accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q9Y278
HS3S2_HUMAN
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
Homo
<M><A><Y><R><V><L><G><R><A><G><P><P><Q><P><R><R><A><R><R><L><L><F><A><F><T><L><S><L><S><C><T><Y><L><C><Y><S><F><L><C><C><C><D><D><L><G><R><S><R><L><L><G><A><P><R><C><L><R><G><P><S><A><G><G><Q><K><L><L><Q><K><S><R><P><C><D><P><S><G><P><T><P><S><E><P><S><A><P><S><A><P><A><A><A><V><P><A><P><R><L><S><G><S><N><H><S><G><S><P><K><L><G><T><K><R><L><P><Q><A><L><I><V><G><V><K><K><G><G><T><R><A><V><L><E><F><I><R><V><H><P><D><V><R><A><L><G><T><E><P><H><F><F><D><R><N><Y><G><R><G><L><D><W><Y><R><S><L><M><P><R><T><L><E><S><Q><I><T><L><E><K><T><P><S><Y><F><V><T><Q><E><A><P><R><R><I><F><N><M><S><R><D><T><K><L><I><V><V><V><R><N><P><V><T><R><A><I><S><D><Y><T><Q><T><L><S><K><K><P><D><I><P><T><F><E><G><L><S><F><R><N><R><T><L><G><L><V><D><V><S><W><N><A><I><R><I><G><M><Y><V><L><H><L><E><S><W><L><Q><Y><F><P><L><A><Q><I><H><F><V><S><G><E><R><L><I><T><D><P><A><G><E><M><G><R><V><Q><D><F><L><G><I><K><R><F><I><T><D><K><H><F><Y><F><N><K><T><K><G><F><P><C><L><K><K><T><E><S><S><L><L><P><R><C><L><G><K><S><K><G><R><T><H><V><Q><I><D><P><E><V><I><D><Q><L><R><E><F><Y><R><P><Y><N><I><K><F><Y><E><T><V><G><Q><D><F><R><W><E>
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate . Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS . Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate .<BOP>
Q9Y278
Q9Y696
CLIC4_HUMAN
Intracellular chloride ion channel protein p64H1
Homo
<M><A><L><S><M><P><L><N><G><L><K><E><E><D><K><E><P><L><I><E><L><F><V><K><A><G><S><D><G><E><S><I><G><N><C><P><F><S><Q><R><L><F><M><I><L><W><L><K><G><V><V><F><S><V><T><T><V><D><L><K><R><K><P><A><D><L><Q><N><L><A><P><G><T><H><P><P><F><I><T><F><N><S><E><V><K><T><D><V><N><K><I><E><E><F><L><E><E><V><L><C><P><P><K><Y><L><K><L><S><P><K><H><P><E><S><N><T><A><G><M><D><I><F><A><K><F><S><A><Y><I><K><N><S><R><P><E><A><N><E><A><L><E><R><G><L><L><K><T><L><Q><K><L><D><E><Y><L><N><S><P><L><P><D><E><I><D><E><N><S><M><E><D><I><K><F><S><T><R><K><F><L><D><G><N><E><M><T><L><A><D><C><N><L><L><P><K><L><H><I><V><K><V><V><A><K><K><Y><R><N><F><D><I><P><K><E><M><T><G><I><W><R><Y><L><T><N><A><Y><S><R><D><E><F><T><N><T><C><P><S><D><K><E><V><E><I><A><Y><S><D><V><A><K><R><L><T><K>
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).<BOP>
Q9Y696
Q9ULP9
TBC24_HUMAN
TBC1 domain family member 24
Homo
<M><D><S><P><G><Y><N><C><F><V><D><K><D><K><M><D><A><A><I><Q><D><L><G><P><K><E><L><S><C><T><E><L><Q><E><L><K><Q><L><A><R><Q><G><Y><W><A><Q><S><H><A><L><R><G><K><V><Y><Q><R><L><I><R><D><I><P><C><R><T><V><T><P><D><A><S><V><Y><S><D><I><V><G><K><I><V><G><K><H><S><S><S><C><L><P><L><P><E><F><V><D><N><T><Q><V><P><S><Y><C><L><N><A><R><G><E><G><A><V><R><K><I><L><L><C><L><A><N><Q><F><P><D><I><S><F><C><P><A><L><P><A><V><V><A><L><L><L><H><Y><S><I><D><E><A><E><C><F><E><K><A><C><R><I><L><A><C><N><D><P><G><R><R><L><I><D><Q><S><F><L><A><F><E><S><S><C><M><T><F><G><D><L><V><N><K><Y><C><Q><A><A><H><K><L><M><V><A><V><S><E><D><V><L><Q><V><Y><A><D><W><Q><R><W><L><F><G><E><L><P><L><C><Y><F><A><R><V><F><D><V><F><L><V><E><G><Y><K><V><L><Y><R><V><A><L><A><I><L><K><F><F><H><K><V><R><A><G><Q><P><L><E><S><D><S><V><K><Q><D><I><R><T><F><V><R><D><I><A><K><T><V><S><P><E><K><L><L><E><K><A><F><A><I><R><L><F><S><R><K><E><I><Q><L><L><Q><M><A><N><E><K><A><L><K><Q><K><G><I><T><V><K><Q><K><S><V><S><L><S><K><R><Q><F><V><H><L><A><V><H><A><E><N><F><R><S><E><I><V><S><V><R><E><M><R><D><I><W><S><W><V><P><E><R><F><A><L><C><Q><P><L><L><L><F><S><S><L><Q><H><G><Y><S><L><A><R><F><Y><F><Q><C><E><G><H><E><P><T><L><L><L><I><K><T><T><Q><K><E><V><C><G><A><Y><L><S><T><D><W><S><E><R><N><K><F><G><G><K><L><G><F><F><G><T><G><E><C><F><V><F><R><L><Q><P><E><V><Q><R><Y><E><W><V><V><I><K><H><P><E><L><T><K><P><P><P><L><M><A><A><E><P><T><A><P><L><S><H><S><A><S><S><D><P><A><D><R><L><S><P><F><L><A><A><R><H><F><N><L><P><S><K><T><E><S><M><F><M><A><G><G><S><D><C><L><I><V><G><G><G><G><G><Q><A><L><Y><I><D><G><D><L><N><R><G><R><T><S><H><C><D><T><F><N><N><Q><P><L><C><S><E><N><F><L><I><A><A><V><E><A><W><G><F><Q><D><P><D><T><Q>
May act as a GTPase-activating protein for Rab family protein(s) . Involved in neuronal projections development, probably through a negative modulation of ARF6 function . Involved in the regulation of synaptic vesicle trafficking .<BOP>
Q9ULP9
Q9UMX0
UBQL1_HUMAN
Protein linking IAP with cytoskeleton 1
Homo
<M><A><E><S><G><E><S><G><G><P><P><G><S><Q><D><S><A><A><G><A><E><G><A><G><A><P><A><A><A><A><S><A><E><P><K><I><M><K><V><T><V><K><T><P><K><E><K><E><E><F><A><V><P><E><N><S><S><V><Q><Q><F><K><E><E><I><S><K><R><F><K><S><H><T><D><Q><L><V><L><I><F><A><G><K><I><L><K><D><Q><D><T><L><S><Q><H><G><I><H><D><G><L><T><V><H><L><V><I><K><T><Q><N><R><P><Q><D><H><S><A><Q><Q><T><N><T><A><G><S><N><V><T><T><S><S><T><P><N><S><N><S><T><S><G><S><A><T><S><N><P><F><G><L><G><G><L><G><G><L><A><G><L><S><S><L><G><L><N><T><T><N><F><S><E><L><Q><S><Q><M><Q><R><Q><L><L><S><N><P><E><M><M><V><Q><I><M><E><N><P><F><V><Q><S><M><L><S><N><P><D><L><M><R><Q><L><I><M><A><N><P><Q><M><Q><Q><L><I><Q><R><N><P><E><I><S><H><M><L><N><N><P><D><I><M><R><Q><T><L><E><L><A><R><N><P><A><M><M><Q><E><M><M><R><N><Q><D><R><A><L><S><N><L><E><S><I><P><G><G><Y><N><A><L><R><R><M><Y><T><D><I><Q><E><P><M><L><S><A><A><Q><E><Q><F><G><G><N><P><F><A><S><L><V><S><N><T><S><S><G><E><G><S><Q><P><S><R><T><E><N><R><D><P><L><P><N><P><W><A><P><Q><T><S><Q><S><S><S><A><S><S><G><T><A><S><T><V><G><G><T><T><G><S><T><A><S><G><T><S><G><Q><S><T><T><A><P><N><L><V><P><G><V><G><A><S><M><F><N><T><P><G><M><Q><S><L><L><Q><Q><I><T><E><N><P><Q><L><M><Q><N><M><L><S><A><P><Y><M><R><S><M><M><Q><S><L><S><Q><N><P><D><L><A><A><Q><M><M><L><N><N><P><L><F><A><G><N><P><Q><L><Q><E><Q><M><R><Q><Q><L><P><T><F><L><Q><Q><M><Q><N><P><D><T><L><S><A><M><S><N><P><R><A><M><Q><A><L><L><Q><I><Q><Q><G><L><Q><T><L><A><T><E><A><P><G><L><I><P><G><F><T><P><G><L><G><A><L><G><S><T><G><G><S><S><G><T><N><G><S><N><A><T><P><S><E><N><T><S><P><T><A><G><T><T><E><P><G><H><Q><Q><F><I><Q><Q><M><L><Q><A><L><A><G><V><N><P><Q><L><Q><N><P><E><V><R><F><Q><Q><Q><L><E><Q><L><S><A><M><G><F><L><N><R><E><A><N><L><Q><A><L><I><A><T><G><G><D><I><N><A><A><I><E><R><L><L><G><S><Q><P><S>
Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress . Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis .<BOP>
Q9UMX0
Q9NWW9
PLAT2_HUMAN
HRAS-like suppressor 2
Homo
<M><A><L><A><R><P><R><P><R><L><G><D><L><I><E><I><S><R><F><G><Y><A><H><W><A><I><Y><V><G><D><G><Y><V><V><H><L><A><P><A><S><E><I><A><G><A><G><A><A><S><V><L><S><A><L><T><N><K><A><I><V><K><K><E><L><L><S><V><V><A><G><G><D><N><Y><R><V><N><N><K><H><D><D><R><Y><T><P><L><P><S><N><K><I><V><K><R><A><E><E><L><V><G><Q><E><L><P><Y><S><L><T><S><D><N><C><E><H><F><V><N><H><L><R><Y><G><V><S><R><S><D><Q><V><T><G><A><V><T><T><V><G><V><A><A><G><L><L><A><A><A><S><L><V><G><I><L><L><A><R><S><K><R><E><R><Q>
Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) . Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor . Exhibits
Q9NWW9
Q02930
CREB5_HUMAN
cAMP-response element-binding protein A
Homo
<M><I><Y><E><E><S><K><M><N><L><E><Q><E><R><P><F><V><C><S><A><P><G><C><S><Q><R><F><P><T><E><D><H><L><M><I><H><R><H><K><H><E><M><T><L><K><F><P><S><I><K><T><D><N><M><L><S><D><Q><T><P><T><P><T><R><F><L><K><N><C><E><E><V><G><L><F><S><E><L><D><C><S><L><E><H><E><F><R><K><A><Q><E><E><E><S><S><K><R><N><I><S><M><H><N><A><V><G><G><A><M><T><G><P><G><T><H><Q><L><S><S><A><R><L><P><N><H><D><T><N><V><V><I><Q><Q><A><M><P><S><P><Q><S><S><S><V><I><T><Q><A><P><S><T><N><R><Q><I><G><P><V><P><G><S><L><S><S><L><L><H><L><H><N><R><Q><R><Q><P><M><P><A><S><M><P><G><T><L><P><N><P><T><M><P><G><S><S><A><V><L><M><P><M><E><R><Q><M><S><V><N><S><S><I><M><G><M><Q><G><P><N><L><S><N><P><C><A><S><P><Q><V><Q><P><M><H><S><E><A><K><M><R><L><K><A><A><L><T><H><H><P><A><A><M><S><N><G><N><M><N><T><M><G><H><M><M><E><M><M><G><S><R><Q><D><Q><T><P><H><H><H><M><H><S><H><P><H><Q><H><Q><T><L><P><P><H><H><P><Y><P><H><Q><H><Q><H><P><A><H><H><P><H><P><Q><P><H><H><Q><Q><N><H><P><H><H><H><S><H><S><H><L><H><A><H><P><A><H><H><Q><T><S><P><H><P><P><L><H><T><G><N><Q><A><Q><V><S><P><A><T><Q><Q><M><Q><P><T><Q><T><I><Q><P><P><Q><P><T><G><G><R><R><R><R><V><V><D><E><D><P><D><E><R><R><R><K><F><L><E><R><N><R><A><A><A><T><R><C><R><Q><K><R><K><V><W><V><M><S><L><E><K><K><A><E><E><L><T><Q><T><N><M><Q><L><Q><N><E><V><S><M><L><K><N><E><V><A><Q><L><K><Q><L><L><L><T><H><K><D><C><P><I><T><A><M><Q><K><E><S><Q><G><Y><L><S><P><E><S><S><P><P><A><S><P><V><P><A><C><S><Q><Q><Q><V><I><Q><H><N><T><I><T><T><S><S><S><V><S><E><V><V><G><S><S><T><L><S><Q><L><T><T><H><R><T><D><L><N><P><I><L>
Binds to the cAMP response element and activates transcription.<BOP>
Q02930
Q53H96
P5CR3_HUMAN
Pyrroline-5-carboxylate reductase-like protein
Homo
<M><A><A><A><E><P><S><P><R><R><V><G><F><V><G><A><G><R><M><A><G><A><I><A><Q><G><L><I><R><A><G><K><V><E><A><Q><H><I><L><A><S><A><P><T><D><R><N><L><C><H><F><Q><A><L><G><C><R><T><T><H><S><N><Q><E><V><L><Q><S><C><L><L><V><I><F><A><T><K><P><H><V><L><P><A><V><L><A><E><V><A><P><V><V><T><T><E><H><I><L><V><S><V><A><A><G><V><S><L><S><T><L><E><E><L><L><P><P><N><T><R><V><L><R><V><L><P><N><L><P><C><V><V><Q><E><G><A><I><V><M><A><R><G><R><H><V><G><S><S><E><T><K><L><L><Q><H><L><L><E><A><C><G><R><C><E><E><V><P><E><A><Y><V><D><I><H><T><G><L><S><G><S><G><V><A><F><V><C><A><F><S><E><A><L><A><E><G><A><V><K><M><G><M><P><S><S><L><A><H><R><I><A><A><Q><T><L><L><G><T><A><K><M><L><L><H><E><G><Q><H><P><A><Q><L><R><S><D><V><C><T><P><G><G><T><T><I><Y><G><L><H><A><L><E><Q><G><G><L><R><A><A><T><M><S><A><V><E><A><A><T><C><R><A><K><E><L><S><R><K>
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.<BOP>
Q53H96
Q8TC57
M1AP_HUMAN
Spermatogenesis-associated protein 37
Homo
<M><H><P><G><R><T><T><G><K><G><P><S><T><H><T><Q><I><D><Q><Q><P><P><R><L><L><I><V><H><I><A><L><P><S><W><A><D><I><C><T><N><L><C><E><A><L><Q><N><F><F><S><L><A><C><S><L><M><G><P><S><R><M><S><L><F><S><L><Y><M><V><Q><D><Q><H><E><C><I><L><P><F><V><Q><V><K><G><N><F><A><R><L><Q><T><C><I><S><E><L><R><M><L><Q><R><E><G><C><F><R><S><Q><G><A><S><L><R><L><A><V><E><D><G><L><Q><Q><F><K><Q><Y><S><R><H><V><T><T><R><A><A><L><T><Y><T><S><L><E><I><T><I><L><T><S><Q><P><G><K><E><V><V><K><Q><L><E><E><G><L><K><D><T><D><L><A><R><V><R><R><F><Q><V><V><E><V><T><K><G><I><L><E><H><V><D><S><A><S><P><V><E><D><T><S><N><D><E><S><S><I><L><G><T><D><I><D><L><Q><T><I><D><N><D><I><V><S><M><E><I><F><F><K><A><W><L><H><N><S><G><T><D><Q><E><Q><I><H><L><L><L><S><S><Q><C><F><S><N><I><S><R><P><R><D><N><P><M><C><L><K><C><D><L><Q><E><R><L><L><C><P><S><L><L><A><G><T><A><D><G><S><L><R><M><D><D><P><K><G><D><F><I><T><L><Y><Q><M><A><S><Q><S><S><A><S><H><Y><K><L><Q><V><I><K><A><L><K><S><S><G><L><C><E><S><L><T><Y><G><L><P><F><I><L><R><P><T><S><C><W><Q><L><D><W><D><E><L><E><T><N><Q><Q><H><F><H><A><L><C><H><S><L><L><K><R><E><W><L><L><L><A><K><G><E><P><P><G><P><G><H><S><Q><R><I><P><A><S><T><F><Y><V><I><M><P><S><H><S><L><T><L><L><V><K><A><V><A><T><R><E><L><M><L><P><S><T><F><P><L><L><P><E><D><P><H><D><D><S><L><K><N><V><E><S><M><L><D><S><L><E><L><E><P><T><Y><N><P><L><H><V><Q><S><H><L><Y><S><H><L><S><S><I><Y><A><K><P><Q><G><R><L><H><P><H><W><E><S><R><A><P><R><K><H><P><C><K><T><G><Q><L><Q><T><N><R><A><R><A><T><V><A><P><L><P><M><T><P><V><P><G><R><A><S><K><M><P><A><A><S><K><S><S><S><D><A><F><F><L><P><S><E><W><E><K><D><P><S><R><P>
Required for meiosis I progression during spermatogenesis.<BOP>
Q8TC57
Q00613
HSF1_HUMAN
Heat shock transcription factor 1
Homo
<M><D><L><P><V><G><P><G><A><A><G><P><S><N><V><P><A><F><L><T><K><L><W><T><L><V><S><D><P><D><T><D><A><L><I><C><W><S><P><S><G><N><S><F><H><V><F><D><Q><G><Q><F><A><K><E><V><L><P><K><Y><F><K><H><N><N><M><A><S><F><V><R><Q><L><N><M><Y><G><F><R><K><V><V><H><I><E><Q><G><G><L><V><K><P><E><R><D><D><T><E><F><Q><H><P><C><F><L><R><G><Q><E><Q><L><L><E><N><I><K><R><K><V><T><S><V><S><T><L><K><S><E><D><I><K><I><R><Q><D><S><V><T><K><L><L><T><D><V><Q><L><M><K><G><K><Q><E><C><M><D><S><K><L><L><A><M><K><H><E><N><E><A><L><W><R><E><V><A><S><L><R><Q><K><H><A><Q><Q><Q><K><V><V><N><K><L><I><Q><F><L><I><S><L><V><Q><S><N><R><I><L><G><V><K><R><K><I><P><L><M><L><N><D><S><G><S><A><H><S><M><P><K><Y><S><R><Q><F><S><L><E><H><V><H><G><S><G><P><Y><S><A><P><S><P><A><Y><S><S><S><S><L><Y><A><P><D><A><V><A><S><S><G><P><I><I><S><D><I><T><E><L><A><P><A><S><P><M><A><S><P><G><G><S><I><D><E><R><P><L><S><S><S><P><L><V><R><V><K><E><E><P><P><S><P><P><Q><S><P><R><V><E><E><A><S><P><G><R><P><S><S><V><D><T><L><L><S><P><T><A><L><I><D><S><I><L><R><E><S><E><P><A><P><A><S><V><T><A><L><T><D><A><R><G><H><T><D><T><E><G><R><P><P><S><P><P><P><T><S><T><P><E><K><C><L><S><V><A><C><L><D><K><N><E><L><S><D><H><L><D><A><M><D><S><N><L><D><N><L><Q><T><M><L><S><S><H><G><F><S><V><D><T><S><A><L><L><D><L><F><S><P><S><V><T><V><P><D><M><S><L><P><D><L><D><S><S><L><A><S><I><Q><E><L><L><S><P><Q><E><P><P><R><P><P><E><A><E><N><S><S><P><D><S><G><K><Q><L><V><H><Y><T><A><Q><P><L><F><L><L><D><P><G><S><V><D><T><G><S><N><D><L><P><V><L><F><E><L><G><E><G><S><Y><F><S><E><G><D><G><F><A><E><D><P><T><I><S><L><L><T><G><S><E><P><P><K><A><K><D><P><T><V><S>
(Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300.<BOP>
Q00613
Q8NHA8
OR1FC_HUMAN
Hs6M1-35P
Homo
<M><E><G><K><N><Q><T><N><I><S><E><F><L><L><L><G><F><S><S><W><Q><Q><Q><Q><V><L><L><F><A><L><F><L><C><L><Y><L><T><G><L><F><G><N><L><L><I><L><L><A><I><G><S><D><H><C><L><H><T><P><M><Y><F><F><L><A><N><L><S><L><V><D><L><C><L><P><S><A><T><V><P><K><M><L><L><N><I><Q><T><Q><T><Q><T><I><S><Y><P><G><C><L><A><Q><M><Y><F><C><M><M><F><A><N><M><D><N><F><L><L><T><V><M><A><Y><D><R><Y><V><A><I><C><H><P><L><H><Y><S><T><I><M><A><L><R><L><C><A><S><L><V><A><A><P><W><V><I><A><I><L><N><P><L><L><H><T><L><M><M><A><H><L><H><F><C><S><D><N><V><I><H><H><F><F><C><D><I><N><S><L><L><P><L><S><C><S><D><T><S><L><N><Q><L><S><V><L><A><T><V><G><L><I><F><V><V><P><S><V><C><I><L><V><S><Y><I><L><I><V><S><A><V><M><K><V><P><S><A><Q><G><K><L><K><A><F><S><T><C><G><S><H><L><A><L><V><I><L><F><Y><G><A><I><T><G><V><Y><M><S><P><L><S><N><H><S><T><E><K><D><S><A><A><S><V><I><F><M><V><V><A><P><V><L><N><P><F><I><Y><S><L><R><N><N><E><L><K><G><T><L><K><K><T><L><S><R><P><G><A><V><A><H><A><C><N><P><S><T><L><G><G><R><G><G><W><I><M><R><S><G><D><R><D><H><P><G>
Odorant receptor.<BOP>
Q8NHA8
Q8NEY3
SPAT4_HUMAN
Testis spermatocyte apoptosis-related gene 2 protein
Homo
<M><A><A><A><G><Q><E><K><G><Y><L><T><Q><T><A><A><A><L><D><K><S><P><S><L><S><P><Q><L><A><A><P><I><R><G><R><P><K><K><C><L><V><Y><P><H><A><P><K><S><S><R><L><S><R><S><V><L><R><W><L><Q><G><L><D><L><S><F><F><P><R><N><I><N><R><D><F><S><N><G><F><L><I><A><E><I><F><C><I><Y><Y><P><W><E><L><E><L><S><S><F><E><N><G><T><S><L><K><V><K><L><D><N><W><A><Q><L><E><K><F><L><A><R><K><K><F><K><L><P><K><E><L><I><H><G><T><I><H><C><K><A><G><V><P><E><I><L><I><E><E><V><Y><T><L><L><T><H><R><E><I><K><S><I><Q><D><D><F><V><N><F><T><D><Y><S><Y><Q><M><R><L><P><L><V><S><R><S><T><V><S><K><S><I><K><D><N><I><R><L><S><E><L><L><S><N><P><N><M><L><T><N><E><L><K><A><E><F><L><I><L><L><H><M><L><Q><R><K><L><G><R><K><L><N><P><E><W><F><D><V><K><P><T><V><G><E><V><T><L><N><H><L><P><A><Q><A><S><G><R><R><Y><N><L><K><V><K><R><G><R><V><V><P><V><L><P><N><I><G><S><G><G><S><S><H><R><E><I><H><V><K><Q><A><G><Q><H><S><Y><Y><S><A><M><K><P><I><R><N><M><D><K><K><P>
May play a role in apoptosis regulation.<BOP>
Q8NEY3
P20160
CAP7_HUMAN
Heparin-binding protein
Homo
<M><T><R><L><T><V><L><A><L><L><A><G><L><L><A><S><S><R><A><G><S><S><P><L><L><D><I><V><G><G><R><K><A><R><P><R><Q><F><P><F><L><A><S><I><Q><N><Q><G><R><H><F><C><G><G><A><L><I><H><A><R><F><V><M><T><A><A><S><C><F><Q><S><Q><N><P><G><V><S><T><V><V><L><G><A><Y><D><L><R><R><R><E><R><Q><S><R><Q><T><F><S><I><S><S><M><S><E><N><G><Y><D><P><Q><Q><N><L><N><D><L><M><L><L><Q><L><D><R><E><A><N><L><T><S><S><V><T><I><L><P><L><P><L><Q><N><A><T><V><E><A><G><T><R><C><Q><V><A><G><W><G><S><Q><R><S><G><G><R><L><S><R><F><P><R><F><V><N><V><T><V><T><P><E><D><Q><C><R><P><N><N><V><C><T><G><V><L><T><R><R><G><G><I><C><N><G><D><G><G><T><P><L><V><C><E><G><L><A><H><G><V><A><S><F><S><L><G><P><C><G><R><G><P><D><F><F><T><R><V><A><L><F><R><D><W><I><D><G><V><L><N><N><P><G><P><G><P><A>
