accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q96D59
RN183_HUMAN
E3 ubiquitin-protein ligase RNF183
Homo
<M><A><E><Q><Q><G><R><E><L><E><A><E><C><P><V><C><W><N><P><F><N><N><T><F><H><T><P><K><M><L><D><C><C><H><S><F><C><V><E><C><L><A><H><L><S><L><V><T><P><A><R><R><R><L><L><C><P><L><C><R><Q><P><T><V><L><A><S><G><Q><P><V><T><D><L><P><T><D><T><A><M><L><A><L><L><R><L><E><P><H><H><V><I><L><E><G><H><Q><L><C><L><K><D><Q><P><K><S><R><Y><F><L><R><Q><P><Q><V><Y><T><L><D><L><G><P><Q><P><G><G><Q><T><G><P><P><P><D><T><A><S><A><T><V><S><T><P><I><L><I><P><S><H><H><S><L><R><E><C><F><R><N><P><Q><F><R><I><F><A><Y><L><M><A><V><I><L><S><V><T><L><L><L><I><F><S><I><F><W><T><K><Q><F><L><W><G><V><G>
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 . May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling .<BOP>
Q96D59
Q9NXG2
THUM1_HUMAN
THUMP domain-containing protein 1
Homo
<M><A><A><P><A><Q><Q><T><T><Q><P><G><G><G><K><R><K><G><K><A><Q><Y><V><L><A><K><R><A><R><R><C><D><A><G><G><P><R><Q><L><E><P><G><L><Q><G><I><L><I><T><C><N><M><N><E><R><K><C><V><E><E><A><Y><S><L><L><N><E><Y><G><D><D><M><Y><G><P><E><K><F><T><D><K><D><Q><Q><P><S><G><S><E><G><E><D><D><D><A><E><A><A><L><K><K><E><V><G><D><I><K><A><S><T><E><M><R><L><R><R><F><Q><S><V><E><S><G><A><N><N><V><V><F><I><R><T><L><G><I><E><P><E><K><L><V><H><H><I><L><Q><D><M><Y><K><T><K><K><K><K><T><R><V><I><L><R><M><L><P><I><S><G><T><C><K><A><F><L><E><D><M><K><K><Y><A><E><T><F><L><E><P><W><F><K><A><P><N><K><G><T><F><Q><I><V><Y><K><S><R><N><N><S><H><V><N><R><E><E><V><I><R><E><L><A><G><I><V><C><T><L><N><S><E><N><K><V><D><L><T><N><P><Q><Y><T><V><V><V><E><I><I><K><A><V><C><C><L><S><V><V><K><D><Y><M><L><F><R><K><Y><N><L><Q><E><V><V><K><S><P><K><D><P><S><Q><L><N><S><K><Q><G><N><G><K><E><A><K><L><E><S><A><D><K><S><D><Q><N><N><T><A><E><G><K><N><N><Q><Q><V><P><E><N><T><E><E><L><G><Q><T><K><P><T><S><N><P><Q><V><V><N><E><G><G><A><K><P><E><L><A><S><Q><A><T><E><G><S><K><S><N><E><N><D><F><S>
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation .<BOP>
Q9NXG2
Q8TDU9
RL3R2_HUMAN
Relaxin family peptide receptor 4
Homo
<M><P><T><L><N><T><S><A><S><P><P><T><F><F><W><A><N><A><S><G><G><S><V><L><S><A><D><D><A><P><M><P><V><K><F><L><A><L><R><L><M><V><A><L><A><Y><G><L><V><G><A><I><G><L><L><G><N><L><A><V><L><W><V><L><S><N><C><A><R><R><A><P><G><P><P><S><D><T><F><V><F><N><L><A><L><A><D><L><G><L><A><L><T><L><P><F><W><A><A><E><S><A><L><D><F><H><W><P><F><G><G><A><L><C><K><M><V><L><T><A><T><V><L><N><V><Y><A><S><I><F><L><I><T><A><L><S><V><A><R><Y><W><V><V><A><M><A><A><G><P><G><T><H><L><S><L><F><W><A><R><I><A><T><L><A><V><W><A><A><A><A><L><V><T><V><P><T><A><V><F><G><V><E><G><E><V><C><G><V><R><L><C><L><L><R><F><P><S><R><Y><W><L><G><A><Y><Q><L><Q><R><V><V><L><A><F><M><V><P><L><G><V><I><T><T><S><Y><L><L><L><L><A><F><L><Q><R><R><Q><R><R><R><Q><D><S><R><V><V><A><R><S><V><R><I><L><V><A><S><F><F><L><C><W><F><P><N><H><V><V><T><L><W><G><V><L><V><K><F><D><L><V><P><W><N><S><T><F><Y><T><I><Q><T><Y><V><F><P><V><T><T><C><L><A><H><S><N><S><C><L><N><P><V><L><Y><C><L><L><R><R><E><P><R><Q><A><L><A><G><T><F><R><D><L><R><L><R><L><W><P><Q><G><G><G><W><V><Q><Q><V><A><L><K><Q><V><G><R><R><W><V><A><S><N><P><R><E><S><R><P><S><T><L><L><T><N><L><D><R><G><T><P><G>
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.<BOP>
Q8TDU9
Q9UKU9
ANGL2_HUMAN
Angiopoietin-like protein 2
Homo
<M><R><P><L><C><V><T><C><W><W><L><G><L><L><A><A><M><G><A><V><A><G><Q><E><D><G><F><E><G><T><E><E><G><S><P><R><E><F><I><Y><L><N><R><Y><K><R><A><G><E><S><Q><D><K><C><T><Y><T><F><I><V><P><Q><Q><R><V><T><G><A><I><C><V><N><S><K><E><P><E><V><L><L><E><N><R><V><H><K><Q><E><L><E><L><L><N><N><E><L><L><K><Q><K><R><Q><I><E><T><L><Q><Q><L><V><E><V><D><G><G><I><V><S><E><V><K><L><L><R><K><E><S><R><N><M><N><S><R><V><T><Q><L><Y><M><Q><L><L><H><E><I><I><R><K><R><D><N><A><L><E><L><S><Q><L><E><N><R><I><L><N><Q><T><A><D><M><L><Q><L><A><S><K><Y><K><D><L><E><H><K><Y><Q><H><L><A><T><L><A><H><N><Q><S><E><I><I><A><Q><L><E><E><H><C><Q><R><V><P><S><A><R><P><V><P><Q><P><P><P><A><A><P><P><R><V><Y><Q><P><P><T><Y><N><R><I><I><N><Q><I><S><T><N><E><I><Q><S><D><Q><N><L><K><V><L><P><P><P><L><P><T><M><P><T><L><T><S><L><P><S><S><T><D><K><P><S><G><P><W><R><D><C><L><Q><A><L><E><D><G><H><D><T><S><S><I><Y><L><V><K><P><E><N><T><N><R><L><M><Q><V><W><C><D><Q><R><H><D><P><G><G><W><T><V><I><Q><R><R><L><D><G><S><V><N><F><F><R><N><W><E><T><Y><K><Q><G><F><G><N><I><D><G><E><Y><W><L><G><L><E><N><I><Y><W><L><T><N><Q><G><N><Y><K><L><L><V><T><M><E><D><W><S><G><R><K><V><F><A><E><Y><A><S><F><R><L><E><P><E><S><E><Y><Y><K><L><R><L><G><R><Y><H><G><N><A><G><D><S><F><T><W><H><N><G><K><Q><F><T><T><L><D><R><D><H><D><V><Y><T><G><N><C><A><H><Y><Q><K><G><G><W><W><Y><N><A><C><A><H><S><N><L><N><G><V><W><Y><R><G><G><H><Y><R><S><R><Y><Q><D><G><V><Y><W><A><E><F><R><G><G><S><Y><S><L><K><K><V><V><M><M><I><R><P><N><P><N><T><F><H>
Induces sprouting in endothelial cells through an autocrine and paracrine action.<BOP>
Q9UKU9
Q6P1L6
ZN343_HUMAN
Zinc finger protein 343
Homo
<M><M><L><P><Y><P><S><A><L><G><D><Q><Y><W><E><E><I><L><L><P><K><N><G><E><N><V><E><T><M><K><K><L><T><Q><N><H><K><A><K><G><L><P><S><N><D><T><D><C><P><Q><K><K><E><G><K><A><Q><I><V><V><P><V><T><F><R><D><V><T><V><I><F><T><E><A><E><W><K><R><L><S><P><E><Q><R><N><L><Y><K><E><V><M><L><E><N><Y><R><N><L><L><S><L><A><E><P><K><P><E><I><Y><T><C><S><S><C><L><L><A><F><S><C><Q><Q><F><L><S><Q><H><V><L><Q><I><F><L><G><L><C><A><E><N><H><F><H><P><G><N><S><S><P><G><H><W><K><Q><Q><G><Q><Q><Y><S><H><V><S><C><W><F><E><N><A><E><G><Q><E><R><G><G><G><S><K><P><W><S><A><R><T><E><E><R><E><T><S><R><A><F><P><S><P><L><Q><R><Q><S><A><S><P><R><K><G><N><M><V><V><E><T><E><P><S><S><A><Q><R><P><N><P><V><Q><L><D><K><G><L><K><E><L><E><T><L><R><F><G><A><I><N><C><R><E><Y><E><P><D><H><N><L><E><S><N><F><I><T><N><P><R><T><L><L><G><K><K><P><Y><I><C><S><D><C><G><R><S><F><K><D><R><S><T><L><I><R><H><H><R><I><H><S><M><E><K><P><Y><V><C><S><E><C><G><R><G><F><S><Q><K><S><N><L><S><R><H><Q><R><T><H><S><E><E><K><P><Y><L><C><R><E><C><G><Q><S><F><R><S><K><S><I><L><N><R><H><Q><W><T><H><S><E><E><K><P><Y><V><C><S><E><C><G><R><G><F><S><E><K><S><S><F><I><R><H><Q><R><T><H><S><G><E><K><P><Y><V><C><L><E><C><G><R><S><F><C><D><K><S><T><L><R><K><H><Q><R><I><H><S><G><E><K><P><Y><V><C><R><E><C><G><R><G><F><S><Q><N><S><D><L><I><K><H><Q><R><T><H><L><D><E><K><P><Y><V><C><R><E><C><G><R><G><F><C><D><K><S><T><L><I><I><H><E><R><T><H><S><G><E><K><P><Y><V><C><G><E><C><G><R><G><F><S><R><K><S><L><L><L><V><H><Q><R><T><H><S><G><E><K><H><Y><V><C><R><E><C><R><R><G><F><S><Q><K><S><N><L><I><R><H><Q><R><T><H><S><N><E><K><P><Y><I><C><R><E><C><G><R><G><F><C><D><K><S><T><L><I><V><H><E><R><T><H><S><G><E><K><P><Y><V><C><S><E><C><G><R><G><F><S><R><K><S><L><L><L><V><H><Q><R><T><H><S><G><E><K><H><Y><V><C><R><E><C><G><R><G><F><S><H><K><S><N><L><I><R><H><Q><R><T><H>
May be involved in transcriptional regulation.<BOP>
Q6P1L6
Q9UI14
PRAF1_HUMAN
PRA1 family protein 1
Homo
<M><A><A><Q><K><D><Q><Q><K><D><A><E><A><E><G><L><S><G><T><T><L><L><P><K><L><I><P><S><G><A><G><R><E><W><L><E><R><R><R><A><T><I><R><P><W><S><T><F><V><D><Q><Q><R><F><S><R><P><R><N><L><G><E><L><C><Q><R><L><V><R><N><V><E><Y><Y><Q><S><N><Y><V><F><V><F><L><G><L><I><L><Y><C><V><V><T><S><P><M><L><L><V><A><L><A><V><F><F><G><A><C><Y><I><L><Y><L><R><T><L><E><S><K><L><V><L><F><G><R><E><V><S><P><A><H><Q><Y><A><L><A><G><G><I><S><F><P><F><F><W><L><A><G><A><G><S><A><V><F><W><V><L><G><A><T><L><V><V><I><G><S><H><A><A><F><H><Q><I><E><A><V><D><G><E><E><L><Q><M><E><P><V>
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.<BOP>
Q9UI14
P78334
GBRE_HUMAN
GABA(A) receptor subunit epsilon
Homo
<M><L><S><K><V><L><P><V><L><L><G><I><L><L><I><L><Q><S><R><V><E><G><P><Q><T><E><S><K><N><E><A><S><S><R><D><V><V><Y><G><P><Q><P><Q><P><L><E><N><Q><L><L><S><E><E><T><K><S><T><E><T><E><T><G><S><R><V><G><K><L><P><E><A><S><R><I><L><N><T><I><L><S><N><Y><D><H><K><L><R><P><G><I><G><E><K><P><T><V><V><T><V><E><I><S><V><N><S><L><G><P><L><S><I><L><D><M><E><Y><T><I><D><I><I><F><S><Q><T><W><Y><D><E><R><L><C><Y><N><D><T><F><E><S><L><V><L><N><G><N><V><V><S><Q><L><W><I><P><D><T><F><F><R><N><S><K><R><T><H><E><H><E><I><T><M><P><N><Q><M><V><R><I><Y><K><D><G><K><V><L><Y><T><I><R><M><T><I><D><A><G><C><S><L><H><M><L><R><F><P><M><D><S><H><S><C><P><L><S><F><S><S><F><S><Y><P><E><N><E><M><I><Y><K><W><E><N><F><K><L><E><I><N><E><K><N><S><W><K><L><F><Q><F><D><F><T><G><V><S><N><K><T><E><I><I><T><T><P><V><G><D><F><M><V><M><T><I><F><F><N><V><S><R><R><F><G><Y><V><A><F><Q><N><Y><V><P><S><S><V><T><T><M><L><S><W><V><S><F><W><I><K><T><E><S><A><P><A><R><T><S><L><G><I><T><S><V><L><T><M><T><T><L><G><T><F><S><R><K><N><F><P><R><V><S><Y><I><T><A><L><D><F><Y><I><A><I><C><F><V><F><C><F><C><A><L><L><E><F><A><V><L><N><F><L><I><Y><N><Q><T><K><A><H><A><S><P><K><L><R><H><P><R><I><N><S><R><A><H><A><R><T><R><A><R><S><R><A><C><A><R><Q><H><Q><E><A><F><V><C><Q><I><V><T><T><E><G><S><D><G><E><E><R><P><S><C><S><A><Q><Q><P><P><S><P><G><S><P><E><G><P><R><S><L><C><S><K><L><A><C><C><E><W><C><K><R><F><K><K><Y><F><C><M><V><P><D><C><E><G><S><T><W><Q><Q><G><R><L><C><I><H><V><Y><R><L><D><N><Y><S><R><V><V><F><P><V><T><F><F><F><F><N><V><L><Y><W><L><V><C><L><N><L>
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP>
P78334
Q14790
CASP8_HUMAN
Caspase-8 subunit p10
Homo
<M><D><F><S><R><N><L><Y><D><I><G><E><Q><L><D><S><E><D><L><A><S><L><K><F><L><S><L><D><Y><I><P><Q><R><K><Q><E><P><I><K><D><A><L><M><L><F><Q><R><L><Q><E><K><R><M><L><E><E><S><N><L><S><F><L><K><E><L><L><F><R><I><N><R><L><D><L><L><I><T><Y><L><N><T><R><K><E><E><M><E><R><E><L><Q><T><P><G><R><A><Q><I><S><A><Y><R><V><M><L><Y><Q><I><S><E><E><V><S><R><S><E><L><R><S><F><K><F><L><L><Q><E><E><I><S><K><C><K><L><D><D><D><M><N><L><L><D><I><F><I><E><M><E><K><R><V><I><L><G><E><G><K><L><D><I><L><K><R><V><C><A><Q><I><N><K><S><L><L><K><I><I><N><D><Y><E><E><F><S><K><E><R><S><S><S><L><E><G><S><P><D><E><F><S><N><G><E><E><L><C><G><V><M><T><I><S><D><S><P><R><E><Q><D><S><E><S><Q><T><L><D><K><V><Y><Q><M><K><S><K><P><R><G><Y><C><L><I><I><N><N><H><N><F><A><K><A><R><E><K><V><P><K><L><H><S><I><R><D><R><N><G><T><H><L><D><A><G><A><L><T><T><T><F><E><E><L><H><F><E><I><K><P><H><D><D><C><T><V><E><Q><I><Y><E><I><L><K><I><Y><Q><L><M><D><H><S><N><M><D><C><F><I><C><C><I><L><S><H><G><D><K><G><I><I><Y><G><T><D><G><Q><E><A><P><I><Y><E><L><T><S><Q><F><T><G><L><K><C><P><S><L><A><G><K><P><K><V><F><F><I><Q><A><C><Q><G><D><N><Y><Q><K><G><I><P><V><E><T><D><S><E><E><Q><P><Y><L><E><M><D><L><S><S><P><Q><T><R><Y><I><P><D><E><A><D><F><L><L><G><M><A><T><V><N><N><C><V><S><Y><R><N><P><A><E><G><T><W><Y><I><Q><S><L><C><Q><S><L><R><E><R><C><P><R><G><D><D><I><L><T><I><L><T><E><V><N><Y><E><V><S><N><K><D><D><K><K><N><M><G><K><Q><M><P><Q><P><T><F><T><L><R><K><K><L><V><F><P><S><D>
Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex.<BOP>
Q14790
Q14393
GAS6_HUMAN
AXL receptor tyrosine kinase ligand
Homo
<M><A><P><S><L><S><P><G><P><A><A><L><R><R><A><P><Q><L><L><L><L><L><L><A><A><E><C><A><L><A><A><L><L><P><A><R><E><A><T><Q><F><L><R><P><R><Q><R><R><A><F><Q><V><F><E><E><A><K><Q><G><H><L><E><R><E><C><V><E><E><L><C><S><R><E><E><A><R><E><V><F><E><N><D><P><E><T><D><Y><F><Y><P><R><Y><L><D><C><I><N><K><Y><G><S><P><Y><T><K><N><S><G><F><A><T><C><V><Q><N><L><P><D><Q><C><T><P><N><P><C><D><R><K><G><T><Q><A><C><Q><D><L><M><G><N><F><F><C><L><C><K><A><G><W><G><G><R><L><C><D><K><D><V><N><E><C><S><Q><E><N><G><G><C><L><Q><I><C><H><N><K><P><G><S><F><H><C><S><C><H><S><G><F><E><L><S><S><D><G><R><T><C><Q><D><I><D><E><C><A><D><S><E><A><C><G><E><A><R><C><K><N><L><P><G><S><Y><S><C><L><C><D><E><G><F><A><Y><S><S><Q><E><K><A><C><R><D><V><D><E><C><L><Q><G><R><C><E><Q><V><C><V><N><S><P><G><S><Y><T><C><H><C><D><G><R><G><G><L><K><L><S><Q><D><M><D><T><C><E><D><I><L><P><C><V><P><F><S><V><A><K><S><V><K><S><L><Y><L><G><R><M><F><S><G><T><P><V><I><R><L><R><F><K><R><L><Q><P><T><R><L><V><A><E><F><D><F><R><T><F><D><P><E><G><I><L><L><F><A><G><G><H><Q><D><S><T><W><I><V><L><A><L><R><A><G><R><L><E><L><Q><L><R><Y><N><G><V><G><R><V><T><S><S><G><P><V><I><N><H><G><M><W><Q><T><I><S><V><E><E><L><A><R><N><L><V><I><K><V><N><R><D><A><V><M><K><I><A><V><A><G><D><L><F><Q><P><E><R><G><L><Y><H><L><N><L><T><V><G><G><I><P><F><H><E><K><D><L><V><Q><P><I><N><P><R><L><D><G><C><M><R><S><W><N><W><L><N><G><E><D><T><T><I><Q><E><T><V><K><V><N><T><R><M><Q><C><F><S><V><T><E><R><G><S><F><Y><P><G><S><G><F><A><F><Y><S><L><D><Y><M><R><T><P><L><D><V><G><T><E><S><T><W><E><V><E><V><V><A><H><I><R><P><A><A><D><T><G><V><L><F><A><L><W><A><P><D><L><R><A><V><P><L><S><V><A><L><V><D><Y><H><S><T><K><K><L><K><K><Q><L><V><V><L><A><V><E><H><T><A><L><A><L><M><E><I><K><V><C><D><G><Q><E><H><V><V><T><V><S><L><R><D><G><E><A><T><L><E><V><D><G><T><R><G><Q><S><E><V><S><A><A><Q><L><Q><E><R><L><A><V><L><E><R><H><L><R><S><P><V><L><T><F><A><G><G><L><P><D><V><P><V><T><S><A><P><V><T><A><F><Y><R><G><C><M><T><L><E><V><N><R><R><L><L><D><L><D><E><A><A><Y><K><H><S><D><I><T><A><H><S><C><P><P><V><E><P><A><A><A>
(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry . Plays a role in Dengue cell entry by apoptotic mimicry . Plays a role in Vaccinia virus cell entry by apoptotic mimicry . Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry .<BOP>
Q14393
Q9UG22
GIMA2_HUMAN
Immunity-associated protein 2
Homo
<M><D><Q><N><E><H><S><H><W><G><P><H><A><K><G><Q><C><A><S><R><S><E><L><R><I><I><L><V><G><K><T><G><T><G><K><S><A><A><G><N><S><I><L><R><K><Q><A><F><E><S><K><L><G><S><Q><T><L><T><K><T><C><S><K><S><Q><G><S><W><G><N><R><E><I><V><I><I><D><T><P><D><M><F><S><W><K><D><H><C><E><A><L><Y><K><E><V><Q><R><C><Y><L><L><S><A><P><G><P><H><V><L><L><L><V><T><Q><L><G><R><Y><T><S><Q><D><Q><Q><A><A><Q><R><V><K><E><I><F><G><E><D><A><M><G><H><T><I><V><L><F><T><H><K><E><D><L><N><G><G><S><L><M><D><Y><M><H><D><S><D><N><K><A><L><S><K><L><V><A><A><C><G><G><R><I><C><A><F><N><N><R><A><E><G><S><N><Q><D><D><Q><V><K><E><L><M><D><C><I><E><D><L><L><M><E><K><N><G><D><H><Y><T><N><G><L><Y><S><L><I><Q><R><S><K><C><G><P><V><G><S><D><E><R><V><K><E><F><K><Q><S><L><I><K><Y><M><E><T><Q><R><S><Y><T><A><L><A><E><A><N><C><L><K><G><A><L><I><K><T><Q><L><C><V><L><F><C><I><Q><L><F><L><R><L><I><I><L><W><L><C><I><L><H><S><M><C><N><L><F><C><C><L><L><F><S><M><C><N><L><F><C><S><L><L><F><I><I><P><K><K><L><M><I><F><L><R><T><V><I><R><L><E><R><K><T><P><R><L>
The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.<BOP>
Q9UG22
O60479
DLX3_HUMAN
Homeobox protein DLX-3
Homo
<M><S><G><S><F><D><R><K><L><S><S><I><L><T><D><I><S><S><S><L><S><C><H><A><G><S><K><D><S><P><T><L><P><E><S><S><V><T><D><L><G><Y><Y><S><A><P><Q><H><D><Y><Y><S><G><Q><P><Y><G><Q><T><V><N><P><Y><T><Y><H><H><Q><F><N><L><N><G><L><A><G><T><G><A><Y><S><P><K><S><E><Y><T><Y><G><A><S><Y><R><Q><Y><G><A><Y><R><E><Q><P><L><P><A><Q><D><P><V><S><V><K><E><E><P><E><A><E><V><R><M><V><N><G><K><P><K><K><V><R><K><P><R><T><I><Y><S><S><Y><Q><L><A><A><L><Q><R><R><F><Q><K><A><Q><Y><L><A><L><P><E><R><A><E><L><A><A><Q><L><G><L><T><Q><T><Q><V><K><I><W><F><Q><N><R><R><S><K><F><K><K><L><Y><K><N><G><E><V><P><L><E><H><S><P><N><N><S><D><S><M><A><C><N><S><P><P><S><P><A><L><W><D><T><S><S><H><S><T><P><A><P><A><R><S><Q><L><P><P><P><L><P><Y><S><A><S><P><S><Y><L><D><D><P><T><N><S><W><Y><H><A><Q><N><L><S><G><P><H><L><Q><Q><Q><P><P><Q><P><A><T><L><H><H><A><S><P><G><P><P><P><N><P><G><A><V><Y>
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.<BOP>
O60479
Q8WW27
ABEC4_HUMAN
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Homo
<M><E><P><I><Y><E><E><Y><L><A><N><H><G><T><I><V><K><P><Y><Y><W><L><S><F><S><L><D><C><S><N><C><P><Y><H><I><R><T><G><E><E><A><R><V><S><L><T><E><F><C><Q><I><F><G><F><P><Y><G><T><T><F><P><Q><T><K><H><L><T><F><Y><E><L><K><T><S><S><G><S><L><V><Q><K><G><H><A><S><S><C><T><G><N><Y><I><H><P><E><S><M><L><F><E><M><N><G><Y><L><D><S><A><I><Y><N><N><D><S><I><R><H><I><I><L><Y><S><N><N><S><P><C><N><E><A><N><H><C><C><I><S><K><M><Y><N><F><L><I><T><Y><P><G><I><T><L><S><I><Y><F><S><Q><L><Y><H><T><E><M><D><F><P><A><S><A><W><N><R><E><A><L><R><S><L><A><S><L><W><P><R><V><V><L><S><P><I><S><G><G><I><W><H><S><V><L><H><S><F><I><S><G><V><S><G><S><H><V><F><Q><P><I><L><T><G><R><A><L><A><D><R><H><N><A><Y><E><I><N><A><I><T><G><V><K><P><Y><F><T><D><V><L><L><Q><T><K><R><N><P><N><T><K><A><Q><E><A><L><E><S><Y><P><L><N><N><A><F><P><G><Q><F><F><Q><M><P><S><G><Q><L><Q><P><N><L><P><P><D><L><R><A><P><V><V><F><V><L><V><P><L><R><D><L><P><P><M><H><M><G><Q><N><P><N><K><P><R><N><I><V><R><H><L><N><M><P><Q><M><S><F><Q><E><T><K><D><L><G><R><L><P><T><G><R><S><V><E><I><V><E><I><T><E><Q><F><A><S><S><K><E><A><D><E><K><K><K><K><K><G><K><K>
Putative C to U editing enzyme whose physiological substrate is not yet known.<BOP>
Q8WW27
Q96IL0
COA8_HUMAN
Apoptogenic protein 1, mitochondrial
Homo
<M><L><P><C><A><A><G><A><R><G><R><G><A><M><V><V><L><R><A><G><K><K><T><F><L><P><P><L><C><R><A><F><A><C><R><G><C><Q><L><A><P><E><R><G><A><E><R><R><D><T><A><P><S><G><V><S><R><F><C><P><P><R><K><S><C><H><D><W><I><G><P><P><D><K><Y><S><N><L><R><P><V><H><F><Y><I><P><E><N><E><S><P><L><E><Q><K><L><R><K><L><R><Q><E><T><Q><E><W><N><Q><Q><F><W><A><N><Q><N><L><T><F><S><K><E><K><E><E><F><I><H><S><R><L><K><T><K><G><L><G><L><R><T><E><S><G><Q><K><A><T><L><N><A><E><E><M><A><D><F><Y><K><E><F><L><S><K><N><F><Q><K><H><M><Y><Y><N><R><D><W><Y><K><R><N><F><A><I><T><F><F><M><G><K><V><A><L><E><R><I><W><N><K><L><K><Q><K><Q><K><K><R><S><N>
Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain.<BOP>
