accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q92759 | TF2H4_HUMAN | TFIIH basal transcription factor complex p52 subunit | Homo | <M><E><S><T><P><S><R><G><L><N><R><V><H><L><Q><C><R><N><L><Q><E><F><L><G><G><L><S><P><G><V><L><D><R><L><Y><G><H><P><A><T><C><L><A><V><F><R><E><L><P><S><L><A><K><N><W><V><M><R><M><L><F><L><E><Q><P><L><P><Q><A><A><V><A><L><W><V><K><K><E><F><S><K><A><Q><E><E><S><T><G><L><L><S><G><L><R><I><W><H><T><Q><L><L><P><G><G><L><Q><G><L><I><L><N><P><I><F><R><Q><N><L><R><I><A><L><L><G><G><G><K><A><W><S><D><D><T><S><Q><L><G><P><D><K><H><A><R><D><V><P><S><L><D><K><Y><A><E><E><R><W><E><V><V><L><H><F><M><V><G><S><P><S><A><A><V><S><Q><D><L><A><Q><L><L><S><Q><A><G><L><M><K><S><T><E><P><G><E><P><P><C><I><T><S><A><G><F><Q><F><L><L><L><D><T><P><A><Q><L><W><Y><F><M><L><Q><Y><L><Q><T><A><Q><S><R><G><M><D><L><V><E><I><L><S><F><L><F><Q><L><S><F><S><T><L><G><K><D><Y><S><V><E><G><M><S><D><S><L><L><N><F><L><Q><H><L><R><E><F><G><L><V><F><Q><R><K><R><K><S><R><R><Y><Y><P><T><R><L><A><I><N><L><S><S><G><V><S><G><A><G><G><T><V><H><Q><P><G><F><I><V><V><E><T><N><Y><R><L><Y><A><Y><T><E><S><E><L><Q><I><A><L><I><A><L><F><S><E><M><L><Y><R><F><P><N><M><V><V><A><Q><V><T><R><E><S><V><Q><Q><A><I><A><S><G><I><T><A><Q><Q><I><I><H><F><L><R><T><R><A><H><P><V><M><L><K><Q><T><P><V><L><P><P><T><I><T><D><Q><I><R><L><W><E><L><E><R><D><R><L><R><F><T><E><G><V><L><Y><N><Q><F><L><S><Q><V><D><F><E><L><L><L><A><H><A><R><E><L><G><V><L><V><F><E><N><S><A><K><R><L><M><V><V><T><P><A><G><H><S><D><V><K><R><F><W><K><R><Q><K><H><S><S> | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.<BOP> | Q92759 |
Q9H5K3 | SG196_HUMAN | Sugen kinase 196 | Homo | <M><E><K><Q><P><Q><N><S><R><R><G><L><A><P><R><E><V><P><P><A><V><G><L><L><L><I><M><A><L><M><N><T><L><L><Y><L><C><L><D><H><F><F><I><A><P><R><Q><S><T><V><D><P><T><H><C><P><Y><G><H><F><R><I><G><Q><M><K><N><C><S><P><W><L><S><C><E><E><L><R><T><E><V><R><Q><L><K><R><V><G><E><G><A><V><K><R><V><F><L><S><E><W><K><E><H><K><V><A><L><S><Q><L><T><S><L><E><M><K><D><D><F><L><H><G><L><Q><M><L><K><S><L><Q><G><T><H><V><V><T><L><L><G><Y><C><E><D><D><N><T><M><L><T><E><Y><H><P><L><G><S><L><S><N><L><E><E><T><L><N><L><S><K><Y><Q><N><V><N><T><W><Q><H><R><L><E><L><A><M><D><Y><V><S><I><I><N><Y><L><H><H><S><P><V><G><T><R><V><M><C><D><S><N><D><L><P><K><T><L><S><Q><Y><L><L><T><S><N><F><S><I><L><A><N><D><L><D><A><L><P><L><V><N><H><S><S><G><M><L><V><K><C><G><H><R><E><L><H><G><D><F><V><A><P><E><Q><L><W><P><Y><G><E><D><V><P><F><H><D><D><L><M><P><S><Y><D><E><K><I><D><I><W><K><I><P><D><I><S><S><F><L><L><G><H><I><E><G><S><D><M><V><R><F><H><L><F><D><I><H><K><A><C><K><S><Q><T><P><S><E><R><P><T><A><Q><D><V><L><E><T><Y><Q><K><V><L><D><T><L><R><D><A><M><M><S><Q><A><R><E><M><L> | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.<BOP> | Q9H5K3 |
Q99717 | SMAD5_HUMAN | SMAD family member 5 | Homo | <M><T><S><M><A><S><L><F><S><F><T><S><P><A><V><K><R><L><L><G><W><K><Q><G><D><E><E><E><K><W><A><E><K><A><V><D><A><L><V><K><K><L><K><K><K><K><G><A><M><E><E><L><E><K><A><L><S><S><P><G><Q><P><S><K><C><V><T><I><P><R><S><L><D><G><R><L><Q><V><S><H><R><K><G><L><P><H><V><I><Y><C><R><V><W><R><W><P><D><L><Q><S><H><H><E><L><K><P><L><D><I><C><E><F><P><F><G><S><K><Q><K><E><V><C><I><N><P><Y><H><Y><K><R><V><E><S><P><V><L><P><P><V><L><V><P><R><H><N><E><F><N><P><Q><H><S><L><L><V><Q><F><R><N><L><S><H><N><E><P><H><M><P><Q><N><A><T><F><P><D><S><F><H><Q><P><N><N><T><P><F><P><L><S><P><N><S><P><Y><P><P><S><P><A><S><S><T><Y><P><N><S><P><A><S><S><G><P><G><S><P><F><Q><L><P><A><D><T><P><P><P><A><Y><M><P><P><D><D><Q><M><G><Q><D><N><S><Q><P><M><D><T><S><N><N><M><I><P><Q><I><M><P><S><I><S><S><R><D><V><Q><P><V><A><Y><E><E><P><K><H><W><C><S><I><V><Y><Y><E><L><N><N><R><V><G><E><A><F><H><A><S><S><T><S><V><L><V><D><G><F><T><D><P><S><N><N><K><S><R><F><C><L><G><L><L><S><N><V><N><R><N><S><T><I><E><N><T><R><R><H><I><G><K><G><V><H><L><Y><Y><V><G><G><E><V><Y><A><E><C><L><S><D><S><S><I><F><V><Q><S><R><N><C><N><F><H><H><G><F><H><P><T><T><V><C><K><I><P><S><S><C><S><L><K><I><F><N><N><Q><E><F><A><Q><L><L><A><Q><S><V><N><H><G><F><E><A><V><Y><E><L><T><K><M><C><T><I><R><M><S><F><V><K><G><W><G><A><E><Y><H><R><Q><D><V><T><S><T><P><C><W><I><E><I><H><L><H><G><P><L><Q><W><L><D><K><V><L><T><Q><M><G><S><P><L><N><P><I><S><S><V><S> | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).<BOP> | Q99717 |
Q07343 | PDE4B_HUMAN | PDE32 | Homo | <M><K><K><S><R><S><V><M><T><V><M><A><D><D><N><V><K><D><Y><F><E><C><S><L><S><K><S><Y><S><S><S><S><N><T><L><G><I><D><L><W><R><G><R><R><C><C><S><G><N><L><Q><L><P><P><L><S><Q><R><Q><S><E><R><A><R><T><P><E><G><D><G><I><S><R><P><T><T><L><P><L><T><T><L><P><S><I><A><I><T><T><V><S><Q><E><C><F><D><V><E><N><G><P><S><P><G><R><S><P><L><D><P><Q><A><S><S><S><A><G><L><V><L><H><A><T><F><P><G><H><S><Q><R><R><E><S><F><L><Y><R><S><D><S><D><Y><D><L><S><P><K><A><M><S><R><N><S><S><L><P><S><E><Q><H><G><D><D><L><I><V><T><P><F><A><Q><V><L><A><S><L><R><S><V><R><N><N><F><T><I><L><T><N><L><H><G><T><S><N><K><R><S><P><A><A><S><Q><P><P><V><S><R><V><N><P><Q><E><E><S><Y><Q><K><L><A><M><E><T><L><E><E><L><D><W><C><L><D><Q><L><E><T><I><Q><T><Y><R><S><V><S><E><M><A><S><N><K><F><K><R><M><L><N><R><E><L><T><H><L><S><E><M><S><R><S><G><N><Q><V><S><E><Y><I><S><N><T><F><L><D><K><Q><N><D><V><E><I><P><S><P><T><Q><K><D><R><E><K><K><K><K><Q><Q><L><M><T><Q><I><S><G><V><K><K><L><M><H><S><S><S><L><N><N><T><S><I><S><R><F><G><V><N><T><E><N><E><D><H><L><A><K><E><L><E><D><L><N><K><W><G><L><N><I><F><N><V><A><G><Y><S><H><N><R><P><L><T><C><I><M><Y><A><I><F><Q><E><R><D><L><L><K><T><F><R><I><S><S><D><T><F><I><T><Y><M><M><T><L><E><D><H><Y><H><S><D><V><A><Y><H><N><S><L><H><A><A><D><V><A><Q><S><T><H><V><L><L><S><T><P><A><L><D><A><V><F><T><D><L><E><I><L><A><A><I><F><A><A><A><I><H><D><V><D><H><P><G><V><S><N><Q><F><L><I><N><T><N><S><E><L><A><L><M><Y><N><D><E><S><V><L><E><N><H><H><L><A><V><G><F><K><L><L><Q><E><E><H><C><D><I><F><M><N><L><T><K><K><Q><R><Q><T><L><R><K><M><V><I><D><M><V><L><A><T><D><M><S><K><H><M><S><L><L><A><D><L><K><T><M><V><E><T><K><K><V><T><S><S><G><V><L><L><L><D><N><Y><T><D><R><I><Q><V><L><R><N><M><V><H><C><A><D><L><S><N><P><T><K><S><L><E><L><Y><R><Q><W><T><D><R><I><M><E><E><F><F><Q><Q><G><D><K><E><R><E><R><G><M><E><I><S><P><M><C><D><K><H><T><A><S><V><E><K><S><Q><V><G><F><I><D><Y><I><V><H><P><L><W><E><T><W><A><D><L><V><Q><P><D><A><Q><D><I><L><D><T><L><E><D><N><R><N><W><Y><Q><S><M><I><P><Q><S><P><S><P><P><L><D><E><Q><N><R><D><C><Q><G><L><M><E><K><F><Q><F><E><L><T><L><D><E><E><D><S><E><G><P><E><K><E><G><E><G><H><S><Y><F><S><S><T><K><T><L><C><V><I><D><P><E><N><R><D><S><L><G><E><T><D><I><D><I><A><T><E><D><K><S><P><V><D><T> | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<BOP> | Q07343 |
Q05513 | KPCZ_HUMAN | nPKC-zeta | Homo | <M><P><S><R><T><G><P><K><M><E><G><S><G><G><R><V><R><L><K><A><H><Y><G><G><D><I><F><I><T><S><V><D><A><A><T><T><F><E><E><L><C><E><E><V><R><D><M><C><R><L><H><Q><Q><H><P><L><T><L><K><W><V><D><S><E><G><D><P><C><T><V><S><S><Q><M><E><L><E><E><A><F><R><L><A><R><Q><C><R><D><E><G><L><I><I><H><V><F><P><S><T><P><E><Q><P><G><L><P><C><P><G><E><D><K><S><I><Y><R><R><G><A><R><R><W><R><K><L><Y><R><A><N><G><H><L><F><Q><A><K><R><F><N><R><R><A><Y><C><G><Q><C><S><E><R><I><W><G><L><A><R><Q><G><Y><R><C><I><N><C><K><L><L><V><H><K><R><C><H><G><L><V><P><L><T><C><R><K><H><M><D><S><V><M><P><S><Q><E><P><P><V><D><D><K><N><E><D><A><D><L><P><S><E><E><T><D><G><I><A><Y><I><S><S><S><R><K><H><D><S><I><K><D><D><S><E><D><L><K><P><V><I><D><G><M><D><G><I><K><I><S><Q><G><L><G><L><Q><D><F><D><L><I><R><V><I><G><R><G><S><Y><A><K><V><L><L><V><R><L><K><K><N><D><Q><I><Y><A><M><K><V><V><K><K><E><L><V><H><D><D><E><D><I><D><W><V><Q><T><E><K><H><V><F><E><Q><A><S><S><N><P><F><L><V><G><L><H><S><C><F><Q><T><T><S><R><L><F><L><V><I><E><Y><V><N><G><G><D><L><M><F><H><M><Q><R><Q><R><K><L><P><E><E><H><A><R><F><Y><A><A><E><I><C><I><A><L><N><F><L><H><E><R><G><I><I><Y><R><D><L><K><L><D><N><V><L><L><D><A><D><G><H><I><K><L><T><D><Y><G><M><C><K><E><G><L><G><P><G><D><T><T><S><T><F><C><G><T><P><N><Y><I><A><P><E><I><L><R><G><E><E><Y><G><F><S><V><D><W><W><A><L><G><V><L><M><F><E><M><M><A><G><R><S><P><F><D><I><I><T><D><N><P><D><M><N><T><E><D><Y><L><F><Q><V><I><L><E><K><P><I><R><I><P><R><F><L><S><V><K><A><S><H><V><L><K><G><F><L><N><K><D><P><K><E><R><L><G><C><R><P><Q><T><G><F><S><D><I><K><S><H><A><F><F><R><S><I><D><W><D><L><L><E><K><K><Q><A><L><P><P><F><Q><P><Q><I><T><D><D><Y><G><L><D><N><F><D><T><Q><F><T><S><E><P><V><Q><L><T><P><D><D><E><D><A><I><K><R><I><D><Q><S><E><F><E><G><F><E><Y><I><N><P><L><L><L><S><T><E><E><S><V> | Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance.<BOP> | Q05513 |
Q8WXF3 | REL3_HUMAN | Relaxin-3 A chain | Homo | <M><A><R><Y><M><L><L><L><L><L><A><V><W><V><L><T><G><E><L><W><P><G><A><E><A><R><A><A><P><Y><G><V><R><L><C><G><R><E><F><I><R><A><V><I><F><T><C><G><G><S><R><W><R><R><S><D><I><L><A><H><E><A><M><G><D><T><F><P><D><A><D><A><D><E><D><S><L><A><G><E><L><D><E><A><M><G><S><S><E><W><L><A><L><T><K><S><P><Q><A><F><Y><R><G><R><P><S><W><Q><G><T><P><G><V><L><R><G><S><R><D><V><L><A><G><L><S><S><S><C><C><K><W><G><C><S><K><S><E><I><S><S><L><C> | May play a role in neuropeptide signaling processes. Ligand for LGR7, RXFP3 and RXFP4.<BOP> | Q8WXF3 |
Q3SXZ3 | ZN718_HUMAN | Zinc finger protein 718 | Homo | <M><E><L><L><T><F><K><D><V><A><I><E><F><S><P><E><E><W><K><C><L><D><T><S><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><V><S><I><S><N><P><D><L><V><T><S><L><E><Q><R><K><E><P><Y><N><L><K><I><H><E><T><A><A><R><P><P><A><V><C><S><H><F><T><Q><N><L><W><T><V><Q><G><I><E><D><S><F><H><K><L><I><P><K><G><H><E><K><R><G><H><E><N><L><R><K><T><C><K><S><I><N><E><C><K><V><Q><K><G><G><Y><N><R><I><N><Q><C><L><L><T><T><Q><K><K><T><I><Q><S><N><I><C><V><K><V><F><H><K><F><S><N><S><N><K><D><K><I><R><Y><T><G><D><K><T><F><K><C><K><E><C><G><K><S><F><H><V><L><S><R><L><T><Q><H><K><R><I><H><T><G><E><N><P><Y><T><C><E><E><C><G><K><A><F><N><W><S><S><I><L><T><K><H><K><R><I><H><A><R><E><K><F><Y><K><C><E><E><C><G><K><G><F><T><R><S><S><H><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><I><C><E><K><C><G><K><A><F><N><Q><S><S><T><L><N><L><H><K><R><I><H><S><A><Q><K><Y><Y><K><C><E><E><C><G><K><A><F><K><W><S><S><S><L><N><E><H><K><R><I><H><A><G><E><K><P><F><S><C><E><E><C><G><N><V><F><T><T><S><S><D><F><A><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><S><F><N><R><S><T><T><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><N><W><S><S><T><L><N><V><H><K><R><I><H><S><G><K><N><P><Y><K><C><E><D><C><G><K><A><F><K><V><F><A><N><L><H><N><H><K><K><I><H><T><G><E><K><P><Y><I><C><K><Q><C><G><K><A><F><K><Q><S><S><H><L><N><K><H><K><K><I><H><T><V><D><K><P><Y><K><C><K><E><C><G><K><A><F><K><Q><Y><S><N><L><P><Q><H><K><R><T><H><T><G><G><K><F> | May be involved in transcriptional regulation.<BOP> | Q3SXZ3 |
P21462 | FPR1_HUMAN | N-formylpeptide chemoattractant receptor | Homo | <M><E><T><N><S><S><L><P><T><N><I><S><G><G><T><P><A><V><S><A><G><Y><L><F><L><D><I><I><T><Y><L><V><F><A><V><T><F><V><L><G><V><L><G><N><G><L><V><I><W><V><A><G><F><R><M><T><H><T><V><T><T><I><S><Y><L><N><L><A><V><A><D><F><C><F><T><S><T><L><P><F><F><M><V><R><K><A><M><G><G><H><W><P><F><G><W><F><L><C><K><F><V><F><T><I><V><D><I><N><L><F><G><S><V><F><L><I><A><L><I><A><L><D><R><C><V><C><V><L><H><P><V><W><T><Q><N><H><R><T><V><S><L><A><K><K><V><I><I><G><P><W><V><M><A><L><L><L><T><L><P><V><I><I><R><V><T><T><V><P><G><K><T><G><T><V><A><C><T><F><N><F><S><P><W><T><N><D><P><K><E><R><I><N><V><A><V><A><M><L><T><V><R><G><I><I><R><F><I><I><G><F><S><A><P><M><S><I><V><A><V><S><Y><G><L><I><A><T><K><I><H><K><Q><G><L><I><K><S><S><R><P><L><R><V><L><S><F><V><A><A><A><F><F><L><C><W><S><P><Y><Q><V><V><A><L><I><A><T><V><R><I><R><E><L><L><Q><G><M><Y><K><E><I><G><I><A><V><D><V><T><S><A><L><A><F><F><N><S><C><L><N><P><M><L><Y><V><F><M><G><Q><D><F><R><E><R><L><I><H><A><L><P><A><S><L><E><R><A><L><T><E><D><S><T><Q><T><S><D><T><A><T><N><S><T><L><P><S><A><E><V><E><L><Q><A><K> | High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors . Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release . This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system . Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release . Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis .<BOP> | P21462 |
O95944 | NCTR2_HUMAN | Natural killer cell p44-related protein | Homo | <M><A><W><R><A><L><H><P><L><L><L><L><L><L><L><F><P><G><S><Q><A><Q><S><K><A><Q><V><L><Q><S><V><A><G><Q><T><L><T><V><R><C><Q><Y><P><P><T><G><S><L><Y><E><K><K><G><W><C><K><E><A><S><A><L><V><C><I><R><L><V><T><S><S><K><P><R><T><M><A><W><T><S><R><F><T><I><W><D><D><P><D><A><G><F><F><T><V><T><M><T><D><L><R><E><E><D><S><G><H><Y><W><C><R><I><Y><R><P><S><D><N><S><V><S><K><S><V><R><F><Y><L><V><V><S><P><A><S><A><S><T><Q><T><S><W><T><P><R><D><L><V><S><S><Q><T><Q><T><Q><S><C><V><P><P><T><A><G><A><R><Q><A><P><E><S><P><S><T><I><P><V><P><S><Q><P><Q><N><S><T><L><R><P><G><P><A><A><P><I><A><L><V><P><V><F><C><G><L><L><V><A><K><S><L><V><L><S><A><L><L><V><W><W><G><D><I><W><W><K><T><M><M><E><L><R><S><L><D><T><Q><K><A><T><C><H><L><Q><Q><V><T><D><L><P><W><T><S><V><S><S><P><V><E><R><E><I><L><Y><H><T><V><A><R><T><K><I><S><D><D><D><D><E><H><T><L> | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<BOP> | O95944 |
O14904 | WNT9A_HUMAN | Protein Wnt-14 | Homo | <M><L><D><G><S><P><L><A><R><W><L><A><A><A><F><G><L><T><L><L><L><A><A><L><R><P><S><A><A><Y><F><G><L><T><G><S><E><P><L><T><I><L><P><L><T><L><E><P><E><A><A><A><Q><A><H><Y><K><A><C><D><R><L><K><L><E><R><K><Q><R><R><M><C><R><R><D><P><G><V><A><E><T><L><V><E><A><V><S><M><S><A><L><E><C><Q><F><Q><F><R><F><E><R><W><N><C><T><L><E><G><R><Y><R><A><S><L><L><K><R><G><F><K><E><T><A><F><L><Y><A><I><S><S><A><G><L><T><H><A><L><A><K><A><C><S><A><G><R><M><E><R><C><T><C><D><E><A><P><D><L><E><N><R><E><A><W><Q><W><G><G><C><G><D><N><L><K><Y><S><S><K><F><V><K><E><F><L><G><R><R><S><S><K><D><L><R><A><R><V><D><F><H><N><N><L><V><G><V><K><V><I><K><A><G><V><E><T><T><C><K><C><H><G><V><S><G><S><C><T><V><R><T><C><W><R><Q><L><A><P><F><H><E><V><G><K><H><L><K><H><K><Y><E><T><A><L><K><V><G><S><T><T><N><E><A><A><G><E><A><G><A><I><S><P><P><R><G><R><A><S><G><A><G><G><S><D><P><L><P><R><T><P><E><L><V><H><L><D><D><S><P><S><F><C><L><A><G><R><F><S><P><G><T><A><G><R><R><C><H><R><E><K><N><C><E><S><I><C><C><G><R><G><H><N><T><Q><S><R><V><V><T><R><P><C><Q><C><Q><V><R><W><C><C><Y><V><E><C><R><Q><C><T><Q><R><E><E><V><Y><T><C><K><G> | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.<BOP> | O14904 |
Q7Z6L0 | PRRT2_HUMAN | Dispanin subfamily B member 3 | Homo | <M><A><A><S><S><S><E><I><S><E><M><K><G><V><E><E><S><P><K><V><P><G><E><G><P><G><H><S><E><A><E><T><G><P><P><Q><V><L><A><G><V><P><D><Q><P><E><A><P><Q><P><G><P><N><T><T><A><A><P><V><D><S><G><P><K><A><G><L><A><P><E><T><T><E><T><P><A><G><A><S><E><T><A><Q><A><T><D><L><S><L><S><P><G><G><E><S><K><A><N><C><S><P><E><D><P><C><Q><E><T><V><S><K><P><E><V><S><K><E><A><T><A><D><Q><G><S><R><L><E><S><A><A><P><P><E><P><A><P><E><P><A><P><Q><P><D><P><R><P><D><S><Q><P><T><P><K><P><A><L><Q><P><E><L><P><T><Q><E><D><P><T><P><E><I><L><S><E><S><V><G><E><K><Q><E><N><G><A><V><V><P><L><Q><A><G><D><G><E><E><G><P><A><P><E><P><H><S><P><P><S><K><K><S><P><P><A><N><G><A><P><P><R><V><L><Q><Q><L><V><E><E><D><R><M><R><R><A><H><S><G><H><P><G><S><P><R><G><S><L><S><R><H><P><S><S><Q><L><A><G><P><G><V><E><G><G><E><G><T><Q><K><P><R><D><Y><I><I><L><A><I><L><S><C><F><C><P><M><W><P><V><N><I><V><A><F><A><Y><A><V><M><S><R><N><S><L><Q><Q><G><D><V><D><G><A><Q><R><L><G><R><V><A><K><L><L><S><I><V><A><L><V><G><G><V><L><I><I><I><A><S><C><V><I><N><L><G><V><Y><K> | As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation.<BOP> | Q7Z6L0 |
Q9NQY0 | BIN3_HUMAN | Bridging integrator 3 | Homo | <M><S><W><I><P><F><K><I><G><Q><P><K><K><Q><I><V><P><K><T><V><E><R><D><F><E><R><E><Y><G><K><L><Q><Q><L><E><E><Q><T><R><R><L><Q><K><D><M><K><K><S><T><D><A><D><L><A><M><S><K><S><A><V><K><I><S><L><D><L><L><S><N><P><L><C><E><Q><D><Q><D><L><L><N><M><V><T><A><L><D><T><A><M><K><R><M><D><A><F><N><Q><E><K><V><N><Q><I><Q><K><T><V><I><E><P><L><K><K><F><G><S><V><F><P><S><L><N><M><A><V><K><R><R><E><Q><A><L><Q><D><Y><R><R><L><Q><A><K><V><E><K><Y><E><E><K><E><K><T><G><P><V><L><A><K><L><H><Q><A><R><E><E><L><R><P><V><R><E><D><F><E><A><K><N><R><Q><L><L><E><E><M><P><R><F><Y><G><S><R><L><D><Y><F><Q><P><S><F><E><S><L><I><R><A><Q><V><V><Y><Y><S><E><M><H><K><I><F><G><D><L><S><H><Q><L><D><Q><P><G><H><S><D><E><Q><R><E><R><E><N><E><A><K><L><S><E><L><R><A><L><S><I><V><A><D><D> | Involved in cytokinesis and septation where it has a role in the localization of F-actin.<BOP> | Q9NQY0 |