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 331
P20160
P35408
PE2R4_HUMAN
Prostanoid EP4 receptor
Homo
<M><S><T><P><G><V><N><S><S><A><S><L><S><P><D><R><L><N><S><P><V><T><I><P><A><V><M><F><I><F><G><V><V><G><N><L><V><A><I><V><V><L><C><K><S><R><K><E><Q><K><E><T><T><F><Y><T><L><V><C><G><L><A><V><T><D><L><L><G><T><L><L><V><S><P><V><T><I><A><T><Y><M><K><G><Q><W><P><G><G><Q><P><L><C><E><Y><S><T><F><I><L><L><F><F><S><L><S><G><L><S><I><I><C><A><M><S><V><E><R><Y><L><A><I><N><H><A><Y><F><Y><S><H><Y><V><D><K><R><L><A><G><L><T><L><F><A><V><Y><A><S><N><V><L><F><C><A><L><P><N><M><G><L><G><S><S><R><L><Q><Y><P><D><T><W><C><F><I><D><W><T><T><N><V><T><A><H><A><A><Y><S><Y><M><Y><A><G><F><S><S><F><L><I><L><A><T><V><L><C><N><V><L><V><C><G><A><L><L><R><M><H><R><Q><F><M><R><R><T><S><L><G><T><E><Q><H><H><A><A><A><A><A><S><V><A><S><R><G><H><P><A><A><S><P><A><L><P><R><L><S><D><F><R><R><R><R><S><F><R><R><I><A><G><A><E><I><Q><M><V><I><L><L><I><A><T><S><L><V><V><L><I><C><S><I><P><L><V><V><R><V><F><V><N><Q><L><Y><Q><P><S><L><E><R><E><V><S><K><N><P><D><L><Q><A><I><R><I><A><S><V><N><P><I><L><D><P><W><I><Y><I><L><L><R><K><T><V><L><S><K><A><I><E><K><I><K><C><L><F><C><R><I><G><G><S><R><R><E><R><S><G><Q><H><C><S><D><S><Q><R><T><S><S><A><M><S><G><H><S><R><S><F><I><S><R><E><L><K><E><I><S><S><T><S><Q><T><L><L><P><D><L><S><L><P><D><L><S><E><N><G><L><G><G><R><N><L><L><P><G><V><P><G><M><G><L><A><Q><E><D><T><T><S><L><R><T><L><R><I><S><E><T><S><D><S><S><Q><G><Q><D><S><E><S><V><L><L><V><D><E><A><G><G><S><G><R><A><G><P><A><P><K><G><S><S><L><Q><V><T><F><P><S><E><T><L><N><L><S><E><K><C><I>
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.<BOP>
P35408
Q8NGV0
OR2Y1_HUMAN
Olfactory receptor OR5-2
Homo
<M><G><S><F><N><T><S><F><E><D><G><F><I><L><V><G><F><S><D><W><P><Q><L><E><P><I><L><F><V><F><I><F><I><F><Y><S><L><T><L><F><G><N><T><I><I><I><A><L><S><W><L><D><L><R><L><H><T><P><M><Y><F><F><L><S><H><L><S><L><L><D><L><C><F><T><T><S><T><V><P><Q><L><L><I><N><L><C><G><V><D><R><T><I><T><R><G><G><C><V><A><Q><L><F><I><Y><L><A><L><G><S><T><E><C><V><L><L><V><V><M><A><F><D><R><Y><A><A><V><C><R><P><L><H><Y><M><A><I><M><H><P><H><L><C><Q><T><L><A><I><A><S><W><G><A><G><F><V><N><S><L><I><Q><T><G><L><A><M><A><M><P><L><C><G><H><R><L><N><H><F><F><C><E><M><P><V><F><L><K><L><A><C><A><D><T><E><G><T><E><A><K><M><F><V><A><R><V><I><V><V><A><V><P><A><A><L><I><L><G><S><Y><V><H><I><A><H><A><V><L><R><V><K><S><T><A><G><R><R><K><A><F><G><T><C><G><S><H><L><L><V><V><F><L><F><Y><G><S><A><I><Y><T><Y><L><Q><S><I><H><N><Y><S><E><R><E><G><K><F><V><A><L><F><Y><T><I><I><T><P><I><L><N><P><L><I><Y><T><L><R><N><K><D><V><K><G><A><L><W><K><V><L><W><R><G><R><D><S><G>
Odorant receptor.<BOP>
Q8NGV0
P86791
CCZ1_HUMAN
Vacuolar fusion protein CCZ1 homolog
Homo
<M><A><A><A><A><A><G><A><G><S><G><P><W><A><A><Q><E><K><Q><F><P><P><A><L><L><S><F><F><I><Y><N><P><R><F><G><P><R><E><G><Q><E><E><N><K><I><L><F><Y><H><P><N><E><V><E><K><N><E><K><I><R><N><V><G><L><C><E><A><I><V><Q><F><T><R><T><F><S><P><S><K><P><A><K><S><L><H><T><Q><K><N><R><Q><F><F><N><E><P><E><E><N><F><W><M><V><M><V><V><R><N><P><I><I><E><K><Q><S><K><D><G><K><P><V><I><E><Y><Q><E><E><E><L><L><D><K><V><Y><S><S><V><L><R><Q><C><Y><S><M><Y><K><L><F><N><G><T><F><L><K><A><M><E><D><G><G><V><K><L><L><K><E><R><L><E><K><F><F><H><R><Y><L><Q><T><L><H><L><Q><S><C><D><L><L><D><I><F><G><G><I><S><F><F><P><L><D><K><M><T><Y><L><K><I><Q><S><F><I><N><R><M><E><E><S><L><N><I><V><K><Y><T><A><F><L><Y><N><D><Q><L><I><W><S><G><L><E><Q><D><D><M><R><I><L><Y><K><Y><L><T><T><S><L><F><P><R><H><I><E><P><E><L><A><G><R><D><S><P><I><R><A><E><M><P><G><N><L><Q><H><Y><G><R><F><L><T><G><P><L><N><L><N><D><P><D><A><K><C><R><F><P><K><I><F><V><N><T><D><D><T><Y><E><E><L><H><L><I><V><Y><K><A><M><S><A><A><V><C><F><M><I><D><A><S><V><H><P><T><L><D><F><C><R><R><L><D><S><I><V><G><P><Q><L><T><V><L><A><S><D><I><C><E><Q><F><N><I><N><K><R><M><S><G><S><E><K><E><P><Q><F><K><F><I><Y><F><N><H><M><N><L><A><E><K><S><T><V><H><M><R><K><T><P><S><V><S><L><T><S><V><H><P><D><L><M><K><I><L><G><D><I><N><S><D><F><T><R><V><D><E><D><E><E><I><I><V><K><A><M><S><D><Y><W><V><V><G><K><K><S><D><R><R><E><L><Y><V><I><L><N><Q><K><N><A><N><L><I><E><V><N><E><E><V><K><K><L><C><A><T><Q><F><N><N><I><F><F><L><D>
Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form .<BOP>
P86791
A6NCE7
MP3B2_HUMAN
Microtubule-associated proteins 1A/1B light chain 3B-like
Homo
<M><P><S><E><K><T><F><K><Q><R><R><T><F><E><Q><R><V><E><D><V><R><L><I><R><E><Q><H><P><T><K><I><P><V><I><I><E><R><Y><K><G><E><K><Q><L><P><V><L><D><K><T><K><F><L><V><P><D><H><V><N><M><S><E><L><I><K><I><I><R><R><R><L><Q><L><N><A><N><Q><A><F><F><L><L><V><N><G><H><S><M><V><S><V><S><T><P><I><S><E><V><Y><E><S><E><K><D><E><D><G><F><L><Y><M><V><C><A><S><Q><E><T><F><G><M><K><L><S><V>
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.<BOP>
A6NCE7
P48163
MAOX_HUMAN
Malic enzyme 1
Homo
<M><E><P><E><A><P><R><R><R><H><T><H><Q><R><G><Y><L><L><T><R><N><P><H><L><N><K><D><L><A><F><T><L><E><E><R><Q><Q><L><N><I><H><G><L><L><P><P><S><F><N><S><Q><E><I><Q><V><L><R><V><V><K><N><F><E><H><L><N><S><D><F><D><R><Y><L><L><L><M><D><L><Q><D><R><N><E><K><L><F><Y><R><V><L><T><S><D><I><E><K><F><M><P><I><V><Y><T><P><T><V><G><L><A><C><Q><Q><Y><S><L><V><F><R><K><P><R><G><L><F><I><T><I><H><D><R><G><H><I><A><S><V><L><N><A><W><P><E><D><V><I><K><A><I><V><V><T><D><G><E><R><I><L><G><L><G><D><L><G><C><N><G><M><G><I><P><V><G><K><L><A><L><Y><T><A><C><G><G><M><N><P><Q><E><C><L><P><V><I><L><D><V><G><T><E><N><E><E><L><L><K><D><P><L><Y><I><G><L><R><Q><R><R><V><R><G><S><E><Y><D><D><F><L><D><E><F><M><E><A><V><S><S><K><Y><G><M><N><C><L><I><Q><F><E><D><F><A><N><V><N><A><F><R><L><L><N><K><Y><R><N><Q><Y><C><T><F><N><D><D><I><Q><G><T><A><S><V><A><V><A><G><L><L><A><A><L><R><I><T><K><N><K><L><S><D><Q><T><I><L><F><Q><G><A><G><E><A><A><L><G><I><A><H><L><I><V><M><A><L><E><K><E><G><L><P><K><E><K><A><I><K><K><I><W><L><V><D><S><K><G><L><I><V><K><G><R><A><S><L><T><Q><E><K><E><K><F><A><H><E><H><E><E><M><K><N><L><E><A><I><V><Q><E><I><K><P><T><A><L><I><G><V><A><A><I><G><G><A><F><S><E><Q><I><L><K><D><M><A><A><F><N><E><R><P><I><I><F><A><L><S><N><P><T><S><K><A><E><C><S><A><E><Q><C><Y><K><I><T><K><G><R><A><I><F><A><S><G><S><P><F><D><P><V><T><L><P><N><G><Q><T><L><Y><P><G><Q><G><N><N><S><Y><V><F><P><G><V><A><L><G><V><V><A><C><G><L><R><Q><I><T><D><N><I><F><L><T><T><A><E><V><I><A><Q><Q><V><S><D><K><H><L><E><E><G><R><L><Y><P><P><L><N><T><I><R><D><V><S><L><K><I><A><E><K><I><V><K><D><A><Y><Q><E><K><T><A><T><V><Y><P><E><P><Q><N><K><E><A><F><V><R><S><Q><M><Y><S><T><D><Y><D><Q><I><L><P><D><C><Y><S><W><P><E><E><V><Q><K><I><Q><T><K><V><D><Q>
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate.<BOP>
P48163
Q96AZ6
ISG20_HUMAN
Promyelocytic leukemia nuclear body-associated protein ISG20
Homo
<M><A><G><S><R><E><V><V><A><M><D><C><E><M><V><G><L><G><P><H><R><E><S><G><L><A><R><C><S><L><V><N><V><H><G><A><V><L><Y><D><K><F><I><R><P><E><G><E><I><T><D><Y><R><T><R><V><S><G><V><T><P><Q><H><M><V><G><A><T><P><F><A><V><A><R><L><E><I><L><Q><L><L><K><G><K><L><V><V><G><H><D><L><K><H><D><F><Q><A><L><K><E><D><M><S><G><Y><T><I><Y><D><T><S><T><D><R><L><L><W><R><E><A><K><L><D><H><C><R><R><V><S><L><R><V><L><S><E><R><L><L><H><K><S><I><Q><N><S><L><L><G><H><S><S><V><E><D><A><R><A><T><M><E><L><Y><Q><I><S><Q><R><I><R><A><R><R><G><L><P><R><L><A><V><S><D>
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.<BOP>
Q96AZ6
P0DOX5
IGG1_HUMAN
Immunoglobulin gamma-1 heavy chain NIE
Homo
<Q><V><Q><L><V><Q><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><R><Y><T><I><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><M><S><Y><N><G><N><N><K><H><Y><A><D><S><V><N><G><R><F><T><I><S><R><N><D><S><K><N><T><L><Y><L><N><M><N><S><L><R><P><E><D><T><A><V><Y><Y><C><A><R><I><R><D><T><A><M><F><F><A><H><W><G><Q><G><T><L><V><T><V><S><S><A><S><T><K><G><P><S><V><F><P><L><A><P><S><S><K><S><T><S><G><G><T><A><A><L><G><C><L><V><K><D><Y><F><P><E><P><V><T><V><S><W><N><S><G><A><L><T><S><G><V><H><T><F><P><A><V><L><Q><S><S><G><L><Y><S><L><S><S><V><V><T><V><P><S><S><S><L><G><T><Q><T><Y><I><C><N><V><N><H><K><P><S><N><T><K><V><D><K><K><V><E><P><K><S><C><D><K><T><H><T><C><P><P><C><P><A><P><E><L><L><G><G><P><S><V><F><L><F><P><P><K><P><K><D><T><L><M><I><S><R><T><P><E><V><T><C><V><V><V><D><V><S><H><E><D><P><E><V><K><F><N><W><Y><V><D><G><V><E><V><H><N><A><K><T><K><P><R><E><E><Q><Y><N><S><T><Y><R><V><V><S><V><L><T><V><L><H><Q><D><W><L><N><G><K><E><Y><K><C><K><V><S><N><K><A><L><P><A><P><I><E><K><T><I><S><K><A><K><G><Q><P><R><E><P><Q><V><Y><T><L><P><P><S><R><D><E><L><T><K><N><Q><V><S><L><T><C><L><V><K><G><F><Y><P><S><D><I><A><V><E><W><E><S><N><G><Q><P><E><N><N><Y><K><T><T><P><P><V><L><D><S><D><G><S><F><F><L><Y><S><K><L><T><V><D><K><S><R><W><Q><Q><G><N><V><F><S><C><S><V><M><H><E><A><L><H><N><H><Y><T><Q><K><S><L><S><L><S><P><G><K>
Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DOX5
Q9BQ15
SOSB1_HUMAN
Single-stranded DNA-binding protein 1
Homo
<M><T><T><E><T><F><V><K><D><I><K><P><G><L><K><N><L><N><L><I><F><I><V><L><E><T><G><R><V><T><K><T><K><D><G><H><E><V><R><T><C><K><V><A><D><K><T><G><S><I><N><I><S><V><W><D><D><V><G><N><L><I><Q><P><G><D><I><I><R><L><T><K><G><Y><A><S><V><F><K><G><C><L><T><L><Y><T><G><R><G><G><D><L><Q><K><I><G><E><F><C><M><V><Y><S><E><V><P><N><F><S><E><P><N><P><E><Y><S><T><Q><Q><A><P><N><K><A><V><Q><N><D><S><N><P><S><A><S><Q><P><T><T><G><P><S><A><A><S><P><A><S><E><N><Q><N><G><N><G><L><S><A><P><P><G><P><G><G><G><P><H><P><P><H><T><P><S><H><P><P><S><T><R><I><T><R><S><Q><P><N><H><T><P><A><G><P><P><G><P><S><S><N><P><V><S><N><G><K><E><T><R><R><S><S><K><R>
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<BOP>
Q9BQ15
P02008
HBAZ_HUMAN
Zeta-globin
Homo
<M><S><L><T><K><T><E><R><T><I><I><V><S><M><W><A><K><I><S><T><Q><A><D><T><I><G><T><E><T><L><E><R><L><F><L><S><H><P><Q><T><K><T><Y><F><P><H><F><D><L><H><P><G><S><A><Q><L><R><A><H><G><S><K><V><V><A><A><V><G><D><A><V><K><S><I><D><D><I><G><G><A><L><S><K><L><S><E><L><H><A><Y><I><L><R><V><D><P><V><N><F><K><L><L><S><H><C><L><L><V><T><L><A><A><R><F><P><A><D><F><T><A><E><A><H><A><A><W><D><K><F><L><S><V><V><S><S><V><L><T><E><K><Y><R>
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.<BOP>
P02008
Q8NHY2
COP1_HUMAN
RING-type E3 ubiquitin transferase RFWD2
Homo
<M><S><G><S><R><Q><A><G><S><G><S><A><G><T><S><P><G><S><S><A><A><S><S><V><T><S><A><S><S><S><L><S><S><S><P><S><P><P><S><V><A><V><S><A><A><A><L><V><S><G><G><V><A><Q><A><A><G><S><G><G><L><G><G><P><V><R><P><V><L><V><A><P><A><V><S><G><S><G><G><G><A><V><S><T><G><L><S><R><H><S><C><A><A><R><P><S><A><G><V><G><G><S><S><S><S><L><G><S><G><S><R><K><R><P><L><L><A><P><L><C><N><G><L><I><N><S><Y><E><D><K><S><N><D><F><V><C><P><I><C><F><D><M><I><E><E><A><Y><M><T><K><C><G><H><S><F><C><Y><K><C><I><H><Q><S><L><E><D><N><N><R><C><P><K><C><N><Y><V><V><D><N><I><D><H><L><Y><P><N><F><L><V><N><E><L><I><L><K><Q><K><Q><R><F><E><E><K><R><F><K><L><D><H><S><V><S><S><T><N><G><H><R><W><Q><I><F><Q><D><W><L><G><T><D><Q><D><N><L><D><L><A><N><V><N><L><M><L><E><L><L><V><Q><K><K><K><Q><L><E><A><E><S><H><A><A><Q><L><Q><I><L><M><E><F><L><K><V><A><R><R><N><K><R><E><Q><L><E><Q><I><Q><K><E><L><S><V><L><E><E><D><I><K><R><V><E><E><M><S><G><L><Y><S><P><V><S><E><D><S><T><V><P><Q><F><E><A><P><S><P><S><H><S><S><I><I><D><S><T><E><Y><S><Q><P><P><G><F><S><G><S><S><Q><T><K><K><Q><P><W><Y><N><S><T><L><A><S><R><R><K><R><L><T><A><H><F><E><D><L><E><Q><C><Y><F><S><T><R><M><S><R><I><S><D><D><S><R><T><A><S><Q><L><D><E><F><Q><E><C><L><S><K><F><T><R><Y><N><S><V><R><P><L><A><T><L><S><Y><A><S><D><L><Y><N><G><S><S><I><V><S><S><I><E><F><D><R><D><C><D><Y><F><A><I><A><G><V><T><K><K><I><K><V><Y><E><Y><D><T><V><I><Q><D><A><V><D><I><H><Y><P><E><N><E><M><T><C><N><S><K><I><S><C><I><S><W><S><S><Y><H><K><N><L><L><A><S><S><D><Y><E><G><T><V><I><L><W><D><G><F><T><G><Q><R><S><K><V><Y><Q><E><H><E><K><R><C><W><S><V><D><F><N><L><M><D><P><K><L><L><A><S><G><S><D><D><A><K><V><K><L><W><S><T><N><L><D><N><S><V><A><S><I><E><A><K><A><N><V><C><C><V><K><F><S><P><S><S><R><Y><H><L><A><F><G><C><A><D><H><C><V><H><Y><Y><D><L><R><N><T><K><Q><P><I><M><V><F><K><G><H><R><K><A><V><S><Y><A><K><F><V><S><G><E><E><I><V><S><A><S><T><D><S><Q><L><K><L><W><N><V><G><K><P><Y><C><L><R><S><F><K><G><H><I><N><E><K><N><F><V><G><L><A><S><N><G><D><Y><I><A><C><G><S><E><N><N><S><L><Y><L><Y><Y><K><G><L><S><K><T><L><L><T><F><K><F><D><T><V><K><S><V><L><D><K><D><R><K><E><D><D><T><N><E><F><V><S><A><V><C><W><R><A><L><P><D><G><E><S><N><V><L><I><A><A><N><S><Q><G><T><I><K><V><L><E><L><V>
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a
Q8NHY2
Q13049
TRI32_HUMAN
Zinc finger protein HT2A
Homo
<M><A><A><A><A><A><S><H><L><N><L><D><A><L><R><E><V><L><E><C><P><I><C><M><E><S><F><T><E><E><Q><L><R><P><K><L><L><H><C><G><H><T><I><C><R><Q><C><L><E><K><L><L><A><S><S><I><N><G><V><R><C><P><F><C><S><K><I><T><R><I><T><S><L><T><Q><L><T><D><N><L><T><V><L><K><I><I><D><T><A><G><L><S><E><A><V><G><L><L><M><C><R><S><C><G><R><R><L><P><R><Q><F><C><R><S><C><G><L><V><L><C><E><P><C><R><E><A><D><H><Q><P><P><G><H><C><T><L><P><V><K><E><A><A><E><E><R><R><R><D><F><G><E><K><L><T><R><L><R><E><L><M><G><E><L><Q><R><R><K><A><A><L><E><G><V><S><K><D><L><Q><A><R><Y><K><A><V><L><Q><E><Y><G><H><E><E><R><R><V><Q><D><E><L><A><R><S><R><K><F><F><T><G><S><L><A><E><V><E><K><S><N><S><Q><V><V><E><E><Q><S><Y><L><L><N><I><A><E><V><Q><A><V><S><R><C><D><Y><F><L><A><K><I><K><Q><A><D><V><A><L><L><E><E><T><A><D><E><E><E><P><E><L><T><A><S><L><P><R><E><L><T><L><Q><D><V><E><L><L><K><V><G><H><V><G><P><L><Q><I><G><Q><A><V><K><K><P><R><T><V><N><V><E><D><S><W><A><M><E><A><T><A><S><A><A><S><T><S><V><T><F><R><E><M><D><M><S><P><E><E><V><V><A><S><P><R><A><S><P><A><K><Q><R><G><P><E><A><A><S><N><I><Q><Q><C><L><F><L><K><K><M><G><A><K><G><S><T><P><G><M><F><N><L><P><V><S><L><Y><V><T><S><Q><G><E><V><L><V><A><D><R><G><N><Y><R><I><Q><V><F><T><R><K><G><F><L><K><E><I><R><R><S><P><S><G><I><D><S><F><V><L><S><F><L><G><A><D><L><P><N><L><T><P><L><S><V><A><M><N><C><Q><G><L><I><G><V><T><D><S><Y><D><N><S><L><K><V><Y><T><L><D><G><H><C><V><A><C><H><R><S><Q><L><S><K><P><W><G><I><T><A><L><P><S><G><Q><F><V><V><T><D><V><E><G><G><K><L><W><C><F><T><V><D><R><G><S><G><V><V><K><Y><S><C><L><C><S><A><V><R><P><K><F><V><T><C><D><A><E><G><T><V><Y><F><T><Q><G><L><G><L><N><L><E><N><R><Q><N><E><H><H><L><E><G><G><F><S><I><G><S><V><G><P><D><G><Q><L><G><R><Q><I><S><H><F><F><S><E><N><E><D><F><R><C><I><A><G><M><C><V><D><A><R><G><D><L><I><V><A><D><S><S><R><K><E><I><L><H><F><P><K><G><G><G><Y><S><V><L><I><R><E><G><L><T><C><P><V><G><I><A><L><T><P><K><G><Q><L><L><V><L><D><C><W><D><H><C><I><K><I><Y><S><Y><H><L><R><R><Y><S><T><P>
(Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo .<BOP>
Q13049
P01160
ANF_HUMAN
Atriopeptin III
Homo
<M><S><S><F><S><T><T><T><V><S><F><L><L><L><L><A><F><Q><L><L><G><Q><T><R><A><N><P><M><Y><N><A><V><S><N><A><D><L><M><D><F><K><N><L><L><D><H><L><E><E><K><M><P><L><E><D><E><V><V><P><P><Q><V><L><S><E><P><N><E><E><A><G><A><A><L><S><P><L><P><E><V><P><P><W><T><G><E><V><S><P><A><Q><R><D><G><G><A><L><G><R><G><P><W><D><S><S><D><R><S><A><L><L><K><S><K><L><R><A><L><L><T><A><P><R><S><L><R><R><S><S><C><F><G><G><R><M><D><R><I><G><A><Q><S><G><L><G><C><N><S><F><R><Y>
May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.<BOP>
P01160
P13987
CD59_HUMAN
Protectin
Homo
<M><G><I><Q><G><G><S><V><L><F><G><L><L><L><V><L><A><V><F><C><H><S><G><H><S><L><Q><C><Y><N><C><P><N><P><T><A><D><C><K><T><A><V><N><C><S><S><D><F><D><A><C><L><I><T><K><A><G><L><Q><V><Y><N><K><C><W><K><F><E><H><C><N><F><N><D><V><T><T><R><L><R><E><N><E><L><T><Y><Y><C><C><K><K><D><L><C><N><F><N><E><Q><L><E><N><G><G><T><S><L><S><E><K><T><V><L><L><L><V><T><P><F><L><A><A><A><W><S><L><H><P>
