accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q9Y278 | HS3S2_HUMAN | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 | Homo | <M><A><Y><R><V><L><G><R><A><G><P><P><Q><P><R><R><A><R><R><L><L><F><A><F><T><L><S><L><S><C><T><Y><L><C><Y><S><F><L><C><C><C><D><D><L><G><R><S><R><L><L><G><A><P><R><C><L><R><G><P><S><A><G><G><Q><K><L><L><Q><K><S><R><P><C><D><P><S><G><P><T><P><S><E><P><S><A><P><S><A><P><A><A><A><V><P><A><P><R><L><S><G><S><N><H><S><G><S><P... | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate . Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS . Unlike HS3ST1/3-OST-1, does not convert non-anticoagul... | Q9Y278 |
Q9Y696 | CLIC4_HUMAN | Intracellular chloride ion channel protein p64H1 | Homo | <M><A><L><S><M><P><L><N><G><L><K><E><E><D><K><E><P><L><I><E><L><F><V><K><A><G><S><D><G><E><S><I><G><N><C><P><F><S><Q><R><L><F><M><I><L><W><L><K><G><V><V><F><S><V><T><T><V><D><L><K><R><K><P><A><D><L><Q><N><L><A><P><G><T><H><P><P><F><I><T><F><N><S><E><V><K><T><D><V><N><K><I><E><E><F><L><E><E><V><L><C><P><P><K><Y><L><K><L... | Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a pote... | Q9Y696 |
Q9ULP9 | TBC24_HUMAN | TBC1 domain family member 24 | Homo | <M><D><S><P><G><Y><N><C><F><V><D><K><D><K><M><D><A><A><I><Q><D><L><G><P><K><E><L><S><C><T><E><L><Q><E><L><K><Q><L><A><R><Q><G><Y><W><A><Q><S><H><A><L><R><G><K><V><Y><Q><R><L><I><R><D><I><P><C><R><T><V><T><P><D><A><S><V><Y><S><D><I><V><G><K><I><V><G><K><H><S><S><S><C><L><P><L><P><E><F><V><D><N><T><Q><V><P><S><Y><C><L><N... | May act as a GTPase-activating protein for Rab family protein(s) . Involved in neuronal projections development, probably through a negative modulation of ARF6 function . Involved in the regulation of synaptic vesicle trafficking .<BOP> | Q9ULP9 |
Q9UMX0 | UBQL1_HUMAN | Protein linking IAP with cytoskeleton 1 | Homo | <M><A><E><S><G><E><S><G><G><P><P><G><S><Q><D><S><A><A><G><A><E><G><A><G><A><P><A><A><A><A><S><A><E><P><K><I><M><K><V><T><V><K><T><P><K><E><K><E><E><F><A><V><P><E><N><S><S><V><Q><Q><F><K><E><E><I><S><K><R><F><K><S><H><T><D><Q><L><V><L><I><F><A><G><K><I><L><K><D><Q><D><T><L><S><Q><H><G><I><H><D><G><L><T><V><H><L><V><I><K... | Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress . Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis .<BOP> | Q9UMX0 |
Q9NWW9 | PLAT2_HUMAN | HRAS-like suppressor 2 | Homo | <M><A><L><A><R><P><R><P><R><L><G><D><L><I><E><I><S><R><F><G><Y><A><H><W><A><I><Y><V><G><D><G><Y><V><V><H><L><A><P><A><S><E><I><A><G><A><G><A><A><S><V><L><S><A><L><T><N><K><A><I><V><K><K><E><L><L><S><V><V><A><G><G><D><N><Y><R><V><N><N><K><H><D><D><R><Y><T><P><L><P><S><N><K><I><V><K><R><A><E><E><L><V><G><Q><E><L><P><Y><S... | Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltr... | Q9NWW9 |
