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PMC2254193_pone-0001741-g005_18149.jpg | What is the central feature of this picture? | S100A7 downregulation decreases osteolytic lesions in vivo.
Cells were directly introduced into the tibias of 4 week-old mice, as described in Materials and Methods. Micro-CT scanning of live mice was done using a GE eXplore Micro-CT scanner (GE Healthcare Ltd, UK) at 93 µm resolution, 6 weeks after injection. The tibi... |
PMC2254392_F5_18155.jpg | What object or scene is depicted here? | Images from confocal microscopy. Three views of a CF11 fibre are shown, as schematized in the right insertion of figure c. The insertions d, e and f correspond to the pixels intensity (256 grey levels) obtained at the position indicated by the line (white circle), at different depths. The adsorption conditions were 20 ... |
PMC2254427_F1_18156.jpg | What does this image primarily show? | CT scan demonstrating a 12 × 13 × 10 cm (1560 cm3) mass in the pelvis. There is significant bilateral compression of the external iliac vessels and rectum. |
PMC2254427_F2_18157.jpg | What is being portrayed in this visual content? | Bilateral mild to moderate hydroureteronephrosis was noted, and the left kidney appeared markedly atrophic. |
PMC2254588_F1_18182.jpg | What is the main focus of this visual representation? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18181.jpg | What can you see in this picture? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18171.jpg | What is being portrayed in this visual content? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18174.jpg | What is the dominant medical problem in this image? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18184.jpg | What is the dominant medical problem in this image? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18177.jpg | What can you see in this picture? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18183.jpg | What is the central feature of this picture? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18172.jpg | What is being portrayed in this visual content? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18185.jpg | What is the principal component of this image? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18176.jpg | Can you identify the primary element in this image? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F1_18173.jpg | What is the central feature of this picture? | Chronic maternal TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos from control and chronically exposed (50 ng/kg/wk TCDD) female rats were processed for visualization of microtubules, f-actin and DNA by confocal microscopy. (A... |
PMC2254588_F3_18165.jpg | Can you identify the primary element in this image? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18166.jpg | What is the core subject represented in this visual? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18159.jpg | Describe the main subject of this image. | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18168.jpg | What stands out most in this visual? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18169.jpg | What is shown in this image? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18163.jpg | What is the principal component of this image? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18164.jpg | What is the core subject represented in this visual? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18160.jpg | What's the most prominent thing you notice in this picture? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254588_F3_18170.jpg | What is the core subject represented in this visual? | Acute maternal periconceptional TCDD exposure induces nuclear and cytoskeletal defects in compaction stage pre-implantation embryos. Compaction stage pre-implantation embryos collected from control and acutely exposed (50 ng/kg and 1 μg/kg TCDD) female rats and processed for visualization of microtubules, f-actin and D... |
PMC2254608_F5_18192.jpg | What is the principal component of this image? | Comparison of GFP, immunostaining and FISH signals without RNAse digestion, allowing for detection of RNA from the transgene arrays by the FISH probe. For panel labeling see Figure 2. Projections of deconvolved images are shown. Note the larger volume of FISH signals compared to other signals. In this experiment, due t... |
