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PMC2409777_fig1_23782.jpg | What object or scene is depicted here? | Occurrence of nuclear proTGFα in human and rat hepatocarcinogenesis. (A–C) Rat liver 12 months post-NNM: serial sections of a preneoplastic lesion stained for GSTp (A) and TGFα (B); (C) HCC with proTGFα-pos nuclei (C). (D) Preneoplastic GSTp+ hepatocytes (violet) with proTGFα-pos nucleus (brown) and incorporated 3H-thy... |
PMC2409777_fig1_23787.jpg | What is the principal component of this image? | Occurrence of nuclear proTGFα in human and rat hepatocarcinogenesis. (A–C) Rat liver 12 months post-NNM: serial sections of a preneoplastic lesion stained for GSTp (A) and TGFα (B); (C) HCC with proTGFα-pos nuclei (C). (D) Preneoplastic GSTp+ hepatocytes (violet) with proTGFα-pos nucleus (brown) and incorporated 3H-thy... |
PMC2409777_fig1_23786.jpg | What is shown in this image? | Occurrence of nuclear proTGFα in human and rat hepatocarcinogenesis. (A–C) Rat liver 12 months post-NNM: serial sections of a preneoplastic lesion stained for GSTp (A) and TGFα (B); (C) HCC with proTGFα-pos nuclei (C). (D) Preneoplastic GSTp+ hepatocytes (violet) with proTGFα-pos nucleus (brown) and incorporated 3H-thy... |
PMC2409789_fig2_23788.jpg | What stands out most in this visual? | Expression of MUC1 in pancreatic cancer cell lines. Representative pictures are shown for immmunostaining with MAbs C595 (test) and A2 (control). MAb C595 was strongly positive in three cell lines (A–C), while MAb A2 was negative in three cancer cell lines (D–F). Brown staining indicates positive cells. The MUC1 cell s... |
PMC2409789_fig2_23790.jpg | What does this image primarily show? | Expression of MUC1 in pancreatic cancer cell lines. Representative pictures are shown for immmunostaining with MAbs C595 (test) and A2 (control). MAb C595 was strongly positive in three cell lines (A–C), while MAb A2 was negative in three cancer cell lines (D–F). Brown staining indicates positive cells. The MUC1 cell s... |
PMC2409789_fig2_23794.jpg | What's the most prominent thing you notice in this picture? | Expression of MUC1 in pancreatic cancer cell lines. Representative pictures are shown for immmunostaining with MAbs C595 (test) and A2 (control). MAb C595 was strongly positive in three cell lines (A–C), while MAb A2 was negative in three cancer cell lines (D–F). Brown staining indicates positive cells. The MUC1 cell s... |
PMC2409789_fig2_23798.jpg | What is the focal point of this photograph? | Expression of MUC1 in pancreatic cancer cell lines. Representative pictures are shown for immmunostaining with MAbs C595 (test) and A2 (control). MAb C595 was strongly positive in three cell lines (A–C), while MAb A2 was negative in three cancer cell lines (D–F). Brown staining indicates positive cells. The MUC1 cell s... |
PMC2409789_fig2_23799.jpg | What does this image primarily show? | Expression of MUC1 in pancreatic cancer cell lines. Representative pictures are shown for immmunostaining with MAbs C595 (test) and A2 (control). MAb C595 was strongly positive in three cell lines (A–C), while MAb A2 was negative in three cancer cell lines (D–F). Brown staining indicates positive cells. The MUC1 cell s... |
PMC2409799_fig6_23802.jpg | What is the dominant medical problem in this image? | Effects of MI-D on F-actin cytoskeleton organisation of MEL-85 cells. (A) Micrographs of MEL-85 control cells (× 600). (B) MEL-85 control cells at a higher magnification showing details of well-organised F-actin cytoskeleton (× 1450). (C) Micrographs of MEL-85 cells treated with 50 μM MI-D (× 600). (D) MEL-85 treated w... |
PMC2409799_fig6_23800.jpg | What is the principal component of this image? | Effects of MI-D on F-actin cytoskeleton organisation of MEL-85 cells. (A) Micrographs of MEL-85 control cells (× 600). (B) MEL-85 control cells at a higher magnification showing details of well-organised F-actin cytoskeleton (× 1450). (C) Micrographs of MEL-85 cells treated with 50 μM MI-D (× 600). (D) MEL-85 treated w... |
PMC2409801_fig6_23808.jpg | Can you identify the primary element in this image? | (A) Reverse transcriptase PCR analysis of DAC activation on KB-CP1 cells. The cell lines used in this study were described in Figure 1. Measurement of radioactivity in cells is described in Materials and methods. (B) Confocal microscopic immunofluorescent images of FBP stained by a monoclonal antibody specific to human... |
