accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q8TDN7 | ACER1_HUMAN | N-acylsphingosine amidohydrolase 3 | Homo | <M><P><S><I><F><A><Y><Q><S><S><E><V><D><W><C><E><S><N><F><Q><Y><S><E><L><V><A><E><F><Y><N><T><F><S><N><I><P><F><F><I><F><G><P><L><M><M><L><L><M><H><P><Y><A><Q><K><R><S><R><Y><I><Y><V><V><W><V><L><F><M><I><I><G><L><F><S><M><Y><F><H><M><T><L><S><F><L><G><Q><L><L><D><E><I><A><I><L><W><L><L><G><S><G><Y><S><I><W><M><P><R><C><Y><F><P><S><F><L><G><G><N><R><S><Q><F><I><R><L><V><F><I><T><T><V><V><S><T><L><L><S><F><L><R><P><T><V><N><A><Y><A><L><N><S><I><A><L><H><I><L><Y><I><V><C><Q><E><Y><R><K><T><S><N><K><E><L><R><H><L><I><E><V><S><V><V><L><W><A><V><A><L><T><S><W><I><S><D><R><L><L><C><S><F><W><Q><R><I><H><F><F><Y><L><H><S><I><W><H><V><L><I><S><I><T><F><P><Y><G><M><V><T><M><A><L><V><D><A><N><Y><E><M><P><G><E><T><L><K><V><R><Y><W><P><R><D><S><W><P><V><G><L><P><Y><V><E><I><R><G><D><D><K><D><C> | Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide . May also hydrolyze dihydroceramides to produce dihydrosphingosine . ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis .<BOP> | Q8TDN7 |
Q5XLA6 | CAR17_HUMAN | Inhibitory caspase recruitment domain protein | Homo | <M><A><D><K><V><L><K><E><K><R><K><Q><F><I><R><S><V><G><E><G><T><I><N><G><L><L><G><E><L><L><E><T><R><V><L><S><Q><E><E><I><E><I><V><K><C><E><N><A><T><V><M><D><K><A><R><A><L><L><D><S><V><I><R><K><G><A><P><A><C><Q><I><C><I><T><Y><I><C><E><E><D><S><H><L><A><G><T><L><G><L><S><A><G><P><T><S><G><N><H><L><T><T><Q><D><S><Q><I><V><L><P><S> | Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.<BOP> | Q5XLA6 |
Q6NXS1 | IPP2B_HUMAN | Protein phosphatase inhibitor 2-like protein 3 | Homo | <M><A><A><S><T><A><S><H><R><P><I><K><G><I><L><K><N><K><T><S><T><T><S><S><M><V><A><S><A><E><Q><P><R><R><S><V><D><E><E><L><S><K><K><S><Q><K><W><D><E><I><N><I><L><A><T><Y><H><P><A><D><K><G><Y><G><L><M><K><I><D><E><P><S><P><P><Y><H><S><M><M><G><D><D><E><D><A><C><R><D><T><E><T><T><E><A><M><A><P><D><I><L><A><K><K><L><A><A><A><E><G><L><E><P><K><Y><R><I><Q><E><Q><E><S><S><G><E><E><D><S><D><L><S><P><E><E><R><E><K><K><R><Q><F><E><M><R><R><K><L><H><Y><N><E><G><L><N><I><K><L><A><R><Q><L><I><S><K><D><L><H><D><D><D><E><D><E><E><M><L><E><T><A><D><G><E><S><M><N><T><E><E><S><N><Q><G><S><T><P><S><D><Q><Q><Q><N><K><L><R><S><S> | Inhibitor of protein-phosphatase 1.<BOP> | Q6NXS1 |
Q13630 | FCL_HUMAN | Short-chain dehydrogenase/reductase family 4E member 1 | Homo | <M><G><E><P><Q><G><S><M><R><I><L><V><T><G><G><S><G><L><V><G><K><A><I><Q><K><V><V><A><D><G><A><G><L><P><G><E><D><W><V><F><V><S><S><K><D><A><D><L><T><D><T><A><Q><T><R><A><L><F><E><K><V><Q><P><T><H><V><I><H><L><A><A><M><V><G><G><L><F><R><N><I><K><Y><N><L><D><F><W><R><K><N><V><H><M><N><D><N><V><L><H><S><A><F><E><V><G><A><R><K><V><V><S><C><L><S><T><C><I><F><P><D><K><T><T><Y><P><I><D><E><T><M><I><H><N><G><P><P><H><N><S><N><F><G><Y><S><Y><A><K><R><M><I><D><V><Q><N><R><A><Y><F><Q><Q><Y><G><C><T><F><T><A><V><I><P><T><N><V><F><G><P><H><D><N><F><N><I><E><D><G><H><V><L><P><G><L><I><H><K><V><H><L><A><K><S><S><G><S><A><L><T><V><W><G><T><G><N><P><R><R><Q><F><I><Y><S><L><D><L><A><Q><L><F><I><W><V><L><R><E><Y><N><E><V><E><P><I><I><L><S><V><G><E><E><D><E><V><S><I><K><E><A><A><E><A><V><V><E><A><M><D><F><H><G><E><V><T><F><D><T><T><K><S><D><G><Q><F><K><K><T><A><S><N><S><K><L><R><T><Y><L><P><D><F><R><F><T><P><F><K><Q><A><V><K><E><T><C><A><W><F><T><D><N><Y><E><Q><A><R><K> | Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.<BOP> | Q13630 |
P00156 | CYB_HUMAN | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit | Homo | <M><T><P><M><R><K><T><N><P><L><M><K><L><I><N><H><S><F><I><D><L><P><T><P><S><N><I><S><A><W><W><N><F><G><S><L><L><G><A><C><L><I><L><Q><I><T><T><G><L><F><L><A><M><H><Y><S><P><D><A><S><T><A><F><S><S><I><A><H><I><T><R><D><V><N><Y><G><W><I><I><R><Y><L><H><A><N><G><A><S><M><F><F><I><C><L><F><L><H><I><G><R><G><L><Y><Y><G><S><F><L><Y><S><E><T><W><N><I><G><I><I><L><L><L><A><T><M><A><T><A><F><M><G><Y><V><L><P><W><G><Q><M><S><F><W><G><A><T><V><I><T><N><L><L><S><A><I><P><Y><I><G><T><D><L><V><Q><W><I><W><G><G><Y><S><V><D><S><P><T><L><T><R><F><F><T><F><H><F><I><L><P><F><I><I><A><A><L><A><T><L><H><L><L><F><L><H><E><T><G><S><N><N><P><L><G><I><T><S><H><S><D><K><I><T><F><H><P><Y><Y><T><I><K><D><A><L><G><L><L><L><F><L><L><S><L><M><T><L><T><L><F><S><P><D><L><L><G><D><P><D><N><Y><T><L><A><N><P><L><N><T><P><P><H><I><K><P><E><W><Y><F><L><F><A><Y><T><I><L><R><S><V><P><N><K><L><G><G><V><L><A><L><L><L><S><I><L><I><L><A><M><I><P><I><L><H><M><S><K><Q><Q><S><M><M><F><R><P><L><S><Q><S><L><Y><W><L><L><A><A><D><L><L><I><L><T><W><I><G><G><Q><P><V><S><Y><P><F><T><I><I><G><Q><V><A><S><V><L><Y><F><T><T><I><L><I><L><M><P><T><I><S><L><I><E><N><K><M><L><K><W><A> | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.<BOP> | P00156 |
Q9NYP9 | MS18A_HUMAN | FAPP1-associated protein 1 | Homo | <M><A><G><V><R><S><L><R><C><S><R><G><C><A><G><G><C><E><C><G><D><K><G><K><C><S><D><S><S><L><L><G><K><R><L><S><E><D><S><S><R><H><Q><L><L><Q><K><W><A><S><M><W><S><S><M><S><E><D><A><S><V><A><D><M><E><R><A><Q><L><E><E><E><A><A><A><A><E><E><R><P><L><V><F><L><C><S><G><C><R><R><P><L><G><D><S><L><S><W><V><A><S><Q><E><D><T><N><C><I><L><L><R><C><V><S><C><N><V><S><V><D><K><E><Q><K><L><S><K><R><E><K><E><N><G><C><V><L><E><T><L><C><C><A><G><C><S><L><N><L><G><Y><V><Y><R><C><T><P><K><N><L><D><Y><K><R><D><L><F><C><L><S><V><E><A><I><E><S><Y><V><L><G><S><S><E><K><Q><I><V><S><E><D><K><E><L><F><N><L><E><S><R><V><E><I><E><K><S><L><T><Q><M><E><D><V><L><K><A><L><Q><M><K><L><W><E><A><E><S><K><L><S><F><A><T><C><K><S> | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.<BOP> | Q9NYP9 |
Q8NGV7 | OR5H2_HUMAN | Olfactory receptor OR3-10 | Homo | <M><S><N><E><D><M><E><Q><D><N><T><T><L><L><T><E><F><V><L><T><G><L><T><Y><Q><P><E><W><K><M><P><L><F><L><V><F><L><V><I><Y><L><I><T><I><V><W><N><L><G><L><I><A><L><I><W><N><D><P><Q><L><H><I><P><M><Y><F><F><L><G><S><L><A><F><V><D><A><W><I><S><S><T><V><T><P><K><M><L><V><N><F><L><A><K><N><R><M><I><S><L><S><E><C><M><I><Q><F><F><S><F><A><F><G><G><T><T><E><C><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><K><P><L><L><Y><P><V><I><M><N><N><S><L><C><I><R><L><L><A><F><S><F><L><G><G><F><L><H><A><L><I><H><E><V><L><I><F><R><L><T><F><C><N><S><N><I><I><H><H><F><Y><C><D><I><I><P><L><F><M><I><S><C><T><D><P><S><I><N><F><L><M><V><F><I><L><S><G><S><I><Q><V><F><T><I><V><T><V><L><N><S><Y><T><F><A><L><F><T><I><L><K><K><K><S><V><R><G><V><R><K><A><F><S><T><C><G><A><H><L><L><S><V><S><L><Y><Y><G><P><L><I><F><M><Y><L><R><P><A><S><P><Q><A><D><D><Q><D><M><I><D><S><V><F><Y><T><I><I><I><P><L><L><N><P><I><I><Y><S><L><R><N><K><Q><V><I><D><S><F><T><K><M><V><K><R><N><V> | Odorant receptor.<BOP> | Q8NGV7 |
O75084 | FZD7_HUMAN | FzE3 | Homo | <M><R><D><P><G><A><A><A><P><L><S><S><L><G><L><C><A><L><V><L><A><L><L><G><A><L><S><A><G><A><G><A><Q><P><Y><H><G><E><K><G><I><S><V><P><D><H><G><F><C><Q><P><I><S><I><P><L><C><T><D><I><A><Y><N><Q><T><I><L><P><N><L><L><G><H><T><N><Q><E><D><A><G><L><E><V><H><Q><F><Y><P><L><V><K><V><Q><C><S><P><E><L><R><F><F><L><C><S><M><Y><A><P><V><C><T><V><L><D><Q><A><I><P><P><C><R><S><L><C><E><R><A><R><Q><G><C><E><A><L><M><N><K><F><G><F><Q><W><P><E><R><L><R><C><E><N><F><P><V><H><G><A><G><E><I><C><V><G><Q><N><T><S><D><G><S><G><G><P><G><G><G><P><T><A><Y><P><T><A><P><Y><L><P><D><L><P><F><T><A><L><P><P><G><A><S><D><G><R><G><R><P><A><F><P><F><S><C><P><R><Q><L><K><V><P><P><Y><L><G><Y><R><F><L><G><E><R><D><C><G><A><P><C><E><P><G><R><A><N><G><L><M><Y><F><K><E><E><E><R><R><F><A><R><L><W><V><G><V><W><S><V><L><C><C><A><S><T><L><F><T><V><L><T><Y><L><V><D><M><R><R><F><S><Y><P><E><R><P><I><I><F><L><S><G><C><Y><F><M><V><A><V><A><H><V><A><G><F><L><L><E><D><R><A><V><C><V><E><R><F><S><D><D><G><Y><R><T><V><A><Q><G><T><K><K><E><G><C><T><I><L><F><M><V><L><Y><F><F><G><M><A><S><S><I><W><W><V><I><L><S><L><T><W><F><L><A><A><G><M><K><W><G><H><E><A><I><E><A><N><S><Q><Y><F><H><L><A><A><W><A><V><P><A><V><K><T><I><T><I><L><A><M><G><Q><V><D><G><D><L><L><S><G><V><C><Y><V><G><L><S><S><V><D><A><L><R><G><F><V><L><A><P><L><F><V><Y><L><F><I><G><T><S><F><L><L><A><G><F><V><S><L><F><R><I><R><T><I><M><K><H><D><G><T><K><T><E><K><L><E><K><L><M><V><R><I><G><V><F><S><V><L><Y><T><V><P><A><T><I><V><L><A><C><Y><F><Y><E><Q><A><F><R><E><H><W><E><R><T><W><L><L><Q><T><C><K><S><Y><A><V><P><C><P><P><G><H><F><P><P><M><S><P><D><F><T><V><F><M><I><K><Y><L><M><T><M><I><V><G><I><T><T><G><F><W><I><W><S><G><K><T><L><Q><S><W><R><R><F><Y><H><R><L><S><H><S><S><K><G><E><T><A><V> | (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.<BOP> | O75084 |
Q9Y3C0 | WASC3_HUMAN | Coiled-coil domain-containing protein 53 | Homo | <M><D><E><D><G><L><P><L><M><G><S><G><I><D><L><T><K><V><P><A><I><Q><Q><K><R><T><V><A><F><L><N><Q><F><V><V><H><T><V><Q><F><L><N><R><F><S><T><V><C><E><E><K><L><A><D><L><S><L><R><I><Q><Q><I><E><T><T><L><N><I><L><D><A><K><L><S><S><I><P><G><L><D><D><V><T><V><E><V><S><P><L><N><V><T><S><V><T><N><G><A><H><P><E><A><T><S><E><Q><P><Q><Q><N><S><T><Q><D><S><G><L><Q><E><S><E><V><S><A><E><N><I><L><T><V><A><K><D><P><R><Y><A><R><Y><L><K><M><V><Q><V><G><V><P><V><M><A><I><R><N><K><M><I><S><E><G><L><D><P><D><L><L><E><R><P><D><A><P><V><P><D><G><E><S><E><K><T><V><E><E><S><S><D><S><E><S><S><F><S><D> | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.<BOP> | Q9Y3C0 |
Q9H7T9 | AUNIP_HUMAN | Aurora kinase A and ninein-interacting protein | Homo | <M><R><R><T><G><P><E><E><E><A><C><G><V><W><L><D><A><A><A><L><K><R><R><K><V><Q><T><H><L><I><K><P><G><T><K><M><L><T><L><L><P><G><E><R><K><A><N><I><Y><F><T><Q><R><R><A><P><S><T><G><I><H><Q><R><S><I><A><S><F><F><T><L><Q><P><G><K><T><N><G><S><D><Q><K><S><V><S><S><H><T><E><S><Q><I><N><K><E><S><K><K><N><A><T><Q><L><D><H><L><I><P><G><L><A><H><D><C><M><A><S><P><L><A><T><S><T><T><A><D><I><Q><E><A><G><L><S><P><Q><S><L><Q><T><S><G><H><H><R><M><K><T><P><F><S><T><E><L><S><L><L><Q><P><D><T><P><D><C><A><G><D><S><H><T><P><L><A><F><S><F><T><E><D><L><E><S><S><C><L><L><D><R><K><E><E><K><G><D><S><A><R><K><W><E><W><L><H><E><S><K><K><N><Y><Q><S><M><E><K><H><T><K><L><P><G><D><K><C><C><Q><P><L><G><K><T><K><L><E><R><K><V><S><A><K><E><N><R><Q><A><P><V><L><L><Q><T><Y><R><E><S><W><N><G><E><N><I><E><S><V><K><Q><S><R><S><P><V><S><V><F><S><W><D><N><E><K><N><D><K><D><S><W><S><Q><L><F><T><E><D><S><Q><G><Q><R><V><I><A><H><N><T><R><A><P><F><Q><D><V><T><N><N><W><N><W><D><L><G><P><F><P><N><S><P><W><A><Q><C><Q><E><D><G><P><T><Q><N><L><K><P><D><L><L><F><T><Q><D><S><E><G><N><Q><V><I><R><H><Q><F> | DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination . Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair . Inhibits non-homologous end joining (NHEJ) . Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle .<BOP> | Q9H7T9 |
Q6UW49 | SPESP_HUMAN | Glycosylated 38 kDa sperm protein C-7/8 | Homo | <M><K><P><L><V><L><L><V><A><L><L><L><W><P><S><S><V><P><A><Y><P><S><I><T><V><T><P><D><E><E><Q><N><L><N><H><Y><I><Q><V><L><E><N><L><V><R><S><V><P><S><G><E><P><G><R><E><K><K><S><N><S><P><K><H><V><Y><S><I><A><S><K><G><S><K><F><K><E><L><V><T><H><G><D><A><S><T><E><N><D><V><L><T><N><P><I><S><E><E><T><T><T><F><P><T><G><G><F><T><P><E><I><G><K><K><K><H><T><E><S><T><P><F><W><S><I><K><P><N><N><V><S><I><V><L><H><A><E><E><P><Y><I><E><N><E><E><P><E><P><E><P><E><P><A><A><K><Q><T><E><A><P><R><M><L><P><V><V><T><E><S><S><T><S><P><Y><V><T><S><Y><K><S><P><V><T><T><L><D><K><S><T><G><I><G><I><S><T><E><S><E><D><V><P><Q><L><S><G><E><T><A><I><E><K><P><E><E><F><G><K><H><P><E><S><W><N><N><D><D><I><L><K><K><I><L><D><I><N><S><Q><V><Q><Q><A><L><L><S><D><T><S><N><P><A><Y><R><E><D><I><E><A><S><K><D><H><L><K><R><S><L><A><L><A><A><A><A><E><H><K><L><K><T><M><Y><K><S><Q><L><L><P><V><G><R><T><S><N><K><I><D><D><I><E><T><V><I><N><M><L><C><N><S><R><S><K><L><Y><E><Y><L><D><I><K><C><V><P><P><E><M><R><E><K><A><A><T><V><F><N><T><L><K><N><M><C><R><S><R><R><V><T><A><L><L><K><V><Y> | Involved in fertilization ability of sperm.<BOP> | Q6UW49 |
Q8WXI4 | ACO11_HUMAN | Palmitoyl-coenzyme A thioesterase | Homo | <M><I><Q><N><V><G><N><H><L><R><R><G><L><A><S><V><F><S><N><R><T><S><R><K><S><A><L><R><A><G><N><D><S><A><M><A><D><G><E><G><Y><R><N><P><T><E><V><Q><M><S><Q><L><V><L><P><C><H><T><N><Q><R><G><E><L><S><V><G><Q><L><L><K><W><I><D><T><T><A><C><L><S><A><E><R><H><A><G><C><P><C><V><T><A><S><M><D><D><I><Y><F><E><H><T><I><S><V><G><Q><V><V><N><I><K><A><K><V><N><R><A><F><N><S><S><M><E><V><G><I><Q><V><A><S><E><D><L><C><S><E><K><Q><W><N><V><C><K><A><L><A><T><F><V><A><R><R><E><I><T><K><V><K><L><K><Q><I><T><P><R><T><E><E><E><K><M><E><H><S><V><A><A><E><R><R><R><M><R><L><V><Y><A><D><T><I><K><D><L><L><A><N><C><A><I><Q><G><D><L><E><S><R><D><C><S><R><M><V><P><A><E><K><T><R><V><E><S><V><E><L><V><L><P><P><H><A><N><H><Q><G><N><T><F><G><G><Q><I><M><A><W><M><E><N><V><A><T><I><A><A><S><R><L><C><R><A><H><P><T><L><K><A><I><E><M><F><H><F><R><G><P><S><Q><V><G><D><R><L><V><L><K><A><I><V><N><N><A><F><K><H><S><M><E><V><G><V><C><V><E><A><Y><R><Q><E><A><E><T><H><R><R><H><I><N><S><A><F><M><T><F><V><V><L><D><A><D><D><Q><P><Q><L><L><P><W><I><R><P><Q><P><G><D><G><E><R><R><Y><R><E><A><S><A><R><K><K><I><R><L><D><R><K><Y><I><V><S><C><K><Q><T><E><V><P><L><S><V><P><W><D><P><S><N><Q><V><Y><L><S><Y><N><N><V><S><S><L><K><M><L><V><A><K><D><N><W><V><L><S><S><E><I><S><Q><V><R><L><Y><T><L><E><D><D><K><F><L><S><F><H><M><E><M><V><V><H><V><D><A><A><Q><A><F><L><L><L><S><D><L><R><Q><R><P><E><W><D><K><H><Y><R><S><V><E><L><V><Q><Q><V><D><E><D><D><A><I><Y><H><V><T><S><P><A><L><G><G><H><T><K><P><Q><D><F><V><I><L><A><S><R><R><K><P><C><D><N><G><D><P><Y><V><I><A><L><R><S><V><T><L><P><T><H><R><E><T><P><E><Y><R><R><G><E><T><L><C><S><G><F><C><L><W><R><E><G><D><Q><L><T><K><C><C><W><V><R><V><S><L><T><E><L><V><S><A><S><G><F><Y><S><W><G><L><E><S><R><S><K><G><R><R><S><D><G><W><N><G><K><L><A><G><G><H><L><S><T><L><K><A><I><P><V><A><K><I><N><S><R><F><G><Y><L><Q><D><T> | Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway.<BOP> | Q8WXI4 |
Q8N5I4 | DHRSX_HUMAN | Short chain dehydrogenase/reductase family 7C member 6 | Homo | <M><S><P><L><S><A><A><R><A><A><L><R><V><Y><A><V><G><A><A><V><I><L><A><Q><L><L><R><R><C><R><G><G><F><L><E><P><V><F><P><P><R><P><D><R><V><A><I><V><T><G><G><T><D><G><I><G><Y><S><T><A><K><H><L><A><R><L><G><M><H><V><I><I><A><G><N><N><D><S><K><A><K><Q><V><V><S><K><I><K><E><E><T><L><N><D><K><V><E><F><L><Y><C><D><L><A><S><M><T><S><I><R><Q><F><V><Q><K><F><K><M><K><K><I><P><L><H><V><L><I><N><N><A><G><V><M><M><V><P><Q><R><K><T><R><D><G><F><E><E><H><F><G><L><N><Y><L><G><H><F><L><L><T><N><L><L><L><D><T><L><K><E><S><G><S><P><G><H><S><A><R><V><V><T><V><S><S><A><T><H><Y><V><A><E><L><N><M><D><D><L><Q><S><S><A><C><Y><S><P><H><A><A><Y><A><Q><S><K><L><A><L><V><L><F><T><Y><H><L><Q><R><L><L><A><A><E><G><S><H><V><T><A><N><V><V><D><P><G><V><V><N><T><D><V><Y><K><H><V><F><W><A><T><R><L><A><K><K><L><L><G><W><L><L><F><K><T><P><D><E><G><A><W><T><S><I><Y><A><A><V><T><P><E><L><E><G><V><G><G><H><Y><L><Y><N><E><K><E><T><K><S><L><H><V><T><Y><N><Q><K><L><Q><Q><Q><L><W><S><K><S><C><E><M><T><G><V><L><D><V><T><L> | Involved in the positive regulation of starvation-induced autophagy .<BOP> | Q8N5I4 |
