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PMC1044835_pbio-0030079-g005_1496.jpg | Can you identify the primary element in this image? | Significant Signal Changes in Subjects Receiving Explicit Instructions Compared to Subjects Receiving Implicit Instructions in the Three Tasks Versus RestThreshold of Z = 2.3 at voxel level and a cluster level corrected for the whole brain at p < 0.05. The two black arrows indicate two foci of activity in dorsal premot... |
PMC1044835_pbio-0030079-g005_1494.jpg | Describe the main subject of this image. | Significant Signal Changes in Subjects Receiving Explicit Instructions Compared to Subjects Receiving Implicit Instructions in the Three Tasks Versus RestThreshold of Z = 2.3 at voxel level and a cluster level corrected for the whole brain at p < 0.05. The two black arrows indicate two foci of activity in dorsal premot... |
PMC1064074_F2_1497.jpg | What can you see in this picture? | Role of Na+–H+ exchanger (NHE)1 in serum deprivation-dependent rearrangement of the actin cytoskeleton. (a) To examine the role of NHE1 in serum deprivation-induced reorganization of the actin cytoskeleton underlying motility and invasive ability, MDA-MB-435 cell monolayers were left in fresh whole growth medium (nonde... |
PMC1064074_F2_1498.jpg | What is the core subject represented in this visual? | Role of Na+–H+ exchanger (NHE)1 in serum deprivation-dependent rearrangement of the actin cytoskeleton. (a) To examine the role of NHE1 in serum deprivation-induced reorganization of the actin cytoskeleton underlying motility and invasive ability, MDA-MB-435 cell monolayers were left in fresh whole growth medium (nonde... |
PMC1064077_F7_1501.jpg | What stands out most in this visual? | Solid carcinoma from a mouse transgenic for Hras: expression of α-smooth muscle actin in carcinomas is restricted to stromal myofibroblasts and vascular smooth muscle fibers. A similar observation was made for carcinomas arising in mice transgenic for Neu (Erbb2) and Notch 4 and in most mice transgenic for SV40-TAg (no... |
PMC1064094_F1_1511.jpg | Can you identify the primary element in this image? | Histological features of the carcinomatous breast (magnification × 100). Detailed histology of (a) is seen in (b–d). AS, anucleate squames; asterisks, interstitial lymphocytic infiltrates; G, galactophore; K, keratin; LS, lactiferous sinus; LD, lactiferous duct; SG, sebaceous gland (tangenial cut); SGD, sweat gland duc... |
PMC1064094_F1_1512.jpg | What is shown in this image? | Histological features of the carcinomatous breast (magnification × 100). Detailed histology of (a) is seen in (b–d). AS, anucleate squames; asterisks, interstitial lymphocytic infiltrates; G, galactophore; K, keratin; LS, lactiferous sinus; LD, lactiferous duct; SG, sebaceous gland (tangenial cut); SGD, sweat gland duc... |
PMC1064094_F1_1513.jpg | What's the most prominent thing you notice in this picture? | Histological features of the carcinomatous breast (magnification × 100). Detailed histology of (a) is seen in (b–d). AS, anucleate squames; asterisks, interstitial lymphocytic infiltrates; G, galactophore; K, keratin; LS, lactiferous sinus; LD, lactiferous duct; SG, sebaceous gland (tangenial cut); SGD, sweat gland duc... |
PMC1064094_F1_1514.jpg | What is the principal component of this image? | Histological features of the carcinomatous breast (magnification × 100). Detailed histology of (a) is seen in (b–d). AS, anucleate squames; asterisks, interstitial lymphocytic infiltrates; G, galactophore; K, keratin; LS, lactiferous sinus; LD, lactiferous duct; SG, sebaceous gland (tangenial cut); SGD, sweat gland duc... |
PMC1064094_F2_1505.jpg | What is the central feature of this picture? | Papillomavirus sequences detected by in situ hybridisation. (a) Case 10012, in the nipple epithelium (magnification × 40). (b) Case 10041, in the nipple epithelium (magnification × 40). (c) Case 10012, in tumour tissue (magnification × 100). (d) Case 10014, in tumour tissue (magnification × 100). |
PMC1064094_F2_1506.jpg | What does this image primarily show? | Papillomavirus sequences detected by in situ hybridisation. (a) Case 10012, in the nipple epithelium (magnification × 40). (b) Case 10041, in the nipple epithelium (magnification × 40). (c) Case 10012, in tumour tissue (magnification × 100). (d) Case 10014, in tumour tissue (magnification × 100). |
