accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q96D59 | RN183_HUMAN | E3 ubiquitin-protein ligase RNF183 | Homo | <M><A><E><Q><Q><G><R><E><L><E><A><E><C><P><V><C><W><N><P><F><N><N><T><F><H><T><P><K><M><L><D><C><C><H><S><F><C><V><E><C><L><A><H><L><S><L><V><T><P><A><R><R><R><L><L><C><P><L><C><R><Q><P><T><V><L><A><S><G><Q><P><V><T><D><L><P><T><D><T><A><M><L><A><L><L><R><L><E><P><H><H><V><I><L><E><G><H><Q><L><C><L><K><D><Q><P><K><S><R... | Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 . May collaborate with FATE1 to restrain BIK protein levels thus reg... | Q96D59 |
Q9NXG2 | THUM1_HUMAN | THUMP domain-containing protein 1 | Homo | <M><A><A><P><A><Q><Q><T><T><Q><P><G><G><G><K><R><K><G><K><A><Q><Y><V><L><A><K><R><A><R><R><C><D><A><G><G><P><R><Q><L><E><P><G><L><Q><G><I><L><I><T><C><N><M><N><E><R><K><C><V><E><E><A><Y><S><L><L><N><E><Y><G><D><D><M><Y><G><P><E><K><F><T><D><K><D><Q><Q><P><S><G><S><E><G><E><D><D><D><A><E><A><A><L><K><K><E><V><G><D><I><K... | Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation .<BOP> | Q9NXG2 |
Q8TDU9 | RL3R2_HUMAN | Relaxin family peptide receptor 4 | Homo | <M><P><T><L><N><T><S><A><S><P><P><T><F><F><W><A><N><A><S><G><G><S><V><L><S><A><D><D><A><P><M><P><V><K><F><L><A><L><R><L><M><V><A><L><A><Y><G><L><V><G><A><I><G><L><L><G><N><L><A><V><L><W><V><L><S><N><C><A><R><R><A><P><G><P><P><S><D><T><F><V><F><N><L><A><L><A><D><L><G><L><A><L><T><L><P><F><W><A><A><E><S><A><L><D><F><H><W... | High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.<BOP> | Q8TDU9 |
Q9UKU9 | ANGL2_HUMAN | Angiopoietin-like protein 2 | Homo | <M><R><P><L><C><V><T><C><W><W><L><G><L><L><A><A><M><G><A><V><A><G><Q><E><D><G><F><E><G><T><E><E><G><S><P><R><E><F><I><Y><L><N><R><Y><K><R><A><G><E><S><Q><D><K><C><T><Y><T><F><I><V><P><Q><Q><R><V><T><G><A><I><C><V><N><S><K><E><P><E><V><L><L><E><N><R><V><H><K><Q><E><L><E><L><L><N><N><E><L><L><K><Q><K><R><Q><I><E><T><L><Q... | Induces sprouting in endothelial cells through an autocrine and paracrine action.<BOP> | Q9UKU9 |
Q6P1L6 | ZN343_HUMAN | Zinc finger protein 343 | Homo | <M><M><L><P><Y><P><S><A><L><G><D><Q><Y><W><E><E><I><L><L><P><K><N><G><E><N><V><E><T><M><K><K><L><T><Q><N><H><K><A><K><G><L><P><S><N><D><T><D><C><P><Q><K><K><E><G><K><A><Q><I><V><V><P><V><T><F><R><D><V><T><V><I><F><T><E><A><E><W><K><R><L><S><P><E><Q><R><N><L><Y><K><E><V><M><L><E><N><Y><R><N><L><L><S><L><A><E><P><K><P><E... | May be involved in transcriptional regulation.<BOP> | Q6P1L6 |
Q9UI14 | PRAF1_HUMAN | PRA1 family protein 1 | Homo | <M><A><A><Q><K><D><Q><Q><K><D><A><E><A><E><G><L><S><G><T><T><L><L><P><K><L><I><P><S><G><A><G><R><E><W><L><E><R><R><R><A><T><I><R><P><W><S><T><F><V><D><Q><Q><R><F><S><R><P><R><N><L><G><E><L><C><Q><R><L><V><R><N><V><E><Y><Y><Q><S><N><Y><V><F><V><F><L><G><L><I><L><Y><C><V><V><T><S><P><M><L><L><V><A><L><A><V><F><F><G><A><C... | General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.<BOP> | Q9UI14 |
P78334 | GBRE_HUMAN | GABA(A) receptor subunit epsilon | Homo | <M><L><S><K><V><L><P><V><L><L><G><I><L><L><I><L><Q><S><R><V><E><G><P><Q><T><E><S><K><N><E><A><S><S><R><D><V><V><Y><G><P><Q><P><Q><P><L><E><N><Q><L><L><S><E><E><T><K><S><T><E><T><E><T><G><S><R><V><G><K><L><P><E><A><S><R><I><L><N><T><I><L><S><N><Y><D><H><K><L><R><P><G><I><G><E><K><P><T><V><V><T><V><E><I><S><V><N><S><L><G... | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP> | P78334 |
Q14790 | CASP8_HUMAN | Caspase-8 subunit p10 | Homo | <M><D><F><S><R><N><L><Y><D><I><G><E><Q><L><D><S><E><D><L><A><S><L><K><F><L><S><L><D><Y><I><P><Q><R><K><Q><E><P><I><K><D><A><L><M><L><F><Q><R><L><Q><E><K><R><M><L><E><E><S><N><L><S><F><L><K><E><L><L><F><R><I><N><R><L><D><L><L><I><T><Y><L><N><T><R><K><E><E><M><E><R><E><L><Q><T><P><G><R><A><Q><I><S><A><Y><R><V><M><L><Y><Q... | Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex.<BOP> | Q14790 |
Q14393 | GAS6_HUMAN | AXL receptor tyrosine kinase ligand | Homo | <M><A><P><S><L><S><P><G><P><A><A><L><R><R><A><P><Q><L><L><L><L><L><L><A><A><E><C><A><L><A><A><L><L><P><A><R><E><A><T><Q><F><L><R><P><R><Q><R><R><A><F><Q><V><F><E><E><A><K><Q><G><H><L><E><R><E><C><V><E><E><L><C><S><R><E><E><A><R><E><V><F><E><N><D><P><E><T><D><Y><F><Y><P><R><Y><L><D><C><I><N><K><Y><G><S><P><Y><T><K><N><S... | (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry . Plays a role in Dengue cell entry by apoptotic mimicry . Plays a role in Vaccinia virus cell entry by apoptotic mimicry . Plays a role in ebolavirus and marburgvirus c... | Q14393 |
Q9UG22 | GIMA2_HUMAN | Immunity-associated protein 2 | Homo | <M><D><Q><N><E><H><S><H><W><G><P><H><A><K><G><Q><C><A><S><R><S><E><L><R><I><I><L><V><G><K><T><G><T><G><K><S><A><A><G><N><S><I><L><R><K><Q><A><F><E><S><K><L><G><S><Q><T><L><T><K><T><C><S><K><S><Q><G><S><W><G><N><R><E><I><V><I><I><D><T><P><D><M><F><S><W><K><D><H><C><E><A><L><Y><K><E><V><Q><R><C><Y><L><L><S><A><P><G><P><H... | The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.<BOP> | Q9UG22 |
O60479 | DLX3_HUMAN | Homeobox protein DLX-3 | Homo | <M><S><G><S><F><D><R><K><L><S><S><I><L><T><D><I><S><S><S><L><S><C><H><A><G><S><K><D><S><P><T><L><P><E><S><S><V><T><D><L><G><Y><Y><S><A><P><Q><H><D><Y><Y><S><G><Q><P><Y><G><Q><T><V><N><P><Y><T><Y><H><H><Q><F><N><L><N><G><L><A><G><T><G><A><Y><S><P><K><S><E><Y><T><Y><G><A><S><Y><R><Q><Y><G><A><Y><R><E><Q><P><L><P><A><Q><D... | Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.<BOP> | O60479 |
Q8WW27 | ABEC4_HUMAN | Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4 | Homo | <M><E><P><I><Y><E><E><Y><L><A><N><H><G><T><I><V><K><P><Y><Y><W><L><S><F><S><L><D><C><S><N><C><P><Y><H><I><R><T><G><E><E><A><R><V><S><L><T><E><F><C><Q><I><F><G><F><P><Y><G><T><T><F><P><Q><T><K><H><L><T><F><Y><E><L><K><T><S><S><G><S><L><V><Q><K><G><H><A><S><S><C><T><G><N><Y><I><H><P><E><S><M><L><F><E><M><N><G><Y><L><D><S... | Putative C to U editing enzyme whose physiological substrate is not yet known.<BOP> | Q8WW27 |