A0A0B4J279 | TVA21_HUMAN | T cell receptor alpha variable 21 | Homo | <M><E><T><L><L><G><L><L><I><L><W><L><Q><L><Q><W><V><S><S><K><Q><E><V><T><Q><I><P><A><A><L><S><V><P><E><G><E><N><L><V><L><N><C><S><F><T><D><S><A><I><Y><N><L><Q><W><F><R><Q><D><P><G><K><G><L><T><S><L><L><L><I><Q><S><S><Q><R><E><Q><T><S><G><R><L><N><A><S><L><D><K><S><S><G><R><S><T><L><Y><I><A><A><S><Q><P><G><D><S><A><T><Y><L><C><A><V><R> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J279 |
A8MTZ0 | BBIP1_HUMAN | BBSome-interacting protein of 10 kDa | Homo | <M><L><K><A><A><A><K><R><P><E><L><S><G><K><N><T><I><S><N><N><S><D><M><A><E><V><K><S><M><F><R><E><V><L><P><K><Q><G><P><L><F><V><E><D><I><M><T><M><V><L><C><K><P><K><L><L><P><L><K><S><L><T><L><E><K><L><E><K><M><H><Q><A><A><Q><N><T><I><R><Q><Q><E><M><A><E><K><D><Q><R><Q><I><T><H> | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation.<BOP> | A8MTZ0 |
Q7Z4L0 | COX8C_HUMAN | Cytochrome c oxidase subunit VIIIC | Homo | <M><P><L><L><R><G><R><C><P><A><R><R><H><Y><R><R><L><A><L><L><G><L><Q><P><A><P><R><F><A><H><S><G><P><P><R><Q><R><P><L><S><A><A><E><M><A><V><G><L><V><V><F><F><T><T><F><L><T><P><A><A><Y><V><L><G><N><L><K><Q><F><R><R><N> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from | Q7Z4L0 |
Q9P1W8 | SIRPG_HUMAN | Signal-regulatory protein beta-2 | Homo | <M><P><V><P><A><S><W><P><H><P><P><G><P><F><L><L><L><T><L><L><L><G><L><T><E><V><A><G><E><E><E><L><Q><M><I><Q><P><E><K><L><L><L><V><T><V><G><K><T><A><T><L><H><C><T><V><T><S><L><L><P><V><G><P><V><L><W><F><R><G><V><G><P><G><R><E><L><I><Y><N><Q><K><E><G><H><F><P><R><V><T><T><V><S><D><L><T><K><R><N><N><M><D><F><S><I><R><I><S><S><I><T><P><A><D><V><G><T><Y><Y><C><V><K><F><R><K><G><S><P><E><N><V><E><F><K><S><G><P><G><T><E><M><A><L><G><A><K><P><S><A><P><V><V><L><G><P><A><A><R><T><T><P><E><H><T><V><S><F><T><C><E><S><H><G><F><S><P><R><D><I><T><L><K><W><F><K><N><G><N><E><L><S><D><F><Q><T><N><V><D><P><T><G><Q><S><V><A><Y><S><I><R><S><T><A><R><V><V><L><D><P><W><D><V><R><S><Q><V><I><C><E><V><A><H><V><T><L><Q><G><D><P><L><R><G><T><A><N><L><S><E><A><I><R><V><P><P><T><L><E><V><T><Q><Q><P><M><R><V><G><N><Q><V><N><V><T><C><Q><V><R><K><F><Y><P><Q><S><L><Q><L><T><W><S><E><N><G><N><V><C><Q><R><E><T><A><S><T><L><T><E><N><K><D><G><T><Y><N><W><T><S><W><F><L><V><N><I><S><D><Q><R><D><D><V><V><L><T><C><Q><V><K><H><D><G><Q><L><A><V><S><K><R><L><A><L><E><V><T><V><H><Q><K><D><Q><S><S><D><A><T><P><G><P><A><S><S><L><T><A><L><L><L><I><A><V><L><L><G><P><I><Y><V><P><W><K><Q><K><T> | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.<BOP> | Q9P1W8 |
Q16644 | MAPK3_HUMAN | Chromosome 3p kinase | Homo | <M><D><G><E><T><A><E><E><Q><G><G><P><V><P><P><P><V><A><P><G><G><P><G><L><G><G><A><P><G><G><R><R><E><P><K><K><Y><A><V><T><D><D><Y><Q><L><S><K><Q><V><L><G><L><G><V><N><G><K><V><L><E><C><F><H><R><R><T><G><Q><K><C><A><L><K><L><L><Y><D><S><P><K><A><R><Q><E><V><D><H><H><W><Q><A><S><G><G><P><H><I><V><C><I><L><D><V><Y><E><N><M><H><H><G><K><R><C><L><L><I><I><M><E><C><M><E><G><G><E><L><F><S><R><I><Q><E><R><G><D><Q><A><F><T><E><R><E><A><A><E><I><M><R><D><I><G><T><A><I><Q><F><L><H><S><H><N><I><A><H><R><D><V><K><P><E><N><L><L><Y><T><S><K><E><K><D><A><V><L><K><L><T><D><F><G><F><A><K><E><T><T><Q><N><A><L><Q><T><P><C><Y><T><P><Y><Y><V><A><P><E><V><L><G><P><E><K><Y><D><K><S><C><D><M><W><S><L><G><V><I><M><Y><I><L><L><C><G><F><P><P><F><Y><S><N><T><G><Q><A><I><S><P><G><M><K><R><R><I><R><L><G><Q><Y><G><F><P><N><P><E><W><S><E><V><S><E><D><A><K><Q><L><I><R><L><L><L><K><T><D><P><T><E><R><L><T><I><T><Q><F><M><N><H><P><W><I><N><Q><S><M><V><V><P><Q><T><P><L><H><T><A><R><V><L><Q><E><D><K><D><H><W><D><E><V><K><E><E><M><T><S><A><L><A><T><M><R><V><D><Y><D><Q><V><K><I><K><D><L><K><T><S><N><N><R><L><L><N><K><R><R><K><K><Q><A><G><S><S><S><A><S><Q><G><C><N><N><Q> | Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TN | Q16644 |
P45381 | ACY2_HUMAN | Aminoacylase-2 | Homo | <M><T><S><C><H><I><A><E><E><H><I><Q><K><V><A><I><F><G><G><T><H><G><N><E><L><T><G><V><F><L><V><K><H><W><L><E><N><G><A><E><I><Q><R><T><G><L><E><V><K><P><F><I><T><N><P><R><A><V><K><K><C><T><R><Y><I><D><C><D><L><N><R><I><F><D><L><E><N><L><G><K><K><M><S><E><D><L><P><Y><E><V><R><R><A><Q><E><I><N><H><L><F><G><P><K><D><S><E><D><S><Y><D><I><I><F><D><L><H><N><T><T><S><N><M><G><C><T><L><I><L><E><D><S><R><N><N><F><L><I><Q><M><F><H><Y><I><K><T><S><L><A><P><L><P><C><Y><V><Y><L><I><E><H><P><S><L><K><Y><A><T><T><R><S><I><A><K><Y><P><V><G><I><E><V><G><P><Q><P><Q><G><V><L><R><A><D><I><L><D><Q><M><R><K><M><I><K><H><A><L><D><F><I><H><H><F><N><E><G><K><E><F><P><P><C><A><I><E><V><Y><K><I><I><E><K><V><D><Y><P><R><D><E><N><G><E><I><A><A><I><I><H><P><N><L><Q><D><Q><D><W><K><P><L><H><P><G><D><P><M><F><L><T><L><D><G><K><T><I><P><L><G><G><D><C><T><V><Y><P><V><F><V><N><E><A><A><Y><Y><E><K><K><E><A><F><A><K><T><T><K><L><T><L><N><A><K><S><I><R><C><C><L><H> | Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.<BOP> | P45381 |
P27635 | RL10_HUMAN | Tumor suppressor QM | Homo | <M><G><R><R><P><A><R><C><Y><R><Y><C><K><N><K><P><Y><P><K><S><R><F><C><R><G><V><P><D><A><K><I><R><I><F><D><L><G><R><K><K><A><K><V><D><E><F><P><L><C><G><H><M><V><S><D><E><Y><E><Q><L><S><S><E><A><L><E><A><A><R><I><C><A><N><K><Y><M><V><K><S><C><G><K><D><G><F><H><I><R><V><R><L><H><P><F><H><V><I><R><I><N><K><M><L><S><C><A><G><A><D><R><L><Q><T><G><M><R><G><A><F><G><K><P><Q><G><T><V><A><R><V><H><I><G><Q><V><I><M><S><I><R><T><K><L><Q><N><K><E><H><V><I><E><A><L><R><R><A><K><F><K><F><P><G><R><Q><K><I><H><I><S><K><K><W><G><F><T><K><F><N><A><D><E><F><E><D><M><V><A><E><K><R><L><I><P><D><G><C><G><V><K><Y><I><P><S><R><G><P><L><D><K><W><R><A><L><H><S> | Component of the large ribosomal subunit . Plays a role in the formation of actively translating ribosomes . May play a role in the embryonic brain development .<BOP> | P27635 |
Q96B42 | TMM18_HUMAN | Transmembrane protein 18 | Homo | <M><P><S><A><F><S><V><S><S><F><P><V><S><I><P><A><V><L><T><Q><T><D><W><T><E><P><W><L><M><G><L><A><T><F><H><A><L><C><V><L><L><T><C><L><S><S><R><S><Y><R><L><Q><I><G><H><F><L><C><L><V><I><L><V><Y><C><A><E><Y><I><N><E><A><A><A><M><N><W><R><L><F><S><K><Y><Q><Y><F><D><S><R><G><M><F><I><S><I><V><F><S><A><P><L><L><V><N><A><M><I><I><V><V><M><W><V><W><K><T><L><N><V><M><T><D><L><K><N><A><Q><E><R><R><K><E><K><K><R><R><R><K><E><D> | Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).<BOP> | Q96B42 |
P60604 | UB2G2_HUMAN | Ubiquitin-protein ligase G2 | Homo | <M><A><G><T><A><L><K><R><L><M><A><E><Y><K><Q><L><T><L><N><P><P><E><G><I><V><A><G><P><M><N><E><E><N><F><F><E><W><E><A><L><I><M><G><P><E><D><T><C><F><E><F><G><V><F><P><A><I><L><S><F><P><L><D><Y><P><L><S><P><P><K><M><R><F><T><C><E><M><F><H><P><N><I><Y><P><D><G><R><V><C><I><S><I><L><H><A><P><G><D><D><P><M><G><Y><E><S><S><A><E><R><W><S><P><V><Q><S><V><E><K><I><L><L><S><V><V><S><M><L><A><E><P><N><D><E><S><G><A><N><V><D><A><S><K><M><W><R><D><D><R><E><Q><F><Y><K><I><A><K><Q><I><V><Q><K><S><L><G><L> | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . In vitro catalyzes 'Lys-48'-linked polyubiquitination . Involved in endoplasmic reticulum-associated degradation (ERAD) . Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation .<BOP> | P60604 |
P08686 | CP21A_HUMAN | Cytochrome P450-C21B | Homo | <M><L><L><L><G><L><L><L><L><P><L><L><A><G><A><R><L><L><W><N><W><W><K><L><R><S><L><H><L><P><P><L><A><P><G><F><L><H><L><L><Q><P><D><L><P><I><Y><L><L><G><L><T><Q><K><F><G><P><I><Y><R><L><H><L><G><L><Q><D><V><V><V><L><N><S><K><R><T><I><E><E><A><M><V><K><K><W><A><D><F><A><G><R><P><E><P><L><T><Y><K><L><V><S><K><N><Y><P><D><L><S><L><G><D><Y><S><L><L><W><K><A><H><K><K><L><T><R><S><A><L><L><L><G><I><R><D><S><M><E><P><V><V><E><Q><L><T><Q><E><F><C><E><R><M><R><A><Q><P><G><T><P><V><A><I><E><E><E><F><S><L><L><T><C><S><I><I><C><Y><L><T><F><G><D><K><I><K><D><D><N><L><M><P><A><Y><Y><K><C><I><Q><E><V><L><K><T><W><S><H><W><S><I><Q><I><V><D><V><I><P><F><L><R><F><F><P><N><P><G><L><R><R><L><K><Q><A><I><E><K><R><D><H><I><V><E><M><Q><L><R><Q><H><K><E><S><L><V><A><G><Q><W><R><D><M><M><D><Y><M><L><Q><G><V><A><Q><P><S><M><E><E><G><S><G><Q><L><L><E><G><H><V><H><M><A><A><V><D><L><L><I><G><G><T><E><T><T><A><N><T><L><S><W><A><V><V><F><L><L><H><H><P><E><I><Q><Q><R><L><Q><E><E><L><D><H><E><L><G><P><G><A><S><S><S><R><V><P><Y><K><D><R><A><R><L><P><L><L><N><A><T><I><A><E><V><L><R><L><R><P><V><V><P><L><A><L><P><H><R><T><T><R><P><S><S><I><S><G><Y><D><I><P><E><G><T><V><I><I><P><N><L><Q><G><A><H><L><D><E><T><V><W><E><R><P><H><E><F><W><P><D><R><F><L><E><P><G><K><N><S><R><A><L><A><F><G><C><G><A><R><V><C><L><G><E><P><L><A><R><L><E><L><F><V><V><L><T><R><L><L><Q><A><F><T><L><L><P><S><G><D><A><L><P><S><L><Q><P><L><P><H><C><S><V><I><L><K><M><Q><P><F><Q><V><R><L><Q><P><R><G><M><G><A><H><S><P><G><Q><N><Q> | A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .<BOP> | P08686 |
Q16690 | DUS5_HUMAN | Dual specificity protein phosphatase hVH3 | Homo | <M><K><V><T><S><L><D><G><R><Q><L><R><K><M><L><R><K><E><A><A><A><R><C><V><V><L><D><C><R><P><Y><L><A><F><A><A><S><N><V><R><G><S><L><N><V><N><L><N><S><V><V><L><R><R><A><R><G><G><A><V><S><A><R><Y><V><L><P><D><E><A><A><R><A><R><L><L><Q><E><G><G><G><G><V><A><A><V><V><V><L><D><Q><G><S><R><H><W><Q><K><L><R><E><E><S><A><A><R><V><V><L><T><S><L><L><A><C><L><P><A><G><P><R><V><Y><F><L><K><G><G><Y><E><T><F><Y><S><E><Y><P><E><C><C><V><D><V><K><P><I><S><Q><E><K><I><E><S><E><R><A><L><I><S><Q><C><G><K><P><V><V><N><V><S><Y><R><P><A><Y><D><Q><G><G><P><V><E><I><L><P><F><L><Y><L><G><S><A><Y><H><A><S><K><C><E><F><L><A><N><L><H><I><T><A><L><L><N><V><S><R><R><T><S><E><A><C><A><T><H><L><H><Y><K><W><I><P><V><E><D><S><H><T><A><D><I><S><S><H><F><Q><E><A><I><D><F><I><D><C><V><R><E><K><G><G><K><V><L><V><H><C><E><A><G><I><S><R><S><P><T><I><C><M><A><Y><L><M><K><T><K><Q><F><R><L><K><E><A><F><D><Y><I><K><Q><R><R><S><M><V><S><P><N><F><G><F><M><G><Q><L><L><Q><Y><E><S><E><I><L><P><S><T><P><N><P><Q><P><P><S><C><Q><G><E><A><A><G><S><S><L><I><G><H><L><Q><T><L><S><P><D><M><Q><G><A><Y><C><T><F><P><A><S><V><L><A><P><V><P><T><H><S><T><V><S><E><L><S><R><S><P><V><A><T><A><T><S><C> | Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.<BOP> | Q16690 |
Q99445 | GML_HUMAN | Glycosyl-phosphatidylinositol-anchored molecule-like protein | Homo | <M><L><L><F><A><L><L><L><A><M><E><L><P><L><V><A><A><S><A><T><M><R><A><Q><W><T><Y><S><L><R><C><H><D><C><A><V><I><N><D><F><N><C><P><N><I><R><V><C><P><Y><H><I><R><R><C><M><T><I><S><I><R><I><N><S><R><E><L><L><V><Y><K><N><C><T><N><N><C><T><F><V><Y><A><A><E><Q><P><P><E><A><P><G><K><I><F><K><T><N><S><F><Y><W><V><C><C><C><N><S><M><V><C><N><A><G><G><P><T><N><L><E><R><D><M><L><P><D><E><V><T><E><E><E><L><P><E><G><T><V><R><L><G><V><S><K><L><L><L><S><F><A><S><I><I><V><S><N><I><L><P> | May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.<BOP> | Q99445 |
P06732 | KCRM_HUMAN | M-CK | Homo | <M><P><F><G><N><T><H><N><K><F><K><L><N><Y><K><P><E><E><E><Y><P><D><L><S><K><H><N><N><H><M><A><K><V><L><T><L><E><L><Y><K><K><L><R><D><K><E><T><P><S><G><F><T><V><D><D><V><I><Q><T><G><V><D><N><P><G><H><P><F><I><M><T><V><G><C><V><A><G><D><E><E><S><Y><E><V><F><K><E><L><F><D><P><I><I><S><D><R><H><G><G><Y><K><P><T><D><K><H><K><T><D><L><N><H><E><N><L><K><G><G><D><D><L><D><P><N><Y><V><L><S><S><R><V><R><T><G><R><S><I><K><G><Y><T><L><P><P><H><C><S><R><G><E><R><R><A><V><E><K><L><S><V><E><A><L><N><S><L><T><G><E><F><K><G><K><Y><Y><P><L><K><S><M><T><E><K><E><Q><Q><Q><L><I><D><D><H><F><L><F><D><K><P><V><S><P><L><L><L><A><S><G><M><A><R><D><W><P><D><A><R><G><I><W><H><N><D><N><K><S><F><L><V><W><V><N><E><E><D><H><L><R><V><I><S><M><E><K><G><G><N><M><K><E><V><F><R><R><F><C><V><G><L><Q><K><I><E><E><I><F><K><K><A><G><H><P><F><M><W><N><Q><H><L><G><Y><V><L><T><C><P><S><N><L><G><T><G><L><R><G><G><V><H><V><K><L><A><H><L><S><K><H><P><K><F><E><E><I><L><T><R><L><R><L><Q><K><R><G><T><G><G><V><D><T><A><A><V><G><S><V><F><D><V><S><N><A><D><R><L><G><S><S><E><V><E><Q><V><Q><L><V><V><D><G><V><K><L><M><V><E><M><E><K><K><L><E><K><G><Q><S><I><D><D><M><I><P><A><Q><K> | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.<BOP> | P06732 |
Q9Y2W7 | CSEN_HUMAN | Kv channel-interacting protein 3 | Homo | <M><Q><P><A><K><E><V><T><K><A><S><D><G><S><L><L><G><D><L><G><H><T><P><L><S><K><K><E><G><I><K><W><Q><R><P><R><L><S><R><Q><A><L><M><R><C><C><L><V><K><W><I><L><S><S><T><A><P><Q><G><S><D><S><S><D><S><E><L><E><L><S><T><V><R><H><Q><P><E><G><L><D><Q><L><Q><A><Q><T><K><F><T><K><K><E><L><Q><S><L><Y><R><G><F><K><N><E><C><P><T><G><L><V><D><E><D><T><F><K><L><I><Y><A><Q><F><F><P><Q><G><D><A><T><T><Y><A><H><F><L><F><N><A><F><D><A><D><G><N><G><A><I><H><F><E><D><F><V><V><G><L><S><I><L><L><R><G><T><V><H><E><K><L><K><W><A><F><N><L><Y><D><I><N><K><D><G><Y><I><T><K><E><E><M><L><A><I><M><K><S><I><Y><D><M><M><G><R><H><T><Y><P><I><L><R><E><D><A><P><A><E><H><V><E><R><F><F><E><K><M><D><R><N><Q><D><G><V><V><T><I><E><E><F><L><E><A><C><Q><K><D><E><N><I><M><S><S><M><Q><L><F><E><N><V><I> | May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.<BOP> | Q9Y2W7 |
Q8IW03 | SIAH3_HUMAN | Seven in absentia homolog 3 | Homo | <M><L><F><F><T><Q><C><F><G><A><V><L><D><L><I><H><L><R><F><Q><H><Y><K><A><K><R><V><F><S><A><A><G><Q><L><V><C><V><V><N><P><T><H><N><L><K><Y><V><S><S><R><R><A><V><T><Q><S><A><P><E><Q><G><S><F><H><P><H><H><L><S><H><H><H><C><H><H><R><H><H><H><H><L><R><H><H><A><H><P><H><H><L><H><H><Q><E><A><G><L><H><A><N><P><V><T><P><C><L><C><M><C><P><L><F><S><C><Q><W><E><G><R><L><E><V><V><V><P><H><L><R><Q><I><H><R><V><D><I><L><Q><G><A><E><I><V><F><L><A><T><D><M><H><L><P><A><P><A><D><W><I><I><M><H><S><C><L><G><H><H><F><L><L><V><L><R><K><Q><E><R><H><E><G><H><P><Q><F><F><A><T><M><M><L><I><G><T><P><T><Q><A><D><C><F><T><Y><R><L><E><L><N><R><N><H><R><R><L><K><W><E><A><T><P><R><S><V><L><E><C><V><D><S><V><I><T><D><G><D><C><L><V><L><N><T><S><L><A><Q><L><F><S><D><N><G><S><L><A><I><G><I><A><I><T><A><T><E><V><L><P><S><E><A><E><M> | Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.<BOP> | Q8IW03 |
Q9UHJ6 | SHPK_HUMAN | Carbohydrate kinase-like protein | Homo | <M><A><A><R><P><I><T><L><G><I><D><L><G><T><T><S><V><K><A><A><L><L><R><A><A><P><D><D><P><S><G><F><A><V><L><A><S><C><A><R><A><A><R><A><E><A><A><V><E><S><A><V><A><G><P><Q><G><R><E><Q><D><V><S><R><I><L><Q><A><L><H><E><C><L><A><A><L><P><R><P><Q><L><R><S><V><V><G><I><G><V><S><G><Q><M><H><G><V><V><F><W><K><T><G><Q><G><C><E><W><T><E><G><G><I><T><P><V><F><E><P><R><A><V><S><H><L><V><T><W><Q><D><G><R><C><S><S><E><F><L><A><S><L><P><Q><P><K><S><H><L><S><V><A><T><G><F><G><C><A><T><I><F><W><L><L><K><Y><R><P><E><F><L><K><S><Y><D><A><A><G><T><I><H><D><Y><V><V><A><M><L><C><G><L><P><R><P><L><M><S><D><Q><N><A><A><S><W><G><Y><F><N><T><Q><S><Q><S><W><N><V><E><T><L><R><S><S><G><F><P><V><H><L><L><P><D><I><A><E><P><G><S><V><A><G><R><T><S><H><M><W><F><E><I><P><K><G><T><Q><V><G><V><A><L><G><D><L><Q><A><S><V><Y><S><C><M><A><Q><R><T><D><A><V><L><N><I><S><T><S><V><Q><L><A><A><S><M><P><S><G><F><Q><P><A><Q><T><P><D><P><T><A><P><V><A><Y><F><P><Y><F><N><R><T><Y><L><G><V><A><A><S><L><N><G><G><N><V><L><A><T><F><V><H><M><L><V><Q><W><M><A><D><L><G><L><E><V><E><E><S><T><V><Y><S><R><M><I><Q><A><A><V><Q><Q><R><D><T><H><L><T><I><T><P><T><V><L><G><E><R><H><L><P><D><Q><L><A><S><V><T><R><I><S><S><S><D><L><S><L><G><H><V><T><R><A><L><C><R><G><I><V><Q><N><L><H><S><M><L><P><I><Q><Q><L><Q><E><W><G><V><E><R><V><M><G><S><G><S><A><L><S><R><N><D><V><L><K><Q><E><V><Q><R><A><F><P><L><P><M><S><F><G><Q><D><V><D><A><A><V><G><A><A><L><V><M><L><R><R><H><L><N><Q><K><E><S> | Acts as a modulator of macrophage activation through control of glucose metabolism.<BOP> | Q9UHJ6 |
