Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
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 Community
1
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4
DISCUSSION
1
37
[ "B40", "B51", "B52", "B53", "B37" ]
20,562,439
pmid-15020582|pmid-11425866|pmid-14690611|pmid-15525516|pmid-17597150
Moreover, dissociation of (H2A-H2B) dimers has been detected in vitro by FRET over increased salt concentrations (37).
[ "40", "51", "52", "53", "37" ]
118
37,316
1
false
Moreover, dissociation of (H2A-H2B) dimers has been detected in vitro by FRET over increased salt concentrations.
[ "37" ]
Moreover, dissociation of (H2A-H2B) dimers has been detected in vitro by FRET over increased salt concentrations.
true
true
true
true
true
6,398
4
DISCUSSION
1
40
[ "B40", "B51", "B52", "B53", "B37" ]
20,562,439
pmid-15020582|pmid-11425866|pmid-14690611|pmid-15525516|pmid-17597150
Using this technique, we found that both UV irradiated NCPs and NCPs containing a single UV lesion are significantly less stable to salt-induced dissociation (Figs.
[ "40", "51", "52", "53", "37" ]
164
37,317
0
false
Using this technique, we found that both UV irradiated NCPs and NCPs containing a single UV lesion are significantly less stable to salt-induced dissociation (Figs.
[]
Using this technique, we found that both UV irradiated NCPs and NCPs containing a single UV lesion are significantly less stable to salt-induced dissociation (Figs.
true
true
true
true
true
6,398
4
DISCUSSION
1
40
[ "B40", "B51", "B52", "B53", "B37" ]
20,562,439
pmid-15020582|pmid-11425866|pmid-14690611|pmid-15525516|pmid-17597150
4, 6, D and E).
[ "40", "51", "52", "53", "37" ]
15
37,318
0
false
4, 6, D and E).
[]
4, 6, D and E).
false
false
true
true
false
6,398
4
DISCUSSION
1
40
[ "B40", "B51", "B52", "B53", "B37" ]
20,562,439
pmid-15020582|pmid-11425866|pmid-14690611|pmid-15525516|pmid-17597150
It is possible that, UV-damaged NCPs undergo conformational changes more easily, and/or preferentially release (H2A-H2B) dimers, with increased salt, both of which would facilitate DNA lesion access by repair proteins.
[ "40", "51", "52", "53", "37" ]
218
37,319
0
false
It is possible that, UV-damaged NCPs undergo conformational changes more easily, and/or preferentially release (H2A-H2B) dimers, with increased salt, both of which would facilitate DNA lesion access by repair proteins.
[]
It is possible that, UV-damaged NCPs undergo conformational changes more easily, and/or preferentially release (H2A-H2B) dimers, with increased salt, both of which would facilitate DNA lesion access by repair proteins.
true
true
true
true
true
6,398
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
Enhanced unwrapping of damaged nucleosomes may provide sufficient time for passive binding of repair proteins.
[ "54", "54" ]
110
37,320
0
false
Enhanced unwrapping of damaged nucleosomes may provide sufficient time for passive binding of repair proteins.
[]
Enhanced unwrapping of damaged nucleosomes may provide sufficient time for passive binding of repair proteins.
true
true
true
true
true
6,399
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
Indeed, Suter and Thoma have shown that the single-subunit protein, UV photolyase, is strongly inhibited by nucleosomes in vitro, yet is capable of gaining rapid access to CPDs in nucleosomes of intact yeast cells (54).
[ "54", "54" ]
219
37,321
1
false
Indeed, Suter and Thoma have shown that the single-subunit protein, UV photolyase, is strongly inhibited by nucleosomes in vitro, yet is capable of gaining rapid access to CPDs in nucleosomes of intact yeast cells.
[ "54" ]
Indeed, Suter and Thoma have shown that the single-subunit protein, UV photolyase, is strongly inhibited by nucleosomes in vitro, yet is capable of gaining rapid access to CPDs in nucleosomes of intact yeast cells.
true
true
true
true
true
6,399
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
Importantly, these authors found that repair rates are slower in the central regions of nucleosome DNA and faster near the terminal ends (54).
[ "54", "54" ]
142
37,322
1
false
Importantly, these authors found that repair rates are slower in the central regions of nucleosome DNA and faster near the terminal ends.
[ "54" ]
Importantly, these authors found that repair rates are slower in the central regions of nucleosome DNA and faster near the terminal ends.
true
true
true
true
true
6,399
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
These observations are consistent with the intrinsic site-exposure model and the dynamic enhancement of damaged nucleosomes yielding more time for UV photolyase proteins to recognize CPDs in chromatin.
[ "54", "54" ]
201
37,323
0
false
These observations are consistent with the intrinsic site-exposure model and the dynamic enhancement of damaged nucleosomes yielding more time for UV photolyase proteins to recognize CPDs in chromatin.
[]
These observations are consistent with the intrinsic site-exposure model and the dynamic enhancement of damaged nucleosomes yielding more time for UV photolyase proteins to recognize CPDs in chromatin.
true
true
true
true
true
6,399
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
Access and binding to nucleosomes by UV photolyase may be possible through the spontaneous “trapping” of partially unwrapped nucleosomes, in which the terminal DNA is transiently released from the histone surface.
[ "54", "54" ]
213
37,324
0
false
Access and binding to nucleosomes by UV photolyase may be possible through the spontaneous “trapping” of partially unwrapped nucleosomes, in which the terminal DNA is transiently released from the histone surface.
[]
Access and binding to nucleosomes by UV photolyase may be possible through the spontaneous “trapping” of partially unwrapped nucleosomes, in which the terminal DNA is transiently released from the histone surface.
true
true
true
true
true
6,399
5
DISCUSSION
1
54
[ "B54", "B54" ]
20,562,439
pmid-12051916|pmid-12051916
Thus, compared with nucleosome sliding or histone eviction, the site-exposure mechanism is a rapid, energy-efficient way for repair proteins to gain access to DNA lesions, at least near the ends of nucleosome DNA.
[ "54", "54" ]
213
37,325
0
false
Thus, compared with nucleosome sliding or histone eviction, the site-exposure mechanism is a rapid, energy-efficient way for repair proteins to gain access to DNA lesions, at least near the ends of nucleosome DNA.
[]
Thus, compared with nucleosome sliding or histone eviction, the site-exposure mechanism is a rapid, energy-efficient way for repair proteins to gain access to DNA lesions, at least near the ends of nucleosome DNA.
true
true
true
true
true
6,399
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
Nucleotide excision repair is the main pathway used in most organisms (including human) to repair UV lesions (5), and nucleosome rearrangements occur during nucleotide excision repair in chromatin (55, 56).
[ "5", "55", "56", "14", "20", "21", "5" ]
206
37,326
1
false
Nucleotide excision repair is the main pathway used in most organisms (including human) to repair UV lesions, and nucleosome rearrangements occur during nucleotide excision repair in chromatin.
