accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q13510 | ASAH1_HUMAN | Acid ceramidase subunit beta | Homo | <M><P><G><R><S><C><V><A><L><V><L><L><A><A><A><V><S><C><A><V><A><Q><H><A><P><P><W><T><E><D><C><R><K><S><T><Y><P><P><S><G><P><T><Y><R><G><A><V><P><W><Y><T><I><N><L><D><L><P><P><Y><K><R><W><H><E><L><M><L><D><K><A><P><V><L><K><V><I><V><N><S><L><K><N><M><I><N><T><F><V><P><S><G><K><I><M><Q><V><V><D><E><K><L><P><G><L><L><G><N... | May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity.<BOP> | Q13510 |
Q2QL34 | MP17L_HUMAN | M-LP homolog | Homo | <M><A><G><W><W><P><A><L><S><R><A><A><R><R><H><P><W><P><T><N><V><L><L><Y><G><S><L><V><S><A><G><D><A><L><Q><Q><R><L><Q><G><R><E><A><N><W><R><Q><T><R><R><V><A><T><L><V><V><T><F><H><A><N><F><N><Y><V><W><L><R><L><L><E><R><A><L><P><G><R><A><P><H><A><L><L><A><K><L><L><C><D><Q><V><V><G><A><P><I><A><V><S><A><F><Y><V><G><M><S><I... | Isoform 1 participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.<BOP> | Q2QL34 |
Q9NVR7 | TBCC1_HUMAN | TBCC domain-containing protein 1 | Homo | <M><D><Q><S><R><V><L><L><W><V><K><A><E><P><F><I><V><G><A><L><Q><V><P><P><P><S><K><F><S><L><H><Y><L><R><K><I><S><T><Y><V><Q><I><R><A><T><E><G><A><Y><P><R><L><Y><W><S><T><W><R><H><I><A><C><G><K><L><Q><L><A><K><D><L><A><W><L><Y><F><E><I><F><D><S><L><S><M><K><T><P><E><E><R><L><E><W><S><E><V><L><S><N><C><M><S><E><E><E><V><E... | Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.<BOP> | Q9NVR7 |
Q96HF1 | SFRP2_HUMAN | Secreted apoptosis-related protein 1 | Homo | <M><L><Q><G><P><G><S><L><L><L><L><F><L><A><S><H><C><C><L><G><S><A><R><G><L><F><L><F><G><Q><P><D><F><S><Y><K><R><S><N><C><K><P><I><P><A><N><L><Q><L><C><H><G><I><E><Y><Q><N><M><R><L><P><N><L><L><G><H><E><T><M><K><E><V><L><E><Q><A><G><A><W><I><P><L><V><M><K><Q><C><H><P><D><T><K><K><F><L><C><S><L><F><A><P><V><C><L><D><D><L... | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.<BOP> | Q96HF1 |
Q5U5Q3 | MEX3C_HUMAN | RING-type E3 ubiquitin transferase MEX3C | Homo | <M><P><S><G><S><S><A><A><L><A><L><A><A><A><P><A><P><L><P><Q><P><P><P><P><P><P><P><P><P><P><P><L><P><P><P><S><G><G><P><E><L><E><G><D><G><L><L><L><R><E><R><L><A><A><L><G><L><D><D><P><S><P><A><E><P><G><A><P><A><L><R><A><P><A><A><A><A><Q><G><Q><A><R><R><A><A><E><L><S><P><E><E><R><A><P><P><G><R><P><G><A><P><E><A><A><E><L><E... | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.<BOP> | Q5U5Q3 |
P22532 | SPR2D_HUMAN | Small proline-rich protein II | Homo | <M><S><Y><Q><Q><Q><Q><C><K><Q><P><C><Q><P><P><P><V><C><P><T><P><K><C><P><E><P><C><P><P><P><K><C><P><E><P><C><P><S><P><K><C><P><Q><P><C><P><P><Q><Q><C><Q><Q><K><Y><P><P><V><T><P><S><P><P><C><Q><P><K><C><P><P><K><S><K> | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.<BOP> | P22532 |
O43167 | ZBT24_HUMAN | Zinc finger protein 450 | Homo | <M><A><E><T><S><P><E><P><S><G><Q><L><V><V><H><S><D><A><H><S><D><T><V><L><A><S><F><E><D><Q><R><K><K><G><F><L><C><D><I><T><L><I><V><E><N><V><H><F><R><A><H><K><A><L><L><A><A><S><S><E><Y><F><S><M><M><F><A><E><E><G><E><I><G><Q><S><I><Y><M><L><E><G><M><V><A><D><T><F><G><I><L><L><E><F><I><Y><T><G><Y><L><H><A><S><E><K><S><T><E... | May be involved in BMP2-induced transcription.<BOP> | O43167 |
P24863 | CCNC_HUMAN | SRB11 homolog | Homo | <M><A><G><N><F><W><Q><S><S><H><Y><L><Q><W><I><L><D><K><Q><D><L><L><K><E><R><Q><K><D><L><K><F><L><S><E><E><E><Y><W><K><L><Q><I><F><F><T><N><V><I><Q><A><L><G><E><H><L><K><L><R><Q><Q><V><I><A><T><A><T><V><Y><F><K><R><F><Y><A><R><Y><S><L><K><S><I><D><P><V><L><M><A><P><T><C><V><F><L><A><S><K><V><E><E><F><G><V><V><S><N><T><R... | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoter... | P24863 |
Q8IYP9 | ZDH23_HUMAN | Zinc finger DHHC domain-containing protein 23 | Homo | <M><T><Q><K><G><S><M><K><P><V><K><K><K><K><T><E><E><P><E><L><E><P><L><C><C><C><E><Y><I><D><R><N><G><E><K><N><H><V><A><T><C><L><C><D><C><Q><D><L><D><E><G><C><D><R><W><I><T><C><K><S><L><Q><P><E><T><C><E><R><I><M><D><T><I><S><D><R><L><R><I><P><W><L><R><G><A><K><K><V><N><I><S><I><I><P><P><L><V><L><L><P><V><F><L><H><V><A><S... | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and ... | Q8IYP9 |
P46976 | GLYG_HUMAN | Glycogenin-1 | Homo | <M><T><D><Q><A><F><V><T><L><T><T><N><D><A><Y><A><K><G><A><L><V><L><G><S><S><L><K><Q><H><R><T><T><R><R><L><V><V><L><A><T><P><Q><V><S><D><S><M><R><K><V><L><E><T><V><F><D><E><V><I><M><V><D><V><L><D><S><G><D><S><A><H><L><T><L><M><K><R><P><E><L><G><V><T><L><T><K><L><H><C><W><S><L><T><Q><Y><S><K><C><V><F><M><D><A><D><T><L><V... | Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.<BOP> | P46976 |
Q9HB71 | CYBP_HUMAN | Siah-interacting protein | Homo | <M><A><S><E><E><L><Q><K><D><L><E><E><V><K><V><L><L><E><K><A><T><R><K><R><V><R><D><A><L><T><A><E><K><S><K><I><E><T><E><I><K><N><K><M><Q><Q><K><S><Q><K><K><A><E><L><L><D><N><E><K><P><A><A><V><V><A><P><I><T><T><G><Y><T><V><K><I><S><N><Y><G><W><D><Q><S><D><K><F><V><K><I><Y><I><T><L><T><G><V><H><Q><V><P><T><E><N><V><Q><V><H... | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<BOP> | Q9HB71 |
Q96E14 | RMI2_HUMAN | BLM-associated protein of 18 kDa | Homo | <M><A><A><A><A><D><S><F><S><G><G><P><A><G><V><R><L><P><R><S><P><P><L><K><V><L><A><E><Q><L><R><R><D><A><E><G><G><P><G><A><W><R><L><S><R><A><A><A><G><R><G><P><L><D><L><A><A><V><W><M><Q><G><R><V><V><M><A><D><R><G><E><A><R><L><R><D><P><S><G><D><F><S><V><R><G><L><E><R><V><P><R><G><R><P><C><L><V><P><G><K><Y><V><M><V><M><G><V... | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing ... | Q96E14 |
Q06136 | KDSR_HUMAN | Short chain dehydrogenase/reductase family 35C member 1 | Homo | <M><L><L><L><A><A><A><F><L><V><A><F><V><L><L><L><Y><M><V><S><P><L><I><S><P><K><P><L><A><L><P><G><A><H><V><V><V><T><G><G><S><S><G><I><G><K><C><I><A><I><E><C><Y><K><Q><G><A><F><I><T><L><V><A><R><N><E><D><K><L><L><Q><A><K><K><E><I><E><M><H><S><I><N><D><K><Q><V><V><L><C><I><S><V><D><V><S><Q><D><Y><N><Q><V><E><N><V><I><K><Q... | Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).<BOP> | Q06136 |