Q6NUJ1 | SAPL1_HUMAN | Saposin D-like | Homo | <M><L><C><A><L><L><L><L><P><S><L><L><G><A><T><R><A><S><P><T><S><G><P><Q><E><C><A><K><G><S><T><V><W><C><Q><D><L><Q><T><A><A><R><C><G><A><V><G><Y><C><Q><G><A><V><W><N><K><P><T><A><K><S><L><P><C><D><V><C><Q><D><I><A><A><A><A><G><N><G><L><N><P><D><A><T><E><S><D><I><L><A><L><V><M><K><T><C><E><W><L><P><S><Q><E><S><S><A><G><C><K><W><M><V><D><A><H><S><S><A><I><L><S><M><L><R><G><A><P><D><S><A><P><A><Q><V><C><T><A><L><S><L><C><E><P><L><Q><R><H><L><A><T><L><R><P><L><S><K><E><D><T><F><E><A><V><A><P><F><M><A><N><G><P><L><T><F><H><P><R><Q><A><P><E><G><A><L><C><Q><D><C><V><R><Q><V><S><R><L><Q><E><A><V><R><S><N><L><T><L><A><D><L><N><I><Q><E><Q><C><E><S><L><G><P><G><L><A><V><L><C><K><N><Y><L><F><Q><F><F><V><P><A><D><Q><A><L><R><L><L><P><P><Q><E><L><C><R><K><G><G><F><C><E><E><L><G><A><P><A><R><L><T><Q><V><V><A><M><D><G><V><P><S><L><E><L><G><L><P><R><K><Q><S><E><M><Q><M><K><A><G><V><T><C><E><V><C><M><N><V><V><Q><K><L><D><H><W><L><M><S><N><S><S><E><L><M><I><T><H><A><L><E><R><V><C><S><V><M><P><A><S><I><T><K><E><C><I><I><L><V><D><T><Y><S><P><S><L><V><Q><L><V><A><K><I><T><P><E><K><V><C><K><F><I><R><L><C><G><N><R><R><R><A><R><A><V><H><D><A><Y><A><I><V><P><S><P><E><W><D><A><E><N><Q><G><S><F><C><N><G><C><K><R><L><L><T><V><S><S><H><N><L><E><S><K><S><T><K><R><D><I><L><V><A><F><K><G><G><C><S><I><L><P><L><P><Y><M><I><Q><C><K><H><F><V><T><Q><Y><E><P><V><L><I><E><S><L><K><D><M><M><D><P><V><A><V><C><K><K><V><G><A><C><H><G><P><R><T><P><L><L><G><T><D><Q><C><A><L><G><P><S><F><W><C><R><S><Q><E><A><A><K><L><C><N><A><V><Q><H><C><Q><K><H><V><W><K><E><M><H><L><H><A><G><E><H><A> | May activate the lysosomal degradation of sphingolipids.<BOP> | Q6NUJ1 |
P0DPF4 | TVA35_HUMAN | T cell receptor alpha variable 35 | Homo | <M><L><L><E><H><L><L><I><I><L><W><M><Q><L><T><W><V><S><G><Q><Q><L><N><Q><S><P><Q><S><M><F><I><Q><E><G><E><D><V><S><M><N><C><T><S><S><S><I><F><N><T><W><L><W><Y><K><Q><E><P><G><E><G><P><V><L><L><I><A><L><Y><K><A><G><E><L><T><S><N><G><R><L><T><A><Q><F><G><I><T><R><K><D><S><F><L><N><I><S><A><S><I><P><S><D><V><G><I><Y><F><C><A><G><Q> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | P0DPF4 |
P57054 | PIGP_HUMAN | Phosphatidylinositol-glycan biosynthesis class P protein | Homo | <M><V><P><R><S><T><S><L><T><L><I><V><F><L><F><H><R><L><S><K><A><P><G><K><M><V><E><N><S><P><S><P><L><P><E><R><A><I><Y><G><F><V><L><F><L><S><S><Q><F><G><F><I><L><Y><L><V><W><A><F><I><P><E><S><W><L><N><S><L><G><L><T><Y><W><P><Q><K><Y><W><A><V><A><L><P><V><Y><L><L><I><A><I><V><I><G><Y><V><L><L><F><G><I><N><M><M><S><T><S><P><L><D><S><I><H><T><I><T><D><N><Y><A><K><N><Q><Q><Q><K><K><Y><Q><E><E><A><I><P><A><L><R><D><I><S><I><S><E><V><N><Q><M><F><F><L><A><A><K><E><L><Y><T><K><N> | Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP> | P57054 |
P53672 | CRBA2_HUMAN | Beta-A2 crystallin | Homo | <M><S><S><A><P><A><P><G><P><A><P><A><S><L><T><L><W><D><E><E><D><F><Q><G><R><R><C><R><L><L><S><D><C><A><N><V><C><E><R><G><G><L><P><R><V><R><S><V><K><V><E><N><G><V><W><V><A><F><E><Y><P><D><F><Q><G><Q><Q><F><I><L><E><K><G><D><Y><P><R><W><S><A><W><S><G><S><S><S><H><N><S><N><Q><L><L><S><F><R><P><V><L><C><A><N><H><N><D><S><R><V><T><L><F><E><G><D><N><F><Q><G><C><K><F><D><L><V><D><D><Y><P><S><L><P><S><M><G><W><A><S><K><D><V><G><S><L><K><V><S><S><G><A><W><V><A><Y><Q><Y><P><G><Y><R><G><Y><Q><Y><V><L><E><R><D><R><H><S><G><E><F><C><T><Y><G><E><L><G><T><Q><A><H><T><G><Q><L><Q><S><I><R><R><V><Q><H> | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> | P53672 |
Q9UQK1 | PPR3C_HUMAN | Protein targeting to glycogen | Homo | <M><S><C><T><R><M><I><Q><V><L><D><P><R><P><L><T><S><S><V><M><P><V><D><V><A><M><R><L><C><L><A><H><S><P><P><V><K><S><F><L><G><P><Y><D><E><F><Q><R><R><H><F><V><N><K><L><K><P><L><K><S><C><L><N><I><K><H><K><A><K><S><Q><N><D><W><K><C><S><H><N><Q><A><K><K><R><V><V><F><A><D><S><K><G><L><S><L><T><A><I><H><V><F><S><D><L><P><E><E><P><A><W><D><L><Q><F><D><L><L><D><L><N><D><I><S><S><A><L><K><H><H><E><E><K><N><L><I><L><D><F><P><Q><P><S><T><D><Y><L><S><F><R><S><H><F><Q><K><N><F><V><C><L><E><N><C><S><L><Q><E><R><T><V><T><G><T><V><K><V><K><N><V><S><F><E><K><K><V><Q><I><R><I><T><F><D><S><W><K><N><Y><T><D><V><D><C><V><Y><M><K><N><V><Y><G><G><T><D><S><D><T><F><S><F><A><I><D><L><P><P><V><I><P><T><E><Q><K><I><E><F><C><I><S><Y><H><A><N><G><Q><V><F><W><D><N><N><D><G><Q><N><Y><R><I><V><H><V><Q><W><K><P><D><G><V><Q><T><Q><M><A><P><Q><D><C><A><F><H><Q><T><S><P><K><T><E><L><E><S><T><I><F><G><S><P><R><L><A><S><G><L><F><P><E><W><Q><S><W><G><R><M><E><N><L><A><S><Y><R> | Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.<BOP> | Q9UQK1 |
Q96AW1 | VOPP1_HUMAN | Putative NF-kappa-B-activating protein 055N | Homo | <M><R><R><Q><P><A><K><V><A><A><L><L><L><G><L><L><L><E><C><T><E><A><K><K><H><C><W><Y><F><E><G><L><Y><P><T><Y><Y><I><C><R><S><Y><E><D><C><C><G><S><R><C><C><V><R><A><L><S><I><Q><R><L><W><Y><F><W><F><L><L><M><M><G><V><L><F><C><C><G><A><G><F><F><I><R><R><R><M><Y><P><P><P><L><I><E><E><P><A><F><N><V><S><Y><T><R><Q><P><P><N><P><G><P><G><A><Q><Q><P><G><P><P><Y><Y><T><D><P><G><G><P><G><M><N><P><V><G><N><S><M><A><M><A><F><Q><V><P><P><N><S><P><Q><G><S><V><A><C><P><P><P><P><A><Y><C><N><T><P><P><P><P><Y><E><Q><V><V><K><A><K> | Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.<BOP> | Q96AW1 |
P49961 | ENTP1_HUMAN | Lymphoid cell activation antigen | Homo | <M><E><D><T><K><E><S><N><V><K><T><F><C><S><K><N><I><L><A><I><L><G><F><S><S><I><I><A><V><I><A><L><L><A><V><G><L><T><Q><N><K><A><L><P><E><N><V><K><Y><G><I><V><L><D><A><G><S><S><H><T><S><L><Y><I><Y><K><W><P><A><E><K><E><N><D><T><G><V><V><H><Q><V><E><E><C><R><V><K><G><P><G><I><S><K><F><V><Q><K><V><N><E><I><G><I><Y><L><T><D><C><M><E><R><A><R><E><V><I><P><R><S><Q><H><Q><E><T><P><V><Y><L><G><A><T><A><G><M><R><L><L><R><M><E><S><E><E><L><A><D><R><V><L><D><V><V><E><R><S><L><S><N><Y><P><F><D><F><Q><G><A><R><I><I><T><G><Q><E><E><G><A><Y><G><W><I><T><I><N><Y><L><L><G><K><F><S><Q><K><T><R><W><F><S><I><V><P><Y><E><T><N><N><Q><E><T><F><G><A><L><D><L><G><G><A><S><T><Q><V><T><F><V><P><Q><N><Q><T><I><E><S><P><D><N><A><L><Q><F><R><L><Y><G><K><D><Y><N><V><Y><T><H><S><F><L><C><Y><G><K><D><Q><A><L><W><Q><K><L><A><K><D><I><Q><V><A><S><N><E><I><L><R><D><P><C><F><H><P><G><Y><K><K><V><V><N><V><S><D><L><Y><K><T><P><C><T><K><R><F><E><M><T><L><P><F><Q><Q><F><E><I><Q><G><I><G><N><Y><Q><Q><C><H><Q><S><I><L><E><L><F><N><T><S><Y><C><P><Y><S><Q><C><A><F><N><G><I><F><L><P><P><L><Q><G><D><F><G><A><F><S><A><F><Y><F><V><M><K><F><L><N><L><T><S><E><K><V><S><Q><E><K><V><T><E><M><M><K><K><F><C><A><Q><P><W><E><E><I><K><T><S><Y><A><G><V><K><E><K><Y><L><S><E><Y><C><F><S><G><T><Y><I><L><S><L><L><L><Q><G><Y><H><F><T><A><D><S><W><E><H><I><H><F><I><G><K><I><Q><G><S><D><A><G><W><T><L><G><Y><M><L><N><L><T><N><M><I><P><A><E><Q><P><L><S><T><P><L><S><H><S><T><Y><V><F><L><M><V><L><F><S><L><V><L><F><T><V><A><I><I><G><L><L><I><F><H><K><P><S><Y><F><W><K><D><M><V> | In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.<BOP> | P49961 |
Q8WUP2 | FBLI1_HUMAN | Mitogen-inducible 2-interacting protein | Homo | <M><A><S><K><P><E><K><R><V><A><S><S><V><F><I><T><L><A><P><P><R><R><D><V><A><V><A><E><E><V><R><Q><A><V><C><E><A><R><R><G><R><P><W><E><A><P><A><P><M><K><T><P><E><A><G><L><A><G><R><P><S><P><W><T><T><P><G><R><A><A><A><T><V><P><A><A><P><M><Q><L><F><N><G><G><C><P><P><P><P><P><V><L><D><G><E><D><V><L><P><D><L><D><L><L><P><P><P><P><P><P><P><P><V><L><L><P><S><E><E><E><A><P><A><P><M><G><A><S><L><I><A><D><L><E><Q><L><H><L><S><P><P><P><P><P><P><Q><A><P><A><E><G><P><S><V><Q><P><G><P><L><R><P><M><E><E><E><L><P><P><P><P><A><E><P><V><E><K><G><A><S><T><D><I><C><A><F><C><H><K><T><V><S><P><R><E><L><A><V><E><A><M><K><R><Q><Y><H><A><Q><C><F><T><C><R><T><C><R><R><Q><L><A><G><Q><S><F><Y><Q><K><D><G><R><P><L><C><E><P><C><Y><Q><D><T><L><E><R><C><G><K><C><G><E><V><V><R><D><H><I><I><R><A><L><G><Q><A><F><H><P><S><C><F><T><C><V><T><C><A><R><C><I><G><D><E><S><F><A><L><G><S><Q><N><E><V><Y><C><L><D><D><F><Y><R><K><F><A><P><V><C><S><I><C><E><N><P><I><I><P><R><D><G><K><D><A><F><K><I><E><C><M><G><R><N><F><H><E><N><C><Y><R><C><E><D><C><R><I><L><L><S><V><E><P><T><D><Q><G><C><Y><P><L><N><N><H><L><F><C><K><P><C><H><V><K><R><S><A><A><G><C><C> | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.<BOP> | Q8WUP2 |
A8MVU1 | NCF1C_HUMAN | Putative SH3 and PX domain-containing protein 1C | Homo | <M><Y><M><F><L><V><K><W><Q><D><L><S><E><K><V><V><Y><R><R><F><T><E><I><Y><E><F><H><K><T><L><K><E><M><F><P><I><E><A><G><A><I><N><P><E><N><R><I><I><P><H><L><P><A><P><K><W><F><D><G><Q><R><A><A><E><N><H><Q><G><T><L><T><E><Y><C><S><T><L><M><S><L><P><T><K><I><S><R><C><P><H><L><L><D><F><F><K><V><R><P><D><D><L><K><L><P><T><D><N><Q><T><K><K><P><E><T><Y><L><M><P><K><D><G><K><S><T><A><T><D><I><T><G><P><I><I><L><Q><T><Y><R><A><I><A><D><Y><E><K><T><S><G><S><E><M><A><L><S><T><G><D><V><V><E><V><V><E><K><S><E><S><G><W><W><F><C><Q><M><K><A><K><R><G><W><I><P><A><S><F><L><E><P><L><D><S><P><D><E><T><E><D><P><E><P><N><Y><A><G><E><P><Y><V><A><I><K><A><Y><T><A><V><E><G><D><E><V><S><L><L><E><G><E><A><V><E><V><I><H><K><L><L><D><G><W><W><V><I><R><K><D><D><V><T><G><Y><F><P><S><M><Y><L><Q><K><S><G><Q><D><V><S><Q><A><Q><R><Q><I><K><R><G><A><P><P><R><R><S><S><I><R><N><A><H><S><I><H><Q><R><S><R><K><R><L><S><Q><D><A><Y><R><R><N><S><V><R><F><L><Q><Q><R><R><R><Q><A><R><P><G><P><Q><S><P><G><S><P><L><E><E><E><R><Q><T><Q><R><S><K><P><Q><P><A><V><P><P><R><P><S><A><D><L><I><L><N><R><C><S><E><S><T><K><R><K><L><A><S><A><V> | May be required for activation of the latent NADPH oxidase (necessary for superoxide production).<BOP> | A8MVU1 |
P61587 | RND3_HUMAN | Rnd3 | Homo | <M><K><E><R><R><A><S><Q><K><L><S><S><K><S><I><M><D><P><N><Q><N><V><K><C><K><I><V><V><V><G><D><S><Q><C><G><K><T><A><L><L><H><V><F><A><K><D><C><F><P><E><N><Y><V><P><T><V><F><E><N><Y><T><A><S><F><E><I><D><T><Q><R><I><E><L><S><L><W><D><T><S><G><S><P><Y><Y><D><N><V><R><P><L><S><Y><P><D><S><D><A><V><L><I><C><F><D><I><S><R><P><E><T><L><D><S><V><L><K><K><W><K><G><E><I><Q><E><F><C><P><N><T><K><M><L><L><V><G><C><K><S><D><L><R><T><D><V><S><T><L><V><E><L><S><N><H><R><Q><T><P><V><S><Y><D><Q><G><A><N><M><A><K><Q><I><G><A><A><T><Y><I><E><C><S><A><L><Q><S><E><N><S><V><R><D><I><F><H><V><A><T><L><A><C><V><N><K><T><N><K><N><V><K><R><N><K><S><Q><R><A><T><K><R><I><S><H><M><P><S><R><P><E><L><S><A><V><A><T><D><L><R><K><D><K><A><K><S><C><T><V><M> | Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.<BOP> | P61587 |
C9JLW8 | MCRI1_HUMAN | Protein FAM195B | Homo | <M><T><S><S><P><V><S><R><V><V><Y><N><G><K><R><T><S><S><P><R><S><P><P><S><S><S><E><I><F><T><P><A><H><E><E><N><V><R><F><I><Y><E><A><W><Q><G><V><E><R><D><L><R><G><Q><V><P><G><G><E><R><G><L><V><E><E><Y><V><E><K><V><P><N><P><S><L><K><T><F><K><P><I><D><L><S><D><L><K><R><R><S><T><Q><D><A><K><K><S> | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition .<BOP> | C9JLW8 |
P28838 | AMPL_HUMAN | Prolyl aminopeptidase | Homo | <M><F><L><L><P><L><P><A><A><G><R><V><V><V><R><R><L><A><V><R><R><F><G><S><R><S><L><S><T><A><D><M><T><K><G><L><V><L><G><I><Y><S><K><E><K><E><D><D><V><P><Q><F><T><S><A><G><E><N><F><D><K><L><L><A><G><K><L><R><E><T><L><N><I><S><G><P><P><L><K><A><G><K><T><R><T><F><Y><G><L><H><Q><D><F><P><S><V><V><L><V><G><L><G><K><K><A><A><G><I><D><E><Q><E><N><W><H><E><G><K><E><N><I><R><A><A><V><A><A><G><C><R><Q><I><Q><D><L><E><L><S><S><V><E><V><D><P><C><G><D><A><Q><A><A><A><E><G><A><V><L><G><L><Y><E><Y><D><D><L><K><Q><K><K><K><M><A><V><S><A><K><L><Y><G><S><G><D><Q><E><A><W><Q><K><G><V><L><F><A><S><G><Q><N><L><A><R><Q><L><M><E><T><P><A><N><E><M><T><P><T><R><F><A><E><I><I><E><K><N><L><K><S><A><S><S><K><T><E><V><H><I><R><P><K><S><W><I><E><E><Q><A><M><G><S><F><L><S><V><A><K><G><S><D><E><P><P><V><F><L><E><I><H><Y><K><G><S><P><N><A><N><E><P><P><L><V><F><V><G><K><G><I><T><F><D><S><G><G><I><S><I><K><A><S><A><N><M><D><L><M><R><A><D><M><G><G><A><A><T><I><C><S><A><I><V><S><A><A><K><L><N><L><P><I><N><I><I><G><L><A><P><L><C><E><N><M><P><S><G><K><A><N><K><P><G><D><V><V><R><A><K><N><G><K><T><I><Q><V><D><N><T><D><A><E><G><R><L><I><L><A><D><A><L><C><Y><A><H><T><F><N><P><K><V><I><L><N><A><A><T><L><T><G><A><M><D><V><A><L><G><S><G><A><T><G><V><F><T><N><S><S><W><L><W><N><K><L><F><E><A><S><I><E><T><G><D><R><V><W><R><M><P><L><F><E><H><Y><T><R><Q><V><V><D><C><Q><L><A><D><V><N><N><I><G><K><Y><R><S><A><G><A><C><T><A><A><A><F><L><K><E><F><V><T><H><P><K><W><A><H><L><D><I><A><G><V><M><T><N><K><D><E><V><P><Y><L><R><K><G><M><T><G><R><P><T><R><T><L><I><E><F><L><L><R><F><S><Q><D><N><A> | Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.<BOP> | P28838 |
Q9UBG3 | CRNN_HUMAN | Tumor-related protein | Homo | <M><P><Q><L><L><Q><N><I><N><G><I><I><E><A><F><R><R><Y><A><R><T><E><G><N><C><T><A><L><T><R><G><E><L><K><R><L><L><E><Q><E><F><A><D><V><I><V><K><P><H><D><P><A><T><V><D><E><V><L><R><L><L><D><E><D><H><T><G><T><V><E><F><K><E><F><L><V><L><V><F><K><V><A><Q><A><C><F><K><T><L><S><E><S><A><E><G><A><C><G><S><Q><E><S><G><S><L><H><S><G><A><S><Q><E><L><G><E><G><Q><R><S><G><T><E><V><G><R><A><G><K><G><Q><H><Y><E><G><S><S><H><R><Q><S><Q><Q><G><S><R><G><Q><N><R><P><G><V><Q><T><Q><G><Q><A><T><G><S><A><W><V><S><S><Y><D><R><Q><A><E><S><Q><S><Q><E><R><I><S><P><Q><I><Q><L><S><G><Q><T><E><Q><T><Q><K><A><G><E><G><K><R><N><Q><T><T><E><M><R><P><E><R><Q><P><Q><T><R><E><Q><D><R><A><H><Q><T><G><E><T><V><T><G><S><G><T><Q><T><Q><A><G><A><T><Q><T><V><E><Q><D><S><S><H><Q><T><G><R><T><S><K><Q><T><Q><E><A><T><N><D><Q><N><R><G><T><E><T><H><G><Q><G><R><S><Q><T><S><Q><A><V><T><G><G><H><A><Q><I><Q><A><G><T><H><T><Q><T><P><T><Q><T><V><E><Q><D><S><S><H><Q><T><G><S><T><S><T><Q><T><Q><E><S><T><N><G><Q><N><R><G><T><E><I><H><G><Q><G><R><S><Q><T><S><Q><A><V><T><G><G><H><T><Q><I><Q><A><G><S><H><T><E><T><V><E><Q><D><R><S><Q><T><V><S><H><G><G><A><R><E><Q><G><Q><T><Q><T><Q><P><G><S><G><Q><R><W><M><Q><V><S><N><P><E><A><G><E><T><V><P><G><G><Q><A><Q><T><G><A><S><T><E><S><G><R><Q><E><W><S><S><T><H><P><R><R><C><V><T><E><G><Q><G><D><R><Q><P><T><V><V><G><E><E><W><V><D><D><H><S><R><E><T><V><I><L><R><L><D><Q><G><N><L><H><T><S><V><S><S><A><Q><G><Q><D><A><A><Q><S><E><E><K><R><G><I><T><A><R><E><L><Y><S><Y><L><R><S><T><K><P> | Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 . Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways .<BOP> | Q9UBG3 |