Q96IL0 | COA8_HUMAN | Apoptogenic protein 1, mitochondrial | Homo | <M><L><P><C><A><A><G><A><R><G><R><G><A><M><V><V><L><R><A><G><K><K><T><F><L><P><P><L><C><R><A><F><A><C><R><G><C><Q><L><A><P><E><R><G><A><E><R><R><D><T><A><P><S><G><V><S><R><F><C><P><P><R><K><S><C><H><D><W><I><G><P><P><D><K><Y><S><N><L><R><P><V><H><F><Y><I><P><E><N><E><S><P><L><E><Q><K><L><R><K><L><R><Q><E><T><Q><E><W><N... | Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.<BOP> | Q96IL0 |
Q8WTV0 | SCRB1_HUMAN | SR-BI | Homo | <M><G><C><S><A><K><A><R><W><A><A><G><A><L><G><V><A><G><L><L><C><A><V><L><G><A><V><M><I><V><M><V><P><S><L><I><K><Q><Q><V><L><K><N><V><R><I><D><P><S><S><L><S><F><N><M><W><K><E><I><P><I><P><F><Y><L><S><V><Y><F><F><D><V><M><N><P><S><E><I><L><K><G><E><K><P><Q><V><R><E><R><G><P><Y><V><Y><R><E><F><R><H><K><S><N><I><T><F><N><N... | (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.<BOP> | Q8WTV0 |
P55107 | GDF10_HUMAN | Bone-inducing protein | Homo | <M><A><H><V><P><A><R><T><S><P><G><P><G><P><Q><L><L><L><L><L><L><P><L><F><L><L><L><L><R><D><V><A><G><S><H><R><A><P><A><W><S><A><L><P><A><A><A><D><G><L><Q><G><D><R><D><L><Q><R><H><P><G><D><A><A><A><T><L><G><P><S><A><Q><D><M><V><A><V><H><M><H><R><L><Y><E><K><Y><S><R><Q><G><A><R><P><G><G><G><N><T><V><R><S><F><R><A><R><L><E... | Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.<BOP> | P55107 |
Q8NA47 | CCD63_HUMAN | Coiled-coil domain-containing protein 63 | Homo | <M><S><V><L><K><K><N><R><R><K><D><S><D><T><P><Q><E><P><S><E><K><A><K><E><Q><Q><A><E><A><E><L><R><K><L><R><Q><Q><F><R><K><M><V><E><S><R><K><S><F><K><F><R><N><Q><Q><K><I><A><S><Q><Y><K><E><I><K><T><L><K><T><E><Q><D><E><I><T><L><L><L><S><L><M><K><S><S><R><N><M><N><R><S><E><K><N><Y><M><E><L><R><L><L><L><Q><T><K><E><D><Y><E... | Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.<BOP> | Q8NA47 |
Q99675 | CGRF1_HUMAN | RING finger protein 197 | Homo | <M><A><A><V><F><L><V><T><L><Y><E><Y><S><P><L><F><Y><I><A><V><V><F><T><C><F><I><V><T><T><G><L><V><L><G><W><F><G><W><D><V><P><V><I><L><R><N><S><E><E><T><Q><F><S><T><R><V><F><K><K><Q><M><R><Q><V><K><N><P><F><G><L><E><I><T><N><P><S><S><A><S><I><T><T><G><I><T><L><T><T><D><C><L><E><D><S><L><L><T><C><Y><W><G><C><S><V><Q><K><L... | Able to inhibit growth in several cell lines.<BOP> | Q99675 |
Q9H2R5 | KLK15_HUMAN | ACO protease | Homo | <M><W><L><L><L><T><L><S><F><L><L><A><S><T><A><A><Q><D><G><D><K><L><L><E><G><D><E><C><A><P><H><S><Q><P><W><Q><V><A><L><Y><E><R><G><R><F><N><C><G><A><S><L><I><S><P><H><W><V><L><S><A><A><H><C><Q><S><R><F><M><R><V><R><L><G><E><H><N><L><R><K><R><D><G><P><E><Q><L><R><T><T><S><R><V><I><P><H><P><R><Y><E><A><R><S><H><R><N><D><I... | Protease whose physiological substrate is not yet known.<BOP> | Q9H2R5 |
P51398 | RT29_HUMAN | Mitochondrial small ribosomal subunit protein mS29 | Homo | <M><M><L><K><G><I><T><R><L><I><S><R><I><H><K><L><D><P><G><R><F><L><H><M><G><T><Q><A><R><Q><S><I><A><A><H><L><D><N><Q><V><P><V><E><S><P><R><A><I><S><R><T><N><E><N><D><P><A><K><H><G><D><Q><H><E><G><Q><H><Y><N><I><S><P><Q><D><L><E><T><V><F><P><H><G><L><P><P><R><F><V><M><Q><V><K><T><F><S><E><A><C><L><M><V><R><K><P><A><L><E... | Involved in mediating interferon-gamma-induced cell death.<BOP> | P51398 |
Q8WU76 | SCFD2_HUMAN | Syntaxin-binding protein 1-like 1 | Homo | <M><S><A><S><G><V><L><S><F><T><Q><Q><G><W><E><Q><V><L><A><K><V><K><R><A><V><V><Y><L><D><A><A><C><A><E><S><L><H><W><G><C><G><S><T><R><L><L><E><A><V><G><G><P><D><C><H><L><R><E><F><E><P><D><A><I><G><G><G><A><K><Q><P><K><A><V><F><V><L><S><C><L><L><K><G><R><T><V><E><I><L><R><D><I><I><C><R><S><H><F><Q><Y><C><V><V><V><T><T><V... | May be involved in protein transport.<BOP> | Q8WU76 |
Q96S94 | CCNL2_HUMAN | Paneth cell-enhanced expression protein | Homo | <M><A><A><A><A><A><A><A><G><A><A><G><S><A><A><P><A><A><A><A><G><A><P><G><S><G><G><A><P><S><G><S><Q><G><V><L><I><G><D><R><L><Y><S><G><V><L><I><T><L><E><N><C><L><L><P><D><D><K><L><R><F><T><P><S><M><S><S><G><L><D><T><D><T><E><T><D><L><R><V><V><G><C><E><L><I><Q><A><A><G><I><L><L><R><L><P><Q><V><A><M><A><T><G><Q><V><L><F><Q... | Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.<BOP> | Q96S94 |
Q08ER8 | ZN543_HUMAN | Zinc finger protein 543 | Homo | <M><A><A><S><A><Q><V><S><V><T><F><E><D><V><A><V><T><F><T><Q><E><E><W><G><Q><L><D><A><A><Q><R><T><L><Y><Q><E><V><M><L><E><T><C><G><L><L><M><S><L><G><C><P><L><F><K><P><E><L><I><Y><Q><L><D><H><R><Q><E><L><W><M><A><T><K><D><L><S><Q><S><S><Y><P><G><D><N><T><K><P><K><T><T><E><P><T><F><S><H><L><A><L><P><E><E><V><L><L><Q><E><Q... | May be involved in transcriptional regulation.<BOP> | Q08ER8 |
Q13564 | ULA1_HUMAN | Proto-oncogene protein 1 | Homo | <M><A><Q><L><G><K><L><L><K><E><Q><K><Y><D><R><Q><L><R><L><W><G><D><H><G><Q><E><A><L><E><S><A><H><V><C><L><I><N><A><T><A><T><G><T><E><I><L><K><N><L><V><L><P><G><I><G><S><F><T><I><I><D><G><N><Q><V><S><G><E><D><A><G><N><N><F><F><L><Q><R><S><S><I><G><K><N><R><A><E><A><A><M><E><F><L><Q><E><L><N><S><D><V><S><G><S><F><V><E><E... | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M... | Q13564 |
Q8NHB7 | OR5K1_HUMAN | Olfactory receptor OR3-8 | Homo | <M><A><E><E><N><H><T><M><K><N><E><F><I><L><T><G><F><T><D><H><P><E><L><K><T><L><L><F><V><V><F><F><A><I><Y><L><I><T><V><V><G><N><I><S><L><V><A><L><I><F><T><H><R><R><L><H><T><P><M><Y><I><F><L><G><N><L><A><L><V><D><S><C><C><A><C><A><I><T><P><K><M><L><E><N><F><F><S><E><N><K><R><I><S><L><Y><E><C><A><V><Q><F><Y><F><L><C><T><V... | Odorant receptor.<BOP> | Q8NHB7 |
Q8NCE2 | MTMRE_HUMAN | hJumpy | Homo | <M><A><G><A><R><A><A><A><A><A><A><S><A><G><S><S><A><S><S><G><N><Q><P><P><Q><E><L><G><L><G><E><L><L><E><E><F><S><R><T><Q><Y><R><A><K><D><G><S><G><T><G><G><S><K><V><E><R><I><E><K><R><C><L><E><L><F><G><R><D><Y><C><F><S><V><I><P><N><T><N><G><D><I><C><G><H><Y><P><R><H><I><V><F><L><E><Y><E><S><S><E><K><E><K><D><T><F><E><S><T... | Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.<BOP> | Q8NCE2 |
