question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Mutation found at chromosome 5 position 16483488, gene RETREG1 (reticulophagy regulator 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GCTCATTTAAGGAAATTAATGCGGCCTGATAACTACATCTGAAAGTTCAAACTACCACTATAAGCCCACTGAAATTCATAAAAACACAGCAAAACAAGTTACAGAAATTAGAGGTATCTACACAAATCTAACGTAATTTACACAAATCTAATGTAATTTATAGCTGCTAAGCTGACAGGATAAATTTATGGCCATCACTATCCTCTTTCCTAACCATATATACTGCTCAAACTGACCCCACTTCTAAGTCACCTAGAAAAAAACTGCCATTGAAATGAAACTCCTACAGTGACATGTTTATTTTCCTTCTGTCATTTATG...
GCTCATTTAAGGAAATTAATGCGGCCTGATAACTACATCTGAAAGTTCAAACTACCACTATAAGCCCACTGAAATTCATAAAAACACAGCAAAACAAGTTACAGAAATTAGAGGTATCTACACAAATCTAACGTAATTTACACAAATCTAATGTAATTTATAGCTGCTAAGCTGACAGGATAAATTTATGGCCATCACTATCCTCTTTCCTAACCATATATACTGCTCAAACTGACCCCACTTCTAAGTCACCTAGAAAAAAACTGCCATTGAAATGAAACTCCTACAGTGACATGTTTATTTTCCTTCTGTCATTTATG...
benign
91,353
Variant at chromosome position 16616900, chromosome 5, gene RETREG1: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Inborn_genetic_diseases']
AAATACTAGGAAAAGGAAGAGCTCATATGTTATTCCACAATTTGCATAGAATATGGTGTATTTGCTGAAATGTGCACTATCTGGAAAGAGACACAGGAAACTAGCAACATTGCTGGCCTCCGTGAGGAAACTGGGCGGCCAGGGACTGGGATGAGAAAGAGATTTTCAAAATGCTTACCCTTTTGTACCTTTAAACTTTTGCACTGTGAGACTGTATTAGTTTTTTAAAGAAATAAAATTTAAAATTAAGAAATAAAATGTTAAGGCCGGGCGCAGTAGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGA...
AAATACTAGGAAAAGGAAGAGCTCATATGTTATTCCACAATTTGCATAGAATATGGTGTATTTGCTGAAATGTGCACTATCTGGAAAGAGACACAGGAAACTAGCAACATTGCTGGCCTCCGTGAGGAAACTGGGCGGCCAGGGACTGGGATGAGAAAGAGATTTTCAAAATGCTTACCCTTTTGTACCTTTAAACTTTTGCACTGTGAGACTGTATTAGTTTTTTAAAGAAATAAAATTTAAAATTAAGAAATAAAATGTTAAGGCCGGGCGCAGTAGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGA...
pathogenic
91,367
Is the genetic change at chromosome 5, position 16616952, within gene RETREG1 benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Charcot-Marie-Tooth_disease', 'Hereditary_sensory_and_autonomic_neuropathy_type_2', 'Inborn_genetic_diseases', 'Neuropathy,_hereditary_sensory_and_autonomic,_type_2B']
ATGGTGTATTTGCTGAAATGTGCACTATCTGGAAAGAGACACAGGAAACTAGCAACATTGCTGGCCTCCGTGAGGAAACTGGGCGGCCAGGGACTGGGATGAGAAAGAGATTTTCAAAATGCTTACCCTTTTGTACCTTTAAACTTTTGCACTGTGAGACTGTATTAGTTTTTTAAAGAAATAAAATTTAAAATTAAGAAATAAAATGTTAAGGCCGGGCGCAGTAGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCC...
ATGGTGTATTTGCTGAAATGTGCACTATCTGGAAAGAGACACAGGAAACTAGCAACATTGCTGGCCTCCGTGAGGAAACTGGGCGGCCAGGGACTGGGATGAGAAAGAGATTTTCAAAATGCTTACCCTTTTGTACCTTTAAACTTTTGCACTGTGAGACTGTATTAGTTTTTTAAAGAAATAAAATTTAAAATTAAGAAATAAAATGTTAAGGCCGGGCGCAGTAGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGACGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCC...
pathogenic
91,370
Clinical classification of chromosome 5, position 33944805, gene SLC45A2 (solute carrier family 45 member 2): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Oculocutaneous_albinism_type_4']
AGGACTCTACACTGCCTAGGTAGAGAGAGGAGTGGGGGAAGCAGTGAAGAGGGATGGGCTGTGGATCACATGCCTCCATTCATGTGCCAGACACCAGGCTAAGTGCTGTCCATACAGGAAGCAACGGAACCAAAGTGACTGGGTTCAAAGCCCAGCTCTGTCACTTAAGAATTGTGTGGTTTCAGATAAGTTATATCTTTCTGCCTCCATTTCTTTATCTAAAAAATGGAGAGTGGTAACAGCACCCACTCCCACAATTGCTGTGTTAACGTTAAAGCATTTAGAATAGTGGTAAAGACTCCATAAATGTCATGGTTTGT...
AGGACTCTACACTGCCTAGGTAGAGAGAGGAGTGGGGGAAGCAGTGAAGAGGGATGGGCTGTGGATCACATGCCTCCATTCATGTGCCAGACACCAGGCTAAGTGCTGTCCATACAGGAAGCAACGGAACCAAAGTGACTGGGTTCAAAGCCCAGCTCTGTCACTTAAGAATTGTGTGGTTTCAGATAAGTTATATCTTTCTGCCTCCATTTCTTTATCTAAAAAATGGAGAGTGGTAACAGCACCCACTCCCACAATTGCTGTGTTAACGTTAAAGCATTTAGAATAGTGGTAAAGACTCCATAAATGTCATGGTTTGT...
pathogenic
91,485
Does the variant on chromosome 5 at location 33947257 affecting gene SLC45A2 (solute carrier family 45 member 2) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Oculocutaneous_albinism_type_4', 'SKIN/HAIR/EYE_PIGMENTATION_5,_BLACK/NONBLACK_HAIR']
TGAAAGTTTTTTTCAATCATTTAAACAATTAAAAGGAATTCTTAGCTCGCAGACTGTACAAAAACAAGTGGCGGGCCATAATCAATACAATGTAGTGGATACTTAATAAATATCCCATTCTTTTCCTTTCTTAGTGTTAAAAATTCAAAGATTTTAAGAAGGATGTTGAATTGCTGATGTCCTTAAGAGAAGCAACTTTAAAAAGCATTTCAATCTTTCAAAATATGGTTGCTACTTGATTAATATAATAATGTTTGGTTAATACTTGATATTTCTTCCGAACTGGCTGATAACTTTGTCATTTGTTGGGTATCGCTTAT...
TGAAAGTTTTTTTCAATCATTTAAACAATTAAAAGGAATTCTTAGCTCGCAGACTGTACAAAAACAAGTGGCGGGCCATAATCAATACAATGTAGTGGATACTTAATAAATATCCCATTCTTTTCCTTTCTTAGTGTTAAAAATTCAAAGATTTTAAGAAGGATGTTGAATTGCTGATGTCCTTAAGAGAAGCAACTTTAAAAAGCATTTCAATCTTTCAAAATATGGTTGCTACTTGATTAATATAATAATGTTTGGTTAATACTTGATATTTCTTCCGAACTGGCTGATAACTTTGTCATTTGTTGGGTATCGCTTAT...
pathogenic
91,489
For chromosome 5, position 33947363, gene SLC45A2 (solute carrier family 45 member 2): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Oculocutaneous_albinism_type_4', 'SKIN/HAIR/EYE_PIGMENTATION_5,_BLACK/NONBLACK_HAIR']
TAAATATCCCATTCTTTTCCTTTCTTAGTGTTAAAAATTCAAAGATTTTAAGAAGGATGTTGAATTGCTGATGTCCTTAAGAGAAGCAACTTTAAAAAGCATTTCAATCTTTCAAAATATGGTTGCTACTTGATTAATATAATAATGTTTGGTTAATACTTGATATTTCTTCCGAACTGGCTGATAACTTTGTCATTTGTTGGGTATCGCTTATGTGCTGGGCCTGGGTTTTTTTTTTACCTGTTACTGTATTTCAACCTCACCACCTCCCTGGATGCACATGTTATTATCATTACCCCCATGGTAACAATTATAATACT...
TAAATATCCCATTCTTTTCCTTTCTTAGTGTTAAAAATTCAAAGATTTTAAGAAGGATGTTGAATTGCTGATGTCCTTAAGAGAAGCAACTTTAAAAAGCATTTCAATCTTTCAAAATATGGTTGCTACTTGATTAATATAATAATGTTTGGTTAATACTTGATATTTCTTCCGAACTGGCTGATAACTTTGTCATTTGTTGGGTATCGCTTATGTGCTGGGCCTGGGTTTTTTTTTTACCTGTTACTGTATTTCAACCTCACCACCTCCCTGGATGCACATGTTATTATCATTACCCCCATGGTAACAATTATAATACT...
pathogenic
91,492
Chromosome 5, position 33954406, gene SLC45A2 (solute carrier family 45 member 2): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Oculocutaneous_albinism_type_4', 'SKIN/HAIR/EYE_PIGMENTATION_5,_BLACK/NONBLACK_HAIR']
TTGTATTTTTTTTTTTTGTAGTTTCAGCATTTTATTTCTTATTTTGATTCAAGATGTGAGAGGTATTACAAACACTCAATTATGAGTGATGCATTTACGTGTCCTATTCTTCCATCTGTAGATAAGTGAAAAGTCATTTAAGAAATTAGAGGTCTCTGTAGTAAATCCAAGTCACAGTAAAGCAAACAAAAATGCATATGTGTGTGATATAATGTGGAACTTTACCCCCTTGGAAGACTTTGCAGGCTGTAAGAATTTCATTTTTAATGTATTTCATACAGGCCGGAGCTAACAAGTTAATTTCTATTGAGCAAAAGTTT...
TTGTATTTTTTTTTTTTGTAGTTTCAGCATTTTATTTCTTATTTTGATTCAAGATGTGAGAGGTATTACAAACACTCAATTATGAGTGATGCATTTACGTGTCCTATTCTTCCATCTGTAGATAAGTGAAAAGTCATTTAAGAAATTAGAGGTCTCTGTAGTAAATCCAAGTCACAGTAAAGCAAACAAAAATGCATATGTGTGTGATATAATGTGGAACTTTACCCCCTTGGAAGACTTTGCAGGCTGTAAGAATTTCATTTTTAATGTATTTCATACAGGCCGGAGCTAACAAGTTAATTTCTATTGAGCAAAAGTTT...
pathogenic
91,501
Gene SLC45A2 (solute carrier family 45 member 2) variant at chromosome 5, position 33963776—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Oculocutaneous_albinism_type_4', 'SKIN/HAIR/EYE_PIGMENTATION_5,_BLACK/NONBLACK_HAIR']
TGCTGCCTCTCTGGATCCACTGTTCCTGTTCCTGCCAAGGAACTCTGTTCCTGTACCTGTTCCTGCCAAAGTTACCCCTTTCCTGGCTGTTCCCAGATAGTGACTAACAAGACGGGGGGTATTAGTGTTAGCCTGTTCCTACAAGAGTTGGGACTCCTCTAAGGAGCAACTTTGGCTGGAGGACTCCCATTTGGCCTGAGTGAAGCTTTCTTGAAACTTCACTGCATCTGAGAGGCTTCCTACCCTATCCTCTTTCCTTTCCTTTCTCCTTTCACAGGTGTTTGACTTGCATCAACATAAGAAGACTTTCCCTTCCTATT...
TGCTGCCTCTCTGGATCCACTGTTCCTGTTCCTGCCAAGGAACTCTGTTCCTGTACCTGTTCCTGCCAAAGTTACCCCTTTCCTGGCTGTTCCCAGATAGTGACTAACAAGACGGGGGGTATTAGTGTTAGCCTGTTCCTACAAGAGTTGGGACTCCTCTAAGGAGCAACTTTGGCTGGAGGACTCCCATTTGGCCTGAGTGAAGCTTTCTTGAAACTTCACTGCATCTGAGAGGCTTCCTACCCTATCCTCTTTCCTTTCCTTTCTCCTTTCACAGGTGTTTGACTTGCATCAACATAAGAAGACTTTCCCTTCCTATT...
pathogenic
91,506
Variant at chromosome 5, position 33963914, gene SLC45A2 (solute carrier family 45 member 2): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Oculocutaneous_albinism_type_4']
CTACAAGAGTTGGGACTCCTCTAAGGAGCAACTTTGGCTGGAGGACTCCCATTTGGCCTGAGTGAAGCTTTCTTGAAACTTCACTGCATCTGAGAGGCTTCCTACCCTATCCTCTTTCCTTTCCTTTCTCCTTTCACAGGTGTTTGACTTGCATCAACATAAGAAGACTTTCCCTTCCTATTTCTGCTTTCTCCACTTTATCTTTCATGCTGTTTTCTCCAATGAATCTCTTACATGTCAAATCCTATCTTGGTGCCTTTTTAAAAGATCTGAACTGATACATTGTTTTATAGCATTTACCATGTTCTATCATGGATTAT...
CTACAAGAGTTGGGACTCCTCTAAGGAGCAACTTTGGCTGGAGGACTCCCATTTGGCCTGAGTGAAGCTTTCTTGAAACTTCACTGCATCTGAGAGGCTTCCTACCCTATCCTCTTTCCTTTCCTTTCTCCTTTCACAGGTGTTTGACTTGCATCAACATAAGAAGACTTTCCCTTCCTATTTCTGCTTTCTCCACTTTATCTTTCATGCTGTTTTCTCCAATGAATCTCTTACATGTCAAATCCTATCTTGGTGCCTTTTTAAAAGATCTGAACTGATACATTGTTTTATAGCATTTACCATGTTCTATCATGGATTAT...
pathogenic
91,508
Is the genetic mutation found on chromosome 5 at position 33982263, within the gene SLC45A2 (solute carrier family 45 member 2), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Oculocutaneous_albinism_type_4', 'SLC45A2-related_disorder']
TCCTACTCCAATCAGTGGACTTCAGGTAAATATTTAACAACTGGCTTTCCAAGAAAAAAAAAAAAACCATGATTTATAGCTTTGCCAATTTCTAGAGTTTTAATACTGCCATCATGGCCAGTTTCAAGCCAGCAATATGATGTCAACAAGTTCACTGAATTCCTAAAATTTGACAATTGATTCTCAAGAAGCCAGCATGAGCCAGCTGTAAGCACACCACTGCTTTCAAGGCTCAGCTTCCACATCTGAAAAATGGGAATCACACCACTTCCACATGGCCATTGTCAGGATCGAGATAATGTAAGAGAAAATACCTAATA...