P09497 | CLCB_HUMAN | Clathrin light chain B | Homo | <M><A><D><D><F><G><F><F><S><S><S><E><S><G><A><P><E><A><A><E><E><D><P><A><A><A><F><L><A><Q><Q><E><S><E><I><A><G><I><E><N><D><E><G><F><G><A><P><A><G><S><H><A><A><P><A><Q><P><G><P><T><S><G><A><G><S><E><D><M><G><T><T><V><N><G><D><V><F><Q><E><A><N><G><P><A><D><G><Y><A><A><I><A><Q><A><D><R><L><T><Q><E><P><E><S><I><R><K><W><R><E><E><Q><R><K><R><L><Q><E><L><D><A><A><S><K><V><T><E><Q><E><W><R><E><K><A><K><K><D><L><E><E><W><N><Q><R><Q><S><E><Q><V><E><K><N><K><I><N><N><R><I><A><D><K><A><F><Y><Q><Q><P><D><A><D><I><I><G><Y><V><A><S><E><E><A><F><V><K><E><S><K><E><E><T><P><G><T><E><W><E><K><V><A><Q><L><C><D><F><N><P><K><S><S><K><Q><C><K><D><V><S><R><L><R><S><V><L><M><S><L><K><Q><T><P><L><S><R> | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.<BOP> | P09497 |
Q69YI7 | NAIF1_HUMAN | Nuclear apoptosis-inducing factor 1 | Homo | <M><A><V><P><A><K><K><R><K><M><N><F><S><E><R><E><V><E><I><I><V><E><E><L><E><L><K><K><H><L><L><V><N><H><F><N><A><G><V><P><L><A><A><K><S><A><A><W><H><G><I><L><R><R><V><N><A><V><A><T><C><R><R><E><L><P><E><V><K><K><K><W><S><D><L><K><T><E><V><R><R><K><V><A><Q><V><R><A><A><V><E><G><G><E><A><P><G><P><T><E><E><D><G><A><G><G><P><G><T><G><G><G><S><G><G><G><G><P><A><V><A><P><V><L><L><T><P><M><Q><Q><R><I><C><N><L><L><G><E><A><T><I><I><S><L><P><S><T><T><E><I><H><P><V><A><L><G><P><S><A><T><A><A><A><A><T><V><T><L><T><Q><I><P><T><E><T><T><Y><H><T><L><E><E><G><V><V><E><Y><C><T><A><E><A><P><P><P><L><P><P><E><T><P><V><D><M><M><A><Q><H><A><D><T><S><V><K><P><Q><A><L><K><S><R><I><A><L><N><S><A><K><L><I><Q><E><Q><R><V><T><N><L><H><V><K><E><I><A><Q><H><L><E><Q><Q><N><D><L><L><Q><M><I><R><R><S><Q><E><V><Q><A><C><A><Q><E><R><Q><A><Q><A><M><E><G><T><Q><A><A><L><S><V><L><I><Q><V><L><R><P><M><I><K><D><F><R><R><Y><L><Q><S><N><T><A><N><P><A><P><A><S><D><P><G><Q><V><A><Q><N><G><Q><P><D><S><I><I><Q> | Induces apoptosis.<BOP> | Q69YI7 |
A6NFT4 | CFA73_HUMAN | Coiled-coil domain-containing protein 42B | Homo | <M><A><V><P><W><E><E><Y><F><R><L><A><L><Q><E><K><L><S><T><K><L><P><E><Q><A><E><D><H><V><P><P><V><L><R><L><L><E><K><R><Q><E><L><V><D><A><D><Q><A><L><Q><A><Q><K><E><V><F><R><T><K><T><A><A><L><K><Q><R><W><E><Q><L><E><Q><K><E><R><E><L><K><G><S><F><I><R><F><D><K><F><L><Q><D><S><E><A><R><R><N><R><A><L><R><R><A><A><E><E><R><H><Q><A><G><R><R><E><V><E><A><L><R><L><W><T><Q><L><Q><E><L><R><R><E><H><A><R><L><Q><R><R><L><K><R><L><E><P><C><A><R><L><L><E><Q><A><L><E><L><L><P><G><F><Q><E><V><P><E><L><V><A><R><F><D><G><L><A><E><T><Q><A><A><L><R><L><R><E><R><E><Q><L><A><E><L><E><A><A><R><A><R><L><Q><Q><L><R><D><A><W><P><D><E><V><L><A><Q><G><Q><R><R><A><Q><L><Q><E><R><L><E><A><A><R><E><R><T><L><Q><W><E><S><K><W><I><Q><I><Q><N><T><A><A><E><K><T><L><L><L><G><R><S><R><M><A><V><L><N><L><F><Q><L><V><C><Q><H><Q><G><Q><P><P><T><L><D><I><E><D><T><E><G><Q><L><E><H><V><K><L><F><M><Q><D><L><S><A><M><L><A><G><L><G><Q><A><E><P><A><A><P><A><S> | May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.<BOP> | A6NFT4 |
A6NMZ5 | O4C45_HUMAN | Olfactory receptor 4C45 | Homo | <M><N><N><V><T><E><F><I><L><L><G><L><T><H><N><P><E><L><Q><K><F><L><F><V><M><F><L><I><T><Y><L><I><T><L><A><G><N><L><L><I><S><V><I><I><F><I><S><P><A><L><G><S><P><M><Y><L><F><L><S><Y><L><S><I><I><D><I><F><Y><S><S><S><I><A><P><K><M><I><F><D><L><I><S><E><N><N><T><I><S><F><N><G><C><M><T><Q><L><F><T><E><H><F><F><A><A><A><E><T><I><L><L><S><V><M><A><Y><D><C><Y><V><A><I><C><K><P><L><H><Y><A><T><I><M><T><Q><S><M><C><G><F><L><M><V><V><A><G><I><L><G><F><V><H><G><G><I><Q><T><L><F><I><A><Q><L><P><F><C><G><P><N><V><I><D><H><F><M><C><D><L><V><P><L><L><E><L><A><C><T><D><T><H><T><L><G><P><L><I><A><A><N><S><G><S><L><C><F><L><I><F><S><I><L><D><A><S><Y><V><I><I><L><C><S><L><R><S><H><S><S><E><G><H><L><K><A><L><S><S><C><A><S><H><I><F><T><V><I><L><F><F><V><P><C><S><Y><L><Y><L><R><P><L><T><S><F><P><T><D><K><A><V><T><V><F><C><T><L><F><T><P><M><L><N><P><L><I><Y><T><V><K><N><K><A><V><K><N><V><I><K><K><L><W><K><Q><I><M><T><T><D><D><K> | Odorant receptor.<BOP> | A6NMZ5 |
P30085 | KCY_HUMAN | Uridine monophosphate/cytidine monophosphate kinase | Homo | <M><K><P><L><V><V><F><V><L><G><G><P><G><A><G><K><G><T><Q><C><A><R><I><V><E><K><Y><G><Y><T><H><L><S><A><G><E><L><L><R><D><E><R><K><N><P><D><S><Q><Y><G><E><L><I><E><K><Y><I><K><E><G><K><I><V><P><V><E><I><T><I><S><L><L><K><R><E><M><D><Q><T><M><A><A><N><A><Q><K><N><K><F><L><I><D><G><F><P><R><N><Q><D><N><L><Q><G><W><N><K><T><M><D><G><K><A><D><V><S><F><V><L><F><F><D><C><N><N><E><I><C><I><E><R><C><L><E><R><G><K><S><S><G><R><S><D><D><N><R><E><S><L><E><K><R><I><Q><T><Y><L><Q><S><T><K><P><I><I><D><L><Y><E><E><M><G><K><V><K><K><I><D><A><S><K><S><V><D><E><V><F><D><E><V><V><Q><I><F><D><K><E><G> | Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.<BOP> | P30085 |
P52738 | ZN140_HUMAN | Zinc finger protein 140 | Homo | <M><S><Q><G><S><V><T><F><R><D><V><A><I><D><F><S><Q><E><E><W><K><W><L><Q><P><A><Q><R><D><L><Y><R><C><V><M><L><E><N><Y><G><H><L><V><S><L><G><L><S><I><S><K><P><D><V><V><S><L><L><E><Q><G><K><E><P><W><L><G><K><R><E><V><K><R><D><L><F><S><V><S><E><S><S><G><E><I><K><D><F><S><P><K><N><V><I><Y><D><D><S><S><Q><Y><L><I><M><E><R><I><L><S><Q><G><P><V><Y><S><S><F><K><G><G><W><K><C><K><D><H><T><E><M><L><Q><E><N><Q><G><C><I><R><K><V><T><V><S><H><Q><E><A><L><A><Q><H><M><N><I><S><T><V><E><R><P><Y><G><C><H><E><C><G><K><T><F><G><R><R><F><S><L><V><L><H><Q><R><T><H><T><G><E><K><P><Y><A><C><K><E><C><G><K><T><F><S><Q><I><S><N><L><V><K><H><Q><M><I><H><T><G><K><K><P><H><E><C><K><D><C><N><K><T><F><S><Y><L><S><F><L><I><E><H><Q><R><T><H><T><G><E><K><P><Y><E><C><T><E><C><G><K><A><F><S><R><A><S><N><L><T><R><H><Q><R><I><H><I><G><K><K><Q><Y><I><C><R><K><C><G><K><A><F><S><S><G><S><E><L><I><R><H><Q><I><T><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><R><R><F><S><H><L><T><R><H><Q><S><I><H><T><T><K><T><P><Y><E><C><N><E><C><R><K><A><F><R><C><H><S><F><L><I><K><H><Q><R><I><H><A><G><E><K><L><Y><E><C><D><E><C><G><K><V><F><T><W><H><A><S><L><I><Q><H><T><K><S><H><T><G><E><K><P><Y><A><C><A><E><C><D><K><A><F><S><R><S><F><S><L><I><L><H><Q><R><T><H><T><G><E><K><P><Y><V><C><K><V><C><N><K><S><F><S><W><S><S><N><L><A><K><H><Q><R><T><H><T><L><D><N><P><Y><E><Y><E><N><S><F><N><Y><H><S><F><L><T><E><H><Q> | May be involved in transcriptional regulation as a repressor.<BOP> | P52738 |
P98173 | FAM3A_HUMAN | Cytokine-like protein 2-19 | Homo | <M><R><L><A><G><P><L><R><I><V><V><L><V><V><S><V><G><V><T><W><I><V><V><S><I><L><L><G><G><P><G><S><G><F><P><R><I><Q><Q><L><F><T><S><P><E><S><S><V><T><A><A><P><R><A><R><K><Y><K><C><G><L><P><Q><P><C><P><E><E><H><L><A><F><R><V><V><S><G><A><A><N><V><I><G><P><K><I><C><L><E><D><K><M><L><M><S><S><V><K><D><N><V><G><R><G><L><N><I><A><L><V><N><G><V><S><G><E><L><I><E><A><R><A><F><D><M><W><A><G><D><V><N><D><L><L><K><F><I><R><P><L><H><E><G><T><L><V><F><V><A><S><Y><D><D><P><A><T><K><M><N><E><E><T><R><K><L><F><S><E><L><G><S><R><N><A><K><E><L><A><F><R><D><S><W><V><F><V><G><A><K><G><V><Q><N><K><S><P><F><E><Q><H><V><K><N><S><K><H><S><N><K><Y><E><G><W><P><E><A><L><E><M><E><G><C><I><P><R><R><S><T><A><S> | May act as a defensin against invading fungal microorganisms.<BOP> | P98173 |
O00238 | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B | Homo | <M><L><L><R><S><A><G><K><L><N><V><G><T><K><K><E><D><G><E><S><T><A><P><T><P><R><P><K><V><L><R><C><K><C><H><H><H><C><P><E><D><S><V><N><N><I><C><S><T><D><G><Y><C><F><T><M><I><E><E><D><D><S><G><L><P><V><V><T><S><G><C><L><G><L><E><G><S><D><F><Q><C><R><D><T><P><I><P><H><Q><R><R><S><I><E><C><C><T><E><R><N><E><C><N><K><D><L><H><P><T><L><P><P><L><K><N><R><D><F><V><D><G><P><I><H><H><R><A><L><L><I><S><V><T><V><C><S><L><L><L><V><L><I><I><L><F><C><Y><F><R><Y><K><R><Q><E><T><R><P><R><Y><S><I><G><L><E><Q><D><E><T><Y><I><P><P><G><E><S><L><R><D><L><I><E><Q><S><Q><S><S><G><S><G><S><G><L><P><L><L><V><Q><R><T><I><A><K><Q><I><Q><M><V><K><Q><I><G><K><G><R><Y><G><E><V><W><M><G><K><W><R><G><E><K><V><A><V><K><V><F><F><T><T><E><E><A><S><W><F><R><E><T><E><I><Y><Q><T><V><L><M><R><H><E><N><I><L><G><F><I><A><A><D><I><K><G><T><G><S><W><T><Q><L><Y><L><I><T><D><Y><H><E><N><G><S><L><Y><D><Y><L><K><S><T><T><L><D><A><K><S><M><L><K><L><A><Y><S><S><V><S><G><L><C><H><L><H><T><E><I><F><S><T><Q><G><K><P><A><I><A><H><R><D><L><K><S><K><N><I><L><V><K><K><N><G><T><C><C><I><A><D><L><G><L><A><V><K><F><I><S><D><T><N><E><V><D><I><P><P><N><T><R><V><G><T><K><R><Y><M><P><P><E><V><L><D><E><S><L><N><R><N><H><F><Q><S><Y><I><M><A><D><M><Y><S><F><G><L><I><L><W><E><V><A><R><R><C><V><S><G><G><I><V><E><E><Y><Q><L><P><Y><H><D><L><V><P><S><D><P><S><Y><E><D><M><R><E><I><V><C><I><K><K><L><R><P><S><F><P><N><R><W><S><S><D><E><C><L><R><Q><M><G><K><L><M><T><E><C><W><A><H><N><P><A><S><R><L><T><A><L><R><V><K><K><T><L><A><K><M><S><E><S><Q><D><I><K><L> | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.<BOP> | O00238 |
A0A075B6K0 | LV316_HUMAN | Immunoglobulin lambda variable 3-16 | Homo | <M><A><W><I><P><L><L><L><P><L><L><T><L><C><T><G><S><E><A><S><Y><E><L><T><Q><P><P><S><V><S><V><S><L><G><Q><M><A><R><I><T><C><S><G><E><A><L><P><K><K><Y><A><Y><W><Y><Q><Q><K><P><G><Q><F><P><V><L><V><I><Y><K><D><S><E><R><P><S><G><I><P><E><R><F><S><G><S><S><S><G><T><I><V><T><L><T><I><S><G><V><Q><A><E><D><E><A><D><Y><Y><C><L><S><A><D><S><S><G><T><Y> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6K0 |
Q9Y2G4 | ANKR6_HUMAN | Diversin | Homo | <M><S><Q><Q><D><A><V><A><A><L><S><E><R><L><L><V><A><A><Y><K><G><Q><T><E><N><V><V><Q><L><I><N><K><G><A><R><V><A><V><T><K><H><G><R><T><P><L><H><L><A><A><N><K><G><H><L><P><V><V><Q><I><L><L><K><A><G><C><D><L><D><V><Q><D><D><G><D><Q><T><A><L><H><R><A><T><V><V><G><N><T><E><I><I><A><A><L><I><H><E><G><C><A><L><D><R><Q><D><K><D><G><N><T><A><L><H><E><A><S><W><H><G><F><S><Q><S><A><K><L><L><I><K><A><G><A><N><V><L><A><K><N><K><A><G><N><T><A><L><H><L><A><C><Q><N><S><H><S><Q><S><T><R><V><L><L><L><A><G><S><R><A><D><L><K><N><N><A><G><D><T><C><L><H><V><A><A><R><Y><N><H><L><S><I><I><R><L><L><L><T><A><F><C><S><V><H><E><K><N><Q><A><G><D><T><A><L><H><V><A><A><A><L><N><H><K><K><V><A><K><I><L><L><E><A><G><A><D><T><T><I><V><N><N><A><G><Q><T><P><L><E><T><A><R><Y><H><N><N><P><E><V><A><L><L><L><T><K><A><P><Q><V><L><R><F><S><R><G><R><S><L><R><K><K><R><E><R><L><K><E><E><R><R><A><Q><S><V><P><R><D><E><V><A><Q><S><K><G><S><V><S><A><G><D><T><P><S><S><E><Q><A><V><A><R><K><E><E><A><R><E><E><F><L><S><A><S><P><E><P><R><A><K><D><D><R><R><R><K><S><R><P><K><V><S><A><F><S><D><P><T><P><P><A><D><Q><Q><P><G><H><Q><K><N><L><H><A><H><N><H><P><K><K><R><N><R><H><R><C><S><S><P><P><P><P><H><E><F><R><A><Y><Q><L><Y><T><L><Y><R><G><K><D><G><K><V><M><Q><A><P><I><N><G><C><R><C><E><P><L><I><N><K><L><E><N><Q><L><E><A><T><V><E><E><I><K><A><E><L><G><S><V><Q><D><K><M><N><T><K><L><G><Q><M><E><N><K><T><Q><H><Q><M><R><V><L><D><K><L><M><V><E><R><L><S><A><E><R><T><E><C><L><N><R><L><Q><Q><H><S><D><T><E><K><H><E><G><E><K><R><Q><I><S><L><V><D><E><L><K><T><W><C><M><L><K><I><Q><N><L><E><Q><K><L><S><G><D><S><R><A><C><R><A><K><S><T><P><S><T><C><E><S><S><T><G><V><D><Q><L><V><V><T><A><G><P><A><A><A><S><D><S><S><P><P><V><V><R><P><K><E><K><A><L><N><S><T><A><T><Q><R><L><Q><Q><E><L><S><S><S><D><C><T><G><S><R><L><R><N><V><K><V><Q><T><A><L><L><P><M><N><E><A><A><R><S><D><Q><Q><A><G><P><C><V><N><R><G><T><Q><T><K><K><S><G><K><S><G><P><T><R><H><R><A><Q><Q><P><A><A><S><S><T><C><G><Q><P><P><P><A><T><G><S><E><Q><T><G><P><H><I><R><D><T><S><Q><A><L><E><L><T><Q><Y><F><F><E><A><V><S><T><Q><M><E><K><W><Y><E><R><K><I><E><E><A><R><S><Q><A><N><Q><K><A><Q><Q><D><K><A><T><L><K><E><H><I><K><S><L><E><E><E><L><A><K><L><R><T><R><V><Q><K><E><N> | Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.<BOP> | Q9Y2G4 |
Q969E8 | TSR2_HUMAN | Pre-rRNA-processing protein TSR2 homolog | Homo | <M><A><G><A><A><E><D><A><R><A><L><F><R><A><G><V><C><A><A><L><E><A><W><P><A><L><Q><I><A><V><E><N><G><F><G><G><V><H><S><Q><E><K><A><K><W><L><G><G><A><V><E><D><Y><F><M><R><N><A><D><L><E><L><D><E><V><E><D><F><L><G><E><L><L><T><N><E><F><D><T><V><V><E><D><G><S><L><P><Q><V><S><Q><Q><L><Q><T><M><F><H><H><F><Q><R><G><D><G><A><A><L><R><E><M><A><S><C><I><T><Q><R><K><C><K><V><T><A><T><A><L><K><T><A><R><E><T><D><E><D><E><D><D><V><D><S><V><E><E><M><E><V><T><A><T><N><D><G><A><A><T><D><G><V><C><P><Q><P><E><P><S><D><P><D><A><Q><T><I><K><E><E><D><I><V><E><D><G><W><T><I><V><R><R><K><K> | May be involved in 20S pre-rRNA processing.<BOP> | Q969E8 |
P50053 | KHK_HUMAN | Hepatic fructokinase | Homo | <M><E><E><K><Q><I><L><C><V><G><L><V><V><L><D><V><I><S><L><V><D><K><Y><P><K><E><D><S><E><I><R><C><L><S><Q><R><W><Q><R><G><G><N><A><S><N><S><C><T><V><L><S><L><L><G><A><P><C><A><F><M><G><S><M><A><P><G><H><V><A><D><F><L><V><A><D><F><R><R><R><G><V><D><V><S><Q><V><A><W><Q><S><K><G><D><T><P><S><S><C><C><I><I><N><N><S><N><G><N><R><T><I><V><L><H><D><T><S><L><P><D><V><S><A><T><D><F><E><K><V><D><L><T><Q><F><K><W><I><H><I><E><G><R><N><A><S><E><Q><V><K><M><L><Q><R><I><D><A><H><N><T><R><Q><P><P><E><Q><K><I><R><V><S><V><E><V><E><K><P><R><E><E><L><F><Q><L><F><G><Y><G><D><V><V><F><V><S><K><D><V><A><K><H><L><G><F><Q><S><A><E><E><A><L><R><G><L><Y><G><R><V><R><K><G><A><V><L><V><C><A><W><A><E><E><G><A><D><A><L><G><P><D><G><K><L><L><H><S><D><A><F><P><P><P><R><V><V><D><T><L><G><A><G><D><T><F><N><A><S><V><I><F><S><L><S><Q><G><R><S><V><Q><E><A><L><R><F><G><C><Q><V><A><G><K><K><C><G><L><Q><G><F><D><G><I><V> | Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.<BOP> | P50053 |
Q9H2C2 | ARV1_HUMAN | Protein ARV1 | Homo | <M><G><N><G><G><R><S><G><L><Q><Q><G><K><G><N><V><D><G><V><A><A><T><P><T><A><A><S><A><S><C><Q><Y><R><C><I><E><C><N><Q><E><A><K><E><L><Y><R><D><Y><N><H><G><V><L><K><I><T><I><C><K><S><C><Q><K><P><V><D><K><Y><I><E><Y><D><P><V><I><I><L><I><N><A><I><L><C><K><A><Q><A><Y><R><H><I><L><F><N><T><Q><I><N><I><H><G><K><L><C><I><F><C><L><L><C><E><A><Y><L><R><W><W><Q><L><Q><D><S><N><Q><N><T><A><P><D><D><L><I><R><Y><A><K><E><W><D><F><Y><R><M><F><A><I><A><A><L><E><Q><T><A><Y><F><I><G><I><F><T><F><L><W><V><E><R><P><M><T><A><K><K><K><P><N><F><I><L><L><L><K><A><L><L><L><S><S><Y><G><K><L><L><L><I><P><A><V><I><W><E><H><D><Y><T><S><V><C><L><K><L><I><K><V><F><V><L><T><S><N><F><Q><A><I><R><V><T><L><N><I><N><R><K><L><S><F><L><A><V><L><S><G><L><L><L><E><S><I><M><V><Y><F><F><Q><S><M><E><W><D><V><G><S><D><Y><A><I><F><K><S><Q><D><F> | Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis . Participates in sterol transport out of the ER and distribution into plasma membranes .<BOP> | Q9H2C2 |
P13521 | SCG2_HUMAN | Manserin | Homo | <M><A><E><A><K><T><H><W><L><G><A><A><L><S><L><I><P><L><I><F><L><I><S><G><A><E><A><A><S><F><Q><R><N><Q><L><L><Q><K><E><P><D><L><R><L><E><N><V><Q><K><F><P><S><P><E><M><I><R><A><L><E><Y><I><E><N><L><R><Q><Q><A><H><K><E><E><S><S><P><D><Y><N><P><Y><Q><G><V><S><V><P><L><Q><Q><K><E><N><G><D><E><S><H><L><P><E><R><D><S><L><S><E><E><D><W><M><R><I><I><L><E><A><L><R><Q><A><E><N><E><P><Q><S><A><P><K><E><N><K><P><Y><A><L><N><S><E><K><N><F><P><M><D><M><S><D><D><Y><E><T><Q><Q><W><P><E><R><K><L><K><H><M><Q><F><P><P><M><Y><E><E><N><S><R><D><N><P><F><K><R><T><N><E><I><V><E><E><Q><Y><T><P><Q><S><L><A><T><L><E><S><V><F><Q><E><L><G><K><L><T><G><P><N><N><Q><K><R><E><R><M><D><E><E><Q><K><L><Y><T><D><D><E><D><D><I><Y><K><A><N><N><I><A><Y><E><D><V><V><G><G><E><D><W><N><P><V><E><E><K><I><E><S><Q><T><Q><E><E><V><R><D><S><K><E><N><I><E><K><N><E><Q><I><N><D><E><M><K><R><S><G><Q><L><G><I><Q><E><E><D><L><R><K><E><S><K><D><Q><L><S><D><D><V><S><K><V><I><A><Y><L><K><R><L><V><N><A><A><G><S><G><R><L><Q><N><G><Q><N><G><E><R><A><T><R><L><F><E><K><P><L><D><S><Q><S><I><Y><Q><L><I><E><I><S><R><N><L><Q><I><P><P><E><D><L><I><E><M><L><K><T><G><E><K><P><N><G><S><V><E><P><E><R><E><L><D><L><P><V><D><L><D><D><I><S><E><A><D><L><D><H><P><D><L><F><Q><N><R><M><L><S><K><S><G><Y><P><K><T><P><G><R><A><G><T><E><A><L><P><D><G><L><S><V><E><D><I><L><N><L><L><G><M><E><S><A><A><N><Q><K><T><S><Y><F><P><N><P><Y><N><Q><E><K><V><L><P><R><L><P><Y><G><A><G><R><S><R><S><N><Q><L><P><K><A><A><W><I><P><H><V><E><N><R><Q><M><A><Y><E><N><L><N><D><K><D><Q><E><L><G><E><Y><L><A><R><M><L><V><K><Y><P><E><I><I><N><S><N><Q><V><K><R><V><P><G><Q><G><S><S><E><D><D><L><Q><E><E><E><Q><I><E><Q><A><I><K><E><H><L><N><Q><G><S><S><Q><E><T><D><K><L><A><P><V><S><K><R><F><P><V><G><P><P><K><N><D><D><T><P><N><R><Q><Y><W><D><E><D><L><L><M><K><V><L><E><Y><L><N><Q><E><K><A><E><K><G><R><E><H><I><A><K><R><A><M><E><N><M> | Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.<BOP> | P13521 |