[ "5", "55, 56" ]
Nucleotide excision repair is the main pathway used in most organisms (including human) to repair UV lesions, and nucleosome rearrangements occur during nucleotide excision repair in chromatin.
true
true
true
true
true
6,400
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
Furthermore, it has been shown that ATP-dependent chromatin remodeling factors and histone modification are involved in the DNA repair process (14, 20, 21).
[ "5", "55", "56", "14", "20", "21", "5" ]
156
37,327
0
false
Furthermore, it has been shown that ATP-dependent chromatin remodeling factors and histone modification are involved in the DNA repair process.
[ "14, 20, 21" ]
Furthermore, it has been shown that ATP-dependent chromatin remodeling factors and histone modification are involved in the DNA repair process.
true
true
true
true
true
6,400
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
However, it is unclear how these remodeling and modification factors are recruited to sites of damaged DNA associated with nucleosomes.
[ "5", "55", "56", "14", "20", "21", "5" ]
135
37,328
0
false
However, it is unclear how these remodeling and modification factors are recruited to sites of damaged DNA associated with nucleosomes.
[]
However, it is unclear how these remodeling and modification factors are recruited to sites of damaged DNA associated with nucleosomes.
true
true
true
true
true
6,400
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
Our data implies that intrinsic nucleosome dynamics, especially increased unwrapping of UV-damaged NCPs, facilitate the invasion of factors involved in repair and/or those involved in remodeling or histone modifications.
[ "5", "55", "56", "14", "20", "21", "5" ]
220
37,329
0
false
Our data implies that intrinsic nucleosome dynamics, especially increased unwrapping of UV-damaged NCPs, facilitate the invasion of factors involved in repair and/or those involved in remodeling or histone modifications.
[]
Our data implies that intrinsic nucleosome dynamics, especially increased unwrapping of UV-damaged NCPs, facilitate the invasion of factors involved in repair and/or those involved in remodeling or histone modifications.
true
true
true
true
true
6,400
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
The binding of damage specific factors should further shift the equilibrium toward the unwrapped states.
[ "5", "55", "56", "14", "20", "21", "5" ]
104
37,330
0
false
The binding of damage specific factors should further shift the equilibrium toward the unwrapped states.
[]
The binding of damage specific factors should further shift the equilibrium toward the unwrapped states.
true
true
true
true
true
6,400
6
DISCUSSION
1
5
[ "B5", "B55", "B56", "B14", "B20", "B21", "B5" ]
20,562,439
NA|pmid-279912|pmid-1892653|pmid-12637512|pmid-17013386|pmid-15939881|NA
Thus, once repair recognition factors and/or remodeling factors are recruited to the damaged nucleosomes, disruption of local chromatin structure could initiate the “cascade” of recruitment of nucleotide excision repair proteins (5).
[ "5", "55", "56", "14", "20", "21", "5" ]
233
37,331
1
false
Thus, once repair recognition factors and/or remodeling factors are recruited to the damaged nucleosomes, disruption of local chromatin structure could initiate the “cascade” of recruitment of nucleotide excision repair proteins.
[ "5" ]
Thus, once repair recognition factors and/or remodeling factors are recruited to the damaged nucleosomes, disruption of local chromatin structure could initiate the “cascade” of recruitment of nucleotide excision repair proteins.
true
true
true
true
true
6,400
0
INTRODUCTION
1
1
[ "DDQ002C1", "DDQ002C2", "DDQ002C3", "DDQ002C4", "DDQ002C5" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Mitochondria are essential, complex organelles of eukaryotic organisms required for a variety of metabolic processes including the generation of energy by oxidative phosphorylation (1).
[ "1", "2", "3", "4", "5" ]
185
37,332
1
false
Mitochondria are essential, complex organelles of eukaryotic organisms required for a variety of metabolic processes including the generation of energy by oxidative phosphorylation.
[ "1" ]
Mitochondria are essential, complex organelles of eukaryotic organisms required for a variety of metabolic processes including the generation of energy by oxidative phosphorylation.
true
true
true
true
true
6,401
0
INTRODUCTION
1
1
[ "DDQ002C1", "DDQ002C2", "DDQ002C3", "DDQ002C4", "DDQ002C5" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Normal mitochondrial function requires 500–2000 different types of proteins depending on the species.
[ "1", "2", "3", "4", "5" ]
101
37,333
0
false
Normal mitochondrial function requires 500–2000 different types of proteins depending on the species.
[]
Normal mitochondrial function requires 500–2000 different types of proteins depending on the species.
true
true
true
true
true
6,401
0
INTRODUCTION
1
1
[ "DDQ002C1", "DDQ002C2", "DDQ002C3", "DDQ002C4", "DDQ002C5" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
However, mitochondrial genome of yeast and human cells encodes only 8 and 13 proteins, respectively (2,3).
[ "1", "2", "3", "4", "5" ]
106
37,334
0
false
However, mitochondrial genome of yeast and human cells encodes only 8 and 13 proteins, respectively.
[ "2,3" ]
However, mitochondrial genome of yeast and human cells encodes only 8 and 13 proteins, respectively.
true
true
true
true
true
6,401
0
INTRODUCTION
1
1
[ "DDQ002C1", "DDQ002C2", "DDQ002C3", "DDQ002C4", "DDQ002C5" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Thus, the vast majority of proteins that comprise mitochondria are encoded by the nuclear genome and mitochondrial function requires the import and folding of a large number of proteins synthesized on cytosolic ribosomes (4,5).
[ "1", "2", "3", "4", "5" ]
227
37,335
0
false
Thus, the vast majority of proteins that comprise mitochondria are encoded by the nuclear genome and mitochondrial function requires the import and folding of a large number of proteins synthesized on cytosolic ribosomes.
[ "4,5" ]
Thus, the vast majority of proteins that comprise mitochondria are encoded by the nuclear genome and mitochondrial function requires the import and folding of a large number of proteins synthesized on cytosolic ribosomes.
true
true
true
true
true
6,401
1
INTRODUCTION
1
6
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Owing to distinct compartmentalization into an outer and inner membrane, mitochondria have evolved an efficient system for recognition and transport of precursor proteins across membranes.
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
188
37,336
0
false
Owing to distinct compartmentalization into an outer and inner membrane, mitochondria have evolved an efficient system for recognition and transport of precursor proteins across membranes.
[]
Owing to distinct compartmentalization into an outer and inner membrane, mitochondria have evolved an efficient system for recognition and transport of precursor proteins across membranes.
true
true
true
true
true
6,402
1
INTRODUCTION
1
6
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Import of nuclear encoded proteins into the mitochondrial membranes is a multistep process involving machinery of cytosol, mitochondrial membranes and mitochondrial matrix (6–10).
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
179
37,337
0
false
Import of nuclear encoded proteins into the mitochondrial membranes is a multistep process involving machinery of cytosol, mitochondrial membranes and mitochondrial matrix.
