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pmid
int64
cited_id
string
sentences
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list
sent_len
int64
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int64
sent_has_citation
float64
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bool
cited_sentence
string
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list
cln_sentence
string
is_cap
bool
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bool
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bool
cit_qc
bool
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bool
__index_level_0__
int64
3
DISCUSSION
1
Frankenhaeuser and Hodgkin, 1957
[ "bib8", "bib8", "bib8", "bib11", "bib12" ]
12,743,167
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
However, our findings cannot be explained by the standard surface potential theory (Frankenhaeuser and Hodgkin, 1957), which implies that protons shift the voltage dependence of all gating parameters by the same amount at each [Ca2+]e.
[ "Delisle and Satin (2000)", "Delisle and Satin (2000)", "Delisle and Satin (2000)", "Frankenhaeuser and Hodgkin, 1957", "Hille, 2001" ]
235
40,716
1
false
However, our findings cannot be explained by the standard surface potential theory, which implies that protons shift the voltage dependence of all gating parameters by the same amount at each [Ca2+]e.
[ "Frankenhaeuser and Hodgkin, 1957" ]
However, our findings cannot be explained by the standard surface potential theory, which implies that protons shift the voltage dependence of all gating parameters by the same amount at each e.
true
true
true
true
true
7,020
3
DISCUSSION
1
Hille, 2001
[ "bib8", "bib8", "bib8", "bib11", "bib12" ]
12,743,167
NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA|NA
To explain the different proton-induced shifts in voltage dependence of activation and deactivation by the neutralization of surface charges it has to be assumed that this effect is state dependent, in the way that due to structural rearrangements during gating, the channel structure present different substrates for pr...
[ "Delisle and Satin (2000)", "Delisle and Satin (2000)", "Delisle and Satin (2000)", "Frankenhaeuser and Hodgkin, 1957", "Hille, 2001" ]
432
40,717
1
false
To explain the different proton-induced shifts in voltage dependence of activation and deactivation by the neutralization of surface charges it has to be assumed that this effect is state dependent, in the way that due to structural rearrangements during gating, the channel structure present different substrates for pr...
[ "Hille, 2001" ]
To explain the different proton-induced shifts in voltage dependence of activation and deactivation by the neutralization of surface charges it has to be assumed that this effect is state dependent, in the way that due to structural rearrangements during gating, the channel structure present different substrates for pr...
true
true
true
true
true
7,020
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
The standard surface-potential theory also predicts that the effects of increasing extracellular proton and Ca2+ concentrations on the positive shift of the gating parameters are additive (Kwan and Kass, 1993).
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
210
40,718
1
false
The standard surface-potential theory also predicts that the effects of increasing extracellular proton and Ca2+ concentrations on the positive shift of the gating parameters are additive.
[ "Kwan and Kass, 1993" ]
The standard surface-potential theory also predicts that the effects of increasing extracellular proton and Ca2+ concentrations on the positive shift of the gating parameters are additive.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
Our observation that protons shift the activation curve to more positive potentials in the absence of extracellular Ca2+ (Fig.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
126
40,719
0
false
Our observation that protons shift the activation curve to more positive potentials in the absence of extracellular Ca2+ (Fig.
[]
Our observation that protons shift the activation curve to more positive potentials in the absence of extracellular Ca2+ (Fig.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
4, A and B) is therefore incompatible with neutralization of surface charges being the sole mechanism responsible for the shift of activation kinetics.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
151
40,720
0
false
4, A and B) is therefore incompatible with neutralization of surface charges being the sole mechanism responsible for the shift of activation kinetics.
[]
4, A and B) is therefore incompatible with neutralization of surface charges being the sole mechanism responsible for the shift of activation kinetics.
false
false
true
true
false
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
Delisle and Satin (2000) proposed that the reduced voltage sensitivity of activation is due to a proton-induced slowing of voltage dependent transitions distally to channel opening.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
181
40,721
0
false
Delisle and Satin (2000) proposed that the reduced voltage sensitivity of activation is due to a proton-induced slowing of voltage dependent transitions distally to channel opening.
[]
Delisle and Satin (2000) proposed that the reduced voltage sensitivity of activation is due to a proton-induced slowing of voltage dependent transitions distally to channel opening.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
We have extended this idea to explain our results.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
50
40,722
0
false
We have extended this idea to explain our results.
[]
We have extended this idea to explain our results.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
First, we propose that protons not only decrease the voltage sensitivity of the activation (increase s act) but also shift the voltage of half-maximal activation to more positive potentials independently of the neutralization of surface charges.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
245
40,723
0
false
First, we propose that protons not only decrease the voltage sensitivity of the activation (increase s act) but also shift the voltage of half-maximal activation to more positive potentials independently of the neutralization of surface charges.
[]
First, we propose that protons not only decrease the voltage sensitivity of the activation but also shift the voltage of half-maximal activation to more positive potentials independently of the neutralization of surface charges.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
Second, we postulate that Ca2+ inhibits these effects of protons on activation.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
79
40,724
0
false
Second, we postulate that Ca2+ inhibits these effects of protons on activation.