Q5VU69 | CP141_HUMAN | Cilia- and flagella-associated protein 141 | Homo | <M><S><V><E><K><M><T><K><V><E><E><S><F><Q><K><A><M><G><L><K><K><T><V><D><R><W><R><N><S><H><T><H><C><L><W><Q><M><A><L><G><Q><R><R><N><P><Y><A><T><L><R><M><Q><D><T><M><V><Q><E><L><A><L><A><K><K><Q><L><L><M><V><R><Q><A><A><L><H><Q><L><F><E><K><E><H><Q><Q><Y><Q><Q><E><L><N><Q><M><G><K><A><F><Y><V><E><R><F> | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP> | Q5VU69 |
Q9BRR9 | RHG09_HUMAN | Rho-type GTPase-activating protein 9 | Homo | <M><L><S><S><R><W><W><P><S><S><W><G><I><L><G><L><G><P><R><S><P><P><R><G><S><Q><L><C><A><L><Y><A><F><T><Y><T><G><A><D><G><Q><Q><V><S><L><A><E><G><D><R><F><L><L><L><R><K><T><N><S><D><W><W><L><A><R><R><L><E><A><P><S><T><S><R><P><I><F><V><P><A><A><Y><M><I><E><E><S><I><P><S><Q><S><P><T><T><V><I><P><G><Q><L><L><W><T><P><G><P><K><L><F><H><G><S><L><E><E><L><S><Q><A><L><P><S><R><A><Q><A><S><S><E><Q><P><P><P><L><P><R><K><M><C><R><S><V><S><T><D><N><L><S><P><S><L><L><K><P><F><Q><E><G><P><S><G><R><S><L><S><Q><E><D><L><P><S><E><A><S><A><S><T><A><G><P><Q><P><L><M><S><E><P><P><V><Y><C><N><L><V><D><L><R><R><C><P><R><S><P><P><P><G><P><A><C><P><L><L><Q><R><L><D><A><W><E><Q><H><L><D><P><N><S><G><R><C><F><Y><I><N><S><L><T><G><C><K><S><W><K><P><P><R><R><S><R><S><E><T><N><P><G><S><M><E><G><T><Q><T><L><K><R><N><N><D><V><L><Q><P><Q><A><K><G><F><R><S><D><T><G><T><P><E><P><L><D><P><Q><G><S><L><S><L><S><Q><R><T><S><Q><L><D><P><P><A><L><Q><A><P><R><P><L><P><Q><L><L><D><D><P><H><E><V><E><K><S><G><L><L><N><M><T><K><I><A><Q><G><G><R><K><L><R><K><N><W><G><P><S><W><V><V><L><T><G><N><S><L><V><F><Y><R><E><P><P><P><T><A><P><S><S><G><W><G><P><A><G><S><R><P><E><S><S><V><D><L><R><G><A><A><L><A><H><G><R><H><L><S><S><R><R><N><V><L><H><I><R><T><I><P><G><H><E><F><L><L><Q><S><D><H><E><T><E><L><R><A><W><H><R><A><L><R><T><V><I><E><R><L><V><R><W><V><E><A><R><R><E><A><P><T><G><R><D><Q><G><S><G><D><R><E><N><P><L><E><L><R><L><S><G><S><G><P><A><E><L><S><A><G><E><D><E><E><E><E><S><E><L><V><S><K><P><L><L><R><L><S><S><R><R><S><S><I><R><G><P><E><G><T><E><Q><N><R><V><R><N><K><L><K><R><L><I><A><K><R><P><P><L><Q><S><L><Q><E><R><G><L><L><R><D><Q><V><F><G><C><Q><L><E><S><L><C><Q><R><E><G><D><T><V><P><S><F><L><R><L><C><I><A><A><V><D><K><R><G><L><D><V><D><G><I><Y><R><V><S><G><N><L><A><V><V><Q><K><L><R><F><L><V><D><R><E><R><A><V><T><S><D><G><R><Y><V><F><P><E><Q><P><G><Q><E><G><R><L><D><L><D><S><T><E><W><D><D><I><H><V><V><T><G><A><L><K><L><F><L><R><E><L><P><Q><P><L><V><P><P><L><L><L><P><H><F><R><A><A><L><A><L><S><E><S><E><Q><C><L><S><Q><I><Q><E><L><I><G><S><M><P><K><P><N><H><D><T><L><R><Y><L><L><E><H><L><C><R><V><I><A><H><S><D><K><N><R><M><T><P><H><N><L><G><I><V><F><G><P><T><L><F><R><P><E><Q><E><T><S><D><P><A><A><H><A><L><Y><P><G><Q><L><V><Q><L><M><L><T><N><F><T><S><L><F><P> | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.<BOP> | Q9BRR9 |
P09326 | CD48_HUMAN | TCT.1 | Homo | <M><C><S><R><G><W><D><S><C><L><A><L><E><L><L><L><L><P><L><S><L><L><V><T><S><I><Q><G><H><L><V><H><M><T><V><V><S><G><S><N><V><T><L><N><I><S><E><S><L><P><E><N><Y><K><Q><L><T><W><F><Y><T><F><D><Q><K><I><V><E><W><D><S><R><K><S><K><Y><F><E><S><K><F><K><G><R><V><R><L><D><P><Q><S><G><A><L><Y><I><S><K><V><Q><K><E><D><N><S><T><Y><I><M><R><V><L><K><K><T><G><N><E><Q><E><W><K><I><K><L><Q><V><L><D><P><V><P><K><P><V><I><K><I><E><K><I><E><D><M><D><D><N><C><Y><L><K><L><S><C><V><I><P><G><E><S><V><N><Y><T><W><Y><G><D><K><R><P><F><P><K><E><L><Q><N><S><V><L><E><T><T><L><M><P><H><N><Y><S><R><C><Y><T><C><Q><V><S><N><S><V><S><S><K><N><G><T><V><C><L><S><P><P><C><T><L><A><R><S><F><G><V><E><W><I><A><S><W><L><V><V><T><V><P><T><I><L><G><L><L><L><T> | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation . Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex . In turn, promotes LCK phosphorylation and subsequent activation . Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells .<BOP> | P09326 |
Q9UHD9 | UBQL2_HUMAN | Ubiquitin-like product Chap1/Dsk2 | Homo | <M><A><E><N><G><E><S><S><G><P><P><R><P><S><R><G><P><A><A><A><Q><G><S><A><A><A><P><A><E><P><K><I><I><K><V><T><V><K><T><P><K><E><K><E><E><F><A><V><P><E><N><S><S><V><Q><Q><F><K><E><A><I><S><K><R><F><K><S><Q><T><D><Q><L><V><L><I><F><A><G><K><I><L><K><D><Q><D><T><L><I><Q><H><G><I><H><D><G><L><T><V><H><L><V><I><K><S><Q><N><R><P><Q><G><Q><S><T><Q><P><S><N><A><A><G><T><N><T><T><S><A><S><T><P><R><S><N><S><T><P><I><S><T><N><S><N><P><F><G><L><G><S><L><G><G><L><A><G><L><S><S><L><G><L><S><S><T><N><F><S><E><L><Q><S><Q><M><Q><Q><Q><L><M><A><S><P><E><M><M><I><Q><I><M><E><N><P><F><V><Q><S><M><L><S><N><P><D><L><M><R><Q><L><I><M><A><N><P><Q><M><Q><Q><L><I><Q><R><N><P><E><I><S><H><L><L><N><N><P><D><I><M><R><Q><T><L><E><I><A><R><N><P><A><M><M><Q><E><M><M><R><N><Q><D><L><A><L><S><N><L><E><S><I><P><G><G><Y><N><A><L><R><R><M><Y><T><D><I><Q><E><P><M><L><N><A><A><Q><E><Q><F><G><G><N><P><F><A><S><V><G><S><S><S><S><S><G><E><G><T><Q><P><S><R><T><E><N><R><D><P><L><P><N><P><W><A><P><P><P><A><T><Q><S><S><A><T><T><S><T><T><T><S><T><G><S><G><S><G><N><S><S><S><N><A><T><G><N><T><V><A><A><A><N><Y><V><A><S><I><F><S><T><P><G><M><Q><S><L><L><Q><Q><I><T><E><N><P><Q><L><I><Q><N><M><L><S><A><P><Y><M><R><S><M><M><Q><S><L><S><Q><N><P><D><L><A><A><Q><M><M><L><N><S><P><L><F><T><A><N><P><Q><L><Q><E><Q><M><R><P><Q><L><P><A><F><L><Q><Q><M><Q><N><P><D><T><L><S><A><M><S><N><P><R><A><M><Q><A><L><M><Q><I><Q><Q><G><L><Q><T><L><A><T><E><A><P><G><L><I><P><S><F><T><P><G><V><G><V><G><V><L><G><T><A><I><G><P><V><G><P><V><T><P><I><G><P><I><G><P><I><V><P><F><T><P><I><G><P><I><G><P><I><G><P><T><G><P><A><A><P><P><G><S><T><G><S><G><G><P><T><G><P><T><V><S><S><A><A><P><S><E><T><T><S><P><T><S><E><S><G><P><N><Q><Q><F><I><Q><Q><M><V><Q><A><L><A><G><A><N><A><P><Q><L><P><N><P><E><V><R><F><Q><Q><Q><L><E><Q><L><N><A><M><G><F><L><N><R><E><A><N><L><Q><A><L><I><A><T><G><G><D><I><N><A><A><I><E><R><L><L><G><S><Q><P><S> | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome . Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome . Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion . Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin | Q9UHD9 |
Q9H910 | JUPI2_HUMAN | Hematological and neurological expressed 1-like protein | Homo | <M><F><Q><V><P><D><S><E><G><G><R><A><G><S><R><A><M><K><P><P><G><G><E><S><S><N><L><F><G><S><P><E><E><A><T><P><S><S><R><P><N><R><M><A><S><N><I><F><G><P><T><E><E><P><Q><N><I><P><K><R><T><N><P><P><G><G><K><G><S><G><I><F><D><E><S><T><P><V><Q><T><R><Q><H><L><N><P><P><G><G><K><T><S><D><I><F><G><S><P><V><T><A><T><S><R><L><A><H><P><N><K><P><K><D><H><V><F><L><C><E><G><E><E><P><K><S><D><L><K><A><A><R><S><I><P><A><G><A><E><P><G><E><K><G><S><A><R><K><A><G><P><A><K><E><Q><E><P><M><P><T><V><D><S><H><E><P><R><L><G><P><R><P><R><S><H><N><K><V><L><N><P><P><G><G><K><S><S><I><S><F><Y> | (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.<BOP> | Q9H910 |
Q14507 | EP3A_HUMAN | Human epididymis-specific protein 3-alpha | Homo | <M><T><S><S><L><K><I><W><G><I><L><L><A><L><L><C><I><L><C><R><L><C><V><Y><S><N><N><I><Y><W><R><E><F><I><K><L><H><Y><L><S><P><S><R><E><F><K><E><Y><K><C><D><V><L><M><R><E><K><E><A><L><K><G><K><S><F><H><M><F><I><Y><S><L><W><F><K><I><Q><R><A><C><I><N><E><K><G><S><D><R><Y><R><N><A><Y><V><W><A><P><G><A><L><K><V><L><E><C><H><W><E><K><Y><N><N><R><Y><T><E><S><R><S><F><S><Y><I><E><F><H><C><G><V><D><G><Y><V><D><N><I><E><D><L><R><I><I><E><P><I><S><N> | Possible function in sperm maturation.<BOP> | Q14507 |
Q9NV72 | ZN701_HUMAN | Zinc finger protein 701 | Homo | <M><G><F><L><H><V><G><Q><D><G><L><E><L><P><T><S><G><D><P><P><A><S><A><S><Q><S><A><G><I><T><G><V><S><H><R><T><Q><P><P><C><F><E><G><L><T><S><K><D><L><V><R><E><E><K><T><R><K><R><K><R><K><A><K><E><S><G><M><A><L><L><Q><G><L><L><T><F><R><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><D><T><S><S><K><C><M><M><K><M><F><S><S><T><G><Q><G><N><T><E><V><V><H><T><G><T><L><Q><I><H><A><S><H><H><I><G><D><T><C><F><Q><E><I><E><K><D><I><H><D><F><V><F><Q><W><Q><E><N><E><T><N><G><H><E><A><L><M><T><K><T><K><K><L><M><S><S><T><E><R><H><D><Q><R><H><A><G><N><K><P><I><K><N><E><L><G><S><S><F><H><S><H><L><P><E><V><H><I><F><H><P><E><G><K><I><G><N><Q><V><E><K><A><I><N><D><A><F><S><V><S><A><S><Q><R><I><S><C><R><P><K><T><R><I><S><N><K><Y><R><N><N><F><L><Q><S><S><L><L><T><Q><K><R><E><V><H><T><R><E><K><S><F><Q><R><N><E><S><G><K><A><F><N><G><S><S><L><L><K><K><H><Q><I><I><H><L><G><D><K><Q><Y><K><C><D><V><C><G><K><D><F><H><Q><K><R><Y><L><A><C><H><R><C><H><T><G><E><N><P><Y><T><C><N><E><C><G><K><T><F><S><H><N><S><A><L><L><V><H><K><A><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><N><Q><Q><S><N><L><A><R><H><H><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><V><F><S><R><K><S><H><L><E><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><R><R><D><S><H><L><A><Q><H><T><V><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><V><Q><N><S><S><L><V><M><H><K><V><I><H><T><G><E><K><R><Y><K><C><N><E><C><G><K><V><F><N><H><K><S><N><L><A><C><H><R><R><L><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><N><R><K><S><N><L><E><R><H><H><R><L><H><T><G><K><K><S> | May be involved in transcriptional regulation.<BOP> | Q9NV72 |
C0HLV8 | MP31_HUMAN | Micropeptide 31 | Homo | <M><W><R><D><S><L><C><A><A><A><G><Y><A><L><G><A><G><T><R><L><R><S><V><L><S><S><R><K><L><Q><P> | Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+) . Also inhibits cellular lactate utilization .<BOP> | C0HLV8 |
A6NK02 | TRI75_HUMAN | Tripartite motif-containing protein 75 | Homo | <M><A><V><A><A><A><L><T><G><L><Q><A><E><A><K><C><S><I><C><L><D><Y><L><S><D><P><V><T><I><E><C><G><H><N><F><C><R><S><C><I><Q><Q><S><W><L><D><L><Q><E><L><F><P><C><P><V><C><R><H><Q><C><Q><E><G><H><F><R><S><N><T><Q><L><G><R><M><I><E><I><A><K><L><L><Q><S><T><K><S><N><K><R><K><Q><E><E><T><T><L><C><E><K><H><N><Q><P><L><S><V><F><C><K><E><D><L><M><V><L><C><P><L><C><T><Q><P><P><D><H><Q><G><H><H><V><R><P><I><E><K><A><A><I><H><Y><R><K><R><F><C><S><Y><I><Q><P><L><K><K><Q><L><A><D><L><Q><K><L><I><S><T><Q><S><K><K><P><L><E><L><R><E><M><V><E><N><Q><R><Q><E><L><S><S><E><F><E><H><L><N><Q><F><L><D><R><E><Q><Q><A><V><L><S><R><L><A><E><E><E><K><D><N><Q><Q><K><L><S><A><N><I><T><A><F><S><N><Y><S><A><T><L><K><S><Q><L><S><K><V><V><E><L><S><E><L><S><E><L><E><L><L><S><Q><I><K><I><F><Y><E><S><E><N><E><S><S><P><S><I><F><S><I><H><L><K><R><D><G><C><S><F><P><P><Q><Y><S><A><L><Q><R><I><I><K><K><F><K><V><E><I><I><L><D><P><E><T><A><H><P><N><L><I><V><S><E><D><K><K><R><V><R><F><T><K><R><K><Q><K><V><P><G><F><P><K><R><F><T><V><K><P><V><V><L><G><F><P><Y><F><H><S><G><R><H><F><W><E><I><E><V><G><D><K><S><E><W><A><I><G><I><C><K><D><S><L><P><T><K><A><R><R><P><S><S><A><Q><Q><E><C><W><R><I><E><L><Q><D><D><G><Y><H><A><P><G><A><F><P><T><P><L><L><L><E><V><K><A><R><A><I><G><I><F><L><D><Y><E><M><G><E><I><S><F><Y><N><M><A><E><K><S><H><I><C><T><F><T><D><T><F><T><G><P><L><R><P><Y><F><Y><V><G><P><D><S><Q><P><L><R><I><C><T><G><T><V><C><E> | May play a role in female meiosis.<BOP> | A6NK02 |
Q5J8X5 | M4A13_HUMAN | Testis-expressed transmembrane protein 4 | Homo | <M><I><G><I><F><H><I><F><M><W><Y><F><L><L><V><L><Y><M><G><Q><I><K><G><A><F><G><T><Y><E><P><V><T><Y><K><T><G><C><T><L><W><G><I><F><F><I><I><A><G><V><F><L><I><R><V><T><K><Y><P><T><R><S><G><I><I><S><T><L><I><I><N><I><I><C><I><I><T><T><I><T><A><V><T><L><T><I><I><E><L><S><H><F><N><S><V><S><Y><R><N><Y><G><Q><A><K><L><G><R><E><V><S><R><I><L><L><F><F><Y><G><L><E><F><S><I><A><L><T><H><S><I><Y><S><C><S><N><L><F><R><R><Q><N><D><L><T><S><V><T><E><E><A><E><S><T><P> | May be involved in signal transduction as a component of a multimeric receptor complex.<BOP> | Q5J8X5 |
Q9NP08 | HMX1_HUMAN | Homeobox protein H6 | Homo | <M><P><D><E><L><T><E><P><G><R><A><T><P><A><R><A><S><S><F><L><I><E><N><L><L><A><A><E><A><K><G><A><G><R><A><T><Q><G><D><G><S><R><E><D><E><E><E><D><D><D><D><P><E><D><E><D><A><E><Q><A><R><R><R><R><L><Q><R><R><R><Q><L><L><A><G><T><G><P><G><G><E><A><R><A><R><A><L><L><G><P><G><A><L><G><L><G><P><R><P><P><P><G><P><G><P><P><F><A><L><G><C><G><G><A><A><R><W><Y><P><R><A><H><G><G><Y><G><G><G><L><S><P><D><T><S><D><R><D><S><P><E><T><G><E><E><M><G><R><A><E><G><A><W><P><R><G><P><G><P><G><A><V><Q><R><E><A><A><E><L><A><A><R><G><P><A><A><G><T><E><E><A><S><E><L><A><E><V><P><A><A><A><G><E><T><R><G><G><V><G><V><G><G><G><R><K><K><K><T><R><T><V><F><S><R><S><Q><V><F><Q><L><E><S><T><F><D><L><K><R><Y><L><S><S><A><E><R><A><G><L><A><A><S><L><Q><L><T><E><T><Q><V><K><I><W><F><Q><N><R><R><N><K><W><K><R><Q><L><A><A><E><L><E><A><A><S><L><S><P><P><G><A><Q><R><L><V><R><V><P><V><L><Y><H><E><S><P><P><A><A><A><A><A><G><P><P><A><T><L><P><F><P><L><A><P><A><A><P><A><P><P><P><P><L><L><G><F><S><G><A><L><A><Y><P><L><A><A><F><P><A><A><A><S><V><P><F><L><R><A><Q><M><P><G><L><V> | DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.<BOP> | Q9NP08 |
Q99543 | DNJC2_HUMAN | DnaJ homolog subfamily C member 2, N-terminally processed | Homo | <M><L><L><L><P><S><A><A><D><G><R><G><T><A><I><T><H><A><L><T><S><A><S><T><L><C><Q><V><E><P><V><G><R><W><F><E><A><F><V><K><R><R><N><R><N><A><S><A><S><F><Q><E><L><E><D><K><K><E><L><S><E><E><S><E><D><E><E><L><Q><L><E><E><F><P><M><L><K><T><L><D><P><K><D><W><K><N><Q><D><H><Y><A><V><L><G><L><G><H><V><R><Y><K><A><T><Q><R><Q><I><K><A><A><H><K><A><M><V><L><K><H><H><P><D><K><R><K><A><A><G><E><P><I><K><E><G><D><N><D><Y><F><T><C><I><T><K><A><Y><E><M><L><S><D><P><V><K><R><R><A><F><N><S><V><D><P><T><F><D><N><S><V><P><S><K><S><E><A><K><D><N><F><F><E><V><F><T><P><V><F><E><R><N><S><R><W><S><N><K><K><N><V><P><K><L><G><D><M><N><S><S><F><E><D><V><D><I><F><Y><S><F><W><Y><N><F><D><S><W><R><E><F><S><Y><L><D><E><E><E><K><E><K><A><E><C><R><D><E><R><R><W><I><E><K><Q><N><R><A><T><R><A><Q><R><K><K><E><E><M><N><R><I><R><T><L><V><D><N><A><Y><S><C><D><P><R><I><K><K><F><K><E><E><E><K><A><K><K><E><A><E><K><K><A><K><A><E><A><K><R><K><E><Q><E><A><K><E><K><Q><R><Q><A><E><L><E><A><A><R><L><A><K><E><K><E><E><E><E><V><R><Q><Q><A><L><L><A><K><K><E><K><D><I><Q><K><K><A><I><K><K><E><R><Q><K><L><R><N><S><C><K><T><W><N><H><F><S><D><N><E><A><E><R><V><K><M><M><E><E><V><E><K><L><C><D><R><L><E><L><A><S><L><Q><C><L><N><E><T><L><T><S><C><T><K><E><V><G><K><A><A><L><E><K><Q><I><E><E><I><N><E><Q><I><R><K><E><K><E><E><A><E><A><R><M><R><Q><A><S><K><N><T><E><K><S><T><G><G><G><G><N><G><S><K><N><W><S><E><D><D><L><Q><L><L><I><K><A><V><N><L><F><P><A><G><T><N><S><R><W><E><V><I><A><N><Y><M><N><I><H><S><S><S><G><V><K><R><T><A><K><D><V><I><G><K><A><K><S><L><Q><K><L><D><P><H><Q><K><D><D><I><N><K><K><A><F><D><K><F><K><K><E><H><G><V><V><P><Q><A><D><N><A><T><P><S><E><R><F><E><G><P><Y><T><D><F><T><P><W><T><T><E><E><Q><K><L><L><E><Q><A><L><K><T><Y><P><V><N><T><P><E><R><W><E><K><I><A><E><A><V><P><G><R><T><K><K><D><C><M><K><R><Y><K><E><L><V><E><M><V><K><A><K><K><A><A><Q><E><Q><V><L><N><A><S><R><A><K><K> | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.<BOP> | Q99543 |
Q9UN42 | AT1B4_HUMAN | X/potassium-transporting ATPase subunit beta-m | Homo | <M><R><R><Q><L><R><S><R><R><A><P><S><F><P><Y><S><Y><R><Y><R><L><D><D><P><D><E><A><N><Q><N><Y><L><A><D><E><E><E><E><A><E><E><E><A><R><V><T><V><V><P><K><S><E><E><E><E><E><E><E><E><K><E><E><E><E><E><E><E><K><E><E><E><E><G><Q><G><Q><P><T><G><N><A><W><W><Q><K><L><Q><I><M><S><E><Y><L><W><D><P><E><R><R><M><F><L><A><R><T><G><Q><S><W><S><L><I><L><L><I><Y><F><F><F><Y><A><S><L><A><A><V><I><T><L><C><M><Y><T><L><F><L><T><I><S><P><Y><I><P><T><F><T><E><R><V><K><P><P><G><V><M><I><R><P><F><A><H><S><L><N><F><N><F><N><V><S><E><P><D><T><W><Q><H><Y><V><I><S><L><N><G><F><L><Q><G><Y><N><D><S><L><Q><E><E><M><N><V><D><C><P><P><G><Q><Y><F><I><Q><D><G><N><E><D><E><D><K><K><A><C><Q><F><K><R><S><F><L><K><N><C><S><G><L><E><D><P><T><F><G><Y><S><T><G><Q><P><C><I><L><L><K><M><N><R><I><V><G><F><R><P><E><L><G><D><P><V><K><V><S><C><K><V><Q><R><G><D><E><N><D><I><R><S><I><S><Y><Y><P><E><S><A><S><F><D><L><R><Y><Y><P><Y><Y><G><K><L><T><H><V><N><Y><T><S><P><L><V><A><M><H><F><T><D><V><V><K><N><Q><A><V><P><V><Q><C><Q><L><K><G><K><G><V><I><N><D><V><I><N><D><R><F><V><G><R><V><I><F><T><L><N><I><E><T> | May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.<BOP> | Q9UN42 |