TCCTACTCCAATCAGTGGACTTCAGGTAAATATTTAACAACTGGCTTTCCAAGAAAAAAAAAAAAACCATGATTTATAGCTTTGCCAATTTCTAGAGTTTTAATACTGCCATCATGGCCAGTTTCAAGCCAGCAATATGATGTCAACAAGTTCACTGAATTCCTAAAATTTGACAATTGATTCTCAAGAAGCCAGCATGAGCCAGCTGTAAGCACACCACTGCTTTCAAGGCTCAGCTTCCACATCTGAAAAATGGGAATCACACCACTTCCACATGGCCATTGTCAGGATCGAGATAATGTAAGAGAAAATACCTAATA...
pathogenic
91,514
Does the chromosome 5 mutation at position 33984319 within gene SLC45A2 (solute carrier family 45 member 2) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Oculocutaneous_albinism_type_4', 'SKIN/HAIR/EYE_PIGMENTATION_5,_BLACK/NONBLACK_HAIR', 'SLC45A2-related_disorder']
TTGTCCTGATGGGAGCAGACATCAAATAAGTAGGCTTTGATGGGCCCATCAATGAAGTCGGCAGCAAAATCAAAGAGAACGACACCTATCATGGTGACACTTATGGCCCAAACCAGCTTCCTCCTTGGGTTAGCAATCAAAGCTAAAAGAAAAATAAACATTGGTCTCCTAAATCCTGTTTTAGAATCATCCGCGTTTTGTAATTTCCACCTAAACTTCTTGCCATAAAATCATCTTCCTTGCTTTTATTTTGCTTTTTTCCAAATAAAAATAGCTTTACATTTTTTTTCAGGTTTTAAAAATTATGCAAGCGAATGTCC...
TTGTCCTGATGGGAGCAGACATCAAATAAGTAGGCTTTGATGGGCCCATCAATGAAGTCGGCAGCAAAATCAAAGAGAACGACACCTATCATGGTGACACTTATGGCCCAAACCAGCTTCCTCCTTGGGTTAGCAATCAAAGCTAAAAGAAAAATAAACATTGGTCTCCTAAATCCTGTTTTAGAATCATCCGCGTTTTGTAATTTCCACCTAAACTTCTTGCCATAAAATCATCTTCCTTGCTTTTATTTTGCTTTTTTCCAAATAAAAATAGCTTTACATTTTTTTTCAGGTTTTAAAAATTATGCAAGCGAATGTCC...
pathogenic
91,522
The mutation in gene DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21) at chromosome 5, position 34950206—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Bone_marrow_failure_syndrome_3']
TTGGATTGAAGTGGAGATGTTGGTATGAGCCCATGATTTAAAGAAAGTAAGTGTGTGAGCAGTGTGCATTGTGAGGACCTAGAAGCAGTGACACCCCTAGCAGTGAGTACACCTAATGCACACGTTTTGGTTTTTAAGTTCACTTTTCCATGAAAAGGAAACAGGCTTGCTCTTTGGAGAAATACCTGATTTCAGGGCTGAGACTAGGAAAGTGGAACGTGAGCCTAGAGCATCTTATACTAGAAACTAAGGAAGTGCTCAAAAACTGATGGGGATACGTTAGAAGTACTCAAGATCCAGCTTGCGGGGCCTGCCAGTTA...
TTGGATTGAAGTGGAGATGTTGGTATGAGCCCATGATTTAAAGAAAGTAAGTGTGTGAGCAGTGTGCATTGTGAGGACCTAGAAGCAGTGACACCCCTAGCAGTGAGTACACCTAATGCACACGTTTTGGTTTTTAAGTTCACTTTTCCATGAAAAGGAAACAGGCTTGCTCTTTGGAGAAATACCTGATTTCAGGGCTGAGACTAGGAAAGTGGAACGTGAGCCTAGAGCATCTTATACTAGAAACTAAGGAAGTGCTCAAAAACTGATGGGGATACGTTAGAAGTACTCAAGATCCAGCTTGCGGGGCCTGCCAGTTA...
pathogenic
91,573
Located at chromosome 5 position 35867354, the variant affecting gene IL7R (interleukin 7 receptor)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Immunodeficiency_104', 'Severe_combined_immunodeficiency_disease']
TGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCTATCATTGATGGACATTTGGCTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCTGCAATAATCGTACATGTGCATGTGTCTTTATAGCAGCATGATTTATACTCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATAGTATTTCTAGCTCTGGATCCTTGAGGACTCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATTCCCTCCAGCACCTTTTGT...
TGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCTATCATTGATGGACATTTGGCTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCTGCAATAATCGTACATGTGCATGTGTCTTTATAGCAGCATGATTTATACTCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATAGTATTTCTAGCTCTGGATCCTTGAGGACTCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATTCCCTCCAGCACCTTTTGT...
pathogenic
91,665
Gene IL7R (interleukin 7 receptor) variant at chromosome position 35867438 on chromosome 5: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Immunodeficiency_104', 'Multiple_sclerosis,_susceptibility_to,_3', 'Severe_combined_immunodeficiency_disease']
TGCTATTGTGAATAGTGCTGCAATAATCGTACATGTGCATGTGTCTTTATAGCAGCATGATTTATACTCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATAGTATTTCTAGCTCTGGATCCTTGAGGACTCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATTCCCTCCAGCACCTTTTGTTTCCTGACTTTTTAATGATCACCATTCTAACTGGTGTGAGATGGTATGTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCA...
TGCTATTGTGAATAGTGCTGCAATAATCGTACATGTGCATGTGTCTTTATAGCAGCATGATTTATACTCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCAAATAGTATTTCTAGCTCTGGATCCTTGAGGACTCGCCACACTGTCTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATTCCCTCCAGCACCTTTTGTTTCCTGACTTTTTAATGATCACCATTCTAACTGGTGTGAGATGGTATGTCATTGTGGTTTTGATTTGCATTTCTCTGATGGCCA...
pathogenic
91,670
Mutation at chromosome 5, position 35871111, within IL7R (interleukin 7 receptor): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Immunodeficiency_104', 'Severe_combined_immunodeficiency_disease']
GTGGAGGCATGTCTCACGGTAGCATCTCCTTCTAGGTCCTAATGGGACACTTCATTAATGGAACTACCATTTAAGTGAGTTTAAACTGGATGCTTCTGATTGAGCCCCAGAGCCAGTGCTCCACTGCCACCACCTGCACCCTCACTTCCCCTTGTTTAAGCATCTTCCAACCCAGTAAGGCTGAAGAGGGAAGCATCCTGCCTTCCCACTTCTCTTAGCAGAGTAGATTGATATGATTATTCAGATTGTACAAGAATCTATTCCCTCTGAAGTATTGCTTGATGAATGAGCCCCTTTTTCTAATTTGCTCAAAGAAATCA...
GTGGAGGCATGTCTCACGGTAGCATCTCCTTCTAGGTCCTAATGGGACACTTCATTAATGGAACTACCATTTAAGTGAGTTTAAACTGGATGCTTCTGATTGAGCCCCAGAGCCAGTGCTCCACTGCCACCACCTGCACCCTCACTTCCCCTTGTTTAAGCATCTTCCAACCCAGTAAGGCTGAAGAGGGAAGCATCCTGCCTTCCCACTTCTCTTAGCAGAGTAGATTGATATGATTATTCAGATTGTACAAGAATCTATTCCCTCTGAAGTATTGCTTGATGAATGAGCCCCTTTTTCTAATTTGCTCAAAGAAATCA...
pathogenic
91,676
Evaluate the clinical significance of the mutation at chromosome 5, position 36877180 in gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
ACTGTGTGGCATTCTAGGCGGGGGCCGTAACACCAGTGCAGAAAAACACAACCTCTTGTCCTCTTAGAGCTTACATTGCACTGGGGAAGGAGAGATAAGAAGATAAACAAGTATGGATATGTAGACTGTCCAAAGGATAAAATGAGAAGGGGGCTAGGGAACTTTCAGTTTAAAAGTAGCCGCGGAAGCACCGAGTGACACGAGCAAAATCCTGAAGGTGAAGGAGCAAGCCCTGTGGACGACGCTCAGGGAAGAGTCCTACTCGCAAGGATGCCAGGGCAGGCCCGCCCCCACCCTCAACGGCGCGCGGGGACTTCTGC...
ACTGTGTGGCATTCTAGGCGGGGGCCGTAACACCAGTGCAGAAAAACACAACCTCTTGTCCTCTTAGAGCTTACATTGCACTGGGGAAGGAGAGATAAGAAGATAAACAAGTATGGATATGTAGACTGTCCAAAGGATAAAATGAGAAGGGGGCTAGGGAACTTTCAGTTTAAAAGTAGCCGCGGAAGCACCGAGTGACACGAGCAAAATCCTGAAGGTGAAGGAGCAAGCCCTGTGGACGACGCTCAGGGAAGAGTCCTACTCGCAAGGATGCCAGGGCAGGCCCGCCCCCACCCTCAACGGCGCGCGGGGACTTCTGC...
benign
91,802
A genetic variant on chromosome 5, position 36955491, affects the gene NIPBL (NIPBL cohesin loading factor). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TGTGTGCAAAGCACTTTGCAATTGCTTAACATGTAATAAGTGGTATGTGAAAATGATTATTATATAGGTTGAACAAACCAAAGCAGTAACTTTTTTTTATAGTGATTAAGCATTTTCCTGATAGTAATATATCTGACATATCTCTACAAATAATTGTCTGTTTTGTGTGTTGCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCGT...
TGTGTGCAAAGCACTTTGCAATTGCTTAACATGTAATAAGTGGTATGTGAAAATGATTATTATATAGGTTGAACAAACCAAAGCAGTAACTTTTTTTTATAGTGATTAAGCATTTTCCTGATAGTAATATATCTGACATATCTCTACAAATAATTGTCTGTTTTGTGTGTTGCAGTGTTTGGGAAATGGGAAGTAATGACAGCTGGCACCTGAACTAAGTACTTTTATAGGCAACACCATTCCAGAAATTCAGGATGAATGGGGATATGCCCCATGTCCCCATTACTACTCTTGCGGGGATTGCTAGTCTCACAGACCGT...
pathogenic
91,808
Is the genetic variant on chromosome 5, position 36976406, gene NIPBL (NIPBL cohesin loading factor), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
ATTAATTATTAGAATTTGAAGTTTGTTCTAAAGTGTATATAATTTGCCACATAGAATTTAAATACAAAGGCATAATGGTATATTACAATTCAGACTTAGACAAATCTTGTTTTAAATCTTCAGGTTTGTTAACTACATAACCTTGGGCAAATTTCTTAACCTCTGTAGGCTTCATGTTCCATTTCTGAAAAATTTTAAAGATAATACTCAAGAATGTTGTAAAAATCAAGTGAATTGATATGTAAAGCACCTTTCACAACTCTGACACAAAATGTTAGACTAACATTTATAGTTAATTGCTCCCATATCATCTTTATCAC...
ATTAATTATTAGAATTTGAAGTTTGTTCTAAAGTGTATATAATTTGCCACATAGAATTTAAATACAAAGGCATAATGGTATATTACAATTCAGACTTAGACAAATCTTGTTTTAAATCTTCAGGTTTGTTAACTACATAACCTTGGGCAAATTTCTTAACCTCTGTAGGCTTCATGTTCCATTTCTGAAAAATTTTAAAGATAATACTCAAGAATGTTGTAAAAATCAAGTGAATTGATATGTAAAGCACCTTTCACAACTCTGACACAAAATGTTAGACTAACATTTATAGTTAATTGCTCCCATATCATCTTTATCAC...
benign
91,838
Variant on chromosome 5, at position 36984980, affecting NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['NIPBL-related_disorder']
AGAAATCTTAGGTTATATTTTTTGAATTTCTAGAGTCTTATAAAAGTTTAAGGGATAAGCATAAATTGATAAAGCATCTTATTCATGAGATATCAATTGGTTTGCCCTGTGGCAGAACATAAAGATGATTTTTGAATGGCAGAACATTCTAAAAGAGGATTCTATAAACATAAATTTAGTATTCTGATTTCTTTTTTAAGGTATTGATGTAGAAAACTTCCTATAAATTCTTACCATGTTAGTTTTAACTGGTGGAAACAATCTAATGATAATATATTATACTTTAGAATTAAAATGGTAGTGTTTTGCAAATGGAGCAT...
AGAAATCTTAGGTTATATTTTTTGAATTTCTAGAGTCTTATAAAAGTTTAAGGGATAAGCATAAATTGATAAAGCATCTTATTCATGAGATATCAATTGGTTTGCCCTGTGGCAGAACATAAAGATGATTTTTGAATGGCAGAACATTCTAAAAGAGGATTCTATAAACATAAATTTAGTATTCTGATTTCTTTTTTAAGGTATTGATGTAGAAAACTTCCTATAAATTCTTACCATGTTAGTTTTAACTGGTGGAAACAATCTAATGATAATATATTATACTTTAGAATTAAAATGGTAGTGTTTTGCAAATGGAGCAT...
pathogenic
91,841
Variant on chromosome 5, at position 36984980, affecting NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
AGAAATCTTAGGTTATATTTTTTGAATTTCTAGAGTCTTATAAAAGTTTAAGGGATAAGCATAAATTGATAAAGCATCTTATTCATGAGATATCAATTGGTTTGCCCTGTGGCAGAACATAAAGATGATTTTTGAATGGCAGAACATTCTAAAAGAGGATTCTATAAACATAAATTTAGTATTCTGATTTCTTTTTTAAGGTATTGATGTAGAAAACTTCCTATAAATTCTTACCATGTTAGTTTTAACTGGTGGAAACAATCTAATGATAATATATTATACTTTAGAATTAAAATGGTAGTGTTTTGCAAATGGAGCAT...
AGAAATCTTAGGTTATATTTTTTGAATTTCTAGAGTCTTATAAAAGTTTAAGGGATAAGCATAAATTGATAAAGCATCTTATTCATGAGATATCAATTGGTTTGCCCTGTGGCAGAACATAAAGATGATTTTTGAATGGCAGAACATTCTAAAAGAGGATTCTATAAACATAAATTTAGTATTCTGATTTCTTTTTTAAGGTATTGATGTAGAAAACTTCCTATAAATTCTTACCATGTTAGTTTTAACTGGTGGAAACAATCTAATGATAATATATTATACTTTAGAATTAAAATGGTAGTGTTTTGCAAATGGAGCAT...
pathogenic
91,842
The mutation in gene NIPBL (NIPBL cohesin loading factor) at chromosome 5, position 36985640—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TAACAGTGACTTTTAAAACATACTCAAGCAATTCAGCAAATAAACAAAAGGAAGCCAAACCTCAAGGTGCTATAATGTAACCATTCCCAAGACCTAACTGGAGATTTAATTTATAGAAAATGACTAGCTCCCTCTTAAGTCAGAAATGGAATCATACACAGAAATATATAGATGTTAAAAATACCTTCACATTTTATTGTAATGGTGAATTTGTGTTTGTGTGTGTGTTTGTCTTTACATTTCATAATACTGTAAATTATTTCTTTCTGAGACCAGAATGGATCCCAGAACATTATAACTTTATATCGAAGAGTAGGAAC...
