Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
list
pmid
int64
cited_id
string
sentences
string
all_sent_cites
list
sent_len
int64
sentence_batch_index
int64
sent_has_citation
float64
qc_fail
bool
cited_sentence
string
cites_in_sentence
list
cln_sentence
string
is_cap
bool
is_alpha
bool
ends_wp
bool
cit_qc
bool
lgtm
bool
__index_level_0__
int64
0
INTRODUCTION
1
1
[ "b1", "b12", "b8", "b13", "b14", "b12", "b14", "b1", "b12", "b15", "b1", "b9", "b12", "b15", "b20", "b1", "b9", "b21" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
The looped organization of bacterial nucleoid, which is suggested by the existence of supercoiling-independent looped domains, is presumably responsible for the long-range, higher-order architecture of nucleoid DNA (8,13,14).
[ "1", "12", "8", "13", "14", "12", "14", "1", "12", "15", "1", "9", "12", "15", "20", "1", "9", "21" ]
225
8,800
0
false
The looped organization of bacterial nucleoid, which is suggested by the existence of supercoiling-independent looped domains, is presumably responsible for the long-range, higher-order architecture of nucleoid DNA.
[ "8,13,14" ]
The looped organization of bacterial nucleoid, which is suggested by the existence of supercoiling-independent looped domains, is presumably responsible for the long-range, higher-order architecture of nucleoid DNA.
true
true
true
true
true
1,411
0
INTRODUCTION
1
1
[ "b1", "b12", "b8", "b13", "b14", "b12", "b14", "b1", "b12", "b15", "b1", "b9", "b12", "b15", "b20", "b1", "b9", "b21" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
The short-range structure might be important in restraining DNA in a negative-supercoiled state (12–14).
[ "1", "12", "8", "13", "14", "12", "14", "1", "12", "15", "1", "9", "12", "15", "20", "1", "9", "21" ]
104
8,801
0
false
The short-range structure might be important in restraining DNA in a negative-supercoiled state.
[ "12–14" ]
The short-range structure might be important in restraining DNA in a negative-supercoiled state.
true
true
true
true
true
1,411
0
INTRODUCTION
1
1
[ "b1", "b12", "b8", "b13", "b14", "b12", "b14", "b1", "b12", "b15", "b1", "b9", "b12", "b15", "b20", "b1", "b9", "b21" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
In eukaryotic cells, chromosome DNA is coated with at least an equal mass of proteins, forming a complex termed chromatin (1,12,15).
[ "1", "12", "8", "13", "14", "12", "14", "1", "12", "15", "1", "9", "12", "15", "20", "1", "9", "21" ]
132
8,802
0
false
In eukaryotic cells, chromosome DNA is coated with at least an equal mass of proteins, forming a complex termed chromatin.
[ "1,12,15" ]
In eukaryotic cells, chromosome DNA is coated with at least an equal mass of proteins, forming a complex termed chromatin.
true
true
true
true
true
1,411
0
INTRODUCTION
1
1
[ "b1", "b12", "b8", "b13", "b14", "b12", "b14", "b1", "b12", "b15", "b1", "b9", "b12", "b15", "b20", "b1", "b9", "b21" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
Proteins, such as DNA topoisomerases, histones, histone-like proteins and chromatin-associated proteins, have been suggested to play important roles in both the regulation and maintenance of chromatin structure (1,9–12,15–20).
[ "1", "12", "8", "13", "14", "12", "14", "1", "12", "15", "1", "9", "12", "15", "20", "1", "9", "21" ]
226
8,803
0
false
Proteins, such as DNA topoisomerases, histones, histone-like proteins and chromatin-associated proteins, have been suggested to play important roles in both the regulation and maintenance of chromatin structure.
[ "1,9–12,15–20" ]
Proteins, such as DNA topoisomerases, histones, histone-like proteins and chromatin-associated proteins, have been suggested to play important roles in both the regulation and maintenance of chromatin structure.
true
true
true
true
true
1,411
0
INTRODUCTION
1
1
[ "b1", "b12", "b8", "b13", "b14", "b12", "b14", "b1", "b12", "b15", "b1", "b9", "b12", "b15", "b20", "b1", "b9", "b21" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
Importantly, these proteins not only play roles in structuring chromatin, but also in regulating DNA metabolism, such as replication and transcription (1,9,21).
[ "1", "12", "8", "13", "14", "12", "14", "1", "12", "15", "1", "9", "12", "15", "20", "1", "9", "21" ]
160
8,804
0
false
Importantly, these proteins not only play roles in structuring chromatin, but also in regulating DNA metabolism, such as replication and transcription.
[ "1,9,21" ]
Importantly, these proteins not only play roles in structuring chromatin, but also in regulating DNA metabolism, such as replication and transcription.
true
true
true
true
true
1,411
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
In the short-range nucleosome structure, DNA–histone complexes are the fundamental units of eukaryotic chromatin responsible for the first order of DNA packing.
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
160
8,805
0
false
In the short-range nucleosome structure, DNA–histone complexes are the fundamental units of eukaryotic chromatin responsible for the first order of DNA packing.
[]
In the short-range nucleosome structure, DNA–histone complexes are the fundamental units of eukaryotic chromatin responsible for the first order of DNA packing.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
Each nucleosome associates with one histone H1 molecule and the bead-like structure coils into a 30 nm solenoid fiber.
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
118
8,806
0
false
Each nucleosome associates with one histone H1 molecule and the bead-like structure coils into a 30 nm solenoid fiber.
[]
Each nucleosome associates with one histone H1 molecule and the bead-like structure coils into a 30 nm solenoid fiber.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
These fibers are then further folded into higher-order structures.
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
66
8,807
0
false
These fibers are then further folded into higher-order structures.
[]
These fibers are then further folded into higher-order structures.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
A radial loop model has been proposed for the supramolecular organization of eukaryotic chromosome (15,20,22).
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
110
8,808
0
false
A radial loop model has been proposed for the supramolecular organization of eukaryotic chromosome.
[ "15,20,22" ]
A radial loop model has been proposed for the supramolecular organization of eukaryotic chromosome.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
In this model, chromosome DNA is organized into large loops (estimated as 50 to 100 kb in length) by periodic attachment to the high-salt-insoluble, protein-based nuclear matrix/scaffold (9,20,22–24).
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
200
8,809
0
false
In this model, chromosome DNA is organized into large loops (estimated as 50 to 100 kb in length) by periodic attachment to the high-salt-insoluble, protein-based nuclear matrix/scaffold.
[ "9,20,22–24" ]
In this model, chromosome DNA is organized into large loops by periodic attachment to the high-salt-insoluble, protein-based nuclear matrix/scaffold.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
The matrix/scaffold-associated regions (M/SARs) are repeated cis-acting DNA elements forming the bases of looped domains (9,22–25).
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
131
8,810
0
false
The matrix/scaffold-associated regions (M/SARs) are repeated cis-acting DNA elements forming the bases of looped domains.
[ "9,22–25" ]
The matrix/scaffold-associated regions (M/SARs) are repeated cis-acting DNA elements forming the bases of looped domains.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
DNA TOP2 and other matrix-associated proteins have been suggested to interact with M/SAR sequences and form the protein complexes for loop anchorage sites (11,22,25,26).