P28328 | PEX2_HUMAN | RING finger protein 72 | Homo | <M><A><S><R><K><E><N><A><K><S><A><N><R><V><L><R><I><S><Q><L><D><A><L><E><L><N><K><A><L><E><Q><L><V><W><S><Q><F><T><Q><C><F><H><G><F><K><P><G><L><L><A><R><F><E><P><E><V><K><A><C><L><W><V><F><L><W><R><F><T><I><Y><S><K><N><A><T><V><G><Q><S><V><L><N><I><K><Y><K><N><D><F><S><P><N><L><R><Y><Q><P><P><S><K><N><Q><K><I><W><Y><A... | Somewhat implicated in the biogenesis of peroxisomes.<BOP> | P28328 |
Q9NPJ8 | NXT2_HUMAN | Protein p15-2 | Homo | <M><A><T><S><L><D><F><K><T><Y><V><D><Q><A><C><R><A><A><E><E><F><V><N><I><Y><Y><E><T><M><D><K><R><R><R><A><L><T><R><L><Y><L><D><K><A><T><L><I><W><N><G><N><A><V><S><G><L><D><A><L><N><N><F><F><D><T><L><P><S><S><E><F><Q><V><N><M><L><D><C><Q><P><V><H><E><Q><A><T><Q><S><Q><T><T><V><L><V><V><T><S><G><T><V><K><F><D><G><N><K><Q... | Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.<BOP> | Q9NPJ8 |
Q00LT1 | PRCD_HUMAN | Progressive rod-cone degeneration protein | Homo | <M><C><T><T><L><F><L><L><S><T><L><A><M><L><W><R><R><R><F><A><N><R><V><Q><P><E><P><S><D><V><D><G><A><A><R><G><S><S><L><D><A><D><P><Q><S><S><G><R><E><K><E><P><L><K> | Involved in vision.<BOP> | Q00LT1 |
Q6UX41 | BTNL8_HUMAN | Butyrophilin-like protein 8 | Homo | <M><A><L><M><L><S><L><V><L><S><L><L><K><L><G><S><G><Q><W><Q><V><F><G><P><D><K><P><V><Q><A><L><V><G><E><D><A><A><F><S><C><F><L><S><P><K><T><N><A><E><A><M><E><V><R><F><F><R><G><Q><F><S><S><V><V><H><L><Y><R><D><G><K><D><Q><P><F><M><Q><M><P><Q><Y><Q><G><R><T><K><L><V><K><D><S><I><A><E><G><R><I><S><L><R><L><E><N><I><T><V><L... | May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.<BOP> | Q6UX41 |
P30740 | ILEU_HUMAN | Serpin B1 | Homo | <M><E><Q><L><S><S><A><N><T><R><F><A><L><D><L><F><L><A><L><S><E><N><N><P><A><G><N><I><F><I><S><P><F><S><I><S><S><A><M><A><M><V><F><L><G><T><R><G><N><T><A><A><Q><L><S><K><T><F><H><F><N><T><V><E><E><V><H><S><R><F><Q><S><L><N><A><D><I><N><K><R><G><A><S><Y><I><L><K><L><A><N><R><L><Y><G><E><K><T><Y><N><F><L><P><E><F><L><V><S... | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis . Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when re... | P30740 |
Q8N441 | FGRL1_HUMAN | Fibroblast growth factor receptor 5 | Homo | <M><T><P><S><P><L><L><L><L><L><L><P><P><L><L><L><G><A><F><P><P><A><A><A><A><R><G><P><P><K><M><A><D><K><V><V><P><R><Q><V><A><R><L><G><R><T><V><R><L><Q><C><P><V><E><G><D><P><P><P><L><T><M><W><T><K><D><G><R><T><I><H><S><G><W><S><R><F><R><V><L><P><Q><G><L><K><V><K><Q><V><E><R><E><D><A><G><V><Y><V><C><K><A><T><N><G><F><G><S... | Has a negative effect on cell proliferation.<BOP> | Q8N441 |
Q14943 | KI3S1_HUMAN | Natural killer-associated transcript 10 | Homo | <M><L><L><M><V><V><S><M><A><C><V><G><L><F><L><V><Q><R><A><G><P><H><M><G><G><Q><D><K><P><F><L><S><A><W><P><S><A><V><V><P><R><G><G><H><V><T><L><R><C><H><Y><R><H><R><F><N><N><F><M><L><Y><K><E><D><R><I><H><V><P><I><F><H><G><R><I><F><Q><E><G><F><N><M><S><P><V><T><T><A><H><A><G><N><Y><T><C><R><G><S><H><P><H><S><P><T><G><W><S... | Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.<BOP> | Q14943 |
Q8NGE5 | O10A7_HUMAN | Olfactory receptor OR12-6 | Homo | <M><I><C><E><N><H><T><R><V><T><E><F><I><L><L><G><F><T><N><N><P><E><M><Q><V><S><L><F><I><F><F><L><A><I><Y><T><V><T><L><L><G><N><F><L><I><V><T><V><T><S><V><D><L><A><L><Q><T><P><M><Y><F><F><L><Q><N><L><S><L><L><E><V><C><F><T><L><V><M><V><P><K><M><L><V><D><L><V><S><P><R><K><I><I><S><F><V><G><C><G><T><Q><M><Y><F><F><F><F><F... | Odorant receptor.<BOP> | Q8NGE5 |
Q9HC44 | GPBL1_HUMAN | GC-rich promoter-binding protein 1-like 1 | Homo | <M><A><Q><H><D><F><V><P><A><W><L><N><F><S><T><P><Q><S><A><K><S><P><T><A><T><F><E><K><H><G><E><H><L><P><R><G><E><G><R><F><G><V><S><R><R><R><H><N><S><S><D><G><F><F><N><N><G><P><L><R><T><A><G><D><S><W><H><Q><P><S><L><F><R><H><D><S><V><D><S><G><V><S><K><G><A><Y><A><G><I><T><G><N><P><S><G><W><H><S><S><S><R><G><H><D><G><M><S... | Possible transcription factor.<BOP> | Q9HC44 |
P06028 | GLPB_HUMAN | Sialoglycoprotein delta | Homo | <M><Y><G><K><I><I><F><V><L><L><L><S><E><I><V><S><I><S><A><L><S><T><T><E><V><A><M><H><T><S><T><S><S><S><V><T><K><S><Y><I><S><S><Q><T><N><G><E><T><G><Q><L><V><H><R><F><T><V><P><A><P><V><V><I><I><L><I><I><L><C><V><M><A><G><I><I><G><T><I><L><L><I><S><Y><S><I><R><R><L><I><K><A> | This protein is a minor sialoglycoprotein in erythrocyte membranes.<BOP> | P06028 |
Q96LB2 | MRGX1_HUMAN | Sensory neuron-specific G-protein coupled receptor 3/4 | Homo | <M><D><P><T><I><S><T><L><D><T><E><L><T><P><I><N><G><T><E><E><T><L><C><Y><K><Q><T><L><S><L><T><V><L><T><C><I><V><S><L><V><G><L><T><G><N><A><V><V><L><W><L><L><G><C><R><M><R><R><N><A><F><S><I><Y><I><L><N><L><A><A><A><D><F><L><F><L><S><G><R><L><I><Y><S><L><L><S><F><I><S><I><P><H><T><I><S><K><I><L><Y><P><V><M><M><F><S><Y><F... | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoke... | Q96LB2 |
Q15653 | IKBB_HUMAN | Thyroid receptor-interacting protein 9 | Homo | <M><A><G><V><A><C><L><G><K><A><A><D><A><D><E><W><C><D><S><G><L><G><S><L><G><P><D><A><A><A><P><G><G><P><G><L><G><A><E><L><G><P><G><L><S><W><A><P><L><V><F><G><Y><V><T><E><D><G><D><T><A><L><H><L><A><V><I><H><Q><H><E><P><F><L><D><F><L><L><G><F><S><A><G><T><E><Y><M><D><L><Q><N><D><L><G><Q><T><A><L><H><L><A><A><I><L><G><E><T... | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKI... | Q15653 |
Q9NPA1 | KCMB3_HUMAN | Slo-beta-3 | Homo | <M><D><F><S><P><S><S><E><L><G><F><H><F><V><A><F><I><L><L><T><R><H><R><T><A><F><P><A><S><G><K><K><R><E><T><D><Y><S><D><G><D><P><L><D><V><H><K><R><L><P><S><S><A><G><E><D><R><A><V><M><L><G><F><A><M><M><G><F><S><V><L><M><F><F><L><L><G><T><T><I><L><K><P><F><M><L><S><I><Q><R><E><E><S><T><C><T><A><I><H><T><D><I><M><D><D><W><L... | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially i... | Q9NPA1 |
