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PMC1890305_pone-0000546-g002_11508.jpg | What stands out most in this visual? | Neural Interaction of Emotion and Feedback Veracity.Left; Significant interactions of emotion (happy neutral) and feedback (true false) were observed on neural activity within; 1) right anterior insula, 2) right amygdala, 3)left amygdala, 4)right mid insula, 5) left mid insula and 6) posterior dorsal cerebellum. Functional interactions are projected onto a normalised mean structural image calculated from each individual subjects structural T1 weighted image. Dashed bounding box illustrates volume of acquired T2 data. Right; Contrast estimates at the illustrated regions are displayed. |
PMC1890305_pone-0000546-g002_11510.jpg | What is the dominant medical problem in this image? | Neural Interaction of Emotion and Feedback Veracity.Left; Significant interactions of emotion (happy neutral) and feedback (true false) were observed on neural activity within; 1) right anterior insula, 2) right amygdala, 3)left amygdala, 4)right mid insula, 5) left mid insula and 6) posterior dorsal cerebellum. Functional interactions are projected onto a normalised mean structural image calculated from each individual subjects structural T1 weighted image. Dashed bounding box illustrates volume of acquired T2 data. Right; Contrast estimates at the illustrated regions are displayed. |
PMC1890305_pone-0000546-g004_11518.jpg | What is the main focus of this visual representation? | Interaction of Emotion and Feedback Veracity within Right Anterior Insula.Within the Right Anterior Insula, a significant interaction of emotion (happy neutral) and feedback (true false) was observed when considering both exercise and non-exercise conditions. This interaction closely resembles the right anterior insula interaction previously observed within the non-exercise condition alone. A) Coronal and sagittal sections, B) Contrast estimates. C) When considering both the exercise and non-exercise conditions, individual subjects' ratings of neutral faces during false is significantly correlated with BOLD responses within the right anterior insula cortex (across subjects). |
PMC1890305_pone-0000546-g004_11516.jpg | What is the focal point of this photograph? | Interaction of Emotion and Feedback Veracity within Right Anterior Insula.Within the Right Anterior Insula, a significant interaction of emotion (happy neutral) and feedback (true false) was observed when considering both exercise and non-exercise conditions. This interaction closely resembles the right anterior insula interaction previously observed within the non-exercise condition alone. A) Coronal and sagittal sections, B) Contrast estimates. C) When considering both the exercise and non-exercise conditions, individual subjects' ratings of neutral faces during false is significantly correlated with BOLD responses within the right anterior insula cortex (across subjects). |
PMC1890305_pone-0000546-g005_11520.jpg | What is shown in this image? | Right anterior insula and subjective ratings (within subject).Parametric modulation analysis of BOLD activity within right anterior insula by attributed intensity of neutral faces during false feedback were conducted within each subject. Second level group analysis of within subject results revealed a significant association within right anterior insula. Left: An individual subjects activation overlaid on their structural T1 weighted image. Right: Within the right anterior insula, the HRF amplitude is modulated as a function of the perceived intensity of neutral faces during false physiological feedback. The predicted response is illustrated across the entire HRF (right top) and at the peak HRF response (right bottom). |
PMC1890305_pone-0000546-g005_11519.jpg | Can you identify the primary element in this image? | Right anterior insula and subjective ratings (within subject).Parametric modulation analysis of BOLD activity within right anterior insula by attributed intensity of neutral faces during false feedback were conducted within each subject. Second level group analysis of within subject results revealed a significant association within right anterior insula. Left: An individual subjects activation overlaid on their structural T1 weighted image. Right: Within the right anterior insula, the HRF amplitude is modulated as a function of the perceived intensity of neutral faces during false physiological feedback. The predicted response is illustrated across the entire HRF (right top) and at the peak HRF response (right bottom). |
PMC1890580_fig04_11523.jpg | What does this image primarily show? | The CB1 receptor agonist arachidonylcyclopropylamide (ACPA) reduces the calcium transient in the motor nerve terminal triggered by a single nerve impulse. (A) Low magnification image of a preparation loaded with calcium green-1 dextran. The dye has been loaded into a few axons and made its way into the nerve terminals. Scale bar, 100 µm. (B) An overlay of the calcium green-1 dextran fluorescence emission onto an image collected using differential-interference contrast (Nomarski) optics. Both images were taken with a 60× water immersion objective (numerical aperture 1.0) and a Coolsnap camera (Photometrics). Scale bar, 10 µm. (C) Fluorescence emission intensity is plotted in arbitrary units as a function of time relative to the stimulus pulse used to elicit an action potential in the motor nerve. Three traces obtained during the perfusion with normal physiological saline (Control), following the application of 5 µm ACPA for 5 min (ACPA) and following the wash-out of ACPA with normal saline for 20 min (Wash). (D) Mean amplitudes of the calcium transients measured under the three conditions: Control (n = 12), ACPA (n = 12) and Wash (n = 9). The application of 10 µm ACPA results in a significant (*P < 0.05 Student's t-test) and reversible decrease in the calcium transients induced by a single action potential in the motor nerve. |