Q96IL0
Q8WTV0
SCRB1_HUMAN
SR-BI
Homo
<M><G><C><S><A><K><A><R><W><A><A><G><A><L><G><V><A><G><L><L><C><A><V><L><G><A><V><M><I><V><M><V><P><S><L><I><K><Q><Q><V><L><K><N><V><R><I><D><P><S><S><L><S><F><N><M><W><K><E><I><P><I><P><F><Y><L><S><V><Y><F><F><D><V><M><N><P><S><E><I><L><K><G><E><K><P><Q><V><R><E><R><G><P><Y><V><Y><R><E><F><R><H><K><S><N><I><T><F><N><N><N><D><T><V><S><F><L><E><Y><R><T><F><Q><F><Q><P><S><K><S><H><G><S><E><S><D><Y><I><V><M><P><N><I><L><V><L><G><A><A><V><M><M><E><N><K><P><M><T><L><K><L><I><M><T><L><A><F><T><T><L><G><E><R><A><F><M><N><R><T><V><G><E><I><M><W><G><Y><K><D><P><L><V><N><L><I><N><K><Y><F><P><G><M><F><P><F><K><D><K><F><G><L><F><A><E><L><N><N><S><D><S><G><L><F><T><V><F><T><G><V><Q><N><I><S><R><I><H><L><V><D><K><W><N><G><L><S><K><V><D><F><W><H><S><D><Q><C><N><M><I><N><G><T><S><G><Q><M><W><P><P><F><M><T><P><E><S><S><L><E><F><Y><S><P><E><A><C><R><S><M><K><L><M><Y><K><E><S><G><V><F><E><G><I><P><T><Y><R><F><V><A><P><K><T><L><F><A><N><G><S><I><Y><P><P><N><E><G><F><C><P><C><L><E><S><G><I><Q><N><V><S><T><C><R><F><S><A><P><L><F><L><S><H><P><H><F><L><N><A><D><P><V><L><A><E><A><V><T><G><L><H><P><N><Q><E><A><H><S><L><F><L><D><I><H><P><V><T><G><I><P><M><N><C><S><V><K><L><Q><L><S><L><Y><M><K><S><V><A><G><I><G><Q><T><G><K><I><E><P><V><V><L><P><L><L><W><F><A><E><S><G><A><M><E><G><E><T><L><H><T><F><Y><T><Q><L><V><L><M><P><K><V><M><H><Y><A><Q><Y><V><L><L><A><L><G><C><V><L><L><L><V><P><V><I><C><Q><I><R><S><Q><V><G><A><G><Q><R><A><A><R><A><D><S><H><S><L><A><C><W><G><K><G><A><S><D><R><T><L><W><P><T><A><A><W><S><P><P><P><A><A><V><L><R><L><C><R><S><G><S><G><H><C><W><G><L><R><S><T><L><A><S><F><A><C><R><V><A><T><T><L><P><V><L><E><G><L><G><P><S><L><G><G><G><T><G><S>
(Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.<BOP>
Q8WTV0
P55107
GDF10_HUMAN
Bone-inducing protein
Homo
<M><A><H><V><P><A><R><T><S><P><G><P><G><P><Q><L><L><L><L><L><L><P><L><F><L><L><L><L><R><D><V><A><G><S><H><R><A><P><A><W><S><A><L><P><A><A><A><D><G><L><Q><G><D><R><D><L><Q><R><H><P><G><D><A><A><A><T><L><G><P><S><A><Q><D><M><V><A><V><H><M><H><R><L><Y><E><K><Y><S><R><Q><G><A><R><P><G><G><G><N><T><V><R><S><F><R><A><R><L><E><V><V><D><Q><K><A><V><Y><F><F><N><L><T><S><M><Q><D><S><E><M><I><L><T><A><T><F><H><F><Y><S><E><P><P><R><W><P><R><A><L><E><V><L><C><K><P><R><A><K><N><A><S><G><R><P><L><P><L><G><P><P><T><R><Q><H><L><L><F><R><S><L><S><Q><N><T><A><T><Q><G><L><L><R><G><A><M><A><L><A><P><P><P><R><G><L><W><Q><A><K><D><I><S><P><I><V><K><A><A><R><R><D><G><E><L><L><L><S><A><Q><L><D><S><E><E><R><D><P><G><V><P><R><P><S><P><Y><A><P><Y><I><L><V><Y><A><N><D><L><A><I><S><E><P><N><S><V><A><V><T><L><Q><R><Y><D><P><F><P><A><G><D><P><E><P><R><A><A><P><N><N><S><A><D><P><R><V><R><R><A><A><Q><A><T><G><P><L><Q><D><N><E><L><P><G><L><D><E><R><P><P><R><A><H><A><Q><H><F><H><K><H><Q><L><W><P><S><P><F><R><A><L><K><P><R><P><G><R><K><D><R><R><K><K><G><Q><E><V><F><M><A><A><S><Q><V><L><D><F><D><E><K><T><M><Q><K><A><R><R><K><Q><W><D><E><P><R><V><C><S><R><R><Y><L><K><V><D><F><A><D><I><G><W><N><E><W><I><I><S><P><K><S><F><D><A><Y><Y><C><A><G><A><C><E><F><P><M><P><K><I><V><R><P><S><N><H><A><T><I><Q><S><I><V><R><A><V><G><I><I><P><G><I><P><E><P><C><C><V><P><D><K><M><N><S><L><G><V><L><F><L><D><E><N><R><N><V><V><L><K><V><Y><P><N><M><S><V><D><T><C><A><C><R>
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.<BOP>
P55107
Q8NA47
CCD63_HUMAN
Coiled-coil domain-containing protein 63
Homo
<M><S><V><L><K><K><N><R><R><K><D><S><D><T><P><Q><E><P><S><E><K><A><K><E><Q><Q><A><E><A><E><L><R><K><L><R><Q><Q><F><R><K><M><V><E><S><R><K><S><F><K><F><R><N><Q><Q><K><I><A><S><Q><Y><K><E><I><K><T><L><K><T><E><Q><D><E><I><T><L><L><L><S><L><M><K><S><S><R><N><M><N><R><S><E><K><N><Y><M><E><L><R><L><L><L><Q><T><K><E><D><Y><E><A><L><I><K><S><L><K><V><L><L><A><E><L><D><E><K><I><L><Q><M><E><K><K><I><A><N><Q><K><Q><I><F><A><K><M><Q><E><A><N><N><P><R><K><L><Q><K><Q><I><H><I><L><E><T><R><L><N><L><V><T><V><H><F><D><K><M><L><T><T><N><A><K><L><R><K><E><I><E><D><L><R><F><E><K><A><A><Y><D><N><V><Y><Q><Q><L><Q><H><C><L><L><M><E><K><K><T><M><N><L><A><I><E><Q><S><S><Q><A><Y><E><Q><R><V><E><A><M><A><R><M><A><A><M><K><D><R><Q><K><K><D><T><S><Q><Y><N><L><E><I><R><E><L><E><R><L><Y><A><H><E><S><K><L><K><S><F><L><L><V><K><L><N><D><R><N><E><F><E><E><Q><A><K><R><E><E><A><L><K><A><K><K><H><V><K><K><N><R><G><E><S><F><E><S><Y><E><V><A><H><L><R><L><L><K><L><A><E><S><G><N><L><N><Q><L><I><E><D><F><L><A><K><E><E><K><N><F><A><R><F><T><Y><V><T><E><L><N><N><D><M><E><M><M><H><K><R><T><Q><R><I><Q><D><E><I><I><L><L><R><S><Q><Q><K><L><S><H><D><D><N><H><S><V><L><R><Q><L><E><D><K><L><R><K><T><T><E><E><A><D><M><Y><E><S><K><Y><G><E><V><S><K><T><L><D><L><L><K><N><S><V><E><K><L><F><K><K><I><N><C><D><A><T><K><I><L><V><Q><L><G><E><T><G><K><V><T><D><I><N><L><P><Q><Y><F><A><I><I><E><K><K><T><N><D><L><L><L><L><E><T><Y><R><R><I><L><E><V><E><G><A><E><A><E><I><P><P><P><F><I><N><P><F><W><G><G><S><A><L><L><K><P><P><E><P><I><K><V><I><P><P><V><L><G><A><D><P><F><S><D><R><L><D><D><V><E><Q><P><L><D><H><S><S><L><R><Q><L><V><L><D><N><Y><I><L><K><E><N><R><S><K><E><V><R><G><D><S><L><P><E><K><V><D><D><F><R><S><R><K><K><V><T><M>
Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.<BOP>
Q8NA47
Q99675
CGRF1_HUMAN
RING finger protein 197
Homo
<M><A><A><V><F><L><V><T><L><Y><E><Y><S><P><L><F><Y><I><A><V><V><F><T><C><F><I><V><T><T><G><L><V><L><G><W><F><G><W><D><V><P><V><I><L><R><N><S><E><E><T><Q><F><S><T><R><V><F><K><K><Q><M><R><Q><V><K><N><P><F><G><L><E><I><T><N><P><S><S><A><S><I><T><T><G><I><T><L><T><T><D><C><L><E><D><S><L><L><T><C><Y><W><G><C><S><V><Q><K><L><Y><E><A><L><Q><K><H><V><Y><C><F><R><I><S><T><P><Q><A><L><E><D><A><L><Y><S><E><Y><L><Y><Q><E><Q><Y><F><I><K><K><D><S><K><E><E><I><Y><C><Q><L><P><R><D><T><K><I><E><D><F><G><T><V><P><R><S><R><Y><P><L><V><A><L><L><T><L><A><D><E><D><D><R><E><I><Y><D><I><I><S><M><V><S><V><I><H><I><P><D><R><T><Y><K><L><S><C><R><I><L><Y><Q><Y><L><L><L><A><Q><G><Q><F><H><D><L><K><Q><L><F><M><S><A><N><N><N><F><T><P><S><N><N><S><S><S><E><E><K><N><T><D><R><S><L><L><E><K><V><G><L><S><E><S><E><V><E><P><S><E><E><N><S><K><D><C><V><V><C><Q><N><G><T><V><N><W><V><L><L><P><C><R><H><T><C><L><C><D><G><C><V><K><Y><F><Q><Q><C><P><M><C><R><Q><F><V><Q><E><S><F><A><L><C><S><Q><K><E><Q><D><K><D><K><P><K><T><L>
Able to inhibit growth in several cell lines.<BOP>
Q99675
Q9H2R5
KLK15_HUMAN
ACO protease
Homo
<M><W><L><L><L><T><L><S><F><L><L><A><S><T><A><A><Q><D><G><D><K><L><L><E><G><D><E><C><A><P><H><S><Q><P><W><Q><V><A><L><Y><E><R><G><R><F><N><C><G><A><S><L><I><S><P><H><W><V><L><S><A><A><H><C><Q><S><R><F><M><R><V><R><L><G><E><H><N><L><R><K><R><D><G><P><E><Q><L><R><T><T><S><R><V><I><P><H><P><R><Y><E><A><R><S><H><R><N><D><I><M><L><L><R><L><V><Q><P><A><R><L><N><P><Q><V><R><P><A><V><L><P><T><R><C><P><H><P><G><E><A><C><V><V><S><G><W><G><L><V><S><H><N><E><P><G><T><A><G><S><P><R><S><Q><V><S><L><P><D><T><L><H><C><A><N><I><S><I><I><S><D><T><S><C><D><K><S><Y><P><G><R><L><T><N><T><M><V><C><A><G><A><E><G><R><G><A><E><S><C><E><G><D><S><G><G><P><L><V><C><G><G><I><L><Q><G><I><V><S><W><G><D><V><P><C><D><N><T><T><K><P><G><V><Y><T><K><V><C><H><Y><L><E><W><I><R><E><T><M><K><R><N>
Protease whose physiological substrate is not yet known.<BOP>
Q9H2R5
P51398
RT29_HUMAN
Mitochondrial small ribosomal subunit protein mS29
Homo
<M><M><L><K><G><I><T><R><L><I><S><R><I><H><K><L><D><P><G><R><F><L><H><M><G><T><Q><A><R><Q><S><I><A><A><H><L><D><N><Q><V><P><V><E><S><P><R><A><I><S><R><T><N><E><N><D><P><A><K><H><G><D><Q><H><E><G><Q><H><Y><N><I><S><P><Q><D><L><E><T><V><F><P><H><G><L><P><P><R><F><V><M><Q><V><K><T><F><S><E><A><C><L><M><V><R><K><P><A><L><E><L><L><H><Y><L><K><N><T><S><F><A><Y><P><A><I><R><Y><L><L><Y><G><E><K><G><T><G><K><T><L><S><L><C><H><V><I><H><F><C><A><K><Q><D><W><L><I><L><H><I><P><D><A><H><L><W><V><K><N><C><R><D><L><L><Q><S><S><Y><N><K><Q><R><F><D><Q><P><L><E><A><S><T><W><L><K><N><F><K><T><T><N><E><R><F><L><N><Q><I><K><V><Q><E><K><Y><V><W><N><K><R><E><S><T><E><K><G><S><P><L><G><E><V><V><E><Q><G><I><T><R><V><R><N><A><T><D><A><V><G><I><V><L><K><E><L><K><R><Q><S><S><L><G><M><F><H><L><L><V><A><V><D><G><I><N><A><L><W><G><R><T><T><L><K><R><E><D><K><S><P><I><A><P><E><E><L><A><L><V><H><N><L><R><K><M><M><K><N><D><W><H><G><G><A><I><V><S><A><L><S><Q><T><G><S><L><F><K><P><R><K><A><Y><L><P><Q><E><L><L><G><K><E><G><F><D><A><L><D><P><F><I><P><I><L><V><S><N><Y><N><P><K><E><F><E><S><C><I><Q><Y><Y><L><E><N><N><W><L><Q><H><E><K><A><P><T><E><E><G><K><K><E><L><L><F><L><S><N><A><N><P><S><L><L><E><R><H><C><A><Y><L>
Involved in mediating interferon-gamma-induced cell death.<BOP>
P51398
Q8WU76
SCFD2_HUMAN
Syntaxin-binding protein 1-like 1
Homo
<M><S><A><S><G><V><L><S><F><T><Q><Q><G><W><E><Q><V><L><A><K><V><K><R><A><V><V><Y><L><D><A><A><C><A><E><S><L><H><W><G><C><G><S><T><R><L><L><E><A><V><G><G><P><D><C><H><L><R><E><F><E><P><D><A><I><G><G><G><A><K><Q><P><K><A><V><F><V><L><S><C><L><L><K><G><R><T><V><E><I><L><R><D><I><I><C><R><S><H><F><Q><Y><C><V><V><V><T><T><V><S><H><A><V><H><L><T><A><N><H><V><P><A><A><A><A><A><E><M><E><G><Q><Q><P><V><F><E><Q><L><E><E><K><L><C><E><W><M><G><N><M><N><Y><T><A><E><V><F><H><V><P><L><L><L><A><P><V><A><P><H><F><A><L><T><P><A><F><A><S><L><F><P><L><L><P><Q><D><V><H><L><L><N><S><A><R><P><D><K><R><K><L><G><S><L><G><D><V><D><S><T><T><L><T><P><E><L><L><L><Q><I><R><C><L><V><S><G><L><S><S><L><C><E><H><L><G><V><R><E><E><C><F><A><V><G><S><L><S><Q><V><I><A><A><D><L><A><N><Y><A><P><A><K><N><R><K><K><T><A><A><G><R><A><S><V><V><F><V><D><R><T><L><D><L><T><G><A><V><G><H><H><G><D><N><L><V><E><K><I><I><S><A><L><P><Q><L><P><G><H><T><N><D><V><M><V><N><M><I><A><L><T><A><L><H><T><E><E><E><N><Y><N><V><V><A><P><G><C><L><S><Q><S><S><D><T><T><A><K><A><L><W><E><A><L><L><N><T><K><H><K><E><A><V><M><E><V><R><R><H><L><V><E><A><A><S><R><E><N><L><P><I><K><M><S><M><G><R><V><T><P><G><Q><L><M><S><Y><I><Q><L><F><K><N><N><L><K><A><L><M><N><H><C><G><L><L><Q><L><G><L><A><T><A><Q><T><L><K><H><P><Q><T><A><K><W><D><N><F><L><A><F><E><R><L><L><L><Q><S><I><G><E><S><A><M><S><V><V><L><N><Q><L><L><P><M><I><K><P><V><T><Q><R><T><N><E><D><Y><S><P><E><E><L><L><I><L><L><I><Y><I><Y><S><V><T><G><E><L><T><V><D><K><D><L><C><E><A><E><E><K><V><K><K><A><L><A><Q><V><F><C><E><E><S><G><L><S><P><L><L><Q><K><I><T><D><W><D><S><S><I><N><L><T><F><H><K><S><K><I><A><V><D><E><L><F><T><S><L><R><D><I><A><G><A><R><S><L><L><K><Q><F><K><S><V><Y><V><P><G><N><H><T><H><Q><A><S><Y><K><P><L><L><K><Q><V><V><E><E><I><F><H><P><E><R><P><D><S><V><D><I><E><H><M><S><S><G><L><T><D><L><L><K><T><G><F><S><M><F><M><K><V><S><R><P><H><P><S><D><Y><P><L><L><I><L><F><V><V><G><G><V><T><V><S><E><V><K><M><V><K><D><L><V><A><S><L><K><P><G><T><Q><V><I><V><L><S><T><R><L><L><K><P><L><N><I><P><E><L><L><F><A><T><D><R><L><H><P><D><L><G><F>
May be involved in protein transport.<BOP>
Q8WU76
Q96S94
CCNL2_HUMAN
Paneth cell-enhanced expression protein
Homo
<M><A><A><A><A><A><A><A><G><A><A><G><S><A><A><P><A><A><A><A><G><A><P><G><S><G><G><A><P><S><G><S><Q><G><V><L><I><G><D><R><L><Y><S><G><V><L><I><T><L><E><N><C><L><L><P><D><D><K><L><R><F><T><P><S><M><S><S><G><L><D><T><D><T><E><T><D><L><R><V><V><G><C><E><L><I><Q><A><A><G><I><L><L><R><L><P><Q><V><A><M><A><T><G><Q><V><L><F><Q><R><F><F><Y><T><K><S><F><V><K><H><S><M><E><H><V><S><M><A><C><V><H><L><A><S><K><I><E><E><A><P><R><R><I><R><D><V><I><N><V><F><H><R><L><R><Q><L><R><D><K><K><K><P><V><P><L><L><L><D><Q><D><Y><V><N><L><K><N><Q><I><I><K><A><E><R><R><V><L><K><E><L><G><F><C><V><H><V><K><H><P><H><K><I><I><V><M><Y><L><Q><V><L><E><C><E><R><N><Q><H><L><V><Q><T><S><W><N><Y><M><N><D><S><L><R><T><D><V><F><V><R><F><Q><P><E><S><I><A><C><A><C><I><Y><L><A><A><R><T><L><E><I><P><L><P><N><R><P><H><W><F><L><L><F><G><A><T><E><E><E><I><Q><E><I><C><L><K><I><L><Q><L><Y><A><R><K><K><V><D><L><T><H><L><E><G><E><V><E><K><R><K><H><A><I><E><E><A><K><A><Q><A><R><G><L><L><P><G><G><T><Q><V><L><D><G><T><S><G><F><S><P><A><P><K><L><V><E><S><P><K><E><G><K><G><S><K><P><S><P><L><S><V><K><N><T><K><R><R><L><E><G><A><K><K><A><K><A><D><S><P><V><N><G><L><P><K><G><R><E><S><R><S><R><S><R><S><R><E><Q><S><Y><S><R><S><P><S><R><S><A><S><P><K><R><R><K><S><D><S><G><S><T><S><G><G><S><K><S><Q><S><R><S><R><S><R><S><D><S><P><P><R><Q><A><P><R><S><A><P><Y><K><G><S><E><I><R><G><S><R><K><S><K><D><C><K><Y><P><Q><K><P><H><K><S><R><S><R><S><S><S><R><S><R><S><R><S><R><E><R><A><D><N><P><G><K><Y><K><K><K><S><H><Y><Y><R><D><Q><R><R><E><R><S><R><S><Y><E><R><T><G><R><R><Y><E><R><D><H><P><G><H><S><R><H><R><R>
Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.<BOP>
Q96S94
Q08ER8
ZN543_HUMAN
Zinc finger protein 543
Homo
<M><A><A><S><A><Q><V><S><V><T><F><E><D><V><A><V><T><F><T><Q><E><E><W><G><Q><L><D><A><A><Q><R><T><L><Y><Q><E><V><M><L><E><T><C><G><L><L><M><S><L><G><C><P><L><F><K><P><E><L><I><Y><Q><L><D><H><R><Q><E><L><W><M><A><T><K><D><L><S><Q><S><S><Y><P><G><D><N><T><K><P><K><T><T><E><P><T><F><S><H><L><A><L><P><E><E><V><L><L><Q><E><Q><L><T><Q><G><A><S><K><N><S><Q><L><G><Q><S><K><D><Q><D><G><P><S><E><M><Q><E><V><H><L><K><I><G><I><G><P><Q><R><G><K><L><L><E><K><M><S><S><E><R><D><G><L><G><S><D><D><G><V><C><T><K><I><T><Q><K><Q><V><S><T><E><G><D><L><Y><E><C><D><S><H><G><P><V><T><D><A><L><I><R><E><E><K><N><S><Y><K><C><E><E><C><G><K><V><F><K><K><N><A><L><L><V><Q><H><E><R><I><H><T><Q><V><K><P><Y><E><C><T><E><C><G><K><T><F><S><K><S><T><H><L><L><Q><H><L><I><I><H><T><G><E><K><P><Y><K><C><M><E><C><G><K><A><F><N><R><R><S><H><L><T><R><H><Q><R><I><H><S><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><T><H><R><S><T><F><V><L><H><H><R><S><H><T><G><E><K><P><F><V><C><K><E><C><G><K><A><F><R><D><R><P><G><F><I><R><H><Y><I><I><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><N><R><R><S><Y><L><T><W><H><Q><Q><I><H><T><G><V><K><P><F><E><C><N><E><C><G><K><A><F><C><E><S><A><D><L><I><Q><H><Y><I><I><H><T><G><E><K><P><Y><K><C><M><E><C><G><K><A><F><N><R><R><S><H><L><K><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><T><H><C><S><T><F><V><L><H><K><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><D><R><A><D><L><I><R><H><F><S><I><H><T><G><E><K><P><Y><E><C><V><E><C><G><K><A><F><N><R><S><S><H><L><T><R><H><Q><Q><I><H><T><G><E><K><P><Y><E><C><I><Q><C><G><K><A><F><C><R><S><A><N><L><I><R><H><S><I><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><N><R><G><S><S><L><T><H><H><Q><R><I><H><T><G><R><N><P><T><I><V><T><D><V><G><R><P><F><M><T><A><Q><T><S><V><N><I><Q><E><L><L><L><G><K><E><F><L><N><I><T><T><E><E><N><L><W>
May be involved in transcriptional regulation.<BOP>
Q08ER8
Q13564
ULA1_HUMAN
Proto-oncogene protein 1
Homo
<M><A><Q><L><G><K><L><L><K><E><Q><K><Y><D><R><Q><L><R><L><W><G><D><H><G><Q><E><A><L><E><S><A><H><V><C><L><I><N><A><T><A><T><G><T><E><I><L><K><N><L><V><L><P><G><I><G><S><F><T><I><I><D><G><N><Q><V><S><G><E><D><A><G><N><N><F><F><L><Q><R><S><S><I><G><K><N><R><A><E><A><A><M><E><F><L><Q><E><L><N><S><D><V><S><G><S><F><V><E><E><S><P><E><N><L><L><D><N><D><P><S><F><F><C><R><F><T><V><V><V><A><T><Q><L><P><E><S><T><S><L><R><L><A><D><V><L><W><N><S><Q><I><P><L><L><I><C><R><T><Y><G><L><V><G><Y><M><R><I><I><I><K><E><H><P><V><I><E><S><H><P><D><N><A><L><E><D><L><R><L><D><K><P><F><P><E><L><R><E><H><F><Q><S><Y><D><L><D><H><M><E><K><K><D><H><S><H><T><P><W><I><V><I><I><A><K><Y><L><A><Q><W><Y><S><E><T><N><G><R><I><P><K><T><Y><K><E><K><E><D><F><R><D><L><I><R><Q><G><I><L><K><N><E><N><G><A><P><E><D><E><E><N><F><E><E><A><I><K><N><V><N><T><A><L><N><T><T><Q><I><P><S><S><I><E><D><I><F><N><D><D><R><C><I><N><I><T><K><Q><T><P><S><F><W><I><L><A><R><A><L><K><E><F><V><A><K><E><G><Q><G><N><L><P><V><R><G><T><I><P><D><M><I><A><D><S><G><K><Y><I><K><L><Q><N><V><Y><R><E><K><A><K><K><D><A><A><A><V><G><N><H><V><A><K><L><L><Q><S><I><G><Q><A><P><E><S><I><S><E><K><E><L><K><L><L><C><S><N><S><A><F><L><R><V><V><R><C><R><S><L><A><E><E><Y><G><L><D><T><I><N><K><D><E><I><I><S><S><M><D><N><P><D><N><E><I><V><L><Y><L><M><L><R><A><V><D><R><F><H><K><Q><Q><G><R><Y><P><G><V><S><N><Y><Q><V><E><E><D><I><G><K><L><K><S><C><L><T><G><F><L><Q><E><Y><G><L><S><V><M><V><K><D><D><Y><V><H><E><F><C><R><Y><G><A><A><E><P><H><T><I><A><A><F><L><G><G><A><A><A><Q><E><V><I><K><I><I><T><K><Q><F><V><I><F><N><N><T><Y><I><Y><S><G><M><S><Q><T><S><A><T><F><Q><L>
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.<BOP>
Q13564
Q8NHB7
OR5K1_HUMAN
Olfactory receptor OR3-8
Homo
<M><A><E><E><N><H><T><M><K><N><E><F><I><L><T><G><F><T><D><H><P><E><L><K><T><L><L><F><V><V><F><F><A><I><Y><L><I><T><V><V><G><N><I><S><L><V><A><L><I><F><T><H><R><R><L><H><T><P><M><Y><I><F><L><G><N><L><A><L><V><D><S><C><C><A><C><A><I><T><P><K><M><L><E><N><F><F><S><E><N><K><R><I><S><L><Y><E><C><A><V><Q><F><Y><F><L><C><T><V><E><T><A><D><C><F><L><L><A><A><M><A><Y><D><R><Y><V><A><I><C><N><P><L><Q><Y><H><I><M><M><S><K><K><L><C><I><Q><M><T><T><G><A><F><I><A><G><N><L><H><S><M><I><H><V><G><L><V><F><R><L><V><F><C><G><S><N><H><I><N><H><F><Y><C><D><I><L><P><L><Y><R><L><S><C><V><D><P><Y><I><N><E><L><V><L><F><I><F><S><G><S><V><Q><V><F><T><I><G><S><V><L><I><S><Y><L><Y><I><L><L><T><I><F><K><M><K><S><K><E><G><R><A><K><A><F><S><T><C><A><S><H><F><L><S><V><S><L><F><Y><G><S><L><F><F><M><Y><V><R><P><N><L><L><E><E><G><D><K><D><I><P><A><A><I><L><F><T><I><V><V><P><L><L><N><P><F><I><Y><S><L><R><N><R><E><V><I><S><V><L><R><K><I><L><M><K><K>
Odorant receptor.<BOP>
Q8NHB7
Q8NCE2
MTMRE_HUMAN
hJumpy
Homo