PMC1064094_F2_1503.jpg | Describe the main subject of this image. | Papillomavirus sequences detected by in situ hybridisation. (a) Case 10012, in the nipple epithelium (magnification × 40). (b) Case 10041, in the nipple epithelium (magnification × 40). (c) Case 10012, in tumour tissue (magnification × 100). (d) Case 10014, in tumour tissue (magnification × 100). |
PMC1064094_F2_1504.jpg | Describe the main subject of this image. | Papillomavirus sequences detected by in situ hybridisation. (a) Case 10012, in the nipple epithelium (magnification × 40). (b) Case 10041, in the nipple epithelium (magnification × 40). (c) Case 10012, in tumour tissue (magnification × 100). (d) Case 10014, in tumour tissue (magnification × 100). |
PMC1064097_F1_1508.jpg | What is the central feature of this picture? | A 3-cm infiltrating ductal carcinoma of the right breast. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 13 min and 55 min (bottom row, iii-iv). Focal radiotracer accumulation (arrowhead) in the upper breast hemisphere, corresponding to... |
PMC1064097_F1_1509.jpg | What is the main focus of this visual representation? | A 3-cm infiltrating ductal carcinoma of the right breast. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 13 min and 55 min (bottom row, iii-iv). Focal radiotracer accumulation (arrowhead) in the upper breast hemisphere, corresponding to... |
PMC1064097_F1_1510.jpg | What is being portrayed in this visual content? | A 3-cm infiltrating ductal carcinoma of the right breast. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 13 min and 55 min (bottom row, iii-iv). Focal radiotracer accumulation (arrowhead) in the upper breast hemisphere, corresponding to... |
PMC1064097_F1_1507.jpg | What key item or scene is captured in this photo? | A 3-cm infiltrating ductal carcinoma of the right breast. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 13 min and 55 min (bottom row, iii-iv). Focal radiotracer accumulation (arrowhead) in the upper breast hemisphere, corresponding to... |
PMC1064097_F2_1515.jpg | What does this image primarily show? | A 5-cm infiltrating ductal carcinoma, grade 2, with 9-cm, comedo-type, ductal carcinoma in situ of the right breast (patient 4). (a) Mammography, medio-lateral projection. Nodule with spiky margins (transparent arrow), close to the chest wall in the upper breast hemisphere. (b) Scintimammography, right lateral projecti... |
PMC1064097_F2_1518.jpg | Can you identify the primary element in this image? | A 5-cm infiltrating ductal carcinoma, grade 2, with 9-cm, comedo-type, ductal carcinoma in situ of the right breast (patient 4). (a) Mammography, medio-lateral projection. Nodule with spiky margins (transparent arrow), close to the chest wall in the upper breast hemisphere. (b) Scintimammography, right lateral projecti... |
PMC1064097_F2_1516.jpg | What is the principal component of this image? | A 5-cm infiltrating ductal carcinoma, grade 2, with 9-cm, comedo-type, ductal carcinoma in situ of the right breast (patient 4). (a) Mammography, medio-lateral projection. Nodule with spiky margins (transparent arrow), close to the chest wall in the upper breast hemisphere. (b) Scintimammography, right lateral projecti... |
PMC1064097_F2_1519.jpg | What is being portrayed in this visual content? | A 5-cm infiltrating ductal carcinoma, grade 2, with 9-cm, comedo-type, ductal carcinoma in situ of the right breast (patient 4). (a) Mammography, medio-lateral projection. Nodule with spiky margins (transparent arrow), close to the chest wall in the upper breast hemisphere. (b) Scintimammography, right lateral projecti... |
PMC1064097_F3_1526.jpg | What object or scene is depicted here? | A 6-cm infiltrating ductal carcinoma, grade 2, with coexistent 5-cm ductal carcinoma in situ, comedo type, of the left breast (patient 1). (a) Mammography, medio-lateral projection. Multinodular opacity with abnormal radiating spicules and clustered microcalcifications (transparent arrow) behind the nipple. (b) Scintim... |
