liver functions as a scavenger of HA, continuously binding free HA in the circulation.
[ "43", "44", "45" ]
201
37,208
0
false
The constitutive attachment of HA to liver sinusoidal endothelium may be distinct from other vascular beds, as the liver functions as a scavenger of HA, continuously binding free HA in the circulation.
[]
The constitutive attachment of HA to liver sinusoidal endothelium may be distinct from other vascular beds, as the liver functions as a scavenger of HA, continuously binding free HA in the circulation.
true
true
true
true
true
6,380
1
DISCUSSION
1
45
[ "bib43", "bib44", "bib45" ]
18,362,172
pmid-10824885|pmid-9021714|pmid-9421471
Indeed, previous studies have reported that microvascular endothelium derived from other organs is not decorated with constitutive HA, and surface expression requires de novo synthesis during the inflammatory response (45).
[ "43", "44", "45" ]
223
37,209
1
false
Indeed, previous studies have reported that microvascular endothelium derived from other organs is not decorated with constitutive HA, and surface expression requires de novo synthesis during the inflammatory response.
[ "45" ]
Indeed, previous studies have reported that microvascular endothelium derived from other organs is not decorated with constitutive HA, and surface expression requires de novo synthesis during the inflammatory response.
true
true
true
true
true
6,380
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
Previous studies have reported that endothelial CD44 is required to present HA to leukocyte CD44 in a sandwich-like model (26, 41, 46).
[ "26", "41", "46", "47", "48" ]
135
37,210
0
false
Previous studies have reported that endothelial CD44 is required to present HA to leukocyte CD44 in a sandwich-like model.
[ "26, 41, 46" ]
Previous studies have reported that endothelial CD44 is required to present HA to leukocyte CD44 in a sandwich-like model.
true
true
true
true
true
6,381
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
Unexpectedly, using chimeric mice lacking CD44 on endothelium, we found that endothelial CD44 did not contribute significantly to the binding of HA to liver sinusoidal endothelium.
[ "26", "41", "46", "47", "48" ]
180
37,211
0
false
Unexpectedly, using chimeric mice lacking CD44 on endothelium, we found that endothelial CD44 did not contribute significantly to the binding of HA to liver sinusoidal endothelium.
[]
Unexpectedly, using chimeric mice lacking CD44 on endothelium, we found that endothelial CD44 did not contribute significantly to the binding of HA to liver sinusoidal endothelium.
true
true
true
true
true
6,381
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
Furthermore, an abundance of HA was observed in the sinusoids of CD44−/− mice.
[ "26", "41", "46", "47", "48" ]
78
37,212
0
false
Furthermore, an abundance of HA was observed in the sinusoids of CD44−/− mice.
[]
Furthermore, an abundance of HA was observed in the sinusoids of CD44−/− mice.
true
true
true
true
true
6,381
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
Other endothelial HA-binding receptors have been identified, particularly in the liver.
[ "26", "41", "46", "47", "48" ]
87
37,213
0
false
Other endothelial HA-binding receptors have been identified, particularly in the liver.
[]
Other endothelial HA-binding receptors have been identified, particularly in the liver.
true
true
true
true
true
6,381
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
For example, HA receptor for endocytosis (HARE, also designated stabilin-2, FEEL-2), involved in the clearance of HA from the circulation by liver sinusoidal endothelial cells, allows for HA to continuously accumulate on the surface of sinusoids (47, 48).
[ "26", "41", "46", "47", "48" ]
255
37,214
0
false
For example, HA receptor for endocytosis (HARE, also designated stabilin-2, FEEL-2), involved in the clearance of HA from the circulation by liver sinusoidal endothelial cells, allows for HA to continuously accumulate on the surface of sinusoids.
[ "47, 48" ]
For example, HA receptor for endocytosis, involved in the clearance of HA from the circulation by liver sinusoidal endothelial cells, allows for HA to continuously accumulate on the surface of sinusoids.
true
true
true
true
true
6,381
2
DISCUSSION
1
26
[ "bib26", "bib41", "bib46", "bib47", "bib48" ]
18,362,172
pmid-16497973|pmid-15585887|pmid-10809739|pmid-10952975|pmid-12645574
Therefore, HA is constitutively presented to CD44 on neutrophils circulating through the liver.
[ "26", "41", "46", "47", "48" ]
95
37,215
0
false
Therefore, HA is constitutively presented to CD44 on neutrophils circulating through the liver.
[]
Therefore, HA is constitutively presented to CD44 on neutrophils circulating through the liver.
true
true
true
true
true
6,381