[]
Second, we postulate that Ca2+ inhibits these effects of protons on activation.
true
true
true
true
true
7,021
4
DISCUSSION
1
Kwan and Kass, 1993
[ "bib16", "bib8", "bib8" ]
12,743,167
NA|NA|NA
On the other hand, in accord with Delisle and Satin (2000), we consider that the transition determining macroscopic deactivation is only modulated by the neutralization of negative surface charges.
[ "Kwan and Kass, 1993", "Delisle and Satin (2000)", "Delisle and Satin (2000)" ]
197
40,725
0
false
On the other hand, in accord with Delisle and Satin (2000), we consider that the transition determining macroscopic deactivation is only modulated by the neutralization of negative surface charges.
[]
On the other hand, in accord with Delisle and Satin (2000), we consider that the transition determining macroscopic deactivation is only modulated by the neutralization of negative surface charges.
true
true
true
true
true
7,021
5
DISCUSSION
1
Talavera et al., 2001
[ "bib30", "bib31" ]
12,743,167
NA|NA
We have reported previously that aspartate-to-glutamate mutations in the EEED pore locus of α1G induces changes in the activation curve of the channel (Talavera et al., 2001).
[ "Talavera et al., 2001", "Talavera et al., 2003" ]
175
40,726
1
false
We have reported previously that aspartate-to-glutamate mutations in the EEED pore locus of α1G induces changes in the activation curve of the channel.
[ "Talavera et al., 2001" ]
We have reported previously that aspartate-to-glutamate mutations in the EEED pore locus of α1G induces changes in the activation curve of the channel.
true
true
true
true
true
7,022
5
DISCUSSION
1
Talavera et al., 2001
[ "bib30", "bib31" ]
12,743,167
NA|NA
The present result demonstrate that the EEED mutant shows alterations in the deactivation process, with less negative Vτdeac values and smaller voltage sensitivity for τdeac than the wild-type channel.
[ "Talavera et al., 2001", "Talavera et al., 2003" ]
201
40,727
0
false
The present result demonstrate that the EEED mutant shows alterations in the deactivation process, with less negative Vτdeac values and smaller voltage sensitivity for τdeac than the wild-type channel.
[]
The present result demonstrate that the EEED mutant shows alterations in the deactivation process, with less negative Vτdeac values and smaller voltage sensitivity for τdeac than the wild-type channel.
true
true
true
true
true
7,022
5
DISCUSSION
1
Talavera et al., 2001
[ "bib30", "bib31" ]
12,743,167
NA|NA
These and other gating modifications induced by pore mutations are discussed in the accompanying paper (Talavera et al., 2003, in this issue).
[ "Talavera et al., 2001", "Talavera et al., 2003" ]
142
40,728
0
false
These and other gating modifications induced by pore mutations are discussed in the accompanying paper.
[ "Talavera et al., 2003, in this issue" ]
These and other gating modifications induced by pore mutations are discussed in the accompanying paper.
true
true
true
true
true
7,022
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
The voltage dependence of the inactivation of T-type Ca2+ channels arises from voltage-dependent transitions occurring during channel activation (Droogmans and Nilius, 1989; Chen and Hess, 1990; Serrano et al., 1999; Burgess et al., 2002).
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
239
40,729
0
false
The voltage dependence of the inactivation of T-type Ca2+ channels arises from voltage-dependent transitions occurring during channel activation.
[ "Droogmans and Nilius, 1989; Chen and Hess, 1990; Serrano et al., 1999; Burgess et al., 2002" ]
The voltage dependence of the inactivation of T-type Ca2+ channels arises from voltage-dependent transitions occurring during channel activation.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
Since protons modify the activation process it is interesting to study the possible correlation between the proton-induced changes in the parameters describing steady-state activation and inactivation.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
201
40,730
0
false
Since protons modify the activation process it is interesting to study the possible correlation between the proton-induced changes in the parameters describing steady-state activation and inactivation.
[]
Since protons modify the activation process it is interesting to study the possible correlation between the proton-induced changes in the parameters describing steady-state activation and inactivation.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
We have found that if pHe is changed in the range of 9.1 to 6.2, for each 1 mV shift in V act there was a 0.4–0.5 mV shift in V inac in both 2 and 20 mM Ca2+.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
158
40,731
0
false
We have found that if pHe is changed in the range of 9.1 to 6.2, for each 1 mV shift in V act there was a 0.4–0.5 mV shift in V inac in both 2 and 20 mM Ca2+.
[]
We have found that if pHe is changed in the range of 9.1 to 6.2, for each 1 mV shift in V act there was a 0.4–0.5 mV shift in V inac in both 2 and 20 mM Ca2+.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
A similar correlation factor was calculated from the data of Delisle and Satin (2000) for α1H (their Figs.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
106
40,732
0
false
A similar correlation factor was calculated from the data of Delisle and Satin (2000) for α1H (their Figs.
[]
A similar correlation factor was calculated from the data of Delisle and Satin (2000) for α1H (their Figs.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
1 D and 2 C).
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
13
40,733
0
false
1 D and 2 C).
[]
1 D and 2 C).
false
false
true
true
false
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
On the other hand, there was no strict correlation between the voltage sensitivity of inactivation (s inac) and activation (s act) and between s inac and V inac, in contrast with that observed between s act and V act (see Fig.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
226
40,734
0
false
On the other hand, there was no strict correlation between the voltage sensitivity of inactivation (s inac) and activation (s act) and between s inac and V inac, in contrast with that observed between s act and V act (see Fig.