PMC1064097_F3_1528.jpg | What is the principal component of this image? | A 6-cm infiltrating ductal carcinoma, grade 2, with coexistent 5-cm ductal carcinoma in situ, comedo type, of the left breast (patient 1). (a) Mammography, medio-lateral projection. Multinodular opacity with abnormal radiating spicules and clustered microcalcifications (transparent arrow) behind the nipple. (b) Scintim... |
PMC1064097_F4_1521.jpg | What is the focal point of this photograph? | A 4.5-cm ductal carcinoma in situ of the left breast, comedo, solid and cribriform type (patient 18). (a) Mammography, medio-lateral projection. Microcalcifications (transparent arrow) behind the nipple. (b) Scintimammography, left lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (i-ii). Diffuse semi-lunar accumu... |
PMC1064097_F4_1520.jpg | Describe the main subject of this image. | A 4.5-cm ductal carcinoma in situ of the left breast, comedo, solid and cribriform type (patient 18). (a) Mammography, medio-lateral projection. Microcalcifications (transparent arrow) behind the nipple. (b) Scintimammography, left lateral projection: 99mTc-(V)DMSA at 10 min and 60 min (i-ii). Diffuse semi-lunar accumu... |
PMC1064097_F5_1537.jpg | What's the most prominent thing you notice in this picture? | A 4-cm infiltrating lobular carcinoma, grade 3, associated with 6-cm lobular carcinoma in situ (LCIS) of the left breast in a 65-year-old woman (patient 20). (a) Mammography, cranio-caudal projection. Nodular opacity (asterisk) in the inner hemisphere of the breast. (b) Scintimammography, left lateral projection: 99mTc... |
PMC1064097_F6_1524.jpg | What is the focal point of this photograph? | Atypical epithelial hyperplasia of the right breast in a 41-year-old woman. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 15 min and 75 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 10 min and 70 min (bottom row, iii-iv). Increased diffuse homogeneous 99mTc-(V)DMSA uptake (arrow) at early and l... |
PMC1064097_F6_1523.jpg | What's the most prominent thing you notice in this picture? | Atypical epithelial hyperplasia of the right breast in a 41-year-old woman. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 15 min and 75 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 10 min and 70 min (bottom row, iii-iv). Increased diffuse homogeneous 99mTc-(V)DMSA uptake (arrow) at early and l... |
PMC1064097_F6_1522.jpg | Describe the main subject of this image. | Atypical epithelial hyperplasia of the right breast in a 41-year-old woman. Scintimammography, right lateral projection: 99mTc-(V)DMSA at 15 min and 75 min (upper row, i-ii); 99mTc-Sestamibi (99mTc-MIBI) at 10 min and 70 min (bottom row, iii-iv). Increased diffuse homogeneous 99mTc-(V)DMSA uptake (arrow) at early and l... |
PMC1064097_F7_1536.jpg | What is the dominant medical problem in this image? | Ductal carcinoma in situ (DCIS), comedo, solid and cribriform type (patient 18). (a) Tumor section (hematoxylin & eosin, × 25). Regions of DCIS (arrowheads), within normal breast tissue (asterisk). (b) In vitro 99mTc-(V)DMSA autoradiogram of the same section (× 25). Distribution of the radioactivity in the same tumor s... |
PMC1064097_F7_1534.jpg | What object or scene is depicted here? | Ductal carcinoma in situ (DCIS), comedo, solid and cribriform type (patient 18). (a) Tumor section (hematoxylin & eosin, × 25). Regions of DCIS (arrowheads), within normal breast tissue (asterisk). (b) In vitro 99mTc-(V)DMSA autoradiogram of the same section (× 25). Distribution of the radioactivity in the same tumor s... |
PMC1064098_F1_1533.jpg | Can you identify the primary element in this image? | MCF10A cells and MCF10AT cells in monoculture and in co-culture with fibroblasts. (a), (b) MCF10A cells and (c), (d) MCF10AT cells in monoculture initially form a lattice/scaffold arrangement (a, c). After several days of culture, spheroidal structures become more prominent (b, d). (e) MCF10AT cells in co-culture with ... |
PMC1064098_F1_1529.jpg | Describe the main subject of this image. | MCF10A cells and MCF10AT cells in monoculture and in co-culture with fibroblasts. (a), (b) MCF10A cells and (c), (d) MCF10AT cells in monoculture initially form a lattice/scaffold arrangement (a, c). After several days of culture, spheroidal structures become more prominent (b, d). (e) MCF10AT cells in co-culture with ... |