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.<BOP>
P13987
Q86UQ8
NFE4_HUMAN
Transcription factor NF-E4
Homo
<M><P><R><V><V><C><W><H><T><L><K><S><L><N><G><Y><K><N><L><S><S><G><A><E><T><R><E><G><L><R><S><S><S><P><V><D><L><P><L><R><P><R><K><Q><A><T><A><A><G><Q><R><K><L><L><S><L><Q><L><L><L><C><A><C><T><S><V><T><D><L><T><Y><W><G><P><A><G><H><G><A><T><A><P><H><R><S><L><L><A><I><H><L><H><L><V><P><A><S><S><A><A><M><K><A><T><G><P><H><N><A><Q><T><Q><V><N><P><Q><G><H><A><P><S><A><E><D><P><T><G><T><W><T><V><S><G><P><C><K><D><H><P><H><P><F><L><S><Q><S><N><P><P><T><R><I><S><S><A><L><P><L><K><T><D><S><A><L><E><Q><T><P><Q><Q><L><P><S><L><H><L><S><Q><G>
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.<BOP>
Q86UQ8
A1Z1Q3
MACD2_HUMAN
[Protein ADP-ribosylglutamate] hydrolase MACROD2
Homo
<M><Y><P><S><N><K><K><K><K><V><W><R><E><E><K><E><R><L><L><K><M><T><L><E><E><R><R><K><E><Y><L><R><D><Y><I><P><L><N><S><I><L><S><W><K><E><E><M><K><G><K><G><Q><N><D><E><E><N><T><Q><E><T><S><Q><V><K><K><S><L><T><E><K><V><S><L><Y><R><G><D><I><T><L><L><E><V><D><A><I><V><N><A><A><N><A><S><L><L><G><G><G><G><V><D><G><C><I><H><R><A><A><G><P><C><L><L><A><E><C><R><N><L><N><G><C><D><T><G><H><A><K><I><T><C><G><Y><D><L><P><A><K><Y><V><I><H><T><V><G><P><I><A><R><G><H><I><N><G><S><H><K><E><D><L><A><N><C><Y><K><S><S><L><K><L><V><K><E><N><N><I><R><S><V><A><F><P><C><I><S><T><G><I><Y><G><F><P><N><E><P><A><A><V><I><A><L><N><T><I><K><E><W><L><A><K><N><H><H><E><V><D><R><I><I><F><C><V><F><L><E><V><D><F><K><I><Y><K><K><K><M><N><E><F><F><S><V><D><D><N><N><E><E><E><E><D><V><E><M><K><E><D><S><D><E><N><G><P><E><E><K><Q><S><V><E><E><M><E><E><Q><S><Q><D><A><D><G><V><N><T><V><T><V><P><G><P><A><S><E><E><A><V><E><D><C><K><D><E><D><F><A><K><D><E><N><I><T><K><G><G><E><V><T><D><H><S><V><R><D><Q><D><H><P><D><G><Q><E><N><D><S><T><K><N><E><I><K><I><E><T><E><S><Q><S><S><Y><M><E><T><E><E><L><S><S><N><Q><E><D><A><V><I><V><E><Q><P><E><V><I><P><L><T><E><D><Q><E><E><K><E><G><E><K><A><P><G><E><D><T><P><R><M><P><G><K><S><E><G><S><S><D><L><E><N><T><P><G><P><D><A><G><A><Q><D><E><A><K><E><Q><R><N><G><T><K>
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety . Inactive towards proteins bearing poly-ADP-ribose . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins .<BOP>
A1Z1Q3
Q6NXP2
GAR1A_HUMAN
Golgi-associated RAB2 interactor protein 1A
Homo
<M><S><K><I><R><G><L><P><P><E><V><R><E><P><G><P><G><V><E><L><G><V><E><N><G><L><L><C><Q><L><I><H><S><P><E><F><N><L><F><S><N><S><V><V><F><E><S><N><F><I><Q><T><H><V><P><E><A><D><F><Q><V><T><K><P><G><N><W><R><D><V><C><E><G><S><A><T><V><I><L><G><V><T><S><S><V><P><S><L><P><L><P><N><V><L><L><M><A><N><V><T><W><P><Q><G><P><F><T><T><W><S><T><P><G><D><A><P><V><I><N><L><S><R><L><L><P><L><K><Y><V><E><L><R><I><Y><D><R><L><Q><R><I><L><R><V><R><T><V><T><E><K><I><Y><Y><L><K><L><H><E><K><H><P><E><I><V><F><Q><F><W><V><R><L><V><K><I><L><Q><K><G><L><S><I><T><T><K><D><P><R><I><K><F><T><H><C><L><V><P><K><M><P><T><N><S><T><E><T><T><P><E><N><S><L><L><S><S><P><Q><P><S><E><P><L><V><L><L><A><A><E><Q><T><S><G><S><F><S><Q><L><S><G><K><P><Q><L><T><A><D><R><N><N><D><T><A><I><E><I><D><N><C><S><S><Y><K><I><P><S><P><V><A><S><P><I><N><L><N><I><P><M><R><A><A><L><S><H><S><L><W><E><Q><E><D><W><N><E><H><L><L><Q><V><H><I><A><S><Y><L><G><E><H><F><L><G><A>
RAB2B effector protein required for accurate acrosome formation and normal male fertility.<BOP>
Q6NXP2
P07098
LIPG_HUMAN
Gastric triacylglycerol lipase
Homo
<M><W><L><L><L><T><M><A><S><L><I><S><V><L><G><T><T><H><G><L><F><G><K><L><H><P><G><S><P><E><V><T><M><N><I><S><Q><M><I><T><Y><W><G><Y><P><N><E><E><Y><E><V><V><T><E><D><G><Y><I><L><E><V><N><R><I><P><Y><G><K><K><N><S><G><N><T><G><Q><R><P><V><V><F><L><Q><H><G><L><L><A><S><A><T><N><W><I><S><N><L><P><N><N><S><L><A><F><I><L><A><D><A><G><Y><D><V><W><L><G><N><S><R><G><N><T><W><A><R><R><N><L><Y><Y><S><P><D><S><V><E><F><W><A><F><S><F><D><E><M><A><K><Y><D><L><P><A><T><I><D><F><I><V><K><K><T><G><Q><K><Q><L><H><Y><V><G><H><S><Q><G><T><T><I><G><F><I><A><F><S><T><N><P><S><L><A><K><R><I><K><T><F><Y><A><L><A><P><V><A><T><V><K><Y><T><K><S><L><I><N><K><L><R><F><V><P><Q><S><L><F><K><F><I><F><G><D><K><I><F><Y><P><H><N><F><F><D><Q><F><L><A><T><E><V><C><S><R><E><M><L><N><L><L><C><S><N><A><L><F><I><I><C><G><F><D><S><K><N><F><N><T><S><R><L><D><V><Y><L><S><H><N><P><A><G><T><S><V><Q><N><M><F><H><W><T><Q><A><V><K><S><G><K><F><Q><A><Y><D><W><G><S><P><V><Q><N><R><M><H><Y><D><Q><S><Q><P><P><Y><Y><N><V><T><A><M><N><V><P><I><A><V><W><N><G><G><K><D><L><L><A><D><P><Q><D><V><G><L><L><L><P><K><L><P><N><L><I><Y><H><K><E><I><P><F><Y><N><H><L><D><F><I><W><A><M><D><A><P><Q><E><V><Y><N><D><I><V><S><M><I><S><E><D><K><K>
Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol . Shows a preferential hydrolysis at the sn-3 position of triacylglycerol .<BOP>
P07098
Q9P242
NYAP2_HUMAN
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Homo
<M><I><S><S><K><M><M><S><S><N><P><E><E><D><P><L><D><T><F><L><Q><Y><I><E><D><M><G><M><K><A><Y><D><G><L><V><I><Q><N><A><S><D><I><A><R><E><N><D><R><L><R><N><E><T><N><L><A><Y><L><K><E><K><N><E><K><R><R><R><Q><E><E><A><I><K><R><I><G><G><E><V><G><R><G><H><E><G><S><Y><V><G><K><H><F><R><M><G><F><M><T><M><P><A><P><Q><D><R><L><P><H><P><C><S><S><G><F><S><V><R><S><Q><S><L><H><S><V><G><G><T><D><D><D><S><S><C><G><S><R><R><Q><P><P><P><K><P><K><R><D><P><S><T><K><L><S><T><S><S><E><T><V><S><S><T><A><A><S><K><S><G><K><T><P><E><R><T><E><A><S><A><K><P><R><P><H><S><D><E><Y><S><K><K><I><P><P><P><K><P><K><R><N><P><N><T><Q><L><S><T><S><F><D><E><T><Y><I><K><K><H><G><P><R><R><T><S><L><P><R><D><S><S><L><S><Q><M><G><S><P><A><G><D><P><E><E><E><E><P><V><Y><I><E><M><V><G><N><I><L><R><D><F><R><K><E><D><D><D><Q><S><E><A><V><Y><E><E><M><K><Y><P><I><F><D><D><L><G><Q><D><A><K><C><D><F><D><H><H><S><C><S><S><Q><C><A><T><P><T><V><P><D><L><D><F><A><K><A><S><V><P><C><P><P><K><G><L><L><C><D><I><P><P><P><F><P><N><L><L><S><H><R><P><P><L><L><V><F><P><P><A><P><V><H><C><S><P><N><S><D><E><S><P><L><T><P><L><E><V><T><K><L><P><V><L><E><N><V><S><Y><M><K><Q><P><A><G><A><S><P><S><T><L><P><S><H><V><P><G><H><A><K><L><E><K><E><Q><A><A><A><L><G><P><A><S><A><T><P><A><L><S><S><S><P><P><P><P><S><T><L><Y><R><T><Q><S><P><H><G><Y><P><K><S><H><S><T><S><P><S><P><V><S><M><G><R><S><L><T><P><L><S><L><K><R><P><P><P><Y><D><A><V><H><S><G><S><L><S><R><S><S><P><S><V><P><H><S><T><P><R><P><V><S><Q><D><G><A><K><M><V><N><A><A><V><N><T><Y><G><A><A><P><G><G><S><R><S><R><T><P><T><S><P><L><E><E><L><T><S><L><F><S><S><G><R><S><L><L><R><K><S><S><S><G><R><R><S><K><E><P><A><E><K><S><T><E><E><L><K><V><R><S><H><S><T><E><P><L><P><K><L><D><N><K><E><R><G><H><H><G><A><S><S><S><R><E><P><V><K><A><Q><E><W><D><G><T><P><G><T><P><V><V><T><S><R><L><G><R><C><S><V><S><P><T><L><L><A><G><N><H><S><S><E><P><K><V><S><C><K><L><G><R><S><A><S><T><S><G><V><P><P><P><S><V><T><P><L><R><Q><S><S><D><L><Q><Q><S><Q><V><P><S><S><L><A><N><R><D>
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.<BOP>
Q9P242
O95073
FSBP_HUMAN
Fibrinogen silencer-binding protein
Homo
<M><V><G><K><A><R><S><S><N><F><T><L><S><E><K><L><D><L><L><K><L><V><K><P><Y><V><K><I><L><E><E><H><T><N><K><H><S><V><I><V><E><K><N><R><C><W><D><I><I><A><V><N><Y><N><A><I><G><V><D><R><P><P><R><T><A><Q><G><L><R><T><L><Y><K><R><L><K><E><Y><A><K><Q><E><L><L><Q><Q><K><E><T><Q><S><D><F><K><S><N><I><S><E><P><T><K><K><V><M><E><M><I><P><Q><I><S><S><F><C><L><V><R><D><R><N><H><I><Q><S><A><N><L><D><E><E><A><Q><A><G><T><S><S><L><Q><V><M><L><D><H><H><P><V><A><I><T><V><E><V><K><Q><E><E><D><I><K><P><P><P><P><L><V><L><N><S><Q><Q><S><D><T><L><E><Q><R><E><E><H><E><L><V><H><V><M><E><R><S><L><S><P><S><L><S><S><V><D><M><R><M><T><S><S><P><S><S><I><P><R><R><D><D><F><F><R><H><E><S><G><E><H><F><R><S><L><L><G><Y><D><P><Q><I><L><Q><M><L><K><E><E><H><Q><I><I><L><E><N><Q><K><N><F><G><L><Y><V><Q><E><K><R><D><G><L><K><R><R><Q><Q><L><E><E><E><L><L><R><A><K><I><E><V><E><K><L><K><A><I><R><L><R><H><D><L><P><E><Y><N><S><L>
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.<BOP>
O95073
Q8IV42
PSTK_HUMAN
O-phosphoseryl-tRNA(Sec) kinase
Homo
<M><K><T><A><E><N><I><R><G><T><G><S><D><G><P><R><K><R><G><L><C><V><L><C><G><L><P><A><A><G><K><S><T><F><A><R><A><L><A><H><R><L><Q><Q><E><Q><G><W><A><I><G><V><V><A><Y><D><D><V><M><P><D><A><F><L><A><G><A><R><A><R><P><A><P><S><Q><W><K><L><L><R><Q><E><L><L><K><Y><L><E><Y><F><L><M><A><V><I><N><G><C><Q><M><S><V><P><P><N><R><T><E><A><M><W><E><D><F><I><T><C><L><K><D><Q><D><L><I><F><S><A><A><F><E><A><Q><S><C><Y><L><L><T><K><T><A><V><S><R><P><L><F><L><V><L><D><D><N><F><Y><Y><Q><S><M><R><Y><E><V><Y><Q><L><A><R><K><Y><S><L><G><F><C><Q><L><F><L><D><C><P><L><E><T><C><L><Q><R><N><G><Q><R><P><Q><A><L><P><P><E><T><I><H><L><M><G><R><K><L><E><K><P><N><P><E><K><N><A><W><E><H><N><S><L><T><I><P><S><P><A><C><A><S><E><A><S><L><E><V><T><D><L><L><L><T><A><L><E><N><P><V><K><Y><A><E><D><N><M><E><Q><K><D><T><D><R><I><I><C><S><T><N><I><L><H><K><T><D><Q><T><L><R><R><I><V><S><Q><T><M><K><E><A><K><G><N><Q><E><A><F><S><E><M><T><F><K><Q><R><W><V><R><A><N><H><A><A><I><W><R><I><I><L><G><N><E><H><I><K><C><R><S><A><K><V><G><W><L><Q><C><C><R><I><E><K><R><P><L><S><T><G>
Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.<BOP>
Q8IV42
P05160
F13B_HUMAN
Transglutaminase B chain
Homo
<M><R><L><K><N><L><T><F><I><I><I><L><I><I><S><G><E><L><Y><A><E><E><K><P><C><G><F><P><H><V><E><N><G><R><I><A><Q><Y><Y><Y><T><F><K><S><F><Y><F><P><M><S><I><D><K><K><L><S><F><F><C><L><A><G><Y><T><T><E><S><G><R><Q><E><E><Q><T><T><C><T><T><E><G><W><S><P><E><P><R><C><F><K><K><C><T><K><P><D><L><S><N><G><Y><I><S><D><V><K><L><L><Y><K><I><Q><E><N><M><R><Y><G><C><A><S><G><Y><K><T><T><G><G><K><D><E><E><V><V><Q><C><L><S><D><G><W><S><S><Q><P><T><C><R><K><E><H><E><T><C><L><A><P><E><L><Y><N><G><N><Y><S><T><T><Q><K><T><F><K><V><K><D><K><V><Q><Y><E><C><A><T><G><Y><Y><T><A><G><G><K><K><T><E><E><V><E><C><L><T><Y><G><W><S><L><T><P><K><C><T><K><L><K><C><S><S><L><R><L><I><E><N><G><Y><F><H><P><V><K><Q><T><Y><E><E><G><D><V><V><Q><F><F><C><H><E><N><Y><Y><L><S><G><S><D><L><I><Q><C><Y><N><F><G><W><Y><P><E><S><P><V><C><E><G><R><R><N><R><C><P><P><P><P><L><P><I><N><S><K><I><Q><T><H><S><T><T><Y><R><H><G><E><I><V><H><I><E><C><E><L><N><F><E><I><H><G><S><A><E><I><R><C><E><D><G><K><W><T><E><P><P><K><C><I><E><G><Q><E><K><V><A><C><E><E><P><P><F><I><E><N><G><A><A><N><L><H><S><K><I><Y><Y><N><G><D><K><V><T><Y><A><C><K><S><G><Y><L><L><H><G><S><N><E><I><T><C><N><R><G><K><W><T><L><P><P><E><C><V><E><N><N><E><N><C><K><H><P><P><V><V><M><N><G><A><V><A><D><G><I><L><A><S><Y><A><T><G><S><S><V><E><Y><R><C><N><E><Y><Y><L><L><R><G><S><K><I><S><R><C><E><Q><G><K><W><S><S><P><P><V><C><L><E><P><C><T><V><N><V><D><Y><M><N><R><N><N><I><E><M><K><W><K><Y><E><G><K><V><L><H><G><D><L><I><D><F><V><C><K><Q><G><Y><D><L><S><P><L><T><P><L><S><E><L><S><V><Q><C><N><R><G><E><V><K><Y><P><L><C><T><R><K><E><S><K><G><M><C><T><S><P><P><L><I><K><H><G><V><I><I><S><S><T><V><D><T><Y><E><N><G><S><S><V><E><Y><R><C><F><D><H><H><F><L><E><G><S><R><E><A><Y><C><L><D><G><M><W><T><T><P><P><L><C><L><E><P><C><T><L><S><F><T><E><M><E><K><N><N><L><L><L><K><W><D><F><D><N><R><P><H><I><L><H><G><E><Y><I><E><F><I><C><R><G><D><T><Y><P><A><E><L><Y><I><T><G><S><I><L><R><M><Q><C><D><R><G><Q><L><K><Y><P><R><C><I><P><R><Q><S><T><L><S><Y><Q><E><P><L><R><T>
The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.<BOP>
P05160
P20810
ICAL_HUMAN
Sperm BS-17 component
Homo
<M><N><P><T><E><T><K><A><I><P><V><S><Q><Q><M><E><G><P><H><L><P><N><K><K><K><H><K><K><Q><A><V><K><T><E><P><E><K><K><S><Q><S><T><K><L><S><V><V><H><E><K><K><S><Q><E><G><K><P><K><E><H><T><E><P><K><S><L><P><K><Q><A><S><D><T><G><S><N><D><A><H><N><K><K><A><V><S><R><S><A><E><Q><Q><P><S><E><K><S><T><E><P><K><T><K><P><Q><D><M><I><S><A><G><G><E><S><V><A><G><I><T><A><I><S><G><K><P><G><D><K><K><K><E><K><K><S><L><T><P><A><V><P><V><E><S><K><P><D><K><P><S><G><K><S><G><M><D><A><A><L><D><D><L><I><D><T><L><G><G><P><E><E><T><E><E><E><N><T><T><Y><T><G><P><E><V><S><D><P><M><S><S><T><Y><I><E><E><L><G><K><R><E><V><T><I><P><P><K><Y><R><E><L><L><A><K><K><E><G><I><T><G><P><P><A><D><S><S><K><P><I><G><P><D><D><A><I><D><A><L><S><S><D><F><T><C><G><S><P><T><A><A><G><K><K><T><E><K><E><E><S><T><E><V><L><K><A><Q><S><A><G><T><V><R><S><A><A><P><P><Q><E><K><K><R><K><V><E><K><D><T><M><S><D><Q><A><L><E><A><L><S><A><S><L><G><T><R><Q><A><E><P><E><L><D><L><R><S><I><K><E><V><D><E><A><K><A><K><E><E><K><L><E><K><C><G><E><D><D><E><T><I><P><S><E><Y><R><L><K><P><A><T><D><K><D><G><K><P><L><L><P><E><P><E><E><K><P><K><P><R><S><E><S><E><L><I><D><E><L><S><E><D><F><D><R><S><E><C><K><E><K><P><S><K><P><T><E><K><T><E><E><S><K><A><A><A><P><A><P><V><S><E><A><V><C><R><T><S><M><C><S><I><Q><S><A><P><P><E><P><A><T><L><K><G><T><V><P><D><D><A><V><E><A><L><A><D><S><L><G><K><K><E><A><D><P><E><D><G><K><P><V><M><D><K><V><K><E><K><A><K><E><E><D><R><E><K><L><G><E><K><E><E><T><I><P><P><D><Y><R><L><E><E><V><K><D><K><D><G><K><P><L><L><P><K><E><S><K><E><Q><L><P><P><M><S><E><D><F><L><L><D><A><L><S><E><D><F><S><G><P><Q><N><A><S><S><L><K><F><E><D><A><K><L><A><A><A><I><S><E><V><V><S><Q><T><P><A><S><T><T><Q><A><G><A><P><P><R><D><T><S><Q><S><D><K><D><L><D><D><A><L><D><K><L><S><D><S><L><G><Q><R><Q><P><D><P><D><E><N><K><P><M><E><D><K><V><K><E><K><A><K><A><E><H><R><D><K><L><G><E><R><D><D><T><I><P><P><E><Y><R><H><L><L><D><D><N><G><Q><D><K><P><V><K><P><P><T><K><K><S><E><D><S><K><K><P><A><D><D><Q><D><P><I><D><A><L><S><G><D><L><D><S><C><P><S><T><T><E><T><S><Q><N><T><A><K><D><K><C><K><K><A><A><S><S><S><K><A><P><K><N><G><G><K><A><K><D><S><A><K><T><T><E><E><T><S><K><P><K><D><D>
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.<BOP>
P20810
P36896
ACV1B_HUMAN
Serine/threonine-protein kinase receptor R2
Homo
<M><A><E><S><A><G><A><S><S><F><F><P><L><V><V><L><L><L><A><G><S><G><G><S><G><P><R><G><V><Q><A><L><L><C><A><C><T><S><C><L><Q><A><N><Y><T><C><E><T><D><G><A><C><M><V><S><I><F><N><L><D><G><M><E><H><H><V><R><T><C><I><P><K><V><E><L><V><P><A><G><K><P><F><Y><C><L><S><S><E><D><L><R><N><T><H><C><C><Y><T><D><Y><C><N><R><I><D><L><R><V><P><S><G><H><L><K><E><P><E><H><P><S><M><W><G><P><V><E><L><V><G><I><I><A><G><P><V><F><L><L><F><L><I><I><I><I><V><F><L><V><I><N><Y><H><Q><R><V><Y><H><N><R><Q><R><L><D><M><E><D><P><S><C><E><M><C><L><S><K><D><K><T><L><Q><D><L><V><Y><D><L><S><T><S><G><S><G><S><G><L><P><L><F><V><Q><R><T><V><A><R><T><I><V><L><Q><E><I><I><G><K><G><R><F><G><E><V><W><R><G><R><W><R><G><G><D><V><A><V><K><I><F><S><S><R><E><E><R><S><W><F><R><E><A><E><I><Y><Q><T><V><M><L><R><H><E><N><I><L><G><F><I><A><A><D><N><K><D><N><G><T><W><T><Q><L><W><L><V><S><D><Y><H><E><H><G><S><L><F><D><Y><L><N><R><Y><T><V><T><I><E><G><M><I><K><L><A><L><S><A><A><S><G><L><A><H><L><H><M><E><I><V><G><T><Q><G><K><P><G><I><A><H><R><D><L><K><S><K><N><I><L><V><K><K><N><G><M><C><A><I><A><D><L><G><L><A><V><R><H><D><A><V><T><D><T><I><D><I><A><P><N><Q><R><V><G><T><K><R><Y><M><A><P><E><V><L><D><E><T><I><N><M><K><H><F><D><S><F><K><C><A><D><I><Y><A><L><G><L><V><Y><W><E><I><A><R><R><C><N><S><G><G><V><H><E><E><Y><Q><L><P><Y><Y><D><L><V><P><S><D><P><S><I><E><E><M><R><K><V><V><C><D><Q><K><L><R><P><N><I><P><N><W><W><Q><S><Y><E><A><L><R><V><M><G><K><M><M><R><E><C><W><Y><A><N><G><A><A><R><L><T><A><L><R><I><K><K><T><L><S><Q><L><S><V><Q><E><D><V><K><I>
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail
P36896
P04196
HRG_HUMAN
Histidine-proline-rich glycoprotein
Homo