PMC2409801_fig6_23806.jpg | What is the core subject represented in this visual? | (A) Reverse transcriptase PCR analysis of DAC activation on KB-CP1 cells. The cell lines used in this study were described in Figure 1. Measurement of radioactivity in cells is described in Materials and methods. (B) Confocal microscopic immunofluorescent images of FBP stained by a monoclonal antibody specific to human... |
PMC2409801_fig6_23804.jpg | What is shown in this image? | (A) Reverse transcriptase PCR analysis of DAC activation on KB-CP1 cells. The cell lines used in this study were described in Figure 1. Measurement of radioactivity in cells is described in Materials and methods. (B) Confocal microscopic immunofluorescent images of FBP stained by a monoclonal antibody specific to human... |
PMC2409801_fig6_23807.jpg | Can you identify the primary element in this image? | (A) Reverse transcriptase PCR analysis of DAC activation on KB-CP1 cells. The cell lines used in this study were described in Figure 1. Measurement of radioactivity in cells is described in Materials and methods. (B) Confocal microscopic immunofluorescent images of FBP stained by a monoclonal antibody specific to human... |
PMC2409809_fig1_23810.jpg | What does this image primarily show? | Findings in the presented case. (A) Colonoscopy. The tumour was relatively low and flat, with shallow central depression. (B) Magnified view of previous barium enema radiograph obtained 1 year previously. A small pool of barium 4 mm in diameter was present in the left portion of the transverse colon (arrow). (C) Low-po... |
PMC2409809_fig1_23811.jpg | What is the core subject represented in this visual? | Findings in the presented case. (A) Colonoscopy. The tumour was relatively low and flat, with shallow central depression. (B) Magnified view of previous barium enema radiograph obtained 1 year previously. A small pool of barium 4 mm in diameter was present in the left portion of the transverse colon (arrow). (C) Low-po... |
PMC2409809_fig1_23809.jpg | What stands out most in this visual? | Findings in the presented case. (A) Colonoscopy. The tumour was relatively low and flat, with shallow central depression. (B) Magnified view of previous barium enema radiograph obtained 1 year previously. A small pool of barium 4 mm in diameter was present in the left portion of the transverse colon (arrow). (C) Low-po... |
PMC2409837_fig1_23812.jpg | What is the central feature of this picture? | Detection of numerical chromosomal anomalies in pleural effusion cells from a patient with advanced non-small-cell lung cancer. Within a dense reactive cellular background, at least four tumour cells with marked aneuploidy can be recognised. A tumour cell with six copies of chromosome 11 (green) and four copies of chro... |
PMC2409845_fig4_23815.jpg | What is the focal point of this photograph? | Immunofluorescence double staining of a high-grade DCIS with mAb anti-Vn ((A) red signal) and anti-collagen type-4 ((B) green signal); (C) both immunoreactions are associated within the bm of the breast duct and of a blood vessel; (D) DCIS double immunolabelled for Vn and collagen type-4 with a 10-pixel shift of the re... |
PMC2409845_fig4_23814.jpg | Can you identify the primary element in this image? | Immunofluorescence double staining of a high-grade DCIS with mAb anti-Vn ((A) red signal) and anti-collagen type-4 ((B) green signal); (C) both immunoreactions are associated within the bm of the breast duct and of a blood vessel; (D) DCIS double immunolabelled for Vn and collagen type-4 with a 10-pixel shift of the re... |
PMC2409845_fig4_23813.jpg | What object or scene is depicted here? | Immunofluorescence double staining of a high-grade DCIS with mAb anti-Vn ((A) red signal) and anti-collagen type-4 ((B) green signal); (C) both immunoreactions are associated within the bm of the breast duct and of a blood vessel; (D) DCIS double immunolabelled for Vn and collagen type-4 with a 10-pixel shift of the re... |
PMC2409848_fig1_23821.jpg | What stands out most in this visual? | Alveolar soft part sarcoma in an 8-year-old girl. (A) Palate viewed immediately before the first IPDT. A retractor (dark arrows) was applied to the upper lip (UL) exposing the bulky tumour that occupied the whole hard palate with extension to the soft palate and the right palatine tonsil. Black shields (B) were used to... |
