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[ "plasma cell leukemia ( pcl ) is a rare disease that represents approximately 4% of plasma cell malignant disorders.1 diagnosis of pcl is established based on kyle s criteria , which includes an absolute plasma cell number accounting for greater than 2000/l or 20% of white blood cell differentiation.2 pcl consists ...
plasma cell leukemia ( pcl ) is a rare disease that represents approximately 4% of plasma cell malignant disorders . pcl consists of two variants : primary pcl presents in patients with no previous history of multiple myeloma , while secondary pcl consists of a leukemic transformation in a previously recognized multipl...
[ "fitz hugh curtis syndrome is an extra - pelvic manifestation of pelvic inflammatory disease ( pid ) and is characterized by perihepatic adhesions between liver capsule and diaphragm or anterior peritoneal surface(13 ) . most fitz hugh curtis syndrome patients are women of child bearing age and rarely has the s...
fitz hugh curtis syndrome is a condition characterized by inflammation of the liver capsule with concomitant pelvic inflammation without involvement of liver parenchyma . it is classically seen in young women who present with sharp , pleuritic right upper quadrant pain , usually but not always accompanied by symptoms...
[ "chemical shifts are now routinely used as a source of local conformational restraints in the structure determination of proteins by nmr , due mostly to the widespread use of programs such as talos ( cornilescu et al . 1999 ) and shiftor / preditor ( neal et al . 2006 ; berjanskii et al . 2006 ) . these programs sh...
we present simshiftdb , a new program to extract conformational data from protein chemical shifts using structural alignments . the alignments are obtained in searches of a large database containing 13,000 structures and corresponding back - calculated chemical shifts . simshiftdb makes use of chemical shift data to pr...
[ "sutureless clear corneal incisions are now arguably the most common incisions made to perform cataract surgery with phacoemulsification , replacing scleral tunnel and limbal incisions . there are significant differences in the effects of clear corneal and scleral or limbal incisions , related to anatomical and phy...
purpose . to compare the surgically induced astigmatism from clear corneal and square posterior limbal incisions at the time of cataract surgery . methods . surgically induced astigmatism was calculated for a set of eyes after cataract surgery using a temporal 2.2 mm square posterior limbal incision . results were c...
[ "the embryonic development of the cerebellum derives from the hindbrain from the fifth week , originating from the thickening of the dorsal alar plates . anatomically it is formed by a median portion , the vermis , connected to two large lateral masses , the cerebellar hemispheres . the cisterna magna is located in...
to compare the fetal cerebellum and cisterna magna length measurements by means of two- ( 2dus ) and three - dimensional ( 3dus ) ultrasonography using the three - dimensional extended imaging ( 3d xi ) , a cross - sectional study with 69 healthy pregnant women between 18 and 24 weeks was performed . for the measuremen...
[ "the protocol for this cross - sectional study was reviewed and approved by the institutional ethical committee for clinical research at the geneva university hospitals . all patients who had received a whole pancreas or an islet of langerhans transplant at the geneva university hospitals and who had regular follow...
objective-cells have demonstrated altered proinsulin processing after islet transplantation . we compare -cell metabolic responses and proinsulin processing in pancreas and islet transplant recipients with respect to healthy control subjects.research design and methodswe studied 15 islet and 32 pancreas transplant reci...
[ "we have demonstrated that , melatonin is a bioprecursor of hypnotic acetyl metabolites produced by enzymatic acetylation of melatonin and 2-oxomelatonin under the control of acetyltransferases , most probably the nat enzymes . in 1994 , in our laboratory , we developed a specific and highly sensitive gas chromatog...
pharmacokinetic studies of melatonin in young and elderly human volunteers , and the measurement of hypnotic effects in chicks under alternate light - dark or permanent light conditions , show that melatonin is a bioprecursor of hypnotic acetyl metabolites produced by the enzymatic acetylation of both melatonin and 2-o...
[ "\n over the next several decades , the number of americans living to advanced ages will increase substantially . although many individuals will age in relatively good health , a growing number will encounter challenges associated with the burdens of chronic conditions and associated disabilities [ 13 ] . this is e...
previous research emphasizes the importance of reducing healthcare frustrations and enhancing physician supports to help patients engage in recommended healthcare regimens . however , less is known about how these factors are associated with aging women 's knowledge about self - care behavior . this study examined the ...
[ "patients with schizophrenia ( scz ) exhibit a wide variety of cognitive deficits , particularly with memory ( barch and ceaser , 2012 ; ranganath et al . , 2008 ) . these deficits are predictive of overall functional outcome and clinical remission ( bodnar et al . , 2008 ; green , 2006 ; green et al . , 2004 ; kah...
source memory , the ability to identify the context in which a memory occurred , is impaired in schizophrenia and has been related to clinical symptoms such as hallucinations . the neurobiological underpinnings of this deficit are not well understood . twenty - five patients with recent onset schizophrenia ( within the...
[ "ras is a multifunctional signaling molecule acting as an essential component of signal transduction pathways that regulate cellular physiology ( campbell et al . members of the ras family of proteins that are constitutively activated by point mutations play a major role in the onset of a large number of human canc...
constitutively activated ras proteins are associated with a large number of human cancers , including those originating from skeletal muscle tissue . in this study , we show that ectopic expression of oncogenic ras stimulates proliferation of the mm14 skeletal muscle satellite cell line in the absence of exogenously ad...
[ "lipomas represent uncommon neoplasms of the oral cavity ; only 1% to 5% of cases occur at this site . based on their histopathological features of conspicuous multiple components , lipomas can be divided into some subclasses [ 2 , 3 ] , and the most common is the fibrolipoma [ 1 , 3 , 4 ] . cases reporting on lipo...
the purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma / fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity . two cases of the tumors , who presented with a painless , relatively hard mass on the oral mucosa , were studie...
[ "leydig cell tumours are rare stromal tumours of the testis accounting for 13% of testicular neoplasms . they exhibit a peak incidence in the preadolescent as well as in the older ( > 50 years ) age groups [ 1 , 2 , 3 , 4 ] . the diagnosis of a malignant leydig cell tumour is not always easy since no definite histo...
leydig cell tumour is a benign testicular non - germ cell tumour , and malignant transformation is rare . we report a case of a 35-year - old man who came to our hospital with a painless left testicular mass measuring 1.2 1 cm . histological evaluation of the tumour showed features of a malignant leydig cell tumour bu...