PMC2254608_F5_18193.jpg | Describe the main subject of this image. | Comparison of GFP, immunostaining and FISH signals without RNAse digestion, allowing for detection of RNA from the transgene arrays by the FISH probe. For panel labeling see Figure 2. Projections of deconvolved images are shown. Note the larger volume of FISH signals compared to other signals. In this experiment, due t... |
PMC2254608_F5_18194.jpg | What is the principal component of this image? | Comparison of GFP, immunostaining and FISH signals without RNAse digestion, allowing for detection of RNA from the transgene arrays by the FISH probe. For panel labeling see Figure 2. Projections of deconvolved images are shown. Note the larger volume of FISH signals compared to other signals. In this experiment, due t... |
PMC2254608_F5_18197.jpg | What does this image primarily show? | Comparison of GFP, immunostaining and FISH signals without RNAse digestion, allowing for detection of RNA from the transgene arrays by the FISH probe. For panel labeling see Figure 2. Projections of deconvolved images are shown. Note the larger volume of FISH signals compared to other signals. In this experiment, due t... |
PMC2254608_F5_18188.jpg | Describe the main subject of this image. | Comparison of GFP, immunostaining and FISH signals without RNAse digestion, allowing for detection of RNA from the transgene arrays by the FISH probe. For panel labeling see Figure 2. Projections of deconvolved images are shown. Note the larger volume of FISH signals compared to other signals. In this experiment, due t... |
PMC2254616_F1_18200.jpg | What object or scene is depicted here? | Overview of musculature of Ophryotrocha diadema. Scale bars = 50 μm, anterior is to the left. A. Dorsal view, phalloidin staining. The most prominent muscles in the prostomium are the ventral diagonal muscles (dVLM). Two transverse muscles are present in the prostomium: PStm2 crosses the dVLM dorsally, whereas PStm1 li... |
PMC2254616_F1_18204.jpg | What is the focal point of this photograph? | Overview of musculature of Ophryotrocha diadema. Scale bars = 50 μm, anterior is to the left. A. Dorsal view, phalloidin staining. The most prominent muscles in the prostomium are the ventral diagonal muscles (dVLM). Two transverse muscles are present in the prostomium: PStm2 crosses the dVLM dorsally, whereas PStm1 li... |
PMC2254616_F1_18201.jpg | What is the core subject represented in this visual? | Overview of musculature of Ophryotrocha diadema. Scale bars = 50 μm, anterior is to the left. A. Dorsal view, phalloidin staining. The most prominent muscles in the prostomium are the ventral diagonal muscles (dVLM). Two transverse muscles are present in the prostomium: PStm2 crosses the dVLM dorsally, whereas PStm1 li... |
PMC2254616_F1_18205.jpg | What is the main focus of this visual representation? | Overview of musculature of Ophryotrocha diadema. Scale bars = 50 μm, anterior is to the left. A. Dorsal view, phalloidin staining. The most prominent muscles in the prostomium are the ventral diagonal muscles (dVLM). Two transverse muscles are present in the prostomium: PStm2 crosses the dVLM dorsally, whereas PStm1 li... |
PMC2254624_F1_18207.jpg | What can you see in this picture? | Thyroid metastases due to renal cell carcinoma. Contrast-enhanced computed tomography scan: (A, B, C) axial images and (D) volume-rendered reconstructed image; the right lobe of the thyroid gland shows a non-homogeneous and irregular mass with tracheal involvement. The mass extends into the fatty plane in proximity to ... |
PMC2254624_F1_18208.jpg | Can you identify the primary element in this image? | Thyroid metastases due to renal cell carcinoma. Contrast-enhanced computed tomography scan: (A, B, C) axial images and (D) volume-rendered reconstructed image; the right lobe of the thyroid gland shows a non-homogeneous and irregular mass with tracheal involvement. The mass extends into the fatty plane in proximity to ... |
PMC2254628_F2_18215.jpg | What can you see in this picture? | Immunohistochemical localization of ERα in hpg mice. Examples of immunohistochemical localization of ERα in the pituitary gland (upper panels) or testis of hypogonadal mice (hpg, left panels) or age-matched wild-type mice (+/+, right panels). Note that many anterior pituitary cells express nuclear ERα immunoreactivity ... |