A6NEC2 | PSAL_HUMAN | Puromycin-sensitive aminopeptidase-like protein | Homo | <M><W><L><A><A><A><A><P><S><L><A><R><R><L><L><F><L><G><P><P><P><P><P><L><L><L><L><V><F><S><R><S><S><R><R><R><L><H><S><L><G><L><A><A><M><P><E><K><R><P><F><E><R><L><P><A><D><V><S><P><I><N><C><S><L><C><L><K><P><D><L><L><D><F><T><F><E><G><K><L><E><A><A><A><Q><V><R><Q><A><T><N><Q><I><V><M><N><C><A><D><I><D><I><I><T><A><S><Y... | Aminopeptidase with broad substrate specificity to several peptides.<BOP> | A6NEC2 |
P52951 | GBX2_HUMAN | Gastrulation and brain-specific homeobox protein 2 | Homo | <M><S><A><A><F><P><P><S><L><M><M><M><Q><R><P><L><G><S><S><T><A><F><S><I><D><S><L><I><G><S><P><P><Q><P><S><P><G><H><F><V><Y><T><G><Y><P><M><F><M><P><Y><R><P><V><V><L><P><P><P><P><P><P><P><P><A><L><P><Q><A><A><L><Q><P><A><L><P><P><A><H><P><H><H><Q><I><P><S><L><P><T><G><F><C><S><S><L><A><Q><G><M><A><L><T><S><T><L><M><A><T... | May act as a transcription factor for cell pluripotency and differentiation in the embryo.<BOP> | P52951 |
Q9BYJ4 | TRI34_HUMAN | RING finger protein 21 | Homo | <M><A><S><K><I><L><L><N><V><Q><E><E><V><T><C><P><I><C><L><E><L><L><T><E><P><L><S><L><D><C><G><H><S><L><C><R><A><C><I><T><V><S><N><K><E><A><V><T><S><M><G><G><K><S><S><C><P><V><C><G><I><S><Y><S><F><E><H><L><Q><A><N><Q><H><L><A><N><I><V><E><R><L><K><E><V><K><L><S><P><D><N><G><K><K><R><D><L><C><D><H><H><G><E><K><L><L><L><F... | May function as antiviral protein and may contribute to the defense against retroviral infections.<BOP> | Q9BYJ4 |
P62888 | RL30_HUMAN | Large ribosomal subunit protein eL30 | Homo | <M><V><A><A><K><K><T><K><K><S><L><E><S><I><N><S><R><L><Q><L><V><M><K><S><G><K><Y><V><L><G><Y><K><Q><T><L><K><M><I><R><Q><G><K><A><K><L><V><I><L><A><N><N><C><P><A><L><R><K><S><E><I><E><Y><Y><A><M><L><A><K><T><G><V><H><H><Y><S><G><N><N><I><E><L><G><T><A><C><G><K><Y><Y><R><V><C><T><L><A><I><I><D><P><G><D><S><D><I><I><R><S... | Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP> | P62888 |
O00478 | BT3A3_HUMAN | Butyrophilin subfamily 3 member A3 | Homo | <M><K><M><A><S><S><L><A><F><L><L><L><N><F><H><V><S><L><F><L><V><Q><L><L><T><P><C><S><A><Q><F><S><V><L><G><P><S><G><P><I><L><A><M><V><G><E><D><A><D><L><P><C><H><L><F><P><T><M><S><A><E><T><M><E><L><R><W><V><S><S><S><L><R><Q><V><V><N><V><Y><A><D><G><K><E><V><E><D><R><Q><S><A><P><Y><R><G><R><T><S><I><L><R><D><G><I><T><A><G... | Plays a role in T-cell responses in the adaptive immune response.<BOP> | O00478 |
Q6VVB1 | NHLC1_HUMAN | RING-type E3 ubiquitin transferase NHLRC1 | Homo | <M><A><A><E><A><S><E><S><G><P><A><L><H><E><L><M><R><E><A><E><I><S><L><L><E><C><K><V><C><F><E><K><F><G><H><R><Q><Q><R><R><P><R><N><L><S><C><G><H><V><V><C><L><A><C><V><A><A><L><A><H><P><R><T><L><A><L><E><C><P><F><C><R><R><A><C><R><G><C><D><T><S><D><C><L><P><V><L><H><L><I><E><L><L><G><S><A><L><R><Q><S><P><A><A><H><R><A><A... | E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the... | Q6VVB1 |
Q8TAX7 | MUC7_HUMAN | Salivary mucin-7 | Homo | <M><K><T><L><P><L><F><V><C><I><C><A><L><S><A><C><F><S><F><S><E><G><R><E><R><D><H><E><L><R><H><R><R><H><H><H><Q><S><P><K><S><H><F><E><L><P><H><Y><P><G><L><L><A><H><Q><K><P><F><I><R><K><S><Y><K><C><L><H><K><R><C><R><P><K><L><P><P><S><P><N><N><P><P><K><F><P><N><P><H><Q><P><P><K><H><P><D><K><N><S><S><V><V><N><P><T><L><V><A... | May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.<BOP> | Q8TAX7 |
Q96DR8 | MUCL1_HUMAN | Small breast epithelial mucin | Homo | <M><K><F><L><A><V><L><V><L><L><G><V><S><I><F><L><V><S><A><Q><N><P><T><T><A><A><P><A><D><T><Y><P><A><T><G><P><A><D><D><E><A><P><D><A><E><T><T><A><A><A><T><T><A><T><T><A><A><P><T><T><A><T><T><A><A><S><T><T><A><R><K><D><I><P><V><L><P><K><W><V><G><D><L><P><N><G><R><V><C><P> | May play a role as marker for the diagnosis of metastatic breast cancer.<BOP> | Q96DR8 |
Q495W5 | FUT11_HUMAN | Galactoside 3-L-fucosyltransferase 11 | Homo | <M><A><A><G><P><I><R><V><V><L><V><L><L><G><V><L><S><V><C><A><A><S><G><H><G><S><V><A><E><R><E><A><G><G><E><A><E><W><A><E><P><W><D><G><A><V><F><R><P><P><S><A><L><G><A><V><G><V><T><R><S><S><G><T><P><R><P><G><R><E><E><A><G><D><L><P><V><L><L><W><W><S><P><G><L><F><P><H><F><P><G><D><S><E><R><I><E><C><A><R><G><A><C><V><A><S><R... | Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit.<BOP> | Q495W5 |
Q96RQ3 | MCCA_HUMAN | 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha | Homo | <M><A><A><A><S><A><V><S><V><L><L><V><A><A><E><R><N><R><W><H><R><L><P><S><L><L><L><P><P><R><T><W><V><W><R><Q><R><T><M><K><Y><T><T><A><T><G><R><N><I><T><K><V><L><I><A><N><R><G><E><I><A><C><R><V><M><R><T><A><K><K><L><G><V><Q><T><V><A><V><Y><S><E><A><D><R><N><S><M><H><V><D><M><A><D><E><A><Y><S><I><G><P><A><P><S><Q><Q><S><Y... | Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.<BOP> | Q96RQ3 |
Q96BD5 | PF21A_HUMAN | BRAF35-HDAC complex protein BHC80 | Homo | <M><E><L><Q><T><L><Q><E><A><L><K><V><E><I><Q><V><H><Q><K><L><V><A><Q><M><K><Q><D><P><Q><N><A><D><L><K><K><Q><L><H><E><L><Q><A><K><I><T><A><L><S><E><K><Q><K><R><V><V><E><Q><L><R><K><N><L><I><V><K><Q><E><Q><P><D><K><F><Q><I><Q><P><L><P><Q><S><E><N><K><L><Q><T><A><Q><Q><Q><P><L><Q><Q><L><Q><Q><Q><Q><Q><Y><H><H><H><H><A><Q... | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it m... | Q96BD5 |
P06312 | KV401_HUMAN | Ig kappa chain V-IV region STH | Homo | <M><V><L><Q><T><Q><V><F><I><S><L><L><L><W><I><S><G><A><Y><G><D><I><V><M><T><Q><S><P><D><S><L><A><V><S><L><G><E><R><A><T><I><N><C><K><S><S><Q><S><V><L><Y><S><S><N><N><K><N><Y><L><A><W><Y><Q><Q><K><P><G><Q><P><P><K><L><L><I><Y><W><A><S><T><R><E><S><G><V><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><A><E... | V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as rece... | P06312 |