[ "the prevalences of asthma , allergic rhinitis and allergic eye disease in antalya , on the south coast of turkey , have been reported as 8.2% , 10.8% and 7.5% , respectively . allergic diseases are most likely due to complex interactions between largely unknown genetic and environmental factors [ 36 ] . the micro ...
summarybackgroundallergic rhinitis is a common health problem affecting the immune system . the homeostasis of the immune system is regulated by apoptosis . in this study , serum circulating soluble trail levels of allergic rhinoconjunctivitis patients before and after allergen - specific immunotherapy were evaluated.m...
[ "calcimimetics provide an alternative approach to the traditional therapy with active vitamin d and phosphate binders for the management of secondary hyperparathyroidism ( shpt ) . type ii calcimimetics are positive allosteric modulators of the parathyroid gland calcium - sensing receptor ( car ) that increase its ...
standard therapy for secondary hyperparathyroidism ( shpt ) includes dietary calcium supplementation , active vitamin d , and phosphate binders ; however , these are often insufficient to allow patients to achieve their serum parathyroid hormone ( pth ) , calcium and calcium phosphorus product ( ca p ) targets . rece...
[ "many neurodegenerative disorders are characterized by \n their presence in neural tissue of aberrant protein aggregates \n ( see table 1 ) . in general , these aggregates arise after the modification of a \n native protein . that modification could result in a conformational \n change of the native protein that pr...
protein aggregation takes place in many neurodegenerative disorders . however , there is a controversy about the possible toxicity of these protein aggregates . in this review , this controversy is discussed , focussing on the tau aggregation that takes place in those disorders known as tauopathies .
[ "only those contraceptive methods are new in which synthetic steroid is used . regarding the current status of growth , the world population is doubled every 54 years ; however , in poor countries , population is doubled in less than 20 years . to complete and preserve personal health during pregnancy , the optimal...
we aimed to find the prevalence and some factors relating with unwanted pregnancy . methods . it was a cross - sectional study on 400 randomly pregnant women , who were referring to different health centers in ahwaz city during 20...
[ "at the end of past millennium , flexible bronchoscopy was regarded as one of the most frequently performed procedures by the physicians of multiple disciplines to inspect the airway . in our institute , the fibreoptic bronchoscopies are performed by either the pulmonologists or the anaesthetist . at many places , ...
aim : the aim of the study was to compare transcricoid injection with spray as you go technique for diagnostic fibreoptic bronchoscopy , to perform the procedure without sedation and to record any complication or side effects.methods:sixty patients belonging to the age group 2070 years , undergoing diagnostic bronchosc...
[ "charcot - marie - tooth disease ( cmt ) is the most common hereditary motor and sensory neuropathy , and cmt type 1a ( cmt1a ) neuropathy , which is the most common type of cmt , is subject to a gene dosage effect.1 the primary genetic cause of cmt1a is a duplication of pmp22 resulting from the unequal crossover b...
background and purposecharcot - marie - tooth disease ( cmt ) type 1a ( cmt1a ) is the demyelinating form of cmt that is significantly associated with pmp22 duplication . some studies have found that the disease - related disabilities of these patients are correlated with their compound muscle action potentials ( cmaps...
[ "a negative balance between the formation and resorption of bone mass can lead to the development of osteoporosis . moreover , osteoporosisis characterized by skeletal fragility resulting from reduced bone mass and disrupted bone microarchitecture . osteoporosis increases the risk of fracture and thus has been cons...
abstractthe effect of hepatitis c virus ( hcv ) exposure on bone mineral density without advanced liver disease remains debated . thus , we assessed the relation between hcv exposure and the risk of osteoporosis.from 2000 to 2011 , patients aged > 20 years with hcv exposure were identified from the longitudinal health ...
[ "each disaster leaves an imprint on the affected population , a singular signature . a critical unmet need in the field of disaster mental / behavioral health is the capability to tailor mental health and psychosocial support ( mhpss ) to the unique constellation of psychological risk factors operating within eac...
trauma signature ( tsig ) analysis is an evidence - based method that examines the interrelationship between population exposure to a disaster , extreme event , or complex emergency , and the inter - related physical and psychological consequences for the purpose of providing timely , actionable guidance for effective ...
[ "cerebrovascular diseases ( cvds ) are associated with balance disturbances , dependency in \n performing daily living activities , and limited ambulation . as life expectancy increases spasticity is a speed - dependent resistance to the passive motion of muscles and tendons , \n developing secondary to enhanced st...
to investigate whether transcutaneous electrical nerve stimulation ( tens ) mitigates the spasticity of hemiplegic stroke patients , as assessed by electrophysiological variables , and the effects , if any , on the clinical appearance of spasticity . [ subjects and methods ] twenty - seven subjects who had acute ...
[ "proteinase - activated receptors ( pars ) belong to a family of g - protein - coupled receptors with seven transmembrane domains activated via proteolytic cleavage by serine proteinases . a total of four pars have been identified and cloned . among them , par-1 [ 2 , 3 ] , par-3 , and par-4 are targets for throm...
serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors ( pars ) . however , little is known about the influence of serine proteinases and pars on tnf secretion from highly purified t cells . we challenged t cells from human peripheral blood with serine pr...
[ "relapsing chronic inflammation found in the gut of individuals affected by inflammatory bowel diseases ( ibd ) is a result of several overlapping factors , including dysregulation of the immune response to the enteric microbiota , genetic susceptibility , and environmental factors [ 1 , 2 ] . reactive oxygen ( ros...
reactive oxygen species ( ros ) and nitrogen species have an indispensable role in regulating cell signalling pathways , including transcriptional control via hypoxia inducible factor-1 ( hif-1 ) . hyperbaric oxygenation treatment ( hbo2 ) increases tissue oxygen content and leads to enhanced ros production . in the pr...
[ "sexuality in women is a complex issue with physiological , psychological , and cultural components . determination of sexual partner involvement , intimate relationships , and past abusive relationships is crucial in female sexual dysfunction ( fsd ) ( 1 , 2 ) . sexual dysfunction is more prevalent among women com...
backgroundopiate abuse in males has significant effects on their sexual functions . in contrast , sexuality in females is a multidimensional issue that can strongly be affected by several factors in their partners . however , only a limited number of studies have assessed the role of males opioid dependency in their fe...
[ "laparoscopic surgery has gained widespread acceptance in a variety of procedures , ranging from gastric fundoplication to cholecystectomy . although laparoscopic appendectomy ( la ) is more expensive than is open appendectomy ( oa ) due to the costs of the disposable equipment , and can be more technically challen...
background : laparoscopic surgery has reduced the length of hospital stay for common operations like cholecystectomy , gastric fundoplication , and appendectomy . we have noticed a reduction in length of hospital stay for children undergoing laparoscopic appendectomy . we , therefore , looked at our data to assess whet...