Q9H7L9 | SDS3_HUMAN | Suppressor of defective silencing 3 protein homolog | Homo | <M><S><A><A><G><L><L><A><P><A><P><A><Q><A><G><A><P><P><A><P><E><Y><Y><P><E><E><D><E><E><L><E><S><A><E><D><D><E><R><S><C><R><G><R><E><S><D><E><D><T><E><D><A><S><E><T><D><L><A><K><H><D><E><E><D><Y><V><E><M><K><E><Q><M><Y><Q><D><K><L><A><S><L><K><R><Q><L><Q><Q><L><Q><E><G><T><L><Q><E><Y><Q><K><R><M><K><K><L><D><Q><Q><Y><K... | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the c... | Q9H7L9 |
Q6UX07 | DHR13_HUMAN | Short chain dehydrogenase/reductase family 7C member 5 | Homo | <M><E><A><L><L><L><G><A><G><L><L><L><G><A><Y><V><L><V><Y><Y><N><L><V><K><A><P><P><C><G><G><M><G><N><L><R><G><R><T><A><V><V><T><G><A><N><S><G><I><G><K><M><T><A><L><E><L><A><R><R><G><A><R><V><V><L><A><C><R><S><Q><E><R><G><E><A><A><A><F><D><L><R><Q><E><S><G><N><N><E><V><I><F><M><A><L><D><L><A><S><L><A><S><V><R><A><F><A><T... | Putative oxidoreductase.<BOP> | Q6UX07 |
P56749 | CLD12_HUMAN | Claudin-12 | Homo | <M><G><C><R><D><V><H><A><A><T><V><L><S><F><L><C><G><I><A><S><V><A><G><L><F><A><G><T><L><L><P><N><W><R><K><L><R><L><I><T><F><N><R><N><E><K><N><L><T><V><Y><T><G><L><W><V><K><C><A><R><Y><D><G><S><S><D><C><L><M><Y><D><T><T><W><Y><S><S><V><D><Q><L><D><L><R><V><L><Q><F><A><L><P><L><S><M><L><I><A><M><G><A><L><L><L><C><L><I><G... | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP> | P56749 |
P26368 | U2AF2_HUMAN | U2 snRNP auxiliary factor large subunit | Homo | <M><S><D><F><D><E><F><E><R><Q><L><N><E><N><K><Q><E><R><D><K><E><N><R><H><R><K><R><S><H><S><R><S><R><S><R><D><R><K><R><R><S><R><S><R><D><R><R><N><R><D><Q><R><S><A><S><R><D><R><R><R><R><S><K><P><L><T><R><G><A><K><E><E><H><G><G><L><I><R><S><P><R><H><E><K><K><K><K><V><R><K><Y><W><D><V><P><P><P><G><F><E><H><I><T><P><M><Q><Y... | Plays a role in pre-mRNA splicing and 3'-end processing . By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing . Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates ... | P26368 |
P56696 | KCNQ4_HUMAN | Voltage-gated potassium channel subunit Kv7.4 | Homo | <M><A><E><A><P><P><R><R><L><G><L><G><P><P><P><G><D><A><P><R><A><E><L><V><A><L><T><A><V><Q><S><E><Q><G><E><A><G><G><G><G><S><P><R><R><L><G><L><L><G><S><P><L><P><P><G><A><P><L><P><G><P><G><S><G><S><G><S><A><C><G><Q><R><S><S><A><A><H><K><R><Y><R><R><L><Q><N><W><V><Y><N><V><L><E><R><P><R><G><W><A><F><V><Y><H><V><F><I><F><L... | Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strong... | P56696 |
Q8N350 | CBARP_HUMAN | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Homo | <M><Q><P><T><A><T><M><A><T><A><A><T><T><T><T><T><T><T><A><T><V><A><L><T><T><S><W><D><N><A><T><G><R><P><T><A><E><P><D><P><I><L><D><N><Y><V><L><L><V><V><V><M><S><L><F><V><G><G><T><L><V><V><L><S><G><V><L><L><L><C><K><R><C><W><D><V><H><Q><R><L><N><R><A><M><E><E><A><E><K><T><T><T><T><Y><L><D><N><G><T><H><P><A><Q><D><P><D><F... | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.<BOP> | Q8N350 |
O95221 | OR5F1_HUMAN | Olfactory receptor OR11-167 | Homo | <M><T><R><K><N><Y><T><S><L><T><E><F><V><L><L><G><L><A><D><T><L><E><L><Q><I><I><L><F><L><F><F><L><V><I><Y><T><L><T><V><L><G><N><L><G><M><I><L><L><I><R><I><D><S><Q><L><H><T><P><M><Y><F><F><L><A><N><L><S><F><V><D><V><C><N><S><T><T><I><T><P><K><M><L><A><D><L><L><S><E><K><K><T><I><S><F><A><G><C><F><L><Q><M><Y><F><F><I><S><L... | Odorant receptor.<BOP> | O95221 |
Q9Y2N7 | HIF3A_HUMAN | PAS domain-containing protein 7 | Homo | <M><A><L><G><L><Q><R><A><R><S><T><T><E><L><R><K><E><K><S><R><D><A><A><R><S><R><R><S><Q><E><T><E><V><L><Y><Q><L><A><H><T><L><P><F><A><R><G><V><S><A><H><L><D><K><A><S><I><M><R><L><T><I><S><Y><L><R><M><H><R><L><C><A><A><G><E><W><N><Q><V><G><A><G><G><E><P><L><D><A><C><Y><L><K><A><L><E><G><F><V><M><V><L><T><A><E><G><D><M><A... | Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.<BOP> | Q9Y2N7 |
P23258 | TBG1_HUMAN | Gamma-tubulin complex component 1 | Homo | <M><P><R><E><I><I><T><L><Q><L><G><Q><C><G><N><Q><I><G><F><E><F><W><K><Q><L><C><A><E><H><G><I><S><P><E><G><I><V><E><E><F><A><T><E><G><T><D><R><K><D><V><F><F><Y><Q><A><D><D><E><H><Y><I><P><R><A><V><L><L><D><L><E><P><R><V><I><H><S><I><L><N><S><P><Y><A><K><L><Y><N><P><E><N><I><Y><L><S><E><H><G><G><G><A><G><N><N><W><A><S><G... | Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.<BOP> | P23258 |
P83916 | CBX1_HUMAN | p25beta | Homo | <M><G><K><K><Q><N><K><K><K><V><E><E><V><L><E><E><E><E><E><E><Y><V><V><E><K><V><L><D><R><R><V><V><K><G><K><V><E><Y><L><L><K><W><K><G><F><S><D><E><D><N><T><W><E><P><E><E><N><L><D><C><P><D><L><I><A><E><F><L><Q><S><Q><K><T><A><H><E><T><D><K><S><E><G><G><K><R><K><A><D><S><D><S><E><D><K><G><E><E><S><K><P><K><K><K><K><E><E><S... | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.<BOP> | P83916 |
P20366 | TKN1_HUMAN | C-terminal-flanking peptide | Homo | <M><K><I><L><V><A><L><A><V><F><F><L><V><S><T><Q><L><F><A><E><E><I><G><A><N><D><D><L><N><Y><W><S><D><W><Y><D><S><D><Q><I><K><E><E><L><P><E><P><F><E><H><L><L><Q><R><I><A><R><R><P><K><P><Q><Q><F><F><G><L><M><G><K><R><D><A><D><S><S><I><E><K><Q><V><A><L><L><K><A><L><Y><G><H><G><Q><I><S><H><K><R><H><K><T><D><S><F><V><G><L><M... | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.<BOP> | P20366 |
P43121 | MUC18_HUMAN | S-endo 1 endothelial-associated antigen | Homo | <M><G><L><P><R><L><V><C><A><F><L><L><A><A><C><C><C><C><P><R><V><A><G><V><P><G><E><A><E><Q><P><A><P><E><L><V><E><V><E><V><G><S><T><A><L><L><K><C><G><L><S><Q><S><Q><G><N><L><S><H><V><D><W><F><S><V><H><K><E><K><R><T><L><I><F><R><V><R><Q><G><Q><G><Q><S><E><P><G><E><Y><E><Q><R><L><S><L><Q><D><R><G><A><T><L><A><L><T><Q><V><T... | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest... | P43121 |