<M><A><G><A><R><A><A><A><A><A><A><S><A><G><S><S><A><S><S><G><N><Q><P><P><Q><E><L><G><L><G><E><L><L><E><E><F><S><R><T><Q><Y><R><A><K><D><G><S><G><T><G><G><S><K><V><E><R><I><E><K><R><C><L><E><L><F><G><R><D><Y><C><F><S><V><I><P><N><T><N><G><D><I><C><G><H><Y><P><R><H><I><V><F><L><E><Y><E><S><S><E><K><E><K><D><T><F><E><S><T><V><Q><V><S><K><L><Q><D><L><I><H><R><S><K><M><A><R><C><R><G><R><F><V><C><P><V><I><L><F><K><G><K><H><I><C><R><S><A><T><L><A><G><W><G><E><L><Y><G><R><S><G><Y><N><Y><F><F><S><G><G><A><D><D><A><W><A><D><V><E><D><V><T><E><E><D><C><A><L><R><S><G><D><T><H><L><F><D><K><V><R><G><Y><D><I><K><L><L><R><Y><L><S><V><K><Y><I><C><D><L><M><V><E><N><K><K><V><K><F><G><M><N><V><T><S><S><E><K><V><D><K><A><Q><R><Y><A><D><F><T><L><L><S><I><P><Y><P><G><C><E><F><F><K><E><Y><K><D><R><D><Y><M><A><E><G><L><I><F><N><W><K><Q><D><Y><V><D><A><P><L><S><I><P><D><F><L><T><H><S><L><N><I><D><W><S><Q><Y><Q><C><W><D><L><V><Q><Q><T><Q><N><Y><L><K><L><L><L><S><L><V><N><S><D><D><D><S><G><L><L><V><H><C><I><S><G><W><D><R><T><P><L><F><I><S><L><L><R><L><S><L><W><A><D><G><L><I><H><T><S><L><K><P><T><E><I><L><Y><L><T><V><A><Y><D><W><F><L><F><G><H><M><L><V><D><R><L><S><K><G><E><E><I><F><F><F><C><F><N><F><L><K><H><I><T><S><E><E><F><S><A><L><K><T><Q><R><R><K><S><L><P><A><R><D><G><G><F><T><L><E><D><I><C><M><L><R><R><K><D><R><G><S><T><T><S><L><G><S><D><F><S><L><V><M><E><S><S><P><G><A><T><G><S><F><T><Y><E><A><V><E><L><V><P><A><G><A><P><T><Q><A><A><W><R><K><S><H><S><S><S><P><Q><S><V><L><W><N><R><P><Q><P><S><E><D><R><L><P><S><Q><Q><G><L><A><E><A><R><S><S><S><S><S><S><S><N><H><S><D><N><F><F><R><M><G><S><S><P><L><E><V><P><K><P><R><S><V><D><H><P><L><P><G><S><S><L><S><T><D><Y><G><S><W><Q><M><V><T><G><C><G><S><I><Q><E><R><A><V><L><H><T><D><S><S><L><P><F><S><F><P><D><E><L><P><N><S><C><L><L><A><A><L><S><D><R><E><T><R><L><Q><E><V><R><S><A><F><L><A><A><Y><S><S><T><V><G><L><R><A><V><A><P><S><P><S><G><A><I><G><G><L><L><E><Q><F><A><R><G><V><G><L><R><S><I><S><S><N><A><L>
Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.<BOP>
Q8NCE2
Q9H7L9
SDS3_HUMAN
Suppressor of defective silencing 3 protein homolog
Homo
<M><S><A><A><G><L><L><A><P><A><P><A><Q><A><G><A><P><P><A><P><E><Y><Y><P><E><E><D><E><E><L><E><S><A><E><D><D><E><R><S><C><R><G><R><E><S><D><E><D><T><E><D><A><S><E><T><D><L><A><K><H><D><E><E><D><Y><V><E><M><K><E><Q><M><Y><Q><D><K><L><A><S><L><K><R><Q><L><Q><Q><L><Q><E><G><T><L><Q><E><Y><Q><K><R><M><K><K><L><D><Q><Q><Y><K><E><R><I><R><N><A><E><L><F><L><Q><L><E><T><E><Q><V><E><R><N><Y><I><K><E><K><K><A><A><V><K><E><F><E><D><K><K><V><E><L><K><E><N><L><I><A><E><L><E><E><K><K><K><M><I><E><N><E><K><L><T><M><E><L><T><G><D><S><M><E><V><K><P><I><M><T><R><K><L><R><R><R><P><N><D><P><V><P><I><P><D><K><R><R><K><P><A><P><A><Q><L><N><Y><L><L><T><D><E><Q><I><M><E><D><L><R><T><L><N><K><L><K><S><P><K><R><P><A><S><P><S><S><P><E><H><L><P><A><T><P><A><E><S><P><A><Q><R><F><E><A><R><I><E><D><G><K><L><Y><Y><D><K><R><W><Y><H><K><S><Q><A><I><Y><L><E><S><K><D><N><Q><K><L><S><C><V><I><S><S><V><G><A><N><E><I><W><V><R><K><T><S><D><S><T><K><M><R><I><Y><L><G><Q><L><Q><R><G><L><F><V><I><R><R><R><S><A><A>
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.<BOP>
Q9H7L9
Q6UX07
DHR13_HUMAN
Short chain dehydrogenase/reductase family 7C member 5
Homo
<M><E><A><L><L><L><G><A><G><L><L><L><G><A><Y><V><L><V><Y><Y><N><L><V><K><A><P><P><C><G><G><M><G><N><L><R><G><R><T><A><V><V><T><G><A><N><S><G><I><G><K><M><T><A><L><E><L><A><R><R><G><A><R><V><V><L><A><C><R><S><Q><E><R><G><E><A><A><A><F><D><L><R><Q><E><S><G><N><N><E><V><I><F><M><A><L><D><L><A><S><L><A><S><V><R><A><F><A><T><A><F><L><S><S><E><P><R><L><D><I><L><I><H><N><A><G><I><S><S><C><G><R><T><R><E><A><F><N><L><L><L><R><V><N><H><I><G><P><F><L><L><T><H><L><L><L><P><C><L><K><A><C><A><P><S><R><V><V><V><V><A><S><A><A><H><C><R><G><R><L><D><F><K><R><L><D><R><P><V><V><G><W><R><Q><E><L><R><A><Y><A><D><T><K><L><A><N><V><L><F><A><R><E><L><A><N><Q><L><E><A><T><G><V><T><C><Y><A><A><H><P><G><P><V><N><S><E><L><F><L><R><H><V><P><G><W><L><R><P><L><L><R><P><L><A><W><L><V><L><R><A><P><R><G><G><A><Q><T><P><L><Y><C><A><L><Q><E><G><I><E><P><L><S><G><R><Y><F><A><N><C><H><V><E><E><V><P><P><A><A><R><D><D><R><A><A><H><R><L><W><E><A><S><K><R><L><A><G><L><G><P><G><E><D><A><E><P><D><E><D><P><Q><S><E><D><S><E><A><P><S><S><L><S><T><P><H><P><E><E><P><T><V><S><Q><P><Y><P><S><P><Q><S><S><P><D><L><S><K><M><T><H><R><I><Q><A><K><V><E><P><E><I><Q><L><S>
Putative oxidoreductase.<BOP>
Q6UX07
P56749
CLD12_HUMAN
Claudin-12
Homo
<M><G><C><R><D><V><H><A><A><T><V><L><S><F><L><C><G><I><A><S><V><A><G><L><F><A><G><T><L><L><P><N><W><R><K><L><R><L><I><T><F><N><R><N><E><K><N><L><T><V><Y><T><G><L><W><V><K><C><A><R><Y><D><G><S><S><D><C><L><M><Y><D><T><T><W><Y><S><S><V><D><Q><L><D><L><R><V><L><Q><F><A><L><P><L><S><M><L><I><A><M><G><A><L><L><L><C><L><I><G><M><C><N><T><A><F><R><S><S><V><P><N><I><K><L><A><K><C><L><V><N><S><A><G><C><H><L><V><A><G><L><L><F><F><L><A><G><T><V><S><L><S><P><S><I><W><V><I><F><Y><N><I><H><L><N><K><K><F><E><P><V><F><S><F><D><Y><A><V><Y><V><T><I><A><S><A><G><G><L><F><M><T><S><L><I><L><F><I><W><Y><C><T><C><K><S><L><P><S><P><F><W><Q><P><L><Y><S><H><P><P><S><M><H><T><Y><S><Q><P><Y><S><A><R><S><R><L><S><A><I><E><I><D><I><P><V><V><S><H><T><T>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
P56749
P26368
U2AF2_HUMAN
U2 snRNP auxiliary factor large subunit
Homo
<M><S><D><F><D><E><F><E><R><Q><L><N><E><N><K><Q><E><R><D><K><E><N><R><H><R><K><R><S><H><S><R><S><R><S><R><D><R><K><R><R><S><R><S><R><D><R><R><N><R><D><Q><R><S><A><S><R><D><R><R><R><R><S><K><P><L><T><R><G><A><K><E><E><H><G><G><L><I><R><S><P><R><H><E><K><K><K><K><V><R><K><Y><W><D><V><P><P><P><G><F><E><H><I><T><P><M><Q><Y><K><A><M><Q><A><A><G><Q><I><P><A><T><A><L><L><P><T><M><T><P><D><G><L><A><V><T><P><T><P><V><P><V><V><G><S><Q><M><T><R><Q><A><R><R><L><Y><V><G><N><I><P><F><G><I><T><E><E><A><M><M><D><F><F><N><A><Q><M><R><L><G><G><L><T><Q><A><P><G><N><P><V><L><A><V><Q><I><N><Q><D><K><N><F><A><F><L><E><F><R><S><V><D><E><T><T><Q><A><M><A><F><D><G><I><I><F><Q><G><Q><S><L><K><I><R><R><P><H><D><Y><Q><P><L><P><G><M><S><E><N><P><S><V><Y><V><P><G><V><V><S><T><V><V><P><D><S><A><H><K><L><F><I><G><G><L><P><N><Y><L><N><D><D><Q><V><K><E><L><L><T><S><F><G><P><L><K><A><F><N><L><V><K><D><S><A><T><G><L><S><K><G><Y><A><F><C><E><Y><V><D><I><N><V><T><D><Q><A><I><A><G><L><N><G><M><Q><L><G><D><K><K><L><L><V><Q><R><A><S><V><G><A><K><N><A><T><L><V><S><P><P><S><T><I><N><Q><T><P><V><T><L><Q><V><P><G><L><M><S><S><Q><V><Q><M><G><G><H><P><T><E><V><L><C><L><M><N><M><V><L><P><E><E><L><L><D><D><E><E><Y><E><E><I><V><E><D><V><R><D><E><C><S><K><Y><G><L><V><K><S><I><E><I><P><R><P><V><D><G><V><E><V><P><G><C><G><K><I><F><V><E><F><T><S><V><F><D><C><Q><K><A><M><Q><G><L><T><G><R><K><F><A><N><R><V><V><V><T><K><Y><C><D><P><D><S><Y><H><R><R><D><F><W>
Plays a role in pre-mRNA splicing and 3'-end processing . By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing . Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals .<BOP>
P26368
P56696
KCNQ4_HUMAN
Voltage-gated potassium channel subunit Kv7.4
Homo
<M><A><E><A><P><P><R><R><L><G><L><G><P><P><P><G><D><A><P><R><A><E><L><V><A><L><T><A><V><Q><S><E><Q><G><E><A><G><G><G><G><S><P><R><R><L><G><L><L><G><S><P><L><P><P><G><A><P><L><P><G><P><G><S><G><S><G><S><A><C><G><Q><R><S><S><A><A><H><K><R><Y><R><R><L><Q><N><W><V><Y><N><V><L><E><R><P><R><G><W><A><F><V><Y><H><V><F><I><F><L><L><V><F><S><C><L><V><L><S><V><L><S><T><I><Q><E><H><Q><E><L><A><N><E><C><L><L><I><L><E><F><V><M><I><V><V><F><G><L><E><Y><I><V><R><V><W><S><A><G><C><C><C><R><Y><R><G><W><Q><G><R><F><R><F><A><R><K><P><F><C><V><I><D><F><I><V><F><V><A><S><V><A><V><I><A><A><G><T><Q><G><N><I><F><A><T><S><A><L><R><S><M><R><F><L><Q><I><L><R><M><V><R><M><D><R><R><G><G><T><W><K><L><L><G><S><V><V><Y><A><H><S><K><E><L><I><T><A><W><Y><I><G><F><L><V><L><I><F><A><S><F><L><V><Y><L><A><E><K><D><A><N><S><D><F><S><S><Y><A><D><S><L><W><W><G><T><I><T><L><T><T><I><G><Y><G><D><K><T><P><H><T><W><L><G><R><V><L><A><A><G><F><A><L><L><G><I><S><F><F><A><L><P><A><G><I><L><G><S><G><F><A><L><K><V><Q><E><Q><H><R><Q><K><H><F><E><K><R><R><M><P><A><A><N><L><I><Q><A><A><W><R><L><Y><S><T><D><M><S><R><A><Y><L><T><A><T><W><Y><Y><Y><D><S><I><L><P><S><F><R><E><L><A><L><L><F><E><H><V><Q><R><A><R><N><G><G><L><R><P><L><E><V><R><R><A><P><V><P><D><G><A><P><S><R><Y><P><P><V><A><T><C><H><R><P><G><S><T><S><F><C><P><G><E><S><S><R><M><G><I><K><D><R><I><R><M><G><S><S><Q><R><R><T><G><P><S><K><Q><H><L><A><P><P><T><M><P><T><S><P><S><S><E><Q><V><G><E><A><T><S><P><T><K><V><Q><K><S><W><S><F><N><D><R><T><R><F><R><A><S><L><R><L><K><P><R><T><S><A><E><D><A><P><S><E><E><V><A><E><E><K><S><Y><Q><C><E><L><T><V><D><D><I><M><P><A><V><K><T><V><I><R><S><I><R><I><L><K><F><L><V><A><K><R><K><F><K><E><T><L><R><P><Y><D><V><K><D><V><I><E><Q><Y><S><A><G><H><L><D><M><L><G><R><I><K><S><L><Q><T><R><V><D><Q><I><V><G><R><G><P><G><D><R><K><A><R><E><K><G><D><K><G><P><S><D><A><E><V><V><D><E><I><S><M><M><G><R><V><V><K><V><E><K><Q><V><Q><S><I><E><H><K><L><D><L><L><L><G><F><Y><S><R><C><L><R><S><G><T><S><A><S><L><G><A><V><Q><V><P><L><F><D><P><D><I><T><S><D><Y><H><S><P><V><D><H><E><D><I><S><V><S><A><Q><T><L><S><I><S><R><S><V><S><T><N><M><D>
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.<BOP>
P56696
Q8N350
CBARP_HUMAN
Voltage-dependent calcium channel beta subunit-associated regulatory protein
Homo
<M><Q><P><T><A><T><M><A><T><A><A><T><T><T><T><T><T><T><A><T><V><A><L><T><T><S><W><D><N><A><T><G><R><P><T><A><E><P><D><P><I><L><D><N><Y><V><L><L><V><V><V><M><S><L><F><V><G><G><T><L><V><V><L><S><G><V><L><L><L><C><K><R><C><W><D><V><H><Q><R><L><N><R><A><M><E><E><A><E><K><T><T><T><T><Y><L><D><N><G><T><H><P><A><Q><D><P><D><F><R><G><E><D><P><E><C><Q><D><A><E><T><E><R><F><L><S><T><S><S><T><G><R><R><V><S><F><N><E><A><A><L><F><E><Q><S><R><K><T><Q><D><K><G><R><R><Y><T><L><T><E><G><D><F><H><H><L><K><N><A><R><L><T><H><L><H><L><P><P><L><K><I><V><T><I><H><E><C><D><S><G><E><A><S><S><A><T><T><P><H><P><A><T><S><P><K><A><T><L><A><I><F><Q><P><P><G><K><A><L><T><G><R><S><V><G><P><S><S><A><L><P><G><D><P><Y><N><S><A><A><G><A><T><D><F><A><E><I><S><P><S><A><S><S><D><S><G><E><G><T><S><L><D><A><G><T><R><S><T><K><A><G><G><P><G><A><A><A><G><P><G><E><A><G><P><G><S><G><A><G><T><V><L><Q><F><L><T><R><L><R><R><H><A><S><L><D><G><A><S><P><Y><F><K><V><K><K><W><K><L><E><P><S><Q><R><A><A><S><L><D><T><R><G><S><P><K><R><H><H><F><Q><R><Q><R><A><A><S><E><S><T><E><Q><E><E><G><D><A><P><Q><E><D><F><I><Q><Y><I><A><R><A><G><D><A><V><A><F><P><H><P><R><P><F><L><A><S><P><P><P><A><L><G><R><L><E><A><A><E><A><A><G><G><A><S><P><D><S><P><P><E><R><G><A><G><S><A><G><P><E><Q><Q><Q><P><P><L><E><P><D><A><E><R><D><A><G><P><E><Q><A><Q><T><S><Y><R><D><L><W><S><L><R><A><S><L><E><L><H><A><A><A><S><D><H><S><S><S><G><N><D><R><D><S><V><R><S><G><D><S><S><G><S><G><S><G><G><A><A><P><A><F><P><P><P><S><P><P><A><P><R><P><K><D><G><E><A><R><R><L><L><Q><M><D><S><G><Y><A><S><I><E><G><R><G><A><G><D><D><T><E><P><P><A><A><P><A><R><P><R><S><P><R><A><W><P><R><R><P><R><R><D><Y><S><I><D><E><K><T><D><A><L><F><H><E><F><L><R><H><D><P><H><F><D><D><T><P><A><A><A><R><H><R><A><R><A><H><P><H><A><R><K><Q><W><Q><R><G><R><Q><H><S><D><P><G><A><R><A><A><P><A><L><A><G><T><P><A><P><P><A><G><A><A><R><P><A><R><A><P><L><R><R><G><D><S><V><D><G><P><P><D><G><R><T><L><G><G><A><G><D><D><P><A><I><P><V><I><E><E><E><P><G><G><G><G><C><P><G><S><G><L><C><V><L><P><S><G><S><V><L><D><K><L><A><A><G><L><D><E><R><L><F><P><P><R><L><A><E><P><V><V><A><T><P><A><L><V><A><A><A><P><T><S><P><D><H><S><P><A>
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.<BOP>
Q8N350
O95221
OR5F1_HUMAN
Olfactory receptor OR11-167
Homo
<M><T><R><K><N><Y><T><S><L><T><E><F><V><L><L><G><L><A><D><T><L><E><L><Q><I><I><L><F><L><F><F><L><V><I><Y><T><L><T><V><L><G><N><L><G><M><I><L><L><I><R><I><D><S><Q><L><H><T><P><M><Y><F><F><L><A><N><L><S><F><V><D><V><C><N><S><T><T><I><T><P><K><M><L><A><D><L><L><S><E><K><K><T><I><S><F><A><G><C><F><L><Q><M><Y><F><F><I><S><L><A><T><T><E><C><I><L><F><G><L><M><A><Y><D><R><Y><A><A><I><C><R><P><L><L><Y><S><L><I><M><S><R><T><V><Y><L><K><M><A><A><G><A><F><A><A><G><L><L><N><F><M><V><N><T><S><H><V><S><S><L><S><F><C><D><S><N><V><I><H><H><F><F><C><D><S><P><P><L><F><K><L><S><C><S><D><T><I><L><K><E><S><I><S><S><I><L><A><G><V><N><I><V><G><T><L><L><V><I><L><S><S><Y><S><Y><V><L><F><S><I><F><S><M><H><S><G><E><G><R><H><R><A><F><S><T><C><A><S><H><L><T><A><I><I><L><F><Y><A><T><C><I><Y><T><Y><L><R><P><S><S><S><Y><S><L><N><Q><D><K><V><A><S><V><F><Y><T><V><V><I><P><M><L><N><P><L><I><Y><S><L><R><S><K><E><V><K><K><A><L><A><N><V><I><S><R><K><R><T><S><S><F><L>
Odorant receptor.<BOP>
O95221
Q9Y2N7
HIF3A_HUMAN
PAS domain-containing protein 7
Homo
<M><A><L><G><L><Q><R><A><R><S><T><T><E><L><R><K><E><K><S><R><D><A><A><R><S><R><R><S><Q><E><T><E><V><L><Y><Q><L><A><H><T><L><P><F><A><R><G><V><S><A><H><L><D><K><A><S><I><M><R><L><T><I><S><Y><L><R><M><H><R><L><C><A><A><G><E><W><N><Q><V><G><A><G><G><E><P><L><D><A><C><Y><L><K><A><L><E><G><F><V><M><V><L><T><A><E><G><D><M><A><Y><L><S><E><N><V><S><K><H><L><G><L><S><Q><L><E><L><I><G><H><S><I><F><D><F><I><H><P><C><D><Q><E><E><L><Q><D><A><L><T><P><Q><Q><T><L><S><R><R><K><V><E><A><P><T><E><R><C><F><S><L><R><M><K><S><T><L><T><S><R><G><R><T><L><N><L><K><A><A><T><W><K><V><L><N><C><S><G><H><M><R><A><Y><K><P><P><A><Q><T><S><P><A><G><S><P><D><S><E><P><P><L><Q><C><L><V><L><I><C><E><A><I><P><H><P><G><S><L><E><P><P><L><G><R><G><A><F><L><S><R><H><S><L><D><M><K><F><T><Y><C><D><D><R><I><A><E><V><A><G><Y><S><P><D><D><L><I><G><C><S><A><Y><E><Y><I><H><A><L><D><S><D><A><V><S><K><S><I><H><T><L><L><S><K><G><Q><A><V><T><G><Q><Y><R><F><L><A><R><S><G><G><Y><L><W><T><Q><T><Q><A><T><V><V><S><G><G><R><G><P><Q><S><E><S><I><V><C><V><H><F><L><I><S><Q><V><E><E><T><G><V><V><L><S><L><E><Q><T><E><Q><H><S><R><R><P><I><Q><R><G><A><P><S><Q><K><D><T><P><N><P><G><D><S><L><D><T><P><G><P><R><I><L><A><F><L><H><P><P><S><L><S><E><A><A><L><A><A><D><P><R><R><F><C><S><P><D><L><R><R><L><L><G><P><I><L><D><G><A><S><V><A><A><T><P><S><T><P><L><A><T><R><H><P><Q><S><P><L><S><A><D><L><P><D><E><L><P><V><G><T><E><N><V><H><R><L><F><T><S><G><K><D><T><E><A><V><E><T><D><L><D><I><A><Q><D><A><D><A><L><D><L><E><M><L><A><P><Y><I><S><M><D><D><D><F><Q><L><N><A><S><E><Q><L><P><R><A><Y><H><R><P><L><G><A><V><P><R><P><R><A><R><S><F><H><G><L><S><P><P><A><L><E><P><S><L><L><P><R><W><G><S><D><P><R><L><S><C><S><S><P><S><R><G><D><P><S><A><S><S><P><M><A><G><A><R><K><R><T><L><A><Q><S><S><E><D><E><D><E><G><V><E><L><L><G><V><R><P><P><K><R><S><P><S><P><E><H><E><N><F><L><L><F><P><L><S><L><S><F><L><L><T><G><G><P><A><P><G><S><L><Q><D><P><S><T><P><L><L><N><L><N><E><P><L><G><L><G><P><S><L><L><S><P><Y><S><D><E><D><T><T><Q><P><G><G><P><F><Q><P><R><A><G><S><A><Q><A><D>
Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.<BOP>
Q9Y2N7
P23258
TBG1_HUMAN
Gamma-tubulin complex component 1
Homo
<M><P><R><E><I><I><T><L><Q><L><G><Q><C><G><N><Q><I><G><F><E><F><W><K><Q><L><C><A><E><H><G><I><S><P><E><G><I><V><E><E><F><A><T><E><G><T><D><R><K><D><V><F><F><Y><Q><A><D><D><E><H><Y><I><P><R><A><V><L><L><D><L><E><P><R><V><I><H><S><I><L><N><S><P><Y><A><K><L><Y><N><P><E><N><I><Y><L><S><E><H><G><G><G><A><G><N><N><W><A><S><G><F><S><Q><G><E><K><I><H><E><D><I><F><D><I><I><D><R><E><A><D><G><S><D><S><L><E><G><F><V><L><C><H><S><I><A><G><G><T><G><S><G><L><G><S><Y><L><L><E><R><L><N><D><R><Y><P><K><K><L><V><Q><T><Y><S><V><F><P><N><Q><D><E><M><S><D><V><V><V><Q><P><Y><N><S><L><L><T><L><K><R><L><T><Q><N><A><D><C><V><V><V><L><D><N><T><A><L><N><R><I><A><T><D><R><L><H><I><Q><N><P><S><F><S><Q><I><N><Q><L><V><S><T><I><M><S><A><S><T><T><T><L><R><Y><P><G><Y><M><N><N><D><L><I><G><L><I><A><S><L><I><P><T><P><R><L><H><F><L><M><T><G><Y><T><P><L><T><T><D><Q><S><V><A><S><V><R><K><T><T><V><L><D><V><M><R><R><L><L><Q><P><K><N><V><M><V><S><T><G><R><D><R><Q><T><N><H><C><Y><I><A><I><L><N><I><I><Q><G><E><V><D><P><T><Q><V><H><K><S><L><Q><R><I><R><E><R><K><L><A><N><F><I><P><W><G><P><A><S><I><Q><V><A><L><S><R><K><S><P><Y><L><P><S><A><H><R><V><S><G><L><M><M><A><N><H><T><S><I><S><S><L><F><E><R><T><C><R><Q><Y><D><K><L><R><K><R><E><A><F><L><E><Q><F><R><K><E><D><M><F><K><D><N><F><D><E><M><D><T><S><R><E><I><V><Q><Q><L><I><D><E><Y><H><A><A><T><R><P><D><Y><I><S><W><G><T><Q><E><Q>
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.<BOP>
P23258
P83916
CBX1_HUMAN
p25beta
Homo
<M><G><K><K><Q><N><K><K><K><V><E><E><V><L><E><E><E><E><E><E><Y><V><V><E><K><V><L><D><R><R><V><V><K><G><K><V><E><Y><L><L><K><W><K><G><F><S><D><E><D><N><T><W><E><P><E><E><N><L><D><C><P><D><L><I><A><E><F><L><Q><S><Q><K><T><A><H><E><T><D><K><S><E><G><G><K><R><K><A><D><S><D><S><E><D><K><G><E><E><S><K><P><K><K><K><K><E><E><S><E><K><P><R><G><F><A><R><G><L><E><P><E><R><I><I><G><A><T><D><S><S><G><E><L><M><F><L><M><K><W><K><N><S><D><E><A><D><L><V><P><A><K><E><A><N><V><K><C><P><Q><V><V><I><S><F><Y><E><E><R><L><T><W><H><S><Y><P><S><E><D><D><D><K><K><D><D><K><N>
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.<BOP>
P83916
P20366
TKN1_HUMAN
C-terminal-flanking peptide
Homo
<M><K><I><L><V><A><L><A><V><F><F><L><V><S><T><Q><L><F><A><E><E><I><G><A><N><D><D><L><N><Y><W><S><D><W><Y><D><S><D><Q><I><K><E><E><L><P><E><P><F><E><H><L><L><Q><R><I><A><R><R><P><K><P><Q><Q><F><F><G><L><M><G><K><R><D><A><D><S><S><I><E><K><Q><V><A><L><L><K><A><L><Y><G><H><G><Q><I><S><H><K><R><H><K><T><D><S><F><V><G><L><M><G><K><R><A><L><N><S><V><A><Y><E><R><S><A><M><Q><N><Y><E><R><R><R>
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.<BOP>
P20366
P43121
MUC18_HUMAN
S-endo 1 endothelial-associated antigen