[ "6–10" ]
Import of nuclear encoded proteins into the mitochondrial membranes is a multistep process involving machinery of cytosol, mitochondrial membranes and mitochondrial matrix.
true
true
true
true
true
6,402
1
INTRODUCTION
1
6
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
As a first step in the translocation process, the cytosolic facing receptors recognize the mitochondrial targeting sequence of a precursor protein and transfer them to the protein complex of the outer membrane, where Tom40 forms a pore and allows passage of the precursor protein through the membrane (6,8,10).
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
310
37,338
0
false
As a first step in the translocation process, the cytosolic facing receptors recognize the mitochondrial targeting sequence of a precursor protein and transfer them to the protein complex of the outer membrane, where Tom40 forms a pore and allows passage of the precursor protein through the membrane.
[ "6,8,10" ]
As a first step in the translocation process, the cytosolic facing receptors recognize the mitochondrial targeting sequence of a precursor protein and transfer them to the protein complex of the outer membrane, where Tom40 forms a pore and allows passage of the precursor protein through the membrane.
true
true
true
true
true
6,402
1
INTRODUCTION
1
6
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
After passage through TOM complex, a major portion of precursor proteins are targeted into mitochondrial matrix; and this process is mediated by presequence translocase (TIM23 complex) of the inner membrane (7–10).
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
214
37,339
0
false
After passage through TOM complex, a major portion of precursor proteins are targeted into mitochondrial matrix; and this process is mediated by presequence translocase (TIM23 complex) of the inner membrane.
[ "7–10" ]
After passage through TOM complex, a major portion of precursor proteins are targeted into mitochondrial matrix; and this process is mediated by presequence translocase (TIM23 complex) of the inner membrane.
true
true
true
true
true
6,402
1
INTRODUCTION
1
13
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
The TIM23 complex consists mainly two set of components: (i) channel-forming components which include integral membrane proteins Tim23 and Tim17 that comprise the translocation channel (9,11,12) and (ii) the associated peripheral membrane protein Tim50 (13).
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
258
37,340
1
false
The TIM23 complex consists mainly two set of components: (i) channel-forming components which include integral membrane proteins Tim23 and Tim17 that comprise the translocation channel and (ii) the associated peripheral membrane protein Tim50.
[ "9,11,12", "13" ]
The TIM23 complex consists mainly two set of components: (i) channel-forming components which include integral membrane proteins Tim23 and Tim17 that comprise the translocation channel and (ii) the associated peripheral membrane protein Tim50.
true
true
true
true
true
6,402
1
INTRODUCTION
1
6
[ "DDQ002C6", "DDQ002C10", "DDQ002C6", "DDQ002C8", "DDQ002C10", "DDQ002C7", "DDQ002C10", "DDQ002C9", "DDQ002C11", "DDQ002C12", "DDQ002C13", "DDQ002C14", "DDQ002C15", "DDQ002C7", "DDQ002C9" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
The movement of the presequence through the inner membrane requires a membrane potential (14,15), whereas import of the rest of the protein requires translocation channel associated ‘import motor machinery’ (7,9).
[ "6", "10", "6", "8", "10", "7", "10", "9", "11", "12", "13", "14", "15", "7", "9" ]
213
37,341
0
false
The movement of the presequence through the inner membrane requires a membrane potential, whereas import of the rest of the protein requires translocation channel associated ‘import motor machinery’.
[ "14,15", "7,9" ]
The movement of the presequence through the inner membrane requires a membrane potential, whereas import of the rest of the protein requires translocation channel associated ‘import motor machinery’.
true
true
true
true
true
6,402
2
INTRODUCTION
1
8
[ "DDQ002C8", "DDQ002C16", "DDQ002C20", "DDQ002C21", "DDQ002C23", "DDQ002C24", "DDQ002C25", "DDQ002C26", "DDQ002C24", "DDQ002C27" ]
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
The yeast import motor consists of five essential subunits namely, mtHsp70 (Ssc1), Tim44, Pam18, Pam16, Mge1 (8,16–20), and two non-essential subunits, Pam17 and Tam41 (21–23).
[ "8", "16", "20", "21", "23", "24", "25", "26", "24", "27" ]
176
37,342
0
false
The yeast import motor consists of five essential subunits namely, mtHsp70 (Ssc1), Tim44, Pam18, Pam16, Mge1, and two non-essential subunits, Pam17 and Tam41.
[ "8,16–20", "21–23" ]
The yeast import motor consists of five essential subunits namely, mtHsp70 (Ssc1), Tim44, Pam18, Pam16, Mge1, and two non-essential subunits, Pam17 and Tam41.
true
true
true
true
true
6,403
2
INTRODUCTION
1
8
[ "DDQ002C8", "DDQ002C16", "DDQ002C20", "DDQ002C21", "DDQ002C23", "DDQ002C24", "DDQ002C25", "DDQ002C26", "DDQ002C24", "DDQ002C27" ]
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
A critical core component of this machinery is the major mitochondrial 70 kDa heat shock protein (mtHsp70; Ssc1 in yeast), which binds short hydrophobic segments of incoming polypeptide chains (24,25).
[ "8", "16", "20", "21", "23", "24", "25", "26", "24", "27" ]
201
37,343
0
false
A critical core component of this machinery is the major mitochondrial 70 kDa heat shock protein (mtHsp70; Ssc1 in yeast), which binds short hydrophobic segments of incoming polypeptide chains.
[ "24,25" ]
A critical core component of this machinery is the major mitochondrial 70 kDa heat shock protein (mtHsp70; Ssc1 in yeast), which binds short hydrophobic segments of incoming polypeptide chains.
true
true
true
true
true
6,403
2
INTRODUCTION
1
26
[ "DDQ002C8", "DDQ002C16", "DDQ002C20", "DDQ002C21", "DDQ002C23", "DDQ002C24", "DDQ002C25", "DDQ002C26", "DDQ002C24", "DDQ002C27" ]
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
MtHsp70 is tethered to the import channel via its interaction with an essential peripheral membrane component of the channel, Tim44 (26).
[ "8", "16", "20", "21", "23", "24", "25", "26", "24", "27" ]
137
37,344
1
false
MtHsp70 is tethered to the import channel via its interaction with an essential peripheral membrane component of the channel, Tim44.
[ "26" ]
MtHsp70 is tethered to the import channel via its interaction with an essential peripheral membrane component of the channel, Tim44.
true
true
true
true
true
6,403
2
INTRODUCTION
1
8
[ "DDQ002C8", "DDQ002C16", "DDQ002C20", "DDQ002C21", "DDQ002C23", "DDQ002C24", "DDQ002C25", "DDQ002C26", "DDQ002C24", "DDQ002C27" ]
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
This interaction is destabilized upon binding a translocating precursor polypeptide (24,27).
[ "8", "16", "20", "21", "23", "24", "25", "26", "24", "27" ]
92
37,345
0
false
This interaction is destabilized upon binding a translocating precursor polypeptide.
[ "24,27" ]
This interaction is destabilized upon binding a translocating precursor polypeptide.
true
true
true
true
true
6,403
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
Recently, two additional critical components of the import motor, a J-protein (Pam18) (28–30) and J-like protein (Pam16) (16,17,31) have been identified.