PMC2409848_fig2_23818.jpg | What can you see in this picture? | Magnetic resonance images of a maxillary cancer in a 76-year-old man with recurrent episodes of massive nasal bleeding requiring transfusion. (A) T2-weighted MRI before IPDT, showing a tumour in the right maxillary antrum and periorbital invasion. (B) T1-weighted MRI during treatment showing the position of the MR comp... |
PMC2409848_fig2_23819.jpg | What object or scene is depicted here? | Magnetic resonance images of a maxillary cancer in a 76-year-old man with recurrent episodes of massive nasal bleeding requiring transfusion. (A) T2-weighted MRI before IPDT, showing a tumour in the right maxillary antrum and periorbital invasion. (B) T1-weighted MRI during treatment showing the position of the MR comp... |
PMC2409848_fig2_23817.jpg | What stands out most in this visual? | Magnetic resonance images of a maxillary cancer in a 76-year-old man with recurrent episodes of massive nasal bleeding requiring transfusion. (A) T2-weighted MRI before IPDT, showing a tumour in the right maxillary antrum and periorbital invasion. (B) T1-weighted MRI during treatment showing the position of the MR comp... |
PMC2409854_fig1_23824.jpg | What object or scene is depicted here? | Representative immunohistochemical staining patterns for ET-1 (A), ETAR (B) and ETBR (C) in breast carcinomas. For each marker, a sample with weak (left), moderate (middle), and strong (right) cytoplasmic immunostaining is shown. |
PMC2409858_fig1_23823.jpg | What is being portrayed in this visual content? | Immunohistochemical labelling results with anti-EGFR-1 antibody-1. (A) Heterogeneous plasma membrane expression for EGFR-1 in tumour cells. (B) Strong and homogeneous plasma membrane expression for EGFR-1 in tumour cells. |
PMC2409876_fig2_23828.jpg | What's the most prominent thing you notice in this picture? | FDG PET (maximum intensity projection – MIP-image) showing no area of increased uptake. PET transaxial image shows no left lung increased uptake; corresponding transaxial CT image shows an equivocal subpleural area of consolidation in the left lower lobe. After lobectomy, this finding turned out to be benign (fibrosis ... |
PMC2409876_fig2_23829.jpg | What is shown in this image? | FDG PET (maximum intensity projection – MIP-image) showing no area of increased uptake. PET transaxial image shows no left lung increased uptake; corresponding transaxial CT image shows an equivocal subpleural area of consolidation in the left lower lobe. After lobectomy, this finding turned out to be benign (fibrosis ... |
PMC2409876_fig2_23827.jpg | What stands out most in this visual? | FDG PET (maximum intensity projection – MIP-image) showing no area of increased uptake. PET transaxial image shows no left lung increased uptake; corresponding transaxial CT image shows an equivocal subpleural area of consolidation in the left lower lobe. After lobectomy, this finding turned out to be benign (fibrosis ... |
PMC2409876_fig3_23830.jpg | What does this image primarily show? | FDG PET (maximum intensity projection – MIP-image) showing an area of increased uptake in a left latero-crevical lymph node and a second area of increased uptake in abdomen, likely consistent with juxtaintestinal lymph node. Corresponding transaxial PET and CT images show the enlarged left laterocervical lymph node. Bi... |
PMC2409876_fig3_23831.jpg | What is the principal component of this image? | FDG PET (maximum intensity projection – MIP-image) showing an area of increased uptake in a left latero-crevical lymph node and a second area of increased uptake in abdomen, likely consistent with juxtaintestinal lymph node. Corresponding transaxial PET and CT images show the enlarged left laterocervical lymph node. Bi... |
PMC2409876_fig3_23832.jpg | What stands out most in this visual? | FDG PET (maximum intensity projection – MIP-image) showing an area of increased uptake in a left latero-crevical lymph node and a second area of increased uptake in abdomen, likely consistent with juxtaintestinal lymph node. Corresponding transaxial PET and CT images show the enlarged left laterocervical lymph node. Bi... |
PMC2409904_fig2_23834.jpg | Describe the main subject of this image. | (A–C) Gastric carcinoma of the G-phenotype. (A) Histological features (H&E, original magnification × 400). (B) Human gastric mucin is expressed in the cancer cell cytoplasm (45M1, original magnification × 400). (C) MUC6 glycoprotein is also expressed in the cancer cell cytoplasm (CLH5, original magnification × 400). |