Q02930 | CREB5_HUMAN | cAMP-response element-binding protein A | Homo | <M><I><Y><E><E><S><K><M><N><L><E><Q><E><R><P><F><V><C><S><A><P><G><C><S><Q><R><F><P><T><E><D><H><L><M><I><H><R><H><K><H><E><M><T><L><K><F><P><S><I><K><T><D><N><M><L><S><D><Q><T><P><T><P><T><R><F><L><K><N><C><E><E><V><G><L><F><S><E><L><D><C><S><L><E><H><E><F><R><K><A><Q><E><E><E><S><S><K><R><N><I><S><M><H><N><A><V><G><G... | Binds to the cAMP response element and activates transcription.<BOP> | Q02930 |
Q53H96 | P5CR3_HUMAN | Pyrroline-5-carboxylate reductase-like protein | Homo | <M><A><A><A><E><P><S><P><R><R><V><G><F><V><G><A><G><R><M><A><G><A><I><A><Q><G><L><I><R><A><G><K><V><E><A><Q><H><I><L><A><S><A><P><T><D><R><N><L><C><H><F><Q><A><L><G><C><R><T><T><H><S><N><Q><E><V><L><Q><S><C><L><L><V><I><F><A><T><K><P><H><V><L><P><A><V><L><A><E><V><A><P><V><V><T><T><E><H><I><L><V><S><V><A><A><G><V><S><L... | Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.<BOP> | Q53H96 |
Q8TC57 | M1AP_HUMAN | Spermatogenesis-associated protein 37 | Homo | <M><H><P><G><R><T><T><G><K><G><P><S><T><H><T><Q><I><D><Q><Q><P><P><R><L><L><I><V><H><I><A><L><P><S><W><A><D><I><C><T><N><L><C><E><A><L><Q><N><F><F><S><L><A><C><S><L><M><G><P><S><R><M><S><L><F><S><L><Y><M><V><Q><D><Q><H><E><C><I><L><P><F><V><Q><V><K><G><N><F><A><R><L><Q><T><C><I><S><E><L><R><M><L><Q><R><E><G><C><F><R><S... | Required for meiosis I progression during spermatogenesis.<BOP> | Q8TC57 |
Q00613 | HSF1_HUMAN | Heat shock transcription factor 1 | Homo | <M><D><L><P><V><G><P><G><A><A><G><P><S><N><V><P><A><F><L><T><K><L><W><T><L><V><S><D><P><D><T><D><A><L><I><C><W><S><P><S><G><N><S><F><H><V><F><D><Q><G><Q><F><A><K><E><V><L><P><K><Y><F><K><H><N><N><M><A><S><F><V><R><Q><L><N><M><Y><G><F><R><K><V><V><H><I><E><Q><G><G><L><V><K><P><E><R><D><D><T><E><F><Q><H><P><C><F><L><R><G... | (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300.<BOP> | Q00613 |
Q8NHA8 | OR1FC_HUMAN | Hs6M1-35P | Homo | <M><E><G><K><N><Q><T><N><I><S><E><F><L><L><L><G><F><S><S><W><Q><Q><Q><Q><V><L><L><F><A><L><F><L><C><L><Y><L><T><G><L><F><G><N><L><L><I><L><L><A><I><G><S><D><H><C><L><H><T><P><M><Y><F><F><L><A><N><L><S><L><V><D><L><C><L><P><S><A><T><V><P><K><M><L><L><N><I><Q><T><Q><T><Q><T><I><S><Y><P><G><C><L><A><Q><M><Y><F><C><M><M><F... | Odorant receptor.<BOP> | Q8NHA8 |
Q8NEY3 | SPAT4_HUMAN | Testis spermatocyte apoptosis-related gene 2 protein | Homo | <M><A><A><A><G><Q><E><K><G><Y><L><T><Q><T><A><A><A><L><D><K><S><P><S><L><S><P><Q><L><A><A><P><I><R><G><R><P><K><K><C><L><V><Y><P><H><A><P><K><S><S><R><L><S><R><S><V><L><R><W><L><Q><G><L><D><L><S><F><F><P><R><N><I><N><R><D><F><S><N><G><F><L><I><A><E><I><F><C><I><Y><Y><P><W><E><L><E><L><S><S><F><E><N><G><T><S><L><K><V><K... | May play a role in apoptosis regulation.<BOP> | Q8NEY3 |