TAACAGTGACTTTTAAAACATACTCAAGCAATTCAGCAAATAAACAAAAGGAAGCCAAACCTCAAGGTGCTATAATGTAACCATTCCCAAGACCTAACTGGAGATTTAATTTATAGAAAATGACTAGCTCCCTCTTAAGTCAGAAATGGAATCATACACAGAAATATATAGATGTTAAAAATACCTTCACATTTTATTGTAATGGTGAATTTGTGTTTGTGTGTGTGTTTGTCTTTACATTTCATAATACTGTAAATTATTTCTTTCTGAGACCAGAATGGATCCCAGAACATTATAACTTTATATCGAAGAGTAGGAAC...
pathogenic
91,859
The mutation in gene NIPBL (NIPBL cohesin loading factor) at chromosome 5, position 36985658—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
CATACTCAAGCAATTCAGCAAATAAACAAAAGGAAGCCAAACCTCAAGGTGCTATAATGTAACCATTCCCAAGACCTAACTGGAGATTTAATTTATAGAAAATGACTAGCTCCCTCTTAAGTCAGAAATGGAATCATACACAGAAATATATAGATGTTAAAAATACCTTCACATTTTATTGTAATGGTGAATTTGTGTTTGTGTGTGTGTTTGTCTTTACATTTCATAATACTGTAAATTATTTCTTTCTGAGACCAGAATGGATCCCAGAACATTATAACTTTATATCGAAGAGTAGGAACTGTTTCCTTCAGTGGAAG...
CATACTCAAGCAATTCAGCAAATAAACAAAAGGAAGCCAAACCTCAAGGTGCTATAATGTAACCATTCCCAAGACCTAACTGGAGATTTAATTTATAGAAAATGACTAGCTCCCTCTTAAGTCAGAAATGGAATCATACACAGAAATATATAGATGTTAAAAATACCTTCACATTTTATTGTAATGGTGAATTTGTGTTTGTGTGTGTGTTTGTCTTTACATTTCATAATACTGTAAATTATTTCTTTCTGAGACCAGAATGGATCCCAGAACATTATAACTTTATATCGAAGAGTAGGAACTGTTTCCTTCAGTGGAAG...
pathogenic
91,861
Is chromosome 5, position 36986237, gene NIPBL (NIPBL cohesin loading factor) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TATCTTAGATACAGTAAAAACTTATATTTCCTGTTTGGTATATTGGCAGATTTGGAGCTCTTTATGGTTTTTGGCTAACAGTTAAAAGTAACCTGAGTGAGACTTTATGATTTGTAACTGGTTGCTTTATTATTAGGAAAAGAATCTGATTTATCCGTGACATCTATGAACATAAATATATGTTTGTATTTGGTACATTATAAGTTCTATTCATTTTATATTCTTACACTTATTTATATCCTTAAAGAGTATGCAGTTAAATTCTTTTTACTATATTTATTGAGATCTCTCAAGCATATTTCTTCAAACCTTACCTTTCA...
TATCTTAGATACAGTAAAAACTTATATTTCCTGTTTGGTATATTGGCAGATTTGGAGCTCTTTATGGTTTTTGGCTAACAGTTAAAAGTAACCTGAGTGAGACTTTATGATTTGTAACTGGTTGCTTTATTATTAGGAAAAGAATCTGATTTATCCGTGACATCTATGAACATAAATATATGTTTGTATTTGGTACATTATAAGTTCTATTCATTTTATATTCTTACACTTATTTATATCCTTAAAGAGTATGCAGTTAAATTCTTTTTACTATATTTATTGAGATCTCTCAAGCATATTTCTTCAAACCTTACCTTTCA...
pathogenic
91,870
Does the genetic variant at chromosome 5, position 37007373, impacting gene NIPBL (NIPBL cohesin loading factor), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TCCATTGTTAGTCTACAAGTTACTTAAATACTTCGCCAAGAAATTGTGATAATCATCATCAGAAATCTAGAGTTCTGGAGAGCTGGCTGACTCAGTCTTAAGGAAATTACTTTCATCCCTAAAAACCGTAACAGTATTTAATATGTTGTGGATAGCCTTAACGTTTGGCATGAATCATGAGCCTCCTTAACTGACTCTTCCAAACAAACAGCAATGTTCGCATCAAAGACAAGCTACTTTATCTTTCCTTTGTGAGGTTTTAGGCATTACTGAACAGAAAGCCCTGTCTGCTTTACATATTATATATCGTGTTTTTGTTC...
TCCATTGTTAGTCTACAAGTTACTTAAATACTTCGCCAAGAAATTGTGATAATCATCATCAGAAATCTAGAGTTCTGGAGAGCTGGCTGACTCAGTCTTAAGGAAATTACTTTCATCCCTAAAAACCGTAACAGTATTTAATATGTTGTGGATAGCCTTAACGTTTGGCATGAATCATGAGCCTCCTTAACTGACTCTTCCAAACAAACAGCAATGTTCGCATCAAAGACAAGCTACTTTATCTTTCCTTTGTGAGGTTTTAGGCATTACTGAACAGAAAGCCCTGTCTGCTTTACATATTATATATCGTGTTTTTGTTC...
pathogenic
91,893
The mutation impacting NIPBL (NIPBL cohesin loading factor) on chromosome 5 at position 37007457: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Cornelia_de_Lange_syndrome_1']
GGCTGACTCAGTCTTAAGGAAATTACTTTCATCCCTAAAAACCGTAACAGTATTTAATATGTTGTGGATAGCCTTAACGTTTGGCATGAATCATGAGCCTCCTTAACTGACTCTTCCAAACAAACAGCAATGTTCGCATCAAAGACAAGCTACTTTATCTTTCCTTTGTGAGGTTTTAGGCATTACTGAACAGAAAGCCCTGTCTGCTTTACATATTATATATCGTGTTTTTGTTCGTTTTCCTAGGGTATAAGCTTTGAATTGGAAGTAGTCCTGTAATATAGTTTATATTTCATAACTAAAGATGTGATAGAAGGATT...
GGCTGACTCAGTCTTAAGGAAATTACTTTCATCCCTAAAAACCGTAACAGTATTTAATATGTTGTGGATAGCCTTAACGTTTGGCATGAATCATGAGCCTCCTTAACTGACTCTTCCAAACAAACAGCAATGTTCGCATCAAAGACAAGCTACTTTATCTTTCCTTTGTGAGGTTTTAGGCATTACTGAACAGAAAGCCCTGTCTGCTTTACATATTATATATCGTGTTTTTGTTCGTTTTCCTAGGGTATAAGCTTTGAATTGGAAGTAGTCCTGTAATATAGTTTATATTTCATAACTAAAGATGTGATAGAAGGATT...
pathogenic
91,894
Benign or pathogenic: chromosome 5, position 37010067, gene NIPBL (NIPBL cohesin loading factor) variant? Disease(s) if pathogenic?
benign
GGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTAAGTATAATCAATTTGTATTTTTAGTTACCCCACAAATAAAACAATATTGATGTCATTTAATCCAAATTTCCAAAAAATAATGAAGATACCTGGTTTTCAGTACATTCATTTCAATCTAAGGACTATTTTACTAAGTCTTATTAGACTTTATTAATTGAGGATTTATTTTTCTGTTTGGTTAATTTGTTGGGTTATTCTGTTTTTGTCACATTTAAAACACTTCCAAATATTTGCAAATATTTCAGCT...
GGGAATAACACCATTTTTTGTGGAAAATGTCAGTGAACTACAGTTGTGTGCCATTAAGTTAGTCACTGCAGTAAGTATAATCAATTTGTATTTTTAGTTACCCCACAAATAAAACAATATTGATGTCATTTAATCCAAATTTCCAAAAAATAATGAAGATACCTGGTTTTCAGTACATTCATTTCAATCTAAGGACTATTTTACTAAGTCTTATTAGACTTTATTAATTGAGGATTTATTTTTCTGTTTGGTTAATTTGTTGGGTTATTCTGTTTTTGTCACATTTAAAACACTTCCAAATATTTGCAAATATTTCAGCT...
benign
91,905
Regarding the variant found on chromosome 5 at position 37016150 in gene NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Inborn_genetic_diseases']
CAAGCTGAGGCAGGAGAATCAGGCAGGGAGGTTGCAGTGAGCCGAGATGGCAGCAGTACCGTCCAGCTTCGGCTCGGCATCAGAGGGAGACCGTGGAAAGAGAGGGAGAGGGAGACCGTGGAGAGGGAGAGGGAGAGGGAGAAGGAGAGGGAGAGGGAGGGAGAGCTTAATCTTTAAATTTCTGATGAAGGCTTTGAATTTTTTTTTTTGATTGTATGGATTATATGTTTCTTAAACTTTGAGGTTGACATATTTTTTCTAAATTCTTTTTTTATTTTCAATCCATTTCTTTCTGTTCTGACCAGGATTATGATAAACAA...
CAAGCTGAGGCAGGAGAATCAGGCAGGGAGGTTGCAGTGAGCCGAGATGGCAGCAGTACCGTCCAGCTTCGGCTCGGCATCAGAGGGAGACCGTGGAAAGAGAGGGAGAGGGAGACCGTGGAGAGGGAGAGGGAGAGGGAGAAGGAGAGGGAGAGGGAGGGAGAGCTTAATCTTTAAATTTCTGATGAAGGCTTTGAATTTTTTTTTTTGATTGTATGGATTATATGTTTCTTAAACTTTGAGGTTGACATATTTTTTCTAAATTCTTTTTTTATTTTCAATCCATTTCTTTCTGTTCTGACCAGGATTATGATAAACAA...
pathogenic
91,913
Determine whether the variant at chromosome 5, position 37017023, in gene NIPBL (NIPBL cohesin loading factor) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TTTTGTGAATTTGCTTATATGTTAGACTCCAGAAATTAAAGTACTAGATTGAAATTCTGTAATTTGTCTTCAGTAAATTTTGGAGAATTTTCCTAGTGTACCTGAATAGGAAAGTTTGTGAAGAGATGTTATTTAGCCTCCATATGAATTTTTTTTTTTTTTTAATGAGACAGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTAACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCCGGGATTACAGGCATGCACCACCATGGCCAGCTAATTTT...
TTTTGTGAATTTGCTTATATGTTAGACTCCAGAAATTAAAGTACTAGATTGAAATTCTGTAATTTGTCTTCAGTAAATTTTGGAGAATTTTCCTAGTGTACCTGAATAGGAAAGTTTGTGAAGAGATGTTATTTAGCCTCCATATGAATTTTTTTTTTTTTTTAATGAGACAGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTAACTGCAACCTCCGCCTCCCAGCTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCCGGGATTACAGGCATGCACCACCATGGCCAGCTAATTTT...
pathogenic
91,915
Assess the variant on chromosome 5, position 37022033, impacting NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
benign
AAAGGAACAGATTTACAGGTGTGTCTCAGTGTTAAACTATTTCAGTGACAATTGTCTTGTGTGTTTCTTGGAGAACTAAGGCAAAATTTGAAAACAGATGAAGTCTTCTACCTTCAGCATTTTATCAATTTGTTTTAAACTTTCCTAGTTGACCCATCATCTGTTTAACTTTGTCATGATGTTGTCCTTGATTAAGTAGTTGATAATAGTATTCTATATTTAATACAGTTGTGTTTATCAAATTATCTTGACTTCATTAATATAAGTATTGGAACATAGTAAAATAATAAGTTTTCTAACATTTAGGATATTCTATATTT...
AAAGGAACAGATTTACAGGTGTGTCTCAGTGTTAAACTATTTCAGTGACAATTGTCTTGTGTGTTTCTTGGAGAACTAAGGCAAAATTTGAAAACAGATGAAGTCTTCTACCTTCAGCATTTTATCAATTTGTTTTAAACTTTCCTAGTTGACCCATCATCTGTTTAACTTTGTCATGATGTTGTCCTTGATTAAGTAGTTGATAATAGTATTCTATATTTAATACAGTTGTGTTTATCAAATTATCTTGACTTCATTAATATAAGTATTGGAACATAGTAAAATAATAAGTTTTCTAACATTTAGGATATTCTATATTT...
benign
91,925
Mutation found at chromosome 5 position 37022108, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
CTAAGGCAAAATTTGAAAACAGATGAAGTCTTCTACCTTCAGCATTTTATCAATTTGTTTTAAACTTTCCTAGTTGACCCATCATCTGTTTAACTTTGTCATGATGTTGTCCTTGATTAAGTAGTTGATAATAGTATTCTATATTTAATACAGTTGTGTTTATCAAATTATCTTGACTTCATTAATATAAGTATTGGAACATAGTAAAATAATAAGTTTTCTAACATTTAGGATATTCTATATTTTCTGGCTTTCTTAAAATCTGTTTTTATCACATGGAAGTTGTTTTAAAGTAAACTTTAATATTTGTATTCCTGTAA...
CTAAGGCAAAATTTGAAAACAGATGAAGTCTTCTACCTTCAGCATTTTATCAATTTGTTTTAAACTTTCCTAGTTGACCCATCATCTGTTTAACTTTGTCATGATGTTGTCCTTGATTAAGTAGTTGATAATAGTATTCTATATTTAATACAGTTGTGTTTATCAAATTATCTTGACTTCATTAATATAAGTATTGGAACATAGTAAAATAATAAGTTTTCTAACATTTAGGATATTCTATATTTTCTGGCTTTCTTAAAATCTGTTTTTATCACATGGAAGTTGTTTTAAAGTAAACTTTAATATTTGTATTCCTGTAA...
pathogenic
91,928
Variant on chromosome 5, at position 37024698, affecting NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
GTAGATGATAGGAACCACATGGGGTAGTTAAATGTTTTTGAACAAGAATCTAGAGTGATTTTATGTATATATTTATGTATGTATATATATAAACAGGAAGAATTATTTCAGTGAGAGACACGTACAGAACGTTGGTACCTGACAATATTTTTGGATCCCTTAGGTGCATCTTCTTGTTTCCTTAAAGCTGATTAATGATAGCTCAGATACCTACAAGTTAAGCCCAAAAGTCCATTGAGGTTTAAGAGCAAACTAAAGAGGTTCTACATACATCATGGAATTCTCTGGCTCTGAAGCATTTTTCTGAAAAATGAAAGGAA...