[ "a major effort in the nucleocytoplasmic transport field has been directed towards the analysis of all members of the importin family , in particular with the aim of identifying specific transport cargoes . this has led to the characterization of a large number of related proteins ( both importins and exportins ) ...
the importin--like family of nuclear transport receptors mediates the transport of a large number of substrates between the cytoplasm and the nucleus . the family is made up of importins and exportins which shuttle between the nucleus and the cytoplasm and are regulated by the small gtpase ran .
[ "musculoskeletal conditions , or disorders of the muscles and bones , are the most common causes of chronic disability in the world . in the us alone , disease of the musculoskeletal system was the primary diagnosis during 83,228,000 office visits in 2009 ( 8.0% of total visits ) . a stroke can also cause many of t...
robotic rehabilitation systems have been developed to treat musculoskeletal conditions , but limited availability prevents most patients from using them . the objective of this paper was to create a home - use robotic rehabilitation system . data were obtained in real time from a microsoft \documentclass[12pt]{minimal ...
[ "international diabetic federation estimated that in india there are 66.8 million patients in 2013 , with nearly 50% undiagnosed . diabetes was related to one million deaths and mortality was higher under age of 60 years . by 2030 there will more than 79 million diabetics , making it one of the major public health ...
introduction : diabetes is an important public health problem of india . studies have shown that increase in patients knowledge regarding the disease results in better compliance to treatment and decrease in complications . this study was planned to assess the knowledge about diabetes and its correlation with pharmacol...
[ "lactic acid was first found and described in sour milk by the swedish chemist karl wilhelm scheele ( 17421786 ) in 1780 . the swedish chemist jns jakob berzelius ( 17791848 ) found lactic acid in fluid extracted from meat in 1808 [ 2 , 3 ] , and the german chemist justus von liebig ( 18031873 ) , who established...
lactic acid was first found and described in sour milk by karl wilhelm scheele ( 17421786 ) in 1780 . the german physician chemist johann joseph scherer ( 18411869 ) demonstrated the occurrence of lactic acid in human blood under pathological conditions in 1843 and 1851 . in this article we honour the forgotten observ...
[ "panax ginseng ( ginseng ) has been used traditionally in eastern asia over thousands of years . it has been used orally to treat various diseases including hypertension , diabetes mellitus , liver and kidney dysfunction , mental disorders , and postmenopausal disorders . in addition , topical applications have als...
abnormal changes in skin color induce significant cosmetic problems and affect quality of life . there are two groups of abnormal change in skin color ; hyperpigmentation and hypopigmentation . hyperpigmentation , darkening skin color by excessive pigmentation , is a major concern for asian people with yellow brown sk...
[ "chronic kidney disease ( ckd ) is associated with a number of comorbidities and prognosis is poor , because many patients experience progression to end - stage renal disease . also , in the majority of patients disease progression may be altered due to more or less suitable immunosuppressive protocol treatments an...
objectives . retrospective study was designed to examine the importance of tissue kidney injury molecule-1 ( kim-1 ) expression in predicting kidney function in sixty patients ( 27 males ) aged 34.15 12.23 years with different kidney diseases over three years after kidney biopsy . materials and methods . tissue kim-...
[ "these range from various slow - growing benign tumors and low - grade malignancies to fast growing high - grade malignancies . angiofibromas are one such group of tumors arising in this region , which present as swellings . of these , nasal angiofibromas ( nas ) are the most common and nas occurring in the region ...
angiofibromas are rare , benign , locally invasive vascular tumors , which represent 0.05 - 0.5% of all head and neck tumors . most frequent site of occurrence is the posterior nasopharynx , called as nasopharyngeal angiofibromas ( na ) , when these arise outside the nasopharyngeal region they are termed as extranasoph...
[ "atherosclerotic renal artery hypertension is reported in almost 7% of adults older than 65 years1 ) and is associated with cardiovascular events , and may double risk of mortality2 ) . in the 1990s , radiological angioplasty began to replace surgical revascularization . galaria et al . showed that percutaneous and...
atherosclerotic renovascular hypertension is a form of secondary hypertension due to renal artery stenosis . after the introduction of medical therapy such as with statins and angiotensin blocking agents , it has been considered a very slowly progressive disease . in the 1990s , surgical methods were compared to radiol...
[ "tuberculosis ( tb ) caused by mycobacterium tuberculosis ( m. tb ) continues to be a significant global health problem , affecting millions of people worldwide [ 1 , 2 ] . it is a prevalent infectious disease in china , with 250,000 deaths from tb annually and 6 million active tb patients at present . the global i...
one approach for improving bcg efficacy is to utilize bcg as vehicle to develop recombinant bcg ( rbcg ) strains overexpressing mycobacterium tuberculosis ( m. tb ) antigens . also expression level of a candidate antigen should impact the final t cell responses conferred by rbcg . in this study , based on our previousl...
[ "a 6-year - old boy presented with a history of penetrating injury to the upper left eyelid sustained while diving head - first into a pond . on presentation , he could only perceive hand movements very close to his face . since a computed tomography ( ct ) scan done at this time did not reveal the presence of any ...
diving into lakes and ponds is a common activity of rural children . we present two cases of penetrating orbital injuries from plant matter sustained in this manner . such injuries pose a particular challenge because wooden foreign bodies are often missed during orbital exploration , and current imaging modalities can ...
[ "postcataract surgery endophthalmitis is a relatively uncommon but devastating complication of modern cataract surgery , and there is not complete consensus regarding the ideal practice patterns for prophylaxis . the european society of cataract and refractive surgeons ( escrs ) prospective multi - center intervent...
background : endophthalmitis after cataract surgery is a rare but vision - threatening complication . intracameral cefuroxime ( icc ) has been reported to be effective at reducing the risk , but concerns regarding the risks associated with this intervention remain.methods:systematic review and synthesis of the literatu...
[ "thyroid cancer is the most common endocrine neoplasia and accounts for 1% of all human cancers ( 1 ) . medullary thyroid carcinoma ( mtc ) is a rare neoplasm of the calcitonin - secreting thyroid cells and accounts for 510% of all thyroid cancers . mtc can occurs as sporadically ( 75% ) or as a part of the autosom...
abstractbackgroundmedullary thyroid carcinoma ( mtc ) occurs in both sporadic ( 75% ) and hereditary ( 25% ) forms . the missense mutations of the rearranged during transfection ( ret ) proto - oncogene in mtc development have been well demonstrated . the aim of this study was to investigate frequency of g691s / s904s ...