PMC2254628_F2_18214.jpg | What can you see in this picture? | Immunohistochemical localization of ERα in hpg mice. Examples of immunohistochemical localization of ERα in the pituitary gland (upper panels) or testis of hypogonadal mice (hpg, left panels) or age-matched wild-type mice (+/+, right panels). Note that many anterior pituitary cells express nuclear ERα immunoreactivity ... |
PMC2254628_F2_18211.jpg | What does this image primarily show? | Immunohistochemical localization of ERα in hpg mice. Examples of immunohistochemical localization of ERα in the pituitary gland (upper panels) or testis of hypogonadal mice (hpg, left panels) or age-matched wild-type mice (+/+, right panels). Note that many anterior pituitary cells express nuclear ERα immunoreactivity ... |
PMC2254628_F2_18212.jpg | What is the dominant medical problem in this image? | Immunohistochemical localization of ERα in hpg mice. Examples of immunohistochemical localization of ERα in the pituitary gland (upper panels) or testis of hypogonadal mice (hpg, left panels) or age-matched wild-type mice (+/+, right panels). Note that many anterior pituitary cells express nuclear ERα immunoreactivity ... |
PMC2254629_F11_18217.jpg | What is the principal component of this image? | Immunofluorescence confocal microscopy: (a(i-ii)) ARHGDIA and (c) MSN and (d) p-MSN confocal microscopy immunolocalisation in human primary myometrial smooth muscle cells. A FITC negative control is presented (b) and the original magnification was ×40. |
PMC2254629_F11_18221.jpg | What can you see in this picture? | Immunofluorescence confocal microscopy: (a(i-ii)) ARHGDIA and (c) MSN and (d) p-MSN confocal microscopy immunolocalisation in human primary myometrial smooth muscle cells. A FITC negative control is presented (b) and the original magnification was ×40. |
PMC2254629_F11_18219.jpg | What is the principal component of this image? | Immunofluorescence confocal microscopy: (a(i-ii)) ARHGDIA and (c) MSN and (d) p-MSN confocal microscopy immunolocalisation in human primary myometrial smooth muscle cells. A FITC negative control is presented (b) and the original magnification was ×40. |
PMC2254629_F11_18220.jpg | What is shown in this image? | Immunofluorescence confocal microscopy: (a(i-ii)) ARHGDIA and (c) MSN and (d) p-MSN confocal microscopy immunolocalisation in human primary myometrial smooth muscle cells. A FITC negative control is presented (b) and the original magnification was ×40. |
PMC2254637_F5_18226.jpg | What is the dominant medical problem in this image? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18222.jpg | What does this image primarily show? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18227.jpg | What is the principal component of this image? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18225.jpg | What is the dominant medical problem in this image? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18223.jpg | What's the most prominent thing you notice in this picture? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18229.jpg | What is the main focus of this visual representation? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18228.jpg | Can you identify the primary element in this image? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F5_18224.jpg | What key item or scene is captured in this photo? | FGF-2 and GFG protein expression in rat tissues. Representative immunohistochemical staining of FGF-2 (panels a-d) and GFG (panels e-h) in rat liver (upper four panels) and kidney (lower four panels). FGF-2 immunoreactivity in liver was exclusively cytoplasmic (a, ×400; b, ×400 zoom). In contrast, GFG protein expressio... |
PMC2254637_F7_18236.jpg | What's the most prominent thing you notice in this picture? | Deletion analysis of rat GFG mitochondrial targeting. (A) Schematic representation of GFG:GFP fusion proteins. The grey, black and hatched boxes represent the GFP, nudix and mitochondrial targeting signal peptide (MTS) domains, respectively. rGFGΔ2 indicates the rGFGΔ2 isoform in which amino acids (aa) 77–145 encoded b... |
PMC2254637_F7_18233.jpg | What is shown in this image? | Deletion analysis of rat GFG mitochondrial targeting. (A) Schematic representation of GFG:GFP fusion proteins. The grey, black and hatched boxes represent the GFP, nudix and mitochondrial targeting signal peptide (MTS) domains, respectively. rGFGΔ2 indicates the rGFGΔ2 isoform in which amino acids (aa) 77–145 encoded b... |