[]
On the other hand, there was no strict correlation between the voltage sensitivity of inactivation and activation and between s inac and V inac, in contrast with that observed between s act and V act (see Fig.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
Thus, although proton-induced changes in the inactivation and activation processes seem to be linked, their degree of correlation is not absolute.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
146
40,735
0
false
Thus, although proton-induced changes in the inactivation and activation processes seem to be linked, their degree of correlation is not absolute.
[]
Thus, although proton-induced changes in the inactivation and activation processes seem to be linked, their degree of correlation is not absolute.
true
true
true
true
true
7,023
6
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2", "bib8" ]
12,743,167
NA|NA|NA|NA|NA
As we discuss below, a kinetic model that includes state-dependent proton effects can explain these results.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002", "Delisle and Satin (2000)" ]
108
40,736
0
false
As we discuss below, a kinetic model that includes state-dependent proton effects can explain these results.
[]
As we discuss below, a kinetic model that includes state-dependent proton effects can explain these results.
true
true
true
true
true
7,023
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
Currently, there are several kinetic models of T-type channel gating (Droogmans and Nilius, 1989; Chen and Hess, 1990; Serrano et al., 1999; Burgess et al., 2002).
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
163
40,737
0
false
Currently, there are several kinetic models of T-type channel gating.
[ "Droogmans and Nilius, 1989; Chen and Hess, 1990; Serrano et al., 1999; Burgess et al., 2002" ]
Currently, there are several kinetic models of T-type channel gating.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
The model of Burgess et al.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
27
40,738
0
false
The model of Burgess et al.
[]
The model of Burgess et al.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
13) is particularly attractive since it accounts for the properties of the α1G and α1H channels in nearly physiological conditions and includes for the first time an explicit description of the gating charges associated with channel transitions.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
245
40,739
0
false
13) is particularly attractive since it accounts for the properties of the α1G and α1H channels in nearly physiological conditions and includes for the first time an explicit description of the gating charges associated with channel transitions.
[]
13) is particularly attractive since it accounts for the properties of the α1G and α1H channels in nearly physiological conditions and includes for the first time an explicit description of the gating charges associated with channel transitions.
false
false
true
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
We adopted this model and determined which parameters had to be modified in order to describe our experimental data in the different pHe in the presence of 2 or 20 mM Ca2+.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
172
40,740
0
false
We adopted this model and determined which parameters had to be modified in order to describe our experimental data in the different pHe in the presence of 2 or 20 mM Ca2+.
[]
We adopted this model and determined which parameters had to be modified in order to describe our experimental data in the different pHe in the presence of 2 or 20 mM Ca2+.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
First, we readjusted the parameters of the original model to describe our own experimental data at pHe 7.4 in 2 mM Ca2+
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
119
40,741
0
false
First, we readjusted the parameters of the original model to describe our own experimental data at pHe 7.4 in 2 mM Ca2+
[]
First, we readjusted the parameters of the original model to describe our own experimental data at pHe 7.4 in 2 mM Ca2+
true
true
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
(see Table I) .
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
15
40,742
0
false
(see Table I).
[]
.
false
false
true
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
We then considered as working hypothesis that the modifications of gating induced by H+ and Ca2+ are due to: (a) the neutralization of surface charges, (b) state-dependent alterations of the electric field sensed by the gating charges, and (c) the modification of the gating charges.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
283
40,743
0
false
We then considered as working hypothesis that the modifications of gating induced by H+ and Ca2+ are due to: (a) the neutralization of surface charges, (b) state-dependent alterations of the electric field sensed by the gating charges, and (c) the modification of the gating charges.
[]
We then considered as working hypothesis that the modifications of gating induced by H+ and Ca2+ are due to: the neutralization of surface charges, (b) state-dependent alterations of the electric field sensed by the gating charges, and (c) the modification of the gating charges.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
To evaluate these effects independently from each other we used the following approach.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
87
40,744
0
false
To evaluate these effects independently from each other we used the following approach.
[]
To evaluate these effects independently from each other we used the following approach.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
All voltage-dependent transitions, with the exception of the deactivation transitions (O → C3 and IO → I3), were rewritten as: \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Eule...
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
519
40,745
0
false
All voltage-dependent transitions, with the exception of the deactivation transitions (O → C3 and IO → I3), were rewritten as: \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{...
[]
All voltage-dependent transitions, with the exception of the deactivation transitions, were rewritten as: \documentclass{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage{upgreek} \pagestyle{empty} \oddsid...
true
true
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right {\mathrm{;}} \\ \\ k_{C2C1}=K_{C2C1}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{1}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
125
40,746
0
false
\right {\mathrm{;}} \\ \\ k_{C2C1}=K_{C2C1}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{1}\right)
[]
\right {\mathrm{;}} \\ \\ k_{C2C1}=K_{C2C1}{\mathrm{exp}} \left \left[-\frac{ \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right q_{1}}{T} \left \left(V-V_{Shift}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
47
40,747
0
false
\right q_{1}}{T} \left \left(V-V_{Shift}\right)
[]
\right q_{1}}{T} \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather...