A0A075B6I3 | LVK55_HUMAN | Probable non-functional immunoglobulin lambda variable 11-55 | Homo | <M><A><L><T><P><L><L><L><L><L><L><S><H><C><T><G><S><L><S><R><P><V><L><T><Q><P><P><S><L><S><A><S><P><G><A><T><A><R><L><P><C><T><L><S><S><D><L><S><V><G><G><K><N><M><F><W><Y><Q><Q><K><L><G><S><S><P><R><L><F><L><Y><H><Y><S><D><S><D><K><Q><L><G><P><G><V><P><S><R><V><S><G><S><K><E><T><S><S><N><T><A><F><L><L><I><S><G><L><Q><P><E><D><E><A><D><Y><Y><C><Q><V><Y><E><S><S><A><N> | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection | A0A075B6I3 |
Q6GMV1 | ALG1L_HUMAN | Putative glycosyltransferase ALG1-like | Homo | <M><E><R><S><A><F><M><E><L><D><A><G><S><R><L><V><M><H><L><R><E><W><P><A><L><L><V><S><S><T><G><W><T><E><F><E><Q><L><T><L><D><G><H><N><L><P><S><L><V><C><V><I><T><G><S><V><D><L><G><V><C><L><H><M><S><S><S><G><L><D><L><P><M><K><V><V><D><M><F><G><C><C><L><P><V><C><A><V><N><F><K><C><L><H><E><L><V><K><H><E><E><N><G><L><V><F><E><D><S><E><E><L><A><A><L><Q><M><L><F><S><N><F><P><D><P><A><G><K><L><N><Q><F><W><K><N><L><R><E><S><Q><Q><L><R><W><D><E><S><W><V><Q><T><V><L><P><L><V><M><D><I><Q><L><L><G><Q><R><L><K><P><R><D><P><C><C><P><S><R><S><F><F><S><E><S><Q><G><K><P><F> | Putative glycosyltransferase.<BOP> | Q6GMV1 |
Q6UX15 | LAYN_HUMAN | Layilin | Homo | <M><R><P><G><T><A><L><Q><A><V><L><L><A><V><L><L><V><G><L><R><A><A><T><G><R><L><L><S><A><S><D><L><D><L><R><G><G><Q><P><V><C><R><G><G><T><Q><R><P><C><Y><K><V><I><Y><F><H><D><T><S><R><R><L><N><F><E><E><A><K><E><A><C><R><R><D><G><G><Q><L><V><S><I><E><S><E><D><E><Q><K><L><I><E><K><F><I><E><N><L><L><P><S><D><G><D><F><W><I><G><L><R><R><R><E><E><K><Q><S><N><S><T><A><C><Q><D><L><Y><A><W><T><D><G><S><I><S><Q><F><R><N><W><Y><V><D><E><P><S><C><G><S><E><V><C><V><V><M><Y><H><Q><P><S><A><P><A><G><I><G><G><P><Y><M><F><Q><W><N><D><D><R><C><N><M><K><N><N><F><I><C><K><Y><S><D><E><K><P><A><V><P><S><R><E><A><E><G><E><E><T><E><L><T><T><P><V><L><P><E><E><T><Q><E><E><D><A><K><K><T><F><K><E><S><R><E><A><A><L><N><L><A><Y><I><L><I><P><S><I><P><L><L><L><L><L><V><V><T><T><V><V><C><W><V><W><I><C><R><K><R><K><R><E><Q><P><D><P><S><T><K><K><Q><H><T><I><W><P><S><P><H><Q><G><N><S><P><D><L><E><V><Y><N><V><I><R><K><Q><S><E><A><D><L><A><E><T><R><P><D><L><K><N><I><S><F><R><V><C><S><G><E><A><T><P><D><D><M><S><C><D><Y><D><N><M><A><V><N><P><S><E><S><G><F><V><T><L><V><S><V><E><S><G><F><V><T><N><D><I><Y><E><F><S><P><D><Q><M><G><R><S><K><E><S><G><W><V><E><N><E><I><Y><G><Y> | Receptor for hyaluronate.<BOP> | Q6UX15 |
Q6UXK2 | ISLR2_HUMAN | Leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein | Homo | <M><F><P><L><R><A><L><W><L><V><W><A><L><L><G><V><A><G><S><C><P><E><P><C><A><C><V><D><K><Y><A><H><Q><F><A><D><C><A><Y><K><E><L><R><E><V><P><E><G><L><P><A><N><V><T><T><L><S><L><S><A><N><K><I><T><V><L><R><R><G><A><F><A><D><V><T><Q><V><T><S><L><W><L><A><H><N><E><V><R><T><V><E><P><G><A><L><A><V><L><S><Q><L><K><N><L><D><L><S><H><N><F><I><S><S><F><P><W><S><D><L><R><N><L><S><A><L><Q><L><L><K><M><N><H><N><R><L><G><S><L><P><R><D><A><L><G><A><L><P><D><L><R><S><L><R><I><N><N><N><R><L><R><T><L><A><P><G><T><F><D><A><L><S><A><L><S><H><L><Q><L><Y><H><N><P><F><H><C><G><C><G><L><V><W><L><Q><A><W><A><A><S><T><R><V><S><L><P><E><P><D><S><I><A><C><A><S><P><P><A><L><Q><G><V><P><V><Y><R><L><P><A><L><P><C><A><P><P><S><V><H><L><S><A><E><P><P><L><E><A><P><G><T><P><L><R><A><G><L><A><F><V><L><H><C><I><A><D><G><H><P><T><P><R><L><Q><W><Q><L><Q><I><P><G><G><T><V><V><L><E><P><P><V><L><S><G><E><D><D><G><V><G><A><E><E><G><E><G><E><G><D><G><D><L><L><T><Q><T><Q><A><Q><T><P><T><P><A><P><A><W><P><A><P><P><A><T><P><R><F><L><A><L><A><N><G><S><L><L><V><P><L><L><S><A><K><E><A><G><V><Y><T><C><R><A><H><N><E><L><G><A><N><S><T><S><I><R><V><A><V><A><A><T><G><P><P><K><H><A><P><G><A><G><G><E><P><D><G><Q><A><P><T><S><E><R><K><S><T><A><K><G><R><G><N><S><V><L><P><S><K><P><E><G><K><I><K><G><Q><G><L><A><K><V><S><I><L><G><E><T><E><T><E><P><E><E><D><T><S><E><G><E><E><A><E><D><Q><I><L><A><D><P><A><E><E><Q><R><C><G><N><G><D><P><S><R><Y><V><S><N><H><A><F><N><Q><S><A><E><L><K><P><H><V><F><E><L><G><V><I><A><L><D><V><A><E><R><E><A><R><V><Q><L><T><P><L><A><A><R><W><G><P><G><P><G><G><A><G><G><A><P><R><P><G><R><R><P><L><R><L><L><Y><L><C><P><A><G><G><G><A><A><V><Q><W><S><R><V><E><E><G><V><N><A><Y><W><F><R><G><L><R><P><G><T><N><Y><S><V><C><L><A><L><A><G><E><A><C><H><V><Q><V><V><F><S><T><K><K><E><L><P><S><L><L><V><I><V><A><V><S><V><F><L><L><V><L><A><T><V><P><L><L><G><A><A><C><C><H><L><L><A><K><H><P><G><K><P><Y><R><L><I><L><R><P><Q><A><P><D><P><M><E><K><R><I><A><A><D><F><D><P><R><A><S><Y><L><E><S><E><K><S><Y><P><A><G><G><E><A><G><G><E><E><P><E><D><V><Q><G><E><G><L><D><E><D><A><E><Q><G><D><P><S><G><D><L><Q><R><E><E><S><L><A><A><C><S><L><V><E><S><Q><S><K><A><N><Q><E><E><F><E><A><G><S><E><Y><S><D><R><L><P><L><G><A><E><A><V><N><I><A><Q><E><I><N><G><N><Y><R><Q><T><A><G> | Required for axon extension during neural development.<BOP> | Q6UXK2 |
Q13242 | SRSF9_HUMAN | Splicing factor, arginine/serine-rich 9 | Homo | <M><S><G><W><A><D><E><R><G><G><E><G><D><G><R><I><Y><V><G><N><L><P><T><D><V><R><E><K><D><L><E><D><L><F><Y><K><Y><G><R><I><R><E><I><E><L><K><N><R><H><G><L><V><P><F><A><F><V><R><F><E><D><P><R><D><A><E><D><A><I><Y><G><R><N><G><Y><D><Y><G><Q><C><R><L><R><V><E><F><P><R><T><Y><G><G><R><G><G><W><P><R><G><G><R><N><G><P><P><T><R><R><S><D><F><R><V><L><V><S><G><L><P><P><S><G><S><W><Q><D><L><K><D><H><M><R><E><A><G><D><V><C><Y><A><D><V><Q><K><D><G><V><G><M><V><E><Y><L><R><K><E><D><M><E><Y><A><L><R><K><L><D><D><T><K><F><R><S><H><E><G><E><T><S><Y><I><R><V><Y><P><E><R><S><T><S><Y><G><Y><S><R><S><R><S><G><S><R><G><R><D><S><P><Y><Q><S><R><G><S><P><H><Y><F><S><P><F><R><P><Y> | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.<BOP> | Q13242 |
Q9H5U6 | ZCHC4_HUMAN | Zinc finger CCHC domain-containing protein 4 | Homo | <M><A><A><S><R><N><G><F><E><A><V><E><A><E><G><S><A><G><C><R><G><S><S><G><M><E><V><V><L><P><L><D><P><A><V><P><A><P><L><C><P><H><G><P><T><L><L><F><V><K><V><T><Q><G><K><E><E><T><R><R><F><Y><A><C><S><A><C><R><D><R><K><D><C><N><F><F><Q><W><E><D><E><K><L><S><G><A><R><L><A><A><R><E><A><H><N><R><R><C><Q><P><P><L><S><R><T><Q><C><V><E><R><Y><L><K><F><I><E><L><P><L><T><Q><R><K><F><C><Q><T><C><Q><Q><L><L><L><P><D><D><W><G><Q><H><S><E><H><Q><V><L><G><N><V><S><I><T><Q><L><R><R><P><S><Q><L><L><Y><P><L><E><N><K><K><T><N><A><Q><Y><L><F><A><D><R><S><C><Q><F><L><V><D><L><L><S><A><L><G><F><R><R><V><L><C><V><G><T><P><R><L><H><E><L><I><K><L><T><A><S><G><D><K><K><S><N><I><K><S><L><L><L><D><I><D><F><R><Y><S><Q><F><Y><M><E><D><S><F><C><H><Y><N><M><F><N><H><H><F><F><D><G><K><T><A><L><E><V><C><R><A><F><L><Q><E><D><K><G><E><G><I><I><M><V><T><D><P><P><F><G><G><L><V><E><P><L><A><I><T><F><K><K><L><I><A><M><W><K><E><G><Q><S><Q><D><D><S><H><K><E><L><P><I><F><W><I><F><P><Y><F><F><E><S><R><I><C><Q><F><F><P><S><F><Q><M><L><D><Y><Q><V><D><Y><D><N><H><A><L><Y><K><H><G><K><T><G><R><K><Q><S><P><V><R><I><F><T><N><I><P><P><N><K><I><I><L><P><T><E><E><G><Y><R><F><C><S><P><C><Q><R><Y><V><S><L><E><N><Q><H><C><E><L><C><N><S><C><T><S><K><D><G><R><K><W><N><H><C><F><L><C><K><K><C><V><K><P><S><W><I><H><C><S><I><C><N><H><C><A><V><P><D><H><S><C><E><G><P><K><H><G><C><F><I><C><G><E><L><D><H><K><R><S><T><C><P><N><I><A><T><S><K><R><A><N><K><A><V><R><K><Q><K><Q><R><K><S><N><K><M><K><M><E><T><T><K><G><Q><S><M><N><H><T><S><A><T><R><R><K><K><R><R><E><R><A><H><Q><Y><L><G><S> | rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA . N6-methylation of adenine(4220) in 28S rRNA is required for translation .<BOP> | Q9H5U6 |
Q96EQ8 | RN125_HUMAN | T-cell RING activation protein 1 | Homo | <M><G><S><V><L><S><T><D><S><G><K><S><A><P><A><S><A><T><A><R><A><L><E><R><R><R><D><P><E><L><P><V><T><S><F><D><C><A><V><C><L><E><V><L><H><Q><P><V><R><T><R><C><G><H><V><F><C><R><S><C><I><A><T><S><L><K><N><N><K><W><T><C><P><Y><C><R><A><Y><L><P><S><E><G><V><P><A><T><D><V><A><K><R><M><K><S><E><Y><K><N><C><A><E><C><D><T><L><V><C><L><S><E><M><R><A><H><I><R><T><C><Q><K><Y><I><D><K><Y><G><P><L><Q><E><L><E><E><T><A><A><R><C><V><C><P><F><C><Q><R><E><L><Y><E><D><S><L><L><D><H><C><I><T><H><H><R><S><E><R><R><P><V><F><C><P><L><C><R><L><I><P><D><E><N><P><S><S><F><S><G><S><L><I><R><H><L><Q><V><S><H><T><L><F><Y><D><D><F><I><D><F><N><I><I><E><E><A><L><I><R><R><V><L><D><R><S><L><L><E><Y><V><N><H><S><N><T><T> | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 . Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation . Mediates ubiquitination and subsequent degradation of p53/TP53 . Mediates ubiquitination and subsequent degradation of JAK1 . Acts as a positive regulator of T-cell activation .<BOP> | Q96EQ8 |
Q9BU64 | CENPO_HUMAN | Interphase centromere complex protein 36 | Homo | <M><E><Q><A><N><P><L><R><P><D><G><E><S><K><G><G><V><L><A><H><L><E><R><L><E><T><Q><V><S><R><S><R><K><Q><S><E><E><L><Q><S><V><Q><A><Q><E><G><A><L><G><T><K><I><H><K><L><R><R><L><R><D><E><L><R><A><V><V><R><H><R><R><A><S><V><K><A><C><I><A><N><V><E><P><N><Q><T><V><E><I><N><E><Q><E><A><L><E><E><K><L><E><N><V><K><A><I><L><Q><A><Y><H><F><T><G><L><S><G><K><L><T><S><R><G><V><C><V><C><I><S><T><A><F><E><G><N><L><L><D><S><Y><F><V><D><L><V><I><Q><K><P><L><R><I><H><H><H><S><V><P><V><F><I><P><L><E><E><I><A><A><K><Y><L><Q><T><N><I><Q><H><F><L><F><S><L><C><E><Y><L><N><A><Y><S><G><R><K><Y><Q><A><D><R><L><Q><S><D><F><A><A><L><L><T><G><P><L><Q><R><N><P><L><C><N><L><L><S><F><T><Y><K><L><D><P><G><G><Q><S><F><P><F><C><A><R><L><L><Y><K><D><L><T><A><T><L><P><T><D><V><T><V><T><C><Q><G><V><E><V><L><S><T><S><W><E><E><Q><R><A><S><H><E><T><L><F><C><T><K><P><L><H><Q><V><F><A><S><F><T><R><K><G><E><K><L><D><M><S><L><V><S> | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.<BOP> | Q9BU64 |
Q96MA6 | KAD8_HUMAN | ATP-AMP transphosphorylase 8 | Homo | <M><D><A><T><I><A><P><H><R><I><P><P><E><M><P><Q><Y><G><E><E><N><H><I><F><E><L><M><Q><N><M><L><E><Q><L><L><I><H><Q><P><E><D><P><I><P><F><M><I><Q><H><L><H><R><D><N><D><N><V><P><R><I><V><I><L><G><P><P><A><S><G><K><T><T><I><A><M><W><L><C><K><H><L><N><S><S><L><L><T><L><E><N><L><I><L><N><E><F><S><Y><T><A><T><E><A><R><R><L><Y><L><Q><R><K><T><V><P><S><A><L><L><V><Q><L><I><Q><E><R><L><A><E><E><D><C><I><K><Q><G><W><I><L><D><G><I><P><E><T><R><E><Q><A><L><R><I><Q><T><L><G><I><T><P><R><H><V><I><V><L><S><A><P><D><T><V><L><I><E><R><N><L><G><K><R><I><D><P><Q><T><G><E><I><Y><H><T><T><F><D><W><P><P><E><S><E><I><Q><N><R><L><M><V><P><E><D><I><S><E><L><E><T><A><Q><K><L><L><E><Y><H><R><N><I><V><R><V><I><P><S><Y><P><K><I><L><K><V><I><S><A><D><Q><P><C><V><D><V><F><Y><Q><A><L><T><Y><V><Q><S><N><H><R><T><N><A><P><F><T><P><R><V><L><L><L><G><P><V><G><S><G><K><S><L><Q><A><A><L><L><A><Q><K><Y><R><L><V><N><V><C><C><G><Q><L><L><K><E><A><V><A><D><R><T><T><F><G><E><L><I><Q><P><F><F><E><K><E><M><A><V><P><D><S><L><L><M><K><V><L><S><Q><R><L><D><Q><Q><D><C><I><Q><K><G><W><V><L><H><G><V><P><R><D><L><D><Q><A><H><L><L><N><R><L><G><Y><N><P><N><R><V><F><F><L><N><V><P><F><D><S><I><M><E><R><L><T><L><R><R><I><D><P><V><T><G><E><R><Y><H><L><M><Y><K><P><P><P><T><M><E><I><Q><A><R><L><L><Q><N><P><K><D><A><E><E><Q><V><K><L><K><M><D><L><F><Y><R><N><S><A><D><L><E><Q><L><Y><G><S><A><I><T><L><N><G><D><Q><D><P><Y><T><V><F><E><Y><I><E><S><G><I><I><N><P><L><P><K><K><I><P> | Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.<BOP> | Q96MA6 |
P49448 | DHE4_HUMAN | Glutamate dehydrogenase 2, mitochondrial | Homo | <M><Y><R><Y><L><A><K><A><L><L><P><S><R><A><G><P><A><A><L><G><S><A><A><N><H><S><A><A><L><L><G><R><G><R><G><Q><P><A><A><A><S><Q><P><G><L><A><L><A><A><R><R><H><Y><S><E><L><V><A><D><R><E><D><D><P><N><F><F><K><M><V><E><G><F><F><D><R><G><A><S><I><V><E><D><K><L><V><K><D><L><R><T><Q><E><S><E><E><Q><K><R><N><R><V><R><G><I><L><R><I><I><K><P><C><N><H><V><L><S><L><S><F><P><I><R><R><D><D><G><S><W><E><V><I><E><G><Y><R><A><Q><H><S><Q><H><R><T><P><C><K><G><G><I><R><Y><S><T><D><V><S><V><D><E><V><K><A><L><A><S><L><M><T><Y><K><C><A><V><V><D><V><P><F><G><G><A><K><A><G><V><K><I><N><P><K><N><Y><T><E><N><E><L><E><K><I><T><R><R><F><T><M><E><L><A><K><K><G><F><I><G><P><G><V><D><V><P><A><P><D><M><N><T><G><E><R><E><M><S><W><I><A><D><T><Y><A><S><T><I><G><H><Y><D><I><N><A><H><A><C><V><T><G><K><P><I><S><Q><G><G><I><H><G><R><I><S><A><T><G><R><G><V><F><H><G><I><E><N><F><I><N><E><A><S><Y><M><S><I><L><G><M><T><P><G><F><R><D><K><T><F><V><V><Q><G><F><G><N><V><G><L><H><S><M><R><Y><L><H><R><F><G><A><K><C><I><A><V><G><E><S><D><G><S><I><W><N><P><D><G><I><D><P><K><E><L><E><D><F><K><L><Q><H><G><S><I><L><G><F><P><K><A><K><P><Y><E><G><S><I><L><E><V><D><C><D><I><L><I><P><A><A><T><E><K><Q><L><T><K><S><N><A><P><R><V><K><A><K><I><I><A><E><G><A><N><G><P><T><T><P><E><A><D><K><I><F><L><E><R><N><I><L><V><I><P><D><L><Y><L><N><A><G><G><V><T><V><S><Y><F><E><W><L><K><N><L><N><H><V><S><Y><G><R><L><T><F><K><Y><E><R><D><S><N><Y><H><L><L><L><S><V><Q><E><S><L><E><R><K><F><G><K><H><G><G><T><I><P><I><V><P><T><A><E><F><Q><D><S><I><S><G><A><S><E><K><D><I><V><H><S><A><L><A><Y><T><M><E><R><S><A><R><Q><I><M><H><T><A><M><K><Y><N><L><G><L><D><L><R><T><A><A><Y><V><N><A><I><E><K><V><F><K><V><Y><S><E><A><G><V><T><F><T> | Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.<BOP> | P49448 |
Q9H7B4 | SMYD3_HUMAN | Zinc finger MYND domain-containing protein 1 | Homo | <M><E><P><L><K><V><E><K><F><A><T><A><K><R><G><N><G><L><R><A><V><T><P><L><R><P><G><E><L><L><F><R><S><D><P><L><A><Y><T><V><C><K><G><S><R><G><V><V><C><D><R><C><L><L><G><K><E><K><L><M><R><C><S><Q><C><R><V><A><K><Y><C><S><A><K><C><Q><K><K><A><W><P><D><H><K><R><E><C><K><C><L><K><S><C><K><P><R><Y><P><P><D><S><V><R><L><L><G><R><V><V><F><K><L><M><D><G><A><P><S><E><S><E><K><L><Y><S><F><Y><D><L><E><S><N><I><N><K><L><T><E><D><K><K><E><G><L><R><Q><L><V><M><T><F><Q><H><F><M><R><E><E><I><Q><D><A><S><Q><L><P><P><A><F><D><L><F><E><A><F><A><K><V><I><C><N><S><F><T><I><C><N><A><E><M><Q><E><V><G><V><G><L><Y><P><S><I><S><L><L><N><H><S><C><D><P><N><C><S><I><V><F><N><G><P><H><L><L><L><R><A><V><R><D><I><E><V><G><E><E><L><T><I><C><Y><L><D><M><L><M><T><S><E><E><R><R><K><Q><L><R><D><Q><Y><C><F><E><C><D><C><F><R><C><Q><T><Q><D><K><D><A><D><M><L><T><G><D><E><Q><V><W><K><E><V><Q><E><S><L><K><K><I><E><E><L><K><A><H><W><K><W><E><Q><V><L><A><M><C><Q><A><I><I><S><S><N><S><E><R><L><P><D><I><N><I><Y><Q><L><K><V><L><D><C><A><M><D><A><C><I><N><L><G><L><L><E><E><A><L><F><Y><G><T><R><T><M><E><P><Y><R><I><F><F><P><G><S><H><P><V><R><G><V><Q><V><M><K><V><G><K><L><Q><L><H><Q><G><M><F><P><Q><A><M><K><N><L><R><L><A><F><D><I><M><R><V><T><H><G><R><E><H><S><L><I><E><D><L><I><L><L><L><E><E><C><D><A><N><I><R><A><S> | Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation . Also methylates 'Lys-5' of histone H4 . Plays an important role in transcriptional activation as a member of an RNA polymerase complex . Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences .<BOP> | Q9H7B4 |
