accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q13510
ASAH1_HUMAN
Acid ceramidase subunit beta
Homo
<M><P><G><R><S><C><V><A><L><V><L><L><A><A><A><V><S><C><A><V><A><Q><H><A><P><P><W><T><E><D><C><R><K><S><T><Y><P><P><S><G><P><T><Y><R><G><A><V><P><W><Y><T><I><N><L><D><L><P><P><Y><K><R><W><H><E><L><M><L><D><K><A><P><V><L><K><V><I><V><N><S><L><K><N><M><I><N><T><F><V><P><S><G><K><I><M><Q><V><V><D><E><K><L><P><G><L><L><G><N><F><P><G><P><F><E><E><E><M><K><G><I><A><A><V><T><D><I><P><L><G><E><I><I><S><F><N><I><F><Y><E><L><F><T><I><C><T><S><I><V><A><E><D><K><K><G><H><L><I><H><G><R><N><M><D><F><G><V><F><L><G><W><N><I><N><N><D><T><W><V><I><T><E><Q><L><K><P><L><T><V><N><L><D><F><Q><R><N><N><K><T><V><F><K><A><S><S><F><A><G><Y><V><G><M><L><T><G><F><K><P><G><L><F><S><L><T><L><N><E><R><F><S><I><N><G><G><Y><L><G><I><L><E><W><I><L><G><K><K><D><V><M><W><I><G><F><L><T><R><T><V><L><E><N><S><T><S><Y><E><E><A><K><N><L><L><T><K><T><K><I><L><A><P><A><Y><F><I><L><G><G><N><Q><S><G><E><G><C><V><I><T><R><D><R><K><E><S><L><D><V><Y><E><L><D><A><K><Q><G><R><W><Y><V><V><Q><T><N><Y><D><R><W><K><H><P><F><F><L><D><D><R><R><T><P><A><K><M><C><L><N><R><T><S><Q><E><N><I><S><F><E><T><M><Y><D><V><L><S><T><K><P><V><L><N><K><L><T><V><Y><T><T><L><I><D><V><T><K><G><Q><F><E><T><Y><L><R><D><C><P><D><P><C><I><G><W>
May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity.<BOP>
Q13510
Q2QL34
MP17L_HUMAN
M-LP homolog
Homo
<M><A><G><W><W><P><A><L><S><R><A><A><R><R><H><P><W><P><T><N><V><L><L><Y><G><S><L><V><S><A><G><D><A><L><Q><Q><R><L><Q><G><R><E><A><N><W><R><Q><T><R><R><V><A><T><L><V><V><T><F><H><A><N><F><N><Y><V><W><L><R><L><L><E><R><A><L><P><G><R><A><P><H><A><L><L><A><K><L><L><C><D><Q><V><V><G><A><P><I><A><V><S><A><F><Y><V><G><M><S><I><L><Q><G><K><D><D><I><F><L><D><L><K><Q><K><F><W><N><T><Y><L><S><G><L><M><Y><W><P><F><V><Q><L><T><N><F><S><L><V><P><V><Q><W><R><T><A><Y><A><G><V><C><G><F><L><W><A><T><F><I><C><F><S><Q><Q><S><G><D><G><T><F><K><S><A><F><T><I><L><Y><T><K><G><T><S><A><T><E><G><Y><P><K><K>
Isoform 1 participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.<BOP>
Q2QL34
Q9NVR7
TBCC1_HUMAN
TBCC domain-containing protein 1
Homo
<M><D><Q><S><R><V><L><L><W><V><K><A><E><P><F><I><V><G><A><L><Q><V><P><P><P><S><K><F><S><L><H><Y><L><R><K><I><S><T><Y><V><Q><I><R><A><T><E><G><A><Y><P><R><L><Y><W><S><T><W><R><H><I><A><C><G><K><L><Q><L><A><K><D><L><A><W><L><Y><F><E><I><F><D><S><L><S><M><K><T><P><E><E><R><L><E><W><S><E><V><L><S><N><C><M><S><E><E><E><V><E><K><Q><R><N><Q><L><S><V><D><T><L><Q><F><L><L><F><L><Y><I><Q><Q><L><N><K><V><S><L><R><T><S><L><I><G><E><E><W><P><S><P><R><N><K><S><Q><S><P><D><L><T><E><K><S><N><C><H><N><K><N><W><N><D><Y><S><H><Q><A><F><V><Y><D><H><L><S><D><L><L><E><L><L><L><D><P><K><Q><L><T><A><S><F><H><S><T><H><S><S><L><V><S><R><E><A><V><V><A><L><S><F><L><I><E><G><T><I><S><R><A><R><K><I><Y><P><L><H><E><L><A><L><W><Q><P><L><H><A><D><S><G><F><S><K><I><S><K><T><F><S><F><Y><K><L><E><T><W><L><R><S><C><L><T><G><N><P><F><G><T><S><A><C><L><K><S><G><K><K><L><A><W><A><H><Q><V><E><G><T><T><K><R><A><K><I><A><C><N><T><H><V><A><P><R><M><H><R><L><V><V><M><S><Q><V><Y><K><Q><T><L><A><K><S><S><D><T><L><A><G><A><H><V><K><I><H><R><C><N><E><S><F><I><Y><L><L><S><P><L><R><S><V><T><I><E><K><C><R><N><S><I><F><V><L><G><P><V><G><T><T><L><H><L><H><S><C><D><N><V><K><V><I><A><V><C><H><R><L><S><I><S><S><T><T><G><C><I><F><H><V><L><T><P><T><R><P><L><I><L><S><G><N><Q><T><V><T><F><A><P><F><H><T><H><Y><P><M><L><E><D><H><M><A><R><T><G><L><A><T><V><P><N><Y><W><D><N><P><M><V><V><C><R><E><N><S><D><T><R><V><F><Q><L><L><P><P><C><E><F><Y><V><F><I><I><P><F><E><M><E><G><D><T><T><E><I><P><G><G><L><P><S><V><Y><Q><K><A><L><G><Q><R><E><Q><K><I><Q><I><W><Q><K><T><V><K><E><A><H><L><T><K><D><Q><R><K><Q><F><Q><V><L><V><E><N><K><F><Y><E><W><L><I><N><T><G><H><R><Q><Q><L><D><S><L><V><P><P><A><A><G><S><K><Q><A><A><G>
Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.<BOP>
Q9NVR7
Q96HF1
SFRP2_HUMAN
Secreted apoptosis-related protein 1
Homo
<M><L><Q><G><P><G><S><L><L><L><L><F><L><A><S><H><C><C><L><G><S><A><R><G><L><F><L><F><G><Q><P><D><F><S><Y><K><R><S><N><C><K><P><I><P><A><N><L><Q><L><C><H><G><I><E><Y><Q><N><M><R><L><P><N><L><L><G><H><E><T><M><K><E><V><L><E><Q><A><G><A><W><I><P><L><V><M><K><Q><C><H><P><D><T><K><K><F><L><C><S><L><F><A><P><V><C><L><D><D><L><D><E><T><I><Q><P><C><H><S><L><C><V><Q><V><K><D><R><C><A><P><V><M><S><A><F><G><F><P><W><P><D><M><L><E><C><D><R><F><P><Q><D><N><D><L><C><I><P><L><A><S><S><D><H><L><L><P><A><T><E><E><A><P><K><V><C><E><A><C><K><N><K><N><D><D><D><N><D><I><M><E><T><L><C><K><N><D><F><A><L><K><I><K><V><K><E><I><T><Y><I><N><R><D><T><K><I><I><L><E><T><K><S><K><T><I><Y><K><L><N><G><V><S><E><R><D><L><K><K><S><V><L><W><L><K><D><S><L><Q><C><T><C><E><E><M><N><D><I><N><A><P><Y><L><V><M><G><Q><K><Q><G><G><E><L><V><I><T><S><V><K><R><W><Q><K><G><Q><R><E><F><K><R><I><S><R><S><I><R><K><L><Q><C>
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.<BOP>
Q96HF1
Q5U5Q3
MEX3C_HUMAN
RING-type E3 ubiquitin transferase MEX3C
Homo
<M><P><S><G><S><S><A><A><L><A><L><A><A><A><P><A><P><L><P><Q><P><P><P><P><P><P><P><P><P><P><P><L><P><P><P><S><G><G><P><E><L><E><G><D><G><L><L><L><R><E><R><L><A><A><L><G><L><D><D><P><S><P><A><E><P><G><A><P><A><L><R><A><P><A><A><A><A><Q><G><Q><A><R><R><A><A><E><L><S><P><E><E><R><A><P><P><G><R><P><G><A><P><E><A><A><E><L><E><L><E><E><D><E><E><E><G><E><E><A><E><L><D><G><D><L><L><E><E><E><E><L><E><E><A><E><E><E><D><R><S><S><L><L><L><L><S><P><P><A><A><T><A><S><Q><T><Q><Q><I><P><G><G><S><L><G><S><V><L><L><P><A><A><R><F><D><A><R><E><A><A><A><A><A><A><A><A><G><V><L><Y><G><G><D><D><A><Q><G><M><M><A><A><M><L><S><H><A><Y><G><P><G><G><C><G><A><A><A><A><A><L><N><G><E><Q><A><A><L><L><R><R><K><S><V><N><T><T><E><C><V><P><V><P><S><S><E><H><V><A><E><I><V><G><R><Q><G><C><K><I><K><A><L><R><A><K><T><N><T><Y><I><K><T><P><V><R><G><E><E><P><I><F><V><V><T><G><R><K><E><D><V><A><M><A><K><R><E><I><L><S><A><A><E><H><F><S><M><I><R><A><S><R><N><K><N><G><P><A><L><G><G><L><S><C><S><P><N><L><P><G><Q><T><T><V><Q><V><R><V><P><Y><R><V><V><G><L><V><V><G><P><K><G><A><T><I><K><R><I><Q><Q><Q><T><H><T><Y><I><V><T><P><S><R><D><K><E><P><V><F><E><V><T><G><M><P><E><N><V><D><R><A><R><E><E><I><E><M><H><I><A><M><R><T><G><N><Y><I><E><L><N><E><E><N><D><F><H><Y><N><G><T><D><V><S><F><E><G><G><T><L><G><S><A><W><L><S><S><N><P><V><P><P><S><R><A><R><M><I><S><N><Y><R><N><D><S><S><S><S><L><G><S><G><S><T><D><S><Y><F><G><S><N><R><L><A><D><F><S><P><T><S><P><F><S><T><G><N><F><W><F><G><D><T><L><P><S><V><G><S><E><D><L><A><V><D><S><P><A><F><D><S><L><P><T><S><A><Q><T><I><W><T><P><F><E><P><V><N><P><L><S><G><F><G><S><D><P><S><G><N><M><K><T><Q><R><R><G><S><Q><P><S><T><P><R><L><S><P><T><F><P><E><S><I><E><H><P><L><A><R><R><V><R><S><D><P><P><S><T><G><N><H><V><G><L><P><I><Y><I><P><A><F><S><N><G><T><N><S><Y><S><S><S><N><G><G><S><T><S><S><S><P><P><E><S><R><R><K><H><D><C><V><I><C><F><E><N><E><V><I><A><A><L><V><P><C><G><H><N><L><F><C><M><E><C><A><N><K><I><C><E><K><R><T><P><S><C><P><V><C><Q><T><A><V><T><Q><A><I><Q><I><H><S>
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.<BOP>
Q5U5Q3
P22532
SPR2D_HUMAN
Small proline-rich protein II
Homo
<M><S><Y><Q><Q><Q><Q><C><K><Q><P><C><Q><P><P><P><V><C><P><T><P><K><C><P><E><P><C><P><P><P><K><C><P><E><P><C><P><S><P><K><C><P><Q><P><C><P><P><Q><Q><C><Q><Q><K><Y><P><P><V><T><P><S><P><P><C><Q><P><K><C><P><P><K><S><K>
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.<BOP>
P22532
O43167
ZBT24_HUMAN
Zinc finger protein 450
Homo
<M><A><E><T><S><P><E><P><S><G><Q><L><V><V><H><S><D><A><H><S><D><T><V><L><A><S><F><E><D><Q><R><K><K><G><F><L><C><D><I><T><L><I><V><E><N><V><H><F><R><A><H><K><A><L><L><A><A><S><S><E><Y><F><S><M><M><F><A><E><E><G><E><I><G><Q><S><I><Y><M><L><E><G><M><V><A><D><T><F><G><I><L><L><E><F><I><Y><T><G><Y><L><H><A><S><E><K><S><T><E><Q><I><L><A><T><A><Q><F><L><K><V><Y><D><L><V><K><A><Y><T><D><F><Q><N><N><H><S><S><P><K><P><T><T><L><N><T><A><G><A><P><V><V><V><I><S><N><K><K><N><D><P><P><K><R><K><R><G><R><P><K><K><V><N><T><L><Q><E><E><K><S><E><L><A><A><E><E><E><I><Q><L><R><V><N><N><S><V><Q><N><R><Q><N><F><V><V><K><G><D><S><G><V><L><N><E><Q><I><A><A><K><E><K><E><E><S><E><P><T><C><E><P><S><R><E><E><E><M><P><V><E><K><D><E><N><Y><D><P><K><T><E><D><G><Q><A><S><Q><S><R><Y><S><K><R><R><I><W><R><S><V><K><L><K><D><Y><K><L><V><G><D><Q><E><D><H><G><S><A><K><R><I><C><G><R><R><K><R><P><G><G><P><E><A><R><C><K><D><C><G><K><V><F><K><Y><N><H><F><L><A><I><H><Q><R><S><H><T><G><E><R><P><F><K><C><N><E><C><G><K><G><F><A><Q><K><H><S><L><Q><V><H><T><R><M><H><T><G><E><R><P><Y><T><C><T><V><C><S><K><A><L><T><T><K><H><S><L><L><E><H><M><S><L><H><S><G><Q><K><S><F><T><C><D><Q><C><G><K><Y><F><S><Q><N><R><Q><L><K><S><H><Y><R><V><H><T><G><H><S><L><P><E><C><K><D><C><H><R><K><F><M><D><V><S><Q><L><K><K><H><L><R><T><H><T><G><E><K><P><F><T><C><E><I><C><G><K><S><F><T><A><K><S><S><L><Q><T><H><I><R><I><H><R><G><E><K><P><Y><S><C><G><I><C><G><K><S><F><S><D><S><S><A><K><R><R><H><C><I><L><H><T><G><K><K><P><F><S><C><P><E><C><N><L><Q><F><A><R><L><D><N><L><K><A><H><L><K><I><H><S><K><E><K><H><A><S><D><A><S><S><I><S><G><S><S><N><T><E><E><V><R><N><I><L><Q><L><Q><P><Y><Q><L><S><T><S><G><E><Q><E><I><Q><L><L><V><T><D><S><V><H><N><I><N><F><M><P><G><P><S><Q><G><I><S><I><V><T><A><E><S><S><Q><N><M><T><A><D><Q><A><A><N><L><T><L><L><T><Q><Q><P><E><Q><L><Q><N><L><I><L><S><A><Q><Q><E><Q><T><E><H><I><Q><S><L><N><M><I><E><S><Q><M><G><P><S><Q><T><E><P><V><H><V><I><T><L><S><K><E><T><L><E><H><L><H><A><H><Q><E><Q><T><E><E><L><H><L><A><T><S><T><S><D><P><A><Q><H><L><Q><L><T><Q><E><P><G><P><P><P><P><T><H><H><V><P><Q><P><T><P><L><G><Q><E><Q><S>
May be involved in BMP2-induced transcription.<BOP>
O43167
P24863
CCNC_HUMAN
SRB11 homolog
Homo
<M><A><G><N><F><W><Q><S><S><H><Y><L><Q><W><I><L><D><K><Q><D><L><L><K><E><R><Q><K><D><L><K><F><L><S><E><E><E><Y><W><K><L><Q><I><F><F><T><N><V><I><Q><A><L><G><E><H><L><K><L><R><Q><Q><V><I><A><T><A><T><V><Y><F><K><R><F><Y><A><R><Y><S><L><K><S><I><D><P><V><L><M><A><P><T><C><V><F><L><A><S><K><V><E><E><F><G><V><V><S><N><T><R><L><I><A><A><A><T><S><V><L><K><T><R><F><S><Y><A><F><P><K><E><F><P><Y><R><M><N><H><I><L><E><C><E><F><Y><L><L><E><L><M><D><C><C><L><I><V><Y><H><P><Y><R><P><L><L><Q><Y><V><Q><D><M><G><Q><E><D><M><L><L><P><L><A><W><R><I><V><N><D><T><Y><R><T><D><L><C><L><L><Y><P><P><F><M><I><A><L><A><C><L><H><V><A><C><V><V><Q><Q><K><D><A><R><Q><W><F><A><E><L><S><V><D><M><E><K><I><L><E><I><I><R><V><I><L><K><L><Y><E><Q><W><K><N><F><D><E><R><K><E><M><A><T><I><L><S><K><M><P><K><P><K><P><P><P><N><S><E><G><E><Q><G><P><N><G><S><Q><N><S><S><Y><S><Q><S>
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.<BOP>
P24863
Q8IYP9
ZDH23_HUMAN
Zinc finger DHHC domain-containing protein 23
Homo
<M><T><Q><K><G><S><M><K><P><V><K><K><K><K><T><E><E><P><E><L><E><P><L><C><C><C><E><Y><I><D><R><N><G><E><K><N><H><V><A><T><C><L><C><D><C><Q><D><L><D><E><G><C><D><R><W><I><T><C><K><S><L><Q><P><E><T><C><E><R><I><M><D><T><I><S><D><R><L><R><I><P><W><L><R><G><A><K><K><V><N><I><S><I><I><P><P><L><V><L><L><P><V><F><L><H><V><A><S><W><H><F><L><L><G><V><V><V><L><T><S><L><P><V><L><A><L><W><Y><Y><Y><L><T><H><R><R><K><E><Q><T><L><F><F><L><S><L><G><L><F><S><L><G><Y><M><Y><Y><V><F><L><Q><E><V><V><P><K><G><R><V><G><P><V><Q><L><A><V><L><T><C><G><L><F><L><I><L><L><A><L><H><R><A><K><K><N><P><G><Y><L><S><N><P><A><S><G><D><R><S><L><S><S><S><Q><L><E><C><L><S><R><K><G><Q><E><K><T><K><G><F><P><G><A><D><M><S><G><S><L><N><N><R><T><T><K><D><D><P><K><G><S><S><K><M><P><A><G><S><P><T><K><A><K><E><D><W><C><A><K><C><Q><L><V><R><P><A><R><A><W><H><C><R><I><C><G><I><C><V><R><R><M><D><H><H><C><V><W><I><N><S><C><V><G><E><S><N><H><Q><A><F><I><L><A><L><L><I><F><L><L><T><S><V><Y><G><I><T><L><T><L><D><T><I><C><R><D><R><S><V><F><T><A><L><F><Y><C><P><G><V><Y><A><N><Y><S><S><A><L><S><F><T><C><V><W><Y><S><V><I><I><T><A><G><M><A><Y><I><F><L><I><Q><L><I><N><I><S><Y><N><V><T><E><R><E><V><Q><Q><A><L><R><Q><K><T><G><R><R><L><L><C><G><L><I><V><D><T><G><L><L><G>
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.<BOP>
Q8IYP9
P46976
GLYG_HUMAN
Glycogenin-1
Homo
<M><T><D><Q><A><F><V><T><L><T><T><N><D><A><Y><A><K><G><A><L><V><L><G><S><S><L><K><Q><H><R><T><T><R><R><L><V><V><L><A><T><P><Q><V><S><D><S><M><R><K><V><L><E><T><V><F><D><E><V><I><M><V><D><V><L><D><S><G><D><S><A><H><L><T><L><M><K><R><P><E><L><G><V><T><L><T><K><L><H><C><W><S><L><T><Q><Y><S><K><C><V><F><M><D><A><D><T><L><V><L><A><N><I><D><D><L><F><D><R><E><E><L><S><A><A><P><D><P><G><W><P><D><C><F><N><S><G><V><F><V><Y><Q><P><S><V><E><T><Y><N><Q><L><L><H><L><A><S><E><Q><G><S><F><D><G><G><D><Q><G><I><L><N><T><F><F><S><S><W><A><T><T><D><I><R><K><H><L><P><F><I><Y><N><L><S><S><I><S><I><Y><S><Y><L><P><A><F><K><V><F><G><A><S><A><K><V><V><H><F><L><G><R><V><K><P><W><N><Y><T><Y><D><P><K><T><K><S><V><K><S><E><A><H><D><P><N><M><T><H><P><E><F><L><I><L><W><W><N><I><F><T><T><N><V><L><P><L><L><Q><Q><F><G><L><V><K><D><T><C><S><Y><V><N><V><L><S><D><L><V><Y><T><L><A><F><S><C><G><F><C><R><K><E><D><V><S><G><A><I><S><H><L><S><L><G><E><I><P><A><M><A><Q><P><F><V><S><S><E><E><R><K><E><R><W><E><Q><G><Q><A><D><Y><M><G><A><D><S><F><D><N><I><K><R><K><L><D><T><Y><L><Q>
Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase.<BOP>
P46976
Q9HB71
CYBP_HUMAN
Siah-interacting protein
Homo
<M><A><S><E><E><L><Q><K><D><L><E><E><V><K><V><L><L><E><K><A><T><R><K><R><V><R><D><A><L><T><A><E><K><S><K><I><E><T><E><I><K><N><K><M><Q><Q><K><S><Q><K><K><A><E><L><L><D><N><E><K><P><A><A><V><V><A><P><I><T><T><G><Y><T><V><K><I><S><N><Y><G><W><D><Q><S><D><K><F><V><K><I><Y><I><T><L><T><G><V><H><Q><V><P><T><E><N><V><Q><V><H><F><T><E><R><S><F><D><L><L><V><K><N><L><N><G><K><S><Y><S><M><I><V><N><N><L><L><K><P><I><S><V><E><G><S><S><K><K><V><K><T><D><T><V><L><I><L><C><R><K><K><V><E><N><T><R><W><D><Y><L><T><Q><V><E><K><E><C><K><E><K><E><K><P><S><Y><D><T><E><T><D><P><S><E><G><L><M><N><V><L><K><K><I><Y><E><D><G><D><D><D><M><K><R><T><I><N><K><A><W><V><E><S><R><E><K><Q><A><K><G><D><T><E><F>
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<BOP>
Q9HB71
Q96E14
RMI2_HUMAN
BLM-associated protein of 18 kDa
Homo
<M><A><A><A><A><D><S><F><S><G><G><P><A><G><V><R><L><P><R><S><P><P><L><K><V><L><A><E><Q><L><R><R><D><A><E><G><G><P><G><A><W><R><L><S><R><A><A><A><G><R><G><P><L><D><L><A><A><V><W><M><Q><G><R><V><V><M><A><D><R><G><E><A><R><L><R><D><P><S><G><D><F><S><V><R><G><L><E><R><V><P><R><G><R><P><C><L><V><P><G><K><Y><V><M><V><M><G><V><V><Q><A><C><S><P><E><P><C><L><Q><A><V><K><M><T><D><L><S><D><N><P><I><H><E><S><M><W><E><L><E><V><E><D><L><H><R><N><I><P>
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.<BOP>
Q96E14
Q06136
KDSR_HUMAN
Short chain dehydrogenase/reductase family 35C member 1
Homo
<M><L><L><L><A><A><A><F><L><V><A><F><V><L><L><L><Y><M><V><S><P><L><I><S><P><K><P><L><A><L><P><G><A><H><V><V><V><T><G><G><S><S><G><I><G><K><C><I><A><I><E><C><Y><K><Q><G><A><F><I><T><L><V><A><R><N><E><D><K><L><L><Q><A><K><K><E><I><E><M><H><S><I><N><D><K><Q><V><V><L><C><I><S><V><D><V><S><Q><D><Y><N><Q><V><E><N><V><I><K><Q><A><Q><E><K><L><G><P><V><D><M><L><V><N><C><A><G><M><A><V><S><G><K><F><E><D><L><E><V><S><T><F><E><R><L><M><S><I><N><Y><L><G><S><V><Y><P><S><R><A><V><I><T><T><M><K><E><R><R><V><G><R><I><V><F><V><S><S><Q><A><G><Q><L><G><L><F><G><F><T><A><Y><S><A><S><K><F><A><I><R><G><L><A><E><A><L><Q><M><E><V><K><P><Y><N><V><Y><I><T><V><A><Y><P><P><D><T><D><T><P><G><F><A><E><E><N><R><T><K><P><L><E><T><R><L><I><S><E><T><T><S><V><C><K><P><E><Q><V><A><K><Q><I><V><K><D><A><I><Q><G><N><F><N><S><S><L><G><S><D><G><Y><M><L><S><A><L><T><C><G><M><A><P><V><T><S><I><T><E><G><L><Q><Q><V><V><T><M><G><L><F><R><T><I><A><L><F><Y><L><G><S><F><D><S><I><V><R><R><C><M><M><Q><R><E><K><S><E><N><A><D><K><T><A>