<M><K><A><L><I><A><A><L><L><L><I><T><L><Q><Y><S><C><A><V><S><P><T><D><C><S><A><V><E><P><E><A><E><K><A><L><D><L><I><N><K><R><R><R><D><G><Y><L><F><Q><L><L><R><I><A><D><A><H><L><D><R><V><E><N><T><T><V><Y><Y><L><V><L><D><V><Q><E><S><D><C><S><V><L><S><R><K><Y><W><N><D><C><E><P><P><D><S><R><R><P><S><E><I><V><I><G><Q><C><K><V><I><A><T><R><H><S><H><E><S><Q><D><L><R><V><I><D><F><N><C><T><T><S><S><V><S><S><A><L><A><N><T><K><D><S><P><V><L><I><D><F><F><E><D><T><E><R><Y><R><K><Q><A><N><K><A><L><E><K><Y><K><E><E><N><D><D><F><A><S><F><R><V><D><R><I><E><R><V><A><R><V><R><G><G><E><G><T><G><Y><F><V><D><F><S><V><R><N><C><P><R><H><H><F><P><R><H><P><N><V><F><G><F><C><R><A><D><L><F><Y><D><V><E><A><L><D><L><E><S><P><K><N><L><V><I><N><C><E><V><F><D><P><Q><E><H><E><N><I><N><G><V><P><P><H><L><G><H><P><F><H><W><G><G><H><E><R><S><S><T><T><K><P><P><F><K><P><H><G><S><R><D><H><H><H><P><H><K><P><H><E><H><G><P><P><P><P><P><D><E><R><D><H><S><H><G><P><P><L><P><Q><G><P><P><P><L><L><P><M><S><C><S><S><C><Q><H><A><T><F><G><T><N><G><A><Q><R><H><S><H><N><N><N><S><S><D><L><H><P><H><K><H><H><S><H><E><Q><H><P><H><G><H><H><P><H><A><H><H><P><H><E><H><D><T><H><R><Q><H><P><H><G><H><H><P><H><G><H><H><P><H><G><H><H><P><H><G><H><H><P><H><G><H><H><P><H><C><H><D><F><Q><D><Y><G><P><C><D><P><P><P><H><N><Q><G><H><C><C><H><G><H><G><P><P><P><G><H><L><R><R><R><G><P><G><K><G><P><R><P><F><H><C><R><Q><I><G><S><V><Y><R><L><P><P><L><R><K><G><E><V><L><P><L><P><E><A><N><F><P><S><F><P><L><P><H><H><K><H><P><L><K><P><D><N><Q><P><F><P><Q><S><V><S><E><S><C><P><G><K><F><K><S><G><F><P><Q><V><S><M><F><F><T><H><T><F><P><K>
Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface
P04196
Q9H9A7
RMI1_HUMAN
FAAP75
Homo
<M><N><V><T><S><I><A><L><R><A><E><T><W><L><L><A><A><W><H><V><K><V><P><P><M><W><L><E><A><C><I><N><W><I><Q><E><E><N><N><N><V><N><L><S><Q><A><Q><M><N><K><Q><V><F><E><Q><W><L><L><T><D><L><R><D><L><E><H><P><L><L><P><D><G><I><L><E><I><P><K><G><E><L><N><G><F><Y><A><L><Q><I><N><S><L><V><D><V><S><Q><P><A><Y><S><Q><I><Q><K><L><R><G><K><N><T><T><N><D><L><V><T><A><E><A><Q><V><T><P><K><P><W><E><A><K><P><S><R><M><L><M><L><Q><L><T><D><G><I><V><Q><I><Q><G><M><E><Y><Q><P><I><P><I><L><H><S><D><L><P><P><G><T><K><I><L><I><Y><G><N><I><S><F><R><L><G><V><L><L><L><K><P><E><N><V><K><V><L><G><G><E><V><D><A><L><L><E><E><Y><A><Q><E><K><V><L><A><R><L><I><G><E><P><D><L><V><V><S><V><I><P><N><N><S><N><E><N><I><P><R><V><T><D><V><L><D><P><A><L><G><P><S><D><E><E><L><L><A><S><L><D><E><N><D><E><L><T><A><N><N><D><T><S><S><E><R><C><F><T><T><G><S><S><S><N><T><I><P><T><R><Q><S><S><F><E><P><E><F><V><I><S><P><R><P><K><E><E><P><S><N><L><S><I><H><V><M><D><G><E><L><D><D><F><S><L><E><E><A><L><L><L><E><E><T><V><Q><K><E><Q><M><E><T><K><E><L><Q><P><L><T><F><N><R><N><A><D><R><S><I><E><R><F><S><H><N><P><N><T><T><N><N><F><S><L><T><C><K><N><G><N><N><N><W><S><E><K><N><V><S><E><Q><M><T><N><E><D><K><S><F><G><C><P><S><V><R><D><Q><N><R><S><I><F><S><V><H><C><N><V><P><L><A><H><D><F><T><N><K><E><K><N><L><E><T><D><N><K><I><K><Q><T><S><S><S><D><S><H><S><L><N><N><K><I><L><N><R><E><V><V><N><Y><V><Q><K><R><N><S><Q><I><S><N><E><N><D><C><N><L><Q><S><C><S><L><R><S><S><E><N><S><I><N><L><S><I><A><M><D><L><Y><S><P><P><F><V><Y><L><S><V><L><M><A><S><K><P><K><E><V><T><T><V><K><V><K><A><F><I><V><T><L><T><G><N><L><S><S><S><G><G><I><W><S><I><T><A><K><V><S><D><G><T><A><Y><L><D><V><D><F><V><D><E><I><L><T><S><L><I><G><F><S><V><P><E><M><K><Q><S><K><K><D><P><L><Q><Y><Q><K><F><L><E><G><L><Q><K><C><Q><R><D><L><I><D><L><C><C><L><M><T><I><S><F><N><P><S><L><S><K><A><M><V><L><A><L><Q><D><V><N><M><E><H><L><E><N><L><K><K><R><L><N><K>
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.<BOP>
Q9H9A7
Q9BWW7
SCRT1_HUMAN
Scratch homolog 1 zinc finger protein
Homo
<M><P><R><S><F><L><V><K><K><V><K><L><D><A><F><S><S><A><D><L><E><S><A><Y><G><R><A><R><S><D><L><G><A><P><L><H><D><K><G><Y><L><S><D><Y><V><G><P><S><S><V><Y><D><G><D><A><E><A><A><L><L><K><G><P><S><P><E><P><M><Y><A><A><A><V><R><G><E><L><G><P><A><A><A><G><S><A><P><P><P><T><P><R><P><E><L><A><T><A><A><G><G><Y><I><N><G><D><A><A><V><S><E><G><Y><A><A><D><A><F><F><I><T><D><G><R><S><R><R><K><A><S><N><A><G><A><A><A><A><P><S><T><A><S><A><A><A><P><D><G><D><A><G><G><G><G><G><A><G><G><R><S><L><G><S><G><P><G><G><R><G><G><T><R><A><G><A><G><T><E><A><R><A><G><P><G><A><A><G><A><G><G><R><H><A><C><G><E><C><G><K><T><Y><A><T><S><S><N><L><S><R><H><K><Q><T><H><R><S><L><D><S><Q><L><A><R><R><C><P><T><C><G><K><V><Y><V><S><M><P><A><M><A><M><H><L><L><T><H><D><L><R><H><K><C><G><V><C><G><K><A><F><S><R><P><W><L><L><Q><G><H><M><R><S><H><T><G><E><K><P><F><G><C><A><H><C><G><K><A><F><A><D><R><S><N><L><R><A><H><M><Q><T><H><S><A><F><K><H><F><Q><C><K><R><C><K><K><S><F><A><L><K><S><Y><L><N><K><H><Y><E><S><A><C><F><K><G><G><A><G><G><P><A><A><P><A><P><P><Q><L><S><P><V><Q><A>
Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.<BOP>
Q9BWW7
P04180
LCAT_HUMAN
Platelet-activating factor acetylhydrolase
Homo
<M><G><P><P><G><S><P><W><Q><W><V><T><L><L><L><G><L><L><L><P><P><A><A><P><F><W><L><L><N><V><L><F><P><P><H><T><T><P><K><A><E><L><S><N><H><T><R><P><V><I><L><V><P><G><C><L><G><N><Q><L><E><A><K><L><D><K><P><D><V><V><N><W><M><C><Y><R><K><T><E><D><F><F><T><I><W><L><D><L><N><M><F><L><P><L><G><V><D><C><W><I><D><N><T><R><V><V><Y><N><R><S><S><G><L><V><S><N><A><P><G><V><Q><I><R><V><P><G><F><G><K><T><Y><S><V><E><Y><L><D><S><S><K><L><A><G><Y><L><H><T><L><V><Q><N><L><V><N><N><G><Y><V><R><D><E><T><V><R><A><A><P><Y><D><W><R><L><E><P><G><Q><Q><E><E><Y><Y><R><K><L><A><G><L><V><E><E><M><H><A><A><Y><G><K><P><V><F><L><I><G><H><S><L><G><C><L><H><L><L><Y><F><L><L><R><Q><P><Q><A><W><K><D><R><F><I><D><G><F><I><S><L><G><A><P><W><G><G><S><I><K><P><M><L><V><L><A><S><G><D><N><Q><G><I><P><I><M><S><S><I><K><L><K><E><E><Q><R><I><T><T><T><S><P><W><M><F><P><S><R><M><A><W><P><E><D><H><V><F><I><S><T><P><S><F><N><Y><T><G><R><D><F><Q><R><F><F><A><D><L><H><F><E><E><G><W><Y><M><W><L><Q><S><R><D><L><L><A><G><L><P><A><P><G><V><E><V><Y><C><L><Y><G><V><G><L><P><T><P><R><T><Y><I><Y><D><H><G><F><P><Y><T><D><P><V><G><V><L><Y><E><D><G><D><D><T><V><A><T><R><S><T><E><L><C><G><L><W><Q><G><R><Q><P><Q><P><V><H><L><L><P><L><H><G><I><Q><H><L><N><M><V><F><S><N><L><T><L><E><H><I><N><A><I><L><L><G><A><Y><R><Q><G><P><P><A><S><P><T><A><S><P><E><P><P><P><P><E>
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) . The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines . Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms . Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (plate
P04180
Q16570
ACKR1_HUMAN
Plasmodium vivax receptor
Homo
<M><G><N><C><L><H><R><A><E><L><S><P><S><T><E><N><S><S><Q><L><D><F><E><D><V><W><N><S><S><Y><G><V><N><D><S><F><P><D><G><D><Y><G><A><N><L><E><A><A><A><P><C><H><S><C><N><L><L><D><D><S><A><L><P><F><F><I><L><T><S><V><L><G><I><L><A><S><S><T><V><L><F><M><L><F><R><P><L><F><R><W><Q><L><C><P><G><W><P><V><L><A><Q><L><A><V><G><S><A><L><F><S><I><V><V><P><V><L><A><P><G><L><G><S><T><R><S><S><A><L><C><S><L><G><Y><C><V><W><Y><G><S><A><F><A><Q><A><L><L><L><G><C><H><A><S><L><G><H><R><L><G><A><G><Q><V><P><G><L><T><L><G><L><T><V><G><I><W><G><V><A><A><L><L><T><L><P><V><T><L><A><S><G><A><S><G><G><L><C><T><L><I><Y><S><T><E><L><K><A><L><Q><A><T><H><T><V><A><C><L><A><I><F><V><L><L><P><L><G><L><F><G><A><K><G><L><K><K><A><L><G><M><G><P><G><P><W><M><N><I><L><W><A><W><F><I><F><W><W><P><H><G><V><V><L><G><L><D><F><L><V><R><S><K><L><L><L><L><S><T><C><L><A><Q><Q><A><L><D><L><L><L><N><L><A><E><A><L><A><I><L><H><C><V><A><T><P><L><L><L><A><L><F><C><H><Q><A><T><R><T><L><L><P><S><L><P><L><P><E><G><W><S><S><H><L><D><T><L><G><S><K><S>
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines
Q16570
P33992
MCM5_HUMAN
P1-CDC46
Homo
<M><S><G><F><D><D><P><G><I><F><Y><S><D><S><F><G><G><D><A><Q><A><D><E><G><Q><A><R><K><S><Q><L><Q><R><R><F><K><E><F><L><R><Q><Y><R><V><G><T><D><R><T><G><F><T><F><K><Y><R><D><E><L><K><R><H><Y><N><L><G><E><Y><W><I><E><V><E><M><E><D><L><A><S><F><D><E><D><L><A><D><Y><L><Y><K><Q><P><A><E><H><L><Q><L><L><E><E><A><A><K><E><V><A><D><E><V><T><R><P><R><P><S><G><E><E><V><L><Q><D><I><Q><V><M><L><K><S><D><A><S><P><S><S><I><R><S><L><K><S><D><M><M><S><H><L><V><K><I><P><G><I><I><I><A><A><S><A><V><R><A><K><A><T><R><I><S><I><Q><C><R><S><C><R><N><T><L><T><N><I><A><M><R><P><G><L><E><G><Y><A><L><P><R><K><C><N><T><D><Q><A><G><R><P><K><C><P><L><D><P><Y><F><I><M><P><D><K><C><K><C><V><D><F><Q><T><L><K><L><Q><E><L><P><D><A><V><P><H><G><E><M><P><R><H><M><Q><L><Y><C><D><R><Y><L><C><D><K><V><V><P><G><N><R><V><T><I><M><G><I><Y><S><I><K><K><F><G><L><T><T><S><R><G><R><D><R><V><G><V><G><I><R><S><S><Y><I><R><V><L><G><I><Q><V><D><T><D><G><S><G><R><S><F><A><G><A><V><S><P><Q><E><E><E><E><F><R><R><L><A><A><L><P><N><V><Y><E><V><I><S><K><S><I><A><P><S><I><F><G><G><T><D><M><K><K><A><I><A><C><L><L><F><G><G><S><R><K><R><L><P><D><G><L><T><R><R><G><D><I><N><L><L><M><L><G><D><P><G><T><A><K><S><Q><L><L><K><F><V><E><K><C><S><P><I><G><V><Y><T><S><G><K><G><S><S><A><A><G><L><T><A><S><V><M><R><D><P><S><S><R><N><F><I><M><E><G><G><A><M><V><L><A><D><G><G><V><V><C><I><D><E><F><D><K><M><R><E><D><D><R><V><A><I><H><E><A><M><E><Q><Q><T><I><S><I><A><K><A><G><I><T><T><T><L><N><S><R><C><S><V><L><A><A><A><N><S><V><F><G><R><W><D><E><T><K><G><E><D><N><I><D><F><M><P><T><I><L><S><R><F><D><M><I><F><I><V><K><D><E><H><N><E><E><R><D><V><M><L><A><K><H><V><I><T><L><H><V><S><A><L><T><Q><T><Q><A><V><E><G><E><I><D><L><A><K><L><K><K><F><I><A><Y><C><R><V><K><C><G><P><R><L><S><A><E><A><A><E><K><L><K><N><R><Y><I><I><M><R><S><G><A><R><Q><H><E><R><D><S><D><R><R><S><S><I><P><I><T><V><R><Q><L><E><A><I><V><R><I><A><E><A><L><S><K><M><K><L><Q><P><F><A><T><E><A><D><V><E><E><A><L><R><L><F><Q><V><S><T><L><D><A><A><L><S><G><T><L><S><G><V><E><G><F><T><S><Q><E><D><Q><E><M><L><S><R><I><E><K><Q><L><K><R><R><F><A><I><G><S><Q><V><S><E><H><S><I><I><K><D><F><T><K><Q><K><Y><P><E><H><A><I><H><K><V><L><Q><L><M><L><R><R><G><E><I><Q><H><R><M><Q><R><K><V><L><Y><R><L><K>
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity .<BOP>
P33992
Q8NFU1
BEST2_HUMAN
Vitelliform macular dystrophy 2-like protein 1
Homo
<M><T><V><T><Y><T><A><R><V><A><N><A><R><F><G><G><F><S><Q><L><L><L><L><W><R><G><S><I><Y><K><L><L><W><R><E><L><L><C><F><L><G><F><Y><M><A><L><S><A><A><Y><R><F><V><L><T><E><G><Q><K><R><Y><F><E><K><L><V><I><Y><C><D><Q><Y><A><S><L><I><P><V><S><F><V><L><G><F><Y><V><T><L><V><V><N><R><W><W><S><Q><Y><L><C><M><P><L><P><D><A><L><M><C><V><V><A><G><T><V><H><G><R><D><D><R><G><R><L><Y><R><R><T><L><M><R><Y><A><G><L><S><A><V><L><I><L><R><S><V><S><T><A><V><F><K><R><F><P><T><I><D><H><V><V><E><A><G><F><M><T><R><E><E><R><K><K><F><E><N><L><N><S><S><Y><N><K><Y><W><V><P><C><V><W><F><S><N><L><A><A><Q><A><R><R><E><G><R><I><R><D><N><S><A><L><K><L><L><L><E><E><L><N><V><F><R><G><K><C><G><M><L><F><H><Y><D><W><I><S><V><P><L><V><Y><T><Q><V><V><T><I><A><L><Y><S><Y><F><L><A><C><L><I><G><R><Q><F><L><D><P><A><Q><G><Y><K><D><H><D><L><D><L><C><V><P><I><F><T><L><L><Q><F><F><F><Y><A><G><W><L><K><V><A><E><Q><L><I><N><P><F><G><E><D><D><D><D><F><E><T><N><F><L><I><D><R><N><F><Q><V><S><M><L><A><V><D><E><M><Y><D><D><L><A><V><L><E><K><D><L><Y><W><D><A><A><E><A><R><A><P><Y><T><A><A><T><V><F><Q><L><R><Q><P><S><F><Q><G><S><T><F><D><I><T><L><A><K><E><D><M><Q><F><Q><R><L><D><G><L><D><G><P><M><G><E><A><P><G><D><F><L><Q><R><L><L><P><A><G><A><G><M><V><A><G><G><P><L><G><R><R><L><S><F><L><L><R><K><N><S><C><V><S><E><A><S><T><G><A><S><C><S><C><A><V><V><P><E><G><A><A><P><E><C><S><C><G><D><P><L><L><D><P><G><L><P><E><P><E><A><P><P><P><A><G><P><E><P><L><T><L><I><P><G><P><V><E><P><F><S><I><V><T><M><P><G><P><R><G><P><A><P><P><W><L><P><S><P><I><G><E><E><E><E><N><L><A>
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.<BOP>
Q8NFU1
Q969L2
MAL2_HUMAN
Protein MAL2
Homo
<M><S><A><G><G><A><S><V><P><P><P><P><N><P><A><V><S><F><P><P><P><R><V><T><L><P><A><G><P><D><I><L><R><T><Y><S><G><A><F><V><C><L><E><I><L><F><G><G><L><V><W><I><L><V><A><S><S><N><V><P><L><P><L><L><Q><G><W><V><M><F><V><S><V><T><A><F><F><F><S><L><L><F><L><G><M><F><L><S><G><M><V><A><Q><I><D><A><N><W><N><F><L><D><F><A><Y><H><F><T><V><F><V><F><Y><F><G><A><F><L><L><E><A><A><A><T><S><L><H><D><L><H><C><N><T><T><I><T><G><Q><P><L><L><S><D><N><Q><Y><N><I><N><V><A><A><S><I><F><A><F><M><T><T><A><C><Y><G><C><S><L><G><L><A><L><R><R><W><R><P>
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.<BOP>
Q969L2
Q9BXS4
TMM59_HUMAN
Liver membrane-bound protein
Homo
<M><A><A><P><K><G><S><L><W><V><R><T><Q><L><G><L><P><P><L><L><L><L><T><M><A><L><A><G><G><S><G><T><A><S><A><E><A><F><D><S><V><L><G><D><T><A><S><C><H><R><A><C><Q><L><T><Y><P><L><H><T><Y><P><K><E><E><E><L><Y><A><C><Q><R><G><C><R><L><F><S><I><C><Q><F><V><D><D><G><I><D><L><N><R><T><K><L><E><C><E><S><A><C><T><E><A><Y><S><Q><S><D><E><Q><Y><A><C><H><L><G><C><Q><N><Q><L><P><F><A><E><L><R><Q><E><Q><L><M><S><L><M><P><K><M><H><L><L><F><P><L><T><L><V><R><S><F><W><S><D><M><M><D><S><A><Q><S><F><I><T><S><S><W><T><F><Y><L><Q><A><D><D><G><K><I><V><I><F><Q><S><K><P><E><I><Q><Y><A><P><H><L><E><Q><E><P><T><N><L><R><E><S><S><L><S><K><M><S><Y><L><Q><M><R><N><S><Q><A><H><R><N><F><L><E><D><G><E><S><D><G><F><L><R><C><L><S><L><N><S><G><W><I><L><T><T><T><L><V><L><S><V><M><V><L><L><W><I><C><C><A><T><V><A><T><A><V><E><Q><Y><V><P><S><E><K><L><S><I><Y><G><D><L><E><F><M><N><E><Q><K><L><N><R><Y><P><A><S><S><L><V><V><V><R><S><K><T><E><D><H><E><E><A><G><P><L><P><T><K><V><N><L><A><H><S><E><I>
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy . Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP . Inhibits APP transport to the cell surface and further shedding .<BOP>
Q9BXS4
P62684
GA113_HUMAN
HERV-K_19p13.11 provirus ancestral Gag polyprotein
Homo
<M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><V><S><V><S><D><A><P><G><S><C><I><I><D><C><N><E><K><T><R><K><K><S><Q><K><E><T><E><S><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><A><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><M><G><P><S><E><S><K><P><R><G><T><S><P><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><Q><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><Q><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><L><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><M><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><M><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><G><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><P><P><Q><A><A><V><Q><Q>
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP>
P62684
Q9BSK0
MALD1_HUMAN
MARVEL domain-containing protein 1
Homo
<M><L><P><P><P><P><R><Q><P><P><P><Q><A><R><A><A><R><G><A><V><R><L><Q><R><P><F><L><R><S><P><L><G><V><L><R><L><L><Q><L><L><A><G><A><A><F><W><I><T><I><A><T><S><K><Y><Q><G><P><V><H><F><A><L><F><V><S><V><L><F><W><L><L><T><L><G><L><Y><F><L><T><L><L><G><K><H><E><L><V><P><V><L><G><S><R><W><L><M><V><N><V><A><H><D><V><L><A><A><A><L><Y><G><A><A><T><G><I><M><S><D><Q><M><Q><R><H><S><Y><C><N><L><K><D><Y><P><L><P><C><A><Y><H><A><F><L><A><A><A><V><C><G><G><V><C><H><G><L><Y><L><L><S><A><L><Y><G><C><G><R><R><C><Q><G><K><Q><E><V><A>
Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.<BOP>
Q9BSK0
Q53T94
TAF1B_HUMAN
Transcription initiation factor SL1/TIF-IB subunit B
Homo
<M><D><L><E><E><A><E><E><F><K><E><R><C><T><Q><C><A><A><V><S><W><G><L><T><D><E><G><K><Y><Y><C><T><S><C><H><N><V><T><E><R><Y><Q><E><V><T><N><T><D><L><I><P><N><T><Q><I><K><A><L><N><R><G><L><K><K><K><N><N><T><E><K><G><W><D><W><Y><V><C><E><G><F><Q><Y><I><L><Y><Q><Q><A><E><A><L><K><N><L><G><V><G><P><E><L><K><N><D><V><L><H><N><F><W><K><R><Y><L><Q><K><S><K><Q><A><Y><C><K><N><P><V><Y><T><T><G><R><K><P><T><V><L><E><D><N><L><S><H><S><D><W><A><S><E><P><E><L><L><S><D><V><S><C><P><P><F><L><E><S><G><A><E><S><Q><S><D><I><H><T><R><K><P><F><P><V><S><K><A><S><Q><S><E><T><S><V><C><S><G><S><L><D><G><V><E><Y><S><Q><R><K><E><K><G><I><V><K><M><T><M><P><Q><T><L><A><F><C><Y><L><S><L><L><W><Q><R><E><A><I><T><L><S><D><L><L><R><F><V><E><E><D><H><I><P><Y><I><N><A><F><Q><H><F><P><E><Q><M><K><L><Y><G><R><D><R><G><I><F><G><I><E><S><W><P><D><Y><E><D><I><Y><K><K><T><V><E><V><G><T><F><L><D><L><P><R><F><P><D><I><T><E><D><C><Y><L><H><P><N><I><L><C><M><K><Y><L><M><E><V><N><L><P><D><E><M><H><S><L><T><C><H><V><V><K><M><T><G><M><G><E><V><D><F><L><T><F><D><P><I><A><K><M><A><K><T><V><K><Y><D><V><Q><A><V><A><I><I><V><V><V><L><K><L><L><F><L><L><D><D><S><F><E><W><S><L><S><N><L><A><E><K><H><N><E><K><N><K><K><D><K><P><W><F><D><F><R><K><W><Y><Q><I><M><K><K><A><F><D><E><K><K><Q><K><W><E><E><A><R><A><K><Y><L><W><K><S><E><K><P><L><Y><Y><S><F><V><D><K><P><V><A><Y><K><K><R><E><M><V><V><N><L><Q><K><Q><F><S><T><L><V><E><S><T><A><T><A><G><K><K><S><P><S><S><F><Q><F><N><W><T><E><E><D><T><D><R><T><C><F><H><G><H><S><L><Q><G><V><L><K><E><K><G><Q><S><L><L><T><K><N><S><L><Y><W><L><S><T><Q><K><F><C><R><C><Y><C><T><H><V><T><T><Y><E><E><S><N><Y><S><L><S><Y><Q><F><I><L><N><L><F><S><F><L><L><R><I><K><T><S><L><L><H><E><E><V><S><L><V><E><K><K><L><F><E><K><K><Y><S><V><K><R><K><K><S><R><S><K><K><V><R><R><H>