PMC1064098_F1_1530.jpg | What is the main focus of this visual representation? | MCF10A cells and MCF10AT cells in monoculture and in co-culture with fibroblasts. (a), (b) MCF10A cells and (c), (d) MCF10AT cells in monoculture initially form a lattice/scaffold arrangement (a, c). After several days of culture, spheroidal structures become more prominent (b, d). (e) MCF10AT cells in co-culture with ... |
PMC1064098_F1_1531.jpg | What stands out most in this visual? | MCF10A cells and MCF10AT cells in monoculture and in co-culture with fibroblasts. (a), (b) MCF10A cells and (c), (d) MCF10AT cells in monoculture initially form a lattice/scaffold arrangement (a, c). After several days of culture, spheroidal structures become more prominent (b, d). (e) MCF10AT cells in co-culture with ... |
PMC1064098_F2_1540.jpg | What does this image primarily show? | H&E-stained histologic sections of MCF10A cell and MCF10AT cell monocultures and co-cultures with fibroblasts. (a) MCF10A cells form small spheroids. (b) MCF10A cells in co-culture with fibroblasts are located adjacent to the fibroblast aggregate (F) and maintain smaller spheroids. (c) In monoculture, MCF10AT cells for... |
PMC1064098_F2_1542.jpg | What is the principal component of this image? | H&E-stained histologic sections of MCF10A cell and MCF10AT cell monocultures and co-cultures with fibroblasts. (a) MCF10A cells form small spheroids. (b) MCF10A cells in co-culture with fibroblasts are located adjacent to the fibroblast aggregate (F) and maintain smaller spheroids. (c) In monoculture, MCF10AT cells for... |
PMC1064098_F2_1543.jpg | What is the dominant medical problem in this image? | H&E-stained histologic sections of MCF10A cell and MCF10AT cell monocultures and co-cultures with fibroblasts. (a) MCF10A cells form small spheroids. (b) MCF10A cells in co-culture with fibroblasts are located adjacent to the fibroblast aggregate (F) and maintain smaller spheroids. (c) In monoculture, MCF10AT cells for... |
PMC1064098_F3_1546.jpg | What is the core subject represented in this visual? | Distribution and relative quantities of fibroblasts and epithelial cells in a normal terminal duct-lobular unit, hyperplasia and ductal carcinoma in situ (DCIS). (a) A terminal duct-lobular unit with epithelial cells (arrowheads) arranged in acini and intralobular terminal ducts separated by stroma-containing fibroblas... |
PMC1064098_F3_1545.jpg | What can you see in this picture? | Distribution and relative quantities of fibroblasts and epithelial cells in a normal terminal duct-lobular unit, hyperplasia and ductal carcinoma in situ (DCIS). (a) A terminal duct-lobular unit with epithelial cells (arrowheads) arranged in acini and intralobular terminal ducts separated by stroma-containing fibroblas... |
PMC1064114_F1_1549.jpg | What is the focal point of this photograph? | Histopathology of tumours in (BALB/cHeA × MSM/Ms)F1 mice with genotypes p53+/- Atm+/-, p53+/- Atm+/+ or p53+/+ Atm+/-. (a, b) Spontaneously developing mammary adenocarcinoma from p53+/- Atm+/- mouse. (c, d) Mammary adenocarcinoma from X-irradiated p53+/- Atm+/- mouse. (e, f) Mammary adenocarcinoma from X-irradiated p53... |
PMC1064114_F1_1552.jpg | What key item or scene is captured in this photo? | Histopathology of tumours in (BALB/cHeA × MSM/Ms)F1 mice with genotypes p53+/- Atm+/-, p53+/- Atm+/+ or p53+/+ Atm+/-. (a, b) Spontaneously developing mammary adenocarcinoma from p53+/- Atm+/- mouse. (c, d) Mammary adenocarcinoma from X-irradiated p53+/- Atm+/- mouse. (e, f) Mammary adenocarcinoma from X-irradiated p53... |
PMC1064114_F1_1547.jpg | What object or scene is depicted here? | Histopathology of tumours in (BALB/cHeA × MSM/Ms)F1 mice with genotypes p53+/- Atm+/-, p53+/- Atm+/+ or p53+/+ Atm+/-. (a, b) Spontaneously developing mammary adenocarcinoma from p53+/- Atm+/- mouse. (c, d) Mammary adenocarcinoma from X-irradiated p53+/- Atm+/- mouse. (e, f) Mammary adenocarcinoma from X-irradiated p53... |
PMC1064114_F1_1550.jpg | What is the core subject represented in this visual? | Histopathology of tumours in (BALB/cHeA × MSM/Ms)F1 mice with genotypes p53+/- Atm+/-, p53+/- Atm+/+ or p53+/+ Atm+/-. (a, b) Spontaneously developing mammary adenocarcinoma from p53+/- Atm+/- mouse. (c, d) Mammary adenocarcinoma from X-irradiated p53+/- Atm+/- mouse. (e, f) Mammary adenocarcinoma from X-irradiated p53... |
