accession
stringlengths 6
10
| name
stringlengths 8
11
| Full Name
stringlengths 2
102
⌀ | taxon
stringclasses 1
value | sequence
stringlengths 48
2.3k
| function
stringlengths 15
1.34k
| AlphaFoldDB
stringlengths 6
10
|
|---|---|---|---|---|---|---|
Q0ZGT2
|
NEXN_HUMAN
|
Nelin
|
Homo
|
<M><N><D><I><S><Q><K><A><E><I><L><L><S><S><S><K><P><V><P><K><T><Y><V><P><K><L><G><K><G><D><V><K><D><K><F><E><A><M><Q><R><A><R><E><E><R><N><Q><R><R><S><R><D><E><K><Q><R><R><K><E><Q><Y><I><R><E><R><E><W><N><R><R><K><Q><E><I><K><E><M><L><A><S><D><D><E><E><D><V><S><S><K><V><E><K><A><Y><V><P><K><L><T><G><T><V><K><G><R><F><A><E><M><E><K><Q><R><Q><E><E><Q><R><K><R><T><E><E><E><R><K><R><R><I><E><Q><D><M><L><E><K><R><K><I><Q><R><E><L><A><K><R><A><E><Q><I><E><D><I><N><N><T><G><T><E><S><A><S><E><E><G><D><D><S><L><L><I><T><V><V><P><V><K><S><Y><K><T><S><G><K><M><K><K><N><F><E><D><L><E><K><E><R><E><E><K><E><R><I><K><Y><E><E><D><K><R><I><R><Y><E><E><Q><R><P><S><L><K><E><A><K><C><L><S><L><V><M><D><D><E><I><E><S><E><A><K><K><E><S><L><S><P><G><K><L><K><L><T><F><E><E><L><E><R><Q><R><Q><E><N><R><K><K><Q><A><E><E><E><A><R><K><R><L><E><E><E><K><R><A><F><E><E><A><R><R><Q><M><V><N><E><D><E><E><N><Q><D><T><A><K><I><F><K><G><Y><R><P><G><K><L><K><L><S><F><E><E><M><E><R><Q><R><R><E><D><E><K><R><K><A><E><E><E><A><R><R><R><I><E><E><E><K><K><A><F><A><E><A><R><R><N><M><V><V><D><D><D><S><P><E><M><Y><K><T><I><S><Q><E><F><L><T><P><G><K><L><E><I><N><F><E><E><L><L><K><Q><K><M><E><E><E><K><R><R><T><E><E><E><R><K><H><K><L><E><M><E><K><Q><E><F><E><Q><L><R><Q><E><M><G><E><E><E><E><E><N><E><T><F><G><L><S><R><E><Y><E><E><L><I><K><L><K><R><S><G><S><I><Q><A><K><N><L><K><S><K><F><E><K><I><G><Q><L><S><E><K><E><I><Q><K><K><I><E><E><E><R><A><R><R><R><A><I><D><L><E><I><K><E><R><E><A><E><N><F><H><E><E><D><D><V><D><V><R><P><A><R><K><S><E><A><P><F><T><H><K><V><N><M><K><A><R><F><E><Q><M><A><K><A><R><E><E><E><E><Q><R><R><I><E><E><Q><K><L><L><R><M><Q><F><E><Q><R><E><I><D><A><A><L><Q><K><K><R><E><E><E><E><E><E><E><G><S><I><M><N><G><S><T><A><E><D><E><E><Q><T><R><S><G><A><P><W><F><K><K><P><L><K><N><T><S><V><V><D><S><E><P><V><R><F><T><V><K><V><T><G><E><P><K><P><E><I><T><W><W><F><E><G><E><I><L><Q><D><G><E><D><Y><Q><Y><I><E><R><G><E><T><Y><C><L><Y><L><P><E><T><F><P><E><D><G><G><E><Y><M><C><K><A><V><N><N><K><G><S><A><A><S><T><C><I><L><T><I><E><S><K><N>
|
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.<BOP>
|
Q0ZGT2
|
Q8IU60
|
DCP2_HUMAN
|
mRNA-decapping enzyme 2
|
Homo
|
<M><E><T><K><R><V><E><I><P><G><S><V><L><D><D><L><C><S><R><F><I><L><H><I><P><S><E><E><R><D><N><A><I><R><V><C><F><Q><I><E><L><A><H><W><F><Y><L><D><F><Y><M><Q><N><T><P><G><L><P><Q><C><G><I><R><D><F><A><K><A><V><F><S><H><C><P><F><L><L><P><Q><G><E><D><V><E><K><V><L><D><E><W><K><E><Y><K><M><G><V><P><T><Y><G><A><I><I><L><D><E><T><L><E><N><V><L><L><V><Q><G><Y><L><A><K><S><G><W><G><F><P><K><G><K><V><N><K><E><E><A><P><H><D><C><A><A><R><E><V><F><E><E><T><G><F><D><I><K><D><Y><I><C><K><D><D><Y><I><E><L><R><I><N><D><Q><L><A><R><L><Y><I><I><P><G><I><P><K><D><T><K><F><N><P><K><T><R><R><E><I><R><N><I><E><W><F><S><I><E><K><L><P><C><H><R><N><D><M><T><P><K><S><K><L><G><L><A><P><N><K><F><F><M><A><I><P><F><I><R><P><L><R><D><W><L><S><R><R><F><G><D><S><S><D><S><D><N><G><F><S><S><T><G><S><T><P><A><K><P><T><V><E><K><L><S><R><T><K><F><R><H><S><Q><Q><L><F><P><D><G><S><P><G><D><Q><W><V><K><H><R><Q><P><L><Q><Q><K><P><Y><N><N><H><S><E><M><S><D><L><L><K><G><K><N><Q><S><M><R><G><N><G><R><K><Q><Y><Q><D><S><P><N><Q><K><K><R><T><N><G><L><Q><P><A><K><Q><Q><N><S><L><M><K><C><E><K><K><L><H><P><R><K><L><Q><D><N><F><E><T><D><A><V><Y><D><L><P><S><S><S><E><D><Q><L><L><E><H><A><E><G><Q><P><V><A><C><N><G><H><C><K><F><P><F><S><S><R><A><F><L><S><F><K><F><D><H><N><A><I><M><K><I><L><D><L>
|
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Plays a role in replication-dependent histone mRNA degradation . Has higher activity towards mRNAs that lack a poly(A) tail . Has no activity towards a cap structure lacking an RNA moiety . The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts .<BOP>
|
Q8IU60
|
Q03692
|
COAA1_HUMAN
|
Collagen alpha-1(X) chain
|
Homo
|
<M><L><P><Q><I><P><F><L><L><L><V><S><L><N><L><V><H><G><V><F><Y><A><E><R><Y><Q><M><P><T><G><I><K><G><P><L><P><N><T><K><T><Q><F><F><I><P><Y><T><I><K><S><K><G><I><A><V><R><G><E><Q><G><T><P><G><P><P><G><P><A><G><P><R><G><H><P><G><P><S><G><P><P><G><K><P><G><Y><G><S><P><G><L><Q><G><E><P><G><L><P><G><P><P><G><P><S><A><V><G><K><P><G><V><P><G><L><P><G><K><P><G><E><R><G><P><Y><G><P><K><G><D><V><G><P><A><G><L><P><G><P><R><G><P><P><G><P><P><G><I><P><G><P><A><G><I><S><V><P><G><K><P><G><Q><Q><G><P><T><G><A><P><G><P><R><G><F><P><G><E><K><G><A><P><G><V><P><G><M><N><G><Q><K><G><E><M><G><Y><G><A><P><G><R><P><G><E><R><G><L><P><G><P><Q><G><P><T><G><P><S><G><P><P><G><V><G><K><R><G><E><N><G><V><P><G><Q><P><G><I><K><G><D><R><G><F><P><G><E><M><G><P><I><G><P><P><G><P><Q><G><P><P><G><E><R><G><P><E><G><I><G><K><P><G><A><A><G><A><P><G><Q><P><G><I><P><G><T><K><G><L><P><G><A><P><G><I><A><G><P><P><G><P><P><G><F><G><K><P><G><L><P><G><L><K><G><E><R><G><P><A><G><L><P><G><G><P><G><A><K><G><E><Q><G><P><A><G><L><P><G><K><P><G><L><T><G><P><P><G><N><M><G><P><Q><G><P><K><G><I><P><G><S><H><G><L><P><G><P><K><G><E><T><G><P><A><G><P><A><G><Y><P><G><A><K><G><E><R><G><S><P><G><S><D><G><K><P><G><Y><P><G><K><P><G><L><D><G><P><K><G><N><P><G><L><P><G><P><K><G><D><P><G><V><G><G><P><P><G><L><P><G><P><V><G><P><A><G><A><K><G><M><P><G><H><N><G><E><A><G><P><R><G><A><P><G><I><P><G><T><R><G><P><I><G><P><P><G><I><P><G><F><P><G><S><K><G><D><P><G><S><P><G><P><P><G><P><A><G><I><A><T><K><G><L><N><G><P><T><G><P><P><G><P><P><G><P><R><G><H><S><G><E><P><G><L><P><G><P><P><G><P><P><G><P><P><G><Q><A><V><M><P><E><G><F><I><K><A><G><Q><R><P><S><L><S><G><T><P><L><V><S><A><N><Q><G><V><T><G><M><P><V><S><A><F><T><V><I><L><S><K><A><Y><P><A><I><G><T><P><I><P><F><D><K><I><L><Y><N><R><Q><Q><H><Y><D><P><R><T><G><I><F><T><C><Q><I><P><G><I><Y><Y><F><S><Y><H><V><H><V><K><G><T><H><V><W><V><G><L><Y><K><N><G><T><P><V><M><Y><T><Y><D><E><Y><T><K><G><Y><L><D><Q><A><S><G><S><A><I><I><D><L><T><E><N><D><Q><V><W><L><Q><L><P><N><A><E><S><N><G><L><Y><S><S><E><Y><V><H><S><S><F><S><G><F><L><V><A><P><M>
|
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.<BOP>
|
Q03692
|
P17017
|
ZNF14_HUMAN
|
Zinc finger protein KOX6
|
Homo
|
<M><D><S><V><S><F><E><D><V><A><V><N><F><T><L><E><E><W><A><L><L><D><S><S><Q><K><K><L><Y><E><D><V><M><Q><E><T><F><K><N><L><V><C><L><G><K><K><W><E><D><Q><D><I><E><D><D><H><R><N><Q><G><K><N><R><R><C><H><M><V><E><R><L><C><E><S><R><R><G><S><K><C><G><E><T><T><S><Q><M><P><N><V><N><I><N><K><E><T><F><T><G><A><K><P><H><E><C><S><F><C><G><R><D><F><I><H><H><S><S><L><N><R><H><M><R><S><H><T><G><Q><K><P><N><E><Y><Q><E><Y><E><K><Q><P><C><K><C><K><A><V><G><K><T><F><S><Y><H><H><C><F><R><K><H><E><R><T><H><T><G><V><K><P><Y><E><C><K><Q><C><G><K><A><F><I><Y><Y><Q><P><F><Q><R><H><E><R><T><H><A><G><Q><K><P><Y><E><C><K><Q><C><G><K><T><F><I><Y><Y><Q><S><F><Q><K><H><A><H><T><G><K><K><P><Y><E><C><K><Q><C><G><K><A><F><I><C><Y><Q><S><F><Q><R><H><K><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><C><P><T><Y><F><R><T><H><E><R><T><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><S><F><L><S><S><F><R><R><H><K><R><T><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><F><Y><S><A><S><F><R><A><H><V><I><I><H><T><G><A><R><P><Y><K><C><K><E><C><G><K><A><F><N><S><S><N><S><C><R><V><H><E><R><T><H><I><G><E><K><P><Y><E><C><K><R><C><G><K><S><F><S><W><S><I><S><L><R><L><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><H><K><T><F><S><F><S><S><S><L><R><E><H><E><T><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><T><F><S><F><S><S><S><L><Q><R><H><E><R><T><H><N><A><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><C><S><S><Y><F><R><I><H><E><R><S><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><V><F><I><R><S><S><S><F><R><L><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><L><C><G><K><T><F><S><F><S><S><S><L><R><E><H><E><K><I><H><T><G><N><K><P><F><E><C><K><Q><C><G><K><A><F><L><R><S><S><Q><I><R><L><H><E><R><T><H><T><G><E><K><P><Y><Q><C><K><Q><C><G><K><A><F><I><S><S><S><K><F><R><M><H><E><R><T><H><T><G><E><K><P><Y><R><C><K><Q><C><G><K><A><F><R><F><S><S><S><V><R><I><H><E><R><S><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><I><S><S><S><H><F><R><L><H><E><R><T><H><M><G><E><K><V>
|
May be involved in transcriptional regulation.<BOP>
|
P17017
|
P60509
|
ERB1_HUMAN
|
Transmembrane protein domain
|
Homo
|
<M><D><P><L><H><T><I><E><K><V><P><A><R><R><N><I><H><D><R><G><H><Q><G><H><R><M><G><D><G><T><P><G><R><P><K><I><S><V><Q><Q><M><T><R><F><S><L><I><I><F><F><L><S><A><P><F><V><V><N><A><S><T><S><N><V><F><L><Q><W><A><H><S><Y><A><D><G><L><Q><Q><G><D><P><C><W><V><C><G><S><L><P><V><T><N><T><M><E><L><P><W><W><V><S><P><L><Q><G><K><D><W><V><F><F><Q><S><F><I><G><D><L><K><Q><W><T><G><A><Q><M><T><G><V><T><R><K><N><I><S><E><W><P><I><N><K><T><L><N><E><P><G><H><D><K><P><F><S><V><N><E><T><R><D><K><V><I><A><F><A><I><P><L><L><D><T><K><V><F><V><Q><T><S><R><P><Q><N><T><Q><Y><R><N><G><F><L><Q><I><W><D><G><F><I><W><L><T><A><T><K><G><H><L><S><Q><I><A><P><L><C><W><E><Q><R><N><H><S><L><D><N><W><P><N><T><T><R><V><M><G><W><I><P><P><G><Q><C><R><H><T><I><L><L><Q><Q><R><D><L><F><A><T><D><W><S><Q><Q><P><G><L><N><W><Y><A><P><N><G><T><Q><W><L><C><S><P><N><L><W><P><W><L><P><S><G><W><L><G><C><C><T><L><G><I><P><W><A><Q><G><R><W><V><K><T><M><E><V><Y><P><Y><L><P><H><V><V><N><Q><G><T><R><A><I><V><H><R><N><D><H><L><P><T><I><F><M><P><S><V><G><L><G><T><V><I><Q><H><I><E><A><L><A><N><F><T><Q><R><A><L><N><D><S><L><Q><S><I><S><L><M><N><A><E><V><Y><Y><M><H><E><D><I><L><Q><N><R><M><A><L><D><I><L><T><A><A><E><G><G><T><C><A><L><I><K><T><E><C><C><V><Y><I><P><N><N><S><R><N><I><S><L><A><L><E><D><T><C><R><Q><I><Q><V><I><S><S><S><A><L><S><L><H><D><W><I><A><S><Q><F><S><G><R><P><S><W><W><Q><K><I><L><I><V><L><A><T><L><W><S><V><G><I><A><L><C><C><G><L><Y><F><C><R><M><F><S><Q><H><I><P><Q><T><H><S><I><I><F><Q><Q><E><L><P><L><S><P><P><S><Q><E><H><Y><Q><S><Q><R><D><I><F><H><S><N><A><P>
|
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.<BOP>
|
P60509
|
P35269
|
T2FA_HUMAN
|
Transcription initiation factor RAP74
|
Homo
|
<M><A><A><L><G><P><S><S><Q><N><V><T><E><Y><V><V><R><V><P><K><N><T><T><K><K><Y><N><I><M><A><F><N><A><A><D><K><V><N><F><A><T><W><N><Q><A><R><L><E><R><D><L><S><N><K><K><I><Y><Q><E><E><E><M><P><E><S><G><A><G><S><E><F><N><R><K><L><R><E><E><A><R><R><K><K><Y><G><I><V><L><K><E><F><R><P><E><D><Q><P><W><L><L><R><V><N><G><K><S><G><R><K><F><K><G><I><K><K><G><G><V><T><E><N><T><S><Y><Y><I><F><T><Q><C><P><D><G><A><F><E><A><F><P><V><H><N><W><Y><N><F><T><P><L><A><R><H><R><T><L><T><A><E><E><A><E><E><E><W><E><R><R><N><K><V><L><N><H><F><S><I><M><Q><Q><R><R><L><K><D><Q><D><Q><D><E><D><E><E><E><K><E><K><R><G><R><R><K><A><S><E><L><R><I><H><D><L><E><D><D><L><E><M><S><S><D><A><S><D><A><S><G><E><E><G><G><R><V><P><K><A><K><K><K><A><P><L><A><K><G><G><R><K><K><K><K><K><K><G><S><D><D><E><A><F><E><D><S><D><D><G><D><F><E><G><Q><E><V><D><Y><M><S><D><G><S><S><S><S><Q><E><E><P><E><S><K><A><K><A><P><Q><Q><E><E><G><P><K><G><V><D><E><Q><S><D><S><S><E><E><S><E><E><E><K><P><P><E><E><D><K><E><E><E><E><E><K><K><A><P><T><P><Q><E><K><K><R><R><K><D><S><S><E><E><S><D><S><S><E><E><S><D><I><D><S><E><A><S><S><A><L><F><M><A><K><K><K><T><P><P><K><R><E><R><K><P><S><G><G><S><S><R><G><N><S><R><P><G><T><P><S><A><E><G><G><S><T><S><S><T><L><R><A><A><A><S><K><L><E><Q><G><K><R><V><S><E><M><P><A><A><K><R><L><R><L><D><T><G><P><Q><S><L><S><G><K><S><T><P><Q><P><P><S><G><K><T><T><P><N><S><G><D><V><Q><V><T><E><D><A><V><R><R><Y><L><T><R><K><P><M><T><T><K><D><L><L><K><K><F><Q><T><K><K><T><G><L><S><S><E><Q><T><V><N><V><L><A><Q><I><L><K><R><L><N><P><E><R><K><M><I><N><D><K><M><H><F><S><L><K><E>
|
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.<BOP>
|
P35269
|
Q3MJ62
|
ZSC23_HUMAN
|
Zinc finger protein 453
|
Homo
|
<M><A><I><T><L><T><L><Q><T><A><E><M><Q><E><G><L><L><A><V><K><V><K><E><E><E><E><E><H><S><C><G><P><E><S><G><L><S><R><N><N><P><H><T><R><E><I><F><R><R><R><F><R><Q><F><C><Y><Q><E><S><P><G><P><R><E><A><L><Q><R><L><Q><E><L><C><H><Q><W><L><R><P><E><M><H><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><E><E><L><Q><A><W><V><R><Q><H><R><P><V><S><G><E><E><A><V><T><V><L><E><D><L><E><R><E><L><D><D><P><G><E><Q><V><L><S><H><A><H><E><Q><E><E><F><V><K><E><K><A><T><P><G><A><A><Q><E><S><S><N><D><Q><F><Q><T><L><E><E><Q><L><G><Y><N><L><R><E><V><C><P><V><Q><E><I><D><G><K><A><G><T><W><N><V><E><L><A><P><K><R><E><I><S><Q><E><V><K><S><L><I><Q><V><L><G><K><Q><N><G><N><I><T><Q><I><P><E><Y><G><D><T><C><D><R><E><G><R><L><E><K><Q><R><V><S><S><S><V><E><R><P><Y><I><C><S><E><C><G><K><S><F><T><Q><N><S><I><L><I><E><H><Q><R><T><H><T><G><E><K><P><Y><E><C><D><E><C><G><R><A><F><S><Q><R><S><G><L><F><Q><H><Q><R><L><H><T><G><E><K><R><Y><Q><C><S><V><C><G><K><A><F><S><Q><N><A><G><L><F><H><H><L><R><I><H><T><G><E><K><P><Y><Q><C><N><Q><C><N><K><S><F><S><R><R><S><V><L><I><K><H><Q><R><I><H><T><G><E><R><P><Y><E><C><E><E><C><G><K><N><F><I><Y><H><C><N><L><I><Q><H><R><K><V><H><P><V><A><E><S><S>
|
May be involved in transcriptional regulation.<BOP>
|
Q3MJ62
|
Q13360
|
ZN177_HUMAN
|
Zinc finger protein 177
|
Homo
|
<M><A><A><G><W><L><T><T><W><S><Q><N><S><V><T><F><Q><E><V><A><V><D><F><S><Q><E><E><W><A><L><L><D><P><A><Q><K><N><L><Y><K><D><V><M><L><E><N><F><R><N><L><A><S><V><G><Y><Q><L><C><R><H><S><L><I><S><K><V><D><Q><E><Q><L><K><T><D><E><R><G><I><L><Q><G><D><C><A><D><W><E><T><Q><L><K><P><K><D><T><I><A><M><Q><N><I><P><G><G><K><T><S><N><G><I><N><T><A><E><N><Q><P><G><E><H><S><L><E><C><N><H><C><G><K><F><R><K><N><T><R><F><I><C><T><R><Y><C><K><G><E><K><C><Y><K><Y><I><K><Y><S><K><V><F><N><H><P><S><T><L><R><S><H><V><S><I><H><I><G><E><K><T><L><E><F><T><D><C><R><K><A><F><N><Q><E><S><S><L><R><K><H><L><R><T><P><T><G><Q><K><F><Q><E><Y><E><Q><C><D><M><S><F><S><L><H><S><S><C><S><V><R><E><Q><I><P><T><G><E><K><G><D><E><C><S><D><Y><G><K><I><S><P><L><S><V><H><T><K><T><G><S><V><E><E><G><L><E><C><N><E><H><E><K><T><F><T><D><P><L><S><L><Q><N><C><V><R><T><H><S><G><E><M><P><Y><E><C><S><D><C><G><K><A><F><I><F><Q><S><S><L><K><K><H><M><R><S><H><T><G><E><K><P><Y><E><C><D><H><C><G><K><S><F><S><Q><S><S><H><L><N><V><H><K><R><T><H><T><G><E><K><P><Y><D><C><K><E><C><G><K><A><F><T><V><P><S><S><L><Q><K><H><V><R><T><H><T><G><E><K><P><Y><E><C><S><D><C><G><K><A><F><I><D><Q><S><S><L><K><K><H><T><R><S><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><S><F><S><T><G><S><Y><L><I><V><H><K><R><T><H><T><G><E><K><T><Y><E><C><K><E><C><G><K><A><F><R><N><S><S><C><L><R><V><H><V><R><T><H><T><G><E><K><P><Y><K><C><I><Q><C><E><K><A><F><S><T><S><T><N><L><I><M><H><K><R><I><H><N><G><Q><K><L><H><E>
|
May be involved in transcriptional regulation.<BOP>
|
Q13360
|
Q6P3S6
|
FBX42_HUMAN
|
Just one F-box and Kelch domain-containing protein
|
Homo
|
<M><A><S><S><S><D><S><E><D><D><S><F><M><A><V><D><Q><E><E><T><V><L><E><G><T><M><D><Q><D><E><E><P><H><P><V><L><E><A><E><E><T><R><H><N><R><S><M><S><E><L><P><E><E><V><L><E><Y><I><L><S><F><L><S><P><Y><Q><E><H><K><T><A><A><L><V><C><K><Q><W><Y><R><L><I><K><G><V><A><H><Q><C><Y><H><G><F><M><K><A><V><Q><E><G><N><I><Q><W><E><S><R><T><Y><P><Y><P><G><T><P><I><T><Q><R><F><S><H><S><A><C><Y><Y><D><A><N><Q><S><M><Y><V><F><G><G><C><T><Q><S><S><C><N><A><A><F><N><D><L><W><R><L><D><L><N><S><K><E><W><I><R><P><L><A><S><G><S><Y><P><S><P><K><A><G><A><T><L><V><V><Y><K><D><L><L><V><L><F><G><G><W><T><R><P><S><P><Y><P><L><H><Q><P><E><R><F><F><D><E><I><H><T><Y><S><P><S><K><N><W><W><N><C><I><V><T><T><H><G><P><P><P><M><A><G><H><S><S><C><V><I><D><D><K><M><I><V><F><G><G><S><L><G><S><R><Q><M><S><N><D><V><W><V><L><D><L><E><Q><W><A><W><S><K><P><N><I><S><G><P><S><P><H><P><R><G><G><Q><S><Q><I><V><I><D><D><A><T><I><L><I><L><G><G><C><G><G><P><N><A><L><F><K><D><A><W><L><L><H><M><H><S><G><P><W><A><W><Q><P><L><K><V><E><N><E><E><H><G><A><P><E><L><W><C><H><P><A><C><R><V><G><Q><C><V><V><V><F><S><Q><A><P><S><G><R><A><P><L><S><P><S><L><N><S><R><P><S><P><I><S><A><T><P><P><A><L><V><P><E><T><R><E><Y><R><S><Q><S><P><V><R><S><M><D><E><A><P><C><V><N><G><R><W><G><T><L><R><P><R><A><Q><R><Q><T><P><S><G><S><R><E><G><S><L><S><P><A><R><G><D><G><S><P><I><L><N><G><G><S><L><S><P><G><T><A><A><V><G><G><S><S><L><D><S><P><V><Q><A><I><S><P><S><T><P><S><A><P><E><G><Y><D><L><K><I><G><L><S><L><A><P><R><R><G><S><L><P><D><Q><K><D><L><R><L><G><S><I><D><L><N><W><D><L><K><P><A><S><S><S><N><P><M><D><G><M><D><N><R><T><V><G><G><S><M><R><H><P><P><E><Q><T><N><G><V><H><T><P><P><H><V><A><S><A><L><A><G><A><V><S><P><G><A><L><R><R><S><L><E><A><I><K><A><M><S><S><K><G><P><S><A><S><A><A><L><S><P><P><L><G><S><S><P><G><S><P><G><S><Q><S><L><S><S><G><E><T><V><P><I><P><R><P><G><P><A><Q><G><D><G><H><S><L><P><P><I><A><R><R><L><G><H><H><P><P><Q><S><L><N><V><G><K><P><L><Y><Q><S><M><N><C><K><P><M><Q><M><Y><V><L><D><I><K><D><T><K><E><K><G><R><V><K><W><K><V><F><N><S><S><S><V><V><G><P><P><E><T><S><L><H><T><V><V><Q><G><R><G><E><L><I><I><F><G><G><L><M><D><K><K><Q><N><V><K><Y><Y><P><K><T><N><A><L><Y><F><V><R><A><K><R>
|
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.<BOP>
|
Q6P3S6
|
Q9BT78
|
CSN4_HUMAN
|
JAB1-containing signalosome subunit 4
|
Homo
|
