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PMC2410174_fig1_23923.jpg | What is the focal point of this photograph? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23928.jpg | What is the dominant medical problem in this image? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23924.jpg | What is the principal component of this image? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23930.jpg | What stands out most in this visual? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23931.jpg | What object or scene is depicted here? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410215_fig1_23935.jpg | What is the dominant medical problem in this image? | Evidence of clinical response during CC-5013 treatment. (A) Patient SR9 exhibited extensive nodular cutaneous disease over his left thigh. Following treatment (B) lesions became flattened and attenuated. (C) Patient PB13 shows mediastinal mass (arrowed) on CT scan which is reduced (D) after treatment. |
PMC2410215_fig1_23936.jpg | What object or scene is depicted here? | Evidence of clinical response during CC-5013 treatment. (A) Patient SR9 exhibited extensive nodular cutaneous disease over his left thigh. Following treatment (B) lesions became flattened and attenuated. (C) Patient PB13 shows mediastinal mass (arrowed) on CT scan which is reduced (D) after treatment. |
PMC2410215_fig1_23937.jpg | Describe the main subject of this image. | Evidence of clinical response during CC-5013 treatment. (A) Patient SR9 exhibited extensive nodular cutaneous disease over his left thigh. Following treatment (B) lesions became flattened and attenuated. (C) Patient PB13 shows mediastinal mass (arrowed) on CT scan which is reduced (D) after treatment. |
PMC2410215_fig1_23933.jpg | What is the focal point of this photograph? | Evidence of clinical response during CC-5013 treatment. (A) Patient SR9 exhibited extensive nodular cutaneous disease over his left thigh. Following treatment (B) lesions became flattened and attenuated. (C) Patient PB13 shows mediastinal mass (arrowed) on CT scan which is reduced (D) after treatment. |
PMC2410236_F2_23942.jpg | What is the central feature of this picture? | Immunofluorescence localization of pan-cadherin (panel a), alpha-catenin (panel b), and beta-catenin (panel c) in the LI90 cells cultured on glass-cover-slip in the bottom of culture dishes. Nuclei of the cultured cells were counterstained with propidium iodide (panel a–d). The cultured cells were examined with an LSM ... |
PMC2410236_F2_23940.jpg | What is the central feature of this picture? | Immunofluorescence localization of pan-cadherin (panel a), alpha-catenin (panel b), and beta-catenin (panel c) in the LI90 cells cultured on glass-cover-slip in the bottom of culture dishes. Nuclei of the cultured cells were counterstained with propidium iodide (panel a–d). The cultured cells were examined with an LSM ... |
PMC2410236_F2_23941.jpg | What key item or scene is captured in this photo? | Immunofluorescence localization of pan-cadherin (panel a), alpha-catenin (panel b), and beta-catenin (panel c) in the LI90 cells cultured on glass-cover-slip in the bottom of culture dishes. Nuclei of the cultured cells were counterstained with propidium iodide (panel a–d). The cultured cells were examined with an LSM ... |
PMC2410245_F3_23943.jpg | Can you identify the primary element in this image? | Transmission and scanning electron micrographs of baboon livers. In the young baboon (a & c) the endothelium (E) is thin & fenestrated and the space of Disse (D) is free of fibrosis. In the old baboon (b & d) the endothelium is thickened & defenestrated. H and L indicate the hepatocyte and sinusoidal lumen, respectivel... |
PMC2410245_F3_23944.jpg | What does this image primarily show? | Transmission and scanning electron micrographs of baboon livers. In the young baboon (a & c) the endothelium (E) is thin & fenestrated and the space of Disse (D) is free of fibrosis. In the old baboon (b & d) the endothelium is thickened & defenestrated. H and L indicate the hepatocyte and sinusoidal lumen, respectivel... |
PMC2410245_F3_23945.jpg | What does this image primarily show? | Transmission and scanning electron micrographs of baboon livers. In the young baboon (a & c) the endothelium (E) is thin & fenestrated and the space of Disse (D) is free of fibrosis. In the old baboon (b & d) the endothelium is thickened & defenestrated. H and L indicate the hepatocyte and sinusoidal lumen, respectivel... |