P26641 | EF1G_HUMAN | eEF-1B gamma | Homo | <M><A><A><G><T><L><Y><T><Y><P><E><N><W><R><A><F><K><A><L><I><A><A><Q><Y><S><G><A><Q><V><R><V><L><S><A><P><P><H><F><H><F><G><Q><T><N><R><T><P><E><F><L><R><K><F><P><A><G><K><V><P><A><F><E><G><D><D><G><F><C><V><F><E><S><N><A><I><A><Y><Y><V><S><N><E><E><L><R><G><S><T><P><E><A><A><A><Q><V><V><Q><W><V><S><F><A><D><S><D><I><V... | Probably plays a role in anchoring the complex to other cellular components.<BOP> | P26641 |
Q96R27 | OR2M4_HUMAN | Olfactory receptor TPCR100 | Homo | <M><V><W><E><N><Q><T><F><N><S><I><F><I><L><L><G><I><F><N><H><S><P><T><H><T><F><L><F><S><L><V><L><G><I><F><S><L><A><L><M><E><N><I><S><M><V><L><L><I><Y><I><E><K><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><L><M><L><I><C><T><T><L><P><K><M><I><F><S><Y><L><S><G><K><K><S><I><S><L><A><G><C><G><T><Q><I><F><F><Y><V><S><L... | Odorant receptor.<BOP> | Q96R27 |
P55735 | SEC13_HUMAN | SEC13-related protein | Homo | <M><V><S><V><I><N><T><V><D><T><S><H><E><D><M><I><H><D><A><Q><M><D><Y><Y><G><T><R><L><A><T><C><S><S><D><R><S><V><K><I><F><D><V><R><N><G><G><Q><I><L><I><A><D><L><R><G><H><E><G><P><V><W><Q><V><A><W><A><H><P><M><Y><G><N><I><L><A><S><C><S><Y><D><R><K><V><I><I><W><R><E><E><N><G><T><W><E><K><S><H><E><H><A><G><H><D><S><S><V><N... | As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 .<BO... | P55735 |
Q9NZ01 | TECR_HUMAN | Trans-2,3-enoyl-CoA reductase | Homo | <M><K><H><Y><E><V><E><I><L><D><A><K><T><R><E><K><L><C><F><L><D><K><V><E><P><H><A><T><I><A><E><I><K><N><L><F><T><K><T><H><P><Q><W><Y><P><A><R><Q><S><L><R><L><D><P><K><G><K><S><L><K><D><E><D><V><L><Q><K><L><P><V><G><T><T><A><T><L><Y><F><R><D><L><G><A><Q><I><S><W><V><T><V><F><L><T><E><Y><A><G><P><L><F><I><Y><L><L><F><Y><F... | Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway . Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle . This endoplasmic reti... | Q9NZ01 |
Q8WWC4 | MAIP1_HUMAN | Matrix AAA peptidase-interacting protein 1 | Homo | <M><A><L><A><A><R><L><L><P><Q><F><L><H><S><R><S><L><P><C><G><A><V><R><L><R><T><P><A><V><A><E><V><R><L><P><S><A><T><L><C><Y><F><C><R><C><R><L><G><L><G><A><A><L><F><P><R><S><A><R><A><L><A><A><S><A><L><P><A><Q><G><S><R><W><P><V><L><S><S><P><G><L><P><A><A><F><A><S><F><P><A><C><P><Q><R><S><Y><S><T><E><E><K><P><Q><Q><H><Q><K... | Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation . Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase... | Q8WWC4 |
A0A0B4J264 | TV381_HUMAN | T cell receptor alpha variable 38-1 | Homo | <M><T><R><V><S><L><L><W><A><V><V><V><S><T><C><L><E><S><G><M><A><Q><T><V><T><Q><S><Q><P><E><M><S><V><Q><E><A><E><T><V><T><L><S><C><T><Y><D><T><S><E><N><N><Y><Y><L><F><W><Y><K><Q><P><P><S><R><Q><M><I><L><V><I><R><Q><E><A><Y><K><Q><Q><N><A><T><E><N><R><F><S><V><N><F><Q><K><A><A><K><S><F><S><L><K><I><S><D><S><Q><L><G><D><T... | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (... | A0A0B4J264 |
Q9BUN8 | DERL1_HUMAN | Der1-like protein 1 | Homo | <M><S><D><I><G><D><W><F><R><S><I><P><A><I><T><R><Y><W><F><A><A><T><V><A><V><P><L><V><G><K><L><G><L><I><S><P><A><Y><L><F><L><W><P><E><A><F><L><Y><R><F><Q><I><W><R><P><I><T><A><T><F><Y><F><P><V><G><P><G><T><G><F><L><Y><L><V><N><L><Y><F><L><Y><Q><Y><S><T><R><L><E><T><G><A><F><D><G><R><P><A><D><Y><L><F><M><L><L><F><N><W><I... | (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation proce... | Q9BUN8 |
Q9NX36 | DJC28_HUMAN | DnaJ homolog subfamily C member 28 | Homo | <M><N><T><M><Y><V><M><M><A><Q><I><L><R><S><H><L><I><K><A><T><V><I><P><N><R><V><K><M><L><P><Y><F><G><I><I><R><N><R><M><M><S><T><H><K><S><K><K><K><I><R><E><Y><Y><R><L><L><N><V><E><E><G><C><S><A><D><E><V><R><E><S><F><H><K><L><A><K><Q><Y><H><P><D><S><G><S><N><T><A><D><S><A><T><F><I><R><I><E><K><A><Y><R><K><V><L><S><H><V><I... | May have a role in protein folding or as a chaperone.<BOP> | Q9NX36 |
Q5NDL2 | EOGT_HUMAN | Extracellular O-linked N-acetylglucosamine transferase | Homo | <M><L><M><L><F><V><F><G><V><L><L><H><E><V><S><L><S><G><Q><N><E><A><P><P><N><T><H><S><I><P><G><E><P><L><Y><N><Y><A><S><I><R><L><P><E><E><H><I><P><F><F><L><H><N><N><R><H><I><A><T><V><C><R><K><D><S><L><C><P><Y><K><K><H><L><E><K><L><K><Y><C><W><G><Y><E><K><S><C><K><P><E><F><R><F><G><Y><P><V><C><S><Y><V><D><M><G><W><T><D><T... | Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded... | Q5NDL2 |
Q9P0V8 | SLAF8_HUMAN | BCM-like membrane protein | Homo | <M><V><M><R><P><L><W><S><L><L><L><W><E><A><L><L><P><I><T><V><T><G><A><Q><V><L><S><K><V><G><G><S><V><L><L><V><A><A><R><P><P><G><F><Q><V><R><E><A><I><W><R><S><L><W><P><S><E><E><L><L><A><T><F><F><R><G><S><L><E><T><L><Y><H><S><R><F><L><G><R><A><Q><L><H><S><N><L><S><L><E><L><G><P><L><E><S><G><D><S><G><N><F><S><V><L><M><V><D... | May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.<BOP> | Q9P0V8 |
P0DMP2 | SRG2B_HUMAN | SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2 | Homo | <M><T><S><P><A><K><F><K><K><D><K><E><I><I><A><E><Y><D><T><Q><V><K><E><I><R><A><Q><L><T><E><Q><M><K><C><L><D><Q><Q><C><E><L><R><V><Q><L><L><Q><D><L><Q><D><F><F><R><K><K><A><E><I><E><M><D><Y><S><R><N><L><E><K><L><A><E><R><F><L><A><K><T><C><S><T><K><D><Q><Q><F><K><K><D><Q><N><V><L><S><P><V><N><C><W><N><L><L><L><N><Q><V><K... | May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 . In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood .<BOP> | P0DMP2 |
Q6NS38 | ALKB2_HUMAN | Oxy DC1 | Homo | <M><D><R><F><L><V><K><G><A><Q><G><G><L><L><R><K><Q><E><E><Q><E><P><T><G><E><E><P><A><V><L><G><G><D><K><E><S><T><R><K><R><P><R><R><E><A><P><G><N><G><G><H><S><A><G><P><S><W><R><H><I><R><A><E><G><L><D><C><S><Y><T><V><L><F><G><K><A><E><A><D><E><I><F><Q><E><L><E><K><E><V><E><Y><F><T><G><A><L><A><R><V><Q><V><F><G><K><W><H><S... | Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA . Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequent... | Q6NS38 |