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).<BOP>
Q06136
P28328
PEX2_HUMAN
RING finger protein 72
Homo
<M><A><S><R><K><E><N><A><K><S><A><N><R><V><L><R><I><S><Q><L><D><A><L><E><L><N><K><A><L><E><Q><L><V><W><S><Q><F><T><Q><C><F><H><G><F><K><P><G><L><L><A><R><F><E><P><E><V><K><A><C><L><W><V><F><L><W><R><F><T><I><Y><S><K><N><A><T><V><G><Q><S><V><L><N><I><K><Y><K><N><D><F><S><P><N><L><R><Y><Q><P><P><S><K><N><Q><K><I><W><Y><A><V><C><T><I><G><G><R><W><L><E><E><R><C><Y><D><L><F><R><N><H><H><L><A><S><F><G><K><V><K><Q><C><V><N><F><V><I><G><L><L><K><L><G><G><L><I><N><F><L><I><F><L><Q><R><G><K><F><A><T><L><T><E><R><L><L><G><I><H><S><V><F><C><K><P><Q><N><I><C><E><V><G><F><E><Y><M><N><R><E><L><L><W><H><G><F><A><E><F><L><I><F><L><L><P><L><I><N><V><Q><K><L><K><A><K><L><S><S><W><C><I><P><L><T><G><A><P><N><S><D><N><T><L><A><T><S><G><K><E><C><A><L><C><G><E><W><P><T><M><P><H><T><I><G><C><E><H><I><F><C><Y><F><C><A><K><S><S><F><L><F><D><V><Y><F><T><C><P><K><C><G><T><E><V><H><S><L><Q><P><L><K><S><G><I><E><M><S><E><V><N><A><L>
Somewhat implicated in the biogenesis of peroxisomes.<BOP>
P28328
Q9NPJ8
NXT2_HUMAN
Protein p15-2
Homo
<M><A><T><S><L><D><F><K><T><Y><V><D><Q><A><C><R><A><A><E><E><F><V><N><I><Y><Y><E><T><M><D><K><R><R><R><A><L><T><R><L><Y><L><D><K><A><T><L><I><W><N><G><N><A><V><S><G><L><D><A><L><N><N><F><F><D><T><L><P><S><S><E><F><Q><V><N><M><L><D><C><Q><P><V><H><E><Q><A><T><Q><S><Q><T><T><V><L><V><V><T><S><G><T><V><K><F><D><G><N><K><Q><H><F><F><N><Q><N><F><L><L><T><A><Q><S><T><P><N><N><T><V><W><K><I><A><S><D><C><F><R><F><Q><D><W><S><S><S>
Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.<BOP>
Q9NPJ8
Q00LT1
PRCD_HUMAN
Progressive rod-cone degeneration protein
Homo
<M><C><T><T><L><F><L><L><S><T><L><A><M><L><W><R><R><R><F><A><N><R><V><Q><P><E><P><S><D><V><D><G><A><A><R><G><S><S><L><D><A><D><P><Q><S><S><G><R><E><K><E><P><L><K>
Involved in vision.<BOP>
Q00LT1
Q6UX41
BTNL8_HUMAN
Butyrophilin-like protein 8
Homo
<M><A><L><M><L><S><L><V><L><S><L><L><K><L><G><S><G><Q><W><Q><V><F><G><P><D><K><P><V><Q><A><L><V><G><E><D><A><A><F><S><C><F><L><S><P><K><T><N><A><E><A><M><E><V><R><F><F><R><G><Q><F><S><S><V><V><H><L><Y><R><D><G><K><D><Q><P><F><M><Q><M><P><Q><Y><Q><G><R><T><K><L><V><K><D><S><I><A><E><G><R><I><S><L><R><L><E><N><I><T><V><L><D><A><G><L><Y><G><C><R><I><S><S><Q><S><Y><Y><Q><K><A><I><W><E><L><Q><V><S><A><L><G><S><V><P><L><I><S><I><T><G><Y><V><D><R><D><I><Q><L><L><C><Q><S><S><G><W><F><P><R><P><T><A><K><W><K><G><P><Q><G><Q><D><L><S><T><D><S><R><T><N><R><D><M><H><G><L><F><D><V><E><I><S><L><T><V><Q><E><N><A><G><S><I><S><C><S><M><R><H><A><H><L><S><R><E><V><E><S><R><V><Q><I><G><D><T><F><F><E><P><I><S><W><H><L><A><T><K><V><L><G><I><L><C><C><G><L><F><F><G><I><V><G><L><K><I><F><F><S><K><F><Q><W><K><I><Q><A><E><L><D><W><R><R><K><H><G><Q><A><E><L><R><D><A><R><K><H><A><V><E><V><T><L><D><P><E><T><A><H><P><K><L><C><V><S><D><L><K><T><V><T><H><R><K><A><P><Q><E><V><P><H><S><E><K><R><F><T><R><K><S><V><V><A><S><Q><S><F><Q><A><G><K><H><Y><W><E><V><D><G><G><H><N><K><R><W><R><V><G><V><C><R><D><D><V><D><R><R><K><E><Y><V><T><L><S><P><D><H><G><Y><W><V><L><R><L><N><G><E><H><L><Y><F><T><L><N><P><R><F><I><S><V><F><P><R><T><P><P><T><K><I><G><V><F><L><D><Y><E><C><G><T><I><S><F><F><N><I><N><D><Q><S><L><I><Y><T><L><T><C><R><F><E><G><L><L><R><P><Y><I><E><Y><P><S><Y><N><E><Q><N><G><T><P><I><V><I><C><P><V><T><Q><E><S><E><K><E><A><S><W><Q><R><A><S><A><I><P><E><T><S><N><S><E><S><S><S><Q><A><T><T><P><F><L><P><R><G><E><M>
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.<BOP>
Q6UX41
P30740
ILEU_HUMAN
Serpin B1
Homo
<M><E><Q><L><S><S><A><N><T><R><F><A><L><D><L><F><L><A><L><S><E><N><N><P><A><G><N><I><F><I><S><P><F><S><I><S><S><A><M><A><M><V><F><L><G><T><R><G><N><T><A><A><Q><L><S><K><T><F><H><F><N><T><V><E><E><V><H><S><R><F><Q><S><L><N><A><D><I><N><K><R><G><A><S><Y><I><L><K><L><A><N><R><L><Y><G><E><K><T><Y><N><F><L><P><E><F><L><V><S><T><Q><K><T><Y><G><A><D><L><A><S><V><D><F><Q><H><A><S><E><D><A><R><K><T><I><N><Q><W><V><K><G><Q><T><E><G><K><I><P><E><L><L><A><S><G><M><V><D><N><M><T><K><L><V><L><V><N><A><I><Y><F><K><G><N><W><K><D><K><F><M><K><E><A><T><T><N><A><P><F><R><L><N><K><K><D><R><K><T><V><K><M><M><Y><Q><K><K><K><F><A><Y><G><Y><I><E><D><L><K><C><R><V><L><E><L><P><Y><Q><G><E><E><L><S><M><V><I><L><L><P><D><D><I><E><D><E><S><T><G><L><K><K><I><E><E><Q><L><T><L><E><K><L><H><E><W><T><K><P><E><N><L><D><F><I><E><V><N><V><S><L><P><R><F><K><L><E><E><S><Y><T><L><N><S><D><L><A><R><L><G><V><Q><D><L><F><N><S><S><K><A><D><L><S><G><M><S><G><A><R><D><I><F><I><S><K><I><V><H><K><S><F><V><E><V><N><E><E><G><T><E><A><A><A><A><T><A><G><I><A><T><F><C><M><L><M><P><E><E><N><F><T><A><D><H><P><F><L><F><F><I><R><H><N><S><S><G><S><I><L><F><L><G><R><F><S><S><P>
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis . Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 . Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity . During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation . When secreted, promotes the proliferation of beta-cells via its protease inhibitory function .<BOP>
P30740
Q8N441
FGRL1_HUMAN
Fibroblast growth factor receptor 5
Homo
<M><T><P><S><P><L><L><L><L><L><L><P><P><L><L><L><G><A><F><P><P><A><A><A><A><R><G><P><P><K><M><A><D><K><V><V><P><R><Q><V><A><R><L><G><R><T><V><R><L><Q><C><P><V><E><G><D><P><P><P><L><T><M><W><T><K><D><G><R><T><I><H><S><G><W><S><R><F><R><V><L><P><Q><G><L><K><V><K><Q><V><E><R><E><D><A><G><V><Y><V><C><K><A><T><N><G><F><G><S><L><S><V><N><Y><T><L><V><V><L><D><D><I><S><P><G><K><E><S><L><G><P><D><S><S><S><G><G><Q><E><D><P><A><S><Q><Q><W><A><R><P><R><F><T><Q><P><S><K><M><R><R><R><V><I><A><R><P><V><G><S><S><V><R><L><K><C><V><A><S><G><H><P><R><P><D><I><T><W><M><K><D><D><Q><A><L><T><R><P><E><A><A><E><P><R><K><K><K><W><T><L><S><L><K><N><L><R><P><E><D><S><G><K><Y><T><C><R><V><S><N><R><A><G><A><I><N><A><T><Y><K><V><D><V><I><Q><R><T><R><S><K><P><V><L><T><G><T><H><P><V><N><T><T><V><D><F><G><G><T><T><S><F><Q><C><K><V><R><S><D><V><K><P><V><I><Q><W><L><K><R><V><E><Y><G><A><E><G><R><H><N><S><T><I><D><V><G><G><Q><K><F><V><V><L><P><T><G><D><V><W><S><R><P><D><G><S><Y><L><N><K><L><L><I><T><R><A><R><Q><D><D><A><G><M><Y><I><C><L><G><A><N><T><M><G><Y><S><F><R><S><A><F><L><T><V><L><P><D><P><K><P><P><G><P><P><V><A><S><S><S><S><A><T><S><L><P><W><P><V><V><I><G><I><P><A><G><A><V><F><I><L><G><T><L><L><L><W><L><C><Q><A><Q><K><K><P><C><T><P><A><P><A><P><P><L><P><G><H><R><P><P><G><T><A><R><D><R><S><G><D><K><D><L><P><S><L><A><A><L><S><A><G><P><G><V><G><L><C><E><E><H><G><S><P><A><A><P><Q><H><L><L><G><P><G><P><V><A><G><P><K><L><Y><P><K><L><Y><T><D><I><H><T><H><T><H><T><H><S><H><T><H><S><H><V><E><G><K><V><H><Q><H><I><H><Y><Q><C>
Has a negative effect on cell proliferation.<BOP>
Q8N441
Q14943
KI3S1_HUMAN
Natural killer-associated transcript 10
Homo
<M><L><L><M><V><V><S><M><A><C><V><G><L><F><L><V><Q><R><A><G><P><H><M><G><G><Q><D><K><P><F><L><S><A><W><P><S><A><V><V><P><R><G><G><H><V><T><L><R><C><H><Y><R><H><R><F><N><N><F><M><L><Y><K><E><D><R><I><H><V><P><I><F><H><G><R><I><F><Q><E><G><F><N><M><S><P><V><T><T><A><H><A><G><N><Y><T><C><R><G><S><H><P><H><S><P><T><G><W><S><A><P><S><N><P><M><V><I><M><V><T><G><N><H><R><K><P><S><L><L><A><H><P><G><P><L><V><K><S><G><E><R><V><I><L><Q><C><W><S><D><I><M><F><E><H><F><F><L><H><R><E><W><I><S><K><D><P><S><R><L><V><G><Q><I><H><D><G><V><S><K><A><N><F><S><I><G><S><M><M><R><A><L><A><G><T><Y><R><C><Y><G><S><V><T><H><T><P><Y><Q><L><S><A><P><S><D><P><L><D><I><V><V><T><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><K><V><Q><A><G><E><S><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><G><A><H><E><R><R><L><P><A><V><R><K><V><N><R><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><H><S><P><Y><E><W><S><D><P><S><D><P><L><L><V><S><V><T><G><N><P><S><S><S><W><P><S><P><T><E><P><S><S><K><S><G><N><L><R><H><L><H><I><L><I><G><T><S><V><V><K><I><P><F><T><I><L><L><F><F><L><L><H><R><W><C><S><N><K><K><K><C><C><C><N><G><P><R><A><C><R><E><Q><K>
Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.<BOP>
Q14943
Q8NGE5
O10A7_HUMAN
Olfactory receptor OR12-6
Homo
<M><I><C><E><N><H><T><R><V><T><E><F><I><L><L><G><F><T><N><N><P><E><M><Q><V><S><L><F><I><F><F><L><A><I><Y><T><V><T><L><L><G><N><F><L><I><V><T><V><T><S><V><D><L><A><L><Q><T><P><M><Y><F><F><L><Q><N><L><S><L><L><E><V><C><F><T><L><V><M><V><P><K><M><L><V><D><L><V><S><P><R><K><I><I><S><F><V><G><C><G><T><Q><M><Y><F><F><F><F><F><G><S><S><E><C><F><L><L><S><M><M><A><Y><D><R><F><V><A><I><C><N><P><L><H><Y><S><V><I><M><N><R><S><L><C><L><W><M><A><I><G><S><W><M><S><G><V><P><V><S><M><L><Q><T><A><W><M><M><A><L><P><F><C><G><P><N><A><V><D><H><F><F><C><D><G><P><P><V><L><K><L><V><T><V><D><T><T><M><Y><E><M><Q><A><L><A><S><T><L><L><F><I><M><F><P><F><C><L><I><L><V><S><Y><T><R><I><I><I><T><I><L><R><M><S><S><A><T><G><R><Q><K><A><F><S><T><C><S><S><H><L><I><V><V><S><L><F><Y><G><T><A><S><L><T><Y><L><R><P><K><S><N><Q><S><P><E><S><K><K><L><V><S><L><S><Y><T><V><I><T><P><M><L><N><P><I><I><Y><G><L><R><N><N><E><V><K><G><A><V><K><R><T><I><T><Q><K><V><L><Q><K><L><D><V><F>
Odorant receptor.<BOP>
Q8NGE5
Q9HC44
GPBL1_HUMAN
GC-rich promoter-binding protein 1-like 1
Homo
<M><A><Q><H><D><F><V><P><A><W><L><N><F><S><T><P><Q><S><A><K><S><P><T><A><T><F><E><K><H><G><E><H><L><P><R><G><E><G><R><F><G><V><S><R><R><R><H><N><S><S><D><G><F><F><N><N><G><P><L><R><T><A><G><D><S><W><H><Q><P><S><L><F><R><H><D><S><V><D><S><G><V><S><K><G><A><Y><A><G><I><T><G><N><P><S><G><W><H><S><S><S><R><G><H><D><G><M><S><Q><R><S><G><G><G><T><G><N><H><R><H><W><N><G><S><F><H><S><R><K><G><C><A><F><Q><E><K><P><P><M><E><I><R><E><E><K><K><E><D><K><V><E><K><L><Q><F><E><E><E><D><F><P><S><L><N><P><E><A><G><K><Q><H><Q><P><C><R><P><I><G><T><P><S><G><V><W><E><N><P><P><S><A><K><Q><P><S><K><M><L><V><I><K><K><V><S><K><E><D><P><A><A><A><F><S><A><A><F><T><S><P><G><S><H><H><A><N><G><N><K><L><S><S><V><V><P><S><V><Y><K><N><L><V><P><K><P><V><P><P><P><S><K><P><N><A><W><K><A><N><R><M><E><H><K><S><G><S><L><S><S><S><R><E><S><A><F><T><S><P><I><S><V><T><K><P><V><V><L><A><S><G><A><A><L><S><S><P><K><E><S><P><S><S><T><T><P><P><I><E><I><S><S><S><R><L><T><K><L><T><R><R><T><T><D><R><K><S><E><F><L><K><T><L><K><D><D><R><N><G><D><F><S><E><N><R><D><C><D><K><L><E><D><L><E><D><N><S><T><P><E><P><K><E><N><G><E><E><G><C><H><Q><N><G><L><A><L><P><V><V><E><E><G><E><V><L><S><H><S><L><E><A><E><H><R><L><L><K><A><M><G><W><Q><E><Y><P><E><N><D><E><N><C><L><P><L><T><E><D><E><L><K><E><F><H><M><K><T><E><Q><L><R><R><N><G><F><G><K><N><G><F><L><Q><S><R><S><S><S><L><F><S><P><W><R><S><T><C><K><A><E><F><E><D><S><D><T><E><T><S><S><S><E><T><S><D><D><D><A><W><K>
Possible transcription factor.<BOP>
Q9HC44
P06028
GLPB_HUMAN
Sialoglycoprotein delta
Homo
<M><Y><G><K><I><I><F><V><L><L><L><S><E><I><V><S><I><S><A><L><S><T><T><E><V><A><M><H><T><S><T><S><S><S><V><T><K><S><Y><I><S><S><Q><T><N><G><E><T><G><Q><L><V><H><R><F><T><V><P><A><P><V><V><I><I><L><I><I><L><C><V><M><A><G><I><I><G><T><I><L><L><I><S><Y><S><I><R><R><L><I><K><A>
This protein is a minor sialoglycoprotein in erythrocyte membranes.<BOP>
P06028
Q96LB2
MRGX1_HUMAN
Sensory neuron-specific G-protein coupled receptor 3/4
Homo
<M><D><P><T><I><S><T><L><D><T><E><L><T><P><I><N><G><T><E><E><T><L><C><Y><K><Q><T><L><S><L><T><V><L><T><C><I><V><S><L><V><G><L><T><G><N><A><V><V><L><W><L><L><G><C><R><M><R><R><N><A><F><S><I><Y><I><L><N><L><A><A><A><D><F><L><F><L><S><G><R><L><I><Y><S><L><L><S><F><I><S><I><P><H><T><I><S><K><I><L><Y><P><V><M><M><F><S><Y><F><A><G><L><S><F><L><S><A><V><S><T><E><R><C><L><S><V><L><W><P><I><W><Y><R><C><H><R><P><T><H><L><S><A><V><V><C><V><L><L><W><A><L><S><L><L><R><S><I><L><E><W><M><L><C><G><F><L><F><S><G><A><D><S><A><W><C><Q><T><S><D><F><I><T><V><A><W><L><I><F><L><C><V><V><L><C><G><S><S><L><V><L><L><I><R><I><L><C><G><S><R><K><I><P><L><T><R><L><Y><V><T><I><L><L><T><V><L><V><F><L><L><C><G><L><P><F><G><I><Q><F><F><L><F><L><W><I><H><V><D><R><E><V><L><F><C><H><V><H><L><V><S><I><F><L><S><A><L><N><S><S><A><N><P><I><I><Y><F><F><V><G><S><F><R><Q><R><Q><N><R><Q><N><L><K><L><V><L><Q><R><A><L><Q><D><A><S><E><V><D><E><G><G><G><Q><L><P><E><E><I><L><E><L><S><G><S><R><L><E><Q>
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.<BOP>
Q96LB2
Q15653
IKBB_HUMAN
Thyroid receptor-interacting protein 9
Homo
<M><A><G><V><A><C><L><G><K><A><A><D><A><D><E><W><C><D><S><G><L><G><S><L><G><P><D><A><A><A><P><G><G><P><G><L><G><A><E><L><G><P><G><L><S><W><A><P><L><V><F><G><Y><V><T><E><D><G><D><T><A><L><H><L><A><V><I><H><Q><H><E><P><F><L><D><F><L><L><G><F><S><A><G><T><E><Y><M><D><L><Q><N><D><L><G><Q><T><A><L><H><L><A><A><I><L><G><E><T><S><T><V><E><K><L><Y><A><A><G><A><G><L><C><V><A><E><R><R><G><H><T><A><L><H><L><A><C><R><V><G><A><H><A><C><A><R><A><L><L><Q><P><R><P><R><R><P><R><E><A><P><D><T><Y><L><A><Q><G><P><D><R><T><P><D><T><N><H><T><P><V><A><L><Y><P><D><S><D><L><E><K><E><E><E><E><S><E><E><D><W><K><L><Q><L><E><A><E><N><Y><E><G><H><T><P><L><H><V><A><V><I><H><K><D><V><E><M><V><R><L><L><R><D><A><G><A><D><L><D><K><P><E><P><T><C><G><R><S><P><L><H><L><A><V><E><A><Q><A><A><D><V><L><E><L><L><L><R><A><G><A><N><P><A><A><R><M><Y><G><G><R><T><P><L><G><S><A><M><L><R><P><N><P><I><L><A><R><L><L><R><A><H><G><A><P><E><P><E><G><E><D><E><K><S><G><P><C><S><S><S><S><D><S><D><S><G><D><E><G><D><E><Y><D><D><I><V><V><H><S><S><R><S><Q><T><R><L><P><P><T><P><A><S><K><P><L><P><D><D><P><R><P><V>
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.<BOP>
Q15653
Q9NPA1
KCMB3_HUMAN
Slo-beta-3
Homo
<M><D><F><S><P><S><S><E><L><G><F><H><F><V><A><F><I><L><L><T><R><H><R><T><A><F><P><A><S><G><K><K><R><E><T><D><Y><S><D><G><D><P><L><D><V><H><K><R><L><P><S><S><A><G><E><D><R><A><V><M><L><G><F><A><M><M><G><F><S><V><L><M><F><F><L><L><G><T><T><I><L><K><P><F><M><L><S><I><Q><R><E><E><S><T><C><T><A><I><H><T><D><I><M><D><D><W><L><D><C><A><F><T><C><G><V><H><C><H><G><Q><G><K><Y><P><C><L><Q><V><F><V><N><L><S><H><P><G><Q><K><A><L><L><H><Y><N><E><E><A><V><Q><I><N><P><K><C><F><Y><T><P><K><C><H><Q><D><R><N><D><L><L><N><S><A><L><D><I><K><E><F><F><D><H><K><N><G><T><P><F><S><C><F><Y><S><P><A><S><Q><S><E><D><V><I><L><I><K><K><Y><D><Q><M><A><I><F><H><C><L><F><W><P><S><L><T><L><L><G><G><A><L><I><V><G><M><V><R><L><T><Q><H><L><S><L><L><C><E><K><Y><S><T><V><V><R><D><E><V><G><G><K><V><P><Y><I><E><Q><H><Q><F><K><L><C><I><M><R><R><S><K><G><R><A><E><K><S>
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.<BOP>
Q9NPA1
A6NEC2
PSAL_HUMAN
Puromycin-sensitive aminopeptidase-like protein
Homo
<M><W><L><A><A><A><A><P><S><L><A><R><R><L><L><F><L><G><P><P><P><P><P><L><L><L><L><V><F><S><R><S><S><R><R><R><L><H><S><L><G><L><A><A><M><P><E><K><R><P><F><E><R><L><P><A><D><V><S><P><I><N><C><S><L><C><L><K><P><D><L><L><D><F><T><F><E><G><K><L><E><A><A><A><Q><V><R><Q><A><T><N><Q><I><V><M><N><C><A><D><I><D><I><I><T><A><S><Y><A><P><E><G><D><E><E><I><H><A><T><G><F><N><Y><Q><N><E><D><E><K><V><T><L><S><F><P><S><T><L><Q><T><G><T><G><T><L><K><I><D><F><V><G><E><L><N><D><K><M><K><G><F><Y><R><S><K><Y><T><T><P><S><G><E><V><R><Y><A><A><V><T><Q><F><E><A><T><D><A><R><R><A><F><P><C><W><D><E><R><A><I><K><A><T><F><D><I><S><L><V><V><P><K><D><R><V><A><L><S><N><M><N><V><I><D><R><K><P><Y><P><D><D><E><N><L><V><E><V><K><F><A><R><T><P><V><T><S><T><Y><L><V><A><F><V><V><G><E><Y><D><F><V><E><T><R><S><K><D><G><V><C><V><C><V><Y><T><P><V><G><K><A><E><Q><G><K><F><A><L><E><V><A><A><K><T><L><P><F><Y><K><D><Y><F><N><V><P><Y><P><L><P><K><I><D><L><I><A><I><A><D><F><A><A><G><A><M><E><N><W><D><L><V><T><Y><R><E><T><A><L><L><I><D><P><K><N><S><C><S><S><S><R><Q><W><V><A><L><V><V><G><H><E><L><A><H><Q><W><F><G><N><L><V><T><M><E><W><W><T><H><L><R><L><N><E><G><F><A><S><W><I><E><Y><L><C><V><D><H><C><F><P><E><Y><D><I><W><T><Q><F><V><S><A><D><Y><T><R><A><Q><E><L><D><A><L><D><N><S><H><P><I><E><V><S><V><G><H><P><S><E><V><D><E><I><F><D><A><I><S><Y><S><K><G><A><S><V><I><R><M><L><H><D><Y><I><G><D><K><D><F><K><K><G><M><N><M><Y><L><T><K><F><Q><Q><K><N><A><A><A><G><N><L>