PMC2410248_F2_23948.jpg | What is the core subject represented in this visual? | Immunodetection of desmin positive HSCs in PLC-enriched fraction. The cell fractions obtained from normal (A) and PHx rats at 1 day (B), 3 days (C), and 7 days (D) after PHx. Bar = 100 –m. |
PMC2410248_F2_23950.jpg | What is the dominant medical problem in this image? | Immunodetection of desmin positive HSCs in PLC-enriched fraction. The cell fractions obtained from normal (A) and PHx rats at 1 day (B), 3 days (C), and 7 days (D) after PHx. Bar = 100 –m. |
PMC2410248_F2_23947.jpg | What key item or scene is captured in this photo? | Immunodetection of desmin positive HSCs in PLC-enriched fraction. The cell fractions obtained from normal (A) and PHx rats at 1 day (B), 3 days (C), and 7 days (D) after PHx. Bar = 100 –m. |
PMC2410248_F2_23949.jpg | What is the principal component of this image? | Immunodetection of desmin positive HSCs in PLC-enriched fraction. The cell fractions obtained from normal (A) and PHx rats at 1 day (B), 3 days (C), and 7 days (D) after PHx. Bar = 100 –m. |
PMC2412852_F1_23960.jpg | What key item or scene is captured in this photo? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23959.jpg | What object or scene is depicted here? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23954.jpg | What's the most prominent thing you notice in this picture? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23953.jpg | What is being portrayed in this visual content? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23956.jpg | Can you identify the primary element in this image? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23957.jpg | What's the most prominent thing you notice in this picture? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23958.jpg | What is the central feature of this picture? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412852_F1_23955.jpg | Can you identify the primary element in this image? | Grade 3 colitis with tremelimumab. High magnification images of a biopsy of the colon in patient 1114. Sections from paraffin-embedded tissue were stained by hematoxylin-eosin (H&E) and CD3, CD4, CD8, CD68, and granzyme B by immunohistochemistry using commercially available antibodies. |
PMC2412858_F5_23963.jpg | What is the dominant medical problem in this image? | Plaque size comparison between rpOka and rpOkaΔ58 in MRC-5 cells. Plaque sizes after infection with cell-free rpOka and rpOkaΔ58 are indicated graphically (upper) and in photographs (lower). MRC-5 cells were infected with each cell-free virus and cultured for 10 days. The cells were fixed and stained with 1% crystal vi... |
PMC2412858_F5_23962.jpg | What key item or scene is captured in this photo? | Plaque size comparison between rpOka and rpOkaΔ58 in MRC-5 cells. Plaque sizes after infection with cell-free rpOka and rpOkaΔ58 are indicated graphically (upper) and in photographs (lower). MRC-5 cells were infected with each cell-free virus and cultured for 10 days. The cells were fixed and stained with 1% crystal vi... |
PMC2412858_F6_23965.jpg | What is the focal point of this photograph? | Plaque size comparison between rpOka and rpOkaΔ58 in MeWo cells. Plaque sizes after infection with cell-free rpOka and rpOkaΔ58 are indicated graphically (upper) and in photographs (lower). MeWo cells were infected with each cell-free virus and cultured for 10 days. The cells were fixed and stained with 1% crystal viol... |
PMC2412858_F6_23964.jpg | What does this image primarily show? | Plaque size comparison between rpOka and rpOkaΔ58 in MeWo cells. Plaque sizes after infection with cell-free rpOka and rpOkaΔ58 are indicated graphically (upper) and in photographs (lower). MeWo cells were infected with each cell-free virus and cultured for 10 days. The cells were fixed and stained with 1% crystal viol... |
PMC2412868_F1_23970.jpg | What can you see in this picture? | Computerized tomography A) and B); evaluation of the liver demonstrated a large inhomogeneous mass with multiple areas of cystic component within the left lobe of the liver. The mass measured 17.6 × 14 cm. Mild dilatation of the intrahepatic biliary radicals in the right lobe liver. |
PMC2412868_F1_23969.jpg | What does this image primarily show? | Computerized tomography A) and B); evaluation of the liver demonstrated a large inhomogeneous mass with multiple areas of cystic component within the left lobe of the liver. The mass measured 17.6 × 14 cm. Mild dilatation of the intrahepatic biliary radicals in the right lobe liver. |
