sot_question stringlengths 42 9.8k | ds_name stringclasses 8
values | pred_label int64 0 2 | logits listlengths 3 3 |
|---|---|---|---|
['Necrostatin-1 (Nec-1) inhibits necroptosis, a nonapoptotic cell death pathway. Acute kidney injury (AKI) is a clinical problem of high incidence and mortality. It involves several mechanisms of cell death. We aim to evaluate the effect of Nec-1 in the toxic kidney injury model by cisplatin.', 'We analyzed the effect ... | qiaojin/PubMedQA | 2 | [
-2.3400464057922363,
-1.2727441787719727,
2.6596291065216064
] |
['The aim of this study was to assess the applicability of knowledge discovery in database methodology, based upon data mining techniques, to the investigation of lung cancer surgery.', 'According to CRISP 1.0 methodology, a data mining (DM) project was developed on a data warehouse containing records for 501 patients ... | qiaojin/PubMedQA | 2 | [
-2.018669843673706,
-1.063759207725525,
2.3504862785339355
] |
['We aimed to examine the relationship between iron status and hypertension as few studies have addressed this.', 'We analyzed the association between ferritin/total iron-binding capacity (TIBC) and the subsequent development of hypertension. A total of 8,580 men who visited the Health Promotion Center for a medical ch... | qiaojin/PubMedQA | 2 | [
-1.4745242595672607,
-1.2494003772735596,
1.762570858001709
] |
['In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and gene-based approaches have proven efficient in restraining inflammation and correcting the obese phenotypes. However, the role of nutrients in the modulation of hypo... | qiaojin/PubMedQA | 2 | [
-2.648651361465454,
-1.0055326223373413,
2.6638600826263428
] |
['Chronic infections could be contributing to the socioeconomic gradient in chronic diseases. Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes.', 'We examined the association b... | qiaojin/PubMedQA | 2 | [
-2.2955663204193115,
-0.9140895009040833,
2.294123411178589
] |
['To describe the trend of blood glucose immediately after successful resuscitation from out-of-hospital ventricular fibrillation.', 'Data from cardiac arrest registry supplemented with blood glucose data were analyzed in this population-based observational study. Between 2005 and 2009, a total of 170 adult patients su... | qiaojin/PubMedQA | 2 | [
-0.9843780398368835,
-1.1994602680206299,
1.3098405599594116
] |
['Cross-sectional cohort study.', 'To investigate the differences in the level of activation of neck-shoulder muscles between elite swimmers with and without shoulder pain during a functional upper-limb task.', 'Previous studies have reported altered motor control of the neck-shoulder muscles in patients with chronic n... | qiaojin/PubMedQA | 2 | [
-1.715614676475525,
-0.8034696578979492,
1.6149721145629883
] |
['Cardiovascular complications are major causes of morbidity and mortality following non-cardiac thoracic operations. Recent studies have demonstrated that elevation of N-Terminal Pro-B-type natriuretic peptide (NT-proBNP) levels can predict cardiac complications following non-cardiac major surgery as well as cardiac s... | qiaojin/PubMedQA | 2 | [
-1.4676719903945923,
-1.5796879529953003,
2.079376697540283
] |
['We investigated the stability, pharmacokinetic, and pharmacodynamic profile of the 2(nd) generation anti-von Willeband factor aptamer ARC15105.', 'Platelet plug formation was measured by collagen/adenosine diphosphate-induced closure time with the platelet function analyzer-100 and platelet aggregation by multiple el... | qiaojin/PubMedQA | 2 | [
-2.0186121463775635,
-1.5701079368591309,
2.584989070892334
] |
['Here, we assessed the presence of intrahepatic follicular helper T-cells (T(FH)) in a cohort of consecutive genotype 1 (G1) chronic hepatitis C (CHC) patients comprising non-responders (NRs), relapsers (RRs) or those with sustained virological response (SVR) to pegylated interferon and ribavirin, and tested their rel... | qiaojin/PubMedQA | 2 | [
-0.9323387742042542,
-1.8133573532104492,
1.7272744178771973
] |
['We hypothesized that arachidonic acid produced by anandamide breakdown contributes to the vascular effects of anandamide.', 'Isolated, pressurized rat skeletal muscle arteries, which possess spontaneous myogenic tone, were treated with anandamide, arachidonic acid, capsaicin (vanilloid receptor agonist), WIN 55-212-2... | qiaojin/PubMedQA | 2 | [
-2.3884758949279785,
-1.3484753370285034,
2.7602171897888184
] |
['The proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes independently of its enzymatic activity the degradation of the low-density lipoprotein (LDL) receptor. PCSK9 gain of function in humans leads to autosomal dominant hypercholesterolemia, whereas the absence of functional PCSK9 results in ≈7-fold lower ... | qiaojin/PubMedQA | 2 | [
-1.9915388822555542,
-1.4736417531967163,
2.42905855178833
] |
['The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction are clinically important and generally treated with electronic pacemakers. Although an excellent solution, electronic pacemakers incorporate limitations that ... | qiaojin/PubMedQA | 2 | [