PMC1890580_fig04_11524.jpg | What is the focal point of this photograph? | The CB1 receptor agonist arachidonylcyclopropylamide (ACPA) reduces the calcium transient in the motor nerve terminal triggered by a single nerve impulse. (A) Low magnification image of a preparation loaded with calcium green-1 dextran. The dye has been loaded into a few axons and made its way into the nerve terminals. Scale bar, 100 µm. (B) An overlay of the calcium green-1 dextran fluorescence emission onto an image collected using differential-interference contrast (Nomarski) optics. Both images were taken with a 60× water immersion objective (numerical aperture 1.0) and a Coolsnap camera (Photometrics). Scale bar, 10 µm. (C) Fluorescence emission intensity is plotted in arbitrary units as a function of time relative to the stimulus pulse used to elicit an action potential in the motor nerve. Three traces obtained during the perfusion with normal physiological saline (Control), following the application of 5 µm ACPA for 5 min (ACPA) and following the wash-out of ACPA with normal saline for 20 min (Wash). (D) Mean amplitudes of the calcium transients measured under the three conditions: Control (n = 12), ACPA (n = 12) and Wash (n = 9). The application of 10 µm ACPA results in a significant (*P < 0.05 Student's t-test) and reversible decrease in the calcium transients induced by a single action potential in the motor nerve. |
PMC1890920_fig03_11533.jpg | What is being portrayed in this visual content? | Two examples of squamous lesions signed out as atypical immature metaplasia. A cervical biopsy specimen of a 32-year-old woman (a–c) revealing a flat squamous lesion several cell layers thick with disorderly stratification and nuclear enlargement (a). In step sections, the dysplastic features become more prominent and p16 stains strongly positive (b), while cytokeratin (CK) 17 is largely negative (c). Another cervical biospy of a 40-year-old woman (d–f) shows a squamous lesion involving an endocervical gland. p63 highlights the nuclei of basal and suprabasal cells (d), while p16 (e) shows strong uniform positivity of the entire stratified epithelium and CK17 stains the basal proliferating cells (f). |
PMC1890920_fig03_11530.jpg | What is the main focus of this visual representation? | Two examples of squamous lesions signed out as atypical immature metaplasia. A cervical biopsy specimen of a 32-year-old woman (a–c) revealing a flat squamous lesion several cell layers thick with disorderly stratification and nuclear enlargement (a). In step sections, the dysplastic features become more prominent and p16 stains strongly positive (b), while cytokeratin (CK) 17 is largely negative (c). Another cervical biospy of a 40-year-old woman (d–f) shows a squamous lesion involving an endocervical gland. p63 highlights the nuclei of basal and suprabasal cells (d), while p16 (e) shows strong uniform positivity of the entire stratified epithelium and CK17 stains the basal proliferating cells (f). |
PMC1890920_fig03_11531.jpg | What is the principal component of this image? | Two examples of squamous lesions signed out as atypical immature metaplasia. A cervical biopsy specimen of a 32-year-old woman (a–c) revealing a flat squamous lesion several cell layers thick with disorderly stratification and nuclear enlargement (a). In step sections, the dysplastic features become more prominent and p16 stains strongly positive (b), while cytokeratin (CK) 17 is largely negative (c). Another cervical biospy of a 40-year-old woman (d–f) shows a squamous lesion involving an endocervical gland. p63 highlights the nuclei of basal and suprabasal cells (d), while p16 (e) shows strong uniform positivity of the entire stratified epithelium and CK17 stains the basal proliferating cells (f). |
PMC1891001_fig01_11528.jpg | What is the main focus of this visual representation? | Immunohistochemical reactivity for CD31 in human hepatocellular carcinoma (HCC). Note in (A) focal reactivity of a few sinusoids in normal liver; in (B) a moderate increase in cirrhotic liver and in (C) strong immunoreactivity in a poorly differentiated HCC. |
PMC1891001_fig01_11529.jpg | What is shown in this image? | Immunohistochemical reactivity for CD31 in human hepatocellular carcinoma (HCC). Note in (A) focal reactivity of a few sinusoids in normal liver; in (B) a moderate increase in cirrhotic liver and in (C) strong immunoreactivity in a poorly differentiated HCC. |