PMC2412868_F2_23967.jpg | What is shown in this image? | computerized tomography A) and B); mass in the left lobe of the liver has decreased in size with respect to the prior study. |
PMC2412868_F2_23968.jpg | What object or scene is depicted here? | computerized tomography A) and B); mass in the left lobe of the liver has decreased in size with respect to the prior study. |
PMC2412868_F4_23971.jpg | What is being portrayed in this visual content? | Computerized tomography A) and B); no evidence of metastatic disease. |
PMC2412868_F4_23972.jpg | Can you identify the primary element in this image? | Computerized tomography A) and B); no evidence of metastatic disease. |
PMC2412891_F3_23975.jpg | What does this image primarily show? | Plain CT scan. Diffuse swelling is seen in the left iliopsoas muscle and there is a ring-like hypodense local swelling with a high-density rim noted in the left iliacus muscle. |
PMC2412891_F4_23974.jpg | What is shown in this image? | Plain CT scan of the abdomen showing intraperitoneal fluid which turned out to be haemoperitoneum. |
PMC2412892_F1_23973.jpg | What is the dominant medical problem in this image? | MRI – transverse plan (L4) with IV contrast gadolinium-BOPTA, revealing a well-defined mass, a huge retroperitoneal hematoma. |
PMC2412892_F2_23977.jpg | Can you identify the primary element in this image? | MRI – axial plan showing a large, mixed density mass in the right side of the abdomen suggestive of a large retroperitoneal hematoma, with areas of hyperdensity (arrows) indicating ongoing hemorrhage. |
PMC2412892_F3_23976.jpg | Can you identify the primary element in this image? | MRI – coronar plan. |
PMC2412893_F2_23980.jpg | What is the main focus of this visual representation? | Magnetic resonance imaging of the right knee. |
PMC2412893_F2_23978.jpg | What stands out most in this visual? | Magnetic resonance imaging of the right knee. |
PMC2413012_pone-0002455-g005_23981.jpg | What is the dominant medical problem in this image? | Mitochondrial abnormalities in PINK1 deficient neurons.A) PINK deficiency leads to a reduced basal mitochondrial membrane potential (ψm) in young PINK1 kd neurons compared to controls, analysed using TMRM fluorescence. Values are mean percentages of the control cultures (normalised to 100%) from three independent exper... |
PMC2413012_pone-0002455-g005_23982.jpg | What is the focal point of this photograph? | Mitochondrial abnormalities in PINK1 deficient neurons.A) PINK deficiency leads to a reduced basal mitochondrial membrane potential (ψm) in young PINK1 kd neurons compared to controls, analysed using TMRM fluorescence. Values are mean percentages of the control cultures (normalised to 100%) from three independent exper... |
PMC2413012_pone-0002455-g005_23983.jpg | What can you see in this picture? | Mitochondrial abnormalities in PINK1 deficient neurons.A) PINK deficiency leads to a reduced basal mitochondrial membrane potential (ψm) in young PINK1 kd neurons compared to controls, analysed using TMRM fluorescence. Values are mean percentages of the control cultures (normalised to 100%) from three independent exper... |
PMC2413012_pone-0002455-g005_23986.jpg | What is the core subject represented in this visual? | Mitochondrial abnormalities in PINK1 deficient neurons.A) PINK deficiency leads to a reduced basal mitochondrial membrane potential (ψm) in young PINK1 kd neurons compared to controls, analysed using TMRM fluorescence. Values are mean percentages of the control cultures (normalised to 100%) from three independent exper... |
PMC2413233_F1_23992.jpg | Can you identify the primary element in this image? | Midventricular short axis images from the standard acquisition (upper) and TSENSE accelerated single breath-hold acquisition (lower), at end-diastole (left) and end-systole (right), from the same patient. |
PMC2413233_F1_23990.jpg | What is being portrayed in this visual content? | Midventricular short axis images from the standard acquisition (upper) and TSENSE accelerated single breath-hold acquisition (lower), at end-diastole (left) and end-systole (right), from the same patient. |
PMC2413233_F1_23989.jpg | What key item or scene is captured in this photo? | Midventricular short axis images from the standard acquisition (upper) and TSENSE accelerated single breath-hold acquisition (lower), at end-diastole (left) and end-systole (right), from the same patient. |
PMC2413234_F2_23994.jpg | What is shown in this image? | Electron micrographs of portion of seminiferous tubule of rat from CG. In A, the SC showing nucleus (S) with evident nucleolus (arrowhead), smooth endoplasmic reticulum (Ser) and lipid inclusions (Li), is adjacent to the peritubular tissue (PT). ×11,000. In B (high magnification of A), a well defined epithelial basal l... |