<M><A><A><A><V><R><Q><D><L><A><Q><L><M><N><S><S><G><S><H><K><D><L><A><G><K><Y><R><Q><I><L><E><K><A><I><Q><L><S><G><A><E><Q><L><E><A><L><K><A><F><V><E><A><M><V><N><E><N><V><S><L><V><I><S><R><Q><L><L><T><D><F><C><T><H><L><P><N><L><P><D><S><T><A><K><E><I><Y><H><F><T><L><E><K><I><Q><P><R><V><I><S><F><E><E><Q><V><A><S><I><R><Q><H><L><A><S><I><Y><E><K><E><E><D><W><R><N><A><A><Q><V><L><V><G><I><P><L><E><T><G><Q><K><Q><Y><N><V><D><Y><K><L><E><T><Y><L><K><I><A><R><L><Y><L><E><D><D><D><P><V><Q><A><E><A><Y><I><N><R><A><S><L><L><Q><N><E><S><T><N><E><Q><L><Q><I><H><Y><K><V><C><Y><A><R><V><L><D><Y><R><R><K><F><I><E><A><A><Q><R><Y><N><E><L><S><Y><K><T><I><V><H><E><S><E><R><L><E><A><L><K><H><A><L><H><C><T><I><L><A><S><A><G><Q><Q><R><S><R><M><L><A><T><L><F><K><D><E><R><C><Q><Q><L><A><A><Y><G><I><L><E><K><M><Y><L><D><R><I><I><R><G><N><Q><L><Q><E><F><A><A><M><L><M><P><H><Q><K><A><T><T><A><D><G><S><S><I><L><D><R><A><V><I><E><H><N><L><L><S><A><S><K><L><Y><N><N><I><T><F><E><E><L><G><A><L><L><E><I><P><A><A><K><A><E><K><I><A><S><Q><M><I><T><E><G><R><M><N><G><F><I><D><Q><I><D><G><I><V><H><F><E><T><R><E><A><L><P><T><W><D><K><Q><I><Q><S><L><C><F><Q><V><N><N><L><L><E><K><I><S><Q><T><A><P><E><W><T><A><Q><A><M><E><A><Q><M><A><Q>
|
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.<BOP>
|
Q9BT78
|
Q8NEW7
|
TMIE_HUMAN
|
Transmembrane inner ear expressed protein
|
Homo
|
<M><A><G><W><P><G><A><G><P><L><C><V><L><G><G><A><A><L><G><V><C><L><A><G><V><A><G><Q><L><V><E><P><S><T><A><P><P><K><P><K><P><P><P><L><T><K><E><T><V><V><F><W><D><M><R><L><W><H><V><V><G><I><F><S><L><F><V><L><S><I><I><I><T><L><C><C><V><F><N><C><R><V><P><R><T><R><K><E><I><E><A><R><Y><L><Q><R><K><A><A><K><M><Y><T><D><K><L><E><T><V><P><P><L><N><E><L><T><E><V><P><G><E><D><K><K><K><K><K><K><K><K><K><D><S><V><D><T><V><A><I><K><V><E><E><D><E><K><N><E><A><K><K><K><K><G><E><K>
|
Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.<BOP>
|
Q8NEW7
|
Q0D2I5
|
IFFO1_HUMAN
|
Tumor antigen HOM-TES-103
|
Homo
|
<M><N><P><L><F><G><P><N><L><F><L><L><Q><Q><E><Q><Q><G><L><A><G><P><L><G><D><S><L><G><G><D><H><F><A><G><G><G><D><L><P><P><A><P><L><S><P><A><G><P><A><A><Y><S><P><P><G><P><G><P><A><P><P><A><A><M><A><L><R><N><D><L><G><S><N><I><N><V><L><K><T><L><N><L><R><F><R><C><F><L><A><K><V><H><E><L><E><R><R><N><R><L><L><E><K><Q><L><Q><Q><A><L><E><E><G><K><Q><G><R><R><G><L><G><R><R><D><Q><A><V><Q><T><G><F><V><S><P><I><R><P><L><G><L><Q><L><G><A><R><P><A><A><V><C><S><P><S><A><R><V><L><G><S><P><A><R><S><P><A><G><P><L><A><P><S><A><A><S><L><S><S><S><S><T><S><T><S><T><T><Y><S><S><S><A><R><F><M><P><G><T><I><W><S><F><S><H><A><R><R><L><G><P><G><L><E><P><T><L><V><Q><G><P><G><L><S><W><V><H><P><D><G><V><G><V><Q><I><D><T><I><T><P><E><I><R><A><L><Y><N><V><L><A><K><V><K><R><E><R><D><E><Y><K><R><R><W><E><E><E><Y><T><V><R><I><Q><L><Q><D><R><V><N><E><L><Q><E><E><A><Q><E><A><D><A><C><Q><E><E><L><A><L><K><V><E><Q><L><K><A><E><L><V><V><F><K><G><L><M><S><N><N><L><S><E><L><D><T><K><I><Q><E><K><A><M><K><V><D><M><D><I><C><R><R><I><D><I><T><A><K><L><C><D><V><A><Q><Q><R><N><C><E><D><M><I><Q><M><F><Q><V><P><S><M><G><G><R><K><R><E><R><K><A><A><V><E><E><D><T><S><L><S><E><S><E><G><P><R><Q><P><D><G><D><E><E><E><S><T><A><L><S><I><N><E><E><M><Q><R><M><L><N><Q><L><R><E><Y><D><F><E><D><D><C><D><S><L><T><W><E><E><T><E><E><T><L><L><L><W><E><D><F><S><G><Y><A><M><A><A><A><E><A><Q><G><E><Q><E><D><S><L><E><K><V><I><K><D><T><E><S><L><F><K><T><R><E><K><E><Y><Q><E><T><I><D><Q><I><E><L><E><L><A><T><A><K><N><D><M><N><R><H><L><H><E><Y><M><E><M><C><S><M><K><R><G><L><D><V><Q><M><E><T><C><R><R><L><I><T><Q><S><G><D><R><K><S><P><A><F><T><A><V><P><L><S><D><P><P><P><P><P><S><E><A><E><D><S><D><R><D><V><S><S><D><S><S><M><R>
|
Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) . Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation . Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites .<BOP>
|
Q0D2I5
|
Q8WW33
|
GTSF1_HUMAN
|
Protein FAM112B
|
Homo
|
<M><E><E><T><Y><T><D><S><L><D><P><E><K><L><L><Q><C><P><Y><D><K><N><H><Q><I><R><A><C><R><F><P><Y><H><L><I><K><C><R><K><N><H><P><D><V><A><S><K><L><A><T><C><P><F><N><A><R><H><Q><V><P><R><A><E><I><S><H><H><I><S><S><C><D><D><R><S><C><I><E><Q><D><V><V><N><Q><T><R><S><L><R><Q><E><T><L><A><E><S><T><W><Q><C><P><P><C><D><E><D><W><D><K><D><L><W><E><Q><T><S><T><P><F><V><W><G><T><T><H><Y><S><D><N><N><S><P><A><S><N><I><V><T><E><H><K><N><N><L><A><S><G><M><R><V><P><K><S><L><P><Y><V><L><P><W><K><N><N><G><N><A><Q>
|
Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.<BOP>
|
Q8WW33
|
Q8N257
|
H2B3B_HUMAN
|
H2B.U histone 1
|
Homo
|
<M><P><D><P><S><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><G><R><K><E><S><Y><S><I><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><S><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><V><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K>
|
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
|
Q8N257
|
Q9GZW8
|
MS4A7_HUMAN
|
Four-span transmembrane protein 2
|
Homo
|
<M><L><L><Q><S><Q><T><M><G><V><S><H><S><F><T><P><K><G><I><T><I><P><Q><R><E><K><P><G><H><M><Y><Q><N><E><D><Y><L><Q><N><G><L><P><T><E><T><T><V><L><G><T><V><Q><I><L><C><C><L><L><I><S><S><L><G><A><I><L><V><F><A><P><Y><P><S><H><F><N><P><A><I><S><T><T><L><M><S><G><Y><P><F><L><G><A><L><C><F><G><I><T><G><S><L><S><I><I><S><G><K><Q><S><T><K><P><F><D><L><S><S><L><T><S><N><A><V><S><S><V><T><A><G><A><G><L><F><L><L><A><D><S><M><V><A><L><R><T><A><S><Q><H><C><G><S><E><M><D><Y><L><S><S><L><P><Y><S><E><Y><Y><Y><P><I><Y><E><I><K><D><C><L><L><T><S><V><S><L><T><G><V><L><V><V><M><L><I><F><T><V><L><E><L><L><L><A><A><Y><S><S><V><F><W><W><K><Q><L><Y><S><N><N><P><G><S><S><F><S><S><T><Q><S><Q><D><H><I><Q><Q><V><K><K><S><S><S><R><S><W><I>
|
May be involved in signal transduction as a component of a multimeric receptor complex.<BOP>
|
Q9GZW8
|
P20941
|
PHOS_HUMAN
|
Protein MEKA
|
Homo
|
<M><E><E><A><K><S><Q><S><L><E><E><D><F><E><G><Q><A><T><H><T><G><P><K><G><V><I><N><D><W><R><K><F><K><L><E><S><Q><D><S><D><S><I><P><P><S><K><K><E><I><L><R><Q><M><S><S><P><Q><S><R><N><G><K><D><S><K><E><R><V><S><R><K><M><S><I><Q><E><Y><E><L><I><H><K><E><K><E><D><E><N><C><L><R><K><Y><R><R><Q><C><M><Q><D><M><H><Q><K><L><S><F><G><P><R><Y><G><F><V><Y><E><L><E><T><G><K><Q><F><L><E><T><I><E><K><E><L><K><I><T><T><I><V><V><H><I><Y><E><D><G><I><K><G><C><D><A><L><N><S><S><L><T><C><L><A><A><E><Y><P><I><V><K><F><C><K><I><K><A><S><N><T><G><A><G><D><R><F><S><L><D><V><L><P><T><L><L><I><Y><K><G><G><E><L><I><S><N><F><I><S><V><A><E><Q><F><A><E><E><F><F><A><G><D><V><E><S><F><L><N><E><Y><G><L><L><P><E><R><E><V><H><V><L><E><H><T><K><I><E><E><E><D><V><E>
|
May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX.<BOP>
|
P20941
|
P21781
|
FGF7_HUMAN
|
Keratinocyte growth factor
|
Homo
|
<M><H><K><W><I><L><T><W><I><L><P><T><L><L><Y><R><S><C><F><H><I><I><C><L><V><G><T><I><S><L><A><C><N><D><M><T><P><E><Q><M><A><T><N><V><N><C><S><S><P><E><R><H><T><R><S><Y><D><Y><M><E><G><G><D><I><R><V><R><R><L><F><C><R><T><Q><W><Y><L><R><I><D><K><R><G><K><V><K><G><T><Q><E><M><K><N><N><Y><N><I><M><E><I><R><T><V><A><V><G><I><V><A><I><K><G><V><E><S><E><F><Y><L><A><M><N><K><E><G><K><L><Y><A><K><K><E><C><N><E><D><C><N><F><K><E><L><I><L><E><N><H><Y><N><T><Y><A><S><A><K><W><T><H><N><G><G><E><M><F><V><A><L><N><Q><K><G><I><P><V><R><G><K><K><T><K><K><E><Q><K><T><A><H><F><L><P><M><A><I><T>
|
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.<BOP>
|
P21781
|
Q9NUL7
|
DDX28_HUMAN
|
Mitochondrial DEAD box protein 28
|
Homo
|
<M><A><L><T><R><P><V><R><L><F><S><L><V><T><R><L><L><L><A><P><R><R><G><L><T><V><R><S><P><D><E><P><L><P><V><V><R><I><P><V><A><L><Q><R><Q><L><E><Q><R><Q><S><R><R><R><N><L><P><R><P><V><L><V><R><P><G><P><L><L><V><S><A><R><R><P><E><L><N><Q><P><A><R><L><T><L><G><R><W><E><R><A><P><L><A><S><Q><G><W><K><S><R><R><A><R><R><D><H><F><S><I><E><R><A><Q><Q><E><A><P><A><V><R><K><L><S><S><K><G><S><F><A><D><L><G><L><E><P><R><V><L><H><A><L><Q><E><A><A><P><E><V><V><Q><P><T><T><V><Q><S><S><T><I><P><S><L><L><R><G><R><H><V><V><C><A><A><E><T><G><S><G><K><T><L><S><Y><L><L><P><L><L><Q><R><L><L><G><Q><P><S><L><D><S><L><P><I><P><A><P><R><G><L><V><L><V><P><S><R><E><L><A><Q><Q><V><R><A><V><A><Q><P><L><G><R><S><L><G><L><L><V><R><D><L><E><G><G><H><G><M><R><R><I><R><L><Q><L><S><R><Q><P><S><A><D><V><L><V><A><T><P><G><A><L><W><K><A><L><K><S><R><L><I><S><L><E><Q><L><S><F><L><V><L><D><E><A><D><T><L><L><D><E><S><F><L><E><L><V><D><Y><I><L><E><K><S><H><I><A><E><G><P><A><D><L><E><D><P><F><N><P><K><A><Q><L><V><L><V><G><A><T><F><P><E><G><V><G><Q><L><L><N><K><V><A><S><P><D><A><V><T><T><I><T><S><S><K><L><H><C><I><M><P><H><V><K><Q><T><F><L><R><L><K><G><A><D><K><V><A><E><L><V><H><I><L><K><H><R><D><R><A><E><R><T><G><P><S><G><T><V><L><V><F><C><N><S><S><S><T><V><N><W><L><G><Y><I><L><D><D><H><K><I><Q><H><L><R><L><Q><G><Q><M><P><A><L><M><R><V><G><I><F><Q><S><F><Q><K><S><S><R><D><I><L><L><C><T><D><I><A><S><R><G><L><D><S><T><G><V><E><L><V><V><N><Y><D><F><P><P><T><L><Q><D><Y><I><H><R><A><G><R><V><G><R><V><G><S><E><V><P><G><T><V><I><S><F><V><T><H><P><W><D><V><S><L><V><Q><K><I><E><L><A><A><R><R><R><R><S><L><P><G><L><A><S><S><V><K><E><P><L><P><Q><A><T>
|
Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function . May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity .<BOP>
|
Q9NUL7
|
Q15928
|
ZN141_HUMAN
|
Zinc finger protein 141
|
Homo
|
<M><E><L><L><T><F><R><D><V><A><I><E><F><S><P><E><E><W><K><C><L><D><P><D><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><V><A><I><S><N><P><D><L><V><T><C><L><E><Q><R><K><E><P><Y><N><V><K><I><H><K><I><V><A><R><P><P><A><M><C><S><H><F><T><Q><D><H><W><P><V><Q><G><I><E><D><S><F><H><K><L><I><L><R><R><Y><E><K><C><G><H><D><N><L><Q><L><R><K><G><C><K><S><L><N><E><C><K><L><Q><K><G><G><Y><N><E><F><N><E><C><L><S><T><T><Q><S><K><I><L><Q><C><K><A><S><V><K><V><V><S><K><F><S><N><S><N><K><R><K><T><R><H><T><G><E><K><H><F><K><E><C><G><K><S><F><Q><K><F><S><H><L><T><Q><H><K><V><I><H><A><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><K><W><S><L><I><F><N><E><H><K><R><I><H><T><G><E><K><P><F><T><C><E><E><C><G><S><I><F><T><T><S><S><H><F><A><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><F><T><T><L><T><K><H><K><R><I><H><A><G><E><K><P><I><T><C><E><E><C><R><K><I><F><T><S><S><S><N><F><A><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><T><T><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><R><Q><S><S><K><L><N><E><H><K><K><V><H><T><G><E><R><P><Y><K><C><D><E><C><G><K><A><F><G><R><S><R><V><L><N><E><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><R><R><S><T><D><R><S><Q><H><K><K><I><H><S><A><D><K><P><Y><K><C><K><E><C><D><K><A><F><K><Q><F><S><L><L><S><Q><H><K><K><I><H><T><V><D><K><P><Y><K><C><K><D><C><D><K><A><F><K><R><F><S><H><L><N><K><H><K><K><I><H><T>
|
May be involved in transcriptional regulation as a repressor. Plays a role in limb development.<BOP>
|
Q15928
|
Q6L8H1
|
KRA54_HUMAN
|
Ultrahigh sulfur keratin-associated protein 5.4
|
Homo
|
<M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><G><Y><G><S><C><G><G><S><K><G><G><C><V><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><V><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><V><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><C><S><Q><C><S><C><C><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><Y><C><C><Q><S><S><C><C><K><P><C><C><S><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><N><P><C><C><S><Q><S><S><C><C><V><P><V><C><C><Q><C><K><I>
|
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
|
Q6L8H1
|
Q9UNE7
|
CHIP_HUMAN
|
STIP1 homology and U box-containing protein 1
|
Homo
|
<M><K><G><K><E><E><K><E><G><G><A><R><L><G><A><G><G><G><S><P><E><K><S><P><S><A><Q><E><L><K><E><Q><G><N><R><L><F><V><G><R><K><Y><P><E><A><A><A><C><Y><G><R><A><I><T><R><N><P><L><V><A><V><Y><Y><T><N><R><A><L><C><Y><L><K><M><Q><Q><H><E><Q><A><L><A><D><C><R><R><A><L><E><L><D><G><Q><S><V><K><A><H><F><F><L><G><Q><C><Q><L><E><M><E><S><Y><D><E><A><I><A><N><L><Q><R><A><Y><S><L><A><K><E><Q><R><L><N><F><G><D><D><I><P><S><A><L><R><I><A><K><K><K><R><W><N><S><I><E><E><R><R><I><H><Q><E><S><E><L><H><S><Y><L><S><R><L><I><A><A><E><R><E><R><E><L><E><E><C><Q><R><N><H><E><G><D><E><D><D><S><H><V><R><A><Q><Q><A><C><I><E><A><K><H><D><K><Y><M><A><D><M><D><E><L><F><S><Q><V><D><E><K><R><K><K><R><D><I><P><D><Y><L><C><G><K><I><S><F><E><L><M><R><E><P><C><I><T><P><S><G><I><T><Y><D><R><K><D><I><E><E><H><L><Q><R><V><G><H><F><D><P><V><T><R><S><P><L><T><Q><E><Q><L><I><P><N><L><A><M><K><E><V><I><D><A><F><I><S><E><N><G><W><V><E><D><Y>
|
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation . Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension . Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 . Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 . Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation . Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome . Mediates polyubiquitination of CYP3A4 . Ubiquitinates EPHA2 and may regulate
|
Q9UNE7
|
Q14116
|
IL18_HUMAN
|
Interleukin-1 gamma
|
Homo
|
<M><A><A><E><P><V><E><D><N><C><I><N><F><V><A><M><K><F><I><D><N><T><L><Y><F><I><A><E><D><D><E><N><L><E><S><D><Y><F><G><K><L><E><S><K><L><S><V><I><R><N><L><N><D><Q><V><L><F><I><D><Q><G><N><R><P><L><F><E><D><M><T><D><S><D><C><R><D><N><A><P><R><T><I><F><I><I><S><M><Y><K><D><S><Q><P><R><G><M><A><V><T><I><S><V><K><C><E><K><I><S><T><L><S><C><E><N><K><I><I><S><F><K><E><M><N><P><P><D><N><I><K><D><T><K><S><D><I><I><F><F><Q><R><S><V><P><G><H><D><N><K><M><Q><F><E><S><S><S><Y><E><G><Y><F><L><A><C><E><K><E><R><D><L><F><K><L><I><L><K><K><E><D><E><L><G><D><R><S><I><M><F><T><V><Q><N><E><D>
|
Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses . Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators . Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells . Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore .<BOP>
|
Q14116
|
P08172
|
ACM2_HUMAN
|
Muscarinic acetylcholine receptor M2
|
Homo
|
<M><N><N><S><T><N><S><S><N><N><S><L><A><L><T><S><P><Y><K><T><F><E><V><V><F><I><V><L><V><A><G><S><L><S><L><V><T><I><I><G><N><I><L><V><M><V><S><I><K><V><N><R><H><L><Q><T><V><N><N><Y><F><L><F><S><L><A><C><A><D><L><I><I><G><V><F><S><M><N><L><Y><T><L><Y><T><V><I><G><Y><W><P><L><G><P><V><V><C><D><L><W><L><A><L><D><Y><V><V><S><N><A><S><V><M><N><L><L><I><I><S><F><D><R><Y><F><C><V><T><K><P><L><T><Y><P><V><K><R><T><T><K><M><A><G><M><M><I><A><A><A><W><V><L><S><F><I><L><W><A><P><A><I><L><F><W><Q><F><I><V><G><V><R><T><V><E><D><G><E><C><Y><I><Q><F><F><S><N><A><A><V><T><F><G><T><A><I><A><A><F><Y><L><P><V><I><I><M><T><V><L><Y><W><H><I><S><R><A><S><K><S><R><I><K><K><D><K><K><E><P><V><A><N><Q><D><P><V><S><P><S><L><V><Q><G><R><I><V><K><P><N><N><N><N><M><P><S><S><D><D><G><L><E><H><N><K><I><Q><N><G><K><A><P><R><D><P><V><T><E><N><C><V><Q><G><E><E><K><E><S><S><N><D><S><T><S><V><S><A><V><A><S><N><M><R><D><D><E><I><T><Q><D><E><N><T><V><S><T><S><L><G><H><S><K><D><E><N><S><K><Q><T><C><I><R><I><G><T><K><T><P><K><S><D><S><C><T><P><T><N><T><T><V><E><V><V><G><S><S><G><Q><N><G><D><E><K><Q><N><I><V><A><R><K><I><V><K><M><T><K><Q><P><A><K><K><K><P><P><P><S><R><E><K><K><V><T><R><T><I><L><A><I><L><L><A><F><I><I><T><W><A><P><Y><N><V><M><V><L><I><N><T><F><C><A><P><C><I><P><N><T><V><W><T><I><G><Y><W><L><C><Y><I><N><S><T><I><N><P><A><C><Y><A><L><C><N><A><T><F><K><K><T><F><K><H><L><L><M><C><H><Y><K><N><I><G><A><T><R>
|
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.<BOP>
|
P08172
|
P34897
|
GLYM_HUMAN
|
Serine methylase
|
Homo
|
<M><L><Y><F><S><L><F><W><A><A><R><P><L><Q><R><C><G><Q><L><V><R><M><A><I><R><A><Q><H><S><N><A><A><Q><T><Q><T><G><E><A><N><R><G><W><T><G><Q><E><S><L><S><D><S><D><P><E><M><W><E><L><L><Q><R><E><K><D><R><Q><C><R><G><L><E><L><I><A><S><E><N><F><C><S><R><A><A><L><E><A><L><G><S><C><L><N><N><K><Y><S><E><G><Y><P><G><K><R><Y><Y><G><G><A><E><V><V><D><E><I><E><L><L><C><Q><R><R><A><L><E><A><F><D><L><D><P><A><Q><W><G><V><N><V><Q><P><Y><S><G><S><P><A><N><L><A><V><Y><T><A><L><L><Q><P><H><D><R><I><M><G><L><D><L><P><D><G><G><H><L><T><H><G><Y><M><S><D><V><K><R><I><S><A><T><S><I><F><F><E><S><M><P><Y><K><L><N><P><K><T><G><L><I><D><Y><N><Q><L><A><L><T><A><R><L><F><R><P><R><L><I><I><A><G><T><S><A><Y><A><R><L><I><D><Y><A><R><M><R><E><V><C><D><E><V><K><A><H><L><L><A><D><M><A><H><I><S><G><L><V><A><A><K><V><I><P><S><P><F><K><H><A><D><I><V><T><T><T><T><H><K><T><L><R><G><A><R><S><G><L><I><F><Y><R><K><G><V><K><A><V><D><P><K><T><G><R><E><I><P><Y><T><F><E><D><R><I><N><F><A><V><F><P><S><L><Q><G><G><P><H><N><H><A><I><A><A><V><A><V><A><L><K><Q><A><C><T><P><M><F><R><E><Y><S><L><Q><V><L><K><N><A><R><A><M><A><D><A><L><L><E><R><G><Y><S><L><V><S><G><G><T><D><N><H><L><V><L><V><D><L><R><P><K><G><L><D><G><A><R><A><E><R><V><L><E><L><V><S><I><T><A><N><K><N><T><C><P><G><D><R><S><A><I><T><P><G><G><L><R><L><G><A><P><A><L><T><S><R><Q><F><R><E><D><D><F><R><R><V><V><D><F><I><D><E><G><V><N><I><G><L><E><V><K><S><K><T><A><K><L><Q><D><F><K><S><F><L><L><K><D><S><E><T><S><Q><R><L><A><N><L><R><Q><R><V><E><Q><F><A><R><A><F><P><M><P><G><F><D><E><H>
|
Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis . Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate . Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA . Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs . Associates with mitochondrial DNA . In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex .<BOP>
|
P34897
|
O60258
|
FGF17_HUMAN
|
Fibroblast growth factor 17
|
Homo
|
<M><G><A><A><R><L><L><P><N><L><T><L><C><L><Q><L><L><I><L><C><C><Q><T><Q><G><E><N><H><P><S><P><N><F><N><Q><Y><V><R><D><Q><G><A><M><T><D><Q><L><S><R><R><Q><I><R><E><Y><Q><L><Y><S><R><T><S><G><K><H><V><Q><V><T><G><R><R><I><S><A><T><A><E><D><G><N><K><F><A><K><L><I><V><E><T><D><T><F><G><S><R><V><R><I><K><G><A><E><S><E><K><Y><I><C><M><N><K><R><G><K><L><I><G><K><P><S><G><K><S><K><D><C><V><F><T><E><I><V><L><E><N><N><Y><T><A><F><Q><N><A><R><H><E><G><W><F><M><A><F><T><R><Q><G><R><P><R><Q><A><S><R><S><R><Q><N><Q><R><E><A><H><F><I><K><R><L><Y><Q><G><Q><L><P><F><P><N><H><A><E><K><Q><K><Q><F><E><F><V><G><S><A><P><T><R><R><T><K><R><T><R><R><P><Q><P><L><T>
|
Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.<BOP>
|
O60258
|
Q8TDN1
|
KCNG4_HUMAN
|
Voltage-gated potassium channel subunit Kv6.4
|
Homo