[ "after initial establishment and derivation of human embryonic stem cells ( hesc ; thomson et al . , 1998 ; reubinoff et al . , 2000 ) first the infection free status of the donors has to be addressed , in europe couples are tested before any fertility treatment is offered , but the cells themselves have to be test...
human embryonic stem cells ( hesc ) and induced pluripotent stem cells ( hipsc ) are an attractive cell source for regenerative medicine . these cells can be expanded to vast numbers and can be differentiated to many desired pluripotent stem cells ( psc ) derived therapeutic cells . cell replacement bears promises , bu...
[ "to report two cases of femtosecond laser - assisted small incision deep lamellar endothelial keratoplasty ( dlek ) for patients with corneal endothelial decompensation by fuchs dystrophy and glaucoma", "irvine , ca ) with 15 khz of repetition rate , was used for a 9.5 mm diameter by 400 m thickness donor corneal...
purposeto report two cases of femtosecond laser - assisted small incision deep lamellar endothelial keratoplasty ( dlek ) for patients with corneal endothelial decompensation by fuchs dystrophy and glaucomamethodsfemtosecond laser ( intralase ; intralase corp . , irvine , ca ) with 15 khz of repetition rate , was used ...
[ "the prevalence of diabetes has explosively increased worldwide , leading to an increase in the number of patients who suffer from diabetic vascular complications such as diabetic nephropathy ( dn ) . dn is not only the leading cause of end - stage kidney disease but also a significant risk factor for cardiovascula...
diabetic nephropathy ( dn ) is a leading cause of end - stage kidney disease ; however , there are few treatment options . inflammation plays a crucial role in the initiation and/or progression of dn . pituitary adenylate cyclase - activating polypeptide ( pacap ) is a neuropeptide , which was originally isolated from ...
[ "opsoclonus - myoclonus - ataxia syndrome ( omas ) , also called kinsbourne syndrome or dancing eye syndrome , is a serious , rare , and often chronic neurological disorder . omas consists of three main symptoms : opsoclonus ( conjugate , multidirectional , chaotic eye movements ) , myoclonus ( nonepileptic lim...
the opsoclonus - myoclonus ataxia syndrome ( omas ) also called kinsbourne syndrome or dancing eye syndrome is a rare but serious disorder characterized by opsoclonus , myoclonus , and ataxia , along with extreme irritability and behavioural changes . data on its epidemiology , clinical features , and outcome are l...
[ "to the surprise and deep disappointment of all involved in the treatment of lung cancer , several large trials did not demonstrate any benefit of tyrosine kinase inhibitors ( tkis ) as an addition to chemotherapy [ 13 ] . basic and clinical research then focused on mutations of the gene for epidermal growth factor...
background . intermittent application of chemotherapy and tyrosine kinase inhibitors may avoid antagonism between the two classes of drugs . this hypothesis was tested in a phase ii clinical trial . patients and methods . eligible patients were nonsmokers or light smokers , chemo - nave , with metastatic adenocarcino...
[ "using metagenomic deep sequencing , we analyzed fecal samples from 180 infants and children ages 7 days96 months ( mean 18.7 months ) in tunisia who had unexplained diarrhea that tested negative for rotavirus , norovirus , astrovirus , sapovirus , adenovirus types 40 and 41 , and aichi virus by reverse transcripti...
a divergent parvovirus genome was the only eukaryotic viral sequence detected in feces of a tunisian child with unexplained diarrhea . tusavirus 1 shared 44% and 39% identity with the nonstructural protein 1 and viral protein 1 , respectively , of the closest genome , kilham rat parvovirus , indicating presence of a ne...
[ "it may be regarded as the localized equivalent of the systemic inflammatory response seen after any trigger of inflammation , which recently has been described as systemic inflammatory response syndrome . the complex nature of surgical infections , the multifaceted aspects of treatment , and the complexity of inte...
introduction : peritonitis is one of the most common problems in general surgery practice with high mortality rate . one of the reasons for high mortality is that peritonitis affects the general condition and leads to complications causing multiple organ failure , renal failure , sepsis , and postoperative ventilatory ...
[ "during 20092010 , serum samples from patients with suspected dengue were received by the fdoh for dengue diagnostic testing ; the samples came from 16 of florida s 67counties . specific , real - time rt - pcr ( 8) and igm anti - denv elisa ( 9 ) . samples with highly positive rt - pcr results were spread onto cult...
sequencing of dengue virus type 1 ( denv-1 ) strains isolated in key west / monroe county , florida , indicate endemic transmission for > 2 years of a distinct and predominant sublineage of the american african genotype . denv-1 strains isolated elsewhere in florida grouped within a separate central american lineage ....
[ "corneal epithelium is able to alter its thickness to mask subepithelial stromal irregularities and maintain a smooth anterior surface of the eye . laser refractive surgery such as lasik alters the anterior corneal contour and leads to remodeling of corneal epithelium . we estimated the extent of the epithelial rem...
purpose . to quantify corneal epithelial thickness changes after myopic lasik by oct . methods . epithelial thickness before and after myopic lasik were measured by a fourier - domain oct system . average central ( within 1 mm diameter ) and paracentral epithelial thickness ( 5~6 mm diameter ) before and after lasi...
[ "this is particularly the case of the health of people living in contaminated site(s ) ( cs ) which is affected by the legacy of past industrialization and current industrial activities , often in absence of environmental remediation . european community legislation addresses the concept of cs only in the context o...
sentieri project ( epidemiological study of residents in italian contaminated sites ) studied mortality in the sites of national interest for environmental remediation ( national priority contaminated sites npcss ) . sentieri described mortality of residents in npcsss , and it specifically focused on causes of death f...
[ "the study population included 1177 patients who underwent different types of cardiac surgeries with cardiopulmonary bypass method at sina private hospital ( isfahan , iran ) , between april 2008 and september 2009 . all patients underwent a cardiovascular diagnostic procedure requiring the use of a contrast agent ...
background : there is limited data about the influence of timing of cardiac surgery in relation to diagnostic angiography and/or the impact of the amount of contrast media used during angiography on the occurance of acute renal failure ( arf ) . therefore , in the present study the effect of the time interval between d...
[ "colorectal cancer ( crc ) is one of the most common human malignancies in western countries . colorectal adenomas have high malignancy potential when they are large in diameter and/or present with severe dysplasia and/or a villous component . colonoscopic polypectomy has been documented to significantly reduce the...
predisposition to sporadic colorectal tumours is influenced by genes with minor phenotypic effects . a case - control study was set up on 295 patients treated for a large adenoma matched with polyp - free individuals on gender , age , and geographic origin in a 1 : 2 proportion . a second group of 302 patients treated ...