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
435
40,748
0
false
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{...
[]
\right] \right \end{gather*}\end{document} \documentclass{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{I1I2}=K_{I1I2...
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right {\mathrm{;}} \\ \;k_{I2I1}=K_{I2I1}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{1}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
122
40,749
0
false
\right {\mathrm{;}} \\ \;k_{I2I1}=K_{I2I1}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{1}\right)
[]
\right {\mathrm{;}} \\ \;k_{I2I1}=K_{I2I1}{\mathrm{exp}} \left \left[-\frac{ \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather...
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
442
40,751
0
false
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{...
[]
\right] \right \end{gather*}\end{document} \documentclass{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{C2C3}=K_{C2C3...
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right {\mathrm{;}} \\ \;k_{C3C2}=K_{C3C2}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{2}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
122
40,752
0
false
\right {\mathrm{;}} \\ \;k_{C3C2}=K_{C3C2}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{2}\right)
[]
\right {\mathrm{;}} \\ \;k_{C3C2}=K_{C3C2}{\mathrm{exp}} \left \left[-\frac{ \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right q_{2}}{T} \left \left(V-V_{Shift}-V_{O2}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
54
40,753
0
false
\right q_{2}}{T} \left \left(V-V_{Shift}-V_{O2}\right)
[]
\right q_{2}}{T} \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather...
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
442
40,754
0
false
\right] \right \end{gather*}\end{document} \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{...
[]
\right] \right \end{gather*}\end{document} \documentclass{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{gather*}k_{I2I3}=K_{I2I3...
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right {\mathrm{;}} \\ \;k_{I3I2}=K_{I3I2}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{2}\right)
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
122
40,755
0
false
\right {\mathrm{;}} \\ \;k_{I3I2}=K_{I3I2}{\mathrm{exp}} \left \left[-\frac{ \left \left(1-{\mathrm{{\delta}}}_{2}\right)
[]
\right {\mathrm{;}} \\ \;k_{I3I2}=K_{I3I2}{\mathrm{exp}} \left \left[-\frac{ \left \left
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
\right {\mathrm{,}}\end{gather*}\end{document}where T = 25.4 mV is the thermal energy in electron-volts, q 1 and q 2 are the gating charges associated with the first and second boxes of the kinetic scheme, and δ1 and δ2 account for the coupling between the local electric potential sensed by q 1 and q 2 and the membrane...
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
330
40,757
0
false
\right {\mathrm{,}}\end{gather*}\end{document}where T = 25.4 mV is the thermal energy in electron-volts, q 1 and q 2 are the gating charges associated with the first and second boxes of the kinetic scheme, and δ1 and δ2 account for the coupling between the local electric potential sensed by q 1 and q 2 and the membrane...
[]
\right {\mathrm{,}}\end{gather*}\end{document}where T = 25.4 mV is the thermal energy in electron-volts, q 1 and q 2 are the gating charges associated with the first and second boxes of the kinetic scheme, and δ1 and δ2 account for the coupling between the local electric potential sensed by q 1 and q 2 and the membrane...
false
false
false
true
false
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
V. We introduced a voltage offset (V Shift) in all these rate constants to describe the neutralization of surface charges.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
122
40,758
0
false
V. We introduced a voltage offset (V Shift) in all these rate constants to describe the neutralization of surface charges.
[]
V. We introduced a voltage offset in all these rate constants to describe the neutralization of surface charges.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
To account for the state-dependent modification of the electric field sensed by the gating charges, we included the voltage offset V O2 in the second box of the kinetic scheme (see Fig.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
185
40,759
0
false
To account for the state-dependent modification of the electric field sensed by the gating charges, we included the voltage offset V O2 in the second box of the kinetic scheme (see Fig.
[]
To account for the state-dependent modification of the electric field sensed by the gating charges, we included the voltage offset V O2 in the second box of the kinetic scheme (see Fig.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
Starting from the set of parameters obtained at pHe 7.4 and 2 mM Ca2+ (Table I), we adapted the parameters V Shift, V O2, q 1, q 2, and k C3O to fit the average activation, steady-state inactivation, reactivation curves and the voltage dependence of the time-to-peak obtained in each experimental condition.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
307
40,760
0
false
Starting from the set of parameters obtained at pHe 7.4 and 2 mM Ca2+ (Table I), we adapted the parameters V Shift, V O2, q 1, q 2, and k C3O to fit the average activation, steady-state inactivation, reactivation curves and the voltage dependence of the time-to-peak obtained in each experimental condition.
[]
Starting from the set of parameters obtained at pHe 7.4 and 2 mM Ca2+, we adapted the parameters V Shift, V O2, q 1, q 2, and k C3O to fit the average activation, steady-state inactivation, reactivation curves and the voltage dependence of the time-to-peak obtained in each experimental condition.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
The variation of δ1 and δ2 did not significantly affect the goodness of the fits and thus they were kept fixed to the values obtained in the reference condition.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
161
40,761
0
false
The variation of δ1 and δ2 did not significantly affect the goodness of the fits and thus they were kept fixed to the values obtained in the reference condition.