P78563 | RED1_HUMAN | dsRNA adenosine deaminase | Homo | <M><D><I><E><D><E><E><N><M><S><S><S><S><T><D><V><K><E><N><R><N><L><D><N><V><S><P><K><D><G><S><T><P><G><P><G><E><G><S><Q><L><S><N><G><G><G><G><G><P><G><R><K><R><P><L><E><E><G><S><N><G><H><S><K><Y><R><L><K><K><R><R><K><T><P><G><P><V><L><P><K><N><A><L><M><Q><L><N><E><I><K><P><G><L><Q><Y><T><L><L><S><Q><T><G><P><V><H><A><P... | Has a higher catalytic activity than isoform 1.<BOP> | P78563 |
Q9NRF8 | PYRG2_HUMAN | UTP--ammonia ligase 2 | Homo | <M><K><Y><I><L><V><T><G><G><V><I><S><G><I><G><K><G><I><I><A><S><S><I><G><T><I><L><K><S><C><G><L><R><V><T><A><I><K><I><D><P><Y><I><N><I><D><A><G><T><F><S><P><Y><E><H><G><E><V><F><V><L><N><D><G><G><E><V><D><L><D><L><G><N><Y><E><R><F><L><D><I><N><L><Y><K><D><N><N><I><T><T><G><K><I><Y><Q><H><V><I><N><K><E><R><R><G><D><Y><L... | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<BOP> | Q9NRF8 |
P48382 | RFX5_HUMAN | Regulatory factor X 5 | Homo | <M><A><E><D><E><P><D><A><K><S><P><K><T><G><G><R><A><P><P><G><G><A><E><A><G><E><P><T><T><L><L><Q><R><L><R><G><T><I><S><K><A><V><Q><N><K><V><E><G><I><L><Q><D><V><Q><K><F><S><D><N><D><K><L><Y><L><Y><L><Q><L><P><S><G><P><T><T><G><D><K><S><S><E><P><S><T><L><S><N><E><E><Y><M><Y><A><Y><R><W><I><R><N><H><L><E><E><H><T><D><T><C... | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.<BOP> | P48382 |
P08670 | VIME_HUMAN | Vimentin | Homo | <M><S><T><R><S><V><S><S><S><S><Y><R><R><M><F><G><G><P><G><T><A><S><R><P><S><S><S><R><S><Y><V><T><T><S><T><R><T><Y><S><L><G><S><A><L><R><P><S><T><S><R><S><L><Y><A><S><S><P><G><G><V><Y><A><T><R><S><S><A><V><R><L><R><S><S><V><P><G><V><R><L><L><Q><D><S><V><D><F><S><L><A><D><A><I><N><T><E><F><K><N><T><R><T><N><E><K><V><E><L... | Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.<BOP> | P08670 |
P13805 | TNNT1_HUMAN | Slow skeletal muscle troponin T | Homo | <M><S><D><T><E><E><Q><E><Y><E><E><E><Q><P><E><E><E><A><A><E><E><E><E><E><A><P><E><E><P><E><P><V><A><E><P><E><E><E><R><P><K><P><S><R><P><V><V><P><P><L><I><P><P><K><I><P><E><G><E><R><V><D><F><D><D><I><H><R><K><R><M><E><K><D><L><L><E><L><Q><T><L><I><D><V><H><F><E><Q><R><K><K><E><E><E><E><L><V><A><L><K><E><R><I><E><R><R><R... | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP> | P13805 |
P82970 | HMGN5_HUMAN | Nucleosome-binding protein 1 | Homo | <M><P><K><R><K><A><A><G><Q><G><D><M><R><Q><E><P><K><R><R><S><A><R><L><S><A><M><L><V><P><V><T><P><E><V><K><P><K><R><T><S><S><S><R><K><M><K><T><K><S><D><M><M><E><E><N><I><D><T><S><A><Q><A><V><A><E><T><K><Q><E><A><V><V><E><E><D><Y><N><E><N><A><K><N><G><E><A><K><I><T><E><A><P><A><S><E><K><E><I><V><E><V><K><E><E><N><I><E><D... | Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.<BOP> | P82970 |
Q9NPY3 | C1QR1_HUMAN | Matrix-remodeling-associated protein 4 | Homo | <M><A><T><S><M><G><L><L><L><L><L><L><L><L><L><T><Q><P><G><A><G><T><G><A><D><T><E><A><V><V><C><V><G><T><A><C><Y><T><A><H><S><G><K><L><S><A><A><E><A><Q><N><H><C><N><Q><N><G><G><N><L><A><T><V><K><S><K><E><E><A><Q><H><V><Q><R><V><L><A><Q><L><L><R><R><E><A><A><L><T><A><R><M><S><K><F><W><I><G><L><Q><R><E><K><G><K><C><L><D><P... | Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.<BOP> | Q9NPY3 |
O15529 | GPR42_HUMAN | G-protein coupled receptor 42 | Homo | <M><D><T><G><P><D><Q><S><Y><F><S><G><N><H><W><F><V><F><S><V><Y><L><L><T><F><L><V><G><L><P><L><N><L><L><A><L><V><V><F><V><G><K><L><R><C><R><P><V><A><V><D><V><L><L><L><N><L><T><A><S><D><L><L><L><L><L><F><L><P><F><R><M><V><E><A><A><N><G><M><H><W><P><L><P><F><I><L><C><P><L><S><G><F><I><F><F><T><T><I><Y><L><T><A><L><F><L><A... | Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.<BOP> | O15529 |
P34995 | PE2R1_HUMAN | Prostanoid EP1 receptor | Homo | <M><S><P><C><G><P><L><N><L><S><L><A><G><E><A><T><T><C><A><A><P><W><V><P><N><T><S><A><V><P><P><S><G><A><S><P><A><L><P><I><F><S><M><T><L><G><A><V><S><N><L><L><A><L><A><L><L><A><Q><A><A><G><R><L><R><R><R><R><S><A><A><T><F><L><L><F><V><A><S><L><L><A><T><D><L><A><G><H><V><I><P><G><A><L><V><L><R><L><Y><T><A><G><R><A><P><A><G... | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.<BOP> | P34995 |
P08476 | INHBA_HUMAN | Erythroid differentiation protein | Homo | <M><P><L><L><W><L><R><G><F><L><L><A><S><C><W><I><I><V><R><S><S><P><T><P><G><S><E><G><H><S><A><A><P><D><C><P><S><C><A><L><A><A><L><P><K><D><V><P><N><S><Q><P><E><M><V><E><A><V><K><K><H><I><L><N><M><L><H><L><K><K><R><P><D><V><T><Q><P><V><P><K><A><A><L><L><N><A><I><R><K><L><H><V><G><K><V><G><E><N><G><Y><V><E><I><E><D><D><I... | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid diffe... | P08476 |
O43602 | DCX_HUMAN | Lissencephalin-X | Homo | <M><E><L><D><F><G><H><F><D><E><R><D><K><T><S><R><N><M><R><G><S><R><M><N><G><L><P><S><P><T><H><S><A><H><C><S><F><Y><R><T><R><T><L><Q><A><L><S><N><E><K><K><A><K><K><V><R><F><Y><R><N><G><D><R><Y><F><K><G><I><V><Y><A><V><S><S><D><R><F><R><S><F><D><A><L><L><A><D><L><T><R><S><L><S><D><N><I><N><L><P><Q><G><V><R><Y><I><Y><T><I... | Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal ... | O43602 |
Q76B58 | BRNP3_HUMAN | DBCCR1-like protein 1 | Homo | <M><I><W><R><S><R><A><G><A><E><L><F><S><L><M><A><L><W><E><W><I><A><L><S><L><H><C><W><V><L><A><V><A><A><V><S><D><Q><H><A><T><S><P><F><D><W><L><L><S><D><K><G><P><F><H><R><S><Q><E><Y><T><D><F><V><D><R><S><R><Q><G><F><S><T><R><Y><K><I><Y><R><E><F><G><R><W><K><V><N><N><L><A><V><E><R><R><N><F><L><G><S><P><L><P><L><A><P><E><F... | Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.<BOP> | Q76B58 |
P37287 | PIGA_HUMAN | Phosphatidylinositol-glycan biosynthesis class A protein | Homo | <M><A><C><R><G><G><A><G><N><G><H><R><A><S><A><T><L><S><R><V><S><P><G><S><L><Y><T><C><R><T><R><T><H><N><I><C><M><V><S><D><F><F><Y><P><N><M><G><G><V><E><S><H><I><Y><Q><L><S><Q><C><L><I><E><R><G><H><K><V><I><I><V><T><H><A><Y><G><N><R><K><G><I><R><Y><L><T><S><G><L><K><V><Y><Y><L><P><L><K><V><M><Y><N><Q><S><T><A><T><T><L><F... | Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP> | P37287 |