P52298 | NCBP2_HUMAN | NCBP-interacting protein 1 | Homo | <M><S><G><G><L><L><K><A><L><R><S><D><S><Y><V><E><L><S><Q><Y><R><D><Q><H><F><R><G><D><N><E><E><Q><E><K><L><L><K><K><S><C><T><L><Y><V><G><N><L><S><F><Y><T><T><E><E><Q><I><Y><E><L><F><S><K><S><G><D><I><K><K><I><I><M><G><L><D><K><M><K><K><T><A><C><G><F><C><F><V><E><Y><Y><S><R><A><D><A><E><N><A><M><R><Y><I><N><G><T><R><L><D><D><R><I><I><R><T><D><W><D><A><G><F><K><E><G><R><Q><Y><G><R><G><R><S><G><G><Q><V><R><D><E><Y><R><Q><D><Y><D><A><G><R><G><G><Y><G><K><L><A><Q><N><Q> | Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least | P52298 |
Q99616 | CCL13_HUMAN | C-C motif chemokine 13, short chain | Homo | <M><K><V><S><A><V><L><L><C><L><L><L><M><T><A><A><F><N><P><Q><G><L><A><Q><P><D><A><L><N><V><P><S><T><C><C><F><T><F><S><S><K><K><I><S><L><Q><R><L><K><S><Y><V><I><T><T><S><R><C><P><Q><K><A><V><I><F><R><T><K><L><G><K><E><I><C><A><D><P><K><E><K><W><V><Q><N><Y><M><K><H><L><G><R><K><A><H><T><L><K><T> | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.<BOP> | Q99616 |
Q6NUM9 | RETST_HUMAN | PPAR-alpha-regulated and starvation-induced gene protein | Homo | <M><W><L><P><L><V><L><L><L><A><V><L><L><L><A><V><L><C><K><V><Y><L><G><L><F><S><G><S><S><P><N><P><F><S><E><D><V><K><R><P><P><A><P><L><V><T><D><K><E><A><R><K><K><V><L><K><Q><A><F><S><A><N><Q><V><P><E><K><L><D><V><V><V><I><G><S><G><F><G><G><L><A><A><A><A><I><L><A><K><A><G><K><R><V><L><V><L><E><Q><H><T><K><A><G><G><C><C><H><T><F><G><K><N><G><L><E><F><D><T><G><I><H><Y><I><G><R><M><E><E><G><S><I><G><R><F><I><L><D><Q><I><T><E><G><Q><L><D><W><A><P><L><S><S><P><F><D><I><M><V><L><E><G><P><N><G><R><K><E><Y><P><M><Y><S><G><E><K><A><Y><I><Q><G><L><K><E><K><F><P><Q><E><E><A><I><I><D><K><Y><I><K><L><V><K><V><V><S><S><G><A><P><H><A><I><L><L><K><F><L><P><L><P><V><V><Q><L><L><D><R><C><G><L><L><T><R><F><S><P><F><L><Q><A><S><T><Q><S><L><A><E><V><L><Q><Q><L><G><A><S><S><E><L><Q><A><V><L><S><Y><I><F><P><T><Y><G><V><T><P><N><H><S><A><F><S><M><H><A><L><L><V><N><H><Y><M><K><G><G><F><Y><P><R><G><G><S><S><E><I><A><F><H><T><I><P><V><I><Q><R><A><G><G><A><V><L><T><K><A><T><V><Q><S><V><L><L><D><S><A><G><K><A><C><G><V><S><V><K><K><G><H><E><L><V><N><I><Y><C><P><I><V><V><S><N><A><G><L><F><N><T><Y><E><H><L><L><P><G><N><A><R><C><L><P><G><V><K><Q><Q><L><G><T><V><R><P><G><L><G><M><T><S><V><F><I><C><L><R><G><T><K><E><D><L><H><L><P><S><T><N><Y><Y><V><Y><Y><D><T><D><M><D><Q><A><M><E><R><Y><V><S><M><P><R><E><E><A><A><E><H><I><P><L><L><F><F><A><F><P><S><A><K><D><P><T><W><E><D><R><F><P><G><R><S><T><M><I><M><L><I><P><T><A><Y><E><W><F><E><E><W><Q><A><E><L><K><G><K><R><G><S><D><Y><E><T><F><K><N><S><F><V><E><A><S><M><S><V><V><L><K><L><F><P><Q><L><E><G><K><V><E><S><V><T><A><G><S><P><L><T><N><Q><F><Y><L><A><A><P><R><G><A><C><Y><G><A><D><H><D><L><G><R><L><H><P><C><V><M><A><S><L><R><A><Q><S><P><I><P><N><L><Y><L><T><G><Q><D><I><F><T><C><G><L><V><G><A><L><Q><G><A><L><L><C><S><S><A><I><L><K><R><N><L><Y><S><D><L><K><N><L><D><S><R><I><R><A><Q><K><K><K><N> | Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.<BOP> | Q6NUM9 |
Q9BQ95 | ECSIT_HUMAN | Protein SITPEC | Homo | <M><S><W><V><Q><A><T><L><L><A><R><G><L><C><R><A><W><G><G><T><C><G><A><A><L><T><G><T><S><I><S><Q><V><P><R><R><L><P><R><G><L><H><C><S><A><A><A><H><S><S><E><Q><S><L><V><P><S><P><P><E><P><R><Q><R><P><T><K><A><L><V><P><F><E><D><L><F><G><Q><A><P><G><G><E><R><D><K><A><S><F><L><Q><T><V><Q><K><F><A><E><H><S><V><R><K><R><G><H><I><D><F><I><Y><L><A><L><R><K><M><R><E><Y><G><V><E><R><D><L><A><V><Y><N><Q><L><L><N><I><F><P><K><E><V><F><R><P><R><N><I><I><Q><R><I><F><V><H><Y><P><R><Q><Q><E><C><G><I><A><V><L><E><Q><M><E><N><H><G><V><M><P><N><K><E><T><E><F><L><L><I><Q><I><F><G><R><K><S><Y><P><M><L><K><L><V><R><L><K><L><W><F><P><R><F><M><N><V><N><P><F><P><V><P><R><D><L><P><Q><D><P><V><E><L><A><M><F><G><L><R><H><M><E><P><D><L><S><A><R><V><T><I><Y><Q><V><P><L><P><K><D><S><T><G><A><A><D><P><P><Q><P><H><I><V><G><I><Q><S><P><D><Q><Q><A><A><L><A><R><H><N><P><A><R><P><V><F><V><E><G><P><F><S><L><W><L><R><N><K><C><V><Y><Y><H><I><L><R><A><D><L><L><P><P><E><E><R><E><V><E><E><T><P><E><E><W><N><L><Y><Y><P><M><Q><L><D><L><E><Y><V><R><S><G><W><D><N><Y><E><F><D><I><N><E><V><E><E><G><P><V><F><A><M><C><M><A><G><A><H><D><Q><A><T><M><A><K><W><I><Q><G><L><Q><E><T><N><P><T><L><A><Q><I><P><V><V><F><R><L><A><G><S><T><R><E><L><Q><T><S><S><A><G><L><E><E><P><P><L><P><E><D><H><Q><E><E><D><D><N><L><Q><R><Q><Q><Q><G><Q><S> | As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.<BOP> | Q9BQ95 |
Q15777 | MPPD2_HUMAN | Metallophosphoesterase domain-containing protein 2 | Homo | <M><A><H><G><I><P><S><Q><G><K><V><T><I><T><V><D><E><Y><S><S><N><P><T><Q><A><F><T><H><Y><N><I><N><Q><S><R><F><Q><P><P><H><V><H><M><V><D><P><I><P><Y><D><T><P><K><P><A><G><H><T><R><F><V><C><I><S><D><T><H><S><R><T><D><G><I><Q><M><P><Y><G><D><I><L><L><H><T><G><D><F><T><E><L><G><L><P><S><E><V><K><K><F><N><D><W><L><G><N><L><P><Y><E><Y><K><I><V><I><A><G><N><H><E><L><T><F><D><K><E><F><M><A><D><L><V><K><Q><D><Y><Y><R><F><P><S><V><S><K><L><K><P><E><D><F><D><N><V><Q><S><L><L><T><N><S><I><Y><L><Q><D><S><E><V><T><V><K><G><F><R><I><Y><G><A><P><W><T><P><W><F><N><G><W><G><F><N><L><P><R><G><Q><S><L><L><D><K><W><N><L><I><P><E><G><I><D><I><L><M><T><H><G><P><P><L><G><F><R><D><W><V><P><K><E><L><Q><R><V><G><C><V><E><L><L><N><T><V><Q><R><R><V><R><P><K><L><H><V><F><G><G><I><H><E><G><Y><G><I><M><T><D><G><Y><T><T><Y><I><N><A><S><T><C><T><V><S><F><Q><P><T><N><P><P><I><I><F><D><L><P><N><P><Q><G><S> | Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.<BOP> | Q15777 |
Q9Y294 | ASF1A_HUMAN | CCG1-interacting factor A | Homo | <M><A><K><V><Q><V><N><N><V><V><V><L><D><N><P><S><P><F><Y><N><P><F><Q><F><E><I><T><F><E><C><I><E><D><L><S><E><D><L><E><W><K><I><I><Y><V><G><S><A><E><S><E><E><Y><D><Q><V><L><D><S><V><L><V><G><P><V><P><A><G><R><H><M><F><V><F><Q><A><D><A><P><N><P><G><L><I><P><D><A><D><A><V><G><V><T><V><V><L><I><T><C><T><Y><R><G><Q><E><F><I><R><V><G><Y><Y><V><N><N><E><Y><T><E><T><E><L><R><E><N><P><P><V><K><P><D><F><S><K><L><Q><R><N><I><L><A><S><N><P><R><V><T><R><F><H><I><N><W><E><D><N><T><E><K><L><E><D><A><E><S><S><N><P><N><L><Q><S><L><L><S><T><D><A><L><P><S><A><S><K><G><W><S><T><S><E><N><S><L><N><V><M><L><E><S><H><M><D><C><M> | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly . Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly . Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51 . Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol . Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence | Q9Y294 |
Q9UJX3 | APC7_HUMAN | Cyclosome subunit 7 | Homo | <M><N><V><I><D><H><V><R><D><M><A><A><A><G><L><H><S><N><V><R><L><L><S><S><L><L><L><T><M><S><N><N><N><P><E><L><F><S><P><P><Q><K><Y><Q><L><L><V><Y><H><A><D><S><L><F><H><D><K><E><Y><R><N><A><V><S><K><Y><T><M><A><L><Q><Q><K><K><A><L><S><K><T><S><K><V><R><P><S><T><G><N><S><A><S><T><P><Q><S><Q><C><L><P><S><E><I><E><V><K><Y><K><M><A><E><C><Y><T><M><L><K><Q><D><K><D><A><I><A><I><L><D><G><I><P><S><R><Q><R><T><P><K><I><N><M><M><L><A><N><L><Y><K><K><A><G><Q><E><R><P><S><V><T><S><Y><K><E><V><L><R><Q><C><P><L><A><L><D><A><I><L><G><L><L><S><L><S><V><K><G><A><E><V><A><S><M><T><M><N><V><I><Q><T><V><P><N><L><D><W><L><S><V><W><I><K><A><Y><A><F><V><H><T><G><D><N><S><R><A><I><S><T><I><C><S><L><E><K><K><S><L><L><R><D><N><V><D><L><L><G><S><L><A><D><L><Y><F><R><A><G><D><N><K><N><S><V><L><K><F><E><Q><A><Q><M><L><D><P><Y><L><I><K><G><M><D><V><Y><G><Y><L><L><A><R><E><G><R><L><E><D><V><E><N><L><G><C><R><L><F><N><I><S><D><Q><H><A><E><P><W><V><V><S><G><C><H><S><F><Y><S><K><R><Y><S><R><A><L><Y><L><G><A><K><A><I><Q><L><N><S><N><S><V><Q><A><L><L><L><K><G><A><A><L><R><N><M><G><R><V><Q><E><A><I><I><H><F><R><E><A><I><R><L><A><P><C><R><L><D><C><Y><E><G><L><I><E><C><Y><L><A><S><N><S><I><R><E><A><M><V><M><A><N><N><V><Y><K><T><L><G><A><N><A><Q><T><L><T><L><L><A><T><V><C><L><E><D><P><V><T><Q><E><K><A><K><T><L><L><D><K><A><L><T><Q><R><P><D><Y><I><K><A><V><V><K><K><A><E><L><L><S><R><E><Q><K><Y><E><D><G><I><A><L><L><R><N><A><L><A><N><Q><S><D><C><V><L><H><R><I><L><G><D><F><L><V><A><V><N><E><Y><Q><E><A><M><D><Q><Y><S><I><A><L><S><L><D><P><N><D><Q><K><S><L><E><G><M><Q><K><M><E><K><E><E><S><P><T><D><A><T><Q><E><E><D><V><D><D><M><E><G><S><G><E><E><G><D><L><E><G><S><D><S><E><A><A><Q><W><A><D><Q><E><Q><W><F><G><M><Q> | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<BOP> | Q9UJX3 |
Q9HBZ2 | ARNT2_HUMAN | Class E basic helix-loop-helix protein 1 | Homo | <M><A><T><P><A><A><V><N><P><P><E><M><A><S><D><I><P><G><S><V><T><L><P><V><A><P><M><A><A><T><G><Q><V><R><M><A><G><A><M><P><A><R><G><G><K><R><R><S><G><M><D><F><D><D><E><D><G><E><G><P><S><K><F><S><R><E><N><H><S><E><I><E><R><R><R><R><N><K><M><T><Q><Y><I><T><E><L><S><D><M><V><P><T><C><S><A><L><A><R><K><P><D><K><L><T><I><L><R><M><A><V><S><H><M><K><S><M><R><G><T><G><N><K><S><T><D><G><A><Y><K><P><S><F><L><T><E><Q><E><L><K><H><L><I><L><E><A><A><D><G><F><L><F><V><V><A><A><E><T><G><R><V><I><Y><V><S><D><S><V><T><P><V><L><N><Q><P><Q><S><E><W><F><G><S><T><L><Y><E><Q><V><H><P><D><D><V><E><K><L><R><E><Q><L><C><T><S><E><N><S><M><T><G><R><I><L><D><L><K><T><G><T><V><K><K><E><G><Q><Q><S><S><M><R><M><C><M><G><S><R><R><S><F><I><C><R><M><R><C><G><N><A><P><L><D><H><L><P><L><N><R><I><T><T><M><R><K><R><F><R><N><G><L><G><P><V><K><E><G><E><A><Q><Y><A><V><V><H><C><T><G><Y><I><K><A><W><P><P><A><G><M><T><I><P><E><E><D><A><D><V><G><Q><G><S><K><Y><C><L><V><A><I><G><R><L><Q><V><T><S><S><P><V><C><M><D><M><N><G><M><S><V><P><T><E><F><L><S><R><H><N><S><D><G><I><I><T><F><V><D><P><R><C><I><S><V><I><G><Y><Q><P><Q><D><L><L><G><K><D><I><L><E><F><C><H><P><E><D><Q><S><H><L><R><E><S><F><Q><Q><V><V><K><L><K><G><Q><V><L><S><V><M><Y><R><F><R><T><K><N><R><E><W><M><L><I><R><T><S><S><F><T><F><Q><N><P><Y><S><D><E><I><E><Y><I><I><C><T><N><T><N><V><K><Q><L><Q><Q><Q><Q><A><E><L><E><V><H><Q><R><D><G><L><S><S><Y><D><L><S><Q><V><P><V><P><N><L><P><A><G><V><H><E><A><G><K><S><V><E><K><A><D><A><I><F><S><Q><E><R><D><P><R><F><A><E><M><F><A><G><I><S><A><S><E><K><K><M><M><S><S><A><S><A><A><G><T><Q><Q><I><Y><S><Q><G><S><P><F><P><S><G><H><S><G><K><A><F><S><S><S><V><V><H><V><P><G><V><N><D><I><Q><S><S><S><S><T><G><Q><N><M><S><Q><I><S><R><Q><L><N><Q><S><Q><V><A><W><T><G><S><R><P><P><F><P><G><Q><Q><I><P><S><Q><S><S><K><T><Q><S><S><P><F><G><I><G><T><S><H><T><Y><P><A><D><P><S><S><Y><S><P><L><S><S><P><A><T><S><S><P><S><G><N><A><Y><S><S><L><A><N><R><T><P><G><F><A><E><S><G><Q><S><S><G><Q><F><Q><G><R><P><S><E><V><W><S><Q><W><Q><S><Q><H><H><G><Q><Q><S><G><E><Q><H><S><H><Q><Q><P><G><Q><T><E><V><F><Q><D><M><L><P><M><P><G><D><P><T><Q><G><T><G><N><Y><N><I><E><D><F><A><D><L><G><M><F><P><P><F><S><E> | Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function . Specifically recognizes the xenobiotic response element (XRE).<BOP> | Q9HBZ2 |
Q9Y3A6 | TMED5_HUMAN | p28 | Homo | <M><G><D><K><I><W><L><P><F><P><V><L><L><L><A><A><L><P><P><V><L><L><P><G><A><A><G><F><T><P><S><L><D><S><D><F><T><F><T><L><P><A><G><Q><K><E><C><F><Y><Q><P><M><P><L><K><A><S><L><E><I><E><Y><Q><V><L><D><G><A><G><L><D><I><D><F><H><L><A><S><P><E><G><K><T><L><V><F><E><Q><R><K><S><D><G><V><H><T><V><E><T><E><V><G><D><Y><M><F><C><F><D><N><T><F><S><T><I><S><E><K><V><I><F><F><E><L><I><L><D><N><M><G><E><Q><A><Q><E><Q><E><D><W><K><K><Y><I><T><G><T><D><I><L><D><M><K><L><E><D><I><L><E><S><I><N><S><I><K><S><R><L><S><K><S><G><H><I><Q><T><L><L><R><A><F><E><A><R><D><R><N><I><Q><E><S><N><F><D><R><V><N><F><W><S><M><V><N><L><V><V><M><V><V><V><S><A><I><Q><V><Y><M><L><K><S><L><F><E><D><K><R><K><S><R><T> | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.<BOP> | Q9Y3A6 |
Q9BQB6 | VKOR1_HUMAN | Vitamin K1 2,3-epoxide reductase subunit 1 | Homo | <M><G><S><T><W><G><S><P><G><W><V><R><L><A><L><C><L><T><G><L><V><L><S><L><Y><A><L><H><V><K><A><A><R><A><R><D><R><D><Y><R><A><L><C><D><V><G><T><A><I><S><C><S><R><V><F><S><S><R><W><G><R><G><F><G><L><V><E><H><V><L><G><Q><D><S><I><L><N><Q><S><N><S><I><F><G><C><I><F><Y><T><L><Q><L><L><L><G><C><L><R><T><R><W><A><S><V><L><M><L><L><S><S><L><V><S><L><A><G><S><V><Y><L><A><W><I><L><F><F><V><L><Y><D><F><C><I><V><C><I><T><T><Y><A><I><N><V><S><L><M><W><L><S><F><R><K><V><Q><E><P><Q><G><K><A><K><R><H> | Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.<BOP> | Q9BQB6 |
O95497 | VNN1_HUMAN | Vascular non-inflammatory molecule 1 | Homo | <M><T><T><Q><L><P><A><Y><V><A><I><L><L><F><Y><V><S><R><A><S><C><Q><D><T><F><T><A><A><V><Y><E><H><A><A><I><L><P><N><A><T><L><T><P><V><S><R><E><E><A><L><A><L><M><N><R><N><L><D><I><L><E><G><A><I><T><S><A><A><D><Q><G><A><H><I><I><V><T><P><E><D><A><I><Y><G><W><N><F><N><R><D><S><L><Y><P><Y><L><E><D><I><P><D><P><E><V><N><W><I><P><C><N><N><R><N><R><F><G><Q><T><P><V><Q><E><R><L><S><C><L><A><K><N><N><S><I><Y><V><V><A><N><I><G><D><K><K><P><C><D><T><S><D><P><Q><C><P><P><D><G><R><Y><Q><Y><N><T><D><V><V><F><D><S><Q><G><K><L><V><A><R><Y><H><K><Q><N><L><F><M><G><E><N><Q><F><N><V><P><K><E><P><E><I><V><T><F><N><T><T><F><G><S><F><G><I><F><T><C><F><D><I><L><F><H><D><P><A><V><T><L><V><K><D><F><H><V><D><T><I><V><F><P><T><A><W><M><N><V><L><P><H><L><S><A><V><E><F><H><S><A><W><A><M><G><M><R><V><N><F><L><A><S><N><I><H><Y><P><S><K><K><M><T><G><S><G><I><Y><A><P><N><S><S><R><A><F><H><Y><D><M><K><T><E><E><G><K><L><L><L><S><Q><L><D><S><H><P><S><H><S><A><V><V><N><W><T><S><Y><A><S><S><I><E><A><L><S><S><G><N><K><E><F><K><G><T><V><F><F><D><E><F><T><F><V><K><L><T><G><V><A><G><N><Y><T><V><C><Q><K><D><L><C><C><H><L><S><Y><K><M><S><E><N><I><P><N><E><V><Y><A><L><G><A><F><D><G><L><H><T><V><E><G><R><Y><Y><L><Q><I><C><T><L><L><K><C><K><T><T><N><L><N><T><C><G><D><S><A><E><T><A><S><T><R><F><E><M><F><S><L><S><G><T><F><G><T><Q><Y><V><F><P><E><V><L><L><S><E><N><Q><L><A><P><G><E><F><Q><V><S><T><D><G><R><L><F><S><L><K><P><T><S><G><P><V><L><T><V><T><L><F><G><R><L><Y><E><K><D><W><A><S><N><A><S><S><G><L><T><A><Q><A><R><I><I><M><L><I><V><I><A><P><I><V><C><S><L><S><W> | Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.<BOP> | O95497 |