PMC1064114_F1_1551.jpg | What is shown in this image? | Histopathology of tumours in (BALB/cHeA × MSM/Ms)F1 mice with genotypes p53+/- Atm+/-, p53+/- Atm+/+ or p53+/+ Atm+/-. (a, b) Spontaneously developing mammary adenocarcinoma from p53+/- Atm+/- mouse. (c, d) Mammary adenocarcinoma from X-irradiated p53+/- Atm+/- mouse. (e, f) Mammary adenocarcinoma from X-irradiated p53... |
PMC1064136_F2_1566.jpg | What is the main focus of this visual representation? | Claudin (CLDN)1 positivity in normal breast epithelium, tumour cell membranes and intraductal papilloma. (a) CLDN1 positivity in normal breast epithelium. Normal epithelial cells exhibit intensive CLDN1 positivity in the cell membrane. Image obtained using laser scanning confocal microscopy (MRC 1024; Bio-Rad). Primary... |
PMC1064136_F2_1565.jpg | What is the focal point of this photograph? | Claudin (CLDN)1 positivity in normal breast epithelium, tumour cell membranes and intraductal papilloma. (a) CLDN1 positivity in normal breast epithelium. Normal epithelial cells exhibit intensive CLDN1 positivity in the cell membrane. Image obtained using laser scanning confocal microscopy (MRC 1024; Bio-Rad). Primary... |
PMC1064136_F3_1561.jpg | What is the core subject represented in this visual? | Claudin (CLDN)3 positivity in benign breast tissue and invasive ductal breast carcinoma. (a) CLDN3 positivity in benign breast tissue. Regular immunohistochemical reaction of benign breast epithelial cells using polyclonal CLDN3 antibody. Continous membrane staining characterizes most of the luminal epithelial cells. S... |
PMC1064136_F3_1559.jpg | What's the most prominent thing you notice in this picture? | Claudin (CLDN)3 positivity in benign breast tissue and invasive ductal breast carcinoma. (a) CLDN3 positivity in benign breast tissue. Regular immunohistochemical reaction of benign breast epithelial cells using polyclonal CLDN3 antibody. Continous membrane staining characterizes most of the luminal epithelial cells. S... |
PMC1064136_F3_1560.jpg | What is being portrayed in this visual content? | Claudin (CLDN)3 positivity in benign breast tissue and invasive ductal breast carcinoma. (a) CLDN3 positivity in benign breast tissue. Regular immunohistochemical reaction of benign breast epithelial cells using polyclonal CLDN3 antibody. Continous membrane staining characterizes most of the luminal epithelial cells. S... |
PMC1064136_F3_1562.jpg | What does this image primarily show? | Claudin (CLDN)3 positivity in benign breast tissue and invasive ductal breast carcinoma. (a) CLDN3 positivity in benign breast tissue. Regular immunohistochemical reaction of benign breast epithelial cells using polyclonal CLDN3 antibody. Continous membrane staining characterizes most of the luminal epithelial cells. S... |
PMC1064136_F4_1558.jpg | What is the principal component of this image? | Claudin (CLDN)4 expression in benign breast epithelium, in invasive ductal carcinomas and in intraductal papilloma. (a) Intense CLDN4 positivity in benign breast epithelium. Shown is the immunohistochemical reaction of benign breast using monoclonal CLDN4 antibody (Zymed). Strong positivity is seen in epithelial cell m... |
PMC1064136_F4_1557.jpg | What's the most prominent thing you notice in this picture? | Claudin (CLDN)4 expression in benign breast epithelium, in invasive ductal carcinomas and in intraductal papilloma. (a) Intense CLDN4 positivity in benign breast epithelium. Shown is the immunohistochemical reaction of benign breast using monoclonal CLDN4 antibody (Zymed). Strong positivity is seen in epithelial cell m... |
PMC1064136_F4_1556.jpg | What is the main focus of this visual representation? | Claudin (CLDN)4 expression in benign breast epithelium, in invasive ductal carcinomas and in intraductal papilloma. (a) Intense CLDN4 positivity in benign breast epithelium. Shown is the immunohistochemical reaction of benign breast using monoclonal CLDN4 antibody (Zymed). Strong positivity is seen in epithelial cell m... |