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.<BOP>
Q53T94
Q96NB1
CEP20_HUMAN
null
Homo
<M><A><T><V><A><E><L><K><A><V><L><K><D><T><L><E><K><K><G><V><L><G><H><L><K><A><R><I><R><A><E><V><F><N><A><L><D><D><D><R><E><P><R><P><S><L><S><H><E><N><L><L><I><N><E><L><I><R><E><Y><L><E><F><N><K><Y><K><Y><T><A><S><V><L><I><A><E><S><G><Q><P><V><V><P><L><D><R><Q><F><L><I><H><E><L><N><A><F><E><E><S><K><D><N><T><I><P><L><L><Y><G><I><L><A><H><F><L><R><G><T><K><D><G><I><Q><N><A><F><L><K><G><P><S><L><Q><P><S><D><P><S><L><G><R><Q><P><S><R><R><K><P><M><D><D><H><L><R><K><E><E><Q><K><S><T><N><I><E><D><L><H><V><S><Q><A><V><N><R>
Involved in the biogenesis of cilia . Required for the recruitment of PLK1 to centrosomes and S phase progression .<BOP>
Q96NB1
Q8TAA3
PSMA8_HUMAN
Proteasome subunit alpha-type 7-like
Homo
<M><A><S><R><Y><D><R><A><I><T><V><F><S><P><D><G><H><L><F><Q><V><E><Y><A><Q><E><A><V><K><K><G><S><T><A><V><G><I><R><G><T><N><I><V><V><L><G><V><E><K><K><S><V><A><K><L><Q><D><E><R><T><V><R><K><I><C><A><L><D><D><H><V><C><M><A><F><A><V><L><T><I><F><I><G><L><T><A><D><A><R><V><V><I><N><R><A><R><V><E><C><Q><S><H><K><L><T><V><E><D><P><V><T><V><E><Y><I><T><R><F><I><A><T><L><K><Q><K><Y><T><Q><S><N><G><R><R><P><F><G><I><S><A><L><I><V><G><F><D><D><D><G><I><S><R><L><Y><Q><T><D><P><S><G><T><Y><H><A><W><K><A><N><A><I><G><R><S><A><K><T><V><R><E><F><L><E><K><N><Y><T><E><D><A><I><A><S><D><S><E><A><I><K><L><A><I><K><A><L><L><E><V><V><Q><S><G><G><K><N><I><E><L><A><I><I><R><R><N><Q><P><L><K><M><F><S><A><K><E><V><E><L><Y><V><T><E><I><E><K><E><K><E><E><A><E><K><K><K><S><K><K><S><V>
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.<BOP>
Q8TAA3
Q8NI38
IKBD_HUMAN
TA-NFKBH
Homo
<M><E><A><G><P><W><R><V><S><A><P><P><S><G><P><P><Q><F><P><A><V><V><P><G><P><S><L><E><V><A><R><A><H><M><L><A><L><G><P><Q><Q><L><L><A><Q><D><E><E><G><D><T><L><L><H><L><F><A><A><R><G><L><R><W><A><A><Y><A><A><A><E><V><L><Q><V><Y><R><R><L><D><I><R><E><H><K><G><K><T><P><L><L><V><A><A><A><A><N><Q><P><L><I><V><E><D><L><L><N><L><G><A><E><P><N><A><A><D><H><Q><G><R><S><V><L><H><V><A><A><T><Y><G><L><P><G><V><L><L><A><V><L><N><S><G><V><Q><V><D><L><E><A><R><D><F><E><G><L><T><P><L><H><T><A><I><L><A><L><N><V><A><M><R><P><S><D><L><C><P><R><V><L><S><T><Q><A><R><D><R><L><D><C><V><H><M><L><L><Q><M><G><A><N><H><T><S><Q><E><I><K><S><N><K><T><V><L><H><L><A><V><Q><A><A><N><P><T><L><V><Q><L><L><L><E><L><P><R><G><D><L><R><T><F><V><N><M><K><A><H><G><N><T><A><L><H><M><A><A><A><L><P><P><G><P><A><Q><E><A><I><V><R><H><L><L><A><A><G><A><D><P><T><L><R><N><L><E><N><E><Q><P><V><H><L><L><R><P><G><P><G><P><E><G><L><R><Q><L><L><K><R><S><R><V><A><P><P><G><L><S><S>
Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes.<BOP>
Q8NI38
Q9BSL1
UBAC1_HUMAN
Kip1 ubiquitination-promoting complex protein 2
Homo
<M><F><V><Q><E><E><K><I><F><A><G><K><V><L><R><L><H><I><C><A><S><D><G><A><E><W><L><E><E><A><T><E><D><T><S><V><E><K><L><K><E><R><C><L><K><H><C><A><H><G><S><L><E><D><P><K><S><I><T><H><H><K><L><I><H><A><A><S><E><R><V><L><S><D><A><R><T><I><L><E><E><N><I><Q><D><Q><D><V><L><L><L><I><K><K><R><A><P><S><P><L><P><K><M><A><D><V><S><A><E><E><K><K><K><Q><D><Q><K><A><P><D><K><E><A><I><L><R><A><T><A><N><L><P><S><Y><N><M><D><R><A><A><V><Q><T><N><M><R><D><F><Q><T><E><L><R><K><I><L><V><S><L><I><E><V><A><Q><K><L><L><A><L><N><P><D><A><V><E><L><F><K><K><A><N><A><M><L><D><E><D><E><D><E><R><V><D><E><A><A><L><R><Q><L><T><E><M><G><F><P><E><N><R><A><T><K><A><L><Q><L><N><H><M><S><V><P><Q><A><M><E><W><L><I><E><H><A><E><D><P><T><I><D><T><P><L><P><G><Q><A><P><P><E><A><E><G><A><T><A><A><A><S><E><A><A><A><G><A><S><A><T><D><E><E><A><R><D><E><L><T><E><I><F><K><K><I><R><R><K><R><E><F><R><A><D><A><R><A><V><I><S><L><M><E><M><G><F><D><E><K><E><V><I><D><A><L><R><V><N><N><N><Q><Q><N><A><A><C><E><W><L><L><G><D><R><K><P><S><P><E><E><L><D><K><G><I><D><P><D><S><P><L><F><Q><A><I><L><D><N><P><V><V><Q><L><G><L><T><N><P><K><T><L><L><A><F><E><D><M><L><E><N><P><L><N><S><T><Q><W><M><N><D><P><E><T><G><P><V><M><L><Q><I><S><R><I><F><Q><T><L><N><R><T>
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<BOP>
Q9BSL1
Q5SXM8
DNLZ_HUMAN
mtHsp70-escort protein
Homo
<M><L><R><T><A><L><R><G><A><P><R><L><L><S><R><V><Q><P><R><A><P><C><L><R><R><L><W><G><R><G><A><R><P><E><V><A><G><R><R><R><A><W><A><W><G><W><R><R><S><S><S><E><Q><G><P><G><P><A><A><A><L><G><R><V><E><A><A><H><Y><Q><L><V><Y><T><C><K><V><C><G><T><R><S><S><K><R><I><S><K><L><A><Y><H><Q><G><V><V><I><V><T><C><P><G><C><Q><N><H><H><I><I><A><D><N><L><G><W><F><S><D><L><N><G><K><R><N><I><E><E><I><L><T><A><R><G><E><Q><V><H><R><V><A><G><E><G><A><L><E><L><V><L><E><A><A><G><A><P><T><S><T><A><A><P><E><A><G><E><D><E><G><P><P><S><P><G><K><T><E><P><S>
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.<BOP>
Q5SXM8
O60235
TM11D_HUMAN
Transmembrane protease serine 11D catalytic chain
Homo
<M><Y><R><P><A><R><V><T><S><T><S><R><F><L><N><P><Y><V><V><C><F><I><V><V><A><G><V><V><I><L><A><V><T><I><A><L><L><V><Y><F><L><A><F><D><Q><K><S><Y><F><Y><R><S><S><F><Q><L><L><N><V><E><Y><N><S><Q><L><N><S><P><A><T><Q><E><Y><R><T><L><S><G><R><I><E><S><L><I><T><K><T><F><K><E><S><N><L><R><N><Q><F><I><R><A><H><V><A><K><L><R><Q><D><G><S><G><V><R><A><D><V><V><M><K><F><Q><F><T><R><N><N><N><G><A><S><M><K><S><R><I><E><S><V><L><R><Q><M><L><N><N><S><G><N><L><E><I><N><P><S><T><E><I><T><S><L><T><D><Q><A><A><A><N><W><L><I><N><E><C><G><A><G><P><D><L><I><T><L><S><E><Q><R><I><L><G><G><T><E><A><E><E><G><S><W><P><W><Q><V><S><L><R><L><N><N><A><H><H><C><G><G><S><L><I><N><N><M><W><I><L><T><A><A><H><C><F><R><S><N><S><N><P><R><D><W><I><A><T><S><G><I><S><T><T><F><P><K><L><R><M><R><V><R><N><I><L><I><H><N><N><Y><K><S><A><T><H><E><N><D><I><A><L><V><R><L><E><N><S><V><T><F><T><K><D><I><H><S><V><C><L><P><A><A><T><Q><N><I><P><P><G><S><T><A><Y><V><T><G><W><G><A><Q><E><Y><A><G><H><T><V><P><E><L><R><Q><G><Q><V><R><I><I><S><N><D><V><C><N><A><P><H><S><Y><N><G><A><I><L><S><G><M><L><C><A><G><V><P><Q><G><G><V><D><A><C><Q><G><D><S><G><G><P><L><V><Q><E><D><S><R><R><L><W><F><I><V><G><I><V><S><W><G><D><Q><C><G><L><P><D><K><P><G><V><Y><T><R><V><T><A><Y><L><D><W><I><R><Q><Q><T><G><I>
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.<BOP>
O60235
O95257
GA45G_HUMAN
DNA damage-inducible transcript 2 protein
Homo
<M><T><L><E><E><V><R><G><Q><D><T><V><P><E><S><T><A><R><M><Q><G><A><G><K><A><L><H><E><L><L><L><S><A><Q><R><Q><G><C><L><T><A><G><V><Y><E><S><A><K><V><L><N><V><D><P><D><N><V><T><F><C><V><L><A><A><G><E><E><D><E><G><D><I><A><L><Q><I><H><F><T><L><I><Q><A><F><C><C><E><N><D><I><D><I><V><R><V><G><D><V><Q><R><L><A><A><I><V><G><A><G><E><E><A><G><A><P><G><D><L><H><C><I><L><I><S><N><P><N><E><D><A><W><K><D><P><A><L><E><K><L><S><L><F><C><E><E><S><R><S><V><N><D><W><V><P><S><I><T><L><P><E>
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.<BOP>
O95257
P80217
IN35_HUMAN
Interferon-induced 35 kDa protein
Homo
<M><S><A><P><L><D><A><A><L><H><A><L><Q><E><E><Q><A><R><L><K><M><R><L><W><D><L><Q><Q><L><R><K><E><L><G><D><S><P><K><D><K><V><P><F><S><V><P><K><I><P><L><V><F><R><G><H><T><Q><Q><D><P><E><V><P><K><S><L><V><S><N><L><R><I><H><C><P><L><L><A><G><S><A><L><I><T><F><D><D><P><K><V><A><E><Q><V><L><Q><Q><K><E><H><T><I><N><M><E><E><C><R><L><R><V><Q><V><Q><P><L><E><L><P><M><V><T><T><I><Q><M><S><S><Q><L><S><G><R><R><V><L><V><T><G><F><P><A><S><L><R><L><S><E><E><E><L><L><D><K><L><E><I><F><F><G><K><T><R><N><G><G><G><D><V><D><V><R><E><L><L><P><G><S><V><M><L><G><F><A><R><D><G><V><A><Q><R><L><C><Q><I><G><Q><F><T><V><P><L><G><G><Q><Q><V><P><L><R><V><S><P><Y><V><N><G><E><I><Q><K><A><E><I><R><S><Q><P><V><P><R><S><V><L><V><L><N><I><P><D><I><L><D><G><P><E><L><H><D><V><L><E><I><H><F><Q><K><P><T><R><G><G><G><E><V><E><A><L><T><V><V><P><Q><G><Q><Q><G><L><A><V><F><T><S><E><S><G>
Acts as a signaling pathway regulator involved in innate immune system response . In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation . In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production . In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries . Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion . Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines .
P80217
P53611
PGTB2_HUMAN
Type II protein geranyl-geranyltransferase subunit beta
Homo
<M><G><T><P><Q><K><D><V><I><I><K><S><D><A><P><D><T><L><L><L><E><K><H><A><D><Y><I><A><S><Y><G><S><K><K><D><D><Y><E><Y><C><M><S><E><Y><L><R><M><S><G><I><Y><W><G><L><T><V><M><D><L><M><G><Q><L><H><R><M><N><R><E><E><I><L><A><F><I><K><S><C><Q><H><E><C><G><G><I><S><A><S><I><G><H><D><P><H><L><L><Y><T><L><S><A><V><Q><I><L><T><L><Y><D><S><I><N><V><I><D><V><N><K><V><V><E><Y><V><K><G><L><Q><K><E><D><G><S><F><A><G><D><I><W><G><E><I><D><T><R><F><S><F><C><A><V><A><T><L><A><L><L><G><K><L><D><A><I><N><V><E><K><A><I><E><F><V><L><S><C><M><N><F><D><G><G><F><G><C><R><P><G><S><E><S><H><A><G><Q><I><Y><C><C><T><G><F><L><A><I><T><S><Q><L><H><Q><V><N><S><D><L><L><G><W><W><L><C><E><R><Q><L><P><S><G><G><L><N><G><R><P><E><K><L><P><D><V><C><Y><S><W><W><V><L><A><S><L><K><I><I><G><R><L><H><W><I><D><R><E><K><L><R><N><F><I><L><A><C><Q><D><E><E><T><G><G><F><A><D><R><P><G><D><M><V><D><P><F><H><T><L><F><G><I><A><G><L><S><L><L><G><E><E><Q><I><K><P><V><N><P><V><F><C><M><P><E><E><V><L><Q><R><V><N><V><Q><P><E><L><V><S>
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.<BOP>
P53611
Q9NUJ1
ABHDA_HUMAN
Mycophenolic acid acyl-glucuronide esterase, mitochondrial
Homo
<M><A><V><A><R><L><A><A><V><A><A><W><V><P><C><R><S><W><G><W><A><A><V><P><F><G><P><H><R><G><L><S><V><L><L><A><R><I><P><Q><R><A><P><R><W><L><P><A><C><R><Q><K><T><S><L><S><F><L><N><R><P><D><L><P><N><L><A><Y><K><K><L><K><G><K><S><P><G><I><I><F><I><P><G><Y><L><S><Y><M><N><G><T><K><A><L><A><I><E><E><F><C><K><S><L><G><H><A><C><I><R><F><D><Y><S><G><V><G><S><S><D><G><N><S><E><E><S><T><L><G><K><W><R><K><D><V><L><S><I><I><D><D><L><A><D><G><P><Q><I><L><V><G><S><S><L><G><G><W><L><M><L><H><A><A><I><A><R><P><E><K><V><V><A><L><I><G><V><A><T><A><A><D><T><L><V><T><K><F><N><Q><L><P><V><E><L><K><K><E><V><E><M><K><G><V><W><S><M><P><S><K><Y><S><E><E><G><V><Y><N><V><Q><Y><S><F><I><K><E><A><E><H><H><C><L><L><H><S><P><I><P><V><N><C><P><I><R><L><L><H><G><M><K><D><D><I><V><P><W><H><T><S><M><Q><V><A><D><R><V><L><S><T><D><V><D><V><I><L><R><K><H><S><D><H><R><M><R><E><K><A><D><I><Q><L><L><V><Y><T><I><D><D><L><I><D><K><L><S><T><I><V><N>
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins . Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability . Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate .<BOP>
Q9NUJ1
Q9UKI2
BORG2_HUMAN
MSE55-related Cdc42-binding protein
Homo
<M><P><A><K><T><P><I><Y><L><K><A><A><N><N><K><K><G><K><K><F><K><L><R><D><I><L><S><P><D><M><I><S><P><P><L><G><D><F><R><H><T><I><H><I><G><K><E><G><Q><H><D><V><F><G><D><I><S><F><L><Q><G><N><Y><E><L><L><P><G><N><Q><E><K><A><H><L><G><Q><F><P><G><H><N><E><F><F><R><A><N><S><T><S><D><S><V><F><T><E><T><P><S><P><V><L><K><N><A><I><S><L><P><T><I><G><G><S><Q><A><L><M><L><P><L><L><S><P><V><T><F><N><S><K><Q><E><S><F><G><P><A><K><L><P><R><L><S><C><E><P><V><M><E><E><K><A><Q><E><K><S><S><L><L><E><N><G><T><V><H><Q><G><D><T><S><W><G><S><S><G><S><A><S><Q><S><S><Q><G><R><D><S><H><S><S><S><L><S><E><Q><Y><P><D><W><P><A><E><D><M><F><D><H><P><T><P><C><E><L><I><K><G><K><T><K><S><E><E><S><L><S><D><L><T><G><S><L><L><S><L><Q><L><D><L><G><P><S><L><L><D><E><V><L><N><V><M><D><K><N><K>
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.<BOP>
Q9UKI2
P68871
HBB_HUMAN
Spinorphin
Homo
<M><V><H><L><T><P><E><E><K><S><A><V><T><A><L><W><G><K><V><N><V><D><E><V><G><G><E><A><L><G><R><L><L><V><V><Y><P><W><T><Q><R><F><F><E><S><F><G><D><L><S><T><P><D><A><V><M><G><N><P><K><V><K><A><H><G><K><K><V><L><G><A><F><S><D><G><L><A><H><L><D><N><L><K><G><T><F><A><T><L><S><E><L><H><C><D><K><L><H><V><D><P><E><N><F><R><L><L><G><N><V><L><V><C><V><L><A><H><H><F><G><K><E><F><T><P><P><V><Q><A><A><Y><Q><K><V><V><A><G><V><A><N><A><L><A><H><K><Y><H>
Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.<BOP>
P68871
Q9GZX6
IL22_HUMAN
IL-10-related T-cell-derived-inducible factor
Homo
<M><A><A><L><Q><K><S><V><S><S><F><L><M><G><T><L><A><T><S><C><L><L><L><L><A><L><L><V><Q><G><G><A><A><A><P><I><S><S><H><C><R><L><D><K><S><N><F><Q><Q><P><Y><I><T><N><R><T><F><M><L><A><K><E><A><S><L><A><D><N><N><T><D><V><R><L><I><G><E><K><L><F><H><G><V><S><M><S><E><R><C><Y><L><M><K><Q><V><L><N><F><T><L><E><E><V><L><F><P><Q><S><D><R><F><Q><P><Y><M><Q><E><V><V><P><F><L><A><R><L><S><N><R><L><S><T><C><H><I><E><G><D><D><L><H><I><Q><R><N><V><Q><K><L><K><D><T><V><K><K><L><G><E><S><G><E><I><K><A><I><G><E><L><D><L><L><F><M><S><L><R><N><A><C><I>
Cytokine that plays a critical role in modulating tissue responses during inflammation . Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage . Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB . Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways .<BOP>
Q9GZX6
Q8IZM9
S38A6_HUMAN
Solute carrier family 38 member 6
Homo
<M><E><A><S><W><G><S><F><N><A><E><R><G><W><Y><V><S><V><Q><Q><P><E><E><A><E><A><E><E><L><S><P><L><L><S><N><E><L><H><R><Q><R><S><P><G><V><S><F><G><L><S><V><F><N><L><M><N><A><I><M><G><S><G><I><L><G><L><A><Y><V><L><A><N><T><G><V><F><G><F><S><F><L><L><L><T><V><A><L><L><A><S><Y><S><V><H><L><L><L><S><M><C><I><Q><T><A><V><T><S><Y><E><D><L><G><L><F><A><F><G><L><P><G><K><L><V><V><A><G><T><I><I><I><Q><N><I><G><A><M><S><S><Y><L><L><I><I><K><T><E><L><P><A><A><I><A><E><F><L><T><G><D><Y><S><R><Y><W><Y><L><D><G><Q><T><L><L><I><I><I><C><V><G><I><V><F><P><L><A><L><L><P><K><I><G><F><L><G><Y><T><S><S><L><S><F><F><F><M><M><F><F><A><L><V><V><I><I><K><K><W><S><I><P><C><P><L><T><L><N><Y><V><E><K><G><F><Q><I><S><N><V><T><D><D><C><K><P><K><L><F><H><F><S><K><E><S><A><Y><A><L><P><T><M><A><F><S><F><L><C><H><T><S><I><L><P><I><Y><C><E><L><Q><S><P><S><K><K><R><M><Q><N><V><T><N><T><A><I><A><L><S><F><L><I><Y><F><I><S><A><L><F><G><Y><L><T><F><Y><D><K><V><E><S><E><L><L><K><G><Y><S><K><Y><L><S><H><D><V><V><V><M><T><V><K><L><C><I><L><F><A><V><L><L><T><V><P><L><I><H><F><P><A><R><K><A><V><T><M><M><F><F><S><N><F><P><F><S><W><I><R><H><F><L><I><T><L><A><L><N><I><I><I><V><L><L><A><I><Y><V><P><D><I><R><N><V><F><G><V><V><G><A><S><T><S><T><C><L><I><F><I><F><P><G><L><F><Y><L><K><L><S><R><E><D><F><L><S><W><K><K><L><G><A><F><V><L><L><I><F><G><I><L><V><G><N><F><S><L><A><L><I><I><F><D><W><I><N><K>
Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.<BOP>
Q8IZM9
Q58A44
PCOTH_HUMAN
C1QTNF9B antisense gene protein 1
Homo
<M><W><I><L><S><N><L><M><G><T><S><E><E><G><N><L><L><S><T><V><S><P><T><V><K><A><L><F><G><K><T><R><V><S><P><I><F><P><F><S><P><R><S><P><F><Q><P><L><I><P><R><T><P><G><S><P><W><G><P><V><G><P><A><S><P><L><G><P><G><F><P><I><G><P><M><G><P><G><K><P><V><G><P><K><G><P><M><L><P><L><G><P><S><G><P><V><G><P><T><S><P><L><F><P><F><C><P>
May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.<BOP>
Q58A44
Q96GD3
SCMH1_HUMAN
Sex comb on midleg homolog 1
Homo