P20160 | CAP7_HUMAN | Heparin-binding protein | Homo | <M><T><R><L><T><V><L><A><L><L><A><G><L><L><A><S><S><R><A><G><S><S><P><L><L><D><I><V><G><G><R><K><A><R><P><R><Q><F><P><F><L><A><S><I><Q><N><Q><G><R><H><F><C><G><G><A><L><I><H><A><R><F><V><M><T><A><A><S><C><F><Q><S><Q><N><P><G><V><S><T><V><V><L><G><A><Y><D><L><R><R><R><E><R><Q><S><R><Q><T><F><S><I><S><S><M><S><E><N><G><Y... | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged... | P20160 |
P35408 | PE2R4_HUMAN | Prostanoid EP4 receptor | Homo | <M><S><T><P><G><V><N><S><S><A><S><L><S><P><D><R><L><N><S><P><V><T><I><P><A><V><M><F><I><F><G><V><V><G><N><L><V><A><I><V><V><L><C><K><S><R><K><E><Q><K><E><T><T><F><Y><T><L><V><C><G><L><A><V><T><D><L><L><G><T><L><L><V><S><P><V><T><I><A><T><Y><M><K><G><Q><W><P><G><G><Q><P><L><C><E><Y><S><T><F><I><L><L><F><F><S><L><S><G><L... | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.<BO... | P35408 |
Q8NGV0 | OR2Y1_HUMAN | Olfactory receptor OR5-2 | Homo | <M><G><S><F><N><T><S><F><E><D><G><F><I><L><V><G><F><S><D><W><P><Q><L><E><P><I><L><F><V><F><I><F><I><F><Y><S><L><T><L><F><G><N><T><I><I><I><A><L><S><W><L><D><L><R><L><H><T><P><M><Y><F><F><L><S><H><L><S><L><L><D><L><C><F><T><T><S><T><V><P><Q><L><L><I><N><L><C><G><V><D><R><T><I><T><R><G><G><C><V><A><Q><L><F><I><Y><L><A><L... | Odorant receptor.<BOP> | Q8NGV0 |
P86791 | CCZ1_HUMAN | Vacuolar fusion protein CCZ1 homolog | Homo | <M><A><A><A><A><A><G><A><G><S><G><P><W><A><A><Q><E><K><Q><F><P><P><A><L><L><S><F><F><I><Y><N><P><R><F><G><P><R><E><G><Q><E><E><N><K><I><L><F><Y><H><P><N><E><V><E><K><N><E><K><I><R><N><V><G><L><C><E><A><I><V><Q><F><T><R><T><F><S><P><S><K><P><A><K><S><L><H><T><Q><K><N><R><Q><F><F><N><E><P><E><E><N><F><W><M><V><M><V><V><R... | Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form .<BOP> | P86791 |
A6NCE7 | MP3B2_HUMAN | Microtubule-associated proteins 1A/1B light chain 3B-like | Homo | <M><P><S><E><K><T><F><K><Q><R><R><T><F><E><Q><R><V><E><D><V><R><L><I><R><E><Q><H><P><T><K><I><P><V><I><I><E><R><Y><K><G><E><K><Q><L><P><V><L><D><K><T><K><F><L><V><P><D><H><V><N><M><S><E><L><I><K><I><I><R><R><R><L><Q><L><N><A><N><Q><A><F><F><L><L><V><N><G><H><S><M><V><S><V><S><T><P><I><S><E><V><Y><E><S><E><K><D><E><D><G... | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response... | A6NCE7 |
P48163 | MAOX_HUMAN | Malic enzyme 1 | Homo | <M><E><P><E><A><P><R><R><R><H><T><H><Q><R><G><Y><L><L><T><R><N><P><H><L><N><K><D><L><A><F><T><L><E><E><R><Q><Q><L><N><I><H><G><L><L><P><P><S><F><N><S><Q><E><I><Q><V><L><R><V><V><K><N><F><E><H><L><N><S><D><F><D><R><Y><L><L><L><M><D><L><Q><D><R><N><E><K><L><F><Y><R><V><L><T><S><D><I><E><K><F><M><P><I><V><Y><T><P><T><V><G... | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate.<BOP> | P48163 |