-2.628465414047241,
-1.00077486038208,
2.675532341003418
] |
['It has been much debated whether atopic dermatitis (AD) is associated with contact sensitization as past findings have been conflicting. A positive association might change our clinical practice.', 'To investigate the association between AD and contact sensitization taking the likely route of allergen exposure into a... | qiaojin/PubMedQA | 2 | [
-2.6739871501922607,
-0.8289906978607178,
2.630661964416504
] |
['To assess the potential of metastasin S100A4 as a biological marker in patients with RA.', 'A total of 87 unselected patients with established RA (disease duration 2-44 years) and treated with MTX and infliximab at a single rheumatology centre were included in a cross-sectional study. Radiographs of hands and feet we... | qiaojin/PubMedQA | 2 | [
-1.8307106494903564,
-1.626067042350769,
2.493063449859619
] |
['It remains unclear if patients with clinical stage T2 N0 (cT2 N0) esophageal cancer should be offered induction therapy vs surgical intervention alone.', 'This was a retrospective cohort study of cT2 N0 patients undergoing induction therapy, followed by surgical resection, or resection alone, at the Johns Hopkins Hos... | qiaojin/PubMedQA | 2 | [
-1.7564624547958374,
-1.4004236459732056,
2.196061849594116
] |
['Fenofibrate, an agonist of peroxisome proliferator-activated receptor-α (PPAR-α), has a vascular protective effect.', 'We investigated the effect of the PPAR-α agonist on coronary artery endothelial function in patients with hypertriglyceridemia.', 'Fifty-eight patients with hypertriglyceridemia were divided into two... | qiaojin/PubMedQA | 2 | [
-1.4842523336410522,
-1.7284222841262817,
2.165390968322754
] |
['To describe the clinical outcomes of patients with cytomegalovirus (CMV) retinitis and AIDS treated with ganciclovir implant.', 'Retrospective cohort study.', 'The charts of 115 patients (166 affected eyes) with CMV retinitis treated with ganciclovir implant in the Division of Ocular Immunology, Wilmer Eye Institute ... | qiaojin/PubMedQA | 2 | [
-1.863955020904541,
-1.5252466201782227,
2.369971752166748
] |
['The dsRNA-activated protein kinase (PKR) phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), a global regulator of protein synthesis in mammals. In addition, PKR activates several signal transduction pathways including STAT3 and AKT. PKR is activated by a number of inflammatory stimuli... | qiaojin/PubMedQA | 2 | [
-2.4523894786834717,
-1.2327072620391846,
2.7115893363952637
] |
['The extent to which parent variables are associated with the level of disability experienced by children with persistent pain has been an area of increasing research.', "To evaluate the extent to which parent perceptions of their child's vulnerability are associated with functioning and health care utilization among ... | qiaojin/PubMedQA | 1 | [
-2.0912578105926514,
1.3112382888793945,
0.11294029653072357
] |
['Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this association o... | qiaojin/PubMedQA | 2 | [
-1.9817299842834473,
-1.0998945236206055,
2.1004440784454346
] |
['Hyperbaric oxygen therapy is known to reduce fasting blood glucose in individuals with Type 2 diabetes. However, the mechanisms of this effect are not clear. The aim of this study was to determine whether peripheral insulin sensitivity by hyperinsulinaemic euglycaemic clamp is increased in patients presenting for hyp... | qiaojin/PubMedQA | 2 | [
-1.912772297859192,
-1.0475176572799683,
2.0185747146606445
] |
['Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT).', 'Our aim was to study the effects of POPs on human adipose cells and rodent AT.', 'Using human multipotent adipose-derived stem cells... | qiaojin/PubMedQA | 2 | [
-2.6198689937591553,
-1.089409351348877,
2.7302193641662598
] |
["Chronic kidney disease (CKD) is a major public health problem, and despite continued research in the field, there is still a need to identify both biomarkers of risk and progression, as well as potential therapeutic targets. Structural equation modeling (SEM) is a family of statistical techniques that has been utiliz... | qiaojin/PubMedQA | 2 | [
-2.582540273666382,
-0.3925594389438629,
2.1055784225463867
] |
['Curcumin (diferuloylmethane), the yellow pigment in the Asian spice turmeric, is a hydrophobic polyphenol from the rhizome of Curcuma longa. Because of its chemopreventive and chemotherapeutic potential with no discernable side effects, it has become one of the major natural agents being developed for cancer therapy.... | qiaojin/PubMedQA | 2 | [
-2.449639081954956,
-1.2233543395996094,
2.788640022277832
] |
["More severe and persistent forms of affective disorders are accompanied by grey matter loss in key frontal and temporal structures. It is unclear whether such changes precede the onset of illness, occur early in the course or develop gradually with persistence or recurrence of illness. A total of 47 young people pres... | qiaojin/PubMedQA | 2 | [