PMC2409904_fig2_23835.jpg | What's the most prominent thing you notice in this picture? | (A–C) Gastric carcinoma of the G-phenotype. (A) Histological features (H&E, original magnification × 400). (B) Human gastric mucin is expressed in the cancer cell cytoplasm (45M1, original magnification × 400). (C) MUC6 glycoprotein is also expressed in the cancer cell cytoplasm (CLH5, original magnification × 400). |
PMC2409904_fig3_23837.jpg | What's the most prominent thing you notice in this picture? | (A–C) Gastric carcinoma of the I-phenotype. Histological features (H&E, original magnification × 200). (B) MUC2 glycoprotein is expressed in the cancer cell cytoplasm (Ccp58, original magnification × 200). (C) CD10 glycoprotein is also expressed on the luminal surfaces of cancerous glands (56C6, original magnification ... |
PMC2409904_fig3_23838.jpg | What is the main focus of this visual representation? | (A–C) Gastric carcinoma of the I-phenotype. Histological features (H&E, original magnification × 200). (B) MUC2 glycoprotein is expressed in the cancer cell cytoplasm (Ccp58, original magnification × 200). (C) CD10 glycoprotein is also expressed on the luminal surfaces of cancerous glands (56C6, original magnification ... |
PMC2409918_fig3_23839.jpg | What is shown in this image? | Appearance of a CF on a confocal microscope. RL cells were incubated overnight with Alexa 488-1F5; a large CF attached to a cell is shown. (A) The pinhole size was 20, giving a slice thickness (FWHM) of 1.5 μm. (B) The pinhole size was 50, giving a slice thickness of 3.6 μm, and the laser power was increased to allow c... |
PMC2409918_fig5_23841.jpg | What's the most prominent thing you notice in this picture? | Fluorescence of RL cells after overnight incubation with Alexa 488-1F5. Cells were examined without washing away unbound Ab, and were handled as gently as possible, to leave cell clusters intact. (A) Fluorescence. (B) Dim visible light (using phase contrast) together with fluorescence, showing the same cells. Fluoresce... |
PMC2409918_fig5_23842.jpg | What's the most prominent thing you notice in this picture? | Fluorescence of RL cells after overnight incubation with Alexa 488-1F5. Cells were examined without washing away unbound Ab, and were handled as gently as possible, to leave cell clusters intact. (A) Fluorescence. (B) Dim visible light (using phase contrast) together with fluorescence, showing the same cells. Fluoresce... |
PMC2409937_fig5_23843.jpg | What stands out most in this visual? | Anti-PDXP-stained cytoplasm of microglia of human brain sections in immunohistochemical experiments (400 ×). Examples of stained cells are marked with *. |
PMC2409949_fig1_23844.jpg | What stands out most in this visual? | Immunohistochemical examination of FAP-1, FasR and FasL expression and TUNEL staining in human colon adenocarcinomas. Antibodies were detected using a DAB method that produces a brown colour. Counterstaining of nuclei with haematoxylin (blue). (A) FAP-1-positive immunohistochemical staining in the cytoplasm of colon ad... |
PMC2409949_fig1_23846.jpg | What can you see in this picture? | Immunohistochemical examination of FAP-1, FasR and FasL expression and TUNEL staining in human colon adenocarcinomas. Antibodies were detected using a DAB method that produces a brown colour. Counterstaining of nuclei with haematoxylin (blue). (A) FAP-1-positive immunohistochemical staining in the cytoplasm of colon ad... |
PMC2409956_fig2_23849.jpg | What's the most prominent thing you notice in this picture? | Morphological effects of khat in HL60 cells. HL-60 cells in early logarithmic growth phase were exposed to an organic extract of khat (200 μg ml−1) for 8 h (panels B and D) or left nonsupplemented (control treated with DMSO solvent) (panels A and C). The cellular morphology was visualised by electron microscopy at × 10... |
PMC2409956_fig2_23848.jpg | What object or scene is depicted here? | Morphological effects of khat in HL60 cells. HL-60 cells in early logarithmic growth phase were exposed to an organic extract of khat (200 μg ml−1) for 8 h (panels B and D) or left nonsupplemented (control treated with DMSO solvent) (panels A and C). The cellular morphology was visualised by electron microscopy at × 10... |
