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PMC2249706_pone-0001734-g005_18001.jpg | What stands out most in this visual? | Treatment attenuated target organ injury.(A) Example of a dense cataract observed only in untreated diabetic pigs. (B) Retinal fluorescein angiography showed normal capillary permeability. (C) TEM of retina showed thickened basement membrane of a choroidal capillary, duplicated basement membrane (red arrow) and an extr... |
PMC2249706_pone-0001734-g005_18002.jpg | What object or scene is depicted here? | Treatment attenuated target organ injury.(A) Example of a dense cataract observed only in untreated diabetic pigs. (B) Retinal fluorescein angiography showed normal capillary permeability. (C) TEM of retina showed thickened basement membrane of a choroidal capillary, duplicated basement membrane (red arrow) and an extr... |
PMC2249924_pone-0001647-g003_18005.jpg | What object or scene is depicted here? | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2249924_pone-0001647-g003_18008.jpg | What object or scene is depicted here? | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2249924_pone-0001647-g003_18011.jpg | What is the main focus of this visual representation? | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2249924_pone-0001647-g003_18010.jpg | What is the focal point of this photograph? | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2249924_pone-0001647-g003_18009.jpg | Describe the main subject of this image. | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2249924_pone-0001647-g003_18007.jpg | What is shown in this image? | CD8 transport to the plasma membrane is accelerated through unstacked Golgi membranes.(A) Metaphase NRK cells were microinjected with affinity-purified antibodies against GRASP65 together with a plasmid encoding the plasma membrane protein CD8. After cell division, CD8 was expressed in the daughter cells and transporte... |
PMC2250804_pone-0001649-g002_18013.jpg | What is the main focus of this visual representation? | Endothelial transmigratory cup formation.Electron micrographs and cartoons of transmigrating wild-type neutrophils where the endothelium forms a transmigratory cup (A, B and C). The arrowheads mark the junctions and L marks the lumen of the blood vessel. e1, e2 and n represent individual endothelial cells and neutrophi... |
PMC2250804_pone-0001649-g002_18014.jpg | What is the core subject represented in this visual? | Endothelial transmigratory cup formation.Electron micrographs and cartoons of transmigrating wild-type neutrophils where the endothelium forms a transmigratory cup (A, B and C). The arrowheads mark the junctions and L marks the lumen of the blood vessel. e1, e2 and n represent individual endothelial cells and neutrophi... |
PMC2250804_pone-0001649-g002_18012.jpg | What is being portrayed in this visual content? | Endothelial transmigratory cup formation.Electron micrographs and cartoons of transmigrating wild-type neutrophils where the endothelium forms a transmigratory cup (A, B and C). The arrowheads mark the junctions and L marks the lumen of the blood vessel. e1, e2 and n represent individual endothelial cells and neutrophi... |
PMC2250804_pone-0001649-g002_18015.jpg | What is the dominant medical problem in this image? | Endothelial transmigratory cup formation.Electron micrographs and cartoons of transmigrating wild-type neutrophils where the endothelium forms a transmigratory cup (A, B and C). The arrowheads mark the junctions and L marks the lumen of the blood vessel. e1, e2 and n represent individual endothelial cells and neutrophi... |
PMC2250804_pone-0001649-g003_18021.jpg | What is the dominant medical problem in this image? | Endothelial enscapsulation of transmigrating neutrophils.Electron micrographs and cartoons of transmigrating wild-type (A) and Mac-1 deficient neutrophils (B). The arrowheads mark the junctions seen in A, the thin endothelial sheet that covers the transmigrating cells is marked with *, e1, e2 and n represent individual... |
PMC2250804_pone-0001649-g003_18018.jpg | What is the central feature of this picture? | Endothelial enscapsulation of transmigrating neutrophils.Electron micrographs and cartoons of transmigrating wild-type (A) and Mac-1 deficient neutrophils (B). The arrowheads mark the junctions seen in A, the thin endothelial sheet that covers the transmigrating cells is marked with *, e1, e2 and n represent individual... |