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
153
37,346
0
false
Recently, two additional critical components of the import motor, a J-protein (Pam18) and J-like protein have been identified.
[ "28–30", "Pam16", "16,17,31" ]
Recently, two additional critical components of the import motor, a J-protein and J-like protein have been identified.
true
true
true
true
true
6,404
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
Pam18 and Pam16 proteins are highly conserved (16,17).
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
54
37,347
0
false
Pam18 and Pam16 proteins are highly conserved.
[ "16,17" ]
Pam18 and Pam16 proteins are highly conserved.
true
true
true
true
true
6,404
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
As expected of a J-protein, Pam18 stimulates Ssc1's ATPase activity and stabilizes the interaction with precursor proteins, thus carries out an essential function during the translocation process (28–30).
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
204
37,348
0
false
As expected of a J-protein, Pam18 stimulates Ssc1's ATPase activity and stabilizes the interaction with precursor proteins, thus carries out an essential function during the translocation process.
[ "28–30" ]
As expected of a J-protein, Pam18 stimulates Ssc1's ATPase activity and stabilizes the interaction with precursor proteins, thus carries out an essential function during the translocation process.
true
true
true
true
true
6,404
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
Pam16 regulates Pam18's ATPase stimulating activity by forming a functional heterodimer through its C-terminal domain (31–33).
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
126
37,349
0
false
Pam16 regulates Pam18's ATPase stimulating activity by forming a functional heterodimer through its C-terminal domain.
[ "31–33" ]
Pam16 regulates Pam18's ATPase stimulating activity by forming a functional heterodimer through its C-terminal domain.
true
true
true
true
true
6,404
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
A stable heterodimer is required for the protein translocation and viability of yeast cells (31,34,35).
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
103
37,350
0
false
A stable heterodimer is required for the protein translocation and viability of yeast cells.
[ "31,34,35" ]
A stable heterodimer is required for the protein translocation and viability of yeast cells.
true
true
true
true
true
6,404
3
INTRODUCTION
1
36
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
Pam18:Pam16 heterodimer is tethered to the translocon via multiple interactions with other components of the translocation channel and regulates the import motor activity (36).
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
176
37,351
1
false
Pam18:Pam16 heterodimer is tethered to the translocon via multiple interactions with other components of the translocation channel and regulates the import motor activity.
[ "36" ]
Pam18:Pam16 heterodimer is tethered to the translocon via multiple interactions with other components of the translocation channel and regulates the import motor activity.
true
true
true
true
true
6,404
3
INTRODUCTION
1
28
[ "DDQ002C28", "DDQ002C30", "DDQ002C16", "DDQ002C17", "DDQ002C31", "DDQ002C16", "DDQ002C17", "DDQ002C28", "DDQ002C30", "DDQ002C31", "DDQ002C33", "DDQ002C31", "DDQ002C34", "DDQ002C35", "DDQ002C36" ]
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
However, the precise mechanism of regulation of the import motor by Pam16 is not clearly understood.
[ "28", "30", "16", "17", "31", "16", "17", "28", "30", "31", "33", "31", "34", "35", "36" ]
100
37,352
0
false
However, the precise mechanism of regulation of the import motor by Pam16 is not clearly understood.
[]
However, the precise mechanism of regulation of the import motor by Pam16 is not clearly understood.
true
true
true
true
true
6,404
4
INTRODUCTION
1
37
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
The proteins homologous to yeast Pam16 have been reported in other organisms (37).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
82
37,353
1
false
The proteins homologous to yeast Pam16 have been reported in other organisms.
[ "37" ]
The proteins homologous to yeast Pam16 have been reported in other organisms.
true
true
true
true
true
6,405
4
INTRODUCTION
1
38
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
A homologous deletion mutant in Drosophila was found to be lethal at the first instar larval stage (38).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
104
37,354
1
false
A homologous deletion mutant in Drosophila was found to be lethal at the first instar larval stage.
[ "38" ]
A homologous deletion mutant in Drosophila was found to be lethal at the first instar larval stage.
true
true
true
true
true
6,405
4
INTRODUCTION
1
37
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Magmas-like proteins are found essential for the development of murine and Caenorhabditis elegans (39,40).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
106
37,355
0
false
Magmas-like proteins are found essential for the development of murine and Caenorhabditis elegans.
[ "39,40" ]
Magmas-like proteins are found essential for the development of murine and Caenorhabditis elegans.
true
true
true
true
true
6,405
4
INTRODUCTION
1
37
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
In humans, mitochondria-associated granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling molecule (referred as ‘Magmas’, ortholog of yeast Pam16) was first reported as a protein upregulated in PGMD1 cells cultured in a GM-CSF rich medium and not in cells exposed to Interleukin-3.
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
294
37,356
0
false
In humans, mitochondria-associated granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling molecule (referred as ‘Magmas’, ortholog of yeast Pam16) was first reported as a protein upregulated in PGMD1 cells cultured in a GM-CSF rich medium and not in cells exposed to Interleukin-3.
[]
In humans, mitochondria-associated granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling molecule (referred as ‘Magmas’, ortholog of yeast Pam16) was first reported as a protein upregulated in PGMD1 cells cultured in a GM-CSF rich medium and not in cells exposed to Interleukin-3.
true
true
true
true
true
6,405
4
INTRODUCTION
1
41
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Reduced Magmas expression in PGMD1 cells under GM-CSF resulted in decreased proliferative rates in a dose-responsive manner (41).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
129
37,357
1
false
Reduced Magmas expression in PGMD1 cells under GM-CSF resulted in decreased proliferative rates in a dose-responsive manner.
[ "41" ]
Reduced Magmas expression in PGMD1 cells under GM-CSF resulted in decreased proliferative rates in a dose-responsive manner.
true
true
true
true
true
6,405
4
INTRODUCTION
1
40
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
During the developmental stages of animals, expression of Magmas was upregulated in muscle, testis, intestinal mucosa and liver (40).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
133
37,358
1
false
During the developmental stages of animals, expression of Magmas was upregulated in muscle, testis, intestinal mucosa and liver.
[ "40" ]
During the developmental stages of animals, expression of Magmas was upregulated in muscle, testis, intestinal mucosa and liver.
true
true
true
true
true
6,405
4
INTRODUCTION
1
42
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Magmas levels were also found to be upregulated in neoplastic prostate in humans, though its expression is restricted only to a subset of tumors (42).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
150
37,359
1
false
Magmas levels were also found to be upregulated in neoplastic prostate in humans, though its expression is restricted only to a subset of tumors.
[ "42" ]
Magmas levels were also found to be upregulated in neoplastic prostate in humans, though its expression is restricted only to a subset of tumors.
true
true
true
true
true
6,405
4
INTRODUCTION
1
37
[ "DDQ002C37", "DDQ002C38", "DDQ002C39", "DDQ002C40", "DDQ002C41", "DDQ002C40", "DDQ002C42", "DDQ002C41", "DDQ002C43" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
On the basis of these observations, it has been proposed that Magmas functions as a ‘signaling molecule’ and perhaps controls anaerobic metabolism, resistance to apoptosis or altered growth sensitivity in mammalian system (41–43).