Homo
<M><G><L><P><R><L><V><C><A><F><L><L><A><A><C><C><C><C><P><R><V><A><G><V><P><G><E><A><E><Q><P><A><P><E><L><V><E><V><E><V><G><S><T><A><L><L><K><C><G><L><S><Q><S><Q><G><N><L><S><H><V><D><W><F><S><V><H><K><E><K><R><T><L><I><F><R><V><R><Q><G><Q><G><Q><S><E><P><G><E><Y><E><Q><R><L><S><L><Q><D><R><G><A><T><L><A><L><T><Q><V><T><P><Q><D><E><R><I><F><L><C><Q><G><K><R><P><R><S><Q><E><Y><R><I><Q><L><R><V><Y><K><A><P><E><E><P><N><I><Q><V><N><P><L><G><I><P><V><N><S><K><E><P><E><E><V><A><T><C><V><G><R><N><G><Y><P><I><P><Q><V><I><W><Y><K><N><G><R><P><L><K><E><E><K><N><R><V><H><I><Q><S><S><Q><T><V><E><S><S><G><L><Y><T><L><Q><S><I><L><K><A><Q><L><V><K><E><D><K><D><A><Q><F><Y><C><E><L><N><Y><R><L><P><S><G><N><H><M><K><E><S><R><E><V><T><V><P><V><F><Y><P><T><E><K><V><W><L><E><V><E><P><V><G><M><L><K><E><G><D><R><V><E><I><R><C><L><A><D><G><N><P><P><P><H><F><S><I><S><K><Q><N><P><S><T><R><E><A><E><E><E><T><T><N><D><N><G><V><L><V><L><E><P><A><R><K><E><H><S><G><R><Y><E><C><Q><G><L><D><L><D><T><M><I><S><L><L><S><E><P><Q><E><L><L><V><N><Y><V><S><D><V><R><V><S><P><A><A><P><E><R><Q><E><G><S><S><L><T><L><T><C><E><A><E><S><S><Q><D><L><E><F><Q><W><L><R><E><E><T><G><Q><V><L><E><R><G><P><V><L><Q><L><H><D><L><K><R><E><A><G><G><G><Y><R><C><V><A><S><V><P><S><I><P><G><L><N><R><T><Q><L><V><N><V><A><I><F><G><P><P><W><M><A><F><K><E><R><K><V><W><V><K><E><N><M><V><L><N><L><S><C><E><A><S><G><H><P><R><P><T><I><S><W><N><V><N><G><T><A><S><E><Q><D><Q><D><P><Q><R><V><L><S><T><L><N><V><L><V><T><P><E><L><L><E><T><G><V><E><C><T><A><S><N><D><L><G><K><N><T><S><I><L><F><L><E><L><V><N><L><T><T><L><T><P><D><S><N><T><T><T><G><L><S><T><S><T><A><S><P><H><T><R><A><N><S><T><S><T><E><R><K><L><P><E><P><E><S><R><G><V><V><I><V><A><V><I><V><C><I><L><V><L><A><V><L><G><A><V><L><Y><F><L><Y><K><K><G><K><L><P><C><R><R><S><G><K><Q><E><I><T><L><P><P><S><R><K><S><E><L><V><V><E><V><K><S><D><K><L><P><E><E><M><G><L><L><Q><G><S><S><G><D><K><R><A><P><G><D><Q><G><E><K><Y><I><D><L><R><H>
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.<BOP>
P43121
P78563
RED1_HUMAN
dsRNA adenosine deaminase
Homo
<M><D><I><E><D><E><E><N><M><S><S><S><S><T><D><V><K><E><N><R><N><L><D><N><V><S><P><K><D><G><S><T><P><G><P><G><E><G><S><Q><L><S><N><G><G><G><G><G><P><G><R><K><R><P><L><E><E><G><S><N><G><H><S><K><Y><R><L><K><K><R><R><K><T><P><G><P><V><L><P><K><N><A><L><M><Q><L><N><E><I><K><P><G><L><Q><Y><T><L><L><S><Q><T><G><P><V><H><A><P><L><F><V><M><S><V><E><V><N><G><Q><V><F><E><G><S><G><P><T><K><K><K><A><K><L><H><A><A><E><K><A><L><R><S><F><V><Q><F><P><N><A><S><E><A><H><L><A><M><G><R><T><L><S><V><N><T><D><F><T><S><D><Q><A><D><F><P><D><T><L><F><N><G><F><E><T><P><D><K><A><E><P><P><F><Y><V><G><S><N><G><D><D><S><F><S><S><S><G><D><L><S><L><S><A><S><P><V><P><A><S><L><A><Q><P><P><L><P><V><L><P><P><F><P><P><P><S><G><K><N><P><V><M><I><L><N><E><L><R><P><G><L><K><Y><D><F><L><S><E><S><G><E><S><H><A><K><S><F><V><M><S><V><V><V><D><G><Q><F><F><E><G><S><G><R><N><K><K><L><A><K><A><R><A><A><Q><S><A><L><A><A><I><F><N><L><H><L><D><Q><T><P><S><R><Q><P><I><P><S><E><G><L><Q><L><H><L><P><Q><V><L><A><D><A><V><S><R><L><V><L><G><K><F><G><D><L><T><D><N><F><S><S><P><H><A><R><R><K><V><L><A><G><V><V><M><T><T><G><T><D><V><K><D><A><K><V><I><S><V><S><T><G><T><K><C><I><N><G><E><Y><M><S><D><R><G><L><A><L><N><D><C><H><A><E><I><I><S><R><R><S><L><L><R><F><L><Y><T><Q><L><E><L><Y><L><N><N><K><D><D><Q><K><R><S><I><F><Q><K><S><E><R><G><G><F><R><L><K><E><N><V><Q><F><H><L><Y><I><S><T><S><P><C><G><D><A><R><I><F><S><P><H><E><P><I><L><E><G><S><R><S><Y><T><Q><A><G><V><Q><W><C><N><H><G><S><L><Q><P><R><P><P><G><L><L><S><D><P><S><T><S><T><F><Q><G><A><G><T><T><E><P><A><D><R><H><P><N><R><K><A><R><G><Q><L><R><T><K><I><E><S><G><E><G><T><I><P><V><R><S><N><A><S><I><Q><T><W><D><G><V><L><Q><G><E><R><L><L><T><M><S><C><S><D><K><I><A><R><W><N><V><V><G><I><Q><G><S><L><L><S><I><F><V><E><P><I><Y><F><S><S><I><I><L><G><S><L><Y><H><G><D><H><L><S><R><A><M><Y><Q><R><I><S><N><I><E><D><L><P><P><L><Y><T><L><N><K><P><L><L><S><G><I><S><N><A><E><A><R><Q><P><G><K><A><P><N><F><S><V><N><W><T><V><G><D><S><A><I><E><V><I><N><A><T><T><G><K><D><E><L><G><R><A><S><R><L><C><K><H><A><L><Y><C><R><W><M><R><V><H><G><K><V><P><S><H><L><L><R><S><K><I><T><K><P><N><V><Y><H><E><S><K><L><A><A><K><E><Y><Q><A><A><K><A><R><L><F><T><A><F><I><K><A><G><L><G><A><W><V><E><K><P><T><E><Q><D><Q><F><S><L><T><P>
Has a higher catalytic activity than isoform 1.<BOP>
P78563
Q9NRF8
PYRG2_HUMAN
UTP--ammonia ligase 2
Homo
<M><K><Y><I><L><V><T><G><G><V><I><S><G><I><G><K><G><I><I><A><S><S><I><G><T><I><L><K><S><C><G><L><R><V><T><A><I><K><I><D><P><Y><I><N><I><D><A><G><T><F><S><P><Y><E><H><G><E><V><F><V><L><N><D><G><G><E><V><D><L><D><L><G><N><Y><E><R><F><L><D><I><N><L><Y><K><D><N><N><I><T><T><G><K><I><Y><Q><H><V><I><N><K><E><R><R><G><D><Y><L><G><K><T><V><Q><V><V><P><H><I><T><D><A><V><Q><E><W><V><M><N><Q><A><K><V><P><V><D><G><N><K><E><E><P><Q><I><C><V><I><E><L><G><G><T><I><G><D><I><E><G><M><P><F><V><E><A><F><R><Q><F><Q><F><K><A><K><R><E><N><F><C><N><I><H><V><S><L><V><P><Q><L><S><A><T><G><E><Q><K><T><K><P><T><Q><N><S><V><R><A><L><R><G><L><G><L><S><P><D><L><I><V><C><R><S><S><T><P><I><E><M><A><V><K><E><K><I><S><M><F><C><H><V><N><P><E><Q><V><I><C><I><H><D><V><S><S><T><Y><R><V><P><V><L><L><E><E><Q><S><I><V><K><Y><F><K><E><R><L><H><L><P><I><G><D><S><A><S><N><L><L><F><K><W><R><N><M><A><D><R><Y><E><R><L><Q><K><I><C><S><I><A><L><V><G><K><Y><T><K><L><R><D><C><Y><A><S><V><F><K><A><L><E><H><S><A><L><A><I><N><H><K><L><N><L><M><Y><I><D><S><I><D><L><E><K><I><T><E><T><E><D><P><V><K><F><H><E><A><W><Q><K><L><C><K><A><D><G><I><L><V><P><G><G><F><G><I><R><G><T><L><G><K><L><Q><A><I><S><W><A><R><T><K><K><I><P><F><L><G><V><C><L><G><M><Q><L><A><V><I><E><F><A><R><N><C><L><N><L><K><D><A><D><S><T><E><F><R><P><N><A><P><V><P><L><V><I><D><M><P><E><H><N><P><G><N><L><G><G><T><M><R><L><G><I><R><R><T><V><F><K><T><E><N><S><I><L><R><K><L><Y><G><D><V><P><F><I><E><E><R><H><R><H><R><F><E><V><N><P><N><L><I><K><Q><F><E><Q><N><D><L><S><F><V><G><Q><D><V><D><G><D><R><M><E><I><I><E><L><A><N><H><P><Y><F><V><G><V><Q><F><H><P><E><F><S><S><R><P><M><K><P><S><P><P><Y><L><G><L><L><L><A><A><T><G><N><L><N><A><Y><L><Q><Q><G><C><K><L><S><S><S><D><R><Y><S><D><A><S><D><D><S><F><S><E><P><R><I><A><E><L><E><I><S>
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<BOP>
Q9NRF8
P48382
RFX5_HUMAN
Regulatory factor X 5
Homo
<M><A><E><D><E><P><D><A><K><S><P><K><T><G><G><R><A><P><P><G><G><A><E><A><G><E><P><T><T><L><L><Q><R><L><R><G><T><I><S><K><A><V><Q><N><K><V><E><G><I><L><Q><D><V><Q><K><F><S><D><N><D><K><L><Y><L><Y><L><Q><L><P><S><G><P><T><T><G><D><K><S><S><E><P><S><T><L><S><N><E><E><Y><M><Y><A><Y><R><W><I><R><N><H><L><E><E><H><T><D><T><C><L><P><K><Q><S><V><Y><D><A><Y><R><K><Y><C><E><S><L><A><C><C><R><P><L><S><T><A><N><F><G><K><I><I><R><E><I><F><P><D><I><K><A><R><R><L><G><G><R><G><Q><S><K><Y><C><Y><S><G><I><R><R><K><T><L><V><S><M><P><P><L><P><G><L><D><L><K><G><S><E><S><P><E><M><G><P><E><V><T><P><A><P><R><D><E><L><V><E><A><A><C><A><L><T><C><D><W><A><E><R><I><L><K><R><S><F><S><S><I><V><E><V><A><R><F><L><L><Q><Q><H><L><I><S><A><R><S><A><H><A><H><V><L><K><A><M><G><L><A><E><E><D><E><H><A><P><R><E><R><S><S><K><P><K><N><G><L><E><N><P><E><G><G><A><H><K><K><P><E><R><L><A><Q><P><P><K><D><L><E><A><R><T><G><A><G><P><L><A><R><G><E><R><K><K><S><V><V><E><S><S><A><P><G><A><N><N><L><Q><V><N><A><L><V><A><R><L><P><L><L><L><P><R><A><P><R><S><L><I><P><P><I><P><V><S><P><P><I><L><A><P><R><L><S><S><G><A><L><K><V><A><T><L><P><L><S><S><R><A><G><A><P><P><A><A><V><P><I><I><N><M><I><L><P><T><V><P><A><L><P><G><P><G><P><G><P><G><R><A><P><P><G><G><L><T><Q><P><R><G><T><E><N><R><E><V><G><I><G><G><D><Q><G><P><H><D><K><G><V><K><R><T><A><E><V><P><V><S><E><A><S><G><Q><A><P><P><A><K><A><A><K><Q><D><I><E><D><T><A><S><D><A><K><R><K><R><G><R><P><R><K><K><S><G><G><S><G><E><R><N><S><T><P><L><K><S><A><A><A><M><E><S><A><Q><S><S><R><L><P><W><E><T><W><G><S><G><G><E><G><N><S><A><G><G><A><E><R><P><G><P><M><G><E><A><E><K><G><A><V><L><A><Q><G><Q><G><D><G><T><V><S><K><G><G><R><G><P><G><S><Q><H><T><K><E><A><E><D><K><I><P><L><V><P><S><K><V><S><V><I><K><G><S><R><S><Q><K><E><A><F><P><L><A><K><G><E><V><D><T><A><P><Q><G><N><K><D><L><K><E><H><V><L><Q><S><S><L><S><Q><E><H><K><D><P><K><A><T><P><P>
Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters.<BOP>
P48382
P08670
VIME_HUMAN
Vimentin
Homo
<M><S><T><R><S><V><S><S><S><S><Y><R><R><M><F><G><G><P><G><T><A><S><R><P><S><S><S><R><S><Y><V><T><T><S><T><R><T><Y><S><L><G><S><A><L><R><P><S><T><S><R><S><L><Y><A><S><S><P><G><G><V><Y><A><T><R><S><S><A><V><R><L><R><S><S><V><P><G><V><R><L><L><Q><D><S><V><D><F><S><L><A><D><A><I><N><T><E><F><K><N><T><R><T><N><E><K><V><E><L><Q><E><L><N><D><R><F><A><N><Y><I><D><K><V><R><F><L><E><Q><Q><N><K><I><L><L><A><E><L><E><Q><L><K><G><Q><G><K><S><R><L><G><D><L><Y><E><E><E><M><R><E><L><R><R><Q><V><D><Q><L><T><N><D><K><A><R><V><E><V><E><R><D><N><L><A><E><D><I><M><R><L><R><E><K><L><Q><E><E><M><L><Q><R><E><E><A><E><N><T><L><Q><S><F><R><Q><D><V><D><N><A><S><L><A><R><L><D><L><E><R><K><V><E><S><L><Q><E><E><I><A><F><L><K><K><L><H><E><E><E><I><Q><E><L><Q><A><Q><I><Q><E><Q><H><V><Q><I><D><V><D><V><S><K><P><D><L><T><A><A><L><R><D><V><R><Q><Q><Y><E><S><V><A><A><K><N><L><Q><E><A><E><E><W><Y><K><S><K><F><A><D><L><S><E><A><A><N><R><N><N><D><A><L><R><Q><A><K><Q><E><S><T><E><Y><R><R><Q><V><Q><S><L><T><C><E><V><D><A><L><K><G><T><N><E><S><L><E><R><Q><M><R><E><M><E><E><N><F><A><V><E><A><A><N><Y><Q><D><T><I><G><R><L><Q><D><E><I><Q><N><M><K><E><E><M><A><R><H><L><R><E><Y><Q><D><L><L><N><V><K><M><A><L><D><I><E><I><A><T><Y><R><K><L><L><E><G><E><E><S><R><I><S><L><P><L><P><N><F><S><S><L><N><L><R><E><T><N><L><D><S><L><P><L><V><D><T><H><S><K><R><T><L><L><I><K><T><V><E><T><R><D><G><Q><V><I><N><E><T><S><Q><H><H><D><D><L><E>
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.<BOP>
P08670
P13805
TNNT1_HUMAN
Slow skeletal muscle troponin T
Homo
<M><S><D><T><E><E><Q><E><Y><E><E><E><Q><P><E><E><E><A><A><E><E><E><E><E><A><P><E><E><P><E><P><V><A><E><P><E><E><E><R><P><K><P><S><R><P><V><V><P><P><L><I><P><P><K><I><P><E><G><E><R><V><D><F><D><D><I><H><R><K><R><M><E><K><D><L><L><E><L><Q><T><L><I><D><V><H><F><E><Q><R><K><K><E><E><E><E><L><V><A><L><K><E><R><I><E><R><R><R><S><E><R><A><E><Q><Q><R><F><R><T><E><K><E><R><E><R><Q><A><K><L><A><E><E><K><M><R><K><E><E><E><E><A><K><K><R><A><E><D><D><A><K><K><K><K><V><L><S><N><M><G><A><H><F><G><G><Y><L><V><K><A><E><Q><K><R><G><K><R><Q><T><G><R><E><M><K><V><R><I><L><S><E><R><K><K><P><L><D><I><D><Y><M><G><E><E><Q><L><R><A><R><S><A><W><L><P><P><S><Q><P><S><C><P><A><R><E><K><A><Q><E><L><S><D><W><I><H><Q><L><E><S><E><K><F><D><L><M><A><K><L><K><Q><Q><K><Y><E><I><N><V><L><Y><N><R><I><S><H><A><Q><K><F><R><K><G><A><G><K><G><R><V><G><G><R><W><K>
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP>
P13805
P82970
HMGN5_HUMAN
Nucleosome-binding protein 1
Homo
<M><P><K><R><K><A><A><G><Q><G><D><M><R><Q><E><P><K><R><R><S><A><R><L><S><A><M><L><V><P><V><T><P><E><V><K><P><K><R><T><S><S><S><R><K><M><K><T><K><S><D><M><M><E><E><N><I><D><T><S><A><Q><A><V><A><E><T><K><Q><E><A><V><V><E><E><D><Y><N><E><N><A><K><N><G><E><A><K><I><T><E><A><P><A><S><E><K><E><I><V><E><V><K><E><E><N><I><E><D><A><T><E><K><G><G><E><K><K><E><A><V><A><A><E><V><K><N><E><E><E><D><Q><K><E><D><E><E><D><Q><N><E><E><K><G><E><A><G><K><E><D><K><D><E><K><G><E><E><D><G><K><E><D><K><N><G><N><E><K><G><E><D><A><K><E><K><E><D><G><K><K><G><E><D><G><K><G><N><G><E><D><G><K><E><K><G><E><D><E><K><E><E><E><D><R><K><E><T><G><D><G><K><E><N><E><D><G><K><E><K><G><D><K><K><E><G><K><D><V><K><V><K><E><D><E><K><E><R><E><D><G><K><E><D><E><G><G><N><E><E><E><A><G><K><E><K><E><D><L><K><E><E><E><E><G><K><E><E><D><E><I><K><E><D><D><G><K><K><E><E><P><Q><S><I><V>
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.<BOP>
P82970
Q9NPY3
C1QR1_HUMAN
Matrix-remodeling-associated protein 4
Homo
<M><A><T><S><M><G><L><L><L><L><L><L><L><L><L><T><Q><P><G><A><G><T><G><A><D><T><E><A><V><V><C><V><G><T><A><C><Y><T><A><H><S><G><K><L><S><A><A><E><A><Q><N><H><C><N><Q><N><G><G><N><L><A><T><V><K><S><K><E><E><A><Q><H><V><Q><R><V><L><A><Q><L><L><R><R><E><A><A><L><T><A><R><M><S><K><F><W><I><G><L><Q><R><E><K><G><K><C><L><D><P><S><L><P><L><K><G><F><S><W><V><G><G><G><E><D><T><P><Y><S><N><W><H><K><E><L><R><N><S><C><I><S><K><R><C><V><S><L><L><L><D><L><S><Q><P><L><L><P><S><R><L><P><K><W><S><E><G><P><C><G><S><P><G><S><P><G><S><N><I><E><G><F><V><C><K><F><S><F><K><G><M><C><R><P><L><A><L><G><G><P><G><Q><V><T><Y><T><T><P><F><Q><T><T><S><S><S><L><E><A><V><P><F><A><S><A><A><N><V><A><C><G><E><G><D><K><D><E><T><Q><S><H><Y><F><L><C><K><E><K><A><P><D><V><F><D><W><G><S><S><G><P><L><C><V><S><P><K><Y><G><C><N><F><N><N><G><G><C><H><Q><D><C><F><E><G><G><D><G><S><F><L><C><G><C><R><P><G><F><R><L><L><D><D><L><V><T><C><A><S><R><N><P><C><S><S><S><P><C><R><G><G><A><T><C><V><L><G><P><H><G><K><N><Y><T><C><R><C><P><Q><G><Y><Q><L><D><S><S><Q><L><D><C><V><D><V><D><E><C><Q><D><S><P><C><A><Q><E><C><V><N><T><P><G><G><F><R><C><E><C><W><V><G><Y><E><P><G><G><P><G><E><G><A><C><Q><D><V><D><E><C><A><L><G><R><S><P><C><A><Q><G><C><T><N><T><D><G><S><F><H><C><S><C><E><E><G><Y><V><L><A><G><E><D><G><T><Q><C><Q><D><V><D><E><C><V><G><P><G><G><P><L><C><D><S><L><C><F><N><T><Q><G><S><F><H><C><G><C><L><P><G><W><V><L><A><P><N><G><V><S><C><T><M><G><P><V><S><L><G><P><P><S><G><P><P><D><E><E><D><K><G><E><K><E><G><S><T><V><P><R><A><A><T><A><S><P><T><R><G><P><E><G><T><P><K><A><T><P><T><T><S><R><P><S><L><S><S><D><A><P><I><T><S><A><P><L><K><M><L><A><P><S><G><S><P><G><V><W><R><E><P><S><I><H><H><A><T><A><A><S><G><P><Q><E><P><A><G><G><D><S><S><V><A><T><Q><N><N><D><G><T><D><G><Q><K><L><L><L><F><Y><I><L><G><T><V><V><A><I><L><L><L><L><A><L><A><L><G><L><L><V><Y><R><K><R><R><A><K><R><E><E><K><K><E><K><K><P><Q><N><A><A><D><S><Y><S><W><V><P><E><R><A><E><S><R><A><M><E><N><Q><Y><S><P><T><P><G><T><D><C>
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.<BOP>
Q9NPY3
O15529
GPR42_HUMAN
G-protein coupled receptor 42
Homo
<M><D><T><G><P><D><Q><S><Y><F><S><G><N><H><W><F><V><F><S><V><Y><L><L><T><F><L><V><G><L><P><L><N><L><L><A><L><V><V><F><V><G><K><L><R><C><R><P><V><A><V><D><V><L><L><L><N><L><T><A><S><D><L><L><L><L><L><F><L><P><F><R><M><V><E><A><A><N><G><M><H><W><P><L><P><F><I><L><C><P><L><S><G><F><I><F><F><T><T><I><Y><L><T><A><L><F><L><A><A><V><S><I><E><R><F><L><S><V><A><H><P><L><W><Y><K><T><R><P><R><L><G><Q><A><G><L><V><S><V><A><C><W><L><L><A><S><A><H><C><S><V><V><Y><V><I><E><F><S><G><D><I><S><H><S><Q><G><T><N><G><T><C><Y><L><E><F><W><K><D><Q><L><A><I><L><L><P><V><R><L><E><M><A><V><V><L><F><V><V><P><L><I><I><T><S><Y><C><Y><S><R><L><V><W><I><L><G><R><G><G><S><H><R><R><Q><R><R><V><A><G><L><V><A><A><T><L><L><N><F><L><V><C><F><G><P><Y><N><V><S><H><V><V><G><Y><I><C><G><E><S><P><V><W><R><I><Y><V><T><L><L><S><T><L><N><S><C><V><D><P><F><V><Y><Y><F><S><S><S><G><F><Q><A><D><F><H><E><L><L><R><R><L><C><G><L><W><G><Q><W><Q><Q><E><S><S><M><E><L><K><E><Q><K><G><G><E><E><Q><R><A><D><R><P><A><E><R><K><T><S><E><H><S><Q><G><C><G><T><G><G><Q><V><A><C><A><E><N>
Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity.<BOP>
O15529
P34995
PE2R1_HUMAN
Prostanoid EP1 receptor
Homo
<M><S><P><C><G><P><L><N><L><S><L><A><G><E><A><T><T><C><A><A><P><W><V><P><N><T><S><A><V><P><P><S><G><A><S><P><A><L><P><I><F><S><M><T><L><G><A><V><S><N><L><L><A><L><A><L><L><A><Q><A><A><G><R><L><R><R><R><R><S><A><A><T><F><L><L><F><V><A><S><L><L><A><T><D><L><A><G><H><V><I><P><G><A><L><V><L><R><L><Y><T><A><G><R><A><P><A><G><G><A><C><H><F><L><G><G><C><M><V><F><F><G><L><C><P><L><L><L><G><C><G><M><A><V><E><R><C><V><G><V><T><R><P><L><L><H><A><A><R><V><S><V><A><R><A><R><L><A><L><A><A><V><A><A><V><A><L><A><V><A><L><L><P><L><A><R><V><G><R><Y><E><L><Q><Y><P><G><T><W><C><F><I><G><L><G><P><P><G><G><W><R><Q><A><L><L><A><G><L><F><A><S><L><G><L><V><A><L><L><A><A><L><V><C><N><T><L><S><G><L><A><L><L><R><A><R><W><R><R><R><S><R><R><P><P><P><A><S><G><P><D><S><R><R><R><W><G><A><H><G><P><R><S><A><S><A><S><S><A><S><S><I><A><S><A><S><T><F><F><G><G><S><R><S><S><G><S><A><R><R><A><R><A><H><D><V><E><M><V><G><Q><L><V><G><I><M><V><V><S><C><I><C><W><S><P><M><L><V><L><V><A><L><A><V><G><G><W><S><S><T><S><L><Q><R><P><L><F><L><A><V><R><L><A><S><W><N><Q><I><L><D><P><W><V><Y><I><L><L><R><Q><A><V><L><R><Q><L><L><R><L><L><P><P><R><A><G><A><K><G><G><P><A><G><L><G><L><T><P><S><A><W><E><A><S><S><L><R><S><S><R><H><S><G><L><S><H><F>
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.<BOP>
P34995
P08476
INHBA_HUMAN
Erythroid differentiation protein
Homo
<M><P><L><L><W><L><R><G><F><L><L><A><S><C><W><I><I><V><R><S><S><P><T><P><G><S><E><G><H><S><A><A><P><D><C><P><S><C><A><L><A><A><L><P><K><D><V><P><N><S><Q><P><E><M><V><E><A><V><K><K><H><I><L><N><M><L><H><L><K><K><R><P><D><V><T><Q><P><V><P><K><A><A><L><L><N><A><I><R><K><L><H><V><G><K><V><G><E><N><G><Y><V><E><I><E><D><D><I><G><R><R><A><E><M><N><E><L><M><E><Q><T><S><E><I><I><T><F><A><E><S><G><T><A><R><K><T><L><H><F><E><I><S><K><E><G><S><D><L><S><V><V><E><R><A><E><V><W><L><F><L><K><V><P><K><A><N><R><T><R><T><K><V><T><I><R><L><F><Q><Q><Q><K><H><P><Q><G><S><L><D><T><G><E><E><A><E><E><V><G><L><K><G><E><R><S><E><L><L><L><S><E><K><V><V><D><A><R><K><S><T><W><H><V><F><P><V><S><S><S><I><Q><R><L><L><D><Q><G><K><S><S><L><D><V><R><I><A><C><E><Q><C><Q><E><S><G><A><S><L><V><L><L><G><K><K><K><K><K><E><E><E><G><E><G><K><K><K><G><G><G><E><G><G><A><G><A><D><E><E><K><E><Q><S><H><R><P><F><L><M><L><Q><A><R><Q><S><E><D><H><P><H><R><R><R><R><R><G><L><E><C><D><G><K><V><N><I><C><C><K><K><Q><F><F><V><S><F><K><D><I><G><W><N><D><W><I><I><A><P><S><G><Y><H><A><N><Y><C><E><G><E><C><P><S><H><I><A><G><T><S><G><S><S><L><S><F><H><S><T><V><I><N><H><Y><R><M><R><G><H><S><P><F><A><N><L><K><S><C><C><V><P><T><K><L><R><P><M><S><M><L><Y><Y><D><D><G><Q><N><I><I><K><K><D><I><Q><N><M><I><V><E><E><C><G><C><S>