PMC1064138_F3_1569.jpg | What is being portrayed in this visual content? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064138_F3_1571.jpg | What is the principal component of this image? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064138_F3_1575.jpg | What key item or scene is captured in this photo? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064138_F3_1570.jpg | What's the most prominent thing you notice in this picture? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064138_F3_1572.jpg | What is the main focus of this visual representation? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064138_F3_1573.jpg | What is the principal component of this image? | Immunolocalization of claudin 7 (Cy3, red) in cultured mammary epithelial cells, epididymis, lung, kidney, and liver. ZO-1 is stained with fluorescein isothiocyanate to demonstrate location of the tight junctions. (a) Eph4 cells. Claudin 7 is found with a patchy distribution at the tight junctions with ZO1. Vesicular s... |
PMC1064849_pbio-0030087-g004_1578.jpg | What key item or scene is captured in this photo? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064849_pbio-0030087-g004_1582.jpg | What can you see in this picture? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064849_pbio-0030087-g004_1583.jpg | What is the dominant medical problem in this image? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064849_pbio-0030087-g004_1577.jpg | What stands out most in this visual? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064849_pbio-0030087-g004_1579.jpg | What stands out most in this visual? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064849_pbio-0030087-g004_1580.jpg | What is the dominant medical problem in this image? | Transmission EMs Show the Post-Replating Progression of CPS Cells(A) Round, day 3 cells contain disordered myosin filaments. Some of these cells beat while still floating (see Video S1) and typically have APs as shown in Figure 6A.(B) Upper box is a blowup taken from lower panel, showing myosin filaments of characteris... |
PMC1064851_pbio-0030093-g001_1591.jpg | What is the principal component of this image? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g001_1586.jpg | What is being portrayed in this visual content? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g001_1590.jpg | What is the dominant medical problem in this image? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g001_1584.jpg | What is shown in this image? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g001_1588.jpg | What is the main focus of this visual representation? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g001_1589.jpg | What is the core subject represented in this visual? | Expression of eve
(A–D) Embryos of four Drosophila species at early cellular blastoderm stage. EVE stained with immunoperoxidase DAB reaction enhanced by nickel.(E–H) Df(eve) D. melanogaster embryos with two copies of transgenes containing eve S2E from four species fused to D. melanogaster eve coding region (−0.9 to +1... |
PMC1064851_pbio-0030093-g003_1595.jpg | What is shown in this image? | Developmental Series of EVE Abundance(A–E) Immunofluorescence labeling of time-staged early EVEΔS2E homozygous embryos. This developmental sequence, which corresponds roughly from the initialization of cellularization (A) to its completion (E), takes approximately 45 min at 25 oC in wild-type flies [41].(F) Expression ... |
PMC1064851_pbio-0030093-g003_1593.jpg | What object or scene is depicted here? | Developmental Series of EVE Abundance(A–E) Immunofluorescence labeling of time-staged early EVEΔS2E homozygous embryos. This developmental sequence, which corresponds roughly from the initialization of cellularization (A) to its completion (E), takes approximately 45 min at 25 oC in wild-type flies [41].(F) Expression ... |
PMC1064851_pbio-0030093-g003_1598.jpg | What is the dominant medical problem in this image? | Developmental Series of EVE Abundance(A–E) Immunofluorescence labeling of time-staged early EVEΔS2E homozygous embryos. This developmental sequence, which corresponds roughly from the initialization of cellularization (A) to its completion (E), takes approximately 45 min at 25 oC in wild-type flies [41].(F) Expression ... |