PMC1891001_fig02_11538.jpg | What's the most prominent thing you notice in this picture? | Immunohistochemical reactivity for erythropoietin (Epo) and erythropoietin receptor (EpoR) in human hepatocellular carcinoma (HCC). Note in (A) strong immunoreactivity for EpoR in sinusoidal endothelial cells in a poorly differentiated HCC; in (B) membrane-linear/cytoplasmic staining for EpoR in tumour cells of a poorly differentiated HCC; in (C) absence of staining for EpoR in cirrhotic cells; in (D) weak and cytoplasmic granular staining for Epo in tumour cells of a poorly differentiated HCC; in (E) absence of staining for Epo in cirrhotic cells. |
PMC1891001_fig02_11539.jpg | What is the main focus of this visual representation? | Immunohistochemical reactivity for erythropoietin (Epo) and erythropoietin receptor (EpoR) in human hepatocellular carcinoma (HCC). Note in (A) strong immunoreactivity for EpoR in sinusoidal endothelial cells in a poorly differentiated HCC; in (B) membrane-linear/cytoplasmic staining for EpoR in tumour cells of a poorly differentiated HCC; in (C) absence of staining for EpoR in cirrhotic cells; in (D) weak and cytoplasmic granular staining for Epo in tumour cells of a poorly differentiated HCC; in (E) absence of staining for Epo in cirrhotic cells. |
PMC1891001_fig02_11537.jpg | What object or scene is depicted here? | Immunohistochemical reactivity for erythropoietin (Epo) and erythropoietin receptor (EpoR) in human hepatocellular carcinoma (HCC). Note in (A) strong immunoreactivity for EpoR in sinusoidal endothelial cells in a poorly differentiated HCC; in (B) membrane-linear/cytoplasmic staining for EpoR in tumour cells of a poorly differentiated HCC; in (C) absence of staining for EpoR in cirrhotic cells; in (D) weak and cytoplasmic granular staining for Epo in tumour cells of a poorly differentiated HCC; in (E) absence of staining for Epo in cirrhotic cells. |
PMC1891001_fig02_11540.jpg | What is the dominant medical problem in this image? | Immunohistochemical reactivity for erythropoietin (Epo) and erythropoietin receptor (EpoR) in human hepatocellular carcinoma (HCC). Note in (A) strong immunoreactivity for EpoR in sinusoidal endothelial cells in a poorly differentiated HCC; in (B) membrane-linear/cytoplasmic staining for EpoR in tumour cells of a poorly differentiated HCC; in (C) absence of staining for EpoR in cirrhotic cells; in (D) weak and cytoplasmic granular staining for Epo in tumour cells of a poorly differentiated HCC; in (E) absence of staining for Epo in cirrhotic cells. |
PMC1891001_fig02_11536.jpg | Describe the main subject of this image. | Immunohistochemical reactivity for erythropoietin (Epo) and erythropoietin receptor (EpoR) in human hepatocellular carcinoma (HCC). Note in (A) strong immunoreactivity for EpoR in sinusoidal endothelial cells in a poorly differentiated HCC; in (B) membrane-linear/cytoplasmic staining for EpoR in tumour cells of a poorly differentiated HCC; in (C) absence of staining for EpoR in cirrhotic cells; in (D) weak and cytoplasmic granular staining for Epo in tumour cells of a poorly differentiated HCC; in (E) absence of staining for Epo in cirrhotic cells. |
PMC1891007_fig01_11541.jpg | What is shown in this image? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11545.jpg | What key item or scene is captured in this photo? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11551.jpg | What is the focal point of this photograph? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11546.jpg | What can you see in this picture? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11550.jpg | Describe the main subject of this image. | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11549.jpg | What stands out most in this visual? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11544.jpg | Can you identify the primary element in this image? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11547.jpg | What is the central feature of this picture? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11542.jpg | What is the focal point of this photograph? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11552.jpg | What is the main focus of this visual representation? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig01_11548.jpg | What is the focal point of this photograph? | Expression of a CD8-CIMPR chimera enhances GGA labelingCells stably expressing CD8-CIMPR were mixed with non-transfected cells, fixed and double labeled with anti-CD8 (B, D, F, H, J and L) and antibodies against various coat proteins (A, C, E, G, I and K, shown above the CD8 images). All three GGAs, as well as their binding partner p56, show enhanced labeling in the CD8-CIMPR-expressing cells; retromer shows no increase in labeling, and AP-1 may show a subtle increase. Scale bar: 10 μm. |