Aminopeptidase with broad substrate specificity to several peptides.<BOP>
A6NEC2
P52951
GBX2_HUMAN
Gastrulation and brain-specific homeobox protein 2
Homo
<M><S><A><A><F><P><P><S><L><M><M><M><Q><R><P><L><G><S><S><T><A><F><S><I><D><S><L><I><G><S><P><P><Q><P><S><P><G><H><F><V><Y><T><G><Y><P><M><F><M><P><Y><R><P><V><V><L><P><P><P><P><P><P><P><P><A><L><P><Q><A><A><L><Q><P><A><L><P><P><A><H><P><H><H><Q><I><P><S><L><P><T><G><F><C><S><S><L><A><Q><G><M><A><L><T><S><T><L><M><A><T><L><P><G><G><F><S><A><S><P><Q><H><Q><E><A><A><A><A><R><K><F><A><P><Q><P><L><P><G><G><G><N><F><D><K><A><E><A><L><Q><A><D><A><E><D><G><K><G><F><L><A><K><E><G><S><L><L><A><F><S><A><A><E><T><V><Q><A><S><L><V><G><A><V><R><G><Q><G><K><D><E><S><K><V><E><D><D><P><K><G><K><E><E><S><F><S><L><E><S><D><V><D><Y><S><S><D><D><N><L><T><G><Q><A><A><H><K><E><E><D><P><G><H><A><L><E><E><T><P><P><S><S><G><A><A><G><S><T><T><S><T><G><K><N><R><R><R><R><T><A><F><T><S><E><Q><L><L><E><L><E><K><E><F><H><C><K><K><Y><L><S><L><T><E><R><S><Q><I><A><H><A><L><K><L><S><E><V><Q><V><K><I><W><F><Q><N><R><R><A><K><W><K><R><V><K><A><G><N><A><N><S><K><T><G><E><P><S><R><N><P><K><I><V><V><P><I><P><V><H><V><S><R><F><A><I><R><S><Q><H><Q><Q><L><E><Q><A><R><P>
May act as a transcription factor for cell pluripotency and differentiation in the embryo.<BOP>
P52951
Q9BYJ4
TRI34_HUMAN
RING finger protein 21
Homo
<M><A><S><K><I><L><L><N><V><Q><E><E><V><T><C><P><I><C><L><E><L><L><T><E><P><L><S><L><D><C><G><H><S><L><C><R><A><C><I><T><V><S><N><K><E><A><V><T><S><M><G><G><K><S><S><C><P><V><C><G><I><S><Y><S><F><E><H><L><Q><A><N><Q><H><L><A><N><I><V><E><R><L><K><E><V><K><L><S><P><D><N><G><K><K><R><D><L><C><D><H><H><G><E><K><L><L><L><F><C><K><E><D><R><K><V><I><C><W><L><C><E><R><S><Q><E><H><R><G><H><H><T><V><L><T><E><E><V><F><K><E><C><Q><E><K><L><Q><A><V><L><K><R><L><K><K><E><E><E><E><A><E><K><L><E><A><D><I><R><E><E><K><T><S><W><K><Y><Q><V><Q><T><E><R><Q><R><I><Q><T><E><F><D><Q><L><R><S><I><L><N><N><E><E><Q><R><E><L><Q><R><L><E><E><E><E><K><K><T><L><D><K><F><A><E><A><E><D><E><L><V><Q><Q><K><Q><L><V><R><E><L><I><S><D><V><E><C><R><S><Q><W><S><T><M><E><L><L><Q><D><M><S><G><I><M><K><W><S><E><I><W><R><L><K><K><P><K><M><V><S><K><K><L><K><T><V><F><H><A><P><D><L><S><R><M><L><Q><M><F><R><E><L><T><A><V><R><C><Y><W><V><D><V><T><L><N><S><V><N><L><N><L><N><L><V><L><S><E><D><Q><R><Q><V><I><S><V><P><I><W><P><F><Q><C><Y><N><Y><G><V><L><G><S><Q><Y><F><S><S><G><K><H><Y><W><E><V><D><V><S><K><K><T><A><W><I><L><G><V><Y><C><R><T><Y><S><R><H><M><K><Y><V><V><R><R><C><A><N><R><Q><N><L><Y><T><K><Y><R><P><L><F><G><Y><W><V><I><G><L><Q><N><K><C><K><Y><G><V><F><E><E><S><L><S><S><D><P><E><V><L><T><L><S><M><A><V><P><P><C><R><V><G><V><F><L><D><Y><E><A><G><I><V><S><F><F><N><V><T><S><H><G><S><L><I><Y><K><F><S><K><C><C><F><S><Q><P><V><Y><P><Y><F><N><P><W><N><C><P><A><P><M><T><L><C><P><P><S><S>
May function as antiviral protein and may contribute to the defense against retroviral infections.<BOP>
Q9BYJ4
P62888
RL30_HUMAN
Large ribosomal subunit protein eL30
Homo
<M><V><A><A><K><K><T><K><K><S><L><E><S><I><N><S><R><L><Q><L><V><M><K><S><G><K><Y><V><L><G><Y><K><Q><T><L><K><M><I><R><Q><G><K><A><K><L><V><I><L><A><N><N><C><P><A><L><R><K><S><E><I><E><Y><Y><A><M><L><A><K><T><G><V><H><H><Y><S><G><N><N><I><E><L><G><T><A><C><G><K><Y><Y><R><V><C><T><L><A><I><I><D><P><G><D><S><D><I><I><R><S><M><P><E><Q><T><G><E><K>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP>
P62888
O00478
BT3A3_HUMAN
Butyrophilin subfamily 3 member A3
Homo
<M><K><M><A><S><S><L><A><F><L><L><L><N><F><H><V><S><L><F><L><V><Q><L><L><T><P><C><S><A><Q><F><S><V><L><G><P><S><G><P><I><L><A><M><V><G><E><D><A><D><L><P><C><H><L><F><P><T><M><S><A><E><T><M><E><L><R><W><V><S><S><S><L><R><Q><V><V><N><V><Y><A><D><G><K><E><V><E><D><R><Q><S><A><P><Y><R><G><R><T><S><I><L><R><D><G><I><T><A><G><K><A><A><L><R><I><H><N><V><T><A><S><D><S><G><K><Y><L><C><Y><F><Q><D><G><D><F><Y><E><K><A><L><V><E><L><K><V><A><A><L><G><S><D><L><H><I><E><V><K><G><Y><E><D><G><G><I><H><L><E><C><R><S><T><G><W><Y><P><Q><P><Q><I><K><W><S><D><T><K><G><E><N><I><P><A><V><E><A><P><V><V><A><D><G><V><G><L><Y><A><V><A><A><S><V><I><M><R><G><S><S><G><G><G><V><S><C><I><I><R><N><S><L><L><G><L><E><K><T><A><S><I><S><I><A><D><P><F><F><R><S><A><Q><P><W><I><A><A><L><A><G><T><L><P><I><S><L><L><L><L><A><G><A><S><Y><F><L><W><R><Q><Q><K><E><K><I><A><L><S><R><E><T><E><R><E><R><E><M><K><E><M><G><Y><A><A><T><E><Q><E><I><S><L><R><E><K><L><Q><E><E><L><K><W><R><K><I><Q><Y><M><A><R><G><E><K><S><L><A><Y><H><E><W><K><M><A><L><F><K><P><A><D><V><I><L><D><P><D><T><A><N><A><I><L><L><V><S><E><D><Q><R><S><V><Q><R><A><E><E><P><R><D><L><P><D><N><P><E><R><F><E><W><R><Y><C><V><L><G><C><E><N><F><T><S><G><R><H><Y><W><E><V><E><V><G><D><R><K><E><W><H><I><G><V><C><S><K><N><V><E><R><K><K><G><W><V><K><M><T><P><E><N><G><Y><W><T><M><G><L><T><D><G><N><K><Y><R><A><L><T><E><P><R><T><N><L><K><L><P><E><P><P><R><K><V><G><I><F><L><D><Y><E><T><G><E><I><S><F><Y><N><A><T><D><G><S><H><I><Y><T><F><P><H><A><S><F><S><E><P><L><Y><P><V><F><R><I><L><T><L><E><P><T><A><L><T><I><C><P><I><P><K><E><V><E><S><S><P><D><P><D><L><V><P><D><H><S><L><E><T><P><L><T><P><G><L><A><N><E><S><G><E><P><Q><A><E><V><T><S><L><L><L><P><A><H><P><G><A><E><V><S><P><S><A><T><T><N><Q><N><H><K><L><Q><A><R><T><E><A><L><Y>
Plays a role in T-cell responses in the adaptive immune response.<BOP>
O00478
Q6VVB1
NHLC1_HUMAN
RING-type E3 ubiquitin transferase NHLRC1
Homo
<M><A><A><E><A><S><E><S><G><P><A><L><H><E><L><M><R><E><A><E><I><S><L><L><E><C><K><V><C><F><E><K><F><G><H><R><Q><Q><R><R><P><R><N><L><S><C><G><H><V><V><C><L><A><C><V><A><A><L><A><H><P><R><T><L><A><L><E><C><P><F><C><R><R><A><C><R><G><C><D><T><S><D><C><L><P><V><L><H><L><I><E><L><L><G><S><A><L><R><Q><S><P><A><A><H><R><A><A><P><S><A><P><G><A><L><T><C><H><H><T><F><G><G><W><G><T><L><V><N><P><T><G><L><A><L><C><P><K><T><G><R><V><V><V><V><H><D><G><R><R><R><V><K><I><F><D><S><G><G><G><C><A><H><Q><F><G><E><K><G><D><A><A><Q><D><I><R><Y><P><V><D><V><T><I><T><N><D><C><H><V><V><V><T><D><A><G><D><R><S><I><K><V><F><D><F><F><G><Q><I><K><L><V><I><G><G><Q><F><S><L><P><W><G><V><E><T><T><P><Q><N><G><I><V><V><T><D><A><E><A><G><S><L><H><L><L><D><V><D><F><A><E><G><V><L><R><R><T><E><R><L><Q><A><H><L><C><N><P><R><G><V><A><V><S><W><L><T><G><A><I><A><V><L><E><H><P><L><A><L><G><T><G><V><C><S><T><R><V><K><V><F><S><S><S><M><Q><L><V><G><Q><V><D><T><F><G><L><S><L><Y><F><P><S><K><I><T><A><S><A><V><T><F><D><H><Q><G><N><V><I><V><A><D><T><S><G><P><A><I><L><C><L><G><K><P><E><E><F><P><V><P><K><P><M><V><T><H><G><L><S><H><P><V><A><L><T><F><T><K><E><N><S><L><L><V><L><D><T><A><S><H><S><I><K><V><Y><K><V><D><W><G>
E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.<BOP>
Q6VVB1
Q8TAX7
MUC7_HUMAN
Salivary mucin-7
Homo
<M><K><T><L><P><L><F><V><C><I><C><A><L><S><A><C><F><S><F><S><E><G><R><E><R><D><H><E><L><R><H><R><R><H><H><H><Q><S><P><K><S><H><F><E><L><P><H><Y><P><G><L><L><A><H><Q><K><P><F><I><R><K><S><Y><K><C><L><H><K><R><C><R><P><K><L><P><P><S><P><N><N><P><P><K><F><P><N><P><H><Q><P><P><K><H><P><D><K><N><S><S><V><V><N><P><T><L><V><A><T><T><Q><I><P><S><V><T><F><P><S><A><S><T><K><I><T><T><L><P><N><V><T><F><L><P><Q><N><A><T><T><I><S><S><R><E><N><V><N><T><S><S><S><V><A><T><L><A><P><V><N><S><P><A><P><Q><D><T><T><A><A><P><P><T><P><S><A><T><T><P><A><P><P><S><S><S><A><P><P><E><T><T><A><A><P><P><T><P><S><A><T><T><Q><A><P><P><S><S><S><A><P><P><E><T><T><A><A><P><P><T><P><P><A><T><T><P><A><P><P><S><S><S><A><P><P><E><T><T><A><A><P><P><T><P><S><A><T><T><P><A><P><L><S><S><S><A><P><P><E><T><T><A><V><P><P><T><P><S><A><T><T><L><D><P><S><S><A><S><A><P><P><E><T><T><A><A><P><P><T><P><S><A><T><T><P><A><P><P><S><S><P><A><P><Q><E><T><T><A><A><P><I><T><T><P><N><S><S><P><T><T><L><A><P><D><T><S><E><T><S><A><A><P><T><H><Q><T><T><T><S><V><T><T><Q><T><T><T><T><K><Q><P><T><S><A><P><G><Q><N><K><I><S><R><F><L><L><Y><M><K><N><L><L><N><R><I><I><D><D><M><V><E><Q>
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.<BOP>
Q8TAX7
Q96DR8
MUCL1_HUMAN
Small breast epithelial mucin
Homo
<M><K><F><L><A><V><L><V><L><L><G><V><S><I><F><L><V><S><A><Q><N><P><T><T><A><A><P><A><D><T><Y><P><A><T><G><P><A><D><D><E><A><P><D><A><E><T><T><A><A><A><T><T><A><T><T><A><A><P><T><T><A><T><T><A><A><S><T><T><A><R><K><D><I><P><V><L><P><K><W><V><G><D><L><P><N><G><R><V><C><P>
May play a role as marker for the diagnosis of metastatic breast cancer.<BOP>
Q96DR8
Q495W5
FUT11_HUMAN
Galactoside 3-L-fucosyltransferase 11
Homo
<M><A><A><G><P><I><R><V><V><L><V><L><L><G><V><L><S><V><C><A><A><S><G><H><G><S><V><A><E><R><E><A><G><G><E><A><E><W><A><E><P><W><D><G><A><V><F><R><P><P><S><A><L><G><A><V><G><V><T><R><S><S><G><T><P><R><P><G><R><E><E><A><G><D><L><P><V><L><L><W><W><S><P><G><L><F><P><H><F><P><G><D><S><E><R><I><E><C><A><R><G><A><C><V><A><S><R><N><R><R><A><L><R><D><S><R><T><R><A><L><L><F><Y><G><T><D><F><R><A><S><A><A><P><L><P><R><L><A><H><Q><S><W><A><L><L><H><E><E><S><P><L><N><N><F><L><L><S><H><G><P><G><I><R><L><F><N><L><T><S><T><F><S><R><H><S><D><Y><P><L><S><L><Q><W><L><P><G><T><A><Y><L><R><R><P><V><P><P><P><M><E><R><A><E><W><R><R><R><G><Y><A><P><L><L><Y><L><Q><S><H><C><D><V><P><A><D><R><D><R><Y><V><R><E><L><M><R><H><I><P><V><D><S><Y><G><K><C><L><Q><N><R><E><L><P><T><A><R><L><Q><D><T><A><T><A><T><T><E><D><P><E><L><L><A><F><L><S><R><Y><K><F><H><L><A><L><E><N><A><I><C><N><D><Y><M><T><E><K><L><W><R><P><M><H><L><G><A><V><P><V><Y><R><G><S><P><S><V><R><D><W><M><P><N><N><H><S><V><I><L><I><D><D><F><E><S><P><Q><K><L><A><E><F><I><D><F><L><D><K><N><D><E><E><Y><M><K><Y><L><A><Y><K><Q><P><G><G><I><T><N><Q><F><L><L><D><S><L><K><H><R><E><W><G><V><N><D><P><L><L><P><N><Y><L><N><G><F><E><C><F><V><C><D><Y><E><L><A><R><L><D><A><E><K><A><H><A><A><S><P><G><D><S><P><V><F><E><P><H><I><A><Q><P><S><H><M><D><C><P><V><P><T><P><G><F><G><N><V><E><E><I><P><E><N><D><S><W><K><E><M><W><L><Q><D><Y><W><Q><G><L><D><Q><G><E><A><L><T><A><M><I><H><N><N><E><T><E><Q><T><K><F><W><D><Y><L><H><E><I><F><M><K><R><Q><H><L>
Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit.<BOP>
Q495W5
Q96RQ3
MCCA_HUMAN
3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha
Homo
<M><A><A><A><S><A><V><S><V><L><L><V><A><A><E><R><N><R><W><H><R><L><P><S><L><L><L><P><P><R><T><W><V><W><R><Q><R><T><M><K><Y><T><T><A><T><G><R><N><I><T><K><V><L><I><A><N><R><G><E><I><A><C><R><V><M><R><T><A><K><K><L><G><V><Q><T><V><A><V><Y><S><E><A><D><R><N><S><M><H><V><D><M><A><D><E><A><Y><S><I><G><P><A><P><S><Q><Q><S><Y><L><S><M><E><K><I><I><Q><V><A><K><T><S><A><A><Q><A><I><H><P><G><C><G><F><L><S><E><N><M><E><F><A><E><L><C><K><Q><E><G><I><I><F><I><G><P><P><P><S><A><I><R><D><M><G><I><K><S><T><S><K><S><I><M><A><A><A><G><V><P><V><V><E><G><Y><H><G><E><D><Q><S><D><Q><C><L><K><E><H><A><R><R><I><G><Y><P><V><M><I><K><A><V><R><G><G><G><G><K><G><M><R><I><V><R><S><E><Q><E><F><Q><E><Q><L><E><S><A><R><R><E><A><K><K><S><F><N><D><D><A><M><L><I><E><K><F><V><D><T><P><R><H><V><E><V><Q><V><F><G><D><H><H><G><N><A><V><Y><L><F><E><R><D><C><S><V><Q><R><R><H><Q><K><I><I><E><E><A><P><A><P><G><I><K><S><E><V><R><K><K><L><G><E><A><A><V><R><A><A><K><A><V><N><Y><V><G><A><G><T><V><E><F><I><M><D><S><K><H><N><F><C><F><M><E><M><N><T><R><L><Q><V><E><H><P><V><T><E><M><I><T><G><T><D><L><V><E><W><Q><L><R><I><A><A><G><E><K><I><P><L><S><Q><E><E><I><T><L><Q><G><H><A><F><E><A><R><I><Y><A><E><D><P><S><N><N><F><M><P><V><A><G><P><L><V><H><L><S><T><P><R><A><D><P><S><T><R><I><E><T><G><V><R><Q><G><D><E><V><S><V><H><Y><D><P><M><I><A><K><L><V><V><W><A><A><D><R><Q><A><A><L><T><K><L><R><Y><S><L><R><Q><Y><N><I><V><G><L><H><T><N><I><D><F><L><L><N><L><S><G><H><P><E><F><E><A><G><N><V><H><T><D><F><I><P><Q><H><H><K><Q><L><L><L><S><R><K><A><A><A><K><E><S><L><C><Q><A><A><L><G><L><I><L><K><E><K><A><M><T><D><T><F><T><L><Q><A><H><D><Q><F><S><P><F><S><S><S><S><G><R><R><L><N><I><S><Y><T><R><N><M><T><L><K><D><G><K><N><N><V><A><I><A><V><T><Y><N><H><D><G><S><Y><S><M><Q><I><E><D><K><T><F><Q><V><L><G><N><L><Y><S><E><G><D><C><T><Y><L><K><C><S><V><N><G><V><A><S><K><A><K><L><I><I><L><E><N><T><I><Y><L><F><S><K><E><G><S><I><E><I><D><I><P><V><P><K><Y><L><S><S><V><S><S><Q><E><T><Q><G><G><P><L><A><P><M><T><G><T><I><E><K><V><F><V><K><A><G><D><K><V><K><A><G><D><S><L><M><V><M><I><A><M><K><M><E><H><T><I><K><S><P><K><D><G><T><V><K><K><V><F><Y><R><E><G><A><Q><A><N><R><H><T><P><L><V><E><F><E><E><E><E><S><D><K><R><E><S><E>
Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.<BOP>
Q96RQ3
Q96BD5
PF21A_HUMAN
BRAF35-HDAC complex protein BHC80
Homo
<M><E><L><Q><T><L><Q><E><A><L><K><V><E><I><Q><V><H><Q><K><L><V><A><Q><M><K><Q><D><P><Q><N><A><D><L><K><K><Q><L><H><E><L><Q><A><K><I><T><A><L><S><E><K><Q><K><R><V><V><E><Q><L><R><K><N><L><I><V><K><Q><E><Q><P><D><K><F><Q><I><Q><P><L><P><Q><S><E><N><K><L><Q><T><A><Q><Q><Q><P><L><Q><Q><L><Q><Q><Q><Q><Q><Y><H><H><H><H><A><Q><Q><S><A><A><A><S><P><N><L><T><A><S><Q><K><T><V><T><T><A><S><M><I><T><T><K><T><L><P><L><V><L><K><A><A><T><A><T><M><P><A><S><V><V><G><Q><R><P><T><I><A><M><V><T><A><I><N><S><Q><K><A><V><L><S><T><D><V><Q><N><T><P><V><N><L><Q><T><S><S><K><V><T><G><P><G><A><E><A><V><Q><I><V><A><K><N><T><V><T><L><V><Q><A><T><P><P><Q><P><I><K><V><P><Q><F><I><P><P><P><R><L><T><P><R><P><N><F><L><P><Q><V><R><P><K><P><V><A><Q><N><N><I><P><I><A><P><A><P><P><P><M><L><A><A><P><Q><L><I><Q><R><P><V><M><L><T><K><F><T><P><T><T><L><P><T><S><Q><N><S><I><H><P><V><R><V><V><N><G><Q><T><A><T><I><A><K><T><F><P><M><A><Q><L><T><S><I><V><I><A><T><P><G><T><R><L><A><G><P><Q><T><V><Q><L><S><K><P><S><L><E><K><Q><T><V><K><S><H><T><E><T><D><E><K><Q><T><E><S><R><T><I><T><P><P><A><A><P><K><P><K><R><E><E><N><P><Q><K><L><A><F><M><V><S><L><G><L><V><T><H><D><H><L><E><E><I><Q><S><K><R><Q><E><R><K><R><R><T><T><A><N><P><V><Y><S><G><A><V><F><E><P><E><R><K><K><S><A><V><T><Y><L><N><S><T><M><H><P><G><T><R><K><R><G><R><P><P><K><Y><N><A><V><L><G><F><G><A><L><T><P><T><S><P><Q><S><S><H><P><D><S><P><E><N><E><K><T><E><T><T><F><T><F><P><A><P><V><Q><P><V><S><L><P><S><P><T><S><T><D><G><D><I><H><E><D><F><C><S><V><C><R><K><S><G><Q><L><L><M><C><D><T><C><S><R><V><Y><H><L><D><C><L><D><P><P><L><K><T><I><P><K><G><M><W><I><C><P><R><C><Q><D><Q><M><L><K><K><E><E><A><I><P><W><P><G><T><L><A><I><V><H><S><Y><I><A><Y><K><A><A><K><E><E><E><K><Q><K><L><L><K><W><S><S><D><L><K><Q><E><R><E><Q><L><E><Q><K><V><K><Q><L><S><N><S><I><S><K><C><M><E><M><K><N><T><I><L><A><R><Q><K><E><M><H><S><S><L><E><K><V><K><Q><L><I><R><L><I><H><G><I><D><L><S><K><P><V><D><S><E><A><T><V><G><A><I><S><N><G><P><D><C><T><P><P><A><N><A><A><T><S><T><P><A><P><S><P><S><S><Q><S><C><T><A><N><C><N><Q><G><E><E><T><K>
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.<BOP>
Q96BD5
P06312
KV401_HUMAN
Ig kappa chain V-IV region STH
Homo
<M><V><L><Q><T><Q><V><F><I><S><L><L><L><W><I><S><G><A><Y><G><D><I><V><M><T><Q><S><P><D><S><L><A><V><S><L><G><E><R><A><T><I><N><C><K><S><S><Q><S><V><L><Y><S><S><N><N><K><N><Y><L><A><W><Y><Q><Q><K><P><G><Q><P><P><K><L><L><I><Y><W><A><S><T><R><E><S><G><V><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><A><E><D><V><A><V><Y><Y><C><Q><Q><Y><Y><S><T><P>
V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P06312
P26641
EF1G_HUMAN
eEF-1B gamma
Homo