Q7RTS7 | K2C74_HUMAN | Type-II keratin Kb37 | Homo | <M><S><R><Q><L><N><I><K><S><S><G><D><K><G><N><F><S><V><H><S><A><V><V><P><R><K><A><V><G><S><L><A><S><Y><C><A><A><G><R><G><A><G><A><G><F><G><S><R><S><L><Y><S><L><G><G><N><R><R><I><S><F><N><V><A><G><G><G><V><R><A><G><G><Y><G><F><R><P><G><S><G><Y><G><G><G><R><A><S><G><F><A><G><S><M><F><G><S><V><A><L><G><P><A><C><L><S><V><C... | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).<BOP> | Q7RTS7 |
Q8IU81 | I2BP1_HUMAN | Probable RING-type E3 ubiquitin transferase IRF2BP1 | Homo | <M><A><S><V><Q><A><S><R><R><Q><W><C><Y><L><C><D><L><P><K><M><P><W><A><M><V><W><D><F><S><E><A><V><C><R><G><C><V><N><F><E><G><A><D><R><I><E><L><L><I><D><A><A><R><Q><L><K><R><S><H><V><L><P><E><G><R><S><P><G><P><P><A><L><K><H><P><A><T><K><D><L><A><A><A><A><A><Q><G><P><Q><L><P><P><P><Q><A><Q><P><Q><P><S><G><T><G><G><G><V><S... | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.<BOP> | Q8IU81 |
P40925 | MDHC_HUMAN | Cytosolic malate dehydrogenase | Homo | <M><S><E><P><I><R><V><L><V><T><G><A><A><G><Q><I><A><Y><S><L><L><Y><S><I><G><N><G><S><V><F><G><K><D><Q><P><I><I><L><V><L><L><D><I><T><P><M><M><G><V><L><D><G><V><L><M><E><L><Q><D><C><A><L><P><L><L><K><D><V><I><A><T><D><K><E><D><V><A><F><K><D><L><D><V><A><I><L><V><G><S><M><P><R><R><E><G><M><E><R><K><D><L><L><K><A><N><V><K... | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH . Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation .<BOP> | P40925 |
A0A0A6YYK7 | TVA19_HUMAN | T-cell receptor alpha chain V region HPB-MLT | Homo | <M><L><T><A><S><L><L><R><A><V><I><A><S><I><C><V><V><S><S><M><A><Q><K><V><T><Q><A><Q><T><E><I><S><V><V><E><K><E><D><V><T><L><D><C><V><Y><E><T><R><D><T><T><Y><Y><L><F><W><Y><K><Q><P><P><S><G><E><L><V><F><L><I><R><R><N><S><F><D><E><Q><N><E><I><S><G><R><Y><S><W><N><F><Q><K><S><T><S><S><F><N><F><T><I><T><A><S><Q><V><V><D><S... | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (... | A0A0A6YYK7 |
Q9H963 | ZN702_HUMAN | Putative zinc finger protein 702 | Homo | <M><R><E><K><S><F><Q><C><N><E><S><G><K><A><F><N><C><S><S><L><L><K><K><C><Q><I><I><H><L><G><E><K><K><Y><K><C><D><I><C><G><K><V><F><N><Q><K><R><Y><L><A><Y><H><H><R><C><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><T><F><S><Y><K><S><S><L><V><I><H><K><A><I><H><T><G><E><K><P><H><K><C><N><E><C><G><K><V><F><N><Q><K><A><Y><L><A><S... | May be involved in transcriptional regulation.<BOP> | Q9H963 |
P43356 | MAGA2_HUMAN | MAGE-2 antigen | Homo | <M><P><L><E><Q><R><S><Q><H><C><K><P><E><E><G><L><E><A><R><G><E><A><L><G><L><V><G><A><Q><A><P><A><T><E><E><Q><Q><T><A><S><S><S><S><T><L><V><E><V><T><L><G><E><V><P><A><A><D><S><P><S><P><P><H><S><P><Q><G><A><S><S><F><S><T><T><I><N><Y><T><L><W><R><Q><S><D><E><G><S><S><N><Q><E><E><E><G><P><R><M><F><P><D><L><E><S><E><F><Q><A... | Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p... | P43356 |
Q9Y6I9 | TX264_HUMAN | Putative secreted protein Zsig11 | Homo | <M><S><D><L><L><L><L><G><L><I><G><G><L><T><L><L><L><L><L><T><L><L><A><F><A><G><Y><S><G><L><L><A><G><V><E><V><S><A><G><S><P><P><I><R><N><V><T><V><A><Y><K><F><H><M><G><L><Y><G><E><T><G><R><L><F><T><E><S><C><S><I><S><P><K><L><R><S><I><A><V><Y><Y><D><N><P><H><M><V><P><P><D><K><C><R><C><A><V><G><S><I><L><S><E><G><E><E><S><P... | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . The ATG8-containing isolation membrane (... | Q9Y6I9 |
Q13685 | AAMP_HUMAN | Angio-associated migratory cell protein | Homo | <M><E><S><E><S><E><S><G><A><A><A><D><T><P><P><L><E><T><L><S><F><H><G><D><E><E><I><I><E><V><V><E><L><D><P><G><P><P><D><P><D><D><L><A><Q><E><M><E><D><V><D><F><E><E><E><E><E><E><E><G><N><E><E><G><W><V><L><E><P><Q><E><G><V><V><G><S><M><E><G><P><D><D><S><E><V><T><F><A><L><H><S><A><S><V><F><C><V><S><L><D><P><K><T><N><T><L><A... | Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.<BOP> | Q13685 |
Q6P656 | CF161_HUMAN | Cilia- and flagella-associated protein 161 | Homo | <M><A><Q><N><V><Y><G><P><G><V><R><I><G><N><W><N><E><D><V><Y><L><E><E><E><L><M><K><D><F><L><E><K><R><D><K><G><K><L><L><I><Q><R><S><R><R><L><K><Q><N><L><L><R><P><M><Q><L><S><V><T><E><D><G><Y><I><H><Y><G><D><K><V><M><L><V><N><P><D><D><P><D><T><E><A><D><V><F><L><R><G><D><L><S><L><C><M><T><P><D><E><I><Q><S><H><L><K><D><E><L... | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP> | Q6P656 |
Q8N5W9 | RFLB_HUMAN | Regulator of filamin protein B | Homo | <M><V><G><R><L><S><L><Q><D><V><P><E><L><V><D><A><K><K><K><G><D><G><V><L><D><S><P><D><S><G><L><P><P><S><P><S><P><S><H><W><G><L><A><A><G><G><G><G><G><E><R><A><A><A><P><G><T><L><E><P><D><A><A><A><A><T><P><A><A><P><S><P><A><S><L><P><L><A><P><G><C><A><L><R><L><C><P><L><S><F><G><E><G><V><E><F><D><P><L><P><P><K><E><V><R><Y><T... | Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.<BOP> | Q8N5W9 |
Q4G163 | FBX43_HUMAN | Endogenous meiotic inhibitor 2 | Homo | <M><S><F><K><D><K><D><E><R><I><S><C><L><E><A><Y><V><T><L><T><S><K><S><S><R><F><T><D><E><T><E><I><L><K><M><S><Q><R><H><S><G><Q><A><G><T><E><A><G><N><G><A><D><S><P><P><I><V><N><S><K><Y><S><T><F><R><D><F><C><S><T><S><S><F><Q><D><S><G><Y><N><E><L><K><S><C><S><F><D><N><I><D><K><E><Y><L><G><K><K><E><K><G><P><T><L><L><Y><E><H... | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation . Plays a vi... | Q4G163 |
Q8N335 | GPD1L_HUMAN | Glycerol-3-phosphate dehydrogenase 1-like protein | Homo | <M><A><A><A><P><L><K><V><C><I><V><G><S><G><N><W><G><S><A><V><A><K><I><I><G><N><N><V><K><K><L><Q><K><F><A><S><T><V><K><M><W><V><F><E><E><T><V><N><G><R><K><L><T><D><I><I><N><N><D><H><E><N><V><K><Y><L><P><G><H><K><L><P><E><N><V><V><A><M><S><N><L><S><E><A><V><Q><D><A><D><L><L><V><F><V><I><P><H><Q><F><I><H><R><I><C><D><E><I... | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) b... | Q8N335 |