PMC1891007_fig02_11558.jpg | What is shown in this image? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11564.jpg | What stands out most in this visual? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11563.jpg | Describe the main subject of this image. | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11557.jpg | What's the most prominent thing you notice in this picture? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11556.jpg | Describe the main subject of this image. | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11561.jpg | Describe the main subject of this image. | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11562.jpg | Can you identify the primary element in this image? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11567.jpg | Can you identify the primary element in this image? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11553.jpg | What key item or scene is captured in this photo? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11566.jpg | What stands out most in this visual? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11555.jpg | What object or scene is depicted here? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig02_11565.jpg | What is the central feature of this picture? | The DXXLL motif is needed for enhanced GGA labelingCells expressing various CD8 constructs were fixed and double labeled with anti-GGA2 (A, C, E, G, I, K, M and O) and anti-CD8 (B, D, F, H, J, L, N and P). In most of the images, the cells were stably transfected and then mixed with non-transfected cells; however, the cells in (I) and (J) were transiently transfected. Enhanced GGA labeling is only seen in cells expressing constructs with a DXXLL motif in the cytoplasmic tail. Scale bar: 1 μm. |
PMC1891007_fig06_11575.jpg | What is shown in this image? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11574.jpg | What is the core subject represented in this visual? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11576.jpg | What is the core subject represented in this visual? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11573.jpg | What is the central feature of this picture? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11571.jpg | What is the core subject represented in this visual? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11570.jpg | What's the most prominent thing you notice in this picture? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11569.jpg | What stands out most in this visual? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891007_fig06_11572.jpg | What key item or scene is captured in this photo? | Enhanced GGA2 labeling in CD8-CIMPR-expressing cells is partially BFA insensitiveCells stably expressing CD8-CIMPR were mixed with non-transfected cells, treated with or without 20 μg/mL BFA for 10 min, fixed and double labeled for AP-1 and CD8 (A and B, E and F) or GGA2 and CD8 (C and D, G and H). Addition of BFA causes AP-1 to dissociate completely from the membrane, whereas a pool of GGA2 remains associated in the CD8-CIMPR-expressing cells. Scale bar: 10 μm. |
PMC1891098_F1_11577.jpg | What is being portrayed in this visual content? | The [123I]ADAM template (mean image of scans of 15 healthy women) and the midbrain (left) and thalamus (right) volumes of interest. |
PMC1891104_F5_11589.jpg | Can you identify the primary element in this image? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11591.jpg | Can you identify the primary element in this image? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11585.jpg | What is the main focus of this visual representation? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11584.jpg | What is shown in this image? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11587.jpg | What is the principal component of this image? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11592.jpg | What's the most prominent thing you notice in this picture? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11586.jpg | What stands out most in this visual? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11593.jpg | What does this image primarily show? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F5_11588.jpg | What does this image primarily show? | Morphological (A) and histological (B, C and D) studies on fetus from BALB/c mice immunized either with G21V (right) or with CFA (left). Note the difference in size (A2), delayed neuronal folding (A2 & 4), absence of hindbrain (arrow) and open neuronal tube (*) in fetus from mouse with anti-5-HT4 antibodies. Figures 5B 1–6 are the magnifications of figures 5A3 and 4 in order to highlight the abnormalities. Figure 5B1 shows the normal neuronal tube and 5B2 shows the open neuronal tube in control fetus and fetus from mouse with anti-5-HT4 antibodies (NT), axons (Ax) neurons (N). In Figure 5B3 and 5B4 foetal heart tissues, from control (5B3) and from mouse with anti-5-HT4 antibodies (5B4) are shown. Dotted arrow shows size and form abnormalities. Figure 5B5 and 6 show the higher magnification of the heart from control fetus (5B5) and fetus from mouse with anti-5-HT4 antibodies (5B6). The heart from the fetus in right panel is symmetric (5B4) compared to the fetus from the control mouse (5B3), where its heart is asymmetric with distinct and normal formation of apex. Myocardium (M), Pericardium (doted arrow), fibroblast (arrow) |
PMC1891104_F6_11582.jpg | What is the principal component of this image? | (A) Shows in heart decreased fibroblast immunoreactivity in fetus from a mouse with anti-5-HT4 antibodies. Hearts from a control fetus is shown in A (100×) and D (1000×) and from fetus affected by anti-5-HT4 antibody is shown in B (100×) and D (1000×). The presence of immunocomplex between anti-αSMA antibodies and heart tissue is revealed with DAB (orange colour in A and B) and counterstained with hematoxyline (Harris) as it shown in higher magnification in C and D. Figure 6B. Represents the estimated immunoreactivity as measured by densitometry in heart tissues from control fetus and fetus from mouse with anti-5-HT4 antibodies (expressed in absorbance unit/pixel area, AU/px2) |