|
<M><P><M><P><S><R><D><G><G><L><H><P><R><H><H><H><Y><G><S><H><S><P><W><S><Q><L><L><S><S><P><M><E><T><P><S><I><K><G><L><Y><Y><R><R><V><R><K><V><G><A><L><D><A><S><P><V><D><L><K><K><E><I><L><I><N><V><G><G><R><R><Y><L><L><P><W><S><T><L><D><R><F><P><L><S><R><L><S><K><L><R><L><C><R><S><Y><E><E><I><V><Q><L><C><D><D><Y><D><E><D><S><Q><E><F><F><F><D><R><S><P><S><A><F><G><V><I><V><S><F><L><A><A><G><K><L><V><L><L><Q><E><M><C><A><L><S><F><Q><E><E><L><A><Y><W><G><I><E><E><A><H><L><E><R><C><C><L><R><K><L><L><R><K><L><E><E><L><E><E><L><A><K><L><H><R><E><D><V><L><R><Q><Q><R><E><T><R><R><P><A><S><H><S><S><R><W><G><L><C><M><N><R><L><R><E><M><V><E><N><P><Q><S><G><L><P><G><K><V><F><A><C><L><S><I><L><F><V><A><T><T><A><V><S><L><C><V><S><T><M><P><D><L><R><A><E><E><D><Q><G><E><C><S><R><K><C><Y><Y><I><F><I><V><E><T><I><C><V><A><W><F><S><L><E><F><C><L><R><F><V><Q><A><Q><D><K><C><Q><F><F><Q><G><P><L><N><I><I><D><I><L><A><I><S><P><Y><Y><V><S><L><A><V><S><E><E><P><P><E><D><G><E><R><P><S><G><S><S><Y><L><E><K><V><G><L><V><L><R><V><L><R><A><L><R><I><L><Y><V><M><R><L><A><R><H><S><L><G><L><Q><T><L><G><L><T><V><R><R><C><T><R><E><F><G><L><L><L><L><F><L><A><V><A><I><T><L><F><S><P><L><V><Y><V><A><E><K><E><S><G><R><V><L><E><F><T><S><I><P><A><S><Y><W><W><A><I><I><S><M><T><T><V><G><Y><G><D><M><V><P><R><S><V><P><G><Q><M><V><A><L><S><S><I><L><S><G><I><L><I><M><A><F><P><A><T><S><I><F><H><T><F><S><H><S><Y><L><E><L><K><K><E><Q><E><Q><L><Q><A><R><L><R><H><L><Q><N><T><G><P><A><S><E><C><E><L><L><D><P><H><V><A><S><E><H><E><L><M><N><D><V><N><D><L><I><L><E><G><P><A><L><P><I><M><H><M>
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Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 .<BOP>
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Q8TDN1
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O43660
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PLRG1_HUMAN
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Pleiotropic regulator 1
|
Homo
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<M><V><E><E><V><Q><K><H><S><V><H><T><L><V><F><R><S><L><K><R><T><H><D><M><F><V><A><D><N><G><K><P><V><P><L><D><E><E><S><H><K><R><K><M><A><I><K><L><R><N><E><Y><G><P><V><L><H><M><P><T><S><K><E><N><L><K><E><K><G><P><Q><N><A><T><D><S><Y><V><H><K><Q><Y><P><A><N><Q><G><Q><E><V><E><Y><F><V><A><G><T><H><P><Y><P><P><G><P><G><V><A><L><T><A><D><T><K><I><Q><R><M><P><S><E><S><A><A><Q><S><L><A><V><A><L><P><L><Q><T><K><A><D><A><N><R><T><A><P><S><G><S><E><Y><R><H><P><G><A><S><D><R><P><Q><P><T><A><M><N><S><I><V><M><E><T><G><N><T><K><N><S><A><L><M><A><K><K><A><P><T><M><P><K><P><Q><W><H><P><P><W><K><L><Y><R><V><I><S><G><H><L><G><W><V><R><C><I><A><V><E><P><G><N><Q><W><F><V><T><G><S><A><D><R><T><I><K><I><W><D><L><A><S><G><K><L><K><L><S><L><T><G><H><I><S><T><V><R><G><V><I><V><S><T><R><S><P><Y><L><F><S><C><G><E><D><K><Q><V><K><C><W><D><L><E><Y><N><K><V><I><R><H><Y><H><G><H><L><S><A><V><Y><G><L><D><L><H><P><T><I><D><V><L><V><T><C><S><R><D><S><T><A><R><I><W><D><V><R><T><K><A><S><V><H><T><L><S><G><H><T><N><A><V><A><T><V><R><C><Q><A><A><E><P><Q><I><I><T><G><S><H><D><T><T><I><R><L><W><D><L><V><A><G><K><T><R><V><T><L><T><N><H><K><K><S><V><R><A><V><V><L><H><P><R><H><Y><T><F><A><S><G><S><P><D><N><I><K><Q><W><K><F><P><D><G><S><F><I><Q><N><L><S><G><H><N><A><I><I><N><T><L><T><V><N><S><D><G><V><L><V><S><G><A><D><N><G><T><M><H><L><W><D><W><R><T><G><Y><N><F><Q><R><V><H><A><A><V><Q><P><G><S><L><D><S><E><S><G><I><F><A><C><A><F><D><Q><S><E><S><R><L><L><T><A><E><A><D><K><T><I><K><V><Y><R><E><D><D><T><A><T><E><E><T><H><P><V><S><W><K><P><E><I><I><K><R><K><R><F>
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Involved in pre-mRNA splicing as component of the spliceosome . Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing .<BOP>
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O43660
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Q96E22
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NGBR_HUMAN
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Nuclear undecaprenyl pyrophosphate synthase 1 homolog
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Homo
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<M><T><G><L><Y><E><L><V><W><R><V><L><H><A><L><L><C><L><H><R><T><L><T><S><W><L><R><V><R><F><G><T><W><N><W><I><W><R><R><C><C><R><A><A><S><A><A><V><L><A><P><L><G><F><T><L><R><K><P><P><A><V><G><R><N><R><R><H><H><R><H><P><R><G><G><S><C><L><A><A><A><H><H><R><M><R><W><R><A><D><G><R><S><L><E><K><L><P><V><H><M><G><L><V><I><T><E><V><E><Q><E><P><S><F><S><D><I><A><S><L><V><V><W><C><M><A><V><G><I><S><Y><I><S><V><Y><D><H><Q><G><I><F><K><R><N><N><S><R><L><M><D><E><I><L><K><Q><Q><Q><E><L><L><G><L><D><C><S><K><Y><S><P><E><F><A><N><S><N><D><K><D><D><Q><V><L><N><C><H><L><A><V><K><V><L><S><P><E><D><G><K><A><D><I><V><R><A><A><Q><D><F><C><Q><L><V><A><Q><K><Q><K><R><P><T><D><L><D><V><D><T><L><A><S><L><L><S><S><N><G><C><P><D><P><D><L><V><L><K><F><G><P><V><D><S><T><L><G><F><L><P><W><H><I><R><L><T><E><I><V><S><L><P><S><H><L><N><I><S><Y><E><D><F><F><S><A><L><R><Q><Y><A><A><C><E><Q><R><L><G><K>
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With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator .<BOP>
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Q96E22
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O43248
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HXC11_HUMAN
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Homeobox protein Hox-3H
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Homo
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<M><F><N><S><V><N><L><G><N><F><C><S><P><S><R><K><E><R><G><A><D><F><G><E><R><G><S><C><A><S><N><L><Y><L><P><S><C><T><Y><Y><M><P><E><F><S><T><V><S><S><F><L><P><Q><A><P><S><R><Q><I><S><Y><P><Y><S><A><Q><V><P><P><V><R><E><V><S><Y><G><L><E><P><S><G><K><W><H><H><R><N><S><Y><S><S><C><Y><A><A><A><D><E><L><M><H><R><E><C><L><P><P><S><T><V><T><E><I><L><M><K><N><E><G><S><Y><G><G><H><H><H><P><S><A><P><H><A><T><P><A><G><F><Y><S><S><V><N><K><N><S><V><L><P><Q><A><F><D><R><F><F><D><N><A><Y><C><G><G><G><D><P><P><A><E><P><P><C><S><G><K><G><E><A><K><G><E><P><E><A><P><P><A><S><G><L><A><S><R><A><E><A><G><A><E><A><E><A><E><E><E><N><T><N><P><S><S><S><G><S><A><H><S><V><A><K><E><P><A><K><G><A><A><P><N><A><P><R><T><R><K><K><R><C><P><Y><S><K><F><Q><I><R><E><L><E><R><E><F><F><F><N><V><Y><I><N><K><E><K><R><L><Q><L><S><R><M><L><N><L><T><D><R><Q><V><K><I><W><F><Q><N><R><R><M><K><E><K><K><L><S><R><D><R><L><Q><Y><F><S><G><N><P><L><L>
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Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.<BOP>
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O43248
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Q5VT66
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MARC1_HUMAN
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Molybdenum cofactor sulfurase C-terminal domain-containing protein 1
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Homo
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<M><G><A><A><G><S><S><A><L><A><R><F><V><L><L><A><Q><S><R><P><G><W><L><G><V><A><A><L><G><L><T><A><V><A><L><G><A><V><A><W><R><R><A><W><P><T><R><R><R><R><L><L><Q><Q><V><G><T><V><A><Q><L><W><I><Y><P><V><K><S><C><K><G><V><P><V><S><E><A><E><C><T><A><M><G><L><R><S><G><N><L><R><D><R><F><W><L><V><I><N><Q><E><G><N><M><V><T><A><R><Q><E><P><R><L><V><L><I><S><L><T><C><D><G><D><T><L><T><L><S><A><A><Y><T><K><D><L><L><L><P><I><K><T><P><T><T><N><A><V><H><K><C><R><V><H><G><L><E><I><E><G><R><D><C><G><E><A><T><A><Q><W><I><T><S><F><L><K><S><Q><P><Y><R><L><V><H><F><E><P><H><M><R><P><R><R><P><H><Q><I><A><D><L><F><R><P><K><D><Q><I><A><Y><S><D><T><S><P><F><L><I><L><S><E><A><S><L><A><D><L><N><S><R><L><E><K><K><V><K><A><T><N><F><R><P><N><I><V><I><S><G><C><D><V><Y><A><E><D><S><W><D><E><L><L><I><G><D><V><E><L><K><R><V><M><A><C><S><R><C><I><L><T><T><V><D><P><D><T><G><V><M><S><R><K><E><P><L><E><T><L><K><S><Y><R><Q><C><D><P><S><E><R><K><L><Y><G><K><S><P><L><F><G><Q><Y><F><V><L><E><N><P><G><T><I><K><V><G><D><P><V><Y><L><L><G><Q>
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Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles . As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability . May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis . Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction .<BOP>
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Q5VT66
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Q6ZNE9
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RUFY4_HUMAN
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RUN and FYVE domain-containing protein 4
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Homo
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<M><A><E><E><G><A><I><L><K><V><T><K><D><L><R><A><A><V><S><A><I><L><Q><G><Y><G><D><G><Q><G><P><V><T><D><T><S><A><E><L><H><R><L><C><G><C><L><E><L><L><L><Q><F><D><Q><K><E><Q><K><S><F><L><G><P><R><K><D><Y><W><D><F><L><C><T><A><L><R><R><Q><R><G><N><M><E><P><I><H><F><V><R><S><Q><D><K><L><K><T><P><L><G><K><G><R><A><F><I><R><F><C><L><A><R><G><Q><L><A><E><A><L><Q><L><C><L><L><N><S><E><L><T><R><E><W><Y><G><P><R><S><P><L><L><C><P><E><R><Q><E><D><I><L><D><S><L><Y><A><L><N><G><V><A><F><E><L><D><L><Q><Q><P><D><L><D><G><A><W><P><M><F><S><E><S><R><C><S><S><S><T><Q><T><Q><G><R><R><P><R><K><N><K><D><A><P><K><K><I><P><A><A><Y><G><G><P><E><N><V><Q><I><E><D><S><H><T><S><Q><A><I><C><L><Q><D><A><P><S><G><Q><Q><L><A><G><L><P><R><S><Q><Q><Q><R><H><L><P><F><F><L><E><K><K><G><E><S><S><R><K><H><R><Y><P><Q><S><M><W><E><P><E><G><K><E><L><Q><L><D><Q><E><E><R><A><P><W><I><E><I><F><L><G><N><S><T><P><S><T><Q><G><Q><G><K><G><A><M><G><T><Q><K><E><V><I><G><M><E><A><E><V><T><G><V><L><L><V><A><E><G><Q><R><T><T><E><G><T><H><K><K><E><A><E><W><S><H><V><Q><R><L><L><M><P><S><P><R><G><A><V><E><G><A><V><S><G><S><R><Q><G><S><G><G><S><S><I><L><G><E><P><W><V><L><Q><G><H><A><T><K><E><D><S><T><V><E><N><P><Q><V><Q><T><E><V><T><L><V><A><R><R><E><E><Q><A><E><V><S><L><Q><D><E><I><K><S><L><R><L><G><L><R><K><A><E><E><Q><A><Q><R><Q><E><Q><L><L><R><E><Q><E><G><E><L><Q><A><L><R><E><Q><L><S><R><C><Q><E><E><R><A><E><L><Q><A><Q><L><E><Q><K><Q><Q><E><A><E><R><R><D><A><M><Y><Q><E><E><L><G><G><Q><R><D><L><V><Q><A><M><K><R><R><V><L><E><L><I><Q><E><K><D><R><L><W><Q><R><L><Q><H><L><S><S><M><A><P><E><C><C><V><A><C><S><K><I><F><G><R><F><S><R><R><Y><P><C><R><L><C><G><G><L><L><C><H><A><C><S><M><D><Y><K><K><R><D><R><C><C><P><P><C><A><Q><G><R><E><A><Q><V><T>
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Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.<BOP>
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Q6ZNE9
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Q5MY95
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ENTP8_HUMAN
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Ectonucleoside triphosphate diphosphohydrolase 8
|
Homo
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<M><G><L><S><R><K><E><Q><V><F><L><A><L><L><G><A><S><G><V><S><G><L><T><A><L><I><L><L><L><V><E><A><T><S><V><L><L><P><T><D><I><K><F><G><I><V><F><D><A><G><S><S><H><T><S><L><F><L><Y><Q><W><L><A><N><K><E><N><G><T><G><V><V><S><Q><A><L><A><C><Q><V><E><G><P><G><I><S><S><Y><T><S><N><A><A><Q><A><G><E><S><L><Q><G><C><L><E><E><A><L><V><L><I><P><E><A><Q><H><R><K><T><P><T><F><L><G><A><T><A><G><M><R><L><L><S><R><K><N><S><S><Q><A><R><D><I><F><A><A><V><T><Q><V><L><G><R><S><P><V><D><F><W><G><A><E><L><L><A><G><Q><A><E><G><A><F><G><W><I><T><V><N><Y><G><L><G><T><L><V><K><Y><S><F><T><G><E><W><I><Q><P><P><E><E><M><L><V><G><A><L><D><M><G><G><A><S><T><Q><I><T><F><V><P><G><G><P><I><L><D><K><S><T><Q><A><D><F><R><L><Y><G><S><D><Y><S><V><Y><T><H><S><Y><L><C><F><G><R><D><Q><M><L><S><R><L><L><V><G><L><V><Q><S><R><P><A><A><L><L><R><H><P><C><Y><L><S><G><Y><Q><T><T><L><A><L><G><P><L><Y><E><S><P><C><V><H><A><T><P><P><L><S><L><P><Q><N><L><T><V><E><G><T><G><N><P><G><A><C><V><S><A><I><R><E><L><F><N><F><S><S><C><Q><G><Q><E><D><C><A><F><D><G><V><Y><Q><P><P><L><R><G><Q><F><Y><A><F><S><N><F><Y><Y><T><F><H><F><L><N><L><T><S><R><Q><P><L><S><T><V><N><A><T><I><W><E><F><C><Q><R><P><W><K><L><V><E><A><S><Y><P><G><Q><D><R><W><L><R><D><Y><C><A><S><G><L><Y><I><L><T><L><L><H><E><G><Y><G><F><S><E><E><T><W><P><S><L><E><F><R><K><Q><A><G><G><V><D><I><G><W><T><L><G><Y><M><L><N><L><T><G><M><I><P><A><D><A><P><A><Q><W><R><A><E><S><Y><G><V><W><V><A><K><V><V><F><M><V><L><A><L><V><A><V><V><G><A><A><L><V><Q><L><F><W><L><Q><D>
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Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.<BOP>
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Q5MY95
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Q9BT73
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PSMG3_HUMAN
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Proteasome assembly chaperone 3
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Homo
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<M><E><D><T><P><L><V><I><S><K><Q><K><T><E><V><V><C><G><V><P><T><Q><V><V><C><T><A><F><S><S><H><I><L><V><V><V><T><Q><F><G><K><M><G><T><L><V><S><L><E><P><S><S><V><A><S><D><V><S><K><P><V><L><T><T><K><V><L><L><G><Q><D><E><P><L><I><H><V><F><A><K><N><L><V><A><F><V><S><Q><E><A><G><N><R><A><V><L><L><A><V><A><V><K><D><K><S><M><E><G><L><K><A><L><R><E><V><I><R><V><C><Q><V><W>
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Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.<BOP>
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Q9BT73
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Q9H7J1
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PPR3E_HUMAN
|
Protein phosphatase 1 regulatory subunit 3E
|
Homo
|
<M><S><R><E><R><P><P><G><T><D><I><P><R><N><L><S><F><I><A><A><L><T><E><R><A><Y><Y><R><S><Q><R><P><S><L><E><E><E><P><E><E><E><P><G><E><G><G><T><R><F><G><A><R><S><R><A><H><A><P><S><R><G><R><R><A><R><S><A><P><A><G><G><G><G><A><R><A><P><R><S><R><S><P><D><T><R><K><R><V><R><F><A><D><A><L><G><L><E><L><A><V><V><R><R><F><R><P><G><E><L><P><R><V><P><R><H><V><Q><I><Q><L><Q><R><D><A><L><R><H><F><A><P><C><Q><P><R><A><R><G><L><Q><E><A><R><A><A><L><E><P><A><S><E><P><G><F><A><A><R><L><L><T><Q><R><I><C><L><E><R><A><E><A><G><P><L><G><V><A><G><S><A><R><V><V><D><L><A><Y><E><K><R><V><S><V><R><W><S><A><D><G><W><R><S><Q><R><E><A><P><A><A><Y><A><G><P><A><P><P><P><P><R><A><D><R><F><A><F><R><L><P><A><P><P><I><G><G><A><L><L><F><A><L><R><Y><R><V><T><G><H><E><F><W><D><N><N><G><G><R><D><Y><A><L><R><G><P><E><H><P><G><S><G><G><A><P><E><P><Q><G><W><I><H><F><I>
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Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.<BOP>
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Q9H7J1
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P28222
|
5HT1B_HUMAN
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Serotonin receptor 1B
|
Homo
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<M><E><E><P><G><A><Q><C><A><P><P><P><P><A><G><S><E><T><W><V><P><Q><A><N><L><S><S><A><P><S><Q><N><C><S><A><K><D><Y><I><Y><Q><D><S><I><S><L><P><W><K><V><L><L><V><M><L><L><A><L><I><T><L><A><T><T><L><S><N><A><F><V><I><A><T><V><Y><R><T><R><K><L><H><T><P><A><N><Y><L><I><A><S><L><A><V><T><D><L><L><V><S><I><L><V><M><P><I><S><T><M><Y><T><V><T><G><R><W><T><L><G><Q><V><V><C><D><F><W><L><S><S><D><I><T><C><C><T><A><S><I><L><H><L><C><V><I><A><L><D><R><Y><W><A><I><T><D><A><V><E><Y><S><A><K><R><T><P><K><R><A><A><V><M><I><A><L><V><W><V><F><S><I><S><I><S><L><P><P><F><F><W><R><Q><A><K><A><E><E><E><V><S><E><C><V><V><N><T><D><H><I><L><Y><T><V><Y><S><T><V><G><A><F><Y><F><P><T><L><L><L><I><A><L><Y><G><R><I><Y><V><E><A><R><S><R><I><L><K><Q><T><P><N><R><T><G><K><R><L><T><R><A><Q><L><I><T><D><S><P><G><S><T><S><S><V><T><S><I><N><S><R><V><P><D><V><P><S><E><S><G><S><P><V><Y><V><N><Q><V><K><V><R><V><S><D><A><L><L><E><K><K><K><L><M><A><A><R><E><R><K><A><T><K><T><L><G><I><I><L><G><A><F><I><V><C><W><L><P><F><F><I><I><S><L><V><M><P><I><C><K><D><A><C><W><F><H><L><A><I><F><D><F><F><T><W><L><G><Y><L><N><S><L><I><N><P><I><I><Y><T><M><S><N><E><D><F><K><Q><A><F><H><K><L><I><R><F><K><C><T><S>
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.<BOP>
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P28222
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Q8NC51
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PAIRB_HUMAN
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SERPINE1 mRNA-binding protein 1
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Homo
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<M><P><G><H><L><Q><E><G><F><G><C><V><V><T><N><R><F><D><Q><L><F><D><D><E><S><D><P><F><E><V><L><K><A><A><E><N><K><K><K><E><A><G><G><G><G><V><G><G><P><G><A><K><S><A><A><Q><A><A><A><Q><T><N><S><N><A><A><G><K><Q><L><R><K><E><S><Q><K><D><R><K><N><P><L><P><P><S><V><G><V><V><D><K><K><E><E><T><Q><P><P><V><A><L><K><K><E><G><I><R><R><V><G><R><R><P><D><Q><Q><L><Q><G><E><G><K><I><I><D><R><R><P><E><R><R><P><P><R><E><R><R><F><E><K><P><L><E><E><K><G><E><G><G><E><F><S><V><D><R><P><I><I><D><R><P><I><R><G><R><G><G><L><G><R><G><R><G><G><R><G><R><G><M><G><R><G><D><G><F><D><S><R><G><K><R><E><F><D><R><H><S><G><S><D><R><S><S><F><S><H><Y><S><G><L><K><H><E><D><K><R><G><G><S><G><S><H><N><W><G><T><V><K><D><E><L><T><E><S><P><K><Y><I><Q><K><Q><I><S><Y><N><Y><S><D><L><D><Q><S><N><V><T><E><E><T><P><E><G><E><E><H><H><P><V><A><D><T><E><N><K><E><N><E><V><E><E><V><K><E><E><G><P><K><E><M><T><L><D><E><W><K><A><I><Q><N><K><D><R><A><K><V><E><F><N><I><R><K><P><N><E><G><A><D><G><Q><W><K><K><G><F><V><L><H><K><S><K><S><E><E><A><H><A><E><D><S><V><M><D><H><H><F><R><K><P><A><N><D><I><T><S><Q><L><E><I><N><F><G><D><L><G><R><P><G><R><G><G><R><G><G><R><G><G><R><G><R><G><G><R><P><N><R><G><S><R><T><D><K><S><S><A><S><A><P><D><V><D><D><P><E><A><F><P><A><L><A>