[]
The variation of δ1 and δ2 did not significantly affect the goodness of the fits and thus they were kept fixed to the values obtained in the reference condition.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
We introduced an extra voltage offset in order to account for the neutralization of surface charges by Ca2+ to fit the data obtained in 20 mM Ca2+.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
147
40,762
0
false
We introduced an extra voltage offset in order to account for the neutralization of surface charges by Ca2+ to fit the data obtained in 20 mM Ca2+.
[]
We introduced an extra voltage offset in order to account for the neutralization of surface charges by Ca2+ to fit the data obtained in 20 mM Ca2+.
true
true
true
true
true
7,024
7
DISCUSSION
1
Droogmans and Nilius, 1989
[ "bib9", "bib5", "bib24", "bib2" ]
12,743,167
NA|NA|NA|NA
This value was set to 20.5 mV and taken from the shift of the voltage of half-maximal activation by changing the [Ca2+]e from 2 to 20 mM at pHe 9.1 (see Fig.
[ "Droogmans and Nilius, 1989", "Chen and Hess, 1990", "Serrano et al., 1999", "Burgess et al., 2002" ]
157
40,763
0
false
This value was set to 20.5 mV and taken from the shift of the voltage of half-maximal activation by changing the [Ca2+]e from 2 to 20 mM at pHe 9.1 (see Fig.
[]
This value was set to 20.5 mV and taken from the shift of the voltage of half-maximal activation by changing the e from 2 to 20 mM at pHe 9.1 (see Fig.
true
true
true
true
true
7,024
8
DISCUSSION
0
null
null
12,743,167
null
Kinetic scheme of the Markov model used to describe the proton and Ca2+ modulation of the gating of α1G.
null
104
40,764
0
false
null
null
Kinetic scheme of the Markov model used to describe the proton and Ca2+ modulation of the gating of α1G.
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
The states C1 (resting) and I1 (inactivated) are the most probable at very negative potentials (less than or equal to −100 mV).
null
127
40,765
0
false
null
null
The states C1 (resting) and I1 (inactivated) are the most probable at very negative potentials (less than or equal to −100 mV).
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
Membrane depolarization induces transitions to the intermediate closed states C2 and C3 and to the open state O.
null
112
40,766
0
false
null
null
Membrane depolarization induces transitions to the intermediate closed states C2 and C3 and to the open state O.
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
In parallel, the channel transits to the inactivated states I2, I3 and for strong depolarizations the equilibrium shifts to the inactivated state IO.
null
149
40,767
0
false
null
null
In parallel, the channel transits to the inactivated states I2, I3 and for strong depolarizations the equilibrium shifts to the inactivated state IO.
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
All voltage dependent transitions (represented by the thick arrows) are affected by the neutralization of negative surface charges by protons or Ca2+.
null
150
40,768
0
false
null
null
All voltage dependent transitions (represented by the thick arrows) are affected by the neutralization of negative surface charges by protons or Ca2+.
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
The fit of the model to the data obtained at different pHe indicate that the transitions C3 → C2 and I3 → I2 (dashed arrows) are the main target for proton effects leading to the decrease of the voltage sensitivity of activation.
null
229
40,769
0
false
null
null
The fit of the model to the data obtained at different pHe indicate that the transitions C3 → C2 and I3 → I2 (dashed arrows) are the main target for proton effects leading to the decrease of the voltage sensitivity of activation.
true
true
true
true
true
7,025
8
DISCUSSION
0
null
null
12,743,167
null
Extracellular Ca2+ is proposed to inhibit the effects of protons on these transitions.
null
86
40,770
0
false
null
null
Extracellular Ca2+ is proposed to inhibit the effects of protons on these transitions.
true
true
true
true
true
7,025
9
DISCUSSION
0
null
null
12,743,167
null
Model Parameters Optimized to Fit the Experimental Data Obtained at pHe 7.4 in the Presence of 2 mM Extracellular Ca2+
null
118
40,771
0
false
null
null
Model Parameters Optimized to Fit the Experimental Data Obtained at pHe 7.4 in the Presence of 2 mM Extracellular Ca2+
true
true
false
true
false
7,026
10
DISCUSSION
0
null
null
12,743,167
null
The deactivation transitions O → C3 and IO → I3 were described by an equation of the form: \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \odds...
null
465
40,772
0
false
null
null
The deactivation transitions O → C3 and IO → I3 were described by an equation of the form: \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \odds...
true
true
false
true
false
7,027
10
DISCUSSION
0
null
null
12,743,167
null
\right }/{s{\mathrm{{\tau}}}_{deac}}\right]
null
43
40,773
0
false
null
null
\right }/{s{\mathrm{{\tau}}}_{deac}}\right]
false
false
false
true
false
7,027
10
DISCUSSION
0
null
null
12,743,167
null
\right \end{equation*}\end{document}, where Vτdeac (= T/q3 ln(KOC3)) and sτdeac (= T/q3) are the experimental values at each pHe and
null
132
40,774
0
false
null
null
\right \end{equation*}\end{document}, where Vτdeac (= T/q3 ln(KOC3)) and sτdeac (= T/q3) are the experimental values at each pHe and
false
false
false
true
false
7,027
10
DISCUSSION
0
null
null
12,743,167
null
[Ca2+]e (e.g., Fig.