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.<BOP>
P08476
O43602
DCX_HUMAN
Lissencephalin-X
Homo
<M><E><L><D><F><G><H><F><D><E><R><D><K><T><S><R><N><M><R><G><S><R><M><N><G><L><P><S><P><T><H><S><A><H><C><S><F><Y><R><T><R><T><L><Q><A><L><S><N><E><K><K><A><K><K><V><R><F><Y><R><N><G><D><R><Y><F><K><G><I><V><Y><A><V><S><S><D><R><F><R><S><F><D><A><L><L><A><D><L><T><R><S><L><S><D><N><I><N><L><P><Q><G><V><R><Y><I><Y><T><I><D><G><S><R><K><I><G><S><M><D><E><L><E><E><G><E><S><Y><V><C><S><S><D><N><F><F><K><K><V><E><Y><T><K><N><V><N><P><N><W><S><V><N><V><K><T><S><A><N><M><K><A><P><Q><S><L><A><S><S><N><S><A><Q><A><R><E><N><K><D><F><V><R><P><K><L><V><T><I><I><R><S><G><V><K><P><R><K><A><V><R><V><L><L><N><K><K><T><A><H><S><F><E><Q><V><L><T><D><I><T><E><A><I><K><L><E><T><G><V><V><K><K><L><Y><T><L><D><G><K><Q><V><T><C><L><H><D><F><F><G><D><D><D><V><F><I><A><C><G><P><E><K><F><R><Y><A><Q><D><D><F><S><L><D><E><N><E><C><R><V><M><K><G><N><P><S><A><T><A><G><P><K><A><S><P><T><P><Q><K><T><S><A><K><S><P><G><P><M><R><R><S><K><S><P><A><D><S><G><N><D><Q><D><A><N><G><T><S><S><S><Q><L><S><T><P><K><S><K><Q><S><P><I><S><T><P><T><S><P><G><S><L><R><K><H><K><D><L><Y><L><P><L><S><L><D><D><S><D><S><L><G><D><S><M>
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.<BOP>
O43602
Q76B58
BRNP3_HUMAN
DBCCR1-like protein 1
Homo
<M><I><W><R><S><R><A><G><A><E><L><F><S><L><M><A><L><W><E><W><I><A><L><S><L><H><C><W><V><L><A><V><A><A><V><S><D><Q><H><A><T><S><P><F><D><W><L><L><S><D><K><G><P><F><H><R><S><Q><E><Y><T><D><F><V><D><R><S><R><Q><G><F><S><T><R><Y><K><I><Y><R><E><F><G><R><W><K><V><N><N><L><A><V><E><R><R><N><F><L><G><S><P><L><P><L><A><P><E><F><F><R><N><I><R><L><L><G><R><R><P><T><L><Q><Q><I><T><E><N><L><I><K><K><Y><G><T><H><F><L><L><S><A><T><L><G><G><E><E><S><L><T><I><F><V><D><K><R><K><L><S><K><R><A><E><G><S><D><S><T><T><N><S><S><S><V><T><L><E><T><L><H><Q><L><A><A><S><Y><F><I><D><R><D><S><T><L><R><R><L><H><H><I><Q><I><A><S><T><A><I><K><V><T><E><T><R><T><G><P><L><G><C><S><N><Y><D><N><L><D><S><V><S><S><V><L><V><Q><S><P><E><N><K><I><Q><L><Q><G><L><Q><V><L><L><P><D><Y><L><Q><E><R><F><V><Q><A><A><L><S><Y><I><A><C><N><S><E><G><E><F><I><C><K><E><N><D><C><W><C><H><C><G><P><K><F><P><E><C><N><C><P><S><M><D><I><Q><A><M><E><E><N><L><L><R><I><T><E><T><W><K><A><Y><N><S><D><F><E><E><S><D><E><F><K><L><F><M><K><R><L><P><M><N><Y><F><L><N><T><S><T><I><M><H><L><W><T><M><D><S><N><F><Q><R><R><Y><E><Q><L><E><N><S><M><K><Q><L><F><L><K><A><Q><K><I><V><H><K><L><F><S><L><S><K><R><C><H><K><Q><P><L><I><S><L><P><R><Q><R><T><S><T><Y><W><L><T><R><I><Q><S><F><L><Y><C><N><E><N><G><L><L><G><S><F><S><E><E><T><H><S><C><T><C><P><N><D><Q><V><V><C><T><A><F><L><P><C><T><V><G><D><A><S><A><C><L><T><C><A><P><D><N><R><T><R><C><G><T><C><N><T><G><Y><M><L><S><Q><G><L><C><K><P><E><V><A><E><S><T><D><H><Y><I><G><F><E><T><D><L><Q><D><L><E><M><K><Y><L><L><Q><K><T><D><R><R><I><E><V><H><A><I><F><I><S><N><D><M><R><L><N><S><W><F><D><P><S><W><R><K><R><M><L><L><T><L><K><S><N><K><Y><K><S><S><L><V><H><M><I><L><G><L><S><L><Q><I><C><L><T><K><N><S><T><L><E><P><V><L><A><V><Y><V><N><P><F><G><G><S><H><S><E><S><W><F><M><P><V><N><E><N><S><F><P><D><W><E><R><T><K><L><D><L><P><L><Q><C><Y><N><W><T><L><T><L><G><N><K><W><K><T><F><F><E><T><V><H><I><Y><L><R><S><R><I><K><S><N><G><P><N><G><N><E><S><I><Y><Y><E><P><L><E><F><I><D><P><S><R><N><L><G><Y><M><K><I><N><N><I><Q><V><F><G><Y><S><M><H><F><D><P><E><A><I><R><D><L><I><L><Q><L><D><Y><P><Y><T><Q><G><S><Q><D><S><A><L><L><Q><L><L><E><I><R><D><R><V><N><K><L><S><P><P><G><Q><R><R><L><D><L><F><S><C><L><L><R><H><R><L><K><L><S><T><S><E><V><V><R><I><Q><S><A><L><Q><A><F><N><A><K><L><P><N><T><M><D><Y><D><T><T><K><L><C><S>
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.<BOP>
Q76B58
P37287
PIGA_HUMAN
Phosphatidylinositol-glycan biosynthesis class A protein
Homo
<M><A><C><R><G><G><A><G><N><G><H><R><A><S><A><T><L><S><R><V><S><P><G><S><L><Y><T><C><R><T><R><T><H><N><I><C><M><V><S><D><F><F><Y><P><N><M><G><G><V><E><S><H><I><Y><Q><L><S><Q><C><L><I><E><R><G><H><K><V><I><I><V><T><H><A><Y><G><N><R><K><G><I><R><Y><L><T><S><G><L><K><V><Y><Y><L><P><L><K><V><M><Y><N><Q><S><T><A><T><T><L><F><H><S><L><P><L><L><R><Y><I><F><V><R><E><R><V><T><I><I><H><S><H><S><S><F><S><A><M><A><H><D><A><L><F><H><A><K><T><M><G><L><Q><T><V><F><T><D><H><S><L><F><G><F><A><D><V><S><S><V><L><T><N><K><L><L><T><V><S><L><C><D><T><N><H><I><I><C><V><S><Y><T><S><K><E><N><T><V><L><R><A><A><L><N><P><E><I><V><S><V><I><P><N><A><V><D><P><T><D><F><T><P><D><P><F><R><R><H><D><S><I><T><I><V><V><V><S><R><L><V><Y><R><K><G><I><D><L><L><S><G><I><I><P><E><L><C><Q><K><Y><P><D><L><N><F><I><I><G><G><E><G><P><K><R><I><I><L><E><E><V><R><E><R><Y><Q><L><H><D><R><V><R><L><L><G><A><L><E><H><K><D><V><R><N><V><L><V><Q><G><H><I><F><L><N><T><S><L><T><E><A><F><C><M><A><I><V><E><A><A><S><C><G><L><Q><V><V><S><T><R><V><G><G><I><P><E><V><L><P><E><N><L><I><I><L><C><E><P><S><V><K><S><L><C><E><G><L><E><K><A><I><F><Q><L><K><S><G><T><L><P><A><P><E><N><I><H><N><I><V><K><T><F><Y><T><W><R><N><V><A><E><R><T><E><K><V><Y><D><R><V><S><V><E><A><V><L><P><M><D><K><R><L><D><R><L><I><S><H><C><G><P><V><T><G><Y><I><F><A><L><L><A><V><F><N><F><L><F><L><I><F><L><R><W><M><T><P><D><S><I><I><D><V><A><I><D><A><T><G><P><R><G><A><W><T><N><N><Y><S><H><S><K><R><G><G><E><N><N><E><I><S><E><T><R>
Catalytic subunit of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP>
P37287
Q8NGC7
O11H6_HUMAN
Olfactory receptor OR14-35
Homo
<M><F><F><I><I><H><S><L><V><T><S><V><F><L><T><A><L><G><P><Q><N><R><T><M><H><F><V><T><E><F><V><L><L><G><F><H><G><Q><R><E><M><Q><S><C><F><F><S><F><I><L><V><L><Y><L><L><T><L><L><G><N><G><A><I><V><C><A><V><K><L><D><R><R><L><H><T><P><M><Y><I><L><L><G><N><F><A><F><L><E><I><W><Y><I><S><S><T><V><P><N><M><L><V><N><I><L><S><E><I><K><T><I><S><F><S><G><C><F><L><Q><F><Y><F><F><F><S><L><G><T><T><E><C><F><F><L><S><V><M><A><Y><D><R><Y><L><A><I><C><R><P><L><H><Y><P><S><I><M><T><G><K><F><C><I><I><L><V><C><V><C><W><V><G><G><F><L><C><Y><P><V><P><I><V><L><I><S><Q><L><P><F><C><G><P><N><I><I><D><H><L><V><C><D><P><G><P><L><F><A><L><A><C><I><S><A><P><S><T><E><L><I><C><Y><T><F><N><S><M><I><I><F><G><P><F><L><S><I><L><G><S><Y><T><L><V><I><R><A><V><L><C><I><P><S><G><A><G><R><T><K><A><F><S><T><C><G><S><H><L><M><V><V><S><L><F><Y><G><T><L><M><V><M><Y><V><S><P><T><S><G><N><P><A><G><M><Q><K><I><I><T><L><V><Y><T><A><M><T><P><F><L><N><P><L><I><Y><S><L><R><N><K><D><M><K><D><A><L><K><R><V><L><G><L><T><V><S><Q><N>
Odorant receptor.<BOP>
Q8NGC7
Q9NRG1
PRDC1_HUMAN
Phosphoribosyltransferase domain-containing protein 1
Homo
<M><A><G><S><S><E><E><A><P><D><Y><G><R><G><V><V><I><M><D><D><W><P><G><Y><D><L><N><L><F><T><Y><P><Q><H><Y><Y><G><D><L><E><Y><V><L><I><P><H><G><I><I><V><D><R><I><E><R><L><A><K><D><I><M><K><D><I><G><Y><S><D><I><M><V><L><C><V><L><K><G><G><Y><K><F><C><A><D><L><V><E><H><L><K><N><I><S><R><N><S><D><R><F><V><S><M><K><V><D><F><I><R><L><K><S><Y><R><N><D><Q><S><M><G><E><M><Q><I><I><G><G><D><D><L><S><T><L><A><G><K><N><V><L><I><V><E><D><V><V><G><T><G><R><T><M><K><A><L><L><S><N><I><E><K><Y><K><P><N><M><I><K><V><A><S><L><L><V><K><R><T><S><R><S><D><G><F><R><P><D><Y><A><G><F><E><I><P><N><L><F><V><V><G><Y><A><L><D><Y><N><E><Y><F><R><D><L><N><H><I><C><V><I><N><E><H><G><K><E><K><Y><R><V>
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.<BOP>
Q9NRG1
P46777
RL5_HUMAN
Large ribosomal subunit protein uL18
Homo
<M><G><F><V><K><V><V><K><N><K><A><Y><F><K><R><Y><Q><V><K><F><R><R><R><R><E><G><K><T><D><Y><Y><A><R><K><R><L><V><I><Q><D><K><N><K><Y><N><T><P><K><Y><R><M><I><V><R><V><T><N><R><D><I><I><C><Q><I><A><Y><A><R><I><E><G><D><M><I><V><C><A><A><Y><A><H><E><L><P><K><Y><G><V><K><V><G><L><T><N><Y><A><A><A><Y><C><T><G><L><L><L><A><R><R><L><L><N><R><F><G><M><D><K><I><Y><E><G><Q><V><E><V><T><G><D><E><Y><N><V><E><S><I><D><G><Q><P><G><A><F><T><C><Y><L><D><A><G><L><A><R><T><T><T><G><N><K><V><F><G><A><L><K><G><A><V><D><G><G><L><S><I><P><H><S><T><K><R><F><P><G><Y><D><S><E><S><K><E><F><N><A><E><V><H><R><K><H><I><M><G><Q><N><V><A><D><Y><M><R><Y><L><M><E><E><D><E><D><A><Y><K><K><Q><F><S><Q><Y><I><K><N><S><V><T><P><D><M><M><E><E><M><Y><K><K><A><H><A><A><I><R><E><N><P><V><Y><E><K><K><P><K><K><E><V><K><K><K><R><W><N><R><P><K><M><S><L><A><Q><K><K><D><R><V><A><Q><K><K><A><S><F><L><R><A><Q><E><R><A><A><E><S>
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs . It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed,
P46777
P13640
MT1G_HUMAN
Metallothionein-IG
Homo
<M><D><P><N><C><S><C><A><A><A><G><V><S><C><T><C><A><S><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><V><G><C><A><K><C><A><Q><G><C><I><C><K><G><A><S><E><K><C><S><C><C><A>
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP>
P13640
Q9UJW9
SRTD3_HUMAN
Replication protein-binding trans-activator
Homo
<M><V><G><G><L><K><R><K><H><S><D><L><E><E><E><E><E><R><W><E><W><S><P><A><G><L><Q><S><Y><Q><Q><A><L><L><R><I><S><L><D><K><V><Q><R><S><L><G><P><R><A><P><S><L><R><R><H><V><L><I><H><N><T><L><Q><Q><L><Q><A><A><L><R><L><A><P><A><P><A><L><P><P><E><P><L><F><L><G><E><E><D><F><S><L><S><A><T><I><G><S><I><L><R><E><L><D><T><S><M><D><G><T><E><P><P><Q><N><P><V><T><P><L><G><L><Q><N><E><V><P><P><Q><P><D><P><V><F><L><E><A><L><S><S><R><Y><L><G><D><S><G><L><D><D><F><F><L><D><I><D><T><S><A><V><E><K><E><P><A><R><A><P><P><E><P><P><H><N><L><F><C><A><P><G><S><W><E><W><N><E><L><D><H><I><M><E><I><I><L><G><S>
Strong transcriptional coactivator.<BOP>
Q9UJW9
Q02252
MMSA_HUMAN
Aldehyde dehydrogenase family 6 member A1
Homo
<M><A><A><L><L><A><A><A><A><V><R><A><R><I><L><Q><V><S><S><K><V><K><S><S><P><T><W><Y><S><A><S><S><F><S><S><S><V><P><T><V><K><L><F><I><G><G><K><F><V><E><S><K><S><D><K><W><I><D><I><H><N><P><A><T><N><E><V><I><G><R><V><P><Q><A><T><K><A><E><M><D><A><A><I><A><S><C><K><R><A><F><P><A><W><A><D><T><S><V><L><S><R><Q><Q><V><L><L><R><Y><Q><Q><L><I><K><E><N><L><K><E><I><A><K><L><I><T><L><E><Q><G><K><T><L><A><D><A><E><G><D><V><F><R><G><L><Q><V><V><E><H><A><C><S><V><T><S><L><M><M><G><E><T><M><P><S><I><T><K><D><M><D><L><Y><S><Y><R><L><P><L><G><V><C><A><G><I><A><P><F><N><F><P><A><M><I><P><L><W><M><F><P><M><A><M><V><C><G><N><T><F><L><M><K><P><S><E><R><V><P><G><A><T><M><L><L><A><K><L><L><Q><D><S><G><A><P><D><G><T><L><N><I><I><H><G><Q><H><E><A><V><N><F><I><C><D><H><P><D><I><K><A><I><S><F><V><G><S><N><K><A><G><E><Y><I><F><E><R><G><S><R><H><G><K><R><V><Q><A><N><M><G><A><K><N><H><G><V><V><M><P><D><A><N><K><E><N><T><L><N><Q><L><V><G><A><A><F><G><A><A><G><Q><R><C><M><A><L><S><T><A><V><L><V><G><E><A><K><K><W><L><P><E><L><V><E><H><A><K><N><L><R><V><N><A><G><D><Q><P><G><A><D><L><G><P><L><I><T><P><Q><A><K><E><R><V><C><N><L><I><D><S><G><T><K><E><G><A><S><I><L><L><D><G><R><K><I><K><V><K><G><Y><E><N><G><N><F><V><G><P><T><I><I><S><N><V><K><P><N><M><T><C><Y><K><E><E><I><F><G><P><V><L><V><V><L><E><T><E><T><L><D><E><A><I><Q><I><V><N><N><N><P><Y><G><N><G><T><A><I><F><T><T><N><G><A><T><A><R><K><Y><A><H><L><V><D><V><G><Q><V><G><V><N><V><P><I><P><V><P><L><P><M><F><S><F><T><G><S><R><S><S><F><R><G><D><T><N><F><Y><G><K><Q><G><I><Q><F><Y><T><Q><L><K><T><I><T><S><Q><W><K><E><E><D><A><T><L><S><S><P><A><V><V><M><P><T><M><G><R>
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.<BOP>
Q02252
Q9BUU2
MET22_HUMAN
Methyltransferase-like protein 22
Homo
<M><V><Q><L><A><P><A><A><A><M><D><E><V><T><F><R><S><D><T><V><L><S><D><V><H><L><Y><T><P><N><H><R><H><L><M><V><R><L><N><S><V><G><Q><P><V><F><L><S><Q><F><K><L><L><W><S><Q><D><S><W><T><D><S><G><A><K><G><G><S><H><R><D><V><H><T><K><E><P><P><S><A><E><T><G><S><T><G><S><P><P><G><S><G><H><G><N><E><G><F><S><L><Q><A><G><T><D><T><T><G><Q><E><V><A><E><A><Q><L><D><E><D><G><D><L><D><V><V><R><R><P><R><A><A><S><D><S><N><P><A><G><P><L><R><D><K><V><H><P><M><I><L><A><Q><E><E><D><D><V><L><G><E><E><A><Q><G><S><P><H><D><I><I><R><I><E><H><T><M><A><T><P><L><E><D><V><G><K><Q><V><W><R><G><A><L><L><L><A><D><Y><I><L><F><R><Q><D><L><F><R><G><C><T><A><L><E><L><G><A><G><T><G><L><A><S><I><I><A><A><T><M><A><R><T><V><Y><C><T><D><V><G><A><D><L><L><S><M><C><Q><R><N><I><A><L><N><S><H><L><A><A><T><G><G><G><I><V><R><V><K><E><L><D><W><L><K><D><D><L><C><T><D><P><K><V><P><F><S><W><S><Q><E><E><I><S><D><L><Y><D><H><T><T><I><L><F><A><A><E><V><F><Y><D><D><D><L><T><D><A><V><F><K><T><L><S><R><L><A><H><R><L><K><N><A><C><T><A><I><L><S><V><E><K><R><L><N><F><T><L><R><H><L><D><V><T><C><E><A><Y><D><H><F><R><S><C><L><H><A><L><E><Q><L><A><D><G><K><L><R><F><V><V><E><P><V><E><A><S><F><P><Q><L><L><V><Y><E><R><L><Q><Q><L><E><L><W><K><I><I><A><E><P><V><T>
Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro).<BOP>
Q9BUU2
Q05D32
CTSL2_HUMAN
CTD small phosphatase-like protein 2
Homo
<M><R><L><R><T><R><K><A><S><Q><Q><S><N><Q><I><Q><T><Q><R><T><A><R><A><K><R><K><Y><S><E><V><D><D><S><L><P><S><G><G><E><K><P><S><K><N><E><T><G><L><L><S><S><I><K><K><F><I><K><G><S><T><P><K><E><E><R><E><N><P><S><K><R><S><R><I><E><R><D><I><D><N><N><L><I><T><S><T><P><R><A><G><E><K><P><N><K><Q><I><S><R><V><R><R><K><S><Q><V><N><G><E><A><G><S><Y><E><M><T><N><Q><H><V><K><Q><N><G><K><L><E><D><N><P><S><S><G><S><P><P><R><T><T><L><L><G><T><I><F><S><P><V><F><N><F><F><S><P><A><N><K><N><G><T><S><G><S><D><S><P><G><Q><A><V><E><A><E><E><I><V><K><Q><L><D><M><E><Q><V><D><E><I><T><T><S><T><T><T><S><T><N><G><A><A><Y><S><N><Q><A><V><Q><V><R><P><S><L><N><N><G><L><E><E><A><E><E><T><V><N><R><D><I><P><P><L><T><A><P><V><T><P><D><S><G><Y><S><S><A><H><A><E><A><T><Y><E><E><D><W><E><V><F><D><P><Y><Y><F><I><K><H><V><P><P><L><T><E><E><Q><L><N><R><K><P><A><L><P><L><K><T><R><S><T><P><E><F><S><L><V><L><D><L><D><E><T><L><V><H><C><S><L><N><E><L><E><D><A><A><L><T><F><P><V><L><F><Q><D><V><I><Y><Q><V><Y><V><R><L><R><P><F><F><R><E><F><L><E><R><M><S><Q><M><Y><E><I><I><L><F><T><A><S><K><K><V><Y><A><D><K><L><L><N><I><L><D><P><K><K><Q><L><V><R><H><R><L><F><R><E><H><C><V><C><V><Q><G><N><Y><I><K><D><L><N><I><L><G><R><D><L><S><K><T><I><I><I><D><N><S><P><Q><A><F><A><Y><Q><L><S><N><G><I><P><I><E><S><W><F><M><D><K><N><D><N><E><L><L><K><L><I><P><F><L><E><K><L><V><E><L><N><E><D><V><R><P><H><I><R><D><R><F><R><L><H><D><L><L><P><P><D>
Probable phosphatase.<BOP>
Q05D32
P47736
RPGP1_HUMAN
Rap1 GTPase-activating protein 1
Homo
<M><I><E><K><M><Q><G><S><R><M><D><E><Q><R><C><S><F><P><P><P><L><K><T><E><E><D><Y><I><P><Y><P><S><V><H><E><V><L><G><R><E><G><P><F><P><L><I><L><L><P><Q><F><G><G><Y><W><I><E><G><T><N><H><E><I><T><S><I><P><E><T><E><P><L><Q><S><P><T><T><K><V><K><L><E><C><N><P><T><A><R><I><Y><R><K><H><F><L><G><K><E><H><F><N><Y><Y><S><L><D><A><A><L><G><H><L><V><F><S><L><K><Y><D><V><I><G><D><Q><E><H><L><R><L><L><L><R><T><K><C><R><T><Y><H><D><V><I><P><I><S><C><L><T><E><F><P><N><V><V><Q><M><A><K><L><V><C><E><D><V><N><V><D><R><F><Y><P><V><L><Y><P><K><A><S><R><L><I><V><T><F><D><E><H><V><I><S><N><N><F><K><F><G><V><I><Y><Q><K><L><G><Q><T><S><E><E><E><L><F><S><T><N><E><E><S><P><A><F><V><E><F><L><E><F><L><G><Q><K><V><K><L><Q><D><F><K><G><F><R><G><G><L><D><V><T><H><G><Q><T><G><T><E><S><V><Y><C><N><F><R><N><K><E><I><M><F><H><V><S><T><K><L><P><Y><T><E><G><D><A><Q><Q><L><Q><R><K><R><H><I><G><N><D><I><V><A><V><V><F><Q><D><E><N><T><P><F><V><P><D><M><I><A><S><N><F><L><H><A><Y><V><V><V><Q><A><E><G><G><G><P><D><G><P><L><Y><K><V><S><V><T><A><R><D><D><V><P><F><F><G><P><P><L><P><D><P><A><V><F><R><K><G><P><E><F><Q><E><F><L><L><T><K><L><I><N><A><E><Y><A><C><Y><K><A><E><K><F><A><K><L><E><E><R><T><R><A><A><L><L><E><T><L><Y><E><E><L><H><I><H><S><Q><S><M><M><G><L><G><G><D><E><D><K><M><E><N><G><S><G><G><G><G><F><F><E><S><F><K><R><V><I><R><S><R><S><Q><S><M><D><A><M><G><L><S><N><K><K><P><N><T><V><S><T><S><H><S><G><S><F><A><P><N><N><P><D><L><A><K><A><A><G><I><S><L><I><V><P><G><K><S><P><T><R><K><K><S><G><P><F><G><S><R><R><S><S><A><I><G><I><E><N><I><Q><E><V><Q><E><K><R><E><S><P><P><A><G><Q><K><T><P><D><S><G><H><V><S><Q><E><P><K><S><E><N><S><S><T><Q><S><S><P><E><M><P><T><T><K><N><R><A><E><T><A><A><Q><R><A><E><A><L><K><D><F><S><R><S><S><S><S><A><S><S><F><A><S><V><V><E><E><T><E><G><V><D><G><E><D><T><G><L><E><S><V><S><S><S><G><T><P><H><K><R><D><S><F><I><Y><S><T><W><L><E><D><S><V><S><T><T><S><G><G><S><S><P><G><P><S><R><S><P><H><P><D><A><G><K><L><G><D><P><A><C><P><E><I><K><I><Q><L><E><A><S><E><Q><H><M><P><Q><L><G><C>
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.<BOP>
P47736
Q8IZE3
PACE1_HUMAN
SCY1-like protein 3
Homo