PMC2409956_fig2_23851.jpg | What is being portrayed in this visual content? | Morphological effects of khat in HL60 cells. HL-60 cells in early logarithmic growth phase were exposed to an organic extract of khat (200 μg ml−1) for 8 h (panels B and D) or left nonsupplemented (control treated with DMSO solvent) (panels A and C). The cellular morphology was visualised by electron microscopy at × 10... |
PMC2409976_pone-0002420-g007_23857.jpg | What is the dominant medical problem in this image? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23860.jpg | What is the main focus of this visual representation? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23861.jpg | What is the central feature of this picture? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23856.jpg | Can you identify the primary element in this image? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23855.jpg | Can you identify the primary element in this image? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23858.jpg | What is the dominant medical problem in this image? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23862.jpg | What is the dominant medical problem in this image? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2409976_pone-0002420-g007_23852.jpg | What stands out most in this visual? | Zonating morphogenesis affected by miR-328 targeting CD44 in nude mice.(A) Tumors formed by injection of cells transfected with GFP or miR-328 were sectioned, immunostained for CD44, and photographed at 10x, 20x, and 40x magnifications. As a negative control, section was stained with secondary antibody alone. In the mi... |
PMC2410047_fig5_23864.jpg | What key item or scene is captured in this photo? | Etoposide-mediated effects on clusterin expression in PNT1a and PC-3 cells. Western blot detection of clusterin expression, cleaved caspase-3 and cleaved PARP in PNT1a (A) and PC-3 (E) cells. Equal protein loading was confirmed by pan-cytokeratin detection. Lanes 1: parental untransfected cells; lanes 2: parental cells... |
PMC2410047_fig5_23868.jpg | What is the dominant medical problem in this image? | Etoposide-mediated effects on clusterin expression in PNT1a and PC-3 cells. Western blot detection of clusterin expression, cleaved caspase-3 and cleaved PARP in PNT1a (A) and PC-3 (E) cells. Equal protein loading was confirmed by pan-cytokeratin detection. Lanes 1: parental untransfected cells; lanes 2: parental cells... |
PMC2410047_fig5_23867.jpg | What object or scene is depicted here? | Etoposide-mediated effects on clusterin expression in PNT1a and PC-3 cells. Western blot detection of clusterin expression, cleaved caspase-3 and cleaved PARP in PNT1a (A) and PC-3 (E) cells. Equal protein loading was confirmed by pan-cytokeratin detection. Lanes 1: parental untransfected cells; lanes 2: parental cells... |
PMC2410047_fig5_23865.jpg | Describe the main subject of this image. | Etoposide-mediated effects on clusterin expression in PNT1a and PC-3 cells. Western blot detection of clusterin expression, cleaved caspase-3 and cleaved PARP in PNT1a (A) and PC-3 (E) cells. Equal protein loading was confirmed by pan-cytokeratin detection. Lanes 1: parental untransfected cells; lanes 2: parental cells... |
PMC2410050_fig4_23871.jpg | What stands out most in this visual? | Serial CT scans of a 69-year-old male with pancreatic cancer who was treated with NK911 at an initial dosage level of 67 mg m−2 during the first course and at 50 mg m−2 after the second course. Changes in tumour marker levels are also shown. (A) Baseline scan showing a metastasis in the left lateral lobe. (B) Partial r... |
PMC2410050_fig4_23872.jpg | What key item or scene is captured in this photo? | Serial CT scans of a 69-year-old male with pancreatic cancer who was treated with NK911 at an initial dosage level of 67 mg m−2 during the first course and at 50 mg m−2 after the second course. Changes in tumour marker levels are also shown. (A) Baseline scan showing a metastasis in the left lateral lobe. (B) Partial r... |
PMC2410120_fig2_23878.jpg | What is the dominant medical problem in this image? | (A–D) Magnetic resonance images of mouse brain with Mel57-VEGF-A165 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D). The imaging parameters are the same as in Figure 1. From the image shown in the figure, three ROIs (labelled a, b and c) were analysed. (E and F) Immunostain... |