[ "37", "38", "39", "40", "41", "40", "42", "41", "43" ]
230
37,360
0
false
On the basis of these observations, it has been proposed that Magmas functions as a ‘signaling molecule’ and perhaps controls anaerobic metabolism, resistance to apoptosis or altered growth sensitivity in mammalian system.
[ "41–43" ]
On the basis of these observations, it has been proposed that Magmas functions as a ‘signaling molecule’ and perhaps controls anaerobic metabolism, resistance to apoptosis or altered growth sensitivity in mammalian system.
true
true
true
true
true
6,405
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Although Magmas levels are upregulated in different developmental stages and various pathophysiological conditions including prostate cancer, little functional information about human Magmas is available.
null
204
37,361
0
false
null
null
Although Magmas levels are upregulated in different developmental stages and various pathophysiological conditions including prostate cancer, little functional information about human Magmas is available.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
On the basis of a weak sequence and predicted structural fold similarity with yPam16's J-like domain, we sought to determine the function of Magmas in humans.
null
158
37,362
0
false
null
null
On the basis of a weak sequence and predicted structural fold similarity with yPam16's J-like domain, we sought to determine the function of Magmas in humans.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
We found that Magmas is an ortholog of yeast Pam16 and has similar functions; and it complements the growth of yeast cells deleted for Pam16.
null
141
37,363
0
false
null
null
We found that Magmas is an ortholog of yeast Pam16 and has similar functions; and it complements the growth of yeast cells deleted for Pam16.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Moreover, Magmas interacts with yeast Pam18 as well as human DnaJC19 (ortholog of yeast Pam18) both in vivo and in vitro conditions to form a heterodimeric subcomplex.
null
167
37,364
0
false
null
null
Moreover, Magmas interacts with yeast Pam18 as well as human DnaJC19 (ortholog of yeast Pam18) both in vivo and in vitro conditions to form a heterodimeric subcomplex.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
The residues critical for the association of Magmas with yPam18, DnaJC19 and translocation channel were identified.
null
115
37,365
0
false
null
null
The residues critical for the association of Magmas with yPam18, DnaJC19 and translocation channel were identified.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Our results are consistent with the existence of stable interaction between Magmas and DnaJC19 that plays a crucial role in tethering of DnaJC19 at the translocon and perhaps regulating human import motor activity.
null
214
37,366
0
false
null
null
Our results are consistent with the existence of stable interaction between Magmas and DnaJC19 that plays a crucial role in tethering of DnaJC19 at the translocon and perhaps regulating human import motor activity.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
We have identified the minimal region of DnaJC19 essential for its association with Magmas.
null
91
37,367
0
false
null
null
We have identified the minimal region of DnaJC19 essential for its association with Magmas.
true
true
true
true
true
6,406
5
INTRODUCTION
0
null
null
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Thus, our study underlines the possible molecular mechanism for the physiological symptoms of dilated cardiomyopathy with ataxia (DCM) syndrome which is associated with a truncated DnaJC19 protein.
null
197
37,368
0
false
null
null
Thus, our study underlines the possible molecular mechanism for the physiological symptoms of dilated cardiomyopathy with ataxia (DCM) syndrome which is associated with a truncated DnaJC19 protein.
true
true
true
true
true
6,406
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Protein transport is a highly regulated process that depends on the critical functioning of inner mitochondrial ‘import motor’ components (8,9).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
144
37,369
0
false
Protein transport is a highly regulated process that depends on the critical functioning of inner mitochondrial ‘import motor’ components.
[ "8,9" ]
Protein transport is a highly regulated process that depends on the critical functioning of inner mitochondrial ‘import motor’ components.
true
true
true
true
true
6,407
0
DISCUSSION
1
46
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
The proteins related to the yeast import motor are conserved in mammalian mitochondria including humans (46).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
109
37,370
1
false
The proteins related to the yeast import motor are conserved in mammalian mitochondria including humans.
[ "46" ]
The proteins related to the yeast import motor are conserved in mammalian mitochondria including humans.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Depending upon the metabolic state of the cell, the expression of human import motor components is highly regulated, thus controlling the import process.
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
153
37,371
0
false
Depending upon the metabolic state of the cell, the expression of human import motor components is highly regulated, thus controlling the import process.
[]
Depending upon the metabolic state of the cell, the expression of human import motor components is highly regulated, thus controlling the import process.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
The mechanism of regulation of the import process in humans is largely unknown; however, altered regulation leads to severe mitochondrial disorders including neuromuscular diseases and malignancy (47–49).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
204
37,372
0
false
The mechanism of regulation of the import process in humans is largely unknown; however, altered regulation leads to severe mitochondrial disorders including neuromuscular diseases and malignancy.
[ "47–49" ]
The mechanism of regulation of the import process in humans is largely unknown; however, altered regulation leads to severe mitochondrial disorders including neuromuscular diseases and malignancy.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Mammalian Magmas proteins are ubiquitously expressed; and in humans, it was identified as GM-CSF specific signaling molecule which gets overexpressed in neoplastic prostate (41,42).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
181
37,373
0
false
Mammalian Magmas proteins are ubiquitously expressed; and in humans, it was identified as GM-CSF specific signaling molecule which gets overexpressed in neoplastic prostate.
[ "41,42" ]
Mammalian Magmas proteins are ubiquitously expressed; and in humans, it was identified as GM-CSF specific signaling molecule which gets overexpressed in neoplastic prostate.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
Although it has been assumed that Magmas proteins are predicted homologs of yeast Pam16 (16,17), the primary function and mechanism of regulation in mammalian system was still elusive.
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
184
37,374
0
false
Although it has been assumed that Magmas proteins are predicted homologs of yeast Pam16, the primary function and mechanism of regulation in mammalian system was still elusive.
[ "16,17" ]
Although it has been assumed that Magmas proteins are predicted homologs of yeast Pam16, the primary function and mechanism of regulation in mammalian system was still elusive.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
The data presented here on human Magmas provides first experimental evidences to show that the mammalian Magmas proteins are orthologs of yeast Pam16 having similar functions and are essential part of mammalian import motor.
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
224
37,375
0
false
The data presented here on human Magmas provides first experimental evidences to show that the mammalian Magmas proteins are orthologs of yeast Pam16 having similar functions and are essential part of mammalian import motor.
[]
The data presented here on human Magmas provides first experimental evidences to show that the mammalian Magmas proteins are orthologs of yeast Pam16 having similar functions and are essential part of mammalian import motor.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
The primary structure of human Magmas is related to yeast Pam16 and share a common domain organization.
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
103
37,376
0
false
The primary structure of human Magmas is related to yeast Pam16 and share a common domain organization.