Q96SC8 | DMTA2_HUMAN | Doublesex- and mab-3-related transcription factor 5 | Homo | <M><E><L><R><S><E><L><P><S><V><P><G><A><A><T><A><A><A><A><T><A><T><G><P><P><V><A><S><V><A><S><V><A><A><A><A><A><A><A><A><S><L><P><V><S><V><A><G><G><L><L><R><G><P><P><L><L><L><R><A><A><E><K><Y><P><R><T><P><K><C><A><R><C><R><N><H><G><V><V><S><A><L><K><G><H><K><R><Y><C><R><W><K><D><C><L><C><A><K><C><T><L><I><A><E><R><Q><R... | May be involved in sexual development.<BOP> | Q96SC8 |
Q9UKL6 | PPCT_HUMAN | StAR-related lipid transfer protein 2 | Homo | <M><E><L><A><A><G><S><F><S><E><E><Q><F><W><E><A><C><A><E><L><Q><Q><P><A><L><A><G><A><D><W><Q><L><L><V><E><T><S><G><I><S><I><Y><R><L><L><D><K><K><T><G><L><Y><E><Y><K><V><F><G><V><L><E><D><C><S><P><T><L><L><A><D><I><Y><M><D><S><D><Y><R><K><Q><W><D><Q><Y><V><K><E><L><Y><E><Q><E><C><N><G><E><T><V><V><Y><W><E><V><K><Y><P><F... | Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.<BOP> | Q9UKL6 |
Q9Y3I1 | FBX7_HUMAN | F-box only protein 7 | Homo | <M><R><L><R><V><R><L><L><K><R><T><W><P><L><E><V><P><E><T><E><P><T><L><G><H><L><R><S><H><L><R><Q><S><L><L><C><T><W><G><Y><S><S><N><T><R><F><T><I><T><L><N><Y><K><D><P><L><T><G><D><E><E><T><L><A><S><Y><G><I><V><S><G><D><L><I><C><L><I><L><Q><D><D><I><P><A><P><N><I><P><S><S><T><D><S><E><H><S><S><L><Q><N><N><E><Q><P><S><L><A... | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autopha... | Q9Y3I1 |
Q15404 | RSU1_HUMAN | Ras suppressor protein 1 | Homo | <M><S><K><S><L><K><K><L><V><E><E><S><R><E><K><N><Q><P><E><V><D><M><S><D><R><G><I><S><N><M><L><D><V><N><G><L><F><T><L><S><H><I><T><Q><L><V><L><S><H><N><K><L><T><M><V><P><P><N><I><A><E><L><K><N><L><E><V><L><N><F><F><N><N><Q><I><E><E><L><P><T><Q><I><S><S><L><Q><K><L><K><H><L><N><L><G><M><N><R><L><N><T><L><P><R><G><F><G><S... | Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.<BOP> | Q15404 |
Q96GK7 | FAH2A_HUMAN | Fumarylacetoacetate hydrolase domain-containing protein 2A | Homo | <M><L><V><S><G><R><R><R><L><L><T><V><L><L><Q><A><Q><K><W><P><F><Q><P><S><R><D><M><R><L><V><Q><F><R><A><P><H><L><V><G><P><H><L><G><L><E><T><G><N><G><G><G><V><I><N><L><N><A><F><D><P><T><L><P><K><T><M><T><Q><F><L><E><Q><G><E><A><T><L><S><V><A><R><R><A><L><A><A><Q><L><P><V><L><P><R><S><E><V><T><F><L><A><P><V><T><R><P><D><K... | May have hydrolase activity.<BOP> | Q96GK7 |
Q9ULA0 | DNPEP_HUMAN | Aspartyl aminopeptidase | Homo | <M><S><G><H><S><P><T><R><G><A><M><Q><V><A><M><N><G><K><A><R><K><E><A><V><Q><T><A><A><K><E><L><L><K><F><V><N><R><S><P><S><P><F><H><A><V><A><E><C><R><N><R><L><L><Q><A><G><F><S><E><L><K><E><T><E><K><W><N><I><K><P><E><S><K><Y><F><M><T><R><N><S><S><T><I><I><A><F><A><V><G><G><Q><Y><V><P><G><N><G><F><S><L><I><G><A><H><T><D><S... | Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.<BOP> | Q9ULA0 |
P51003 | PAPOA_HUMAN | Polynucleotide adenylyltransferase alpha | Homo | <M><P><F><P><V><T><T><Q><G><S><Q><Q><T><Q><P><P><Q><K><H><Y><G><I><T><S><P><I><S><L><A><A><P><K><E><T><D><C><V><L><T><Q><K><L><I><E><T><L><K><P><F><G><V><F><E><E><E><E><E><L><Q><R><R><I><L><I><L><G><K><L><N><N><L><V><K><E><W><I><R><E><I><S><E><S><K><N><L><P><Q><S><V><I><E><N><V><G><G><K><I><F><T><F><G><S><Y><R><L><G><V... | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.<BOP> | P51003 |
P0DJD4 | RBY1C_HUMAN | RNA-binding motif protein, Y chromosome, family 1 member C | Homo | <M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><Q><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G... | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<BOP> | P0DJD4 |
Q15573 | TAF1A_HUMAN | Transcription initiation factor SL1/TIF-IB subunit A | Homo | <M><S><D><F><S><E><E><L><K><G><P><V><T><D><D><E><E><V><E><T><S><V><L><S><G><A><G><M><H><F><P><W><L><Q><T><Y><V><E><T><V><A><I><G><G><K><R><R><K><D><F><A><Q><T><T><S><A><C><L><S><F><I><Q><E><A><L><L><K><H><Q><W><Q><Q><A><A><E><Y><M><Y><S><Y><F><Q><T><L><E><D><S><D><S><Y><K><R><Q><A><A><P><E><I><I><W><K><L><G><S><E><I><L... | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involv... | Q15573 |
P0DN81 | O13C7_HUMAN | Olfactory receptor 13C7 | Homo | <M><V><S><A><N><Q><T><A><S><V><T><E><F><I><L><L><G><L><S><A><H><P><K><L><E><K><T><F><F><V><L><I><L><L><M><Y><L><V><I><L><L><G><N><G><V><L><I><L><M><T><V><S><N><S><H><L><H><M><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><T><S><S><V><P><L><I><L><D><S><F><L><T><P><R><K><T><I><S><F><S><A><C><A><V><Q><M><F><L><S><F><A... | Odorant receptor.<BOP> | P0DN81 |
P08729 | K2C7_HUMAN | Type-II keratin Kb7 | Homo | <M><S><I><H><F><S><S><P><V><F><T><S><R><S><A><A><F><S><G><R><G><A><Q><V><R><L><S><S><A><R><P><G><G><L><G><S><S><S><L><Y><G><L><G><A><S><R><P><R><V><A><V><R><S><A><Y><G><G><P><V><G><A><G><I><R><E><V><T><I><N><Q><S><L><L><A><P><L><R><L><D><A><D><P><S><L><Q><R><V><R><Q><E><E><S><E><Q><I><K><T><L><N><N><K><F><A><S><F><I><D... | Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).<BOP> | P08729 |
Q6ZWL3 | CP4V2_HUMAN | Long-chain fatty acid omega-monooxygenase | Homo | <M><A><G><L><W><L><G><L><V><W><Q><K><L><L><L><W><G><A><A><S><A><L><S><L><A><G><A><S><L><V><L><S><L><L><Q><R><V><A><S><Y><A><R><K><W><Q><Q><M><R><P><I><P><T><V><A><R><A><Y><P><L><V><G><H><A><L><L><M><K><P><D><G><R><E><F><F><Q><Q><I><I><E><Y><T><E><E><Y><R><H><M><P><L><L><K><L><W><V><G><P><V><P><M><V><A><L><Y><N><A><E><N... | A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs . Omega hydroxylates saturated fatty acids... | Q6ZWL3 |
Q6JBY9 | CPZIP_HUMAN | RCSD domain-containing protein 1 | Homo | <M><E><E><R><P><A><E><T><N><A><N><V><D><N><S><A><S><P><S><V><A><Q><L><A><G><R><F><R><E><Q><A><A><A><A><K><E><T><P><A><S><K><P><T><R><R><K><P><P><C><S><L><P><L><F><P><P><K><V><D><L><G><Q><N><G><E><E><K><S><P><P><N><A><S><H><P><P><K><F><K><V><K><S><S><P><L><I><E><K><L><Q><A><N><L><T><F><D><P><A><A><L><L><P><G><A><S><P><K... | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.<BOP> | Q6JBY9 |