PMC1891104_F6_11579.jpg | What's the most prominent thing you notice in this picture? | (A) Shows in heart decreased fibroblast immunoreactivity in fetus from a mouse with anti-5-HT4 antibodies. Hearts from a control fetus is shown in A (100×) and D (1000×) and from fetus affected by anti-5-HT4 antibody is shown in B (100×) and D (1000×). The presence of immunocomplex between anti-αSMA antibodies and heart tissue is revealed with DAB (orange colour in A and B) and counterstained with hematoxyline (Harris) as it shown in higher magnification in C and D. Figure 6B. Represents the estimated immunoreactivity as measured by densitometry in heart tissues from control fetus and fetus from mouse with anti-5-HT4 antibodies (expressed in absorbance unit/pixel area, AU/px2) |
PMC1891108_F2_11595.jpg | What is the central feature of this picture? | Microscopy (magnification × 100). Abdominal fluid: A. corymbifera growth in culture with sporangium and cone-shaped columella. |
PMC1891170_f2-co13_2p061_11596.jpg | What stands out most in this visual? | Three-dimensional conformal radiation therapy (3D-crt) treatment plan showing the clinical target volumes ctv66, ctv54, and isodose lines for 66 Gy, 54 Gy, and 35 Gy. |
PMC1891177_f1-co13_3p108_11597.jpg | What is the dominant medical problem in this image? | For this patient, elevation of the shoulder during the repeat computed tomography (ct) scan (right) as compared with the planning ct scan (left) resulted in reduced coverage of the lower neck region because of greater attenuation of the oblique beams. The effect on the prescription isodose (orange) is significant, but influence on the coverage by the 90% isodose (green) is minimal. |
PMC1891177_f1-co13_3p108_11599.jpg | Describe the main subject of this image. | For this patient, elevation of the shoulder during the repeat computed tomography (ct) scan (right) as compared with the planning ct scan (left) resulted in reduced coverage of the lower neck region because of greater attenuation of the oblique beams. The effect on the prescription isodose (orange) is significant, but influence on the coverage by the 90% isodose (green) is minimal. |
PMC1891177_f1-co13_3p108_11598.jpg | What is the core subject represented in this visual? | For this patient, elevation of the shoulder during the repeat computed tomography (ct) scan (right) as compared with the planning ct scan (left) resulted in reduced coverage of the lower neck region because of greater attenuation of the oblique beams. The effect on the prescription isodose (orange) is significant, but influence on the coverage by the 90% isodose (green) is minimal. |
PMC1891177_f1-co13_3p108_11600.jpg | What is the dominant medical problem in this image? | For this patient, elevation of the shoulder during the repeat computed tomography (ct) scan (right) as compared with the planning ct scan (left) resulted in reduced coverage of the lower neck region because of greater attenuation of the oblique beams. The effect on the prescription isodose (orange) is significant, but influence on the coverage by the 90% isodose (green) is minimal. |
PMC1891193_f2-co14_1p004_11605.jpg | What's the most prominent thing you notice in this picture? | Pre-procedure computed tomography images of the pelvis show a lytic lesion in the left supra-acetabular ilium, abutting the acetabular cortex. |
PMC1891193_f2-co14_1p004_11607.jpg | What can you see in this picture? | Pre-procedure computed tomography images of the pelvis show a lytic lesion in the left supra-acetabular ilium, abutting the acetabular cortex. |
PMC1891271_F1_11612.jpg | What is the dominant medical problem in this image? | Intramural haematoma secondary to balloon angioplasty. Panels A&B: Initial angiography and IVUS examination confirmed ostial LAD disease. Panel C: Post procedure angiography showed a good angiographic result in the LAD. Panel D: IVUS examination of the Cx revealed no evidence of dissection. Panels E&F: Repeat angiography revealed a significant stenosis in the proximal Cx, which was confirmed on IVUS to be intramural haematoma. |
PMC1891271_F1_11611.jpg | What key item or scene is captured in this photo? | Intramural haematoma secondary to balloon angioplasty. Panels A&B: Initial angiography and IVUS examination confirmed ostial LAD disease. Panel C: Post procedure angiography showed a good angiographic result in the LAD. Panel D: IVUS examination of the Cx revealed no evidence of dissection. Panels E&F: Repeat angiography revealed a significant stenosis in the proximal Cx, which was confirmed on IVUS to be intramural haematoma. |