<M><A><A><G><T><L><Y><T><Y><P><E><N><W><R><A><F><K><A><L><I><A><A><Q><Y><S><G><A><Q><V><R><V><L><S><A><P><P><H><F><H><F><G><Q><T><N><R><T><P><E><F><L><R><K><F><P><A><G><K><V><P><A><F><E><G><D><D><G><F><C><V><F><E><S><N><A><I><A><Y><Y><V><S><N><E><E><L><R><G><S><T><P><E><A><A><A><Q><V><V><Q><W><V><S><F><A><D><S><D><I><V><P><P><A><S><T><W><V><F><P><T><L><G><I><M><H><H><N><K><Q><A><T><E><N><A><K><E><E><V><R><R><I><L><G><L><L><D><A><Y><L><K><T><R><T><F><L><V><G><E><R><V><T><L><A><D><I><T><V><V><C><T><L><L><W><L><Y><K><Q><V><L><E><P><S><F><R><Q><A><F><P><N><T><N><R><W><F><L><T><C><I><N><Q><P><Q><F><R><A><V><L><G><E><V><K><L><C><E><K><M><A><Q><F><D><A><K><K><F><A><E><T><Q><P><K><K><D><T><P><R><K><E><K><G><S><R><E><E><K><Q><K><P><Q><A><E><R><K><E><E><K><K><A><A><A><P><A><P><E><E><E><M><D><E><C><E><Q><A><L><A><A><E><P><K><A><K><D><P><F><A><H><L><P><K><S><T><F><V><L><D><E><F><K><R><K><Y><S><N><E><D><T><L><S><V><A><L><P><Y><F><W><E><H><F><D><K><D><G><W><S><L><W><Y><S><E><Y><R><F><P><E><E><L><T><Q><T><F><M><S><C><N><L><I><T><G><M><F><Q><R><L><D><K><L><R><K><N><A><F><A><S><V><I><L><F><G><T><N><N><S><S><S><I><S><G><V><W><V><F><R><G><Q><E><L><A><F><P><L><S><P><D><W><Q><V><D><Y><E><S><Y><T><W><R><K><L><D><P><G><S><E><E><T><Q><T><L><V><R><E><Y><F><S><W><E><G><A><F><Q><H><V><G><K><A><F><N><Q><G><K><I><F><K>
Probably plays a role in anchoring the complex to other cellular components.<BOP>
P26641
Q96R27
OR2M4_HUMAN
Olfactory receptor TPCR100
Homo
<M><V><W><E><N><Q><T><F><N><S><I><F><I><L><L><G><I><F><N><H><S><P><T><H><T><F><L><F><S><L><V><L><G><I><F><S><L><A><L><M><E><N><I><S><M><V><L><L><I><Y><I><E><K><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><L><M><L><I><C><T><T><L><P><K><M><I><F><S><Y><L><S><G><K><K><S><I><S><L><A><G><C><G><T><Q><I><F><F><Y><V><S><L><L><G><A><E><C><F><L><L><A><V><M><A><Y><D><R><Y><V><A><I><C><H><P><L><Q><Y><T><I><L><M><N><P><K><L><C><V><F><M><T><V><A><S><W><T><L><G><S><L><D><G><I><I><V><L><A><A><V><L><S><F><S><Y><C><S><S><L><E><I><H><H><F><F><C><D><V><A><A><L><L><P><L><S><C><T><E><T><S><A><F><E><R><L><L><V><I><C><C><V><V><M><L><I><F><P><V><S><V><I><I><L><S><Y><S><H><V><L><R><A><V><I><H><M><G><S><G><E><S><R><R><K><A><F><T><T><C><S><S><H><L><S><V><V><G><L><Y><Y><G><A><A><M><F><M><Y><M><R><P><A><S><K><H><T><P><D><Q><D><K><M><V><S><A><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><F><R><A><L><Q><K><V><L><K><K><R><K><L><I>
Odorant receptor.<BOP>
Q96R27
P55735
SEC13_HUMAN
SEC13-related protein
Homo
<M><V><S><V><I><N><T><V><D><T><S><H><E><D><M><I><H><D><A><Q><M><D><Y><Y><G><T><R><L><A><T><C><S><S><D><R><S><V><K><I><F><D><V><R><N><G><G><Q><I><L><I><A><D><L><R><G><H><E><G><P><V><W><Q><V><A><W><A><H><P><M><Y><G><N><I><L><A><S><C><S><Y><D><R><K><V><I><I><W><R><E><E><N><G><T><W><E><K><S><H><E><H><A><G><H><D><S><S><V><N><S><V><C><W><A><P><H><D><Y><G><L><I><L><A><C><G><S><S><D><G><A><I><S><L><L><T><Y><T><G><E><G><Q><W><E><V><K><K><I><N><N><A><H><T><I><G><C><N><A><V><S><W><A><P><A><V><V><P><G><S><L><I><D><H><P><S><G><Q><K><P><N><Y><I><K><R><F><A><S><G><G><C><D><N><L><I><K><L><W><K><E><E><E><D><G><Q><W><K><E><E><Q><K><L><E><A><H><S><D><W><V><R><D><V><A><W><A><P><S><I><G><L><P><T><S><T><I><A><S><C><S><Q><D><G><R><V><F><I><W><T><C><D><D><A><S><S><N><T><W><S><P><K><L><L><H><K><F><N><D><V><V><W><H><V><S><W><S><I><T><A><N><I><L><A><V><S><G><G><D><N><K><V><T><L><W><K><E><S><V><D><G><Q><W><V><C><I><S><D><V><N><K><G><Q><G><S><V><S><A><S><V><T><E><G><Q><Q><N><E><Q>
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 .<BOP>
P55735
Q9NZ01
TECR_HUMAN
Trans-2,3-enoyl-CoA reductase
Homo
<M><K><H><Y><E><V><E><I><L><D><A><K><T><R><E><K><L><C><F><L><D><K><V><E><P><H><A><T><I><A><E><I><K><N><L><F><T><K><T><H><P><Q><W><Y><P><A><R><Q><S><L><R><L><D><P><K><G><K><S><L><K><D><E><D><V><L><Q><K><L><P><V><G><T><T><A><T><L><Y><F><R><D><L><G><A><Q><I><S><W><V><T><V><F><L><T><E><Y><A><G><P><L><F><I><Y><L><L><F><Y><F><R><V><P><F><I><Y><G><H><K><Y><D><F><T><S><S><R><H><T><V><V><H><L><A><C><I><C><H><S><F><H><Y><I><K><R><L><L><E><T><L><F><V><H><R><F><S><H><G><T><M><P><L><R><N><I><F><K><N><C><T><Y><Y><W><G><F><A><A><W><M><A><Y><Y><I><N><H><P><L><Y><T><P><P><T><Y><G><A><Q><Q><V><K><L><A><L><A><I><F><V><I><C><Q><L><G><N><F><S><I><H><M><A><L><R><D><L><R><P><A><G><S><K><T><R><K><I><P><Y><P><T><K><N><P><F><T><W><L><F><L><L><V><S><C><P><N><Y><T><Y><E><V><G><S><W><I><G><F><A><I><M><T><Q><C><L><P><V><A><L><F><S><L><V><G><F><T><Q><M><T><I><W><A><K><G><K><H><R><S><Y><L><K><E><F><R><D><Y><P><P><L><R><M><P><I><I><P><F><L><L>
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway . Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle . This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle . This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation . Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators . Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA .<BOP>
Q9NZ01
Q8WWC4
MAIP1_HUMAN
Matrix AAA peptidase-interacting protein 1
Homo
<M><A><L><A><A><R><L><L><P><Q><F><L><H><S><R><S><L><P><C><G><A><V><R><L><R><T><P><A><V><A><E><V><R><L><P><S><A><T><L><C><Y><F><C><R><C><R><L><G><L><G><A><A><L><F><P><R><S><A><R><A><L><A><A><S><A><L><P><A><Q><G><S><R><W><P><V><L><S><S><P><G><L><P><A><A><F><A><S><F><P><A><C><P><Q><R><S><Y><S><T><E><E><K><P><Q><Q><H><Q><K><T><K><M><I><V><L><G><F><S><N><P><I><N><W><V><R><T><R><I><K><A><F><L><I><W><A><Y><F><D><K><E><F><S><I><T><E><F><S><E><G><A><K><Q><A><F><A><H><V><S><K><L><L><S><Q><C><K><F><D><L><L><E><E><L><V><A><K><E><V><L><H><A><L><K><E><K><V><T><S><L><P><D><N><H><K><N><A><L><A><A><N><I><D><E><I><V><F><T><S><T><G><D><I><S><I><Y><Y><D><E><K><G><R><K><F><V><N><I><L><M><C><F><W><Y><L><T><S><A><N><I><P><S><E><T><L><R><G><A><S><V><F><Q><V><K><L><G><N><Q><N><V><E><T><K><Q><L><L><S><A><S><Y><E><F><Q><R><E><F><T><Q><G><V><K><P><D><W><T><I><A><R><I><E><H><S><K><L><L><E>
Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation . Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) .<BOP>
Q8WWC4
A0A0B4J264
TV381_HUMAN
T cell receptor alpha variable 38-1
Homo
<M><T><R><V><S><L><L><W><A><V><V><V><S><T><C><L><E><S><G><M><A><Q><T><V><T><Q><S><Q><P><E><M><S><V><Q><E><A><E><T><V><T><L><S><C><T><Y><D><T><S><E><N><N><Y><Y><L><F><W><Y><K><Q><P><P><S><R><Q><M><I><L><V><I><R><Q><E><A><Y><K><Q><Q><N><A><T><E><N><R><F><S><V><N><F><Q><K><A><A><K><S><F><S><L><K><I><S><D><S><Q><L><G><D><T><A><M><Y><F><C><A><F><M><K>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J264
Q9BUN8
DERL1_HUMAN
Der1-like protein 1
Homo
<M><S><D><I><G><D><W><F><R><S><I><P><A><I><T><R><Y><W><F><A><A><T><V><A><V><P><L><V><G><K><L><G><L><I><S><P><A><Y><L><F><L><W><P><E><A><F><L><Y><R><F><Q><I><W><R><P><I><T><A><T><F><Y><F><P><V><G><P><G><T><G><F><L><Y><L><V><N><L><Y><F><L><Y><Q><Y><S><T><R><L><E><T><G><A><F><D><G><R><P><A><D><Y><L><F><M><L><L><F><N><W><I><C><I><V><I><T><G><L><A><M><D><M><Q><L><L><M><I><P><L><I><M><S><V><L><Y><V><W><A><Q><L><N><R><D><M><I><V><S><F><W><F><G><T><R><F><K><A><C><Y><L><P><W><V><I><L><G><F><N><Y><I><I><G><G><S><V><I><N><E><L><I><G><N><L><V><G><H><L><Y><F><F><L><M><F><R><Y><P><M><D><L><G><G><R><N><F><L><S><T><P><Q><F><L><Y><R><W><L><P><S><R><R><G><G><V><S><G><F><G><V><P><P><A><S><M><R><R><A><A><D><Q><N><G><G><G><G><R><H><N><W><G><Q><G><F><R><L><G><D><Q>
(Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.<BOP>
Q9BUN8
Q9NX36
DJC28_HUMAN
DnaJ homolog subfamily C member 28
Homo
<M><N><T><M><Y><V><M><M><A><Q><I><L><R><S><H><L><I><K><A><T><V><I><P><N><R><V><K><M><L><P><Y><F><G><I><I><R><N><R><M><M><S><T><H><K><S><K><K><K><I><R><E><Y><Y><R><L><L><N><V><E><E><G><C><S><A><D><E><V><R><E><S><F><H><K><L><A><K><Q><Y><H><P><D><S><G><S><N><T><A><D><S><A><T><F><I><R><I><E><K><A><Y><R><K><V><L><S><H><V><I><E><Q><T><N><A><S><Q><S><K><G><E><E><E><E><D><V><E><K><F><K><Y><K><T><P><Q><H><R><H><Y><L><S><F><E><G><I><G><F><G><T><P><T><Q><R><E><K><H><Y><R><Q><F><R><A><D><R><A><A><E><Q><V><M><E><Y><Q><K><Q><K><L><Q><S><Q><Y><F><P><D><S><V><I><V><K><N><I><R><Q><S><K><Q><Q><K><I><T><Q><A><I><E><R><L><V><E><D><L><I><Q><E><S><M><A><K><G><D><F><D><N><L><S><G><K><G><K><P><L><K><K><F><S><D><C><S><Y><I><D><P><M><T><H><N><L><N><R><I><L><I><D><N><G><Y><Q><P><E><W><I><L><K><Q><K><E><I><S><D><T><I><E><Q><L><R><E><A><I><L><V><S><R><K><K><L><G><N><P><M><T><P><T><E><K><K><Q><W><N><H><V><C><E><Q><F><Q><E><N><I><R><K><L><N><K><R><I><N><D><F><N><L><I><V><P><I><L><T><R><Q><K><V><H><F><D><A><Q><K><E><I><V><R><A><Q><K><I><Y><E><T><L><I><K><T><K><E><V><T><D><R><N><P><N><N><L><D><Q><G><E><G><E><K><T><P><E><I><K><K><G><F><L><N><W><M><N><L><W><K><F><I><K><I><R><S><F>
May have a role in protein folding or as a chaperone.<BOP>
Q9NX36
Q5NDL2
EOGT_HUMAN
Extracellular O-linked N-acetylglucosamine transferase
Homo
<M><L><M><L><F><V><F><G><V><L><L><H><E><V><S><L><S><G><Q><N><E><A><P><P><N><T><H><S><I><P><G><E><P><L><Y><N><Y><A><S><I><R><L><P><E><E><H><I><P><F><F><L><H><N><N><R><H><I><A><T><V><C><R><K><D><S><L><C><P><Y><K><K><H><L><E><K><L><K><Y><C><W><G><Y><E><K><S><C><K><P><E><F><R><F><G><Y><P><V><C><S><Y><V><D><M><G><W><T><D><T><L><E><S><A><E><D><I><F><W><K><Q><A><D><F><G><Y><A><R><E><R><L><E><E><M><H><V><L><C><Q><P><K><E><T><S><D><S><S><L><V><C><S><R><Y><L><Q><Y><C><R><A><T><N><L><Y><L><D><L><R><N><I><K><R><N><H><D><R><F><K><E><D><F><F><Q><S><G><E><I><G><G><H><C><K><L><D><I><R><T><L><T><S><E><G><Q><R><K><S><P><L><Q><S><W><F><A><E><L><Q><S><Y><T><Q><L><N><F><R><P><I><E><D><A><K><C><D><I><V><I><E><K><P><T><Y><F><M><K><L><D><A><G><V><N><M><Y><H><H><F><C><D><F><I><N><L><Y><I><T><Q><H><V><N><N><S><F><S><T><D><V><Y><I><V><M><W><D><T><S><S><Y><G><Y><G><D><L><F><S><D><T><W><N><A><F><T><D><Y><D><V><I><H><L><K><T><Y><D><S><K><R><V><C><F><K><E><A><V><F><S><L><L><P><R><M><R><Y><G><L><F><Y><N><T><P><L><I><S><G><C><Q><N><T><G><L><F><R><A><F><A><Q><H><V><L><H><R><L><N><I><T><Q><E><G><P><K><D><G><K><I><R><V><T><I><L><A><R><S><T><E><Y><R><K><I><L><N><Q><N><E><L><V><N><A><L><K><T><V><S><T><F><E><V><Q><I><V><D><Y><K><Y><R><E><L><G><F><L><D><Q><L><R><I><T><H><N><T><D><I><F><I><G><M><H><G><A><G><L><T><H><L><L><F><L><P><D><W><A><A><V><F><E><L><Y><N><C><E><D><E><R><C><Y><L><D><L><A><R><L><R><G><V><H><Y><I><T><W><R><R><Q><N><K><V><F><P><Q><D><K><G><H><H><P><T><L><G><E><H><P><K><F><T><N><Y><S><F><D><V><E><E><F><M><Y><L><V><L><Q><A><A><D><H><V><L><Q><H><P><K><W><P><F><K><K><K><H><D><E><L>
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.<BOP>
Q5NDL2
Q9P0V8
SLAF8_HUMAN
BCM-like membrane protein
Homo
<M><V><M><R><P><L><W><S><L><L><L><W><E><A><L><L><P><I><T><V><T><G><A><Q><V><L><S><K><V><G><G><S><V><L><L><V><A><A><R><P><P><G><F><Q><V><R><E><A><I><W><R><S><L><W><P><S><E><E><L><L><A><T><F><F><R><G><S><L><E><T><L><Y><H><S><R><F><L><G><R><A><Q><L><H><S><N><L><S><L><E><L><G><P><L><E><S><G><D><S><G><N><F><S><V><L><M><V><D><T><R><G><Q><P><W><T><Q><T><L><Q><L><K><V><Y><D><A><V><P><R><P><V><V><Q><V><F><I><A><V><E><R><D><A><Q><P><S><K><T><C><Q><V><F><L><S><C><W><A><P><N><I><S><E><I><T><Y><S><W><R><R><E><T><T><M><D><F><G><M><E><P><H><S><L><F><T><D><G><Q><V><L><S><I><S><L><G><P><G><D><R><D><V><A><Y><S><C><I><V><S><N><P><V><S><W><D><L><A><T><V><T><P><W><D><S><C><H><H><E><A><A><P><G><K><A><S><Y><K><D><V><L><L><V><V><V><P><V><S><L><L><L><M><L><V><T><L><F><S><A><W><H><W><C><P><C><S><G><K><K><K><K><D><V><H><A><D><R><V><G><P><E><T><E><N><P><L><V><Q><D><L><P>
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.<BOP>
Q9P0V8
P0DMP2
SRG2B_HUMAN
SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2
Homo
<M><T><S><P><A><K><F><K><K><D><K><E><I><I><A><E><Y><D><T><Q><V><K><E><I><R><A><Q><L><T><E><Q><M><K><C><L><D><Q><Q><C><E><L><R><V><Q><L><L><Q><D><L><Q><D><F><F><R><K><K><A><E><I><E><M><D><Y><S><R><N><L><E><K><L><A><E><R><F><L><A><K><T><C><S><T><K><D><Q><Q><F><K><K><D><Q><N><V><L><S><P><V><N><C><W><N><L><L><L><N><Q><V><K><R><E><S><R><D><H><T><T><L><S><D><I><Y><L><N><N><I><I><P><R><F><V><Q><V><S><E><D><S><G><R><L><F><K><K><S><K><E><V><G><Q><Q><L><Q><D><D><L><M><K><V><L><N><E><L><Y><S><V><M><K><T><Y><H><M><Y><N><A><D><S><I><S><A><Q><S><K><L><K><E><A><E><K><Q><E><E><K><Q><I><G><K><S><V><K><Q><E><D><R><Q><T><P><R><S><P><D><S><T><A><N><V><R><I><E><E><K><H><V><R><R><S><S><V><K><K><I><E><K><M><K><E><K><R><Q><A><K><Y><T><E><N><K><L><K><A><I><K><A><R><N><E><Y><L><L><A><L><E><A><T><N><A><S><V><F><K><Y><Y><I><H><D><L><S><D><L><I><D><C><C><D><L><G><Y><H><A><S><L><N><R><A><L><R><T><F><L><S><A><E><L><N><L><E><Q><S><K><H><E><G><L><D><A><I><E><N><A><V><E><N><L><D><A><T><S><D><K><Q><R><L><M><E><M><Y><N><N><V><F><C><P><P><M><K><F><E><F><Q><P><H><M><G><D><M><A><S><Q><L><C><A><Q><Q><P><V><Q><S><E><L><L><Q><R><C><Q><Q><L><Q><S><R><L><S><T><L><K><I><E><N><E><E><V><K><K><T><M><E><A><T><L><Q><T><I><Q><D><I><V><T><V><E><D><F><D><V><S><D><C><F><Q><Y><S><N><S><M><E><S><V><K><S><T><V><S><E><T><F><M><S><K><P><S><I><A><K><R><R><A><N><Q><Q><E><T><E><Q><F><Y><F><T><V><R><E><C><Y><G><F>
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 . In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood .<BOP>
P0DMP2
Q6NS38
ALKB2_HUMAN
Oxy DC1
Homo
<M><D><R><F><L><V><K><G><A><Q><G><G><L><L><R><K><Q><E><E><Q><E><P><T><G><E><E><P><A><V><L><G><G><D><K><E><S><T><R><K><R><P><R><R><E><A><P><G><N><G><G><H><S><A><G><P><S><W><R><H><I><R><A><E><G><L><D><C><S><Y><T><V><L><F><G><K><A><E><A><D><E><I><F><Q><E><L><E><K><E><V><E><Y><F><T><G><A><L><A><R><V><Q><V><F><G><K><W><H><S><V><P><R><K><Q><A><T><Y><G><D><A><G><L><T><Y><T><F><S><G><L><T><L><S><P><K><P><W><I><P><V><L><E><R><I><R><D><H><V><S><G><V><T><G><Q><T><F><N><F><V><L><I><N><R><Y><K><D><G><C><D><H><I><G><E><H><R><D><D><E><R><E><L><A><P><G><S><P><I><A><S><V><S><F><G><A><C><R><D><F><V><F><R><H><K><D><S><R><G><K><S><P><S><R><R><V><A><V><V><R><L><P><L><A><H><G><S><L><L><M><M><N><H><P><T><N><T><H><W><Y><H><S><L><P><V><R><K><K><V><L><A><P><R><V><N><L><T><F><R><K><I><L><L><T><K><K>
Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA . Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis . Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine . Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription . In
Q6NS38
Q7RTS7
K2C74_HUMAN
Type-II keratin Kb37
Homo
<M><S><R><Q><L><N><I><K><S><S><G><D><K><G><N><F><S><V><H><S><A><V><V><P><R><K><A><V><G><S><L><A><S><Y><C><A><A><G><R><G><A><G><A><G><F><G><S><R><S><L><Y><S><L><G><G><N><R><R><I><S><F><N><V><A><G><G><G><V><R><A><G><G><Y><G><F><R><P><G><S><G><Y><G><G><G><R><A><S><G><F><A><G><S><M><F><G><S><V><A><L><G><P><A><C><L><S><V><C><P><P><G><G><I><H><Q><V><T><V><N><K><S><L><L><A><P><L><N><V><E><L><D><P><E><I><Q><K><V><R><A><Q><E><R><E><Q><I><K><V><L><N><D><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><Q><V><L><E><T><K><W><E><L><L><Q><Q><L><D><L><N><N><C><K><K><N><L><E><P><I><L><E><G><Y><I><S><N><L><R><K><Q><L><E><T><L><S><G><D><R><V><R><L><D><S><E><L><R><S><M><R><D><L><V><E><D><Y><K><K><R><Y><E><V><E><I><N><R><R><T><T><A><E><N><E><F><V><V><L><K><K><D><A><D><A><A><Y><A><V><K><V><E><L><Q><A><K><V><D><S><L><D><K><E><I><K><F><L><K><C><L><Y><D><A><E><I><A><Q><I><Q><T><H><A><S><E><T><S><V><I><L><S><M><D><N><N><R><D><L><D><L><D><S><I><I><A><E><V><R><M><H><Y><E><E><I><A><L><K><S><K><A><E><A><E><A><L><Y><Q><T><K><I><Q><E><L><Q><L><A><A><S><R><H><G><D><D><L><K><H><T><R><S><E><M><V><E><L><N><R><L><I><Q><R><I><R><C><E><I><G><N><V><K><K><Q><R><A><S><L><E><T><A><I><A><D><A><E><Q><R><G><D><N><A><L><K><D><A><Q><A><K><L><D><E><L><E><G><A><L><H><Q><A><K><E><E><L><A><R><M><L><R><E><Y><Q><E><L><M><S><L><K><L><A><L><D><M><E><I><A><T><Y><R><K><L><L><E><G><E><E><C><R><M><S><G><E><N><P><S><S><V><S><I><S><V><I><S><S><S><S><Y><S><Y><H><H><P><S><S><A><G><V><D><L><G><A><S><A><V><A><G><S><S><G><S><T><Q><S><G><Q><T><K><T><T><E><A><R><G><G><D><L><K><D><T><Q><G><K><S><T><P><A><S><I><P><A><R><K><A><T><R>