Q5W0Z9 | ZDH20_HUMAN | Zinc finger DHHC domain-containing protein 20 | Homo | <M><A><P><W><T><L><W><R><C><C><Q><R><V><V><G><W><V><P><V><L><F><I><T><F><V><V><V><W><S><Y><Y><A><Y><V><V><E><L><C><V><F><T><I><F><G><N><E><E><N><G><K><T><V><V><Y><L><V><A><F><H><L><F><F><V><M><F><V><W><S><Y><W><M><T><I><F><T><S><P><A><S><P><S><K><E><F><Y><L><S><N><S><E><K><E><R><Y><E><K><E><F><S><Q><E><R><Q><Q><E><I><L... | (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biog... | Q5W0Z9 |
P47974 | TISD_HUMAN | Zinc finger protein 36, C3H1 type-like 2 | Homo | <M><S><T><T><L><L><S><A><F><Y><D><V><D><F><L><C><K><T><E><K><S><L><A><N><L><N><L><N><N><M><L><D><K><K><A><V><G><T><P><V><A><A><A><P><S><S><G><F><A><P><G><F><L><R><R><H><S><A><S><N><L><H><A><L><A><H><P><A><P><S><P><G><S><C><S><P><K><F><P><G><A><A><N><G><S><S><C><G><S><A><A><A><G><G><P><T><S><Y><G><T><L><K><E><P><S><G><G... | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis . Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to c... | P47974 |
Q8NGY5 | OR6N1_HUMAN | Olfactory receptor 6N1 | Homo | <M><D><T><G><N><W><S><Q><V><A><E><F><I><I><L><G><F><P><H><L><Q><G><V><Q><I><Y><L><F><L><L><L><L><L><I><Y><L><M><T><V><L><G><N><L><L><I><F><L><V><V><C><L><D><S><R><L><H><T><P><M><Y><H><F><V><S><I><L><S><F><S><E><L><G><Y><T><A><A><T><I><P><K><M><L><A><N><L><L><S><E><K><K><T><I><S><F><S><G><C><L><L><Q><I><Y><F><F><H><S><L... | Odorant receptor.<BOP> | Q8NGY5 |
Q9NZP5 | O5AC2_HUMAN | HSA1 | Homo | <M><D><I><S><E><G><N><K><T><L><V><T><E><F><V><L><T><G><L><T><D><R><P><W><L><H><V><L><F><F><V><V><F><L><V><V><Y><L><I><T><M><V><G><N><L><G><L><I><V><L><I><W><N><D><P><H><L><H><M><P><M><Y><L><F><L><G><G><L><A><F><S><D><A><C><T><S><T><S><I><T><P><R><M><L><V><N><F><L><D><K><T><A><M><I><S><L><A><E><C><I><T><Q><F><Y><F><F><A... | Odorant receptor.<BOP> | Q9NZP5 |
Q15761 | NPY5R_HUMAN | NPY-Y5 receptor | Homo | <M><D><L><E><L><D><E><Y><Y><N><K><T><L><A><T><E><N><N><T><A><A><T><R><N><S><D><F><P><V><W><D><D><Y><K><S><S><V><D><D><L><Q><Y><F><L><I><G><L><Y><T><F><V><S><L><L><G><F><M><G><N><L><L><I><L><M><A><L><M><K><K><R><N><Q><K><T><T><V><N><F><L><I><G><N><L><A><F><S><D><I><L><V><V><L><F><C><S><P><F><T><L><T><S><V><L><L><D><Q><W... | Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.<BOP> | Q15761 |
A8MUU1 | FB5L3_HUMAN | Fatty acid-binding protein 5 pseudogene 3 | Homo | <M><G><A><M><A><K><P><D><C><I><I><T><C><D><S><K><N><L><T><I><K><T><E><S><T><L><K><T><T><Q><F><S><G><T><L><G><E><K><F><E><E><N><T><A><D><G><R><R><T><Q><T><V><C><N><F><T><D><G><A><L><V><Q><H><Q><E><W><D><G><K><E><S><T><I><T><R><K><L><K><D><G><K><L><V><V><E><R><V><M><N><H><V><A><C><T><R><I><Y><E><K><A><Q> | High specificity for fatty acids.<BOP> | A8MUU1 |
Q96B01 | R51A1_HUMAN | RAD51-interacting protein | Homo | <M><V><R><P><V><R><H><K><K><P><V><N><Y><S><Q><F><D><H><S><D><S><D><D><D><F><V><S><A><T><V><P><L><N><K><K><S><R><T><A><P><K><E><L><K><Q><D><K><P><K><P><N><L><N><N><L><R><K><E><E><I><P><V><Q><E><K><T><P><K><K><R><L><P><E><G><T><F><S><I><P><A><S><A><V><P><C><T><K><M><A><L><D><D><K><L><Y><Q><R><D><L><E><V><A><L><A><L><S><V... | Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination . Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 . Binds single-stranded DNA (ss... | Q96B01 |
Q6IEG0 | SNR48_HUMAN | U11/U12 small nuclear ribonucleoprotein 48 kDa protein | Homo | <M><E><G><E><P><P><P><V><E><E><R><R><R><L><Q><E><E><L><N><E><F><V><E><S><G><C><R><T><L><E><E><V><T><A><S><L><G><W><D><L><D><S><L><D><P><G><E><E><E><A><A><E><D><E><V><V><I><C><P><Y><D><S><N><H><H><M><P><K><S><S><L><A><K><H><M><A><S><C><R><L><R><K><M><G><Y><T><K><E><E><E><D><E><M><Y><N><P><E><F><F><Y><E><N><V><K><I><P><S... | Likely involved in U12-type 5' splice site recognition.<BOP> | Q6IEG0 |
Q6UW10 | SFTA2_HUMAN | Surfactant-associated protein G | Homo | <M><G><S><G><L><P><L><V><L><L><L><T><L><L><G><S><S><H><G><T><G><P><G><M><T><L><Q><L><K><L><K><E><S><F><L><T><N><S><S><Y><E><S><S><F><L><E><L><L><E><K><L><C><L><L><L><H><L><P><S><G><T><S><V><T><L><H><H><A><R><S><Q><H><H><V><V><C><N><T> | Putative surfactant protein.<BOP> | Q6UW10 |
P20333 | TNR1B_HUMAN | TBPII | Homo | <M><A><P><V><A><V><W><A><A><L><A><V><G><L><E><L><W><A><A><A><H><A><L><P><A><Q><V><A><F><T><P><Y><A><P><E><P><G><S><T><C><R><L><R><E><Y><Y><D><Q><T><A><Q><M><C><C><S><K><C><S><P><G><Q><H><A><K><V><F><C><T><K><T><S><D><T><V><C><D><S><C><E><D><S><T><Y><T><Q><L><W><N><W><V><P><E><C><L><S><C><G><S><R><C><S><S><D><Q><V><E><T... | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-... | P20333 |
Q13117 | DAZ2_HUMAN | Deleted in azoospermia protein 2 | Homo | <M><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K... | RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.<BOP> | Q13117 |
Q9Y2P7 | ZN256_HUMAN | Bone marrow zinc finger 3 | Homo | <M><A><A><A><E><L><T><A><P><A><Q><G><I><V><T><F><E><D><V><A><V><Y><F><S><W><K><E><W><G><L><L><D><E><A><Q><K><C><L><Y><H><D><V><M><L><E><N><L><T><L><T><T><S><L><G><G><S><G><A><G><D><E><E><A><P><Y><Q><Q><S><T><S><P><Q><R><V><S><Q><V><R><I><P><K><A><L><P><S><P><Q><K><T><N><P><C><E><I><C><G><P><V><L><R><Q><I><L><H><L><V><E... | Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.<BOP> | Q9Y2P7 |
Q5T2E6 | ARMD3_HUMAN | Armadillo-like helical domain-containing protein 3 | Homo | <M><A><Q><V><E><K><R><G><G><L><L><R><K><S><S><A><S><K><K><P><L><K><E><K><V><V><L><M><Y><D><E><I><F><M><T><E><D><P><S><K><C><S><P><R><F><W><E><E><L><F><L><M><K><V><N><L><E><Y><L><E><G><K><L><E><S><L><D><G><E><E><L><M><K><I><K><D><N><I><N><C><L><F><Q><H><C><I><Q><A><L><G><E><E><H><P><I><R><V><V><N><A><L><Q><T><L><C><A><L... | Involved in GBF1 recruitment, Golgi maintenance and protein secretion.<BOP> | Q5T2E6 |