PMC2254637_F7_18234.jpg | What is shown in this image? | Deletion analysis of rat GFG mitochondrial targeting. (A) Schematic representation of GFG:GFP fusion proteins. The grey, black and hatched boxes represent the GFP, nudix and mitochondrial targeting signal peptide (MTS) domains, respectively. rGFGΔ2 indicates the rGFGΔ2 isoform in which amino acids (aa) 77–145 encoded b... |
PMC2254637_F7_18238.jpg | Can you identify the primary element in this image? | Deletion analysis of rat GFG mitochondrial targeting. (A) Schematic representation of GFG:GFP fusion proteins. The grey, black and hatched boxes represent the GFP, nudix and mitochondrial targeting signal peptide (MTS) domains, respectively. rGFGΔ2 indicates the rGFGΔ2 isoform in which amino acids (aa) 77–145 encoded b... |
PMC2254637_F7_18239.jpg | What can you see in this picture? | Deletion analysis of rat GFG mitochondrial targeting. (A) Schematic representation of GFG:GFP fusion proteins. The grey, black and hatched boxes represent the GFP, nudix and mitochondrial targeting signal peptide (MTS) domains, respectively. rGFGΔ2 indicates the rGFGΔ2 isoform in which amino acids (aa) 77–145 encoded b... |
PMC2254641_F1_18230.jpg | What key item or scene is captured in this photo? | Preoperative CT scans. The preoperative CT scans clearly demonstrate the main tumor in the upper lobe of the right lung. |
PMC2254642_F1_18231.jpg | What is the focal point of this photograph? | Photograph showing nail changes secondary to docetaxel. |
PMC2254642_F1_18232.jpg | What is the focal point of this photograph? | Photograph showing nail changes secondary to docetaxel. |
PMC2254643_F5_18240.jpg | What is the principal component of this image? | Immunohistochemical staining of prostate tissue microarrays. The early stage cancers were from radical prostatectomy specimens derived from patients with clinically localized prostate cancers; while the late stage cancers were derived from transurethral resection specimens of prostate cancers that had advanced beyond t... |
PMC2254643_F5_18242.jpg | What can you see in this picture? | Immunohistochemical staining of prostate tissue microarrays. The early stage cancers were from radical prostatectomy specimens derived from patients with clinically localized prostate cancers; while the late stage cancers were derived from transurethral resection specimens of prostate cancers that had advanced beyond t... |
PMC2254956_f4_18246.jpg | What is the central feature of this picture? | Dihydroethidium labeling of RGC-5 cells. Dihydroethidium labeling of RGC-5 cells showed that only filtered light (1000 lux; C) and not serum deprivation (B) caused the detectable production of reactive oxygen species (red fluorescence, as marked by the arrows), as compared with control cells incubated in the dark in th... |
PMC2254956_f4_18244.jpg | What is the focal point of this photograph? | Dihydroethidium labeling of RGC-5 cells. Dihydroethidium labeling of RGC-5 cells showed that only filtered light (1000 lux; C) and not serum deprivation (B) caused the detectable production of reactive oxygen species (red fluorescence, as marked by the arrows), as compared with control cells incubated in the dark in th... |
PMC2254957_f3_18247.jpg | Can you identify the primary element in this image? | In vitro expression of cyclic guanosine monophosphate (cGMP) in the outer plexiform layer of a detached retina. Small pieces of retina were incubated with IBMX (a non-specific PDE inhibitor) and the particulate guanylyl cyclase (pGC) stimulator atrial natriuretic peptide (ANP). The expression of cGMP (cGMP: green color... |
PMC2254957_f3_18248.jpg | What is the principal component of this image? | In vitro expression of cyclic guanosine monophosphate (cGMP) in the outer plexiform layer of a detached retina. Small pieces of retina were incubated with IBMX (a non-specific PDE inhibitor) and the particulate guanylyl cyclase (pGC) stimulator atrial natriuretic peptide (ANP). The expression of cGMP (cGMP: green color... |
PMC2254957_f3_18249.jpg | What is the main focus of this visual representation? | In vitro expression of cyclic guanosine monophosphate (cGMP) in the outer plexiform layer of a detached retina. Small pieces of retina were incubated with IBMX (a non-specific PDE inhibitor) and the particulate guanylyl cyclase (pGC) stimulator atrial natriuretic peptide (ANP). The expression of cGMP (cGMP: green color... |