PMC2413234_F2_23993.jpg | What object or scene is depicted here? | Electron micrographs of portion of seminiferous tubule of rat from CG. In A, the SC showing nucleus (S) with evident nucleolus (arrowhead), smooth endoplasmic reticulum (Ser) and lipid inclusions (Li), is adjacent to the peritubular tissue (PT). ×11,000. In B (high magnification of A), a well defined epithelial basal l... |
PMC2413234_F3_23995.jpg | Can you identify the primary element in this image? | Electron micrographs of portions of seminiferous tubules of rats from CmG. In A, the irregular outlined tubule shows SC nucleus with normal aspect (S) and evident nucleolus (black arrowhead). Mitochondria with tubular cristae (Mi), smooth endoplasmic reticulum (Ser) and lipid inclusion (Li) are observed. Portions of th... |
PMC2413234_F3_23996.jpg | What is the core subject represented in this visual? | Electron micrographs of portions of seminiferous tubules of rats from CmG. In A, the irregular outlined tubule shows SC nucleus with normal aspect (S) and evident nucleolus (black arrowhead). Mitochondria with tubular cristae (Mi), smooth endoplasmic reticulum (Ser) and lipid inclusion (Li) are observed. Portions of th... |
PMC2413251_F1_23999.jpg | What stands out most in this visual? | MRI demonstrating extensive medullary signal abnormality over the distal femur and proximal tibia with a large haemarthrosis. (A) T1-weighted axial, (B) T2-weighted coronal and (C) T1-weighted sagittal views of the lesion. |
PMC2413251_F1_23997.jpg | What key item or scene is captured in this photo? | MRI demonstrating extensive medullary signal abnormality over the distal femur and proximal tibia with a large haemarthrosis. (A) T1-weighted axial, (B) T2-weighted coronal and (C) T1-weighted sagittal views of the lesion. |
PMC2413251_F1_23998.jpg | What is shown in this image? | MRI demonstrating extensive medullary signal abnormality over the distal femur and proximal tibia with a large haemarthrosis. (A) T1-weighted axial, (B) T2-weighted coronal and (C) T1-weighted sagittal views of the lesion. |
PMC2413251_F2_24000.jpg | What is the main focus of this visual representation? | Histological section from the initial resected distal femur demonstrating cystic spaces that are lined by fibrous septa that contain areas of haemosiderin deposition and recent haemorrhage. Features were consistent with haemorrhagic aneurysmal bone cyst. No evidence of malignancy seen. (Haematoxylin and eosin staining,... |
PMC2413251_F2_24001.jpg | Describe the main subject of this image. | Histological section from the initial resected distal femur demonstrating cystic spaces that are lined by fibrous septa that contain areas of haemosiderin deposition and recent haemorrhage. Features were consistent with haemorrhagic aneurysmal bone cyst. No evidence of malignancy seen. (Haematoxylin and eosin staining,... |
PMC2413251_F4_24002.jpg | What is the focal point of this photograph? | Histological section after hindquarter amputation demonstrating large dilated vascular spaces (V) lined by a dense population of atypical plump endothelial-like cells (T and arrow) which are surrounded by disorganized small diameter vascular channels. These features are consistent with angiosarcoma. (Haematoxylin & eos... |
PMC2413255_F3_24017.jpg | What is shown in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24005.jpg | What is shown in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24010.jpg | What stands out most in this visual? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24015.jpg | What can you see in this picture? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24012.jpg | What is shown in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24003.jpg | What is the dominant medical problem in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24006.jpg | What object or scene is depicted here? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24019.jpg | What stands out most in this visual? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24011.jpg | What is shown in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24004.jpg | What is the dominant medical problem in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24009.jpg | What is the principal component of this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24008.jpg | What is the principal component of this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24013.jpg | What can you see in this picture? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413255_F3_24014.jpg | Can you identify the primary element in this image? | VHR expression and localization in cervix cell lines and primary keratinocytes. A/ Immunochemistry of VHR in primary keratinocytes (a), in HPV positive, HeLa (b), SiHa (c) and CaSki (d) and HPV negative C33 (e) and HT3 (f) cell lines. Brown indicates the VHR specific staining and blue represents the hematoxylin stainin... |