[]
The primary structure of human Magmas is related to yeast Pam16 and share a common domain organization.
true
true
true
true
true
6,407
0
DISCUSSION
1
8
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
It consists of predicted N-terminal membrane association domain (TM), middle targeting region (T) and C-terminal J-like domain (J).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
131
37,377
0
false
It consists of predicted N-terminal membrane association domain (TM), middle targeting region (T) and C-terminal J-like domain (J).
[]
It consists of predicted N-terminal membrane association domain (TM), middle targeting region (T) and C-terminal J-like domain (J).
true
true
true
true
true
6,407
0
DISCUSSION
1
32
[ "DDQ002C8", "DDQ002C9", "DDQ002C46", "DDQ002C47", "DDQ002C49", "DDQ002C41", "DDQ002C42", "DDQ002C16", "DDQ002C17", "DDQ002C32" ]
20,053,669
pmid-2862839|pmid-11758801|pmid-11331908|pmid-2225059|pmid-18174896|pmid-17263664|pmid-15232570|pmid-10339406|pmid-16055927|pmid-17934217|pmid-11750097|pmid-15704001|pmid-14981507|pmid-14981506|pmid-16977310
However, it lacks C-terminal extension region of Pam16 which is functionally dispensable in yeast (32).
[ "8", "9", "46", "47", "49", "41", "42", "16", "17", "32" ]
103
37,378
1
false
However, it lacks C-terminal extension region of Pam16 which is functionally dispensable in yeast.
[ "32" ]
However, it lacks C-terminal extension region of Pam16 which is functionally dispensable in yeast.
true
true
true
true
true
6,407
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Human Magmas is an ortholog of yeast Pam16 in several aspects and performs the similar function.
[ "16", "17" ]
96
37,379
0
false
Human Magmas is an ortholog of yeast Pam16 in several aspects and performs the similar function.
[]
Human Magmas is an ortholog of yeast Pam16 in several aspects and performs the similar function.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Several biochemical and genetic evidences are presented here to support this idea.
[ "16", "17" ]
82
37,380
0
false
Several biochemical and genetic evidences are presented here to support this idea.
[]
Several biochemical and genetic evidences are presented here to support this idea.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
First, it shows a complete growth support of yeast cells deleted for essential PAM16 gene at all conditions.
[ "16", "17" ]
108
37,381
0
false
First, it shows a complete growth support of yeast cells deleted for essential PAM16 gene at all conditions.
[]
First, it shows a complete growth support of yeast cells deleted for essential PAM16 gene at all conditions.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
These observations highlight a possible similar essential functional role for Magmas in humans.
[ "16", "17" ]
95
37,382
0
false
These observations highlight a possible similar essential functional role for Magmas in humans.
[]
These observations highlight a possible similar essential functional role for Magmas in humans.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Second, it localizes into mitochondria when expressed in Δpam16 cells as well as in human HeLa and HEK293T cells when expressed as GFP fusion proteins.
[ "16", "17" ]
151
37,383
0
false
Second, it localizes into mitochondria when expressed in Δpam16 cells as well as in human HeLa and HEK293T cells when expressed as GFP fusion proteins.
[]
Second, it localizes into mitochondria when expressed in Δpam16 cells as well as in human HeLa and HEK293T cells when expressed as GFP fusion proteins.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
These observations were further supported by enrichment of the protein levels in purified mitochondria from yeast and human cell lines, respectively.
[ "16", "17" ]
149
37,384
0
false
These observations were further supported by enrichment of the protein levels in purified mitochondria from yeast and human cell lines, respectively.
[]
These observations were further supported by enrichment of the protein levels in purified mitochondria from yeast and human cell lines, respectively.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Third, in both yeast and human, Magmas is tightly associated with the inner mitochondrial membrane.
[ "16", "17" ]
99
37,385
0
false
Third, in both yeast and human, Magmas is tightly associated with the inner mitochondrial membrane.
[]
Third, in both yeast and human, Magmas is tightly associated with the inner mitochondrial membrane.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Similar to Pam16, Magmas was fractionated into inner membrane pellet fraction and resistant to high salt extraction.
[ "16", "17" ]
116
37,386
0
false
Similar to Pam16, Magmas was fractionated into inner membrane pellet fraction and resistant to high salt extraction.
[]
Similar to Pam16, Magmas was fractionated into inner membrane pellet fraction and resistant to high salt extraction.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
However, majority of Magmas was extracted from pellet fraction at alkaline pH, indicating that it is a peripherally associated with inner mitochondrial membrane protein.
[ "16", "17" ]
169
37,387
0
false
However, majority of Magmas was extracted from pellet fraction at alkaline pH, indicating that it is a peripherally associated with inner mitochondrial membrane protein.
[]
However, majority of Magmas was extracted from pellet fraction at alkaline pH, indicating that it is a peripherally associated with inner mitochondrial membrane protein.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Fourth, like Pam16, Magmas is associated with mitochondrial TIM23 complex in Δpam16 yeast cells as well as in humans.
[ "16", "17" ]
117
37,388
0
false
Fourth, like Pam16, Magmas is associated with mitochondrial TIM23 complex in Δpam16 yeast cells as well as in humans.
[]
Fourth, like Pam16, Magmas is associated with mitochondrial TIM23 complex in Δpam16 yeast cells as well as in humans.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Fifth, Magmas regulates the ATPase stimulation activity of yPam18 as well as DnaJC19 in humans by forming a stable subcomplex through their C-terminal regions, thus regulating Ssc1 and human mtHsp70 (Mortalin) activity during the import process.
[ "16", "17" ]
245
37,389
0
false
Fifth, Magmas regulates the ATPase stimulation activity of yPam18 as well as DnaJC19 in humans by forming a stable subcomplex through their C-terminal regions, thus regulating Ssc1 and human mtHsp70 (Mortalin) activity during the import process.
[]
Fifth, Magmas regulates the ATPase stimulation activity of yPam18 as well as DnaJC19 in humans by forming a stable subcomplex through their C-terminal regions, thus regulating Ssc1 and human mtHsp70 (Mortalin) activity during the import process.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Sixth, like Pam16, Magmas plays an essential role in import of precursor proteins into the mitochondrial matrix.
[ "16", "17" ]
112
37,390
0
false
Sixth, like Pam16, Magmas plays an essential role in import of precursor proteins into the mitochondrial matrix.
[]
Sixth, like Pam16, Magmas plays an essential role in import of precursor proteins into the mitochondrial matrix.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Previously, it has been shown that downregulation of Pam16 level leads to the accumulation of precursor form of Hsp60 in yeast cells suggesting its essential role in protein import (16,17).
[ "16", "17" ]
189
37,391
0
false
Previously, it has been shown that downregulation of Pam16 level leads to the accumulation of precursor form of Hsp60 in yeast cells suggesting its essential role in protein import.
[ "16,17" ]
Previously, it has been shown that downregulation of Pam16 level leads to the accumulation of precursor form of Hsp60 in yeast cells suggesting its essential role in protein import.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
Similarly, Δpam16 yeast cells expressing wt Magmas did not show the accumulation of precursor form of Hsp60 when exposed to non-permissive temperature, indicating that Magmas can complement the import function of Pam16.