PMC2254958_f2_18252.jpg | What is the dominant medical problem in this image? | Confocal images of the sclera at the end of the 24 h nanoparticle (20 nm) transport study. A shows the control fluorescence and combined fluorescence while B shows the phase contrast images. C and D are nanoparticle exposed tissue fluorescence and combined fluorescence and phase contrast images, respectively. In each i... |
PMC2254958_f2_18250.jpg | What's the most prominent thing you notice in this picture? | Confocal images of the sclera at the end of the 24 h nanoparticle (20 nm) transport study. A shows the control fluorescence and combined fluorescence while B shows the phase contrast images. C and D are nanoparticle exposed tissue fluorescence and combined fluorescence and phase contrast images, respectively. In each i... |
PMC2254958_f2_18251.jpg | What is the focal point of this photograph? | Confocal images of the sclera at the end of the 24 h nanoparticle (20 nm) transport study. A shows the control fluorescence and combined fluorescence while B shows the phase contrast images. C and D are nanoparticle exposed tissue fluorescence and combined fluorescence and phase contrast images, respectively. In each i... |
PMC2254958_f3_18256.jpg | Describe the main subject of this image. | Confocal images of the sclera-choroid-RPE combination at the end of 24 h nanoparticle (20 nm) transport study. Panel A shows the fluorescence image and Panel B shows the combination (fluorescence plus phase contrast) image of the control sclera-choroid-RPE tissue. Panel C shows the fluorescence and Panel D shows the co... |
PMC2254958_f3_18255.jpg | What is the principal component of this image? | Confocal images of the sclera-choroid-RPE combination at the end of 24 h nanoparticle (20 nm) transport study. Panel A shows the fluorescence image and Panel B shows the combination (fluorescence plus phase contrast) image of the control sclera-choroid-RPE tissue. Panel C shows the fluorescence and Panel D shows the co... |
PMC2254958_f3_18257.jpg | What key item or scene is captured in this photo? | Confocal images of the sclera-choroid-RPE combination at the end of 24 h nanoparticle (20 nm) transport study. Panel A shows the fluorescence image and Panel B shows the combination (fluorescence plus phase contrast) image of the control sclera-choroid-RPE tissue. Panel C shows the fluorescence and Panel D shows the co... |
PMC2254960_f3_18265.jpg | What is shown in this image? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18258.jpg | What is the main focus of this visual representation? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18260.jpg | What is being portrayed in this visual content? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18268.jpg | What can you see in this picture? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18266.jpg | Describe the main subject of this image. | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18259.jpg | What stands out most in this visual? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18267.jpg | What is the dominant medical problem in this image? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18261.jpg | What is the central feature of this picture? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18264.jpg | What can you see in this picture? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254960_f3_18263.jpg | What is the central feature of this picture? | Rabbit lens αA-crystallin degradation. A shows the optical scan of a rabbit lens equatorial cryosection before MALDI matrix deposition. (B-K) MALDI molecular images indicate the distribution of the major forms of αA-crystallin in the rabbit lenses. The identities and observed m/z of these truncation products are (B) 1–... |
PMC2254963_f3_18271.jpg | What is shown in this image? | Magnetic resonance image of c-erbB2 antisense probe transfected SK-Br-3 cells. Transfected and untransfected cells, a probe culture medium, a no-probe culture medium, and distilled water were placed into Ependorf tubes and scanned using MR transactions. 1: untransfected cells, 2: no-probe culture medium, 3: transfected... |