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
169
8,811
0
false
DNA TOP2 and other matrix-associated proteins have been suggested to interact with M/SAR sequences and form the protein complexes for loop anchorage sites.
[ "11,22,25,26" ]
DNA TOP2 and other matrix-associated proteins have been suggested to interact with M/SAR sequences and form the protein complexes for loop anchorage sites.
true
true
true
true
true
1,412
1
INTRODUCTION
1
15
[ "b15", "b20", "b22", "b9", "b20", "b22", "b24", "b9", "b22", "b25", "b11", "b22", "b25", "b26", "b11", "b17", "b27", "b28" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
Eukaryotic TOP2-mediated excision of DNA loops has therefore been extensively used to study the organization of chromosomal long-range structure (11,17,27,28).
[ "15", "20", "22", "9", "20", "22", "24", "9", "22", "25", "11", "22", "25", "26", "11", "17", "27", "28" ]
159
8,812
0
false
Eukaryotic TOP2-mediated excision of DNA loops has therefore been extensively used to study the organization of chromosomal long-range structure.
[ "11,17,27,28" ]
Eukaryotic TOP2-mediated excision of DNA loops has therefore been extensively used to study the organization of chromosomal long-range structure.
true
true
true
true
true
1,412
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
Several studies have revealed that many histone-like components, such as H-NS, HU and IHF, participate in the organization of short-range structure of bacterial nucleoid (8,12).
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
177
8,813
0
false
Several studies have revealed that many histone-like components, such as H-NS, HU and IHF, participate in the organization of short-range structure of bacterial nucleoid.
[ "8,12" ]
Several studies have revealed that many histone-like components, such as H-NS, HU and IHF, participate in the organization of short-range structure of bacterial nucleoid.
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
Although the presence of long-range, constrained DNA supercoiling domains in prokaryotic nucleoid similar to those in eukaryotic cells has been suggested from a number of observations (3,6,13,29–31), our knowledge of the cis- and trans-components maintaining the supramolecular looped domains of bacterial nucleoid DNA a...
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
393
8,814
0
false
Although the presence of long-range, constrained DNA supercoiling domains in prokaryotic nucleoid similar to those in eukaryotic cells has been suggested from a number of observations, our knowledge of the cis- and trans-components maintaining the supramolecular looped domains of bacterial nucleoid DNA and the factors ...
[ "3,6,13,29–31", "3,6,13" ]
Although the presence of long-range, constrained DNA supercoiling domains in prokaryotic nucleoid similar to those in eukaryotic cells has been suggested from a number of observations, our knowledge of the cis- and trans-components maintaining the supramolecular looped domains of bacterial nucleoid DNA and the factors ...
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
The domain structure was apparent in early electron microscope (EM) images of nucleoids in disrupted Escherichia coli (6,30,31) and in later atomic force microscopy (AFM) images (14,32).
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
186
8,815
0
false
The domain structure was apparent in early electron microscope (EM) images of nucleoids in disrupted Escherichia coli and in later atomic force microscopy (AFM) images.
[ "6,30,31", "14,32" ]
The domain structure was apparent in early electron microscope (EM) images of nucleoids in disrupted Escherichia coli and in later atomic force microscopy (AFM) images.
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
It is important to note that, although the nature of the cellular components at the bases of the potential looped arrangements is not known, each DNA loop has been shown to be topologically independent (2,13).
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
209
8,816
0
false
It is important to note that, although the nature of the cellular components at the bases of the potential looped arrangements is not known, each DNA loop has been shown to be topologically independent.
[ "2,13" ]
It is important to note that, although the nature of the cellular components at the bases of the potential looped arrangements is not known, each DNA loop has been shown to be topologically independent.
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
Subsequent studies, including measuring the output of supercoil-sensitive promoters, site-specific recombination between distinct chromosomal sites, and sequence-specific DNA localization, provided information on the dynamic and spatial aspects of the nucleoid looped organization (33–37).
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
289
8,817
0
false
Subsequent studies, including measuring the output of supercoil-sensitive promoters, site-specific recombination between distinct chromosomal sites, and sequence-specific DNA localization, provided information on the dynamic and spatial aspects of the nucleoid looped organization.
[ "33–37" ]
Subsequent studies, including measuring the output of supercoil-sensitive promoters, site-specific recombination between distinct chromosomal sites, and sequence-specific DNA localization, provided information on the dynamic and spatial aspects of the nucleoid looped organization.
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
The involvement of bacterial topoisomerase IIs (Topo IIs) has also been suggested from density gradient studies showing that the quinolone antibiotic, oxolinic acid, causes cleavage of nucleoid DNA into large DNA fragments (38,39).
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
231
8,818
0
false
The involvement of bacterial topoisomerase IIs (Topo IIs) has also been suggested from density gradient studies showing that the quinolone antibiotic, oxolinic acid, causes cleavage of nucleoid DNA into large DNA fragments.
[ "38,39" ]
The involvement of bacterial topoisomerase IIs (Topo IIs) has also been suggested from density gradient studies showing that the quinolone antibiotic, oxolinic acid, causes cleavage of nucleoid DNA into large DNA fragments.
true
true
true
true
true
1,413
2
INTRODUCTION
1
8
[ "b8", "b12", "b3", "b6", "b13", "b29", "b31", "b3", "b6", "b13", "b6", "b30", "b31", "b14", "b32", "b2", "b13", "b33", "b37", "b38", "b39" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
However, the factors involved in the regulation of the long-range architecture of bacterial nucleoid remain largely unexplored.
[ "8", "12", "3", "6", "13", "29", "31", "3", "6", "13", "6", "30", "31", "14", "32", "2", "13", "33", "37", "38", "39" ]
127
8,819
0
false
However, the factors involved in the regulation of the long-range architecture of bacterial nucleoid remain largely unexplored.
[]
However, the factors involved in the regulation of the long-range architecture of bacterial nucleoid remain largely unexplored.
true
true
true
true
true
1,413
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Two type II topoisomerases, DNA gyrase and topoisomerase IV (Topo IV), have been identified, and act in concert with topoisomerase
[ "40", "40", "42", "11", "27", "28" ]
130
8,820
0
false
Two type II topoisomerases, DNA gyrase and topoisomerase IV (Topo IV), have been identified, and act in concert with topoisomerase
[]
Two type II topoisomerases, DNA gyrase and topoisomerase IV (Topo IV), have been identified, and act in concert with topoisomerase
true
true
false
true
false
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
I (TopA), making an important contribution to the steady-state levels of supercoiling in E.coli (40).
[ "40", "40", "42", "11", "27", "28" ]
101
8,821
1
false
I (TopA), making an important contribution to the steady-state levels of supercoiling in E.coli.
[ "40" ]
I (TopA), making an important contribution to the steady-state levels of supercoiling in E.coli.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
In addition, both Topo IIs have been found to be targets for many quinolone antibiotics (40–42).
[ "40", "40", "42", "11", "27", "28" ]
96
8,822
0
false
In addition, both Topo IIs have been found to be targets for many quinolone antibiotics.
[ "40–42" ]
In addition, both Topo IIs have been found to be targets for many quinolone antibiotics.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
In mammalian cells, TOP2 excises chromosomal DNA loops (∼50 to 100 kb) in cells treated with TOP2-targeting drugs (11,27,28).