-2.1000895500183105,
0.5973363518714905,
0.6298320293426514
] |
['In HIV-infected patients, data on immunogenicity of Yellow fever immunization are scarce, and there is conflicting evidence of the influence of CD4 T-cell count and plasma HIV RNA on neutralizing antibody titer (NT) after vaccine injection.', 'In this prospective cohort study, NT was measured in all consecutive HIV o... | qiaojin/PubMedQA | 2 | [
-0.9163687229156494,
-1.6893585920333862,
1.699568271636963
] |
['Proline-rich tyrosine kinase 2 (Pyk2) is essential in neutrophil degranulation and chemotaxis in vitro. However, its effect on the process of lung inflammation and edema formation during LPS induced acute lung injury (ALI) remains unknown. The goal of the present study was to determine the effect of inhibiting Pyk2 o... | qiaojin/PubMedQA | 2 | [
-2.3934638500213623,
-1.4148564338684082,
2.841923236846924
] |
['Fractionated radiotherapy allows for the safe administration of larger doses without the development of immediate or late toxicity. The influence of preoperative fractionated radiotherapy on neointima formation for expanded polytetrafluoroethylene (ePTFE) graft has not been determined.', 'Twenty mongrel dogs were ran... | qiaojin/PubMedQA | 2 | [
-2.244657278060913,
-1.3763058185577393,
2.6584434509277344
] |
['High concentrations of methylated thiopurine metabolites, such as 6-methyl mercaptopurine, are associated with hepatotoxicity during administration of the conventional thiopurines azathioprine or 6-mercaptopurine in IBD patients. Metabolization of the non-conventional thiopurine 6-thioguanine does not generate 6-meth... | qiaojin/PubMedQA | 2 | [
-1.8447439670562744,
-1.5454294681549072,
2.4258615970611572
] |
['Hypoxia is a critical pathological factor in a variety of retinal diseases, including age-related macular degeneration. It upregulates angiogenic growth factors and promotes neovascularization. Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SIRT1). Activated SIRT1 signa... | qiaojin/PubMedQA | 2 | [
-2.2617478370666504,
-1.4538601636886597,
2.72710919380188
] |
['Helicobacter pylori has been shown to cause atrophic gastritis and intestinal metaplasia (IM), both of which are precancerous lesions. To clarify the mechanism by which H. pylori eradication prevents gastric cancer, we monitored atrophy and IM improvement in gastric mucosa over a long period after H. pylori eradicati... | qiaojin/PubMedQA | 2 | [
-1.1718688011169434,
-1.6496765613555908,
1.822434425354004
] |
['Results of meta-analyses typically conclude that future large studies may be mandated. However, the predictive ability of these estimates is deficient. We explored meta-analytic prediction intervals as means for providing a clear and appropriate future treatment summary reflecting current estimates.', 'A meta-epidemi... | qiaojin/PubMedQA | 2 | [
-1.6441789865493774,
-1.0413599014282227,
1.7368781566619873
] |
['Plasma triglyceride (TG) levels are known to confer an increased risk of vascular disease in healthy populations, but data in high-risk patients are scarce. In this study we evaluated the risk on recurrent vascular events conferred by increased plasma TG levels in patients with various clinical manifestations of vasc... | qiaojin/PubMedQA | 2 | [
-2.0824391841888428,
-1.3829467296600342,
2.476649761199951
] |
["Alzheimer's disease (AD) has a complex genetic etiology, and as a result many genes have been studied to determine how they might be involved with the disease. Amyloidogenic effects have been broadly linked with familial forms of the disease, though certain genes such as UBQLN1 could also play a role in prodromal pha... | qiaojin/PubMedQA | 2 | [
-1.6473581790924072,
-1.5708143711090088,
2.15202260017395
] |
['Severe ureteropelvic junction obstruction is treated surgically. However, for milder cases most clinical teams adopt a watchful waiting approach and only operate in the presence of significant decline of renal function combined with severe hydronephrosis. Little is known about the long-term consequences of ureteropel... | qiaojin/PubMedQA | 2 | [
-2.306156873703003,
-1.2102694511413574,
2.5999326705932617
] |
['Methotrexate (MTX) resistance is defined on the basis of the human chorionic gonadotropin (hCG) curve. The aim of this study was to identify low-risk non-metastatic patients with gestational trophoblastic neoplasia (GTN) who can achieve resolution by continuing MTX treatment despite a transient hCG plateau.', 'Before... | qiaojin/PubMedQA | 2 | [
-2.476243734359741,
-1.2693321704864502,
2.805835723876953
] |
['The aim is to assess the effect of survivin knockdown on the radio- and chemosensitivity of gastric cancer cells in vitro and in nude mice.', 'Survivin messenger RNA and protein were detected by semiquantitative reverse transcription-polymerase chain reaction and Western blot. Survivin and control small hairpin RNA (... | qiaojin/PubMedQA | 2 | [
-2.3728010654449463,
-1.367494821548462,
2.7893905639648438
] |