PMC1891284_F4_11615.jpg | What object or scene is depicted here? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891284_F4_11619.jpg | What key item or scene is captured in this photo? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891284_F4_11616.jpg | What object or scene is depicted here? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891284_F4_11617.jpg | What can you see in this picture? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891284_F4_11614.jpg | What object or scene is depicted here? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891284_F4_11618.jpg | What is the dominant medical problem in this image? | Competition of influenza vRNP nuclear import with peptides against NP NLSs. Peptides carrying the NLSs of influenza NP compete for nuclear import of influenza vRNPs. (A) Fluorescein-labeled influenza vRNPs were assayed in digitonin-permeabilized HeLa cells in the presence of cytosol, an energy-regenerating system, and the absence or presence of different peptides. Cells were visualized by confocal microscopy, and representative images of three independent experiments are shown. (B) Bar diagram of the ratio of nuclear-to-cytoplasmic fluorescence for the experimental conditions shown in A. Each bar graph shows the mean value and standard error from 100–110 individual cells. |
PMC1891436_pone-0000559-g006_11624.jpg | What stands out most in this visual? | Histochemical analysis of the spleen and lung of leukemic mice treated with empty liposomes or liposomes containing CDDO or CDDO-Im.Tissues and organs from TRAF2DN/Bcl2 leukemic mice were treated as indicated in the figure. After treatment, tissues were fixed in Z-fix solution (Anatech Ltd.), embedded in paraffin, and tissue sections (5 µm) were stained with hematoxylin and eosin (H&E). One representative example for each treatment is shown. Arrows indicate the presence of infiltrating lymphocytes. |
PMC1891436_pone-0000559-g006_11625.jpg | What object or scene is depicted here? | Histochemical analysis of the spleen and lung of leukemic mice treated with empty liposomes or liposomes containing CDDO or CDDO-Im.Tissues and organs from TRAF2DN/Bcl2 leukemic mice were treated as indicated in the figure. After treatment, tissues were fixed in Z-fix solution (Anatech Ltd.), embedded in paraffin, and tissue sections (5 µm) were stained with hematoxylin and eosin (H&E). One representative example for each treatment is shown. Arrows indicate the presence of infiltrating lymphocytes. |
PMC1891436_pone-0000559-g006_11628.jpg | What is the principal component of this image? | Histochemical analysis of the spleen and lung of leukemic mice treated with empty liposomes or liposomes containing CDDO or CDDO-Im.Tissues and organs from TRAF2DN/Bcl2 leukemic mice were treated as indicated in the figure. After treatment, tissues were fixed in Z-fix solution (Anatech Ltd.), embedded in paraffin, and tissue sections (5 µm) were stained with hematoxylin and eosin (H&E). One representative example for each treatment is shown. Arrows indicate the presence of infiltrating lymphocytes. |
PMC1891436_pone-0000559-g006_11627.jpg | What is the principal component of this image? | Histochemical analysis of the spleen and lung of leukemic mice treated with empty liposomes or liposomes containing CDDO or CDDO-Im.Tissues and organs from TRAF2DN/Bcl2 leukemic mice were treated as indicated in the figure. After treatment, tissues were fixed in Z-fix solution (Anatech Ltd.), embedded in paraffin, and tissue sections (5 µm) were stained with hematoxylin and eosin (H&E). One representative example for each treatment is shown. Arrows indicate the presence of infiltrating lymphocytes. |
PMC1891436_pone-0000559-g006_11629.jpg | Describe the main subject of this image. | Histochemical analysis of the spleen and lung of leukemic mice treated with empty liposomes or liposomes containing CDDO or CDDO-Im.Tissues and organs from TRAF2DN/Bcl2 leukemic mice were treated as indicated in the figure. After treatment, tissues were fixed in Z-fix solution (Anatech Ltd.), embedded in paraffin, and tissue sections (5 µm) were stained with hematoxylin and eosin (H&E). One representative example for each treatment is shown. Arrows indicate the presence of infiltrating lymphocytes. |
PMC1892012_F2_11630.jpg | What is being portrayed in this visual content? | A late role for RAD51C in meiotic recombination. RAD51C's late role in meiotic recombination is revealed in oocytes that were allowed to progress to metaphase II in vivo following hormonal treatment. A. At metaphase II, oocytes from control females show the presence of 20 pairs of chromatids, each consisting of two sister chromatids that are attached at their centromeres. B. Oocytes from infertile Rad51c mutant mice display a variety of chromosomal abnormalities. The majority of the mutant oocytes show precocious separation of sister chromatids. Inset in "D" is a higher magnification of the group of chromosomes showing an acentric chromatid (arrowhead) and a chromatid with two centromeres (double arrow). (Reproduced from The Journal of Cell Biology, 2007, 176:581–592, Copyright 2007, The Rockefeller University Press.) |
PMC1892012_F2_11631.jpg | What can you see in this picture? | A late role for RAD51C in meiotic recombination. RAD51C's late role in meiotic recombination is revealed in oocytes that were allowed to progress to metaphase II in vivo following hormonal treatment. A. At metaphase II, oocytes from control females show the presence of 20 pairs of chromatids, each consisting of two sister chromatids that are attached at their centromeres. B. Oocytes from infertile Rad51c mutant mice display a variety of chromosomal abnormalities. The majority of the mutant oocytes show precocious separation of sister chromatids. Inset in "D" is a higher magnification of the group of chromosomes showing an acentric chromatid (arrowhead) and a chromatid with two centromeres (double arrow). (Reproduced from The Journal of Cell Biology, 2007, 176:581–592, Copyright 2007, The Rockefeller University Press.) |