[ "a 56-year - old man suffering from diabetes and hypertension was admitted to the neurology department in a hospital elsewhere with signs of epileptic seizure . after a brief period , a diagnostic laparotomy with gastrotomy was performed , at which over 3 liters of blood were found , but no active bleeding . the si...
acute upper gastrointestinal tract hemorrhage represents a frequent morbidity which can be localized and treated endoscopically . when endoscopic treatment alone is failing , radiological or surgical treatment may be warranted . a case history will be presented regarding a rare cause of intestinal hemorrhage with an ex...
[ "today , implant therapy is regarded as an extremely reliable approach to replace missing teeth . the introduction of osseointegrated implants in dentistry represented a turning point in dental clinical practice.1 as a general principle in implant surgery implant surfaces should be surrounded by alveolar bone.2 fol...
background : decalcified freeze - dried bone allograft ( dfdba ) may have the potential to enhance bone formation around dental implants . our aim in this study was the evaluation and comparison of two types of dfdba in treatment of dehiscence defects around euroteknika implants in dogs.methods:in this prospective clin...
[ "the goal to achieve ideal pediatric drug therapy is a worldwide challenge for regulatory bodies and clinicians . children are treated with medicines not tested for safety and efficacy and are frequently supported by the low quality of evidence . in the absence of standard prescribing information , clinicians presc...
background . in the absence of standard pediatric prescribing information , clinicians often use medicines in an off - label way . many studies have been published across the globe reporting different rates of off - label use . there is currently no study based on indian drug formulary . methods . the prospective obs...
[ "the role of the thyroid gland in pregnancy and the impact of thyroid disorders on the course of pregnancy and development of the offspring have drawn a considerable interest in the recent years , both in the medical and in the general society . about 2 and 4% a growing body of evidence suggests that subclinical hy...
objective : to determine the importance of screening for thyriod disorders in the first trimester of pregnancy.materials and methods : the study was conducted on 305 patients which were were randomly selected and screened on opd basis by tsh levels ( cut off level 0.10 - 2.50 miu / ml).results : in the 305 women screen...
[ "esophageal cancer is a devastating disease with rapidly increasing incidence in western . despite important advances in therapy , > 50% of patients have incurable disease at diagnosis and only 510% of these patients have life expectancy > 5 years . dysphagia is the most common symptom that afflicts these patients ...
esophageal cancer is a devastating disease with rapidly increasing incidence in western countries . dysphagia is the most common complication , causing severe malnutrition and reduced quality of life . a 69-year - old male with persistent esophageal cancer after radiation therapy was subjected to palliative by - pass s...
[ "a 35-year - old female presented with a painless , slowly growing \n mass in the right inferior orbit for the past four years . she did \n not complain of diminution of visual acuity , diplopia or field \n defect . on examination , visual acuity in both eyes the right side demonstrated a solid , non - tender , \n ...
a rare case of unilateral orbital schwannoma arising from the infraorbital nerve is presented . an excision biopsy with complete removal of the mass in the inferior orbit was performed . a definitive diagnosis was made on histopathological examination . the clinical and histological features of schwannoma are ...
[ "risperidone has been reported to be effective in management of disruptive behaviors , including hyperactivity , irritability , aggression , and temper tantrums . increased appetite , weight gain , headache , and sedation literature search revealed only four published reports of risperidone - related bleeding , inc...
there are several case reports on risperidone - related bleeding ; however , to our knowledge , there is no report about gingival bleeding associated with risperidone in the literature . we presented a case who experienced gingival bleeding when risperidone dose was increased to 0.5 mg / day , and subsided after decrea...
[ "intestinal obstruction can be a result of mechanical or functional obstruction of the intestines , thereby preventing the normal transit of the products of digestion . intestinal pseudo - obstruction ( adynamic ) , characterized by abdominal pain , nausea , vomiting , constipation , and severe abdominal distension...
baclofen is a gamma- aminobutyric acid b ( gaba b ) agonist used for the management of spasticity associated with spinal cord injury . oral baclofen might cause constipation , but intestinal pseudo - obstruction is very rare . we report a 50-year - old male with spasticity following cervical discectomy ( c3 - 4 ) on or...
[ "the incidences were getting higher and higher . increased intramyocellular lipid accumulation plays a very important role in obesity and diabetes , as well as their complications [ 2 , 3 ] . this attracted great interest in the effect of accumulated lipid intermediates on insulin resistance [ 4 , 5 ] . lipotoxicit...
objective . by specific knockout of carnitine palmitoyl transferase 1b ( cpt1b ) in skeletal muscles , we explored the effect of cpt1b deficiency on lipids and insulin sensitivity . methods . mice with specific knockout of cpt1b in skeletal muscles ( cpt1b m/ ) were used for the experiment group , with littermate c57...
[ "pelvic organ prolapse ( pop ) is a major healthcare problem in middle - aged and elderly women and is usually accompanied by pelvic floor dysfunction ( pfd ) . the introduction of mesh repair in vaginal prolapse surgery showed possible advantageous results in early reports . however , pelvic floor structures progr...
background : mesh exposure after surgery continues to be a clinical challenge for urogynecological surgeons . the purpose of this study was to explore the risk factors for polypropylene ( pp ) mesh exposure after transvaginal mesh ( tvm ) surgery.methods:this study included 195 patients with advanced pelvic organ prola...
[ "5-fluorouracil ( 5-fu ) is a widely used chemotherapeutic drug and cardiac complications are not rare . however myocardial infarction , tako - tsubo - like syndrome and cardiogenic shock are also described .", "a 50-year - old man ( weight 70 kg , height 180 cm ) was admitted to a primary care hospital following...
a 50-year - old man with no previous history of cardiovascular disease or risk factors was admitted for syncope and orthopnea . importantly , he underwent recent chemotherapy with 5-fluorouracil ( 5-fu ) until 1 day before his acute presentation . in the emergency room , patient developed asystole and was successfully ...
[ "a summary of methods is provided below and a detailed description of methods is included in the supplementary information . the toxin nanosponges were prepared by fusing rbc membrane vesicles on preformed poly(lactic - co - glycolic acid ) ( plga ) nanoparticles through an established extrusion process . the size ...
detoxification treatments such as toxin - targeted anti - virulence therapy1 , 2 offer ways to cleanse the body of virulence factors that are caused by bacterial infections , venomous injuries , and biological weaponry . because existing detoxification platforms such as antisera3 , monoclonal antibodies4 , small - mole...