['Combination of multiple biomarkers representing distinct aspects of tumor biology will have a better prognostic value. This study was to identify prognostic subgroups of colon adenocarcinoma by combined analysis of synuclein-gamma (SNCG), a human homologue of piwi (Hiwi), phosphatase of regenerating liver-3 (PRL-3), ... | qiaojin/PubMedQA | 2 | [
-1.7133774757385254,
-1.6701993942260742,
2.4078316688537598
] |
['Previously, the authors demonstrated that the lack of the P2X(7) receptor impairs epithelial wound healing and stromal collagen organization in the cornea. The goal here is to characterize specific effects of the P2X(7) receptor on components of the corneal stroma extracellular matrix.', 'Unwounded corneas from P2X(7... | qiaojin/PubMedQA | 2 | [
-2.207602024078369,
-1.416312575340271,
2.6151506900787354
] |
['To investigate the roles of intracellular signaling elicited by Hedgehog (Hh) ligands in corneal maintenance and wound healing.', 'The expression of Hedgehog pathway components in the cornea was assayed by immunohistochemistry, western blot and reverse-transcription polymerase chain reaction (RT-PCR), in wild-type mi... | qiaojin/PubMedQA | 2 | [
-2.339838743209839,
-1.4054410457611084,
2.758066177368164
] |
['The Caenorhabditis elegans basic helix-loop-helix (bHLH) factor HLH-8, the single Twist ortholog in the nematode genome, plays important roles in mesoderm development, including M lineage patterning and differentiation of vulval and enteric muscles. HLH-8 cooperates with HLH-2, the bHLH E/Daughterless ortholog, to re... | qiaojin/PubMedQA | 2 | [
-2.4466519355773926,
-1.0833537578582764,
2.5611371994018555
] |
["Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Based on the associations of programmed death-1 (PD-1) protein encoding gene (PDCD1) with connective tissue diseases and vasculitides, PDCD1 polymorphisms are studied for susceptibility ... | qiaojin/PubMedQA | 2 | [
-2.2041308879852295,
-1.454277753829956,
2.7031774520874023
] |
['Replication-competent oncolytic viruses have shown great promise as a potential cancer treatment. This study aimed to determine whether a novel vaccinia virus, GLV-1h151, with genetic modifications enhancing cancer specificity and enabling virus detection, is effective against a range of human cancers and is safe whe... | qiaojin/PubMedQA | 2 | [
-2.314300298690796,
-1.3308088779449463,
2.7330355644226074
] |
['Although it is well known that adenovirus 36 (Ad36) is associated with obesity in humans as well as in animals, the detailed cellular mechanism is unclear.', 'Wild-type (WT) mice and monocyte chemoattractant protein-1 knockout (MCP-1(-/-)) mice were infected with Ad36, and their weights and inflammatory status were m... | qiaojin/PubMedQA | 2 | [
-2.2976338863372803,
-1.2223517894744873,
2.5733184814453125
] |
['Migraine headache is one of the most common neurological disorders, but the pathophysiology contributing to migraine is poorly understood. Intracranial interleukin-6 (IL-6) levels have been shown to be elevated during migraine attacks, suggesting that this cytokine may facilitate pain signaling from the meninges and ... | qiaojin/PubMedQA | 2 | [
-2.479018449783325,
-1.2856175899505615,
2.7468199729919434
] |
['We have previously found that atorvastatin decreases liver injury markers in patients with nonalcoholic steatohepatitis. However, how atorvastatin treatment ameliorates the disease activity in nonalcoholic steatohepatitis patients remains unknown.', 'We examined here which anthropometric, metabolic and inflammatory v... | qiaojin/PubMedQA | 2 | [
-2.3866071701049805,
-1.3896570205688477,
2.8323981761932373
] |
['Macrophages mediate the epithelial response to Helicobacter pylori and are involved in the development of gastritis. Sonic Hedgehog (Shh) regulates gastric epithelial differentiation and function, but little is known about its immunoregulatory role in the stomach. We investigated whether gastric Shh acts as a macroph... | qiaojin/PubMedQA | 2 | [
-2.387723922729492,
-1.3417115211486816,
2.795903205871582
] |
['Changes in brain derived neurotrophic factor (BDNF) expression have been associated with mood disorders and cognitive dysfunction. Transgenic models that overexpress or underexpress BDNF demonstrate similar deficits in cognition and mood. We explored the hypothesis that BDNF expression is controlled by balancing the ... | qiaojin/PubMedQA | 2 | [
-2.375742197036743,
-1.031264066696167,
2.443801164627075
] |
['Human and animal studies suggest that testosterone may have antidepressant effects. In this study, we sought to investigate the molecular mechanisms underlying the antidepressant effects of testosterone within the hippocampus, an area that is fundamental in the etiology of depression.', 'The effects of testosterone r... | qiaojin/PubMedQA | 2 | [
-2.686586618423462,
-0.8252666592597961,
2.4693171977996826
] |