GTAGATGATAGGAACCACATGGGGTAGTTAAATGTTTTTGAACAAGAATCTAGAGTGATTTTATGTATATATTTATGTATGTATATATATAAACAGGAAGAATTATTTCAGTGAGAGACACGTACAGAACGTTGGTACCTGACAATATTTTTGGATCCCTTAGGTGCATCTTCTTGTTTCCTTAAAGCTGATTAATGATAGCTCAGATACCTACAAGTTAAGCCCAAAAGTCCATTGAGGTTTAAGAGCAAACTAAAGAGGTTCTACATACATCATGGAATTCTCTGGCTCTGAAGCATTTTTCTGAAAAATGAAAGGAA...
pathogenic
91,938
A genetic alteration at chromosome 5, position 37036347, in gene NIPBL (NIPBL cohesin loading factor)—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
GAAAAATGATTTCATAAAATTATCTCATAAAAGCATTATCTTGTGAAGTTGAACAATGCATGTATCCAATGACCCAGCAATTCGACTTCAAATATATATACACACAAAAGAATCTTGCATATTTGCATCAGGAGGCATATACAAGAGTGCTTATTGTACTAAAATTGGGATTAACCTATCTACAAAAGAGTGGATAAATGAATTAAGGTATAGGCACACAGTGGGGTGTTGTACAGCAGAGAAAATCAGTAAAATACAGCTGTATGCAGTAACCTAGATCATAGTGGCATAATGATGAGTGAAAAAAGCAAATCTCAGAA...
GAAAAATGATTTCATAAAATTATCTCATAAAAGCATTATCTTGTGAAGTTGAACAATGCATGTATCCAATGACCCAGCAATTCGACTTCAAATATATATACACACAAAAGAATCTTGCATATTTGCATCAGGAGGCATATACAAGAGTGCTTATTGTACTAAAATTGGGATTAACCTATCTACAAAAGAGTGGATAAATGAATTAAGGTATAGGCACACAGTGGGGTGTTGTACAGCAGAGAAAATCAGTAAAATACAGCTGTATGCAGTAACCTAGATCATAGTGGCATAATGATGAGTGAAAAAAGCAAATCTCAGAA...
benign
91,945
Chromosome 5, position 37036347, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
GAAAAATGATTTCATAAAATTATCTCATAAAAGCATTATCTTGTGAAGTTGAACAATGCATGTATCCAATGACCCAGCAATTCGACTTCAAATATATATACACACAAAAGAATCTTGCATATTTGCATCAGGAGGCATATACAAGAGTGCTTATTGTACTAAAATTGGGATTAACCTATCTACAAAAGAGTGGATAAATGAATTAAGGTATAGGCACACAGTGGGGTGTTGTACAGCAGAGAAAATCAGTAAAATACAGCTGTATGCAGTAACCTAGATCATAGTGGCATAATGATGAGTGAAAAAAGCAAATCTCAGAA...
GAAAAATGATTTCATAAAATTATCTCATAAAAGCATTATCTTGTGAAGTTGAACAATGCATGTATCCAATGACCCAGCAATTCGACTTCAAATATATATACACACAAAAGAATCTTGCATATTTGCATCAGGAGGCATATACAAGAGTGCTTATTGTACTAAAATTGGGATTAACCTATCTACAAAAGAGTGGATAAATGAATTAAGGTATAGGCACACAGTGGGGTGTTGTACAGCAGAGAAAATCAGTAAAATACAGCTGTATGCAGTAACCTAGATCATAGTGGCATAATGATGAGTGAAAAAAGCAAATCTCAGAA...
benign
91,946
Variant on chromosome 5, at position 37048558, affecting NIPBL (NIPBL cohesin loading factor): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TAAAGAAAAATAATATAGAAGAATTCTGTGCTCTTTGCATTTTTTTAATTGTTCTTTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCT...
TAAAGAAAAATAATATAGAAGAATTCTGTGCTCTTTGCATTTTTTTAATTGTTCTTTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCT...
pathogenic
91,960
A genetic variant at chromosome 5, position 37048587, affecting gene NIPBL (NIPBL cohesin loading factor)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Cornelia_de_Lange_syndrome_1', 'Inborn_genetic_diseases']
GCTCTTTGCATTTTTTTAATTGTTCTTTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAG...
GCTCTTTGCATTTTTTTAATTGTTCTTTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAG...
pathogenic
91,961
Does the chromosome 5 mutation at position 37048613 within gene NIPBL (NIPBL cohesin loading factor) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAGAACAGTCTGTCCAGGTTTTTGGTTTT...
TTTTCATTGCAAAGCTTTGTCACTACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAGAACAGTCTGTCCAGGTTTTTGGTTTT...
pathogenic
91,963
Located at chromosome 5 position 37048636, the variant affecting gene NIPBL (NIPBL cohesin loading factor)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Cornelia_de_Lange_syndrome_1', 'NIPBL-related_disorder']
TACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAGAACAGTCTGTCCAGGTTTTTGGTTTTTGTTGTTGTTTTTTTTGGTACAA...
TACAGGAAGCTGCCACATCTGGTTAAAACAATGATCAGTCTACACTGACTTATTTATATAAAAGCAAATAGTAAGCAACCCAGAAGGAACAATTTGGATATATACCTGTTTTATAATGTTTTTCCAGGAAGGATTGATGTAATAAAAACATGTTTTGCAATTGTTAGGCAGGTCTATGTGGCTTATATCTAGGAAGGAATTAGAATATGAGGAAATAGGAGGTGAATGGCATTAAAGTACCTGAATTGAATGCACTTCAAAAAAATACAAGAACAGTCTGTCCAGGTTTTTGGTTTTTGTTGTTGTTTTTTTTGGTACAA...
pathogenic
91,964
Clinical classification of chromosome 5, position 37051759, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? Disease(s) if pathogenic?
benign
TTCATCTTTAAGTTGGGTATAACACCAACTACTCGACACCTCATAGCATTAATATGAGGACACAACGACGTAATAAAGACATTAGTGTTACTGAAGATTGGCAGCCAATGCTGATGTAGTAGTATATACCATCTGATGGTCAAGAGAGCACCATAGGCTACAAAAGTGTATGTATTAAGTAAGCAGAGTCTATACCCTTCAAGATTTTTATTTTGGGTATTTTTCATGGAACGTTTTAAAAATATGATTTATTTAAACATACTGTGGTCTTCCCTGTGTCCTGAAACAAAACATGTTAACAAATATTTATCCTGTTCTTC...
TTCATCTTTAAGTTGGGTATAACACCAACTACTCGACACCTCATAGCATTAATATGAGGACACAACGACGTAATAAAGACATTAGTGTTACTGAAGATTGGCAGCCAATGCTGATGTAGTAGTATATACCATCTGATGGTCAAGAGAGCACCATAGGCTACAAAAGTGTATGTATTAAGTAAGCAGAGTCTATACCCTTCAAGATTTTTATTTTGGGTATTTTTCATGGAACGTTTTAAAAATATGATTTATTTAAACATACTGTGGTCTTCCCTGTGTCCTGAAACAAAACATGTTAACAAATATTTATCCTGTTCTTC...
benign
91,968
A mutation at chromosome position 37058913 on chromosome 5 in gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Cornelia_de_Lange_syndrome_1', 'NIPBL-related_disorder']
CTCTTGAGATAGCATAGTGTAAGTCATTATAAAATTAAAAAAAATGGGCCTAAGATTATTTTATAAAATTCCATTTCTGTTCCCCCTTTTCCCTTTTTGTTACACCTGTCTCCCTTTCCCTTTTTCCCCCCTCTATATTTCTCTCCCTCCTCCTCTCCCTCTGTCTCTCTGTGTCTCTCCCCACTCTCTCCGTGTGTGTCTGCTTATCTCTGTCTAACATTAAGTGAGGTGAAAGTGCCCTGTATTTTTTCTAAAAAAGGTTTTTTGGTTGGGTTTCTAGATTATCCGCTAAACATGTGTGCTTTTTCTTAAAATTTACA...
CTCTTGAGATAGCATAGTGTAAGTCATTATAAAATTAAAAAAAATGGGCCTAAGATTATTTTATAAAATTCCATTTCTGTTCCCCCTTTTCCCTTTTTGTTACACCTGTCTCCCTTTCCCTTTTTCCCCCCTCTATATTTCTCTCCCTCCTCCTCTCCCTCTGTCTCTCTGTGTCTCTCCCCACTCTCTCCGTGTGTGTCTGCTTATCTCTGTCTAACATTAAGTGAGGTGAAAGTGCCCTGTATTTTTTCTAAAAAAGGTTTTTTGGTTGGGTTTCTAGATTATCCGCTAAACATGTGTGCTTTTTCTTAAAATTTACA...
pathogenic
91,979
Does the variant impacting NIPBL (NIPBL cohesin loading factor) on chromosome 5, position 37060945, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Cornelia_de_Lange_syndrome_1', 'NIPBL-related_disorder']
GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGGTAAGGTTACATAAGCAGTGAGAGAAAAAACTTCACTCTGTTCAAATAATA...
GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGGTAAGGTTACATAAGCAGTGAGAGAAAAAACTTCACTCTGTTCAAATAATA...
pathogenic
91,982
Evaluate this variant at chromosome 5, position 37064796, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Cornelia_de_Lange_syndrome_1']
TGTCTCTACAAAAAATACAAACATTAGCCAGACATGGCGGTGTGCACCTGTAGTCCCAACTGCTGGGGAGGCTGAGGTGGGAGGACCACCTAAGCCTGGGAGGTGGAGGCTACAGTGAGCCATGATCGTGCCACTGCACTTCAGCCTGAGTGACAGAGTGAGACCCTGTCTCAATTTAAAAAGAAAAAAAAAAAGGGTTAAGCTGGCAAATTTTATGATATTTCTATTTTATCACAATATAAAAGTTTTTAAAAATGTTTTTGAAATTAGAGGACTATCCTAAAAAATAAAAATAAAGTTTTATATTTTAATCTACTTAA...
TGTCTCTACAAAAAATACAAACATTAGCCAGACATGGCGGTGTGCACCTGTAGTCCCAACTGCTGGGGAGGCTGAGGTGGGAGGACCACCTAAGCCTGGGAGGTGGAGGCTACAGTGAGCCATGATCGTGCCACTGCACTTCAGCCTGAGTGACAGAGTGAGACCCTGTCTCAATTTAAAAAGAAAAAAAAAAAGGGTTAAGCTGGCAAATTTTATGATATTTCTATTTTATCACAATATAAAAGTTTTTAAAAATGTTTTTGAAATTAGAGGACTATCCTAAAAAATAAAAATAAAGTTTTATATTTTAATCTACTTAA...
pathogenic
91,990
Clinical significance of chromosome 5, position 37064967, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? Name the disease(s) if pathogenic.
benign
CAATTTAAAAAGAAAAAAAAAAAGGGTTAAGCTGGCAAATTTTATGATATTTCTATTTTATCACAATATAAAAGTTTTTAAAAATGTTTTTGAAATTAGAGGACTATCCTAAAAAATAAAAATAAAGTTTTATATTTTAATCTACTTAATTTCAGGTGTAGTGGCTCACAAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTCGAGGCCAGAGGTTTGACACCAGTTTGGCCAACATTGCAAAACCCCATTTCTATTTTTCTTAAAAAAATTTTTAAAAATCTACTTTAAAGCAAGTAGCTGAACATAAAATAAGGTTT...
CAATTTAAAAAGAAAAAAAAAAAGGGTTAAGCTGGCAAATTTTATGATATTTCTATTTTATCACAATATAAAAGTTTTTAAAAATGTTTTTGAAATTAGAGGACTATCCTAAAAAATAAAAATAAAGTTTTATATTTTAATCTACTTAATTTCAGGTGTAGTGGCTCACAAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTCGAGGCCAGAGGTTTGACACCAGTTTGGCCAACATTGCAAAACCCCATTTCTATTTTTCTTAAAAAAATTTTTAAAAATCTACTTTAAAGCAAGTAGCTGAACATAAAATAAGGTTT...
benign
91,994
Clinical classification of chromosome 5, position 37065171, gene NIPBL (NIPBL cohesin loading factor): benign or pathogenic? Disease(s) if pathogenic?
benign
GAGGCCAGAGGTTTGACACCAGTTTGGCCAACATTGCAAAACCCCATTTCTATTTTTCTTAAAAAAATTTTTAAAAATCTACTTTAAAGCAAGTAGCTGAACATAAAATAAGGTTTTTTGAACTAAGAATATAATCTACACAGTGGCTTTTCATATTATTCATTGACTGCAAACCTTACTCTAAAATTTAAAAATATTTTAGTTCTTATTTAAAATTTTTCAACATTCTTTGCTTTCTCTTGTATCGTCTTAGCAGAGAGCAAAGAGGGGAGATAACTAGAAAATGTCTATCAGTAATTATCACCTGATTGCTTGATGAC...
GAGGCCAGAGGTTTGACACCAGTTTGGCCAACATTGCAAAACCCCATTTCTATTTTTCTTAAAAAAATTTTTAAAAATCTACTTTAAAGCAAGTAGCTGAACATAAAATAAGGTTTTTTGAACTAAGAATATAATCTACACAGTGGCTTTTCATATTATTCATTGACTGCAAACCTTACTCTAAAATTTAAAAATATTTTAGTTCTTATTTAAAATTTTTCAACATTCTTTGCTTTCTCTTGTATCGTCTTAGCAGAGAGCAAAGAGGGGAGATAACTAGAAAATGTCTATCAGTAATTATCACCTGATTGCTTGATGAC...
benign
91,995
Evaluate the clinical significance of the mutation at chromosome 5, position 37108430 in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
ATCCCAATTACCCTGATTTGATTGCTACACATTGTATGCACATATCAAAATATCACATGCACCCCATAAAAATGTACAACTATCATGTATCAATAAAATACCCATAGAATATACAAAAAAGAAACTAACAGAAAACAATTTAAAATATTTTAAATGACAAAACAATTAAATGACAATTAACAATAATGTTAGCCTATAAAGCTATTTTCTAAAACAATTTGGTAAGGAGAGTAGCATTGTTTTATAGTTCTACAAATCTCTTTAATGTTTAGCTTGATAGAAGGCAGCTGAATTACCATACCTGCTTCTGCATTCAACTT...