PMC2413258_F1_24020.jpg | What can you see in this picture? | Axial section computed tomography scan demonstrating hyperdensity in the left sigmoid sinus. |
PMC2413406_pone-0002434-g002_24026.jpg | What is the central feature of this picture? | Binding of barnase and scFv 4D5-dibarnase to cells.The cell-binding ability of the recombinant proteins demonstrated by fluorescent microscopy. Cells were incubated at 4°C for 1 h with either 20 nM scFv 4D5-dibarnase (A, B and D), or a mixture of 20 nM scFv 4D5-dibarnase and 20 nM scFv 4D5 (C), or 20 µM barnase (E). Un... |
PMC2413406_pone-0002434-g002_24025.jpg | What can you see in this picture? | Binding of barnase and scFv 4D5-dibarnase to cells.The cell-binding ability of the recombinant proteins demonstrated by fluorescent microscopy. Cells were incubated at 4°C for 1 h with either 20 nM scFv 4D5-dibarnase (A, B and D), or a mixture of 20 nM scFv 4D5-dibarnase and 20 nM scFv 4D5 (C), or 20 µM barnase (E). Un... |
PMC2413406_pone-0002434-g002_24024.jpg | What is shown in this image? | Binding of barnase and scFv 4D5-dibarnase to cells.The cell-binding ability of the recombinant proteins demonstrated by fluorescent microscopy. Cells were incubated at 4°C for 1 h with either 20 nM scFv 4D5-dibarnase (A, B and D), or a mixture of 20 nM scFv 4D5-dibarnase and 20 nM scFv 4D5 (C), or 20 µM barnase (E). Un... |
PMC2413406_pone-0002434-g003_24022.jpg | What is the principal component of this image? | Binding and internalization of scFv 4D5-dibarnase in BT-474 cells visualized by confocal microscopy.(A) Cells were incubated with scFv 4D5-dibarnase at 4°C or (B) at 37°C. The scFv 4D5-dibarnase was detected with rabbit anti-barnase antiserum followed by GAR-PE. Fluorescence was observed predominantly on the surface of... |
PMC2413406_pone-0002434-g003_24023.jpg | What is shown in this image? | Binding and internalization of scFv 4D5-dibarnase in BT-474 cells visualized by confocal microscopy.(A) Cells were incubated with scFv 4D5-dibarnase at 4°C or (B) at 37°C. The scFv 4D5-dibarnase was detected with rabbit anti-barnase antiserum followed by GAR-PE. Fluorescence was observed predominantly on the surface of... |
PMC2413406_pone-0002434-g007_24031.jpg | What is the focal point of this photograph? | SKOV-3 cells treated with either barnase or scFv 4D5-dibarnase for 72 h demonstrated membrane blebbing.(A) The mock-treated cells were attached to the plate and were flat. (B and C) Cells incubated with either 50 µM barnase or 50 nM scFv 4D5-dibarnase became rounded and detached. Membrane blebbing (B and C, asterisks) ... |
PMC2413406_pone-0002434-g007_24030.jpg | What is being portrayed in this visual content? | SKOV-3 cells treated with either barnase or scFv 4D5-dibarnase for 72 h demonstrated membrane blebbing.(A) The mock-treated cells were attached to the plate and were flat. (B and C) Cells incubated with either 50 µM barnase or 50 nM scFv 4D5-dibarnase became rounded and detached. Membrane blebbing (B and C, asterisks) ... |
PMC2413497_pgen-1000102-g001_24041.jpg | What does this image primarily show? | Glue Genes are Induced by 20E in Cultured Glands.Mid-L3 animals were torn in half and incubated with ethanol as a control (A), or with 20E at a final concentration of 10−8 M (B). The induction of glue proteins in the salivary glands was detected by the expression of a GFP-tagged Sgs3 gene (glueGRN). Note that the posit... |
PMC2413497_pgen-1000102-g001_24040.jpg | What is the core subject represented in this visual? | Glue Genes are Induced by 20E in Cultured Glands.Mid-L3 animals were torn in half and incubated with ethanol as a control (A), or with 20E at a final concentration of 10−8 M (B). The induction of glue proteins in the salivary glands was detected by the expression of a GFP-tagged Sgs3 gene (glueGRN). Note that the posit... |
PMC2413497_pgen-1000102-g002_24034.jpg | What object or scene is depicted here? | sgGal4, a GawB-Derived Driver, Has an Expression Pattern Restricted to the Larval Salivary Glands.Flies containing sgGal4 were crossed to a GFP responder (UAS-GFP.nls) and all developmental stages were examined for the localization of GFP in the nuclei of live animals. The only tissues that contained green protein were... |