P53667 | LIMK1_HUMAN | LIM domain kinase 1 | Homo | <M><R><L><T><L><L><C><C><T><W><R><E><E><R><M><G><E><E><G><S><E><L><P><V><C><A><S><C><G><Q><R><I><Y><D><G><Q><Y><L><Q><A><L><N><A><D><W><H><A><D><C><F><R><C><C><D><C><S><A><S><L><S><H><Q><Y><Y><E><K><D><G><Q><L><F><C><K><K><D><Y><W><A><R><Y><G><E><S><C><H><G><C><S><E><Q><I><T><K><G><L><V><M><V><A><G><E><L><K><Y><H><P><E><C><F><I><C><L><T><C><G><T><F><I><G><D><G><D><T><Y><T><L><V><E><H><S><K><L><Y><C><G><H><C><Y><Y><Q><T><V><V><T><P><V><I><E><Q><I><L><P><D><S><P><G><S><H><L><P><H><T><V><T><L><V><S><I><P><A><S><S><H><G><K><R><G><L><S><V><S><I><D><P><P><H><G><P><P><G><C><G><T><E><H><S><H><T><V><R><V><Q><G><V><D><P><G><C><M><S><P><D><V><K><N><S><I><H><V><G><D><R><I><L><E><I><N><G><T><P><I><R><N><V><P><L><D><E><I><D><L><L><I><Q><E><T><S><R><L><L><Q><L><T><L><E><H><D><P><H><D><T><L><G><H><G><L><G><P><E><T><S><P><L><S><S><P><A><Y><T><P><S><G><E><A><G><S><S><A><R><Q><K><P><V><L><R><S><C><S><I><D><R><S><P><G><A><G><S><L><G><S><P><A><S><Q><R><K><D><L><G><R><S><E><S><L><R><V><V><C><R><P><H><R><I><F><R><P><S><D><L><I><H><G><E><V><L><G><K><G><C><F><G><Q><A><I><K><V><T><H><R><E><T><G><E><V><M><V><M><K><E><L><I><R><F><D><E><E><T><Q><R><T><F><L><K><E><V><K><V><M><R><C><L><E><H><P><N><V><L><K><F><I><G><V><L><Y><K><D><K><R><L><N><F><I><T><E><Y><I><K><G><G><T><L><R><G><I><I><K><S><M><D><S><Q><Y><P><W><S><Q><R><V><S><F><A><K><D><I><A><S><G><M><A><Y><L><H><S><M><N><I><I><H><R><D><L><N><S><H><N><C><L><V><R><E><N><K><N><V><V><V><A><D><F><G><L><A><R><L><M><V><D><E><K><T><Q><P><E><G><L><R><S><L><K><K><P><D><R><K><K><R><Y><T><V><V><G><N><P><Y><W><M><A><P><E><M><I><N><G><R><S><Y><D><E><K><V><D><V><F><S><F><G><I><V><L><C><E><I><I><G><R><V><N><A><D><P><D><Y><L><P><R><T><M><D><F><G><L><N><V><R><G><F><L><D><R><Y><C><P><P><N><C><P><P><S><F><F><P><I><T><V><R><C><C><D><L><D><P><E><K><R><P><S><F><V><K><L><E><H><W><L><E><T><L><R><M><H><L><A><G><H><L><P><L><G><P><Q><L><E><Q><L><D><R><G><F><W><E><T><Y><R><R><G><E><S><G><L><P><A><H><P><E><V><P><D> | Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).<BOP> | P53667 |
P20671 | H2A1D_HUMAN | Histone H2A/g | Homo | <M><S><G><R><G><K><Q><G><G><K><A><R><A><K><A><K><T><R><S><S><R><A><G><L><Q><F><P><V><G><R><V><H><R><L><L><R><K><G><N><Y><S><E><R><V><G><A><G><A><P><V><Y><L><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><K><V><T><I><A><Q><G><G><V><L><P><N><I><Q><A><V><L><L><P><K><K><T><E><S><H><H><K><A><K><G><K> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | P20671 |
Q68G74 | LHX8_HUMAN | LIM/homeobox protein Lhx8 | Homo | <M><Q><I><L><S><R><C><Q><G><L><M><S><E><E><C><G><R><T><T><A><L><A><A><G><R><T><R><K><G><A><G><E><E><G><L><V><S><P><E><G><A><G><D><E><D><S><C><S><S><S><A><P><L><S><P><S><S><S><P><R><S><M><A><S><G><S><G><C><P><P><G><K><C><V><C><N><S><C><G><L><E><I><V><D><K><Y><L><L><K><V><N><D><L><C><W><H><V><R><C><L><S><C><S><V><C><R><T><S><L><G><R><H><T><S><C><Y><I><K><D><K><D><I><F><C><K><L><D><Y><F><R><R><Y><G><T><R><C><S><R><C><G><R><H><I><H><S><T><D><W><V><R><R><A><K><G><N><V><Y><H><L><A><C><F><A><C><F><S><C><K><R><Q><L><S><T><G><E><E><F><A><L><V><E><E><K><V><L><C><R><V><H><Y><D><C><M><L><D><N><L><K><R><E><V><E><N><G><N><G><I><S><V><E><G><A><L><L><T><E><Q><D><V><N><H><P><K><P><A><K><R><A><R><T><S><F><T><A><D><Q><L><Q><V><M><Q><A><Q><F><A><Q><D><N><N><P><D><A><Q><T><L><Q><K><L><A><E><R><T><G><L><S><R><R><V><I><Q><V><W><F><Q><N><C><R><A><R><H><K><K><H><V><S><P><N><H><S><S><S><T><P><V><T><A><V><P><P><S><R><L><S><P><P><M><L><E><E><M><A><Y><S><A><Y><V><P><Q><D><G><T><M><L><T><A><L><H><S><Y><M><D><A><H><S><P><T><T><L><G><L><Q><P><L><L><P><H><S><M><T><Q><L><P><I><S><H><T> | Transcription factor involved in differentiation of certain neurons and mesenchymal cells.<BOP> | Q68G74 |
Q6UW01 | CBLN3_HUMAN | Cerebellin-3 | Homo | <M><L><G><A><K><P><H><W><L><P><G><P><L><H><S><P><G><L><P><L><V><L><V><L><L><A><L><G><A><G><W><A><Q><E><G><S><E><P><V><L><L><E><G><E><C><L><V><V><C><E><P><G><R><A><A><A><G><G><P><G><G><A><A><L><G><E><A><P><P><G><R><V><A><F><A><A><V><R><S><H><H><H><E><P><A><G><E><T><G><N><G><T><S><G><A><I><Y><F><D><Q><V><L><V><N><E><G><G><G><F><D><R><A><S><G><S><F><V><A><P><V><R><G><V><Y><S><F><R><F><H><V><V><K><V><Y><N><R><Q><T><V><Q><V><S><L><M><L><N><T><W><P><V><I><S><A><F><A><N><D><P><D><V><T><R><E><A><A><T><S><S><V><L><L><P><L><D><P><G><D><R><V><S><L><R><L><R><R><G><N><L><L><G><G><W><K><Y><S><S><F><S><G><F><L><I><F><P><L> | May be involved in synaptic functions in the CNS.<BOP> | Q6UW01 |
Q9UGQ3 | GTR6_HUMAN | Glucose transporter type 6 | Homo | <M><Q><E><P><L><L><G><A><E><G><P><D><Y><D><T><F><P><E><K><P><P><P><S><P><G><D><R><A><R><V><G><T><L><Q><N><K><R><V><F><L><A><T><F><A><A><V><L><G><N><F><S><F><G><Y><A><L><V><Y><T><S><P><V><I><P><A><L><E><R><S><L><D><P><D><L><H><L><T><K><S><Q><A><S><W><F><G><S><V><F><T><L><G><A><A><A><G><G><L><S><A><M><I><L><N><D><L><L><G><R><K><L><S><I><M><F><S><A><V><P><S><A><A><G><Y><A><L><M><A><G><A><H><G><L><W><M><L><L><L><G><R><T><L><T><G><F><A><G><G><L><T><A><A><C><I><P><V><Y><V><S><E><I><A><P><P><G><V><R><G><A><L><G><A><T><P><Q><L><M><A><V><F><G><S><L><S><L><Y><A><L><G><L><L><L><P><W><R><W><L><A><V><A><G><E><A><P><V><L><I><M><I><L><L><L><S><F><M><P><N><S><P><R><F><L><L><S><R><G><R><D><E><E><A><L><R><A><L><A><W><L><R><G><T><D><V><D><V><H><W><E><F><E><Q><I><Q><D><N><V><R><R><Q><S><S><R><V><S><W><A><E><A><R><A><P><H><V><C><R><P><I><T><V><A><L><L><M><R><L><L><Q><Q><L><T><G><I><T><P><I><L><V><Y><L><Q><S><I><F><D><S><T><A><V><L><L><P><P><K><D><D><A><A><I><V><G><A><V><R><L><L><S><V><L><I><A><A><L><T><M><D><L><A><G><R><K><V><L><L><F><V><S><A><A><I><M><F><A><A><N><L><T><L><G><L><Y><I><H><F><G><P><R><P><L><S><P><N><S><T><A><G><L><E><S><E><S><W><G><D><L><A><Q><P><L><A><A><P><A><G><Y><L><T><L><V><P><L><L><A><T><M><L><F><I><M><G><Y><A><V><G><W><G><P><I><T><W><L><L><M><S><E><V><L><P><L><R><A><R><G><V><A><S><G><L><C><V><L><A><S><W><L><T><A><F><V><L><T><K><S><F><L><P><V><V><S><T><F><G><L><Q><V><P><F><F><F><F><A><A><I><C><L><V><S><L><V><F><T><G><C><C><V><P><E><T><K><G><R><S><L><E><Q><I><E><S><F><F><R><T><G><R><R><S><F><L><R> | Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose .<BOP> | Q9UGQ3 |
Q9BUR5 | MIC26_HUMAN | Protein FAM121B | Homo | <M><F><K><V><I><Q><R><S><V><G><P><A><S><L><S><L><L><T><F><K><V><Y><A><A><P><K><K><D><S><P><P><K><N><S><V><K><V><D><E><L><S><L><Y><S><V><P><E><G><Q><S><K><Y><V><E><E><A><R><S><Q><L><E><E><S><I><S><Q><L><R><H><Y><C><E><P><Y><T><T><W><C><Q><E><T><Y><S><Q><T><K><P><K><M><Q><S><L><V><Q><W><G><L><D><S><Y><D><Y><L><Q><N><A><P><P><G><F><F><P><R><L><G><V><I><G><F><A><G><L><I><G><L><L><L><A><R><G><S><K><I><K><K><L><V><Y><P><P><G><F><M><G><L><A><A><S><L><Y><Y><P><Q><Q><A><I><V><F><A><Q><V><S><G><E><R><L><Y><D><W><G><L><R><G><Y><I><V><I><E><D><L><W><K><E><N><F><Q><K><P><G><N><V><K><N><S><P><G><T><K> | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function . Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts . Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL .<BOP> | Q9BUR5 |
Q400G9 | AMZ1_HUMAN | Archeobacterial metalloproteinase-like protein 1 | Homo | <M><L><Q><C><R><P><A><Q><E><F><S><F><G><P><R><A><L><K><D><A><L><V><S><T><D><A><A><L><Q><Q><L><Y><V><S><A><F><S><P><A><E><R><L><F><L><A><E><A><Y><N><P><Q><R><T><L><F><C><T><L><L><I><R><T><G><F><D><W><L><L><S><R><P><E><A><P><E><D><F><Q><T><F><H><A><S><L><Q><H><R><K><P><R><L><A><R><K><H><I><Y><L><Q><P><I><D><L><S><E><E><P><V><G><S><S><L><L><H><Q><L><C><S><C><T><E><A><F><F><L><G><L><R><V><K><C><L><P><S><V><A><A><A><S><I><R><C><S><S><R><P><S><R><D><S><D><R><L><Q><L><H><T><D><G><I><L><S><F><L><K><N><N><K><P><G><D><A><L><C><V><L><G><L><T><L><S><D><L><Y><P><H><E><A><W><S><F><T><F><S><K><F><L><P><G><H><E><V><G><V><C><S><F><A><R><F><S><G><E><F><P><K><S><G><P><S><A><P><D><L><A><L><V><E><A><A><A><D><G><P><E><A><P><L><Q><D><R><G><W><A><L><C><F><S><A><L><G><M><V><Q><C><C><K><V><T><C><H><E><L><C><H><L><L><G><L><G><N><C><R><W><L><R><C><L><M><Q><G><A><L><S><L><D><E><A><L><R><R><P><L><D><L><C><P><I><C><L><R><K><L><Q><H><V><L><G><F><R><L><I><E><R><Y><Q><R><L><Y><T><W><T><Q><A><V><V><G><T><W><P><S><Q><E><A><G><E><P><S><V><W><E><D><T><P><P><A><S><A><D><S><G><M><C><C><E><S><D><S><E><P><G><T><S><V><S><E><P><L><T><P><D><A><G><S><H><T><F><A><S><G><P><E><E><G><L><S><Y><L><A><A><S><E><A><P><L><P><P><G><G><P><A><E><A><I><K><E><H><E><R><W><L><A><M><C><I><Q><A><L><Q><R><E><V><A><E><E><D><L><V><Q><V><D><R><A><V><D><A><L><D><R><W><E><M><F><T><G><Q><L><P><A><T><R><Q><D><P><P><S><S><R><D><S><V><G><L><R><K><V><L><G><D><K><F><S><S><L><R><R><K><L><S><A><R><K><L><A><R><A><E><S><A><P><R><P><W><D><G><E><E><S> | Probable zinc metalloprotease.<BOP> | Q400G9 |
Q6XYB7 | LBX2_HUMAN | Ladybird homeobox protein homolog 2 | Homo | <M><N><S><G><R><E><P><R><T><P><R><T><L><L><S><I><A><D><I><L><A><P><R><M><V><P><R><A><P><S><A><P><Q><L><P><E><S><G><P><G><P><T><S><P><L><C><A><L><E><E><L><T><S><K><T><F><R><G><L><D><A><R><A><L><Q><P><S><E><G><R><A><G><P><D><A><L><G><P><G><P><F><G><R><K><R><R><K><S><R><T><A><F><T><A><Q><Q><V><L><E><L><E><R><R><F><V><F><Q><K><Y><L><A><P><S><E><R><D><G><L><A><T><R><L><G><L><A><N><A><Q><V><V><T><W><F><Q><N><R><R><A><K><L><K><R><D><V><E><E><M><R><A><D><V><A><S><L><R><A><L><S><P><E><V><L><C><S><L><A><L><P><E><G><A><P><D><P><G><L><C><L><G><P><A><G><P><D><S><R><P><H><L><S><D><E><E><I><Q><V><D><D> | Transcription factor.<BOP> | Q6XYB7 |
P19971 | TYPH_HUMAN | TdRPase | Homo | <M><A><A><L><M><T><P><G><T><G><A><P><P><A><P><G><D><F><S><G><E><G><S><Q><G><L><P><D><P><S><P><E><P><K><Q><L><P><E><L><I><R><M><K><R><D><G><G><R><L><S><E><A><D><I><R><G><F><V><A><A><V><V><N><G><S><A><Q><G><A><Q><I><G><A><M><L><M><A><I><R><L><R><G><M><D><L><E><E><T><S><V><L><T><Q><A><L><A><Q><S><G><Q><Q><L><E><W><P><E><A><W><R><Q><Q><L><V><D><K><H><S><T><G><G><V><G><D><K><V><S><L><V><L><A><P><A><L><A><A><C><G><C><K><V><P><M><I><S><G><R><G><L><G><H><T><G><G><T><L><D><K><L><E><S><I><P><G><F><N><V><I><Q><S><P><E><Q><M><Q><V><L><L><D><Q><A><G><C><C><I><V><G><Q><S><E><Q><L><V><P><A><D><G><I><L><Y><A><A><R><D><V><T><A><T><V><D><S><L><P><L><I><T><A><S><I><L><S><K><K><L><V><E><G><L><S><A><L><V><V><D><V><K><F><G><G><A><A><V><F><P><N><Q><E><Q><A><R><E><L><A><K><T><L><V><G><V><G><A><S><L><G><L><R><V><A><A><A><L><T><A><M><D><K><P><L><G><R><C><V><G><H><A><L><E><V><E><E><A><L><L><C><M><D><G><A><G><P><P><D><L><R><D><L><V><T><T><L><G><G><A><L><L><W><L><S><G><H><A><G><T><Q><A><Q><G><A><A><R><V><A><A><A><L><D><D><G><S><A><L><G><R><F><E><R><M><L><A><A><Q><G><V><D><P><G><L><A><R><A><L><C><S><G><S><P><A><E><R><R><Q><L><L><P><R><A><R><E><Q><E><E><L><L><A><P><A><D><G><T><V><E><L><V><R><A><L><P><L><A><L><V><L><H><E><L><G><A><G><R><S><R><A><G><E><P><L><R><L><G><V><G><A><E><L><L><V><D><V><G><Q><R><L><R><R><G><T><P><W><L><R><V><H><R><D><G><P><A><L><S><G><P><Q><S><R><A><L><Q><E><A><L><V><L><S><D><R><A><P><F><A><A><P><S><P><F><A><E><L><V><L><P><P><Q><Q> | Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.<BOP> | P19971 |
P02689 | MYP2_HUMAN | Peripheral myelin protein 2 | Homo | <M><S><N><K><F><L><G><T><W><K><L><V><S><S><E><N><F><D><D><Y><M><K><A><L><G><V><G><L><A><T><R><K><L><G><N><L><A><K><P><T><V><I><I><S><K><K><G><D><I><I><T><I><R><T><E><S><T><F><K><N><T><E><I><S><F><K><L><G><Q><E><F><E><E><T><T><A><D><N><R><K><T><K><S><I><V><T><L><Q><R><G><S><L><N><Q><V><Q><R><W><D><G><K><E><T><T><I><K><R><K><L><V><N><G><K><M><V><A><E><C><K><M><K><G><V><V><C><T><R><I><Y><E><K><V> | May play a role in lipid transport protein in Schwann cells. May bind cholesterol.<BOP> | P02689 |
P51124 | GRAM_HUMAN | Natural killer cell granular protease | Homo | <M><E><A><C><V><S><S><L><L><V><L><A><L><G><A><L><S><V><G><S><S><F><G><T><Q><I><I><G><G><R><E><V><I><P><H><S><R><P><Y><M><A><S><L><Q><R><N><G><S><H><L><C><G><G><V><L><V><H><P><K><W><V><L><T><A><A><H><C><L><A><Q><R><M><A><Q><L><R><L><V><L><G><L><H><T><L><D><S><P><G><L><T><F><H><I><K><A><A><I><Q><H><P><R><Y><K><P><V><P><A><L><E><N><D><L><A><L><L><Q><L><D><G><K><V><K><P><S><R><T><I><R><P><L><A><L><P><S><K><R><Q><V><V><A><A><G><T><R><C><S><M><A><G><W><G><L><T><H><Q><G><G><R><L><S><R><V><L><R><E><L><D><L><Q><V><L><D><T><R><M><C><N><N><S><R><F><W><N><G><S><L><S><P><S><M><V><C><L><A><A><D><S><K><D><Q><A><P><C><K><G><D><S><G><G><P><L><V><C><G><K><G><R><V><L><A><R><V><L><S><F><S><S><R><V><C><T><D><I><F><K><P><P><V><A><T><A><V><A><P><Y><V><S><W><I><R><K><V><T><G><R><S><A> | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<BOP> | P51124 |
P46092 | CCR10_HUMAN | G-protein coupled receptor 2 | Homo | <M><G><T><E><A><T><E><Q><V><S><W><G><H><Y><S><G><D><E><E><D><A><Y><S><A><E><P><L><P><E><L><C><Y><K><A><D><V><Q><A><F><S><R><A><F><Q><P><S><V><S><L><T><V><A><A><L><G><L><A><G><N><G><L><V><L><A><T><H><L><A><A><R><R><A><A><R><S><P><T><S><A><H><L><L><Q><L><A><L><A><D><L><L><L><A><L><T><L><P><F><A><A><A><G><A><L><Q><G><W><S><L><G><S><A><T><C><R><T><I><S><G><L><Y><S><A><S><F><H><A><G><F><L><F><L><A><C><I><S><A><D><R><Y><V><A><I><A><R><A><L><P><A><G><P><R><P><S><T><P><G><R><A><H><L><V><S><V><I><V><W><L><L><S><L><L><L><A><L><P><A><L><L><F><S><Q><D><G><Q><R><E><G><Q><R><R><C><R><L><I><F><P><E><G><L><T><Q><T><V><K><G><A><S><A><V><A><Q><V><A><L><G><F><A><L><P><L><G><V><M><V><A><C><Y><A><L><L><G><R><T><L><L><A><A><R><G><P><E><R><R><R><A><L><R><V><V><V><A><L><V><A><A><F><V><V><L><Q><L><P><Y><S><L><A><L><L><L><D><T><A><D><L><L><A><A><R><E><R><S><C><P><A><S><K><R><K><D><V><A><L><L><V><T><S><G><L><A><L><A><R><C><G><L><N><P><V><L><Y><A><F><L><G><L><R><F><R><Q><D><L><R><R><L><L><R><G><G><S><C><P><S><G><P><Q><P><R><R><G><C><P><R><R><P><R><L><S><S><C><S><A><P><T><E><T><H><S><L><S><W><D><N> | Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.<BOP> | P46092 |
Q9BY32 | ITPA_HUMAN | Putative oncogene protein hlc14-06-p | Homo | <M><A><A><S><L><V><G><K><K><I><V><F><V><T><G><N><A><K><K><L><E><E><V><V><Q><I><L><G><D><K><F><P><C><T><L><V><A><Q><K><I><D><L><P><E><Y><Q><G><E><P><D><E><I><S><I><Q><K><C><Q><E><A><V><R><Q><V><Q><G><P><V><L><V><E><D><T><C><L><C><F><N><A><L><G><G><L><P><G><P><Y><I><K><W><F><L><E><K><L><K><P><E><G><L><H><Q><L><L><A><G><F><E><D><K><S><A><Y><A><L><C><T><F><A><L><S><T><G><D><P><S><Q><P><V><R><L><F><R><G><R><T><S><G><R><I><V><A><P><R><G><C><Q><D><F><G><W><D><P><C><F><Q><P><D><G><Y><E><Q><T><Y><A><E><M><P><K><A><E><K><N><A><V><S><H><R><F><R><A><L><L><E><L><Q><E><Y><F><G><S><L><A><A> | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.<BOP> | Q9BY32 |
A0PJE2 | DHR12_HUMAN | Short-chain dehydrogenase/reductase family 40C member 1 | Homo | <M><S><L><Y><R><S><V><V><W><F><A><K><G><L><R><E><Y><T><K><S><G><Y><E><S><A><C><K><D><F><V><P><H><D><L><E><V><Q><I><P><G><R><V><F><L><V><T><G><G><N><S><G><I><G><K><A><T><A><L><E><I><A><K><R><G><G><T><V><H><L><V><C><R><D><Q><A><P><A><E><D><A><R><G><E><I><I><R><E><S><G><N><Q><N><I><F><L><H><I><V><D><L><S><D><P><K><Q><I><W><K><F><V><E><N><F><K><Q><E><H><K><L><H><V><L><I><N><N><A><G><C><M><V><N><K><R><E><L><T><E><D><G><L><E><K><N><F><A><A><N><T><L><G><V><Y><I><L><T><T><G><L><I><P><V><L><E><K><E><H><D><P><R><V><I><T><V><S><S><G><G><M><L><V><Q><K><L><N><T><N><D><L><Q><S><E><R><T><P><F><D><G><T><M><V><Y><A><Q><N><K><R><Q><Q><V><V><L><T><E><R><W><A><Q><G><H><P><A><I><H><F><S><S><M><H><P><G><W><A><D><T><P><G><V><R><Q><A><M><P><G><F><H><A><R><F><G><D><R><L><R><S><E><A><Q><G><A><D><T><M><L><W><L><A><L><S><S><A><A><A><A><Q><P><S><G><R><F><F><Q><D><R><K><P><V><S><T><H><L><P><L><A><T><A><S><S><S><P><A><E><E><E><K><L><I><E><I><L><E><Q><L><A><Q><T><F><K> | Putative oxidoreductase.<BOP> | A0PJE2 |
Q7Z7B8 | DB128_HUMAN | Defensin, beta 128 | Homo | <M><K><L><F><L><V><L><I><I><L><L><F><E><V><L><T><D><G><A><R><L><K><K><C><F><N><K><V><T><G><Y><C><R><K><K><C><K><V><G><E><R><Y><E><I><G><C><L><S><G><K><L><C><C><A><N><D><E><E><E><K><K><H><V><S><F><K><K><P><H><Q><H><S><G><E><K><L><S><V><L><Q><D><Y><I><I><L><P><T><I><T><I><F><T><V> | Has antibacterial activity.<BOP> | Q7Z7B8 |
Q6P531 | GGT6_HUMAN | Glutathione hydrolase 6 light chain | Homo | <M><E><R><A><E><E><P><V><V><Y><Q><K><L><L><P><W><E><P><S><L><E><S><E><E><E><V><E><E><E><E><T><S><E><A><L><V><L><N><P><R><R><H><Q><D><S><S><R><N><K><A><G><G><L><P><G><T><W><A><R><V><V><A><A><L><L><L><L><A><V><G><C><S><L><A><V><R><Q><L><Q><N><Q><G><R><S><T><G><S><L><G><S><V><A><P><P><P><G><G><H><S><H><G><P><G><V><Y><H><H><G><A><I><I><S><P><A><G><R><E><L><L><V><A><G><G><N><V><V><D><A><G><V><G><A><A><L><C><L><A><V><V><H><P><H><A><T><G><L><G><A><M><F><W><G><L><F><H><D><S><S><S><G><N><S><T><A><L><T><S><G><P><A><Q><T><L><A><P><G><L><G><L><P><A><A><L><P><T><L><H><L><L><H><A><R><F><G><R><L><P><W><P><R><L><L><V><G><P><T><T><L><A><Q><E><G><F><L><V><D><T><P><L><A><R><A><L><V><A><R><G><T><E><G><L><C><P><L><L><C><H><A><D><G><T><P><L><G><A><G><A><R><A><T><N><P><Q><L><A><A><V><L><R><S><A><A><L><A><P><T><S><D><L><A><G><D><A><L><L><S><L><L><A><G><D><L><G><V><E><V><P><S><A><V><P><R><P><T><L><E><P><A><E><Q><L><P><V><P><Q><G><I><L><F><T><T><P><S><P><S><A><G><P><E><L><L><A><L><L><E><A><A><L><R><S><G><A><P><I><P><D><P><C><P><P><F><L><Q><T><A><V><S><P><E><S><S><A><L><A><A><V><D><S><S><G><S><V><L><L><L><T><S><S><L><N><C><S><F><G><S><A><H><L><S><P><S><T><G><V><L><L><S><N><L><V><A><K><S><T><T><S><A><W><A><C><P><L><I><L><R><G><S><L><D><D><T><E><A><D><V><L><G><L><V><A><S><G><T><P><D><V><A><R><A><M><T><H><T><L><L><R><H><L><A><A><R><P><P><T><Q><A><Q><H><Q><H><Q><G><Q><Q><E><P><T><E><H><P><S><T><C><G><Q><G><T><L><L><Q><V><A><A><H><T><E><H><A><H><V><S><S><V><P><H><A><C><C><P><F><Q><G><F> | Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.<BOP> | Q6P531 |