[ "hand , foot , and mouth disease ( hfmd ) is a common , acute , and mostly self - limiting enteroviral infection that presents with fever and vesicular lesions on the hands , feet , mouth , and frequently buttocks as characteristic features1,2,3,4 ) . although patients with hfmd recover without any sequelae within ...
hand , foot , and mouth disease ( hfmd ) is an acute , mostly self - limiting infection . patients usually recover without any sequelae . however , a few cases are life threatening , especially those caused by enterovirus 71 ( ev71 ) . a 12-month - old boy was admitted to a primary hospital with high fever and vesicula...
[ "since the increase in adiposity is related to general poor health factors such as an increase in type ii diabetes and increased incidence of coronary heart disease , exercise to reduce adiposity is recommended for the ageing population . a further consequence of the ageing process is that elderly individuals have ...
the present study was designed to investigate the effects of four different meals on fat and cho metabolism during subsequent exercise in elderly males . eight healthy males ( age : 63.3 5.2 years ) reported to the physiology laboratory on four separate occasions , each of which was allocated for the performance of a ...
[ "physical fitness is the ability that helps people to adapt with their environmental conditions and plays an important role in daily activities . it is highly associated to one 's health status and has a striking effect on the quality of life , learning and working efficiency , and physical activity contributions ....
background : physical exercises can influence some anthropometric and fitness components differently . the aim of present study was to evaluate how a relatively long - term training program in 11 - 14-year - old male iranian students affects their anthropometric and motor performance measures.methods:measurements were ...
[ "optical buffers are recognized as essential components in wavelength routers , in which the packets of data can be stored for resolving packet contention problems and also delay the outgoing packets.1,2 in practice , the optical router patents have been proposed and recorded,35 which can be useful for various appl...
a novel design of molecular buffer for molecule storage and delivery using a panda ring resonator is proposed . the optical vortices can be generated and controlled to form the trapping tools in the same way as the optical tweezers . in theory , the trapping force is formed by the combination between the gradient field...
[ "assessment of effects of different assisted reproductive techniques ( art ) like in vitro fertilization ( ivf ) and intra cytoplasmic sperm injection ( icsi ) on speech and language development needs comprehensive studies . some studies showed that they are more susceptible to cerebral palsy which causes speech an...
objectivethe aim of this study is assessment of effects of different assisted reproductive techniques ( art ) like in vitro fertilization ( ivf ) and intra cytoplasmic sperm injection ( icsi ) on prelinguistic behavior of infants conceived by these techniques.methodsin this descriptive , cross sectional study , preling...
[ "a number of drugs are currently available to treat malaria ; however , treatment is becoming complicated by drug resistance , toxicity , and high cost . recently , drug resistance against the new effective drug , artemisinin , is also emerging [ 4 , 5 ] , and we need new effective drugs to treat malaria . therefor...
evidence indicates that cysteine proteases play essential role in malaria parasites ; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria . studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemog...
[ "alzheimer 's disease ( ad ) is the most common cause of dementia in the aging population . this disease develops over time and leads to significant cognitive deficits affecting memory , insight , judgment , abstraction , and language functions . ad affects more than 5 million people in the united states and this n...
alzheimer 's disease ( ad ) is characterized by the presence of senile plaques and neurofibrillary tangles in the neocortex and hippocampus of ad patients . in addition , a marked decrease in synaptic contacts has been detected in these affected brain areas . due to its prevalence in the aging population , this disease...
[ "for many years , the global community has observed the calamitous effects of the human immunodeficiency virus ( hiv ) on the human population . hiv was historically viewed as an incurable disease that gradually progressed into acquired immune deficiency syndrome ( aids ) and led to one s untimely death . during hi...
background : hiv and aids continue to have a calamitous effect on individuals living on the continent of africa . u.s . president george w. bush implemented the president s emergency plan for aids relief ( pepfar ) with the objective of committing approximately $ 15 billion from 2004 through 2008 to assist with the red...
[ "descriptive investigation of a cluster of 5 sfts cases following exposure to an index patient who died from the disease was performed . a 77-year - old male farmer who died from sfts five other cases in the cluster included a 32-year - old male intensive care unit ( icu ) physician ( case 1 ) , a 48-year - old mal...
severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human . the transmission model has been largely uncharacterized . investigation on a cluster of severe fever with thrombocytopenia syndrome cases provided evidence of person - to - person transmission thro...
[ "therefore , the mother 's knowledge about child care influences the nature and quality of care that is given to the child . several studies have revealed that the mothers level of education has a positive impact on her knowledge and how she deals with child health care issues.[213 ] our experience in pediatric pra...
background : child care is mostly the responsibility of mothers . several studies have revealed that the mothers education has a positive impact on their knowledge and practice in child health matters.objectives:the study was undertaken to assess the level of mothers knowledge on certain aspects of child health care an...
[ "indications for covered self - expandable metallic airway stent removal include recurrent mucous plugging of the stent , excessive or recurrent granuloma formation , migration of the stent , stent infection , recurrence of stenosis , stent failure , stent fractures and accomplishment of treatment . usually , it is...
covered self expandable metallic airway stents ( sems ) have been used for benign tracheal stenosis , post intubation tracheal stenosis , tracheal burn or trauma , tracheo - broncho - malacia , and extrinsic compression of trachea . their placement is considered to be permanent , with open surgery the only way to remov...
[ "takayasu 's arteritis ( ta ) is a chronic idiopathic occlusive inflammation of aorta and its major branches predominantly affecting females in over 85% of cases . the major clinical finding is loss of palpable pulses in the upper limbs and neck . the unsuspected ischemia of vital regional vascular beds may render ...
hemorrhagic shock is the most common reason to explain the inability to feel pulse in a trauma patient . however , clinicians should always suspect atypical causes for differential pulses in this population and takayasu 's arteritis ( ta ) is one such example . we report a case of aorto - arteritis in a patient who pre...
[ "neurotransmitters ( nts ) are signaling molecules , which play pivotal roles in neuronal communications in the central nervous system [ 1 , 2 ] . it is reported that changes in nts quantitation in several brain regions involve the development of many psychiatric diseases and neurodegenerative diseases [ 3 , 4 ] . ...
a simple and rapid liquid chromatography tandem mass spectrometry method has been developed for the determination of bh4 , da , 5-ht , ne , ep , glu , and gaba in mouse brain using epsilon - acetamidocaproic acid and isotopically labeled neurotransmitters as internal standards . proteins in the samples were precipitate...