PMC2250804_pone-0001649-g003_18019.jpg | What object or scene is depicted here? | Endothelial enscapsulation of transmigrating neutrophils.Electron micrographs and cartoons of transmigrating wild-type (A) and Mac-1 deficient neutrophils (B). The arrowheads mark the junctions seen in A, the thin endothelial sheet that covers the transmigrating cells is marked with *, e1, e2 and n represent individual... |
PMC2253502_F1_18028.jpg | What object or scene is depicted here? | Gross photograph showing cut surface of right lobe of thyroid demonstrating a well circumscribed black colored nodule, (1a); photomicrograph shows encapsulated nodule compressing adjacent normal thyroid (1b, H&E, ×100); caught up normal thyroid follicles in the tumor (1c, H&E, ×200); higher magnification demonstrating ... |
PMC2253502_F1_18027.jpg | What stands out most in this visual? | Gross photograph showing cut surface of right lobe of thyroid demonstrating a well circumscribed black colored nodule, (1a); photomicrograph shows encapsulated nodule compressing adjacent normal thyroid (1b, H&E, ×100); caught up normal thyroid follicles in the tumor (1c, H&E, ×200); higher magnification demonstrating ... |
PMC2253502_F1_18026.jpg | What key item or scene is captured in this photo? | Gross photograph showing cut surface of right lobe of thyroid demonstrating a well circumscribed black colored nodule, (1a); photomicrograph shows encapsulated nodule compressing adjacent normal thyroid (1b, H&E, ×100); caught up normal thyroid follicles in the tumor (1c, H&E, ×200); higher magnification demonstrating ... |
PMC2253502_F1_18029.jpg | What key item or scene is captured in this photo? | Gross photograph showing cut surface of right lobe of thyroid demonstrating a well circumscribed black colored nodule, (1a); photomicrograph shows encapsulated nodule compressing adjacent normal thyroid (1b, H&E, ×100); caught up normal thyroid follicles in the tumor (1c, H&E, ×200); higher magnification demonstrating ... |
PMC2253502_F3_18022.jpg | What is the focal point of this photograph? | Electronmicrographs showing oval to spindle shaped cells with prominent nucleoli (a, ×2250 original magnification) packed with compound melanosomes and premelanosomes (b, ×6250); higher magnification of premelanosomes demonstrating internal structure (c, ×8250) and electron dense neurosecretory granules (d, ×6250). |
PMC2253502_F3_18024.jpg | What object or scene is depicted here? | Electronmicrographs showing oval to spindle shaped cells with prominent nucleoli (a, ×2250 original magnification) packed with compound melanosomes and premelanosomes (b, ×6250); higher magnification of premelanosomes demonstrating internal structure (c, ×8250) and electron dense neurosecretory granules (d, ×6250). |
PMC2253502_F3_18023.jpg | Describe the main subject of this image. | Electronmicrographs showing oval to spindle shaped cells with prominent nucleoli (a, ×2250 original magnification) packed with compound melanosomes and premelanosomes (b, ×6250); higher magnification of premelanosomes demonstrating internal structure (c, ×8250) and electron dense neurosecretory granules (d, ×6250). |
PMC2253502_F3_18025.jpg | What does this image primarily show? | Electronmicrographs showing oval to spindle shaped cells with prominent nucleoli (a, ×2250 original magnification) packed with compound melanosomes and premelanosomes (b, ×6250); higher magnification of premelanosomes demonstrating internal structure (c, ×8250) and electron dense neurosecretory granules (d, ×6250). |
PMC2253506_F1_18032.jpg | Can you identify the primary element in this image? | Clinical deterioration after surgery for Adolescent Idiopathic Scoliosis (AIS). Radiography and clinical appearance of a 15-year old female AIS patient with a double curve of initially 32 degrees thoracic and 28 degrees lumbar. The lumbar curve has been fused although this leads to decompensation and clinical deteriora... |
PMC2253506_F1_18033.jpg | What is shown in this image? | Clinical deterioration after surgery for Adolescent Idiopathic Scoliosis (AIS). Radiography and clinical appearance of a 15-year old female AIS patient with a double curve of initially 32 degrees thoracic and 28 degrees lumbar. The lumbar curve has been fused although this leads to decompensation and clinical deteriora... |