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May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation .<BOP>
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Q8NC51
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Q9C0C6
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CIPC_HUMAN
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CLOCK-interacting circadian protein
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Homo
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<M><E><R><K><N><P><S><R><E><S><P><R><R><L><S><A><K><V><G><K><G><T><E><M><K><K><V><A><R><Q><L><G><M><A><A><A><E><S><D><K><D><S><G><F><S><D><G><S><S><E><C><L><S><S><A><E><Q><M><E><S><E><D><M><L><S><A><L><G><W><S><R><E><D><R><P><R><Q><N><S><K><T><A><K><N><A><F><P><T><L><S><P><M><V><V><M><K><N><V><L><V><K><Q><G><S><S><S><S><Q><L><Q><S><W><T><V><Q><P><S><F><E><V><I><S><A><Q><P><Q><L><L><F><L><H><P><P><V><P><S><P><V><S><P><C><H><T><G><E><K><K><S><D><S><R><N><Y><L><P><I><L><N><S><Y><T><K><I><A><P><H><P><G><K><R><G><L><S><L><G><P><E><E><K><G><T><S><G><V><Q><K><K><I><C><T><E><R><L><G><P><S><L><S><S><S><E><P><T><K><A><G><A><V><P><S><S><P><S><T><P><A><P><P><S><A><K><L><A><E><D><S><A><L><Q><G><V><P><S><L><V><A><G><G><S><P><Q><T><L><Q><P><V><S><S><S><H><V><A><K><A><P><S><L><T><F><A><S><P><A><S><P><V><C><A><S><D><S><T><L><H><G><L><E><S><N><S><P><L><S><P><L><S><A><N><Y><S><S><P><L><W><A><A><E><H><L><C><R><S><P><D><I><F><S><E><Q><R><Q><S><K><H><R><R><F><Q><N><T><L><V><V><L><H><K><S><G><L><L><E><I><T><L><K><T><K><E><L><I><R><Q><N><Q><A><T><Q><V><E><L><D><Q><L><K><E><Q><T><Q><L><F><I><E><A><T><K><S><R><A><P><Q><A><W><A><K><L><Q><A><S><L><T><P><G><S><S><N><T><G><S><D><L><E><A><F><S><D><H><P><A><I>
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Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.<BOP>
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Q9C0C6
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Q8N5M1
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ATPF2_HUMAN
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ATP12 homolog
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Homo
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<M><W><R><S><C><L><R><L><R><D><G><G><R><R><L><L><N><R><P><A><G><G><P><S><A><S><M><S><P><G><P><T><I><P><S><P><A><R><A><Y><A><P><P><T><E><R><K><R><F><Y><Q><N><V><S><I><T><Q><G><E><G><G><F><E><I><N><L><D><H><R><K><L><K><T><P><Q><A><K><L><F><T><V><P><S><E><A><L><A><I><A><V><A><T><E><W><D><S><Q><Q><D><T><I><K><Y><Y><T><M><H><L><T><T><L><C><N><T><S><L><D><N><P><T><Q><R><N><K><D><Q><L><I><R><A><A><V><K><F><L><D><T><D><T><I><C><Y><R><V><E><E><P><E><T><L><V><E><L><Q><R><N><E><W><D><P><I><I><E><W><A><E><K><R><Y><G><V><E><I><S><S><S><T><S><I><M><G><P><S><I><P><A><K><T><R><E><V><L><V><S><H><L><A><S><Y><N><T><W><A><L><Q><G><I><E><F><V><A><A><Q><L><K><S><M><V><L><T><L><G><L><I><D><L><R><L><T><V><E><Q><A><V><L><L><S><R><L><E><E><E><Y><Q><I><Q><K><W><G><N><I><E><W><A><H><D><Y><E><L><Q><E><L><R><A><R><T><A><A><G><T><L><F><I><H><L><C><S><E><S><T><T><V><K><H><K><L><L><K><E>
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May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).<BOP>
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Q8N5M1
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O95528
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GTR10_HUMAN
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Glucose transporter type 10
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Homo
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<M><G><H><S><P><P><V><L><P><L><C><A><S><V><S><L><L><G><G><L><T><F><G><Y><E><L><A><V><I><S><G><A><L><L><P><L><Q><L><D><F><G><L><S><C><L><E><Q><E><F><L><V><G><S><L><L><L><G><A><L><L><A><S><L><V><G><G><F><L><I><D><C><Y><G><R><K><Q><A><I><L><G><S><N><L><V><L><L><A><G><S><L><T><L><G><L><A><G><S><L><A><W><L><V><L><G><R><A><V><V><G><F><A><I><S><L><S><S><M><A><C><C><I><Y><V><S><E><L><V><G><P><R><Q><R><G><V><L><V><S><L><Y><E><A><G><I><T><V><G><I><L><L><S><Y><A><L><N><Y><A><L><A><G><T><P><W><G><W><R><H><M><F><G><W><A><T><A><P><A><V><L><Q><S><L><S><L><L><F><L><P><A><G><T><D><E><T><A><T><H><K><D><L><I><P><L><Q><G><G><E><A><P><K><L><G><P><G><R><P><R><Y><S><F><L><D><L><F><R><A><R><D><N><M><R><G><R><T><T><V><G><L><G><L><V><L><F><Q><Q><L><T><G><Q><P><N><V><L><C><Y><A><S><T><I><F><S><S><V><G><F><H><G><G><S><S><A><V><L><A><S><V><G><L><G><A><V><K><V><A><A><T><L><T><A><M><G><L><V><D><R><A><G><R><R><A><L><L><L><A><G><C><A><L><M><A><L><S><V><S><G><I><G><L><V><S><F><A><V><P><M><D><S><G><P><S><C><L><A><V><P><N><A><T><G><Q><T><G><L><P><G><D><S><G><L><L><Q><D><S><S><L><P><P><I><P><R><T><N><E><D><Q><R><E><P><I><L><S><T><A><K><K><T><K><P><H><P><R><S><G><D><P><S><A><P><P><R><L><A><L><S><S><A><L><P><G><P><P><L><P><A><R><G><H><A><L><L><R><W><T><A><L><L><C><L><M><V><F><V><S><A><F><S><F><G><F><G><P><V><T><W><L><V><L><S><E><I><Y><P><V><E><I><R><G><R><A><F><A><F><C><N><S><F><N><W><A><A><N><L><F><I><S><L><S><F><L><D><L><I><G><T><I><G><L><S><W><T><F><L><L><Y><G><L><T><A><V><L><G><L><G><F><I><Y><L><F><V><P><E><T><K><G><Q><S><L><A><E><I><D><Q><Q><F><Q><K><R><R><F><T><L><S><F><G><H><R><Q><N><S><T><G><I><P><Y><S><R><I><E><I><S><A><A><S>
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Facilitative glucose transporter required for the development of the cardiovascular system.<BOP>
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O95528
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Q9H082
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RB33B_HUMAN
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Ras-related protein Rab-33B
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Homo
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<M><A><E><E><M><E><S><S><L><E><A><S><F><S><S><S><G><A><V><S><G><A><S><G><F><L><P><P><A><R><S><R><I><F><K><I><I><V><I><G><D><S><N><V><G><K><T><C><L><T><Y><R><F><C><A><G><R><F><P><D><R><T><E><A><T><I><G><V><D><F><R><E><R><A><V><E><I><D><G><E><R><I><K><I><Q><L><W><D><T><A><G><Q><E><R><F><R><K><S><M><V><Q><H><Y><Y><R><N><V><H><A><V><V><F><V><Y><D><M><T><N><M><A><S><F><H><S><L><P><S><W><I><E><E><C><K><Q><H><L><L><A><N><D><I><P><R><I><L><V><G><N><K><C><D><L><R><S><A><I><Q><V><P><T><D><L><A><Q><K><F><A><D><T><H><S><M><P><L><F><E><T><S><A><K><N><P><N><D><N><D><H><V><E><A><I><F><M><T><L><A><H><K><L><K><S><H><K><P><L><M><L><S><Q><P><P><D><N><G><I><I><L><K><P><E><P><K><P><A><M><T><C><W><C>
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Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation.<BOP>
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Q9H082
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Q13227
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GPS2_HUMAN
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G protein pathway suppressor 2
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Homo
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<M><P><A><L><L><E><R><P><K><L><S><N><A><M><A><R><A><L><H><R><H><I><M><M><E><R><E><R><K><R><Q><E><E><E><E><V><D><K><M><M><E><Q><K><M><K><E><E><Q><E><R><R><K><K><K><E><M><E><E><R><M><S><L><E><E><T><K><E><Q><I><L><K><L><E><E><K><L><L><A><L><Q><E><E><K><H><Q><L><F><L><Q><L><K><K><V><L><H><E><E><E><K><R><R><R><K><E><Q><S><D><L><T><T><L><T><S><A><A><Y><Q><Q><S><L><T><V><H><T><G><T><H><L><L><S><M><Q><G><S><P><G><G><H><N><R><P><G><T><L><M><A><A><D><R><A><K><Q><M><F><G><P><Q><V><L><T><T><R><H><Y><V><G><S><A><A><A><F><A><G><T><P><E><H><G><Q><F><Q><G><S><P><G><G><A><Y><G><T><A><Q><P><P><P><H><Y><G><P><T><Q><P><A><Y><S><P><S><Q><Q><L><R><A><P><S><A><F><P><A><V><Q><Y><L><S><Q><P><Q><P><Q><P><Y><A><V><H><G><H><F><Q><P><T><Q><T><G><F><L><Q><P><G><G><A><L><S><L><Q><K><Q><M><E><H><A><N><Q><Q><T><G><F><S><D><S><S><S><L><R><P><M><H><P><Q><A><L><H><P><A><P><G><L><L><A><S><P><Q><L><P><V><Q><M><Q><P><A><G><K><S><G><F><A><A><T><S><Q><P><G><P><R><L><P><F><I><Q><H><S><Q><N><P><R><F><Y><H><K>
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(Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A.<BOP>
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Q13227
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Q5T0B9
|
ZN362_HUMAN
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Zinc finger protein 362
|
Homo
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<M><S><R><S><S><P><S><G><K><G><H><S><R><M><A><E><P><R><F><N><N><P><Y><F><W><P><P><P><P><T><M><P><S><Q><L><D><N><L><V><L><I><N><K><I><K><E><Q><L><M><A><E><K><I><R><P><P><H><L><P><P><T><S><A><S><S><Q><Q><P><L><L><V><P><P><A><P><A><E><S><S><Q><A><V><M><S><L><P><K><L><Q><Q><V><P><G><L><H><P><Q><A><V><P><Q><P><D><V><A><L><H><A><R><P><A><T><S><T><V><T><G><L><G><L><S><T><R><T><P><S><V><S><T><S><E><S><S><A><G><A><G><T><G><T><G><T><S><T><P><S><T><P><T><T><T><S><Q><S><R><L><I><A><S><S><P><T><L><I><S><G><I><T><S><P><P><L><L><D><S><I><K><T><I><Q><G><H><G><L><L><G><P><P><K><S><E><R><G><R><K><K><I><K><A><E><N><P><G><G><P><P><V><L><V><V><P><Y><P><I><L><A><S><G><E><T><A><K><E><G><K><T><Y><R><C><K><V><C><P><L><T><F><F><T><K><S><E><M><Q><I><H><S><K><S><H><T><E><A><K><P><H><K><C><P><H><C><S><K><S><F><A><N><A><S><Y><L><A><Q><H><L><R><I><H><L><G><V><K><P><Y><H><C><S><Y><C><D><K><S><F><R><Q><L><S><H><L><Q><Q><H><T><R><I><H><T><G><D><R><P><Y><K><C><P><H><P><G><C><E><K><A><F><T><Q><L><S><N><L><Q><S><H><Q><R><Q><H><N><K><D><K><P><Y><K><C><P><N><C><Y><R><A><Y><S><D><S><A><S><L><Q><I><H><L><S><A><H><A><I><K><H><A><K><A><Y><C><C><S><M><C><G><R><A><Y><T><S><E><T><Y><L><M><K><H><M><S><K><H><T><V><V><E><H><L><V><S><H><H><S><P><Q><R><T><E><S><P><G><I><P><V><R><I><S><L><I>
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May be involved in transcriptional regulation.<BOP>
|
Q5T0B9
|
P35240
|
MERL_HUMAN
|
Schwannomin
|
Homo
|
<M><A><G><A><I><A><S><R><M><S><F><S><S><L><K><R><K><Q><P><K><T><F><T><V><R><I><V><T><M><D><A><E><M><E><F><N><C><E><M><K><W><K><G><K><D><L><F><D><L><V><C><R><T><L><G><L><R><E><T><W><F><F><G><L><Q><Y><T><I><K><D><T><V><A><W><L><K><M><D><K><K><V><L><D><H><D><V><S><K><E><E><P><V><T><F><H><F><L><A><K><F><Y><P><E><N><A><E><E><E><L><V><Q><E><I><T><Q><H><L><F><F><L><Q><V><K><K><Q><I><L><D><E><K><I><Y><C><P><P><E><A><S><V><L><L><A><S><Y><A><V><Q><A><K><Y><G><D><Y><D><P><S><V><H><K><R><G><F><L><A><Q><E><E><L><L><P><K><R><V><I><N><L><Y><Q><M><T><P><E><M><W><E><E><R><I><T><A><W><Y><A><E><H><R><G><R><A><R><D><E><A><E><M><E><Y><L><K><I><A><Q><D><L><E><M><Y><G><V><N><Y><F><A><I><R><N><K><K><G><T><E><L><L><L><G><V><D><A><L><G><L><H><I><Y><D><P><E><N><R><L><T><P><K><I><S><F><P><W><N><E><I><R><N><I><S><Y><S><D><K><E><F><T><I><K><P><L><D><K><K><I><D><V><F><K><F><N><S><S><K><L><R><V><N><K><L><I><L><Q><L><C><I><G><N><H><D><L><F><M><R><R><R><K><A><D><S><L><E><V><Q><Q><M><K><A><Q><A><R><E><E><K><A><R><K><Q><M><E><R><Q><R><L><A><R><E><K><Q><M><R><E><E><A><E><R><T><R><D><E><L><E><R><R><L><L><Q><M><K><E><E><A><T><M><A><N><E><A><L><M><R><S><E><E><T><A><D><L><L><A><E><K><A><Q><I><T><E><E><E><A><K><L><L><A><Q><K><A><A><E><A><E><Q><E><M><Q><R><I><K><A><T><A><I><R><T><E><E><E><K><R><L><M><E><Q><K><V><L><E><A><E><V><L><A><L><K><M><A><E><E><S><E><R><R><A><K><E><A><D><Q><L><K><Q><D><L><Q><E><A><R><E><A><E><R><R><A><K><Q><K><L><L><E><I><A><T><K><P><T><Y><P><P><M><N><P><I><P><A><P><L><P><P><D><I><P><S><F><N><L><I><G><D><S><L><S><F><D><F><K><D><T><D><M><K><R><L><S><M><E><I><E><K><E><K><V><E><Y><M><E><K><S><K><H><L><Q><E><Q><L><N><E><L><K><T><E><I><E><A><L><K><L><K><E><R><E><T><A><L><D><I><L><H><N><E><N><S><D><R><G><G><S><S><K><H><N><T><I><K><K><L><T><L><Q><S><A><K><S><R><V><A><F><F><E><E><L>
|
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.<BOP>
|
P35240
|
Q96CS2
|
HAUS1_HUMAN
|
Enhancer of invasion-cluster
|
Homo
|
<M><E><P><Q><E><E><R><E><T><Q><V><A><A><W><L><K><K><I><F><G><D><H><P><I><P><Q><Y><E><V><N><P><R><T><T><E><I><L><H><H><L><S><E><R><N><R><V><R><D><R><D><V><Y><L><V><I><E><D><L><K><Q><K><A><S><E><Y><E><S><E><A><K><Y><L><Q><D><L><L><M><E><S><V><N><F><S><P><A><N><L><S><S><T><G><S><R><Y><L><N><A><L><V><D><S><A><V><A><L><E><T><K><D><T><S><L><A><S><F><I><P><A><V><N><D><L><T><S><D><L><F><R><T><K><S><K><S><E><E><I><K><I><E><L><E><K><L><E><K><N><L><T><A><T><L><V><L><E><K><C><L><Q><E><D><V><K><K><A><E><L><H><L><S><T><E><R><A><K><V><D><N><R><R><Q><N><M><D><F><L><K><A><K><S><E><E><F><R><F><G><I><K><A><A><E><E><Q><L><S><A><R><G><M><D><A><S><L><S><H><Q><S><L><V><A><L><S><E><K><L><A><R><L><K><Q><Q><T><I><P><L><K><K><K><L><E><S><Y><L><D><L><M><P><N><P><S><L><A><Q><V><K><I><E><E><A><K><R><E><L><D><S><I><E><A><E><L><T><R><R><V><D><M><M><E><L>
|
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.<BOP>
|
Q96CS2
|
Q6A162
|
K1C40_HUMAN
|
Type I hair keratin Ka36
|
Homo
|
<M><T><S><D><C><S><S><T><H><C><S><P><E><S><C><G><T><A><S><G><C><A><P><A><S><S><C><S><V><E><T><A><C><L><P><G><T><C><A><T><S><R><C><Q><T><P><S><F><L><S><R><S><R><G><L><T><G><C><L><L><P><C><Y><F><T><G><S><C><N><S><P><C><L><V><G><N><C><A><W><C><E><D><G><V><F><T><S><N><E><K><E><T><M><Q><F><L><N><D><R><L><A><S><Y><L><E><K><V><R><S><L><E><E><T><N><A><E><L><E><S><R><I><Q><E><Q><C><E><Q><D><I><P><M><V><C><P><D><Y><Q><R><Y><F><N><T><I><E><D><L><Q><Q><K><I><L><C><T><K><A><E><N><S><R><L><A><V><Q><L><D><N><C><K><L><A><T><D><D><F><K><S><K><Y><E><S><E><L><S><L><R><Q><L><L><E><A><D><I><S><S><L><H><G><I><L><E><E><L><T><L><C><K><S><D><L><E><A><H><V><E><S><L><K><E><D><L><L><C><L><K><K><N><H><E><E><E><V><N><L><L><R><E><Q><L><G><D><R><L><S><V><E><L><D><T><A><P><T><L><D><L><N><R><V><L><D><E><M><R><C><Q><C><E><T><V><L><A><N><N><R><R><E><A><E><E><W><L><A><V><Q><T><E><E><L><N><Q><Q><Q><L><S><S><A><E><Q><L><Q><G><C><Q><M><E><I><L><E><L><K><R><T><A><S><A><L><E><I><E><L><Q><A><Q><Q><S><L><T><E><S><L><E><C><T><V><A><E><T><E><A><Q><Y><S><S><Q><L><A><Q><I><Q><C><L><I><D><N><L><E><N><Q><L><A><E><I><R><C><D><L><E><R><Q><N><Q><E><Y><Q><V><L><L><D><V><K><A><R><L><E><G><E><I><N><T><Y><W><G><L><L><D><S><E><D><S><R><L><S><C><S><P><C><S><T><T><C><T><S><S><N><T><C><E><P><C><S><A><Y><V><I><C><T><V><E><N><C><C><L>
|
May play a role in late hair differentiation.<BOP>
|
Q6A162
|
P21589
|
5NTD_HUMAN
|
Ecto-5'-nucleotidase
|
Homo
|
<M><C><P><R><A><A><R><A><P><A><T><L><L><L><A><L><G><A><V><L><W><P><A><A><G><A><W><E><L><T><I><L><H><T><N><D><V><H><S><R><L><E><Q><T><S><E><D><S><S><K><C><V><N><A><S><R><C><M><G><G><V><A><R><L><F><T><K><V><Q><Q><I><R><R><A><E><P><N><V><L><L><L><D><A><G><D><Q><Y><Q><G><T><I><W><F><T><V><Y><K><G><A><E><V><A><H><F><M><N><A><L><R><Y><D><A><M><A><L><G><N><H><E><F><D><N><G><V><E><G><L><I><E><P><L><L><K><E><A><K><F><P><I><L><S><A><N><I><K><A><K><G><P><L><A><S><Q><I><S><G><L><Y><L><P><Y><K><V><L><P><V><G><D><E><V><V><G><I><V><G><Y><T><S><K><E><T><P><F><L><S><N><P><G><T><N><L><V><F><E><D><E><I><T><A><L><Q><P><E><V><D><K><L><K><T><L><N><V><N><K><I><I><A><L><G><H><S><G><F><E><M><D><K><L><I><A><Q><K><V><R><G><V><D><V><V><V><G><G><H><S><N><T><F><L><Y><T><G><N><P><P><S><K><E><V><P><A><G><K><Y><P><F><I><V><T><S><D><D><G><R><K><V><P><V><V><Q><A><Y><A><F><G><K><Y><L><G><Y><L><K><I><E><F><D><E><R><G><N><V><I><S><S><H><G><N><P><I><L><L><N><S><S><I><P><E><D><P><S><I><K><A><D><I><N><K><W><R><I><K><L><D><N><Y><S><T><Q><E><L><G><K><T><I><V><Y><L><D><G><S><S><Q><S><C><R><F><R><E><C><N><M><G><N><L><I><C><D><A><M><I><N><N><N><L><R><H><T><D><E><M><F><W><N><H><V><S><M><C><I><L><N><G><G><G><I><R><S><P><I><D><E><R><N><N><G><T><I><T><W><E><N><L><A><A><V><L><P><F><G><G><T><F><D><L><V><Q><L><K><G><S><T><L><K><K><A><F><E><H><S><V><H><R><Y><G><Q><S><T><G><E><F><L><Q><V><G><G><I><H><V><V><Y><D><L><S><R><K><P><G><D><R><V><V><K><L><D><V><L><C><T><K><C><R><V><P><S><Y><D><P><L><K><M><D><E><V><Y><K><V><I><L><P><N><F><L><A><N><G><G><D><G><F><Q><M><I><K><D><E><L><L><R><H><D><S><G><D><Q><D><I><N><V><V><S><T><Y><I><S><K><M><K><V><I><Y><P><A><V><E><G><R><I><K><F><S><T><G><S><H><C><H><G><S><F><S><L><I><F><L><S><L><W><A><V><I><F><V><L><Y><Q>
|
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.<BOP>
|
P21589
|
A0A0C4DH30
|
HV316_HUMAN
|
Probable non-functional immunoglobulin heavy variable 3-16
|
Homo
|
<M><E><F><G><L><S><W><V><F><L><A><G><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><S><N><S><D><M><N><W><A><R><K><A><P><G><K><G><L><E><W><V><S><G><V><S><W><N><G><S><R><T><H><Y><V><D><S><V><K><R><R><F><I><I><S><R><D><N><S><R><N><S><L><Y><L><Q><K><N><R><R><R><A><E><D><M><A><V><Y><Y><C><V><R>
|
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection
|
A0A0C4DH30
|
P01764
|
HV323_HUMAN
|
Ig heavy chain V-III region ZAP
|
Homo
|
<M><E><F><G><L><S><W><L><F><L><V><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><A><M><S><W><V><R><Q><A><P><G><K><G><L><E><W><V><S><A><I><S><G><S><G><G><S><T><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><K>
|
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
|
P01764
|
Q8IW36
|
ZN695_HUMAN
|
Zinc finger protein SBZF3
|
Homo
|