[ "16", "17" ]
219
37,392
0
false
Similarly, Δpam16 yeast cells expressing wt Magmas did not show the accumulation of precursor form of Hsp60 when exposed to non-permissive temperature, indicating that Magmas can complement the import function of Pam16.
[]
Similarly, Δpam16 yeast cells expressing wt Magmas did not show the accumulation of precursor form of Hsp60 when exposed to non-permissive temperature, indicating that Magmas can complement the import function of Pam16.
true
true
true
true
true
6,408
1
DISCUSSION
1
16
[ "DDQ002C16", "DDQ002C17" ]
20,053,669
pmid-17514892|pmid-11450972|pmid-17514892|pmid-17263664|pmid-11450972|pmid-12154367|pmid-11450972|pmid-15232570|pmid-18692467|pmid-12191765|pmid-12437924|pmid-1833391|pmid-8631295|pmid-12154367|pmid-15232570|pmid-14981507|pmid-14981506
In addition to that, Magmas also supported a wild-type level of protein import of model preprotein, Cytb2(47)-DHFR into the Δpam16 mitochondria.
[ "16", "17" ]
144
37,393
0
false
In addition to that, Magmas also supported a wild-type level of protein import of model preprotein, Cytb2(47)-DHFR into the Δpam16 mitochondria.
[]
In addition to that, Magmas also supported a wild-type level of protein import of model preprotein, Cytb2(47)-DHFR into the Δpam16 mitochondria.
true
true
true
true
true
6,408
2
DISCUSSION
0
null
null
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
Our results demonstrate that Magmas protein interacts with yPam18 and DnaJC19 via their J-like and J-domains to form a stable subcomplex.
null
137
37,394
0
false
null
null
Our results demonstrate that Magmas protein interacts with yPam18 and DnaJC19 via their J-like and J-domains to form a stable subcomplex.
true
true
true
true
true
6,409
2
DISCUSSION
0
null
null
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
The J-like and J-domain of Magmas and yPam18/DnaJC19, respectively, are competent to form a subcomplex with similar affinities and a stable Magmas:yPam18 and Magmas:DnaJC19 subcomplex was co-immunoprecipitated in yeast and human mitochondrial lysates.
null
251
37,395
0
false
null
null
The J-like and J-domain of Magmas and yPam18/DnaJC19, respectively, are competent to form a subcomplex with similar affinities and a stable Magmas:yPam18 and Magmas:DnaJC19 subcomplex was co-immunoprecipitated in yeast and human mitochondrial lysates.
true
true
true
true
true
6,409
2
DISCUSSION
0
null
null
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
Formation of a similar subcomplex between Pam16 and Pam18 was reported earlier in yeast.
null
88
37,396
0
false
null
null
Formation of a similar subcomplex between Pam16 and Pam18 was reported earlier in yeast.
true
true
true
true
true
6,409
2
DISCUSSION
0
null
null
20,053,669
pmid-17263664|pmid-14981507|pmid-8246957|pmid-16943180|pmid-16790493|pmid-12677068|pmid-8408191|pmid-11733493|pmid-12677068|pmid-18426906
Hence, our findings clearly broaden the idea of evolutionary conserved existence of such subcomplex from yeast to human systems.
null
128
37,397
0
false
null
null
Hence, our findings clearly broaden the idea of evolutionary conserved existence of such subcomplex from yeast to human systems.
true
true
true
true
true
6,409
3
DISCUSSION
0
null
null
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
A stable interaction between J-like domain of Magmas and J-domain of yPam18/DnaJC19 is required for in vivo function.
null
117
37,398
0
false
null
null
A stable interaction between J-like domain of Magmas and J-domain of yPam18/DnaJC19 is required for in vivo function.
true
true
true
true
true
6,410
3
DISCUSSION
0
null
null
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
A single amino acid alteration in helix I and helix III region of the J-like domain of Magmas compromises growth of yeast cells and is associated with an unstable Magmas/yPam18 subcomplex.
null
188
37,399
0
false
null
null
A single amino acid alteration in helix I and helix III region of the J-like domain of Magmas compromises growth of yeast cells and is associated with an unstable Magmas/yPam18 subcomplex.
true
true
true
true
true
6,410
3
DISCUSSION
0
null
null
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
The mutant proteins also showed a dramatic decrease in affinity for their interaction with yPam18 and human Pam18 ortholog DnaJC19 proteins; envisioning a similar defect in subcomplex formation in human mitochondria.
null
216
37,400
0
false
null
null
The mutant proteins also showed a dramatic decrease in affinity for their interaction with yPam18 and human Pam18 ortholog DnaJC19 proteins; envisioning a similar defect in subcomplex formation in human mitochondria.
true
true
true
true
true
6,410
3
DISCUSSION
0
null
null
20,053,669
pmid-14517234|pmid-14605210|pmid-14981507|pmid-14981506|pmid-16105940|pmid-14981507|pmid-14981506|pmid-14517234|pmid-14605210|pmid-16105940|pmid-19564938|pmid-16105940|pmid-15218029|pmid-17242434|pmid-18003975
The corresponding in vivo and in organellar protein translocation defect associated with the Magmas mutants is consistent with the idea that the protein import and growth defects of cells expressing the mutant proteins are caused by instability of the subcomplex.
null
263
37,401
0
false
null
null
The corresponding in vivo and in organellar protein translocation defect associated with the Magmas mutants is consistent with the idea that the protein import and growth defects of cells expressing the mutant proteins are caused by instability of the subcomplex.
true
true
true
true
true
6,410
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Our findings support the hypothesis of Magmas playing a critical role in positioning of J-protein, Pam18/DnaJC19 to the translocon and perhaps regulating the import motor activity in mammalian system.
[ "36", "36" ]
200
37,402
0
false
Our findings support the hypothesis of Magmas playing a critical role in positioning of J-protein, Pam18/DnaJC19 to the translocon and perhaps regulating the import motor activity in mammalian system.
[]
Our findings support the hypothesis of Magmas playing a critical role in positioning of J-protein, Pam18/DnaJC19 to the translocon and perhaps regulating the import motor activity in mammalian system.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
In yeast, it was demonstrated that Pam16 plays a crucial role in tethering Pam18 to the translocon possibly by interacting through Tim44 with its N-terminal domain (36).
[ "36", "36" ]
169
37,403
1
false
In yeast, it was demonstrated that Pam16 plays a crucial role in tethering Pam18 to the translocon possibly by interacting through Tim44 with its N-terminal domain.
[ "36" ]
In yeast, it was demonstrated that Pam16 plays a crucial role in tethering Pam18 to the translocon possibly by interacting through Tim44 with its N-terminal domain.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Although the Ts mutants of Pam16 showed a compromised heterodimer subcomplex formation, a significantly reduced interaction of Pam18 at the translocon was observed, but Pam16 association remained unaffected (36).