P13797 | PLST_HUMAN | T-plastin | Homo | <M><D><E><M><A><T><T><Q><I><S><K><D><E><L><D><E><L><K><E><A><F><A><K><V><D><L><N><S><N><G><F><I><C><D><Y><E><L><H><E><L><F><K><E><A><N><M><P><L><P><G><Y><K><V><R><E><I><I><Q><K><L><M><L><D><G><D><R><N><K><D><G><K><I><S><F><D><E><F><V><Y><I><F><Q><E><V><K><S><S><D><I><A><K><T><F><R><K><A><I><N><R><K><E><G><I><C><A><L><G><G><T><S><E><L><S><S><E><G><T><Q><H><S><Y><S><E><E><E><K><Y><A><F><V><N><W><I><N><K><A><L><E><N><D><P><D><C><R><H><V><I><P><M><N><P><N><T><D><D><L><F><K><A><V><G><D><G><I><V><L><C><K><M><I><N><L><S><V><P><D><T><I><D><E><R><A><I><N><K><K><K><L><T><P><F><I><I><Q><E><N><L><N><L><A><L><N><S><A><S><A><I><G><C><H><V><V><N><I><G><A><E><D><L><R><A><G><K><P><H><L><V><L><G><L><L><W><Q><I><I><K><I><G><L><F><A><D><I><E><L><S><R><N><E><A><L><A><A><L><L><R><D><G><E><T><L><E><E><L><M><K><L><S><P><E><E><L><L><L><R><W><A><N><F><H><L><E><N><S><G><W><Q><K><I><N><N><F><S><A><D><I><K><D><S><K><A><Y><F><H><L><L><N><Q><I><A><P><K><G><Q><K><E><G><E><P><R><I><D><I><N><M><S><G><F><N><E><T><D><D><L><K><R><A><E><S><M><L><Q><Q><A><D><K><L><G><C><R><Q><F><V><T><P><A><D><V><V><S><G><N><P><K><L><N><L><A><F><V><A><N><L><F><N><K><Y><P><A><L><T><K><P><E><N><Q><D><I><D><W><T><L><L><E><G><E><T><R><E><E><R><T><F><R><N><W><M><N><S><L><G><V><N><P><H><V><N><H><L><Y><A><D><L><Q><D><A><L><V><I><L><Q><L><Y><E><R><I><K><V><P><V><D><W><S><K><V><N><K><P><P><Y><P><K><L><G><A><N><M><K><K><L><E><N><C><N><Y><A><V><E><L><G><K><H><P><A><K><F><S><L><V><G><I><G><G><Q><D><L><N><D><G><N><Q><T><L><T><L><A><L><V><W><Q><L><M><R><R><Y><T><L><N><V><L><E><D><L><G><D><G><Q><K><A><N><D><D><I><I><V><N><W><V><N><R><T><L><S><E><A><G><K><S><T><S><I><Q><S><F><K><D><K><T><I><S><S><S><L><A><V><V><D><L><I><D><A><I><Q><P><G><C><I><N><Y><D><L><V><K><S><G><N><L><T><E><D><D><K><H><N><N><A><K><Y><A><V><S><M><A><R><R><I><G><A><R><V><Y><A><L><P><E><D><L><V><E><V><K><P><K><M><V><M><T><V><F><A><C><L><M><G><R><G><M><K><R><V> | Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.<BOP> | P13797 |
P40198 | CEAM3_HUMAN | Carcinoembryonic antigen CGM1 | Homo | <M><G><P><P><S><A><S><P><H><R><E><C><I><P><W><Q><G><L><L><L><T><A><S><L><L><N><F><W><N><P><P><T><T><A><K><L><T><I><E><S><M><P><L><S><V><A><E><G><K><E><V><L><L><L><V><H><N><L><P><Q><H><L><F><G><Y><S><W><Y><K><G><E><R><V><D><G><N><S><L><I><V><G><Y><V><I><G><T><Q><Q><A><T><P><G><A><A><Y><S><G><R><E><T><I><Y><T><N><A><S><L><L><I><Q><N><V><T><Q><N><D><I><G><F><Y><T><L><Q><V><I><K><S><D><L><V><N><E><E><A><T><G><Q><F><H><V><Y><Q><E><N><A><P><G><L><P><V><G><A><V><A><G><I><V><T><G><V><L><V><G><V><A><L><V><A><A><L><V><C><F><L><L><L><A><K><T><G><R><T><S><I><Q><R><D><L><K><E><Q><Q><P><Q><A><L><A><P><G><R><G><P><S><H><S><S><A><F><S><M><S><P><L><S><T><A><Q><A><P><L><P><N><P><R><T><A><A><S><I><Y><E><E><L><L><K><H><D><T><N><I><Y><C><R><M><D><H><K><A><E><V><A><S> | Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.<BOP> | P40198 |
O14975 | S27A2_HUMAN | Very long-chain-fatty-acid-CoA ligase | Homo | <M><L><S><A><I><Y><T><V><L><A><G><L><L><F><L><P><L><L><V><N><L><C><C><P><Y><F><F><Q><D><I><G><Y><F><L><K><V><A><A><V><G><R><R><V><R><S><Y><G><K><R><R><P><A><R><T><I><L><R><A><F><L><E><K><A><R><Q><T><P><H><K><P><F><L><L><F><R><D><E><T><L><T><Y><A><Q><V><D><R><R><S><N><Q><V><A><R><A><L><H><D><H><L><G><L><R><Q><G><D><C><V><A><L><L><M><G><N><E><P><A><Y><V><W><L><W><L><G><L><V><K><L><G><C><A><M><A><C><L><N><Y><N><I><R><A><K><S><L><L><H><C><F><Q><C><C><G><A><K><V><L><L><V><S><P><E><L><Q><A><A><V><E><E><I><L><P><S><L><K><K><D><D><V><S><I><Y><Y><V><S><R><T><S><N><T><D><G><I><D><S><F><L><D><K><V><D><E><V><S><T><E><P><I><P><E><S><W><R><S><E><V><T><F><S><T><P><A><L><Y><I><Y><T><S><G><T><T><G><L><P><K><A><A><M><I><T><H><Q><R><I><W><Y><G><T><G><L><T><F><V><S><G><L><K><A><D><D><V><I><Y><I><T><L><P><F><Y><H><S><A><A><L><L><I><G><I><H><G><C><I><V><A><G><A><T><L><A><L><R><T><K><F><S><A><S><Q><F><W><D><D><C><R><K><Y><N><V><T><V><I><Q><Y><I><G><E><L><L><R><Y><L><C><N><S><P><Q><K><P><N><D><R><D><H><K><V><R><L><A><L><G><N><G><L><R><G><D><V><W><R><Q><F><V><K><R><F><G><D><I><C><I><Y><E><F><Y><A><A><T><E><G><N><I><G><F><M><N><Y><A><R><K><V><G><A><V><G><R><V><N><Y><L><Q><K><K><I><I><T><Y><D><L><I><K><Y><D><V><E><K><D><E><P><V><R><D><E><N><G><Y><C><V><R><V><P><K><G><E><V><G><L><L><V><C><K><I><T><Q><L><T><P><F><N><G><Y><A><G><A><K><A><Q><T><E><K><K><K><L><R><D><V><F><K><K><G><D><L><Y><F><N><S><G><D><L><L><M><V><D><H><E><N><F><I><Y><F><H><D><R><V><G><D><T><F><R><W><K><G><E><N><V><A><T><T><E><V><A><D><T><V><G><L><V><D><F><V><Q><E><V><N><V><Y><G><V><H><V><P><D><H><E><G><R><I><G><M><A><S><I><K><M><K><E><N><H><E><F><D><G><K><K><L><F><Q><H><I><A><D><Y><L><P><S><Y><A><R><P><R><F><L><R><I><Q><D><T><I><E><I><T><G><T><F><K><H><R><K><M><T><L><V><E><E><G><F><N><P><A><V><I><K><D><A><L><Y><F><L><D><D><T><A><K><M><Y><V><P><M><T><E><D><I><Y><N><A><I><S><A><K><T><L><K><L> | Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.<BOP> | O14975 |
Q96Q11 | TRNT1_HUMAN | mt tRNA adenylyltransferase | Homo | <M><L><R><C><L><Y><H><W><H><R><P><V><L><N><R><R><W><S><R><L><C><L><P><K><Q><Y><L><F><T><M><K><L><Q><S><P><E><F><Q><S><L><F><T><E><G><L><K><S><L><T><E><L><F><V><K><E><N><H><E><L><R><I><A><G><G><A><V><R><D><L><L><N><G><V><K><P><Q><D><I><D><F><A><T><T><A><T><P><T><Q><M><K><E><M><F><Q><S><A><G><I><R><M><I><N><N><R><G><E><K><H><G><T><I><T><A><R><L><H><E><E><N><F><E><I><T><T><L><R><I><D><V><T><T><D><G><R><H><A><E><V><E><F><T><T><D><W><Q><K><D><A><E><R><R><D><L><T><I><N><S><M><F><L><G><F><D><G><T><L><F><D><Y><F><N><G><Y><E><D><L><K><N><K><K><V><R><F><V><G><H><A><K><Q><R><I><Q><E><D><Y><L><R><I><L><R><Y><F><R><F><Y><G><R><I><V><D><K><P><G><D><H><D><P><E><T><L><E><A><I><A><E><N><A><K><G><L><A><G><I><S><G><E><R><I><W><V><E><L><K><K><I><L><V><G><N><H><V><N><H><L><I><H><L><I><Y><D><L><D><V><A><P><Y><I><G><L><P><A><N><A><S><L><E><E><F><D><K><V><S><K><N><V><D><G><F><S><P><K><P><V><T><L><L><A><S><L><F><K><V><Q><D><D><V><T><K><L><D><L><R><L><K><I><A><K><E><E><K><N><L><G><L><F><I><V><K><N><R><K><D><L><I><K><A><T><D><S><S><D><P><L><K><P><Y><Q><D><F><I><I><D><S><R><E><P><D><A><T><T><R><V><C><E><L><L><K><Y><Q><G><E><H><C><L><L><K><E><M><Q><Q><W><S><I><P><P><F><P><V><S><G><H><D><I><R><K><V><G><I><S><S><G><K><E><I><G><A><L><L><Q><Q><L><R><E><Q><W><K><K><S><G><Y><Q><M><E><K><D><E><L><L><S><Y><I><K><K><T> | Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).<BOP> | Q96Q11 |
Q9NR50 | EI2BG_HUMAN | eIF-2B GDP-GTP exchange factor subunit gamma | Homo | <M><E><F><Q><A><V><V><M><A><V><G><G><G><S><R><M><T><D><L><T><S><S><I><P><K><P><L><L><P><V><G><N><K><P><L><I><W><Y><P><L><N><L><L><E><R><V><G><F><E><E><V><I><V><V><T><T><R><D><V><Q><K><A><L><C><A><E><F><K><M><K><M><K><P><D><I><V><C><I><P><D><D><A><D><M><G><T><A><D><S><L><R><Y><I><Y><P><K><L><K><T><D><V><L><V><L><S><C><D><L><I><T><D><V><A><L><H><E><V><V><D><L><F><R><A><Y><D><A><S><L><A><M><L><M><R><K><G><Q><D><S><I><E><P><V><P><G><Q><K><G><K><K><K><A><V><E><Q><R><D><F><I><G><V><D><S><T><G><K><R><L><L><F><M><A><N><E><A><D><L><D><E><E><L><V><I><K><G><S><I><L><Q><K><H><P><R><I><R><F><H><T><G><L><V><D><A><H><L><Y><C><L><K><K><Y><I><V><D><F><L><M><E><N><G><S><I><T><S><I><R><S><E><L><I><P><Y><L><V><R><K><Q><F><S><S><A><S><S><Q><Q><G><Q><E><E><K><E><E><D><L><K><K><K><E><L><K><S><L><D><I><Y><S><F><I><K><E><A><N><T><L><N><L><A><P><Y><D><A><C><W><N><A><C><R><G><D><R><W><E><D><L><S><R><S><Q><V><R><C><Y><V><H><I><M><K><E><G><L><C><S><R><V><S><T><L><G><L><Y><M><E><A><N><R><Q><V><P><K><L><L><S><A><L><C><P><E><E><P><P><V><H><S><S><A><Q><I><V><S><K><H><L><V><G><V><D><S><L><I><G><P><E><T><Q><I><G><E><K><S><S><I><K><R><S><V><I><G><S><S><C><L><I><K><D><R><V><T><I><T><N><C><L><L><M><N><S><V><T><V><E><E><G><S><N><I><Q><G><S><V><I><C><N><N><A><V><I><E><K><G><A><D><I><K><D><C><L><I><G><S><G><Q><R><I><E><A><K><A><K><R><V><N><E><V><I><V><G><N><D><Q><L><M><E><I> | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.<BOP> | Q9NR50 |
P0DSO2 | SCGR9_HUMAN | Keratin-associated protein 28-1 pseudogene | Homo | <M><G><C><C><G><C><G><S><C><G><C><S><G><G><C><G><G><G><C><G><G><G><C><G><G><G><C><G><S><C><T><T><C><R><C><Y><R><V><G><C><C><S><S><C><C><P><C><C><R><G><C><C><G><G><C><C><S><T><P><V><I><C><C><C><R><R><T><C><S><S><C><G><C><G><C><G><K><G><C><C><Q><Q><K><S><C><C><Q><K><Q><C><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | P0DSO2 |
Q16515 | ASIC2_HUMAN | Mammalian degenerin homolog | Homo | <M><D><L><K><E><S><P><S><E><G><S><L><Q><P><S><S><I><Q><I><F><A><N><T><S><T><L><H><G><I><R><H><I><F><V><Y><G><P><L><T><I><R><R><V><L><W><A><V><A><F><V><G><S><L><G><L><L><L><V><E><S><S><E><R><V><S><Y><Y><F><S><Y><Q><H><V><T><K><V><D><E><V><V><A><Q><S><L><V><F><P><A><V><T><L><C><N><L><N><G><F><R><F><S><R><L><T><T><N><D><L><Y><H><A><G><E><L><L><A><L><L><D><V><N><L><Q><I><P><D><P><H><L><A><D><P><S><V><L><E><A><L><R><Q><K><A><N><F><K><H><Y><K><P><K><Q><F><S><M><L><E><F><L><H><R><V><G><H><D><L><K><D><M><M><L><Y><C><K><F><K><G><Q><E><C><G><H><Q><D><F><T><T><V><F><T><K><Y><G><K><C><Y><M><F><N><S><G><E><D><G><K><P><L><L><T><T><V><K><G><G><T><G><N><G><L><E><I><M><L><D><I><Q><Q><D><E><Y><L><P><I><W><G><E><T><E><E><T><T><F><E><A><G><V><K><V><Q><I><H><S><Q><S><E><P><P><F><I><Q><E><L><G><F><G><V><A><P><G><F><Q><T><F><V><A><T><Q><E><Q><R><L><T><Y><L><P><P><P><W><G><E><C><R><S><S><E><M><G><L><D><F><F><P><V><Y><S><I><T><A><C><R><I><D><C><E><T><R><Y><I><V><E><N><C><N><C><R><M><V><H><M><P><G><D><A><P><F><C><T><P><E><Q><H><K><E><C><A><E><P><A><L><G><L><L><A><E><K><D><S><N><Y><C><L><C><R><T><P><C><N><L><T><R><Y><N><K><E><L><S><M><V><K><I><P><S><K><T><S><A><K><Y><L><E><K><K><F><N><K><S><E><K><Y><I><S><E><N><I><L><V><L><D><I><F><F><E><A><L><N><Y><E><T><I><E><Q><K><K><A><Y><E><V><A><A><L><L><G><D><I><G><G><Q><M><G><L><F><I><G><A><S><I><L><T><I><L><E><L><F><D><Y><I><Y><E><L><I><K><E><K><L><L><D><L><L><G><K><E><E><D><E><G><S><H><D><E><N><V><S><T><C><D><T><M><P><N><H><S><E><T><I><S><H><T><V><N><V><P><L><Q><T><T><L><G><T><L><E><E><I><A><C> | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.<BOP> | Q16515 |
Q9BRQ4 | CF300_HUMAN | Cilia- and flagella-associated protein 300 | Homo | <M><A><T><G><E><L><G><D><L><G><G><Y><Y><F><R><F><L><P><Q><K><T><F><Q><S><L><S><S><K><E><I><T><S><R><L><R><Q><W><S><M><L><G><R><I><K><A><Q><A><F><G><F><D><Q><T><F><Q><S><Y><R><K><D><D><F><V><M><A><F><F><K><D><P><N><V><I><P><N><L><K><L><L><S><D><S><S><G><Q><W><I><I><L><G><T><E><V><K><K><I><E><A><I><N><V><P><C><T><Q><L><S><M><S><F><F><H><R><L><Y><D><E><D><I><V><R><D><S><G><H><I><V><K><C><L><D><S><F><C><D><P><F><L><I><S><D><E><L><R><R><V><L><L><V><E><D><S><E><K><Y><E><I><F><S><Q><P><D><R><E><E><F><L><F><C><L><F><K><H><L><C><L><G><G><A><L><C><Q><Y><E><D><V><I><S><P><Y><L><E><T><T><K><L><I><Y><K><D><L><V><S><V><R><K><N><P><Q><T><K><K><I><Q><I><T><S><S><V><F><K><V><S><A><Y><D><S><A><G><M><C><Y><P><S><A><K><N><H><E><Q><T><F><S><Y><F><I><V><D><P><I><R><R><H><L><H><V><L><Y><H><C><Y><G><V><G><D><M><S> | Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.<BOP> | Q9BRQ4 |
Q9HAV5 | TNR27_HUMAN | X-linked ectodysplasin-A2 receptor | Homo | <M><D><C><Q><E><N><E><Y><W><D><Q><W><G><R><C><V><T><C><Q><R><C><G><P><G><Q><E><L><S><K><D><C><G><Y><G><E><G><G><D><A><Y><C><T><A><C><P><P><R><R><Y><K><S><S><W><G><H><H><R><C><Q><S><C><I><T><C><A><V><I><N><R><V><Q><K><V><N><C><T><A><T><S><N><A><V><C><G><D><C><L><P><R><F><Y><R><K><T><R><I><G><G><L><Q><D><Q><E><C><I><P><C><T><K><Q><T><P><T><S><E><V><Q><C><A><F><Q><L><S><L><V><E><A><D><T><P><T><V><P><P><Q><E><A><T><L><V><A><L><V><S><S><L><L><V><V><F><T><L><A><F><L><G><L><F><F><L><Y><C><K><Q><F><F><N><R><H><C><Q><R><G><G><L><L><Q><F><E><A><D><K><T><A><K><E><E><S><L><F><P><V><P><P><S><K><E><T><S><A><E><S><Q><V><S><E><N><I><F><Q><T><Q><P><L><N><P><I><L><E><D><D><C><S><S><T><S><G><F><P><T><Q><E><S><F><T><M><A><S><C><T><S><E><S><H><S><H><W><V><H><S><P><I><E><C><T><E><L><D><L><Q><K><F><S><S><S><A><S><Y><T><G><A><E><T><L><G><G><N><T><V><E><S><T><G><D><R><L><E><L><N><V><P><F><E><V><P><S><P> | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.<BOP> | Q9HAV5 |
Q9BXS9 | S26A6_HUMAN | Pendrin-like protein 1 | Homo | <M><G><L><A><D><A><S><G><P><R><D><T><Q><A><L><L><S><A><T><Q><A><M><D><L><R><R><R><D><Y><H><M><E><R><P><L><L><N><Q><E><H><L><E><E><L><G><R><W><G><S><A><P><R><T><H><Q><W><R><T><W><L><Q><C><S><R><A><R><A><Y><A><L><L><L><Q><H><L><P><V><L><V><W><L><P><R><Y><P><V><R><D><W><L><L><G><D><L><L><S><G><L><S><V><A><I><M><Q><L><P><Q><G><L><A><Y><A><L><L><A><G><L><P><P><V><F><G><L><Y><S><S><F><Y><P><V><F><I><Y><F><L><F><G><T><S><R><H><I><S><V><G><T><F><A><V><M><S><V><M><V><G><S><V><T><E><S><L><A><P><Q><A><L><N><D><S><M><I><N><E><T><A><R><D><A><A><R><V><Q><V><A><S><T><L><S><V><L><V><G><L><F><Q><V><G><L><G><L><I><H><F><G><F><V><V><T><Y><L><S><E><P><L><V><R><G><Y><T><T><A><A><A><V><Q><V><F><V><S><Q><L><K><Y><V><F><G><L><H><L><S><S><H><S><G><P><L><S><L><I><Y><T><V><L><E><V><C><W><K><L><P><Q><S><K><V><G><T><V><V><T><A><A><V><A><G><V><V><L><V><V><V><K><L><L><N><D><K><L><Q><Q><Q><L><P><M><P><I><P><G><E><L><L><T><L><I><G><A><T><G><I><S><Y><G><M><G><L><K><H><R><F><E><V><D><V><V><G><N><I><P><A><G><L><V><P><P><V><A><P><N><T><Q><L><F><S><K><L><V><G><S><A><F><T><I><A><V><V><G><F><A><I><A><I><S><L><G><K><I><F><A><L><R><H><G><Y><R><V><D><S><N><Q><E><L><V><A><L><G><L><S><N><L><I><G><G><I><F><Q><C><F><P><V><S><C><S><M><S><R><S><L><V><Q><E><S><T><G><G><N><S><Q><V><A><G><A><I><S><S><L><F><I><L><L><I><I><V><K><L><G><E><L><F><H><D><L><P><K><A><V><L><A><A><I><I><I><V><N><L><K><G><M><L><R><Q><L><S><D><M><R><S><L><W><K><A><N><R><A><D><L><L><I><W><L><V><T><F><T><A><T><I><L><L><N><L><D><L><G><L><V><V><A><V><I><F><S><L><L><L><V><V><V><R><T><Q><M><P><H><Y><S><V><L><G><Q><V><P><D><T><D><I><Y><R><D><V><A><E><Y><S><E><A><K><E><V><R><G><V><K><V><F><R><S><S><A><T><V><Y><F><A><N><A><E><F><Y><S><D><A><L><K><Q><R><C><G><V><D><V><D><F><L><I><S><Q><K><K><K><L><L><K><K><Q><E><Q><L><K><L><K><Q><L><Q><K><E><E><K><L><R><K><Q><A><A><S><P><K><G><A><S><V><S><I><N><V><N><T><S><L><E><D><M><R><S><N><N><V><E><D><C><K><M><M><Q><V><S><S><G><D><K><M><E><D><A><T><A><N><G><Q><E><D><S><K><A><P><D><G><S><T><L><K><A><L><G><L><P><Q><P><D><F><H><S><L><I><L><D><L><G><A><L><S><F><V><D><T><V><C><L><K><S><L><K><N><I><F><H><D><F><R><E><I><E><V><E><V><Y><M><A><A><C><H><S><P><V><V><S><Q><L><E><A><G><H><F><F><D><A><S><I><T><K><K><H><L><F><A><S><V><H><D><A><V><T><F><A><L><Q><H><P><R><P><V><P><D><S><P><V><S><V><T><R><L> | Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.<BOP> | Q9BXS9 |