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).<BOP>
Q7RTS7
Q8IU81
I2BP1_HUMAN
Probable RING-type E3 ubiquitin transferase IRF2BP1
Homo
<M><A><S><V><Q><A><S><R><R><Q><W><C><Y><L><C><D><L><P><K><M><P><W><A><M><V><W><D><F><S><E><A><V><C><R><G><C><V><N><F><E><G><A><D><R><I><E><L><L><I><D><A><A><R><Q><L><K><R><S><H><V><L><P><E><G><R><S><P><G><P><P><A><L><K><H><P><A><T><K><D><L><A><A><A><A><A><Q><G><P><Q><L><P><P><P><Q><A><Q><P><Q><P><S><G><T><G><G><G><V><S><G><Q><D><R><Y><D><R><A><T><S><S><G><R><L><P><L><P><S><P><A><L><E><Y><T><L><G><S><R><L><A><N><G><L><G><R><E><E><A><V><A><E><G><A><R><R><A><L><L><G><S><M><P><G><L><M><P><P><G><L><L><A><A><A><V><S><G><L><G><S><R><G><L><T><L><A><P><G><L><S><P><A><R><P><L><F><G><S><D><F><E><K><E><K><Q><Q><R><N><A><D><C><L><A><E><L><N><E><A><M><R><G><R><A><E><E><W><H><G><R><P><K><A><V><R><E><Q><L><L><A><L><S><A><C><A><P><F><N><V><R><F><K><K><D><H><G><L><V><G><R><V><F><A><F><D><A><T><A><R><P><P><G><Y><E><F><E><L><K><L><F><T><E><Y><P><C><G><S><G><N><V><Y><A><G><V><L><A><V><A><R><Q><M><F><H><D><A><L><R><E><P><G><K><A><L><A><S><S><G><F><K><Y><L><E><Y><E><R><R><H><G><S><G><E><W><R><Q><L><G><E><L><L><T><D><G><V><R><S><F><R><E><P><A><P><A><E><A><L><P><Q><Q><Y><P><E><P><A><P><A><A><L><C><G><P><P><P><R><A><P><S><R><N><L><A><P><T><P><R><R><R><K><A><S><P><E><P><E><G><E><A><A><G><K><M><T><T><E><E><Q><Q><Q><R><H><W><V><A><P><G><G><P><Y><S><A><E><T><P><G><V><P><S><P><I><A><A><L><K><N><V><A><E><A><L><G><H><S><P><K><D><P><G><G><G><G><G><P><V><R><A><G><G><A><S><P><A><A><S><S><T><A><Q><P><P><T><Q><H><R><L><V><A><R><N><G><E><A><E><V><S><P><T><A><G><A><E><A><V><S><G><G><G><S><G><T><G><A><T><P><G><A><P><L><C><C><T><L><C><R><E><R><L><E><D><T><H><F><V><Q><C><P><S><V><P><G><H><K><F><C><F><P><C><S><R><E><F><I><K><A><Q><G><P><A><G><E><V><Y><C><P><S><G><D><K><C><P><L><V><G><S><S><V><P><W><A><F><M><Q><G><E><I><A><T><I><L><A><G><D><I><K><V><K><K><E><R><D><P>
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.<BOP>
Q8IU81
P40925
MDHC_HUMAN
Cytosolic malate dehydrogenase
Homo
<M><S><E><P><I><R><V><L><V><T><G><A><A><G><Q><I><A><Y><S><L><L><Y><S><I><G><N><G><S><V><F><G><K><D><Q><P><I><I><L><V><L><L><D><I><T><P><M><M><G><V><L><D><G><V><L><M><E><L><Q><D><C><A><L><P><L><L><K><D><V><I><A><T><D><K><E><D><V><A><F><K><D><L><D><V><A><I><L><V><G><S><M><P><R><R><E><G><M><E><R><K><D><L><L><K><A><N><V><K><I><F><K><S><Q><G><A><A><L><D><K><Y><A><K><K><S><V><K><V><I><V><V><G><N><P><A><N><T><N><C><L><T><A><S><K><S><A><P><S><I><P><K><E><N><F><S><C><L><T><R><L><D><H><N><R><A><K><A><Q><I><A><L><K><L><G><V><T><A><N><D><V><K><N><V><I><I><W><G><N><H><S><S><T><Q><Y><P><D><V><N><H><A><K><V><K><L><Q><G><K><E><V><G><V><Y><E><A><L><K><D><D><S><W><L><K><G><E><F><V><T><T><V><Q><Q><R><G><A><A><V><I><K><A><R><K><L><S><S><A><M><S><A><A><K><A><I><C><D><H><V><R><D><I><W><F><G><T><P><E><G><E><F><V><S><M><G><V><I><S><D><G><N><S><Y><G><V><P><D><D><L><L><Y><S><F><P><V><V><I><K><N><K><T><W><K><F><V><E><G><L><P><I><N><D><F><S><R><E><K><M><D><L><T><A><K><E><L><T><E><E><K><E><S><A><F><E><F><L><S><S><A>
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH . Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation .<BOP>
P40925
A0A0A6YYK7
TVA19_HUMAN
T-cell receptor alpha chain V region HPB-MLT
Homo
<M><L><T><A><S><L><L><R><A><V><I><A><S><I><C><V><V><S><S><M><A><Q><K><V><T><Q><A><Q><T><E><I><S><V><V><E><K><E><D><V><T><L><D><C><V><Y><E><T><R><D><T><T><Y><Y><L><F><W><Y><K><Q><P><P><S><G><E><L><V><F><L><I><R><R><N><S><F><D><E><Q><N><E><I><S><G><R><Y><S><W><N><F><Q><K><S><T><S><S><F><N><F><T><I><T><A><S><Q><V><V><D><S><A><V><Y><F><C><A><L><S><E>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0A6YYK7
Q9H963
ZN702_HUMAN
Putative zinc finger protein 702
Homo
<M><R><E><K><S><F><Q><C><N><E><S><G><K><A><F><N><C><S><S><L><L><K><K><C><Q><I><I><H><L><G><E><K><K><Y><K><C><D><I><C><G><K><V><F><N><Q><K><R><Y><L><A><Y><H><H><R><C><H><T><G><E><K><P><Y><K><C><N><Q><C><G><K><T><F><S><Y><K><S><S><L><V><I><H><K><A><I><H><T><G><E><K><P><H><K><C><N><E><C><G><K><V><F><N><Q><K><A><Y><L><A><S><H><H><R><L><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><V><F><S><R>
May be involved in transcriptional regulation.<BOP>
Q9H963
P43356
MAGA2_HUMAN
MAGE-2 antigen
Homo
<M><P><L><E><Q><R><S><Q><H><C><K><P><E><E><G><L><E><A><R><G><E><A><L><G><L><V><G><A><Q><A><P><A><T><E><E><Q><Q><T><A><S><S><S><S><T><L><V><E><V><T><L><G><E><V><P><A><A><D><S><P><S><P><P><H><S><P><Q><G><A><S><S><F><S><T><T><I><N><Y><T><L><W><R><Q><S><D><E><G><S><S><N><Q><E><E><E><G><P><R><M><F><P><D><L><E><S><E><F><Q><A><A><I><S><R><K><M><V><E><L><V><H><F><L><L><L><K><Y><R><A><R><E><P><V><T><K><A><E><M><L><E><S><V><L><R><N><C><Q><D><F><F><P><V><I><F><S><K><A><S><E><Y><L><Q><L><V><F><G><I><E><V><V><E><V><V><P><I><S><H><L><Y><I><L><V><T><C><L><G><L><S><Y><D><G><L><L><G><D><N><Q><V><M><P><K><T><G><L><L><I><I><V><L><A><I><I><A><I><E><G><D><C><A><P><E><E><K><I><W><E><E><L><S><M><L><E><V><F><E><G><R><E><D><S><V><F><A><H><P><R><K><L><L><M><Q><D><L><V><Q><E><N><Y><L><E><Y><R><Q><V><P><G><S><D><P><A><C><Y><E><F><L><W><G><P><R><A><L><I><E><T><S><Y><V><K><V><L><H><H><T><L><K><I><G><G><E><P><H><I><S><Y><P><P><L><H><E><R><A><L><R><E><G><E><E>
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.<BOP>
P43356
Q9Y6I9
TX264_HUMAN
Putative secreted protein Zsig11
Homo
<M><S><D><L><L><L><L><G><L><I><G><G><L><T><L><L><L><L><L><T><L><L><A><F><A><G><Y><S><G><L><L><A><G><V><E><V><S><A><G><S><P><P><I><R><N><V><T><V><A><Y><K><F><H><M><G><L><Y><G><E><T><G><R><L><F><T><E><S><C><S><I><S><P><K><L><R><S><I><A><V><Y><Y><D><N><P><H><M><V><P><P><D><K><C><R><C><A><V><G><S><I><L><S><E><G><E><E><S><P><S><P><E><L><I><D><L><Y><Q><K><F><G><F><K><V><F><S><F><P><A><P><S><H><V><V><T><A><T><F><P><Y><T><T><I><L><S><I><W><L><A><T><R><R><V><H><P><A><L><D><T><Y><I><K><E><R><K><L><C><A><Y><P><R><L><E><I><Y><Q><E><D><Q><I><H><F><M><C><P><L><A><R><Q><G><D><F><Y><V><P><E><M><K><E><T><E><W><K><W><R><G><L><V><E><A><I><D><T><Q><V><D><G><T><G><A><D><T><M><S><D><T><S><S><V><S><L><E><V><S><P><G><S><R><E><T><S><A><A><T><L><S><P><G><A><S><S><R><G><W><D><D><G><D><T><R><S><E><H><S><Y><S><E><S><G><A><S><G><S><S><F><E><E><L><D><L><E><G><E><G><P><L><G><E><S><R><L><D><P><G><T><E><P><L><G><T><T><K><W><L><W><E><P><T><A><P><E><K><G><K><E>
Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins . Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure . Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN .<BOP>
Q9Y6I9
Q13685
AAMP_HUMAN
Angio-associated migratory cell protein
Homo
<M><E><S><E><S><E><S><G><A><A><A><D><T><P><P><L><E><T><L><S><F><H><G><D><E><E><I><I><E><V><V><E><L><D><P><G><P><P><D><P><D><D><L><A><Q><E><M><E><D><V><D><F><E><E><E><E><E><E><E><G><N><E><E><G><W><V><L><E><P><Q><E><G><V><V><G><S><M><E><G><P><D><D><S><E><V><T><F><A><L><H><S><A><S><V><F><C><V><S><L><D><P><K><T><N><T><L><A><V><T><G><G><E><D><D><K><A><F><V><W><R><L><S><D><G><E><L><L><F><E><C><A><G><H><K><D><S><V><T><C><A><G><F><S><H><D><S><T><L><V><A><T><G><D><M><S><G><L><L><K><V><W><Q><V><D><T><K><E><E><V><W><S><F><E><A><G><D><L><E><W><M><E><W><H><P><R><A><P><V><L><L><A><G><T><A><D><G><N><T><W><M><W><K><V><P><N><G><D><C><K><T><F><Q><G><P><N><C><P><A><T><C><G><R><V><L><P><D><G><K><R><A><V><V><G><Y><E><D><G><T><I><R><I><W><D><L><K><Q><G><S><P><I><H><V><L><K><G><T><E><G><H><Q><G><P><L><T><C><V><A><A><N><Q><D><G><S><L><I><L><T><G><S><V><D><C><Q><A><K><L><V><S><A><T><T><G><K><V><V><G><V><F><R><P><E><T><V><A><S><Q><P><S><L><G><E><G><E><E><S><E><S><N><S><V><E><S><L><G><F><C><S><V><M><P><L><A><A><V><G><Y><L><D><G><T><L><A><I><Y><D><L><A><T><Q><T><L><R><H><Q><C><Q><H><Q><S><G><I><V><Q><L><L><W><E><A><G><T><A><V><V><Y><T><C><S><L><D><G><I><V><R><L><W><D><A><R><T><G><R><L><L><T><D><Y><R><G><H><T><A><E><I><L><D><F><A><L><S><K><D><A><S><L><V><V><T><T><S><G><D><H><K><A><K><V><F><C><V><Q><R><P><D><R>
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.<BOP>
Q13685
Q6P656
CF161_HUMAN
Cilia- and flagella-associated protein 161
Homo
<M><A><Q><N><V><Y><G><P><G><V><R><I><G><N><W><N><E><D><V><Y><L><E><E><E><L><M><K><D><F><L><E><K><R><D><K><G><K><L><L><I><Q><R><S><R><R><L><K><Q><N><L><L><R><P><M><Q><L><S><V><T><E><D><G><Y><I><H><Y><G><D><K><V><M><L><V><N><P><D><D><P><D><T><E><A><D><V><F><L><R><G><D><L><S><L><C><M><T><P><D><E><I><Q><S><H><L><K><D><E><L><E><V><P><C><G><L><S><A><V><Q><A><K><T><P><I><G><R><N><T><F><I><I><L><S><V><H><R><D><A><T><G><Q><V><L><R><Y><G><Q><D><F><C><L><G><I><T><G><G><F><D><N><K><M><L><Y><L><S><S><D><H><R><T><L><L><K><S><S><K><R><S><W><L><Q><E><V><Y><L><T><D><E><V><S><H><V><N><C><W><Q><A><A><F><P><D><P><Q><L><R><L><E><Y><E><G><F><P><V><P><A><N><A><K><I><L><I><N><H><C><H><T><N><R><G><L><A><A><H><R><H><L><F><L><S><T><Y><F><G><K><E><A><E><V><V><A><H><T><Y><L><D><S><H><R><V><E><K><P><R><N><H><W><M><L><V><T><G><N><P><R><D><A><S><S><S><M><L><D><L><P><K><P><P><T><E><D><T><R><A><M><E><Q><A><M><G><L><D><T><Q>
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP>
Q6P656
Q8N5W9
RFLB_HUMAN
Regulator of filamin protein B
Homo
<M><V><G><R><L><S><L><Q><D><V><P><E><L><V><D><A><K><K><K><G><D><G><V><L><D><S><P><D><S><G><L><P><P><S><P><S><P><S><H><W><G><L><A><A><G><G><G><G><G><E><R><A><A><A><P><G><T><L><E><P><D><A><A><A><A><T><P><A><A><P><S><P><A><S><L><P><L><A><P><G><C><A><L><R><L><C><P><L><S><F><G><E><G><V><E><F><D><P><L><P><P><K><E><V><R><Y><T><S><L><V><K><Y><D><S><E><R><H><F><I><D><D><V><Q><L><P><L><G><L><A><V><A><S><C><S><Q><T><V><T><C><V><P><N><G><T><W><R><N><Y><K><A><E><V><R><F><E><P><R><H><R><P><T><R><F><L><S><T><T><I><V><Y><P><K><Y><P><K><A><V><Y><T><T><T><L><D><Y><N><C><R><K><T><L><R><R><F><L><S><S><V><E><L><E><A><A><E><L><P><G><S><D><D><L><S><D><E><C>
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements.<BOP>
Q8N5W9
Q4G163
FBX43_HUMAN
Endogenous meiotic inhibitor 2
Homo
<M><S><F><K><D><K><D><E><R><I><S><C><L><E><A><Y><V><T><L><T><S><K><S><S><R><F><T><D><E><T><E><I><L><K><M><S><Q><R><H><S><G><Q><A><G><T><E><A><G><N><G><A><D><S><P><P><I><V><N><S><K><Y><S><T><F><R><D><F><C><S><T><S><S><F><Q><D><S><G><Y><N><E><L><K><S><C><S><F><D><N><I><D><K><E><Y><L><G><K><K><E><K><G><P><T><L><L><Y><E><H><P><E><T><S><G><L><G><L><T><H><P><L><E><S><P><T><Q><K><K><K><C><I><L><P><R><K><E><K><D><K><T><P><E><L><C><E><T><P><K><I><S><G><K><K><C><L><P><R><R><R><L><N><V><S><F><A><L><L><K><G><D><F><E><S><Q><N><S><S><L><E><S><S><I><S><Q><V><I><N><L><E><K><N><I><P><S><S><A><S><G><F><S><R><A><N><N><F><S><P><L><V><T><S><T><L><K><T><E><E><V><T><S><C><S><Q><K><L><R><L><N><F><S><Q><Q><K><T><S><T><I><D><D><S><K><D><D><C><S><L><F><E><V><E><C><I><S><P><I><Q><G><N><N><F><K><D><S><I><T><H><D><F><S><D><S><S><L><C><I><N><D><E><N><A><C><P><E><L><L><G><S><S><V><S><G><T><T><C><G><T><D><E><D><I><F><V><T><P><I><S><N><L><V><A><N><I><R><F><N><A><S><Q><I><L><S><P><S><P><E><V><R><G><S><I><S><T><P><E><D><S><G><F><N><S><L><S><L><E><K><S><E><D><S><L><S><D><Q><E><G><S><F><Q><E><L><L><Q><K><H><K><G><T><P><K><V><G><D><T><I><R><K><T><R><H><L><G><R><S><R><R><L><S><T><L><R><E><Q><S><S><Q><S><E><T><E><E><E><K><Q><I><V><H><P><D><S><E><K><R><A><A><A><A><S><A><I><S><E><G><Q><L><S><S><D><E><S><G><D><L><T><F><S><L><K><N><L><S><K><T><P><A><L><Q><L><V><H><E><L><F><M><K><S><K><R><K><R><L><Q><E><N><S><G><H><E><F><L><E><Q><G><D><G><E><K><I><A><V><L><Q><C><I><L><A><G><L><I><G><K><K><M><G><I><E><K><L><D><I><L><T><E><L><K><Y><R><N><L><K><H><I><L><A><M><V><L><E><S><L><T><A><E><S><L><C><S><V><W><K><V><S><R><N><W><R><E><I><V><V><Q><D><K><N><A><N><R><R><R><K><F><Y><I><T><Q><L><K><T><D><S><E><G><A><V><L><N><V><E><D><A><A><T><R><L><Q><L><L><N><R><S><A><L><R><S><V><Q><A><Q><A><R><I><P><G><S><Q><R><E><Q><G><S><T><L><S><P><W><G><E><V><L><T><P><L><A><S><S><S><V><T><H><L><S><S><K><Q><E><E><Y><V><K><V><A><K><T><L><F><T><D><E><A><L><K><P><C><P><R><C><Q><S><P><A><K><Y><Q><P><Y><K><K><R><G><L><C><S><R><T><A><C><G><F><D><F><C><V><L><C><L><C><A><Y><H><G><S><E><E><C><S><R><G><A><A><K><P><R><N><R><K><D><A><L><P><G><S><A><Q><S><K><R><N><L><K><R><L>
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation . Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis.<BOP>
Q4G163
Q8N335
GPD1L_HUMAN
Glycerol-3-phosphate dehydrogenase 1-like protein
Homo
<M><A><A><A><P><L><K><V><C><I><V><G><S><G><N><W><G><S><A><V><A><K><I><I><G><N><N><V><K><K><L><Q><K><F><A><S><T><V><K><M><W><V><F><E><E><T><V><N><G><R><K><L><T><D><I><I><N><N><D><H><E><N><V><K><Y><L><P><G><H><K><L><P><E><N><V><V><A><M><S><N><L><S><E><A><V><Q><D><A><D><L><L><V><F><V><I><P><H><Q><F><I><H><R><I><C><D><E><I><T><G><R><V><P><K><K><A><L><G><I><T><L><I><K><G><I><D><E><G><P><E><G><L><K><L><I><S><D><I><I><R><E><K><M><G><I><D><I><S><V><L><M><G><A><N><I><A><N><E><V><A><A><E><K><F><C><E><T><T><I><G><S><K><V><M><E><N><G><L><L><F><K><E><L><L><Q><T><P><N><F><R><I><T><V><V><D><D><A><D><T><V><E><L><C><G><A><L><K><N><I><V><A><V><G><A><G><F><C><D><G><L><R><C><G><D><N><T><K><A><A><V><I><R><L><G><L><M><E><M><I><A><F><A><R><I><F><C><K><G><Q><V><S><T><A><T><F><L><E><S><C><G><V><A><D><L><I><T><T><C><Y><G><G><R><N><R><R><V><A><E><A><F><A><R><T><G><K><T><I><E><E><L><E><K><E><M><L><N><G><Q><K><L><Q><G><P><Q><T><S><A><E><V><Y><R><I><L><K><Q><K><G><L><L><D><K><F><P><L><F><T><A><V><Y><Q><I><C><Y><E><S><R><P><V><Q><E><M><L><S><C><L><Q><S><H><P><E><H><T>
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.<BOP>
Q8N335
Q96SC8
DMTA2_HUMAN
Doublesex- and mab-3-related transcription factor 5
Homo
<M><E><L><R><S><E><L><P><S><V><P><G><A><A><T><A><A><A><A><T><A><T><G><P><P><V><A><S><V><A><S><V><A><A><A><A><A><A><A><A><S><L><P><V><S><V><A><G><G><L><L><R><G><P><P><L><L><L><R><A><A><E><K><Y><P><R><T><P><K><C><A><R><C><R><N><H><G><V><V><S><A><L><K><G><H><K><R><Y><C><R><W><K><D><C><L><C><A><K><C><T><L><I><A><E><R><Q><R><V><M><A><A><Q><V><A><L><R><R><Q><Q><A><Q><E><E><N><E><A><R><E><L><Q><L><L><Y><G><T><A><E><G><L><A><L><A><A><A><N><G><I><I><P><P><R><P><A><Y><E><V><F><G><S><V><C><A><A><D><G><G><G><P><G><A><G><A><P><A><G><T><G><G><G><A><A><G><A><G><G><S><E><A><K><L><Q><K><F><D><L><F><P><K><T><L><L><Q><A><G><R><P><G><S><P><L><P><P><P><V><K><P><L><S><P><D><G><A><D><S><G><P><G><T><S><S><P><E><V><R><P><G><S><G><S><E><N><G><D><G><E><S><F><S><G><S><P><L><A><R><A><S><K><E><A><G><G><S><C><P><G><S><A><G><P><G><G><G><G><E><E><D><S><P><G><S><A><S><P><L><G><S><E><S><G><S><E><A><D><K><E><E><G><E><A><A><P><A><P><G><L><G><G><G><S><G><P><R><Q><R><T><P><L><D><I><L><T><R><V><F><P><G><H><R><R><G><V><L><E><L><V><L><Q><G><C><G><G><D><V><V><Q><A><I><E><Q><V><L><N><H><H><R><G><G><L><A><A><G><L><G><P><A><A><P><P><D><K><A><A><V><G><A><A><A><A><A><D><D><A><W><P><S><R><V><D><A><A><A><A><A><A><A><A><A><G><G><P><G><L><P><A><P><L><Q><A><G><P><A><A><P><P><H><H><R><P><L><L><A><G><A><M><A><P><G><A><L><G><S><L><S><S><R><S><A><F><S><P><L><Q><P><N><A><S><H><F><G><A><D><A><G><A><Y><P><L><G><A><P><L><G><L><S><P><L><R><L><A><Y><S><A><A><A><A><H><S><R><G><L><A><F><M><A><P><Y><S><T><A><G><L><V><P><T><L><G><F><R><P><P><M><D><Y><A><F><S><D><L><M><R><D><R><S><A><A><A><A><A><A><V><H><K><E><P><T><Y><G><G><G><L><Y><G><P><M><V><N><G><A><P><E><K><Q>
May be involved in sexual development.<BOP>
Q96SC8
Q9UKL6
PPCT_HUMAN
StAR-related lipid transfer protein 2
Homo