[ "40", "40", "42", "11", "27", "28" ]
125
8,823
0
false
In mammalian cells, TOP2 excises chromosomal DNA loops (∼50 to 100 kb) in cells treated with TOP2-targeting drugs.
[ "11,27,28" ]
In mammalian cells, TOP2 excises chromosomal DNA loops in cells treated with TOP2-targeting drugs.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Here, we treated bacteria with a quinolone, norfloxacin, to induce DNA fragmentation of nucleoid DNA and examined the relative contribution of gyrase and Topo IV to norfloxacin-induced excision of high molecular weight (HMW) nucleoid DNA fragments.
[ "40", "40", "42", "11", "27", "28" ]
248
8,824
0
false
Here, we treated bacteria with a quinolone, norfloxacin, to induce DNA fragmentation of nucleoid DNA and examined the relative contribution of gyrase and Topo IV to norfloxacin-induced excision of high molecular weight (HMW) nucleoid DNA fragments.
[]
Here, we treated bacteria with a quinolone, norfloxacin, to induce DNA fragmentation of nucleoid DNA and examined the relative contribution of gyrase and Topo IV to norfloxacin-induced excision of high molecular weight (HMW) nucleoid DNA fragments.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
First, we showed that bacterial nucleoid DNA was rapidly cleaved into loop-sized DNA fragments (∼50 to 100 kb) by norfloxacin treatment, indicating the potential existence of nucleoid DNA loops.
[ "40", "40", "42", "11", "27", "28" ]
194
8,825
0
false
First, we showed that bacterial nucleoid DNA was rapidly cleaved into loop-sized DNA fragments (∼50 to 100 kb) by norfloxacin treatment, indicating the potential existence of nucleoid DNA loops.
[]
First, we showed that bacterial nucleoid DNA was rapidly cleaved into loop-sized DNA fragments by norfloxacin treatment, indicating the potential existence of nucleoid DNA loops.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
We then examined whether this effect was mediated by bacterial Topo IIs.
[ "40", "40", "42", "11", "27", "28" ]
72
8,826
0
false
We then examined whether this effect was mediated by bacterial Topo IIs.
[]
We then examined whether this effect was mediated by bacterial Topo IIs.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
This was demonstrated to be the case by the tight association of proteins with HMW DNA fragments, the reversible nature of DNA loop excision, and the ability of coumermycin A1 to antagonize the fragmentation.
[ "40", "40", "42", "11", "27", "28" ]
208
8,827
0
false
This was demonstrated to be the case by the tight association of proteins with HMW DNA fragments, the reversible nature of DNA loop excision, and the ability of coumermycin A1 to antagonize the fragmentation.
[]
This was demonstrated to be the case by the tight association of proteins with HMW DNA fragments, the reversible nature of DNA loop excision, and the ability of coumermycin A1 to antagonize the fragmentation.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
We also determined that DNA gyrase was more active in the generation of loop-sized HMW DNA fragments than DNA Topo IV.
[ "40", "40", "42", "11", "27", "28" ]
118
8,828
0
false
We also determined that DNA gyrase was more active in the generation of loop-sized HMW DNA fragments than DNA Topo IV.
[]
We also determined that DNA gyrase was more active in the generation of loop-sized HMW DNA fragments than DNA Topo IV.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
In addition, studies using mutant strains suggested that E.coli TopA and structural maintenance of chromosome (SMC) proteins might also contribute to the overall organization of nucleoid DNA loops.
[ "40", "40", "42", "11", "27", "28" ]
197
8,829
0
false
In addition, studies using mutant strains suggested that E.coli TopA and structural maintenance of chromosome (SMC) proteins might also contribute to the overall organization of nucleoid DNA loops.
[]
In addition, studies using mutant strains suggested that E.coli TopA and structural maintenance of chromosome (SMC) proteins might also contribute to the overall organization of nucleoid DNA loops.
true
true
true
true
true
1,414
3
INTRODUCTION
1
40
[ "b40", "b40", "b42", "b11", "b27", "b28" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Taken together, our data suggest the existence of Topo II-modulated supercoiling loop domains in higher-order nucleoid DNA organization in prokaryotic cells.
[ "40", "40", "42", "11", "27", "28" ]
157
8,830
0
false
Taken together, our data suggest the existence of Topo II-modulated supercoiling loop domains in higher-order nucleoid DNA organization in prokaryotic cells.
[]
Taken together, our data suggest the existence of Topo II-modulated supercoiling loop domains in higher-order nucleoid DNA organization in prokaryotic cells.
true
true
true
true
true
1,414
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
The length of DNA represents a great topological packaging challenge for any given cell size.
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
93
8,831
0
false
The length of DNA represents a great topological packaging challenge for any given cell size.
[]
The length of DNA represents a great topological packaging challenge for any given cell size.
true
true
true
true
true
1,415
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
In eukaryotic cells, TOP2-mediated excision of DNA loops (∼50 to 100 kb) using TOP2-targeting drugs has been extensively used to study the organization of chromosomal long-range structure (11,17,27,28).
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
202
8,832
0
false
In eukaryotic cells, TOP2-mediated excision of DNA loops (∼50 to 100 kb) using TOP2-targeting drugs has been extensively used to study the organization of chromosomal long-range structure.
[ "11,17,27,28" ]
In eukaryotic cells, TOP2-mediated excision of DNA loops using TOP2-targeting drugs has been extensively used to study the organization of chromosomal long-range structure.
true
true
true
true
true
1,415
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
Here, we found that, in bacteria, norfloxacin-induced Topo II-mediated excision of chromosomal DNA into HMW DNA loop fragments with a non-random, limited loop-size (∼50 to 100 kb).
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
180
8,833
0
false
Here, we found that, in bacteria, norfloxacin-induced Topo II-mediated excision of chromosomal DNA into HMW DNA loop fragments with a non-random, limited loop-size (∼50 to 100 kb).
[]
Here, we found that, in bacteria, norfloxacin-induced Topo II-mediated excision of chromosomal DNA into HMW DNA loop fragments with a non-random, limited loop-size.
true
true
true
true
true
1,415
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
We also demonstrated that DNA gyrase, rather than DNA Topo IV, was the main Topo II responsible for the norfloxacin-induced excision of nucleoid DNA into loop-sized HMW DNA fragments.
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
183
8,834
0
false
We also demonstrated that DNA gyrase, rather than DNA Topo IV, was the main Topo II responsible for the norfloxacin-induced excision of nucleoid DNA into loop-sized HMW DNA fragments.
[]
We also demonstrated that DNA gyrase, rather than DNA Topo IV, was the main Topo II responsible for the norfloxacin-induced excision of nucleoid DNA into loop-sized HMW DNA fragments.
true
true
true
true
true
1,415
0
DISCUSSION
1
38
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
However, consistent with a previous report using sedimentation analysis (38), Topo IV was located at most widely spread sites on nucleoid than gyrase.
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
150
8,835
1
false
However, consistent with a previous report using sedimentation analysis, Topo IV was located at most widely spread sites on nucleoid than gyrase.
[ "38" ]
However, consistent with a previous report using sedimentation analysis, Topo IV was located at most widely spread sites on nucleoid than gyrase.
true
true
true
true
true
1,415
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
Our demonstration that bacterial Topo IIs cleaved nucleoid into loop-sized HMW DNA fragments suggests that chromatin structure at the level of the higher-order DNA loop structure is probably conserved in nucleoid DNA in prokaryotes.