O43548 | TGM5_HUMAN | Transglutaminase-5 | Homo | <M><A><Q><G><L><E><V><A><L><T><D><L><Q><S><S><R><N><N><V><R><H><H><T><E><E><I><T><V><D><H><L><L><V><R><R><G><Q><A><F><N><L><T><L><Y><F><R><N><R><S><F><Q><P><G><L><D><N><I><I><F><V><V><E><T><G><P><L><P><D><L><A><L><G><T><R><A><V><F><S><L><A><R><H><H><S><P><S><P><W><I><A><W><L><E><T><N><G><A><T><S><T><E><V><S><L><C><A><P><P><T><A><A><V><G><R><Y><L><L><K><I><H><I><D><S><F><Q><G><S><V><T><A><Y><Q><L><G><E><F><I><L><L><F><N><P><W><C><P><E><D><A><V><Y><L><D><S><E><P><Q><R><Q><E><Y><V><M><N><D><Y><G><F><I><Y><Q><G><S><K><N><W><I><R><P><C><P><W><N><Y><G><Q><F><E><D><K><I><I><D><I><C><L><K><L><L><D><K><S><L><H><F><Q><T><D><P><A><T><D><C><A><L><R><G><S><P><V><Y><V><S><R><V><V><C><A><M><I><N><S><N><D><D><N><G><V><L><N><G><N><W><S><E><N><Y><T><D><G><A><N><P><A><E><W><T><G><S><V><A><I><L><K><Q><W><N><A><T><G><C><Q><P><V><R><Y><G><Q><C><W><V><F><A><A><V><M><C><T><V><M><R><C><L><G><I><P><T><R><V><I><T><N><F><D><S><G><H><D><T><D><G><N><L><I><I><D><E><Y><Y><D><N><T><G><R><I><L><G><N><K><K><K><D><T><I><W><N><F><H><V><W><N><E><C><W><M><A><R><K><D><L><P><P><A><Y><G><G><W><Q><V><L><D><A><T><P><Q><E><M><S><N><G><V><Y><C><C><G><P><A><S><V><R><A><I><K><E><G><E><V><D><L><N><Y><D><T><P><F><V><F><S><M><V><N><A><D><C><M><S><W><L><V><Q><G><G><K><E><Q><K><L><H><Q><D><T><S><S><V><G><N><F><I><S><T><K><S><I><Q><S><D><E><R><D><D><I><T><E><N><Y><K><Y><E><E><G><S><L><Q><E><R><Q><V><F><L><K><A><L><Q><K><L><K><A><R><S><F><H><G><S><Q><R><G><A><E><L><Q><P><S><R><P><T><S><L><S><Q><D><S><P><R><S><L><H><T><P><S><L><R><P><S><D><V><V><Q><V><S><L><K><F><K><L><L><D><P><P><N><M><G><Q><D><I><C><F><V><L><L><A><L><N><M><S><S><Q><F><K><D><L><K><V><N><L><S><A><Q><S><L><L><H><D><G><S><P><L><S><P><F><W><Q><D><T><A><F><I><T><L><S><P><K><E><A><K><T><Y><P><C><K><I><S><Y><S><Q><Y><S><Q><Y><L><S><T><D><K><L><I><R><I><S><A><L><G><E><E><K><S><S><P><E><K><I><L><V><N><K><I><I><T><L><S><Y><P><S><I><T><I><N><V><L><G><A><A><V><V><N><Q><P><L><S><I><Q><V><I><F><S><N><P><L><S><E><Q><V><E><D><C><V><L><T><V><E><G><S><G><L><F><K><K><Q><Q><K><V><F><L><G><V><L><K><P><Q><H><Q><A><S><I><I><L><E><T><V><P><F><K><S><G><Q><R><Q><I><Q><A><N><M><R><S><N><K><F><K><D><I><K><G><Y><R><N><V><Y><V><D><F><A><L> | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.<BOP> | O43548 |
Q2YD98 | UVSSA_HUMAN | UV-stimulated scaffold protein A | Homo | <M><D><Q><K><L><S><K><L><V><E><E><L><T><T><S><G><E><P><R><L><N><P><E><K><M><K><E><L><K><K><I><C><K><S><S><E><E><Q><L><S><R><A><Y><R><L><L><I><A><Q><L><T><Q><E><H><A><E><I><R><L><S><A><F><Q><I><V><E><E><L><F><V><R><S><H><Q><F><R><M><L><V><V><S><N><F><Q><E><F><L><E><L><T><L><G><T><D><P><A><Q><P><L><P><P><P><R><E><A><A><Q><R><L><R><Q><A><T><T><R><A><V><E><G><W><N><E><K><F><G><E><A><Y><K><K><L><A><L><G><Y><H><F><L><R><H><N><K><K><V><D><F><Q><D><T><N><A><R><S><L><A><E><R><K><R><E><E><E><K><Q><K><H><L><D><K><I><Y><Q><E><R><A><S><Q><A><E><R><E><M><Q><E><M><S><G><E><I><E><S><C><L><T><E><V><E><S><C><F><R><L><L><V><P><F><D><F><D><P><N><P><E><T><E><S><L><G><M><A><S><G><M><S><D><A><L><R><S><S><C><A><G><Q><V><G><P><C><R><S><G><T><P><D><P><R><D><G><E><Q><P><C><C><S><R><D><L><P><A><S><A><G><H><P><R><A><G><G><G><A><Q><P><S><Q><T><A><T><G><D><P><S><D><E><D><E><D><S><D><L><E><E><F><V><R><S><H><G><L><G><S><H><K><Y><T><L><D><V><E><L><C><S><E><G><L><K><V><Q><E><N><E><D><N><L><A><L><I><H><A><A><R><D><T><L><K><L><I><R><N><K><F><L><P><A><V><C><S><W><I><Q><R><F><T><R><V><G><T><H><G><G><C><L><K><R><A><I><D><L><K><A><E><L><E><L><V><L><R><K><Y><K><E><L><D><I><E><P><E><G><G><E><R><R><R><T><E><A><L><G><D><A><E><E><D><E><D><D><E><D><F><V><E><V><P><E><K><E><G><Y><E><P><H><I><P><D><H><L><R><P><E><Y><G><L><E><A><A><P><E><K><D><T><V><V><R><C><L><R><T><R><T><R><M><D><E><E><V><S><D><P><T><S><A><A><A><Q><L><R><Q><L><R><D><H><L><P><P><P><S><S><A><S><P><S><R><A><L><P><E><P><Q><E><A><Q><K><L><A><A><E><R><A><R><A><P><V><V><P><Y><G><V><D><L><H><Y><W><G><Q><E><L><P><T><A><G><K><I><V><K><S><D><S><Q><H><R><F><W><K><P><S><E><V><E><E><E><V><V><N><A><D><I><S><E><M><L><R><S><R><H><I><T><F><A><G><K><F><E><P><V><Q><H><W><C><R><A><P><R><P><D><G><R><L><C><E><R><Q><D><R><L><K><C><P><F><H><G><K><I><V><P><R><D><D><E><G><R><P><L><D><P><E><D><R><A><R><E><Q><R><R><Q><L><Q><K><Q><E><R><P><E><W><Q><D><P><E><L><M><R><D><V><E><A><A><T><G><Q><D><L><G><S><S><R><Y><S><G><K><G><R><G><K><K><R><R><Y><P><S><L><T><N><L><K><A><Q><A><D><T><A><R><A><R><I><G><R><K><V><F><A><K><A><A><V><R><R><V><V><A><A><M><N><R><M><D><Q><K><K><H><E><K><F><S><N><Q><F><N><Y><A><L><N> | Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.<BOP> | Q2YD98 |
Q9BVV7 | TIM21_HUMAN | TIM21-like protein, mitochondrial | Homo | <M><I><C><T><F><L><R><A><V><Q><Y><T><E><K><L><H><R><S><S><A><K><R><L><L><L><P><Y><I><V><L><N><K><A><C><L><K><T><E><P><S><L><R><C><G><L><Q><Y><Q><K><K><T><L><R><P><R><C><I><L><G><V><T><Q><K><T><I><W><T><Q><G><P><S><P><R><K><A><K><E><D><G><S><K><Q><V><S><V><H><R><S><Q><R><G><G><T><A><V><P><T><S><Q><K><V><K><E><A><G><R><D><F><T><Y><L><I><V><V><L><F><G><I><S><I><T><G><G><L><F><Y><T><I><F><K><E><L><F><S><S><S><S><P><S><K><I><Y><G><R><A><L><E><K><C><R><S><H><P><E><V><I><G><V><F><G><E><S><V><K><G><Y><G><E><V><T><R><R><G><R><R><Q><H><V><R><F><T><E><Y><V><K><D><G><L><K><H><T><C><V><K><F><Y><I><E><G><S><E><P><G><K><Q><G><T><V><Y><A><Q><V><K><E><N><P><G><S><G><E><Y><D><F><R><Y><I><F><V><E><I><E><S><Y><P><R><R><T><I><I><I><E><D><N><R><S><Q><D><D> | Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.<BOP> | Q9BVV7 |
Q9BTX3 | TM208_HUMAN | Transmembrane protein 208 | Homo | <M><A><P><K><G><K><V><G><T><R><G><K><K><Q><I><F><E><E><N><R><E><T><L><K><F><Y><L><R><I><I><L><G><A><N><A><I><Y><C><L><V><T><L><V><F><F><Y><S><S><A><S><F><W><A><W><L><A><L><G><F><S><L><A><V><Y><G><A><S><Y><H><S><M><S><S><M><A><R><A><A><F><S><E><D><G><A><L><M><D><G><G><M><D><L><N><M><E><Q><G><M><A><E><H><L><K><D><V><I><L><L><T><A><I><V><Q><V><L><S><C><F><S><L><Y><V><W><S><F><W><L><L><A><P><G><R><A><L><Y><L><L><W><V><N><V><L><G><P><W><F><T><A><D><S><G><T><P><A><P><E><H><N><E><K><R><Q><R><R><Q><E><R><R><Q><M><K><R><L> | May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.<BOP> | Q9BTX3 |
P04155 | TFF1_HUMAN | Protein pS2 | Homo | <M><A><T><M><E><N><K><V><I><C><A><L><V><L><V><S><M><L><A><L><G><T><L><A><E><A><Q><T><E><T><C><T><V><A><P><R><E><R><Q><N><C><G><F><P><G><V><T><P><S><Q><C><A><N><K><G><C><C><F><D><D><T><V><R><G><V><P><W><C><F><Y><P><N><T><I><D><V><P><P><E><E><E><C><E><F> | Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.<BOP> | P04155 |
Q6IF36 | O8G2P_HUMAN | Olfactory receptor TPCR120 | Homo | <M><V><F><L><S><S><V><E><T><D><Q><R><K><M><S><A><G><N><H><S><S><V><T><E><F><I><L><A><G><L><S><E><Q><P><E><L><Q><L><R><L><F><L><L><F><L><G><I><Y><V><V><T><V><V><G><N><L><S><M><I><T><L><I><G><L><S><S><H><L><H><T><P><M><Y><Y><F><L><S><G><L><S><F><I><D><L><C><H><S><T><I><I><T><P><K><M><L><V><N><F><V><T><E><K><N><I><I><S><Y><P><E><C><M><T><Q><L><Y><F><F><L><I><F><A><I><A><E><C><H><M><L><A><V><T><A><Y><D><R><Y><V><A><I><C><S><P><L><L><Y><N><V><I><M><S><Y><H><H><C><F><W><L><T><V><G><V><Y><V><L><G><I><L><G><S><T><I><H><T><G><F><M><L><R><L><F><L><C><K><T><N><V><I><N><H><Y><F><C><D><L><F><P><L><L><G><L><S><C><S><S><T><Y><I><N><E><L><L><V><L><V><L><S><A><F><N><I><L><T><P><A><L><T><I><L><A><S><Y><I><F><I><I><A><S><I><L><R><I><R><S><T><E><G><R><S><K><A><F><S><T><C><S><S><H><I><L><A><V><A><V><F><F><G><S><A><A><F><M><Y><L><Q><P><S><S><V><S><S><M><D><Q><R><K><V><S><S><V><F><Y><T><T><I><V><P><M><L><N><P><Q><S><I><A> | Odorant receptor.<BOP> | Q6IF36 |
Q96AY2 | EME1_HUMAN | MMS4 homolog | Homo | <M><A><L><K><K><S><S><P><S><L><D><S><G><D><S><D><S><E><E><L><P><T><F><A><F><L><K><K><E><P><S><S><T><K><R><R><Q><P><E><R><E><E><K><I><V><V><V><D><I><S><D><C><E><A><S><C><P><P><A><P><E><L><F><S><P><P><V><P><E><I><A><E><T><V><T><Q><T><Q><P><V><R><L><L><S><S><E><S><E><D><E><E><E><F><I><P><L><A><Q><R><L><T><C><K><F><L><T><H><K><Q><L><S><P><E><D><S><S><S><P><V><K><S><V><L><D><H><Q><N><N><E><G><A><S><C><D><W><K><K><P><F><P><K><I><P><E><V><P><L><H><D><T><P><E><R><S><A><A><D><N><K><D><L><I><L><D><P><C><C><Q><L><P><A><Y><L><S><T><C><P><G><Q><S><S><S><L><A><V><T><K><T><N><S><D><I><L><P><P><Q><K><K><T><K><P><S><Q><K><V><Q><G><R><G><S><H><G><C><R><Q><Q><R><Q><A><R><Q><K><E><S><T><L><R><R><Q><E><R><K><N><A><A><L><V><T><R><M><K><A><Q><R><P><E><E><C><L><K><H><I><I><V><V><L><D><P><V><L><L><Q><M><E><G><G><G><Q><L><L><G><A><L><Q><T><M><E><C><R><C><V><I><E><A><Q><A><V><P><C><S><V><T><W><R><R><R><A><G><P><S><E><D><R><E><D><W><V><E><E><P><T><V><L><V><L><L><R><A><E><A><F><V><S><M><I><D><N><G><K><Q><G><S><L><D><S><T><M><K><G><K><E><T><L><Q><G><F><V><T><D><I><T><A><K><T><A><G><K><A><L><S><L><V><I><V><D><Q><E><K><C><F><S><A><Q><N><P><P><R><R><G><K><Q><G><A><N><K><Q><T><K><K><Q><Q><Q><R><Q><P><E><A><S><I><G><S><M><V><S><R><V><D><A><E><E><A><L><V><D><L><Q><L><H><T><E><A><Q><A><Q><I><V><Q><S><W><K><E><L><A><D><F><T><C><A><F><T><K><A><V><A><E><A><P><F><K><K><L><R><D><E><T><T><F><S><F><C><L><E><S><D><W><A><G><G><V><K><V><D><L><A><G><R><G><L><A><L><V><W><R><R><Q><I><Q><Q><L><N><R><V><S><L><E><M><A><S><A><V><V><N><A><Y><P><S><P><Q><L><L><V><Q><A><Y><Q><Q><C><F><S><D><K><E><R><Q><N><L><L><A><D><I><Q><V><R><R><G><E><G><V><T><S><T><S><R><R><I><G><P><E><L><S><R><R><I><Y><L><Q><M><T><T><L><Q><P><H><L><S><L><D><S><A><D> | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<BOP> | Q96AY2 |
Q9Y226 | S22AD_HUMAN | Organic cation transporter-like 3 | Homo | <M><A><Q><F><V><Q><V><L><A><E><I><G><D><F><G><R><F><Q><I><Q><L><L><I><L><L><C><V><L><N><F><L><S><P><F><Y><F><F><A><H><V><F><M><V><L><D><E><P><H><H><C><A><V><A><W><V><K><N><H><T><F><N><L><S><A><A><E><Q><L><V><L><S><V><P><L><D><T><A><G><H><P><E><P><C><L><M><F><R><P><P><P><A><N><A><S><L><Q><D><I><L><S><H><R><F><N><E><T><Q><P><C><D><M><G><W><E><Y><P><E><N><R><L><P><S><L><K><N><E><F><N><L><V><C><D><R><K><H><L><K><D><T><T><Q><S><V><F><M><A><G><L><L><V><G><T><L><M><F><G><P><L><C><D><R><I><G><R><K><A><T><I><L><A><Q><L><L><L><F><T><L><I><G><L><A><T><A><F><V><P><S><F><E><L><Y><M><A><L><R><F><A><V><A><T><A><V><A><G><L><S><F><S><N><V><T><L><L><T><E><W><V><G><P><S><W><R><T><Q><A><V><V><L><A><Q><C><N><F><S><L><G><Q><M><V><L><A><G><L><A><Y><G><F><R><N><W><R><L><L><Q><I><T><G><T><A><P><G><L><L><L><F><F><Y><F><W><A><L><P><E><S><A><R><W><L><L><T><R><G><R><M><D><E><A><I><Q><L><I><Q><K><A><A><S><V><N><R><R><K><L><S><P><E><L><M><N><Q><L><V><P><E><K><T><G><P><S><G><N><A><L><D><L><F><R><H><P><Q><L><R><K><V><T><L><I><I><F><C><V><W><F><V><D><S><L><G><Y><Y><G><L><S><L><Q><V><G><D><F><G><L><D><V><Y><L><T><Q><L><I><F><G><A><V><E><V><P><A><R><C><S><S><I><F><M><M><Q><R><F><G><R><K><W><S><Q><L><G><T><L><V><L><G><G><L><M><C><I><I><I><I><F><I><P><A><D><L><P><V><V><V><T><M><L><A><V><V><G><K><M><A><T><A><A><A><F><T><I><S><Y><V><Y><S><A><E><L><F><P><T><I><L><R><Q><T><G><M><G><L><V><G><I><F><S><R><I><G><G><I><L><T><P><L><V><I><L><L><G><E><Y><H><A><A><L><P><M><L><I><Y><G><S><L><P><I><V><A><G><L><L><C><T><L><L><P><E><T><H><G><Q><G><L><K><D><T><L><Q><D><L><E><L><G><P><H><P><R><S><P><K><S><V><P><S><E><K><E><T><E><A><K><G><R><T><S><S><P><G><V><A><F><V><S><S><T><Y><F> | Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions . Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption . Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption . Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate . Urate and orotate transports are Cl(-)-dependent . Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).<BOP> | Q9Y226 |
Q96R09 | OR5B2_HUMAN | Olfactory receptor OR11-240 | Homo | <M><E><N><C><T><E><V><T><K><F><I><L><L><G><L><T><S><V><P><E><L><Q><I><P><L><F><I><L><F><T><F><I><Y><L><L><T><L><C><G><N><L><G><M><M><L><L><I><L><M><D><S><C><L><H><T><P><M><Y><F><F><L><S><N><L><S><L><V><D><F><G><Y><S><S><A><V><T><P><K><V><M><A><G><F><L><R><G><D><K><V><I><S><Y><N><A><C><A><V><Q><M><F><F><F><V><A><L><A><T><V><E><N><Y><L><L><A><S><M><A><Y><D><R><Y><A><A><V><C><K><P><L><H><Y><T><T><T><M><T><A><S><V><G><A><C><L><A><L><G><S><Y><V><C><G><F><L><N><A><S><F><H><I><G><G><I><F><S><L><S><F><C><K><S><N><L><V><H><H><F><F><C><D><V><P><A><V><M><A><L><S><C><S><D><K><H><T><S><E><V><I><L><V><F><M><S><S><F><N><I><F><F><V><L><L><V><I><F><I><S><Y><L><F><I><F><I><T><I><L><K><M><H><S><A><K><G><H><Q><K><A><L><S><T><C><A><S><H><F><T><A><V><S><V><F><Y><G><T><V><I><F><I><Y><L><Q><P><S><S><S><H><S><M><D><T><D><K><M><A><S><V><F><Y><A><M><I><I><P><M><L><N><P><V><V><Y><S><L><R><N><R><E><V><Q><N><A><F><K><K><V><L><R><R><Q><K><F><L> | Odorant receptor.<BOP> | Q96R09 |
O95158 | NXPH4_HUMAN | Neurexophilin-4 | Homo | <M><R><L><L><P><E><W><F><L><L><L><F><G><P><W><L><L><R><K><A><V><S><A><Q><I><P><E><S><G><R><P><Q><Y><L><G><L><R><P><A><A><A><G><A><G><A><P><G><Q><Q><L><P><E><P><R><S><S><D><G><L><G><V><G><R><A><W><S><W><A><W><P><T><N><H><T><G><A><L><A><R><A><G><A><A><G><A><L><P><A><Q><R><T><K><R><K><P><S><I><K><A><A><R><A><K><K><I><F><G><W><G><D><F><Y><F><R><V><H><T><L><K><F><S><L><L><V><T><G><K><I><V><D><H><V><N><G><T><F><S><V><Y><F><R><H><N><S><S><S><L><G><N><L><S><V><S><I><V><P><P><S><K><R><V><E><F><G><G><V><W><L><P><G><P><V><P><H><P><L><Q><S><T><L><A><L><E><G><V><L><P><G><L><G><P><P><L><G><M><A><A><A><A><A><G><P><G><L><G><G><S><L><G><G><A><L><A><G><P><L><G><G><A><L><G><V><P><G><A><K><E><S><R><A><F><N><C><H><V><E><Y><E><K><T><N><R><A><R><K><H><R><P><C><L><Y><D><P><S><Q><V><C><F><T><E><H><T><Q><S><Q><A><A><W><L><C><A><K><P><F><K><V><I><C><I><F><V><S><F><L><S><F><D><Y><K><L><V><Q><K><V><C><P><D><Y><N><F><Q><S><E><H><P><Y><F><G> | May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.<BOP> | O95158 |
Q08AE8 | SPIR1_HUMAN | Protein spire homolog 1 | Homo | <M><A><Q><A><A><G><P><A><G><G><G><E><P><R><T><E><A><V><G><G><E><G><P><R><E><P><G><A><A><G><G><A><A><G><G><S><R><D><A><L><S><L><E><E><I><L><R><L><Y><N><Q><P><I><N><E><E><Q><A><W><A><V><C><Y><Q><C><C><G><S><L><R><A><A><A><R><R><R><Q><P><R><H><R><V><R><S><A><A><Q><I><R><V><W><R><D><G><A><V><T><L><A><P><A><A><D><D><A><G><E><P><P><P><V><A><G><K><L><G><Y><S><Q><C><M><E><T><E><V><I><E><S><L><G><I><I><I><Y><K><A><L><D><Y><G><L><K><E><N><E><E><R><E><L><S><P><P><L><E><Q><L><I><D><H><M><A><N><T><V><E><A><D><G><S><N><D><E><G><Y><E><A><A><E><E><G><L><G><D><E><D><E><K><R><K><I><S><A><I><R><S><Y><R><D><V><M><K><L><C><A><A><H><L><P><T><E><S><D><A><P><N><H><Y><Q><A><V><C><R><A><L><F><A><E><T><M><E><L><H><T><F><L><T><K><I><K><S><A><K><E><N><L><K><K><I><Q><E><M><E><K><S><D><E><S><S><T><D><L><E><E><L><K><N><A><D><W><A><R><F><W><V><Q><V><M><R><D><L><R><N><G><V><K><L><K><K><V><Q><E><R><Q><Y><N><P><L><P><I><E><Y><Q><L><T><P><Y><E><M><L><M><D><D><I><R><C><K><R><Y><T><L><R><K><V><M><V><N><G><D><I><P><P><R><L><K><K><S><A><H><E><I><I><L><D><F><I><R><S><R><P><P><L><N><P><V><S><A><R><K><L><K><P><T><P><P><R><P><R><S><L><H><E><R><I><L><E><E><I><K><A><E><R><K><L><R><P><V><S><P><E><E><I><R><R><S><R><L><A><M><R><P><L><S><M><S><Y><S><F><D><L><S><D><V><T><T><P><E><S><T><K><N><L><V><E><S><S><M><V><N><G><G><L><T><S><Q><T><K><E><N><G><L><S><T><S><Q><Q><V><P><A><Q><R><K><K><L><L><R><A><P><T><L><A><E><L><D><S><S><E><S><E><E><E><T><L><H><K><S><T><S><S><S><S><V><S><P><S><F><P><E><E><P><V><L><E><A><V><S><T><R><K><K><P><P><K><F><L><P><I><S><S><T><P><Q><P><E><R><R><Q><P><P><Q><R><R><H><S><I><E><K><E><T><P><T><N><V><R><Q><F><L><P><P><S><R><Q><S><S><R><S><L><E><E><F><C><Y><P><V><E><C><L><A><L><T><V><E><E><V><M><H><I><R><Q><V><L><V><K><A><E><L><E><K><Y><Q><Q><Y><K><D><I><Y><T><A><L><K><K><G><K><L><C><F><C><C><R><T><R><R><F><S><F><F><T><W><S><Y><T><C><Q><F><C><K><R><P><V><C><S><Q><C><C><K><K><M><R><L><P><S><K><P><Y><S><T><L><P><I><F><S><L><G><P><S><A><L><Q><R><G><E><S><S><M><R><S><E><K><P><S><T><A><H><H><R><P><L><R><S><I><A><R><F><S><S><K><S><K><S><M><D><K><S><D><E><E><L><Q><F><P><K><E><L><M><E><D><W><S><T><M><E><V><C><V><D><C><K><K><F><I><S><E><I><I><S><S><S><R><R><S><L><V><L><A><N><K><R><A><R><L><K><R><K><T><Q><S><F><Y><M><S><S><P><G><P><S><E><Y><C><P><S><E><R><T><I><S><E><I> | Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . In addition, promotes innate immune signaling downstream of dsRNA sensing . Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 .<BOP> | Q08AE8 |