PMC2253511_F3_18036.jpg | Describe the main subject of this image. | MRI T2-weighted Sequence, Coronal Plane Fat Saturation image. Complex Congenital Scoliosis Patient # 5. Superior line demonstrates concave zone growth plate deficiency and inferior line demonstrates a straight growth plate. |
PMC2253511_F4_18035.jpg | What is the main focus of this visual representation? | MRI T2-weighted Sequence, Coronal Plane Image. Congenital Scoliosis from Hemivertebra Patient # 21. MRI demonstrates convex zone deficiency in the vertebral body growth plate. |
PMC2253520_F5_18039.jpg | What is the dominant medical problem in this image? | Normal angiography of coronary arteries in the same patient. |
PMC2253520_F5_18040.jpg | What key item or scene is captured in this photo? | Normal angiography of coronary arteries in the same patient. |
PMC2253521_F1_18043.jpg | Can you identify the primary element in this image? | Morphological examination of the testis tissues from young wild-type (panels A and C) and Mer3 (panels B and D) males. The control FM6 and Mer3 mutant males were obtained according to Materials and Methods. The DAPI-stained testis from the control male contained a bulging seminal vesicle (SV) (A). In contrast, a shrive... |
PMC2253521_F1_18042.jpg | What is the main focus of this visual representation? | Morphological examination of the testis tissues from young wild-type (panels A and C) and Mer3 (panels B and D) males. The control FM6 and Mer3 mutant males were obtained according to Materials and Methods. The DAPI-stained testis from the control male contained a bulging seminal vesicle (SV) (A). In contrast, a shrive... |
PMC2253521_F4_18051.jpg | What does this image primarily show? | Difference in nuclear grouping during cyst polarization between the control and Merlin mutant spermatids. Dissected testes from the control FM6 (A), Mer3 (B-E), and Mer4 (F-H) males were stained with DAPI and examined as described before. Note that while the spermatid nuclei were grouped in one area (arrow) of the cont... |
PMC2253521_F4_18045.jpg | Can you identify the primary element in this image? | Difference in nuclear grouping during cyst polarization between the control and Merlin mutant spermatids. Dissected testes from the control FM6 (A), Mer3 (B-E), and Mer4 (F-H) males were stained with DAPI and examined as described before. Note that while the spermatid nuclei were grouped in one area (arrow) of the cont... |
PMC2253521_F4_18047.jpg | What is being portrayed in this visual content? | Difference in nuclear grouping during cyst polarization between the control and Merlin mutant spermatids. Dissected testes from the control FM6 (A), Mer3 (B-E), and Mer4 (F-H) males were stained with DAPI and examined as described before. Note that while the spermatid nuclei were grouped in one area (arrow) of the cont... |
PMC2253521_F4_18046.jpg | What is the focal point of this photograph? | Difference in nuclear grouping during cyst polarization between the control and Merlin mutant spermatids. Dissected testes from the control FM6 (A), Mer3 (B-E), and Mer4 (F-H) males were stained with DAPI and examined as described before. Note that while the spermatid nuclei were grouped in one area (arrow) of the cont... |
PMC2253521_F4_18048.jpg | What is the principal component of this image? | Difference in nuclear grouping during cyst polarization between the control and Merlin mutant spermatids. Dissected testes from the control FM6 (A), Mer3 (B-E), and Mer4 (F-H) males were stained with DAPI and examined as described before. Note that while the spermatid nuclei were grouped in one area (arrow) of the cont... |
PMC2253526_F3_18053.jpg | What is shown in this image? | CT scan of abdomen showing soft tissue mass in the anterior abdominal wall (white arrow). The ventral incisional hernia is seen on this slice and was arising cranially but lies superiorly to the mass. |
PMC2253532_F4_18060.jpg | What object or scene is depicted here? | Disease evolution visualized using MRI. Pre- and post contrast T1W images (a, b), T2W (c) images together with equivalent Histological slices (d) illustrate the evolution of the disease. Postcontrast T1W images were used to identify meningeal enhancement. Meningeal enhancement could be visually graded as (from left to ... |