ATCCCAATTACCCTGATTTGATTGCTACACATTGTATGCACATATCAAAATATCACATGCACCCCATAAAAATGTACAACTATCATGTATCAATAAAATACCCATAGAATATACAAAAAAGAAACTAACAGAAAACAATTTAAAATATTTTAAATGACAAAACAATTAAATGACAATTAACAATAATGTTAGCCTATAAAGCTATTTTCTAAAACAATTTGGTAAGGAGAGTAGCATTGTTTTATAGTTCTACAAATCTCTTTAATGTTTAGCTTGATAGAAGGCAGCTGAATTACCATACCTGCTTCTGCATTCAACTT...
pathogenic
91,997
Does the chromosome 5 mutation at position 37139372 within gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
TTATTGTCCATATTGCTATCAGGCTTTTGGTCAAAGCCATTCAACAAGTCTCTAGGAAGTTCCAAACTTTCCCACATCTTCCTGTCTTCTTCTGAGTCCTACAAACTGTTCCAACCTCTGCCTGTTACCCAGTTCCAAAGTCGCTTCCACATTTTCAGGTATTTTTACAGTAGCACCCCACTCTCTGCAGCACCAATTTACTATATTAGTCTGTTCTTACACTGCTAAATAAGACATACCTGAGACTGAACAATTTATAAACGAAAGAGGTGTAATTAACTCACAGTTCAGCATGGCTGGGGAGGCCTCAGGAAACTTAC...
TTATTGTCCATATTGCTATCAGGCTTTTGGTCAAAGCCATTCAACAAGTCTCTAGGAAGTTCCAAACTTTCCCACATCTTCCTGTCTTCTTCTGAGTCCTACAAACTGTTCCAACCTCTGCCTGTTACCCAGTTCCAAAGTCGCTTCCACATTTTCAGGTATTTTTACAGTAGCACCCCACTCTCTGCAGCACCAATTTACTATATTAGTCTGTTCTTACACTGCTAAATAAGACATACCTGAGACTGAACAATTTATAAACGAAAGAGGTGTAATTAACTCACAGTTCAGCATGGCTGGGGAGGCCTCAGGAAACTTAC...
benign
92,021
Regarding the variant at chromosome 5 and position 37148216, affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['CPLANE1-related_disorder', 'Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
pathogenic
92,028
The genetic variant at chromosome 5, position 37148216, affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Global_developmental_delay', 'Jaundice', 'Joubert_syndrome_17']
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
pathogenic
92,029
Variant at chromosome 5, position 37148216, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Inborn_genetic_diseases', 'Joubert_syndrome_and_related_disorders']
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
GTAATAATTAAAAAGCTTTTTTTTTTTTCGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGACTCACTGCAAGCTCCGCCTCCTGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGACTACAGGCACCCGCCACCACACCAGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATATTGGCCAGGCTGGTTTCGAACTCCTGATCTTGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGCCTAAAAGACTAT...
pathogenic
92,030
Mutation found at chromosome 5 position 37153961, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Global_developmental_delay', 'Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6', 'Typical_Joubert_syndrome_MRI_findings']
ATAAGCATCATAGTATCATTACTTAGTATTAATATTTTTAGCAGTAGTCCTGCCTCATAACCTTTCAGTATAGTTTCACATATGCTTAATCTTTATTTTTAAATGTGTTAAATGTTTGGATTAAAGGTGTACTATAAACCTAATAAATACATTTTTTAAATGTCAACATGCTAGCAACCTGGAATTTTTGTAAGGTAAGTCAATAATGGAATTCTTATCCTGCAGACTATTTTGCATTTCCCAATATTAGACTTTAAGACATTTAACTTTGTTTTTTTTTAAGAGGCAGGGTCTTGCTCTGACACCCAGGCTACAGTGCA...
ATAAGCATCATAGTATCATTACTTAGTATTAATATTTTTAGCAGTAGTCCTGCCTCATAACCTTTCAGTATAGTTTCACATATGCTTAATCTTTATTTTTAAATGTGTTAAATGTTTGGATTAAAGGTGTACTATAAACCTAATAAATACATTTTTTAAATGTCAACATGCTAGCAACCTGGAATTTTTGTAAGGTAAGTCAATAATGGAATTCTTATCCTGCAGACTATTTTGCATTTCCCAATATTAGACTTTAAGACATTTAACTTTGTTTTTTTTTAAGAGGCAGGGTCTTGCTCTGACACCCAGGCTACAGTGCA...
pathogenic
92,036
Variant chromosome 5, position 37157657, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? Disease(s)?
benign
AAGAAATCCACCCGCCTTAGCCTCCCAAAGTGTTGGGATTATAGGCGTGAGCCACCACACCCAGCCAAACTTTAATTTTCTCAAACTAAGCAAGTTCCATTAACTTACTGCAAAATCTATTCTCTCTGTCTGATAAATGAAATTAATCTGTAGCTTATGGTCATTTGAAATGCTGGCCTAACATACTCAGGGGTCACAGAGAGAAAAGTAAAACGTATCTAAGCTATTAAATGACAGAGCTGGGATTCAAATCCAGGTCTGTTCTATGTGAATCTAAAAGCCAGGCTCCTTTCACTTTCCCACATACTTCCCCTGTCTGA...
AAGAAATCCACCCGCCTTAGCCTCCCAAAGTGTTGGGATTATAGGCGTGAGCCACCACACCCAGCCAAACTTTAATTTTCTCAAACTAAGCAAGTTCCATTAACTTACTGCAAAATCTATTCTCTCTGTCTGATAAATGAAATTAATCTGTAGCTTATGGTCATTTGAAATGCTGGCCTAACATACTCAGGGGTCACAGAGAGAAAAGTAAAACGTATCTAAGCTATTAAATGACAGAGCTGGGATTCAAATCCAGGTCTGTTCTATGTGAATCTAAAAGCCAGGCTCCTTTCACTTTCCCACATACTTCCCCTGTCTGA...
benign
92,039
Mutation at chromosome 5, position 37168991, within CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
TTGTGTATAGCCTAGGAGACTGAACCAGATTACTGTGTGATTATAAATAATAATGAACTTGCTGATATATGATATTATCAAATAAAATTTCACTTAAGCCTTGCCTTTTTTTACTGTCCTTTCCTTGTCTTACTTCAGGTGGTTCTATTTTGACCTTTAGAAGTTGAAGGTGTCCAGCATCACCTTGTTCAAATAAATTATGTGTTAGTTTCTGTTGGCTTTGTTTAAACGCAATGAGGTTTTCAAGTGGGATAAGTTGTGTTTTTTTGCACTACAAGAAAGAAACAAAGCATAAGAATGACAAATTGCAAACTCAATTA...
TTGTGTATAGCCTAGGAGACTGAACCAGATTACTGTGTGATTATAAATAATAATGAACTTGCTGATATATGATATTATCAAATAAAATTTCACTTAAGCCTTGCCTTTTTTTACTGTCCTTTCCTTGTCTTACTTCAGGTGGTTCTATTTTGACCTTTAGAAGTTGAAGGTGTCCAGCATCACCTTGTTCAAATAAATTATGTGTTAGTTTCTGTTGGCTTTGTTTAAACGCAATGAGGTTTTCAAGTGGGATAAGTTGTGTTTTTTTGCACTACAAGAAAGAAACAAAGCATAAGAATGACAAATTGCAAACTCAATTA...
pathogenic
92,061
Does the chromosome 5 mutation at position 37169546 within gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GCCAAGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGACGGGCTGATCACAAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCCCTACTAAAGATATAAAAAATTATCCAGGCATTGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGTTGGAGGTTGCAGTGAGCTGAGATGGCGCCATTACACTCCAGCCTGGTGACAGGGCAAGGCTCCGTCTCATACATAAAAACAAAAAAAACCTTTCCTCTTATAAATGAAA...
GCCAAGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGTCGAGACGGGCTGATCACAAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCCCTACTAAAGATATAAAAAATTATCCAGGCATTGTGGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGTTGGAGGTTGCAGTGAGCTGAGATGGCGCCATTACACTCCAGCCTGGTGACAGGGCAAGGCTCCGTCTCATACATAAAAACAAAAAAAACCTTTCCTCTTATAAATGAAA...
pathogenic
92,067
Is the chromosome 5, position 37170148 variant in CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GTACTGCTCTCCTCAAAACTAGAGCCTAAACCATTTTAATTTCATAAATCAAAAGTTATACCTTTAAAGAGGACTTGGTGGGTTTATAAAACTACCATTTTAATATATATGCTACTAATCACAGATTCTGGGTCTATTTAACAAATTTAACCTGTCAAAGATTTGAAGATCATACAATAATTGCTAGGAACCTCAAACAATATGTGTGCTCACTTGCTCTCCACTCTACACACACATAAACAAGAGCATCTGGTAATTTTTTTGCTTTCTTTTTTGAGTGTTTAAATCTGACACAGAGTACCTGGTAATTTTACTTCTTA...
GTACTGCTCTCCTCAAAACTAGAGCCTAAACCATTTTAATTTCATAAATCAAAAGTTATACCTTTAAAGAGGACTTGGTGGGTTTATAAAACTACCATTTTAATATATATGCTACTAATCACAGATTCTGGGTCTATTTAACAAATTTAACCTGTCAAAGATTTGAAGATCATACAATAATTGCTAGGAACCTCAAACAATATGTGTGCTCACTTGCTCTCCACTCTACACACACATAAACAAGAGCATCTGGTAATTTTTTTGCTTTCTTTTTTGAGTGTTTAAATCTGACACAGAGTACCTGGTAATTTTACTTCTTA...
pathogenic
92,072
Gene mutation in CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) at chromosome 5, position 37170232—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Joubert_syndrome_17']
TATAAAACTACCATTTTAATATATATGCTACTAATCACAGATTCTGGGTCTATTTAACAAATTTAACCTGTCAAAGATTTGAAGATCATACAATAATTGCTAGGAACCTCAAACAATATGTGTGCTCACTTGCTCTCCACTCTACACACACATAAACAAGAGCATCTGGTAATTTTTTTGCTTTCTTTTTTGAGTGTTTAAATCTGACACAGAGTACCTGGTAATTTTACTTCTTATTTCTTCCCAGAGCAGCAGAAATATTTATGAAAGAGTCCAGTAAATTCCAGTATTGATAGAAAGACCTAAAACCTTTAAAATAC...
TATAAAACTACCATTTTAATATATATGCTACTAATCACAGATTCTGGGTCTATTTAACAAATTTAACCTGTCAAAGATTTGAAGATCATACAATAATTGCTAGGAACCTCAAACAATATGTGTGCTCACTTGCTCTCCACTCTACACACACATAAACAAGAGCATCTGGTAATTTTTTTGCTTTCTTTTTTGAGTGTTTAAATCTGACACAGAGTACCTGGTAATTTTACTTCTTATTTCTTCCCAGAGCAGCAGAAATATTTATGAAAGAGTCCAGTAAATTCCAGTATTGATAGAAAGACCTAAAACCTTTAAAATAC...
pathogenic
92,074
Regarding the variant found on chromosome 5 at position 37177648 in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
CAGTTAGAAGCTGAAAATGAGCAACAACTTCATCTTTCAATAATATATCACTACTTTTTTTCAGAAAAGACTGTTCAACATAGTTCCTGTGTAACTTTAAAATACAATCGCTAGTGGAAACTCAGTAATGAAAGATGTCAGATCTGTGTGCTTATGCTGCTCTTTCAATGTTTTATGTTGCTTTCATTTTTCTTAGTTTTTAGTCAAAATGTAGCAATTGTTTCAAAAATGGTACAGTCGGCATACTTTCACTCTGTGATTTGTAAAACACAACTATTTTTAAATGGTATAGTAGGCAAAACTTCTTACCTAGAAATTTC...
CAGTTAGAAGCTGAAAATGAGCAACAACTTCATCTTTCAATAATATATCACTACTTTTTTTCAGAAAAGACTGTTCAACATAGTTCCTGTGTAACTTTAAAATACAATCGCTAGTGGAAACTCAGTAATGAAAGATGTCAGATCTGTGTGCTTATGCTGCTCTTTCAATGTTTTATGTTGCTTTCATTTTTCTTAGTTTTTAGTCAAAATGTAGCAATTGTTTCAAAAATGGTACAGTCGGCATACTTTCACTCTGTGATTTGTAAAACACAACTATTTTTAAATGGTATAGTAGGCAAAACTTCTTACCTAGAAATTTC...
pathogenic
92,082
Gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) variant at chromosome position 37180085 on chromosome 5: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
CTTTTTTGAAAGAATTGTTACAAGGCAGGCAGATCTACTTGAGGTCAGGAGCTCAAGATCAGCCTGGCCAACATGGTGAAACTCTGTCTCTATAAAAAAATACAAAAAATTAGTCAGGCATGGTGGCGCATACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAACCTGGGAGGTGGAAGCTGCAGTTAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTCTCAAAAATAAAAATAAAAATAAAAATAAAAAAGAATTGTTACAACAGATAGGGCACGGTGGCTCACACC...
CTTTTTTGAAAGAATTGTTACAAGGCAGGCAGATCTACTTGAGGTCAGGAGCTCAAGATCAGCCTGGCCAACATGGTGAAACTCTGTCTCTATAAAAAAATACAAAAAATTAGTCAGGCATGGTGGCGCATACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAACCTGGGAGGTGGAAGCTGCAGTTAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTCTCAAAAATAAAAATAAAAATAAAAATAAAAAAGAATTGTTACAACAGATAGGGCACGGTGGCTCACACC...
pathogenic
92,089
Does the variant on chromosome 5 at location 37180159 affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Orofaciodigital_syndrome_type_6']
GGTGAAACTCTGTCTCTATAAAAAAATACAAAAAATTAGTCAGGCATGGTGGCGCATACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAACCTGGGAGGTGGAAGCTGCAGTTAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTCTCAAAAATAAAAATAAAAATAAAAATAAAAAAGAATTGTTACAACAGATAGGGCACGGTGGCTCACACCTGTAATTTCAGCACTTTGAGAGGTTGAGGCTAGGAGTTCAAGACCAGCCTAAGCAACATAGCAAGGCCCAGTCT...
GGTGAAACTCTGTCTCTATAAAAAAATACAAAAAATTAGTCAGGCATGGTGGCGCATACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGAATTGCTTGAACCTGGGAGGTGGAAGCTGCAGTTAGCCAAGATCACACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTCTCAAAAATAAAAATAAAAATAAAAATAAAAAAGAATTGTTACAACAGATAGGGCACGGTGGCTCACACCTGTAATTTCAGCACTTTGAGAGGTTGAGGCTAGGAGTTCAAGACCAGCCTAAGCAACATAGCAAGGCCCAGTCT...
pathogenic
92,090
Clinically, how would you classify the variant at chromosome 5, position 37184871, gene CPLANE1: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
TGTAAGAATGGCAGCTGTAGAGGTCTTTACACGAATTACTGGACTGTACTCAGAGGATGACTCAGTTATACCAGAATCACAGAGTAGCCTTCTATTAGACCACCTTATCATCCATTCCAGCAGTCTTCCTATACTGCCAAAAGTGTTTAGTGCTAAAGGAAGATCTTCTTGAGGGTTAATATCATTGCACTGAATAGCTTTGAAAATACATCTTCTAGTTTTAATGGACTTGGGAGTCCAAAAAATGTGGTTTGATGATCTCTGGATTAGACATTTCTCTCTAGTGTCATCTTGTATTTTGTAAATTGACCTTTGTTTTA...