Q8NGC7 | O11H6_HUMAN | Olfactory receptor OR14-35 | Homo | <M><F><F><I><I><H><S><L><V><T><S><V><F><L><T><A><L><G><P><Q><N><R><T><M><H><F><V><T><E><F><V><L><L><G><F><H><G><Q><R><E><M><Q><S><C><F><F><S><F><I><L><V><L><Y><L><L><T><L><L><G><N><G><A><I><V><C><A><V><K><L><D><R><R><L><H><T><P><M><Y><I><L><L><G><N><F><A><F><L><E><I><W><Y><I><S><S><T><V><P><N><M><L><V><N><I><L><S><E><I... | Odorant receptor.<BOP> | Q8NGC7 |
Q9NRG1 | PRDC1_HUMAN | Phosphoribosyltransferase domain-containing protein 1 | Homo | <M><A><G><S><S><E><E><A><P><D><Y><G><R><G><V><V><I><M><D><D><W><P><G><Y><D><L><N><L><F><T><Y><P><Q><H><Y><Y><G><D><L><E><Y><V><L><I><P><H><G><I><I><V><D><R><I><E><R><L><A><K><D><I><M><K><D><I><G><Y><S><D><I><M><V><L><C><V><L><K><G><G><Y><K><F><C><A><D><L><V><E><H><L><K><N><I><S><R><N><S><D><R><F><V><S><M><K><V><D><F><I... | Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.<BOP> | Q9NRG1 |
P46777 | RL5_HUMAN | Large ribosomal subunit protein uL18 | Homo | <M><G><F><V><K><V><V><K><N><K><A><Y><F><K><R><Y><Q><V><K><F><R><R><R><R><E><G><K><T><D><Y><Y><A><R><K><R><L><V><I><Q><D><K><N><K><Y><N><T><P><K><Y><R><M><I><V><R><V><T><N><R><D><I><I><C><Q><I><A><Y><A><R><I><E><G><D><M><I><V><C><A><A><Y><A><H><E><L><P><K><Y><G><V><K><V><G><L><T><N><Y><A><A><A><Y><C><T><G><L><L><L><A><R... | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosom... | P46777 |
P13640 | MT1G_HUMAN | Metallothionein-IG | Homo | <M><D><P><N><C><S><C><A><A><A><G><V><S><C><T><C><A><S><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><V><G><C><A><K><C><A><Q><G><C><I><C><K><G><A><S><E><K><C><S><C><C><A> | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP> | P13640 |
Q9UJW9 | SRTD3_HUMAN | Replication protein-binding trans-activator | Homo | <M><V><G><G><L><K><R><K><H><S><D><L><E><E><E><E><E><R><W><E><W><S><P><A><G><L><Q><S><Y><Q><Q><A><L><L><R><I><S><L><D><K><V><Q><R><S><L><G><P><R><A><P><S><L><R><R><H><V><L><I><H><N><T><L><Q><Q><L><Q><A><A><L><R><L><A><P><A><P><A><L><P><P><E><P><L><F><L><G><E><E><D><F><S><L><S><A><T><I><G><S><I><L><R><E><L><D><T><S><M><D... | Strong transcriptional coactivator.<BOP> | Q9UJW9 |
Q02252 | MMSA_HUMAN | Aldehyde dehydrogenase family 6 member A1 | Homo | <M><A><A><L><L><A><A><A><A><V><R><A><R><I><L><Q><V><S><S><K><V><K><S><S><P><T><W><Y><S><A><S><S><F><S><S><S><V><P><T><V><K><L><F><I><G><G><K><F><V><E><S><K><S><D><K><W><I><D><I><H><N><P><A><T><N><E><V><I><G><R><V><P><Q><A><T><K><A><E><M><D><A><A><I><A><S><C><K><R><A><F><P><A><W><A><D><T><S><V><L><S><R><Q><Q><V><L><L><R... | Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.<BOP> | Q02252 |
Q9BUU2 | MET22_HUMAN | Methyltransferase-like protein 22 | Homo | <M><V><Q><L><A><P><A><A><A><M><D><E><V><T><F><R><S><D><T><V><L><S><D><V><H><L><Y><T><P><N><H><R><H><L><M><V><R><L><N><S><V><G><Q><P><V><F><L><S><Q><F><K><L><L><W><S><Q><D><S><W><T><D><S><G><A><K><G><G><S><H><R><D><V><H><T><K><E><P><P><S><A><E><T><G><S><T><G><S><P><P><G><S><G><H><G><N><E><G><F><S><L><Q><A><G><T><D><T><T... | Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro).<BOP> | Q9BUU2 |
Q05D32 | CTSL2_HUMAN | CTD small phosphatase-like protein 2 | Homo | <M><R><L><R><T><R><K><A><S><Q><Q><S><N><Q><I><Q><T><Q><R><T><A><R><A><K><R><K><Y><S><E><V><D><D><S><L><P><S><G><G><E><K><P><S><K><N><E><T><G><L><L><S><S><I><K><K><F><I><K><G><S><T><P><K><E><E><R><E><N><P><S><K><R><S><R><I><E><R><D><I><D><N><N><L><I><T><S><T><P><R><A><G><E><K><P><N><K><Q><I><S><R><V><R><R><K><S><Q><V><N... | Probable phosphatase.<BOP> | Q05D32 |
P47736 | RPGP1_HUMAN | Rap1 GTPase-activating protein 1 | Homo | <M><I><E><K><M><Q><G><S><R><M><D><E><Q><R><C><S><F><P><P><P><L><K><T><E><E><D><Y><I><P><Y><P><S><V><H><E><V><L><G><R><E><G><P><F><P><L><I><L><L><P><Q><F><G><G><Y><W><I><E><G><T><N><H><E><I><T><S><I><P><E><T><E><P><L><Q><S><P><T><T><K><V><K><L><E><C><N><P><T><A><R><I><Y><R><K><H><F><L><G><K><E><H><F><N><Y><Y><S><L><D><A... | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.<BOP> | P47736 |
Q8IZE3 | PACE1_HUMAN | SCY1-like protein 3 | Homo | <M><G><S><E><N><S><A><L><K><S><Y><T><L><R><E><P><P><F><T><L><P><S><G><L><A><V><Y><P><A><V><L><Q><D><G><K><F><A><S><V><F><V><Y><K><R><E><N><E><D><K><V><N><K><A><A><K><H><L><K><T><L><R><H><P><C><L><L><R><F><L><S><C><T><V><E><A><D><G><I><H><L><V><T><E><R><V><Q><P><L><E><V><A><L><E><T><L><S><S><A><E><V><C><A><G><I><Y><D><I... | May play a role in regulating cell adhesion/migration complexes in migrating cells.<BOP> | Q8IZE3 |
Q8NGN6 | O10G7_HUMAN | Olfactory receptor OR11-283 | Homo | <M><S><N><A><T><L><L><T><A><F><I><L><T><G><L><P><H><A><P><G><L><D><A><P><L><F><G><I><F><L><V><V><Y><V><L><T><V><L><G><N><L><L><I><L><L><V><I><R><V><D><S><H><L><H><T><P><M><Y><Y><F><L><T><N><L><S><F><I><D><M><W><F><S><T><V><T><V><P><K><M><L><M><T><L><V><S><P><S><G><R><T><I><S><F><H><S><C><V><A><Q><L><Y><F><F><H><F><L><G... | Odorant receptor.<BOP> | Q8NGN6 |
Q92466 | DDB2_HUMAN | UV-damaged DNA-binding protein 2 | Homo | <M><A><P><K><K><R><P><E><T><Q><K><T><S><E><I><V><L><R><P><R><N><K><R><S><R><S><P><L><E><L><E><P><E><A><K><K><L><C><A><K><G><S><G><P><S><R><R><C><D><S><D><C><L><W><V><G><L><A><G><P><Q><I><L><P><P><C><R><S><I><V><R><T><L><H><Q><H><K><L><G><R><A><S><W><P><S><V><Q><Q><G><L><Q><Q><S><F><L><H><T><L><D><S><Y><R><I><L><Q><K><A... | Inhibits UV-damaged DNA repair.<BOP> | Q92466 |
P11487 | FGF3_HUMAN | Proto-oncogene Int-2 | Homo | <M><G><L><I><W><L><L><L><L><S><L><L><E><P><G><W><P><A><A><G><P><G><A><R><L><R><R><D><A><G><G><R><G><G><V><Y><E><H><L><G><G><A><P><R><R><R><K><L><Y><C><A><T><K><Y><H><L><Q><L><H><P><S><G><R><V><N><G><S><L><E><N><S><A><Y><S><I><L><E><I><T><A><V><E><V><G><I><V><A><I><R><G><L><F><S><G><R><Y><L><A><M><N><K><R><G><R><L><Y><A... | Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.<BOP> | P11487 |