PMC1064851_pbio-0030093-g003_1597.jpg | What can you see in this picture? | Developmental Series of EVE Abundance(A–E) Immunofluorescence labeling of time-staged early EVEΔS2E homozygous embryos. This developmental sequence, which corresponds roughly from the initialization of cellularization (A) to its completion (E), takes approximately 45 min at 25 oC in wild-type flies [41].(F) Expression ... |
PMC1064897_F2_1600.jpg | Can you identify the primary element in this image? | Histological assessment of synovial inflammation and joint destruction. No signs of arthritis are seen in the tarsal joints of wild-type (wt) and JNK1 (c-Jun N-terminal kinase 1) knockout (JNK1-/-) mice, whereas severe inflammation (I) and numerous erosions (E) are observed in human TNF transgenic (hTNFtg) and intercro... |
PMC1064897_F2_1601.jpg | Describe the main subject of this image. | Histological assessment of synovial inflammation and joint destruction. No signs of arthritis are seen in the tarsal joints of wild-type (wt) and JNK1 (c-Jun N-terminal kinase 1) knockout (JNK1-/-) mice, whereas severe inflammation (I) and numerous erosions (E) are observed in human TNF transgenic (hTNFtg) and intercro... |
PMC1064897_F2_1602.jpg | Describe the main subject of this image. | Histological assessment of synovial inflammation and joint destruction. No signs of arthritis are seen in the tarsal joints of wild-type (wt) and JNK1 (c-Jun N-terminal kinase 1) knockout (JNK1-/-) mice, whereas severe inflammation (I) and numerous erosions (E) are observed in human TNF transgenic (hTNFtg) and intercro... |
PMC1064897_F4_1603.jpg | What stands out most in this visual? | Synovial osteoclasts in human tumour necrosis factor transgenic (hTNFtg) and JNK1-/-hTNFtg mice. As demonstrated by staining with tartrate-resistant acid phosphatase (a), there are abundant osteoclasts (OC) at the site of erosions in hTNFtg and intercrossed (JNK1-/-hTNFtg) mice, which all developed arthritis (magnifica... |
PMC1064897_F5_1608.jpg | What is the main focus of this visual representation? | Evaluation of proteoglycan loss in human tumour necrosis factor transgenic (hTNFtg) and JNK1-/-hTNFtg mice. As shown by toluidine blue staining (a), arthritis leads to loss of proteoglycan (arrows) in the cartilage of hTNFtg and intercrossed JNK1-/-hTNFtg mice (magnification 100×). The area of early cartilage damage (b... |
PMC1064897_F5_1610.jpg | What object or scene is depicted here? | Evaluation of proteoglycan loss in human tumour necrosis factor transgenic (hTNFtg) and JNK1-/-hTNFtg mice. As shown by toluidine blue staining (a), arthritis leads to loss of proteoglycan (arrows) in the cartilage of hTNFtg and intercrossed JNK1-/-hTNFtg mice (magnification 100×). The area of early cartilage damage (b... |
PMC1064897_F5_1612.jpg | What is the dominant medical problem in this image? | Evaluation of proteoglycan loss in human tumour necrosis factor transgenic (hTNFtg) and JNK1-/-hTNFtg mice. As shown by toluidine blue staining (a), arthritis leads to loss of proteoglycan (arrows) in the cartilage of hTNFtg and intercrossed JNK1-/-hTNFtg mice (magnification 100×). The area of early cartilage damage (b... |
PMC1065025_F1_1607.jpg | What is the focal point of this photograph? | The girl: cranial computed tomography, done 7 hours after admission, showing cerebral oedema. |
PMC1065025_F2_1613.jpg | What is the central feature of this picture? | The girl: computed tomography of the thorax, done shortly after admission to hospital, showing infiltrations in the basal dorsal thorax following aspiration. |
PMC1065049_F3_1616.jpg | What is shown in this image? | Cross-section of a nerve biopsy specimen from patient 4 exhibiting severe axonal neuropathy. There is loss of myelinated nerve fibres. Some large myelinated fibres show degenerating myelin ovoids. Secondary demyelination is seen in rare nerve fibres. Clusters of Schwann cells without nerve fibres are increased. Resin s... |
PMC1065316_F4_1622.jpg | What is the dominant medical problem in this image? | Immunohistochemistry of CXCR5 in the intima and postcapillary venules in rheumatoid arthritis synovia. (a) CD68+ cells in the intima. (b) Serial section to (a) stained for CXCR5. Note the colocalization of CXCR5 and CD68 to the same group of cells. (c) and (d) Sections from the same region as (a) and (b), treated with ... |