["Murray's law describes the optimal branching anatomy of vascular bifurcations. If Murray's law is obeyed, shear stress is constant over the bifurcation. Associations between Murray's law and intravascular ultrasound (IVUS) assessed plaque composition near coronary bifurcations have not been investigated previously.",... | qiaojin/PubMedQA | 2 | [
-2.196842670440674,
-1.1201376914978027,
2.4411749839782715
] |
['Red blood cell transfusion is done primarily as a means to improve oxygen delivery (DO₂). Current transfusion guidelines are based solely on hemoglobin levels, regardless of actual DO₂ need. As central venous oxygen saturation (ScvO₂) may reflect imbalances in DO₂ and consumption (VO₂) the aim of this study was to in... | qiaojin/PubMedQA | 2 | [
-1.5395156145095825,
-1.7214555740356445,
2.226111650466919
] |
['The aim of this study was to describe anesthetic management and perioperative complications in patients undergoing pulmonary vein isolation for the treatment of atrial fibrillation under general anesthesia using high-frequency jet ventilation. The authors also identified variables associated with longer ablation time... | qiaojin/PubMedQA | 2 | [
-2.467406988143921,
-0.6305248141288757,
2.21612811088562
] |
['Studies suggest that altered immune activation, manifested by an imbalance in anti- and pro-inflammatory cytokine levels, exists in a subgroup of irritable bowel syndrome (IBS) patients. However, similar studies have not been conducted in Latin populations. The objective of this study was to measure serum levels of i... | qiaojin/PubMedQA | 2 | [
-1.2988812923431396,
-1.586118459701538,
1.8125578165054321
] |
['To determine optimal timing of assessing postradiation radiographic response on magnetic resonance imaging (MRI) scans in pediatric patients with diffuse intrinsic pontine glioma (DIPG).', 'Patients were treated on a prospective study at the National Cancer Institute (Protocol #06-C-0219) evaluating the effects of ra... | qiaojin/PubMedQA | 2 | [
-1.8303083181381226,
-1.561604619026184,
2.470973253250122
] |
['The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent on microtubules. p150(Glued), a subunit of dynactin, has been implicated in the transport of COPII vesicles via its interaction with COPII coat component... | qiaojin/PubMedQA | 2 | [
-2.3284895420074463,
-0.834435760974884,
2.211808919906616
] |
['Low admission Norton scale scores (ANSS) are usually associated with high risk of pressure ulcer. The aim of this study was to determine whether low ANSS are also associated with long-term mortality following rehabilitation in older adults.', 'A cross-sectional retrospective study.', 'Consecutive older adults admitte... | qiaojin/PubMedQA | 2 | [
-0.9011515378952026,
-1.2206670045852661,
1.1134971380233765
] |
['AIM. This study was designed to examine whether the class I and class IIa histone deacetylase (HDAC) inhibitors, sodium butyrate and sodium valproate alter the expression of human NCOR1 and/or NCOR2 genes coding for N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone rec... | qiaojin/PubMedQA | 2 | [
-2.3644587993621826,
-1.3390395641326904,
2.7456552982330322
] |
['The Eustachian valve (EV) is an embryonic structure redirecting the blood flow from the inferior vena cava through the foramen ovale. It may persist in adults as a floating membrane in the right atrium. A large EV can be associated with thrombosis, embolization, bacterial endocarditis, etc. The prevalence of EV in th... | qiaojin/PubMedQA | 2 | [
-1.2751294374465942,
-1.5509577989578247,
1.8665404319763184
] |
['Functional cartilage tissue engineering aims to generate grafts with a functional surface, similar to that of authentic cartilage. Bioreactors that stimulate cell-scaffold constructs by simulating natural joint movements hold great potential to generate cartilage with adequate surface properties. In this study two me... | qiaojin/PubMedQA | 2 | [
-2.504765033721924,
-1.1657743453979492,
2.829176664352417
] |
['Gene therapy of the heart has been attempted in a number of clinical trials with the injection of naked DNA, although quantitative information on myocellular transfection rates is not available. The present study aimed to quantify the efficacy of electropulsing protocols that differ in pulse duration and number to st... | qiaojin/PubMedQA | 2 | [
-2.1582438945770264,
-1.4733105897903442,
2.6263442039489746
] |
['Oxidative stress has been shown to play an important role in cancer progression. In lung cancer, increasing expression of caveolin-1 (Cav-1) has been found in both primary and metastatic carcinomas and may be critical in the regulation of the oxidative status of cancer cells.', 'Using molecular and pharmacological ma... | qiaojin/PubMedQA | 2 | [
-2.563054323196411,
-1.1337730884552002,
2.741354465484619
] |
['C-reactive protein (CRP) has been associated with the development of many carcinomas, but the significance of CRP remains unclear for metastatic gastric cancer (MGC).', 'Sixty one patients who received S-1 plus cisplatin for MGC were retrospectively identified and categorized into two groups depending on the serum CR... | qiaojin/PubMedQA | 2 | [
-1.5114737749099731,
-1.5223495960235596,