PMC1892029_F2_11636.jpg | What is the main focus of this visual representation? | Sagittal MRI shows progressive simultaneous ossification of the anterior longitudinal and the posterior longitudinal spinal ligaments respectively and the apparent ankylosed spine fracture (arrow). |
PMC1892030_F1_11632.jpg | What's the most prominent thing you notice in this picture? | Treatment planning computed tomography scan with contoured left anterior descending coronary artery (and part of the left circumflex artery) in green color, left ventricle in orange and heart in purple. |
PMC1892030_F1_11634.jpg | What is the core subject represented in this visual? | Treatment planning computed tomography scan with contoured left anterior descending coronary artery (and part of the left circumflex artery) in green color, left ventricle in orange and heart in purple. |
PMC1892030_F1_11633.jpg | What is shown in this image? | Treatment planning computed tomography scan with contoured left anterior descending coronary artery (and part of the left circumflex artery) in green color, left ventricle in orange and heart in purple. |
PMC1892030_F1_11635.jpg | What is the core subject represented in this visual? | Treatment planning computed tomography scan with contoured left anterior descending coronary artery (and part of the left circumflex artery) in green color, left ventricle in orange and heart in purple. |
PMC1892030_F2_11639.jpg | What is the central feature of this picture? | Treatment planning computed tomography scan with contoured organs at risk (incl. left anterior descending coronary artery in red color, on the small images in green color), clinical target volume (both intermediate and large scenario in the same patient) and isodose distributions for the intermediate scenario with ap-pa (upper left), 4-field (lower left), and 7-field IMRT technique (right) in the same patient. |
PMC1892030_F2_11640.jpg | What is being portrayed in this visual content? | Treatment planning computed tomography scan with contoured organs at risk (incl. left anterior descending coronary artery in red color, on the small images in green color), clinical target volume (both intermediate and large scenario in the same patient) and isodose distributions for the intermediate scenario with ap-pa (upper left), 4-field (lower left), and 7-field IMRT technique (right) in the same patient. |
PMC1892030_F2_11638.jpg | What is being portrayed in this visual content? | Treatment planning computed tomography scan with contoured organs at risk (incl. left anterior descending coronary artery in red color, on the small images in green color), clinical target volume (both intermediate and large scenario in the same patient) and isodose distributions for the intermediate scenario with ap-pa (upper left), 4-field (lower left), and 7-field IMRT technique (right) in the same patient. |
PMC1892030_F2_11637.jpg | What is the dominant medical problem in this image? | Treatment planning computed tomography scan with contoured organs at risk (incl. left anterior descending coronary artery in red color, on the small images in green color), clinical target volume (both intermediate and large scenario in the same patient) and isodose distributions for the intermediate scenario with ap-pa (upper left), 4-field (lower left), and 7-field IMRT technique (right) in the same patient. |
PMC1892052_F3_11642.jpg | What is the core subject represented in this visual? | Inhibition of PRKCZ prevents the nuclear translocation of NFKB p65 subunit induced by LPS in myometrial cells. Cells were treated without (control) or for 120 min with LPS (10 μg/ml) in the absence or presence of AS-ODN (4 μM) directed against human PRKCZmRNA. Cells were fixed, permeabilized and immunostained with antibody against NFKB p65 subunit followed by anti-rabbit FITC (magnification × 400). |
PMC1892052_F3_11643.jpg | Describe the main subject of this image. | Inhibition of PRKCZ prevents the nuclear translocation of NFKB p65 subunit induced by LPS in myometrial cells. Cells were treated without (control) or for 120 min with LPS (10 μg/ml) in the absence or presence of AS-ODN (4 μM) directed against human PRKCZmRNA. Cells were fixed, permeabilized and immunostained with antibody against NFKB p65 subunit followed by anti-rabbit FITC (magnification × 400). |
PMC1892052_F3_11641.jpg | What object or scene is depicted here? | Inhibition of PRKCZ prevents the nuclear translocation of NFKB p65 subunit induced by LPS in myometrial cells. Cells were treated without (control) or for 120 min with LPS (10 μg/ml) in the absence or presence of AS-ODN (4 μM) directed against human PRKCZmRNA. Cells were fixed, permeabilized and immunostained with antibody against NFKB p65 subunit followed by anti-rabbit FITC (magnification × 400). |