PMC2254963_f3_18270.jpg | What is the focal point of this photograph? | Magnetic resonance image of c-erbB2 antisense probe transfected SK-Br-3 cells. Transfected and untransfected cells, a probe culture medium, a no-probe culture medium, and distilled water were placed into Ependorf tubes and scanned using MR transactions. 1: untransfected cells, 2: no-probe culture medium, 3: transfected... |
PMC2254966_f6_18275.jpg | What is shown in this image? | The presence of free DNA and ROS in the x-ray cataract. Using LSCM with fluorescent dyes for DNA and ROS, integrated sequential sections from the surface down to 120 μm beneath the lens surface revealed the following in a 3.5+ x-ray cataract that developed 5 months post-radiation: A: Free and particulate DNA is present... |
PMC2254966_f6_18276.jpg | Describe the main subject of this image. | The presence of free DNA and ROS in the x-ray cataract. Using LSCM with fluorescent dyes for DNA and ROS, integrated sequential sections from the surface down to 120 μm beneath the lens surface revealed the following in a 3.5+ x-ray cataract that developed 5 months post-radiation: A: Free and particulate DNA is present... |
PMC2254966_f6_18277.jpg | What is the principal component of this image? | The presence of free DNA and ROS in the x-ray cataract. Using LSCM with fluorescent dyes for DNA and ROS, integrated sequential sections from the surface down to 120 μm beneath the lens surface revealed the following in a 3.5+ x-ray cataract that developed 5 months post-radiation: A: Free and particulate DNA is present... |
PMC2254966_f7_18274.jpg | What is shown in this image? | Loss of surface LEC by death and by abnormal migration in the x-ray cataract. This confocal view shows the loss of surface LEC and their descent into the lens interior at a site well anterior to the lens equator. The irradiated animal is five months post-irradiation. This picture is made from “stacked” multiple images ... |
PMC2254966_f8_18272.jpg | What is shown in this image? | The DNA adduct 8-OHG is present in surface LEC nuclei in the x-ray cataract. Direct antibody for 8-OHG was applied followed by secondary fluorescent antibody staining in a Carnoy’s fixed paraffin section. The non-irradiated animal’s lens is on the left and the irradiated is on the right, both observed 72 h post-irradia... |
PMC2254966_f8_18273.jpg | Can you identify the primary element in this image? | The DNA adduct 8-OHG is present in surface LEC nuclei in the x-ray cataract. Direct antibody for 8-OHG was applied followed by secondary fluorescent antibody staining in a Carnoy’s fixed paraffin section. The non-irradiated animal’s lens is on the left and the irradiated is on the right, both observed 72 h post-irradia... |
PMC2254968_f3_18279.jpg | What is shown in this image? | Formation of secondary sphere. (A, B) Secondary spheres were generated after the dissociation of primary spheres derived from peripheral or central keratocytes. Scale bar=100 μm. (C) The re-plating efficiency from primary to secondary colonies was higher for spheres derived from the peripheral stroma than for those fro... |
PMC2254968_f4_18290.jpg | What is the central feature of this picture? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18287.jpg | What stands out most in this visual? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18284.jpg | Can you identify the primary element in this image? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18296.jpg | What is being portrayed in this visual content? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18291.jpg | Can you identify the primary element in this image? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18282.jpg | What does this image primarily show? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18288.jpg | What is the principal component of this image? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18297.jpg | What's the most prominent thing you notice in this picture? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
PMC2254968_f4_18292.jpg | What is the principal component of this image? | Immunocytochemical analysis of sphere colonies from the peripheral stroma on day 7. Bright-field images and immunostaining of spheres are shown. The spheres were stained for vimentin (a mesenchymal cell marker), \alpha-smooth muscle actin (α-SMA, a mesenchymal cell marker), cytokeratin 3 (a differentiated epithelial ce... |
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