P0C1H6 | H2BFM_HUMAN | Histone H2B.s | Homo | <M><A><A><A><S><A><M><A><E><A><S><S><E><T><T><S><E><E><G><Q><S><I><Q><E><P><K><E><A><N><S><T><K><A><Q><K><Q><K><R><R><G><C><R><G><S><R><R><R><H><A><N><R><R><G><D><S><F><G><D><S><F><T><P><Y><F><P><R><V><L><K><Q><V><H><Q><G><L><S><L><S><Q><E><A><V><S><V><M><D><S><M><I><H><D><I><L><D><R><I><A><T><E><A><G><Q><L><A><H><Y><T><K><R><V><T><I><T><S><R><D><I><Q><M><A><V><R><L><L><L><P><G><K><M><G><K><L><A><E><A><Q><G><T><N><A><A><L><R><T><S><L><C><A><I><W><Q><Q><R><K> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | P0C1H6 |
Q99583 | MNT_HUMAN | Protein ROX | Homo | <M><S><I><E><T><L><L><E><A><A><R><F><L><E><W><Q><A><Q><Q><Q><Q><R><A><R><E><E><Q><E><R><L><R><L><E><Q><E><R><E><Q><E><Q><K><K><A><N><S><L><A><R><L><A><H><T><L><P><V><E><E><P><R><M><E><A><P><P><L><P><L><S><P><P><A><P><P><P><A><P><P><P><P><L><A><T><P><A><P><L><T><V><I><P><I><P><V><V><T><N><S><P><Q><P><L><P><P><P><P><P><L><P><A><A><A><Q><P><L><P><L><A><P><R><Q><P><A><L><V><G><A><P><G><L><S><I><K><E><P><A><P><L><P><S><R><P><Q><V><P><T><P><A><P><L><L><P><D><S><K><A><T><I><P><P><N><G><S><P><K><P><L><Q><P><L><P><T><P><V><L><T><I><A><P><H><P><G><V><Q><P><Q><L><A><P><Q><Q><P><P><P><P><T><L><G><T><L><K><L><A><P><A><E><E><V><K><S><S><E><Q><K><K><R><P><G><G><I><G><T><R><E><V><H><N><K><L><E><K><N><R><R><A><H><L><K><E><C><F><E><T><L><K><R><N><I><P><N><V><D><D><K><K><T><S><N><L><S><V><L><R><T><A><L><R><Y><I><Q><S><L><K><R><K><E><K><E><Y><E><H><E><M><E><R><L><A><R><E><K><I><A><T><Q><Q><R><L><A><E><L><K><H><E><L><S><Q><W><M><D><V><L><E><I><D><R><V><L><R><Q><T><G><Q><P><E><D><D><Q><A><S><T><S><T><A><S><E><G><E><D><N><I><D><E><D><M><E><E><D><R><A><G><L><G><P><P><K><L><S><H><R><P><Q><P><E><L><L><K><S><T><L><P><P><P><S><T><T><P><A><P><L><P><P><H><P><H><P><H><P><H><S><V><A><L><P><P><A><H><L><P><V><Q><Q><Q><Q><P><Q><Q><K><T><P><L><P><A><P><P><P><P><P><A><A><P><A><Q><T><L><V><P><A><P><A><H><L><V><A><T><A><G><G><G><S><T><V><I><A><H><T><A><T><T><H><A><S><V><I><Q><T><V><N><H><V><L><Q><G><P><G><G><K><H><I><A><H><I><A><P><S><A><P><S><P><A><V><Q><L><A><P><A><T><P><P><I><G><H><I><T><V><H><P><A><T><L><N><H><V><A><H><L><G><S><Q><L><P><L><Y><P><Q><P><V><A><V><S><H><I><A><H><T><L><S><H><Q><Q><V><N><G><T><A><G><L><G><P><P><A><T><V><M><A><K><P><A><V><G><A><Q><V><V><H><H><P><Q><L><V><G><Q><T><V><L><N><P><V><T><M><V><T><M><P><S><F><P><V><S><T><L><K><L><A> | Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.<BOP> | Q99583 |
Q5SGD2 | PPM1L_HUMAN | Protein phosphatase 2C isoform epsilon | Homo | <M><I><E><D><T><M><T><L><L><S><L><L><G><R><I><M><R><Y><F><L><L><R><P><E><T><L><F><L><L><C><I><S><L><A><L><W><S><Y><F><F><H><T><D><E><V><K><T><I><V><K><S><S><R><D><A><V><K><M><V><K><G><K><V><A><E><I><M><Q><N><D><R><L><G><G><L><D><V><L><E><A><E><F><S><K><T><W><E><F><K><N><H><N><V><A><V><Y><S><I><Q><G><R><R><D><H><M><E><D><R><F><E><V><L><T><D><L><A><N><K><T><H><P><S><I><F><G><I><F><D><G><H><G><G><E><T><A><A><E><Y><V><K><S><R><L><P><E><A><L><K><Q><H><L><Q><D><Y><E><K><D><K><E><N><S><V><L><S><Y><Q><T><I><L><E><Q><Q><I><L><S><I><D><R><E><M><L><E><K><L><T><V><S><Y><D><E><A><G><T><T><C><L><I><A><L><L><S><D><K><D><L><T><V><A><N><V><G><D><S><R><G><V><L><C><D><K><D><G><N><A><I><P><L><S><H><D><H><K><P><Y><Q><L><K><E><R><K><R><I><K><R><A><G><G><F><I><S><F><N><G><S><W><R><V><Q><G><I><L><A><M><S><R><S><L><G><D><Y><P><L><K><N><L><N><V><V><I><P><D><P><D><I><L><T><F><D><L><D><K><L><Q><P><E><F><M><I><L><A><S><D><G><L><W><D><A><F><S><N><E><E><A><V><R><F><I><K><E><R><L><D><E><P><H><F><G><A><K><S><I><V><L><Q><S><F><Y><R><G><C><P><D><N><I><T><V><M><V><V><K><F><R><N><S><S><K><T><E><E><Q> | Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.<BOP> | Q5SGD2 |
O14649 | KCNK3_HUMAN | Two pore potassium channel KT3.1 | Homo | <M><K><R><Q><N><V><R><T><L><A><L><I><V><C><T><F><T><Y><L><L><V><G><A><A><V><F><D><A><L><E><S><E><P><E><L><I><E><R><Q><R><L><E><L><R><Q><Q><E><L><R><A><R><Y><N><L><S><Q><G><G><Y><E><E><L><E><R><V><V><L><R><L><K><P><H><K><A><G><V><Q><W><R><F><A><G><S><F><Y><F><A><I><T><V><I><T><T><I><G><Y><G><H><A><A><P><S><T><D><G><G><K><V><F><C><M><F><Y><A><L><L><G><I><P><L><T><L><V><M><F><Q><S><L><G><E><R><I><N><T><L><V><R><Y><L><L><H><R><A><K><K><G><L><G><M><R><R><A><D><V><S><M><A><N><M><V><L><I><G><F><F><S><C><I><S><T><L><C><I><G><A><A><A><F><S><H><Y><E><H><W><T><F><F><Q><A><Y><Y><Y><C><F><I><T><L><T><T><I><G><F><G><D><Y><V><A><L><Q><K><D><Q><A><L><Q><T><Q><P><Q><Y><V><A><F><S><F><V><Y><I><L><T><G><L><T><V><I><G><A><F><L><N><L><V><V><L><R><F><M><T><M><N><A><E><D><E><K><R><D><A><E><H><R><A><L><L><T><R><N><G><Q><A><G><G><G><G><G><G><G><S><A><H><T><T><D><T><A><S><S><T><A><A><A><G><G><G><G><F><R><N><V><Y><A><E><V><L><H><F><Q><S><M><C><S><C><L><W><Y><K><S><R><E><K><L><Q><Y><S><I><P><M><I><I><P><R><D><L><S><T><S><D><T><C><V><E><Q><S><H><S><S><P><G><G><G><G><R><Y><S><D><T><P><S><R><R><C><L><C><S><G><A><P><R><S><A><I><S><S><V><S><T><G><L><H><S><L><S><T><F><R><G><L><M><K><R><R><S><S><V> | pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<BOP> | O14649 |
P16150 | LEUK_HUMAN | CD43 cytoplasmic tail | Homo | <M><A><T><L><L><L><L><L><G><V><L><V><V><S><P><D><A><L><G><S><T><T><A><V><Q><T><P><T><S><G><E><P><L><V><S><T><S><E><P><L><S><S><K><M><Y><T><T><S><I><T><S><D><P><K><A><D><S><T><G><D><Q><T><S><A><L><P><P><S><T><S><I><N><E><G><S><P><L><W><T><S><I><G><A><S><T><G><S><P><L><P><E><P><T><T><Y><Q><E><V><S><I><K><M><S><S><V><P><Q><E><T><P><H><A><T><S><H><P><A><V><P><I><T><A><N><S><L><G><S><H><T><V><T><G><G><T><I><T><T><N><S><P><E><T><S><S><R><T><S><G><A><P><V><T><T><A><A><S><S><L><E><T><S><R><G><T><S><G><P><P><L><T><M><A><T><V><S><L><E><T><S><K><G><T><S><G><P><P><V><T><M><A><T><D><S><L><E><T><S><T><G><T><T><G><P><P><V><T><M><T><T><G><S><L><E><P><S><S><G><A><S><G><P><Q><V><S><S><V><K><L><S><T><M><M><S><P><T><T><S><T><N><A><S><T><V><P><F><R><N><P><D><E><N><S><R><G><M><L><P><V><A><V><L><V><A><L><L><A><V><I><V><L><V><A><L><L><L><L><W><R><R><R><Q><K><R><R><T><G><A><L><V><L><S><R><G><G><K><R><N><G><V><V><D><A><W><A><G><P><A><Q><V><P><E><E><G><A><V><T><V><T><V><G><G><S><G><G><D><K><G><S><G><F><P><D><G><E><G><S><S><R><R><P><T><L><T><T><F><F><G><R><R><K><S><R><Q><G><S><L><A><M><E><E><L><K><S><G><S><G><P><S><L><K><G><E><E><E><P><L><V><A><S><E><D><G><A><V><D><A><P><A><P><D><E><P><E><G><G><D><G><A><A><P> | Protects cells from apoptotic signals, promoting cell survival.<BOP> | P16150 |
Q16625 | OCLN_HUMAN | Occludin | Homo | <M><S><S><R><P><L><E><S><P><P><P><Y><R><P><D><E><F><K><P><N><H><Y><A><P><S><N><D><I><Y><G><G><E><M><H><V><R><P><M><L><S><Q><P><A><Y><S><F><Y><P><E><D><E><I><L><H><F><Y><K><W><T><S><P><P><G><V><I><R><I><L><S><M><L><I><I><V><M><C><I><A><I><F><A><C><V><A><S><T><L><A><W><D><R><G><Y><G><T><S><L><L><G><G><S><V><G><Y><P><Y><G><G><S><G><F><G><S><Y><G><S><G><Y><G><Y><G><Y><G><Y><G><Y><G><Y><G><G><Y><T><D><P><R><A><A><K><G><F><M><L><A><M><A><A><F><C><F><I><A><A><L><V><I><F><V><T><S><V><I><R><S><E><M><S><R><T><R><R><Y><Y><L><S><V><I><I><V><S><A><I><L><G><I><M><V><F><I><A><T><I><V><Y><I><M><G><V><N><P><T><A><Q><S><S><G><S><L><Y><G><S><Q><I><Y><A><L><C><N><Q><F><Y><T><P><A><A><T><G><L><Y><V><D><Q><Y><L><Y><H><Y><C><V><V><D><P><Q><E><A><I><A><I><V><L><G><F><M><I><I><V><A><F><A><L><I><I><F><F><A><V><K><T><R><R><K><M><D><R><Y><D><K><S><N><I><L><W><D><K><E><H><I><Y><D><E><Q><P><P><N><V><E><E><W><V><K><N><V><S><A><G><T><Q><D><V><P><S><P><P><S><D><Y><V><E><R><V><D><S><P><M><A><Y><S><S><N><G><K><V><N><D><K><R><F><Y><P><E><S><S><Y><K><S><T><P><V><P><E><V><V><Q><E><L><P><L><T><S><P><V><D><D><F><R><Q><P><R><Y><S><S><G><G><N><F><E><T><P><S><K><R><A><P><A><K><G><R><A><G><R><S><K><R><T><E><Q><D><H><Y><E><T><D><Y><T><T><G><G><E><S><C><D><E><L><E><E><D><W><I><R><E><Y><P><P><I><T><S><D><Q><Q><R><Q><L><Y><K><R><N><F><D><T><G><L><Q><E><Y><K><S><L><Q><S><E><L><D><E><I><N><K><E><L><S><R><L><D><K><E><L><D><D><Y><R><E><E><S><E><E><Y><M><A><A><A><D><E><Y><N><R><L><K><Q><V><K><G><S><A><D><Y><K><S><K><K><N><H><C><K><Q><L><K><S><K><L><S><H><I><K><K><M><V><G><D><Y><D><R><Q><K><T> | (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.<BOP> | Q16625 |
Q7RTU7 | SCX_HUMAN | Class A basic helix-loop-helix protein 48 | Homo | <M><S><F><A><T><L><R><P><A><P><P><G><R><Y><L><Y><P><E><V><S><P><L><S><E><D><E><D><R><G><S><D><S><S><G><S><D><E><K><P><C><R><V><H><A><A><R><C><G><L><Q><G><A><R><R><R><A><G><G><R><R><A><G><G><G><G><P><G><G><R><P><G><R><E><P><R><Q><R><H><T><A><N><A><R><E><R><D><R><T><N><S><V><N><T><A><F><T><A><L><R><T><L><I><P><T><E><P><A><D><R><K><L><S><K><I><E><T><L><R><L><A><S><S><Y><I><S><H><L><G><N><V><L><L><A><G><E><A><C><G><D><G><Q><P><C><H><S><G><P><A><F><F><H><A><A><R><A><G><S><P><P><P><P><P><P><P><P><P><A><R><D><G><E><N><T><Q><P><K><Q><I><C><T><F><C><L><S><N><Q><R><K><L><S><K><D><R><D><R><K><T><A><I><R><S> | Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.<BOP> | Q7RTU7 |
Q8NGN7 | O10D4_HUMAN | Putative olfactory receptor 10D4 | Homo | <M><R><N><H><T><M><V><T><E><F><I><L><L><G><I><P><E><T><E><G><L><E><T><A><L><L><F><L><F><S><S><F><Y><L><C><T><L><L><G><N><V><L><I><L><T><A><I><I><S><S><T><R><L><H><T><P><M><Y><F><F><L><G><N><L><S><I><F><D><L><G><F><S><S><T><T><V><P><K><M><L><F><Y><L><S><G><N><S><H><A><I><S><Y><A><G><C><V><S><Q><L><F><F><Y><H><F><L><G><C><T><E><C><F><L><Y><T><V><M><A><C><D><R><F><V><A><I><C><F><P><L><R><Y><T><V><I><M><N><H><R><V><C><F><M><L><A><T><G><T><W><M><I><G><C><V><H><A><M><I><L><T><P><L><T><F><Q><L><P><Y><C><G><P><N><K><V><G><Y><Y><F><C><D><I><P><A><V><L><P><L><A><C><K><D><T><S><L><A><Q><R><V><G><F><T><N><V><G><L><L><S><L><I><C><F><F><L><I><L><V><S><Y><T><C><I><G><I><S><I><S><K><I><R><S><A><E><G><R><Q><R><A><F><S><T><C><S><A><H><L><T><A><I><L><C><A><Y><G><P><V><I><V><I><Y><L><Q><P><N><P><S><A><L><L><G><S><I><I><Q><I><L><N><N><L><V><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><S><D><Q><P> | Odorant receptor.<BOP> | Q8NGN7 |
Q9ULV4 | COR1C_HUMAN | hCRNN4 | Homo | <M><R><R><V><V><R><Q><S><K><F><R><H><V><F><G><Q><A><V><K><N><D><Q><C><Y><D><D><I><R><V><S><R><V><T><W><D><S><S><F><C><A><V><N><P><R><F><V><A><I><I><I><E><A><S><G><G><G><A><F><L><V><L><P><L><H><K><T><G><R><I><D><K><S><Y><P><T><V><C><G><H><T><G><P><V><L><D><I><D><W><C><P><H><N><D><Q><V><I><A><S><G><S><E><D><C><T><V><M><V><W><Q><I><P><E><N><G><L><T><L><S><L><T><E><P><V><V><I><L><E><G><H><S><K><R><V><G><I><V><A><W><H><P><T><A><R><N><V><L><L><S><A><G><C><D><N><A><I><I><I><W><N><V><G><T><G><E><A><L><I><N><L><D><D><M><H><S><D><M><I><Y><N><V><S><W><N><R><N><G><S><L><I><C><T><A><S><K><D><K><K><V><R><V><I><D><P><R><K><Q><E><I><V><A><E><K><E><K><A><H><E><G><A><R><P><M><R><A><I><F><L><A><D><G><N><V><F><T><T><G><F><S><R><M><S><E><R><Q><L><A><L><W><N><P><K><N><M><Q><E><P><I><A><L><H><E><M><D><T><S><N><G><V><L><L><P><F><Y><D><P><D><T><S><I><I><Y><L><C><G><K><G><D><S><S><I><R><Y><F><E><I><T><D><E><S><P><Y><V><H><Y><L><N><T><F><S><S><K><E><P><Q><R><G><M><G><Y><M><P><K><R><G><L><D><V><N><K><C><E><I><A><R><F><F><K><L><H><E><R><K><C><E><P><I><I><M><T><V><P><R><K><S><D><L><F><Q><D><D><L><Y><P><D><T><A><G><P><E><A><A><L><E><A><E><E><W><F><E><G><K><N><A><D><P><I><L><I><S><L><K><H><G><Y><I><P><G><K><N><R><D><L><K><V><V><K><K><N><I><L><D><S><K><P><T><A><N><K><K><C><D><L><I><S><I><P><K><K><T><T><D><T><A><S><V><Q><N><E><A><K><L><D><E><I><L><K><E><I><K><S><I><K><D><T><I><C><N><Q><D><E><R><I><S><K><L><E><Q><Q><M><A><K><I><A><A> | Involved in myogenic differentiation.<BOP> | Q9ULV4 |
P46091 | CML2_HUMAN | G-protein coupled receptor 1 | Homo | <M><E><D><L><E><E><T><L><F><E><E><F><E><N><Y><S><Y><D><L><D><Y><Y><S><L><E><S><D><L><E><E><K><V><Q><L><G><V><V><H><W><V><S><L><V><L><Y><C><L><A><F><V><L><G><I><P><G><N><A><I><V><I><W><F><T><G><F><K><W><K><K><T><V><T><T><L><W><F><L><N><L><A><I><A><D><F><I><F><L><L><F><L><P><L><Y><I><S><Y><V><A><M><N><F><H><W><P><F><G><I><W><L><C><K><A><N><S><F><T><A><Q><L><N><M><F><A><S><V><F><F><L><T><V><I><S><L><D><H><Y><I><H><L><I><H><P><V><L><S><H><R><H><R><T><L><K><N><S><L><I><V><I><I><F><I><W><L><L><A><S><L><I><G><G><P><A><L><Y><F><R><D><T><V><E><F><N><N><H><T><L><C><Y><N><N><F><Q><K><H><D><P><D><L><T><L><I><R><H><H><V><L><T><W><V><K><F><I><I><G><Y><L><F><P><L><L><T><M><S><I><C><Y><L><C><L><I><F><K><V><K><K><R><S><I><L><I><S><S><R><H><F><W><T><I><L><V><V><V><V><A><F><V><V><C><W><T><P><Y><H><L><F><S><I><W><E><L><T><I><H><H><N><S><Y><S><H><H><V><M><Q><A><G><I><P><L><S><T><G><L><A><F><L><N><S><C><L><N><P><I><L><Y><V><L><I><S><K><K><F><Q><A><R><F><R><S><S><V><A><E><I><L><K><Y><T><L><W><E><V><S><C><S><G><T><V><S><E><Q><L><R><N><S><E><T><K><N><L><C><L><L><E><T><A><Q> | (Microbial infection) Coreceptor for HIV-1.<BOP> | P46091 |
Q53S33 | BOLA3_HUMAN | BolA-like protein 3 | Homo | <M><A><A><W><S><P><A><A><A><A><P><L><L><R><G><I><R><G><L><P><L><H><H><R><M><F><A><T><Q><T><E><G><E><L><R><V><T><Q><I><L><K><E><K><F><P><R><A><T><A><I><K><V><T><D><I><S><G><G><C><G><A><M><Y><E><I><K><I><E><S><E><E><F><K><E><K><R><T><V><Q><Q><H><Q><M><V><N><Q><A><L><K><E><E><I><K><E><M><H><G><L><R><I><F><T><S><V><P><K><R> | Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 .<BOP> | Q53S33 |
Q12933 | TRAF2_HUMAN | Tumor necrosis factor type 2 receptor-associated protein 3 | Homo | <M><A><A><A><S><V><T><P><P><G><S><L><E><L><L><Q><P><G><F><S><K><T><L><L><G><T><K><L><E><A><K><Y><L><C><S><A><C><R><N><V><L><R><R><P><F><Q><A><Q><C><G><H><R><Y><C><S><F><C><L><A><S><I><L><S><S><G><P><Q><N><C><A><A><C><V><H><E><G><I><Y><E><E><G><I><S><I><L><E><S><S><S><A><F><P><D><N><A><A><R><R><E><V><E><S><L><P><A><V><C><P><S><D><G><C><T><W><K><G><T><L><K><E><Y><E><S><C><H><E><G><R><C><P><L><M><L><T><E><C><P><A><C><K><G><L><V><R><L><G><E><K><E><R><H><L><E><H><E><C><P><E><R><S><L><S><C><R><H><C><R><A><P><C><C><G><A><D><V><K><A><H><H><E><V><C><P><K><F><P><L><T><C><D><G><C><G><K><K><K><I><P><R><E><K><F><Q><D><H><V><K><T><C><G><K><C><R><V><P><C><R><F><H><A><I><G><C><L><E><T><V><E><G><E><K><Q><Q><E><H><E><V><Q><W><L><R><E><H><L><A><M><L><L><S><S><V><L><E><A><K><P><L><L><G><D><Q><S><H><A><G><S><E><L><L><Q><R><C><E><S><L><E><K><K><T><A><T><F><E><N><I><V><C><V><L><N><R><E><V><E><R><V><A><M><T><A><E><A><C><S><R><Q><H><R><L><D><Q><D><K><I><E><A><L><S><S><K><V><Q><Q><L><E><R><S><I><G><L><K><D><L><A><M><A><D><L><E><Q><K><V><L><E><M><E><A><S><T><Y><D><G><V><F><I><W><K><I><S><D><F><A><R><K><R><Q><E><A><V><A><G><R><I><P><A><I><F><S><P><A><F><Y><T><S><R><Y><G><Y><K><M><C><L><R><I><Y><L><N><G><D><G><T><G><R><G><T><H><L><S><L><F><F><V><V><M><K><G><P><N><D><A><L><L><R><W><P><F><N><Q><K><V><T><L><M><L><L><D><Q><N><N><R><E><H><V><I><D><A><F><R><P><D><V><T><S><S><S><F><Q><R><P><V><N><D><M><N><I><A><S><G><C><P><L><F><C><P><V><S><K><M><E><A><K><N><S><Y><V><R><D><D><A><I><F><I><K><A><I><V><D><L><T><G><L> | Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.<BOP> | Q12933 |