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
232
8,836
0
false
Our demonstration that bacterial Topo IIs cleaved nucleoid into loop-sized HMW DNA fragments suggests that chromatin structure at the level of the higher-order DNA loop structure is probably conserved in nucleoid DNA in prokaryotes.
[]
Our demonstration that bacterial Topo IIs cleaved nucleoid into loop-sized HMW DNA fragments suggests that chromatin structure at the level of the higher-order DNA loop structure is probably conserved in nucleoid DNA in prokaryotes.
true
true
true
true
true
1,415
0
DISCUSSION
1
11
[ "b11", "b17", "b27", "b28", "b38", "b3", "b6", "b13", "b29", "b31", "b38", "b39" ]
16,757,578
pmid-15952899|pmid-15063845|pmid-15948945|pmid-3047111|pmid-15305055|pmid-15063845|pmid-15305055|pmid-15952899|pmid-15063845|pmid-12540921|pmid-15952899|pmid-15519691|pmid-15063845|pmid-12540921|pmid-6397469|pmid-15952899|pmid-15519691|pmid-15659173|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pm...
This notion is supported by early demonstrations of independent supercoiling domains (3,6,13,29–31) and the Topo II-mediated cleavage of nucleoid using oxolinic acid and ciprofloxacin (38,39).
[ "11", "17", "27", "28", "38", "3", "6", "13", "29", "31", "38", "39" ]
192
8,837
0
false
This notion is supported by early demonstrations of independent supercoiling domains and the Topo II-mediated cleavage of nucleoid using oxolinic acid and ciprofloxacin.
[ "3,6,13,29–31", "38,39" ]
This notion is supported by early demonstrations of independent supercoiling domains and the Topo II-mediated cleavage of nucleoid using oxolinic acid and ciprofloxacin.
true
true
true
true
true
1,415
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
Norfloxacin, oxolinic acid and ciprofloxacin are all quinolone antibiotics.
[ "38", "39", "38", "43" ]
75
8,838
0
false
Norfloxacin, oxolinic acid and ciprofloxacin are all quinolone antibiotics.
[]
Norfloxacin, oxolinic acid and ciprofloxacin are all quinolone antibiotics.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
However, the average size of norfloxacin-induced HMW DNA fragments reported in our study (∼50 kb), while similar to that of the fragments induced by ciprofloxacin (38), was smaller than for those induced by oxolinic acid (∼100 kb) (39).
[ "38", "39", "38", "43" ]
236
8,839
1
false
However, the average size of norfloxacin-induced HMW DNA fragments reported in our study (∼50 kb), while similar to that of the fragments induced by ciprofloxacin, was smaller than for those induced by oxolinic acid (∼100 kb).
[ "38", "39" ]
However, the average size of norfloxacin-induced HMW DNA fragments reported in our study (∼50 kb), while similar to that of the fragments induced by ciprofloxacin, was smaller than for those induced by oxolinic acid (∼100 kb).
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
This difference can be explained by the fact that both norfloxacin and ciprofloxacin target gyrase and DNA topoisomerase IV, while oxolinic acid mainly targets gyrase (38,43).
[ "38", "39", "38", "43" ]
175
8,840
0
false
This difference can be explained by the fact that both norfloxacin and ciprofloxacin target gyrase and DNA topoisomerase IV, while oxolinic acid mainly targets gyrase.
[ "38,43" ]
This difference can be explained by the fact that both norfloxacin and ciprofloxacin target gyrase and DNA topoisomerase IV, while oxolinic acid mainly targets gyrase.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
It is therefore reasonable to speculate that the smaller DNA fragments generated by norfloxacin or ciprofloxacin are due to additional Topo IV-mediated DNA cleavage of nucleoid DNA.
[ "38", "39", "38", "43" ]
181
8,841
0
false
It is therefore reasonable to speculate that the smaller DNA fragments generated by norfloxacin or ciprofloxacin are due to additional Topo IV-mediated DNA cleavage of nucleoid DNA.
[]
It is therefore reasonable to speculate that the smaller DNA fragments generated by norfloxacin or ciprofloxacin are due to additional Topo IV-mediated DNA cleavage of nucleoid DNA.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
The different distributions of gyrase and Topo IV on nucleoid might well correlate with their different cellular functions.
[ "38", "39", "38", "43" ]
123
8,842
0
false
The different distributions of gyrase and Topo IV on nucleoid might well correlate with their different cellular functions.
[]
The different distributions of gyrase and Topo IV on nucleoid might well correlate with their different cellular functions.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
As mentioned above, TOP2-mediated excision of chromosomal DNA loops has been used in mammalian system to probe the structure of the higher-order loop organization of the chromosome.
[ "38", "39", "38", "43" ]
181
8,843
0
false
As mentioned above, TOP2-mediated excision of chromosomal DNA loops has been used in mammalian system to probe the structure of the higher-order loop organization of the chromosome.
[]
As mentioned above, TOP2-mediated excision of chromosomal DNA loops has been used in mammalian system to probe the structure of the higher-order loop organization of the chromosome.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
In addition, TOP2 has been suggested to be located at the base of the chromosome loops.
[ "38", "39", "38", "43" ]
87
8,844
0
false
In addition, TOP2 has been suggested to be located at the base of the chromosome loops.
[]
In addition, TOP2 has been suggested to be located at the base of the chromosome loops.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
We found that gyrase was the main enzyme responsible for the generation of loop-size DNA fragments induced by norfloxacin.
[ "38", "39", "38", "43" ]
122
8,845
0
false
We found that gyrase was the main enzyme responsible for the generation of loop-size DNA fragments induced by norfloxacin.
[]
We found that gyrase was the main enzyme responsible for the generation of loop-size DNA fragments induced by norfloxacin.
true
true
true
true
true
1,416
1
DISCUSSION
1
38
[ "b38", "b39", "b38", "b43" ]
16,757,578
pmid-12540921|pmid-6397469|pmid-1322207|pmid-15519691|pmid-6397469|pmid-1322207|pmid-11186332|pmid-15519691|pmid-1322207|pmid-9794825|pmid-10651244|pmid-1322207|pmid-9794825|pmid-6679151|pmid-10651244|pmid-8855390|pmid-10385624|pmid-15087487|pmid-8636997|pmid-226717|pmid-8636997|pmid-9334322
It is therefore reasonable to speculate that DNA gyrase, rather than Topo IV, is the Topo II that actively participates in the regulation of loop organization and is located at the base of the nucleoid DNA loops.
[ "38", "39", "38", "43" ]
212
8,846
0
false
It is therefore reasonable to speculate that DNA gyrase, rather than Topo IV, is the Topo II that actively participates in the regulation of loop organization and is located at the base of the nucleoid DNA loops.
[]
It is therefore reasonable to speculate that DNA gyrase, rather than Topo IV, is the Topo II that actively participates in the regulation of loop organization and is located at the base of the nucleoid DNA loops.
true
true
true
true
true
1,416
2
DISCUSSION
1
14
[ "b14", "b32", "b62", "b11", "b27", "b28" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
AFM and EM images of nucleoid DNA and other structure-probing assays indicate the existence of non-random DNA organization in the bacterial cell (14,32,62).