<M><G><L><L><A><F><R><D><V><A><L><E><F><S><P><E><E><W><E><C><L><D><P><A><Q><R><S><L><Y><R><D><V><M><L><E><N><Y><R><N><L><I><S><L><G><E><D><S><F><N><M><Q><F><L><F><H><S><L><A><M><S><K><P><E><L><I><I><C><L><E><A><R><K><E><P><W><N><V><N><T><E><K><T><A><R><H><S><V><L><S><S><Y><L><T><E><D><I><L><P><E><Q><G><L><Q><V><S><F><Q><K><V><M><L><R><R><Y><E><R><C><C><L><E><K><L><R><L><R><N><D><W><E><I><V><G><E><W><K><G><Q><K><A><S><Y><N><G><L><D><L><C><S><A><T><T><H><S><K><N><F><Q><C><N><K><C><V><K><G><F><S><K><F><A><N><L><N><K><C><K><I><S><H><T><G><E><K><P><F><K><C><K><E><C><G><N><V><S><C><M><S><L><I><M><T><Q><Q><Q><R><I><H><I><G><E><N><P><Y><Q><C><K><K><C><G><K><A><F><N><E><C><S><C><F><T><D><C><K><R><I><H><V><G><E><K><H><C><K><C><E><E><C><N><N><I><F><K><S><C><S><S><L><A><V><V><E><K><N><H><T><E><K><K><T><Y><R><C><E><E><C><G><K><A><F><N><L><C><S><V><L><T><K><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><S><F><K><L><F><P><Y><L><T><Q><H><K><R><I><H><S><R><E><K><P><Y><K><C><E><E><C><G><K><V><F><K><L><L><S><Y><L><T><Q><H><R><R><I><H><T><G><E><K><T><F><R><C><E><E><C><G><K><A><F><N><Q><S><S><H><L><T><E><H><R><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><T><W><F><S><Y><L><I><Q><H><K><R><I><H><T><G><Q><K><P><Y><K><C><E><E><C><G><K><A><F><T><W><F><S><Y><L><T><Q><H><K><R><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><A><F><N><W><F><S><Y><L><T><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><G><Q><S><S><H><L><S><K><H><K><T><I><H><T><R><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><H><S><A><Q><L><A><V><H><E><K><T><H><T>
|
May be involved in transcriptional regulation.<BOP>
|
Q8IW36
|
P35626
|
ARBK2_HUMAN
|
G-protein-coupled receptor kinase 3
|
Homo
|
<M><A><D><L><E><A><V><L><A><D><V><S><Y><L><M><A><M><E><K><S><K><A><T><P><A><A><R><A><S><K><R><I><V><L><P><E><P><S><I><R><S><V><M><Q><K><Y><L><A><E><R><N><E><I><T><F><D><K><I><F><N><Q><K><I><G><F><L><L><F><K><D><F><C><L><N><E><I><N><E><A><V><P><Q><V><K><F><Y><E><E><I><K><E><Y><E><K><L><D><N><E><E><D><R><L><C><R><S><R><Q><I><Y><D><A><Y><I><M><K><E><L><L><S><C><S><H><P><F><S><K><Q><A><V><E><H><V><Q><S><H><L><S><K><K><Q><V><T><S><T><L><F><Q><P><Y><I><E><E><I><C><E><S><L><R><G><D><I><F><Q><K><F><M><E><S><D><K><F><T><R><F><C><Q><W><K><N><V><E><L><N><I><H><L><T><M><N><E><F><S><V><H><R><I><I><G><R><G><G><F><G><E><V><Y><G><C><R><K><A><D><T><G><K><M><Y><A><M><K><C><L><D><K><K><R><I><K><M><K><Q><G><E><T><L><A><L><N><E><R><I><M><L><S><L><V><S><T><G><D><C><P><F><I><V><C><M><T><Y><A><F><H><T><P><D><K><L><C><F><I><L><D><L><M><N><G><G><D><L><H><Y><H><L><S><Q><H><G><V><F><S><E><K><E><M><R><F><Y><A><T><E><I><I><L><G><L><E><H><M><H><N><R><F><V><V><Y><R><D><L><K><P><A><N><I><L><L><D><E><H><G><H><A><R><I><S><D><L><G><L><A><C><D><F><S><K><K><K><P><H><A><S><V><G><T><H><G><Y><M><A><P><E><V><L><Q><K><G><T><A><Y><D><S><S><A><D><W><F><S><L><G><C><M><L><F><K><L><L><R><G><H><S><P><F><R><Q><H><K><T><K><D><K><H><E><I><D><R><M><T><L><T><V><N><V><E><L><P><D><T><F><S><P><E><L><K><S><L><L><E><G><L><L><Q><R><D><V><S><K><R><L><G><C><H><G><G><G><S><Q><E><V><K><E><H><S><F><F><K><G><V><D><W><Q><H><V><Y><L><Q><K><Y><P><P><P><L><I><P><P><R><G><E><V><N><A><A><D><A><F><D><I><G><S><F><D><E><E><D><T><K><G><I><K><L><L><D><C><D><Q><E><L><Y><K><N><F><P><L><V><I><S><E><R><W><Q><Q><E><V><T><E><T><V><Y><E><A><V><N><A><D><T><D><K><I><E><A><R><K><R><A><K><N><K><Q><L><G><H><E><E><D><Y><A><L><G><K><D><C><I><M><H><G><Y><M><L><K><L><G><N><P><F><L><T><Q><W><Q><R><R><Y><F><Y><L><F><P><N><R><L><E><W><R><G><E><G><E><S><R><Q><N><L><L><T><M><E><Q><I><L><S><V><E><E><T><Q><I><K><D><K><K><C><I><L><F><R><I><K><G><G><K><Q><F><V><L><Q><C><E><S><D><P><E><F><V><Q><W><K><K><E><L><N><E><T><F><K><E><A><Q><R><L><L><R><R><A><P><K><F><L><N><K><P><R><S><G><T><V><E><L><P><K><P><S><L><C><H><R><N><S><N><G><L>
|
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.<BOP>
|
P35626
|
Q6NSZ9
|
ZSC25_HUMAN
|
Zinc finger protein 498
|
Homo
|
<M><L><K><E><H><P><E><M><A><E><A><P><Q><Q><Q><L><G><I><P><V><V><K><L><E><K><E><L><P><W><G><R><G><R><E><D><P><S><P><E><T><F><R><L><R><F><R><Q><F><R><Y><Q><E><A><A><G><P><Q><E><A><L><R><E><L><Q><E><L><C><R><R><W><L><R><P><E><L><H><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><R><E><F><Y><A><W><I><R><E><H><G><P><E><S><G><K><A><L><A><A><M><V><E><D><L><T><E><R><A><L><E><A><K><A><V><P><C><H><R><Q><G><E><Q><E><E><T><A><L><C><R><G><A><W><E><P><G><I><Q><L><G><P><V><E><V><K><P><E><W><G><M><P><P><G><E><G><V><Q><G><P><D><P><G><T><E><E><Q><L><S><Q><D><P><G><D><E><T><R><A><F><Q><E><Q><A><L><P><V><L><Q><A><G><P><G><L><P><A><V><N><P><R><D><Q><E><M><A><A><G><F><F><T><A><G><S><Q><G><L><G><P><F><K><D><M><A><L><A><F><P><E><E><E><W><R><H><V><T><P><A><Q><I><D><C><F><G><E><Y><V><E><P><Q><D><C><R><V><S><P><G><G><G><S><K><E><K><E><A><K><P><P><Q><E><D><L><K><G><A><L><V><A><L><T><S><E><R><F><G><E><A><S><L><Q><G><P><G><L><G><R><V><C><E><Q><E><P><G><G><P><A><G><S><A><P><G><L><P><P><P><Q><H><G><A><I><P><L><P><D><E><V><K><T><H><S><S><F><W><K><P><F><Q><C><P><E><C><G><K><G><F><S><R><S><S><N><L><V><R><H><Q><R><T><H><E><E><K><S><Y><G><C><V><E><C><G><K><G><F><T><L><R><E><Y><L><M><K><H><Q><R><T><H><L><G><K><R><P><Y><V><C><S><E><C><W><K><T><F><S><Q><R><H><H><L><E><V><H><Q><R><S><H><T><G><E><K><P><Y><K><C><G><D><C><W><K><S><F><S><R><R><Q><H><L><Q><V><H><R><R><T><H><T><G><E><K><P><Y><T><C><E><C><G><K><S><F><S><R><N><A><N><L><A><V><H><R><R><A><H><T><G><E><K><P><Y><G><C><Q><V><C><G><K><R><F><S><K><G><E><R><L><V><R><H><Q><R><I><H><T><G><E><K><P><Y><H><C><P><A><C><G><R><S><F><N><Q><R><S><I><L><N><R><H><Q><K><T><Q><H><R><Q><E><P><L><V><Q>
|
May be involved in transcriptional regulation.<BOP>
|
Q6NSZ9
|
Q9NZT2
|
OGFR_HUMAN
|
Zeta-type opioid receptor
|
Homo
|
<M><D><D><P><D><C><D><S><T><W><E><E><D><E><E><D><A><E><D><A><E><D><E><D><C><E><D><G><E><A><A><G><A><R><D><A><D><A><G><D><E><D><E><E><S><E><E><P><R><A><A><R><P><S><S><F><Q><S><R><M><T><G><S><R><N><W><R><A><T><R><D><M><C><R><Y><R><H><N><Y><P><D><L><V><E><R><D><C><N><G><D><T><P><N><L><S><F><Y><R><N><E><I><R><F><L><P><N><G><C><F><I><E><D><I><L><Q><N><W><T><D><N><Y><D><L><L><E><D><N><H><S><Y><I><Q><W><L><F><P><L><R><E><P><G><V><N><W><H><A><K><P><L><T><L><R><E><V><E><V><F><K><S><S><Q><E><I><Q><E><R><L><V><R><A><Y><E><L><M><L><G><F><Y><G><I><R><L><E><D><R><G><T><G><T><V><G><R><A><Q><N><Y><Q><K><R><F><Q><N><L><N><W><R><S><H><N><N><L><R><I><T><R><I><L><K><S><L><G><E><L><G><L><E><H><F><Q><A><P><L><V><R><F><F><L><E><E><T><L><V><R><R><E><L><P><G><V><R><Q><S><A><L><D><Y><F><M><F><A><V><R><C><R><H><Q><R><R><Q><L><V><H><F><A><W><E><H><F><R><P><R><C><K><F><V><W><G><P><Q><D><K><L><R><R><F><K><P><S><S><L><P><H><P><L><E><G><S><R><K><V><E><E><E><G><S><P><G><D><P><D><H><E><A><S><T><Q><G><R><T><C><G><P><E><H><S><K><G><G><G><R><V><D><E><G><P><Q><P><R><S><V><E><P><Q><D><A><G><P><L><E><R><S><Q><G><D><E><A><G><G><H><G><E><D><R><P><E><P><L><S><P><K><E><S><K><K><R><K><L><E><L><S><R><R><E><Q><P><P><T><E><P><G><P><Q><S><A><S><E><V><E><K><I><A><L><N><L><E><G><C><A><L><S><Q><G><S><L><R><T><G><T><Q><E><V><G><G><Q><D><P><G><E><A><V><Q><P><C><R><Q><P><L><G><A><R><V><A><D><K><V><R><K><R><R><K><V><D><E><G><A><G><D><S><A><A><V><A><S><G><G><A><Q><T><L><A><L><A><G><S><P><A><P><S><G><H><P><K><A><G><H><S><E><N><G><V><E><E><D><T><E><G><R><T><G><P><K><E><G><T><P><G><S><P><S><E><T><P><G><P><S><P><A><G><P><A><G><D><E><P><A><E><S><P><S><E><T><P><G><P><R><P><A><G><P><A><G><D><E><P><A><E><S><P><S><E><T><P><G><P><R><P><A><G><P><A><G><D><E><P><A><E><S><P><S><E><T><P><G><P><S><P><A><G><P><T><R><D><E><P><A><E><S><P><S><E><T><P><G><P><R><P><A><G><P><A><G><D><E><P><A><E><S><P><S><E><T><P><G><P><R><P><A><G><P><A><G><D><E><P><A><E><S><P><S><E><T><P><G><P><S><P><A><G><P><T><R><D><E><P><A><K><A><G><E><A><A><E><L><Q><D><A><E><V><E><S><S><A><K><S><G><K><P>
|
Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.<BOP>
|
Q9NZT2
|
P16233
|
LIPP_HUMAN
|
Pancreatic triacylglycerol lipase
|
Homo
|
<M><L><P><L><W><T><L><S><L><L><L><G><A><V><A><G><K><E><V><C><Y><E><R><L><G><C><F><S><D><D><S><P><W><S><G><I><T><E><R><P><L><H><I><L><P><W><S><P><K><D><V><N><T><R><F><L><L><Y><T><N><E><N><P><N><N><F><Q><E><V><A><A><D><S><S><S><I><S><G><S><N><F><K><T><N><R><K><T><R><F><I><I><H><G><F><I><D><K><G><E><E><N><W><L><A><N><V><C><K><N><L><F><K><V><E><S><V><N><C><I><C><V><D><W><K><G><G><S><R><T><G><Y><T><Q><A><S><Q><N><I><R><I><V><G><A><E><V><A><Y><F><V><E><F><L><Q><S><A><F><G><Y><S><P><S><N><V><H><V><I><G><H><S><L><G><A><H><A><A><G><E><A><G><R><R><T><N><G><T><I><G><R><I><T><G><L><D><P><A><E><P><C><F><Q><G><T><P><E><L><V><R><L><D><P><S><D><A><K><F><V><D><V><I><H><T><D><G><A><P><I><V><P><N><L><G><F><G><M><S><Q><V><V><G><H><L><D><F><F><P><N><G><G><V><E><M><P><G><C><K><K><N><I><L><S><Q><I><V><D><I><D><G><I><W><E><G><T><R><D><F><A><A><C><N><H><L><R><S><Y><K><Y><Y><T><D><S><I><V><N><P><D><G><F><A><G><F><P><C><A><S><Y><N><V><F><T><A><N><K><C><F><P><C><P><S><G><G><C><P><Q><M><G><H><Y><A><D><R><Y><P><G><K><T><N><D><V><G><Q><K><F><Y><L><D><T><G><D><A><S><N><F><A><R><W><R><Y><K><V><S><V><T><L><S><G><K><K><V><T><G><H><I><L><V><S><L><F><G><N><K><G><N><S><K><Q><Y><E><I><F><K><G><T><L><K><P><D><S><T><H><S><N><E><F><D><S><D><V><D><V><G><D><L><Q><M><V><K><F><I><W><Y><N><N><V><I><N><P><T><L><P><R><V><G><A><S><K><I><I><V><E><T><N><V><G><K><Q><F><N><F><C><S><P><E><T><V><R><E><E><V><L><L><T><L><T><P><C>
|
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.<BOP>
|
P16233
|
P31269
|
HXA9_HUMAN
|
Homeobox protein Hox-1G
|
Homo
|
<M><A><T><T><G><A><L><G><N><Y><Y><V><D><S><F><L><L><G><A><D><A><A><D><E><L><S><V><G><R><Y><A><P><G><T><L><G><Q><P><P><R><Q><A><A><T><L><A><E><H><P><D><F><S><P><C><S><F><Q><S><K><A><T><V><F><G><A><S><W><N><P><V><H><A><A><G><A><N><A><V><P><A><A><V><Y><H><H><H><H><H><H><P><Y><V><H><P><Q><A><P><V><A><A><A><A><P><D><G><R><Y><M><R><S><W><L><E><P><T><P><G><A><L><S><F><A><G><L><P><S><S><R><P><Y><G><I><K><P><E><P><L><S><A><R><R><G><D><C><P><T><L><D><T><H><T><L><S><L><T><D><Y><A><C><G><S><P><P><V><D><R><E><K><Q><P><S><E><G><A><F><S><E><N><N><A><E><N><E><S><G><G><D><K><P><P><I><D><P><N><N><P><A><A><N><W><L><H><A><R><S><T><R><K><K><R><C><P><Y><T><K><H><Q><T><L><E><L><E><K><E><F><L><F><N><M><Y><L><T><R><D><R><R><Y><E><V><A><R><L><L><N><L><T><E><R><Q><V><K><I><W><F><Q><N><R><R><M><K><M><K><K><I><N><K><D><R><A><K><D><E>
|
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.<BOP>
|
P31269
|
A6NH57
|
ARL5C_HUMAN
|
ADP-ribosylation factor-like protein 12
|
Homo
|
<M><G><Q><L><I><A><K><L><M><S><I><F><G><N><Q><E><H><T><V><I><I><V><G><L><D><N><E><G><K><T><T><I><L><Y><R><F><L><T><N><E><V><V><H><M><C><P><T><I><G><S><N><V><E><E><I><I><L><P><K><T><H><F><F><M><W><D><I><V><R><P><E><A><L><S><F><I><W><N><T><Y><Y><S><N><T><E><F><I><I><L><V><I><D><S><T><D><R><D><R><L><L><T><T><R><E><E><L><Y><K><M><L><A><H><E><A><L><Q><D><A><S><V><L><I><F><A><N><K><Q><D><V><K><D><S><M><R><M><V><E><I><S><H><F><L><T><L><S><T><I><K><D><H><S><W><H><I><Q><G><C><C><A><L><T><R><E><G><L><P><A><R><L><Q><W><M><E><S><Q><A><A><A><N>
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Binds and exchanges GTP and GDP.<BOP>
|
A6NH57
|
Q9GZU7
|
CTDS1_HUMAN
|
Small C-terminal domain phosphatase 1
|
Homo
|
<M><D><S><S><A><V><I><T><Q><I><S><K><E><E><A><R><G><P><L><R><G><K><G><D><Q><K><S><A><A><S><Q><K><P><R><S><R><G><I><L><H><S><L><F><C><C><V><C><R><D><D><G><E><A><L><P><A><H><S><G><A><P><L><L><V><E><E><N><G><A><I><P><K><Q><T><P><V><Q><Y><L><L><P><E><A><K><A><Q><D><S><D><K><I><C><V><V><I><D><L><D><E><T><L><V><H><S><S><F><K><P><V><N><N><A><D><F><I><I><P><V><E><I><D><G><V><V><H><Q><V><Y><V><L><K><R><P><H><V><D><E><F><L><Q><R><M><G><E><L><F><E><C><V><L><F><T><A><S><L><A><K><Y><A><D><P><V><A><D><L><L><D><K><W><G><A><F><R><A><R><L><F><R><E><S><C><V><F><H><R><G><N><Y><V><K><D><L><S><R><L><G><R><D><L><R><R><V><L><I><L><D><N><S><P><A><S><Y><V><F><H><P><D><N><A><V><P><V><A><S><W><F><D><N><M><S><D><T><E><L><H><D><L><L><P><F><F><E><Q><L><S><R><V><D><D><V><Y><S><V><L><R><Q><P><R><P><G><S>
|
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<BOP>
|
Q9GZU7
|
A0A0J9YXG5
|
TJB14_HUMAN
|
T cell receptor beta joining 1-4
|
Homo
|
<T><N><E><K><L><F><F><G><S><G><T><Q><L><S><V><L>
|
J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
|
A0A0J9YXG5
|
O95838
|
GLP2R_HUMAN
|
Glucagon-like peptide 2 receptor
|
Homo
|
<M><K><L><G><S><S><R><A><G><P><G><R><G><S><A><G><L><L><P><G><V><H><E><L><P><M><G><I><P><A><P><W><G><T><S><P><L><S><F><H><R><K><C><S><L><W><A><P><G><R><P><F><L><T><L><V><L><L><V><S><I><K><Q><V><T><G><S><L><L><E><E><T><T><R><K><W><A><Q><Y><K><Q><A><C><L><R><D><L><L><K><E><P><S><G><I><F><C><N><G><T><F><D><Q><Y><V><C><W><P><H><S><S><P><G><N><V><S><V><P><C><P><S><Y><L><P><W><W><S><E><E><S><S><G><R><A><Y><R><H><C><L><A><Q><G><T><W><Q><T><I><E><N><A><T><D><I><W><Q><D><D><S><E><C><S><E><N><H><S><F><K><Q><N><V><D><R><Y><A><L><L><S><T><L><Q><L><M><Y><T><V><G><Y><S><F><S><L><I><S><L><F><L><A><L><T><L><L><L><F><L><R><K><L><H><C><T><R><N><Y><I><H><M><N><L><F><A><S><F><I><L><R><T><L><A><V><L><V><K><D><V><V><F><Y><N><S><Y><S><K><R><P><D><N><E><N><G><W><M><S><Y><L><S><E><M><S><T><S><C><R><S><V><Q><V><L><L><H><Y><F><V><G><A><N><Y><L><W><L><L><V><E><G><L><Y><L><H><T><L><L><E><P><T><V><L><P><E><R><R><L><W><P><R><Y><L><L><L><G><W><A><F><P><V><L><F><V><V><P><W><G><F><A><R><A><H><L><E><N><T><G><C><W><T><T><N><G><N><K><K><I><W><W><I><I><R><G><P><M><M><L><C><V><T><V><N><F><F><I><F><L><K><I><L><K><L><L><I><S><K><L><K><A><H><Q><M><C><F><R><D><Y><K><Y><R><L><A><K><S><T><L><V><L><I><P><L><L><G><V><H><E><I><L><F><S><F><I><T><D><D><Q><V><E><G><F><A><K><L><I><R><L><F><I><Q><L><T><L><S><S><F><H><G><F><L><V><A><L><Q><Y><G><F><A><N><G><E><V><K><A><E><L><R><K><Y><W><V><R><F><L><L><A><R><H><S><G><C><R><A><C><V><L><G><K><D><F><R><F><L><G><K><C><P><K><K><L><S><E><G><D><G><A><E><K><L><R><K><L><Q><P><S><L><N><S><G><R><L><L><H><L><A><M><R><G><L><G><E><L><G><A><Q><P><Q><Q><D><H><A><R><W><P><R><G><S><S><L><S><E><C><S><E><G><D><V><T><M><A><N><T><M><E><E><I><L><E><E><S><E><I>
|
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<BOP>
|
O95838
|
Q13278
|
RIG_HUMAN
|
Protein regulated in glioma
|
Homo
|
<M><P><F><F><S><S><C><L><C><P><S><H><Y><S><G><P><S><L><P><S><S><T><S><S><S><L><P><T><G><P><E><N><Q><L><G><F><V><L><L><Q><A><M><V><H><H><A><N><S><S><C><V><R><N><A><F><W><L><Q><I><T><E><K><L><T><P><A><L><S><I><I><I><S><V><V><Y><L><R><C><P><E><M><V><E><N><R><I><G><F><L><L><N><V><K><D><S><K><T><L><S><V><V><G><P><H><P><K><P><C><I><L>
|
May serve as a molecular marker for or play a role in the malignant progression of glioblastomas.<BOP>
|
Q13278
|
P28356
|
HXD9_HUMAN
|
Homeobox protein Hox-5.2
|
Homo
|
<M><L><G><G><S><A><G><R><L><K><M><S><S><S><G><T><L><S><N><Y><Y><V><D><S><L><I><G><H><E><G><D><E><V><F><A><A><R><F><G><P><P><G><P><G><A><Q><G><R><P><A><G><V><A><D><G><P><A><A><T><A><A><E><F><A><S><C><S><F><A><P><R><S><A><V><F><S><A><S><W><S><A><V><P><S><Q><P><P><A><A><A><A><M><S><G><L><Y><H><P><Y><V><P><P><P><P><L><A><A><S><A><S><E><P><G><R><Y><V><R><S><W><M><E><P><L><P><G><F><P><G><G><A><G><G><G><G><G><G><G><G><G><G><P><G><R><G><P><S><P><G><P><S><G><P><A><N><G><R><H><Y><G><I><K><P><E><T><R><A><A><P><A><P><A><T><A><A><S><T><T><S><S><S><S><T><S><L><S><S><S><S><K><R><T><E><C><S><V><A><R><E><S><Q><G><S><S><G><P><E><F><S><C><N><S><F><L><Q><E><K><A><A><A><A><T><G><G><T><G><P><G><A><G><I><G><A><A><T><G><T><G><G><S><S><E><P><S><A><C><S><D><H><P><I><P><G><C><S><L><K><E><E><E><K><Q><H><S><Q><P><Q><Q><Q><Q><L><D><P><N><N><P><A><A><N><W><I><H><A><R><S><T><R><K><K><R><C><P><Y><T><K><Y><Q><T><L><E><L><E><K><E><F><L><F><N><M><Y><L><T><R><D><R><R><Y><E><V><A><R><I><L><N><L><T><E><R><Q><V><K><I><W><F><Q><N><R><R><M><K><M><K><K><M><S><K><E><K><C><P><K><G><D>
|
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
|
P28356
|
P81534
|
D103A_HUMAN
|
Defensin-like protein
|
Homo
|
<M><R><I><H><Y><L><L><F><A><L><L><F><L><F><L><V><P><V><P><G><H><G><G><I><I><N><T><L><Q><K><Y><Y><C><R><V><R><G><G><R><C><A><V><L><S><C><L><P><K><E><E><Q><I><G><K><C><S><T><R><G><R><K><C><C><R><R><K><K>
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Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.<BOP>
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P81534
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Q30KP8
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DB136_HUMAN
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DEFB137
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Homo
|
<M><N><L><C><L><S><A><L><L><F><F><L><V><I><L><L><P><S><G><K><G><M><F><G><N><D><G><V><K><V><R><T><C><T><S><Q><K><A><V><C><F><F><G><C><P><P><G><Y><R><W><I><A><F><C><H><N><I><L><S><C><C><K><N><M><T><R><F><Q><P><P><Q><A><K><D><P><W><V><H>
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Host defense peptide that exhibits antibacterial and antifungal activity . Exhibits antimicrobial activity against E.coli, S.aureus and C.albicans (in vitro) . Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be involved in immunoregulation through LPS neutralization .<BOP>
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Q30KP8
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O00481
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BT3A1_HUMAN
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Butyrophilin subfamily 3 member A1
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Homo
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<M><K><M><A><S><F><L><A><F><L><L><L><N><F><R><V><C><L><L><L><L><Q><L><L><M><P><H><S><A><Q><F><S><V><L><G><P><S><G><P><I><L><A><M><V><G><E><D><A><D><L><P><C><H><L><F><P><T><M><S><A><E><T><M><E><L><K><W><V><S><S><S><L><R><Q><V><V><N><V><Y><A><D><G><K><E><V><E><D><R><Q><S><A><P><Y><R><G><R><T><S><I><L><R><D><G><I><T><A><G><K><A><A><L><R><I><H><N><V><T><A><S><D><S><G><K><Y><L><C><Y><F><Q><D><G><D><F><Y><E><K><A><L><V><E><L><K><V><A><A><L><G><S><D><L><H><V><D><V><K><G><Y><K><D><G><G><I><H><L><E><C><R><S><T><G><W><Y><P><Q><P><Q><I><Q><W><S><N><N><K><G><E><N><I><P><T><V><E><A><P><V><V><A><D><G><V><G><L><Y><A><V><A><A><S><V><I><M><R><G><S><S><G><E><G><V><S><C><T><I><R><S><S><L><L><G><L><E><K><T><A><S><I><S><I><A><D><P><F><F><R><S><A><Q><R><W><I><A><A><L><A><G><T><L><P><V><L><L><L><L><L><G><G><A><G><Y><F><L><W><Q><Q><Q><E><E><K><K><T><Q><F><R><K><K><K><R><E><Q><E><L><R><E><M><A><W><S><T><M><K><Q><E><Q><S><T><R><V><K><L><L><E><E><L><R><W><R><S><I><Q><Y><A><S><R><G><E><R><H><S><A><Y><N><E><W><K><K><A><L><F><K><P><A><D><V><I><L><D><P><K><T><A><N><P><I><L><L><V><S><E><D><Q><R><S><V><Q><R><A><K><E><P><Q><D><L><P><D><N><P><E><R><F><N><W><H><Y><C><V><L><G><C><E><S><F><I><S><G><R><H><Y><W><E><V><E><V><G><D><R><K><E><W><H><I><G><V><C><S><K><N><V><Q><R><K><G><W><V><K><M><T><P><E><N><G><F><W><T><M><G><L><T><D><G><N><K><Y><R><T><L><T><E><P><R><T><N><L><K><L><P><K><P><P><K><K><V><G><V><F><L><D><Y><E><T><G><D><I><S><F><Y><N><A><V><D><G><S><H><I><H><T><F><L><D><V><S><F><S><E><A><L><Y><P><V><F><R><I><L><T><L><E><P><T><A><L><T><I><C><P><A>