TGTAAGAATGGCAGCTGTAGAGGTCTTTACACGAATTACTGGACTGTACTCAGAGGATGACTCAGTTATACCAGAATCACAGAGTAGCCTTCTATTAGACCACCTTATCATCCATTCCAGCAGTCTTCCTATACTGCCAAAAGTGTTTAGTGCTAAAGGAAGATCTTCTTGAGGGTTAATATCATTGCACTGAATAGCTTTGAAAATACATCTTCTAGTTTTAATGGACTTGGGAGTCCAAAAAATGTGGTTTGATGATCTCTGGATTAGACATTTCTCTCTAGTGTCATCTTGTATTTTGTAAATTGACCTTTGTTTTA...
pathogenic
92,109
The mutation in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) at chromosome 5, position 37185087—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
AGTTTTAATGGACTTGGGAGTCCAAAAAATGTGGTTTGATGATCTCTGGATTAGACATTTCTCTCTAGTGTCATCTTGTATTTTGTAAATTGACCTTTGTTTTAAACCAAATAATCCACTCATTCCTTCATTCTTATTGACTTCATTCGAAGGATATTGTAAAAAAGGTTTGATCCCTTGATTAACCAGTACTGATGATGAAAGTTTCTGGTTTTCTAAATGCATGCCATATTCATCATTTAAAGAGGATGATTTTTCTGATTCATAGGACTCAGGAGCAACAACAAAGCAAGAACCAGCTCTAAACACATTCTGGCTTT...
AGTTTTAATGGACTTGGGAGTCCAAAAAATGTGGTTTGATGATCTCTGGATTAGACATTTCTCTCTAGTGTCATCTTGTATTTTGTAAATTGACCTTTGTTTTAAACCAAATAATCCACTCATTCCTTCATTCTTATTGACTTCATTCGAAGGATATTGTAAAAAAGGTTTGATCCCTTGATTAACCAGTACTGATGATGAAAGTTTCTGGTTTTCTAAATGCATGCCATATTCATCATTTAAAGAGGATGATTTTTCTGATTCATAGGACTCAGGAGCAACAACAAAGCAAGAACCAGCTCTAAACACATTCTGGCTTT...
benign
92,113
Regarding the variant at chromosome 5 and position 37186319, affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Joubert_syndrome_17']
TTCTCAACATGATTCCTAGGGCAGAACACAGATCCTTAGTTCCCTCAGTAAGAGAACAGGTGTTGGCCACCTGGGCTGAAAGCATCCCATCCCTTCTGATTGAGGCAATTTCCTTCCCTGAAATATTTCCCTTAAAAATATTAAGGAAATTTAAGGAAAAATTTCCTTAAAAATAATATGGCTAACTCAGTAACCTCAAACTATTTAAGTCTAAAGATTACTAAAAAAAACTGAAAGTCCTCCAGTGAAGTGTAGAATTTCATCTACTCCTTTGATTTTATAATTTCAGATGGCAAAATTATTTCATATATCAATAATAC...
TTCTCAACATGATTCCTAGGGCAGAACACAGATCCTTAGTTCCCTCAGTAAGAGAACAGGTGTTGGCCACCTGGGCTGAAAGCATCCCATCCCTTCTGATTGAGGCAATTTCCTTCCCTGAAATATTTCCCTTAAAAATATTAAGGAAATTTAAGGAAAAATTTCCTTAAAAATAATATGGCTAACTCAGTAACCTCAAACTATTTAAGTCTAAAGATTACTAAAAAAAACTGAAAGTCCTCCAGTGAAGTGTAGAATTTCATCTACTCCTTTGATTTTATAATTTCAGATGGCAAAATTATTTCATATATCAATAATAC...
pathogenic
92,114
Is chromosome 5, position 37187824, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
TTTTAAATGGCTAAAATGGTAAATTTTATATTATATGCATTTTACCACAGTAAGAAATGTGTGTATTCTAATTTTGAAGAACAAAATTAGAAGCATAAATAACCATAAAGGGAAATTACTTGTTTTCAACAAATACTTGCAATATACAAAGTACCATATGCTCATTTTATATTATCTTACTTAATCCTCTCTGAATACACATCATAAAGCAGGTAATACTATGCCCACTTTACAAATAAAGATATGAGGCTCAGAGAGACTGAGCAACTTGCCTAAGATCGCACAGTTACTGACTGACAGAGCCATGAGCCGAAGTCAGC...
TTTTAAATGGCTAAAATGGTAAATTTTATATTATATGCATTTTACCACAGTAAGAAATGTGTGTATTCTAATTTTGAAGAACAAAATTAGAAGCATAAATAACCATAAAGGGAAATTACTTGTTTTCAACAAATACTTGCAATATACAAAGTACCATATGCTCATTTTATATTATCTTACTTAATCCTCTCTGAATACACATCATAAAGCAGGTAATACTATGCCCACTTTACAAATAAAGATATGAGGCTCAGAGAGACTGAGCAACTTGCCTAAGATCGCACAGTTACTGACTGACAGAGCCATGAGCCGAAGTCAGC...
pathogenic
92,121
Does the genetic variant at chromosome 5, position 37195999, impacting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
TCGTCCTGTCACCCAGGCTGGAGTACAATGGTGCAATCTTGGCTCACTGCAACCTCCATCTCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTCTCGAGTAGCTGGGATTACAGGTGCACACCACTATGCCTGGCTAATTTTTTGCATATTTTAGTAGAGACAGGGTTTTACCATGCTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCGCCCAACTCATCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAAAGGAAACTTTTTAATCTAGCCAAATCACTTCTCAACAATCAAGAG...
TCGTCCTGTCACCCAGGCTGGAGTACAATGGTGCAATCTTGGCTCACTGCAACCTCCATCTCCCAGGTTCAAGTGATTCTCCTGCTTCAGCCTCTCGAGTAGCTGGGATTACAGGTGCACACCACTATGCCTGGCTAATTTTTTGCATATTTTAGTAGAGACAGGGTTTTACCATGCTGGCCAGGCTGGTCTCGAACTCCTGACCTTGTGATCCGCCCAACTCATCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAGAAAGGAAACTTTTTAATCTAGCCAAATCACTTCTCAACAATCAAGAG...
benign
92,126
The chromosome 5, position 37198828 genetic variant in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
TTGGGCGAGGTGGCAGGCGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGCCGGAGGTTGCGGTGAGCCGAGACCATGCCACTGCACCCAGCCTGGGCGACAGAGTGAGATGCTGTCTCAAAAAAGAAAAAAGGAAAAAAAAAAAGAAAATTTGAACTCCAATCTATTTAAACCTCTCTACCTCAATGAGCACAGATTAATGACCGGGTTACAGGGGTAAAAAAAGGAAAGAGAAACAAGCTAAACGACACTAAATGAAGAAACGATCAGACAAATCTAGAATATGGTGCAGGAA...
TTGGGCGAGGTGGCAGGCGCCTGTAGTCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGCCGGAGGTTGCGGTGAGCCGAGACCATGCCACTGCACCCAGCCTGGGCGACAGAGTGAGATGCTGTCTCAAAAAAGAAAAAAGGAAAAAAAAAAAGAAAATTTGAACTCCAATCTATTTAAACCTCTCTACCTCAATGAGCACAGATTAATGACCGGGTTACAGGGGTAAAAAAAGGAAAGAGAAACAAGCTAAACGACACTAAATGAAGAAACGATCAGACAAATCTAGAATATGGTGCAGGAA...
pathogenic
92,130
Located at chromosome 5 position 37201690, the variant affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
CAGTAGCTAAAGATTATTTTCCCAGATAATGAGATAATGTGAGCATTGTAAACATCTGCTTCCCCAACATCCTTCTTCCCTGCCCACTTCTTAACAGTACTCAGTTTTTGAGTATCTGCCCATCTCCTACATGGCTCATATGATTGAGGGAAAGCTCATCCCACCTCAAGGAAGGATCTATTCACAGGCCAAGCAGTACCTTGTGTTAAGCCTAGCCACAGTGACTGTTTAAAGGACAGGCATGTGACCCAAGCCAGTCTCACTAAGAGTGAATCTCAATCCTCTTGCTTGGAATGCTGGGACAGAAATAATTTTGCCAC...
CAGTAGCTAAAGATTATTTTCCCAGATAATGAGATAATGTGAGCATTGTAAACATCTGCTTCCCCAACATCCTTCTTCCCTGCCCACTTCTTAACAGTACTCAGTTTTTGAGTATCTGCCCATCTCCTACATGGCTCATATGATTGAGGGAAAGCTCATCCCACCTCAAGGAAGGATCTATTCACAGGCCAAGCAGTACCTTGTGTTAAGCCTAGCCACAGTGACTGTTTAAAGGACAGGCATGTGACCCAAGCCAGTCTCACTAAGAGTGAATCTCAATCCTCTTGCTTGGAATGCTGGGACAGAAATAATTTTGCCAC...
pathogenic
92,135
Evaluate the clinical significance of the mutation at chromosome 5, position 37206215 in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['CPLANE1-related_disorder', 'Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GATTAAAGCAAAAGAACTGCACAGAAAATTATCAAAGAAAAGTTTATAGTCAGATTTCCAAGCATTATAGGTTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTT...
GATTAAAGCAAAAGAACTGCACAGAAAATTATCAAAGAAAAGTTTATAGTCAGATTTCCAAGCATTATAGGTTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTT...
pathogenic
92,145
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 5, position 37206250, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Familial_aplasia_of_the_vermis']
AGAAAAGTTTATAGTCAGATTTCCAAGCATTATAGGTTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGAT...
AGAAAAGTTTATAGTCAGATTTCCAAGCATTATAGGTTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGAT...
pathogenic
92,146
The mutation impacting CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) on chromosome 5 at position 37206286: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Joubert_syndrome_17', 'Joubert_syndrome_and_related_disorders']
TTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGATCTATAATTTATGCACTAGGTGAGAGTTGAAATAAAT...
TTCTCTCAAAACAGAAATGTTATAAGTTTTAGGAATCTAGAGTTAGAAGTCTCACTCTTTACTGGAGCAAAGCACCAATAAAAACAGAAGGGCCTCACAGTTGCCCTGGTTTTACATTAAATATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGATCTATAATTTATGCACTAGGTGAGAGTTGAAATAAAT...
pathogenic
92,147
The mutation impacting CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) on chromosome 5 at position 37206408: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Joubert_syndrome_17', 'Joubert_syndrome_and_related_disorders', 'Orofaciodigital_syndrome_type_6']
ATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGATCTATAATTTATGCACTAGGTGAGAGTTGAAATAAATCACTCCTAAGTACCCTTCCAGGCTTGAGATTCTACAGCTCCAAAAGAAAATGATACAAATGAAGCGAAATATAATTAGTGTAAAGGTATGTATGAAGGCTACTCTCAACATAGTCTCTGGGG...
ATACGACATTAAATGACTGATTTCATTACTTTTTATCTAAATTTCTCCAACTGTAAAACAGATAAATTTTATAGGATTCCTGTGTGAATCCATGTAATACATGTAATATTCTATCATTTTTAATTTTTTAATACCATTTTGAACTTTTCAAATAAAAAAGATCTATAATTTATGCACTAGGTGAGAGTTGAAATAAATCACTCCTAAGTACCCTTCCAGGCTTGAGATTCTACAGCTCCAAAAGAAAATGATACAAATGAAGCGAAATATAATTAGTGTAAAGGTATGTATGAAGGCTACTCTCAACATAGTCTCTGGGG...
pathogenic
92,150
Chromosome 5, position 37213580, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Joubert_syndrome_1', 'Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
CTCAAGGCTATGCGGGGGCACTTCCTCCAGACGCCTCTCCTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTTGAAAGTGAAATATATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTATCCTGACAGAATGCCCCCGCCATCACCCGCTGAGTCTAGGCACAACCTCTCCATCCCTCCCTTCTCCAGCCCTCCGGAGCAGAAAGCGGGTCTTTACTGGAGACAAAATGAACTTCAAGACAAAAGTGAATTTTCAGATGCGGACAAGCTAGCTTTTAAGGATAACGAGGAATTTGAATCATCTTTTG...
CTCAAGGCTATGCGGGGGCACTTCCTCCAGACGCCTCTCCTCCACACCCCTTCCAAAAGCAAAAAGAAGCCTTGAAAGTGAAATATATCTGGAAGGTCTGGGCAGATCACACATTGCTTCCCCCAGTCCTTATCCTGACAGAATGCCCCCGCCATCACCCGCTGAGTCTAGGCACAACCTCTCCATCCCTCCCTTCTCCAGCCCTCCGGAGCAGAAAGCGGGTCTTTACTGGAGACAAAATGAACTTCAAGACAAAAGTGAATTTTCAGATGCGGACAAGCTAGCTTTTAAGGATAACGAGGAATTTGAATCATCTTTTG...
pathogenic
92,154
Mutation found at chromosome 5 position 37221307, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
benign
92,155
For chromosome 5, position 37221307, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
benign
92,156
Determine whether the variant at chromosome 5, position 37221307, in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
GTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCAAGGTGTGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTCAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAAAGGTTGCAGTAAGCCAAGATCACGCCACTACACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAAAAAGAAAAAAAAAATTAGCCAGGCGTGAGGCACATGCCTGTGGTT...
benign
92,157
The mutation in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) at chromosome 5, position 37224537—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Joubert_syndrome_17', 'Joubert_syndrome_and_related_disorders', 'Orofaciodigital_syndrome_type_6']
CCCAAACTGCAACTTCTGCCCTCCTTTCACAAAGGAAAGCCACTCTTTCTCTGTTGAAGCCACTGCTACTTTCAATCTCCATTACTAGAAGCCATTCCTAATGGATGTAGTTGTAAATGAAATTAAACAAAATGTCCATAATGGAACTCATTACAAAAACTTTTCTATACCCAGAACTTCAGATCTCAGTGAATGCTGCTCTTTTCATCCAGATGGACAATCCCCAAGTCAGAGAACTACACTAGCCTTCTTTCTCCAAATCTACTCAATCACAAGTAGACTGATCAAGCCTATTAAATAACTGTCAAATGTAACCTCTG...