[ "14", "32", "62", "11", "27", "28" ]
156
8,847
0
false
AFM and EM images of nucleoid DNA and other structure-probing assays indicate the existence of non-random DNA organization in the bacterial cell.
[ "14,32,62" ]
AFM and EM images of nucleoid DNA and other structure-probing assays indicate the existence of non-random DNA organization in the bacterial cell.
true
true
true
true
true
1,417
2
DISCUSSION
1
14
[ "b14", "b32", "b62", "b11", "b27", "b28" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
In addition, earlier reports also suggested the existence of supercoiling-independent domains on a single nucleoid.
[ "14", "32", "62", "11", "27", "28" ]
115
8,848
0
false
In addition, earlier reports also suggested the existence of supercoiling-independent domains on a single nucleoid.
[]
In addition, earlier reports also suggested the existence of supercoiling-independent domains on a single nucleoid.
true
true
true
true
true
1,417
2
DISCUSSION
1
14
[ "b14", "b32", "b62", "b11", "b27", "b28" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
As in studies of mammalian cells incubated with TOP2-targeting drugs (11,27,28), our study demonstrated that treatment of bacteria with the Topo II-targeting drug, norfloxacin, also induced loop-size DNA fragmentation of the nucleoid.
[ "14", "32", "62", "11", "27", "28" ]
234
8,849
0
false
As in studies of mammalian cells incubated with TOP2-targeting drugs, our study demonstrated that treatment of bacteria with the Topo II-targeting drug, norfloxacin, also induced loop-size DNA fragmentation of the nucleoid.
[ "11,27,28" ]
As in studies of mammalian cells incubated with TOP2-targeting drugs, our study demonstrated that treatment of bacteria with the Topo II-targeting drug, norfloxacin, also induced loop-size DNA fragmentation of the nucleoid.
true
true
true
true
true
1,417
2
DISCUSSION
1
14
[ "b14", "b32", "b62", "b11", "b27", "b28" ]
16,757,578
pmid-15948945|pmid-15063845|pmid-6246488|pmid-1108025|pmid-3047111|pmid-6254668|pmid-4598641|pmid-6246488|pmid-1108025|pmid-3047111|pmid-1108025|pmid-4206502|pmid-4598641|pmid-15305055|pmid-15060178|pmid-6165987|pmid-3047111|pmid-8631670|pmid-10652275|pmid-8636997|pmid-226717|pmid-15305055|pmid-15060178|pmid-15534364|p...
Thus, the radial loop model proposed for higher-order chromatin structure in mammalian chromosomes might also be suitable for the long-range structure of bacterial nucleoid.
[ "14", "32", "62", "11", "27", "28" ]
173
8,850
0
false
Thus, the radial loop model proposed for higher-order chromatin structure in mammalian chromosomes might also be suitable for the long-range structure of bacterial nucleoid.
[]
Thus, the radial loop model proposed for higher-order chromatin structure in mammalian chromosomes might also be suitable for the long-range structure of bacterial nucleoid.
true
true
true
true
true
1,417
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Two type II topoisomerases, gyrase and topoisomerase IV, have been identified in E.coli (36,40,63).
[ "36", "40", "63", "43", "58", "59", "64" ]
99
8,851
0
false
Two type II topoisomerases, gyrase and topoisomerase IV, have been identified in E.coli.
[ "36,40,63" ]
Two type II topoisomerases, gyrase and topoisomerase IV, have been identified in E.coli.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Purified gyrase and Topo IV have different catalytic mechanisms and biochemical activities (43,58,59,64).
[ "36", "40", "63", "43", "58", "59", "64" ]
105
8,852
0
false
Purified gyrase and Topo IV have different catalytic mechanisms and biochemical activities.
[ "43,58,59,64" ]
Purified gyrase and Topo IV have different catalytic mechanisms and biochemical activities.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
The major biochemical activity identified for gyrase is the introduction of negative supercoiling, which can efficiently relax the positive supercoiling tension generated from DNA metabolism.
[ "36", "40", "63", "43", "58", "59", "64" ]
191
8,853
0
false
The major biochemical activity identified for gyrase is the introduction of negative supercoiling, which can efficiently relax the positive supercoiling tension generated from DNA metabolism.
[]
The major biochemical activity identified for gyrase is the introduction of negative supercoiling, which can efficiently relax the positive supercoiling tension generated from DNA metabolism.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Topo IV, on the other hand, does not have great supercoiling activity and is mainly involved in the catenation/decatenation reaction.
[ "36", "40", "63", "43", "58", "59", "64" ]
133
8,854
0
false
Topo IV, on the other hand, does not have great supercoiling activity and is mainly involved in the catenation/decatenation reaction.
[]
Topo IV, on the other hand, does not have great supercoiling activity and is mainly involved in the catenation/decatenation reaction.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
It is therefore generally believed that gyrase contributes mainly to house-keeping functions involving the regulation of supercoiling during DNA metabolism processes.
[ "36", "40", "63", "43", "58", "59", "64" ]
166
8,855
0
false
It is therefore generally believed that gyrase contributes mainly to house-keeping functions involving the regulation of supercoiling during DNA metabolism processes.
[]
It is therefore generally believed that gyrase contributes mainly to house-keeping functions involving the regulation of supercoiling during DNA metabolism processes.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Topo IV, on the other hand, like mammalian TOP2α, plays a more important role in chromosome segregation.
[ "36", "40", "63", "43", "58", "59", "64" ]
104
8,856
0
false
Topo IV, on the other hand, like mammalian TOP2α, plays a more important role in chromosome segregation.
[]
Topo IV, on the other hand, like mammalian TOP2α, plays a more important role in chromosome segregation.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
On the basis of the above properties, one would consider that DNA gyrase, rather than Topo IV, would be the enzyme located at the base of DNA loops to regulate the supercoiling tension of topologically independent loops.
[ "36", "40", "63", "43", "58", "59", "64" ]
220
8,857
0
false
On the basis of the above properties, one would consider that DNA gyrase, rather than Topo IV, would be the enzyme located at the base of DNA loops to regulate the supercoiling tension of topologically independent loops.
[]
On the basis of the above properties, one would consider that DNA gyrase, rather than Topo IV, would be the enzyme located at the base of DNA loops to regulate the supercoiling tension of topologically independent loops.
true
true
true
true
true
1,418
3
DISCUSSION
1
36
[ "b36", "b40", "b63", "b43", "b58", "b59", "b64" ]
16,757,578
pmid-10713132|pmid-10713132|pmid-9710672|pmid-10651244|pmid-10385624|pmid-15087487|pmid-9781880|pmid-10713132|pmid-9765303|pmid-9334322|pmid-8940171|pmid-7590259|pmid-11090135
Our results showing that DNA gyrase was the main enzyme responsible for the norfloxacin-induced excision of nucleoid DNA loops support this notion.
[ "36", "40", "63", "43", "58", "59", "64" ]
147
8,858
0
false
Our results showing that DNA gyrase was the main enzyme responsible for the norfloxacin-induced excision of nucleoid DNA loops support this notion.