<M><E><L><A><A><G><S><F><S><E><E><Q><F><W><E><A><C><A><E><L><Q><Q><P><A><L><A><G><A><D><W><Q><L><L><V><E><T><S><G><I><S><I><Y><R><L><L><D><K><K><T><G><L><Y><E><Y><K><V><F><G><V><L><E><D><C><S><P><T><L><L><A><D><I><Y><M><D><S><D><Y><R><K><Q><W><D><Q><Y><V><K><E><L><Y><E><Q><E><C><N><G><E><T><V><V><Y><W><E><V><K><Y><P><F><P><M><S><N><R><D><Y><V><Y><L><R><Q><R><R><D><L><D><M><E><G><R><K><I><H><V><I><L><A><R><S><T><S><M><P><Q><L><G><E><R><S><G><V><I><R><V><K><Q><Y><K><Q><S><L><A><I><E><S><D><G><K><K><G><S><K><V><F><M><Y><Y><F><D><N><P><G><G><Q><I><P><S><W><L><I><N><W><A><A><K><N><G><V><P><N><F><L><K><D><M><A><R><A><C><Q><N><Y><L><K><K><T>
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.<BOP>
Q9UKL6
Q9Y3I1
FBX7_HUMAN
F-box only protein 7
Homo
<M><R><L><R><V><R><L><L><K><R><T><W><P><L><E><V><P><E><T><E><P><T><L><G><H><L><R><S><H><L><R><Q><S><L><L><C><T><W><G><Y><S><S><N><T><R><F><T><I><T><L><N><Y><K><D><P><L><T><G><D><E><E><T><L><A><S><Y><G><I><V><S><G><D><L><I><C><L><I><L><Q><D><D><I><P><A><P><N><I><P><S><S><T><D><S><E><H><S><S><L><Q><N><N><E><Q><P><S><L><A><T><S><S><N><Q><T><S><M><Q><D><E><Q><P><S><D><S><F><Q><G><Q><A><A><Q><S><G><V><W><N><D><D><S><M><L><G><P><S><Q><N><F><E><A><E><S><I><Q><D><N><A><H><M><A><E><G><T><G><F><Y><P><S><E><P><M><L><C><S><E><S><V><E><G><Q><V><P><H><S><L><E><T><L><Y><Q><S><A><D><C><S><D><A><N><D><A><L><I><V><L><I><H><L><L><M><L><E><S><G><Y><I><P><Q><G><T><E><A><K><A><L><S><M><P><E><K><W><K><L><S><G><V><Y><K><L><Q><Y><M><H><P><L><C><E><G><S><S><A><T><L><T><C><V><P><L><G><N><L><I><V><V><N><A><T><L><K><I><N><N><E><I><R><S><V><K><R><L><Q><L><L><P><E><S><F><I><C><K><E><K><L><G><E><N><V><A><N><I><Y><K><D><L><Q><K><L><S><R><L><F><K><D><Q><L><V><Y><P><L><L><A><F><T><R><Q><A><L><N><L><P><D><V><F><G><L><V><V><L><P><L><E><L><K><L><R><I><F><R><L><L><D><V><R><S><V><L><S><L><S><A><V><C><R><D><L><F><T><A><S><N><D><P><L><L><W><R><F><L><Y><L><R><D><F><R><D><N><T><V><R><V><Q><D><T><D><W><K><E><L><Y><R><K><R><H><I><Q><R><K><E><S><P><K><G><R><F><V><M><L><L><P><S><S><T><H><T><I><P><F><Y><P><N><P><L><H><P><R><P><F><P><S><S><R><L><P><P><G><I><I><G><G><E><Y><D><Q><R><P><T><L><P><Y><V><G><D><P><I><S><S><L><I><P><G><P><G><E><T><P><S><Q><F><P><P><L><R><P><R><F><D><P><V><G><P><L><P><G><P><N><P><I><L><P><G><R><G><G><P><N><D><R><F><P><F><R><P><S><R><G><R><P><T><D><G><R><L><S><F><M>
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.<BOP>
Q9Y3I1
Q15404
RSU1_HUMAN
Ras suppressor protein 1
Homo
<M><S><K><S><L><K><K><L><V><E><E><S><R><E><K><N><Q><P><E><V><D><M><S><D><R><G><I><S><N><M><L><D><V><N><G><L><F><T><L><S><H><I><T><Q><L><V><L><S><H><N><K><L><T><M><V><P><P><N><I><A><E><L><K><N><L><E><V><L><N><F><F><N><N><Q><I><E><E><L><P><T><Q><I><S><S><L><Q><K><L><K><H><L><N><L><G><M><N><R><L><N><T><L><P><R><G><F><G><S><L><P><A><L><E><V><L><D><L><T><Y><N><N><L><S><E><N><S><L><P><G><N><F><F><Y><L><T><T><L><R><A><L><Y><L><S><D><N><D><F><E><I><L><P><P><D><I><G><K><L><T><K><L><Q><I><L><S><L><R><D><N><D><L><I><S><L><P><K><E><I><G><E><L><T><Q><L><K><E><L><H><I><Q><G><N><R><L><T><V><L><P><P><E><L><G><N><L><D><L><T><G><Q><K><Q><V><F><K><A><E><N><N><P><W><V><T><P><I><A><D><Q><F><Q><L><G><V><S><H><V><F><E><Y><I><R><S><E><T><Y><K><Y><L><Y><G><R><H><M><Q><A><N><P><E><P><P><K><K><N><N><D><K><S><K><K><I><S><R><K><P><L><A><A><K><N><R>
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.<BOP>
Q15404
Q96GK7
FAH2A_HUMAN
Fumarylacetoacetate hydrolase domain-containing protein 2A
Homo
<M><L><V><S><G><R><R><R><L><L><T><V><L><L><Q><A><Q><K><W><P><F><Q><P><S><R><D><M><R><L><V><Q><F><R><A><P><H><L><V><G><P><H><L><G><L><E><T><G><N><G><G><G><V><I><N><L><N><A><F><D><P><T><L><P><K><T><M><T><Q><F><L><E><Q><G><E><A><T><L><S><V><A><R><R><A><L><A><A><Q><L><P><V><L><P><R><S><E><V><T><F><L><A><P><V><T><R><P><D><K><V><V><C><V><G><M><N><Y><V><D><H><C><K><E><Q><N><V><P><V><P><K><E><P><I><I><F><S><K><F><A><S><S><I><V><G><P><Y><D><E><V><V><L><P><P><Q><S><Q><E><V><D><W><E><V><E><L><A><V><V><I><G><K><K><G><K><H><I><K><A><T><D><A><M><A><H><V><A><G><F><T><V><A><H><D><V><S><A><R><D><W><Q><M><R><R><N><G><K><Q><W><L><L><G><K><T><F><D><T><F><C><P><L><G><P><A><L><V><T><K><D><S><V><A><D><P><H><N><L><K><I><C><C><R><V><N><G><E><V><V><Q><S><G><N><T><N><Q><M><V><F><K><T><E><D><L><I><A><W><V><S><Q><F><V><T><F><Y><P><G><D><V><I><L><T><G><T><P><P><G><V><G><V><F><R><K><P><P><V><F><L><K><K><G><D><E><V><Q><C><E><I><E><E><L><G><V><I><I><N><K><V><V>
May have hydrolase activity.<BOP>
Q96GK7
Q9ULA0
DNPEP_HUMAN
Aspartyl aminopeptidase
Homo
<M><S><G><H><S><P><T><R><G><A><M><Q><V><A><M><N><G><K><A><R><K><E><A><V><Q><T><A><A><K><E><L><L><K><F><V><N><R><S><P><S><P><F><H><A><V><A><E><C><R><N><R><L><L><Q><A><G><F><S><E><L><K><E><T><E><K><W><N><I><K><P><E><S><K><Y><F><M><T><R><N><S><S><T><I><I><A><F><A><V><G><G><Q><Y><V><P><G><N><G><F><S><L><I><G><A><H><T><D><S><P><C><L><R><V><K><R><R><S><R><R><S><Q><V><G><F><Q><Q><V><G><V><E><T><Y><G><G><G><I><W><S><T><W><F><D><R><D><L><T><L><A><G><R><V><I><V><K><C><P><T><S><G><R><L><E><Q><Q><L><V><H><V><E><R><P><I><L><R><I><P><H><L><A><I><H><L><Q><R><N><I><N><E><N><F><G><P><N><T><E><M><H><L><V><P><I><L><A><T><A><I><Q><E><E><L><E><K><G><T><P><E><P><G><P><L><N><A><V><D><E><R><H><H><S><V><L><M><S><L><L><C><A><H><L><G><L><S><P><K><D><I><V><E><M><E><L><C><L><A><D><T><Q><P><A><V><L><G><G><A><Y><D><E><F><I><F><A><P><R><L><D><N><L><H><S><C><F><C><A><L><Q><A><L><I><D><S><C><A><G><P><G><S><L><A><T><E><P><H><V><R><M><V><T><L><Y><D><N><E><E><V><G><S><E><S><A><Q><G><A><Q><S><L><L><T><E><L><V><L><R><R><I><S><A><S><C><Q><H><P><T><A><F><E><E><A><I><P><K><S><F><M><I><S><A><D><M><A><H><A><V><H><P><N><Y><L><D><K><H><E><E><N><H><R><P><L><F><H><K><G><P><V><I><K><V><N><S><K><Q><R><Y><A><S><N><A><V><S><E><A><L><I><R><E><V><A><N><K><V><K><V><P><L><Q><D><L><M><V><R><N><D><T><P><C><G><T><T><I><G><P><I><L><A><S><R><L><G><L><R><V><L><D><L><G><S><P><Q><L><A><M><H><S><I><R><E><M><A><C><T><T><G><V><L><Q><T><L><T><L><F><K><G><F><F><E><L><F><P><S><L><S><H><N><L><L><V><D>
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.<BOP>
Q9ULA0
P51003
PAPOA_HUMAN
Polynucleotide adenylyltransferase alpha
Homo
<M><P><F><P><V><T><T><Q><G><S><Q><Q><T><Q><P><P><Q><K><H><Y><G><I><T><S><P><I><S><L><A><A><P><K><E><T><D><C><V><L><T><Q><K><L><I><E><T><L><K><P><F><G><V><F><E><E><E><E><E><L><Q><R><R><I><L><I><L><G><K><L><N><N><L><V><K><E><W><I><R><E><I><S><E><S><K><N><L><P><Q><S><V><I><E><N><V><G><G><K><I><F><T><F><G><S><Y><R><L><G><V><H><T><K><G><A><D><I><D><A><L><C><V><A><P><R><H><V><D><R><S><D><F><F><T><S><F><Y><D><K><L><K><L><Q><E><E><V><K><D><L><R><A><V><E><E><A><F><V><P><V><I><K><L><C><F><D><G><I><E><I><D><I><L><F><A><R><L><A><L><Q><T><I><P><E><D><L><D><L><R><D><D><S><L><L><K><N><L><D><I><R><C><I><R><S><L><N><G><C><R><V><T><D><E><I><L><H><L><V><P><N><I><D><N><F><R><L><T><L><R><A><I><K><L><W><A><K><R><H><N><I><Y><S><N><I><L><G><F><L><G><G><V><S><W><A><M><L><V><A><R><T><C><Q><L><Y><P><N><A><I><A><S><T><L><V><H><K><F><F><L><V><F><S><K><W><E><W><P><N><P><V><L><L><K><Q><P><E><E><C><N><L><N><L><P><V><W><D><P><R><V><N><P><S><D><R><Y><H><L><M><P><I><I><T><P><A><Y><P><Q><Q><N><S><T><Y><N><V><S><V><S><T><R><M><V><M><V><E><E><F><K><Q><G><L><A><I><T><D><E><I><L><L><S><K><A><E><W><S><K><L><F><E><A><P><N><F><F><Q><K><Y><K><H><Y><I><V><L><L><A><S><A><P><T><E><K><Q><R><L><E><W><V><G><L><V><E><S><K><I><R><I><L><V><G><S><L><E><K><N><E><F><I><T><L><A><H><V><N><P><Q><S><F><P><A><P><K><E><N><P><D><K><E><E><F><R><T><M><W><V><I><G><L><V><F><K><K><T><E><N><S><E><N><L><S><V><D><L><T><Y><D><I><Q><S><F><T><D><T><V><Y><R><Q><A><I><N><S><K><M><F><E><V><D><M><K><I><A><A><M><H><V><K><R><K><Q><L><H><Q><L><L><P><N><H><V><L><Q><K><K><K><K><H><S><T><E><G><V><K><L><T><A><L><N><D><S><S><L><D><L><S><M><D><S><D><N><S><M><S><V><P><S><P><T><S><A><T><K><T><S><P><L><N><S><S><G><S><S><Q><G><R><N><S><P><A><P><A><V><T><A><A><S><V><T><N><I><Q><A><T><E><V><S><V><P><Q><V><N><S><S><E><S><S><G><G><T><S><S><E><S><I><P><Q><T><A><T><Q><P><A><I><S><P><P><P><K><P><T><V><S><R><V><V><S><S><T><R><L><V><N><P><P><P><R><S><S><G><N><A><A><T><S><G><N><A><A><T><K><I><P><T><P><I><V><G><V><K><R><T><S><S><P><H><K><E><E><S><P><K><K><T><K><T><E><E><D><E><T><S><E><D><A><N><C><L><A><L><S><G><H><D><K><T><E><A><K><E><Q><L><D><T><E><T><S><T><T><Q><S><E><T><I><Q><T><A><A><S><L><L><A><S><Q><K><T><S><S><T><D><L><S><D><I><P><A><L><P><A><N><P><I><P><V><I><K><N><S><I><K><L><R><L><N><R>
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.<BOP>
P51003
P0DJD4
RBY1C_HUMAN
RNA-binding motif protein, Y chromosome, family 1 member C
Homo
<M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><Q><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G><S><L><R><S><A><R><G><S><R><G><G><T><R><G><W><L><P><S><H><E><G><H><L><D><D><G><G><Y><T><P><D><L><K><M><S><Y><S><R><G><L><I><P><V><K><R><G><P><S><S><R><S><G><G><P><P><P><K><K><S><A><P><S><A><V><A><R><S><N><S><W><M><G><S><Q><G><P><M><S><Q><R><R><E><N><Y><G><V><P><P><R><R><A><T><I><S><S><W><R><N><D><R><M><S><T><R><H><D><G><Y><A><T><N><D><G><N><H><P><S><C><Q><E><T><R><D><Y><A><P><P><S><R><G><Y><A><Y><R><D><N><G><H><S><N><R><D><E><H><S><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><D><Y><A><P><P><S><R><G><H><A><Y><R><D><Y><G><H><S><R><R><D><E><S><Y><S><R><G><Y><R><N><R><R><S><S><R><E><T><R><E><Y><A><P><P><S><R><G><H><G><Y><R><D><Y><G><H><S><R><R><H><E><S><Y><S><R><G><Y><R><N><H><P><S><S><R><E><T><R><D><Y><A><P><P><H><R><D><Y><A><Y><R><D><Y><G><H><S><S><W><D><E><H><S><S><R><G><Y><S><Y><H><D><G><Y><G><E><A><L><G><R><D><H><S><E><H><L><S><G><S><S><Y><R><D><A><L><Q><R><Y><G><T><S><H><G><A><P><P><A><R><G><P><R><M><S><Y><G><G><S><T><C><H><A><Y><S><N><T><R><D><R><Y><G><R><S><W><E><S><Y><S><S><C><G><D><F><H><Y><C><D><R><E><H><V><C><R><K><D><Q><R><N><P><P><S><L><G><R><V><L><P><D><P><R><E><A><C><G><S><S><S><Y><V><A><S><I><V><D><G><G><E><S><R><S><E><K><G><D><S><S><R><Y>
RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.<BOP>
P0DJD4
Q15573
TAF1A_HUMAN
Transcription initiation factor SL1/TIF-IB subunit A
Homo
<M><S><D><F><S><E><E><L><K><G><P><V><T><D><D><E><E><V><E><T><S><V><L><S><G><A><G><M><H><F><P><W><L><Q><T><Y><V><E><T><V><A><I><G><G><K><R><R><K><D><F><A><Q><T><T><S><A><C><L><S><F><I><Q><E><A><L><L><K><H><Q><W><Q><Q><A><A><E><Y><M><Y><S><Y><F><Q><T><L><E><D><S><D><S><Y><K><R><Q><A><A><P><E><I><I><W><K><L><G><S><E><I><L><F><Y><H><P><K><S><N><M><E><S><F><N><T><F><A><N><R><M><K><N><I><G><V><M><N><Y><L><K><I><S><L><Q><H><A><L><Y><L><L><H><H><G><M><L><K><D><A><K><R><N><L><S><E><A><E><T><W><R><H><G><E><N><T><S><S><R><E><I><L><I><N><L><I><Q><A><Y><K><G><L><L><Q><Y><Y><T><W><S><E><K><K><M><E><L><S><K><L><D><K><D><D><Y><A><Y><N><A><V><A><Q><D><V><F><N><H><S><W><K><T><S><A><N><I><S><A><L><I><K><I><P><G><V><W><D><P><F><V><K><S><Y><V><E><M><L><E><F><Y><G><D><R><D><G><A><Q><E><V><L><T><N><Y><A><Y><D><E><K><F><P><S><N><P><N><A><H><I><Y><L><Y><N><F><L><K><R><Q><K><A><P><R><S><K><L><I><S><V><L><K><I><L><Y><Q><I><V><P><S><H><K><L><M><L><E><F><H><T><L><L><R><K><S><E><K><E><E><H><R><K><L><G><L><E><V><L><F><G><V><L><D><F><A><G><C><T><K><N><I><T><A><W><K><Y><L><A><K><Y><L><K><N><I><L><M><G><N><H><L><A><W><V><Q><E><E><W><N><S><R><K><N><W><W><P><G><F><H><F><S><Y><F><W><A><K><S><D><W><K><E><D><T><A><L><A><C><E><K><A><F><V><A><G><L><L><L><G><K><G><C><R><Y><F><R><Y><I><L><K><Q><D><H><Q><I><L><G><K><K><I><K><R><M><K><R><S><V><K><K><Y><S><I><V><N><P><R><L>
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.<BOP>
Q15573
P0DN81
O13C7_HUMAN
Olfactory receptor 13C7
Homo
<M><V><S><A><N><Q><T><A><S><V><T><E><F><I><L><L><G><L><S><A><H><P><K><L><E><K><T><F><F><V><L><I><L><L><M><Y><L><V><I><L><L><G><N><G><V><L><I><L><M><T><V><S><N><S><H><L><H><M><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><T><S><S><V><P><L><I><L><D><S><F><L><T><P><R><K><T><I><S><F><S><A><C><A><V><Q><M><F><L><S><F><A><M><G><A><T><E><C><V><L><L><S><M><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><P><V><V><M><S><K><A><A><Y><M><P><K><A><A><G><S><W><V><A><G><S><T><A><S><M><V><Q><T><S><L><A><M><R><L><P><F><C><G><D><N><I><I><N><H><F><T><C><E><I><L><A><V><L><K><L><A><C><A><D><I><S><V><N><V><I><S><M><G><V><T><N><V><I><F><L><G><V><P><V><L><F><I><S><F><S><Y><V><F><I><I><A><T><I><L><R><I><P><S><A><E><G><R><K><K><A><F><S><T><C><S><A><H><L><T><V><V><V><I><F><Y><G><T><I><L><F><M><Y><G><K><P><K><S><K><D><P><L><G><A><D><K><Q><D><L><A><D><K><L><I><S><L><F><Y><G><V><V><T><P><M><L><N><P><I><I><Y><S><L><R><N><K><D><V><K><A><A><V><R><D><L><I><F><Q><K><C><F><A>
Odorant receptor.<BOP>
P0DN81
P08729
K2C7_HUMAN
Type-II keratin Kb7
Homo
<M><S><I><H><F><S><S><P><V><F><T><S><R><S><A><A><F><S><G><R><G><A><Q><V><R><L><S><S><A><R><P><G><G><L><G><S><S><S><L><Y><G><L><G><A><S><R><P><R><V><A><V><R><S><A><Y><G><G><P><V><G><A><G><I><R><E><V><T><I><N><Q><S><L><L><A><P><L><R><L><D><A><D><P><S><L><Q><R><V><R><Q><E><E><S><E><Q><I><K><T><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><K><L><L><E><T><K><W><T><L><L><Q><E><Q><K><S><A><K><S><S><R><L><P><D><I><F><E><A><Q><I><A><G><L><R><G><Q><L><E><A><L><Q><V><D><G><G><R><L><E><A><E><L><R><S><M><Q><D><V><V><E><D><F><K><N><K><Y><E><D><E><I><N><H><R><T><A><A><E><N><E><F><V><V><L><K><K><D><V><D><A><A><Y><M><S><K><V><E><L><E><A><K><V><D><A><L><N><D><E><I><N><F><L><R><T><L><N><E><T><E><L><T><E><L><Q><S><Q><I><S><D><T><S><V><V><L><S><M><D><N><S><R><S><L><D><L><D><G><I><I><A><E><V><K><A><Q><Y><E><E><M><A><K><C><S><R><A><E><A><E><A><W><Y><Q><T><K><F><E><T><L><Q><A><Q><A><G><K><H><G><D><D><L><R><N><T><R><N><E><I><S><E><M><N><R><A><I><Q><R><L><Q><A><E><I><D><N><I><K><N><Q><R><A><K><L><E><A><A><I><A><E><A><E><E><R><G><E><L><A><L><K><D><A><R><A><K><Q><E><E><L><E><A><A><L><Q><R><G><K><Q><D><M><A><R><Q><L><R><E><Y><Q><E><L><M><S><V><K><L><A><L><D><I><E><I><A><T><Y><R><K><L><L><E><G><E><E><S><R><L><A><G><D><G><V><G><A><V><N><I><S><V><M><N><S><T><G><G><S><S><S><G><G><G><I><G><L><T><L><G><G><T><M><G><S><N><A><L><S><F><S><S><S><A><G><P><G><L><L><K><A><Y><S><I><R><T><A><S><A><S><R><R><S><A><R><D>
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).<BOP>
P08729
Q6ZWL3
CP4V2_HUMAN
Long-chain fatty acid omega-monooxygenase
Homo
<M><A><G><L><W><L><G><L><V><W><Q><K><L><L><L><W><G><A><A><S><A><L><S><L><A><G><A><S><L><V><L><S><L><L><Q><R><V><A><S><Y><A><R><K><W><Q><Q><M><R><P><I><P><T><V><A><R><A><Y><P><L><V><G><H><A><L><L><M><K><P><D><G><R><E><F><F><Q><Q><I><I><E><Y><T><E><E><Y><R><H><M><P><L><L><K><L><W><V><G><P><V><P><M><V><A><L><Y><N><A><E><N><V><E><V><I><L><T><S><S><K><Q><I><D><K><S><S><M><Y><K><F><L><E><P><W><L><G><L><G><L><L><T><S><T><G><N><K><W><R><S><R><R><K><M><L><T><P><T><F><H><F><T><I><L><E><D><F><L><D><I><M><N><E><Q><A><N><I><L><V><K><K><L><E><K><H><I><N><Q><E><A><F><N><C><F><F><Y><I><T><L><C><A><L><D><I><I><C><E><T><A><M><G><K><N><I><G><A><Q><S><N><D><D><S><E><Y><V><R><A><V><Y><R><M><S><E><M><I><F><R><R><I><K><M><P><W><L><W><L><D><L><W><Y><L><M><F><K><E><G><W><E><H><K><K><S><L><Q><I><L><H><T><F><T><N><S><V><I><A><E><R><A><N><E><M><N><A><N><E><D><C><R><G><D><G><R><G><S><A><P><S><K><N><K><R><R><A><F><L><D><L><L><L><S><V><T><D><D><E><G><N><R><L><S><H><E><D><I><R><E><E><V><D><T><F><M><F><E><G><H><D><T><T><A><A><A><I><N><W><S><L><Y><L><L><G><S><N><P><E><V><Q><K><K><V><D><H><E><L><D><D><V><F><G><K><S><D><R><P><A><T><V><E><D><L><K><K><L><R><Y><L><E><C><V><I><K><E><T><L><R><L><F><P><S><V><P><L><F><A><R><S><V><S><E><D><C><E><V><A><G><Y><R><V><L><K><G><T><E><A><V><I><I><P><Y><A><L><H><R><D><P><R><Y><F><P><N><P><E><E><F><Q><P><E><R><F><F><P><E><N><A><Q><G><R><H><P><Y><A><Y><V><P><F><S><A><G><P><R><N><C><I><G><Q><K><F><A><V><M><E><E><K><T><I><L><S><C><I><L><R><H><F><W><I><E><S><N><Q><K><R><E><E><L><G><L><E><G><Q><L><I><L><R><P><S><N><G><I><W><I><K><L><K><R><R><N><A><D><E><R>