2.0898847579956055
] |
['Inhibition of signal transduction pathways has been successfully introduced into cancer treatment. The dual phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 has antitumor activity in vitro against solid tumors. Here, we examined the activity of NVP-BEZ235 in acute lym... | qiaojin/PubMedQA | 2 | [
-2.3941941261291504,
-1.3398487567901611,
2.7440686225891113
] |
['Cyclin G1 deficiency is associated with reduced incidence of carcinogen-induced hepatocellular carcinoma (HCC), but its function in HCC progression remains obscure. We report a critical role of cyclin G1 in HCC metastasis. Elevated expression of cyclin G1 was detected in HCCs (60.6%), and its expression levels were e... | qiaojin/PubMedQA | 2 | [
-2.381240129470825,
-1.339362382888794,
2.757244348526001
] |
['We evaluated the in vitro activity of a merochlorin A, a novel compound with a unique carbon skeleton, against a spectrum of clinically relevant bacterial pathogens and against previously characterized clinical and laboratory Staphylococcus aureus isolates with resistance to numerous antibiotics.', 'Merochlorin A was... | qiaojin/PubMedQA | 2 | [
-2.5312232971191406,
-1.207863211631775,
2.846069812774658
] |
['Evidence links dietary sodium to hypertension and cardiovascular disease (CVD), but investigation of its influence on cardiovascular function is limited.', 'We examined the relation between habitual dietary sodium and coronary flow reserve (CFR), which is a measure of overall coronary vasodilator capacity and microva... | qiaojin/PubMedQA | 2 | [
-1.6723757982254028,
-1.5641841888427734,
2.20782208442688
] |
['The effect of hormone replacement therapy (HRT) in postmenopausal women on the development of peripheral atherosclerosis remains in question. The goal of this study was to analyze the use of HRT in a large population of postmenopausal women and to determine its association with the prevalence of peripheral arterial d... | qiaojin/PubMedQA | 2 | [
-1.6852203607559204,
-1.4111782312393188,
2.0394692420959473
] |
['The outcome of patients undergoing surgical or interventional therapy is unfavourably influenced by severe systemic inflammation. We assessed the impact of a systemic inflammatory response syndrome (SIRS) on the outcome after transcatheter aortic valve implantation (TAVI).', 'One hundred and fifty-two high-risk patie... | qiaojin/PubMedQA | 2 | [
-1.946980595588684,
-1.581475019454956,
2.5582852363586426
] |
['In the brain, the enzyme catalase by reacting with H(2)O(2) forms Compound I (catalase-H(2)O(2) system), which is the main system of central ethanol metabolism to acetaldehyde. Previous research has demonstrated that acetaldehyde derived from central-ethanol metabolism mediates some of the psychopharmacological effec... | qiaojin/PubMedQA | 2 | [
-2.3509833812713623,
-1.1914341449737549,
2.558737277984619
] |
['The integration of host genetics, environmental triggers and the microbiota is a recognised factor in the pathogenesis of barrier function diseases such as IBD. In order to determine how these factors interact to regulate the host immune response and ecological succession of the colon tissue-associated microbiota, we... | qiaojin/PubMedQA | 2 | [
-2.6905734539031982,
-0.8911685943603516,
2.6981711387634277
] |
['The aim of this study was to determine (1) the effect of various scan delays on pixel intensity measurements and (2) the diagnostic accuracy of occlusal caries detection.', '72 non-cavitated extracted human permanent molar teeth with sound and carious occlusal surfaces were radiographed using the DIGORA® storage phos... | qiaojin/PubMedQA | 2 | [
-1.2224414348602295,
-1.6478891372680664,
1.948904275894165
] |
['The etiology of Condylar hyperplasia (CH) of human temporomandibular joint (TMJ) remains largely unknown. Our previous study has demonstrated that enriched insulin-like growth factor-1(IGF-1) was expressed in the proliferation and hypertrophic layers of CH cartilage. Accordingly, this study was aimed to investigate w... | qiaojin/PubMedQA | 2 | [
-2.3834891319274902,
-1.352290391921997,
2.7907235622406006
] |
["What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical prostatectomy are common, although their impact on the risk of disease recurrence is unknown. We examined the impact of PSMs on the risk of 'significant' biochemical recurrence stratified by their risk of occult m... | qiaojin/PubMedQA | 2 | [
-1.587234616279602,
-1.4554734230041504,
2.076845645904541
] |
['Idiopathic and inflammation-dependent fibrotic diseases such systemic sclerosis (SSc) impose a major burden on modern societies. Understanding endogenous mechanisms, which counteract fibrosis, may yield new therapeutic approaches. Lipoxins are highly potent lipid mediators, which have recently been found to be decrea... | qiaojin/PubMedQA | 2 | [
-2.4238345623016357,
-1.2655836343765259,
2.6929399967193604
] |