[]
Our results showing that DNA gyrase was the main enzyme responsible for the norfloxacin-induced excision of nucleoid DNA loops support this notion.
true
true
true
true
true
1,418
4
DISCUSSION
1
1
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
In the present study, we also examined the involvement of MukB, TopA
[ "1", "65", "32", "62" ]
68
8,859
0
false
In the present study, we also examined the involvement of MukB, TopA
[]
In the present study, we also examined the involvement of MukB, TopA
true
true
false
true
false
1,419
4
DISCUSSION
1
1
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
and TopB in the norfloxacin-induced HMW DNA fragmentation of the E.coli genome.
[ "1", "65", "32", "62" ]
79
8,860
0
false
and TopB in the norfloxacin-induced HMW DNA fragmentation of the E.coli genome.
[]
and TopB in the norfloxacin-induced HMW DNA fragmentation of the E.coli genome.
false
true
true
true
false
1,419
4
DISCUSSION
1
1
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
In agreement with the roles of condensins in eukaryotic higher-order chromatin (1), our results showed that MukB protein was a critical component for the organization of nucleoid DNA loop structure, as indicated by the lack of generation of loop-sized HMW DNA fragments by norfloxacin in the absence of MukB function, an...
[ "1", "65", "32", "62" ]
350
8,861
1
false
In agreement with the roles of condensins in eukaryotic higher-order chromatin, our results showed that MukB protein was a critical component for the organization of nucleoid DNA loop structure, as indicated by the lack of generation of loop-sized HMW DNA fragments by norfloxacin in the absence of MukB function, and th...
[ "1" ]
In agreement with the roles of condensins in eukaryotic higher-order chromatin, our results showed that MukB protein was a critical component for the organization of nucleoid DNA loop structure, as indicated by the lack of generation of loop-sized HMW DNA fragments by norfloxacin in the absence of MukB function, and th...
true
true
true
true
true
1,419
4
DISCUSSION
1
65
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
Previous mutational studies have ruled out the involvement of the histone-like proteins, H-NS, HU, FIS and IHF, in the looped domain organization of the nucleoid in E.coli (65).
[ "1", "65", "32", "62" ]
177
8,862
1
false
Previous mutational studies have ruled out the involvement of the histone-like proteins, H-NS, HU, FIS and IHF, in the looped domain organization of the nucleoid in E.coli.
[ "65" ]
Previous mutational studies have ruled out the involvement of the histone-like proteins, H-NS, HU, FIS and IHF, in the looped domain organization of the nucleoid in E.coli.
true
true
true
true
true
1,419
4
DISCUSSION
1
32
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
However, mutant analysis has also revealed that tight compaction of nucleoid DNA requires Dps (32).
[ "1", "65", "32", "62" ]
99
8,863
1
false
However, mutant analysis has also revealed that tight compaction of nucleoid DNA requires Dps.
[ "32" ]
However, mutant analysis has also revealed that tight compaction of nucleoid DNA requires Dps.
true
true
true
true
true
1,419
4
DISCUSSION
1
62
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
In addition, E.coli Dps proteins form condensed complexes with DNA (62).
[ "1", "65", "32", "62" ]
72
8,864
1
false
In addition, E.coli Dps proteins form condensed complexes with DNA.
[ "62" ]
In addition, E.coli Dps proteins form condensed complexes with DNA.
true
true
true
true
true
1,419
4
DISCUSSION
1
1
[ "b1", "b65", "b32", "b62" ]
16,757,578
pmid-15952899|pmid-11698109|pmid-15060178|pmid-15534364
It should be interesting to examine the involvement of Dps in the norfloxacin-induced generation of loop-sized DNA fragments.
[ "1", "65", "32", "62" ]
125
8,865
0
false
It should be interesting to examine the involvement of Dps in the norfloxacin-induced generation of loop-sized DNA fragments.
[]
It should be interesting to examine the involvement of Dps in the norfloxacin-induced generation of loop-sized DNA fragments.
true
true
true
true
true
1,419
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
As mentioned above, the gyrase and Topo IV cleavage sites examined in our study might well represent the relative distributions of Topo IIs on nucleoid.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
152
8,866
0
false
As mentioned above, the gyrase and Topo IV cleavage sites examined in our study might well represent the relative distributions of Topo IIs on nucleoid.
[]
As mentioned above, the gyrase and Topo IV cleavage sites examined in our study might well represent the relative distributions of Topo IIs on nucleoid.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
In addition, the average DNA length of the gyrase-cleaved HMW DNA fragments (∼50 kb) in bacteria was similar to the average size (∼50 kb) of eukaryotic TOP2-excised chromosomal DNA loops.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
187
8,867
0
false
In addition, the average DNA length of the gyrase-cleaved HMW DNA fragments (∼50 kb) in bacteria was similar to the average size (∼50 kb) of eukaryotic TOP2-excised chromosomal DNA loops.
[]
In addition, the average DNA length of the gyrase-cleaved HMW DNA fragments (∼50 kb) in bacteria was similar to the average size (∼50 kb) of eukaryotic TOP2-excised chromosomal DNA loops.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
DNA gyrase might therefore be located on the matrix to which the bases of the DNA loops are attached.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
101
8,868
0
false
DNA gyrase might therefore be located on the matrix to which the bases of the DNA loops are attached.
[]
DNA gyrase might therefore be located on the matrix to which the bases of the DNA loops are attached.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
What might be the cis-DNA elements that interact with gyrase and mediate the attachment of DNA loops to the matrix?
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
115
8,869
0
false
What might be the cis-DNA elements that interact with gyrase and mediate the attachment of DNA loops to the matrix?
[]
What might be the cis-DNA elements that interact with gyrase and mediate the attachment of DNA loops to the matrix?
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
In eukaryotic cells, M/SARs on chromosomal DNA can interact with TOP2 and have been proposed to be the cis-elements in DNA at the base of chromosomal loops.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
156
8,870
0
false
In eukaryotic cells, M/SARs on chromosomal DNA can interact with TOP2 and have been proposed to be the cis-elements in DNA at the base of chromosomal loops.
[]
In eukaryotic cells, M/SARs on chromosomal DNA can interact with TOP2 and have been proposed to be the cis-elements in DNA at the base of chromosomal loops.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
DNA gyrase is also known to interact with, and cleave, DNA containing BIME sequences (66–68).
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
93
8,871
0
false
DNA gyrase is also known to interact with, and cleave, DNA containing BIME sequences.
[ "66–68" ]
DNA gyrase is also known to interact with, and cleave, DNA containing BIME sequences.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
The BIME family of bacterial highly repetitive DNA elements is found in many species of bacteria (67,69–72).
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
108
8,872
0
false
The BIME family of bacterial highly repetitive DNA elements is found in many species of bacteria.
[ "67,69–72" ]
The BIME family of bacterial highly repetitive DNA elements is found in many species of bacteria.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
Importantly, the presence of these interspersed DNA sequences located outside the coding regions suggests that BIMEs might have a potential role in defining the compact structure of bacterial nucleoid DNA.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
205
8,873
0
false
Importantly, the presence of these interspersed DNA sequences located outside the coding regions suggests that BIMEs might have a potential role in defining the compact structure of bacterial nucleoid DNA.
[]
Importantly, the presence of these interspersed DNA sequences located outside the coding regions suggests that BIMEs might have a potential role in defining the compact structure of bacterial nucleoid DNA.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
BIME sequences contain different repeated motifs and are 40–500 nt in length (67,69–72).