<M><G><S><E><N><S><A><L><K><S><Y><T><L><R><E><P><P><F><T><L><P><S><G><L><A><V><Y><P><A><V><L><Q><D><G><K><F><A><S><V><F><V><Y><K><R><E><N><E><D><K><V><N><K><A><A><K><H><L><K><T><L><R><H><P><C><L><L><R><F><L><S><C><T><V><E><A><D><G><I><H><L><V><T><E><R><V><Q><P><L><E><V><A><L><E><T><L><S><S><A><E><V><C><A><G><I><Y><D><I><L><L><A><L><I><F><L><H><D><R><G><H><L><T><H><N><N><V><C><L><S><S><V><F><V><S><E><D><G><H><W><K><L><G><G><M><E><T><V><C><K><V><S><Q><A><T><P><E><F><L><R><S><I><Q><S><I><R><D><P><A><S><I><P><P><E><E><M><S><P><E><F><T><T><L><P><E><C><H><G><H><A><R><D><A><F><S><F><G><T><L><V><E><S><L><L><T><I><L><N><E><Q><V><S><A><D><V><L><S><S><F><Q><Q><T><L><H><S><T><L><L><N><P><I><P><K><C><R><P><A><L><C><T><L><L><S><H><D><F><F><R><N><D><F><L><E><V><V><N><F><L><K><S><L><T><L><K><S><E><E><E><K><T><E><F><F><K><F><L><L><D><R><V><S><C><L><S><E><E><L><I><A><S><R><L><V><P><L><L><L><N><Q><L><V><F><A><E><P><V><A><V><K><S><F><L><P><Y><L><L><G><P><K><K><D><H><A><Q><G><E><T><P><C><L><L><S><P><A><L><F><Q><S><R><V><I><P><V><L><L><Q><L><F><E><V><H><E><E><H><V><R><M><V><L><L><S><H><I><E><A><Y><V><E><H><F><T><Q><E><Q><L><K><K><V><I><L><P><Q><V><L><L><G><L><R><D><T><S><D><S><I><V><A><I><T><L><H><S><L><A><V><L><V><S><L><L><G><P><E><V><V><V><G><G><E><R><T><K><I><F><K><R><T><A><P><S><F><T><K><N><T><D><L><S><L><E><D><S><P><M><C><V><V><C><S><H><H><S><Q><I><S><P><I><L><E><N><P><F><S><S><I><F><P><K><C><F><F><S><G><S><T><P><I><N><S><K><K><H><I><Q><R><D><Y><Y><N><T><L><L><Q><T><G><D><P><F><S><Q><P><I><K><F><P><I><N><G><L><S><D><V><K><N><T><S><E><D><S><E><N><F><P><S><S><S><K><K><S><E><E><W><P><D><W><S><E><P><E><E><P><E><N><Q><T><V><N><I><Q><I><W><P><R><E><P><C><D><D><V><K><S><Q><C><T><T><L><D><V><E><E><S><S><W><D><D><C><E><P><S><S><L><D><T><K><V><N><P><G><G><G><I><T><A><T><K><P><V><T><S><G><E><Q><K><P><I><P><A><L><L><S><L><T><E><E><S><M><P><W><K><S><S><L><P><Q><K><I><S><L><V><Q><R><G><D><D><A><D><Q><I><E><P><P><K><V><S><S><Q><E><R><P><L><K><V><P><S><E><L><G><L><G><E><E><F><T><I><Q><V><K><K><K><P><V><K><D><P><E><M><D><W><F><A><D><M><I><P><E><I><K><P><S><A><A><F><L><I><L><P><E><L><R><T><E><M><V><P><K><K><D><D><V><S><P><V><M><Q><F><S><S><K><F><A><A><A><E><I><T><E><G><E><A><E><G><W><E><E><E><G><E><L><N><W><E><D><N><N><W>
May play a role in regulating cell adhesion/migration complexes in migrating cells.<BOP>
Q8IZE3
Q8NGN6
O10G7_HUMAN
Olfactory receptor OR11-283
Homo
<M><S><N><A><T><L><L><T><A><F><I><L><T><G><L><P><H><A><P><G><L><D><A><P><L><F><G><I><F><L><V><V><Y><V><L><T><V><L><G><N><L><L><I><L><L><V><I><R><V><D><S><H><L><H><T><P><M><Y><Y><F><L><T><N><L><S><F><I><D><M><W><F><S><T><V><T><V><P><K><M><L><M><T><L><V><S><P><S><G><R><T><I><S><F><H><S><C><V><A><Q><L><Y><F><F><H><F><L><G><S><T><E><C><F><L><Y><T><V><M><S><Y><D><R><Y><L><A><I><S><Y><P><L><R><Y><T><N><M><M><T><G><R><S><C><A><L><L><A><T><G><T><W><L><S><G><S><L><H><S><A><V><Q><T><I><L><T><F><H><L><P><Y><C><G><P><N><Q><I><Q><H><Y><F><C><D><A><P><P><I><L><K><L><A><C><A><D><T><S><A><N><E><M><V><I><F><V><N><I><G><L><V><A><S><G><C><F><V><L><I><V><L><S><Y><V><S><I><V><C><S><I><L><R><I><R><T><S><E><G><R><H><R><A><F><Q><T><C><A><S><H><C><I><V><V><L><C><F><F><G><P><G><L><F><I><Y><L><R><P><G><S><R><D><A><L><H><G><V><V><A><V><F><Y><T><T><L><T><P><L><F><N><P><V><V><Y><T><L><R><N><K><E><V><K><K><A><L><L><K><L><K><N><G><S><V><F><A><Q><G><E>
Odorant receptor.<BOP>
Q8NGN6
Q92466
DDB2_HUMAN
UV-damaged DNA-binding protein 2
Homo
<M><A><P><K><K><R><P><E><T><Q><K><T><S><E><I><V><L><R><P><R><N><K><R><S><R><S><P><L><E><L><E><P><E><A><K><K><L><C><A><K><G><S><G><P><S><R><R><C><D><S><D><C><L><W><V><G><L><A><G><P><Q><I><L><P><P><C><R><S><I><V><R><T><L><H><Q><H><K><L><G><R><A><S><W><P><S><V><Q><Q><G><L><Q><Q><S><F><L><H><T><L><D><S><Y><R><I><L><Q><K><A><A><P><F><D><R><R><A><T><S><L><A><W><H><P><T><H><P><S><T><V><A><V><G><S><K><G><G><D><I><M><L><W><N><F><G><I><K><D><K><P><T><F><I><K><G><I><G><A><G><G><S><I><T><G><L><K><F><N><P><L><N><T><N><Q><F><Y><A><S><S><M><E><G><T><T><R><L><Q><D><F><K><G><N><I><L><R><V><F><A><S><S><D><T><I><N><I><W><F><C><S><L><D><V><S><A><S><S><R><M><V><V><T><G><D><N><V><G><N><V><I><L><L><N><M><D><G><K><E><L><W><N><L><R><M><H><K><K><K><V><T><H><V><A><L><N><P><C><C><D><W><F><L><A><T><A><S><V><D><Q><T><V><K><I><W><D><L><R><Q><V><R><G><K><A><S><F><L><Y><S><L><P><H><R><H><P><V><N><A><A><C><F><S><P><D><G><A><R><L><L><T><T><D><Q><K><S><E><I><R><V><Y><S><A><S><Q><W><D><C><P><L><G><L><I><P><H><P><H><R><H><F><Q><H><L><T><P><I><K><A><A><W><H><P><R><Y><N><L><I><V><V><G><R><Y><P><D><P><N><F><K><S><C><T><P><Y><E><L><R><T><I><D><V><F><D><G><N><S><G><K><M><M><C><Q><L><Y><D><P><E><S><S><G><I><S><S><L><N><E><F><N><P><M><G><D><T><L><A><S><A><M><G><Y><H><I><L><I><W><S><Q><E><E><A><R><T><R><K>
Inhibits UV-damaged DNA repair.<BOP>
Q92466
P11487
FGF3_HUMAN
Proto-oncogene Int-2
Homo
<M><G><L><I><W><L><L><L><L><S><L><L><E><P><G><W><P><A><A><G><P><G><A><R><L><R><R><D><A><G><G><R><G><G><V><Y><E><H><L><G><G><A><P><R><R><R><K><L><Y><C><A><T><K><Y><H><L><Q><L><H><P><S><G><R><V><N><G><S><L><E><N><S><A><Y><S><I><L><E><I><T><A><V><E><V><G><I><V><A><I><R><G><L><F><S><G><R><Y><L><A><M><N><K><R><G><R><L><Y><A><S><E><H><Y><S><A><E><C><E><F><V><E><R><I><H><E><L><G><Y><N><T><Y><A><S><R><L><Y><R><T><V><S><S><T><P><G><A><R><R><Q><P><S><A><E><R><L><W><Y><V><S><V><N><G><K><G><R><P><R><R><G><F><K><T><R><R><T><Q><K><S><S><L><F><L><P><R><V><L><D><H><R><D><H><E><M><V><R><Q><L><Q><S><G><L><P><R><P><P><G><K><G><V><Q><P><R><R><R><R><Q><K><Q><S><P><D><N><L><E><P><S><H><V><Q><A><S><R><L><G><S><Q><L><E><A><S><A><H>
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.<BOP>
P11487
P19087
GNAT2_HUMAN
Transducin alpha-2 chain
Homo
<M><G><S><G><A><S><A><E><D><K><E><L><A><K><R><S><K><E><L><E><K><K><L><Q><E><D><A><D><K><E><A><K><T><V><K><L><L><L><L><G><A><G><E><S><G><K><S><T><I><V><K><Q><M><K><I><I><H><Q><D><G><Y><S><P><E><E><C><L><E><F><K><A><I><I><Y><G><N><V><L><Q><S><I><L><A><I><I><R><A><M><T><T><L><G><I><D><Y><A><E><P><S><C><A><D><D><G><R><Q><L><N><N><L><A><D><S><I><E><E><G><T><M><P><P><E><L><V><E><V><I><R><R><L><W><K><D><G><G><V><Q><A><C><F><E><R><A><A><E><Y><Q><L><N><D><S><A><S><Y><Y><L><N><Q><L><E><R><I><T><D><P><E><Y><L><P><S><E><Q><D><V><L><R><S><R><V><K><T><T><G><I><I><E><T><K><F><S><V><K><D><L><N><F><R><M><F><D><V><G><G><Q><R><S><E><R><K><K><W><I><H><C><F><E><G><V><T><C><I><I><F><C><A><A><L><S><A><Y><D><M><V><L><V><E><D><D><E><V><N><R><M><H><E><S><L><H><L><F><N><S><I><C><N><H><K><F><F><A><A><T><S><I><V><L><F><L><N><K><K><D><L><F><E><E><K><I><K><K><V><H><L><S><I><C><F><P><E><Y><D><G><N><N><S><Y><D><D><A><G><N><Y><I><K><S><Q><F><L><D><L><N><M><R><K><D><V><K><E><I><Y><S><H><M><T><C><A><T><D><T><Q><N><V><K><F><V><F><D><A><V><T><D><I><I><I><K><E><N><L><K><D><C><G><L><F>
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.<BOP>
P19087
P36544
ACHA7_HUMAN
Neuronal acetylcholine receptor subunit alpha-7
Homo
<M><R><C><S><P><G><G><V><W><L><A><L><A><A><S><L><L><H><V><S><L><Q><G><E><F><Q><R><K><L><Y><K><E><L><V><K><N><Y><N><P><L><E><R><P><V><A><N><D><S><Q><P><L><T><V><Y><F><S><L><S><L><L><Q><I><M><D><V><D><E><K><N><Q><V><L><T><T><N><I><W><L><Q><M><S><W><T><D><H><Y><L><Q><W><N><V><S><E><Y><P><G><V><K><T><V><R><F><P><D><G><Q><I><W><K><P><D><I><L><L><Y><N><S><A><D><E><R><F><D><A><T><F><H><T><N><V><L><V><N><S><S><G><H><C><Q><Y><L><P><P><G><I><F><K><S><S><C><Y><I><D><V><R><W><F><P><F><D><V><Q><H><C><K><L><K><F><G><S><W><S><Y><G><G><W><S><L><D><L><Q><M><Q><E><A><D><I><S><G><Y><I><P><N><G><E><W><D><L><V><G><I><P><G><K><R><S><E><R><F><Y><E><C><C><K><E><P><Y><P><D><V><T><F><T><V><T><M><R><R><R><T><L><Y><Y><G><L><N><L><L><I><P><C><V><L><I><S><A><L><A><L><L><V><F><L><L><P><A><D><S><G><E><K><I><S><L><G><I><T><V><L><L><S><L><T><V><F><M><L><L><V><A><E><I><M><P><A><T><S><D><S><V><P><L><I><A><Q><Y><F><A><S><T><M><I><I><V><G><L><S><V><V><V><T><V><I><V><L><Q><Y><H><H><H><D><P><D><G><G><K><M><P><K><W><T><R><V><I><L><L><N><W><C><A><W><F><L><R><M><K><R><P><G><E><D><K><V><R><P><A><C><Q><H><K><Q><R><R><C><S><L><A><S><V><E><M><S><A><V><A><P><P><P><A><S><N><G><N><L><L><Y><I><G><F><R><G><L><D><G><V><H><C><V><P><T><P><D><S><G><V><V><C><G><R><M><A><C><S><P><T><H><D><E><H><L><L><H><G><G><Q><P><P><E><G><D><P><D><L><A><K><I><L><E><E><V><R><Y><I><A><N><R><F><R><C><Q><D><E><S><E><A><V><C><S><E><W><K><F><A><A><C><V><V><D><R><L><C><L><M><A><F><S><V><F><T><I><I><C><T><I><G><I><L><M><S><A><P><N><F><V><E><A><V><S><K><D><F><A>
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.<BOP>
P36544
P14207
FOLR2_HUMAN
Placental folate-binding protein
Homo
<M><V><W><K><W><M><P><L><L><L><L><L><V><C><V><A><T><M><C><S><A><Q><D><R><T><D><L><L><N><V><C><M><D><A><K><H><H><K><T><K><P><G><P><E><D><K><L><H><D><Q><C><S><P><W><K><K><N><A><C><C><T><A><S><T><S><Q><E><L><H><K><D><T><S><R><L><Y><N><F><N><W><D><H><C><G><K><M><E><P><A><C><K><R><H><F><I><Q><D><T><C><L><Y><E><C><S><P><N><L><G><P><W><I><Q><Q><V><N><Q><S><W><R><K><E><R><F><L><D><V><P><L><C><K><E><D><C><Q><R><W><W><E><D><C><H><T><S><H><T><C><K><S><N><W><H><R><G><W><D><W><T><S><G><V><N><K><C><P><A><G><A><L><C><R><T><F><E><S><Y><F><P><T><P><A><A><L><C><E><G><L><W><S><H><S><Y><K><V><S><N><Y><S><R><G><S><G><R><C><I><Q><M><W><F><D><S><A><Q><G><N><P><N><E><E><V><A><R><F><Y><A><A><A><M><H><V><N><A><G><E><M><L><H><G><T><G><G><L><L><L><S><L><A><L><M><L><Q><L><W><L><L><G>
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.<BOP>
P14207
Q9GZN4
BSSP4_HUMAN
Tryptase epsilon
Homo
<M><V><V><S><G><A><P><P><A><L><G><G><G><C><L><G><T><F><T><S><L><L><L><L><A><S><T><A><I><L><N><A><A><R><I><P><V><P><P><A><C><G><K><P><Q><Q><L><N><R><V><V><G><G><E><D><S><T><D><S><E><W><P><W><I><V><S><I><Q><K><N><G><T><H><H><C><A><G><S><L><L><T><S><R><W><V><I><T><A><A><H><C><F><K><D><N><L><N><K><P><Y><L><F><S><V><L><L><G><A><W><Q><L><G><N><P><G><S><R><S><Q><K><V><G><V><A><W><V><E><P><H><P><V><Y><S><W><K><E><G><A><C><A><D><I><A><L><V><R><L><E><R><S><I><Q><F><S><E><R><V><L><P><I><C><L><P><D><A><S><I><H><L><P><P><N><T><H><C><W><I><S><G><W><G><S><I><Q><D><G><V><P><L><P><H><P><Q><T><L><Q><K><L><K><V><P><I><I><D><S><E><V><C><S><H><L><Y><W><R><G><A><G><Q><G><P><I><T><E><D><M><L><C><A><G><Y><L><E><G><E><R><D><A><C><L><G><D><S><G><G><P><L><M><C><Q><V><D><G><A><W><L><L><A><G><I><I><S><W><G><E><G><C><A><E><R><N><R><P><G><V><Y><I><S><L><S><A><H><R><S><W><V><E><K><I><V><Q><G><V><Q><L><R><G><R><A><Q><G><G><G><A><L><R><A><P><S><Q><G><S><G><A><A><A><R><S>
Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.<BOP>
Q9GZN4
Q8N138
ORML3_HUMAN
ORM1-like protein 3
Homo
<M><N><V><G><T><A><H><S><E><V><N><P><N><T><R><V><M><N><S><R><G><I><W><L><S><Y><V><L><A><I><G><L><L><H><I><V><L><L><S><I><P><F><V><S><V><P><V><V><W><T><L><T><N><L><I><H><N><M><G><M><Y><I><F><L><H><T><V><K><G><T><P><F><E><T><P><D><Q><G><K><A><R><L><L><T><H><W><E><Q><M><D><Y><G><V><Q><F><T><A><S><R><K><F><L><T><I><T><P><I><V><L><Y><F><L><T><S><F><Y><T><K><Y><D><Q><I><H><F><V><L><N><T><V><S><L><M><S><V><L><I><P><K><L><P><Q><L><H><G><V><R><I><F><G><I><N><K><Y>
Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.<BOP>
Q8N138
O75475
PSIP1_HUMAN
Transcriptional coactivator p75/p52
Homo
<M><T><R><D><F><K><P><G><D><L><I><F><A><K><M><K><G><Y><P><H><W><P><A><R><V><D><E><V><P><D><G><A><V><K><P><P><T><N><K><L><P><I><F><F><F><G><T><H><E><T><A><F><L><G><P><K><D><I><F><P><Y><S><E><N><K><E><K><Y><G><K><P><N><K><R><K><G><F><N><E><G><L><W><E><I><D><N><N><P><K><V><K><F><S><S><Q><Q><A><A><T><K><Q><S><N><A><S><S><D><V><E><V><E><E><K><E><T><S><V><S><K><E><D><T><D><H><E><E><K><A><S><N><E><D><V><T><K><A><V><D><I><T><T><P><K><A><A><R><R><G><R><K><R><K><A><E><K><Q><V><E><T><E><E><A><G><V><V><T><T><A><T><A><S><V><N><L><K><V><S><P><K><R><G><R><P><A><A><T><E><V><K><I><P><K><P><R><G><R><P><K><M><V><K><Q><P><C><P><S><E><S><D><I><I><T><E><E><D><K><S><K><K><K><G><Q><E><E><K><Q><P><K><K><Q><P><K><K><D><E><E><G><Q><K><E><E><D><K><P><R><K><E><P><D><K><K><E><G><K><K><E><V><E><S><K><R><K><N><L><A><K><T><G><V><T><S><T><S><D><S><E><E><E><G><D><D><Q><E><G><E><K><K><R><K><G><G><R><N><F><Q><T><A><H><R><R><N><M><L><K><G><Q><H><E><K><E><A><A><D><R><K><R><K><Q><E><E><Q><M><E><T><E><Q><Q><N><K><D><E><G><K><K><P><E><V><K><K><V><E><K><K><R><E><T><S><M><D><S><R><L><Q><R><I><H><A><E><I><K><N><S><L><K><I><D><N><L><D><V><N><R><C><I><E><A><L><D><E><L><A><S><L><Q><V><T><M><Q><Q><A><Q><K><H><T><E><M><I><T><T><L><K><K><I><R><R><F><K><V><S><Q><V><I><M><E><K><S><T><M><L><Y><N><K><F><K><N><M><F><L><V><G><E><G><D><S><V><I><T><Q><V><L><N><K><S><L><A><E><Q><R><Q><H><E><E><A><N><K><T><K><D><Q><G><K><K><G><P><N><K><K><L><E><K><E><Q><T><G><S><K><T><L><N><G><G><S><D><A><Q><D><G><N><Q><P><Q><H><N><G><E><S><N><E><D><S><K><D><N><H><E><A><S><T><K><K><K><P><S><S><E><E><R><E><T><E><I><S><L><K><D><S><T><L><D><N>
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<BOP>
O75475
O75452
RDH16_HUMAN
Sterol/retinol dehydrogenase
Homo
<M><W><L><Y><L><A><V><F><V><G><L><Y><Y><L><L><H><W><Y><R><E><R><Q><V><L><S><H><L><R><D><K><Y><V><F><I><T><G><C><D><S><G><F><G><K><L><L><A><R><Q><L><D><A><R><G><L><R><V><L><A><A><C><L><T><E><K><G><A><E><Q><L><R><G><Q><T><S><D><R><L><E><T><V><T><L><D><V><T><K><T><E><S><V><A><A><A><A><Q><W><V><K><E><C><V><R><D><K><G><L><W><G><L><V><N><N><A><G><I><S><L><P><T><A><P><N><E><L><L><T><K><Q><D><F><V><T><I><L><D><V><N><L><L><G><V><I><D><V><T><L><S><L><L><P><L><V><R><R><A><R><G><R><V><V><N><V><S><S><V><M><G><R><V><S><L><F><G><G><G><Y><C><I><S><K><Y><G><V><E><A><F><S><D><S><L><R><R><E><L><S><Y><F><G><V><K><V><A><M><I><E><P><G><Y><F><K><T><A><V><T><S><K><E><R><F><L><K><S><F><L><E><I><W><D><R><S><S><P><E><V><K><E><A><Y><G><E><K><F><V><A><D><Y><K><K><S><A><E><Q><M><E><Q><K><C><T><Q><D><L><S><L><V><T><N><C><M><E><H><A><L><I><A><C><H><P><R><T><R><Y><S><A><G><W><D><A><K><L><L><Y><L><P><M><S><Y><M><P><T><F><L><V><D><A><I><M><Y><W><V><S><P><S><P><A><K><A><L>
Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes . Has higher activity towards CRBP-bound retinol than with free retinol . Oxidizes also 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction .<BOP>
O75452
Q86Y07
VRK2_HUMAN
Vaccinia-related kinase 2
Homo
<M><P><P><K><R><N><E><K><Y><K><L><P><I><P><F><P><E><G><K><V><L><D><D><M><E><G><N><Q><W><V><L><G><K><K><I><G><S><G><G><F><G><L><I><Y><L><A><F><P><T><N><K><P><E><K><D><A><R><H><V><V><K><V><E><Y><Q><E><N><G><P><L><F><S><E><L><K><F><Y><Q><R><V><A><K><K><D><C><I><K><K><W><I><E><R><K><Q><L><D><Y><L><G><I><P><L><F><Y><G><S><G><L><T><E><F><K><G><R><S><Y><R><F><M><V><M><E><R><L><G><I><D><L><Q><K><I><S><G><Q><N><G><T><F><K><K><S><T><V><L><Q><L><G><I><R><M><L><D><V><L><E><Y><I><H><E><N><E><Y><V><H><G><D><I><K><A><A><N><L><L><L><G><Y><K><N><P><D><Q><V><Y><L><A><D><Y><G><L><S><Y><R><Y><C><P><N><G><N><H><K><Q><Y><Q><E><N><P><R><K><G><H><N><G><T><I><E><F><T><S><L><D><A><H><K><G><V><A><L><S><R><R><S><D><V><E><I><L><G><Y><C><M><L><R><W><L><C><G><K><L><P><W><E><Q><N><L><K><D><P><V><A><V><Q><T><A><K><T><N><L><L><D><E><L><P><Q><S><V><L><K><W><A><P><S><G><S><S><C><C><E><I><A><Q><F><L><V><C><A><H><S><L><A><Y><D><E><K><P><N><Y><Q><A><L><K><K><I><L><N><P><H><G><I><P><L><G><P><L><D><F><S><T><K><G><Q><S><I><N><V><H><T><P><N><S><Q><K><V><D><S><Q><K><A><A><T><K><Q><V><N><K><A><H><N><R><L><I><E><K><K><V><H><S><E><R><S><A><E><S><C><A><T><W><K><V><Q><K><E><E><K><L><I><G><L><M><N><N><E><A><A><Q><E><S><T><R><R><R><Q><K><Y><Q><E><S><Q><E><P><L><N><E><V><N><S><F><P><Q><K><I><S><Y><T><Q><F><P><N><S><F><Y><E><P><H><Q><D><F><T><S><P><D><I><F><K><K><S><R><S><P><S><W><Y><K><Y><T><S><T><V><S><T><G><I><T><D><L><E><S><S><T><G><L><W><P><T><I><S><Q><F><T><L><S><E><E><T><N><A><D><V><Y><Y><Y><R><I><I><I><P><V><L><L><M><L><V><F><L><A><L><F><F><L>
Phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.<BOP>
Q86Y07
P43627
KI2L2_HUMAN
p58 natural killer cell receptor clone CL-43
Homo
<M><S><L><M><V><V><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><P><H><E><G><V><H><R><K><P><S><L><L><A><H><P><G><R><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><R><F><E><H><F><L><L><H><R><E><G><K><F><K><D><T><L><H><L><I><G><E><H><H><D><G><V><S><K><A><N><F><S><I><G><P><M><M><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><T><H><S><P><Y><Q><L><S><A><P><S><D><P><L><D><I><V><I><T><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><L><A><G><E><S><V><T><L><S><C><S><S><R><S><S><Y><D><M><Y><H><L><S><R><E><G><E><A><H><E><C><R><F><S><A><G><P><K><V><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><R><C><F><G><S><F><R><D><S><P><Y><E><W><S><N><S><S><D><P><L><L><V><S><V><I><G><N><P><S><N><S><W><P><S><P><T><E><P><S><S><K><T><G><N><P><R><H><L><H><I><L><I><G><T><S><V><V><I><I><L><F><I><L><L><F><F><L><L><H><R><W><C><S><N><K><K><N><A><A><V><M><D><Q><E><S><A><G><N><R><T><A><N><S><E><D><S><D><E><Q><D><P><Q><E><V><T><Y><T><Q><L><N><H><C><V><F><T><Q><R><K><I><T><R><P><S><Q><R><P><K><T><P><P><T><D><I><I><V><Y><A><E><L><P><N><A><E><S><R><S><K><V><V><S><C><P>
Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.<BOP>
P43627
Q9P2E8
MARH4_HUMAN
RING-type E3 ubiquitin transferase MARCHF4
Homo
<M><L><M><P><L><C><G><L><L><W><W><W><W><C><C><C><S><G><W><Y><C><Y><G><L><C><A><P><A><P><Q><M><L><R><H><Q><G><L><L><K><C><R><C><R><M><L><F><N><D><L><K><V><F><L><L><R><R><P><P><Q><A><P><L><P><M><H><G><D><P><Q><P><P><G><L><A><A><N><N><T><L><P><A><L><G><A><G><G><W><A><G><W><R><G><P><R><E><V><V><G><R><E><P><P><P><V><P><P><P><P><P><L><P><P><S><S><V><E><D><D><W><G><G><P><A><T><E><P><P><A><S><L><L><S><S><A><S><S><D><D><F><C><K><E><K><T><E><D><R><Y><S><L><G><S><S><L><D><S><G><M><R><T><P><L><C><R><I><C><F><Q><G><P><E><Q><G><E><L><L><S><P><C><R><C><D><G><S><V><K><C><T><H><Q><P><C><L><I><K><W><I><S><E><R><G><C><W><S><C><E><L><C><Y><Y><K><Y><H><V><I><A><I><S><T><K><N><P><L><Q><W><Q><A><I><S><L><T><V><I><E><K><V><Q><V><A><A><A><I><L><G><S><L><F><L><I><A><S><I><S><W><L><I><W><S><T><F><S><P><S><A><R><W><Q><R><Q><D><L><L><F><Q><I><C><Y><G><M><Y><G><F><M><D><V><V><C><I><G><L><I><I><H><E><G><P><S><V><Y><R><I><F><K><R><W><Q><A><V><N><Q><Q><W><K><V><L><N><Y><D><K><T><K><D><L><E><D><Q><K><A><G><G><R><T><N><P><R><T><S><S><S><T><Q><A><N><I><P><S><S><E><E><E><T><A><G><T><P><A><P><E><Q><G><P><A><Q><A><A><G><H><P><S><G><P><L><S><H><H><H><C><A><Y><T><I><L><H><I><L><S><H><L><R><P><H><E><Q><R><S><P><P><G><S><S><R><E><L><V><M><R><V><T><T><V>