PMC2253532_F4_18059.jpg | What can you see in this picture? | Disease evolution visualized using MRI. Pre- and post contrast T1W images (a, b), T2W (c) images together with equivalent Histological slices (d) illustrate the evolution of the disease. Postcontrast T1W images were used to identify meningeal enhancement. Meningeal enhancement could be visually graded as (from left to ... |
PMC2253532_F5_18055.jpg | What is the dominant medical problem in this image? | Infection induced brain injury. Example of an infected rat (48 hours) with a cortical abscess (white arrow), confirmed histopathologically (a and b), apparent in post-contrast T1W- and T2W images (c and d). The damaged area identified with histology covered only 1/3 of the area with contrast enhancement. |
PMC2253532_F5_18057.jpg | What's the most prominent thing you notice in this picture? | Infection induced brain injury. Example of an infected rat (48 hours) with a cortical abscess (white arrow), confirmed histopathologically (a and b), apparent in post-contrast T1W- and T2W images (c and d). The damaged area identified with histology covered only 1/3 of the area with contrast enhancement. |
PMC2253533_F8_18062.jpg | What is shown in this image? | Micrographs showing nasal mucosal neutrophils and eosinophils 24 hours post TNFα and sham challenge. A: Sham-challenged healthy subject: biopsy stained for the neutrophil granule protein MPO. B: TNFα challenged patient with allergic rhinitis: biopsy stained for MPO. C: Sham-challenged healthy subject: biopsy stained fo... |
PMC2253533_F8_18064.jpg | Describe the main subject of this image. | Micrographs showing nasal mucosal neutrophils and eosinophils 24 hours post TNFα and sham challenge. A: Sham-challenged healthy subject: biopsy stained for the neutrophil granule protein MPO. B: TNFα challenged patient with allergic rhinitis: biopsy stained for MPO. C: Sham-challenged healthy subject: biopsy stained fo... |
PMC2253533_F8_18063.jpg | What can you see in this picture? | Micrographs showing nasal mucosal neutrophils and eosinophils 24 hours post TNFα and sham challenge. A: Sham-challenged healthy subject: biopsy stained for the neutrophil granule protein MPO. B: TNFα challenged patient with allergic rhinitis: biopsy stained for MPO. C: Sham-challenged healthy subject: biopsy stained fo... |
PMC2253533_F8_18061.jpg | What is the main focus of this visual representation? | Micrographs showing nasal mucosal neutrophils and eosinophils 24 hours post TNFα and sham challenge. A: Sham-challenged healthy subject: biopsy stained for the neutrophil granule protein MPO. B: TNFα challenged patient with allergic rhinitis: biopsy stained for MPO. C: Sham-challenged healthy subject: biopsy stained fo... |
PMC2253537_F1_18065.jpg | What is shown in this image? | CT scan showing extensive mesothelioma of the chest wall and esophagus. |
PMC2253541_F5_18066.jpg | What is being portrayed in this visual content? | Axial 3D MRI – Rectus Capitus Posterior Minor (Arrow). |
PMC2253544_F1_18069.jpg | What is the focal point of this photograph? | (a) : Breast cancer specimen with high vascular endothelial growth factor-C expression. Note the typical cytoplasmatic staining reaction, original magnification 400×. (b) : Breast cancer with high cyclooxygenase-2 expression. Typically granular staining was diffuse in cytoplasm of the cancer cells, original magnificati... |
PMC2253544_F1_18068.jpg | Can you identify the primary element in this image? | (a) : Breast cancer specimen with high vascular endothelial growth factor-C expression. Note the typical cytoplasmatic staining reaction, original magnification 400×. (b) : Breast cancer with high cyclooxygenase-2 expression. Typically granular staining was diffuse in cytoplasm of the cancer cells, original magnificati... |
PMC2253544_F1_18072.jpg | What is the focal point of this photograph? | (a) : Breast cancer specimen with high vascular endothelial growth factor-C expression. Note the typical cytoplasmatic staining reaction, original magnification 400×. (b) : Breast cancer with high cyclooxygenase-2 expression. Typically granular staining was diffuse in cytoplasm of the cancer cells, original magnificati... |
PMC2253544_F1_18067.jpg | What stands out most in this visual? | (a) : Breast cancer specimen with high vascular endothelial growth factor-C expression. Note the typical cytoplasmatic staining reaction, original magnification 400×. (b) : Breast cancer with high cyclooxygenase-2 expression. Typically granular staining was diffuse in cytoplasm of the cancer cells, original magnificati... |