O14990 | IPP2C_HUMAN | Type-1 protein phosphatase inhibitor 4 | Homo | <M><S><A><S><T><S><S><H><R><P><I><K><G><I><L><K><N><K><S><S><S><G><S><S><V><A><T><S><G><Q><Q><S><G><G><T><I><Q><D><V><K><R><K><K><S><Q><K><W><D><E><S><S><I><L><A><A><H><R><A><T><Y><R><D><Y><D><L><M><K><A><N><E><P><G><T><S><Y><M><S><V><Q><D><N><G><E><D><S><V><R><D><V><E><G><E><D><S><V><R><G><V><E><G><K><E><A><T><D><A><S... | Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.<BOP> | O14990 |
Q5EBM0 | CMPK2_HUMAN | Nucleoside-diphosphate kinase | Homo | <M><A><F><A><R><R><L><L><R><G><P><L><S><G><P><L><L><G><R><R><G><V><C><A><G><A><M><A><P><P><R><R><F><V><L><E><L><P><D><C><T><L><A><H><F><A><L><G><A><D><A><P><G><D><A><D><A><P><D><P><R><L><A><A><L><L><G><P><P><E><R><S><Y><S><L><C><V><P><V><T><P><D><A><G><C><G><A><R><V><R><A><A><R><L><H><Q><R><L><L><H><Q><L><R><R><G><P><F... | May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved i... | Q5EBM0 |
Q9NRE1 | MMP26_HUMAN | Matrilysin-2 | Homo | <M><Q><L><V><I><L><R><V><T><I><F><L><P><W><C><F><A><V><P><V><P><P><A><A><D><H><K><G><W><D><F><V><E><G><Y><F><H><Q><F><F><L><T><K><K><E><S><P><L><L><T><Q><E><T><Q><T><Q><L><L><Q><Q><F><H><R><N><G><T><D><L><L><D><M><Q><M><H><A><L><L><H><Q><P><H><C><G><V><P><D><G><S><D><T><S><I><S><P><G><R><C><K><W><N><K><H><T><L><T><Y><R... | May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.<BOP> | Q9NRE1 |
Q86W34 | AMZ2_HUMAN | Archeobacterial metalloproteinase-like protein 2 | Homo | <M><Q><I><I><R><H><S><E><Q><T><L><K><T><A><L><I><S><K><N><P><V><L><V><S><Q><Y><E><K><L><N><A><G><E><Q><R><L><M><N><E><A><F><Q><P><A><S><D><L><F><G><P><I><T><L><H><S><P><S><D><W><I><T><S><H><P><E><A><P><Q><D><F><E><Q><F><F><S><D><P><Y><R><K><T><P><S><P><N><K><R><S><I><Y><I><Q><S><I><G><S><L><G><N><T><R><I><I><S><E><E><Y... | Probable zinc metalloprotease.<BOP> | Q86W34 |
Q6NXT1 | ANR54_HUMAN | Lyn-interacting ankyrin repeat protein | Homo | <M><A><A><A><A><G><D><A><D><D><E><P><R><S><G><H><S><S><S><E><G><E><C><A><V><A><P><E><P><L><T><D><A><E><G><L><F><S><F><A><D><F><G><S><A><L><G><G><G><G><A><G><L><S><G><R><A><S><G><G><A><Q><S><P><L><R><Y><L><H><V><L><W><Q><Q><D><A><E><P><R><D><E><L><R><C><K><I><P><A><G><R><L><R><R><A><A><R><P><H><R><R><L><G><P><T><G><K><E... | Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.<BOP> | Q6NXT1 |
P05109 | S10A8_HUMAN | Urinary stone protein band A | Homo | <M><L><T><E><L><E><K><A><L><N><S><I><I><D><V><Y><H><K><Y><S><L><I><K><G><N><F><H><A><V><Y><R><D><D><L><K><K><L><L><E><T><E><C><P><Q><Y><I><R><K><K><G><A><D><V><W><F><K><E><L><D><I><N><T><D><G><A><V><N><F><Q><E><F><L><I><L><V><I><K><M><G><V><A><A><H><K><K><S><H><E><E><S><H><K><E> | (Microbial infection) Upon infection by human coronavirus SARS-CoV-2, may induce expansion of aberrant immature neutrophils in a TLR4-dependent manner.<BOP> | P05109 |
P02655 | APOC2_HUMAN | Proapolipoprotein C-II | Homo | <M><G><T><R><L><L><P><A><L><F><L><V><L><L><V><L><G><F><E><V><Q><G><T><Q><Q><P><Q><Q><D><E><M><P><S><P><T><F><L><T><Q><V><K><E><S><L><S><S><Y><W><E><S><A><K><T><A><A><Q><N><L><Y><E><K><T><Y><L><P><A><V><D><E><K><L><R><D><L><Y><S><K><S><T><A><A><M><S><T><Y><T><G><I><F><T><D><Q><V><L><S><V><L><K><G><E><E> | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In... | P02655 |
P37173 | TGFR2_HUMAN | Transforming growth factor-beta receptor type II | Homo | <M><G><R><G><L><L><R><G><L><W><P><L><H><I><V><L><W><T><R><I><A><S><T><I><P><P><H><V><Q><K><S><V><N><N><D><M><I><V><T><D><N><N><G><A><V><K><F><P><Q><L><C><K><F><C><D><V><R><F><S><T><C><D><N><Q><K><S><C><M><S><N><C><S><I><T><S><I><C><E><K><P><Q><E><V><C><V><A><V><W><R><K><N><D><E><N><I><T><L><E><T><V><C><H><D><P><K><L><P... | Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.<BOP> | P37173 |
P41208 | CETN2_HUMAN | Caltractin isoform 1 | Homo | <M><A><S><N><F><K><K><A><N><M><A><S><S><S><Q><R><K><R><M><S><P><K><P><E><L><T><E><E><Q><K><Q><E><I><R><E><A><F><D><L><F><D><A><D><G><T><G><T><I><D><V><K><E><L><K><V><A><M><R><A><L><G><F><E><P><K><K><E><E><I><K><K><M><I><S><E><I><D><K><E><G><T><G><K><M><N><F><G><D><F><L><T><V><M><T><Q><K><M><S><E><K><D><T><K><E><E><I><L... | As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.<BOP> | P41208 |
Q96AH8 | RAB7B_HUMAN | Ras-related protein Rab-7b | Homo | <M><N><P><R><K><K><V><D><L><K><L><I><I><V><G><A><I><G><V><G><K><T><S><L><L><H><Q><Y><V><H><K><T><F><Y><E><E><Y><Q><T><T><L><G><A><S><I><L><S><K><I><I><I><L><G><D><T><T><L><K><L><Q><I><W><D><T><G><G><Q><E><R><F><R><S><M><V><S><T><F><Y><K><G><S><D><G><C><I><L><A><F><D><V><T><D><L><E><S><F><E><A><L><D><I><W><R><G><D><V><L... | Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysos... | Q96AH8 |
Q5M9Q1 | NKAPL_HUMAN | NKAP-like protein | Homo | <M><P><P><V><S><R><S><S><Y><S><E><D><I><V><G><S><R><R><R><R><R><S><S><S><G><S><P><P><S><P><Q><S><R><C><S><S><W><D><G><C><S><R><S><H><S><R><G><R><E><G><L><R><P><P><W><S><E><L><D><V><G><A><L><Y><P><F><S><R><S><G><S><R><G><R><L><P><R><F><R><N><Y><A><F><A><S><S><W><S><T><S><Y><S><G><Y><R><Y><H><R><H><C><Y><A><E><E><R><Q><S... | Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.<BOP> | Q5M9Q1 |
Q9H900 | ZWILC_HUMAN | Protein zwilch homolog | Homo | <M><W><E><R><L><N><C><A><A><E><D><F><Y><S><R><L><L><Q><K><F><N><E><E><K><K><G><I><R><K><D><P><F><L><Y><E><A><D><V><Q><V><Q><L><I><S><K><G><Q><P><N><P><L><K><N><I><L><N><E><N><D><I><V><F><I><V><E><K><V><P><L><E><K><E><E><T><S><H><I><E><E><L><Q><S><E><E><T><A><I><S><D><F><S><T><G><E><N><V><G><P><L><A><L><P><V><G><K><A><R... | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex .<B... | Q9H900 |
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