<M><L><V><C><Y><S><V><L><A><C><E><I><L><W><D><L><P><C><S><I><M><G><S><P><L><G><H><F><T><W><D><K><Y><L><K><E><T><C><S><V><P><A><P><V><H><C><F><K><Q><S><Y><T><P><P><S><N><E><F><K><I><S><M><K><L><E><A><Q><D><P><R><N><T><T><S><T><C><I><A><T><V><V><G><L><T><G><A><R><L><R><L><R><L><D><G><S><D><N><K><N><D><F><W><R><L><V><D><S><A><E><I><Q><P><I><G><N><C><E><K><N><G><G><M><L><Q><P><P><L><G><F><R><L><N><A><S><S><W><P><M><F><L><L><K><T><L><N><G><A><E><M><A><P><I><R><I><F><H><K><E><P><P><S><P><S><H><N><F><F><K><M><G><M><K><L><E><A><V><D><R><K><N><P><H><F><I><C><P><A><T><I><G><E><V><R><G><S><E><V><L><V><T><F><D><G><W><R><G><A><F><D><Y><W><C><R><F><D><S><R><D><I><F><P><V><G><W><C><S><L><T><G><D><N><L><Q><P><P><G><T><K><V><V><I><P><K><N><P><Y><P><A><S><D><V><N><T><E><K><P><S><I><H><S><S><T><K><T><V><L><E><H><Q><P><G><Q><R><G><R><K><P><G><K><K><R><G><R><T><P><K><T><L><I><S><H><P><I><S><A><P><S><K><T><A><E><P><L><K><F><P><K><K><R><G><P><K><P><G><S><K><R><K><P><R><T><L><L><N><P><P><P><A><S><P><T><T><S><T><P><E><P><D><T><S><T><V><P><Q><D><A><A><T><I><P><S><S><A><M><Q><A><P><T><V><C><I><Y><L><N><K><N><G><S><T><G><P><H><L><D><K><K><K><V><Q><Q><L><P><D><H><F><G><P><A><R><A><S><V><V><L><Q><Q><A><V><Q><A><C><I><D><C><A><Y><H><Q><K><T><V><F><S><F><L><K><Q><G><H><G><G><E><V><I><S><A><V><F><D><R><E><Q><H><T><L><N><L><P><A><V><N><S><I><T><Y><V><L><R><F><L><E><K><L><C><H><N><L><R><S><D><N><L><F><G><N><Q><P><F><T><Q><T><H><L><S><L><T><A><I><E><Y><S><H><S><H><D><R><Y><L><P><G><E><T><F><V><L><G><N><S><L><A><R><S><L><E><P><H><S><D><S><M><D><S><A><S><N><P><T><N><L><V><S><T><S><Q><R><H><R><P><L><L><S><S><C><G><L><P><P><S><T><A><S><A><V><R><R><L><C><S><R><G><V><L><K><G><S><N><E><R><R><D><M><E><S><F><W><K><L><N><R><S><P><G><S><D><R><Y><L><E><S><R><D><A><S><R><L><S><G><R><D><P><S><S><W><T><V><E><D><V><M><Q><F><V><R><E><A><D><P><Q><L><G><P><H><A><D><L><F><R><K><H><E><I><D><G><K><A><L><L><L><L><R><S><D><M><M><M><K><Y><M><G><L><K><L><G><P><A><L><K><L><S><Y><H><I><D><R><L><K><Q><G><K><F>
Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.<BOP>
Q96GD3
Q9UHP7
CLC2D_HUMAN
Osteoclast inhibitory lectin
Homo
<M><H><D><S><N><N><V><E><K><D><I><T><P><S><E><L><P><A><N><P><G><C><L><H><S><K><E><H><S><I><K><A><T><L><I><W><R><L><F><F><L><I><M><F><L><T><I><I><V><C><G><M><V><A><A><L><S><A><I><R><A><N><C><H><Q><E><P><S><V><C><L><Q><A><A><C><P><E><S><W><I><G><F><Q><R><K><C><F><Y><F><S><D><D><T><K><N><W><T><S><S><Q><R><F><C><D><S><Q><D><A><D><L><A><Q><V><E><S><F><Q><E><L><N><F><L><L><R><Y><K><G><P><S><D><H><W><I><G><L><S><R><E><Q><G><Q><P><W><K><W><I><N><G><T><E><W><T><R><Q><F><P><I><L><G><A><G><E><C><A><Y><L><N><D><K><G><A><S><S><A><R><H><Y><T><E><R><K><W><I><C><S><K><S><D><I><H><V>
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis . Inhibits osteoclast formation . Inhibits bone resorption . Modulates the release of interferon-gamma . Binds high molecular weight sulfated glycosaminoglycans .<BOP>
Q9UHP7
P0C7X2
ZN688_HUMAN
Zinc finger protein 688
Homo
<M><A><P><P><P><A><P><L><L><A><P><R><P><G><E><T><R><P><G><C><R><K><P><G><T><V><S><F><A><D><V><A><V><Y><F><S><P><E><E><W><G><C><L><R><P><A><Q><R><A><L><Y><R><D><V><M><Q><E><T><Y><G><H><L><G><A><L><G><F><P><G><P><K><P><A><L><I><S><W><M><E><Q><E><S><E><A><W><S><P><A><A><Q><D><P><E><K><G><E><R><L><G><G><A><R><R><G><D><V><P><N><R><K><E><E><E><P><E><E><V><P><R><A><K><G><P><R><K><A><P><V><K><E><S><P><E><V><L><V><E><R><N><P><D><P><A><I><S><V><A><P><A><R><A><Q><P><P><K><N><A><A><W><D><P><T><T><G><A><Q><P><P><A><P><I><P><S><M><D><A><Q><A><G><Q><R><R><H><V><C><T><D><C><G><R><R><F><T><Y><P><S><L><L><V><S><H><R><R><M><H><S><G><E><R><P><F><P><C><P><E><C><G><M><R><F><K><R><K><F><A><V><E><A><H><Q><W><I><H><R><S><C><S><G><G><R><R><G><R><R><P><G><I><R><A><V><P><R><A><P><V><R><G><D><R><D><P><P><V><L><F><R><H><Y><P><D><I><F><E><E><C><G>
May be involved in transcriptional regulation.<BOP>
P0C7X2
Q8TD06
AGR3_HUMAN
Protein disulfide isomerase family A, member 18
Homo
<M><M><L><H><S><A><L><G><L><C><L><L><L><V><T><V><S><S><N><L><A><I><A><I><K><K><E><K><R><P><P><Q><T><L><S><R><G><W><G><D><D><I><T><W><V><Q><T><Y><E><E><G><L><F><Y><A><Q><K><S><K><K><P><L><M><V><I><H><H><L><E><D><C><Q><Y><S><Q><A><L><K><K><V><F><A><Q><N><E><E><I><Q><E><M><A><Q><N><K><F><I><M><L><N><L><M><H><E><T><T><D><K><N><L><S><P><D><G><Q><Y><V><P><R><I><M><F><V><D><P><S><L><T><V><R><A><D><I><A><G><R><Y><S><N><R><L><Y><T><Y><E><P><R><D><L><P><L><L><I><E><N><M><K><K><A><L><R><L><I><Q><S><E><L>
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.<BOP>
Q8TD06
Q96PI1
SPRR4_HUMAN
Small proline-rich protein 4
Homo
<M><S><S><Q><Q><Q><Q><R><Q><Q><Q><Q><C><P><P><Q><R><A><Q><Q><Q><Q><V><K><Q><P><C><Q><P><P><P><V><K><C><Q><E><T><C><A><P><K><T><K><D><P><C><A><P><Q><V><K><K><Q><C><P><P><K><G><T><I><I><P><A><Q><Q><K><C><P><S><A><Q><Q><A><S><K><S><K><Q><K>
Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.<BOP>
Q96PI1
Q9Y3D7
TIM16_HUMAN
Presequence translocated-associated motor subunit PAM16
Homo
<M><A><K><Y><L><A><Q><I><I><V><M><G><V><Q><V><V><G><R><A><F><A><R><A><L><R><Q><E><F><A><A><S><R><A><A><A><D><A><R><G><R><A><G><H><R><S><A><A><A><S><N><L><S><G><L><S><L><Q><E><A><Q><Q><I><L><N><V><S><K><L><S><P><E><E><V><Q><K><N><Y><E><H><L><F><K><V><N><D><K><S><V><G><G><S><F><Y><L><Q><S><K><V><V><R><A><K><E><R><L><D><E><E><L><K><I><Q><A><Q><E><D><R><E><K><G><Q><M><P><H><T>
Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.<BOP>
Q9Y3D7
Q7RTT4
SSX8_HUMAN
Putative protein SSX8
Homo
<M><N><G><D><D><A><F><A><K><R><P><R><D><D><D><K><A><S><E><K><R><S><K><A><F><N><D><I><A><T><Y><F><S><K><K><E><W><E><K><M><K><Y><S><E><K><I><S><Y><V><Y><M><K><R><N><Y><E><A><M><T><K><L><G><F><N><V><T><L><P><P><F><M><C><N><K><Q><A><T><D><F><Q><G><N><Y><F><D><N><D><R><N><R><R><I><Q><V><E><R><P><Q><M><T><F><G><R><L><Q><R><I><I><P><K><I><M><P><K><K><P><A><E><E><G><N><D><S><K><G><V><S><E><A><S><G><P><Q><N><D><G><K><Q><L><A><P><G><K><A><N><T><S><E><K><I><N><K><R><S><G><P><K><R><G><R><H><A><W><T><H><R><L><R><E><R><N><Q><L><V><I><Y><E><E><I><R><D><P><E><E><D><D><E>
Could act as a modulator of transcription.<BOP>
Q7RTT4
Q9NSP4
CENPM_HUMAN
Proliferation-associated nuclear element protein 1
Homo
<M><S><V><L><R><P><L><D><K><L><P><G><L><N><T><A><T><I><L><L><V><G><T><E><D><A><L><L><Q><Q><L><A><D><S><M><L><K><E><D><C><A><S><E><L><K><V><H><L><A><K><S><L><P><L><P><S><S><V><N><R><P><R><I><D><L><I><V><F><V><V><N><L><H><S><K><Y><S><L><Q><N><T><E><E><S><L><R><H><V><D><A><S><F><F><L><G><K><V><C><F><L><A><T><G><A><G><R><E><S><H><C><S><I><H><R><H><T><V><V><K><L><A><H><T><Y><Q><S><P><L><L><Y><C><D><L><E><V><E><G><F><R><A><T><M><A><Q><R><L><V><R><V><L><Q><I><C><A><G><H><V><P><G><V><S><A><L><N><L><L><S><L><L><R><S><S><E><G><P><S><L><E><D><L>
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.<BOP>
Q9NSP4
P30532
ACHA5_HUMAN
Neuronal acetylcholine receptor subunit alpha-5
Homo
<M><A><A><R><G><S><G><P><R><A><L><R><L><L><L><L><V><Q><L><V><A><G><R><C><G><L><A><G><A><A><G><G><A><Q><R><G><L><S><E><P><S><S><I><A><K><H><E><D><S><L><L><K><D><L><F><Q><D><Y><E><R><W><V><R><P><V><E><H><L><N><D><K><I><K><I><K><F><G><L><A><I><S><Q><L><V><D><V><D><E><K><N><Q><L><M><T><T><N><V><W><L><K><Q><E><W><I><D><V><K><L><R><W><N><P><D><D><Y><G><G><I><K><V><I><R><V><P><S><D><S><V><W><T><P><D><I><V><L><F><D><N><A><D><G><R><F><E><G><T><S><T><K><T><V><I><R><Y><N><G><T><V><T><W><T><P><P><A><N><Y><K><S><S><C><T><I><D><V><T><F><F><P><F><D><L><Q><N><C><S><M><K><F><G><S><W><T><Y><D><G><S><Q><V><D><I><I><L><E><D><Q><D><V><D><K><R><D><F><F><D><N><G><E><W><E><I><V><S><A><T><G><S><K><G><N><R><T><D><S><C><C><W><Y><P><Y><V><T><Y><S><F><V><I><K><R><L><P><L><F><Y><T><L><F><L><I><I><P><C><I><G><L><S><F><L><T><V><L><V><F><Y><L><P><S><N><E><G><E><K><I><C><L><C><T><S><V><L><V><S><L><T><V><F><L><L><V><I><E><E><I><I><P><S><S><S><K><V><I><P><L><I><G><E><Y><L><V><F><T><M><I><F><V><T><L><S><I><M><V><T><V><F><A><I><N><I><H><H><R><S><S><S><T><H><N><A><M><A><P><L><V><R><K><I><F><L><H><T><L><P><K><L><L><C><M><R><S><H><V><D><R><Y><F><T><Q><K><E><E><T><E><S><G><S><G><P><K><S><S><R><N><T><L><E><A><A><L><D><S><I><R><Y><I><T><R><H><I><M><K><E><N><D><V><R><E><V><V><E><D><W><K><F><I><A><Q><V><L><D><R><M><F><L><W><T><F><L><F><V><S><I><V><G><S><L><G><L><F><V><P><V><I><Y><K><W><A><N><I><L><I><P><V><H><I><G><N><A><N><K>
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP>
P30532
P10082
PYY_HUMAN
PYY-II
Homo
<M><V><F><V><R><R><P><W><P><A><L><T><T><V><L><L><A><L><L><V><C><L><G><A><L><V><D><A><Y><P><I><K><P><E><A><P><R><E><D><A><S><P><E><E><L><N><R><Y><Y><A><S><L><R><H><Y><L><N><L><V><T><R><Q><R><Y><G><K><R><D><G><P><D><T><L><L><S><K><T><F><F><P><D><G><E><D><R><P><V><R><S><R><S><E><G><P><D><L><W>
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.<BOP>
P10082
Q6ZR52
ZN493_HUMAN
Zinc finger protein 493
Homo
<M><N><E><C><N><V><H><K><E><G><Y><N><E><L><N><Q><Y><L><T><T><T><Q><S><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><L><L><N><S><N><R><H><N><T><K><H><T><G><K><K><P><F><K><C><K><K><C><G><K><S><F><C><M><L><L><H><L><C><Q><H><K><R><I><H><I><R><E><N><S><Y><R><C><E><E><C><G><K><A><F><I><W><F><S><T><L><T><R><H><R><R><V><H><T><G><E><K><S><Y><K><Y><E><C><G><K><S><F><N><Q><D><S><N><L><T><T><H><K><R><I><H><T><G><Q><K><P><Y><K><C><E><E><C><G><T><S><F><Y><Q><F><S><Y><L><T><R><H><K><L><I><H><T><R><E><K><P><Y><K><C><E><Q><Y><G><K><T><F><N><Q><S><S><T><L><T><G><H><K><I><I><H><N><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><I><F><S><T><P><T><K><H><K><I><I><H><T><E><E><K><S><H><R><C><E><E><Y><C><K><A><Y><K><E><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><I><F><S><T><L><T><K><H><K><I><I><H><T><E><E><K><S><H><R><C><E><E><C><G><K><A><Y><K><E><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><T><F><S><V><F><S><I><L><T><K><H><K><I><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><T><L><T><K><H><R><I><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><S><I><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><T><L><T><I><H><K><M><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><H><L><T><T><H><K><R><I><H><T><G><H><K><P><Y><K><C><K><E><C><G><K><S><F><S><V><F><S><T><L><T><K><H><K><I><I><H><T><D><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><I><L><S><I><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><H><L><A><G><H><K><Q><I><H><S><V><Q><K><P><Y><K><C><E><E><C><G><K><A><F><S><I><F><S><T><L><T><K><H><K><I><I><H><T><E><E><K><P><Y><K><C><E><K><C><G><K><T><F><Y><R><F><S><N><L><N><T><H><K><I><I><H><T><G><E><K><P><C><K><C><E><E><C><G><K><A><F><N><H><S><S><N><L><I><K><H><K><L><I><H><T><G><D><K><P><Y><K><C><E><A><C><G><K><A><F><R><R><S><S><H><L><S><R><H><K><I><I><H><I><G><I><H><T><E><E><T><V><Q><K>
May be involved in transcriptional regulation.<BOP>
Q6ZR52
Q07001
ACHD_HUMAN
Acetylcholine receptor subunit delta
Homo
<M><E><G><P><V><L><T><L><G><L><L><A><A><L><A><V><C><G><S><W><G><L><N><E><E><E><R><L><I><R><H><L><F><Q><E><K><G><Y><N><K><E><L><R><P><V><A><H><K><E><E><S><V><D><V><A><L><A><L><T><L><S><N><L><I><S><L><K><E><V><E><E><T><L><T><T><N><V><W><I><E><H><G><W><T><D><N><R><L><K><W><N><A><E><E><F><G><N><I><S><V><L><R><L><P><P><D><M><V><W><L><P><E><I><V><L><E><N><N><N><D><G><S><F><Q><I><S><Y><S><C><N><V><L><V><Y><H><Y><G><F><V><Y><W><L><P><P><A><I><F><R><S><S><C><P><I><S><V><T><Y><F><P><F><D><W><Q><N><C><S><L><K><F><S><S><L><K><Y><T><A><K><E><I><T><L><S><L><K><Q><D><A><K><E><N><R><T><Y><P><V><E><W><I><I><I><D><P><E><G><F><T><E><N><G><E><W><E><I><V><H><R><P><A><R><V><N><V><D><P><R><A><P><L><D><S><P><S><R><Q><D><I><T><F><Y><L><I><I><R><R><K><P><L><F><Y><I><I><N><I><L><V><P><C><V><L><I><S><F><M><V><N><L><V><F><Y><L><P><A><D><S><G><E><K><T><S><V><A><I><S><V><L><L><A><Q><S><V><F><L><L><L><I><S><K><R><L><P><A><T><S><M><A><I><P><L><I><G><K><F><L><L><F><G><M><V><L><V><T><M><V><V><V><I><C><V><I><V><L><N><I><H><F><R><T><P><S><T><H><V><L><S><E><G><V><K><K><L><F><L><E><T><L><P><E><L><L><H><M><S><R><P><A><E><D><G><P><S><P><G><A><L><V><R><R><S><S><S><L><G><Y><I><S><K><A><E><E><Y><F><L><L><K><S><R><S><D><L><M><F><E><K><Q><S><E><R><H><G><L><A><R><R><L><T><T><A><R><R><P><P><A><S><S><E><Q><A><Q><Q><E><L><F><N><E><L><K><P><A><V><D><G><A><N><F><I><V><N><H><M><R><D><Q><N><N><Y><N><E><E><K><D><S><W><N><R><V><A><R><T><V><D><R><L><C><L><F><V><V><T><P><V><M><V><V><G><T><A><W><I><F><L><Q><G><V><Y><N><Q><P><P><P><Q><P><F><P><G><D><P><Y><S><Y><N><V><Q><D><K><R><F><I>
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP>
Q07001
Q9BZW5
TM6S1_HUMAN
Transmembrane 6 superfamily member 1
Homo
<M><S><A><S><A><A><T><G><V><F><V><L><S><L><S><A><I><P><V><T><Y><V><F><N><H><L><A><A><Q><H><D><S><W><T><I><V><G><V><A><A><L><I><L><F><L><V><A><L><L><A><R><V><L><V><K><R><K><P><P><R><D><P><L><F><Y><V><Y><A><V><F><G><F><T><S><V><V><N><L><I><I><G><L><E><Q><D><G><I><I><D><G><F><M><T><H><Y><L><R><E><G><E><P><Y><L><N><T><A><Y><G><H><M><I><C><Y><W><D><G><S><A><H><Y><L><M><Y><L><V><M><V><A><A><I><A><W><E><E><T><Y><R><T><I><G><L><Y><W><V><G><S><I><I><M><S><V><V><V><F><V><P><G><N><I><V><G><K><Y><G><T><R><I><C><P><A><F><F><L><S><I><P><Y><T><C><L><P><V><W><A><G><F><R><I><Y><N><Q><P><S><E><N><Y><N><Y><P><S><K><V><I><Q><E><A><Q><A><K><D><L><L><R><R><P><F><D><L><M><L><V><V><C><L><L><L><A><T><G><F><C><L><F><R><G><L><I><A><L><D><C><P><S><E><L><C><R><L><Y><T><Q><F><Q><E><P><Y><L><K><D><P><A><A><Y><P><K><I><Q><M><L><A><Y><M><F><Y><S><V><P><Y><F><V><T><A><L><Y><G><L><V><V><P><G><C><S><W><M><P><D><I><T><L><I><H><A><G><G><L><A><Q><A><Q><F><S><H><I><G><A><S><L><H><A><R><T><A><Y><V><Y><R><V><P><E><E><A><K><I><L><F><L><A><L><N><I><A><Y><G><V><L><P><Q><L><L><A><Y><R><C><I><Y><K><P><E><F><F><I><K><T><K><A><E><E><K><V><E>
May function as sterol isomerase.<BOP>
Q9BZW5
Q86UD7
TBC26_HUMAN
TBC1 domain family member 26
Homo
<M><E><M><D><G><D><P><Y><N><L><P><A><Q><G><Q><G><N><I><I><I><T><K><Y><E><Q><G><H><R><A><G><A><A><V><D><L><G><H><E><Q><V><D><V><R><K><Y><T><N><N><L><G><I><V><H><E><M><E><L><P><H><V><S><A><L><E><V><K><Q><R><R><K><E><S><K><R><T><N><K><W><Q><K><M><L><A><D><W><T><K><Y><R><S><T><K><K><L><S><Q><R><V><Y><K><V><I><P><L><A><V><R><G><R><A><W><S><L><L><L><D><I><D><R><I><K><S><Q><N><P><G><K><Y><K><V><M><K><E><K><G><K><R><S><S><R><I><I><H><C><I><Q><L><D><V><S><H><T><L><Q><K><H><M><M><F><I><Q><R><F><G><V><K><Q><Q><E><L><C><D><I><L><V><A><Y><S><A><Y><N><P><E><V><G><Y><H><R><D><L><S><R><I><T><A><I><L><L><L><C><L><P><E><E><D><A><F><W><A><L><T><Q><L><L><A><G><E><R><H><S><L><W><Y><S><T><A><Q><I><L><P><G><S><R><G><S><Y><R><T><R><S><R><C><C><T><S><P><S><Q><R><S>
May act as a GTPase-activating protein for Rab family protein(s).<BOP>
Q86UD7
Q2I0M5
RSPO4_HUMAN
Roof plate-specific spondin-4
Homo
<M><R><A><P><L><C><L><L><L><L><V><A><H><A><V><D><M><L><A><L><N><R><R><K><K><Q><V><G><T><G><L><G><G><N><C><T><G><C><I><I><C><S><E><E><N><G><C><S><T><C><Q><Q><R><L><F><L><F><I><R><R><E><G><I><R><Q><Y><G><K><C><L><H><D><C><P><P><G><Y><F><G><I><R><G><Q><E><V><N><R><C><K><K><C><G><A><T><C><E><S><C><F><S><Q><D><F><C><I><R><C><K><R><Q><F><Y><L><Y><K><G><K><C><L><P><T><C><P><P><G><T><L><A><H><Q><N><T><R><E><C><Q><G><E><C><E><L><G><P><W><G><G><W><S><P><C><T><H><N><G><K><T><C><G><S><A><W><G><L><E><S><R><V><R><E><A><G><R><A><G><H><E><E><A><A><T><C><Q><V><L><S><E><S><R><K><C><P><I><Q><R><P><C><P><G><E><R><S><P><G><Q><K><K><G><R><K><D><R><R><P><R><K><D><R><K><L><D><R><R><L><D><V><R><P><R><Q><P><G><L><Q><P>
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway .<BOP>
Q2I0M5
P20618
PSB1_HUMAN
Proteasome gamma chain
Homo
<M><L><S><S><T><A><M><Y><S><A><P><G><R><D><L><G><M><E><P><H><R><A><A><G><P><L><Q><L><R><F><S><P><Y><V><F><N><G><G><T><I><L><A><I><A><G><E><D><F><A><I><V><A><S><D><T><R><L><S><E><G><F><S><I><H><T><R><D><S><P><K><C><Y><K><L><T><D><K><T><V><I><G><C><S><G><F><H><G><D><C><L><T><L><T><K><I><I><E><A><R><L><K><M><Y><K><H><S><N><N><K><A><M><T><T><G><A><I><A><A><M><L><S><T><I><L><Y><S><R><R><F><F><P><Y><Y><V><Y><N><I><I><G><G><L><D><E><E><G><K><G><A><V><Y><S><F><D><P><V><G><S><Y><Q><R><D><S><F><K><A><G><G><S><A><S><A><M><L><Q><P><L><L><D><N><Q><V><G><F><K><N><M><Q><N><V><E><H><V><P><L><S><L><D><R><A><M><R><L><V><K><D><V><F><I><S><A><A><E><R><D><V><Y><T><G><D><A><L><R><I><C><I><V><T><K><E><G><I><R><E><E><T><V><S><L><R><K><D>