Q13114 | TRAF3_HUMAN | RING-type E3 ubiquitin transferase TRAF3 | Homo | <M><E><S><S><K><K><M><D><S><P><G><A><L><Q><T><N><P><P><L><K><L><H><T><D><R><S><A><G><T><P><V><F><V><P><E><Q><G><G><Y><K><E><K><F><V><K><T><V><E><D><K><Y><K><C><E><K><C><H><L><V><L><C><S><P><K><Q><T><E><C><G><H><R><F><C><E><S><C><M><A><A><L><L><S><S><S><S><P><K><C><T><A><C><Q><E><S><I><V><K><D><K><V><F><K><D><N><C><C><K><R><E><I><L><A><L><Q><I><Y><C><R><N><E><S><R><G><C><A><E><Q><L><M><L><G><H><L><L><V><H><L><K><N><D><C><H><F><E><E><L><P><C><V><R><P><D><C><K><E><K><V><L><R><K><D><L><R><D><H><V><E><K><A><C><K><Y><R><E><A><T><C><S><H><C><K><S><Q><V><P><M><I><A><L><Q><K><H><E><D><T><D><C><P><C><V><V><V><S><C><P><H><K><C><S><V><Q><T><L><L><R><S><E><L><S><A><H><L><S><E><C><V><N><A><P><S><T><C><S><F><K><R><Y><G><C><V><F><Q><G><T><N><Q><Q><I><K><A><H><E><A><S><S><A><V><Q><H><V><N><L><L><K><E><W><S><N><S><L><E><K><K><V><S><L><L><Q><N><E><S><V><E><K><N><K><S><I><Q><S><L><H><N><Q><I><C><S><F><E><I><E><I><E><R><Q><K><E><M><L><R><N><N><E><S><K><I><L><H><L><Q><R><V><I><D><S><Q><A><E><K><L><K><E><L><D><K><E><I><R><P><F><R><Q><N><W><E><E><A><D><S><M><K><S><S><V><E><S><L><Q><N><R><V><T><E><L><E><S><V><D><K><S><A><G><Q><V><A><R><N><T><G><L><L><E><S><Q><L><S><R><H><D><Q><M><L><S><V><H><D><I><R><L><A><D><M><D><L><R><F><Q><V><L><E><T><A><S><Y><N><G><V><L><I><W><K><I><R><D><Y><K><R><R><K><Q><E><A><V><M><G><K><T><L><S><L><Y><S><Q><P><F><Y><T><G><Y><F><G><Y><K><M><C><A><R><V><Y><L><N><G><D><G><M><G><K><G><T><H><L><S><L><F><F><V><I><M><R><G><E><Y><D><A><L><L><P><W><P><F><K><Q><K><V><T><L><M><L><M><D><Q><G><S><S><R><R><H><L><G><D><A><F><K><P><D><P><N><S><S><S><F><K><K><P><T><G><E><M><N><I><A><S><G><C><P><V><F><V><A><Q><T><V><L><E><N><G><T><Y><I><K><D><D><T><I><F><I><K><V><I><V><D><T><S><D><L><P><D><P> | Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types . In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome . Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance . Acts also as a constitutive negative regulator of the alternative NF-kappa | Q13114 |
Q96S59 | RANB9_HUMAN | RanBP7 | Homo | <M><S><G><Q><P><P><P><P><P><P><Q><Q><Q><Q><Q><Q><Q><Q><L><S><P><P><P><P><A><A><L><A><P><V><S><G><V><V><L><P><A><P><P><A><V><S><A><G><S><S><P><A><G><S><P><G><G><G><A><G><G><E><G><L><G><A><A><A><A><A><L><L><L><H><P><P><P><P><P><P><P><A><T><A><A><P><P><P><P><P><P><P><P><P><P><P><A><S><A><A><A><P><A><S><G><P><P><A><P><P><G><L><A><A><G><P><G><P><A><G><G><A><P><T><P><A><L><V><A><G><S><S><A><A><A><P><F><P><H><G><D><S><A><L><N><E><Q><E><K><E><L><Q><R><R><L><K><R><L><Y><P><A><V><D><E><Q><E><T><P><L><P><R><S><W><S><P><K><D><K><F><S><Y><I><G><L><S><Q><N><N><L><R><V><H><Y><K><G><H><G><K><T><P><K><D><A><A><S><V><R><A><T><H><P><I><P><A><A><C><G><I><Y><Y><F><E><V><K><I><V><S><K><G><R><D><G><Y><M><G><I><G><L><S><A><Q><G><V><N><M><N><R><L><P><G><W><D><K><H><S><Y><G><Y><H><G><D><D><G><H><S><F><C><S><S><G><T><G><Q><P><Y><G><P><T><F><T><T><G><D><V><I><G><C><C><V><N><L><I><N><N><T><C><F><Y><T><K><N><G><H><S><L><G><I><A><F><T><D><L><P><P><N><L><Y><P><T><V><G><L><Q><T><P><G><E><V><V><D><A><N><F><G><Q><H><P><F><V><F><D><I><E><D><Y><M><R><E><W><R><T><K><I><Q><A><Q><I><D><R><F><P><I><G><D><R><E><G><E><W><Q><T><M><I><Q><K><M><V><S><S><Y><L><V><H><H><G><Y><C><A><T><A><E><A><F><A><R><S><T><D><Q><T><V><L><E><E><L><A><S><I><K><N><R><Q><R><I><Q><K><L><V><L><A><G><R><M><G><E><A><I><E><T><T><Q><Q><L><Y><P><S><L><L><E><R><N><P><N><L><L><F><T><L><K><V><R><Q><F><I><E><M><V><N><G><T><D><S><E><V><R><C><L><G><G><R><S><P><K><S><Q><D><S><Y><P><V><S><P><R><P><F><S><S><P><S><M><S><P><S><H><G><M><N><I><H><N><L><A><S><G><K><G><S><T><A><H><F><S><G><F><E><S><C><S><N><G><V><I><S><N><K><A><H><Q><S><Y><C><H><S><N><K><H><Q><S><S><N><L><N><V><P><E><L><N><S><I><N><M><S><R><S><Q><Q><V><N><N><F><T><S><N><D><V><D><M><E><T><D><H><Y><S><N><G><V><G><E><T><S><S><N><G><F><L><N><G><S><S><K><H><D><H><E><M><E><D><C><D><T><E><M><E><V><D><S><S><Q><L><R><R><Q><L><C><G><G><S><Q><A><A><I><E><R><M><I><H><F><G><R><E><L><Q><A><M><S><E><Q><L><R><R><D><C><G><K><N><T><A><N><K><K><M><L><K><D><A><F><S><L><L><A><Y><S><D><P><W><N><S><P><V><G><N><Q><L><D><P><I><Q><R><E><P><V><C><S><A><L><N><S><A><I><L><E><T><H><N><L><P><K><Q><P><P><L><A><L><A><M><G><Q><A><T><Q><C><L><G><L><M><A><R><S><G><I><G><S><C><A><F><A><T><V><E><D><Y><L><H> | May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement . Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . May be involved in signaling of ITGB2/LFA-1 and other integrins . Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway . Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation . Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity . Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.<BOP> | Q96S59 |
P23610 | HAP40_HUMAN | Factor VIII intron 22 protein | Homo | <M><A><A><A><A><A><G><L><G><G><G><G><A><G><P><G><P><E><A><G><D><F><L><A><R><Y><R><L><V><S><N><K><L><K><K><R><F><L><R><K><P><N><V><A><E><A><G><E><Q><F><G><Q><L><G><R><E><L><R><A><Q><E><C><L><P><Y><A><A><W><C><Q><L><A><V><A><R><C><Q><Q><A><L><F><H><G><P><G><E><A><L><A><L><T><E><A><A><R><L><F><L><R><Q><E><R><D><A><R><Q><R><L><V><C><P><A><A><Y><G><E><P><L><Q><A><A><A><S><A><L><G><A><A><V><R><L><H><L><E><L><G><Q><P><A><A><A><A><A><L><C><L><E><L><A><A><A><L><R><D><L><G><Q><P><A><A><A><A><G><H><F><Q><R><A><A><Q><L><Q><L><P><Q><L><P><L><A><A><L><Q><A><L><G><E><A><A><S><C><Q><L><L><A><R><D><Y><T><G><A><L><A><V><F><T><R><M><Q><R><L><A><R><E><H><G><S><H><P><V><Q><S><L><P><P><P><P><P><P><A><P><Q><P><G><P><G><A><T><P><A><L><P><A><A><L><L><P><P><N><S><G><S><A><A><P><S><P><A><A><L><G><A><F><S><D><V><L><V><R><C><E><V><S><R><V><L><L><L><L><L><L><Q><P><P><P><A><K><L><L><P><E><H><A><Q><T><L><E><K><Y><S><W><E><A><F><D><S><H><G><Q><E><S><S><G><Q><L><P><E><E><L><F><L><L><L><Q><S><L><V><M><A><T><H><E><K><D><T><E><A><I><K><S><L><Q><V><E><M><W><P><L><L><T><A><E><Q><N><H><L><L><H><L><V><L><Q><E><T><I><S><P><S><G><Q><G><V> | RAB5A effector molecule that is involved in vesicular trafficking of early endosomes . Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility .<BOP> | P23610 |
P28702 | RXRB_HUMAN | Retinoid X receptor beta | Homo | <M><S><W><A><A><R><P><P><F><L><P><Q><R><H><A><A><G><Q><C><G><P><V><G><V><R><K><E><M><H><C><G><V><A><S><R><W><R><R><R><R><P><W><L><D><P><A><A><A><A><A><A><A><V><A><G><G><E><Q><Q><T><P><E><P><E><P><G><E><A><G><R><D><G><M><G><D><S><G><R><D><S><R><S><P><D><S><S><S><P><N><P><L><P><Q><G><V><P><P><P><S><P><P><G><P><P><L><P><P><S><T><A><P><S><L><G><G><S><G><A><P><P><P><P><P><M><P><P><P><P><L><G><S><P><F><P><V><I><S><S><S><M><G><S><P><G><L><P><P><P><A><P><P><G><F><S><G><P><V><S><S><P><Q><I><N><S><T><V><S><L><P><G><G><G><S><G><P><P><E><D><V><K><P><P><V><L><G><V><R><G><L><H><C><P><P><P><P><G><G><P><G><A><G><K><R><L><C><A><I><C><G><D><R><S><S><G><K><H><Y><G><V><Y><S><C><E><G><C><K><G><F><F><K><R><T><I><R><K><D><L><T><Y><S><C><R><D><N><K><D><C><T><V><D><K><R><Q><R><N><R><C><Q><Y><C><R><Y><Q><K><C><L><A><T><G><M><K><R><E><A><V><Q><E><E><R><Q><R><G><K><D><K><D><G><D><G><E><G><A><G><G><A><P><E><E><M><P><V><D><R><I><L><E><A><E><L><A><V><E><Q><K><S><D><Q><G><V><E><G><P><G><G><T><G><G><S><G><S><S><P><N><D><P><V><T><N><I><C><Q><A><A><D><K><Q><L><F><T><L><V><E><W><A><K><R><I><P><H><F><S><S><L><P><L><D><D><Q><V><I><L><L><R><A><G><W><N><E><L><L><I><A><S><F><S><H><R><S><I><D><V><R><D><G><I><L><L><A><T><G><L><H><V><H><R><N><S><A><H><S><A><G><V><G><A><I><F><D><R><V><L><T><E><L><V><S><K><M><R><D><M><R><M><D><K><T><E><L><G><C><L><R><A><I><I><L><F><N><P><D><A><K><G><L><S><N><P><S><E><V><E><V><L><R><E><K><V><Y><A><S><L><E><T><Y><C><K><Q><K><Y><P><E><Q><Q><G><R><F><A><K><L><L><L><R><L><P><A><L><R><S><I><G><L><K><C><L><E><H><L><F><F><F><K><L><I><G><D><T><P><I><D><T><F><L><M><E><M><L><E><A><P><H><Q><L><A> | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).<BOP> | P28702 |
A0A075B6J1 | LV537_HUMAN | Immunoglobulin lambda variable 5-37 | Homo | <M><A><W><T><P><L><L><L><L><L><L><S><H><C><T><G><S><L><S><Q><P><V><L><T><Q><P><P><S><S><S><A><S><P><G><E><S><A><R><L><T><C><T><L><P><S><D><I><N><V><G><S><Y><N><I><Y><W><Y><Q><Q><K><P><G><S><P><P><R><Y><L><L><Y><Y><Y><S><D><S><D><K><G><Q><G><S><G><V><P><S><R><F><S><G><S><K><D><A><S><A><N><T><G><I><L><L><I><S><G><L><Q><S><E><D><E><A><D><Y><Y><C><M><I><W><P><S><N><A><S> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A075B6J1 |
Q8IUK5 | PLDX1_HUMAN | Tumor endothelial marker 7 | Homo | <M><R><G><E><L><W><L><L><V><L><V><L><R><E><A><A><R><A><L><S><P><Q><P><G><A><G><H><D><E><G><P><G><S><G><W><A><A><K><G><T><V><R><G><W><N><R><R><A><R><E><S><P><G><H><V><S><E><P><D><R><T><Q><L><S><Q><D><L><G><G><G><T><L><A><M><D><T><L><P><D><N><R><T><R><V><V><E><D><N><H><S><Y><Y><V><S><R><L><Y><G><P><S><E><P><H><S><R><E><L><W><V><D><V><A><E><A><N><R><S><Q><V><K><I><H><T><I><L><S><N><T><H><R><Q><A><S><R><V><V><L><S><F><D><F><P><F><Y><G><H><P><L><R><Q><I><T><I><A><T><G><G><F><I><F><M><G><D><V><I><H><R><M><L><T><A><T><Q><Y><V><A><P><L><M><A><N><F><N><P><G><Y><S><D><N><S><T><V><V><Y><F><D><N><G><T><V><F><V><V><Q><W><D><H><V><Y><L><Q><G><W><E><D><K><G><S><F><T><F><Q><A><A><L><H><H><D><G><R><I><V><F><A><Y><K><E><I><P><M><S><V><P><E><I><S><S><S><Q><H><P><V><K><T><G><L><S><D><A><F><M><I><L><N><P><S><P><D><V><P><E><S><R><R><R><S><I><F><E><Y><H><R><I><E><L><D><P><S><K><V><T><S><M><S><A><V><E><F><T><P><L><P><T><C><L><Q><H><R><S><C><D><A><C><M><S><S><D><L><T><F><N><C><S><W><C><H><V><L><Q><R><C><S><S><G><F><D><R><Y><R><Q><E><W><M><D><Y><G><C><A><Q><E><A><E><G><R><M><C><E><D><F><Q><D><E><D><H><D><S><A><S><P><D><T><S><F><S><P><Y><D><G><D><L><T><T><T><S><S><S><L><F><I><D><S><L><T><T><E><D><D><T><K><L><N><P><Y><A><G><G><D><G><L><Q><N><N><L><S><P><K><T><K><G><T><P><V><H><L><G><T><I><V><G><I><V><L><A><V><L><L><V><A><A><I><I><L><A><G><I><Y><I><N><G><H><P><T><S><N><A><A><L><F><F><I><E><R><R><P><H><H><W><P><A><M><K><F><R><S><H><P><D><H><S><T><Y><A><E><V><E><P><S><G><H><E><K><E><G><F><M><E><A><E><Q><C> | Plays a critical role in endothelial cell capillary morphogenesis.<BOP> | Q8IUK5 |
Q9NRC1 | ST7_HUMAN | Protein HELG | Homo | <M><A><E><A><A><T><G><F><L><E><Q><L><K><S><C><I><V><W><S><W><T><Y><L><W><T><V><W><F><F><I><V><L><F><L><V><Y><I><L><R><V><P><L><K><I><N><D><N><L><S><T><V><S><M><F><L><N><T><L><T><P><K><F><Y><V><A><L><T><G><T><S><S><L><I><S><G><L><I><L><I><F><E><W><W><Y><F><R><K><Y><G><T><S><F><I><E><Q><V><S><V><S><H><L><R><P><L><L><G><G><V><D><N><N><S><S><N><N><S><N><S><S><N><G><D><S><D><S><N><R><Q><S><V><S><E><C><K><V><W><R><N><P><L><N><L><F><R><G><A><E><Y><N><R><Y><T><W><V><T><G><R><E><P><L><T><Y><Y><D><M><N><L><S><A><Q><D><H><Q><T><F><F><T><C><D><S><D><H><L><R><P><A><D><A><I><M><Q><K><A><W><R><E><R><N><P><Q><A><R><I><S><A><A><H><E><A><L><E><I><N><E><I><R><S><R><V><E><V><P><L><I><A><S><S><T><I><W><E><I><K><L><L><P><K><C><A><T><A><Y><I><L><L><A><E><E><E><A><T><T><I><A><E><A><E><K><L><F><K><Q><A><L><K><A><G><D><G><C><Y><R><R><S><Q><Q><L><Q><H><H><G><S><Q><Y><E><A><Q><H><R><R><D><T><N><V><L><V><Y><I><K><R><R><L><A><M><C><A><R><R><L><G><R><T><R><E><A><V><K><M><M><R><D><L><M><K><E><F><P><L><L><S><M><F><N><I><H><E><N><L><L><E><A><L><L><E><L><Q><A><Y><A><D><V><Q><A><V><L><A><K><Y><D><D><I><S><L><P><K><S><A><T><I><C><Y><T><A><A><L><L><K><A><R><A><V><S><D><K><F><S><P><E><A><A><S><R><R><G><L><S><T><A><E><M><N><A><V><E><A><I><H><R><A><V><E><F><N><P><H><V><P><K><Y><L><L><E><M><K><S><L><I><L><P><P><E><H><I><L><K><R><G><D><S><E><A><I><A><Y><A><F><F><H><L><A><H><W><K><R><V><E><G><A><L><N><L><L><H><C><T><W><E><G><T><F><R><M><I><P><Y><P><L><E><K><G><H><L><F><Y><P><Y><P><I><C><T><E><T><A><D><R><E><L><L><P><S><F><H><E><V><S><V><Y><P><K><K><E><L><P><F><F><I><L><F><T><A><G><L><C><S><F><T><A><M><L><A><L><L><T><H><Q><F><P><E><L><M><G><V><F><A><K><A><M><I><D><I><F><C><S><A><E><F><R><D><W><N><C><K><S><I><F><M><R><V><E><D><E><L><E><I><P><P><A><P><Q><S><Q><H><F><Q><N> | May act as a tumor suppressor.<BOP> | Q9NRC1 |
Q9NWQ8 | PHAG1_HUMAN | Transmembrane phosphoprotein Cbp | Homo | <M><G><P><A><G><S><L><L><G><S><G><Q><M><Q><I><T><L><W><G><S><L><A><A><V><A><I><F><F><V><I><T><F><L><I><F><L><C><S><S><C><D><R><E><K><K><P><R><Q><H><S><G><D><H><E><N><L><M><N><V><P><S><D><K><E><M><F><S><R><S><V><T><S><L><A><T><D><A><P><A><S><S><E><Q><N><G><A><L><T><N><G><D><I><L><S><E><D><S><T><L><T><C><M><Q><H><Y><E><E><V><Q><T><S><A><S><D><L><L><D><S><Q><D><S><T><G><K><P><K><C><H><Q><S><R><E><L><P><R><I><P><P><E><S><A><V><D><T><M><L><T><A><R><S><V><D><G><D><Q><G><L><G><M><E><G><P><Y><E><V><L><K><D><S><S><S><Q><E><N><M><V><E><D><C><L><Y><E><T><V><K><E><I><K><E><V><A><A><A><A><H><L><E><K><G><H><S><G><K><A><K><S><T><S><A><S><K><E><L><P><G><P><Q><T><E><G><K><A><E><F><A><E><Y><A><S><V><D><R><N><K><K><C><R><Q><S><V><N><V><E><S><I><L><G><N><S><C><D><P><E><E><E><A><P><P><P><V><P><V><K><L><L><D><E><N><E><N><L><Q><E><K><E><G><G><E><A><E><E><S><A><T><D><T><T><S><E><T><N><K><R><F><S><S><L><S><Y><K><S><R><E><E><D><P><T><L><T><E><E><E><I><S><A><M><Y><S><S><V><N><K><P><G><Q><L><V><N><K><S><G><Q><S><L><T><V><P><E><S><T><Y><T><S><I><Q><G><D><P><Q><R><S><P><S><S><C><N><D><L><Y><A><T><V><K><D><F><E><K><T><P><N><S><T><L><P><P><A><G><R><P><S><E><E><P><E><P><D><Y><E><A><I><Q><T><L><N><R><E><E><E><K><A><T><L><G><T><N><G><H><H><G><L><V><P><K><E><N><D><Y><E><S><I><S><D><L><Q><Q><G><R><D><I><T><R><L> | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.<BOP> | Q9NWQ8 |
P25815 | S100P_HUMAN | S100 calcium-binding protein P | Homo | <M><T><E><L><E><T><A><M><G><M><I><I><D><V><F><S><R><Y><S><G><S><E><G><S><T><Q><T><L><T><K><G><E><L><K><V><L><M><E><K><E><L><P><G><F><L><Q><S><G><K><D><K><D><A><V><D><K><L><L><K><D><L><D><A><N><G><D><A><Q><V><D><F><S><E><F><I><V><F><V><A><A><I><T><S><A><C><H><K><Y><F><E><K><A><G><L><K> | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).<BOP> | P25815 |
Q13825 | AUHM_HUMAN | Itaconyl-CoA hydratase | Homo | <M><A><A><A><V><A><A><A><P><G><A><L><G><S><L><H><A><G><G><A><R><L><V><A><A><C><S><A><W><L><C><P><G><L><R><L><P><G><S><L><A><G><R><R><A><G><P><A><I><W><A><Q><G><W><V><P><A><A><G><G><P><A><P><K><R><G><Y><S><S><E><M><K><T><E><D><E><L><R><V><R><H><L><E><E><E><N><R><G><I><V><V><L><G><I><N><R><A><Y><G><K><N><S><L><S><K><N><L><I><K><M><L><S><K><A><V><D><A><L><K><S><D><K><K><V><R><T><I><I><I><R><S><E><V><P><G><I><F><C><A><G><A><D><L><K><E><R><A><K><M><S><S><S><E><V><G><P><F><V><S><K><I><R><A><V><I><N><D><I><A><N><L><P><V><P><T><I><A><A><I><D><G><L><A><L><G><G><G><L><E><L><A><L><A><C><D><I><R><V><A><A><S><S><A><K><M><G><L><V><E><T><K><L><A><I><I><P><G><G><G><G><T><Q><R><L><P><R><A><I><G><M><S><L><A><K><E><L><I><F><S><A><R><V><L><D><G><K><E><A><K><A><V><G><L><I><S><H><V><L><E><Q><N><Q><E><G><D><A><A><Y><R><K><A><L><D><L><A><R><E><F><L><P><Q><G><P><V><A><M><R><V><A><K><L><A><I><N><Q><G><M><E><V><D><L><V><T><G><L><A><I><E><E><A><C><Y><A><Q><T><I><P><T><K><D><R><L><E><G><L><L><A><F><K><E><K><R><P><P><R><Y><K><G><E> | Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) . Can catalyze the reverse reaction but at a much lower rate in vitro . HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate . Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) . Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro . AREs direct rapid RNA degradation and mRNA deadenylation . Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramal | Q13825 |