P19087 | GNAT2_HUMAN | Transducin alpha-2 chain | Homo | <M><G><S><G><A><S><A><E><D><K><E><L><A><K><R><S><K><E><L><E><K><K><L><Q><E><D><A><D><K><E><A><K><T><V><K><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><K><I><I><H><Q><D><G><Y><S><P><E><E><C><L><E><F><K><A><I><I><Y><G><N><V><L><Q><S><I><L><A><I><I><R><A><M><T><T><L><G><I><D><Y><A><E><P><S><C><A><D><D><G><R><Q><L... | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.<BOP> | P19087 |
P36544 | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 | Homo | <M><R><C><S><P><G><G><V><W><L><A><L><A><A><S><L><L><H><V><S><L><Q><G><E><F><Q><R><K><L><Y><K><E><L><V><K><N><Y><N><P><L><E><R><P><V><A><N><D><S><Q><P><L><T><V><Y><F><S><L><S><L><L><Q><I><M><D><V><D><E><K><N><Q><V><L><T><T><N><I><W><L><Q><M><S><W><T><D><H><Y><L><Q><W><N><V><S><E><Y><P><G><V><K><T><V><R><F><P><D><G><Q><I... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.<BOP> | P36544 |
P14207 | FOLR2_HUMAN | Placental folate-binding protein | Homo | <M><V><W><K><W><M><P><L><L><L><L><L><V><C><V><A><T><M><C><S><A><Q><D><R><T><D><L><L><N><V><C><M><D><A><K><H><H><K><T><K><P><G><P><E><D><K><L><H><D><Q><C><S><P><W><K><K><N><A><C><C><T><A><S><T><S><Q><E><L><H><K><D><T><S><R><L><Y><N><F><N><W><D><H><C><G><K><M><E><P><A><C><K><R><H><F><I><Q><D><T><C><L><Y><E><C><S><P><N><L... | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly re... | P14207 |
Q9GZN4 | BSSP4_HUMAN | Tryptase epsilon | Homo | <M><V><V><S><G><A><P><P><A><L><G><G><G><C><L><G><T><F><T><S><L><L><L><L><A><S><T><A><I><L><N><A><A><R><I><P><V><P><P><A><C><G><K><P><Q><Q><L><N><R><V><V><G><G><E><D><S><T><D><S><E><W><P><W><I><V><S><I><Q><K><N><G><T><H><H><C><A><G><S><L><L><T><S><R><W><V><I><T><A><A><H><C><F><K><D><N><L><N><K><P><Y><L><F><S><V><L><L><G... | Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.<BOP> | Q9GZN4 |
Q8N138 | ORML3_HUMAN | ORM1-like protein 3 | Homo | <M><N><V><G><T><A><H><S><E><V><N><P><N><T><R><V><M><N><S><R><G><I><W><L><S><Y><V><L><A><I><G><L><L><H><I><V><L><L><S><I><P><F><V><S><V><P><V><V><W><T><L><T><N><L><I><H><N><M><G><M><Y><I><F><L><H><T><V><K><G><T><P><F><E><T><P><D><Q><G><K><A><R><L><L><T><H><W><E><Q><M><D><Y><G><V><Q><F><T><A><S><R><K><F><L><T><I><T><P><I... | Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.<BOP> | Q8N138 |
O75475 | PSIP1_HUMAN | Transcriptional coactivator p75/p52 | Homo | <M><T><R><D><F><K><P><G><D><L><I><F><A><K><M><K><G><Y><P><H><W><P><A><R><V><D><E><V><P><D><G><A><V><K><P><P><T><N><K><L><P><I><F><F><F><G><T><H><E><T><A><F><L><G><P><K><D><I><F><P><Y><S><E><N><K><E><K><Y><G><K><P><N><K><R><K><G><F><N><E><G><L><W><E><I><D><N><N><P><K><V><K><F><S><S><Q><Q><A><A><T><K><Q><S><N><A><S><S><D... | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced ... | O75475 |
O75452 | RDH16_HUMAN | Sterol/retinol dehydrogenase | Homo | <M><W><L><Y><L><A><V><F><V><G><L><Y><Y><L><L><H><W><Y><R><E><R><Q><V><L><S><H><L><R><D><K><Y><V><F><I><T><G><C><D><S><G><F><G><K><L><L><A><R><Q><L><D><A><R><G><L><R><V><L><A><A><C><L><T><E><K><G><A><E><Q><L><R><G><Q><T><S><D><R><L><E><T><V><T><L><D><V><T><K><T><E><S><V><A><A><A><A><Q><W><V><K><E><C><V><R><D><K><G><L><W... | Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes . Has higher activity towards CRBP-bound retinol than with free retinol . Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestos... | O75452 |
Q86Y07 | VRK2_HUMAN | Vaccinia-related kinase 2 | Homo | <M><P><P><K><R><N><E><K><Y><K><L><P><I><P><F><P><E><G><K><V><L><D><D><M><E><G><N><Q><W><V><L><G><K><K><I><G><S><G><G><F><G><L><I><Y><L><A><F><P><T><N><K><P><E><K><D><A><R><H><V><V><K><V><E><Y><Q><E><N><G><P><L><F><S><E><L><K><F><Y><Q><R><V><A><K><K><D><C><I><K><K><W><I><E><R><K><Q><L><D><Y><L><G><I><P><L><F><Y><G><S><G... | Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.<BOP> | Q86Y07 |
P43627 | KI2L2_HUMAN | p58 natural killer cell receptor clone CL-43 | Homo | <M><S><L><M><V><V><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><P><H><E><G><V><H><R><K><P><S><L><L><A><H><P><G><R><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><R><F><E><H><F><L><L><H><R><E><G><K><F><K><D><T><L><H><L><I><G><E><H><H><D><G><V><S><K><A><N><F><S><I><G><P><M><M><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><T><H><S... | Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.<BOP> | P43627 |
Q9P2E8 | MARH4_HUMAN | RING-type E3 ubiquitin transferase MARCHF4 | Homo | <M><L><M><P><L><C><G><L><L><W><W><W><W><C><C><C><S><G><W><Y><C><Y><G><L><C><A><P><A><P><Q><M><L><R><H><Q><G><L><L><K><C><R><C><R><M><L><F><N><D><L><K><V><F><L><L><R><R><P><P><Q><A><P><L><P><M><H><G><D><P><Q><P><P><G><L><A><A><N><N><T><L><P><A><L><G><A><G><G><W><A><G><W><R><G><P><R><E><V><V><G><R><E><P><P><P><V><P><P><P... | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to ... | Q9P2E8 |
Q8IUH8 | SPP2C_HUMAN | Intramembrane protease 5 | Homo | <M><A><C><L><G><F><L><L><P><V><G><F><L><L><L><I><S><T><V><A><G><G><K><Y><G><V><A><H><V><V><S><E><N><W><S><K><D><Y><C><I><L><F><S><S><D><Y><I><T><L><P><R><D><L><H><H><A><P><L><L><P><L><Y><D><G><T><K><A><P><W><C><P><G><E><D><S><P><H><Q><A><Q><L><R><S><P><S><Q><R><P><L><R><Q><T><T><A><M><V><M><R><G><N><C><S><F><H><T><K><G... | Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.<BOP> | Q8IUH8 |
Q9NW81 | DMAC2_HUMAN | ATP synthase subunit s-like protein | Homo | <M><A><A><P><W><A><S><L><R><L><V><A><P><M><W><N><G><R><I><R><G><I><H><R><L><G><A><A><V><A><P><E><G><N><Q><K><K><K><R><T><I><L><Q><F><L><T><N><Y><F><Y><D><V><E><A><L><R><D><Y><L><L><Q><R><E><M><Y><K><V><H><E><K><N><R><S><Y><T><W><L><E><K><Q><H><G><P><Y><G><A><G><A><F><F><I><L><K><Q><G><G><A><V><K><F><R><D><K><E><W><I><R... | Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.<BOP> | Q9NW81 |