['Reverse cholesterol transport (RCT) is a major antiatherogenic function of high density lipoprotein (HDL). In the current work, the authors evaluated whether the RCT capacity of HDL from rheumatoid arthritis (RA) patients is impaired when compared to healthy controls.', "HDL was isolated from 40 patients with RA and ... | qiaojin/PubMedQA | 2 | [
-1.5245683193206787,
-1.6749670505523682,
2.108729124069214
] |
['When performing cholecystectomy after gastrectomy, we often encounter problems, such as adhesions, nutritional insufficiency, and bowel reconstruction. The purpose of this study was to identify the factors related to surgical outcome of these associated procedures, with emphasis on the use of a laparoscopic approach.... | qiaojin/PubMedQA | 2 | [
-1.8714655637741089,
-1.4504698514938354,
2.3848283290863037
] |
['Persistent allergic rhinitis (PER) has a moderate impact on the sense of smell, but no controlled study has reported the effect of antihistamines on the loss of smell in patients with PER.', 'Patients with PER and subjective loss of the sense of smell (n = 27) were included in this pilot randomised, double-blind, pla... | qiaojin/PubMedQA | 2 | [
-1.9526699781417847,
-1.5283198356628418,
2.4552090167999268
] |
['It is well known that port-wine stains of the upper part of the face may herald abnormalities of the brain or eye in the form of Sturge-Weber syndrome. This study focuses on other extracutaneous anomalies in patients with nevi flammei of the head and neck, giving rise to functional complications.', 'A retrospective s... | qiaojin/PubMedQA | 2 | [
-2.4400322437286377,
-1.244394063949585,
2.755764961242676
] |
['A-to-I RNA editing is found in all phyla of animals and contributes to transcript diversity that may have profound impacts on behavior and physiology. Many transcripts of genes involved in axonal conductance, synaptic transmission and modulation are the targets of A-to-I RNA editing. There are a number of methods to ... | qiaojin/PubMedQA | 2 | [
-1.6737443208694458,
-1.0930211544036865,
1.7159863710403442
] |
['We investigated the roles of neuronal-derived nitric oxide (NO) in the modulation of spontaneous activity of mouse detrusor smooth muscle.', 'Detrusor smooth muscle strips were isolated from nNOS gene knock-out (nNOS(-/-) ) mice and their wild type siblings (nNOS(+/+) ). The properties of smooth muscle cells were ass... | qiaojin/PubMedQA | 2 | [
-2.2695982456207275,
-1.3892263174057007,
2.7089786529541016
] |
['Loss of clinical attachment and alveolar bone destruction are major symptoms of periodontitis, caused by not only the destructive effect of periodontopathic bacteria but also the overactive response of the host immune system against periodontal pathogens. The details of the participation of the immune system in the o... | qiaojin/PubMedQA | 2 | [
-2.5466361045837402,
-1.1687239408493042,
2.8149633407592773
] |
['We have recently found that Wnt-5a regulates the synaptic structure and function in hippocampal neurons. This ligand is expressed in the hippocampus, stimulates dendritic spine morphogenesis and increases glutamatergic neurotransmission. Moreover, we have also shown that Wnt-5a induces the clustering of PSD-95.', 'To... | qiaojin/PubMedQA | 2 | [
-2.5161678791046143,
-1.127095103263855,
2.635596990585327
] |
['Thrombin activatable fibrinolysis inhibitor (TAFI) has been reported to be involved in the pathogenesis and progression of inflammatory bowel disease (IBD). Activated TAFI (TAFIa) attenuates fibrinolysis by cleaving C-terminal lysine residues thus down-regulating plasminogen activation. To date, no reports on TAFIa i... | qiaojin/PubMedQA | 2 | [
-2.2689313888549805,
-1.3773291110992432,
2.6304619312286377
] |
['To compare the biological, technical and aesthetic outcomes of single implant-supported all-ceramic versus metal-ceramic crowns.', 'Thirty-six patients with premolar agenesis were randomly treated with 38 all-ceramic (AC) and 37 metal-ceramic (MC) implant-supported single-tooth restorations. A quasi-randomisation of ... | qiaojin/PubMedQA | 2 | [
-1.4931894540786743,
-1.6734952926635742,
2.1860039234161377
] |
['This study was carried out to identify the occurrence, type, location, and severity of dental injuries (DIs), as well as predictors for DIs, in pediatric patients with facial fractures.', 'This study examined the files of patients aged 16 years or less who had sustained facial fractures during a 12-year period. The o... | qiaojin/PubMedQA | 2 | [
-1.730950951576233,
-0.9061371088027954,
1.6768152713775635
] |
['Epigenetic changes in DNA methylation have recently been demonstrated to be involved in effector T-cell polarization, resulting in differential secretion of T(H)1 and T(H)2 cytokines. However, the contribution to the development of a chronic inflammatory phenotype remains still unclear.', 'We sought to investigate ch... | qiaojin/PubMedQA | 2 | [
-2.5064895153045654,
-1.1777549982070923,
2.7434098720550537
] |
['IL-9-secreting (T(H)9) T cells are thought to represent a distinct T-cell subset. However, evidence for their functionality in disease is uncertain.', 'To define a functional phenotype for T(H)9-driven pathology in vivo.', 'We used fluorescence-activated cell sorting to identify circulating T(H)9 cells in atopic and ... | qiaojin/PubMedQA | 2 | [