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
88
8,874
0
false
BIME sequences contain different repeated motifs and are 40–500 nt in length.
[ "67,69–72" ]
BIME sequences contain different repeated motifs and are 40–500 nt in length.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
Based on specific combinations of different repeated motifs, BIMEs can be further divided into two subfamilies, BIME-1 and BIME-2 (67,69–72).
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
141
8,875
0
false
Based on specific combinations of different repeated motifs, BIMEs can be further divided into two subfamilies, BIME-1 and BIME-2.
[ "67,69–72" ]
Based on specific combinations of different repeated motifs, BIMEs can be further divided into two subfamilies, BIME-1 and BIME-2.
true
true
true
true
true
1,420
5
DISCUSSION
1
66
[ "b66", "b68", "b67", "b69", "b72", "b67", "b69", "b72", "b67", "b69", "b72" ]
16,757,578
pmid-2848243|pmid-9427406|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745|pmid-8057840|pmid-8459773|pmid-2027745
Given our finding that Topo IIs contribute to the organization of nucleoid DNA loop structure, it is tempting to relate the diverse functional properties of BIMEs to those exhibited by nuclear M/SARs, in which eukaryotic TOP2s are located.
[ "66", "68", "67", "69", "72", "67", "69", "72", "67", "69", "72" ]
239
8,876
0
false
Given our finding that Topo IIs contribute to the organization of nucleoid DNA loop structure, it is tempting to relate the diverse functional properties of BIMEs to those exhibited by nuclear M/SARs, in which eukaryotic TOP2s are located.
[]
Given our finding that Topo IIs contribute to the organization of nucleoid DNA loop structure, it is tempting to relate the diverse functional properties of BIMEs to those exhibited by nuclear M/SARs, in which eukaryotic TOP2s are located.
true
true
true
true
true
1,420
6
DISCUSSION
1
66
[ "b66", "b68" ]
16,757,578
pmid-2848243|pmid-9427406
Interestingly, the affinities of the BIMEs for DNA gyrase, studied by the gel electrophoretic mobility shift assay (EMSA), have been shown to be different, with BIME-2having a higher affinity than BIME-1 (66–68).
[ "66", "68" ]
212
8,877
0
false
Interestingly, the affinities of the BIMEs for DNA gyrase, studied by the gel electrophoretic mobility shift assay (EMSA), have been shown to be different, with BIME-2having a higher affinity than BIME-1.
[ "66–68" ]
Interestingly, the affinities of the BIMEs for DNA gyrase, studied by the gel electrophoretic mobility shift assay (EMSA), have been shown to be different, with BIME-2having a higher affinity than BIME-1.
true
true
true
true
true
1,421
6
DISCUSSION
1
66
[ "b66", "b68" ]
16,757,578
pmid-2848243|pmid-9427406
Furthermore, our drug-resistant mutant analysis demonstrated that norfloxacin-induced different patterns of HMW DNA fragmentation mediated by either gyrase or Topo IV.
[ "66", "68" ]
167
8,878
0
false
Furthermore, our drug-resistant mutant analysis demonstrated that norfloxacin-induced different patterns of HMW DNA fragmentation mediated by either gyrase or Topo IV.
[]
Furthermore, our drug-resistant mutant analysis demonstrated that norfloxacin-induced different patterns of HMW DNA fragmentation mediated by either gyrase or Topo IV.
true
true
true
true
true
1,421
6
DISCUSSION
1
66
[ "b66", "b68" ]
16,757,578
pmid-2848243|pmid-9427406
Further clarification of the biochemical interactions between BIMEs and the TOP2s is required.
[ "66", "68" ]
94
8,879
0
false
Further clarification of the biochemical interactions between BIMEs and the TOP2s is required.
[]
Further clarification of the biochemical interactions between BIMEs and the TOP2s is required.
true
true
true
true
true
1,421
7
DISCUSSION
1
1
[ "b1", "b8", "b12", "b14", "b32", "b34", "b35", "b73" ]
16,757,578
pmid-15952899|pmid-15948945|pmid-15063845|pmid-15305055|pmid-15060178|pmid-15178755|pmid-15853889|pmid-15256503
Recent advances in cytological and genetic methods have suggested that different levels of chromatin structures exist in nucleoid DNA and that several DNA-interacting proteins are components of these chromatin structures (1,8,12,14,32,34,35,73).
[ "1", "8", "12", "14", "32", "34", "35", "73" ]
245
8,880
0
false
Recent advances in cytological and genetic methods have suggested that different levels of chromatin structures exist in nucleoid DNA and that several DNA-interacting proteins are components of these chromatin structures.
[ "1,8,12,14,32,34,35,73" ]
Recent advances in cytological and genetic methods have suggested that different levels of chromatin structures exist in nucleoid DNA and that several DNA-interacting proteins are components of these chromatin structures.
true
true
true
true
true
1,422
7
DISCUSSION
1
1
[ "b1", "b8", "b12", "b14", "b32", "b34", "b35", "b73" ]
16,757,578
pmid-15952899|pmid-15948945|pmid-15063845|pmid-15305055|pmid-15060178|pmid-15178755|pmid-15853889|pmid-15256503
Chromatin structure and DNA supercoiling are tightly associated with many aspects of cellular function.
[ "1", "8", "12", "14", "32", "34", "35", "73" ]
103
8,881
0
false
Chromatin structure and DNA supercoiling are tightly associated with many aspects of cellular function.
[]
Chromatin structure and DNA supercoiling are tightly associated with many aspects of cellular function.
true
true
true
true
true
1,422
7
DISCUSSION
1
1
[ "b1", "b8", "b12", "b14", "b32", "b34", "b35", "b73" ]
16,757,578
pmid-15952899|pmid-15948945|pmid-15063845|pmid-15305055|pmid-15060178|pmid-15178755|pmid-15853889|pmid-15256503
DNA topoisomerases are actively involved in both processes.
[ "1", "8", "12", "14", "32", "34", "35", "73" ]
59
8,882
0
false
DNA topoisomerases are actively involved in both processes.
[]
DNA topoisomerases are actively involved in both processes.
true
true
true
true
true
1,422
7
DISCUSSION
1
1
[ "b1", "b8", "b12", "b14", "b32", "b34", "b35", "b73" ]
16,757,578
pmid-15952899|pmid-15948945|pmid-15063845|pmid-15305055|pmid-15060178|pmid-15178755|pmid-15853889|pmid-15256503
Consistent with the above mentioned hypothesis, the patterns of Topo II-mediated cleavage of HMW DNA fragments in the presence or absence of functional SMC proteins were different in the mukB mutant.
[ "1", "8", "12", "14", "32", "34", "35", "73" ]
199
8,883
0
false
Consistent with the above mentioned hypothesis, the patterns of Topo II-mediated cleavage of HMW DNA fragments in the presence or absence of functional SMC proteins were different in the mukB mutant.
[]
Consistent with the above mentioned hypothesis, the patterns of Topo II-mediated cleavage of HMW DNA fragments in the presence or absence of functional SMC proteins were different in the mukB mutant.
true
true
true
true
true
1,422
7
DISCUSSION
1
1
[ "b1", "b8", "b12", "b14", "b32", "b34", "b35", "b73" ]
16,757,578
pmid-15952899|pmid-15948945|pmid-15063845|pmid-15305055|pmid-15060178|pmid-15178755|pmid-15853889|pmid-15256503
Further studies identifying the relative contributions of TopA, gyrase and Topo IV to nucleoid chromatin organization should help our understanding of nucleoid DNA architecture.