A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs . Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).<BOP>
Q6ZWL3
Q6JBY9
CPZIP_HUMAN
RCSD domain-containing protein 1
Homo
<M><E><E><R><P><A><E><T><N><A><N><V><D><N><S><A><S><P><S><V><A><Q><L><A><G><R><F><R><E><Q><A><A><A><A><K><E><T><P><A><S><K><P><T><R><R><K><P><P><C><S><L><P><L><F><P><P><K><V><D><L><G><Q><N><G><E><E><K><S><P><P><N><A><S><H><P><P><K><F><K><V><K><S><S><P><L><I><E><K><L><Q><A><N><L><T><F><D><P><A><A><L><L><P><G><A><S><P><K><S><P><G><L><K><A><M><V><S><P><F><H><S><P><P><S><T><P><S><S><P><G><V><R><S><R><P><S><E><A><E><E><V><P><V><S><F><D><Q><P><P><E><G><S><H><L><P><C><Y><N><K><V><R><T><R><G><S><I><K><R><R><P><P><S><R><R><F><R><R><S><Q><S><D><C><G><E><L><G><D><F><R><A><V><E><S><S><Q><Q><N><G><A><K><E><E><D><G><D><E><V><L><P><S><K><S><K><A><P><G><S><P><L><S><S><E><G><A><A><G><E><G><V><R><T><L><G><P><A><E><K><P><P><L><R><R><S><P><S><R><T><E><K><Q><E><E><D><R><A><T><E><E><A><K><N><G><E><K><A><R><R><S><S><E><E><V><D><G><Q><H><P><A><Q><E><E><V><P><E><S><P><Q><T><S><G><P><E><A><E><N><R><C><G><S><P><R><E><E><K><P><A><G><E><E><A><E><M><E><K><A><T><E><V><K><G><E><R><V><Q><N><E><E><V><G><P><E><H><D><S><Q><E><T><K><K><L><E><E><G><A><A><V><K><E><T><P><H><S><P><P><G><G><V><K><G><G><D><V><P><K><Q><E><K><G><K><E><K><Q><Q><E><G><A><V><L><E><P><G><C><S><P><Q><T><G><P><A><Q><L><E><T><S><S><E><V><Q><S><E><P><A><V><P><K><P><E><D><D><T><P><V><Q><D><T><K><M>
Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.<BOP>
Q6JBY9
Q5W0Z9
ZDH20_HUMAN
Zinc finger DHHC domain-containing protein 20
Homo
<M><A><P><W><T><L><W><R><C><C><Q><R><V><V><G><W><V><P><V><L><F><I><T><F><V><V><V><W><S><Y><Y><A><Y><V><V><E><L><C><V><F><T><I><F><G><N><E><E><N><G><K><T><V><V><Y><L><V><A><F><H><L><F><F><V><M><F><V><W><S><Y><W><M><T><I><F><T><S><P><A><S><P><S><K><E><F><Y><L><S><N><S><E><K><E><R><Y><E><K><E><F><S><Q><E><R><Q><Q><E><I><L><R><R><A><A><R><A><L><P><I><Y><T><T><S><A><S><K><T><I><R><Y><C><E><K><C><Q><L><I><K><P><D><R><A><H><H><C><S><A><C><D><S><C><I><L><K><M><D><H><H><C><P><W><V><N><N><C><V><G><F><S><N><Y><K><F><F><L><L><F><L><L><Y><S><L><L><Y><C><L><F><V><A><A><T><V><L><E><Y><F><I><K><F><W><T><N><E><L><T><D><T><R><A><K><F><H><V><L><F><L><F><F><V><S><A><M><F><F><I><S><V><L><S><L><F><S><Y><H><C><W><L><V><G><K><N><R><T><T><I><E><S><F><R><A><P><T><F><S><Y><G><P><D><G><N><G><F><S><L><G><C><S><K><N><W><R><Q><V><F><G><D><E><K><K><Y><W><L><L><P><I><F><S><S><L><G><D><G><C><S><F><P><T><R><L><V><G><M><D><P><E><Q><A><S><V><T><N><Q><N><E><Y><A><R><S><S><G><S><N><Q><P><F><P><I><K><P><L><S><E><S><K><N><R><L><L><D><S><E><S><Q><W><L><E><N><G><A><E><E><G><I><V><K><S><G><T><N><N><H><V><T><V><A><I><E><N>
(Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.<BOP>
Q5W0Z9
P47974
TISD_HUMAN
Zinc finger protein 36, C3H1 type-like 2
Homo
<M><S><T><T><L><L><S><A><F><Y><D><V><D><F><L><C><K><T><E><K><S><L><A><N><L><N><L><N><N><M><L><D><K><K><A><V><G><T><P><V><A><A><A><P><S><S><G><F><A><P><G><F><L><R><R><H><S><A><S><N><L><H><A><L><A><H><P><A><P><S><P><G><S><C><S><P><K><F><P><G><A><A><N><G><S><S><C><G><S><A><A><A><G><G><P><T><S><Y><G><T><L><K><E><P><S><G><G><G><G><T><A><L><L><N><K><E><N><K><F><R><D><R><S><F><S><E><N><G><D><R><S><Q><H><L><L><H><L><Q><Q><Q><Q><K><G><G><G><G><S><Q><I><N><S><T><R><Y><K><T><E><L><C><R><P><F><E><E><S><G><T><C><K><Y><G><E><K><C><Q><F><A><H><G><F><H><E><L><R><S><L><T><R><H><P><K><Y><K><T><E><L><C><R><T><F><H><T><I><G><F><C><P><Y><G><P><R><C><H><F><I><H><N><A><D><E><R><R><P><A><P><S><G><G><A><S><G><D><L><R><A><F><G><T><R><D><A><L><H><L><G><F><P><R><E><P><R><P><K><L><H><H><S><L><S><F><S><G><F><P><S><G><H><H><Q><P><P><G><G><L><E><S><P><L><L><L><D><S><P><T><S><R><T><P><P><P><P><S><C><S><S><A><S><S><C><S><S><S><A><S><S><C><S><S><A><S><A><A><S><T><P><S><G><A><P><T><C><C><A><S><A><A><A><A><A><A><A><A><L><L><Y><G><T><G><G><A><E><D><L><L><A><P><G><A><P><C><A><A><C><S><S><A><S><C><A><N><N><A><F><A><F><G><P><E><L><S><S><L><I><T><P><L><A><I><Q><T><H><N><F><A><A><V><A><A><A><A><Y><Y><R><S><Q><Q><Q><Q><Q><Q><Q><G><L><A><P><P><A><Q><P><P><A><P><P><S><A><T><L><P><A><G><A><A><A><P><P><S><P><P><F><S><F><Q><L><P><R><R><L><S><D><S><P><V><F><D><A><P><P><S><P><P><D><S><L><S><D><R><D><S><Y><L><S><G><S><L><S><S><G><S><L><S><G><S><E><S><P><S><L><D><P><G><R><R><L><P><I><F><S><R><L><S><I><S><D><D>
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis . Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery . Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes . Binds to 3'-UTR ARE of numerous mRNAs . Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner . Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting
P47974
Q8NGY5
OR6N1_HUMAN
Olfactory receptor 6N1
Homo
<M><D><T><G><N><W><S><Q><V><A><E><F><I><I><L><G><F><P><H><L><Q><G><V><Q><I><Y><L><F><L><L><L><L><L><I><Y><L><M><T><V><L><G><N><L><L><I><F><L><V><V><C><L><D><S><R><L><H><T><P><M><Y><H><F><V><S><I><L><S><F><S><E><L><G><Y><T><A><A><T><I><P><K><M><L><A><N><L><L><S><E><K><K><T><I><S><F><S><G><C><L><L><Q><I><Y><F><F><H><S><L><G><A><T><E><C><Y><L><L><T><A><M><A><Y><D><R><Y><L><A><I><C><R><P><L><H><Y><P><T><L><M><T><P><T><L><C><A><E><I><A><I><G><C><W><L><G><G><L><A><G><P><V><V><E><I><S><L><I><S><R><L><P><F><C><G><P><N><R><I><Q><H><V><F><C><D><F><P><P><V><L><S><L><A><C><T><D><T><S><I><N><V><L><V><D><F><V><I><N><S><C><K><I><L><A><T><F><L><L><I><L><C><S><Y><V><Q><I><I><C><T><V><L><R><I><P><S><A><A><G><K><R><K><A><I><S><T><C><A><S><H><F><T><V><V><L><I><F><Y><G><S><I><L><S><M><Y><V><Q><L><K><K><S><Y><S><L><D><Y><D><Q><A><L><A><V><V><Y><S><V><L><T><P><F><L><N><P><F><I><Y><S><L><R><N><K><E><I><K><E><A><V><R><R><Q><L><K><R><I><G><I><L><A>
Odorant receptor.<BOP>
Q8NGY5
Q9NZP5
O5AC2_HUMAN
HSA1
Homo
<M><D><I><S><E><G><N><K><T><L><V><T><E><F><V><L><T><G><L><T><D><R><P><W><L><H><V><L><F><F><V><V><F><L><V><V><Y><L><I><T><M><V><G><N><L><G><L><I><V><L><I><W><N><D><P><H><L><H><M><P><M><Y><L><F><L><G><G><L><A><F><S><D><A><C><T><S><T><S><I><T><P><R><M><L><V><N><F><L><D><K><T><A><M><I><S><L><A><E><C><I><T><Q><F><Y><F><F><A><S><S><A><T><T><E><C><F><L><L><V><M><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><P><V><M><M><S><N><K><L><S><A><Q><L><L><S><I><S><Y><V><I><G><F><L><H><P><L><V><H><V><S><L><L><L><R><L><T><F><C><R><F><N><I><I><H><Y><F><Y><C><E><I><L><Q><L><F><K><I><S><C><N><G><P><S><I><N><A><L><M><I><F><I><F><G><A><F><I><Q><I><P><T><L><M><T><I><I><I><S><Y><T><R><V><L><F><D><I><L><K><K><K><S><E><K><G><R><S><K><A><F><S><T><C><G><A><H><L><L><S><V><S><L><Y><Y><G><T><L><I><F><M><Y><V><R><P><A><S><G><L><A><E><D><Q><D><K><V><Y><S><L><F><Y><T><I><I><I><P><L><L><N><P><F><I><Y><S><L><R><N><K><K><V><M><H><A><L><R><R><V><I><R><K>
Odorant receptor.<BOP>
Q9NZP5
Q15761
NPY5R_HUMAN
NPY-Y5 receptor
Homo
<M><D><L><E><L><D><E><Y><Y><N><K><T><L><A><T><E><N><N><T><A><A><T><R><N><S><D><F><P><V><W><D><D><Y><K><S><S><V><D><D><L><Q><Y><F><L><I><G><L><Y><T><F><V><S><L><L><G><F><M><G><N><L><L><I><L><M><A><L><M><K><K><R><N><Q><K><T><T><V><N><F><L><I><G><N><L><A><F><S><D><I><L><V><V><L><F><C><S><P><F><T><L><T><S><V><L><L><D><Q><W><M><F><G><K><V><M><C><H><I><M><P><F><L><Q><C><V><S><V><L><V><S><T><L><I><L><I><S><I><A><I><V><R><Y><H><M><I><K><H><P><I><S><N><N><L><T><A><N><H><G><Y><F><L><I><A><T><V><W><T><L><G><F><A><I><C><S><P><L><P><V><F><H><S><L><V><E><L><Q><E><T><F><G><S><A><L><L><S><S><R><Y><L><C><V><E><S><W><P><S><D><S><Y><R><I><A><F><T><I><S><L><L><L><V><Q><Y><I><L><P><L><V><C><L><T><V><S><H><T><S><V><C><R><S><I><S><C><G><L><S><N><K><E><N><R><L><E><E><N><E><M><I><N><L><T><L><H><P><S><K><K><S><G><P><Q><V><K><L><S><G><S><H><K><W><S><Y><S><F><I><K><K><H><R><R><R><Y><S><K><K><T><A><C><V><L><P><A><P><E><R><P><S><Q><E><N><H><S><R><I><L><P><E><N><F><G><S><V><R><S><Q><L><S><S><S><S><K><F><I><P><G><V><P><T><C><F><E><I><K><P><E><E><N><S><D><V><H><E><L><R><V><K><R><S><V><T><R><I><K><K><R><S><R><S><V><F><Y><R><L><T><I><L><I><L><V><F><A><V><S><W><M><P><L><H><L><F><H><V><V><T><D><F><N><D><N><L><I><S><N><R><H><F><K><L><V><Y><C><I><C><H><L><L><G><M><M><S><C><C><L><N><P><I><L><Y><G><F><L><N><N><G><I><K><A><D><L><V><S><L><I><H><C><L><H><M>
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.<BOP>
Q15761
A8MUU1
FB5L3_HUMAN
Fatty acid-binding protein 5 pseudogene 3
Homo
<M><G><A><M><A><K><P><D><C><I><I><T><C><D><S><K><N><L><T><I><K><T><E><S><T><L><K><T><T><Q><F><S><G><T><L><G><E><K><F><E><E><N><T><A><D><G><R><R><T><Q><T><V><C><N><F><T><D><G><A><L><V><Q><H><Q><E><W><D><G><K><E><S><T><I><T><R><K><L><K><D><G><K><L><V><V><E><R><V><M><N><H><V><A><C><T><R><I><Y><E><K><A><Q>
High specificity for fatty acids.<BOP>
A8MUU1
Q96B01
R51A1_HUMAN
RAD51-interacting protein
Homo
<M><V><R><P><V><R><H><K><K><P><V><N><Y><S><Q><F><D><H><S><D><S><D><D><D><F><V><S><A><T><V><P><L><N><K><K><S><R><T><A><P><K><E><L><K><Q><D><K><P><K><P><N><L><N><N><L><R><K><E><E><I><P><V><Q><E><K><T><P><K><K><R><L><P><E><G><T><F><S><I><P><A><S><A><V><P><C><T><K><M><A><L><D><D><K><L><Y><Q><R><D><L><E><V><A><L><A><L><S><V><K><E><L><P><T><V><T><T><N><V><Q><N><S><Q><D><K><S><I><E><K><H><G><S><S><K><I><E><T><M><N><K><S><P><H><I><S><N><C><S><V><A><S><D><Y><L><D><L><D><K><I><T><V><E><D><D><V><G><G><V><Q><G><K><R><K><A><A><S><K><A><A><A><Q><Q><R><K><I><L><L><E><G><S><D><G><D><S><A><N><D><T><E><P><D><F><A><P><G><E><D><S><E><D><D><S><D><F><C><E><S><E><D><N><D><E><D><F><S><M><R><K><S><K><V><K><E><I><K><K><K><E><V><K><V><K><S><P><V><E><K><K><E><K><K><S><K><S><K><C><N><A><L><V><T><S><V><D><S><A><P><A><A><V><K><S><E><S><Q><S><L><P><K><K><V><S><L><S><S><D><T><T><R><K><P><L><E><I><R><S><P><S><A><E><S><K><K><P><K><W><V><P><P><A><A><S><G><G><S><R><S><S><S><S><P><L><V><V><V><S><V><K><S><P><N><Q><S><L><R><L><G><L><S><R><L><A><R><V><K><P><L><H><P><N><A><T><S><T>
Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination . Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 . Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation . Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair . WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 . Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination . Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination . May also bind RNA
Q96B01
Q6IEG0
SNR48_HUMAN
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
Homo
<M><E><G><E><P><P><P><V><E><E><R><R><R><L><Q><E><E><L><N><E><F><V><E><S><G><C><R><T><L><E><E><V><T><A><S><L><G><W><D><L><D><S><L><D><P><G><E><E><E><A><A><E><D><E><V><V><I><C><P><Y><D><S><N><H><H><M><P><K><S><S><L><A><K><H><M><A><S><C><R><L><R><K><M><G><Y><T><K><E><E><E><D><E><M><Y><N><P><E><F><F><Y><E><N><V><K><I><P><S><I><T><L><N><K><D><S><Q><F><Q><I><I><K><Q><A><R><T><A><V><G><K><D><S><D><C><Y><N><Q><R><I><Y><S><S><L><P><V><E><V><P><L><N><H><K><R><F><V><C><D><L><T><Q><A><D><R><L><A><L><Y><D><F><V><V><E><E><T><K><K><K><R><S><D><S><Q><I><I><E><N><D><S><D><L><F><V><D><L><A><A><K><I><N><Q><D><N><S><R><K><S><P><K><S><Y><L><E><I><L><A><E><V><R><D><Y><K><R><R><R><Q><S><Y><R><A><K><N><V><H><I><T><K><K><S><Y><T><E><V><I><R><D><V><I><N><V><H><M><E><E><L><S><N><H><W><Q><E><E><Q><E><K><A><E><D><D><A><E><K><N><E><E><R><R><S><A><S><V><D><S><R><Q><S><G><G><S><Y><L><D><A><E><C><S><R><H><R><R><D><R><S><R><S><P><H><K><R><K><R><N><K><D><K><D><K><N><C><E><S><R><R><R><K><E><R><D><G><E><R><H><H><S><H><K><R><R><K><Q><K><I>
Likely involved in U12-type 5' splice site recognition.<BOP>
Q6IEG0
Q6UW10
SFTA2_HUMAN
Surfactant-associated protein G
Homo
<M><G><S><G><L><P><L><V><L><L><L><T><L><L><G><S><S><H><G><T><G><P><G><M><T><L><Q><L><K><L><K><E><S><F><L><T><N><S><S><Y><E><S><S><F><L><E><L><L><E><K><L><C><L><L><L><H><L><P><S><G><T><S><V><T><L><H><H><A><R><S><Q><H><H><V><V><C><N><T>
Putative surfactant protein.<BOP>
Q6UW10
P20333
TNR1B_HUMAN
TBPII
Homo
<M><A><P><V><A><V><W><A><A><L><A><V><G><L><E><L><W><A><A><A><H><A><L><P><A><Q><V><A><F><T><P><Y><A><P><E><P><G><S><T><C><R><L><R><E><Y><Y><D><Q><T><A><Q><M><C><C><S><K><C><S><P><G><Q><H><A><K><V><F><C><T><K><T><S><D><T><V><C><D><S><C><E><D><S><T><Y><T><Q><L><W><N><W><V><P><E><C><L><S><C><G><S><R><C><S><S><D><Q><V><E><T><Q><A><C><T><R><E><Q><N><R><I><C><T><C><R><P><G><W><Y><C><A><L><S><K><Q><E><G><C><R><L><C><A><P><L><R><K><C><R><P><G><F><G><V><A><R><P><G><T><E><T><S><D><V><V><C><K><P><C><A><P><G><T><F><S><N><T><T><S><S><T><D><I><C><R><P><H><Q><I><C><N><V><V><A><I><P><G><N><A><S><M><D><A><V><C><T><S><T><S><P><T><R><S><M><A><P><G><A><V><H><L><P><Q><P><V><S><T><R><S><Q><H><T><Q><P><T><P><E><P><S><T><A><P><S><T><S><F><L><L><P><M><G><P><S><P><P><A><E><G><S><T><G><D><F><A><L><P><V><G><L><I><V><G><V><T><A><L><G><L><L><I><I><G><V><V><N><C><V><I><M><T><Q><V><K><K><K><P><L><C><L><Q><R><E><A><K><V><P><H><L><P><A><D><K><A><R><G><T><Q><G><P><E><Q><Q><H><L><L><I><T><A><P><S><S><S><S><S><S><L><E><S><S><A><S><A><L><D><R><R><A><P><T><R><N><Q><P><Q><A><P><G><V><E><A><S><G><A><G><E><A><R><A><S><T><G><S><S><D><S><S><P><G><G><H><G><T><Q><V><N><V><T><C><I><V><N><V><C><S><S><S><D><H><S><S><Q><C><S><S><Q><A><S><S><T><M><G><D><T><D><S><S><P><S><E><S><P><K><D><E><Q><V><P><F><S><K><E><E><C><A><F><R><S><Q><L><E><T><P><E><T><L><L><G><S><T><E><E><K><P><L><P><L><G><V><P><D><A><G><M><K><P><S>
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.<BOP>
P20333
Q13117
DAZ2_HUMAN
Deleted in azoospermia protein 2
Homo
<M><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K><L><K><L><G><P><A><I><R><K><Q><K><L><C><A><R><H><V><Q><P><R><P><L><V><V><N><P><P><P><P><P><Q><F><Q><N><V><W><R><N><P><N><T><E><T><Y><L><Q><P><Q><I><T><P><N><P><V><T><Q><H><V><Q><A><Y><S><A><Y><P><H><S><P><G><Q><V><I><T><G><C><Q><L><L><V><Y><N><Y><Q><E><Y><P><T><Y><P><D><S><A><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><P><F><P><A><Y><P><R><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><P><F><P><A><Y><P><S><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><A><V><Q><V><T><T><G><Y><Q><F><H><V><Y><N><Y><Q><M><P><P><Q><C><P><V><G><E><Q><R><R><N><L><W><T><E><A><Y><K><W><W><Y><L><V><C><L><I><Q><R><R><D>
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.<BOP>
Q13117
Q9Y2P7
ZN256_HUMAN
Bone marrow zinc finger 3
Homo
<M><A><A><A><E><L><T><A><P><A><Q><G><I><V><T><F><E><D><V><A><V><Y><F><S><W><K><E><W><G><L><L><D><E><A><Q><K><C><L><Y><H><D><V><M><L><E><N><L><T><L><T><T><S><L><G><G><S><G><A><G><D><E><E><A><P><Y><Q><Q><S><T><S><P><Q><R><V><S><Q><V><R><I><P><K><A><L><P><S><P><Q><K><T><N><P><C><E><I><C><G><P><V><L><R><Q><I><L><H><L><V><E><H><Q><G><T><H><H><G><Q><K><L><Y><T><D><G><A><C><R><K><Q><L><Q><F><T><A><Y><L><H><Q><H><Q><K><Q><H><V><G><Q><K><H><F><R><S><N><G><G><R><D><M><F><L><S><S><C><T><F><E><V><S><G><K><P><F><T><C><K><E><V><G><K><D><F><L><V><R><S><R><F><L><Q><Q><Q><A><A><H><T><R><K><K><S><N><R><T><K><S><A><V><A><F><H><S><V><K><N><H><Y><N><W><G><E><C><V><K><A><F><S><Y><K><H><V><R><V><Q><H><Q><G><D><L><I><R><E><R><S><Y><M><C><S><E><C><G><K><S><F><S><T><S><C><S><L><S><D><H><L><R><V><H><T><S><E><K><P><Y><T><C><G><E><C><G><K><S><Y><R><Q><S><S><S><L><I><T><H><R><R><I><H><T><G><V><R><P><H><Q><C><D><E><C><G><K><L><F><N><R><K><Y><D><L><L><I><H><Q><R><V><H><T><G><E><R><P><Y><K><C><S><E><C><G><K><S><F><S><H><S><S><S><L><I><T><H><Q><R><I><H><T><G><M><R><P><Y><E><C><S><E><C><G><K><S><F><I><H><S><S><S><L><I><T><H><Q><R><V><H><T><G><T><R><P><Y><M><C><S><E><C><G><K><S><F><S><Q><S><C><H><L><I><K><H><R><R><L><H><I><G><E><G><P><Y><E><C><S><E><C><G><K><L><F><T><Y><R><S><R><F><F><Q><H><Q><R><V><H><T><G><V><R><S><H><E><C><H><E><C><G><K><L><F><S><R><K><F><D><L><I><V><H><E><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><T><C><K><S><Y><L><I><S><H><W><K><V><H><T><G><A><R><P><Y><E><C><G><E><C><G><K><S><F><T><H><S><S><T><L><L><Q><H><Q><R><V><H><T><G><E><R><P><Y><E><C><N><E><C><G><K><F><F><S><Q><S><S><S><L><I><R><H><R><R><S><H><T><G><E><R><P><Y><E><C><S><E><C><W><K><S><F><S><N><H><S><S><L><V><K><H><R><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><Q><S><S><N><L><T><N><H><Q><R><I><H><S><G><E><R><P><Y><E><C><S><D><C><G><K><F><F><T><F><N><S><N><L><L><K><H><Q><N><V><H><K><G>
Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.<BOP>
Q9Y2P7
Q5T2E6
ARMD3_HUMAN
Armadillo-like helical domain-containing protein 3
Homo
<M><A><Q><V><E><K><R><G><G><L><L><R><K><S><S><A><S><K><K><P><L><K><E><K><V><V><L><M><Y><D><E><I><F><M><T><E><D><P><S><K><C><S><P><R><F><W><E><E><L><F><L><M><K><V><N><L><E><Y><L><E><G><K><L><E><S><L><D><G><E><E><L><M><K><I><K><D><N><I><N><C><L><F><Q><H><C><I><Q><A><L><G><E><E><H><P><I><R><V><V><N><A><L><Q><T><L><C><A><L><I><R><G><V><H><Q><K><N><K><S><T><S><G><F><D><I><I><N><M><L><M><G><F><D><K><A><E><L><C><M><K><N><L><M><E><S><L><D><S><L><L><C><A><E><G><S><E><S><L><K><S><L><C><L><K><L><L><L><C><L><V><T><V><T><D><N><I><S><Q><N><T><I><L><E><Y><V><M><I><N><S><I><F><E><A><I><L><Q><I><L><S><H><P><P><S><R><R><E><H><G><Y><D><A><V><V><L><L><A><L><L><V><N><Y><R><K><Y><E><S><V><N><P><Y><I><V><K><L><S><I><V><D><D><E><A><T><L><N><G><M><G><L><V><I><A><Q><A><L><S><E><Y><N><R><Q><Y><K><D><K><E><E><E><H><Q><S><G><F><F><S><A><L><T><N><M><V><G><S><M><F><I><A><D><A><H><E><K><I><S><V><Q><T><N><E><A><I><L><L><A><L><Y><E><A><V><H><L><N><R><N><F><I><T><V><L><A><Q><S><H><P><E><M><G><L><V><T><T><P><V><S><P><A><P><T><T><P><V><T><P><L><G><T><T><P><P><S><S><D><V><I><S><S><V><E><L><P><L><D><A><D><V><Q><T><S><N><L><L><I><T><F><L><K><Y><S><S><I><V><M><Q><D><T><K><D><E><H><R><L><H><S><G><K><L><C><L><I><I><L><T><C><I><A><E><D><Q><Y><A><N><A><F><L><H><D><D><N><M><N><F><R><V><N><L><H><R><M><P><M><R><H><R><K><K><A><A><D><K><N><L><P><C><R><P><L><V><C><A><V><L><D><L><M><V><E><F><I><V><T><H><M><M><K><E><F><P><M><D><L><Y><I><R><C><I><Q><V><V><H><K><L><L><C><Y><Q><K><K><C><R><V><R><L><H><Y><T><W><R><E><L><W><S><A><L><I><N><L><L><K><F><L><M><S><N><E><T><V><L><L><A><K><H><N><I><F><T><L><A><L><M><I><V><N><L><F><N><M><F><I><T><Y><G><D><T><F><L><P><T><P><S><S><Y><D><E><L><Y><Y><E><I><I><R><M><H><Q><S><F><D><N><L><Y><S><M><V><L><R><L><S><T><N><A><G><Q><W><K><E><A><A><S><K><V><T><H><A><L><V><N><I><R><A><I><I><N><H><F><N><P><K><I><E><S><Y><A><A><V><N><H><I><S><Q><L><S><E><E><Q><V><L><E><V><V><R><A><N><Y><D><T><L><T><L><K><L><Q><D><G><L><D><Q><Y><E><R><Y><S><E><Q><H><K><E><A><A><F><F><K><E><L><V><R><S><I><S><T><N><V><R><R><N><L><A><F><H><T><L><S><Q><E><V><L><L><K><E><F><S><T><I><S>
Involved in GBF1 recruitment, Golgi maintenance and protein secretion.<BOP>
Q5T2E6
O14990
IPP2C_HUMAN
Type-1 protein phosphatase inhibitor 4
Homo
<M><S><A><S><T><S><S><H><R><P><I><K><G><I><L><K><N><K><S><S><S><G><S><S><V><A><T><S><G><Q><Q><S><G><G><T><I><Q><D><V><K><R><K><K><S><Q><K><W><D><E><S><S><I><L><A><A><H><R><A><T><Y><R><D><Y><D><L><M><K><A><N><E><P><G><T><S><Y><M><S><V><Q><D><N><G><E><D><S><V><R><D><V><E><G><E><D><S><V><R><G><V><E><G><K><E><A><T><D><A><S><D><H><S><C><E><V><D><E><Q><E><S><S><E><A><Y><M><R><K><I><L><L><H><K><Q><E><K><K><R><Q><F><E><M><R><R><R><L><H><Y><N><E><E><L><N><I><K><L><A><R><Q><L><M><W><K><E><L><Q><S><E><D><N><E><N><E><E><T><P><Q><G><T><N><E><E><K><T><A><A><E><E><S><E><E><A><P><L><T><G><G><L><Q><T><Q><S><C><D><P>
Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.<BOP>
O14990
Q5EBM0
CMPK2_HUMAN
Nucleoside-diphosphate kinase
Homo
<M><A><F><A><R><R><L><L><R><G><P><L><S><G><P><L><L><G><R><R><G><V><C><A><G><A><M><A><P><P><R><R><F><V><L><E><L><P><D><C><T><L><A><H><F><A><L><G><A><D><A><P><G><D><A><D><A><P><D><P><R><L><A><A><L><L><G><P><P><E><R><S><Y><S><L><C><V><P><V><T><P><D><A><G><C><G><A><R><V><R><A><A><R><L><H><Q><R><L><L><H><Q><L><R><R><G><P><F><Q><R><C><Q><L><L><R><L><L><C><Y><C><P><G><G><Q><A><G><G><A><Q><Q><G><F><L><L><R><D><P><L><D><D><P><D><T><R><Q><A><L><L><E><L><L><G><A><C><Q><E><A><P><R><P><H><L><G><E><F><E><A><D><P><R><G><Q><L><W><Q><R><L><W><E><V><Q><D><G><R><R><L><Q><V><G><C><A><Q><V><V><P><V><P><E><P><P><L><H><P><V><V><P><D><L><P><S><S><V><V><F><P><D><R><E><A><A><R><A><V><L><E><E><C><T><S><F><I><P><E><A><R><A><V><L><D><L><V><D><Q><C><P><K><Q><I><Q><K><G><K><F><Q><V><V><A><I><E><G><L><D><A><T><G><K><T><T><V><T><Q><S><V><A><D><S><L><K><A><V><L><L><K><S><P><P><S><C><I><G><Q><W><R><K><I><F><D><D><E><P><T><I><I><R><R><A><F><Y><S><L><G><N><Y><I><V><A><S><E><I><A><K><E><S><A><K><S><P><V><I><V><D><R><Y><W><H><S><T><A><T><Y><A><I><A><T><E><V><S><G><G><L><Q><H><L><P><P><A><H><H><P><V><Y><Q><W><P><E><D><L><L><K><P><D><L><I><L><L><L><T><V><S><P><E><E><R><L><Q><R><L><Q><G><R><G><M><E><K><T><R><E><E><A><E><L><E><A><N><S><V><F><R><Q><K><V><E><M><S><Y><Q><R><M><E><N><P><G><C><H><V><V><D><A><S><P><S><R><E><K><V><L><Q><T><V><L><S><L><I><Q><N><S><F><S><E><P>
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.<BOP>
Q5EBM0
Q9NRE1
MMP26_HUMAN
Matrilysin-2
Homo
<M><Q><L><V><I><L><R><V><T><I><F><L><P><W><C><F><A><V><P><V><P><P><A><A><D><H><K><G><W><D><F><V><E><G><Y><F><H><Q><F><F><L><T><K><K><E><S><P><L><L><T><Q><E><T><Q><T><Q><L><L><Q><Q><F><H><R><N><G><T><D><L><L><D><M><Q><M><H><A><L><L><H><Q><P><H><C><G><V><P><D><G><S><D><T><S><I><S><P><G><R><C><K><W><N><K><H><T><L><T><Y><R><I><I><N><Y><P><H><D><M><K><P><S><A><V><K><D><S><I><Y><N><A><V><S><I><W><S><N><V><T><P><L><I><F><Q><Q><V><Q><N><G><D><A><D><I><K><V><S><F><W><Q><W><A><H><E><D><G><W><P><F><D><G><P><G><G><I><L><G><H><A><F><L><P><N><S><G><N><P><G><V><V><H><F><D><K><N><E><H><W><S><A><S><D><T><G><Y><N><L><F><L><V><A><T><H><E><I><G><H><S><L><G><L><Q><H><S><G><N><Q><S><S><I><M><Y><P><T><Y><W><Y><H><D><P><R><T><F><Q><L><S><A><D><D><I><Q><R><I><Q><H><L><Y><G><E><K><C><S><S><D><I><P>
May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.<BOP>
Q9NRE1
Q86W34
AMZ2_HUMAN
Archeobacterial metalloproteinase-like protein 2
Homo
<M><Q><I><I><R><H><S><E><Q><T><L><K><T><A><L><I><S><K><N><P><V><L><V><S><Q><Y><E><K><L><N><A><G><E><Q><R><L><M><N><E><A><F><Q><P><A><S><D><L><F><G><P><I><T><L><H><S><P><S><D><W><I><T><S><H><P><E><A><P><Q><D><F><E><Q><F><F><S><D><P><Y><R><K><T><P><S><P><N><K><R><S><I><Y><I><Q><S><I><G><S><L><G><N><T><R><I><I><S><E><E><Y><I><K><W><L><T><G><Y><C><K><A><Y><F><Y><G><L><R><V><K><L><L><E><P><V><P><V><S><V><T><R><C><S><F><R><V><N><E><N><T><H><N><L><Q><I><H><A><G><D><I><L><K><F><L><K><K><K><K><P><E><D><A><F><C><V><V><G><I><T><M><I><D><L><Y><P><R><D><S><W><N><F><V><F><G><Q><A><S><L><T><D><G><V><G><I><F><S><F><A><R><Y><G><S><D><F><Y><S><M><H><Y><K><G><K><V><K><K><L><K><K><T><S><S><S><D><Y><S><I><F><D><N><Y><Y><I><P><E><I><T><S><V><L><L><L><R><S><C><K><T><L><T><H><E><I><G><H><I><F><G><L><R><H><C><Q><W><L><A><C><L><M><Q><G><S><N><H><L><E><E><A><D><R><R><P><L><N><L><C><P><I><C><L><H><K><L><Q><C><A><V><G><F><S><I><V><E><R><Y><K><A><L><V><R><W><I><D><D><E><S><S><D><T><P><G><A><T><P><E><H><S><H><E><D><N><G><N><L><P><K><P><V><E><A><F><K><E><W><K><E><W><I><I><K><C><L><A><V><L><Q><K>
Probable zinc metalloprotease.<BOP>
Q86W34
Q6NXT1
ANR54_HUMAN
Lyn-interacting ankyrin repeat protein
Homo
<M><A><A><A><A><G><D><A><D><D><E><P><R><S><G><H><S><S><S><E><G><E><C><A><V><A><P><E><P><L><T><D><A><E><G><L><F><S><F><A><D><F><G><S><A><L><G><G><G><G><A><G><L><S><G><R><A><S><G><G><A><Q><S><P><L><R><Y><L><H><V><L><W><Q><Q><D><A><E><P><R><D><E><L><R><C><K><I><P><A><G><R><L><R><R><A><A><R><P><H><R><R><L><G><P><T><G><K><E><V><H><A><L><K><R><L><R><D><S><A><N><A><N><D><V><E><T><V><Q><Q><L><L><E><D><G><A><D><P><C><A><A><D><D><K><G><R><T><A><L><H><F><A><S><C><N><G><N><D><Q><I><V><Q><L><L><L><D><H><G><A><D><P><N><Q><R><D><G><L><G><N><T><P><L><H><L><A><A><C><T><N><H><V><P><V><I><T><T><L><L><R><G><G><A><R><V><D><A><L><D><R><A><G><R><T><P><L><H><L><A><K><S><K><L><N><I><L><Q><E><G><H><A><Q><C><L><E><A><V><R><L><E><V><K><Q><I><I><H><M><L><R><E><Y><L><E><R><L><G><Q><H><E><Q><R><E><R><L><D><D><L><C><T><R><L><Q><M><T><S><T><K><E><Q><V><D><E><V><T><D><L><L><A><S><F><T><S><L><S><L><Q><M><Q><S><M><E><K><R>
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.<BOP>
Q6NXT1
P05109
S10A8_HUMAN
Urinary stone protein band A
Homo
<M><L><T><E><L><E><K><A><L><N><S><I><I><D><V><Y><H><K><Y><S><L><I><K><G><N><F><H><A><V><Y><R><D><D><L><K><K><L><L><E><T><E><C><P><Q><Y><I><R><K><K><G><A><D><V><W><F><K><E><L><D><I><N><T><D><G><A><V><N><F><Q><E><F><L><I><L><V><I><K><M><G><V><A><A><H><K><K><S><H><E><E><S><H><K><E>
(Microbial infection) Upon infection by human coronavirus SARS-CoV-2, may induce expansion of aberrant immature neutrophils in a TLR4-dependent manner.<BOP>
P05109
P02655
APOC2_HUMAN
Proapolipoprotein C-II
Homo
<M><G><T><R><L><L><P><A><L><F><L><V><L><L><V><L><G><F><E><V><Q><G><T><Q><Q><P><Q><Q><D><E><M><P><S><P><T><F><L><T><Q><V><K><E><S><L><S><S><Y><W><E><S><A><K><T><A><A><Q><N><L><Y><E><K><T><Y><L><P><A><V><D><E><K><L><R><D><L><Y><S><K><S><T><A><A><M><S><T><Y><T><G><I><F><T><D><Q><V><L><S><V><L><K><G><E><E>
Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.<BOP>
P02655
P37173
TGFR2_HUMAN
Transforming growth factor-beta receptor type II
Homo
<M><G><R><G><L><L><R><G><L><W><P><L><H><I><V><L><W><T><R><I><A><S><T><I><P><P><H><V><Q><K><S><V><N><N><D><M><I><V><T><D><N><N><G><A><V><K><F><P><Q><L><C><K><F><C><D><V><R><F><S><T><C><D><N><Q><K><S><C><M><S><N><C><S><I><T><S><I><C><E><K><P><Q><E><V><C><V><A><V><W><R><K><N><D><E><N><I><T><L><E><T><V><C><H><D><P><K><L><P><Y><H><D><F><I><L><E><D><A><A><S><P><K><C><I><M><K><E><K><K><K><P><G><E><T><F><F><M><C><S><C><S><S><D><E><C><N><D><N><I><I><F><S><E><E><Y><N><T><S><N><P><D><L><L><L><V><I><F><Q><V><T><G><I><S><L><L><P><P><L><G><V><A><I><S><V><I><I><I><F><Y><C><Y><R><V><N><R><Q><Q><K><L><S><S><T><W><E><T><G><K><T><R><K><L><M><E><F><S><E><H><C><A><I><I><L><E><D><D><R><S><D><I><S><S><T><C><A><N><N><I><N><H><N><T><E><L><L><P><I><E><L><D><T><L><V><G><K><G><R><F><A><E><V><Y><K><A><K><L><K><Q><N><T><S><E><Q><F><E><T><V><A><V><K><I><F><P><Y><E><E><Y><A><S><W><K><T><E><K><D><I><F><S><D><I><N><L><K><H><E><N><I><L><Q><F><L><T><A><E><E><R><K><T><E><L><G><K><Q><Y><W><L><I><T><A><F><H><A><K><G><N><L><Q><E><Y><L><T><R><H><V><I><S><W><E><D><L><R><K><L><G><S><S><L><A><R><G><I><A><H><L><H><S><D><H><T><P><C><G><R><P><K><M><P><I><V><H><R><D><L><K><S><S><N><I><L><V><K><N><D><L><T><C><C><L><C><D><F><G><L><S><L><R><L><D><P><T><L><S><V><D><D><L><A><N><S><G><Q><V><G><T><A><R><Y><M><A><P><E><V><L><E><S><R><M><N><L><E><N><V><E><S><F><K><Q><T><D><V><Y><S><M><A><L><V><L><W><E><M><T><S><R><C><N><A><V><G><E><V><K><D><Y><E><P><P><F><G><S><K><V><R><E><H><P><C><V><E><S><M><K><D><N><V><L><R><D><R><G><R><P><E><I><P><S><F><W><L><N><H><Q><G><I><Q><M><V><C><E><T><L><T><E><C><W><D><H><D><P><E><A><R><L><T><A><Q><C><V><A><E><R><F><S><E><L><E><H><L><D><R><L><S><G><R><S><C><S><E><E><K><I><P><E><D><G><S><L><N><T><T><K>
Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.<BOP>
P37173
P41208
CETN2_HUMAN
Caltractin isoform 1
Homo
<M><A><S><N><F><K><K><A><N><M><A><S><S><S><Q><R><K><R><M><S><P><K><P><E><L><T><E><E><Q><K><Q><E><I><R><E><A><F><D><L><F><D><A><D><G><T><G><T><I><D><V><K><E><L><K><V><A><M><R><A><L><G><F><E><P><K><K><E><E><I><K><K><M><I><S><E><I><D><K><E><G><T><G><K><M><N><F><G><D><F><L><T><V><M><T><Q><K><M><S><E><K><D><T><K><E><E><I><L><K><A><F><K><L><F><D><D><D><E><T><G><K><I><S><F><K><N><L><K><R><V><A><K><E><L><G><E><N><L><T><D><E><E><L><Q><E><M><I><D><E><A><D><R><D><G><D><G><E><V><S><E><Q><E><F><L><R><I><M><K><K><T><S><L><Y>
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.<BOP>
P41208
Q96AH8
RAB7B_HUMAN
Ras-related protein Rab-7b
Homo
<M><N><P><R><K><K><V><D><L><K><L><I><I><V><G><A><I><G><V><G><K><T><S><L><L><H><Q><Y><V><H><K><T><F><Y><E><E><Y><Q><T><T><L><G><A><S><I><L><S><K><I><I><I><L><G><D><T><T><L><K><L><Q><I><W><D><T><G><G><Q><E><R><F><R><S><M><V><S><T><F><Y><K><G><S><D><G><C><I><L><A><F><D><V><T><D><L><E><S><F><E><A><L><D><I><W><R><G><D><V><L><A><K><I><V><P><M><E><Q><S><Y><P><M><V><L><L><G><N><K><I><D><L><A><D><R><K><V><P><Q><E><V><A><Q><G><W><C><R><E><K><D><I><P><Y><F><E><V><S><A><K><N><D><I><N><V><V><Q><A><F><E><M><L><A><S><R><A><L><S><R><Y><Q><S><I><L><E><N><H><L><T><E><S><I><K><L><S><P><D><Q><S><R><S><R><C><C>
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.<BOP>
Q96AH8
Q5M9Q1
NKAPL_HUMAN
NKAP-like protein
Homo
<M><P><P><V><S><R><S><S><Y><S><E><D><I><V><G><S><R><R><R><R><R><S><S><S><G><S><P><P><S><P><Q><S><R><C><S><S><W><D><G><C><S><R><S><H><S><R><G><R><E><G><L><R><P><P><W><S><E><L><D><V><G><A><L><Y><P><F><S><R><S><G><S><R><G><R><L><P><R><F><R><N><Y><A><F><A><S><S><W><S><T><S><Y><S><G><Y><R><Y><H><R><H><C><Y><A><E><E><R><Q><S><A><E><D><Y><E><K><E><E><S><H><R><Q><R><R><L><K><E><R><E><R><I><G><E><L><G><A><P><E><V><W><G><P><S><P><K><F><P><Q><L><D><S><D><E><H><T><P><V><E><D><E><E><E><V><T><H><Q><K><S><S><S><S><D><S><N><S><E><E><H><R><K><K><K><T><S><R><S><R><N><K><K><K><R><K><N><K><S><S><K><R><K><H><R><K><Y><S><D><S><D><S><N><S><E><S><D><T><N><S><D><S><D><D><D><K><K><R><V><K><A><K><K><K><K><K><K><K><K><H><K><T><K><K><K><K><N><K><K><T><K><K><E><S><S><D><S><S><C><K><D><S><E><E><D><L><S><E><A><T><W><M><E><Q><P><N><V><A><D><T><M><D><L><I><G><P><E><A><P><I><I><H><T><S><Q><D><E><K><P><L><K><Y><G><H><A><L><L><P><G><E><G><A><A><M><A><E><Y><V><K><A><G><K><R><I><P><R><R><G><E><I><G><L><T><S><E><E><I><G><S><F><E><C><S><G><Y><V><M><S><G><S><R><H><R><R><M><E><A><V><R><L><R><K><E><N><Q><I><Y><S><A><D><E><K><R><A><L><A><S><F><N><Q><E><E><R><R><K><R><E><S><K><I><L><A><S><F><R><E><M><V><H><K><K><T><K><E><K><D><D><K>
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.<BOP>
Q5M9Q1
Q9H900
ZWILC_HUMAN
Protein zwilch homolog
Homo
<M><W><E><R><L><N><C><A><A><E><D><F><Y><S><R><L><L><Q><K><F><N><E><E><K><K><G><I><R><K><D><P><F><L><Y><E><A><D><V><Q><V><Q><L><I><S><K><G><Q><P><N><P><L><K><N><I><L><N><E><N><D><I><V><F><I><V><E><K><V><P><L><E><K><E><E><T><S><H><I><E><E><L><Q><S><E><E><T><A><I><S><D><F><S><T><G><E><N><V><G><P><L><A><L><P><V><G><K><A><R><Q><L><I><G><L><Y><T><M><A><H><N><P><N><M><T><H><L><K><I><N><L><P><V><T><A><L><P><P><L><W><V><R><C><D><S><S><D><P><E><G><T><C><W><L><G><A><E><L><I><T><T><N><N><S><I><T><G><I><V><L><Y><V><V><S><C><K><A><D><K><N><Y><S><V><N><L><E><N><L><K><N><L><H><K><K><R><H><H><L><S><T><V><T><S><K><G><F><A><Q><Y><E><L><F><K><S><S><A><L><D><D><T><I><T><A><S><Q><T><A><I><A><L><D><I><S><W><S><P><V><D><E><I><L><Q><I><P><P><L><S><S><T><A><T><L><N><I><K><V><E><S><G><E><P><R><G><P><L><N><H><L><Y><R><E><L><K><F><L><L><V><L><A><D><G><L><R><T><G><V><T><E><W><L><E><P><L><E><A><K><S><A><V><E><L><V><Q><E><F><L><N><D><L><N><K><L><D><G><F><G><D><S><T><K><K><D><T><E><V><E><T><L><K><H><D><T><A><A><V><D><R><S><V><K><R><L><F><K><V><R><S><D><L><D><F><A><E><Q><L><W><C><K><M><S><S><S><V><I><S><Y><Q><D><L><V><K><C><F><T><L><I><I><Q><S><L><Q><R><G><D><I><Q><P><W><L><H><S><G><S><N><S><L><L><S><K><L><I><H><Q><S><Y><H><G><T><M><D><T><V><S><L><S><G><T><I><P><V><Q><M><L><L><E><I><G><L><D><K><L><K><K><D><Y><I><S><F><F><I><G><Q><E><L><A><S><L><N><H><L><E><Y><F><I><A><P><S><V><D><I><Q><E><Q><V><Y><R><V><Q><K><L><H><H><I><L><E><I><L><V><S><C><M><P><F><I><K><S><Q><H><E><L><L><F><S><L><T><Q><I><C><I><K><Y><Y><K><Q><N><P><L><D><E><Q><H><I><F><Q><L><P><V><R><P><T><A><V><K><N><L><Y><Q><S><E><K><P><Q><K><W><R><V><E><I><Y><S><G><Q><K><K><I><K><T><V><W><Q><L><S><D><S><S><P><I><D><H><L><N><F><H><K><P><D><F><S><E><L><T><L><N><G><S><L><E><E><R><I><F><F><T><N><M><V><T><C><S><Q><V><H><F><K>
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex .<BOP>
Q9H900