PMC2253544_F1_18071.jpg | What is the principal component of this image? | (a) : Breast cancer specimen with high vascular endothelial growth factor-C expression. Note the typical cytoplasmatic staining reaction, original magnification 400×. (b) : Breast cancer with high cyclooxygenase-2 expression. Typically granular staining was diffuse in cytoplasm of the cancer cells, original magnificati... |
PMC2253549_F1_18075.jpg | What can you see in this picture? | Anteroposterior abdominal radiograph demonstrates a soft tissue mass in the right hemiabdomen. The mass contains calcified osseous-appearing structures of varying sizes and shapes (see arrows) |
PMC2253550_F1_18076.jpg | What key item or scene is captured in this photo? | Contrast enhanced CT scan showing hepatomegaly and a large hypodense lesion in the liver. |
PMC2253551_F1_18077.jpg | What key item or scene is captured in this photo? | CT scan showing tumour in the upper moiety of the crossed fused renal ectopia. |
PMC2253627_pbio-0060034-g006_18082.jpg | What's the most prominent thing you notice in this picture? | Time-Lapse Imaging of Jacob's Nuclear Translocation(A) Confocal maximal intensity image of a living hippocampal primary cultured neuron (DIV10) overexpressing WT-Jacob-GFP (green channel) and merged with a nuclear stain (DAPI) obtained after the experiment (red channel).(B) Representative selective video frames obtaine... |
PMC2253627_pbio-0060034-g006_18080.jpg | What is the main focus of this visual representation? | Time-Lapse Imaging of Jacob's Nuclear Translocation(A) Confocal maximal intensity image of a living hippocampal primary cultured neuron (DIV10) overexpressing WT-Jacob-GFP (green channel) and merged with a nuclear stain (DAPI) obtained after the experiment (red channel).(B) Representative selective video frames obtaine... |
PMC2253627_pbio-0060034-g006_18083.jpg | What's the most prominent thing you notice in this picture? | Time-Lapse Imaging of Jacob's Nuclear Translocation(A) Confocal maximal intensity image of a living hippocampal primary cultured neuron (DIV10) overexpressing WT-Jacob-GFP (green channel) and merged with a nuclear stain (DAPI) obtained after the experiment (red channel).(B) Representative selective video frames obtaine... |
PMC2253627_pbio-0060034-g007_18085.jpg | What's the most prominent thing you notice in this picture? | Nuclear Immunoreactivity of Jacob and Importin-α1 upon Different Stimulation ProtocolsDepicted are confocal images obtained from a single nuclear focal plane. Scale bar indicates 10 μm. All experiments were done in the presence of 7.5 μM anisomycin. Nuclear Jacob and Importin IR were quantified using the Image J softwa... |
PMC2253627_pbio-0060034-g007_18089.jpg | What object or scene is depicted here? | Nuclear Immunoreactivity of Jacob and Importin-α1 upon Different Stimulation ProtocolsDepicted are confocal images obtained from a single nuclear focal plane. Scale bar indicates 10 μm. All experiments were done in the presence of 7.5 μM anisomycin. Nuclear Jacob and Importin IR were quantified using the Image J softwa... |
PMC2253627_pbio-0060034-g007_18084.jpg | Describe the main subject of this image. | Nuclear Immunoreactivity of Jacob and Importin-α1 upon Different Stimulation ProtocolsDepicted are confocal images obtained from a single nuclear focal plane. Scale bar indicates 10 μm. All experiments were done in the presence of 7.5 μM anisomycin. Nuclear Jacob and Importin IR were quantified using the Image J softwa... |
PMC2253627_pbio-0060034-g007_18088.jpg | Can you identify the primary element in this image? | Nuclear Immunoreactivity of Jacob and Importin-α1 upon Different Stimulation ProtocolsDepicted are confocal images obtained from a single nuclear focal plane. Scale bar indicates 10 μm. All experiments were done in the presence of 7.5 μM anisomycin. Nuclear Jacob and Importin IR were quantified using the Image J softwa... |