Q8NI60 | COQ8A_HUMAN | aarF domain-containing protein kinase 3 | Homo | <M><A><A><I><L><G><D><T><I><M><V><A><K><G><L><V><K><L><T><Q><A><A><V><E><T><H><L><Q><H><L><G><I><G><G><E><L><I><M><A><A><R><A><L><Q><S><T><A><V><E><Q><I><G><M><F><L><G><K><V><Q><G><Q><D><K><H><E><E><Y><F><A><E><N><F><G><G><P><E><G><E><F><H><F><S><V><P><H><A><A><G><A><S><T><D><F><S><S><A><S><A><P><D><Q><S><A><P><P><S><L... | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration . Its substrate specificity is unclear: does not show any protein kinase activity . Probably acts as a small molecule kinase, possibly a lipid kinase that p... | Q8NI60 |
Q99594 | TEAD3_HUMAN | TEA domain family member 3 | Homo | <M><A><S><N><S><W><N><A><S><S><S><P><G><E><A><R><E><D><G><P><E><G><L><D><K><G><L><D><N><D><A><E><G><V><W><S><P><D><I><E><Q><S><F><Q><E><A><L><A><I><Y><P><P><C><G><R><R><K><I><I><L><S><D><E><G><K><M><Y><G><R><N><E><L><I><A><R><Y><I><K><L><R><T><G><K><T><R><T><R><K><Q><V><S><S><H><I><Q><V><L><A><R><K><K><V><R><E><Y><Q><V... | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosph... | Q99594 |
Q5SVS4 | KMCP1_HUMAN | Solute carrier family 25 member 30 | Homo | <M><S><A><L><N><W><K><P><F><V><Y><G><G><L><A><S><I><T><A><E><C><G><T><F><P><I><D><L><T><K><T><R><L><Q><I><Q><G><Q><T><N><D><A><K><F><K><E><I><R><Y><R><G><M><L><H><A><L><V><R><I><G><R><E><E><G><L><K><A><L><Y><S><G><I><A><P><A><M><L><R><Q><A><S><Y><G><T><I><K><I><G><T><Y><Q><S><L><K><R><L><F><I><E><R><P><E><D><E><T><L><P... | Probable transporter.<BOP> | Q5SVS4 |
Q15796 | SMAD2_HUMAN | SMAD family member 2 | Homo | <M><S><S><I><L><P><F><T><P><P><V><V><K><R><L><L><G><W><K><K><S><A><G><G><S><G><G><A><G><G><G><E><Q><N><G><Q><E><E><K><W><C><E><K><A><V><K><S><L><V><K><K><L><K><K><T><G><R><L><D><E><L><E><K><A><I><T><T><Q><N><C><N><T><K><C><V><T><I><P><S><T><C><S><E><I><W><G><L><S><T><P><N><T><I><D><Q><W><D><T><T><G><L><Y><S><F><S><E><Q... | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4... | Q15796 |
O00187 | MASP2_HUMAN | Mannan-binding lectin serine protease 2 B chain | Homo | <M><R><L><L><T><L><L><G><L><L><C><G><S><V><A><T><P><L><G><P><K><W><P><E><P><V><F><G><R><L><A><S><P><G><F><P><G><E><Y><A><N><D><Q><E><R><R><W><T><L><T><A><P><P><G><Y><R><L><R><L><Y><F><T><H><F><D><L><E><L><S><H><L><C><E><Y><D><F><V><K><L><S><S><G><A><K><V><L><A><T><L><C><G><Q><E><S><T><D><T><E><R><A><P><G><K><D><T><F><Y... | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<BOP> | O00187 |
O95251 | KAT7_HUMAN | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 | Homo | <M><P><R><R><K><R><N><A><G><S><S><S><D><G><T><E><D><S><D><F><S><T><D><L><E><H><T><D><S><S><E><S><D><G><T><S><R><R><S><A><R><V><T><R><S><S><A><R><L><S><Q><S><S><Q><D><S><S><P><V><R><N><L><Q><S><F><G><T><E><E><P><A><Y><S><T><R><R><V><T><R><S><Q><Q><Q><P><T><P><V><T><P><K><K><Y><P><L><R><Q><T><R><S><S><G><S><E><T><E><Q><V... | Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) . Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the f... | O95251 |
Q9NRY6 | PLS3_HUMAN | Ca(2+)-dependent phospholipid scramblase 3 | Homo | <M><A><G><Y><L><P><P><K><G><Y><A><P><S><P><P><P><P><Y><P><V><T><P><G><Y><P><E><P><A><L><H><P><G><P><G><Q><A><P><V><P><A><Q><V><P><A><P><A><P><G><F><A><L><F><P><S><P><G><P><V><A><L><G><S><A><A><P><F><L><P><L><P><G><V><P><S><G><L><E><F><L><V><Q><I><D><Q><I><L><I><H><Q><K><A><E><R><V><E><T><F><L><G><W><E><T><C><N><R><Y><E... | Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria . Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response . Mediates the t... | Q9NRY6 |
O15296 | LX15B_HUMAN | Linoleate 13-lipoxygenase 15-LOb | Homo | <M><A><E><F><R><V><R><V><S><T><G><E><A><F><G><A><G><T><W><D><K><V><S><V><S><I><V><G><T><R><G><E><S><P><P><L><P><L><D><N><L><G><K><E><F><T><A><G><A><E><E><D><F><Q><V><T><L><P><E><D><V><G><R><V><L><L><L><R><V><H><K><A><P><P><V><L><P><L><L><G><P><L><A><P><D><A><W><F><C><R><W><F><Q><L><T><P><P><R><G><G><H><L><L><F><P><C><Y... | Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.<BOP> | O15296 |
O75955 | FLOT1_HUMAN | Flotillin-1 | Homo | <M><F><F><T><C><G><P><N><E><A><M><V><V><S><G><F><C><R><S><P><P><V><M><V><A><G><G><R><V><F><V><L><P><C><I><Q><Q><I><Q><R><I><S><L><N><T><L><T><L><N><V><K><S><E><K><V><Y><T><R><H><G><V><P><I><S><V><T><G><I><A><Q><V><K><I><Q><G><Q><N><K><E><M><L><A><A><A><C><Q><M><F><L><G><K><T><E><A><E><I><A><H><I><A><L><E><T><L><E><G><H... | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.<BOP> | O75955 |
Q8TF42 | UBS3B_HUMAN | Tyrosine-protein phosphatase STS1/TULA2 | Homo | <M><A><Q><Y><G><H><P><S><P><L><G><M><A><A><R><E><E><L><Y><S><K><V><T><P><R><R><N><R><Q><Q><R><P><G><T><I><K><H><G><S><A><L><D><V><L><L><S><M><G><F><P><R><A><R><A><Q><K><A><L><A><S><T><G><G><R><S><V><Q><A><A><C><D><W><L><F><S><H><V><G><D><P><F><L><D><D><P><L><P><R><E><Y><V><L><Y><L><R><P><T><G><P><L><A><Q><K><L><S><D><F... | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulate... | Q8TF42 |
Q9NPG8 | ZDHC4_HUMAN | Zinc finger protein 374 | Homo | <M><D><F><L><V><L><F><L><F><Y><L><A><S><V><L><M><G><L><V><L><I><C><V><C><S><K><T><H><S><L><K><G><L><A><R><G><G><A><Q><I><F><S><C><I><I><P><E><C><L><Q><R><A><V><H><G><L><L><H><Y><L><F><H><T><R><N><H><T><F><I><V><L><H><L><V><L><Q><G><M><V><Y><T><E><Y><T><W><E><V><F><G><Y><C><Q><E><L><E><L><S><L><H><Y><L><L><L><P><Y><L><L... | Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2.<BOP> | Q9NPG8 |
Q12899 | TRI26_HUMAN | Zinc finger protein 173 | Homo | <M><A><T><S><A><P><L><R><S><L><E><E><E><V><T><C><S><I><C><L><D><Y><L><R><D><P><V><T><I><D><C><G><H><V><F><C><R><S><C><T><T><D><V><R><P><I><S><G><S><R><P><V><C><P><L><C><K><K><P><F><K><K><E><N><I><R><P><V><W><Q><L><A><S><L><V><E><N><I><E><R><L><K><V><D><K><G><R><Q><P><G><E><V><T><R><E><Q><Q><D><A><K><L><C><E><R><H><R><E... | E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the... | Q12899 |
Q8TCQ1 | MARH1_HUMAN | RING-type E3 ubiquitin transferase MARCHF1 | Homo | <M><L><G><W><C><E><A><I><A><R><N><P><H><R><I><P><N><N><T><R><T><P><E><I><S><G><D><L><A><D><A><S><Q><T><S><T><L><N><E><K><S><P><G><R><S><A><S><R><S><S><N><I><S><K><A><S><S><P><T><T><G><T><A><P><R><S><Q><S><R><L><S><V><C><P><S><T><Q><D><I><C><R><I><C><H><C><E><G><D><E><E><S><P><L><I><T><P><C><R><C><T><G><T><L><R><F><V><H... | E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-reg... | Q8TCQ1 |