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.<BOP>
Q9P2E8
Q8IUH8
SPP2C_HUMAN
Intramembrane protease 5
Homo
<M><A><C><L><G><F><L><L><P><V><G><F><L><L><L><I><S><T><V><A><G><G><K><Y><G><V><A><H><V><V><S><E><N><W><S><K><D><Y><C><I><L><F><S><S><D><Y><I><T><L><P><R><D><L><H><H><A><P><L><L><P><L><Y><D><G><T><K><A><P><W><C><P><G><E><D><S><P><H><Q><A><Q><L><R><S><P><S><Q><R><P><L><R><Q><T><T><A><M><V><M><R><G><N><C><S><F><H><T><K><G><W><L><A><Q><G><Q><G><A><H><G><L><L><I><V><S><R><V><S><D><Q><Q><C><S><D><T><T><L><A><P><Q><D><P><R><Q><P><L><A><D><L><T><I><P><V><A><M><L><H><Y><A><D><M><L><D><I><L><S><H><T><R><G><E><A><V><V><R><V><A><M><Y><A><P><P><E><P><I><I><D><Y><N><M><L><V><I><F><I><L><A><V><G><T><V><A><A><G><G><Y><W><A><G><L><T><E><A><N><R><L><Q><R><R><R><A><R><R><G><G><G><S><G><G><H><H><Q><L><Q><E><A><A><A><A><E><G><A><Q><K><E><D><N><E><D><I><P><V><D><F><T><P><A><M><T><G><V><V><V><T><L><S><C><S><L><M><L><L><L><Y><F><F><Y><D><H><F><V><Y><V><T><I><G><I><F><G><L><G><A><G><I><G><L><Y><S><C><L><S><P><L><V><C><R><L><S><L><R><Q><Y><Q><R><P><P><H><S><L><W><A><S><L><P><L><P><L><L><L><L><A><S><L><C><A><T><V><I><I><F><W><V><A><Y><R><N><E><D><R><W><A><W><L><L><Q><D><T><L><G><I><S><Y><C><L><F><V><L><H><R><V><R><L><P><T><L><K><N><C><S><S><F><L><L><A><L><L><A><F><D><V><F><F><V><F><V><T><P><F><F><T><K><T><G><E><S><I><M><A><Q><V><A><L><G><P><A><E><S><S><S><H><E><R><L><P><M><V><L><K><V><P><R><L><R><V><S><A><L><T><L><C><S><Q><P><F><S><I><L><G><F><G><D><I><V><V><P><G><F><L><V><A><Y><C><C><R><F><D><V><Q><V><C><S><R><Q><I><Y><F><V><A><C><T><V><A><Y><A><V><G><L><L><V><T><F><M><A><M><V><L><M><Q><M><G><Q><P><A><L><L><Y><L><V><S><S><T><L><L><T><S><L><A><V><A><A><C><R><Q><E><L><S><L><F><W><T><G><Q><G><R><A><K><M><C><G><L><G><C><A><P><S><A><G><S><R><Q><K><Q><E><G><A><A><D><A><H><T><A><S><T><L><E><R><G><T><S><R><G><A><G><D><L><D><S><N><P><G><E><D><T><T><E><I><V><T><I><S><E><N><E><A><T><N><P><E><D><R><S><D><S><S><E><G><W><S><D><A><H><L><D><P><N><E><L><P><F><I><P><P><G><A><S><E><E><L><M><P><L><M><P><M><A><M><L><I><P><L><M><P><L><M><P><P><P><S><E><L><G><H><V><H><A><Q><A><Q><A><H><E><T><G><L><P><W><A><G><L><H><K><R><K><G><L><K><V><R><K><S><M><S><T><Q><A><P><L>
Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.<BOP>
Q8IUH8
Q9NW81
DMAC2_HUMAN
ATP synthase subunit s-like protein
Homo
<M><A><A><P><W><A><S><L><R><L><V><A><P><M><W><N><G><R><I><R><G><I><H><R><L><G><A><A><V><A><P><E><G><N><Q><K><K><K><R><T><I><L><Q><F><L><T><N><Y><F><Y><D><V><E><A><L><R><D><Y><L><L><Q><R><E><M><Y><K><V><H><E><K><N><R><S><Y><T><W><L><E><K><Q><H><G><P><Y><G><A><G><A><F><F><I><L><K><Q><G><G><A><V><K><F><R><D><K><E><W><I><R><P><D><K><Y><G><H><F><S><Q><E><F><W><N><F><C><E><V><P><V><E><A><V><D><A><G><D><C><D><I><N><Y><E><G><L><D><N><L><L><R><L><K><E><L><Q><S><L><S><L><Q><R><C><C><H><V><D><D><W><C><L><S><R><L><Y><P><L><A><D><S><L><Q><E><L><S><L><A><G><C><P><R><I><S><E><R><G><L><A><C><L><H><H><L><Q><N><L><R><R><L><D><I><S><D><L><P><A><V><S><N><P><G><L><T><Q><I><L><V><E><E><M><L><P><N><C><E><V><V><G><V><D><W><A><E><G><L><K><S><G><P><E><E><Q><P><R><D><T><A><S><P><V><P><A>
Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.<BOP>
Q9NW81
Q8NI60
COQ8A_HUMAN
aarF domain-containing protein kinase 3
Homo
<M><A><A><I><L><G><D><T><I><M><V><A><K><G><L><V><K><L><T><Q><A><A><V><E><T><H><L><Q><H><L><G><I><G><G><E><L><I><M><A><A><R><A><L><Q><S><T><A><V><E><Q><I><G><M><F><L><G><K><V><Q><G><Q><D><K><H><E><E><Y><F><A><E><N><F><G><G><P><E><G><E><F><H><F><S><V><P><H><A><A><G><A><S><T><D><F><S><S><A><S><A><P><D><Q><S><A><P><P><S><L><G><H><A><H><S><E><G><P><A><P><A><Y><V><A><S><G><P><F><R><E><A><G><F><P><G><Q><A><S><S><P><L><G><R><A><N><G><R><L><F><A><N><P><R><D><S><F><S><A><M><G><F><Q><R><R><F><F><H><Q><D><Q><S><P><V><G><G><L><T><A><E><D><I><E><K><A><R><Q><A><K><A><R><P><E><N><K><Q><H><K><Q><T><L><S><E><H><A><R><E><R><K><V><P><V><T><R><I><G><R><L><A><N><F><G><G><L><A><V><G><L><G><F><G><A><L><A><E><V><A><K><K><S><L><R><S><E><D><P><S><G><K><K><A><V><L><G><S><S><P><F><L><S><E><A><N><A><E><R><I><V><R><T><L><C><K><V><R><G><A><A><L><K><L><G><Q><M><L><S><I><Q><D><D><A><F><I><N><P><H><L><A><K><I><F><E><R><V><R><Q><S><A><D><F><M><P><L><K><Q><M><M><K><T><L><N><N><D><L><G><P><N><W><R><D><K><L><E><Y><F><E><E><R><P><F><A><A><A><S><I><G><Q><V><H><L><A><R><M><K><G><G><R><E><V><A><M><K><I><Q><Y><P><G><V><A><Q><S><I><N><S><D><V><N><N><L><M><A><V><L><N><M><S><N><M><L><P><E><G><L><F><P><E><H><L><I><D><V><L><R><R><E><L><A><L><E><C><D><Y><Q><R><E><A><A><C><A><R><K><F><R><D><L><L><K><G><H><P><F><F><Y><V><P><E><I><V><D><E><L><C><S><P><H><V><L><T><T><E><L><V><S><G><F><P><L><D><Q><A><E><G><L><S><Q><E><I><R><N><E><I><C><Y><N><I><L><V><L><C><L><R><E><L><F><E><F><H><F><M><Q><T><D><P><N><W><S><N><F><F><Y><D><P><Q><Q><H><K><V><A><L><L><D><F><G><A><T><R><E><Y><D><R><S><F><T><D><L><Y><I><Q><I><I><R><A><A><A><D><R><D><R><E><T><V><R><A><K><S><I><E><M><K><F><L><T><G><Y><E><V><K><V><M><E><D><A><H><L><D><A><I><L><I><L><G><E><A><F><A><S><D><E><P><F><D><F><G><T><Q><S><T><T><E><K><I><H><N><L><I><P><V><M><L><R><H><R><L><V><P><P><P><E><E><T><Y><S><L><H><R><K><M><G><G><S><F><L><I><C><S><K><L><K><A><R><F><P><C><K><A><M><F><E><E><A><Y><S><N><Y><C><K><R><Q><A><Q><Q>
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration . Its substrate specificity is unclear: does not show any protein kinase activity . Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates . Shows an unusual selectivity for binding ADP over ATP .<BOP>
Q8NI60
Q99594
TEAD3_HUMAN
TEA domain family member 3
Homo
<M><A><S><N><S><W><N><A><S><S><S><P><G><E><A><R><E><D><G><P><E><G><L><D><K><G><L><D><N><D><A><E><G><V><W><S><P><D><I><E><Q><S><F><Q><E><A><L><A><I><Y><P><P><C><G><R><R><K><I><I><L><S><D><E><G><K><M><Y><G><R><N><E><L><I><A><R><Y><I><K><L><R><T><G><K><T><R><T><R><K><Q><V><S><S><H><I><Q><V><L><A><R><K><K><V><R><E><Y><Q><V><G><I><K><A><M><N><L><D><Q><V><S><K><D><K><A><L><Q><S><M><A><S><M><S><S><A><Q><I><V><S><A><S><V><L><Q><N><K><F><S><P><P><S><P><L><P><Q><A><V><F><S><T><S><S><R><F><W><S><S><P><P><L><L><G><Q><Q><P><G><P><S><Q><D><I><K><P><F><A><Q><P><A><Y><P><I><Q><P><P><L><P><P><T><L><S><S><Y><E><P><L><A><P><L><P><S><A><A><A><S><V><P><V><W><Q><D><R><T><I><A><S><S><R><L><R><L><L><E><Y><S><A><F><M><E><V><Q><R><D><P><D><T><Y><S><K><H><L><F><V><H><I><G><Q><T><N><P><A><F><S><D><P><P><L><E><A><V><D><V><R><Q><I><Y><D><K><F><P><E><K><K><G><G><L><K><E><L><Y><E><K><G><P><P><N><A><F><F><L><V><K><F><W><A><D><L><N><S><T><I><Q><E><G><P><G><A><F><Y><G><V><S><S><Q><Y><S><S><A><D><S><M><T><I><S><V><S><T><K><V><C><S><F><G><K><Q><V><V><E><K><V><E><T><E><Y><A><R><L><E><N><G><R><F><V><Y><R><I><H><R><S><P><M><C><E><Y><M><I><N><F><I><H><K><L><K><H><L><P><E><K><Y><M><M><N><S><V><L><E><N><F><T><I><L><Q><V><V><T><S><R><D><S><Q><E><T><L><L><V><I><A><F><V><F><E><V><S><T><S><E><H><G><A><Q><H><H><V><Y><K><L><V><K><D>
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.<BOP>
Q99594
Q5SVS4
KMCP1_HUMAN
Solute carrier family 25 member 30
Homo
<M><S><A><L><N><W><K><P><F><V><Y><G><G><L><A><S><I><T><A><E><C><G><T><F><P><I><D><L><T><K><T><R><L><Q><I><Q><G><Q><T><N><D><A><K><F><K><E><I><R><Y><R><G><M><L><H><A><L><V><R><I><G><R><E><E><G><L><K><A><L><Y><S><G><I><A><P><A><M><L><R><Q><A><S><Y><G><T><I><K><I><G><T><Y><Q><S><L><K><R><L><F><I><E><R><P><E><D><E><T><L><P><I><N><V><I><C><G><I><L><S><G><V><I><S><S><T><I><A><N><P><T><D><V><L><K><I><R><M><Q><A><Q><S><N><T><I><Q><G><G><M><I><G><N><F><M><N><I><Y><Q><Q><E><G><T><R><G><L><W><K><G><V><S><L><T><A><Q><R><A><A><I><V><V><G><V><E><L><P><V><Y><D><I><T><K><K><H><L><I><L><S><G><L><M><G><D><T><V><Y><T><H><F><L><S><S><F><T><C><G><L><A><G><A><L><A><S><N><P><V><D><V><V><R><T><R><M><M><N><Q><R><V><L><R><D><G><R><C><S><G><Y><T><G><T><L><D><C><L><L><Q><T><W><K><N><E><G><F><F><A><L><Y><K><G><F><W><P><N><W><L><R><L><G><P><W><N><I><I><F><F><V><T><Y><E><Q><L><K><K><L><D><L>
Probable transporter.<BOP>
Q5SVS4
Q15796
SMAD2_HUMAN
SMAD family member 2
Homo
<M><S><S><I><L><P><F><T><P><P><V><V><K><R><L><L><G><W><K><K><S><A><G><G><S><G><G><A><G><G><G><E><Q><N><G><Q><E><E><K><W><C><E><K><A><V><K><S><L><V><K><K><L><K><K><T><G><R><L><D><E><L><E><K><A><I><T><T><Q><N><C><N><T><K><C><V><T><I><P><S><T><C><S><E><I><W><G><L><S><T><P><N><T><I><D><Q><W><D><T><T><G><L><Y><S><F><S><E><Q><T><R><S><L><D><G><R><L><Q><V><S><H><R><K><G><L><P><H><V><I><Y><C><R><L><W><R><W><P><D><L><H><S><H><H><E><L><K><A><I><E><N><C><E><Y><A><F><N><L><K><K><D><E><V><C><V><N><P><Y><H><Y><Q><R><V><E><T><P><V><L><P><P><V><L><V><P><R><H><T><E><I><L><T><E><L><P><P><L><D><D><Y><T><H><S><I><P><E><N><T><N><F><P><A><G><I><E><P><Q><S><N><Y><I><P><E><T><P><P><P><G><Y><I><S><E><D><G><E><T><S><D><Q><Q><L><N><Q><S><M><D><T><G><S><P><A><E><L><S><P><T><T><L><S><P><V><N><H><S><L><D><L><Q><P><V><T><Y><S><E><P><A><F><W><C><S><I><A><Y><Y><E><L><N><Q><R><V><G><E><T><F><H><A><S><Q><P><S><L><T><V><D><G><F><T><D><P><S><N><S><E><R><F><C><L><G><L><L><S><N><V><N><R><N><A><T><V><E><M><T><R><R><H><I><G><R><G><V><R><L><Y><Y><I><G><G><E><V><F><A><E><C><L><S><D><S><A><I><F><V><Q><S><P><N><C><N><Q><R><Y><G><W><H><P><A><T><V><C><K><I><P><P><G><C><N><L><K><I><F><N><N><Q><E><F><A><A><L><L><A><Q><S><V><N><Q><G><F><E><A><V><Y><Q><L><T><R><M><C><T><I><R><M><S><F><V><K><G><W><G><A><E><Y><R><R><Q><T><V><T><S><T><P><C><W><I><E><L><H><L><N><G><P><L><Q><W><L><D><K><V><L><T><Q><M><G><S><P><S><V><R><C><S><S><M><S>
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<BOP>
Q15796
O00187
MASP2_HUMAN
Mannan-binding lectin serine protease 2 B chain
Homo
<M><R><L><L><T><L><L><G><L><L><C><G><S><V><A><T><P><L><G><P><K><W><P><E><P><V><F><G><R><L><A><S><P><G><F><P><G><E><Y><A><N><D><Q><E><R><R><W><T><L><T><A><P><P><G><Y><R><L><R><L><Y><F><T><H><F><D><L><E><L><S><H><L><C><E><Y><D><F><V><K><L><S><S><G><A><K><V><L><A><T><L><C><G><Q><E><S><T><D><T><E><R><A><P><G><K><D><T><F><Y><S><L><G><S><S><L><D><I><T><F><R><S><D><Y><S><N><E><K><P><F><T><G><F><E><A><F><Y><A><A><E><D><I><D><E><C><Q><V><A><P><G><E><A><P><T><C><D><H><H><C><H><N><H><L><G><G><F><Y><C><S><C><R><A><G><Y><V><L><H><R><N><K><R><T><C><S><A><L><C><S><G><Q><V><F><T><Q><R><S><G><E><L><S><S><P><E><Y><P><R><P><Y><P><K><L><S><S><C><T><Y><S><I><S><L><E><E><G><F><S><V><I><L><D><F><V><E><S><F><D><V><E><T><H><P><E><T><L><C><P><Y><D><F><L><K><I><Q><T><D><R><E><E><H><G><P><F><C><G><K><T><L><P><H><R><I><E><T><K><S><N><T><V><T><I><T><F><V><T><D><E><S><G><D><H><T><G><W><K><I><H><Y><T><S><T><A><Q><P><C><P><Y><P><M><A><P><P><N><G><H><V><S><P><V><Q><A><K><Y><I><L><K><D><S><F><S><I><F><C><E><T><G><Y><E><L><L><Q><G><H><L><P><L><K><S><F><T><A><V><C><Q><K><D><G><S><W><D><R><P><M><P><A><C><S><I><V><D><C><G><P><P><D><D><L><P><S><G><R><V><E><Y><I><T><G><P><G><V><T><T><Y><K><A><V><I><Q><Y><S><C><E><E><T><F><Y><T><M><K><V><N><D><G><K><Y><V><C><E><A><D><G><F><W><T><S><S><K><G><E><K><S><L><P><V><C><E><P><V><C><G><L><S><A><R><T><T><G><G><R><I><Y><G><G><Q><K><A><K><P><G><D><F><P><W><Q><V><L><I><L><G><G><T><T><A><A><G><A><L><L><Y><D><N><W><V><L><T><A><A><H><A><V><Y><E><Q><K><H><D><A><S><A><L><D><I><R><M><G><T><L><K><R><L><S><P><H><Y><T><Q><A><W><S><E><A><V><F><I><H><E><G><Y><T><H><D><A><G><F><D><N><D><I><A><L><I><K><L><N><N><K><V><V><I><N><S><N><I><T><P><I><C><L><P><R><K><E><A><E><S><F><M><R><T><D><D><I><G><T><A><S><G><W><G><L><T><Q><R><G><F><L><A><R><N><L><M><Y><V><D><I><P><I><V><D><H><Q><K><C><T><A><A><Y><E><K><P><P><Y><P><R><G><S><V><T><A><N><M><L><C><A><G><L><E><S><G><G><K><D><S><C><R><G><D><S><G><G><A><L><V><F><L><D><S><E><T><E><R><W><F><V><G><G><I><V><S><W><G><S><M><N><C><G><E><A><G><Q><Y><G><V><Y><T><K><V><I><N><Y><I><P><W><I><E><N><I><I><S><D><F>
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<BOP>
O00187
O95251
KAT7_HUMAN
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Homo
<M><P><R><R><K><R><N><A><G><S><S><S><D><G><T><E><D><S><D><F><S><T><D><L><E><H><T><D><S><S><E><S><D><G><T><S><R><R><S><A><R><V><T><R><S><S><A><R><L><S><Q><S><S><Q><D><S><S><P><V><R><N><L><Q><S><F><G><T><E><E><P><A><Y><S><T><R><R><V><T><R><S><Q><Q><Q><P><T><P><V><T><P><K><K><Y><P><L><R><Q><T><R><S><S><G><S><E><T><E><Q><V><V><D><F><S><D><R><E><T><K><N><T><A><D><H><D><E><S><P><P><R><T><P><T><G><N><A><P><S><S><E><S><D><I><D><I><S><S><P><N><V><S><H><D><E><S><I><A><K><D><M><S><L><K><D><S><G><S><D><L><S><H><R><P><K><R><R><R><F><H><E><S><Y><N><F><N><M><K><C><P><T><P><G><C><N><S><L><G><H><L><T><G><K><H><E><R><H><F><S><I><S><G><C><P><L><Y><H><N><L><S><A><D><E><C><K><V><R><A><Q><S><R><D><K><Q><I><E><E><R><M><L><S><H><R><Q><D><D><N><N><R><H><A><T><R><H><Q><A><P><T><E><R><Q><L><R><Y><K><E><K><V><A><E><L><R><K><K><R><N><S><G><L><S><K><E><Q><K><E><K><Y><M><E><H><R><Q><T><Y><G><N><T><R><E><P><L><L><E><N><L><T><S><E><Y><D><L><D><L><F><R><R><A><Q><A><R><A><S><E><D><L><E><K><L><R><L><Q><G><Q><I><T><E><G><S><N><M><I><K><T><I><A><F><G><R><Y><E><L><D><T><W><Y><H><S><P><Y><P><E><E><Y><A><R><L><G><R><L><Y><M><C><E><F><C><L><K><Y><M><K><S><Q><T><I><L><R><R><H><M><A><K><C><V><W><K><H><P><P><G><D><E><I><Y><R><K><G><S><I><S><V><F><E><V><D><G><K><K><N><K><I><Y><C><Q><N><L><C><L><L><A><K><L><F><L><D><H><K><T><L><Y><Y><D><V><E><P><F><L><F><Y><V><M><T><E><A><D><N><T><G><C><H><L><I><G><Y><F><S><K><E><K><N><S><F><L><N><Y><N><V><S><C><I><L><T><M><P><Q><Y><M><R><Q><G><Y><G><K><M><L><I><D><F><S><Y><L><L><S><K><V><E><E><K><V><G><S><P><E><R><P><L><S><D><L><G><L><I><S><Y><R><S><Y><W><K><E><V><L><L><R><Y><L><H><N><F><Q><G><K><E><I><S><I><K><E><I><S><Q><E><T><A><V><N><P><V><D><I><V><S><T><L><Q><A><L><Q><M><L><K><Y><W><K><G><K><H><L><V><L><K><R><Q><D><L><I><D><E><W><I><A><K><E><A><K><R><S><N><S><N><K><T><M><D><P><S><C><L><K><W><T><P><P><K><G><T>
Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) . Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells .<BOP>
O95251
Q9NRY6
PLS3_HUMAN
Ca(2+)-dependent phospholipid scramblase 3
Homo
<M><A><G><Y><L><P><P><K><G><Y><A><P><S><P><P><P><P><Y><P><V><T><P><G><Y><P><E><P><A><L><H><P><G><P><G><Q><A><P><V><P><A><Q><V><P><A><P><A><P><G><F><A><L><F><P><S><P><G><P><V><A><L><G><S><A><A><P><F><L><P><L><P><G><V><P><S><G><L><E><F><L><V><Q><I><D><Q><I><L><I><H><Q><K><A><E><R><V><E><T><F><L><G><W><E><T><C><N><R><Y><E><L><R><S><G><A><G><Q><P><L><G><Q><A><A><E><E><S><N><C><C><A><R><L><C><C><G><A><R><R><P><L><R><V><R><L><A><D><P><G><D><R><E><V><L><R><L><L><R><P><L><H><C><G><C><S><C><C><P><C><G><L><Q><E><M><E><V><Q><A><P><P><G><T><T><I><G><H><V><L><Q><T><W><H><P><F><L><P><K><F><S><I><Q><D><A><D><R><Q><T><V><L><R><V><V><G><P><C><W><T><C><G><C><G><T><D><T><N><F><E><V><K><T><R><D><E><S><R><S><V><G><R><I><S><K><Q><W><G><G><L><V><R><E><A><L><T><D><A><D><D><F><G><L><Q><F><P><L><D><L><D><V><R><V><K><A><V><L><L><G><A><T><F><L><I><D><Y><M><F><F><E><K><R><G><G><A><G><P><S><A><V><T><S>
Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria . Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response . Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis . Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases . Regulates cardiolipin de novo biosynthesis and its resynthesis .<BOP>
Q9NRY6
O15296
LX15B_HUMAN
Linoleate 13-lipoxygenase 15-LOb
Homo
<M><A><E><F><R><V><R><V><S><T><G><E><A><F><G><A><G><T><W><D><K><V><S><V><S><I><V><G><T><R><G><E><S><P><P><L><P><L><D><N><L><G><K><E><F><T><A><G><A><E><E><D><F><Q><V><T><L><P><E><D><V><G><R><V><L><L><L><R><V><H><K><A><P><P><V><L><P><L><L><G><P><L><A><P><D><A><W><F><C><R><W><F><Q><L><T><P><P><R><G><G><H><L><L><F><P><C><Y><Q><W><L><E><G><A><G><T><L><V><L><Q><E><G><T><A><K><V><S><W><A><D><H><H><P><V><L><Q><Q><Q><R><Q><E><E><L><Q><A><R><Q><E><M><Y><Q><W><K><A><Y><N><P><G><W><P><H><C><L><D><E><K><T><V><E><D><L><E><L><N><I><K><Y><S><T><A><K><N><A><N><F><Y><L><Q><A><G><S><A><F><A><E><M><K><I><K><G><L><L><D><R><K><G><L><W><R><S><L><N><E><M><K><R><I><F><N><F><R><R><T><P><A><A><E><H><A><F><E><H><W><Q><E><D><A><F><F><A><S><Q><F><L><N><G><L><N><P><V><L><I><R><R><C><H><Y><L><P><K><N><F><P><V><T><D><A><M><V><A><S><V><L><G><P><G><T><S><L><Q><A><E><L><E><K><G><S><L><F><L><V><D><H><G><I><L><S><G><I><Q><T><N><V><I><N><G><K><P><Q><F><S><A><A><P><M><T><L><L><Y><Q><S><P><G><C><G><P><L><L><P><L><A><I><Q><L><S><Q><T><P><G><P><N><S><P><I><F><L><P><T><D><D><K><W><D><W><L><L><A><K><T><W><V><R><N><A><E><F><S><F><H><E><A><L><T><H><L><L><H><S><H><L><L><P><E><V><F><T><L><A><T><L><R><Q><L><P><H><C><H><P><L><F><K><L><L><I><P><H><T><R><Y><T><L><H><I><N><T><L><A><R><E><L><L><I><V><P><G><Q><V><V><D><R><S><T><G><I><G><I><E><G><F><S><E><L><I><Q><R><N><M><K><Q><L><N><Y><S><L><L><C><L><P><E><D><I><R><T><R><G><V><E><D><I><P><G><Y><Y><Y><R><D><D><G><M><Q><I><W><G><A><V><E><R><F><V><S><E><I><I><G><I><Y><Y><P><S><D><E><S><V><Q><D><D><R><E><L><Q><A><W><V><R><E><I><F><S><K><G><F><L><N><Q><E><S><S><G><I><P><S><S><L><E><T><R><E><A><L><V><Q><Y><V><T><M><V><I><F><T><C><S><A><K><H><A><A><V><S><A><G><Q><F><D><S><C><A><W><M><P><N><L><P><P><S><M><Q><L><P><P><P><T><S><K><G><L><A><T><C><E><G><F><I><A><T><L><P><P><V><N><A><T><C><D><V><I><L><A><L><W><L><L><S><K><E><P><G><D><Q><R><P><L><G><T><Y><P><D><E><H><F><T><E><E><A><P><R><R><S><I><A><T><F><Q><S><R><L><A><Q><I><S><R><G><I><Q><E><R><N><Q><G><L><V><L><P><Y><T><Y><L><D><P><P><L><I><E><N><S><V><S><I>
Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.<BOP>