PMC2253691_fig02_18096.jpg | What object or scene is depicted here? | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig02_18095.jpg | What's the most prominent thing you notice in this picture? | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig02_18093.jpg | Describe the main subject of this image. | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig02_18092.jpg | What does this image primarily show? | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig02_18097.jpg | What is shown in this image? | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig02_18098.jpg | What object or scene is depicted here? | Intracellular translocation of SteC-2HA requires a functional SPI-2 T3SS. A. In vitro secretion of SteC-2HA. Wild-type and ssaV mutant strains expressing 2HA-tagged SteC were grown overnight in SPI-2-inducing conditions and bacterial cell pellet and extracellular proteins (plastic) were analysed by immunoblotting. B an... |
PMC2253691_fig05_18108.jpg | What is being portrayed in this visual content? | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18101.jpg | What does this image primarily show? | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18103.jpg | Describe the main subject of this image. | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18104.jpg | Describe the main subject of this image. | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18102.jpg | What is being portrayed in this visual content? | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18109.jpg | What object or scene is depicted here? | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253691_fig05_18105.jpg | What object or scene is depicted here? | Intracellular F-actin reorganization by Salmonella is dependent on the Lys256 of SteC. A. Representative confocal images of Swiss 3T3 fibroblasts infected for 8 h with an steC mutant containing plasmid-borne steC-2HA, or steCK256H-2HA. Cells were immunolabelled to detect Salmonella (green in merged image). F-actin was ... |
PMC2253695_fig03_18111.jpg | What can you see in this picture? | Lung histology in WT and TLR2 KO mice after infection with S. pneumoniae PLN. Representative lung tissue slides from WT mice (A, C and E) and TLR2 KO mice (B, D and F) after infection with 5 × 107 cfu S. pneumoniae PLN. Mice were sacrificed after 24 h (A and B), 48 h (C and D) or 72 h (E and F). HE staining: magnificat... |
PMC2253695_fig03_18114.jpg | What is the focal point of this photograph? | Lung histology in WT and TLR2 KO mice after infection with S. pneumoniae PLN. Representative lung tissue slides from WT mice (A, C and E) and TLR2 KO mice (B, D and F) after infection with 5 × 107 cfu S. pneumoniae PLN. Mice were sacrificed after 24 h (A and B), 48 h (C and D) or 72 h (E and F). HE staining: magnificat... |
PMC2253695_fig03_18110.jpg | What is the principal component of this image? | Lung histology in WT and TLR2 KO mice after infection with S. pneumoniae PLN. Representative lung tissue slides from WT mice (A, C and E) and TLR2 KO mice (B, D and F) after infection with 5 × 107 cfu S. pneumoniae PLN. Mice were sacrificed after 24 h (A and B), 48 h (C and D) or 72 h (E and F). HE staining: magnificat... |
PMC2253695_fig03_18115.jpg | What is the core subject represented in this visual? | Lung histology in WT and TLR2 KO mice after infection with S. pneumoniae PLN. Representative lung tissue slides from WT mice (A, C and E) and TLR2 KO mice (B, D and F) after infection with 5 × 107 cfu S. pneumoniae PLN. Mice were sacrificed after 24 h (A and B), 48 h (C and D) or 72 h (E and F). HE staining: magnificat... |
PMC2253695_fig04_18116.jpg | What stands out most in this visual? | Reduced lung inflammation in TLR2 KO mice early after infection with S. pneumoniae D39 or S. pneumoniae PLN. Representative lung tissue slides from WT mice (A and C) and TLR2 KO mice (B and D) 6 h after infection with 5 × 107 cfu S. pneumoniae D39 (A and B) or S. pneumoniae PLN (C and D). HE staining: magnification 4×.... |
PMC2253695_fig04_18119.jpg | What is the main focus of this visual representation? | Reduced lung inflammation in TLR2 KO mice early after infection with S. pneumoniae D39 or S. pneumoniae PLN. Representative lung tissue slides from WT mice (A and C) and TLR2 KO mice (B and D) 6 h after infection with 5 × 107 cfu S. pneumoniae D39 (A and B) or S. pneumoniae PLN (C and D). HE staining: magnification 4×.... |
PMC2253695_fig04_18117.jpg | Describe the main subject of this image. | Reduced lung inflammation in TLR2 KO mice early after infection with S. pneumoniae D39 or S. pneumoniae PLN. Representative lung tissue slides from WT mice (A and C) and TLR2 KO mice (B and D) 6 h after infection with 5 × 107 cfu S. pneumoniae D39 (A and B) or S. pneumoniae PLN (C and D). HE staining: magnification 4×.... |