-2.658607006072998,
-1.037517786026001,
2.701908588409424
] |
['The mechanisms underlying the effects of estrogen on endometrial cancer remain undefined. Although the classical mechanism of the action of estrogen involves binding to the estrogen receptors α and β, and transduction of the signal into the cell, G protein-coupled receptor (GPR) 30 has been shown to mediate nongenomi... | qiaojin/PubMedQA | 2 | [
-2.545480489730835,
-1.0700924396514893,
2.6472742557525635
] |
['The purpose of this study was to determine whether, in surgical infants requiring parenteral nutrition (PN), septicaemia due to enterococci or Gram-negative bacilli occurs later than septicaemia due to coagulase-negative staphylococci (CNS).', "We retrospectively studied 112 consecutive surgical infants (corrected ge... | qiaojin/PubMedQA | 2 | [
-1.5994623899459839,
-1.2033634185791016,
1.9585705995559692
] |
['This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors.', 'The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49... | qiaojin/PubMedQA | 2 | [
-2.265744209289551,
-0.8580959439277649,
2.2619056701660156
] |
['Toll-like receptors (TLRs) are expressed by a variety of cells, including intestinal epithelia. However, the full spectrum of regulators modulating innate responses via TLRs has not been delineated. Tribbles (Trib) have been identified as a highly conserved family of kinase-like proteins. We sought to clarify the rol... | qiaojin/PubMedQA | 2 | [
-2.26735258102417,
-1.2228492498397827,
2.5166759490966797
] |
['We had shown that dienogest (DNG) + testosterone undecanoate (TU) induced complete sperm suppression in rats when administered together every 45 days. On the other hand, individual drugs given alone in a similar fashion failed to achieve the same result.', 'The present study was therefore undertaken to determine the ... | qiaojin/PubMedQA | 2 | [
-2.454263925552368,
-1.2693524360656738,
2.7662696838378906
] |
['Recent studies suggest that tumor microenvironment (stroma) is important in carcinogenesis and progression. We sought to integrate global genomic structural and expressional alterations in prostate cancer epithelium and stroma and their association with clinicopathologic features.', 'We conducted a genome-wide LOH/al... | qiaojin/PubMedQA | 2 | [
-2.1548452377319336,
-1.3266770839691162,
2.544050931930542
] |
['To determine the prevalence and clinical significance of carotid sinus syndrome (CSS) and vasovagal syncope (VVS), the two common types of Neurally Mediated Syncope (NMS), in a cohort of older patients with unexplained falls.', 'Patients presenting with unexplained and accidental falls were identified from 200 consec... | qiaojin/PubMedQA | 2 | [
-1.8940273523330688,
-0.7422744631767273,
1.6463220119476318
] |
['Compensatory trunk movements during gait, such as a Duchenne limp, are observed frequently in subjects with osteoarthritis of the hip, yet angular trunk movements are seldom included in clinical gait assessments. Hence, the objective of this study was to quantify compensatory trunk movements during gait in subjects w... | qiaojin/PubMedQA | 2 | [
-1.8419550657272339,
-0.9463759064674377,
1.8840444087982178
] |
['Nicotinic acid (NA) treatment has been associated with benefits in atherosclerosis that are usually attributed to effects on plasma lipoproteins. The NA receptor GPR109A is expressed in monocytes and macrophages, suggesting a possible additional role for NA in modulating function of these immune cells. We hypothesize... | qiaojin/PubMedQA | 2 | [
-2.1665022373199463,
-1.4152448177337646,
2.5957930088043213
] |
['Transforming growth factor-β1 (TGF-β1) is a profibrotic cytokine that plays a major role in vascular biology, and is known to regulate the phenotype and activity of various vascular cell populations. Because most fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), are associated with vascular remodeling, ... | qiaojin/PubMedQA | 2 | [
-2.426983118057251,
-1.2345221042633057,
2.671994686126709
] |
['We investigated axonal plasticity in the bilateral motor cortices and the long term therapeutic effect of Niaspan on axonal remodeling after stroke in type-1 diabetic (T1DM) rats.', 'T1DM was induced in young adult male Wistar rats via injection of streptozotocin. T1DM rats were subjected to 2h transient middle cereb... | qiaojin/PubMedQA | 2 | [
-2.193058490753174,
-1.4708696603775024,
2.6606369018554688
] |
["Circadian mechanisms play an important role in the regulation of sleep. A circadian clock-controlled gene, Tef, has been suggested to be associated with depressive symptoms, restless legs syndrome, and slow wave sleep in patients with sleep disorders. The present study sought to explore the association between Tef an... | qiaojin/PubMedQA | 2 | [
-1.7293345928192139,
-1.2243602275848389,
2.032991409301758
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.