O15296
O75955
FLOT1_HUMAN
Flotillin-1
Homo
<M><F><F><T><C><G><P><N><E><A><M><V><V><S><G><F><C><R><S><P><P><V><M><V><A><G><G><R><V><F><V><L><P><C><I><Q><Q><I><Q><R><I><S><L><N><T><L><T><L><N><V><K><S><E><K><V><Y><T><R><H><G><V><P><I><S><V><T><G><I><A><Q><V><K><I><Q><G><Q><N><K><E><M><L><A><A><A><C><Q><M><F><L><G><K><T><E><A><E><I><A><H><I><A><L><E><T><L><E><G><H><Q><R><A><I><M><A><H><M><T><V><E><E><I><Y><K><D><R><Q><K><F><S><E><Q><V><F><K><V><A><S><S><D><L><V><N><M><G><I><S><V><V><S><Y><T><L><K><D><I><H><D><D><Q><D><Y><L><H><S><L><G><K><A><R><T><A><Q><V><Q><K><D><A><R><I><G><E><A><E><A><K><R><D><A><G><I><R><E><A><K><A><K><Q><E><K><V><S><A><Q><Y><L><S><E><I><E><M><A><K><A><Q><R><D><Y><E><L><K><K><A><A><Y><D><I><E><V><N><T><R><R><A><Q><A><D><L><A><Y><Q><L><Q><V><A><K><T><K><Q><Q><I><E><E><Q><R><V><Q><V><Q><V><V><E><R><A><Q><Q><V><A><V><Q><E><Q><E><I><A><R><R><E><K><E><L><E><A><R><V><R><K><P><A><E><A><E><R><Y><K><L><E><R><L><A><E><A><E><K><S><Q><L><I><M><Q><A><E><A><E><A><A><S><V><R><M><R><G><E><A><E><A><F><A><I><G><A><R><A><R><A><E><A><E><Q><M><A><K><K><A><E><A><F><Q><L><Y><Q><E><A><A><Q><L><D><M><L><L><E><K><L><P><Q><V><A><E><E><I><S><G><P><L><T><S><A><N><K><I><T><L><V><S><S><G><S><G><T><M><G><A><A><K><V><T><G><E><V><L><D><I><L><T><R><L><P><E><S><V><E><R><L><T><G><V><S><I><S><Q><V><N><H><K><P><L><R><T><A>
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.<BOP>
O75955
Q8TF42
UBS3B_HUMAN
Tyrosine-protein phosphatase STS1/TULA2
Homo
<M><A><Q><Y><G><H><P><S><P><L><G><M><A><A><R><E><E><L><Y><S><K><V><T><P><R><R><N><R><Q><Q><R><P><G><T><I><K><H><G><S><A><L><D><V><L><L><S><M><G><F><P><R><A><R><A><Q><K><A><L><A><S><T><G><G><R><S><V><Q><A><A><C><D><W><L><F><S><H><V><G><D><P><F><L><D><D><P><L><P><R><E><Y><V><L><Y><L><R><P><T><G><P><L><A><Q><K><L><S><D><F><W><Q><Q><S><K><Q><I><C><G><K><N><K><A><H><N><I><F><P><H><I><T><L><C><Q><F><F><M><C><E><D><S><K><V><D><A><L><G><E><A><L><Q><T><T><V><S><R><W><K><C><K><F><S><A><P><L><P><L><E><L><Y><T><S><S><N><F><I><G><L><F><V><K><E><D><S><A><E><V><L><K><K><F><A><A><D><F><A><A><E><A><A><S><K><T><E><V><H><V><E><P><H><K><K><Q><L><H><V><T><L><A><Y><H><F><Q><A><S><H><L><P><T><L><E><K><L><A><Q><N><I><D><V><K><L><G><C><D><W><V><A><T><I><F><S><R><D><I><R><F><A><N><H><E><T><L><Q><V><I><Y><P><Y><T><P><Q><N><D><D><E><L><E><L><V><P><G><D><F><I><F><M><S><P><M><E><Q><T><S><T><S><E><G><W><I><Y><G><T><S><L><T><T><G><C><S><G><L><L><P><E><N><Y><I><T><K><A><D><E><C><S><T><W><I><F><H><G><S><Y><S><I><L><N><T><S><S><S><N><S><L><T><F><G><D><G><V><L><E><R><R><P><Y><E><D><Q><G><L><G><E><T><T><P><L><T><I><I><C><Q><P><M><Q><P><L><R><V><N><S><Q><P><G><P><Q><K><R><C><L><F><V><C><R><H><G><E><R><M><D><V><V><F><G><K><Y><W><L><S><Q><C><F><D><A><K><G><R><Y><I><R><T><N><L><N><M><P><H><S><L><P><Q><R><S><G><G><F><R><D><Y><E><K><D><A><P><I><T><V><F><G><C><M><Q><A><R><L><V><G><E><A><L><L><E><S><N><T><I><I><D><H><V><Y><C><S><P><S><L><R><C><V><Q><T><A><H><N><I><L><K><G><L><Q><Q><E><N><H><L><K><I><R><V><E><P><G><L><F><E><W><T><K><W><V><A><G><S><T><L><P><A><W><I><P><P><S><E><L><A><A><A><N><L><S><V><D><T><T><Y><R><P><H><I><P><I><S><K><L><V><V><S><E><S><Y><D><T><Y><I><S><R><S><F><Q><V><T><K><E><I><I><S><E><C><K><S><K><G><N><N><I><L><I><V><A><H><A><S><S><L><E><A><C><T><C><Q><L><Q><G><L><S><P><Q><N><S><K><D><F><V><Q><M><V><R><K><I><P><Y><L><G><F><C><S><C><E><E><L><G><E><T><G><I><W><Q><L><T><D><P><P><I><L><P><L><T><H><G><P><T><G><G><F><N><W><R><E><T><L><L><Q><E>
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.<BOP>
Q8TF42
Q9NPG8
ZDHC4_HUMAN
Zinc finger protein 374
Homo
<M><D><F><L><V><L><F><L><F><Y><L><A><S><V><L><M><G><L><V><L><I><C><V><C><S><K><T><H><S><L><K><G><L><A><R><G><G><A><Q><I><F><S><C><I><I><P><E><C><L><Q><R><A><V><H><G><L><L><H><Y><L><F><H><T><R><N><H><T><F><I><V><L><H><L><V><L><Q><G><M><V><Y><T><E><Y><T><W><E><V><F><G><Y><C><Q><E><L><E><L><S><L><H><Y><L><L><L><P><Y><L><L><L><G><V><N><L><F><F><F><T><L><T><C><G><T><N><P><G><I><I><T><K><A><N><E><L><L><F><L><H><V><Y><E><F><D><E><V><M><F><P><K><N><V><R><C><S><T><C><D><L><R><K><P><A><R><S><K><H><C><S><V><C><N><W><C><V><H><R><F><D><H><H><C><V><W><V><N><N><C><I><G><A><W><N><I><R><Y><F><L><I><Y><V><L><T><L><T><A><S><A><A><T><V><A><I><V><S><T><T><F><L><V><H><L><V><V><M><S><D><L><Y><Q><E><T><Y><I><D><D><L><G><H><L><H><V><M><D><T><V><F><L><I><Q><Y><L><F><L><T><F><P><R><I><V><F><M><L><G><F><V><V><V><L><S><F><L><L><G><G><Y><L><L><F><V><L><Y><L><A><A><T><N><Q><T><T><N><E><W><Y><R><G><D><W><A><W><C><Q><R><C><P><L><V><A><W><P><P><S><A><E><P><Q><V><H><R><N><I><H><S><H><G><L><R><S><N><L><Q><E><I><F><L><P><A><F><P><C><H><E><R><K><K><Q><E>
Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2.<BOP>
Q9NPG8
Q12899
TRI26_HUMAN
Zinc finger protein 173
Homo
<M><A><T><S><A><P><L><R><S><L><E><E><E><V><T><C><S><I><C><L><D><Y><L><R><D><P><V><T><I><D><C><G><H><V><F><C><R><S><C><T><T><D><V><R><P><I><S><G><S><R><P><V><C><P><L><C><K><K><P><F><K><K><E><N><I><R><P><V><W><Q><L><A><S><L><V><E><N><I><E><R><L><K><V><D><K><G><R><Q><P><G><E><V><T><R><E><Q><Q><D><A><K><L><C><E><R><H><R><E><K><L><H><Y><Y><C><E><D><D><G><K><L><L><C><V><M><C><R><E><S><R><E><H><R><P><H><T><A><V><L><M><E><K><A><A><Q><P><H><R><E><K><I><L><N><H><L><S><T><L><R><R><D><R><D><K><I><Q><G><F><Q><A><K><G><E><A><D><I><L><A><A><L><K><K><L><Q><D><Q><R><Q><Y><I><V><A><E><F><E><Q><G><H><Q><F><L><R><E><R><E><E><H><L><L><E><Q><L><A><K><L><E><Q><E><L><T><E><G><R><E><K><F><K><S><R><G><V><G><E><L><A><R><L><A><L><V><I><S><E><L><E><G><K><A><Q><Q><P><A><A><E><L><M><Q><D><T><R><D><F><L><N><R><Y><P><R><K><K><F><W><V><G><K><P><I><A><R><V><V><K><K><K><T><G><E><F><S><D><K><L><L><S><L><Q><R><G><L><R><E><F><Q><G><K><L><L><R><D><L><E><Y><K><T><V><S><V><T><L><D><P><Q><S><A><S><G><Y><L><Q><L><S><E><D><W><K><C><V><T><Y><T><S><L><Y><K><S><A><Y><L><H><P><Q><Q><F><D><C><E><P><G><V><L><G><S><K><G><F><T><W><G><K><V><Y><W><E><V><E><V><E><R><E><G><W><S><E><D><E><E><E><G><D><E><E><E><E><G><E><E><E><E><E><E><E><E><A><G><Y><G><D><G><Y><D><D><W><E><T><D><E><D><E><E><S><L><G><D><E><E><E><E><E><E><E><E><E><E><E><V><L><E><S><C><M><V><G><V><A><R><D><S><V><K><R><K><G><D><L><S><L><R><P><E><D><G><V><W><A><L><R><L><S><S><S><G><I><W><A><N><T><S><P><E><A><E><L><F><P><A><L><R><P><R><R><V><G><I><A><L><D><Y><E><G><G><T><V><T><F><T><N><A><E><S><Q><E><L><I><Y><T><F><T><A><T><F><T><R><R><L><V><P><F><L><W><L><K><W><P><G><T><R><L><L><L><R><P>
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.<BOP>
Q12899
Q8TCQ1
MARH1_HUMAN
RING-type E3 ubiquitin transferase MARCHF1
Homo
<M><L><G><W><C><E><A><I><A><R><N><P><H><R><I><P><N><N><T><R><T><P><E><I><S><G><D><L><A><D><A><S><Q><T><S><T><L><N><E><K><S><P><G><R><S><A><S><R><S><S><N><I><S><K><A><S><S><P><T><T><G><T><A><P><R><S><Q><S><R><L><S><V><C><P><S><T><Q><D><I><C><R><I><C><H><C><E><G><D><E><E><S><P><L><I><T><P><C><R><C><T><G><T><L><R><F><V><H><Q><S><C><L><H><Q><W><I><K><S><S><D><T><R><C><C><E><L><C><K><Y><D><F><I><M><E><T><K><L><K><P><L><R><K><W><E><K><L><Q><M><T><T><S><E><R><R><K><I><F><C><S><V><T><F><H><V><I><A><I><T><C><V><V><W><S><L><Y><V><L><I><D><R><T><A><E><E><I><K><Q><G><N><D><N><G><V><L><E><W><P><F><W><T><K><L><V><V><V><A><I><G><F><T><G><G><L><V><F><M><Y><V><Q><C><K><V><Y><V><Q><L><W><R><R><L><K><A><Y><N><R><V><I><F><V><Q><N><C><P><D><T><A><K><K><L><E><K><N><F><S><C><N><V><N><T><D><I><K><D><A><V><V><V><P><V><P><Q><T><G><A><N><S><L><P><S><A><E><G><G><P><P><E><V><V><S><V>
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.<BOP>
Q8TCQ1
P33778
H2B1B_HUMAN
Histone H2B.f
Homo
<M><P><E><P><S><K><S><A><P><A><P><K><K><G><S><K><K><A><I><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><I><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
P33778
Q8IVH4
MMAA_HUMAN
Methylmalonic aciduria type A protein, mitochondrial
Homo
<M><P><M><L><L><P><H><P><H><Q><H><F><L><K><G><L><L><R><A><P><F><R><C><Y><H><F><I><F><H><S><S><T><H><L><G><S><G><I><P><C><A><Q><P><F><N><S><L><G><L><H><C><T><K><W><M><L><L><S><D><G><L><K><R><K><L><C><V><Q><T><T><L><K><D><H><T><E><G><L><S><D><K><E><Q><R><F><V><D><K><L><Y><T><G><L><I><Q><G><Q><R><A><C><L><A><E><A><I><T><L><V><E><S><T><H><S><R><K><K><E><L><A><Q><V><L><L><Q><K><V><L><L><Y><H><R><E><Q><E><Q><S><N><K><G><K><P><L><A><F><R><V><G><L><S><G><P><P><G><A><G><K><S><T><F><I><E><Y><F><G><K><M><L><T><E><R><G><H><K><L><S><V><L><A><V><D><P><S><S><C><T><S><G><G><S><L><L><G><D><K><T><R><M><T><E><L><S><R><D><M><N><A><Y><I><R><P><S><P><T><R><G><T><L><G><G><V><T><R><T><T><N><E><A><I><L><L><C><E><G><A><G><Y><D><I><I><L><I><E><T><V><G><V><G><Q><S><E><F><A><V><A><D><M><V><D><M><F><V><L><L><L><P><P><A><G><G><D><E><L><Q><G><I><K><R><G><I><I><E><M><A><D><L><V><A><V><T><K><S><D><G><D><L><I><V><P><A><R><R><I><Q><A><E><Y><V><S><A><L><K><L><L><R><K><R><S><Q><V><W><K><P><K><V><I><R><I><S><A><R><S><G><E><G><I><S><E><M><W><D><K><M><K><D><F><Q><D><L><M><L><A><S><G><E><L><T><A><K><R><R><K><Q><Q><K><V><W><M><W><N><L><I><Q><E><S><V><L><E><H><F><R><T><H><P><T><V><R><E><Q><I><P><L><L><E><Q><K><V><L><I><G><A><L><S><P><G><L><A><A><D><F><L><L><K><A><F><K><S><R><D>
GTPase, binds and hydrolyzes GTP . Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis . Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) . Plays a dual role as both a protectase and a reactivase for MMUT . Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) . Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP .<BOP>
Q8IVH4
Q9HAF1
EAF6_HUMAN
Sarcoma antigen NY-SAR-91
Homo
<M><A><M><H><N><K><A><A><P><P><Q><I><P><D><T><R><R><E><L><A><E><L><V><K><R><K><Q><E><L><A><E><T><L><A><N><L><E><R><Q><I><Y><A><F><E><G><S><Y><L><E><D><T><Q><M><Y><G><N><I><I><R><G><W><D><R><Y><L><T><N><Q><K><N><S><N><S><K><N><D><R><R><N><R><K><F><K><E><A><E><R><L><F><S><K><S><S><V><T><S><A><A><A><V><S><A><L><A><G><V><Q><D><Q><L><I><E><K><R><E><P><G><S><G><T><E><S><D><T><S><P><D><F><H><N><Q><E><N><E><P><S><Q><E><D><P><E><D><L><D><G><S><V><Q><G><V><K><P><Q><K><A><A><S><S><T><S><S><G><S><H><H><S><S><H><K><K><R><K><N><K><N><R><H><R><I><D><L><K><L><N><K><K><P><R><A><D><Y>
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A . This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription . Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 . Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity .<BOP>
Q9HAF1
A0A087WT01
TVA27_HUMAN
T cell receptor alpha variable 27
Homo
<M><V><L><K><F><S><V><S><I><L><W><I><Q><L><A><W><V><S><T><Q><L><L><E><Q><S><P><Q><F><L><S><I><Q><E><G><E><N><L><T><V><Y><C><N><S><S><S><V><F><S><S><L><Q><W><Y><R><Q><E><P><G><E><G><P><V><L><L><V><T><V><V><T><G><G><E><V><K><K><L><K><R><L><T><F><Q><F><G><D><A><R><K><D><S><S><L><H><I><T><A><A><Q><T><G><D><T><G><L><Y><L><C><A><G>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearr
A0A087WT01
P0DPD5
ZN723_HUMAN
Zinc finger protein 723
Homo
<M><G><P><L><T><F><T><D><V><A><I><K><F><S><L><E><E><W><Q><F><L><D><T><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><F><L><G><V><G><V><S><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><M><K><R><H><K><M><V><A><K><P><P><V><V><C><S><H><F><A><Q><D><L><W><P><E><Q><G><I><K><D><S><F><Q><K><V><I><L><R><S><Y><G><K><Y><G><H><D><N><L><Q><L><R><K><G><C><E><S><V><D><E><C><K><M><H><K><G><G><Y><D><E><L><K><Q><C><L><T><T><T><P><S><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><F><S><S><S><N><S><Q><K><I><R><H><T><G><N><N><S><F><K><C><K><E><C><G><K><S><F><C><M><L><S><H><L><T><K><H><E><R><N><H><T><R><V><N><C><Y><K><C><E><E><C><G><K><A><F><S><V><P><S><K><L><N><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><V><S><S><S><L><N><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><T><F><N><M><F><S><S><L><N><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><N><V><F><S><S><L><N><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><P><S><H><L><A><T><H><K><R><I><H><T><G><E><K><L><Y><K><C><E><E><C><G><K><A><F><S><Q><S><S><H><I><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><V><S><V><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><A><L><T><T><H><K><I><I><H><T><G><E><R><P><Y><K><C><K><Q><C><G><K><G><F><S><Q><S><S><T><L><T><K><H><K><I><I><H><T><K><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><Y><S><T><L><N><K><H><K><I><I><H><A><R><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><K><S><S><I><L><N><R><H><K><I><I><H><T><K><E><K><S><Q><T><L><K><M>
May be involved in transcriptional regulation.<BOP>
P0DPD5
Q07108
CD69_HUMAN
MLR-3
Homo
<M><S><S><E><N><C><F><V><A><E><N><S><S><L><H><P><E><S><G><Q><E><N><D><A><T><S><P><H><F><S><T><R><H><E><G><S><F><Q><V><P><V><L><C><A><V><M><N><V><V><F><I><T><I><L><I><I><A><L><I><A><L><S><V><G><Q><Y><N><C><P><G><Q><Y><T><F><S><M><P><S><D><S><H><V><S><S><C><S><E><D><W><V><G><Y><Q><R><K><C><Y><F><I><S><T><V><K><R><S><W><T><S><A><Q><N><A><C><S><E><H><G><A><T><L><A><V><I><D><S><E><K><D><M><N><F><L><K><R><Y><A><G><R><E><E><H><W><V><G><L><K><K><E><P><G><H><P><W><K><W><S><N><G><K><E><F><N><N><W><F><N><V><T><G><S><D><K><C><V><F><L><K><N><T><E><V><S><S><M><E><C><E><K><N><L><Y><W><I><C><N><K><P><Y><K>
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.<BOP>
Q07108
A0A0B4J244
TVA3_HUMAN
T cell receptor alpha variable 3
Homo
<M><A><S><A><P><I><S><M><L><A><M><L><F><T><L><S><G><L><R><A><Q><S><V><A><Q><P><E><D><Q><V><N><V><A><E><G><N><P><L><T><V><K><C><T><Y><S><V><S><G><N><P><Y><L><F><W><Y><V><Q><Y><P><N><R><G><L><Q><F><L><L><K><Y><I><T><G><D><N><L><V><K><G><S><Y><G><F><E><A><E><F><N><K><S><Q><T><S><F><H><L><K><K><P><S><A><L><V><S><D><S><A><L><Y><F><C><A><V><R><D>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J244
O75596
CLC3A_HUMAN
Cartilage-derived C-type lectin
Homo
<M><A><K><N><G><L><V><I><C><I><L><V><I><T><L><L><L><D><Q><T><T><S><H><T><S><R><L><K><A><R><K><H><S><K><R><R><V><R><D><K><D><G><D><L><K><T><Q><I><E><K><L><W><T><E><V><N><A><L><K><E><I><Q><A><L><Q><T><V><C><L><R><G><T><K><V><H><K><K><C><Y><L><A><S><E><G><L><K><H><F><H><E><A><N><E><D><C><I><S><K><G><G><I><L><V><I><P><R><N><S><D><E><I><N><A><L><Q><D><Y><G><K><R><S><L><P><G><V><N><D><F><W><L><G><I><N><D><M><V><T><E><G><K><F><V><D><V><N><G><I><A><I><S><F><L><N><W><D><R><A><Q><P><N><G><G><K><R><E><N><C><V><L><F><S><Q><S><A><Q><G><K><W><S><D><E><A><C><R><S><S><K><R><Y><I><C><E><F><T><I><P><Q>
Promotes cell adhesion to laminin-332 and fibronectin.<BOP>
O75596
Q9NZD4
AHSP_HUMAN
Erythroid-associated factor
Homo
<M><A><L><L><K><A><N><K><D><L><I><S><A><G><L><K><E><F><S><V><L><L><N><Q><Q><V><F><N><D><P><L><V><S><E><E><D><M><V><T><V><V><E><D><W><M><N><F><Y><I><N><Y><Y><R><Q><Q><V><T><G><E><P><Q><E><R><D><K><A><L><Q><E><L><R><Q><E><L><N><T><L><A><N><P><F><L><A><K><Y><R><D><F><L><K><S><H><E><L><P><S><H><P><P><P><S><S>
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<BOP>
Q9NZD4
Q6MZQ0
PRR5L_HUMAN
Protein observed with Rictor-2
Homo
<M><T><R><G><F><A><P><I><L><P><V><E><F><H><K><M><G><S><F><R><R><P><R><P><R><F><M><S><S><P><V><L><S><D><L><P><R><F><Q><A><A><R><Q><A><L><Q><L><S><S><S><S><A><W><N><S><V><Q><T><A><V><I><N><V><F><K><G><G><G><L><Q><S><N><E><L><Y><A><L><N><E><N><I><R><R><L><L><K><S><E><L><G><S><F><I><T><D><Y><F><Q><N><Q><L><L><A><K><G><L><F><F><V><E><E><K><I><K><L><C><E><G><E><N><R><I><E><V><L><A><E><V><W><D><H><F><F><T><E><T><L><P><T><L><Q><A><I><F><Y><P><V><Q><G><Q><E><L><T><I><R><Q><I><S><L><L><G><F><R><D><L><V><L><L><K><V><K><L><G><D><L><L><L><L><A><Q><S><K><L><P><S><S><I><V><Q><M><L><L><I><L><Q><S><V><H><E><P><T><G><P><S><E><S><Y><L><Q><L><E><E><L><V><K><Q><V><V><S><P><F><L><G><I><S><G><D><R><S><F><S><G><P><T><Y><T><L><A><R><R><H><S><R><V><R><P><K><V><T><V><L><N><Y><A><S><P><I><T><A><V><S><R><P><L><N><E><M><V><L><T><P><L><T><E><Q><E><G><E><A><Y><L><E><K><C><G><S><V><R><R><H><T><V><A><N><A><H><S><D><I><Q><L><L><A><M><A><T><M><M><H><S><G><L><G><E><E><A><S><S><E><N><K><C><L><L><L><P><P><S><F><P><P><P><H><R><Q><C><S><S><E><P><N><I><T><D><N><P><D><G><L><E><E><G><A><R><G><S><Q><E><G><S><E><L><N><C><A><S><L><S>
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton . Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration . Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress . Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress .<BOP>
Q6MZQ0
P01920
DQB1_HUMAN
MHC class II antigen DQB1
Homo
<M><S><W><K><K><A><L><R><I><P><G><G><L><R><A><A><T><V><T><L><M><L><A><M><L><S><T><P><V><A><E><G><R><D><S><P><E><D><F><V><Y><Q><F><K><A><M><C><Y><F><T><N><G><T><E><R><V><R><Y><V><T><R><Y><I><Y><N><R><E><E><Y><A><R><F><D><S><D><V><E><V><Y><R><A><V><T><P><L><G><P><P><D><A><E><Y><W><N><S><Q><K><E><V><L><E><R><T><R><A><E><L><D><T><V><C><R><H><N><Y><Q><L><E><L><R><T><T><L><Q><R><R><V><E><P><T><V><T><I><S><P><S><R><T><E><A><L><N><H><H><N><L><L><V><C><S><V><T><D><F><Y><P><A><Q><I><K><V><R><W><F><R><N><D><Q><E><E><T><T><G><V><V><S><T><P><L><I><R><N><G><D><W><T><F><Q><I><L><V><M><L><E><M><T><P><Q><H><G><D><V><Y><T><C><H><V><E><H><P><S><L><Q><N><P><I><T><V><E><W><R><A><Q><S><E><S><A><Q><S><K><M><L><S><G><I><G><G><F><V><L><G><L><I><F><L><G><L><G><L><I><I><H><H><R><S><Q><K><G><L><L><H>
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To
P01920
P49662
CASP4_HUMAN
Caspase-4 subunit p20
Homo
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(Microbial infection) In response to the Td92 surface protein of the periodontal pathogen T.denticola, activated by cathepsin CTSG which leads to production and secretion of IL1A and pyroptosis of gingival fibroblasts.<BOP>
P49662