PMC2410120_fig2_23876.jpg | What does this image primarily show? | (A–D) Magnetic resonance images of mouse brain with Mel57-VEGF-A165 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D). The imaging parameters are the same as in Figure 1. From the image shown in the figure, three ROIs (labelled a, b and c) were analysed. (E and F) Immunostain... |
PMC2410120_fig2_23874.jpg | What can you see in this picture? | (A–D) Magnetic resonance images of mouse brain with Mel57-VEGF-A165 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D). The imaging parameters are the same as in Figure 1. From the image shown in the figure, three ROIs (labelled a, b and c) were analysed. (E and F) Immunostain... |
PMC2410120_fig3_23880.jpg | What key item or scene is captured in this photo? | (A–D) Magnetic resonance images of mouse brain with a U87 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D), with the same imaging parameters as in Figure 1. (E and F) Immunohistochemical staining for glut-1 (E), highlighting vessels and an immunostaining for extravasated mou... |
PMC2410120_fig3_23881.jpg | Can you identify the primary element in this image? | (A–D) Magnetic resonance images of mouse brain with a U87 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D), with the same imaging parameters as in Figure 1. (E and F) Immunohistochemical staining for glut-1 (E), highlighting vessels and an immunostaining for extravasated mou... |
PMC2410120_fig3_23883.jpg | What object or scene is depicted here? | (A–D) Magnetic resonance images of mouse brain with a U87 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D), with the same imaging parameters as in Figure 1. (E and F) Immunohistochemical staining for glut-1 (E), highlighting vessels and an immunostaining for extravasated mou... |
PMC2410120_fig3_23885.jpg | Can you identify the primary element in this image? | (A–D) Magnetic resonance images of mouse brain with a U87 tumour, acquired prior to (A and C) and following administration of Gd-DTPA (B) and USPIO (D), with the same imaging parameters as in Figure 1. (E and F) Immunohistochemical staining for glut-1 (E), highlighting vessels and an immunostaining for extravasated mou... |
PMC2410152_fig1_23886.jpg | What is the main focus of this visual representation? | Immunohistochemical detection after the development of AIPC of (A) c-erbB-1 (magnification × 40) and (B) c-erbB-2 (magnification × 20). |
PMC2410152_fig1_23887.jpg | What stands out most in this visual? | Immunohistochemical detection after the development of AIPC of (A) c-erbB-1 (magnification × 40) and (B) c-erbB-2 (magnification × 20). |
PMC2410155_fig3_23906.jpg | Describe the main subject of this image. | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23911.jpg | What stands out most in this visual? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23910.jpg | What is the main focus of this visual representation? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23904.jpg | What key item or scene is captured in this photo? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23901.jpg | What is the principal component of this image? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23909.jpg | What is the principal component of this image? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23900.jpg | What stands out most in this visual? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23907.jpg | What does this image primarily show? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23908.jpg | What's the most prominent thing you notice in this picture? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig3_23902.jpg | What is the focal point of this photograph? | Immunohistochemical analysis of gastric tumours. Representative images of tumour sections stained with haematoxylin and eosin (row 1; × 200 magnification), stained immunohistochemically for CD31 (row 2; × 200) or for PCNA (row 3; × 200), or stained for apoptosis by TUNEL (row 4, × 200). Weekly ZD6126 caused a significa... |