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Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.<BOP>
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O00481
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Q00973
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B4GN1_HUMAN
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GalNAc-T
|
Homo
|
<M><W><L><G><R><R><A><L><C><A><L><V><L><L><L><A><C><A><S><L><G><L><L><Y><A><S><T><R><D><A><P><G><L><R><L><P><L><A><P><W><A><P><P><Q><S><P><R><R><P><E><L><P><D><L><A><P><E><P><R><Y><A><H><I><P><V><R><I><K><E><Q><V><V><G><L><L><A><W><N><N><C><S><C><E><S><S><G><G><G><L><P><L><P><F><Q><K><Q><V><R><A><I><D><L><T><K><A><F><D><P><A><E><L><R><A><A><S><A><T><R><E><Q><E><F><Q><A><F><L><S><R><S><Q><S><P><A><D><Q><L><L><I><A><P><A><N><S><P><L><Q><Y><P><L><Q><G><V><E><V><Q><P><L><R><S><I><L><V><P><G><L><S><L><Q><A><A><S><G><Q><E><V><Y><Q><V><N><L><T><A><S><L><G><T><W><D><V><A><G><E><V><T><G><V><T><L><T><G><E><G><Q><A><D><L><T><L><V><S><P><G><L><D><Q><L><N><R><Q><L><Q><L><V><T><Y><S><S><R><S><Y><Q><T><N><T><A><D><T><V><R><F><S><T><E><G><H><E><A><A><F><T><I><R><I><R><H><P><P><N><P><R><L><Y><P><P><G><S><L><P><Q><G><A><Q><Y><N><I><S><A><L><V><T><I><A><T><K><T><F><L><R><Y><D><R><L><R><A><L><I><T><S><I><R><R><F><Y><P><T><V><T><V><V><I><A><D><D><S><D><K><P><E><R><V><S><G><P><Y><V><E><H><Y><L><M><P><F><G><K><G><W><F><A><G><R><N><L><A><V><S><Q><V><T><T><K><Y><V><L><W><V><D><D><D><F><V><F><T><A><R><T><R><L><E><R><L><V><D><V><L><E><R><T><P><L><D><L><V><G><G><A><V><R><E><I><S><G><F><A><T><T><Y><R><Q><L><L><S><V><E><P><G><A><P><G><L><G><N><C><L><R><Q><R><R><G><F><H><H><E><L><V><G><F><P><G><C><V><V><T><D><G><V><V><N><F><F><L><A><R><T><D><K><V><R><E><V><G><F><D><P><R><L><S><R><V><A><H><L><E><F><F><L><D><G><L><G><S><L><R><V><G><S><C><S><D><V><V><V><D><H><A><S><K><L><K><L><P><W><T><S><R><D><A><G><A><E><T><Y><A><R><Y><R><Y><P><G><S><L><D><E><S><Q><M><A><K><H><R><L><L><F><F><K><H><R><L><Q><C><M><T><S><Q>
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Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively.<BOP>
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Q00973
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P01732
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CD8A_HUMAN
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T-lymphocyte differentiation antigen T8/Leu-2
|
Homo
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<M><A><L><P><V><T><A><L><L><L><P><L><A><L><L><L><H><A><A><R><P><S><Q><F><R><V><S><P><L><D><R><T><W><N><L><G><E><T><V><E><L><K><C><Q><V><L><L><S><N><P><T><S><G><C><S><W><L><F><Q><P><R><G><A><A><A><S><P><T><F><L><L><Y><L><S><Q><N><K><P><K><A><A><E><G><L><D><T><Q><R><F><S><G><K><R><L><G><D><T><F><V><L><T><L><S><D><F><R><R><E><N><E><G><Y><Y><F><C><S><A><L><S><N><S><I><M><Y><F><S><H><F><V><P><V><F><L><P><A><K><P><T><T><T><P><A><P><R><P><P><T><P><A><P><T><I><A><S><Q><P><L><S><L><R><P><E><A><C><R><P><A><A><G><G><A><V><H><T><R><G><L><D><F><A><C><D><I><Y><I><W><A><P><L><A><G><T><C><G><V><L><L><L><S><L><V><I><T><L><Y><C><N><H><R><N><R><R><R><V><C><K><C><P><R><P><V><V><K><S><G><D><K><P><S><L><S><A><R><Y><V>
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Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.<BOP>
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P01732
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P52744
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ZN138_HUMAN
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Zinc finger protein 138
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Homo
|
<M><K><R><H><E><M><V><V><A><K><H><S><A><L><C><S><R><F><A><Q><D><L><W><L><E><Q><N><I><K><D><S><F><Q><K><V><T><L><S><R><Y><G><K><Y><G><H><K><N><L><Q><L><R><K><G><C><K><S><V><D><E><C><K><G><H><Q><G><G><F><N><G><L><N><Q><C><L><K><I><T><T><S><K><I><F><Q><C><N><K><Y><V><K><V><M><H><K><F><S><N><S><N><R><H><K><I><R><H><T><E><N><K><H><F><R><C><K><E><C><D><K><S><L><C><M><L><S><R><L><T><Q><H><K><K><I><H><T><R><E><N><F><Y><K><C><E><E><C><G><K><T><F><N><W><S><T><N><L><S><K><P><K><K><I><H><T><G><E><K><P><Y><K><C><E><V><C><G><K><A><F><H><Q><S><S><I><L><T><K><H><K><I><I><R><T><G><E><K><P><Y><K><C><A><H><C><G><K><A><F><K><Q><S><S><H><L><T><R><H><K><I><I><H><T><E><E><K><P><Y><K><C><E><Q><C><G><K><V><F><K><Q><S><P><T><L><T><K><H><Q><I><I><Y><T><G><E><E><P><Y><K><C><E><E><C><G><K><A><F><N><L><S>
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May be involved in transcriptional regulation as a repressor.<BOP>
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P52744
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Q96CB8
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INT12_HUMAN
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PHD finger protein 22
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Homo
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<M><A><A><T><V><N><L><E><L><D><P><I><F><L><K><A><L><G><F><L><H><S><K><S><K><D><S><A><E><K><L><K><A><L><L><D><E><S><L><A><R><G><I><D><S><S><Y><R><P><S><Q><K><D><V><E><P><P><K><I><S><S><T><K><N><I><S><I><K><Q><E><P><K><I><S><S><S><L><P><S><G><N><N><N><G><K><V><L><T><T><E><K><V><K><K><E><A><E><K><R><P><A><D><K><M><K><S><D><I><T><E><G><V><D><I><P><K><K><P><R><L><E><K><P><E><T><Q><S><S><P><I><T><V><Q><S><S><K><D><L><P><M><A><D><L><S><S><F><E><E><T><S><A><D><D><F><A><M><E><M><G><L><A><C><V><V><C><R><Q><M><M><V><A><S><G><N><Q><L><V><E><C><Q><E><C><H><N><L><Y><H><R><D><C><H><K><P><Q><V><T><D><K><E><A><N><D><P><R><L><V><W><Y><C><A><R><C><T><R><Q><M><K><R><M><A><Q><K><T><Q><K><P><P><Q><K><P><A><P><A><V><V><S><V><T><P><A><V><K><D><P><L><V><K><K><P><E><T><K><L><K><Q><E><T><T><F><L><A><F><K><R><T><E><V><K><T><S><T><V><I><S><G><N><S><S><S><A><S><V><S><S><S><V><T><S><G><L><T><G><W><A><A><F><A><A><K><T><S><S><A><G><P><S><T><A><K><L><S><S><T><T><Q><N><N><T><G><K><P><A><T><S><S><A><N><Q><K><P><V><G><L><T><G><L><A><T><S><S><K><G><G><I><G><S><K><I><G><S><N><N><S><T><T><P><T><V><P><L><K><P><P><P><P><L><T><L><G><K><T><G><L><S><R><S><V><S><C><D><N><V><S><K><V><G><L><P><S><P><S><S><L><V><P><G><S><S><S><Q><L><S><G><N><G><N><S><G><T><S><G><P><S><G><S><T><T><S><K><T><T><S><E><S><S><S><S><P><S><A><S><L><K><G><P><T><S><Q><E><S><Q><L><N><A><M><K><R><L><Q><M><V><K><K><K><A><A><Q><K><K><L><K><K>
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Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes . Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex .<BOP>
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Q96CB8
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Q96AE4
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FUBP1_HUMAN
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DNA helicase V
|
Homo
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<M><A><D><Y><S><T><V><P><P><P><S><S><G><S><A><G><G><G><G><G><G><G><G><G><G><G><V><N><D><A><F><K><D><A><L><Q><R><A><R><Q><I><A><A><K><I><G><G><D><A><G><T><S><L><N><S><N><D><Y><G><Y><G><G><Q><K><R><P><L><E><D><G><D><Q><P><D><A><K><K><V><A><P><Q><N><D><S><F><G><T><Q><L><P><P><M><H><Q><Q><Q><S><R><S><V><M><T><E><E><Y><K><V><P><D><G><M><V><G><F><I><I><G><R><G><G><E><Q><I><S><R><I><Q><Q><E><S><G><C><K><I><Q><I><A><P><D><S><G><G><L><P><E><R><S><C><M><L><T><G><T><P><E><S><V><Q><S><A><K><R><L><L><D><Q><I><V><E><K><G><R><P><A><P><G><F><H><H><G><D><G><P><G><N><A><V><Q><E><I><M><I><P><A><S><K><A><G><L><V><I><G><K><G><G><E><T><I><K><Q><L><Q><E><R><A><G><V><K><M><V><M><I><Q><D><G><P><Q><N><T><G><A><D><K><P><L><R><I><T><G><D><P><Y><K><V><Q><Q><A><K><E><M><V><L><E><L><I><R><D><Q><G><G><F><R><E><V><R><N><E><Y><G><S><R><I><G><G><N><E><G><I><D><V><P><I><P><R><F><A><V><G><I><V><I><G><R><N><G><E><M><I><K><K><I><Q><N><D><A><G><V><R><I><Q><F><K><P><D><D><G><T><T><P><E><R><I><A><Q><I><T><G><P><P><D><R><C><Q><H><A><A><E><I><I><T><D><L><L><R><S><V><Q><A><G><N><P><G><G><P><G><P><G><G><R><G><R><G><R><G><Q><G><N><W><N><M><G><P><P><G><G><L><Q><E><F><N><F><I><V><P><T><G><K><T><G><L><I><I><G><K><G><G><E><T><I><K><S><I><S><Q><Q><S><G><A><R><I><E><L><Q><R><N><P><P><P><N><A><D><P><N><M><K><L><F><T><I><R><G><T><P><Q><Q><I><D><Y><A><R><Q><L><I><E><E><K><I><G><G><P><V><N><P><L><G><P><P><V><P><H><G><P><H><G><V><P><G><P><H><G><P><P><G><P><P><G><P><G><T><P><M><G><P><Y><N><P><A><P><Y><N><P><G><P><P><G><P><A><P><H><G><P><P><A><P><Y><A><P><Q><G><W><G><N><A><Y><P><H><W><Q><Q><Q><A><P><P><D><P><A><K><A><G><T><D><P><N><S><A><A><W><A><A><Y><Y><A><H><Y><Y><Q><Q><Q><A><Q><P><P><P><A><A><P><A><G><A><P><T><T><T><Q><T><N><G><Q><G><D><Q><Q><N><P><A><P><A><G><Q><V><D><Y><T><K><A><W><E><E><Y><Y><K><K><M><G><Q><A><V><P><A><P><T><G><A><P><P><G><G><Q><P><D><Y><S><A><A><W><A><E><Y><Y><R><Q><Q><A><A><Y><Y><A><Q><T><S><P><Q><G><M><P><Q><H><P><P><A><P><Q><G><Q>
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Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.<BOP>
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Q96AE4
|
Q9BXI6
|
TB10A_HUMAN
|
Rab27A-GAP-alpha
|
Homo
|
<M><A><K><S><N><G><E><N><G><P><R><A><P><A><A><G><E><S><L><S><G><T><R><E><S><L><A><Q><G><P><D><A><A><T><T><D><E><L><S><S><L><G><S><D><S><E><A><N><G><F><A><E><R><R><I><D><K><F><G><F><I><V><G><S><Q><G><A><E><G><A><L><E><E><V><P><L><E><V><L><R><Q><R><E><S><K><W><L><D><M><L><N><N><W><D><K><W><M><A><K><K><H><K><K><I><R><L><R><C><Q><K><G><I><P><P><S><L><R><G><R><A><W><Q><Y><L><S><G><G><K><V><K><L><Q><Q><N><P><G><K><F><D><E><L><D><M><S><P><G><D><P><K><W><L><D><V><I><E><R><D><L><H><R><Q><F><P><F><H><E><M><F><V><S><R><G><G><H><G><Q><Q><D><L><F><R><V><L><K><A><Y><T><L><Y><R><P><E><E><G><Y><C><Q><A><Q><A><P><I><A><A><V><L><L><M><H><M><P><A><E><Q><A><F><W><C><L><V><Q><I><C><E><K><Y><L><P><G><Y><Y><S><E><K><L><E><A><I><Q><L><D><G><E><I><L><F><S><L><L><Q><K><V><S><P><V><A><H><K><H><L><S><R><Q><K><I><D><P><L><L><Y><M><T><E><W><F><M><C><A><F><S><R><T><L><P><W><S><S><V><L><R><V><W><D><M><F><F><C><E><G><V><K><I><I><F><R><V><G><L><V><L><L><K><H><A><L><G><S><P><E><K><V><K><A><C><Q><G><Q><Y><E><T><I><E><R><L><R><S><L><S><P><K><I><M><Q><E><A><F><L><V><Q><E><V><V><E><L><P><V><T><E><R><Q><I><E><R><E><H><L><I><Q><L><R><R><W><Q><E><T><R><G><E><L><Q><C><R><S><P><P><R><L><H><G><A><K><A><I><L><D><A><E><P><G><P><R><P><A><L><Q><P><S><P><S><I><R><L><P><L><D><A><P><L><P><G><S><K><A><K><P><K><P><P><K><Q><A><Q><K><E><Q><R><K><Q><M><K><G><R><G><Q><L><E><K><P><P><A><P><N><Q><A><M><V><V><A><A><A><G><D><A><C><P><P><Q><H><V><P><P><K><D><S><A><P><K><D><S><A><P><Q><D><L><A><P><Q><V><S><A><H><H><R><S><Q><E><S><L><T><S><Q><E><S><E><D><T><Y><L>
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Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.<BOP>
|
Q9BXI6
|
Q9GZZ8
|
LACRT_HUMAN
|
Extracellular glycoprotein lacritin
|
Homo
|
<M><K><F><T><T><L><L><F><L><A><A><V><A><G><A><L><V><Y><A><E><D><A><S><S><D><S><T><G><A><D><P><A><Q><E><A><G><T><S><K><P><N><E><E><I><S><G><P><A><E><P><A><S><P><P><E><T><T><T><T><A><Q><E><T><S><A><A><A><V><Q><G><T><A><K><V><T><S><S><R><Q><E><L><N><P><L><K><S><I><V><E><K><S><I><L><L><T><E><Q><A><L><A><K><A><G><K><G><M><H><G><G><V><P><G><G><K><Q><F><I><E><N><G><S><E><F><A><Q><K><L><L><K><K><F><S><L><L><K><P><W><A>
|
Modulates secretion by lacrimal acinar cells.<BOP>
|
Q9GZZ8
|
A0A0J9YXY3
|
TVB62_HUMAN
|
T cell receptor beta variable 6-2
|
Homo
|
<M><S><L><G><L><L><C><C><G><A><F><S><L><L><W><A><G><P><V><N><A><G><V><T><Q><T><P><K><F><R><V><L><K><T><G><Q><S><M><T><L><L><C><A><Q><D><M><N><H><E><Y><M><Y><W><Y><R><Q><D><P><G><M><G><L><R><L><I><H><Y><S><V><G><E><G><T><T><A><K><G><E><V><P><D><G><Y><N><V><S><R><L><K><K><Q><N><F><L><L><G><L><E><S><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><Y>
|
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
|
A0A0J9YXY3
|
A6NLC5
|
CC070_HUMAN
|
UPF0524 protein C3orf70
|
Homo
|
<M><S><A><A><A><S><P><A><S><E><R><G><W><K><S><E><K><L><D><E><A><Q><A><L><A><R><S><C><A><A><R><R><P><D><F><Q><P><C><D><G><L><S><I><C><A><T><H><S><H><G><K><C><F><K><L><H><W><C><C><H><L><G><W><C><H><C><K><Y><M><Y><Q><P><M><T><P><V><E><Q><L><P><S><T><E><I><P><A><R><P><R><E><P><T><N><T><I><Q><I><S><V><S><L><T><E><H><F><L><K><F><A><S><V><F><Q><P><P><L><P><P><D><S><P><R><Y><C><M><I><S><D><L><F><I><D><N><Y><Q><V><K><C><I><N><G><K><M><C><Y><V><Q><K><Q><P><A><P><H><S><H><R><M><S><P><E><E><V><S><A><H><D><A><L><I><S><K><E><S><N><T><P><K><I><D><H><C><S><S><P><S><S><S><E><D><S><G><I><N><A><I><G><A><H><Y><V><E><S><C><D><E><D><T><E><E><G><A><E><L><S><S><E><E><D><Y><S><P><E><S><S><W><E><P><D><E><C><T><L><L><S><P><S><Q><S><D><L><E><V><I><E><T><I><E><T><T><V>
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May play a role in neuronal and neurobehavioral development.<BOP>
|
A6NLC5
|
Q15528
|
MED22_HUMAN
|
Surfeit locus protein 5
|
Homo
|
<M><A><Q><Q><R><A><L><P><Q><S><K><E><T><L><L><Q><S><Y><N><K><R><L><K><D><D><I><K><S><I><M><D><N><F><T><E><I><I><K><T><A><K><I><E><D><E><T><Q><V><S><R><A><T><Q><G><E><Q><D><N><Y><E><M><H><V><R><A><A><N><I><V><R><A><G><E><S><L><M><K><L><V><S><D><L><K><Q><F><L><I><L><N><D><F><P><S><V><N><E><A><I><D><Q><R><N><Q><Q><L><R><T><L><Q><E><E><C><D><R><K><L><I><T><L><R><D><E><I><S><I><D><L><Y><E><L><E><E><E><Y><Y><S><S><S><S><S><L><C><E><A><N><D><L><P><L><C><E><A><Y><G><R><L><D><L><D><T><D><S><A><D><G><L><S><A><P><L><L><A><S><P><E><P><S><A><G><P><L><Q><V><A><A><P><A><H><S><H><A><G><G><P><G><P><T><E><H><A>
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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP>
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Q15528
|
Q14990
|
ODFP1_HUMAN
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Heat shock protein beta-10
|
Homo
|
<M><A><A><L><S><C><L><L><D><S><V><R><R><D><I><K><K><V><D><R><E><L><R><Q><L><R><C><I><D><E><F><S><T><R><C><L><C><D><L><Y><M><H><P><Y><C><C><C><D><L><H><P><Y><P><Y><C><L><C><Y><S><K><R><S><R><S><C><G><L><C><D><L><Y><P><C><C><L><C><D><Y><K><L><Y><C><L><R><P><S><L><R><S><L><E><R><K><A><I><R><A><I><E><D><E><K><R><E><L><A><K><L><R><R><T><T><N><R><I><L><A><S><S><C><C><S><S><N><I><L><G><S><V><N><V><C><G><F><E><P><D><Q><V><K><V><R><V><K><D><G><K><V><C><V><S><A><E><R><E><N><R><Y><D><C><L><G><S><K><K><Y><S><Y><M><N><I><C><K><E><F><S><L><P><P><C><V><D><E><K><D><V><T><Y><S><Y><G><L><G><S><C><V><K><I><E><S><P><C><Y><P><C><T><S><P><C><S><P><C><S><P><C><S><P><C><N><P><C><S><P><C><N><P><C><S><P><Y><D><P><C><N><P><C><Y><P><C><G><S><R><F><S><C><R><K><M><I><L>
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Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.<BOP>
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Q14990
|
Q9H3R2
|
MUC13_HUMAN
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Down-regulated in colon cancer 1
|
Homo
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<M><K><A><I><I><H><L><T><L><L><A><L><L><S><V><N><T><A><T><N><Q><G><N><S><A><D><A><V><T><T><T><E><T><A><T><S><G><P><T><V><A><A><A><D><T><T><E><T><N><F><P><E><T><A><S><T><T><A><N><T><P><S><F><P><T><A><T><S><P><A><P><P><I><I><S><T><H><S><S><S><T><I><P><T><P><A><P><P><I><I><S><T><H><S><S><S><T><I><P><I><P><T><A><A><D><S><E><S><T><T><N><V><N><S><L><A><T><S><D><I><I><T><A><S><S><P><N><D><G><L><I><T><M><V><P><S><E><T><Q><S><N><N><E><M><S><P><T><T><E><D><N><Q><S><S><G><P><P><T><G><T><A><L><L><E><T><S><T><L><N><S><T><G><P><S><N><P><C><Q><D><D><P><C><A><D><N><S><L><C><V><K><L><H><N><T><S><F><C><L><C><L><E><G><Y><Y><Y><N><S><S><T><C><K><K><G><K><V><F><P><G><K><I><S><V><T><V><S><E><T><F><D><P><E><E><K><H><S><M><A><Y><Q><D><L><H><S><E><I><T><S><L><F><K><D><V><F><G><T><S><V><Y><G><Q><T><V><I><L><T><V><S><T><S><L><S><P><R><S><E><M><R><A><D><D><K><F><V><N><V><T><I><V><T><I><L><A><E><T><T><S><D><N><E><K><T><V><T><E><K><I><N><K><A><I><R><S><S><S><S><N><F><L><N><Y><D><L><T><L><R><C><D><Y><Y><G><C><N><Q><T><A><D><D><C><L><N><G><L><A><C><D><C><K><S><D><L><Q><R><P><N><P><Q><S><P><F><C><V><A><S><S><L><K><C><P><D><A><C><N><A><Q><H><K><Q><C><L><I><K><K><S><G><G><A><P><E><C><A><C><V><P><G><Y><Q><E><D><A><N><G><N><C><Q><K><C><A><F><G><Y><S><G><L><D><C><K><D><K><F><Q><L><I><L><T><I><V><G><T><I><A><G><I><V><I><L><S><M><I><I><A><L><I><V><T><A><R><S><N><N><K><T><K><H><I><E><E><E><N><L><I><D><E><D><F><Q><N><L><K><L><R><S><T><G><F><T><N><L><G><A><E><G><S><V><F><P><K><V><R><I><T><A><S><R><D><S><Q><M><Q><N><P><Y><S><R><H><S><S><M><P><R><P><D><Y>
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Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.<BOP>
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Q9H3R2
|
Q9H871
|
RMD5A_HUMAN
|
Protein RMD5 homolog A
|
Homo
|