PMC2413497_pgen-1000102-g002_24032.jpg | What can you see in this picture? | sgGal4, a GawB-Derived Driver, Has an Expression Pattern Restricted to the Larval Salivary Glands.Flies containing sgGal4 were crossed to a GFP responder (UAS-GFP.nls) and all developmental stages were examined for the localization of GFP in the nuclei of live animals. The only tissues that contained green protein were... |
PMC2413497_pgen-1000102-g002_24033.jpg | What is the core subject represented in this visual? | sgGal4, a GawB-Derived Driver, Has an Expression Pattern Restricted to the Larval Salivary Glands.Flies containing sgGal4 were crossed to a GFP responder (UAS-GFP.nls) and all developmental stages were examined for the localization of GFP in the nuclei of live animals. The only tissues that contained green protein were... |
PMC2413497_pgen-1000102-g002_24035.jpg | What stands out most in this visual? | sgGal4, a GawB-Derived Driver, Has an Expression Pattern Restricted to the Larval Salivary Glands.Flies containing sgGal4 were crossed to a GFP responder (UAS-GFP.nls) and all developmental stages were examined for the localization of GFP in the nuclei of live animals. The only tissues that contained green protein were... |
PMC2413497_pgen-1000102-g003_24039.jpg | What can you see in this picture? | 20E-Mediated glueRED Induction Requires Functional EcR.Confocal images of salivary glands from stocks containing sgGal4; GFP.nls; glueRED transgenes are presented. Normally glueRED is synthesized during the mid-L3 stage and loaded into large granules that remain within the cell until 6–8 hours prior to pupariation (A).... |
PMC2413497_pgen-1000102-g003_24038.jpg | Can you identify the primary element in this image? | 20E-Mediated glueRED Induction Requires Functional EcR.Confocal images of salivary glands from stocks containing sgGal4; GFP.nls; glueRED transgenes are presented. Normally glueRED is synthesized during the mid-L3 stage and loaded into large granules that remain within the cell until 6–8 hours prior to pupariation (A).... |
PMC2413497_pgen-1000102-g003_24036.jpg | What object or scene is depicted here? | 20E-Mediated glueRED Induction Requires Functional EcR.Confocal images of salivary glands from stocks containing sgGal4; GFP.nls; glueRED transgenes are presented. Normally glueRED is synthesized during the mid-L3 stage and loaded into large granules that remain within the cell until 6–8 hours prior to pupariation (A).... |
PMC2413497_pgen-1000102-g003_24037.jpg | What is the principal component of this image? | 20E-Mediated glueRED Induction Requires Functional EcR.Confocal images of salivary glands from stocks containing sgGal4; GFP.nls; glueRED transgenes are presented. Normally glueRED is synthesized during the mid-L3 stage and loaded into large granules that remain within the cell until 6–8 hours prior to pupariation (A).... |
PMC2413497_pgen-1000102-g006_24048.jpg | What is shown in this image? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2413497_pgen-1000102-g006_24045.jpg | What is being portrayed in this visual content? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2413497_pgen-1000102-g006_24049.jpg | What is the central feature of this picture? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2413497_pgen-1000102-g006_24047.jpg | What is the main focus of this visual representation? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2413497_pgen-1000102-g006_24042.jpg | What's the most prominent thing you notice in this picture? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2413497_pgen-1000102-g006_24043.jpg | What is the central feature of this picture? | Silencing USP in the Salivary Gland Does Not Block glueRED Synthesis.Confocal images of salivary glands in which RNAi against USP is triggered demonstrate that glueRED synthesis is normal but not secreted at the time of puparium formation (A). Overexpressing a wildtype USP transgene (USP+) produces a synthesis-defectiv... |
PMC2414658_F1_24051.jpg | What object or scene is depicted here? | Digital images of perforated 5 cm ovine allografts; (A) proximal and (B) distal perforated end plates illustrate the pattern of 16 conduits that extend 10 mm parallel to the long axis of the allograft; (C) contact radiograph of perforated graft indicating consistency of conduit depth. |
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