PMC1892244_fig1_11646.jpg | What is the focal point of this photograph? | Correlation of MRI and histopathology in post mortem multiple sclerosis brain (same case as in Fig. 2). On the T2-weighted scan of a coronal brain slice seven exemplary regions of interest (marked in orange) were identified as either normal-appearing white matter (NAWM) or white matter lesions (WMLs). Three WMLs are matched to respective histopathological sections, which were stained for hematoxylin and eosin (H&E), Luxol fast blue (LFB), CD68, glial fibrillary acid protein (GFAP) and Bielschowsky silver impregnation. Sections A–F illustrate a demyelinated WML with moderate infiltration by CD68-positive cells indicating chronic inflammatory activity (chronic active WML), and an axonal loss of 74% (compared to NAWM). Sections G–L show a hypo-cellular demyelinated lesion with very little inflammatory activity (chronic inactive WML). Axonal loss in this WML was 93%. Sections M–R show a remyelinated WML again with very little inflammatory activity (remyelinated WML) and an axonal loss of only 42%. Due to their high magnification (× 1250) images of Bielschowsky stained sections were divided into two halves (WML on the left and NAWM on the right). All other sections cover WMLs (red asterisks) as well as NAWM (green asterisks). MD = mean diffusivity × 10− 3 [mm2/s]; FA = fractional anisotropy. |
PMC1892244_fig1_11653.jpg | What does this image primarily show? | Correlation of MRI and histopathology in post mortem multiple sclerosis brain (same case as in Fig. 2). On the T2-weighted scan of a coronal brain slice seven exemplary regions of interest (marked in orange) were identified as either normal-appearing white matter (NAWM) or white matter lesions (WMLs). Three WMLs are matched to respective histopathological sections, which were stained for hematoxylin and eosin (H&E), Luxol fast blue (LFB), CD68, glial fibrillary acid protein (GFAP) and Bielschowsky silver impregnation. Sections A–F illustrate a demyelinated WML with moderate infiltration by CD68-positive cells indicating chronic inflammatory activity (chronic active WML), and an axonal loss of 74% (compared to NAWM). Sections G–L show a hypo-cellular demyelinated lesion with very little inflammatory activity (chronic inactive WML). Axonal loss in this WML was 93%. Sections M–R show a remyelinated WML again with very little inflammatory activity (remyelinated WML) and an axonal loss of only 42%. Due to their high magnification (× 1250) images of Bielschowsky stained sections were divided into two halves (WML on the left and NAWM on the right). All other sections cover WMLs (red asterisks) as well as NAWM (green asterisks). MD = mean diffusivity × 10− 3 [mm2/s]; FA = fractional anisotropy. |
PMC1892244_fig1_11652.jpg | Describe the main subject of this image. | Correlation of MRI and histopathology in post mortem multiple sclerosis brain (same case as in Fig. 2). On the T2-weighted scan of a coronal brain slice seven exemplary regions of interest (marked in orange) were identified as either normal-appearing white matter (NAWM) or white matter lesions (WMLs). Three WMLs are matched to respective histopathological sections, which were stained for hematoxylin and eosin (H&E), Luxol fast blue (LFB), CD68, glial fibrillary acid protein (GFAP) and Bielschowsky silver impregnation. Sections A–F illustrate a demyelinated WML with moderate infiltration by CD68-positive cells indicating chronic inflammatory activity (chronic active WML), and an axonal loss of 74% (compared to NAWM). Sections G–L show a hypo-cellular demyelinated lesion with very little inflammatory activity (chronic inactive WML). Axonal loss in this WML was 93%. Sections M–R show a remyelinated WML again with very little inflammatory activity (remyelinated WML) and an axonal loss of only 42%. Due to their high magnification (× 1250) images of Bielschowsky stained sections were divided into two halves (WML on the left and NAWM on the right). All other sections cover WMLs (red asterisks) as well as NAWM (green asterisks). MD = mean diffusivity × 10− 3 [mm2/s]; FA = fractional anisotropy. |
PMC1892244_fig1_11655.jpg | What is the dominant medical problem in this image? | Correlation of MRI and histopathology in post mortem multiple sclerosis brain (same case as in Fig. 2). On the T2-weighted scan of a coronal brain slice seven exemplary regions of interest (marked in orange) were identified as either normal-appearing white matter (NAWM) or white matter lesions (WMLs). Three WMLs are matched to respective histopathological sections, which were stained for hematoxylin and eosin (H&E), Luxol fast blue (LFB), CD68, glial fibrillary acid protein (GFAP) and Bielschowsky silver impregnation. Sections A–F illustrate a demyelinated WML with moderate infiltration by CD68-positive cells indicating chronic inflammatory activity (chronic active WML), and an axonal loss of 74% (compared to NAWM). Sections G–L show a hypo-cellular demyelinated lesion with very little inflammatory activity (chronic inactive WML). Axonal loss in this WML was 93%. Sections M–R show a remyelinated WML again with very little inflammatory activity (remyelinated WML) and an axonal loss of only 42%. Due to their high magnification (× 1250) images of Bielschowsky stained sections were divided into two halves (WML on the left and NAWM on the right). All other sections cover WMLs (red asterisks) as well as NAWM (green asterisks). MD = mean diffusivity × 10− 3 [mm2/s]; FA = fractional anisotropy. |
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