Q96AZ6 | ISG20_HUMAN | Promyelocytic leukemia nuclear body-associated protein ISG20 | Homo | <M><A><G><S><R><E><V><V><A><M><D><C><E><M><V><G><L><G><P><H><R><E><S><G><L><A><R><C><S><L><V><N><V><H><G><A><V><L><Y><D><K><F><I><R><P><E><G><E><I><T><D><Y><R><T><R><V><S><G><V><T><P><Q><H><M><V><G><A><T><P><F><A><V><A><R><L><E><I><L><Q><L><L><K><G><K><L><V><V><G><H><D><L><K><H><D><F><Q><A><L><K><E><D><M><S><G><Y><T><I... | Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play... | Q96AZ6 |
P0DOX5 | IGG1_HUMAN | Immunoglobulin gamma-1 heavy chain NIE | Homo | <Q><V><Q><L><V><Q><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><R><Y><T><I><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><M><S><Y><N><G><N><N><K><H><Y><A><D><S><V><N><G><R><F><T><I><S><R><N><D><S><K><N><T><L><Y><L><N><M><N><S><L><R><P><E><D><T><A><V><Y><Y><C><A><R><I><R><D><T><A><M><F><F><A... | Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocy... | P0DOX5 |
Q9BQ15 | SOSB1_HUMAN | Single-stranded DNA-binding protein 1 | Homo | <M><T><T><E><T><F><V><K><D><I><K><P><G><L><K><N><L><N><L><I><F><I><V><L><E><T><G><R><V><T><K><T><K><D><G><H><E><V><R><T><C><K><V><A><D><K><T><G><S><I><N><I><S><V><W><D><D><V><G><N><L><I><Q><P><G><D><I><I><R><L><T><K><G><Y><A><S><V><F><K><G><C><L><T><L><Y><T><G><R><G><G><D><L><Q><K><I><G><E><F><C><M><V><Y><S><E><V><P><N... | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and... | Q9BQ15 |
P02008 | HBAZ_HUMAN | Zeta-globin | Homo | <M><S><L><T><K><T><E><R><T><I><I><V><S><M><W><A><K><I><S><T><Q><A><D><T><I><G><T><E><T><L><E><R><L><F><L><S><H><P><Q><T><K><T><Y><F><P><H><F><D><L><H><P><G><S><A><Q><L><R><A><H><G><S><K><V><V><A><A><V><G><D><A><V><K><S><I><D><D><I><G><G><A><L><S><K><L><S><E><L><H><A><Y><I><L><R><V><D><P><V><N><F><K><L><L><S><H><C><L><L... | The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.<BOP> | P02008 |
Q8NHY2 | COP1_HUMAN | RING-type E3 ubiquitin transferase RFWD2 | Homo | <M><S><G><S><R><Q><A><G><S><G><S><A><G><T><S><P><G><S><S><A><A><S><S><V><T><S><A><S><S><S><L><S><S><S><P><S><P><P><S><V><A><V><S><A><A><A><L><V><S><G><G><V><A><Q><A><A><G><S><G><G><L><G><G><P><V><R><P><V><L><V><A><P><A><V><S><G><S><G><G><G><A><V><S><T><G><L><S><R><H><S><C><A><A><R><P><S><A><G><V><G><G><S><S><S><S><L><G... | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination an... | Q8NHY2 |
Q13049 | TRI32_HUMAN | Zinc finger protein HT2A | Homo | <M><A><A><A><A><A><S><H><L><N><L><D><A><L><R><E><V><L><E><C><P><I><C><M><E><S><F><T><E><E><Q><L><R><P><K><L><L><H><C><G><H><T><I><C><R><Q><C><L><E><K><L><L><A><S><S><I><N><G><V><R><C><P><F><C><S><K><I><T><R><I><T><S><L><T><Q><L><T><D><N><L><T><V><L><K><I><I><D><T><A><G><L><S><E><A><V><G><L><L><M><C><R><S><C><G><R><R><L... | (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo .<BOP> | Q13049 |