CCCAAACTGCAACTTCTGCCCTCCTTTCACAAAGGAAAGCCACTCTTTCTCTGTTGAAGCCACTGCTACTTTCAATCTCCATTACTAGAAGCCATTCCTAATGGATGTAGTTGTAAATGAAATTAAACAAAATGTCCATAATGGAACTCATTACAAAAACTTTTCTATACCCAGAACTTCAGATCTCAGTGAATGCTGCTCTTTTCATCCAGATGGACAATCCCCAAGTCAGAGAACTACACTAGCCTTCTTTCTCCAAATCTACTCAATCACAAGTAGACTGATCAAGCCTATTAAATAACTGTCAAATGTAACCTCTG...
pathogenic
92,165
Gene mutation in CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) at chromosome 5, position 37224608—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Joubert_syndrome_and_related_disorders']
TCAATCTCCATTACTAGAAGCCATTCCTAATGGATGTAGTTGTAAATGAAATTAAACAAAATGTCCATAATGGAACTCATTACAAAAACTTTTCTATACCCAGAACTTCAGATCTCAGTGAATGCTGCTCTTTTCATCCAGATGGACAATCCCCAAGTCAGAGAACTACACTAGCCTTCTTTCTCCAAATCTACTCAATCACAAGTAGACTGATCAAGCCTATTAAATAACTGTCAAATGTAACCTCTGTTCTCCATTACCCTTGACATTGCTTTGGTTTCAAGGCTTCTCGTCTGACTGATTTTCTTGCCTCCAAGTAA...
TCAATCTCCATTACTAGAAGCCATTCCTAATGGATGTAGTTGTAAATGAAATTAAACAAAATGTCCATAATGGAACTCATTACAAAAACTTTTCTATACCCAGAACTTCAGATCTCAGTGAATGCTGCTCTTTTCATCCAGATGGACAATCCCCAAGTCAGAGAACTACACTAGCCTTCTTTCTCCAAATCTACTCAATCACAAGTAGACTGATCAAGCCTATTAAATAACTGTCAAATGTAACCTCTGTTCTCCATTACCCTTGACATTGCTTTGGTTTCAAGGCTTCTCGTCTGACTGATTTTCTTGCCTCCAAGTAA...
pathogenic
92,167
The genetic variant at chromosome 5, position 37226717, affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GGAACTCTTCGATTTAATTGTGCTTGATACCATAAAGTTTTTTTGTACAGTATTCTCCAGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGT...
GGAACTCTTCGATTTAATTGTGCTTGATACCATAAAGTTTTTTTGTACAGTATTCTCCAGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGT...
pathogenic
92,177
Located at chromosome 5 position 37226775, the variant affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Joubert_syndrome_17', 'Joubert_syndrome_and_related_disorders', 'Orofaciodigital_syndrome_type_6']
AGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGTTGCCCAGACTGATCTCAAACTCCTGGGCCCAAGCGATCACCCTACCTCAGCCTCCCGA...
AGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGTTGCCCAGACTGATCTCAAACTCCTGGGCCCAAGCGATCACCCTACCTCAGCCTCCCGA...
pathogenic
92,178
Considering the genetic mutation at chromosome 5, position 37226775, impacting CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['CPLANE1-related_disorder', 'Global_developmental_delay', 'Inborn_genetic_diseases', 'Jaundice', 'Joubert_syndrome_17', 'Nephronophthisis', 'Orofaciodigital_syndrome_type_6']
AGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGTTGCCCAGACTGATCTCAAACTCCTGGGCCCAAGCGATCACCCTACCTCAGCCTCCCGA...
AGAGAATAAGCAATCTGCACATAAAATCAGGTAATTATCAAAAGCAAATTTCAGGCTAATGATGAGTTTAGCCTCCTTTTTAGCCTATTTTTTTTTTTGCCTGTATTCTTCATCGGTATAACATACATACAAACTGATCACATTTAAATATAGTGCAAAATAAAATGATTAAAAAATGCCTTATATAAAATCTTCATAAATATTTTAAGCACCTGTAATCTTTTTTTTTTTTTTTTTTTTAAGACACAAGGTCTCACTACGTTGCCCAGACTGATCTCAAACTCCTGGGCCCAAGCGATCACCCTACCTCAGCCTCCCGA...
pathogenic
92,179
Does the variant on chromosome 5 at location 37227088 affecting gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
CTCCCGAACAGGTGAGATTACAGGTATGTGCCACTGCACTCCAGCCTGGGAGACAGGGTCTTGCTCTGTTGCCAGGCTGAATTGCAGTGGCTCCATCACAGCTTACTGTAGCCTCAACCTCCTGGGTTCAAGCAATCCTCCCATCTCAGCCTCCCGGGCTCAAGCAATCCTCCCATCTCAGCCTCCCAGGTAGCTGGGACCACAGGTGCACCACACTGTTTTTTTTTTCTTTTCAGGCAAGGTCTCCTCCTGTCGCCCATGCTGGAATGCAGTGGCGTGATATCTGCTCAACCTCTGCCTCCTGGACTCAAGCAATCCTC...
CTCCCGAACAGGTGAGATTACAGGTATGTGCCACTGCACTCCAGCCTGGGAGACAGGGTCTTGCTCTGTTGCCAGGCTGAATTGCAGTGGCTCCATCACAGCTTACTGTAGCCTCAACCTCCTGGGTTCAAGCAATCCTCCCATCTCAGCCTCCCGGGCTCAAGCAATCCTCCCATCTCAGCCTCCCAGGTAGCTGGGACCACAGGTGCACCACACTGTTTTTTTTTTCTTTTCAGGCAAGGTCTCCTCCTGTCGCCCATGCTGGAATGCAGTGGCGTGATATCTGCTCAACCTCTGCCTCCTGGACTCAAGCAATCCTC...
benign
92,185
Gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1) variant at chromosome 5, position 37227369—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Joubert_syndrome_1', 'Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
ATCTGCTCAACCTCTGCCTCCTGGACTCAAGCAATCCTCCCACCTCAGCCTCCTGGGTCGCTGGGATTACAGGCACATGCCAATAGGCCTGGCTAATTTTTTAGTTGCGGAGTTTCATCGTGTTGCCCAAGCTAGTCCTGGGGTCAAGTGATCCACCCACCTCAGCCTCCCAAAGTGCTCGATCACAGGCGTGAGCCACTGCGCCCAGCCTAATTTTTTAAAGAGGTCATTTTTTTAAGAGGTCATTTTGGCCGGGCGTGGTGGCTCACGCCTATAATCCCAACACTTTGGGAGGCTGAAGCGGGCGGATCACCTGAGGT...
ATCTGCTCAACCTCTGCCTCCTGGACTCAAGCAATCCTCCCACCTCAGCCTCCTGGGTCGCTGGGATTACAGGCACATGCCAATAGGCCTGGCTAATTTTTTAGTTGCGGAGTTTCATCGTGTTGCCCAAGCTAGTCCTGGGGTCAAGTGATCCACCCACCTCAGCCTCCCAAAGTGCTCGATCACAGGCGTGAGCCACTGCGCCCAGCCTAATTTTTTAAAGAGGTCATTTTTTTAAGAGGTCATTTTGGCCGGGCGTGGTGGCTCACGCCTATAATCCCAACACTTTGGGAGGCTGAAGCGGGCGGATCACCTGAGGT...
pathogenic
92,188
For chromosome 5, position 37238834, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
CATACAATCAGCCAATAAACATATGAAAAAATGCTCAACATCACTAATCATCAGAGAAATGCAAATTAAAACCACAACGAGATAACATACCAGTCAGAATGGCTATTACTAAAAAGTCAAAAAACAACATGTTGGCAAGTATGCAGAGGAAAGGGAACATGGGAACATGTTTCTCATGGGAACGTGAGAAAAGGGAACAAACATGATTGGTGGGAACGCAAATTAGTACAATCATTATGGTATAGAGATTTCTCAAAGAACCAAAATAGGAACTACCATTCAATCTAGTAATCCCACTATTGGGTATATACCCAAAGGGA...
CATACAATCAGCCAATAAACATATGAAAAAATGCTCAACATCACTAATCATCAGAGAAATGCAAATTAAAACCACAACGAGATAACATACCAGTCAGAATGGCTATTACTAAAAAGTCAAAAAACAACATGTTGGCAAGTATGCAGAGGAAAGGGAACATGGGAACATGTTTCTCATGGGAACGTGAGAAAAGGGAACAAACATGATTGGTGGGAACGCAAATTAGTACAATCATTATGGTATAGAGATTTCTCAAAGAACCAAAATAGGAACTACCATTCAATCTAGTAATCCCACTATTGGGTATATACCCAAAGGGA...
benign
92,200
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 5, position 37238886, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1). What disease(s) is it linked to if pathogenic?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
AGAGAAATGCAAATTAAAACCACAACGAGATAACATACCAGTCAGAATGGCTATTACTAAAAAGTCAAAAAACAACATGTTGGCAAGTATGCAGAGGAAAGGGAACATGGGAACATGTTTCTCATGGGAACGTGAGAAAAGGGAACAAACATGATTGGTGGGAACGCAAATTAGTACAATCATTATGGTATAGAGATTTCTCAAAGAACCAAAATAGGAACTACCATTCAATCTAGTAATCCCACTATTGGGTATATACCCAAAGGGAAAGAAATCATTATATCAAAAAGATACTTGCACTCACACGTTTATCACATCAC...
AGAGAAATGCAAATTAAAACCACAACGAGATAACATACCAGTCAGAATGGCTATTACTAAAAAGTCAAAAAACAACATGTTGGCAAGTATGCAGAGGAAAGGGAACATGGGAACATGTTTCTCATGGGAACGTGAGAAAAGGGAACAAACATGATTGGTGGGAACGCAAATTAGTACAATCATTATGGTATAGAGATTTCTCAAAGAACCAAAATAGGAACTACCATTCAATCTAGTAATCCCACTATTGGGTATATACCCAAAGGGAAAGAAATCATTATATCAAAAAGATACTTGCACTCACACGTTTATCACATCAC...
pathogenic
92,202
Mutation found at chromosome 5 position 37244434, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
AGGCTTTTTAGAATAAAACTATTTTTAAATAAAAGAACACTTAAGCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGAT...
AGGCTTTTTAGAATAAAACTATTTTTAAATAAAAGAACACTTAAGCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGAT...
pathogenic
92,212
Regarding the variant found on chromosome 5 at position 37244451 in gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
ACTATTTTTAAATAAAAGAACACTTAAGCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGATCAAAAGATAATAATGTT...
ACTATTTTTAAATAAAAGAACACTTAAGCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGATCAAAAGATAATAATGTT...
pathogenic
92,213
Clinical classification of chromosome 5, position 37244478, gene CPLANE1 (ciliogenesis and planar polarity effector complex subunit 1): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Joubert_syndrome_17', 'Orofaciodigital_syndrome_type_6']
GCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGATCAAAAGATAATAATGTTTAAAAAGGGATAGAAAATATGGGGCCG...
GCATTTAAAAGGTACAATAGGAAATCAAAAGTTATGTCCCTTTTAAATTTCAACTGAATTCTTTTCCAGAATAGTTACTTTTATAGTCTTAGACAAGTAAAACCATAGCTTGTCTTATCTTTTACAAATTCTCACTTCAAAGAAGGGAAACAAGACAAAACAAGATAAACTTTCTGGATTAAACATTTAGAAATAAGAGGGGAAGAAATGATTTGTAAAGCCTCAGAACTTGAAACTCACAATAACATTTACAAATTTTATTACATGTATATGGATCAAAAGATAATAATGTTTAAAAAGGGATAGAAAATATGGGGCCG...
pathogenic
92,214
Is the chromosome 5, position 37815487 variant in GDNF (glial cell derived neurotrophic factor) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
GTAACAAGCTGTAATACAGGGCCTAGTGTGTCATACATGTGTTGGCTGCCCGATAAATTCACAATCTAGGGCATGGAGGAGGTGGCTGTTCCCGCCCCTATGCTTCCTCCTGCTCCAACCTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTACCGCACTGTCACTTAGGCTGGAGTGCAGTGGCATGATCACAGCTCACTGCAGCCTCGACCTTCTGGACTCAAGTGATCCTCCTTCAGCCTCTTGAGTAGCTGGGACCACAGGTGTGCACCATCATGCCTGCCTAATTTTTAAAGTTTCTGTAGAGACAGGGTCT...
GTAACAAGCTGTAATACAGGGCCTAGTGTGTCATACATGTGTTGGCTGCCCGATAAATTCACAATCTAGGGCATGGAGGAGGTGGCTGTTCCCGCCCCTATGCTTCCTCCTGCTCCAACCTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTACCGCACTGTCACTTAGGCTGGAGTGCAGTGGCATGATCACAGCTCACTGCAGCCTCGACCTTCTGGACTCAAGTGATCCTCCTTCAGCCTCTTGAGTAGCTGGGACCACAGGTGTGCACCATCATGCCTGCCTAATTTTTAAAGTTTCTGTAGAGACAGGGTCT...
benign
92,269
Variant on chromosome 5, at position 38499562, affecting LIFR (LIF receptor subunit alpha): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Stüve-Wiedemann_syndrome_1']
AAACAAAACATTTTAAAAAATAGCATCATGGGTTTTTTTCTAAACATTTGTTTTCTCATTTTAAAGTATTACATGCCCACTACAGAAAATTTGGAAAATATATAGAAGTTGAAACAAGTAAAAATCTCCCATATTCCCACCTCTTAAGTATTCTTTCATTTTGATATTTCTTTCAAGTTGTTTTTCTAGGTATAGATTTTTTTACTAACATTGTTTTAATCATATTACACCATTTTACTTTTTACTTTTCCATAATATATGCTAATATACGCTTGTCCATAATACAGTTATATACATTTTCATGGTTTTATGTCTTATGT...
AAACAAAACATTTTAAAAAATAGCATCATGGGTTTTTTTCTAAACATTTGTTTTCTCATTTTAAAGTATTACATGCCCACTACAGAAAATTTGGAAAATATATAGAAGTTGAAACAAGTAAAAATCTCCCATATTCCCACCTCTTAAGTATTCTTTCATTTTGATATTTCTTTCAAGTTGTTTTTCTAGGTATAGATTTTTTTACTAACATTGTTTTAATCATATTACACCATTTTACTTTTTACTTTTCCATAATATATGCTAATATACGCTTGTCCATAATACAGTTATATACATTTTCATGGTTTTATGTCTTATGT...
pathogenic
92,322
Considering the genetic mutation at chromosome 5, position 38502658, impacting LIFR (LIF receptor subunit alpha): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Stuve-Wiedemann_syndrome']
CAGGTTTTCAGATTACGTATGTTCAATCTGTAATGCATACTCAGTAAATATTTGTTGAGTAAATTGATGCCTTCATCTTAATGAGGTGCAAATAAGATGTTTCCTCTTGGAGACAACAGCTCATTAACTGAAGGCAAAAACTACAGTGGCTAGTCTCCAAAATGACCAATAATCCCCATGTGCGTGGTGCCCTCCCACATTGCATCAGGGTTGGCCTGTGTGACCAACAGTGTGCAGTAGACATAATGGTATGTTACTTCCGATTTTAGAGCATAAAAGATACTGTTCAGTCACCGGCTCTGGGAGGAACTGGCTGCCAT...