[ "it plays several important physiological and pathological roles in not only reproductive system but also other systems . estrogen disorder results in various diseases , such as endometrial diseases , skeletal diseases , and reproductive system tumors . increasing attention has been paid to revealing of the functio...
the g - protein - coupled estrogen receptor-1 ( gper-1 ) , also known as gpr30 , is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types . the progress of estrogen - related cancer is promoted by gper-1 activation through mitogen - activated protein kinases ( mapk ) , phosphoinositide ...
[ "ensemble hi - c protocol to create a method to determine the contacts in an individual nucleus ( fig . 1a , supplementary information ) . we used male , mouse , spleenic cd4 t cells , differentiated in vitro to t helper ( th1 ) cells to produce a population of cells ( > 95% cd4 ) , of which 69% have 2n genome con...
large - scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and dna replication and repair . genomic techniques based on chromosome conformation capture assess contacts for millions of loci simultaneously , but do so by averaging chromosome conformations from millio...
[ "oligonucleotides were synthesized on an expedite automated dna / rna synthesizer ( applied biosystems , foster city , ca ) using nucleoside phosphoramidites purchased from glen research ( sterling , va ) . all oligonucleotides were purified by denaturing polyacrylamide gel electrophoresis ( page ) and desalted usi...
rna enzymes have been developed that undergo self - sustained replication at a constant temperature in the absence of proteins1 . these rna molecules amplify exponentially through a cross - replicative process , whereby two enzymes catalyze each other s synthesis by joining component oligonucleotides . other rna enzyme...
[ "neoadjuvant chemotherapy actually takes an important place in treatment of operable breast cancer in the hope of improving conservative surgery rate of female patients . neoadjuvant chemotherapy includes today on target therapies involving the research on expression of specific molecules by tumoral cells . in rout...
despite the fact that cnb has been progressively replaced by fnac in the investigation of nonpalpable lesions or microcalcifications without a clinical or radiological mass lesion , fnac has yet a role in palpable lesions provided it is associated with the triple diagnosis and experienced cytologist . in these conditio...
[ "understanding how and why vector - borne diseases like malaria remain a persistent problem despite being tools for diagnosis and treatment is essential for developing effective control measures for sub - saharan africa . temperature is one of the key climatic variables that determine the range of malaria transmiss...
this study investigated potential risk factors associated with malaria transmission in tubu village , okavango subdistrict , a malaria endemic area in northern botswana . data was derived from a census questionnaire survey , participatory rural appraisal workshop , field observations , and mosquito surveys . history ...
[ "the prevalence of pancreatic cystic neoplasms ( pcns ) is around 2.5%.1,2 pancreatic cysts are increasingly discovered probably because of the ubiquitous presence of multi - detector computed tomography ( ct ) scans and their increased use to evaluate patients with abdominal complaints . endoscopic ultrasound ( eu...
incidental pancreatic cysts are being increasingly recognized recently with incremented concern about health and frequent health check - up . endoscopic ultrasound ( eus ) has emerged as the principal modality for imaging pancreas for various pancreatic diseases including pancreatic cyst . but imaging alone can not acc...
[ "brucellosis is a zoonotic disease mostly transmitted to humans through consumption of unpasteurized dairy products and can lead to a systemic disease with any organ involvement . in this report , we describe a case of brucellosis - induced avascular necrosis of the hip . brucellosis was diagnosed through serologic...
backgroundbrucellosis is a zoonotic disease mostly transmitted to humans through consumption of unpasteurized dairy products and can lead to a systemic disease with any organ involvement . in this report , we describe a case of brucellosis - induced avascular necrosis of the hip . brucellosis was diagnosed through sero...
[ "since the framingham heart study first reported risk factors for atherosclerotic cardiovascular disease , numerous efforts have aimed at improving risk assessment in the asymptomatic population . over time , these efforts have resulted in the introduction of framingham risk score ( frs ) and other biomarkers inc...
background . endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity . several studies showed digital thermal monitoring ( dtm ) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronar...
[ "a sandwich or laminate technique is one of the methods proposed for composite resin restorations , which was introduced for the first time by mclean , et al . in 1985 . the basic idea behind this technique is to use two different restorative materials for a single restorative procedure so that the maximum physico ...
background : an appropriate bond between glass - ionomer and the superficial resin materials is very important for the success of sandwich technique . the aim of the present in vitro study was to evaluate the effect of three surface treatments of conventional glass - ionomer on its shear bond strength to giomer.materia...
[ "planning , evaluating , and budget allocation for prevention programs are contingent upon estimating the size of their target groups . population size estimation of the target groups in some context , such as hiv / aids , always entail numerous challenges in countries where such diseases are concentrated in specif...
abstractbackgroundnetwork scale - up is an indirect method for estimating the size of hidden , hard - to - count or high risk populations . social network size estimation is the first step in this method . the present study was conducted with the purpose of estimating the social network size of the tehran province resi...
[ "", "benign prostatic hyperplasia ( bph ) is a highly prevalent disease affecting middle aged and elderly men ( 1 ) . in the united states , bph is the most common benign tumor in men and is the most typically the disorder that reduces the quality of life ( qol ) in men , causing lower urinary tract symptoms ( lu...
using the korean public health insurance database , we analyzed patients diagnosed as benign prostatic hyperplasia ( bph ) from 2004 to 2008 . age and year - specific amount and seasonal variation of hospital visits ( hv ) , duration of treatment ( dt ) , the total and per capita amount of insurance payment ( taip , pc...
[ "primary retroperitoneal tumors ( prts ) of vascular origin are a diverse group of rare abdominal neoplasms , both benign and malignant . the most frequent malignant tumors are liposarcoma and leiomyosarcoma , while the most often found benign tumors are lipoma , leiomyoma and cavernous hemangioma [ 25 ] . hemangio...
retroperitoneal hemangiomas are very rare . this paper presents the case of a 71-year - old female patient with giant cavernous hemangioma of the retroperitoneum who underwent surgical treatment for abdominal pain and left lower limb edema . interventional staged treatment with percutaneous transcatheter arterial embol...
[ "the pathogenesis of gmd in pd patients is related to factors such as weight gain and insulin resistance evoked by peritoneal glucose load [ 13 ] . the periodical evaluation of pd patients for gmd is of clinical relevance and should be an element of the surveillance protocol . the gold standard method used for th...
background the aim was to evaluate the clinical utility of the oral glucose tolerance screening test ( 50-g gct glucose challenge test ) for the detection of glucose metabolism disorders ( gmd ) in peritoneal dialysis ( pd ) patients with normal fasting glucose levels . methods the 50-g gct was performed in 20 p...