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).<BOP>
P20618
P37023
ACVL1_HUMAN
TGF-B superfamily receptor type I
Homo
<M><T><L><G><S><P><R><K><G><L><L><M><L><L><M><A><L><V><T><Q><G><D><P><V><K><P><S><R><G><P><L><V><T><C><T><C><E><S><P><H><C><K><G><P><T><C><R><G><A><W><C><T><V><V><L><V><R><E><E><G><R><H><P><Q><E><H><R><G><C><G><N><L><H><R><E><L><C><R><G><R><P><T><E><F><V><N><H><Y><C><C><D><S><H><L><C><N><H><N><V><S><L><V><L><E><A><T><Q><P><P><S><E><Q><P><G><T><D><G><Q><L><A><L><I><L><G><P><V><L><A><L><L><A><L><V><A><L><G><V><L><G><L><W><H><V><R><R><R><Q><E><K><Q><R><G><L><H><S><E><L><G><E><S><S><L><I><L><K><A><S><E><Q><G><D><S><M><L><G><D><L><L><D><S><D><C><T><T><G><S><G><S><G><L><P><F><L><V><Q><R><T><V><A><R><Q><V><A><L><V><E><C><V><G><K><G><R><Y><G><E><V><W><R><G><L><W><H><G><E><S><V><A><V><K><I><F><S><S><R><D><E><Q><S><W><F><R><E><T><E><I><Y><N><T><V><L><L><R><H><D><N><I><L><G><F><I><A><S><D><M><T><S><R><N><S><S><T><Q><L><W><L><I><T><H><Y><H><E><H><G><S><L><Y><D><F><L><Q><R><Q><T><L><E><P><H><L><A><L><R><L><A><V><S><A><A><C><G><L><A><H><L><H><V><E><I><F><G><T><Q><G><K><P><A><I><A><H><R><D><F><K><S><R><N><V><L><V><K><S><N><L><Q><C><C><I><A><D><L><G><L><A><V><M><H><S><Q><G><S><D><Y><L><D><I><G><N><N><P><R><V><G><T><K><R><Y><M><A><P><E><V><L><D><E><Q><I><R><T><D><C><F><E><S><Y><K><W><T><D><I><W><A><F><G><L><V><L><W><E><I><A><R><R><T><I><V><N><G><I><V><E><D><Y><R><P><P><F><Y><D><V><V><P><N><D><P><S><F><E><D><M><K><K><V><V><C><V><D><Q><Q><T><P><T><I><P><N><R><L><A><A><D><P><V><L><S><G><L><A><Q><M><M><R><E><C><W><Y><P><N><P><S><A><R><L><T><A><L><R><I><K><K><T><L><Q><K><I><S><N><S><P><E><K><P><K><V><I><Q>
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.<BOP>
P37023
Q96NG3
ODAD4_HUMAN
Tetratricopeptide repeat protein 25
Homo
<M><S><D><P><E><G><E><T><L><R><S><T><F><P><S><Y><M><A><E><G><E><R><L><Y><L><C><G><E><F><S><K><A><A><Q><S><F><S><N><A><L><Y><L><Q><D><G><D><K><N><C><L><V><A><R><S><K><C><F><L><K><M><G><D><L><E><R><S><L><K><D><A><E><A><S><L><Q><S><D><P><A><F><C><K><G><I><L><Q><K><A><E><T><L><Y><T><M><G><D><F><E><F><A><L><V><F><Y><H><R><G><Y><K><L><R><P><D><R><E><F><R><V><G><I><Q><K><A><Q><E><A><I><N><N><S><V><G><S><P><S><S><I><K><L><E><N><K><G><D><L><S><F><L><S><K><Q><A><E><N><I><K><A><Q><Q><K><P><Q><P><M><K><H><L><L><H><P><T><K><G><E><P><K><W><K><A><S><L><K><S><E><K><T><V><R><Q><L><L><G><E><L><Y><V><D><K><E><Y><L><E><K><L><L><L><D><E><D><L><I><K><G><T><M><K><G><G><L><T><V><E><D><L><I><M><T><G><I><N><Y><L><D><T><H><S><N><F><W><R><Q><Q><K><P><I><Y><A><R><E><R><D><R><K><L><M><Q><E><K><W><L><R><D><H><K><R><R><P><S><Q><T><A><H><Y><I><L><K><S><L><E><D><I><D><M><L><L><T><S><G><S><A><E><G><S><L><Q><K><A><E><K><V><L><K><K><V><L><E><W><N><K><E><E><V><P><N><K><D><E><L><V><G><N><L><Y><S><C><I><G><N><A><Q><I><E><L><G><Q><M><E><A><A><L><Q><S><H><R><K><D><L><E><I><A><K><E><Y><D><L><P><D><A><K><S><R><A><L><D><N><I><G><R><V><F><A><R><V><G><K><F><Q><Q><A><I><D><T><W><E><E><K><I><P><L><A><K><T><T><L><E><K><T><W><L><F><H><E><I><G><R><C><Y><L><E><L><D><Q><A><W><Q><A><Q><N><Y><G><E><K><S><Q><Q><C><A><E><E><E><G><D><I><E><W><Q><L><N><A><S><V><L><V><A><Q><A><Q><V><K><L><R><D><F><E><S><A><V><N><N><F><E><K><A><L><E><R><A><K><L><V><H><N><N><E><A><Q><Q><A><I><I><S><A><L><D><D><A><N><K><G><I><I><R><E><L><R><K><T><N><Y><V><E><N><L><K><E><K><S><E><G><E><A><S><L><Y><E><D><R><I><I><T><R><E><K><D><M><R><R><V><R><D><E><P><E><K><V><V><K><Q><W><D><H><S><E><D><E><K><E><T><D><E><D><D><E><A><F><G><E><A><L><Q><S><P><A><S><G><K><Q><S><V><E><A><G><K><A><R><S><D><L><G><A><V><A><K><G><L><S><G><E><L><G><T><R><S><G><E><T><G><R><K><L><L><E><A><G><R><R><E><S><R><E><I><Y><R><R><P><S><G><E><L><E><Q><R><L><S><G><E><F><S><R><Q><E><P><E><E><L><K><K><L><S><E><V><G><R><R><E><P><E><E><L><G><K><T><Q><F><G><E><I><G><E><T><K><K><T><G><N><E><M><E><K><E><Y><E>
Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme.<BOP>
Q96NG3
P04216
THY1_HUMAN
Thy-1 antigen
Homo
<M><N><L><A><I><S><I><A><L><L><L><T><V><L><Q><V><S><R><G><Q><K><V><T><S><L><T><A><C><L><V><D><Q><S><L><R><L><D><C><R><H><E><N><T><S><S><S><P><I><Q><Y><E><F><S><L><T><R><E><T><K><K><H><V><L><F><G><T><V><G><V><P><E><H><T><Y><R><S><R><T><N><F><T><S><K><Y><N><M><K><V><L><Y><L><S><A><F><T><S><K><D><E><G><T><Y><T><C><A><L><H><H><S><G><H><S><P><P><I><S><S><Q><N><V><T><V><L><R><D><K><L><V><K><C><E><G><I><S><L><L><A><Q><N><T><S><W><L><L><L><L><L><L><S><L><S><L><L><Q><A><T><D><F><M><S><L>
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.<BOP>
P04216
Q9Y2H8
ZN510_HUMAN
Zinc finger protein 510
Homo
<M><S><P><H><P><E><A><I><T><D><C><V><T><L><N><T><V><G><Q><L><A><E><G><G><Y><P><L><R><F><S><T><L><F><Q><E><Q><Q><K><M><N><I><S><Q><A><S><V><S><F><K><D><V><T><I><E><F><T><Q><E><E><W><Q><Q><M><A><P><V><Q><K><N><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><V><G><Y><C><C><F><K><P><E><V><I><F><K><L><E><Q><G><E><E><P><W><F><S><E><E><E><F><S><N><Q><S><H><P><K><D><Y><R><G><D><D><L><I><K><Q><N><K><K><I><K><D><K><H><L><E><Q><A><I><C><I><N><N><K><T><L><T><T><E><E><E><K><V><L><G><K><P><F><T><L><H><V><A><A><V><A><S><T><K><M><S><C><K><C><N><S><W><E><V><N><L><Q><S><I><S><E><F><I><I><N><N><R><N><Y><S><T><K><K><I><G><C><G><N><V><C><E><N><S><P><F><K><I><N><F><E><K><T><Q><T><G><E><K><F><Y><E><H><N><K><N><M><K><A><L><N><Y><N><E><N><L><P><K><H><P><K><F><Q><T><L><E><Q><A><F><E><C><N><K><I><G><K><A><F><N><D><K><A><N><C><V><K><H><N><S><S><H><T><G><E><T><S><S><K><D><D><E><F><R><K><N><C><D><K><K><T><L><F><D><H><R><R><T><G><T><G><K><K><H><L><H><L><N><Q><C><G><K><S><F><E><K><S><T><V><E><E><Y><N><K><L><N><M><G><I><K><H><Y><E><L><N><P><S><G><N><N><F><N><R><K><A><H><L><T><D><P><Q><T><A><V><I><E><E><N><P><L><V><S><N><D><R><T><Q><T><W><V><K><S><S><E><Y><H><E><N><K><K><S><Y><Q><T><S><V><H><R><V><R><R><R><S><H><S><M><M><K><P><Y><K><C><N><E><C><G><K><S><F><C><Q><K><G><H><L><I><Q><H><Q><R><T><H><T><G><E><K><P><F><E><C><S><E><C><G><K><T><F><S><Q><K><S><H><L><S><T><H><Q><R><I><H><T><A><E><K><P><Y><K><C><N><E><C><G><K><T><F><V><Q><K><S><T><L><R><G><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><V><Q><K><S><T><L><R><D><H><H><R><I><H><T><G><E><K><S><F><Q><C><N><Q><C><G><K><T><F><G><Q><K><S><N><L><R><I><H><Q><R><T><H><T><G><E><K><T><Y><Q><C><N><E><C><E><K><S><F><W><R><K><D><H><L><I><Q><H><Q><K><T><H><T><G><E><K><P><F><K><C><N><E><C><G><K><T><F><A><R><T><S><T><L><R><V><H><Q><R><I><H><T><G><E><K><P><F><K><C><N><E><C><G><K><K><F><V><R><K><A><I><L><S><D><H><Q><R><I><H><T><G><E><K><P><F><Q><C><N><K><C><G><K><T><F><G><Q><K><S><N><L><R><I><H><Q><R><T><H><S><G><E><K><S><Y><E><C><N><E><Y><G><K><L><C><K><K><S><T><L><S><L><Y><Q><K><I><Q><G><E><G><N><P><Y>
May be involved in transcriptional regulation.<BOP>
Q9Y2H8
A6NNZ2
TBB8B_HUMAN
Tubulin beta 8B
Homo
<M><R><E><I><V><L><T><Q><T><G><Q><C><G><N><Q><I><G><A><K><F><W><E><V><I><S><D><E><H><A><I><D><S><A><G><T><Y><H><G><D><S><H><L><Q><L><E><R><I><N><V><H><H><H><E><A><S><G><G><R><Y><V><P><R><A><V><L><V><D><L><E><P><G><T><M><D><S><V><H><S><G><P><F><G><Q><V><F><R><P><D><N><F><I><S><G><Q><C><G><A><G><N><N><W><A><K><G><R><Y><T><E><G><A><E><L><T><E><S><V><M><D><V><V><R><K><E><A><E><S><C><D><C><L><Q><G><F><Q><L><T><H><S><L><G><G><G><T><G><S><G><M><G><T><L><L><I><S><K><I><R><E><E><Y><P><D><R><I><I><N><T><F><S><I><L><P><S><P><K><V><S><D><T><V><V><E><P><Y><N><A><T><L><S><V><H><Q><L><I><E><N><A><D><E><T><F><C><I><D><N><E><A><L><Y><D><I><C><S><R><T><L><K><L><P><T><P><T><Y><G><D><L><N><H><L><V><S><A><T><M><S><G><V><T><T><C><L><R><F><P><G><Q><L><N><A><D><L><R><K><L><A><V><N><M><V><P><F><P><R><L><H><F><F><M><P><G><F><A><P><L><T><S><R><G><S><Q><Q><Y><R><A><L><T><V><A><E><L><T><Q><Q><M><F><D><A><K><N><M><M><A><A><C><D><P><R><H><G><C><Y><L><T><V><A><A><I><F><R><G><R><M><P><M><R><E><V><D><E><Q><M><F><N><I><Q><D><K><N><S><S><Y><F><A><D><W><F><P><D><N><V><K><T><A><V><C><D><I><P><P><R><G><L><K><M><S><A><T><F><I><G><N><N><A><A><I><Q><E><L><F><T><C><V><S><E><Q><F><T><A><M><F><R><R><K><A><F><L><H><W><Y><T><G><E><G><M><D><E><M><E><F><T><E><A><E><S><N><M><N><D><L><V><S><E><Y><Q><Q><Y><Q><D><A><T><A><E><E><E><E><D><E><E><Y><A><E><E><E><V><A>
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.<BOP>
A6NNZ2
Q70YC4
TALAN_HUMAN
Talanin
Homo
<M><S><A><L><G><Q><I><T><I><T><V><S><R><C><W><N><T><E><R><N><Q><T><D><K><N><P><C><L><H><G><A><Y><L><Q><L><R><E><T><V><K><N><K><S><T><H><L><K><K><P><L><M><K><Q><A><P><P><W><K><D><H><L><T><F><Q><P><L><H><P><A><E><R><K><T><Q><V><W><R><W><Q><S><G><N><S><S><D><L><E><T><T><S><S><A><S><P><W><P><T><G><S><N><R><D><V><V><L><N><T><L><A><E><S><C><C><G><L><S><E><L><I><T><A><P><P><Y><A><G><V><S><I><Q><G><F><S><Q><I><W><V><L><F><P><F><C><G><G><T><F><H><H><N><E><K><D><V><L><G><L><Q><D><F><E><R><E><S><V><S><T><S><Q><S><R><N><I><S><L><L><T><L><G><Q><L><Q><N><C><V><I><G><K><L><T><I><I><D><L><L><T><E><H><L><L><G><V><R><H><G><V><I><C><F><P><W><G><L><P><S><S><S>
May play a role in uric acid excretion.<BOP>
Q70YC4
Q9NUX5
POTE1_HUMAN
POT1-like telomere end-binding protein
Homo
<M><S><L><V><P><A><T><N><Y><I><Y><T><P><L><N><Q><L><K><G><G><T><I><V><N><V><Y><G><V><V><K><F><F><K><P><P><Y><L><S><K><G><T><D><Y><C><S><V><V><T><I><V><D><Q><T><N><V><K><L><T><C><L><L><F><S><G><N><Y><E><A><L><P><I><I><Y><K><N><G><D><I><V><R><F><H><R><L><K><I><Q><V><Y><K><K><E><T><Q><G><I><T><S><S><G><F><A><S><L><T><F><E><G><T><L><G><A><P><I><I><P><R><T><S><S><K><Y><F><N><F><T><T><E><D><H><K><M><V><E><A><L><R><V><W><A><S><T><H><M><S><P><S><W><T><L><L><K><L><C><D><V><Q><P><M><Q><Y><F><D><L><T><C><Q><L><L><G><K><A><E><V><D><G><A><S><F><L><L><K><V><W><D><G><T><R><T><P><F><P><S><W><R><V><L><I><Q><D><L><V><L><E><G><D><L><S><H><I><H><R><L><Q><N><L><T><I><D><I><L><V><Y><D><N><H><V><H><V><A><R><S><L><K><V><G><S><F><L><R><I><Y><S><L><H><T><K><L><Q><S><M><N><S><E><N><Q><T><M><L><S><L><E><F><H><L><H><G><G><T><S><Y><G><R><G><I><R><V><L><P><E><S><N><S><D><V><D><Q><L><K><K><D><L><E><S><A><N><L><T><A><N><Q><H><S><D><V><I><C><Q><S><E><P><D><D><S><F><P><S><S><G><S><V><S><L><Y><E><V><E><R><C><Q><Q><L><S><A><T><I><L><T><D><H><Q><Y><L><E><R><T><P><L><C><A><I><L><K><Q><K><A><P><Q><Q><Y><R><I><R><A><K><L><R><S><Y><K><P><R><R><L><F><Q><S><V><K><L><H><C><P><K><C><H><L><L><Q><E><V><P><H><E><G><D><L><D><I><I><F><Q><D><G><A><T><K><T><P><D><V><K><L><Q><N><T><S><L><Y><D><S><K><I><W><T><T><K><N><Q><K><G><R><K><V><A><V><H><F><V><K><N><N><G><I><L><P><L><S><N><E><C><L><L><L><I><E><G><G><T><L><S><E><I><C><K><L><S><N><K><F><N><S><V><I><P><V><R><S><G><H><E><D><L><E><L><L><D><L><S><A><P><F><L><I><Q><G><T><I><H><H><Y><G><C><K><Q><C><S><S><L><R><S><I><Q><N><L><N><S><L><V><D><K><T><S><W><I><P><S><S><V><A><E><A><L><G><I><V><P><L><Q><Y><V><F><V><M><T><F><T><L><D><D><G><T><G><V><L><E><A><Y><L><M><D><S><D><K><F><F><Q><I><P><A><S><E><V><L><M><D><D><D><L><Q><K><S><V><D><M><I><M><D><M><F><C><P><P><G><I><K><I><D><A><Y><P><W><L><E><C><F><I><K><S><Y><N><V><T><N><G><T><D><N><Q><I><C><Y><Q><I><F><D><T><T><V><A><E><D><V><I>
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of
Q9NUX5
Q15270
NKX11_HUMAN
NKX-1.1
Homo
<M><S><A><S><G><P><E><A><P><G><D><I><P><A><L><P><P><P><P><Q><P><G><S><G><P><A><P><P><A><P><A><A><A><A><Q><E><A><M><D><G><R><A><E><L><P><A><F><P><R><A><G><A><P><P><L><A><A><S><D><T><V><P><A><A><P><E><G><A><G><A><A><R><P><A><A><P><L><R><P><T><S><F><S><V><L><D><I><L><D><P><N><K><F><N><S><R><R><R><R><C><V><L><L><G><P><V><A><P><A><A><C><A><P><C><A><S><A><P><C><A><P><A><P><A><A><S><G><R><P><P><R><A><E><E><L><E><R><R><A><L><A><G><A><G><G><V><G><A><A><G><A><E><P><P><N><A><G><D><P><F><K><A><G><E><A><E><T><N><D><T><N><G><Y><S><S><G><G><G><G><H><S><P><S><A><D><S><G><D><E><V><P><D><D><E><D><D><D><E><D><E><A><P><E><T><E><A><A><R><G><A><E><E><A><R><G><G><G><G><G><L><G><A><R><G><S><G><C><Q><G><A><A><E><T><D><A><S><P><G><A><T><V><D><E><A><A><A><P><G><P><R><E><N><S><P><V><A><Q><G><P><P><G><G><A><A><A><P><G><G><A><G><T><T><P><Q><G><T><A><T><A><A><K><P><K><R><K><R><T><G><S><D><S><K><S><G><K><P><R><R><A><R><T><A><F><T><Y><E><Q><L><V><A><L><E><N><K><F><K><A><T><R><Y><L><S><V><C><E><R><L><N><L><A><L><S><L><S><L><T><E><T><Q><V><K><I><W><F><Q><N><R><R><T><K><W><K><K><Q><N><P><G><A><D><T><S><A><P><T><G><G><G><G><G><P><G><P><G><A><G><P><G><T><G><L><P><G><G><L><S><P><L><S><P><S><P><P><M><G><A><P><L><G><M><H><G><P><A><G><Y><P><A><H><G><P><G><G><L><V><C><A><A><Q><L><P><F><L><S><S><P><A><V><L><S><P><F><V><L><G><S><Q><T><Y><G><A><P><A><F><Y><A><P><H><L>
May be required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly by regulating the transcription of specific factors involved in energy balance.<BOP>
Q15270
Q9UBF9
MYOTI_HUMAN
Titin immunoglobulin domain protein
Homo
<M><F><N><Y><E><R><P><K><H><F><I><Q><S><Q><N><P><C><G><S><R><L><Q><P><P><G><P><E><T><S><S><F><S><S><Q><T><K><Q><S><S><I><I><I><Q><P><R><Q><C><T><E><Q><R><F><S><A><S><S><T><L><S><S><H><I><T><M><S><S><S><A><F><P><A><S><P><K><Q><H><A><G><S><N><P><G><Q><R><V><T><T><T><Y><N><Q><S><P><A><S><F><L><S><S><I><L><P><S><Q><P><D><Y><N><S><S><K><I><P><S><A><M><D><S><N><Y><Q><Q><S><S><A><G><Q><P><I><N><A><K><P><S><Q><T><A><N><A><K><P><I><P><R><T><P><D><H><E><I><Q><G><S><K><E><A><L><I><Q><D><L><E><R><K><L><K><C><K><D><T><L><L><H><N><G><N><Q><R><L><T><Y><E><E><K><M><A><R><R><L><L><G><P><Q><N><A><A><A><V><F><Q><A><Q><D><D><S><G><A><Q><D><S><Q><Q><H><N><S><E><H><A><R><L><Q><V><P><T><S><Q><V><R><S><R><S><T><S><R><G><D><V><N><D><Q><D><A><I><Q><E><K><F><Y><P><P><R><F><I><Q><V><P><E><N><M><S><I><D><E><G><R><F><C><R><M><D><F><K><V><S><G><L><P><A><P><D><V><S><W><Y><L><N><G><R><T><V><Q><S><D><D><L><H><K><M><I><V><S><E><K><G><L><H><S><L><I><F><E><V><V><R><A><S><D><A><G><A><Y><A><C><V><A><K><N><R><A><G><E><A><T><F><T><V><Q><L><D><V><L><A><K><E><H><K><R><A><P><M><F><I><Y><K><P><Q><S><K><K><V><L><E><G><D><S><V><K><L><E><C><Q><I><S><A><I><P><P><P><K><L><F><W><K><R><N><N><E><M><V><Q><F><N><T><D><R><I><S><L><Y><Q><D><N><T><G><R><V><T><L><L><I><K><D><V><N><K><K><D><A><G><W><Y><T><V><S><A><V><N><E><A><G><V><T><T><C><N><T><R><L><D><V><T><A><R><P><N><Q><T><L><P><A><P><K><Q><L><R><V><R><P><T><F><S><K><Y><L><A><L><N><G><K><G><L><N><V><K><Q><A><F><N><P><E><G><E><F><Q><R><L><A><A><Q><S><G><L><Y><E><S><E><E><L>
Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.<BOP>
Q9UBF9
P16104
H2AX_HUMAN
Histone H2A.X
Homo
<M><S><G><R><G><K><T><G><G><K><A><R><A><K><A><K><S><R><S><S><R><A><G><L><Q><F><P><V><G><R><V><H><R><L><L><R><K><G><H><Y><A><E><R><V><G><A><G><A><P><V><Y><L><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><G><V><T><I><A><Q><G><G><V><L><P><N><I><Q><A><V><L><L><P><K><K><T><S><A><T><V><G><P><K><A><P><S><G><G><K><K><A><T><Q><A><S><Q><E><Y>
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.<BOP>
P16104
Q86WN1
FCSD1_HUMAN
Protein nervous wreck 2
Homo