P04040 | CATA_HUMAN | Catalase | Homo | <M><A><D><S><R><D><P><A><S><D><Q><M><Q><H><W><K><E><Q><R><A><A><Q><K><A><D><V><L><T><T><G><A><G><N><P><V><G><D><K><L><N><V><I><T><V><G><P><R><G><P><L><L><V><Q><D><V><V><F><T><D><E><M><A><H><F><D><R><E><R><I><P><E><R><V><V><H><A><K><G><A><G><A><F><G><Y><F><E><V><T><H><D><I><T><K><Y><S><K><A><K><V><F><E><H><I><G><K><K><T><P><I><A><V><R><F><S><T><V><A><G><E><S><G><S><A><D><T><V><R><D><P><R><G><F><A><V><K><F><Y><T><E><D><G><N><W><D><L><V><G><N><N><T><P><I><F><F><I><R><D><P><I><L><F><P><S><F><I><H><S><Q><K><R><N><P><Q><T><H><L><K><D><P><D><M><V><W><D><F><W><S><L><R><P><E><S><L><H><Q><V><S><F><L><F><S><D><R><G><I><P><D><G><H><R><H><M><N><G><Y><G><S><H><T><F><K><L><V><N><A><N><G><E><A><V><Y><C><K><F><H><Y><K><T><D><Q><G><I><K><N><L><S><V><E><D><A><A><R><L><S><Q><E><D><P><D><Y><G><I><R><D><L><F><N><A><I><A><T><G><K><Y><P><S><W><T><F><Y><I><Q><V><M><T><F><N><Q><A><E><T><F><P><F><N><P><F><D><L><T><K><V><W><P><H><K><D><Y><P><L><I><P><V><G><K><L><V><L><N><R><N><P><V><N><Y><F><A><E><V><E><Q><I><A><F><D><P><S><N><M><P><P><G><I><E><A><S><P><D><K><M><L><Q><G><R><L><F><A><Y><P><D><T><H><R><H><R><L><G><P><N><Y><L><H><I><P><V><N><C><P><Y><R><A><R><V><A><N><Y><Q><R><D><G><P><M><C><M><Q><D><N><Q><G><G><A><P><N><Y><Y><P><N><S><F><G><A><P><E><Q><Q><P><S><A><L><E><H><S><I><Q><Y><S><G><E><V><R><R><F><N><T><A><N><D><D><N><V><T><Q><V><R><A><F><Y><V><N><V><L><N><E><E><Q><R><K><R><L><C><E><N><I><A><G><H><L><K><D><A><Q><I><F><I><Q><K><K><A><V><K><N><F><T><E><V><H><P><D><Y><G><S><H><I><Q><A><L><L><D><K><Y><N><A><E><K><P><K><N><A><I><H><T><F><V><Q><S><G><S><H><L><A><A><R><E><K><A><N><L> | Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<BOP> | P04040 |
Q8NCB2 | CAMKV_HUMAN | CaM kinase-like vesicle-associated protein | Homo | <M><P><F><G><C><V><T><L><G><D><K><K><N><Y><N><Q><P><S><E><V><T><D><R><Y><D><L><G><Q><V><I><K><T><E><E><F><C><E><I><F><R><A><K><D><K><T><T><G><K><L><H><T><C><K><K><F><Q><K><R><D><G><R><K><V><R><K><A><A><K><N><E><I><G><I><L><K><M><V><K><H><P><N><I><L><Q><L><V><D><V><F><V><T><R><K><E><Y><F><I><F><L><E><L><A><T><G><R><E><V><F><D><W><I><L><D><Q><G><Y><Y><S><E><R><D><T><S><N><V><V><R><Q><V><L><E><A><V><A><Y><L><H><S><L><K><I><V><H><R><N><L><K><L><E><N><L><V><Y><Y><N><R><L><K><N><S><K><I><V><I><S><D><F><H><L><A><K><L><E><N><G><L><I><K><E><P><C><G><T><P><E><Y><L><A><P><E><V><V><G><R><Q><R><Y><G><R><P><V><D><C><W><A><I><G><V><I><M><Y><I><L><L><S><G><N><P><P><F><Y><E><E><V><E><E><D><D><Y><E><N><H><D><K><N><L><F><R><K><I><L><A><G><D><Y><E><F><D><S><P><Y><W><D><D><I><S><Q><A><A><K><D><L><V><T><R><L><M><E><V><E><Q><D><Q><R><I><T><A><E><E><A><I><S><H><E><W><I><S><G><N><A><A><S><D><K><N><I><K><D><G><V><C><A><Q><I><E><K><N><F><A><R><A><K><W><K><K><A><V><R><V><T><T><L><M><K><R><L><R><A><P><E><Q><S><S><T><A><A><A><Q><S><A><S><A><T><D><T><A><T><P><G><A><A><G><G><A><T><A><A><A><A><S><G><A><T><S><A><P><E><G><D><A><A><R><A><A><K><S><D><N><V><A><P><A><D><R><S><A><T><P><A><T><D><G><S><A><T><P><A><T><D><G><S><V><T><P><A><T><D><G><S><I><T><P><A><T><D><G><S><V><T><P><A><T><D><R><S><A><T><P><A><T><D><G><R><A><T><P><A><T><E><E><S><T><V><P><T><T><Q><S><S><A><M><L><A><T><K><A><A><A><T><P><E><P><A><M><A><Q><P><D><S><T><A><P><E><G><A><T><G><Q><A><P><P><S><S><K><G><E><E><A><A><G><Y><A><Q><E><S><Q><R><E><E><A><S> | Does not appear to have detectable kinase activity.<BOP> | Q8NCB2 |
P57739 | CLD2_HUMAN | SP82 | Homo | <M><A><S><L><G><L><Q><L><V><G><Y><I><L><G><L><L><G><L><L><G><T><L><V><A><M><L><L><P><S><W><K><T><S><S><Y><V><G><A><S><I><V><T><A><V><G><F><S><K><G><L><W><M><E><C><A><T><H><S><T><G><I><T><Q><C><D><I><Y><S><T><L><L><G><L><P><A><D><I><Q><A><A><Q><A><M><M><V><T><S><S><A><I><S><S><L><A><C><I><I><S><V><V><G><M><R><C><T><V><F><C><Q><E><S><R><A><K><D><R><V><A><V><A><G><G><V><F><F><I><L><G><G><L><L><G><F><I><P><V><A><W><N><L><H><G><I><L><R><D><F><Y><S><P><L><V><P><D><S><M><K><F><E><I><G><E><A><L><Y><L><G><I><I><S><S><L><F><S><L><I><A><G><I><I><L><C><F><S><C><S><S><Q><R><N><R><S><N><Y><Y><D><A><Y><Q><A><Q><P><L><A><T><R><S><S><P><R><P><G><Q><P><P><K><V><K><S><E><F><N><S><Y><S><L><T><G><Y><V> | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP> | P57739 |
Q96EZ8 | MCRS1_HUMAN | MCRS2 | Homo | <M><D><K><D><S><Q><G><L><L><D><S><S><L><M><A><S><G><T><A><S><R><S><E><D><E><E><S><L><A><G><Q><K><R><A><S><S><Q><A><L><G><T><I><P><K><R><R><S><S><S><R><F><I><K><R><K><K><F><D><D><E><L><V><E><S><S><L><A><K><S><S><T><R><A><K><G><A><S><G><V><E><P><G><R><C><S><G><S><E><P><S><S><S><E><K><K><K><V><S><K><A><P><S><T><P><V><P><P><S><P><A><P><A><P><G><L><T><K><R><V><K><K><S><K><Q><P><L><Q><V><T><K><D><L><G><R><W><K><P><A><D><D><L><L><L><I><N><A><V><L><Q><T><N><D><L><T><S><V><H><L><G><V><K><F><S><C><R><F><T><L><R><E><V><Q><E><R><W><Y><A><L><L><Y><D><P><V><I><S><K><L><A><C><Q><A><M><R><Q><L><H><P><E><A><I><A><A><I><Q><S><K><A><L><F><S><K><A><E><E><Q><L><L><S><K><V><G><S><T><S><Q><P><T><L><E><T><F><Q><D><L><L><H><R><H><P><D><A><F><Y><L><A><R><T><A><K><A><L><Q><A><H><W><Q><L><M><K><Q><Y><Y><L><L><E><D><Q><T><V><Q><P><L><P><K><G><D><Q><V><L><N><F><S><D><A><E><D><L><I><D><D><S><K><L><K><D><M><R><D><E><V><L><E><H><E><L><M><V><A><D><R><R><Q><K><R><E><I><R><Q><L><E><Q><E><L><H><K><W><Q><V><L><V><D><S><I><T><G><M><S><S><P><D><F><D><N><Q><T><L><A><V><L><R><G><R><M><V><R><Y><L><M><R><S><R><E><I><T><L><G><R><A><T><K><D><N><Q><I><D><V><D><L><S><L><E><G><P><A><W><K><I><S><R><K><Q><G><V><I><K><L><K><N><N><G><D><F><F><I><A><N><E><G><R><R><P><I><Y><I><D><G><R><P><V><L><C><G><S><K><W><R><L><S><N><N><S><V><V><E><I><A><S><L><R><F><V><F><L><I><N><Q><D><L><I><A><L><I><R><A><E><A><A><K><I><T><P><Q> | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity . Binds to G-quadruplex structures in mRNA . Binds to RNA homomer poly(G) and poly(U) .<BOP> | Q96EZ8 |
Q86X76 | NIT1_HUMAN | Nitrilase homolog 1 | Homo | <M><L><G><F><I><T><R><P><P><H><R><F><L><S><L><L><C><P><G><L><R><I><P><Q><L><S><V><L><C><A><Q><P><R><P><R><A><M><A><I><S><S><S><S><C><E><L><P><L><V><A><V><C><Q><V><T><S><T><P><D><K><Q><Q><N><F><K><T><C><A><E><L><V><R><E><A><A><R><L><G><A><C><L><A><F><L><P><E><A><F><D><F><I><A><R><D><P><A><E><T><L><H><L><S><E><P><L><G><G><K><L><L><E><E><Y><T><Q><L><A><R><E><C><G><L><W><L><S><L><G><G><F><H><E><R><G><Q><D><W><E><Q><T><Q><K><I><Y><N><C><H><V><L><L><N><S><K><G><A><V><V><A><T><Y><R><K><T><H><L><C><D><V><E><I><P><G><Q><G><P><M><C><E><S><N><S><T><M><P><G><P><S><L><E><S><P><V><S><T><P><A><G><K><I><G><L><A><V><C><Y><D><M><R><F><P><E><L><S><L><A><L><A><Q><A><G><A><E><I><L><T><Y><P><S><A><F><G><S><I><T><G><P><A><H><W><E><V><L><L><R><A><R><A><I><E><T><Q><C><Y><V><V><A><A><A><Q><C><G><R><H><H><E><K><R><A><S><Y><G><H><S><M><V><V><D><P><W><G><T><V><V><A><R><C><S><E><G><P><G><L><C><L><A><R><I><D><L><N><Y><L><R><Q><L><R><R><H><L><P><V><F><Q><H><R><R><P><D><L><Y><G><N><L><G><H><P><L><S> | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.<BOP> | Q86X76 |
Q8IV63 | VRK3_HUMAN | Vaccinia-related kinase 3 | Homo | <M><I><S><F><C><P><D><C><G><K><S><I><Q><A><A><F><K><F><C><P><Y><C><G><N><S><L><P><V><E><E><H><V><G><S><Q><T><F><V><N><P><H><V><S><S><F><Q><G><S><K><R><G><L><N><S><S><F><E><T><S><P><K><K><V><K><W><S><S><T><V><T><S><P><R><L><S><L><F><S><D><G><D><S><S><E><S><E><D><T><L><S><S><S><E><R><S><K><G><S><G><S><R><P><P><T><P><K><S><S><P><Q><K><T><R><K><S><P><Q><V><T><R><G><S><P><Q><K><T><S><C><S><P><Q><K><T><R><Q><S><P><Q><T><L><K><R><S><R><V><T><T><S><L><E><A><L><P><T><G><T><V><L><T><D><K><S><G><R><Q><W><K><L><K><S><F><Q><T><R><D><N><Q><G><I><L><Y><E><A><A><P><T><S><T><L><T><C><D><S><G><P><Q><K><Q><K><F><S><L><K><L><D><A><K><D><G><R><L><F><N><E><Q><N><F><F><Q><R><A><A><K><P><L><Q><V><N><K><W><K><K><L><Y><S><T><P><L><L><A><I><P><T><C><M><G><F><G><V><H><Q><D><K><Y><R><F><L><V><L><P><S><L><G><R><S><L><Q><S><A><L><D><V><S><P><K><H><V><L><S><E><R><S><V><L><Q><V><A><C><R><L><L><D><A><L><E><F><L><H><E><N><E><Y><V><H><G><N><V><T><A><E><N><I><F><V><D><P><E><D><Q><S><Q><V><T><L><A><G><Y><G><F><A><F><R><Y><C><P><S><G><K><H><V><A><Y><V><E><G><S><R><S><P><H><E><G><D><L><E><F><I><S><M><D><L><H><K><G><C><G><P><S><R><R><S><D><L><Q><S><L><G><Y><C><M><L><K><W><L><Y><G><F><L><P><W><T><N><C><L><P><N><T><E><D><I><M><K><Q><K><Q><K><F><V><D><K><P><G><P><F><V><G><P><C><G><H><W><I><R><P><S><E><T><L><Q><K><Y><L><K><V><V><M><A><L><T><Y><E><E><K><P><P><Y><A><M><L><R><N><N><L><E><A><L><L><Q><D><L><R><V><S><P><Y><D><P><I><G><L><P><M><V><P> | Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.<BOP> | Q8IV63 |
Q9BV10 | ALG12_HUMAN | Membrane protein SB87 | Homo | <M><A><G><K><G><S><S><G><R><R><P><L><L><L><G><L><L><V><A><V><A><T><V><H><L><V><I><C><P><Y><T><K><V><E><E><S><F><N><L><Q><A><T><H><D><L><L><Y><H><W><Q><D><L><E><Q><Y><D><H><L><E><F><P><G><V><V><P><R><T><F><L><G><P><V><V><I><A><V><F><S><S><P><A><V><Y><V><L><S><L><L><E><M><S><K><F><Y><S><Q><L><I><V><R><G><V><L><G><L><G><V><I><F><G><L><W><T><L><Q><K><E><V><R><R><H><F><G><A><M><V><A><T><M><F><C><W><V><T><A><M><Q><F><H><L><M><F><Y><C><T><R><T><L><P><N><V><L><A><L><P><V><V><L><L><A><L><A><A><W><L><R><H><E><W><A><R><F><I><W><L><S><A><F><A><I><I><V><F><R><V><E><L><C><L><F><L><G><L><L><L><L><L><A><L><G><N><R><K><V><S><V><V><R><A><L><R><H><A><V><P><A><G><I><L><C><L><G><L><T><V><A><V><D><S><Y><F><W><R><Q><L><T><W><P><E><G><K><V><L><W><Y><N><T><V><L><N><K><S><S><N><W><G><T><S><P><L><L><W><Y><F><Y><S><A><L><P><R><G><L><G><C><S><L><L><F><I><P><L><G><L><V><D><R><R><T><H><A><P><T><V><L><A><L><G><F><M><A><L><Y><S><L><L><P><H><K><E><L><R><F><I><I><Y><A><F><P><M><L><N><I><T><A><A><R><G><C><S><Y><L><L><N><N><Y><K><K><S><W><L><Y><K><A><G><S><L><L><V><I><G><H><L><V><V><N><A><A><Y><S><A><T><A><L><Y><V><S><H><F><N><Y><P><G><G><V><A><M><Q><R><L><H><Q><L><V><P><P><Q><T><D><V><L><L><H><I><D><V><A><A><A><Q><T><G><V><S><R><F><L><Q><V><N><S><A><W><R><Y><D><K><R><E><D><V><Q><P><G><T><G><M><L><A><Y><T><H><I><L><M><E><A><A><P><G><L><L><A><L><Y><R><D><T><H><R><V><L><A><S><V><V><G><T><T><G><V><S><L><N><L><T><Q><L><P><P><F><N><V><H><L><Q><T><K><L><V><L><L><E><R><L><P><R><P><S> | Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.<BOP> | Q9BV10 |
Q8WZ71 | TM158_HUMAN | Ras-induced senescence protein 1 | Homo | <M><L><P><L><L><A><A><L><L><A><A><A><C><P><L><P><P><V><R><G><G><A><A><D><A><P><G><L><L><G><V><P><S><N><A><S><V><N><A><S><S><A><D><E><P><I><A><P><R><L><L><A><S><A><A><P><G><P><P><E><R><P><G><P><E><E><A><A><A><A><A><A><P><C><N><I><S><V><Q><R><Q><M><L><S><S><L><L><V><R><W><G><R><P><R><G><F><Q><C><D><L><L><L><F><S><T><N><A><H><G><R><A><F><F><A><A><A><F><H><R><V><G><P><P><L><L><I><E><H><L><G><L><A><A><G><G><A><Q><Q><D><L><R><L><C><V><G><C><G><W><V><R><G><R><R><T><G><R><L><R><P><A><A><A><P><S><A><A><A><A><T><A><G><A><P><T><A><L><P><A><Y><P><A><A><E><P><P><G><P><L><W><L><Q><G><E><P><L><H><F><C><C><L><D><F><S><L><E><E><L><Q><G><E><P><G><W><R><L><N><R><K><P><I><E><S><T><L><V><A><C><F><M><T><L><V><I><V><V><W><S><V><A><A><L><I><W><P><V><P><I><I><A><G><F><L><P><N><G><M><E><Q><R><R><T><T><A><S><T><T><A><A><T><P><A><A><V><P><A><G><T><T><A><A><A><A><A><A><A><A><A><A><A><A><A><A><V><T><S><G><V><A><T><K> | Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.<BOP> | Q8WZ71 |
P61952 | GBG11_HUMAN | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | Homo | <M><P><A><L><H><I><E><D><L><P><E><K><E><K><L><K><M><E><V><E><Q><L><R><K><E><V><K><L><Q><R><Q><Q><V><S><K><C><S><E><E><I><K><N><Y><I><E><E><R><S><G><E><D><P><L><V><K><G><I><P><E><D><K><N><P><F><K><E><K><G><S><C><V><I><S> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP> | P61952 |
P07766 | CD3E_HUMAN | T-cell surface antigen T3/Leu-4 epsilon chain | Homo | <M><Q><S><G><T><H><W><R><V><L><G><L><C><L><L><S><V><G><V><W><G><Q><D><G><N><E><E><M><G><G><I><T><Q><T><P><Y><K><V><S><I><S><G><T><T><V><I><L><T><C><P><Q><Y><P><G><S><E><I><L><W><Q><H><N><D><K><N><I><G><G><D><E><D><D><K><N><I><G><S><D><E><D><H><L><S><L><K><E><F><S><E><L><E><Q><S><G><Y><Y><V><C><Y><P><R><G><S><K><P><E><D><A><N><F><Y><L><Y><L><R><A><R><V><C><E><N><C><M><E><M><D><V><M><S><V><A><T><I><V><I><V><D><I><C><I><T><G><G><L><L><L><L><V><Y><Y><W><S><K><N><R><K><A><K><A><K><P><V><T><R><G><A><G><A><G><G><R><Q><R><G><Q><N><K><E><R><P><P><P><V><P><N><P><D><Y><E><P><I><R><K><G><Q><R><D><L><Y><S><G><L><N><Q><R><R><I> | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region .<BOP> | P07766 |
Q6NSI3 | FA53A_HUMAN | Dorsal neural-tube nuclear protein | Homo | <M><V><T><L><I><T><E><K><L><Q><S><Q><S><L><D><D><L><T><C><K><A><E><A><G><P><L><Q><Y><S><A><E><T><L><N><K><S><G><R><L><F><P><L><E><L><N><D><Q><S><P><W><K><V><F><S><G><G><P><P><V><R><S><Q><A><A><T><G><P><D><F><S><F><L><P><G><L><S><A><A><A><H><T><M><G><L><Q><W><Q><P><Q><S><P><R><P><G><A><G><L><G><A><A><S><T><V><D><P><S><E><S><T><G><S><S><T><A><P><P><T><K><R><H><C><R><S><L><S><E><P><E><E><L><V><R><C><R><S><P><W><R><P><G><S><S><K><V><W><T><P><V><S><K><R><R><C><D><S><G><G><S><A><T><R><Q><G><S><P><G><A><V><L><P><R><S><A><V><W><S><T><G><P><T><S><P><A><T><P><R><P><S><S><A><S><G><G><F><V><D><S><S><E><G><S><A><G><S><G><P><L><W><C><S><A><E><S><C><L><P><S><T><R><R><R><P><S><L><S><Q><E><R><L><A><G><A><G><T><P><L><P><W><A><S><S><S><P><T><S><T><P><A><L><G><G><R><R><G><L><L><R><C><R><S><Q><P><C><V><L><S><G><K><R><S><R><R><K><R><R><R><E><E><D><A><R><W><T><R><P><S><L><D><F><L><K><M><T><Q><T><L><K><N><S><K><S><L><C><S><L><N><Y><E><D><D><D><E><D><D><T><P><V><K><T><V><L><S><S><P><C><D><S><R><G><L><P><G><I><T><M><P><G><C><S><Q><R><G><L><R><T><S><P><V><H><P><N><L><W><A><S><R><E><S><V><T><S><D><G><S><R><R><S><S><G><D><P><R><D><G><D><S><V><G><E><E><G><V><F><P><R><A><R><W><E><L><D><L><E><Q><I><E><N><N> | May play an important role in neural development; the dorsomedial roof of the third ventricle.<BOP> | Q6NSI3 |
Q96IK1 | BOD1_HUMAN | Protein FAM44B | Homo | <M><A><D><G><G><G><G><G><G><T><G><A><V><G><G><G><G><T><S><Q><A><S><A><G><A><A><T><G><A><T><G><A><S><G><G><G><G><P><I><N><P><A><S><L><P><P><G><D><P><Q><L><I><A><L><I><V><E><Q><L><K><S><R><G><L><F><D><S><F><R><R><D><C><L><A><D><V><D><T><K><P><A><Y><Q><N><L><R><Q><K><V><D><N><F><V><S><T><H><L><D><K><Q><E><W><N><P><T><M><N><K><N><Q><L><R><N><G><L><R><Q><S><V><V><Q><S><G><M><L><E><A><G><V><D><R><I><I><S><Q><V><V><D><P><K><L><N><H><I><F><R><P><Q><I><E><R><A><I><H><E><F><L><A><A><Q><K><K><A><A><V><P><A><P><P><P><E><P><E><G><Q><D><P><P><A><P><S><Q><D><T><S> | Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.<BOP> | Q96IK1 |
P50213 | IDH3A_HUMAN | NAD(+)-specific ICDH subunit alpha | Homo | <M><A><G><P><A><W><I><S><K><V><S><R><L><L><G><A><F><H><N><P><K><Q><V><T><R><G><F><T><G><G><V><Q><T><V><T><L><I><P><G><D><G><I><G><P><E><I><S><A><A><V><M><K><I><F><D><A><A><K><A><P><I><Q><W><E><E><R><N><V><T><A><I><Q><G><P><G><G><K><W><M><I><P><S><E><A><K><E><S><M><D><K><N><K><M><G><L><K><G><P><L><K><T><P><I><A><A><G><H><P><S><M><N><L><L><L><R><K><T><F><D><L><Y><A><N><V><R><P><C><V><S><I><E><G><Y><K><T><P><Y><T><D><V><N><I><V><T><I><R><E><N><T><E><G><E><Y><S><G><I><E><H><V><I><V><D><G><V><V><Q><S><I><K><L><I><T><E><G><A><S><K><R><I><A><E><F><A><F><E><Y><A><R><N><N><H><R><S><N><V><T><A><V><H><K><A><N><I><M><R><M><S><D><G><L><F><L><Q><K><C><R><E><V><A><E><S><C><K><D><I><K><F><N><E><M><Y><L><D><T><V><C><L><N><M><V><Q><D><P><S><Q><F><D><V><L><V><M><P><N><L><Y><G><D><I><L><S><D><L><C><A><G><L><I><G><G><L><G><V><T><P><S><G><N><I><G><A><N><G><V><A><I><F><E><S><V><H><G><T><A><P><D><I><A><G><K><D><M><A><N><P><T><A><L><L><L><S><A><V><M><M><L><R><H><M><G><L><F><D><H><A><A><R><I><E><A><A><C><F><A><T><I><K><D><G><K><S><L><T><K><D><L><G><G><N><A><K><C><S><D><F><T><E><E><I><C><R><R><V><K><D><L><D> | Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.<BOP> | P50213 |
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