<M><D><Q><C><V><T><V><E><R><E><L><E><K><V><L><H><K><F><S><G><Y><G><Q><L><C><E><R><G><L><E><E><L><I><D><Y><T><G><G><L><K><H><E><I><L><Q><S><H><G><Q><D><A><E><L><S><G><T><L><S><L><V><L><T><Q><C><C><K><R><I><K><D><T><V><Q><K><L><A><S><D><H><K><D><I><H><S><S><V><S><R><V><G><K><A><I><D><K><N><F><D><S><D><I><S><S><V><G><I><D><G><C><W><Q><A><D><S><Q><R><L><L><N><E><V><M><V><E><H><F><F><R><Q><G><M><L><D><V><A><E><E><L><C><Q><E><S><G><L><S><V><D><P><S><Q><K><E><P><F><V><E><L><N><R><I><L><E><A><L><K><V><R><V><L><R><P><A><L><E><W><A><V><S><N><R><E><M><L><I><A><Q><N><S><S><L><E><F><K><L><H><R><L><Y><F><I><S><L><L><M><G><G><T><T><N><Q><R><E><A><L><Q><Y><A><K><N><F><Q><P><F><A><L><N><H><Q><K><D><I><Q><V><L><M><G><S><L><V><Y><L><R><Q><G><I><E><N><S><P><Y><V><H><L><L><D><A><N><Q><W><A><D><I><C><D><I><F><T><R><D><A><C><A><L><L><G><L><S><V><E><S><P><L><S><V><S><F><S><A><G><C><V><A><L><P><A><L><I><N><I><K><A><V><I><E><Q><R><Q><C><T><G><V><W><N><Q><K><D><E><L><P><I><E><V><D><L><G><K><K><C><W><Y><H><S><I><F><A><C><P><I><L><R><Q><Q><T><T><D><N><N><P><P><M><K><L><V><C><G><H><I><I><S><R><D><A><L><N><K><M><F><N><G><S><K><L><K><C><P><Y><C><P><M><E><Q><S><P><G><D><A><K><Q><I><F><F>
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Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . Catalytic activity of the complex is required for normal cell proliferation . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 .<BOP>
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Q9H871
|
P01236
|
PRL_HUMAN
|
Prolactin
|
Homo
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<M><N><I><K><G><S><P><W><K><G><S><L><L><L><L><L><V><S><N><L><L><L><C><Q><S><V><A><P><L><P><I><C><P><G><G><A><A><R><C><Q><V><T><L><R><D><L><F><D><R><A><V><V><L><S><H><Y><I><H><N><L><S><S><E><M><F><S><E><F><D><K><R><Y><T><H><G><R><G><F><I><T><K><A><I><N><S><C><H><T><S><S><L><A><T><P><E><D><K><E><Q><A><Q><Q><M><N><Q><K><D><F><L><S><L><I><V><S><I><L><R><S><W><N><E><P><L><Y><H><L><V><T><E><V><R><G><M><Q><E><A><P><E><A><I><L><S><K><A><V><E><I><E><E><Q><T><K><R><L><L><E><G><M><E><L><I><V><S><Q><V><H><P><E><T><K><E><N><E><I><Y><P><V><W><S><G><L><P><S><L><Q><M><A><D><E><E><S><R><L><S><A><Y><Y><N><L><L><H><C><L><R><R><D><S><H><K><I><D><N><Y><L><K><L><L><K><C><R><I><I><H><N><N><N><C>
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Prolactin acts primarily on the mammary gland by promoting lactation.<BOP>
|
P01236
|
Q9Y2Z4
|
SYYM_HUMAN
|
Tyrosyl-tRNA synthetase
|
Homo
|
<M><A><A><P><I><L><R><S><F><S><W><G><R><W><S><G><T><L><N><L><S><V><L><L><P><L><G><L><R><K><A><H><S><G><A><Q><G><L><L><A><A><Q><K><A><R><G><L><F><K><D><F><F><P><E><T><G><T><K><I><E><L><P><E><L><F><D><R><G><T><A><S><F><P><Q><T><I><Y><C><G><F><D><P><T><A><D><S><L><H><V><G><H><L><L><A><L><L><G><L><F><H><L><Q><R><A><G><H><N><V><I><A><L><V><G><G><A><T><A><R><L><G><D><P><S><G><R><T><K><E><R><E><A><L><E><T><E><R><V><R><A><N><A><R><A><L><R><L><G><L><E><A><L><A><A><N><H><Q><Q><L><F><T><D><G><R><S><W><G><S><F><T><V><L><D><N><S><A><W><Y><Q><K><Q><H><L><V><D><F><L><A><A><V><G><G><H><F><R><M><G><T><L><L><S><R><Q><S><V><Q><L><R><L><K><S><P><E><G><M><S><L><A><E><F><F><Y><Q><V><L><Q><A><Y><D><F><Y><Y><L><F><Q><R><Y><G><C><R><V><Q><L><G><G><S><D><Q><L><G><N><I><M><S><G><Y><E><F><I><N><K><L><T><G><E><D><V><F><G><I><T><V><P><L><I><T><S><T><T><G><A><K><L><G><K><S><A><G><N><A><V><W><L><N><R><D><K><T><S><P><F><E><L><Y><Q><F><F><V><R><Q><P><D><D><S><V><E><R><Y><L><K><L><F><T><F><L><P><L><P><E><I><D><H><I><M><Q><L><H><V><K><E><P><E><R><R><G><P><Q><K><R><L><A><A><E><V><T><K><L><V><H><G><R><E><G><L><D><S><A><K><R><C><T><Q><A><L><Y><H><S><S><I><D><A><L><E><V><M><S><D><Q><E><L><K><E><L><F><K><E><A><P><F><S><E><F><F><L><D><P><G><T><S><V><L><D><T><C><R><K><A><N><A><I><P><D><G><P><R><G><Y><R><M><I><T><E><G><G><V><S><I><N><H><Q><Q><V><T><N><P><E><S><V><L><I><V><G><Q><H><I><L><K><N><G><L><S><L><L><K><I><G><K><R><N><F><Y><I><I><K><W><L><Q><L>
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Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<BOP>
|
Q9Y2Z4
|
Q8IVW6
|
ARI3B_HUMAN
|
Bright-like protein
|
Homo
|
<M><E><P><L><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><K><Q><P><H><L><A><P><L><Q><M><D><A><R><E><K><Q><G><Q><Q><M><R><E><A><Q><F><L><Y><A><Q><K><L><V><T><Q><P><T><L><L><S><A><T><A><G><R><P><S><G><S><T><P><L><G><P><L><A><R><V><P><P><T><A><A><V><A><Q><V><F><E><R><G><N><M><N><S><E><P><E><E><E><D><G><G><L><E><D><E><D><G><D><D><E><V><A><E><V><A><E><K><E><T><Q><A><A><S><K><Y><F><H><V><Q><K><V><A><R><Q><D><P><R><V><A><P><M><S><N><L><L><P><A><P><G><L><P><P><H><G><Q><Q><A><K><E><D><H><T><K><D><A><S><K><A><S><P><S><V><S><T><A><G><Q><P><N><W><N><L><D><E><Q><L><K><Q><N><G><G><L><A><W><S><D><D><A><D><G><G><R><G><R><E><I><S><R><D><F><A><K><L><Y><E><L><D><G><D><P><E><R><K><E><F><L><D><D><L><F><V><F><M><Q><K><R><G><T><P><I><N><R><I><P><I><M><A><K><Q><I><L><D><L><Y><M><L><Y><K><L><V><T><E><K><G><G><L><V><E><I><I><N><K><K><I><W><R><E><I><T><K><G><L><N><L><P><T><S><I><T><S><A><A><F><T><L><R><T><Q><Y><M><K><Y><L><Y><A><Y><E><C><E><K><K><A><L><S><S><P><A><E><L><Q><A><A><I><D><G><N><R><R><E><G><R><R><P><S><Y><S><S><S><L><F><G><Y><S><P><A><A><A><T><A><A><A><A><A><G><A><P><A><L><L><S><P><P><K><I><R><F><P><I><L><G><L><G><S><S><S><G><T><N><T><S><S><P><R><I><S><P><A><T><T><L><R><K><G><D><G><A><P><V><T><T><V><P><V><P><N><R><L><A><V><P><V><T><L><A><S><Q><Q><A><G><T><R><T><A><A><L><E><Q><L><R><E><R><L><E><S><G><E><P><A><E><K><K><A><S><R><L><S><E><E><E><Q><R><L><V><Q><Q><A><F><Q><R><N><F><F><S><M><A><R><Q><L><P><M><K><I><R><I><N><G><R><A><E><D><R><A><E><A><S><A><A><A><L><N><L><T><T><S><S><I><G><S><I><N><M><S><V><D><I><D><G><T><T><Y><A><G><V><L><F><A><Q><K><P><V><V><H><L><I><T><G><S><A><P><Q><S><L><G><S><S><A><S><S><S><S><S><S><H><C><S><P><S><P><T><S><S><R><G><T><P><S><A><E><P><S><T><S><W><S><L>
|
Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.<BOP>
|
Q8IVW6
|
Q9HB89
|
NMUR1_HUMAN
|
G-protein coupled receptor FM-3
|
Homo
|
<M><T><P><L><C><L><N><C><S><V><L><P><G><D><L><Y><P><G><G><A><R><N><P><M><A><C><N><G><S><A><A><R><G><H><F><D><P><E><D><L><N><L><T><D><E><A><L><R><L><K><Y><L><G><P><Q><Q><T><E><L><F><M><P><I><C><A><T><Y><L><L><I><F><V><V><G><A><V><G><N><G><L><T><C><L><V><I><L><R><H><K><A><M><R><T><P><T><N><Y><Y><L><F><S><L><A><V><S><D><L><L><V><L><L><V><G><L><P><L><E><L><Y><E><M><W><H><N><Y><P><F><L><L><G><V><G><G><C><Y><F><R><T><L><L><F><E><M><V><C><L><A><S><V><L><N><V><T><A><L><S><V><E><R><Y><V><A><V><V><H><P><L><Q><A><R><S><M><V><T><R><A><H><V><R><R><V><L><G><A><V><W><G><L><A><M><L><C><S><L><P><N><T><S><L><H><G><I><R><Q><L><H><V><P><C><R><G><P><V><P><D><S><A><V><C><M><L><V><R><P><R><A><L><Y><N><M><V><V><Q><T><T><A><L><L><F><F><C><L><P><M><A><I><M><S><V><L><Y><L><L><I><G><L><R><L><R><R><E><R><L><L><L><M><Q><E><A><K><G><R><G><S><A><A><A><R><S><R><Y><T><C><R><L><Q><Q><H><D><R><G><R><R><Q><V><T><K><M><L><F><V><L><V><V><V><F><G><I><C><W><A><P><F><H><A><D><R><V><M><W><S><V><V><S><Q><W><T><D><G><L><H><L><A><F><Q><H><V><H><V><I><S><G><I><F><F><Y><L><G><S><A><A><N><P><V><L><Y><S><L><M><S><S><R><F><R><E><T><F><Q><E><A><L><C><L><G><A><C><C><H><R><L><R><P><R><H><S><S><H><S><L><S><R><M><T><T><G><S><T><L><C><D><V><G><S><L><G><S><W><V><H><P><L><A><G><N><D><G><P><E><A><Q><Q><E><T><D><P><S>
|
Receptor for the neuromedin-U and neuromedin-S neuropeptides.<BOP>
|
Q9HB89
|
P63162
|
RSMN_HUMAN
|
Tissue-specific-splicing protein
|
Homo
|
<M><T><V><G><K><S><S><K><M><L><Q><H><I><D><Y><R><M><R><C><I><L><Q><D><G><R><I><F><I><G><T><F><K><A><F><D><K><H><M><N><L><I><L><C><D><C><D><E><F><R><K><I><K><P><K><N><A><K><Q><P><E><R><E><E><K><R><V><L><G><L><V><L><L><R><G><E><N><L><V><S><M><T><V><E><G><P><P><P><K><D><T><G><I><A><R><V><P><L><A><G><A><A><G><G><P><G><V><G><R><A><A><G><R><G><V><P><A><G><V><P><I><P><Q><A><P><A><G><L><A><G><P><V><R><G><V><G><G><P><S><Q><Q><V><M><T><P><Q><G><R><G><T><V><A><A><A><A><V><A><A><T><A><S><I><A><G><A><P><T><Q><Y><P><P><G><R><G><T><P><P><P><P><V><G><R><A><T><P><P><P><G><I><M><A><P><P><P><G><M><R><P><P><M><G><P><P><I><G><L><P><P><A><R><G><T><P><I><G><M><P><P><P><G><M><R><P><P><P><P><G><I><R><G><P><P><P><P><G><M><R><P><P><R><P>
|
May be involved in tissue-specific alternative RNA processing events.<BOP>
|
P63162
|
Q9NR83
|
S2A4R_HUMAN
|
Huntington disease gene regulatory region-binding protein 1
|
Homo
|
<M><E><R><P><P><P><R><A><A><G><R><D><P><S><A><L><R><A><E><A><P><W><L><R><A><E><G><P><G><P><R><A><A><P><V><T><V><P><T><P><P><Q><G><S><S><V><G><G><G><F><A><G><L><E><F><A><R><P><Q><E><S><E><P><R><A><S><D><L><G><A><P><R><T><W><T><G><A><A><A><G><P><R><T><P><S><A><H><I><P><V><P><A><Q><R><A><T><P><G><K><A><R><L><D><E><V><M><A><A><A><A><L><T><S><L><S><T><S><P><L><L><L><G><A><P><V><A><A><F><S><P><E><P><G><L><E><P><W><K><E><A><L><V><R><P><P><G><S><Y><S><S><S><S><N><S><G><D><W><G><W><D><L><A><S><D><Q><S><S><P><S><T><P><S><P><P><L><P><P><E><A><A><H><F><L><F><G><E><P><T><L><R><K><R><K><S><P><A><Q><V><M><F><Q><C><L><W><K><S><C><G><K><V><L><S><T><A><S><A><M><Q><R><H><I><R><L><V><H><L><G><R><Q><A><E><P><E><Q><S><D><G><E><E><D><F><Y><Y><T><E><L><D><V><G><V><D><T><L><T><D><G><L><S><S><L><T><P><V><S><P><T><A><S><M><P><P><A><F><P><R><L><E><L><P><E><L><L><E><P><P><A><L><P><S><P><L><R><P><P><A><P><P><L><P><P><P><P><V><L><S><T><V><A><N><P><Q><S><C><H><S><D><R><V><Y><Q><G><C><L><T><P><A><R><L><E><P><Q><P><T><E><V><G><A><C><P><P><A><L><S><S><R><I><G><V><T><L><R><K><P><R><G><D><A><K><K><C><R><K><V><Y><G><M><E><R><R><D><L><W><C><T><A><C><R><W><K><K><A><C><Q><R><F><L><D>
|
Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.<BOP>
|
Q9NR83
|
P40425
|
PBX2_HUMAN
|
Protein G17
|
Homo
|
<M><D><E><R><L><L><G><P><P><P><P><G><G><G><R><G><G><L><G><L><V><S><G><E><P><G><G><P><G><E><P><P><G><G><G><D><P><G><G><G><S><G><G><V><P><G><G><R><G><K><Q><D><I><G><D><I><L><Q><Q><I><M><T><I><T><D><Q><S><L><D><E><A><Q><A><K><K><H><A><L><N><C><H><R><M><K><P><A><L><F><S><V><L><C><E><I><K><E><K><T><G><L><S><I><R><S><S><Q><E><E><E><P><V><D><P><Q><L><M><R><L><D><N><M><L><L><A><E><G><V><A><G><P><E><K><G><G><G><S><A><A><A><A><A><A><A><A><A><S><G><G><G><V><S><P><D><N><S><I><E><H><S><D><Y><R><S><K><L><A><Q><I><R><H><I><Y><H><S><E><L><E><K><Y><E><Q><A><C><N><E><F><T><T><H><V><M><N><L><L><R><E><Q><S><R><T><R><P><V><A><P><K><E><M><E><R><M><V><S><I><I><H><R><K><F><S><A><I><Q><M><Q><L><K><Q><S><T><C><E><A><V><M><I><L><R><S><R><F><L><D><A><R><R><K><R><R><N><F><S><K><Q><A><T><E><V><L><N><E><Y><F><Y><S><H><L><S><N><P><Y><P><S><E><E><A><K><E><E><L><A><K><K><C><G><I><T><V><S><Q><V><S><N><W><F><G><N><K><R><I><R><Y><K><K><N><I><G><K><F><Q><E><E><A><N><I><Y><A><V><K><T><A><V><S><V><T><Q><G><G><H><S><R><T><S><S><P><T><P><P><S><S><A><G><S><G><G><S><F><N><L><S><G><S><G><D><M><F><L><G><M><P><G><L><N><G><D><S><Y><S><A><S><Q><V><E><S><L><R><H><S><M><G><P><G><G><Y><G><D><N><L><G><G><G><Q><M><Y><S><P><R><E><M><R><A><N><G><S><W><Q><E><A><V><T><P><S><S><V><T><S><P><T><E><G><P><G><S><V><H><S><D><T><S><N>
|
Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.<BOP>
|
P40425
|
P46783
|
RS10_HUMAN
|
Small ribosomal subunit protein eS10
|
Homo
|
<M><L><M><P><K><K><N><R><I><A><I><Y><E><L><L><F><K><E><G><V><M><V><A><K><K><D><V><H><M><P><K><H><P><E><L><A><D><K><N><V><P><N><L><H><V><M><K><A><M><Q><S><L><K><S><R><G><Y><V><K><E><Q><F><A><W><R><H><F><Y><W><Y><L><T><N><E><G><I><Q><Y><L><R><D><Y><L><H><L><P><P><E><I><V><P><A><T><L><R><R><S><R><P><E><T><G><R><P><R><P><K><G><L><E><G><E><R><P><A><R><L><T><R><G><E><A><D><R><D><T><Y><R><R><S><A><V><P><P><G><A><D><K><K><A><E><A><G><A><G><S><A><T><E><F><Q><F><R><G><G><F><G><R><G><R><G><Q><P><P><Q>
|
Component of the 40S ribosomal subunit.<BOP>
|
P46783
|
Q6ZTI6
|
RFLA_HUMAN
|
Regulator of filamin protein A
|
Homo
|
<M><V><G><H><L><H><L><Q><G><M><E><D><S><L><K><E><Q><G><R><E><G><L><L><D><S><P><D><S><G><L><P><P><S><P><S><P><S><P><P><F><Y><S><L><A><P><G><I><L><D><A><R><A><G><G><A><G><A><S><S><E><P><P><G><P><S><E><A><R><A><P><P><S><Q><L><P><N><P><P><A><S><E><M><R><P><R><M><L><P><V><F><F><G><E><S><I><K><V><N><P><E><P><T><H><E><I><R><C><N><S><E><V><K><Y><A><S><E><K><H><F><Q><D><K><V><F><Y><A><P><V><P><T><V><T><A><Y><S><E><T><I><V><A><A><P><N><C><T><W><R><N><Y><R><S><Q><L><T><L><E><P><R><P><R><A><L><R><F><R><S><T><T><I><I><F><P><K><H><A><R><S><T><F><R><T><T><L><H><C><S><L><G><R><P><S><R><W><F><T><A><S><V><Q><L><Q><L><C><Q><D><P><A><P><S><L><L><G><P><A><T><L>
|
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.<BOP>
|
Q6ZTI6
|
Q9H3D4
|
P63_HUMAN
|
p51
|
Homo
|
<M><N><F><E><T><S><R><C><A><T><L><Q><Y><C><P><D><P><Y><I><Q><R><F><V><E><T><P><A><H><F><S><W><K><E><S><Y><Y><R><S><T><M><S><Q><S><T><Q><T><N><E><F><L><S><P><E><V><F><Q><H><I><W><D><F><L><E><Q><P><I><C><S><V><Q><P><I><D><L><N><F><V><D><E><P><S><E><D><G><A><T><N><K><I><E><I><S><M><D><C><I><R><M><Q><D><S><D><L><S><D><P><M><W><P><Q><Y><T><N><L><G><L><L><N><S><M><D><Q><Q><I><Q><N><G><S><S><S><T><S><P><Y><N><T><D><H><A><Q><N><S><V><T><A><P><S><P><Y><A><Q><P><S><S><T><F><D><A><L><S><P><S><P><A><I><P><S><N><T><D><Y><P><G><P><H><S><F><D><V><S><F><Q><Q><S><S><T><A><K><S><A><T><W><T><Y><S><T><E><L><K><K><L><Y><C><Q><I><A><K><T><C><P><I><Q><I><K><V><M><T><P><P><P><Q><G><A><V><I><R><A><M><P><V><Y><K><K><A><E><H><V><T><E><V><V><K><R><C><P><N><H><E><L><S><R><E><F><N><E><G><Q><I><A><P><P><S><H><L><I><R><V><E><G><N><S><H><A><Q><Y><V><E><D><P><I><T><G><R><Q><S><V><L><V><P><Y><E><P><P><Q><V><G><T><E><F><T><T><V><L><Y><N><F><M><C><N><S><S><C><V><G><G><M><N><R><R><P><I><L><I><I><V><T><L><E><T><R><D><G><Q><V><L><G><R><R><C><F><E><A><R><I><C><A><C><P><G><R><D><R><K><A><D><E><D><S><I><R><K><Q><Q><V><S><D><S><T><K><N><G><D><G><T><K><R><P><F><R><Q><N><T><H><G><I><Q><M><T><S><I><K><K><R><R><S><P><D><D><E><L><L><Y><L><P><V><R><G><R><E><T><Y><E><M><L><L><K><I><K><E><S><L><E><L><M><Q><Y><L><P><Q><H><T><I><E><T><Y><R><Q><Q><Q><Q><Q><Q><H><Q><H><L><L><Q><K><Q><T><S><I><Q><S><P><S><S><Y><G><N><S><S><P><P><L><N><K><M><N><S><M><N><K><L><P><S><V><S><Q><L><I><N><P><Q><Q><R><N><A><L><T><P><T><T><I><P><D><G><M><G><A><N><I><P><M><M><G><T><H><M><P><M><A><G><D><M><N><G><L><S><P><T><Q><A><L><P><P><P><L><S><M><P><S><T><S><H><C><T><P><P><P><P><Y><P><T><D><C><S><I><V><S><F><L><A><R><L><G><C><S><S><C><L><D><Y><F><T><T><Q><G><L><T><T><I><Y><Q><I><E><H><Y><S><M><D><D><L><A><S><L><K><I><P><E><Q><F><R><H><A><I><W><K><G><I><L><D><H><R><Q><L><H><E><F><S><S><P><S><H><L><L><R><T><P><S><S><A><S><T><V><S><V><G><S><S><E><T><R><G><E><R><V><I><D><A><V><R><F><T><L><R><Q><T><I><S><F><P><P><R><D><E><W><N><D><F><N><F><D><M><D><A><R><R><N><K><Q><Q><R><I><K><E><E><G><E>
|
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.<BOP>
|
Q9H3D4
|
Q9HCE7
|
SMUF1_HUMAN
|
SMAD-specific E3 ubiquitin-protein ligase 1
|
Homo
|
<M><S><N><P><G><T><R><R><N><G><S><S><I><K><I><R><L><T><V><L><C><A><K><N><L><A><K><K><D><F><F><R><L><P><D><P><F><A><K><I><V><V><D><G><S><G><Q><C><H><S><T><D><T><V><K><N><T><L><D><P><K><W><N><Q><H><Y><D><L><Y><V><G><K><T><D><S><I><T><I><S><V><W><N><H><K><K><I><H><K><K><Q><G><A><G><F><L><G><C><V><R><L><L><S><N><A><I><S><R><L><K><D><T><G><Y><Q><R><L><D><L><C><K><L><N><P><S><D><T><D><A><V><R><G><Q><I><V><V><S><L><Q><T><R><D><R><I><G><T><G><G><S><V><V><D><C><R><G><L><L><E><N><E><G><T><V><Y><E><D><S><G><P><G><R><P><L><S><C><F><M><E><E><P><A><P><Y><T><D><S><T><G><A><A><A><G><G><G><N><C><R><F><V><E><S><P><S><Q><D><Q><R><L><Q><A><Q><R><L><R><N><P><D><V><R><G><S><L><Q><T><P><Q><N><R><P><H><G><H><Q><S><P><E><L><P><E><G><Y><E><Q><R><T><T><V><Q><G><Q><V><Y><F><L><H><T><Q><T><G><V><S><T><W><H><D><P><R><I><P><S><P><S><G><T><I><P><G><G><D><A><A><F><L><Y><E><F><L><L><Q><G><H><T><S><E><P><R><D><L><N><S><V><N><C><D><E><L><G><P><L><P><P><G><W><E><V><R><S><T><V><S><G><R><I><Y><F><V><D><H><N><N><R><T><T><Q><F><T><D><P><R><L><H><H><I><M><N><H><Q><C><Q><L><K><E><P><S><Q><P><L><P><L><P><S><E><G><S><L><E><D><E><E><L><P><A><Q><R><Y><E><R><D><L><V><Q><K><L><K><V><L><R><H><E><L><S><L><Q><Q><P><Q><A><G><H><C><R><I><E><V><S><R><E><E><I><F><E><E><S><Y><R><Q><I><M><K><M><R><P><K><D><L><K><K><R><L><M><V><K><F><R><G><E><E><G><L><D><Y><G><G><V><A><R><E><W><L><Y><L><L><C><H><E><M><L><N><P><Y><Y><G><L><F><Q><Y><S><T><D><N><I><Y><M><L><Q><I><N><P><D><S><S><I><N><P><D><H><L><S><Y><F><H><F><V><G><R><I><M><G><L><A><V><F><H><G><H><Y><I><N><G><G><F><T><V><P><F><Y><K><Q><L><L><G><K><P><I><Q><L><S><D><L><E><S><V><D><P><E><L><H><K><S><L><V><W><I><L><E><N><D><I><T><P><V><L><D><H><T><F><C><V><E><H><N><A><F><G><R><I><L><Q><H><E><L><K><P><N><G><R><N><V><P><V><T><E><E><N><K><K><E><Y><V><R><L><Y><V><N><W><R><F><M><R><G><I><E><A><Q><F><L><A><L><Q><K><G><F><N><E><L><I><P><Q><H><L><L><K><P><F><D><Q><K><E><L><E><L><I><I><G><G><L><D><K><I><D><L><N><D><W><K><S><N><T><R><L><K><H><C><V><A><D><S><N><I><V><R><W><F><W><Q><A><V><E><T><F><D><E><E><R><R><A><R><L><L><Q><F><V><T><G><S><T><R><V><P><L><Q><G><F><K><A><L><Q><G><S><T><G><A><A><G><P><R><L><F><T><I><H><L><I><D><A><N><T><D><N><L><P><K><A><H><T><C><F><N><R><I><D><I><P><P><Y><E><S><Y><E><K><L><Y><E><K><L><L><T><A><V><E><E><T><C><G><F><A><V><E>
|
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .<BOP>
|
Q9HCE7
|
Q15646
|
OASL_HUMAN
|
p59 OASL
|
Homo
|
<M><A><L><M><Q><E><L><Y><S><T><P><A><S><R><L><D><S><F><V><A><Q><W><L><Q><P><H><R><E><W><K><E><E><V><L><D><A><V><R><T><V><E><E><F><L><R><Q><E><H><F><Q><G><K><R><G><L><D><Q><D><V><R><V><L><K><V><V><K><V><G><S><F><G><N><G><T><V><L><R><S><T><R><E><V><E><L><V><A><F><L><S><C><F><H><S><F><Q><E><A><A><K><H><H><K><D><V><L><R><L><I><W><K><T><M><W><Q><S><Q><D><L><L><D><L><G><L><E><D><L><R><M><E><Q><R><V><P><D><A><L><V><F><T><I><Q><T><R><G><T><A><E><P><I><T><V><T><I><V><P><A><Y><R><A><L><G><P><S><L><P><N><S><Q><P><P><P><E><V><Y><V><S><L><I><K><A><C><G><G><P><G><N><F><C><P><S><F><S><E><L><Q><R><N><F><V><K><H><R><P><T><K><L><K><S><L><L><R><L><V><K><H><W><Y><Q><Q><Y><V><K><A><R><S><P><R><A><N><L><P><P><L><Y><A><L><E><L><L><T><I><Y><A><W><E><M><G><T><E><E><D><E><N><F><M><L><D><E><G><F><T><T><V><M><D><L><L><L><E><Y><E><V><I><C><I><Y><W><T><K><Y><Y><T><L><H><N><A><I><I><E><D><C><V><R><K><Q><L><K><K><E><R><P><I><I><L><D><P><A><D><P><T><L><N><V><A><E><G><Y><R><W><D><I><V><A><Q><R><A><S><Q><C><L><K><Q><D><C><C><Y><D><N><R><E><N><P><I><S><S><W><N><V><K><R><A><R><D><I><H><L><T><V><E><Q><R><G><Y><P><D><F><N><L><I><V><N><P><Y><E><P><I><R><K><V><K><E><K><I><R><R><T><R><G><Y><S><G><L><Q><R><L><S><F><Q><V><P><G><S><E><R><Q><L><L><S><S><R><C><S><L><A><K><Y><G><I><F><S><H><T><H><I><Y><L><L><E><T><I><P><S><E><I><Q><V><F><V><K><N><P><D><G><G><S><Y><A><Y><A><I><N><P><N><S><F><I><L><G><L><K><Q><Q><I><E><D><Q><Q><G><L><P><K><K><Q><Q><Q><L><E><F><Q><G><Q><V><L><Q><D><W><L><G><L><G><I><Y><G><I><Q><D><S><D><T><L><I><L><S><K><K><K><G><E><A><L><F><P><A><S>