PMC2253695_fig04_18118.jpg | What is the core subject represented in this visual? | Reduced lung inflammation in TLR2 KO mice early after infection with S. pneumoniae D39 or S. pneumoniae PLN. Representative lung tissue slides from WT mice (A and C) and TLR2 KO mice (B and D) 6 h after infection with 5 × 107 cfu S. pneumoniae D39 (A and B) or S. pneumoniae PLN (C and D). HE staining: magnification 4×.... |
PMC2253716_fig02_18124.jpg | What is the central feature of this picture? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18131.jpg | What is being portrayed in this visual content? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18121.jpg | What key item or scene is captured in this photo? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18127.jpg | What does this image primarily show? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18128.jpg | What is the dominant medical problem in this image? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18125.jpg | What is the core subject represented in this visual? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18122.jpg | What is the dominant medical problem in this image? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18130.jpg | What is the main focus of this visual representation? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18123.jpg | Can you identify the primary element in this image? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18126.jpg | What is the core subject represented in this visual? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18129.jpg | What key item or scene is captured in this photo? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253716_fig02_18120.jpg | What is the core subject represented in this visual? | Immunohistochemical analysis of SBEM expression in the small panel of 10 human breast cancers. Immunohistochemistry was performed as described in Materials and Methods. Patient/sample identification is indicated on top left of each picture, and the corresponding H-score for IHC is presented on the bottom right corner. ... |
PMC2253826_pone-0001732-g005_18143.jpg | What is shown in this image? | Spatial localization of PfAARP by co-immunostaining studies with microneme resident proteins AMA-1 (A) and EBA-175 (B).
P. falciparum parasites were co-immunostained with anti-PfAARP (green) and anti-AMA-1 or anti-EBA-175 (red) antibodies. The parasite nuclei were stained with DAPI (blue). Both the microneme markers an... |
PMC2253826_pone-0001732-g005_18141.jpg | What's the most prominent thing you notice in this picture? | Spatial localization of PfAARP by co-immunostaining studies with microneme resident proteins AMA-1 (A) and EBA-175 (B).
P. falciparum parasites were co-immunostained with anti-PfAARP (green) and anti-AMA-1 or anti-EBA-175 (red) antibodies. The parasite nuclei were stained with DAPI (blue). Both the microneme markers an... |
PMC2254193_pone-0001741-g005_18147.jpg | What stands out most in this visual? | S100A7 downregulation decreases osteolytic lesions in vivo.
Cells were directly introduced into the tibias of 4 week-old mice, as described in Materials and Methods. Micro-CT scanning of live mice was done using a GE eXplore Micro-CT scanner (GE Healthcare Ltd, UK) at 93 µm resolution, 6 weeks after injection. The tibi... |
PMC2254193_pone-0001741-g005_18146.jpg | What stands out most in this visual? | S100A7 downregulation decreases osteolytic lesions in vivo.
Cells were directly introduced into the tibias of 4 week-old mice, as described in Materials and Methods. Micro-CT scanning of live mice was done using a GE eXplore Micro-CT scanner (GE Healthcare Ltd, UK) at 93 µm resolution, 6 weeks after injection. The tibi... |
PMC2254193_pone-0001741-g005_18148.jpg | What is the dominant medical problem in this image? | S100A7 downregulation decreases osteolytic lesions in vivo.
Cells were directly introduced into the tibias of 4 week-old mice, as described in Materials and Methods. Micro-CT scanning of live mice was done using a GE eXplore Micro-CT scanner (GE Healthcare Ltd, UK) at 93 µm resolution, 6 weeks after injection. The tibi... |
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