null
19
40,775
0
false
null
null
[Ca2+]e (e.g., Fig.
false
false
true
true
false
7,027
10
DISCUSSION
0
null
null
12,743,167
null
The parameter V Shift is not included in the expressions of k OC3 and k IOI3 because the effect of neutralization of surface charges is implicitly considered in the values of Vτdeac.
null
182
40,776
0
false
null
null
The parameter V Shift is not included in the expressions of k OC3 and k IOI3 because the effect of neutralization of surface charges is implicitly considered in the values of Vτdeac.
true
true
true
true
true
7,027
11
DISCUSSION
0
null
null
12,743,167
null
14 shows that the simulated curves of steady-state activation and inactivation reproduce the experimental data in the pHe range of 9.1 to 6.2–5.5 and in the presence of 2 or 20 mM Ca2+.
null
185
40,777
0
false
null
null
14 shows that the simulated curves of steady-state activation and inactivation reproduce the experimental data in the pHe range of 9.1 to 6.2–5.5 and in the presence of 2 or 20 mM Ca2+.
false
false
true
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The parameters optimized with the fitting procedure are shown as functions of pHe and Ca2+ in Fig.
null
98
40,778
0
false
null
null
The parameters optimized with the fitting procedure are shown as functions of pHe and Ca2+ in Fig.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
V Shift, which describes the proton-induced voltage shift due to the neutralization of surface charges, is equal to −5.5 mV
null
123
40,779
0
false
null
null
V Shift, which describes the proton-induced voltage shift due to the neutralization of surface charges, is equal to −5.5 mV
true
true
false
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
at pHe 9.1 and gradually changes to positive values at acid pHe in 2 mM Ca2+ (panel A).
null
87
40,780
0
false
null
null
at pHe 9.1 and gradually changes to positive values at acid pHe in 2 mM Ca2+ (panel A).
false
true
true
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
Panel B exemplifies that this causes an identical displacement of all the gating kinetics to less negative potentials.
null
118
40,781
0
false
null
null
Panel B exemplifies that this causes an identical displacement of all the gating kinetics to less negative potentials.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
15 C shows that V O2 is around −4 mV at alkaline pHe but changes to positive values at acid pHe in 2 mM Ca2+.
null
109
40,782
0
false
null
null
15 C shows that V O2 is around −4 mV at alkaline pHe but changes to positive values at acid pHe in 2 mM Ca2+.
false
false
true
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
This induces an additional positive shift of the inactivation and activation curves and a slight increase in the steepness of the latter one (panel B).
null
151
40,783
0
false
null
null
This induces an additional positive shift of the inactivation and activation curves and a slight increase in the steepness of the latter one (panel B).
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The relevance of the introduction of V O2 in the model becomes clear when noticing that the voltage shift attributable to the screening of surface charges when changing the pHe from 9.1 to 6.2 (V Shift(6.2)
null
206
40,784
0
false
null
null
The relevance of the introduction of V O2 in the model becomes clear when noticing that the voltage shift attributable to the screening of surface charges when changing the pHe from 9.1 to 6.2 (V Shift(6.2)
true
true
false
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
− V Shift(9.1)
null
14
40,785
0
false
null
null
− V Shift(9.1)
false
false
false
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
≈ 19 mV, Fig.
null
13
40,786
0
false
null
null
≈ 19 mV, Fig.
false
false
true
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
15 A) equals the shift observed in the voltage dependence of the time constant of deactivation (Fig.
null
100
40,787
0
false
null
null
15 A) equals the shift observed in the voltage dependence of the time constant of deactivation (Fig.
false
false
true
true
false
7,028
11
DISCUSSION
0
null
null
12,743,167
null
In other words, V O2 allows dissecting the effect of pure screening of surface charges from specific proton effects on channel activation.
null
138
40,788
0
false
null
null
In other words, V O2 allows dissecting the effect of pure screening of surface charges from specific proton effects on channel activation.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The specificity of this voltage offset on the transitions between the states C2 and C3 may be due to an enhanced accessibility or/and an increased affinity of superficial binding sites for protons during these transitions.
null
222
40,789
0
false
null
null
The specificity of this voltage offset on the transitions between the states C2 and C3 may be due to an enhanced accessibility or/and an increased affinity of superficial binding sites for protons during these transitions.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
Another possibility is that protonation induces an uncoupling between the voltage sensors and the activation gates of the channel.
null
130
40,790
0
false
null
null
Another possibility is that protonation induces an uncoupling between the voltage sensors and the activation gates of the channel.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The appropriate fit of the data requires the reduction of the gating charge.
null
76
40,791
0
false
null
null
The appropriate fit of the data requires the reduction of the gating charge.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
However, the gating charge associated with the second step of activation (q 2) shows a much stronger pHe dependence than that associated with the first step (q 1).
null
163
40,792
0
false
null
null
However, the gating charge associated with the second step of activation (q 2) shows a much stronger pHe dependence than that associated with the first step (q 1).