<M><Q><P><P><P><R><K><V><K><P><A><Q><E><V><K><L><R><F><L><E><Q><L><S><I><L><Q><T><W><Q><Q><R><E><A><D><L><L><E><D><I><R><S><Y><S><K><Q><R><A><A><I><E><R><E><Y><G><Q><A><L><Q><K><L><A><G><P><F><L><K><R><E><G><H><R><S><G><E><M><D><S><R><G><R><T><V><F><G><A><W><R><C><L><L><D><A><T><V><A><G><G><Q><T><R><L><Q><A><S><D><R><Y><R><D><L><A><G><G><T><G><R><S><A><K><E><Q><V><L><R><K><G><T><E><N><L><Q><R><A><Q><A><E><V><L><Q><S><V><R><E><L><S><R><S><R><K><L><Y><G><Q><R><E><R><V><W><A><L><A><Q><E><K><A><A><D><V><Q><A><R><L><N><R><S><D><H><G><I><F><H><S><R><T><S><L><Q><K><L><S><T><K><L><S><A><Q><S><A><Q><Y><S><Q><Q><L><Q><A><A><R><N><E><Y><L><L><N><L><V><A><T><N><A><H><L><D><H><Y><Y><Q><E><E><L><P><A><L><L><K><A><L><V><S><E><L><S><E><H><L><R><D><P><L><T><S><L><S><H><T><E><L><E><A><A><E><V><I><L><E><H><A><H><R><G><E><Q><T><T><S><Q><V><S><W><E><Q><D><L><K><L><F><L><Q><E><P><G><V><F><S><P><T><P><P><Q><Q><F><Q><P><A><G><T><D><Q><V><C><V><L><E><W><G><A><E><G><V><A><G><K><S><G><L><E><K><E><V><Q><R><L><T><S><R><A><A><R><D><Y><K><I><Q><N><H><G><H><R><V><L><Q><R><L><E><Q><R><R><Q><Q><A><S><E><R><E><A><P><S><I><E><Q><R><L><Q><E><V><R><E><S><I><R><R><A><Q><V><S><Q><V><K><G><A><A><R><L><A><L><L><Q><G><A><G><L><D><V><E><R><W><L><K><P><A><M><T><Q><A><Q><D><E><V><E><Q><E><R><R><L><S><E><A><R><L><S><Q><R><D><L><S><P><T><A><E><D><A><E><L><S><D><F><E><E><C><E><E><T><G><E><L><F><E><E><P><A><P><Q><A><L><A><T><R><A><L><P><C><P><A><H><V><V><F><R><Y><Q><A><G><R><E><D><E><L><T><I><T><E><G><E><W><L><E><V><I><E><E><G><D><A><D><E><W><V><K><A><R><N><Q><H><G><E><V><G><F><V><P><E><R><Y><L><N><F><P><D><L><S><L><P><E><S><S><Q><D><S><D><N><P><C><G><A><E><P><T><A><F><L><A><Q><A><L><Y><S><Y><T><G><Q><S><A><E><E><L><S><F><P><E><G><A><L><I><R><L><L><P><R><A><Q><D><G><V><D><D><G><F><W><R><G><E><F><G><G><R><V><G><V><F><P><S><L><L><V><E><E><L><L><G><P><P><G><P><P><E><L><S><D><P><E><Q><M><L><P><S><P><S><P><P><S><F><S><P><P><A><P><T><S><V><L><D><G><P><P><A><P><V><L><P><G><D><K><A><L><D><F><P><G><F><L><D><M><M><A><P><R><L><R><P><M><R><P><P><P><P><P><P><A><K><A><P><D><P><G><H><P><D><P><L><T>
Promotes actin polymerization mediated by SNX9 and WASL.<BOP>
Q86WN1
Q9P209
CEP72_HUMAN
Centrosomal protein of 72 kDa
Homo
<M><A><R><A><G><P><R><L><V><L><S><E><E><A><V><R><A><K><S><G><L><G><P><H><R><D><L><A><E><L><Q><S><L><S><I><P><G><T><Y><Q><E><K><I><T><H><L><G><H><S><L><M><S><L><T><G><L><K><S><L><D><L><S><R><N><S><L><V><S><L><E><G><I><Q><Y><L><T><A><L><E><S><L><N><L><Y><Y><N><C><I><S><S><L><A><E><V><F><R><L><H><A><L><T><E><L><V><D><V><D><F><R><L><N><P><V><V><K><V><E><P><D><Y><R><L><F><V><V><H><L><L><P><K><L><Q><Q><L><D><D><R><P><V><R><A><S><E><R><K><A><S><R><L><H><F><A><S><E><D><S><L><D><S><K><E><S><V><P><A><S><L><K><E><G><R><P><H><H><P><R><A><K><C><T><E><A><L><A><K><Q><S><L><V><M><D><A><D><D><E><A><V><L><N><L><I><A><E><C><E><W><D><L><G><R><P><P><G><S><T><S><F><S><Q><K><G><R><E><A><D><S><R><G><S><Q><E><S><R><H><L><L><S><P><Q><L><V><Q><Y><Q><C><G><D><S><G><K><Q><G><R><E><T><R><R><S><S><C><R><G><C><C><L><E><K><M><P><W><S><Q><L><C><G><E><L><P><P><L><Y><G><A><E><P><E><A><S><R><A><P><R><P><H><T><Y><F><T><P><H><P><D><S><M><D><T><E><D><S><A><S><S><Q><K><L><D><L><S><G><E><M><V><P><G><P><L><P><A><P><G><K><C><R><K><R><R><M><P><V><G><R><F><Q><T><F><S><D><Q><E><G><L><G><C><P><E><R><T><H><G><S><S><V><P><K><E><S><L><S><R><Q><D><S><S><E><S><R><N><G><R><T><L><S><Q><P><E><A><S><E><T><E><E><Q><R><S><R><G><V><T><D><T><R><E><P><S><P><G><S><H><S><A><L><P><G><K><K><T><A><L><Q><A><A><L><L><E><T><L><L><D><L><V><D><R><S><W><G><G><C><R><S><L><H><S><N><E><A><F><L><A><Q><A><R><H><I><L><S><S><V><E><E><F><T><A><A><Q><D><S><S><A><M><V><G><E><D><V><G><S><L><A><L><E><S><K><S><L><Q><S><R><L><A><E><Q><Q><Q><Q><H><A><R><E><M><S><E><V><T><A><E><L><H><H><T><H><K><E><L><D><D><L><R><Q><H><L><D><K><S><L><E><E><N><S><R><L><K><S><L><L><L><S><M><K><K><E><V><K><S><A><D><T><A><A><T><L><N><L><Q><I><A><G><L><Q><T><S><V><K><R><L><C><G><E><I><V><E><L><K><Q><H><L><E><H><Y><D><K><I><Q><E><L><T><Q><M><L><Q><E><S><H><S><S><L><V><S><T><N><E><H><L><L><Q><E><L><S><Q><V><R><A><Q><H><R><A><E><V><E><Q><M><H><W><S><Y><Q><E><L><K><K><T><M><A><L><F><P><H><S><S><A><S><H><G><G><C><Q><A><C>
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) . Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 .<BOP>
Q9P209
Q969W0
SPTSA_HUMAN
Small subunit of serine palmitoyltransferase A
Homo
<M><A><G><M><A><L><A><R><A><W><K><Q><M><S><W><F><Y><Y><Q><Y><L><L><V><T><A><L><Y><M><L><E><P><W><E><R><T><V><F><N><S><M><L><V><S><I><V><G><M><A><L><Y><T><G><Y><V><F><M><P><Q><H><I><M><A><I><L><H><Y><F><E><I><V><Q>
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA . Plays a role in MBOAT7 location to mitochondria-associated membranes (MAMs), may me involved in fatty acid remodeling phosphatidylinositol (PI) .<BOP>
Q969W0
Q9NPI0
TM138_HUMAN
Transmembrane protein 138
Homo
<M><L><Q><T><S><N><Y><S><L><V><L><S><L><Q><F><L><L><L><S><Y><D><L><F><V><N><S><F><S><E><L><L><Q><K><T><P><V><I><Q><L><V><L><F><I><I><Q><D><I><A><V><L><F><N><I><I><I><I><F><L><M><F><F><N><T><F><V><F><Q><A><G><L><V><N><L><L><F><H><K><F><K><G><T><I><I><L><T><A><V><Y><F><A><L><S><I><S><L><H><V><W><V><M><N><L><R><W><K><N><S><N><S><F><I><W><T><D><G><L><Q><M><L><F><V><F><Q><R><L><A><A><V><L><Y><C><Y><F><Y><K><R><T><A><V><R><L><G><D><P><H><F><Y><Q><D><S><L><W><L><R><K><E><F><M><Q><V><R><R>
Required for ciliogenesis.<BOP>
Q9NPI0
Q8TAD2
IL17D_HUMAN
Interleukin-27
Homo
<M><L><V><A><G><F><L><L><A><L><P><P><S><W><A><A><G><A><P><R><A><G><R><R><P><A><R><P><R><G><C><A><D><R><P><E><E><L><L><E><Q><L><Y><G><R><L><A><A><G><V><L><S><A><F><H><H><T><L><Q><L><G><P><R><E><Q><A><R><N><A><S><C><P><A><G><G><R><P><A><D><R><R><F><R><P><P><T><N><L><R><S><V><S><P><W><A><Y><R><I><S><Y><D><P><A><R><Y><P><R><Y><L><P><E><A><Y><C><L><C><R><G><C><L><T><G><L><F><G><E><E><D><V><R><F><R><S><A><P><V><Y><M><P><T><V><V><L><R><R><T><P><A><C><A><G><G><R><S><V><Y><T><E><A><Y><V><T><I><P><V><G><C><T><C><V><P><E><P><E><K><D><A><D><S><I><N><S><S><I><D><K><Q><G><A><K><L><L><L><G><P><N><D><A><P><A><G><P>
Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.<BOP>
Q8TAD2
P0CW23
AKAI1_HUMAN
A-kinase anchor protein inhibitor 1
Homo
<M><V><F><A><P><G><E><K><P><G><N><E><P><E><E><V><K><L><Q><N><A><S><K><Q><I><V><Q><N><A><I><L><Q><A><V><Q><Q><V><S><Q><E><S><Q><R><R><E><E><R><I><S><D><N><R><D><H><I><Q><L><G><V><G><E><L><T><K><K><H><E><K><K>
Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA .<BOP>
P0CW23
Q9H9K5
MER34_HUMAN
Endogenous retroviral envelope protein HEMO, 48 kDa form
Homo
<M><G><S><L><S><N><Y><A><L><L><Q><L><T><L><T><A><F><L><T><I><L><V><Q><P><Q><H><L><L><A><P><V><F><R><T><L><S><I><L><T><N><Q><S><N><C><W><L><C><E><H><L><D><N><A><E><Q><P><E><L><V><F><V><P><A><S><A><S><T><W><W><T><Y><S><G><Q><W><M><Y><E><R><V><W><Y><P><Q><A><E><V><Q><N><H><S><T><S><S><Y><R><K><V><T><W><H><W><E><A><S><M><E><A><Q><G><L><S><F><A><Q><V><R><L><L><E><G><N><F><S><L><C><V><E><N><K><N><G><S><G><P><F><L><G><N><I><P><K><Q><Y><C><N><Q><I><L><W><F><D><S><T><D><G><T><F><M><P><S><I><D><V><T><N><E><S><R><N><D><D><D><D><T><S><V><C><L><G><T><R><Q><C><S><W><F><A><G><C><T><N><R><T><W><N><S><S><A><V><P><L><I><G><L><P><N><T><Q><D><Y><K><W><V><D><R><N><S><G><L><T><W><S><G><N><D><T><C><L><Y><S><C><Q><N><Q><T><K><G><L><L><Y><Q><L><F><R><N><L><F><C><S><Y><G><L><T><E><A><H><G><K><W><R><C><A><D><A><S><I><T><N><D><K><G><H><D><G><H><R><T><P><T><W><W><L><T><G><S><N><L><T><L><S><V><N><N><S><G><L><F><F><L><C><G><N><G><V><Y><K><G><F><P><P><K><W><S><G><R><C><G><L><G><Y><L><V><P><S><L><T><R><Y><L><T><L><N><A><S><Q><I><T><N><L><R><S><F><I><H><K><V><T><P><H><R><C><T><Q><G><D><T><D><N><P><P><L><Y><C><N><P><K><D><N><S><T><I><R><A><L><F><P><S><L><G><T><Y><D><L><E><K><A><I><L><N><I><S><K><A><M><E><Q><E><F><S><A><T><K><Q><T><L><E><A><H><Q><S><K><V><S><S><L><A><S><A><S><R><K><D><H><V><L><D><I><P><T><T><Q><R><Q><T><A><C><G><T><V><G><K><Q><C><C><L><Y><I><N><Y><S><E><E><I><K><S><N><I><Q><R><L><H><E><A><S><E><N><L><K><N><V><P><L><L><D><W><Q><G><I><F><A><K><V><G><D><W><F><R><S><W><G><Y><V><L><L><I><V><L><F><C><L><F><I><F><V><L><I><Y><V><R><V><F><R><K><S><R><R><S><L><N><S><Q><P><L><N><L><A><L><S><P><Q><Q><S><A><Q><L><L><V><S><E><T><S><C><Q><V><S><N><R><A><M><K><G><L><T><T><H><Q><Y><D><T><S><L><L>
Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.<BOP>
Q9H9K5
Q13651
I10R1_HUMAN
Interleukin-10 receptor subunit 1
Homo
<M><L><P><C><L><V><V><L><L><A><A><L><L><S><L><R><L><G><S><D><A><H><G><T><E><L><P><S><P><P><S><V><W><F><E><A><E><F><F><H><H><I><L><H><W><T><P><I><P><N><Q><S><E><S><T><C><Y><E><V><A><L><L><R><Y><G><I><E><S><W><N><S><I><S><N><C><S><Q><T><L><S><Y><D><L><T><A><V><T><L><D><L><Y><H><S><N><G><Y><R><A><R><V><R><A><V><D><G><S><R><H><S><N><W><T><V><T><N><T><R><F><S><V><D><E><V><T><L><T><V><G><S><V><N><L><E><I><H><N><G><F><I><L><G><K><I><Q><L><P><R><P><K><M><A><P><A><N><D><T><Y><E><S><I><F><S><H><F><R><E><Y><E><I><A><I><R><K><V><P><G><N><F><T><F><T><H><K><K><V><K><H><E><N><F><S><L><L><T><S><G><E><V><G><E><F><C><V><Q><V><K><P><S><V><A><S><R><S><N><K><G><M><W><S><K><E><E><C><I><S><L><T><R><Q><Y><F><T><V><T><N><V><I><I><F><F><A><F><V><L><L><L><S><G><A><L><A><Y><C><L><A><L><Q><L><Y><V><R><R><R><K><K><L><P><S><V><L><L><F><K><K><P><S><P><F><I><F><I><S><Q><R><P><S><P><E><T><Q><D><T><I><H><P><L><D><E><E><A><F><L><K><V><S><P><E><L><K><N><L><D><L><H><G><S><T><D><S><G><F><G><S><T><K><P><S><L><Q><T><E><E><P><Q><F><L><L><P><D><P><H><P><Q><A><D><R><T><L><G><N><R><E><P><P><V><L><G><D><S><C><S><S><G><S><S><N><S><T><D><S><G><I><C><L><Q><E><P><S><L><S><P><S><T><G><P><T><W><E><Q><Q><V><G><S><N><S><R><G><Q><D><D><S><G><I><D><L><V><Q><N><S><E><G><R><A><G><D><T><Q><G><G><S><A><L><G><H><H><S><P><P><E><P><E><V><P><G><E><E><D><P><A><A><V><A><F><Q><G><Y><L><R><Q><T><R><C><A><E><E><K><A><T><K><T><G><C><L><E><E><E><S><P><L><T><D><G><L><G><P><K><F><G><R><C><L><V><D><E><A><G><L><H><P><P><A><L><A><K><G><Y><L><K><Q><D><P><L><E><M><T><L><A><S><S><G><A><P><T><G><Q><W><N><Q><P><T><E><E><W><S><L><L><A><L><S><S><C><S><D><L><G><I><S><D><W><S><F><A><H><D><L><A><P><L><G><C><V><A><A><P><G><G><L><L><G><S><F><N><S><D><L><V><T><L><P><L><I><S><S><L><Q><S><S><E>
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well . In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively . These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy .<BOP>
Q13651
P17039
ZNF30_HUMAN
Zinc finger protein KOX28
Homo
<M><A><H><K><Y><V><G><L><Q><Y><H><G><S><V><T><F><E><D><V><A><I><A><F><S><Q><Q><E><W><E><S><L><D><S><S><Q><R><G><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><M><G><H><S><R><S><K><P><H><V><I><A><L><L><E><Q><W><K><E><P><E><V><T><V><R><K><D><G><R><R><W><C><T><D><L><Q><L><E><D><D><T><I><G><C><K><E><M><P><T><S><E><N><C><P><S><F><A><L><H><Q><K><I><S><R><Q><K><P><R><E><C><Q><E><Y><G><K><T><L><C><Q><D><S><K><P><V><Q><H><E><R><I><H><S><S><E><K><P><N><R><C><K><E><C><G><K><N><F><S><N><G><H><Q><L><T><I><H><Q><R><L><H><V><G><E><K><P><Y><K><Y><E><K><C><G><K><A><F><I><S><G><S><A><F><V><K><H><G><R><I><H><T><G><E><K><P><L><K><C><K><Q><C><G><K><T><I><S><G><S><Y><Q><L><T><V><H><K><S><I><H><T><G><K><K><P><Y><E><C><G><E><C><G><K><A><F><L><V><Y><G><K><L><T><R><H><Q><S><T><H><T><G><E><K><P><F><G><C><E><E><C><G><K><A><F><S><T><F><S><Y><L><V><Q><H><Q><R><I><H><T><S><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><T><S><S><P><L><A><K><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><S><F><T><V><Y><G><Q><L><T><R><H><Q><S><I><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><R><L><S><S><F><L><H><A><H><Q><R><I><H><A><E><I><K><P><Y><G><C><K><E><C><G><R><T><F><S><R><A><S><Y><L><V><Q><H><G><R><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><T><G><S><Y><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><I><S><R><H><Q><L><T><V><H><Q><R><V><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><H><V><H><L><T><Q><H><R><K><I><H><T><D><V><K><P><Y><E><C><K><E><C><G><K><T><F><S><R><A><S><Y><L><V><Q><H><S><R><I><H><T><G><K><K><P><Y><E><C><K><E><C><G><K><A><F><S><S><G><S><Y><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><K><C><G><K><A><F><T><V><Y><G><Q><L><I><G><H><Q><S><V><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><R><L><N><S><F><L><T><E><H><Q><R><V><H><T><G><E><K><P><F><K><C><K><K><C><G><K><T><F><R><Y><S><S><A><L><K><V><H><L><R><K><H><M><S><V><I><P>
May be involved in transcriptional regulation.<BOP>
P17039
P55040
GEM_HUMAN
RAS-like protein KIR
Homo
<M><T><L><N><N><V><T><M><R><Q><G><T><V><G><M><Q><P><Q><Q><Q><R><W><S><I><P><A><D><G><R><H><L><M><V><Q><K><E><P><H><Q><Y><S><H><R><N><R><H><S><A><T><P><E><D><H><C><R><R><S><W><S><S><D><S><T><D><S><V><I><S><S><E><S><G><N><T><Y><Y><R><V><V><L><I><G><E><Q><G><V><G><K><S><T><L><A><N><I><F><A><G><V><H><D><S><M><D><S><D><C><E><V><L><G><E><D><T><Y><E><R><T><L><M><V><D><G><E><S><A><T><I><I><L><L><D><M><W><E><N><K><G><E><N><E><W><L><H><D><H><C><M><Q><V><G><D><A><Y><L><I><V><Y><S><I><T><D><R><A><S><F><E><K><A><S><E><L><R><I><Q><L><R><R><A><R><Q><T><E><D><I><P><I><I><L><V><G><N><K><S><D><L><V><R><C><R><E><V><S><V><S><E><G><R><A><C><A><V><V><F><D><C><K><F><I><E><T><S><A><A><V><Q><H><N><V><K><E><L><F><E><G><I><V><R><Q><V><R><L><R><R><D><S><K><E><K><N><E><R><R><L><A><Y><Q><K><R><K><E><S><M><P><R><K><A><R><R><F><W><G><K><I><V><A><K><N><N><K><N><M><A><F><K><L><K><S><K><S><C><H><D><L><S><V><L>
Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.<BOP>
P55040
P15289
ARSA_HUMAN
Arylsulfatase A component C
Homo
<M><G><A><P><R><S><L><L><L><A><L><A><A><G><L><A><V><A><R><P><P><N><I><V><L><I><F><A><D><D><L><G><Y><G><D><L><G><C><Y><G><H><P><S><S><T><T><P><N><L><D><Q><L><A><A><G><G><L><R><F><T><D><F><Y><V><P><V><S><L><C><T><P><S><R><A><A><L><L><T><G><R><L><P><V><R><M><G><M><Y><P><G><V><L><V><P><S><S><R><G><G><L><P><L><E><E><V><T><V><A><E><V><L><A><A><R><G><Y><L><T><G><M><A><G><K><W><H><L><G><V><G><P><E><G><A><F><L><P><P><H><Q><G><F><H><R><F><L><G><I><P><Y><S><H><D><Q><G><P><C><Q><N><L><T><C><F><P><P><A><T><P><C><D><G><G><C><D><Q><G><L><V><P><I><P><L><L><A><N><L><S><V><E><A><Q><P><P><W><L><P><G><L><E><A><R><Y><M><A><F><A><H><D><L><M><A><D><A><Q><R><Q><D><R><P><F><F><L><Y><Y><A><S><H><H><T><H><Y><P><Q><F><S><G><Q><S><F><A><E><R><S><G><R><G><P><F><G><D><S><L><M><E><L><D><A><A><V><G><T><L><M><T><A><I><G><D><L><G><L><L><E><E><T><L><V><I><F><T><A><D><N><G><P><E><T><M><R><M><S><R><G><G><C><S><G><L><L><R><C><G><K><G><T><T><Y><E><G><G><V><R><E><P><A><L><A><F><W><P><G><H><I><A><P><G><V><T><H><E><L><A><S><S><L><D><L><L><P><T><L><A><A><L><A><G><A><P><L><P><N><V><T><L><D><G><F><D><L><S><P><L><L><L><G><T><G><K><S><P><R><Q><S><L><F><F><Y><P><S><Y><P><D><E><V><R><G><V><F><A><V><R><T><G><K><Y><K><A><H><F><F><T><Q><G><S><A><H><S><D><T><T><A><D><P><A><C><H><A><S><S><S><L><T><A><H><E><P><P><L><L><Y><D><L><S><K><D><P><G><E><N><Y><N><L><L><G><G><V><A><G><A><T><P><E><V><L><Q><A><L><K><Q><L><Q><L><L><K><A><Q><L><D><A><A><V><T><F><G><P><S><Q><V><A><R><G><E><D><P><A><L><Q><I><C><C><H><P><G><C><T><P><R><P><A><C><C><H><C><P><D><P><H><A>
Hydrolyzes cerebroside sulfate.<BOP>
P15289
Q32NB8
PGPS1_HUMAN
Phosphatidylglycerophosphate synthase 1
Homo
<M><A><V><A><A><A><A><A><A><G><P><V><F><W><R><R><L><L><G><L><L><P><G><R><P><G><L><A><A><L><L><G><R><L><S><D><R><L><G><R><N><R><D><R><Q><R><R><R><S><P><W><L><L><L><A><P><L><L><S><P><A><V><P><Q><V><T><S><P><P><C><C><L><C><P><E><G><V><H><R><F><Q><W><I><R><N><L><V><P><E><F><G><V><S><S><S><H><V><R><V><L><S><S><P><A><E><F><F><E><L><M><K><G><Q><I><R><V><A><K><R><R><V><V><M><A><S><L><Y><L><G><T><G><P><L><E><Q><E><L><V><D><C><L><E><S><T><L><E><K><S><L><Q><A><K><F><P><S><N><L><K><V><S><I><L><L><D><F><T><R><G><S><R><G><R><K><N><S><R><T><M><L><L><P><L><L><R><R><F><P><E><Q><V><R><V><S><L><F><H><T><P><H><L><R><G><L><L><R><L><L><I><P><E><R><F><N><E><T><I><G><L><Q><H><I><K><V><Y><L><F><D><N><S><V><I><L><S><G><A><N><L><S><D><S><Y><F><T><N><R><Q><D><R><Y><V><F><L><Q><D><C><A><E><I><A><D><F><F><T><E><L><V><D><A><V><G><D><V><S><L><Q><L><Q><G><D><D><T><V><Q><V><V><D><G><M><V><H><P><Y><K><G><D><R><A><E><Y><C><K><A><A><N><K><R><V><M><D><V><I><N><S><A><R><T><R><Q><Q><M><L><H><A><Q><T><F><H><S><N><S><L><L><T><Q><E><D><A><A><A><A><G><D><R><R><P><A><P><D><T><W><I><Y><P><L><I><Q><M><K><P><F><E><I><Q><I><D><E><I><V><T><E><T><L><L><T><E><A><E><R><G><A><K><V><Y><L><T><T><G><Y><F><N><L><T><Q><A><Y><M><D><L><V><L><G><T><R><A><E><Y><Q><I><L><L><A><S><P><E><V><N><G><F><F><G><A><K><G><V><A><G><A><I><P><A><A><Y><V><H><I><E><R><Q><F><F><S><E><V><C><S><L><G><Q><Q><E><R><V><Q><L><Q><E><Y><W><R><R><G><W><T><F><H><A><K><G><L><W><L><Y><L><A><G><S><S><L><P><C><L><T><L><I><G><S><P><N><F><G><Y><R><S><V><H><R><D><L><E><A><Q><I><A><I><V><T><E><N><Q><A><L><Q><Q><Q><L><H><Q><E><Q><E><Q><L><Y><L><R><S><G><V><V><S><S><A><T><F><E><Q><P><S><R><Q><V><K><L><W><V><K><M><V><T><P><L><I><K><N><F><F>
Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.<BOP>
Q32NB8