Q13509 | TBB3_HUMAN | Tubulin beta-III | Homo | <M><R><E><I><V><H><I><Q><A><G><Q><C><G><N><Q><I><G><A><K><F><W><E><V><I><S><D><E><H><G><I><D><P><S><G><N><Y><V><G><D><S><D><L><Q><L><E><R><I><S><V><Y><Y><N><E><A><S><S><H><K><Y><V><P><R><A><I><L><V><D><L><E><P><G><T><M><D><S><V><R><S><G><A><F><G><H><L><F><R><P><D><N><F><I><F><G><Q><S><G><A><G><N><N><W><A><K><G><H><Y><T><E><G><A><E><L><V><D><S><V><L><D><V><V><R><K><E><C><E><N><C><D><C><L><Q><G><F><Q><L><T><H><S><L><G><G><G><T><G><S><G><M><G><T><L><L><I><S><K><V><R><E><E><Y><P><D><R><I><M><N><T><F><S><V><V><P><S><P><K><V><S><D><T><V><V><E><P><Y><N><A><T><L><S><I><H><Q><L><V><E><N><T><D><E><T><Y><C><I><D><N><E><A><L><Y><D><I><C><F><R><T><L><K><L><A><T><P><T><Y><G><D><L><N><H><L><V><S><A><T><M><S><G><V><T><T><S><L><R><F><P><G><Q><L><N><A><D><L><R><K><L><A><V><N><M><V><P><F><P><R><L><H><F><F><M><P><G><F><A><P><L><T><A><R><G><S><Q><Q><Y><R><A><L><T><V><P><E><L><T><Q><Q><M><F><D><A><K><N><M><M><A><A><C><D><P><R><H><G><R><Y><L><T><V><A><T><V><F><R><G><R><M><S><M><K><E><V><D><E><Q><M><L><A><I><Q><S><K><N><S><S><Y><F><V><E><W><I><P><N><N><V><K><V><A><V><C><D><I><P><P><R><G><L><K><M><S><S><T><F><I><G><N><S><T><A><I><Q><E><L><F><K><R><I><S><E><Q><F><T><A><M><F><R><R><K><A><F><L><H><W><Y><T><G><E><G><M><D><E><M><E><F><T><E><A><E><S><N><M><N><D><L><V><S><E><Y><Q><Q><Y><Q><D><A><T><A><E><E><E><G><E><M><Y><E><D><D><E><E><E><S><E><A><Q><G><P><K> | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers . Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms . Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin . TUBB3 plays a critical role in proper axon guidance and maintenance . Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Plays a role in dorsal root ganglion axon projection towards the spinal cord .<BOP> | Q13509 |
Q96CK0 | ZN653_HUMAN | Zinc finger protein Zip67 | Homo | <M><A><E><R><A><L><E><P><E><A><E><A><E><A><E><A><G><A><G><G><E><A><A><A><E><E><G><A><A><G><R><K><A><R><G><R><P><R><L><T><E><S><D><R><A><R><R><R><L><E><S><R><K><K><Y><D><V><R><R><V><Y><L><G><E><A><H><G><P><W><V><D><L><R><R><R><S><G><W><S><D><A><K><L><A><A><Y><L><I><S><L><E><R><G><Q><R><S><G><R><H><G><K><P><W><E><Q><V><P><K><K><P><K><R><K><K><R><R><R><R><N><V><N><C><L><K><N><V><V><I><W><Y><E><D><H><K><H><R><C><P><Y><E><P><H><L><A><E><L><D><P><T><F><G><L><Y><T><T><A><V><W><Q><C><E><A><G><H><R><Y><F><Q><D><L><H><S><P><L><K><P><L><S><D><S><D><P><D><S><D><K><V><G><N><G><L><V><A><G><S><S><D><S><S><S><S><G><S><A><S><D><S><E><E><S><P><E><G><Q><P><V><K><A><A><A><A><A><A><A><A><T><P><T><S><P><V><G><S><S><G><L><I><T><Q><E><G><V><H><I><P><F><D><V><H><H><V><E><S><L><A><E><Q><G><T><P><L><C><S><N><P><A><G><N><G><P><E><A><L><E><T><V><V><C><V><P><V><P><V><Q><V><G><A><G><P><S><A><L><F><E><N><V><P><Q><E><A><L><G><E><V><V><A><S><C><P><M><P><G><M><V><P><G><S><Q><V><I><I><I><A><G><P><G><Y><D><A><L><T><A><E><G><I><H><L><N><M><A><A><G><S><G><V><P><G><S><G><L><G><E><E><V><P><C><A><M><M><E><G><V><A><A><Y><T><Q><T><E><P><E><G><S><Q><P><S><T><M><D><A><T><A><V><A><G><I><E><T><K><K><E><K><E><D><L><C><L><L><K><K><E><E><K><E><E><P><V><A><P><E><L><A><T><T><V><P><E><S><A><E><P><E><A><E><A><D><G><E><E><L><D><G><S><D><M><S><A><I><I><Y><E><I><P><K><E><P><E><K><R><R><R><S><K><R><S><R><V><M><D><A><D><G><L><L><E><M><F><H><C><P><Y><E><G><C><S><Q><V><Y><V><A><L><S><S><F><Q><N><H><V><N><L><V><H><R><K><G><K><T><K><V><C><P><H><P><G><C><G><K><K><F><Y><L><S><N><H><L><R><R><H><M><I><I><H><S><G><V><R><E><F><T><C><E><T><C><G><K><S><F><K><R><K><N><H><L><E><V><H><R><R><T><H><T><G><E><T><P><L><Q><C><E><I><C><G><Y><Q><C><R><Q><R><A><S><L><N><W><H><M><K><K><H><T><A><E><V><Q><Y><N><F><T><C><D><R><C><G><K><R><F><E><K><L><D><S><V><K><F><H><T><L><K><S><H><P><D><H><K><P><T> | Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.<BOP> | Q96CK0 |
Q96SD1 | DCR1C_HUMAN | SNM1-like protein | Homo | <M><S><S><F><E><G><Q><M><A><E><Y><P><T><I><S><I><D><R><F><D><R><E><N><L><R><A><R><A><Y><F><L><S><H><C><H><K><D><H><M><K><G><L><R><A><P><T><L><K><R><R><L><E><C><S><L><K><V><Y><L><Y><C><S><P><V><T><K><E><L><L><L><T><S><P><K><Y><R><F><W><K><K><R><I><I><S><I><E><I><E><T><P><T><Q><I><S><L><V><D><E><A><S><G><E><K><E><E><I><V><V><T><L><L><P><A><G><H><C><P><G><S><V><M><F><L><F><Q><G><N><N><G><T><V><L><Y><T><G><D><F><R><L><A><Q><G><E><A><A><R><M><E><L><L><H><S><G><G><R><V><K><D><I><Q><S><V><Y><L><D><T><T><F><C><D><P><R><F><Y><Q><I><P><S><R><E><E><C><L><S><G><V><L><E><L><V><R><S><W><I><T><R><S><P><Y><H><V><V><W><L><N><C><K><A><A><Y><G><Y><E><Y><L><F><T><N><L><S><E><E><L><G><V><Q><V><H><V><N><K><L><D><M><F><R><N><M><P><E><I><L><H><H><L><T><T><D><R><N><T><Q><I><H><A><C><R><H><P><K><A><E><E><Y><F><Q><W><S><K><L><P><C><G><I><T><S><R><N><R><I><P><L><H><I><I><S><I><K><P><S><T><M><W><F><G><E><R><S><R><K><T><N><V><I><V><R><T><G><E><S><S><Y><R><A><C><F><S><F><H><S><S><Y><S><E><I><K><D><F><L><S><Y><L><C><P><V><N><A><Y><P><N><V><I><P><V><G><T><T><M><D><K><V><V><E><I><L><K><P><L><C><R><S><S><Q><S><T><E><P><K><Y><K><P><L><G><K><L><K><R><A><R><T><V><H><R><D><S><E><E><E><D><D><Y><L><F><D><D><P><L><P><I><P><L><R><H><K><V><P><Y><P><E><T><F><H><P><E><V><F><S><M><T><A><V><S><E><K><Q><P><E><K><L><R><Q><T><P><G><C><C><R><A><E><C><M><Q><S><S><R><F><T><N><F><V><D><C><E><E><S><N><S><E><S><E><E><E><V><G><I><P><A><S><L><Q><G><D><L><G><S><V><L><H><L><Q><K><A><D><G><D><V><P><Q><W><E><V><F><F><K><R><N><D><E><I><T><D><E><S><L><E><N><F><P><S><S><T><V><A><G><G><S><Q><S><P><K><L><F><S><D><S><D><G><E><S><T><H><I><S><S><Q><N><S><S><Q><S><T><H><I><T><E><Q><G><S><Q><G><W><D><S><Q><S><D><T><V><L><L><S><S><Q><E><R><N><S><G><D><I><T><S><L><D><K><A><D><Y><R><P><T><I><K><E><N><I><P><A><S><L><M><E><Q><N><V><I><C><P><K><D><T><Y><S><D><L><K><S><R><D><K><D><V><T><I><V><P><S><T><G><E><P><T><T><L><S><S><E><T><H><I><P><E><E><K><S><L><L><N><L><S><T><N><A><D><S><Q><S><S><S><D><F><E><V><P><S><T><P><E><A><E><L><P><K><R><E><H><L><Q><Y><L><Y><E><K><L><A><T><G><E><S><I><A><V><K><K><R><K><C><S><L><L><D><T> | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination . Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments . V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) . These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends . These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively . This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC . The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint . Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior | Q96SD1 |
P0CE72 | ONCO_HUMAN | Parvalbumin beta | Homo | <M><S><I><T><D><V><L><S><A><D><D><I><A><A><A><L><Q><E><C><R><D><P><D><T><F><E><P><Q><K><F><F><Q><T><S><G><L><S><K><M><S><A><N><Q><V><K><D><V><F><R><F><I><D><N><D><Q><S><G><Y><L><D><E><E><E><L><K><F><F><L><Q><K><F><E><S><G><A><R><E><L><T><E><S><E><T><K><S><L><M><A><A><A><D><N><D><G><D><G><K><I><G><A><E><E><F><Q><E><M><V><H><S> | Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.<BOP> | P0CE72 |
P43353 | AL3B1_HUMAN | Aldehyde dehydrogenase 7 | Homo | <M><D><P><L><G><D><T><L><R><R><L><R><E><A><F><H><A><G><R><T><R><P><A><E><F><R><A><A><Q><L><Q><G><L><G><R><F><L><Q><E><N><K><Q><L><L><H><D><A><L><A><Q><D><L><H><K><S><A><F><E><S><E><V><S><E><V><A><I><S><Q><G><E><V><T><L><A><L><R><N><L><R><A><W><M><K><D><E><R><V><P><K><N><L><A><T><Q><L><D><S><A><F><I><R><K><E><P><F><G><L><V><L><I><I><A><P><W><N><Y><P><L><N><L><T><L><V><P><L><V><G><A><L><A><A><G><N><C><V><V><L><K><P><S><E><I><S><K><N><V><E><K><I><L><A><E><V><L><P><Q><Y><V><D><Q><S><C><F><A><V><V><L><G><G><P><Q><E><T><G><Q><L><L><E><H><R><F><D><Y><I><F><F><T><G><S><P><R><V><G><K><I><V><M><T><A><A><A><K><H><L><T><P><V><T><L><E><L><G><G><K><N><P><C><Y><V><D><D><N><C><D><P><Q><T><V><A><N><R><V><A><W><F><R><Y><F><N><A><G><Q><T><C><V><A><P><D><Y><V><L><C><S><P><E><M><Q><E><R><L><L><P><A><L><Q><S><T><I><T><R><F><Y><G><D><D><P><Q><S><S><P><N><L><G><R><I><I><N><Q><K><Q><F><Q><R><L><R><A><L><L><G><C><G><R><V><A><I><G><G><Q><S><D><E><S><D><R><Y><I><A><P><T><V><L><V><D><V><Q><E><M><E><P><V><M><Q><E><E><I><F><G><P><I><L><P><I><V><N><V><Q><S><L><D><E><A><I><E><F><I><N><R><R><E><K><P><L><A><L><Y><A><F><S><N><S><S><Q><V><V><K><R><V><L><T><Q><T><S><S><G><G><F><C><G><N><D><G><F><M><H><M><T><L><A><S><L><P><F><G><G><V><G><A><S><G><M><G><R><Y><H><G><K><F><S><F><D><T><F><S><H><H><R><A><C><L><L><R><S><P><G><M><E><K><L><N><A><L><R><Y><P><P><Q><S><P><R><R><L><R><M><L><L><V><A><M><E><A><Q><G><C><S><C><T><L><L> | Oxidizes medium and long chain saturated and unsaturated aldehydes . Metabolizes also benzaldehyde . Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde . May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor . May have a protective role against the cytotoxicity induced by lipid peroxidation .<BOP> | P43353 |
P25800 | RBTN1_HUMAN | T-cell translocation protein 1 | Homo | <M><M><V><L><D><K><E><D><G><V><P><M><L><S><V><Q><P><K><G><K><Q><K><G><C><A><G><C><N><R><K><I><K><D><R><Y><L><L><K><A><L><D><K><Y><W><H><E><D><C><L><K><C><A><C><C><D><C><R><L><G><E><V><G><S><T><L><Y><T><K><A><N><L><I><L><C><R><R><D><Y><L><R><L><F><G><T><T><G><N><C><A><A><C><S><K><L><I><P><A><F><E><M><V><M><R><A><R><D><N><V><Y><H><L><D><C><F><A><C><Q><L><C><N><Q><R><F><C><V><G><D><K><F><F><L><K><N><N><M><I><L><C><Q><M><D><Y><E><E><G><Q><L><N><G><T><F><E><S><Q><V><Q> | May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.<BOP> | P25800 |
O60232 | ZNRD2_HUMAN | Zinc ribbon domain-containing protein 2 | Homo | <M><A><L><N><G><A><E><V><D><D><F><S><W><E><P><P><T><E><A><E><T><K><V><L><Q><A><R><R><E><R><Q><D><R><I><S><R><L><M><G><D><Y><L><L><R><G><Y><R><M><L><G><E><T><C><A><D><C><G><T><I><L><L><Q><D><K><Q><R><K><I><Y><C><V><A><C><Q><E><L><D><S><D><V><D><K><D><N><P><A><L><N><A><Q><A><A><L><S><Q><A><R><E><H><Q><L><A><S><A><S><E><L><P><L><G><S><R><P><A><P><Q><P><P><V><P><R><P><E><H><C><E><G><A><A><A><G><L><K><A><A><Q><G><P><P><A><P><A><V><P><P><N><T><D><V><M><A><C><T><Q><T><A><L><L><Q><K><L><T><W><A><S><A><E><L><G><S><S><T><S><L><E><T><S><I><Q><L><C><G><L><I><R><A><C><A><E><A><L><R><S><L><Q><Q><L><Q><H> | Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.<BOP> | O60232 |
P09693 | CD3G_HUMAN | T-cell receptor T3 gamma chain | Homo | <M><E><Q><G><K><G><L><A><V><L><I><L><A><I><I><L><L><Q><G><T><L><A><Q><S><I><K><G><N><H><L><V><K><V><Y><D><Y><Q><E><D><G><S><V><L><L><T><C><D><A><E><A><K><N><I><T><W><F><K><D><G><K><M><I><G><F><L><T><E><D><K><K><K><W><N><L><G><S><N><A><K><D><P><R><G><M><Y><Q><C><K><G><S><Q><N><K><S><K><P><L><Q><V><Y><Y><R><M><C><Q><N><C><I><E><L><N><A><A><T><I><S><G><F><L><F><A><E><I><V><S><I><F><V><L><A><V><G><V><Y><F><I><A><G><Q><D><G><V><R><Q><S><R><A><S><D><K><Q><T><L><L><P><N><D><Q><L><Y><Q><P><L><K><D><R><E><D><D><Q><Y><S><H><L><Q><G><N><Q><L><R><R><N> | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface . Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.<BOP> | P09693 |
Q9HB31 | SEBOX_HUMAN | Skin-, embryo-, brain- and oocyte-specific homeobox | Homo | <M><P><S><P><V><D><A><S><S><A><D><G><G><S><G><L><G><S><H><R><R><K><R><T><T><F><S><K><G><Q><L><L><E><L><E><R><A><F><A><A><W><P><Y><P><N><I><S><T><H><E><H><L><A><W><V><T><C><L><P><E><A><K><V><Q><V><W><F><Q><K><R><W><A><K><I><I><K><N><R><K><S><G><I><L><S><P><G><S><E><C><P><Q><S><S><C><S><L><P><D><T><L><Q><Q><P><W><D><P><Q><M><P><G><Q><P><P><P><S><S><G><T><P><Q><R><T><S><V><C><R><H><S><S><C><P><A><P><G><L><S><P><R><Q><G><W><E><G><A><K><A><V><A><P><W><G><S><A><G><A><S><E><V><H><P><S><L><E><R><A><T><P><Q><T><S><L><G><S><L><S><D><L><I><Y><A><L><A><I><V><V><N><V><D><H><S> | Probable transcription factor involved in the control of specification of mesoderm and endoderm.<BOP> | Q9HB31 |
Q9H0C8 | ILKAP_HUMAN | Integrin-linked kinase-associated serine/threonine phosphatase 2C | Homo | <M><D><L><F><G><D><L><P><E><P><E><R><S><P><R><P><A><A><G><K><E><A><Q><K><G><P><L><L><F><D><D><L><P><P><A><S><S><T><D><S><G><S><G><G><P><L><L><F><D><D><L><P><P><A><S><S><G><D><S><G><S><L><A><T><S><I><S><Q><M><V><K><T><E><G><K><G><A><K><R><K><T><S><E><E><E><K><N><G><S><E><E><L><V><E><K><K><V><C><K><A><S><S><V><I><F><G><L><K><G><Y><V><A><E><R><K><G><E><R><E><E><M><Q><D><A><H><V><I><L><N><D><I><T><E><E><C><R><P><P><S><S><L><I><T><R><V><S><Y><F><A><V><F><D><G><H><G><G><I><R><A><S><K><F><A><A><Q><N><L><H><Q><N><L><I><R><K><F><P><K><G><D><V><I><S><V><E><K><T><V><K><R><C><L><L><D><T><F><K><H><T><D><E><E><F><L><K><Q><A><S><S><Q><K><P><A><W><K><D><G><S><T><A><T><C><V><L><A><V><D><N><I><L><Y><I><A><N><L><G><D><S><R><A><I><L><C><R><Y><N><E><E><S><Q><K><H><A><A><L><S><L><S><K><E><H><N><P><T><Q><Y><E><E><R><M><R><I><Q><K><A><G><G><N><V><R><D><G><R><V><L><G><V><L><E><V><S><R><S><I><G><D><G><Q><Y><K><R><C><G><V><T><S><V><P><D><I><R><R><C><Q><L><T><P><N><D><R><F><I><L><L><A><C><D><G><L><F><K><V><F><T><P><E><E><A><V><N><F><I><L><S><C><L><E><D><E><K><I><Q><T><R><E><G><K><S><A><A><D><A><R><Y><E><A><A><C><N><R><L><A><N><K><A><V><Q><R><G><S><A><D><N><V><T><V><M><V><V><R><I><G><H> | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.<BOP> | Q9H0C8 |
Q16773 | KAT1_HUMAN | Kynurenine--oxoglutarate transaminase I | Homo | <M><A><K><Q><L><Q><A><R><R><L><D><G><I><D><Y><N><P><W><V><E><F><V><K><L><A><S><E><H><D><V><V><N><L><G><Q><G><F><P><D><F><P><P><P><D><F><A><V><E><A><F><Q><H><A><V><S><G><D><F><M><L><N><Q><Y><T><K><T><F><G><Y><P><P><L><T><K><I><L><A><S><F><F><G><E><L><L><G><Q><E><I><D><P><L><R><N><V><L><V><T><V><G><G><Y><G><A><L><F><T><A><F><Q><A><L><V><D><E><G><D><E><V><I><I><I><E><P><F><F><D><C><Y><E><P><M><T><M><M><A><G><G><R><P><V><F><V><S><L><K><P><G><P><I><Q><N><G><E><L><G><S><S><S><N><W><Q><L><D><P><M><E><L><A><G><K><F><T><S><R><T><K><A><L><V><L><N><T><P><N><N><P><L><G><K><V><F><S><R><E><E><L><E><L><V><A><S><L><C><Q><Q><H><D><V><V><C><I><T><D><E><V><Y><Q><W><M><V><Y><D><G><H><Q><H><I><S><I><A><S><L><P><G><M><W><E><R><T><L><T><I><G><S><A><G><K><T><F><S><A><T><G><W><K><V><G><W><V><L><G><P><D><H><I><M><K><H><L><R><T><V><H><Q><N><S><V><F><H><C><P><T><Q><S><Q><A><A><V><A><E><S><F><E><R><E><Q><L><L><F><R><Q><P><S><S><Y><F><V><Q><F><P><Q><A><M><Q><R><C><R><D><H><M><I><R><S><L><Q><S><V><G><L><K><P><I><I><P><Q><G><S><Y><F><L><I><T><D><I><S><D><F><K><R><K><M><P><D><L><P><G><A><V><D><E><P><Y><D><R><R><F><V><K><W><M><I><K><N><K><G><L><V><A><I><P><V><S><I><F><Y><S><V><P><H><Q><K><H><F><D><H><Y><I><R><F><C><F><V><K><D><E><A><T><L><Q><A><M><D><E><K><L><R><K><W><K><V><E><L> | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others . Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites . Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond .<BOP> | Q16773 |
O43175 | SERA_HUMAN | Malate dehydrogenase | Homo | <M><A><F><A><N><L><R><K><V><L><I><S><D><S><L><D><P><C><C><R><K><I><L><Q><D><G><G><L><Q><V><V><E><K><Q><N><L><S><K><E><E><L><I><A><E><L><Q><D><C><E><G><L><I><V><R><S><A><T><K><V><T><A><D><V><I><N><A><A><E><K><L><Q><V><V><G><R><A><G><T><G><V><D><N><V><D><L><E><A><A><T><R><K><G><I><L><V><M><N><T><P><N><G><N><S><L><S><A><A><E><L><T><C><G><M><I><M><C><L><A><R><Q><I><P><Q><A><T><A><S><M><K><D><G><K><W><E><R><K><K><F><M><G><T><E><L><N><G><K><T><L><G><I><L><G><L><G><R><I><G><R><E><V><A><T><R><M><Q><S><F><G><M><K><T><I><G><Y><D><P><I><I><S><P><E><V><S><A><S><F><G><V><Q><Q><L><P><L><E><E><I><W><P><L><C><D><F><I><T><V><H><T><P><L><L><P><S><T><T><G><L><L><N><D><N><T><F><A><Q><C><K><K><G><V><R><V><V><N><C><A><R><G><G><I><V><D><E><G><A><L><L><R><A><L><Q><S><G><Q><C><A><G><A><A><L><D><V><F><T><E><E><P><P><R><D><R><A><L><V><D><H><E><N><V><I><S><C><P><H><L><G><A><S><T><K><E><A><Q><S><R><C><G><E><E><I><A><V><Q><F><V><D><M><V><K><G><K><S><L><T><G><V><V><N><A><Q><A><L><T><S><A><F><S><P><H><T><K><P><W><I><G><L><A><E><A><L><G><T><L><M><R><A><W><A><G><S><P><K><G><T><I><Q><V><I><T><Q><G><T><S><L><K><N><A><G><N><C><L><S><P><A><V><I><V><G><L><L><K><E><A><S><K><Q><A><D><V><N><L><V><N><A><K><L><L><V><K><E><A><G><L><N><V><T><T><S><H><S><P><A><A><P><G><E><Q><G><F><G><E><C><L><L><A><V><A><L><A><G><A><P><Y><Q><A><V><G><L><V><Q><G><T><T><P><V><L><Q><G><L><N><G><A><V><F><R><P><E><V><P><L><R><R><D><L><P><L><L><L><F><R><T><Q><T><S><D><P><A><M><L><P><T><M><I><G><L><L><A><E><A><G><V><R><L><L><S><Y><Q><T><S><L><V><S><D><G><E><T><W><H><V><M><G><I><S><S><L><L><P><S><L><E><A><W><K><Q><H><V><T><E><A><F><Q><F><H><F> | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.<BOP> | O43175 |