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
In 2 mM Ca2+ for example, q 2 shows a marked reduction in the whole pHe range studied, whereas q 1 does not change in the pHe range from 9.1 to 6.8 (Fig.
null
153
40,793
0
false
null
null
In 2 mM Ca2+ for example, q 2 shows a marked reduction in the whole pHe range studied, whereas q 1 does not change in the pHe range from 9.1 to 6.8 (Fig.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
As shown in panel D, the predicted decrease in q 1 does not have large effect on the steady-state properties in contrast to the reduction of q 2, which induces a decrease in the slope of activation and inactivation curves (panel F).
null
232
40,794
0
false
null
null
As shown in panel D, the predicted decrease in q 1 does not have large effect on the steady-state properties in contrast to the reduction of q 2, which induces a decrease in the slope of activation and inactivation curves (panel F).
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The decrease in q 2 shifts the inactivation curve to more negative potentials in a larger extent than the activation curve.
null
123
40,795
0
false
null
null
The decrease in q 2 shifts the inactivation curve to more negative potentials in a larger extent than the activation curve.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
This is, therefore, based on the application of the present gating model, the reason for the uneven effects of extracellular protons on activation and inactivation properties of α1G (Fig.
null
187
40,796
0
false
null
null
This is, therefore, based on the application of the present gating model, the reason for the uneven effects of extracellular protons on activation and inactivation properties of α1G (Fig.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
The fit of the voltage dependence of the time-to-peak compelled a decrease of the rate of the last step of the activation (k C3O and k I3O) in the ranges from 4.6 to 1.9 ms−1 in 2 mM Ca2+ and from 2.4 to 1.2 ms−1 in 20 mM Ca2+.
null
227
40,797
0
false
null
null
The fit of the voltage dependence of the time-to-peak compelled a decrease of the rate of the last step of the activation (k C3O and k I3O) in the ranges from 4.6 to 1.9 ms−1 in 2 mM Ca2+ and from 2.4 to 1.2 ms−1 in 20 mM Ca2+.
true
true
true
true
true
7,028
11
DISCUSSION
0
null
null
12,743,167
null
This produces a positive shift of the activation and inactivation curves and an increase of the steepness of the activation curve (compare dotted and short dashed lines in Fig.
null
176
40,798
0
false
null
null
This produces a positive shift of the activation and inactivation curves and an increase of the steepness of the activation curve (compare dotted and short dashed lines in Fig.
true
true
true
true
true
7,028
12
DISCUSSION
0
null
null
12,743,167
null
Fit of the kinetic model to the experimental data.
null
50
40,799
0
false
null
null
Fit of the kinetic model to the experimental data.
true
true
true
true
true
7,029
12
DISCUSSION
0
null
null
12,743,167
null
Fit of average activation (A and C) and inactivation (B and D) curves obtained in the presence of 2 or 20 mM Ca2+.
null
114
40,800
0
false
null
null
Fit of average activation (A and C) and inactivation (B and D) curves obtained in the presence of 2 or 20 mM Ca2+.
true
true
true
true
true
7,029
12
DISCUSSION
0
null
null
12,743,167
null
The symbols apply to pHe values as follows: 9.1, ▪; 8.2, □; 7.4, ○; 6.8, ▵; 6.2, ▿; 5.5, ⋄.
null
91
40,801
0
false
null
null
The symbols apply to pHe values as follows: 9.1, ▪; 8.2, □; 7.4, ○; 6.8, ▵; 6.2, ▿; 5.5, ⋄.
true
true
true
true
true
7,029
13
DISCUSSION
0
null
null
12,743,167
null
pHe and Ca2+ dependence of the model parameters optimized to fit the experimental data.
null
87
40,802
0
false
null
null
pHe and Ca2+ dependence of the model parameters optimized to fit the experimental data.
false
true
true
true
false
7,030
13
DISCUSSION
0
null
null
12,743,167
null
(A) Predicted pHe dependency of V Shift in the presence of 2 (▪) or 20 mM (□) Ca2+.
null
83
40,803
0
false
null
null
(A) Predicted pHe dependency of V Shift in the presence of 2 (▪) or 20 mM (□) Ca2+.
false
false
true
true
false
7,030
13
DISCUSSION
0
null
null
12,743,167
null
(B) Activation and inactivation curves calculated with the parameters from the fit of the data obtained in 2 mM Ca2+ at pHe 9.1 (thick continuous lines) or 6.2 (dotted lines).
null
175
40,804
0
false
null
null
(B) Activation and inactivation curves calculated with the parameters from the fit of the data obtained in 2 mM Ca2+ at pHe 9.1 (thick continuous lines) or 6.2 (dotted lines).
false
false
true
true
false
7,030
13
DISCUSSION
0
null
null
12,743,167
null
The thick dashed and the thin continuous lines are the activation and inactivation curves calculated with the set of parameters determined for pHe 9.1 (Ca2+ 2 mM) but with the values of V Shift or with both V Shift and V O2 obtained for pHe 6.2, respectively.
null
259
40,805
0
false
null
null
The thick dashed and the thin continuous lines are the activation and inactivation curves calculated with the set of parameters determined for pHe 9.1 (Ca2+ 2 mM) but with the values of V Shift or with both V Shift and V O2 obtained for pHe 6.2, respectively.