PMC2410155_fig4_23888.jpg | Can you identify the primary element in this image? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23899.jpg | What is the principal component of this image? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23895.jpg | What is the core subject represented in this visual? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23891.jpg | What is the focal point of this photograph? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23889.jpg | What is being portrayed in this visual content? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23898.jpg | What is shown in this image? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23894.jpg | What is the core subject represented in this visual? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23896.jpg | What does this image primarily show? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23897.jpg | What does this image primarily show? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410155_fig4_23890.jpg | What is the central feature of this picture? | Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell ap... |
PMC2410158_fig1_23912.jpg | What object or scene is depicted here? | Example of histopathological examination of breast tumour specimen (invasive ductal carcinome, grade 2, breast cancer sample Eli 8). |
PMC2410163_fig3_23919.jpg | What is the central feature of this picture? | CHEK2 protein expression. Nonmutated squamous cell carcinoma in (A), nonmutated adenocarcinoma in (B). The remaining samples are from the four mutated tumours: adenocarcinomas T1, T2 and T3 shown in (C–E), squamous cell carcinoma T4 shown in (F). Magnification × 100 (B, E), × 50 (A, C, D, F). Note the strong nuclear CH... |
PMC2410163_fig3_23915.jpg | Describe the main subject of this image. | CHEK2 protein expression. Nonmutated squamous cell carcinoma in (A), nonmutated adenocarcinoma in (B). The remaining samples are from the four mutated tumours: adenocarcinomas T1, T2 and T3 shown in (C–E), squamous cell carcinoma T4 shown in (F). Magnification × 100 (B, E), × 50 (A, C, D, F). Note the strong nuclear CH... |
PMC2410163_fig3_23917.jpg | What is the main focus of this visual representation? | CHEK2 protein expression. Nonmutated squamous cell carcinoma in (A), nonmutated adenocarcinoma in (B). The remaining samples are from the four mutated tumours: adenocarcinomas T1, T2 and T3 shown in (C–E), squamous cell carcinoma T4 shown in (F). Magnification × 100 (B, E), × 50 (A, C, D, F). Note the strong nuclear CH... |
PMC2410163_fig3_23918.jpg | Can you identify the primary element in this image? | CHEK2 protein expression. Nonmutated squamous cell carcinoma in (A), nonmutated adenocarcinoma in (B). The remaining samples are from the four mutated tumours: adenocarcinomas T1, T2 and T3 shown in (C–E), squamous cell carcinoma T4 shown in (F). Magnification × 100 (B, E), × 50 (A, C, D, F). Note the strong nuclear CH... |
PMC2410163_fig3_23914.jpg | What is the core subject represented in this visual? | CHEK2 protein expression. Nonmutated squamous cell carcinoma in (A), nonmutated adenocarcinoma in (B). The remaining samples are from the four mutated tumours: adenocarcinomas T1, T2 and T3 shown in (C–E), squamous cell carcinoma T4 shown in (F). Magnification × 100 (B, E), × 50 (A, C, D, F). Note the strong nuclear CH... |
PMC2410164_fig4_23921.jpg | What is the dominant medical problem in this image? | (A) Regressing dermal metastases with perilesional vitiligo in patient 4. (B) Melanin-laden melanophages in upper dermis, in a skin biopsy from a regressing lesion of patient 4 (H&E × 20). (C) White hair arising from regressed s.c. metastases. Hair of noninvolved skin is fully melanised (patient 11). |
PMC2410164_fig4_23922.jpg | What is the core subject represented in this visual? | (A) Regressing dermal metastases with perilesional vitiligo in patient 4. (B) Melanin-laden melanophages in upper dermis, in a skin biopsy from a regressing lesion of patient 4 (H&E × 20). (C) White hair arising from regressed s.c. metastases. Hair of noninvolved skin is fully melanised (patient 11). |
PMC2410174_fig1_23926.jpg | What is the main focus of this visual representation? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23932.jpg | What stands out most in this visual? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
PMC2410174_fig1_23929.jpg | What key item or scene is captured in this photo? | A series of images from patient #5 demonstrating the reduction in tumour volume apparent on FLAIR (top) and T2W-FSE (bottom) images. Images displayed are from (A) pretreatment and post-treatment at (B) 3 months, (C) 6 months, (D) 9 months and (E) 12 months. Note the visible reduction in abnormal signal intensity on the... |
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