CAGGTTTTCAGATTACGTATGTTCAATCTGTAATGCATACTCAGTAAATATTTGTTGAGTAAATTGATGCCTTCATCTTAATGAGGTGCAAATAAGATGTTTCCTCTTGGAGACAACAGCTCATTAACTGAAGGCAAAAACTACAGTGGCTAGTCTCCAAAATGACCAATAATCCCCATGTGCGTGGTGCCCTCCCACATTGCATCAGGGTTGGCCTGTGTGACCAACAGTGTGCAGTAGACATAATGGTATGTTACTTCCGATTTTAGAGCATAAAAGATACTGTTCAGTCACCGGCTCTGGGAGGAACTGGCTGCCAT...
pathogenic
92,324
Variant on chromosome 5, at position 38505961, affecting LIFR (LIF receptor subunit alpha): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Stüve-Wiedemann_syndrome_1']
AATTCTTTTTGAGAACTATTTTATCCAAAATAATCACAAAGGAAGTCTTTAAGAGAATCTTACCTGCTCTTGTACTGAATTAGATTTCTTAATTTCAATTTCACATAAAAAATTAATCTTTGCAAAGTTGCCTGGTAAATGCCAAGAAAGTTTAACAGCTGTTGAATTAATATCCTTCACTTTGAATGAAGTAGGAGTATGGGGATAAACTGCAAATATAATTTTTAAAGATTAAACACTTATTTAAAGGGAAAAACTATCTTCTAATATGACAAATGAGAAGAAAACATAAAAAACAACGAGGCATCATTAGTGCTGAC...
AATTCTTTTTGAGAACTATTTTATCCAAAATAATCACAAAGGAAGTCTTTAAGAGAATCTTACCTGCTCTTGTACTGAATTAGATTTCTTAATTTCAATTTCACATAAAAAATTAATCTTTGCAAAGTTGCCTGGTAAATGCCAAGAAAGTTTAACAGCTGTTGAATTAATATCCTTCACTTTGAATGAAGTAGGAGTATGGGGATAAACTGCAAATATAATTTTTAAAGATTAAACACTTATTTAAAGGGAAAAACTATCTTCTAATATGACAAATGAGAAGAAAACATAAAAAACAACGAGGCATCATTAGTGCTGAC...
pathogenic
92,329
Regarding the variant at chromosome 5 and position 38510539, affecting gene LIFR (LIF receptor subunit alpha): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Stuve-Wiedemann_syndrome']
AAAACGCCAGCAGGTTTTGATTGGGTAGGTGTGTGTGCACGCAGACGTGTGTGTAGGGAAAAACTAACAAGCCGATTATAAATTTCTTTTTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCACTCTCCTGCCTCAGCTTCCCGAGTAGCTGAGACCACAGGCGCCTGCCACCATGCCCAGCTAATTTTTTTGTATTTTCTTTTTTTAATAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCT...
AAAACGCCAGCAGGTTTTGATTGGGTAGGTGTGTGTGCACGCAGACGTGTGTGTAGGGAAAAACTAACAAGCCGATTATAAATTTCTTTTTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAAGCTCCGCCTCCTGGGTTCATGCCACTCTCCTGCCTCAGCTTCCCGAGTAGCTGAGACCACAGGCGCCTGCCACCATGCCCAGCTAATTTTTTTGTATTTTCTTTTTTTAATAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCT...
pathogenic
92,337
Determine if the mutation at chromosome 5, position 38510698 in gene LIFR (LIF receptor subunit alpha) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Stuve-Wiedemann_syndrome', 'Stüve-Wiedemann_syndrome_1']
CACTGCAAGCTCCGCCTCCTGGGTTCATGCCACTCTCCTGCCTCAGCTTCCCGAGTAGCTGAGACCACAGGCGCCTGCCACCATGCCCAGCTAATTTTTTTGTATTTTCTTTTTTTAATAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGCGCTGGGATTACAGGCGTAAGCCACCACACCCGGCCTAAATTTCTTTTCAGTCTTTTCCGTAAATGGTGGCTTAACAGGATATCCATAAAGAAAGGAAATAAATGAATCCTGATACCTAACT...
CACTGCAAGCTCCGCCTCCTGGGTTCATGCCACTCTCCTGCCTCAGCTTCCCGAGTAGCTGAGACCACAGGCGCCTGCCACCATGCCCAGCTAATTTTTTTGTATTTTCTTTTTTTAATAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGCGCTGGGATTACAGGCGTAAGCCACCACACCCGGCCTAAATTTCTTTTCAGTCTTTTCCGTAAATGGTGGCTTAACAGGATATCCATAAAGAAAGGAAATAAATGAATCCTGATACCTAACT...
pathogenic
92,339
A mutation at chromosome position 38511872 on chromosome 5 in gene LIFR (LIF receptor subunit alpha): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Stuve-Wiedemann_syndrome', 'Stüve-Wiedemann_syndrome_1']
AAGCCACATGGGCAGGGCAGCCCACAACAAACTACTTTTGGAAATACCATGGAATTTTAGACTGTGGGGTGATCATGTTAATAGACACCTTGAATGACAGAGCATACAACATATATAGAACGCAGTGGGAGAGTATGTTTCCCCTCACCCATGTCCTCCTGCCAGCCTGTTCTCCTCAAATATAATAGTTAAAAGATGGAGAAGATATGTTATGCTACTGAAAGATTTTGTGTAAAATTGCTATAATTTCTTTAATTTAGATACTTTAAAAAAGGTATACTTTAACTGGAAAATGAATTCACATAATTTCTAAACAATGC...
AAGCCACATGGGCAGGGCAGCCCACAACAAACTACTTTTGGAAATACCATGGAATTTTAGACTGTGGGGTGATCATGTTAATAGACACCTTGAATGACAGAGCATACAACATATATAGAACGCAGTGGGAGAGTATGTTTCCCCTCACCCATGTCCTCCTGCCAGCCTGTTCTCCTCAAATATAATAGTTAAAAGATGGAGAAGATATGTTATGCTACTGAAAGATTTTGTGTAAAATTGCTATAATTTCTTTAATTTAGATACTTTAAAAAAGGTATACTTTAACTGGAAAATGAATTCACATAATTTCTAAACAATGC...
pathogenic
92,340
Located at chromosome 5 position 38523500, the variant affecting gene LIFR (LIF receptor subunit alpha)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Stüve-Wiedemann_syndrome_1']
ACTATTGTTGAATAAGAGTGGCGTAAGTGGTCCAGTCTTTGGGTCCCGGCAGTGGAAGTGGTAAGCCGAGTATGCCTGTCTTTGGACCCCAGGATGGCATTCACTGGCCCCATTGTTAGTGGGTCCAAGGGGGCCAATTCTTGAGCGTCCAGGTGGCTTGCTTGGATGCTGGTATTGAGAGTGGTGGGCTGGGTACGTTCTCAGGCCCCTGGCCAGCAGGTGTGGTGTGGGTGATGGCAGTAGCAGTGGTAGGATAACCCTCTGGGTCTTGAGCAGTGCACTCTGGTGCTGACAGTAGATACAATGTGCTGAGTGGGCCA...
ACTATTGTTGAATAAGAGTGGCGTAAGTGGTCCAGTCTTTGGGTCCCGGCAGTGGAAGTGGTAAGCCGAGTATGCCTGTCTTTGGACCCCAGGATGGCATTCACTGGCCCCATTGTTAGTGGGTCCAAGGGGGCCAATTCTTGAGCGTCCAGGTGGCTTGCTTGGATGCTGGTATTGAGAGTGGTGGGCTGGGTACGTTCTCAGGCCCCTGGCCAGCAGGTGTGGTGTGGGTGATGGCAGTAGCAGTGGTAGGATAACCCTCTGGGTCTTGAGCAGTGCACTCTGGTGCTGACAGTAGATACAATGTGCTGAGTGGGCCA...
pathogenic
92,344
The chromosome 5, position 38527134 genetic variant in gene LIFR (LIF receptor subunit alpha): benign or pathogenic? If pathogenic, indicate disease(s).
benign
GAATCCAGGACACTAAAAAAGGTAGCAGGAAGAGTAATGTATCCTTGAAAATCATTAACTCTCCCTAAGGGCGGATAAATCATGGAAAATTTTGGACCAATGGAAAACAAAGAAGGTATGAGCATGTTCCATTCTATGAAATGTAGACTTTCTGGTTTGAGAATCAGAGAGACTTGGACTTTCTTCCATGTTTCCTCCTCAAATAACAGTAAAGTAAAGGTGAGTTAGAAGAAATCCATAGACTCACCCTTTCTTGCCTCATTTCTATCCTAGAAGCTCAAGGACCAATTACATATAGTCATGGTAAGCCCAAAACTGCA...
GAATCCAGGACACTAAAAAAGGTAGCAGGAAGAGTAATGTATCCTTGAAAATCATTAACTCTCCCTAAGGGCGGATAAATCATGGAAAATTTTGGACCAATGGAAAACAAAGAAGGTATGAGCATGTTCCATTCTATGAAATGTAGACTTTCTGGTTTGAGAATCAGAGAGACTTGGACTTTCTTCCATGTTTCCTCCTCAAATAACAGTAAAGTAAAGGTGAGTTAGAAGAAATCCATAGACTCACCCTTTCTTGCCTCATTTCTATCCTAGAAGCTCAAGGACCAATTACATATAGTCATGGTAAGCCCAAAACTGCA...
benign
92,348
Clinical classification of chromosome 5, position 38527152, gene LIFR (LIF receptor subunit alpha): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Stüve-Wiedemann_syndrome_1']
AAGGTAGCAGGAAGAGTAATGTATCCTTGAAAATCATTAACTCTCCCTAAGGGCGGATAAATCATGGAAAATTTTGGACCAATGGAAAACAAAGAAGGTATGAGCATGTTCCATTCTATGAAATGTAGACTTTCTGGTTTGAGAATCAGAGAGACTTGGACTTTCTTCCATGTTTCCTCCTCAAATAACAGTAAAGTAAAGGTGAGTTAGAAGAAATCCATAGACTCACCCTTTCTTGCCTCATTTCTATCCTAGAAGCTCAAGGACCAATTACATATAGTCATGGTAAGCCCAAAACTGCAGGACAGTGCAGGGCTAGG...
AAGGTAGCAGGAAGAGTAATGTATCCTTGAAAATCATTAACTCTCCCTAAGGGCGGATAAATCATGGAAAATTTTGGACCAATGGAAAACAAAGAAGGTATGAGCATGTTCCATTCTATGAAATGTAGACTTTCTGGTTTGAGAATCAGAGAGACTTGGACTTTCTTCCATGTTTCCTCCTCAAATAACAGTAAAGTAAAGGTGAGTTAGAAGAAATCCATAGACTCACCCTTTCTTGCCTCATTTCTATCCTAGAAGCTCAAGGACCAATTACATATAGTCATGGTAAGCCCAAAACTGCAGGACAGTGCAGGGCTAGG...
pathogenic
92,349
Evaluate the clinical significance of the mutation at chromosome 5, position 38528728 in gene LIFR (LIF receptor subunit alpha): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Stüve-Wiedemann_syndrome_1']
CTTATCCCAATACTGTTATTCTAATCATGATCAGGACCATTATTATTTATAATGCTACCAATACATTACATGATATGTAAAACACAATGAACTATTAATCGACTGAGTCTCCTACAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTT...
CTTATCCCAATACTGTTATTCTAATCATGATCAGGACCATTATTATTTATAATGCTACCAATACATTACATGATATGTAAAACACAATGAACTATTAATCGACTGAGTCTCCTACAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTT...
pathogenic
92,352
Regarding the variant at chromosome 5 and position 38528772, affecting gene LIFR (LIF receptor subunit alpha): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Stüve-Wiedemann_syndrome_1']
ATTTATAATGCTACCAATACATTACATGATATGTAAAACACAATGAACTATTAATCGACTGAGTCTCCTACAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGT...
ATTTATAATGCTACCAATACATTACATGATATGTAAAACACAATGAACTATTAATCGACTGAGTCTCCTACAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGT...
pathogenic
92,353
Variant in LIFR (LIF receptor subunit alpha), chromosome 5, position 38528842—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
CAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACA...
CAGTCTGTCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACA...
benign
92,355
Variant at chromosome 5, position 38528849, gene LIFR (LIF receptor subunit alpha): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
TCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACACTTGACT...
TCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACACTTGACT...
benign
92,356
Variant at chromosome position 38528849, chromosome 5, gene LIFR (LIF receptor subunit alpha): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
benign
TCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACACTTGACT...
TCTTGATTTGCCTTTCTGATTCTAATACTGTCATTTTTCAGTAGCTTCCCAGATAAGACTACACCCTAGAGCAAGGGGCATCTGAGAAATTCTGGAAGGTACGCAGGAGTCAAGGGGGCTAAAGAAAGAGTATGGAACTGAGGGAAGGAGCCTGAATTCTGGGCTATTTTGACTGGCCAGAAGAAAAGTTTGCTTCCTTCTGATCTTGGCTACCATCTACAATTCATAGGGAGGTTGCTGAGTGAATTAAAAGTAATAGCATAACACATGAAATTCAAAAAACTAGAAAGCACCACAATACTAACAAGTGACACTTGACT...
benign
92,357
Classify the chromosome 5 variant at position 38530624 affecting gene LIFR (LIF receptor subunit alpha) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Stüve-Wiedemann_syndrome_1']
AAAAATGAGGCAGAGGTCACGGCAGACTCTGCTGGACACAGAACACAAGCAGGAAATAACCCTTTAGTTTCACAAGCAATAAGGTAAGAACTGAGGGTCGTTTCTGCAATTCAACCTAGCTCATTGTGAATTAAAGTAAATTAAAATTACCTGTTTTCAATGCAAACTTCATAATCAGTACCACGGCCTGTTCCAGAGGGTGCTTTCCAAGAACAGTTCCACACTTGCAAATTGTTAGTTACACACTTCAAATCATGAGGAGCCCCTGGAGGAGACACACACACACACACACACACACACACAGACACACATAAACACAG...
AAAAATGAGGCAGAGGTCACGGCAGACTCTGCTGGACACAGAACACAAGCAGGAAATAACCCTTTAGTTTCACAAGCAATAAGGTAAGAACTGAGGGTCGTTTCTGCAATTCAACCTAGCTCATTGTGAATTAAAGTAAATTAAAATTACCTGTTTTCAATGCAAACTTCATAATCAGTACCACGGCCTGTTCCAGAGGGTGCTTTCCAAGAACAGTTCCACACTTGCAAATTGTTAGTTACACACTTCAAATCATGAGGAGCCCCTGGAGGAGACACACACACACACACACACACACACACAGACACACATAAACACAG...
pathogenic
92,361