true
true
true
true
true
7,030
13
DISCUSSION
0
null
null
12,743,167
null
(C) V O2 as function of pHe in the presence of 2 (•) or 20 mM (○) Ca2+.
null
71
40,806
0
false
null
null
(C) V O2 as function of pHe in the presence of 2 (•) or 20 mM (○) Ca2+.
false
false
true
true
false
7,030
13
DISCUSSION
0
null
null
12,743,167
null
The thick continuous, thin continuous, and dotted lines are the same as in B.
null
77
40,807
0
false
null
null
The thick continuous, thin continuous, and dotted lines are the same as in B.
true
true
true
true
true
7,030
13
DISCUSSION
0
null
null
12,743,167
null
The thin dashed lines were calculated using the set of parameters at pHe 9.1 (Ca2+ 2 mM), but using the values of V Shift, V O2, and q 1 determined for pHe 6.2.
null
160
40,808
0
false
null
null
The thin dashed lines were calculated using the set of parameters at pHe 9.1 (Ca2+ 2 mM), but using the values of V Shift, V O2, and q 1 determined for pHe 6.2.
true
true
true
true
true
7,030
13
DISCUSSION
0
null
null
12,743,167
null
(E) Predicted pHe dependency of q 1 (▪, □) and q 2 (•, ○) in the presence of 2 (filled symbols) or 20 mM (empty symbols) Ca2+.
null
126
40,809
0
false
null
null
(E) Predicted pHe dependency of q 1 (▪, □) and q 2 (•, ○) in the presence of 2 (filled symbols) or 20 mM (empty symbols) Ca2+.
false
false
true
true
false
7,030
13
DISCUSSION
0
null
null
12,743,167
null
The thick continuous, thin dashed and dotted lines are the same as in D.
null
72
40,810
0
false
null
null
The thick continuous, thin dashed and dotted lines are the same as in D.
true
true
true
true
true
7,030
13
DISCUSSION
0
null
null
12,743,167
null
The short dashed lines were calculated using the set of parameters at pHe 9.1 (Ca2+ 2 mM) but using the values of V Shift, V O2, q 1, and q 2 determined for pHe 6.2.
null
165
40,811
0
false
null
null
The short dashed lines were calculated using the set of parameters at pHe 9.1 (Ca2+ 2 mM) but using the values of V Shift, V O2, q 1, and q 2 determined for pHe 6.2.
true
true
true
true
true
7,030
14
DISCUSSION
0
null
null
12,743,167
null
The results of the simulation of the data obtained in 20 mM Ca2+ indicate that predicted effects of protons in this condition are much weaker than in 2 mM Ca2+.
null
160
40,812
0
false
null
null
The results of the simulation of the data obtained in 20 mM Ca2+ indicate that predicted effects of protons in this condition are much weaker than in 2 mM Ca2+.
true
true
true
true
true
7,031
14
DISCUSSION
0
null
null
12,743,167
null
We conclude that calcium ions antagonize the effects of extracellular protons on the gating properties of α1G in two ways: first, by competing for the binding to negative surface charges and, second, by controlling the proton-induced effects on an intermediate step of the activation sequence.
null
293
40,813
0
false
null
null
We conclude that calcium ions antagonize the effects of extracellular protons on the gating properties of α1G in two ways: first, by competing for the binding to negative surface charges and, second, by controlling the proton-induced effects on an intermediate step of the activation sequence.
true
true
true
true
true
7,031
14
DISCUSSION
0
null
null
12,743,167
null
In the first mechanism Ca2+ and protons have equivalent effects, since both ions neutralize negative surface charges and shift all voltage-dependent processes of the channel toward positive potentials.
null
201
40,814
0
false
null
null
In the first mechanism Ca2+ and protons have equivalent effects, since both ions neutralize negative surface charges and shift all voltage-dependent processes of the channel toward positive potentials.
true
true
true
true
true
7,031
14
DISCUSSION
0
null
null
12,743,167
null
The inhibition of channel activation by the binding of protons through the second mechanism is weakened by the presence of Ca2+, which could be due to a decreased proton affinity or a modulation of the effects downstream of proton binding.
null
239
40,815
0
false
null
null
The inhibition of channel activation by the binding of protons through the second mechanism is weakened by the presence of Ca2+, which could be due to a decreased proton affinity or a modulation of the effects downstream of proton binding.
true
true
true
true
true
7,031
14
DISCUSSION
0
null
null
12,743,167
null
This may explain why the increase of [Ca2+]e prevents the decreased voltage sensitivity, the “extra” voltage shift of the activation induced by protons that is observed in Ca2+ free conditions (Fig.
null
198
40,816
0
false
null
null
This may explain why the increase of [Ca2+]e prevents the decreased voltage sensitivity, the “extra” voltage shift of the activation induced by protons that is observed in Ca2+ free conditions (Fig.
true
true
true
true
true
7,031
14
DISCUSSION
0
null
null
12,743,167
null
4) and the smaller proton-induced shift of the activation curves with respect to that of the voltage dependence of the deactivation kinetics.
null
141
40,817
0
false
null
null
4) and the smaller proton-induced shift of the activation curves with respect to that of the voltage dependence of the deactivation kinetics.
false
false
true
true
false
7,031