P33778 | H2B1B_HUMAN | Histone H2B.f | Homo | <M><P><E><P><S><K><S><A><P><A><P><K><K><G><S><K><K><A><I><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><I><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L... | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated v... | P33778 |
Q8IVH4 | MMAA_HUMAN | Methylmalonic aciduria type A protein, mitochondrial | Homo | <M><P><M><L><L><P><H><P><H><Q><H><F><L><K><G><L><L><R><A><P><F><R><C><Y><H><F><I><F><H><S><S><T><H><L><G><S><G><I><P><C><A><Q><P><F><N><S><L><G><L><H><C><T><K><W><M><L><L><S><D><G><L><K><R><K><L><C><V><Q><T><T><L><K><D><H><T><E><G><L><S><D><K><E><Q><R><F><V><D><K><L><Y><T><G><L><I><Q><G><Q><R><A><C><L><A><E><A><I><T><L... | GTPase, binds and hydrolyzes GTP . Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis . Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutas... | Q8IVH4 |
Q9HAF1 | EAF6_HUMAN | Sarcoma antigen NY-SAR-91 | Homo | <M><A><M><H><N><K><A><A><P><P><Q><I><P><D><T><R><R><E><L><A><E><L><V><K><R><K><Q><E><L><A><E><T><L><A><N><L><E><R><Q><I><Y><A><F><E><G><S><Y><L><E><D><T><Q><M><Y><G><N><I><I><R><G><W><D><R><Y><L><T><N><Q><K><N><S><N><S><K><N><D><R><R><N><R><K><F><K><E><A><E><R><L><F><S><K><S><S><V><T><S><A><A><A><V><S><A><L><A><G><V><Q... | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A . This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which... | Q9HAF1 |
A0A087WT01 | TVA27_HUMAN | T cell receptor alpha variable 27 | Homo | <M><V><L><K><F><S><V><S><I><L><W><I><Q><L><A><W><V><S><T><Q><L><L><E><Q><S><P><Q><F><L><S><I><Q><E><G><E><N><L><T><V><Y><C><N><S><S><S><V><F><S><S><L><Q><W><Y><R><Q><E><P><G><E><G><P><V><L><L><V><T><V><V><T><G><G><E><V><K><K><L><K><R><L><T><F><Q><F><G><D><A><R><K><D><S><S><L><H><I><T><A><A><Q><T><G><D><T><G><L><Y><L><C... | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (... | A0A087WT01 |
P0DPD5 | ZN723_HUMAN | Zinc finger protein 723 | Homo | <M><G><P><L><T><F><T><D><V><A><I><K><F><S><L><E><E><W><Q><F><L><D><T><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><F><L><G><V><G><V><S><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><M><K><R><H><K><M><V><A><K><P><P><V><V><C><S><H><F><A><Q><D><L><W><P><E><Q><G><I><K><D><S><F><Q><K><V><I><L><R><S><Y><G><K><Y><G... | May be involved in transcriptional regulation.<BOP> | P0DPD5 |
Q07108 | CD69_HUMAN | MLR-3 | Homo | <M><S><S><E><N><C><F><V><A><E><N><S><S><L><H><P><E><S><G><Q><E><N><D><A><T><S><P><H><F><S><T><R><H><E><G><S><F><Q><V><P><V><L><C><A><V><M><N><V><V><F><I><T><I><L><I><I><A><L><I><A><L><S><V><G><Q><Y><N><C><P><G><Q><Y><T><F><S><M><P><S><D><S><H><V><S><S><C><S><E><D><W><V><G><Y><Q><R><K><C><Y><F><I><S><T><V><K><R><S><W><T... | Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.<BOP> | Q07108 |
A0A0B4J244 | TVA3_HUMAN | T cell receptor alpha variable 3 | Homo | <M><A><S><A><P><I><S><M><L><A><M><L><F><T><L><S><G><L><R><A><Q><S><V><A><Q><P><E><D><Q><V><N><V><A><E><G><N><P><L><T><V><K><C><T><Y><S><V><S><G><N><P><Y><L><F><W><Y><V><Q><Y><P><N><R><G><L><Q><F><L><L><K><Y><I><T><G><D><N><L><V><K><G><S><Y><G><F><E><A><E><F><N><K><S><Q><T><S><F><H><L><K><K><P><S><A><L><V><S><D><S><A><L... | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (... | A0A0B4J244 |
O75596 | CLC3A_HUMAN | Cartilage-derived C-type lectin | Homo | <M><A><K><N><G><L><V><I><C><I><L><V><I><T><L><L><L><D><Q><T><T><S><H><T><S><R><L><K><A><R><K><H><S><K><R><R><V><R><D><K><D><G><D><L><K><T><Q><I><E><K><L><W><T><E><V><N><A><L><K><E><I><Q><A><L><Q><T><V><C><L><R><G><T><K><V><H><K><K><C><Y><L><A><S><E><G><L><K><H><F><H><E><A><N><E><D><C><I><S><K><G><G><I><L><V><I><P><R><N... | Promotes cell adhesion to laminin-332 and fibronectin.<BOP> | O75596 |
Q9NZD4 | AHSP_HUMAN | Erythroid-associated factor | Homo | <M><A><L><L><K><A><N><K><D><L><I><S><A><G><L><K><E><F><S><V><L><L><N><Q><Q><V><F><N><D><P><L><V><S><E><E><D><M><V><T><V><V><E><D><W><M><N><F><Y><I><N><Y><Y><R><Q><Q><V><T><G><E><P><Q><E><R><D><K><A><L><Q><E><L><R><Q><E><L><N><T><L><A><N><P><F><L><A><K><Y><R><D><F><L><K><S><H><E><L><P><S><H><P><P><P><S><S> | Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<BOP> | Q9NZD4 |
Q6MZQ0 | PRR5L_HUMAN | Protein observed with Rictor-2 | Homo | <M><T><R><G><F><A><P><I><L><P><V><E><F><H><K><M><G><S><F><R><R><P><R><P><R><F><M><S><S><P><V><L><S><D><L><P><R><F><Q><A><A><R><Q><A><L><Q><L><S><S><S><S><A><W><N><S><V><Q><T><A><V><I><N><V><F><K><G><G><G><L><Q><S><N><E><L><Y><A><L><N><E><N><I><R><R><L><L><K><S><E><L><G><S><F><I><T><D><Y><F><Q><N><Q><L><L><A><K><G><L><F... | Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton . Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration . Plays a role in... | Q6MZQ0 |
P01920 | DQB1_HUMAN | MHC class II antigen DQB1 | Homo | <M><S><W><K><K><A><L><R><I><P><G><G><L><R><A><A><T><V><T><L><M><L><A><M><L><S><T><P><V><A><E><G><R><D><S><P><E><D><F><V><Y><Q><F><K><A><M><C><Y><F><T><N><G><T><E><R><V><R><Y><V><T><R><Y><I><Y><N><R><E><E><Y><A><R><F><D><S><D><V><E><V><Y><R><A><V><T><P><L><G><P><P><D><A><E><Y><W><N><S><Q><K><E><V><L><E><R><T><R><A><E><L... | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by deg... | P01920 |
P49662 | CASP4_HUMAN | Caspase-4 subunit p20 | Homo | <M><A><E><G><N><H><R><K><K><P><L><K><V><L><E><S><L><G><K><D><F><L><T><G><V><L><D><N><L><V><E><Q><N><V><L><N><W><K><E><E><E><K><K><K><Y><Y><D><A><K><T><E><D><K><V><R><V><M><A><D><S><M><Q><E><K><Q><R><M><A><G><Q><M><L><L><Q><T><F><F><N><I><D><Q><I><S><P><N><K><K><A><H><P><N><M><E><A><G><P><P><E><S><G><E><S><T><D><A><L><K... | (Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts.<BOP> | P49662 |
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