|
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.<BOP>
|
Q15646
|
Q96LJ7
|
DHRS1_HUMAN
|
Short chain dehydrogenase/reductase family 19C member 1
|
Homo
|
<M><A><A><P><M><N><G><Q><V><C><V><V><T><G><A><S><R><G><I><G><R><G><I><A><L><Q><L><C><K><A><G><A><T><V><Y><I><T><G><R><H><L><D><T><L><R><V><V><A><Q><E><A><Q><S><L><G><G><Q><C><V><P><V><V><C><D><S><S><Q><E><S><E><V><R><S><L><F><E><Q><V><D><R><E><Q><Q><G><R><L><D><V><L><V><N><N><A><Y><A><G><V><Q><T><I><L><N><T><R><N><K><A><F><W><E><T><P><A><S><M><W><D><D><I><N><N><V><G><L><R><G><H><Y><F><C><S><V><Y><G><A><R><L><M><V><P><A><G><Q><G><L><I><V><V><I><S><S><P><G><S><L><Q><Y><M><F><N><V><P><Y><G><V><G><K><A><A><C><D><K><L><A><A><D><C><A><H><E><L><R><R><H><G><V><S><C><V><S><L><W><P><G><I><V><Q><T><E><L><L><K><E><H><M><A><K><E><E><V><L><Q><D><P><V><L><K><Q><F><K><S><A><F><S><S><A><E><T><T><E><L><S><G><K><C><V><V><A><L><A><T><D><P><N><I><L><S><L><S><G><K><V><L><P><S><C><D><L><A><R><R><Y><G><L><R><D><V><D><G><R><P><V><Q><D><Y><L><S><L><S><S><V><L><S><H><V><S><G><L><G><W><L><A><S><Y><L><P><S><F><L><R><V><P><K><W><I><I><A><L><Y><T><S><K><F>
|
NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro . May have a role in steroid and/or xenobiotic metabolism .<BOP>
|
Q96LJ7
|
Q5T4W7
|
ARTN_HUMAN
|
Neublastin
|
Homo
|
<M><E><L><G><L><G><G><L><S><T><L><S><H><C><P><W><P><R><Q><Q><P><A><L><W><P><T><L><A><A><L><A><L><L><S><S><V><A><E><A><S><L><G><S><A><P><R><S><P><A><P><R><E><G><P><P><P><V><L><A><S><P><A><G><H><L><P><G><G><R><T><A><R><W><C><S><G><R><A><R><R><P><P><P><Q><P><S><R><P><A><P><P><P><P><A><P><P><S><A><L><P><R><G><G><R><A><A><R><A><G><G><P><G><S><R><A><R><A><A><G><A><R><G><C><R><L><R><S><Q><L><V><P><V><R><A><L><G><L><G><H><R><S><D><E><L><V><R><F><R><F><C><S><G><S><C><R><R><A><R><S><P><H><D><L><S><L><A><S><L><L><G><A><G><A><L><R><P><P><P><G><S><R><P><V><S><Q><P><C><C><R><P><T><R><Y><E><A><V><S><F><M><D><V><N><S><T><W><R><T><V><D><R><L><S><A><T><A><C><G><C><L><G>
|
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.<BOP>
|
Q5T4W7
|
Q99766
|
ATP5S_HUMAN
|
Mitochondrial ATP synthase regulatory component factor B
|
Homo
|
<M><C><C><A><V><S><E><Q><R><L><T><C><A><D><Q><M><M><P><F><G><K><I><S><Q><Q><L><C><G><V><K><K><L><P><W><S><C><D><S><R><Y><F><W><G><W><L><N><A><V><F><N><K><V><D><Y><D><R><I><R><D><V><G><P><D><R><A><A><S><E><W><L><L><R><C><G><A><M><V><R><Y><H><G><Q><E><R><W><Q><K><D><Y><N><H><L><P><T><G><P><L><D><K><Y><K><I><Q><A><I><D><A><T><D><S><C><I><M><S><I><G><F><D><H><M><E><G><L><E><H><V><E><K><I><R><L><C><K><C><H><Y><I><E><D><D><C><L><L><R><L><S><Q><L><E><N><L><Q><K><T><I><L><E><M><E><I><I><S><C><G><N><I><T><D><K><G><I><I><A><L><R><H><L><R><N><L><K><Y><L><L><L><S><D><L><P><G><V><R><E><K><E><N><L><V><Q><A><F><K><T><A><L><P><S><L><E><L><K><L><Q><L><K>
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Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.<BOP>
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Q99766
|
Q6A163
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K1C39_HUMAN
|
Type I hair keratin Ka35
|
Homo
|
<M><D><T><K><G><C><T><T><T><N><S><P><S><T><P><C><Q><N><C><S><R><I><T><N><V><S><T><I><S><S><N><N><G><C><H><P><G><G><L><T><V><N><N><C><Q><P><A><G><H><V><L><R><I><P><W><D><Q><G><C><Q><P><T><P><R><F><C><R><K><P><I><Y><L><M><N><N><F><N><A><R><F><S><L><D><D><C><S><W><Y><G><E><G><I><N><S><N><E><K><E><T><M><Q><I><L><N><E><R><L><A><N><Y><L><Q><K><V><R><M><L><E><R><E><N><A><E><L><E><S><K><I><Q><E><E><S><N><K><E><L><P><V><L><C><P><D><Y><L><S><Y><Y><T><T><I><E><E><L><Q><Q><K><I><L><C><T><K><A><E><N><S><R><L><V><S><Q><I><D><N><T><K><L><T><A><D><D><L><R><A><K><Y><E><A><E><V><S><L><R><Q><L><V><E><S><D><A><N><G><L><K><Q><I><L><N><V><L><T><L><G><K><A><D><L><E><A><Q><V><Q><S><L><K><E><E><L><L><C><L><K><N><N><H><K><E><E><I><N><S><L><Q><C><Q><L><G><E><R><L><D><I><E><V><T><A><A><P><S><A><D><L><N><Q><V><L><Q><E><M><R><C><Q><Y><E><P><I><M><E><T><N><R><K><D><V><E><Q><W><F><N><T><Q><I><E><E><L><N><Q><Q><V><V><T><S><S><Q><Q><Q><Q><C><C><Q><K><E><I><I><E><L><R><R><S><V><N><T><L><E><V><E><L><Q><A><Q><H><R><M><R><D><S><Q><E><C><I><L><T><E><T><E><A><R><Y><T><A><L><L><T><Q><I><Q><S><L><I><D><N><L><E><A><Q><L><A><E><I><R><C><A><L><E><R><Q><N><Q><E><Y><E><I><L><L><D><V><K><S><R><L><E><C><E><I><T><T><Y><R><S><L><L><E><S><S><D><G><K><R><P><C><Y><P><R><A><T><K><C><E><P><S><P><W><T><S><C><K><S><G><A><I><E><S><T><A><P><A><C><T><S><S><S><P><C><S><L><K><E><H><C><S><A><C><G><P><L><S><R><I><L><V><K><I><C><T><I><T><K><E><I><K><D><G><K><V><I><S><S><Y><E><H><V><Q><P><C><F><I><I><R><P><A><K><V>
|
May play a role in late hair differentiation.<BOP>
|
Q6A163
|
Q86UT5
|
NHRF4_HUMAN
|
Sodium-hydrogen exchanger regulatory factor 4
|
Homo
|
<M><V><T><P><S><P><P><G><N><H><S><L><S><L><E><A><P><R><L><H><T><A><S><D><L><L><G><N><H><S><L><G><L><P><L><I><T><A><L><V><G><S><R><D><R><R><G><R><V><F><S><P><V><P><V><P><L><P><T><N><P><T><T><Q><H><P><T><R><Q><K><L><P><S><T><L><S><G><H><R><V><C><Q><A><H><G><E><P><V><L><G><L><C><P><L><L><P><L><F><C><C><P><P><H><P><P><D><P><W><S><L><E><R><P><R><F><C><L><L><S><K><E><E><G><K><S><F><G><F><H><L><Q><Q><E><L><G><R><A><G><H><V><V><C><R><V><D><P><G><T><S><A><Q><R><Q><G><L><Q><E><G><D><R><I><L><A><V><N><N><D><V><V><E><H><E><D><Y><A><V><V><V><R><R><I><R><A><S><S><P><R><V><L><L><T><V><L><A><R><H><A><H><D><V><A><R><A><Q><L><G><E><D><A><H><L><C><P><T><L><G><P><G><V><R><P><R><L><C><H><I><V><K><D><E><G><G><F><G><F><S><V><T><H><G><N><Q><G><P><F><W><L><V><L><S><T><G><G><A><A><E><R><A><G><V><P><P><G><A><R><L><L><E><V><N><G><V><S><V><E><K><F><T><H><N><Q><L><T><R><K><L><W><Q><S><G><Q><Q><V><T><L><L><V><A><G><P><E><V><E><E><Q><C><R><Q><L><G><L><P><L><A><A><P><L><A><E><G><W><A><L><P><T><K><P><R><C><L><H><L><E><K><G><P><Q><G><F><G><F><L><L><R><E><E><K><G><L><D><G><R><P><G><Q><F><L><W><E><V><D><P><G><L><P><A><K><K><A><G><M><Q><A><G><D><R><L><V><A><V><A><G><E><S><V><E><G><L><G><H><E><E><T><V><S><R><I><Q><G><Q><G><S><C><V><S><L><T><V><V><D><P><E><A><D><R><F><F><S><M><V><R><L><S><P><L><L><F><L><E><N><T><E><A><P><A><S><P><R><G><S><S><S><A><S><L><V><E><T><E><D><P><S><L><E><D><T><S><V><P><S><V><P><L><G><S><R><Q><C><F><L><Y><P><G><P><G><G><S><Y><G><F><R><L><S><C><V><A><S><G><P><R><L><F><I><S><Q><V><T><P><G><G><S><A><A><R><A><G><L><Q><V><G><D><V><I><L><E><V><N><G><Y><P><V><G><G><Q><N><D><L><E><R><L><Q><Q><L><P><E><A><E><P><P><L><C><L><K><L><A><A><R><S><L><R><G><L><E><A><W><I><P><P><G><A><A><E><D><W><A><L><A><S><D><L><L>
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Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation . Stimulates SLC9A3 activity in the presence of elevated calcium ions .<BOP>
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Q86UT5
|
Q15785
|
TOM34_HUMAN
|
Translocase of outer membrane 34 kDa subunit
|
Homo
|
<M><A><P><K><F><P><D><S><V><E><E><L><R><A><A><G><N><E><S><F><R><N><G><Q><Y><A><E><A><S><A><L><Y><G><R><A><L><R><V><L><Q><A><Q><G><S><S><D><P><E><E><E><S><V><L><Y><S><N><R><A><A><C><H><L><K><D><G><N><C><R><D><C><I><K><D><C><T><S><A><L><A><L><V><P><F><S><I><K><P><L><L><R><R><A><S><A><Y><E><A><L><E><K><Y><P><M><A><Y><V><D><Y><K><T><V><L><Q><I><D><D><N><V><T><S><A><V><E><G><I><N><R><M><T><R><A><L><M><D><S><L><G><P><E><W><R><L><K><L><P><S><I><P><L><V><P><V><S><A><Q><K><R><W><N><S><L><P><S><E><N><H><K><E><M><A><K><S><K><S><K><E><T><T><A><T><K><N><R><V><P><S><A><G><D><V><E><K><A><R><V><L><K><E><E><G><N><E><L><V><K><K><G><N><H><K><K><A><I><E><K><Y><S><E><S><L><L><C><S><N><L><E><S><A><T><Y><S><N><R><A><L><C><Y><L><V><L><K><Q><Y><T><E><A><V><K><D><C><T><E><A><L><K><L><D><G><K><N><V><K><A><F><Y><R><R><A><Q><A><H><K><A><L><K><D><Y><K><S><S><F><A><D><I><S><N><L><L><Q><I><E><P><R><N><G><P><A><Q><K><L><R><Q><E><V><K><Q><N><L><H>
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Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.<BOP>
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Q15785
|
P36894
|
BMR1A_HUMAN
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Serine/threonine-protein kinase receptor R5
|
Homo
|
<M><P><Q><L><Y><I><Y><I><R><L><L><G><A><Y><L><F><I><I><S><R><V><Q><G><Q><N><L><D><S><M><L><H><G><T><G><M><K><S><D><S><D><Q><K><K><S><E><N><G><V><T><L><A><P><E><D><T><L><P><F><L><K><C><Y><C><S><G><H><C><P><D><D><A><I><N><N><T><C><I><T><N><G><H><C><F><A><I><I><E><E><D><D><Q><G><E><T><T><L><A><S><G><C><M><K><Y><E><G><S><D><F><Q><C><K><D><S><P><K><A><Q><L><R><R><T><I><E><C><C><R><T><N><L><C><N><Q><Y><L><Q><P><T><L><P><P><V><V><I><G><P><F><F><D><G><S><I><R><W><L><V><L><L><I><S><M><A><V><C><I><I><A><M><I><I><F><S><S><C><F><C><Y><K><H><Y><C><K><S><I><S><S><R><R><R><Y><N><R><D><L><E><Q><D><E><A><F><I><P><V><G><E><S><L><K><D><L><I><D><Q><S><Q><S><S><G><S><G><S><G><L><P><L><L><V><Q><R><T><I><A><K><Q><I><Q><M><V><R><Q><V><G><K><G><R><Y><G><E><V><W><M><G><K><W><R><G><E><K><V><A><V><K><V><F><F><T><T><E><E><A><S><W><F><R><E><T><E><I><Y><Q><T><V><L><M><R><H><E><N><I><L><G><F><I><A><A><D><I><K><G><T><G><S><W><T><Q><L><Y><L><I><T><D><Y><H><E><N><G><S><L><Y><D><F><L><K><C><A><T><L><D><T><R><A><L><L><K><L><A><Y><S><A><A><C><G><L><C><H><L><H><T><E><I><Y><G><T><Q><G><K><P><A><I><A><H><R><D><L><K><S><K><N><I><L><I><K><K><N><G><S><C><C><I><A><D><L><G><L><A><V><K><F><N><S><D><T><N><E><V><D><V><P><L><N><T><R><V><G><T><K><R><Y><M><A><P><E><V><L><D><E><S><L><N><K><N><H><F><Q><P><Y><I><M><A><D><I><Y><S><F><G><L><I><I><W><E><M><A><R><R><C><I><T><G><G><I><V><E><E><Y><Q><L><P><Y><Y><N><M><V><P><S><D><P><S><Y><E><D><M><R><E><V><V><C><V><K><R><L><R><P><I><V><S><N><R><W><N><S><D><E><C><L><R><A><V><L><K><L><M><S><E><C><W><A><H><N><P><A><S><R><L><T><A><L><R><I><K><K><T><L><A><K><M><V><E><S><Q><D><V><K><I>
|
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.<BOP>
|
P36894
|
O94776
|
MTA2_HUMAN
|
p53 target protein in deacetylase complex
|
Homo
|
<M><A><A><N><M><Y><R><V><G><D><Y><V><Y><F><E><N><S><S><S><N><P><Y><L><V><R><R><I><E><E><L><N><K><T><A><N><G><N><V><E><A><K><V><V><C><L><F><R><R><R><D><I><S><S><S><L><N><S><L><A><D><S><N><A><R><E><F><E><E><E><S><K><Q><P><G><V><S><E><Q><Q><R><H><Q><L><K><H><R><E><L><F><L><S><R><Q><F><E><S><L><P><A><T><H><I><R><G><K><C><S><V><T><L><L><N><E><T><D><I><L><S><Q><Y><L><E><K><E><D><C><F><F><Y><S><L><V><F><D><P><V><Q><K><T><L><L><A><D><Q><G><E><I><R><V><G><C><K><Y><Q><A><E><I><P><D><R><L><V><E><G><E><S><D><N><R><N><Q><Q><K><M><E><M><K><V><W><D><P><D><N><P><L><T><D><R><Q><I><D><Q><F><L><V><V><A><R><A><V><G><T><F><A><R><A><L><D><C><S><S><S><I><R><Q><P><S><L><H><M><S><A><A><A><A><S><R><D><I><T><L><F><H><A><M><D><T><L><Q><R><N><G><Y><D><L><A><K><A><M><S><T><L><V><P><Q><G><G><P><V><L><C><R><D><E><M><E><E><W><S><A><S><E><A><M><L><F><E><E><A><L><E><K><Y><G><K><D><F><N><D><I><R><Q><D><F><L><P><W><K><S><L><A><S><I><V><Q><F><Y><Y><M><W><K><T><T><D><R><Y><I><Q><Q><K><R><L><K><A><A><E><A><D><S><K><L><K><Q><V><Y><I><P><T><Y><T><K><P><N><P><N><Q><I><I><S><V><G><S><K><P><G><M><N><G><A><G><F><Q><K><G><L><T><C><E><S><C><H><T><T><Q><S><A><Q><W><Y><A><W><G><P><P><N><M><Q><C><R><L><C><A><S><C><W><I><Y><W><K><K><Y><G><G><L><K><T><P><T><Q><L><E><G><A><T><R><G><T><T><E><P><H><S><R><G><H><L><S><R><P><E><A><Q><S><L><S><P><Y><T><T><S><A><N><R><A><K><L><L><A><K><N><R><Q><T><F><L><L><Q><T><T><K><L><T><R><L><A><R><R><M><C><R><D><L><L><Q><P><R><R><A><A><R><R><P><Y><A><P><I><N><A><N><A><I><K><A><E><C><S><I><R><L><P><K><A><A><K><T><P><L><K><I><H><P><L><V><R><L><P><L><A><T><I><V><K><D><L><V><A><Q><A><P><L><K><P><K><T><P><R><G><T><K><T><P><I><N><R><N><Q><L><S><Q><N><R><G><L><G><G><I><M><V><K><R><A><Y><E><T><M><A><G><A><G><V><P><F><S><A><N><G><R><P><L><A><S><G><I><R><S><S><S><Q><P><A><A><K><R><Q><K><L><N><P><A><D><A><P><N><P><V><V><F><V><A><T><K><D><T><R><A><L><R><K><A><L><T><H><L><E><M><R><R><A><A><R><R><P><N><L><P><L><K><V><K><P><T><L><I><A><V><R><P><P><V><P><L><P><A><P><S><H><P><A><S><T><N><E><P><I><V><L><E><D>
|
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.<BOP>
|
O94776
|
P11413
|
G6PD_HUMAN
|
Glucose-6-phosphate 1-dehydrogenase
|
Homo
|
<M><A><E><Q><V><A><L><S><R><T><Q><V><C><G><I><L><R><E><E><L><F><Q><G><D><A><F><H><Q><S><D><T><H><I><F><I><I><M><G><A><S><G><D><L><A><K><K><K><I><Y><P><T><I><W><W><L><F><R><D><G><L><L><P><E><N><T><F><I><V><G><Y><A><R><S><R><L><T><V><A><D><I><R><K><Q><S><E><P><F><F><K><A><T><P><E><E><K><L><K><L><E><D><F><F><A><R><N><S><Y><V><A><G><Q><Y><D><D><A><A><S><Y><Q><R><L><N><S><H><M><N><A><L><H><L><G><S><Q><A><N><R><L><F><Y><L><A><L><P><P><T><V><Y><E><A><V><T><K><N><I><H><E><S><C><M><S><Q><I><G><W><N><R><I><I><V><E><K><P><F><G><R><D><L><Q><S><S><D><R><L><S><N><H><I><S><S><L><F><R><E><D><Q><I><Y><R><I><D><H><Y><L><G><K><E><M><V><Q><N><L><M><V><L><R><F><A><N><R><I><F><G><P><I><W><N><R><D><N><I><A><C><V><I><L><T><F><K><E><P><F><G><T><E><G><R><G><G><Y><F><D><E><F><G><I><I><R><D><V><M><Q><N><H><L><L><Q><M><L><C><L><V><A><M><E><K><P><A><S><T><N><S><D><D><V><R><D><E><K><V><K><V><L><K><C><I><S><E><V><Q><A><N><N><V><V><L><G><Q><Y><V><G><N><P><D><G><E><G><E><A><T><K><G><Y><L><D><D><P><T><V><P><R><G><S><T><T><A><T><F><A><A><V><V><L><Y><V><E><N><E><R><W><D><G><V><P><F><I><L><R><C><G><K><A><L><N><E><R><K><A><E><V><R><L><Q><F><H><D><V><A><G><D><I><F><H><Q><Q><C><K><R><N><E><L><V><I><R><V><Q><P><N><E><A><V><Y><T><K><M><M><T><K><K><P><G><M><F><F><N><P><E><E><S><E><L><D><L><T><Y><G><N><R><Y><K><N><V><K><L><P><D><A><Y><E><R><L><I><L><D><V><F><C><G><S><Q><M><H><F><V><R><S><D><E><L><R><E><A><W><R><I><F><T><P><L><L><H><Q><I><E><L><E><K><P><K><P><I><P><Y><I><Y><G><S><R><G><P><T><E><A><D><E><L><M><K><R><V><G><F><Q><Y><E><G><T><Y><K><W><V><N><P><H><K><L>
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Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.<BOP>
|
P11413
|
Q9NQ25
|
SLAF7_HUMAN
|
Protein 19A
|
Homo
|
<M><A><G><S><P><T><C><L><T><L><I><Y><I><L><W><Q><L><T><G><S><A><A><S><G><P><V><K><E><L><V><G><S><V><G><G><A><V><T><F><P><L><K><S><K><V><K><Q><V><D><S><I><V><W><T><F><N><T><T><P><L><V><T><I><Q><P><E><G><G><T><I><I><V><T><Q><N><R><N><R><E><R><V><D><F><P><D><G><G><Y><S><L><K><L><S><K><L><K><K><N><D><S><G><I><Y><Y><V><G><I><Y><S><S><S><L><Q><Q><P><S><T><Q><E><Y><V><L><H><V><Y><E><H><L><S><K><P><K><V><T><M><G><L><Q><S><N><K><N><G><T><C><V><T><N><L><T><C><C><M><E><H><G><E><E><D><V><I><Y><T><W><K><A><L><G><Q><A><A><N><E><S><H><N><G><S><I><L><P><I><S><W><R><W><G><E><S><D><M><T><F><I><C><V><A><R><N><P><V><S><R><N><F><S><S><P><I><L><A><R><K><L><C><E><G><A><A><D><D><P><D><S><S><M><V><L><L><C><L><L><L><V><P><L><L><L><S><L><F><V><L><G><L><F><L><W><F><L><K><R><E><R><Q><E><E><Y><I><E><E><K><K><R><V><D><I><C><R><E><T><P><N><I><C><P><H><S><G><E><N><T><E><Y><D><T><I><P><H><T><N><R><T><I><L><K><E><D><P><A><N><T><V><Y><S><T><V><E><I><P><K><K><M><E><N><P><H><S><L><L><T><M><P><D><T><P><R><L><F><A><Y><E><N><V><I>
|
Isoform 3 does not mediate any NK cell activation.<BOP>
|
Q9NQ25
|
P48448
|
AL3B2_HUMAN
|
Aldehyde dehydrogenase 8
|
Homo
|
<M><K><D><E><P><R><S><T><N><L><F><M><K><L><D><S><V><F><I><W><K><E><P><F><G><L><V><L><I><I><A><P><W><N><Y><P><L><N><L><T><L><V><L><L><V><G><A><L><A><A><G><S><C><V><V><L><K><P><S><E><I><S><Q><G><T><E><K><V><L><A><E><V><L><P><Q><Y><L><D><Q><S><C><F><A><V><V><L><G><G><P><Q><E><T><G><Q><L><L><E><H><K><L><D><Y><I><F><F><T><G><S><P><R><V><G><K><I><V><M><T><A><A><T><K><H><L><T><P><V><T><L><E><L><G><G><K><N><P><C><Y><V><D><D><N><C><D><P><Q><T><V><A><N><R><V><A><W><F><C><Y><F><N><A><G><Q><T><C><V><A><P><D><Y><V><L><C><S><P><E><M><Q><E><R><L><L><P><A><L><Q><S><T><I><T><R><F><Y><G><D><D><P><Q><S><S><P><N><L><G><H><I><I><N><Q><K><Q><F><Q><R><L><R><A><L><L><G><C><S><R><V><A><I><G><G><Q><S><N><E><S><D><R><Y><I><A><P><T><V><L><V><D><V><Q><E><T><E><P><V><M><Q><E><E><I><F><G><P><I><L><P><I><V><N><V><Q><S><V><D><E><A><I><K><F><I><N><R><Q><E><K><P><L><A><L><Y><A><F><S><N><S><S><Q><V><V><N><Q><M><L><E><R><T><S><S><G><S><F><G><G><N><E><G><F><T><Y><I><S><L><L><S><V><P><F><G><G><V><G><H><S><G><M><G><R><Y><H><G><K><F><T><F><D><T><F><S><H><H><R><T><C><L><L><A><P><S><G><L><E><K><L><K><E><I><H><Y><P><P><Y><T><D><W><N><Q><Q><L><L><R><W><G><M><G><S><Q><S><C><T><L><L>
|
Oxidizes medium and long chain aldehydes into non-toxic fatty acids.<BOP>
|
P48448
|
O75628
|
REM1_HUMAN
|
Rad and Gem-like GTP-binding protein 1
|
Homo
|
<M><T><L><N><T><E><Q><E><A><K><T><P><L><H><R><R><A><S><T><P><L><P><L><S><P><R><G><H><Q><P><G><R><L><S><T><V><P><S><T><Q><S><Q><H><P><R><L><G><Q><S><A><S><L><N><P><P><T><Q><K><P><S><P><A><P><D><D><W><S><S><E><S><S><D><S><E><G><S><W><E><A><L><Y><R><V><V><L><L><G><D><P><G><V><G><K><T><S><L><A><S><L><F><A><G><K><Q><E><R><D><L><H><E><Q><L><G><E><D><V><Y><E><R><T><L><T><V><D><G><E><D><T><T><L><V><V><V><D><T><W><E><A><E><K><L><D><K><S><W><S><Q><E><S><C><L><Q><G><G><S><A><Y><V><I><V><Y><S><I><A><D><R><G><S><F><E><S><A><S><E><L><R><I><Q><L><R><R><T><H><Q><A><D><H><V><P><I><I><L><V><G><N><K><A><D><L><A><R><C><R><E><V><S><V><E><E><G><R><A><C><A><V><V><F><D><C><K><F><I><E><T><S><A><T><L><Q><H><N><V><A><E><L><F><E><G><V><V><R><Q><L><R><L><R><R><R><D><S><A><A><K><E><P><P><A><P><R><R><P><A><S><L><A><Q><R><A><R><R><F><L><A><R><L><T><A><R><S><A><R><R><R><A><L><K><A><R><S><K><S><C><H><N><L><A><V><L>
|
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.<BOP>
|
O75628
|
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