[ "1", "8", "12", "14", "32", "34", "35", "73" ]
177
8,884
0
false
Further studies identifying the relative contributions of TopA, gyrase and Topo IV to nucleoid chromatin organization should help our understanding of nucleoid DNA architecture.
[]
Further studies identifying the relative contributions of TopA, gyrase and Topo IV to nucleoid chromatin organization should help our understanding of nucleoid DNA architecture.
true
true
true
true
true
1,422
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
Helicases couple the energy of nucleotide hydrolysis to the unwinding of double-stranded nucleic acids.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
103
8,885
0
false
Helicases couple the energy of nucleotide hydrolysis to the unwinding of double-stranded nucleic acids.
[]
Helicases couple the energy of nucleotide hydrolysis to the unwinding of double-stranded nucleic acids.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
Many of these enzymes function as oligomers including the viral helicases T-antigen and E1, the replicative helicases of SV40 (1,2) and papillomavirus, respectively (3,4).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
171
8,886
0
false
Many of these enzymes function as oligomers including the viral helicases T-antigen and E1, the replicative helicases of SV40 and papillomavirus, respectively.
[ "1,2", "3,4" ]
Many of these enzymes function as oligomers including the viral helicases T-antigen and E1, the replicative helicases of SV40 and papillomavirus, respectively.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
These proteins are also the initiator proteins that first melt the origin DNA (ori) where they then assemble as helicases (5,6).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
128
8,887
0
false
These proteins are also the initiator proteins that first melt the origin DNA (ori) where they then assemble as helicases.
[ "5,6" ]
These proteins are also the initiator proteins that first melt the origin DNA (ori) where they then assemble as helicases.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
The melting of duplex DNA and processive unwinding are distinct processes, but there are indications of mechanistic similarities.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
129
8,888
0
false
The melting of duplex DNA and processive unwinding are distinct processes, but there are indications of mechanistic similarities.
[]
The melting of duplex DNA and processive unwinding are distinct processes, but there are indications of mechanistic similarities.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
This is based largely on a shared requirement for amino acids in the helicase domains (HDs) of SV40 and E1 that form a single-stranded DNA (ssDNA) binding site (7,8).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
166
8,889
0
false
This is based largely on a shared requirement for amino acids in the helicase domains (HDs) of SV40 and E1 that form a single-stranded DNA (ssDNA) binding site.
[ "7,8" ]
This is based largely on a shared requirement for amino acids in the helicase domains (HDs) of SV40 and E1 that form a single-stranded DNA (ssDNA) binding site.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
DNA melting occurs at specific sites defined by the origin-recognition sequence (ori) and the sequence-specific-origin binding domains (OBDs) of these initiators.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
162
8,890
0
false
DNA melting occurs at specific sites defined by the origin-recognition sequence (ori) and the sequence-specific-origin binding domains (OBDs) of these initiators.
[]
DNA melting occurs at specific sites defined by the origin-recognition sequence (ori) and the sequence-specific-origin binding domains (OBDs) of these initiators.
true
true
true
true
true
1,423
0
INTRODUCTION
1
9
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
In bovine papillomavirus (BPV-1) the E1 protein assembles in a stepwise fashion on ori (9).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
91
8,891
1
false
In bovine papillomavirus the E1 protein assembles in a stepwise fashion on ori.
[ "BPV-1", "9" ]
In bovine papillomavirus the E1 protein assembles in a stepwise fashion on ori.
true
true
true
true
true
1,423
0
INTRODUCTION
1
10
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
The initial binding of E1 as a dimer requires the assistance of the transcription factor E2 (10), which orientates subsequent oligomeric complexes in a head to tail array.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
171
8,892
1
false
The initial binding of E1 as a dimer requires the assistance of the transcription factor E2, which orientates subsequent oligomeric complexes in a head to tail array.
[ "10" ]
The initial binding of E1 as a dimer requires the assistance of the transcription factor E2, which orientates subsequent oligomeric complexes in a head to tail array.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
In the presence of ATP, oligomers from tetramer through to double hexamers have been observed (11,12).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
102
8,893
0
false
In the presence of ATP, oligomers from tetramer through to double hexamers have been observed.
[ "11,12" ]
In the presence of ATP, oligomers from tetramer through to double hexamers have been observed.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
In the absence of ATP, the E1–ori complexes that form are relatively unstable.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
78
8,894
0
false
In the absence of ATP, the E1–ori complexes that form are relatively unstable.
[]
In the absence of ATP, the E1–ori complexes that form are relatively unstable.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
Two E1 trimers melt the DNA either side of the E1-binding site.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
63
8,895
0
false
Two E1 trimers melt the DNA either side of the E1-binding site.
[]
Two E1 trimers melt the DNA either side of the E1-binding site.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
This event is ATP dependent and requires the cooperation of the OBD and an ssDNA-binding site in the E1HD.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
106
8,896
0
false
This event is ATP dependent and requires the cooperation of the OBD and an ssDNA-binding site in the E1HD.
[]
This event is ATP dependent and requires the cooperation of the OBD and an ssDNA-binding site in the E1HD.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
The final transition to the putative double hexameric replicative helicase is not understood.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
93
8,897
0
false
The final transition to the putative double hexameric replicative helicase is not understood.
[]
The final transition to the putative double hexameric replicative helicase is not understood.
true
true
true
true
true
1,423
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
However, the predicted rearrangement to two protein rings is likely to require the ongoing involvement of the ATP-modulated ssDNA-binding site in the E1 helicase domain (E1HD).
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
176
8,898
0
false
However, the predicted rearrangement to two protein rings is likely to require the ongoing involvement of the ATP-modulated ssDNA-binding site in the E1 helicase domain.
[ "E1HD" ]
However, the predicted rearrangement to two protein rings is likely to require the ongoing involvement of the ATP-modulated ssDNA-binding site in the E1 helicase domain.
true
true
true
true
true
1,423
0
INTRODUCTION
1
13
[ "b1", "b2", "b3", "b4", "b5", "b6", "b7", "b8", "b9", "b10", "b11", "b12", "b13" ]
16,893,956
pmid-3025851|pmid-3035543|pmid-8389467|pmid-8380645|pmid-2846276|pmid-8090734|pmid-16061814|pmid-16738139|pmid-14504622|pmid-8557041|pmid-16285920|pmid-10652347|pmid-2539565|pmid-9843509|pmid-9658141|pmid-9933649|pmid-10535735|pmid-10892646|pmid-9302992|pmid-15454080|pmid-15289463|pmid-15289463|pmid-9149137|pmid-113045...
In SV40, T-antigen also assembles on ori in various oligomeric states (13), but the ori melting complex structure has not been defined.
[ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13" ]
135
8,899
1
false
In SV40, T-antigen also assembles on ori in various oligomeric states, but the ori melting complex structure has not been defined.
[ "13" ]
In SV40, T-antigen also assembles on ori in various oligomeric states, but the ori melting complex structure has not been defined.
true
true
true
true
true
1,423