[ "36", "36" ]
212
37,404
1
false
Although the Ts mutants of Pam16 showed a compromised heterodimer subcomplex formation, a significantly reduced interaction of Pam18 at the translocon was observed, but Pam16 association remained unaffected.
[ "36" ]
Although the Ts mutants of Pam16 showed a compromised heterodimer subcomplex formation, a significantly reduced interaction of Pam18 at the translocon was observed, but Pam16 association remained unaffected.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Supporting this data, Magmas Ts mutants also showed a similar reduced co-precipitation of yPam18, but not of Magmas with the translocon when Magmas:yPam18 subcomplex formation was compromised.
[ "36", "36" ]
192
37,405
0
false
Supporting this data, Magmas Ts mutants also showed a similar reduced co-precipitation of yPam18, but not of Magmas with the translocon when Magmas:yPam18 subcomplex formation was compromised.
[]
Supporting this data, Magmas Ts mutants also showed a similar reduced co-precipitation of yPam18, but not of Magmas with the translocon when Magmas:yPam18 subcomplex formation was compromised.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
Owing to compromised heterodimer formation, the Magmas mutants were found to be defective in regulating ATPase activity of human import motor.
[ "36", "36" ]
142
37,406
0
false
Owing to compromised heterodimer formation, the Magmas mutants were found to be defective in regulating ATPase activity of human import motor.
[]
Owing to compromised heterodimer formation, the Magmas mutants were found to be defective in regulating ATPase activity of human import motor.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
This is consistent with an important role for Magmas in tethering yPam18/DnaJC19 to the translocon.
[ "36", "36" ]
99
37,407
0
false
This is consistent with an important role for Magmas in tethering yPam18/DnaJC19 to the translocon.
[]
This is consistent with an important role for Magmas in tethering yPam18/DnaJC19 to the translocon.
true
true
true
true
true
6,411
4
DISCUSSION
1
36
[ "DDQ002C36", "DDQ002C36" ]
20,053,669
pmid-15984936|pmid-11179663|pmid-11099034|pmid-12704206|pmid-11750097|pmid-12704206|pmid-15704001|pmid-11750097|pmid-18451534|pmid-18003975|pmid-18003975
On the basis of our analysis, we conclude that both Magmas and Pam16 share a common function across species and evolved precisely to alter Pam18's level at the translocon by forming subcomplex through their C-terminal regions, thus regulating the mitochondrial activity.
[ "36", "36" ]
270
37,408
0
false
On the basis of our analysis, we conclude that both Magmas and Pam16 share a common function across species and evolved precisely to alter Pam18's level at the translocon by forming subcomplex through their C-terminal regions, thus regulating the mitochondrial activity.
[]
On the basis of our analysis, we conclude that both Magmas and Pam16 share a common function across species and evolved precisely to alter Pam18's level at the translocon by forming subcomplex through their C-terminal regions, thus regulating the mitochondrial activity.
true
true
true
true
true
6,411
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Although we have assigned a primary function for Magmas, understanding the mechanisms of regulation of Magmas as well as DnaJC19 is of utmost importance for the mitochondrial physiology.
[ "41", "42", "47", "47", "47" ]
186
37,409
0
false
Although we have assigned a primary function for Magmas, understanding the mechanisms of regulation of Magmas as well as DnaJC19 is of utmost importance for the mitochondrial physiology.
[]
Although we have assigned a primary function for Magmas, understanding the mechanisms of regulation of Magmas as well as DnaJC19 is of utmost importance for the mitochondrial physiology.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
There are numerous connections between altered Magmas levels and DnaJC19's function with mitochondrial pathophysiology: (i) Magmas levels is highly upregulated in prostate carcinoma and in response to GM-CSF treatment (41,42).
[ "41", "42", "47", "47", "47" ]
226
37,410
0
false
There are numerous connections between altered Magmas levels and DnaJC19's function with mitochondrial pathophysiology: (i) Magmas levels is highly upregulated in prostate carcinoma and in response to GM-CSF treatment.
[ "41,42" ]
There are numerous connections between altered Magmas levels and DnaJC19's function with mitochondrial pathophysiology: (i) Magmas levels is highly upregulated in prostate carcinoma and in response to GM-CSF treatment.
true
true
true
true
true
6,412
5
DISCUSSION
1
47
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
(ii) Truncated DnaJC19 (devoid of its J-domain) protein causes a severe genetic disorder called DCM syndrome characterized by respiratory, cardiac and neurological symptoms (47).
[ "41", "42", "47", "47", "47" ]
178
37,411
1
false
(ii) Truncated DnaJC19 (devoid of its J-domain) protein causes a severe genetic disorder called DCM syndrome characterized by respiratory, cardiac and neurological symptoms.
[ "47" ]
(ii) Truncated DnaJC19 (devoid of its J-domain) protein causes a severe genetic disorder called DCM syndrome characterized by respiratory, cardiac and neurological symptoms.
false
false
true
true
false
6,412
5
DISCUSSION
1
47
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
DCM syndrome is an autosomal recessive disorder prevalent in Canadian and ancestral European population and an IVS3-1G→C mutation was identified upon genotyping the disease haplotypes (47).
[ "41", "42", "47", "47", "47" ]
189
37,412
1
false
DCM syndrome is an autosomal recessive disorder prevalent in Canadian and ancestral European population and an IVS3-1G→C mutation was identified upon genotyping the disease haplotypes.
[ "47" ]
DCM syndrome is an autosomal recessive disorder prevalent in Canadian and ancestral European population and an IVS3-1G→C mutation was identified upon genotyping the disease haplotypes.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
The mutation causes abnormal splicing that result in the truncation of exon 4 followed by a stop codon.
[ "41", "42", "47", "47", "47" ]
103
37,413
0
false
The mutation causes abnormal splicing that result in the truncation of exon 4 followed by a stop codon.
[]
The mutation causes abnormal splicing that result in the truncation of exon 4 followed by a stop codon.
true
true
true
true
true
6,412
5
DISCUSSION
1
47
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
Translation of the Δexon 4 transcript produces a protein having a truncated J-domain (47).
[ "41", "42", "47", "47", "47" ]
90
37,414
1
false
Translation of the Δexon 4 transcript produces a protein having a truncated J-domain.
[ "47" ]
Translation of the Δexon 4 transcript produces a protein having a truncated J-domain.
true
true
true
true
true
6,412
5
DISCUSSION
1
41
[ "DDQ002C41", "DDQ002C42", "DDQ002C47", "DDQ002C47", "DDQ002C47" ]
20,053,669
pmid-11750097|pmid-15704001|pmid-16055927|pmid-16055927|pmid-16055927
On the basis of our studies, we propose the molecular etiology underlying the disorder.
[ "41", "42", "47", "47", "47" ]
87
37,415
0
false
On the basis of our studies, we propose the molecular etiology underlying the disorder.
[]
On the basis of our studies, we propose the molecular etiology underlying the disorder.
true
true
true
true
true
6,412