Q9Y4J8 | DTNA_HUMAN | Dystrophin-related protein 3 | Homo | <M><I><E><D><S><G><K><R><G><N><T><M><A><E><R><R><Q><L><F><A><E><M><R><A><Q><D><L><D><R><I><R><L><S><T><Y><R><T><A><C><K><L><R><F><V><Q><K><K><C><N><L><H><L><V><D><I><W><N><V><I><E><A><L><R><E><N><A><L><N><N><L><D><P><N><T><E><L><N><V><S><R><L><E><A><V><L><S><T><I><F><Y><Q><L><N><K><R><M><P><T><T><H><Q><I><H><V><E><Q><S><I><S><L><L><L><N><F><L><L><A><A><F><D><P><E><G><H><G><K><I><S><V><F><A><V><K><M><A><L><A><T><L><C><G><G><K><I><M><D><K><L><R><Y><I><F><S><M><I><S><D><S><S><G><V><M><V><Y><G><R><Y><D><Q><F><L><R><E><V><L><K><L><P><T><A><V><F><E><G><P><S><F><G><Y><T><E><Q><S><A><R><S><C><F><S><Q><Q><K><K><V><T><L><N><G><F><L><D><T><L><M><S><D><P><P><P><Q><C><L><V><W><L><P><L><L><H><R><L><A><N><V><E><N><V><F><H><P><V><E><C><S><Y><C><H><S><E><S><M><M><G><F><R><Y><R><C><Q><Q><C><H><N><Y><Q><L><C><Q><D><C><F><W><R><G><H><A><G><G><S><H><S><N><Q><H><Q><M><K><E><Y><T><S><W><K><S><P><A><K><K><L><T><N><A><L><S><K><S><L><S><C><A><S><S><R><E><P><L><H><P><M><F><P><D><Q><P><E><K><P><L><N><L><A><H><I><V><D><T><W><P><P><R><P><V><T><S><M><N><D><T><L><F><S><H><S><V><P><S><S><G><S><P><F><I><T><R><S><S><P><P><K><D><S><E><V><E><Q><N><K><L><L><A><R><A><A><P><A><F><L><K><G><K><G><I><Q><Y><S><L><N><V><A><D><R><L><A><D><E><H><V><L><I><G><L><Y><V><N><M><L><R><N><N><P><S><C><M><L><E><S><S><N><R><L><D><E><E><H><R><L><I><A><R><Y><A><A><R><L><A><A><E><S><S><S><S><Q><P><P><Q><Q><R><S><A><P><D><I><S><F><T><I><D><A><N><K><Q><Q><R><Q><L><I><A><E><L><E><N><K><N><R><E><I><L><Q><E><I><Q><R><L><R><L><E><H><E><Q><A><S><Q><P><T><P><E><K><A><Q><Q><N><P><T><L><L><A><E><L><R><L><L><R><Q><R><K><D><E><L><E><Q><R><M><S><A><L><Q><E><S><R><R><E><L><M><V><Q><L><E><G><L><M><K><L><L><K><T><Q><G><A><G><S><P><R><S><S><P><S><H><T><I><S><R><P><I><P><M><P><I><R><S><A><S><A><C><S><T><P><T><H><T><P><Q><D><S><L><T><G><V><G><G><D><V><Q><E><A><F><A><Q><S><S><R><R><N><L><R><N><D><L><L><V><A><A><D><S><I><T><N><T><M><S><S><L><V><K><E><L><N><S><E><V><G><S><E><T><E><S><N><V><D><S><E><F><A><R><T><Q><F><E><D><L><V><P><S><P><T><S><E><K><A><F><L><A><Q><I><H><A><R><K><P><G><Y><I><H><S><G><A><T><T><S><T><M><R><G><D><M><V><T><E><D><A><D><P><Y><V><Q><P><E><D><E><N><Y><E><N><D><S><V><R><Q><L><E><N><E><L><Q><M><E><E><Y><L><K><Q><K><L><Q><D><E><A><Y><Q><V><S><L><Q><G> | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.<BOP> | Q9Y4J8 |
Q8NGS1 | OR1J4_HUMAN | Olfactory receptor OR9-21 | Homo | <M><K><R><E><N><Q><S><S><V><S><E><F><L><L><L><D><L><P><I><W><P><E><Q><Q><A><V><F><F><T><L><F><L><G><M><Y><L><I><T><V><L><G><N><L><L><I><I><L><L><I><R><L><D><S><H><L><H><T><P><M><F><F><F><L><S><H><L><A><L><T><D><I><S><L><S><S><V><T><V><P><K><M><L><L><S><M><Q><T><Q><D><Q><S><I><L><Y><A><G><C><V><T><Q><M><Y><F><F><I><F><F><T><D><L><D><N><F><L><L><T><S><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><T><T><I><M><K><E><G><L><C><N><L><L><V><T><V><S><W><I><L><S><C><T><N><A><L><S><H><T><L><L><L><A><Q><L><S><F><C><A><D><N><T><I><P><H><F><F><C><D><L><V><A><L><L><K><L><S><C><S><D><I><S><L><N><E><L><V><I><F><T><V><G><Q><A><V><I><T><L><P><L><I><C><I><L><I><S><Y><G><H><I><G><V><T><I><L><K><A><P><S><T><K><G><I><F><K><A><L><S><T><C><G><S><H><L><S><V><V><S><L><Y><Y><G><T><I><I><G><L><Y><F><L><P><S><S><S><A><S><S><D><K><D><V><I><A><S><V><M><Y><T><V><I><T><P><L><L><N><P><F><I><Y><S><L><R><N><R><D><I><K><G><A><L><E><R><L><F><N><R><A><T><V><L><S><Q> | Odorant receptor.<BOP> | Q8NGS1 |
Q8NH67 | O52I2_HUMAN | Olfactory receptor OR11-12 | Homo | <M><C><Q><Q><I><L><R><D><C><I><L><L><I><H><H><L><C><I><N><R><K><K><V><S><L><V><M><L><G><P><A><Y><N><H><T><M><E><T><P><A><S><F><L><L><V><G><I><P><G><L><Q><S><S><H><L><W><L><A><I><S><L><S><A><M><Y><I><I><A><L><L><G><N><T><I><I><V><T><A><I><W><M><D><S><T><R><H><E><P><M><Y><C><F><L><C><V><L><A><A><V><D><I><V><M><A><S><S><V><V><P><K><M><V><S><I><F><C><S><G><D><S><S><I><S><F><S><A><C><F><T><Q><M><F><F><V><H><L><A><T><A><V><E><T><G><L><L><L><T><M><A><F><D><R><Y><V><A><I><C><K><P><L><H><Y><K><R><I><L><T><P><Q><V><M><L><G><M><S><M><A><I><T><I><R><A><I><I><A><I><T><P><L><S><W><M><V><S><H><L><P><F><C><G><S><N><V><V><V><H><S><Y><C><E><H><I><A><L><A><R><L><A><C><A><D><P><V><P><S><S><L><Y><S><L><I><G><S><S><L><M><V><G><S><D><V><A><F><I><A><A><S><Y><I><L><I><L><K><A><V><F><G><L><S><S><K><T><A><Q><L><K><A><L><S><T><C><G><S><H><V><G><V><M><A><L><Y><Y><L><P><G><M><A><S><I><Y><A><A><W><L><G><Q><D><V><V><P><L><H><T><Q><V><L><L><A><D><L><Y><V><I><I><P><A><T><L><N><P><I><I><Y><G><M><R><T><K><Q><L><R><E><R><I><W><S><Y><L><M><H><V><L><F><D><H><S><N><L><G><S> | Odorant receptor.<BOP> | Q8NH67 |
P54619 | AAKG1_HUMAN | 5'-AMP-activated protein kinase subunit gamma-1 | Homo | <M><E><T><V><I><S><S><D><S><S><P><A><V><E><N><E><H><P><Q><E><T><P><E><S><N><N><S><V><Y><T><S><F><M><K><S><H><R><C><Y><D><L><I><P><T><S><S><K><L><V><V><F><D><T><S><L><Q><V><K><K><A><F><F><A><L><V><T><N><G><V><R><A><A><P><L><W><D><S><K><K><Q><S><F><V><G><M><L><T><I><T><D><F><I><N><I><L><H><R><Y><Y><K><S><A><L><V><Q><I><Y><E><L><E><E><H><K><I><E><T><W><R><E><V><Y><L><Q><D><S><F><K><P><L><V><C><I><S><P><N><A><S><L><F><D><A><V><S><S><L><I><R><N><K><I><H><R><L><P><V><I><D><P><E><S><G><N><T><L><Y><I><L><T><H><K><R><I><L><K><F><L><K><L><F><I><T><E><F><P><K><P><E><F><M><S><K><S><L><E><E><L><Q><I><G><T><Y><A><N><I><A><M><V><R><T><T><T><P><V><Y><V><A><L><G><I><F><V><Q><H><R><V><S><A><L><P><V><V><D><E><K><G><R><V><V><D><I><Y><S><K><F><D><V><I><N><L><A><A><E><K><T><Y><N><N><L><D><V><S><V><T><K><A><L><Q><H><R><S><H><Y><F><E><G><V><L><K><C><Y><L><H><E><T><L><E><T><I><I><N><R><L><V><E><A><E><V><H><R><L><V><V><V><D><E><N><D><V><V><K><G><I><V><S><L><S><D><I><L><Q><A><L><V><L><T><G><G><E><K><K><P> | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.<BOP> | P54619 |
P16671 | CD36_HUMAN | Thrombospondin receptor | Homo | <M><G><C><D><R><N><C><G><L><I><A><G><A><V><I><G><A><V><L><A><V><F><G><G><I><L><M><P><V><G><D><L><L><I><Q><K><T><I><K><K><Q><V><V><L><E><E><G><T><I><A><F><K><N><W><V><K><T><G><T><E><V><Y><R><Q><F><W><I><F><D><V><Q><N><P><Q><E><V><M><M><N><S><S><N><I><Q><V><K><Q><R><G><P><Y><T><Y><R><V><R><F><L><A><K><E><N><V><T><Q><D><A><E><D><N><T><V><S><F><L><Q><P><N><G><A><I><F><E><P><S><L><S><V><G><T><E><A><D><N><F><T><V><L><N><L><A><V><A><A><A><S><H><I><Y><Q><N><Q><F><V><Q><M><I><L><N><S><L><I><N><K><S><K><S><S><M><F><Q><V><R><T><L><R><E><L><L><W><G><Y><R><D><P><F><L><S><L><V><P><Y><P><V><T><T><T><V><G><L><F><Y><P><Y><N><N><T><A><D><G><V><Y><K><V><F><N><G><K><D><N><I><S><K><V><A><I><I><D><T><Y><K><G><K><R><N><L><S><Y><W><E><S><H><C><D><M><I><N><G><T><D><A><A><S><F><P><P><F><V><E><K><S><Q><V><L><Q><F><F><S><S><D><I><C><R><S><I><Y><A><V><F><E><S><D><V><N><L><K><G><I><P><V><Y><R><F><V><L><P><S><K><A><F><A><S><P><V><E><N><P><D><N><Y><C><F><C><T><E><K><I><I><S><K><N><C><T><S><Y><G><V><L><D><I><S><K><C><K><E><G><R><P><V><Y><I><S><L><P><H><F><L><Y><A><S><P><D><V><S><E><P><I><D><G><L><N><P><N><E><E><E><H><R><T><Y><L><D><I><E><P><I><T><G><F><T><L><Q><F><A><K><R><L><Q><V><N><L><L><V><K><P><S><E><K><I><Q><V><L><K><N><L><K><R><N><Y><I><V><P><I><L><W><L><N><E><T><G><T><I><G><D><E><K><A><N><M><F><R><S><Q><V><T><G><K><I><N><L><L><G><L><I><E><M><I><L><L><S><V><G><V><V><M><F><V><A><F><M><I><S><Y><C><A><C><R><S><K><T><I><K> | (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.<BOP> | P16671 |
P07992 | ERCC1_HUMAN | DNA excision repair protein ERCC-1 | Homo | <M><D><P><G><K><D><K><E><G><V><P><Q><P><S><G><P><P><A><R><K><K><F><V><I><P><L><D><E><D><E><V><P><P><G><V><A><K><P><L><F><R><S><T><Q><S><L><P><T><V><D><T><S><A><Q><A><A><P><Q><T><Y><A><E><Y><A><I><S><Q><P><L><E><G><A><G><A><T><C><P><T><G><S><E><P><L><A><G><E><T><P><N><Q><A><L><K><P><G><A><K><S><N><S><I><I><V><S><P><R><Q><R><G><N><P><V><L><K><F><V><R><N><V><P><W><E><F><G><D><V><I><P><D><Y><V><L><G><Q><S><T><C><A><L><F><L><S><L><R><Y><H><N><L><H><P><D><Y><I><H><G><R><L><Q><S><L><G><K><N><F><A><L><R><V><L><L><V><Q><V><D><V><K><D><P><Q><Q><A><L><K><E><L><A><K><M><C><I><L><A><D><C><T><L><I><L><A><W><S><P><E><E><A><G><R><Y><L><E><T><Y><K><A><Y><E><Q><K><P><A><D><L><L><M><E><K><L><E><Q><D><F><V><S><R><V><T><E><C><L><T><T><V><K><S><V><N><K><T><D><S><Q><T><L><L><T><T><F><G><S><L><E><Q><L><I><A><A><S><R><E><D><L><A><L><C><P><G><L><G><P><Q><K><A><R><R><L><F><D><V><L><H><E><P><F><L><K><V><P> | Not functional in the nucleotide excision repair pathway.<BOP> | P07992 |
P35813 | PPM1A_HUMAN | Protein phosphatase IA | Homo | <M><G><A><F><L><D><K><P><K><M><E><K><H><N><A><Q><G><Q><G><N><G><L><R><Y><G><L><S><S><M><Q><G><W><R><V><E><M><E><D><A><H><T><A><V><I><G><L><P><S><G><L><E><S><W><S><F><F><A><V><Y><D><G><H><A><G><S><Q><V><A><K><Y><C><C><E><H><L><L><D><H><I><T><N><N><Q><D><F><K><G><S><A><G><A><P><S><V><E><N><V><K><N><G><I><R><T><G><F><L><E><I><D><E><H><M><R><V><M><S><E><K><K><H><G><A><D><R><S><G><S><T><A><V><G><V><L><I><S><P><Q><H><T><Y><F><I><N><C><G><D><S><R><G><L><L><C><R><N><R><K><V><H><F><F><T><Q><D><H><K><P><S><N><P><L><E><K><E><R><I><Q><N><A><G><G><S><V><M><I><Q><R><V><N><G><S><L><A><V><S><R><A><L><G><D><F><D><Y><K><C><V><H><G><K><G><P><T><E><Q><L><V><S><P><E><P><E><V><H><D><I><E><R><S><E><E><D><D><Q><F><I><I><L><A><C><D><G><I><W><D><V><M><G><N><E><E><L><C><D><F><V><R><S><R><L><E><V><T><D><D><L><E><K><V><C><N><E><V><V><D><T><C><L><Y><K><G><S><R><D><N><M><S><V><I><L><I><C><F><P><N><A><P><K><V><S><P><E><A><V><K><K><E><A><E><L><D><K><Y><L><E><C><R><V><E><E><I><I><K><K><Q><G><E><G><V><P><D><L><V><H><V><M><R><T><L><A><S><E><N><I><P><S><L><P><P><G><G><E><L><A><S><K><R><N><V><I><E><A><V><Y><N><R><L><N><P><Y><K><N><D><D><T><D><S><T><S><T><D><D><M><W> | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.<BOP> | P35813 |
P51787 | KCNQ1_HUMAN | Voltage-gated potassium channel subunit Kv7.1 | Homo | <M><A><A><A><S><S><P><P><R><A><E><R><K><R><W><G><W><G><R><L><P><G><A><R><R><G><S><A><G><L><A><K><K><C><P><F><S><L><E><L><A><E><G><G><P><A><G><G><A><L><Y><A><P><I><A><P><G><A><P><G><P><A><P><P><A><S><P><A><A><P><A><A><P><P><V><A><S><D><L><G><P><R><P><P><V><S><L><D><P><R><V><S><I><Y><S><T><R><R><P><V><L><A><R><T><H><V><Q><G><R><V><Y><N><F><L><E><R><P><T><G><W><K><C><F><V><Y><H><F><A><V><F><L><I><V><L><V><C><L><I><F><S><V><L><S><T><I><E><Q><Y><A><A><L><A><T><G><T><L><F><W><M><E><I><V><L><V><V><F><F><G><T><E><Y><V><V><R><L><W><S><A><G><C><R><S><K><Y><V><G><L><W><G><R><L><R><F><A><R><K><P><I><S><I><I><D><L><I><V><V><V><A><S><M><V><V><L><C><V><G><S><K><G><Q><V><F><A><T><S><A><I><R><G><I><R><F><L><Q><I><L><R><M><L><H><V><D><R><Q><G><G><T><W><R><L><L><G><S><V><V><F><I><H><R><Q><E><L><I><T><T><L><Y><I><G><F><L><G><L><I><F><S><S><Y><F><V><Y><L><A><E><K><D><A><V><N><E><S><G><R><V><E><F><G><S><Y><A><D><A><L><W><W><G><V><V><T><V><T><T><I><G><Y><G><D><K><V><P><Q><T><W><V><G><K><T><I><A><S><C><F><S><V><F><A><I><S><F><F><A><L><P><A><G><I><L><G><S><G><F><A><L><K><V><Q><Q><K><Q><R><Q><K><H><F><N><R><Q><I><P><A><A><A><S><L><I><Q><T><A><W><R><C><Y><A><A><E><N><P><D><S><S><T><W><K><I><Y><I><R><K><A><P><R><S><H><T><L><L><S><P><S><P><K><P><K><K><S><V><V><V><K><K><K><K><F><K><L><D><K><D><N><G><V><T><P><G><E><K><M><L><T><V><P><H><I><T><C><D><P><P><E><E><R><R><L><D><H><F><S><V><D><G><Y><D><S><S><V><R><K><S><P><T><L><L><E><V><S><M><P><H><F><M><R><T><N><S><F><A><E><D><L><D><L><E><G><E><T><L><L><T><P><I><T><H><I><S><Q><L><R><E><H><H><R><A><T><I><K><V><I><R><R><M><Q><Y><F><V><A><K><K><K><F><Q><Q><A><R><K><P><Y><D><V><R><D><V><I><E><Q><Y><S><Q><G><H><L><N><L><M><V><R><I><K><E><L><Q><R><R><L><D><Q><S><I><G><K><P><S><L><F><I><S><V><S><E><K><S><K><D><R><G><S><N><T><I><G><A><R><L><N><R><V><E><D><K><V><T><Q><L><D><Q><R><L><A><L><I><T><D><M><L><H><Q><L><L><S><L><H><G><G><S><T><P><G><S><G><G><P><P><R><E><G><G><A><H><I><T><Q><P><C><G><S><G><G><S><V><D><P><E><L><F><L><P><S><N><T><L><P><T><Y><E><Q><L><T><V><P><R><R><G><P><D><E><G><S> | Non-functional alone but modulatory when coexpressed with the full-length isoform 1.<BOP> | P51787 |
O95150 | TNF15_HUMAN | Tumor necrosis factor ligand superfamily member 15, secreted form | Homo | <M><A><E><D><L><G><L><S><F><G><E><T><A><S><V><E><M><L><P><E><H><G><S><C><R><P><K><A><R><S><S><S><A><R><W><A><L><T><C><C><L><V><L><L><P><F><L><A><G><L><T><T><Y><L><L><V><S><Q><L><R><A><Q><G><E><A><C><V><Q><F><Q><A><L><K><G><Q><E><F><A><P><S><H><Q><Q><V><Y><A><P><L><R><A><D><G><D><K><P><R><A><H><L><T><V><V><R><Q><T><P><T><Q><H><F><K><N><Q><F><P><A><L><H><W><E><H><E><L><G><L><A><F><T><K><N><R><M><N><Y><T><N><K><F><L><L><I><P><E><S><G><D><Y><F><I><Y><S><Q><V><T><F><R><G><M><T><S><E><C><S><E><I><R><Q><A><G><R><P><N><K><P><D><S><I><T><V><V><I><T><K><V><T><D><S><Y><P><E><P><T><Q><L><L><M><G><T><K><S><V><C><E><V><G><S><N><W><F><Q><P><I><Y><L><G><A><M><F><S><L><Q><E><G><D><K><L><M><V><N><V><S><D><I><S><L><V><D><Y><T><K><E><D><K><T><F><F><G><A><F><L><L> | Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.<BOP> | O95150 |
Q86YB8 | ERO1B_HUMAN | Oxidoreductin-1-L-beta | Homo | <M><S><Q><G><V><R><R><A><G><A><G><Q><G><V><A><A><A><V><Q><L><L><V><T><L><S><F><L><R><S><V><V><E><A><Q><V><T><G><V><L><D><D><C><L><C><D><I><D><S><I><D><N><F><N><T><Y><K><I><F><P><K><I><K><K><L><Q><E><R><D><Y><F><R><Y><Y><K><V><N><L><K><R><P><C><P><F><W><A><E><D><G><H><C><S><I><K><D><C><H><V><E><P><C><P><E><S><K><I><P><V><G><I><K><A><G><H><S><N><K><Y><L><K><M><A><N><N><T><K><E><L><E><D><C><E><Q><A><N><K><L><G><A><I><N><S><T><L><S><N><Q><S><K><E><A><F><I><D><W><A><R><Y><D><D><S><R><D><H><F><C><E><L><D><D><E><R><S><P><A><A><Q><Y><V><D><L><L><L><N><P><E><R><Y><T><G><Y><K><G><T><S><A><W><R><V><W><N><S><I><Y><E><E><N><C><F><K><P><R><S><V><Y><R><P><L><N><P><L><A><P><S><R><G><E><D><D><G><E><S><F><Y><T><W><L><E><G><L><C><L><E><K><R><V><F><Y><K><L><I><S><G><L><H><A><S><I><N><L><H><L><C><A><N><Y><L><L><E><E><T><W><G><K><P><S><W><G><P><N><I><K><E><F><K><H><R><F><D><P><V><E><T><K><G><E><G><P><R><R><L><K><N><L><Y><F><L><Y><L><I><E><L><R><A><L><S><K><V><A><P><Y><F><E><R><S><I><V><D><L><Y><T><G><N><A><E><E><D><A><D><T><K><T><L><L><L><N><I><F><Q><D><T><K><S><F><P><M><H><F><D><E><K><S><M><F><A><G><D><K><K><G><A><K><S><L><K><E><E><F><R><L><H><F><K><N><I><S><R><I><M><D><C><V><G><C><D><K><C><R><L><W><G><K><L><Q><T><Q><G><L><G><T><A><L><K><I><L><F><S><E><K><E><I><Q><K><L><P><E><N><S><P><S><K><G><F><Q><L><T><R><Q><E><I><V><A><L><L><N><A><F><G><R><L><S><T><S><I><R><D><L><Q><N><F><K><V><L><L><Q><H><S><R> | Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.<BOP> | Q86YB8 |
Q9GZU8 | PIP30_HUMAN | PA28G-interacting protein | Homo | <M><D><G><G><D><D><G><N><L><I><I><K><K><R><F><V><S><E><A><E><L><D><E><R><R><K><R><R><Q><E><E><W><E><K><V><R><K><P><E><D><P><E><E><C><P><E><E><V><Y><D><P><R><S><L><Y><E><R><L><Q><E><Q><K><D><R><K><Q><Q><E><Y><E><E><Q><F><K><F><K><N><M><V><R><G><L><D><E><D><E><T><N><F><L><D><E><V><S><R><Q><Q><E><L><I><E><K><Q><R><R><E><E><E><L><K><E><L><K><E><Y><R><N><N><L><K><K><V><G><I><S><Q><E><N><K><K><E><V><E><K><K><L><T><V><K><P><I><E><T><K><N><K><F><S><Q><A><K><L><L><A><G><A><V><K><H><K><S><S><E><S><G><N><S><V><K><R><L><K><P><D><P><E><P><D><D><K><N><Q><E><P><S><S><C><K><S><L><G><N><T><S><L><S><G><P><S><I><H><C><P><S><A><A><V><C><I><G><I><L><P><G><L><G><A><Y><S><G><S><S><D><S><E><S><S><S><D><S><E><G><T><I><N><A><T><G><K><I><V><S><S><I><F><R><T><N><T><F><L><E><A><P> | Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus.<BOP> | Q9GZU8 |
Q9UHY7 | ENOPH_HUMAN | MASA homolog | Homo | <M><V><V><L><S><V><P><A><E><V><T><V><I><L><L><D><I><E><G><T><T><T><P><I><A><F><V><K><D><I><L><F><P><Y><I><E><E><N><V><K><E><Y><L><Q><T><H><W><E><E><E><E><C><Q><Q><D><V><S><L><L><R><K><Q><A><E><E><D><A><H><L><D><G><A><V><P><I><P><A><A><S><G><N><G><V><D><D><L><Q><Q><M><I><Q><A><V><V><D><N><V><C><W><Q><M><S><L><D><R><K><T><T><A><L><K><Q><L><Q><G><H><M><W><R><A><A><F><T><A><G><R><M><K><A><E><F><F><A><D><V><V><P><A><V><R><K><W><R><E><A><G><M><K><V><Y><I><Y><S><S><G><S><V><E><A><Q><K><L><L><F><G><H><S><T><E><G><D><I><L><E><L><V><D><G><H><F><D><T><K><I><G><H><K><V><E><S><E><S><Y><R><K><I><A><D><S><I><G><C><S><T><N><N><I><L><F><L><T><D><V><T><R><E><A><S><A><A><E><E><A><D><V><H><V><A><V><V><V><R><P><G><N><A><G><L><T><D><D><E><K><T><Y><Y><S><L><I><T><S><F><S><E><L><Y><L><P><S><S><T> | Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).<BOP> | Q9UHY7 |
Q9UII2 | ATIF1_HUMAN | Inhibitor of F(1)F(o)-ATPase | Homo | <M><A><V><T><A><L><A><A><R><T><W><L><G><V><W><G><V><R><T><M><Q><A><R><G><F><G><S><D><Q><S><E><N><V><D><R><G><A><G><S><I><R><E><A><G><G><A><F><G><K><R><E><Q><A><E><E><E><R><Y><F><R><A><Q><S><R><E><Q><L><A><A><L><K><K><H><H><E><E><E><I><V><H><H><K><K><E><I><E><R><L><Q><K><E><I><E><R><H><K><Q><K><I><K><M><L><K><H><D><D> | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.<BOP> | Q9UII2 |
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