PMC1065316_F4_1619.jpg | What is the main focus of this visual representation? | Immunohistochemistry of CXCR5 in the intima and postcapillary venules in rheumatoid arthritis synovia. (a) CD68+ cells in the intima. (b) Serial section to (a) stained for CXCR5. Note the colocalization of CXCR5 and CD68 to the same group of cells. (c) and (d) Sections from the same region as (a) and (b), treated with ... |
PMC1065316_F4_1618.jpg | What is being portrayed in this visual content? | Immunohistochemistry of CXCR5 in the intima and postcapillary venules in rheumatoid arthritis synovia. (a) CD68+ cells in the intima. (b) Serial section to (a) stained for CXCR5. Note the colocalization of CXCR5 and CD68 to the same group of cells. (c) and (d) Sections from the same region as (a) and (b), treated with ... |
PMC1065316_F4_1620.jpg | What is being portrayed in this visual content? | Immunohistochemistry of CXCR5 in the intima and postcapillary venules in rheumatoid arthritis synovia. (a) CD68+ cells in the intima. (b) Serial section to (a) stained for CXCR5. Note the colocalization of CXCR5 and CD68 to the same group of cells. (c) and (d) Sections from the same region as (a) and (b), treated with ... |
PMC1065316_F4_1621.jpg | What key item or scene is captured in this photo? | Immunohistochemistry of CXCR5 in the intima and postcapillary venules in rheumatoid arthritis synovia. (a) CD68+ cells in the intima. (b) Serial section to (a) stained for CXCR5. Note the colocalization of CXCR5 and CD68 to the same group of cells. (c) and (d) Sections from the same region as (a) and (b), treated with ... |
PMC1065316_F5_1623.jpg | What can you see in this picture? | Immunohistochemistry of CXCR5 in non-rheumatoid arthritis synovia. (a) CD68 staining in the intimal layer. (b) Serial section to (a) treated with anti-CXCR5, showing that CXCR5+ cells in the intimal layer included those also positive for CD68. (c) and (d) Sections from the same region as (a) and (b), treated with isoty... |
PMC1065316_F5_1626.jpg | What can you see in this picture? | Immunohistochemistry of CXCR5 in non-rheumatoid arthritis synovia. (a) CD68 staining in the intimal layer. (b) Serial section to (a) treated with anti-CXCR5, showing that CXCR5+ cells in the intimal layer included those also positive for CD68. (c) and (d) Sections from the same region as (a) and (b), treated with isoty... |
PMC1065316_F5_1625.jpg | What can you see in this picture? | Immunohistochemistry of CXCR5 in non-rheumatoid arthritis synovia. (a) CD68 staining in the intimal layer. (b) Serial section to (a) treated with anti-CXCR5, showing that CXCR5+ cells in the intimal layer included those also positive for CD68. (c) and (d) Sections from the same region as (a) and (b), treated with isoty... |
PMC1065316_F5_1628.jpg | What key item or scene is captured in this photo? | Immunohistochemistry of CXCR5 in non-rheumatoid arthritis synovia. (a) CD68 staining in the intimal layer. (b) Serial section to (a) treated with anti-CXCR5, showing that CXCR5+ cells in the intimal layer included those also positive for CD68. (c) and (d) Sections from the same region as (a) and (b), treated with isoty... |
PMC1065321_F2_1638.jpg | What does this image primarily show? | In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; sof... |
PMC1065321_F2_1637.jpg | What can you see in this picture? | In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; sof... |
PMC1065321_F2_1640.jpg | What does this image primarily show? | In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; sof... |
PMC1065321_F2_1642.jpg | What is the focal point of this photograph? | In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; sof... |
PMC1065321_F2_1641.jpg | Can you identify the primary element in this image? | In vivo near-infrared fluorescent (NIRF) imaging of inflammatory joints in the lipopolysaccharide (LPS) induction model. The NIR2-folate probe was intravenously injected 2 days after LPS intra-articular injection. (a) White-light images obtained 48 hours after intra-articular LPS injection at the right ankle joint; sof... |
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