[ "proteomics has emerged as a valuable tool \n for the identification \n of biomarkers associated with human disease including those resulting from very subtle changes in normal cell \n functions and signaling pathways . proteomic technology has advanced \n to a state where thousands of proteins can be identified wi...
formaldehyde - fixed , paraffin - embedded ( ffpe ) tissue repositories represent a valuable resource for the retrospective study of disease progression and response to therapy . however , the proteomic analysis of ffpe tissues has been hampered by formaldehyde - induced protein modifications , which reduce pro...
[ "type 2 diabetes mellitus ( t2 dm ) is considered a major epidemic of this century . it is estimated that its prevalence will increase worldwide from 371 million people in 2013 to 552 million people in 2030 . t2 dm is associated with accelerated progression of atherosclerosis , the major cause of vascular complicat...
background . the current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor ( vegf ) gene ( rs2010963 ) and its receptor , kinase insert domain - containing receptor ( kdr ) gene polymorphism ( rs2071559 ) , and markers of carotid atherosclerosis in ...
[ "hidradenomas are benign cutaneous tumors of sweat gland origin , with the clear cell type constituting the most frequent histologic variety . usually , they are diagnosed in the elderly population , the peak incidence being the fifth to sixth decade . we describe a young girl , in whom nodular hidradenoma develope...
a 10-year - old girl presented with a swelling on her left thigh that was associated with dripping of serous fluid from the lesion . based on histological features of the excised tumor , a diagnosis of nodular hidradenoma was made . atypical features including large size of the tumor , location on the lower limb , a we...
[ "the gothenburg osteoporosis and obesity determinants ( good ) study was initiated with the aim to determine both environmental and genetic factors involved in the regulation of fat mass as previously described ( 23 ) . to be included in the good study , subjects had to be male , 18 to 20 years of age , and willing...
objectivethe amount of visceral adipose tissue is a risk factor for the metabolic syndrome . it is unclear how bmi changes during childhood and adolescence predict adult fat distribution . we hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass b...
[ "it is estimated that around 50% of the population has one or more sites with 1 mm or more of such root exposure . this prevalence rate increases to > 88% in individuals who are 65 years or older . key factors in the treatment of gingival recession are to prevent the progressive marginal tissue recession and to fac...
background : the purpose of this study was to assess the efficacy of hyaluronic acid ( ha ) in root coverage procedures as an adjunct to coronally advanced flap ( caf ) procedure.materials and methods : this was a randomized clinical trial with split mouth design , where 10 patients with 20 sites of millers class i rec...
[ "ulcerative colitis ( uc ) is characterized by chronic and relapsing inflammation of the intestines , resulting in diarrhea , abdominal pain , and a variety of other symptoms ( 1 ) , and impacts negatively on the quality of life . huangqing - tang decoction , described by zhang zhongjing ( 150 to 219 a.d . , in chi...
the aim of this study was to investigate the pharmacokinetic profiles of baicalin , wogonoside , baicalein and wogonin after oral administration of pure baicalin , radix scutellariae and scutellariae - paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerati...
[ "weekly creatinine clearance ( wccr ) and kt / v are well - known parameters reflecting dialysis \n dose and adequacy , and are applied to adjustment of the dialysis menu in each patient who \n undergoes peritoneal dialysis ( pd ) . however , the limitations of these parameters in \n predicting survival and morbidi...
objective : the usefulness of estimated glomerular filtration rate may not be restricted to pre - dialysis patients , since we reported that estimated glomerular filtration rate was well correlated with measured total creatinine clearance in peritoneal dialysis patients . to clarify the clinical usefulness of est...
[ "mesenchymal stem cells ( mscs ) , also referred to as multipotent mesenchymal stromal cells , have been a focus of recent research , partially because they are an extraordinary model for investigating the biological mechanisms that allow a cellular population to generate diverse cell types and because they are a p...
mesenchymal stem cells ( mscs ) are multipotent cells capable of differentiation into mesenchymal lineages and that can be isolated from various tissues and easily cultivated in vitro . currently , mscs are of considerable interest because of the biological characteristics that confer high potential applicability in th...
[ "carpal instability is broad category consisting of various patterns of injury , with dissociative type more common .", "a 13 -year -old boy presented at 6 months following a fall with restriction of wrist movements . patient had sustained a closed distal one -third both bones fracture forearm fixed with k -wire ...
introduction : carpal instability is broad category consisting of various patterns of injury , with dissociative type more common.case report : a 13 -year -old boy presented at 6 months following a fall with restriction of wrist movements . patient had sustained a closed distal one -third both bones fracture forearm fi...
[ "\n preeclampsia is a disorder affecting 5 to 10% of pregnancies and is clinically characterized by new - onset hypertension and proteinuria . despite significant progress in our understanding of preeclampsia , there is a need for a reliable diagnostic biomarker for use in clinical practice . in the search for a bi...
urinary podocyte ( podocyturia ) has been studied as a diagnostic marker for preeclampsia . we sought to validate its use in preeclampsia and in differentiating it from other high risk pregnancy states . we studied an obstetric population at high risk to develop preeclampsia ( study group ) and uncomplicated pregnanc...
[ "illness is a challenge to our physical , psychological and spiritual wellbeing that has repercussions on our identity and our social context . in a pathogenetic approach , diagnostic tests are used to look for the underlying disease and treatments are aimed at removing it . a person is considered cured when the di...
the purpose of this review is to discuss how a salutogenetic approach that takes into consideration the human being as physical , psychological and spiritual entity may provide some answers to the difficulties faced by healthcare systems . the choice of medical intervention needs to take into account the technological ...
[ "macroautophagy ( abbreviated as autophagy ) is a genetically regulated and evolutionarily conserved pathway for the degradation of subcellular components [ 15 ] . this process involves the de novo formation of cytoplasmic double membrane - bound vacuoles termed autophagosomes , which sequester cytosolic cargo fo...
autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins , through a lysosome - dependent degradation pathway . during starvation , autophagy facilitates cell survival through the recycling of metabolic precursors . additionally , autophagy can modulate other vital processes suc...
[ "koreich in 1981 first reported the case of a 22 year old man diagnosed as hodgkin lymphoma ( hl ) who developed hypothermia and hypotension during the course of his admission , which resolved only after initiation of chemotherapy . systemic symptoms are present in a third of patients at presentation and among them...
hypotension is an extremely rare manifestation of hodgkin lymphoma . we report the case of a patient who presented with new onset hypotension and was diagnosed with urosepsis and septic shock requiring pressor support for maintaining his blood pressure . computed tomography ( ct ) scan of abdomen showed liver lesions ,...