P01160 | ANF_HUMAN | Atriopeptin III | Homo | <M><S><S><F><S><T><T><T><V><S><F><L><L><L><L><A><F><Q><L><L><G><Q><T><R><A><N><P><M><Y><N><A><V><S><N><A><D><L><M><D><F><K><N><L><L><D><H><L><E><E><K><M><P><L><E><D><E><V><V><P><P><Q><V><L><S><E><P><N><E><E><A><G><A><A><L><S><P><L><P><E><V><P><P><W><T><G><E><V><S><P><A><Q><R><D><G><G><A><L><G><R><G><P><W><D><S><S><D><R... | May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.<BOP> | P01160 |
P13987 | CD59_HUMAN | Protectin | Homo | <M><G><I><Q><G><G><S><V><L><F><G><L><L><L><V><L><A><V><F><C><H><S><G><H><S><L><Q><C><Y><N><C><P><N><P><T><A><D><C><K><T><A><V><N><C><S><S><D><F><D><A><C><L><I><T><K><A><G><L><Q><V><Y><N><K><C><W><K><F><E><H><C><N><F><N><D><V><T><T><R><L><R><E><N><E><L><T><Y><Y><C><C><K><K><D><L><C><N><F><N><E><Q><L><E><N><G><G><T><S><L... | The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.<BOP> | P13987 |
Q86UQ8 | NFE4_HUMAN | Transcription factor NF-E4 | Homo | <M><P><R><V><V><C><W><H><T><L><K><S><L><N><G><Y><K><N><L><S><S><G><A><E><T><R><E><G><L><R><S><S><S><P><V><D><L><P><L><R><P><R><K><Q><A><T><A><A><G><Q><R><K><L><L><S><L><Q><L><L><L><C><A><C><T><S><V><T><D><L><T><Y><W><G><P><A><G><H><G><A><T><A><P><H><R><S><L><L><A><I><H><L><H><L><V><P><A><S><S><A><A><M><K><A><T><G><P><H... | Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage... | Q86UQ8 |
A1Z1Q3 | MACD2_HUMAN | [Protein ADP-ribosylglutamate] hydrolase MACROD2 | Homo | <M><Y><P><S><N><K><K><K><K><V><W><R><E><E><K><E><R><L><L><K><M><T><L><E><E><R><R><K><E><Y><L><R><D><Y><I><P><L><N><S><I><L><S><W><K><E><E><M><K><G><K><G><Q><N><D><E><E><N><T><Q><E><T><S><Q><V><K><K><S><L><T><E><K><V><S><L><Y><R><G><D><I><T><L><L><E><V><D><A><I><V><N><A><A><N><A><S><L><L><G><G><G><G><V><D><G><C><I><H><R... | Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety . Inactive towards proteins bearing poly-ADP-ribose . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins .<BOP> | A1Z1Q3 |
Q6NXP2 | GAR1A_HUMAN | Golgi-associated RAB2 interactor protein 1A | Homo | <M><S><K><I><R><G><L><P><P><E><V><R><E><P><G><P><G><V><E><L><G><V><E><N><G><L><L><C><Q><L><I><H><S><P><E><F><N><L><F><S><N><S><V><V><F><E><S><N><F><I><Q><T><H><V><P><E><A><D><F><Q><V><T><K><P><G><N><W><R><D><V><C><E><G><S><A><T><V><I><L><G><V><T><S><S><V><P><S><L><P><L><P><N><V><L><L><M><A><N><V><T><W><P><Q><G><P><F><T... | RAB2B effector protein required for accurate acrosome formation and normal male fertility.<BOP> | Q6NXP2 |
P07098 | LIPG_HUMAN | Gastric triacylglycerol lipase | Homo | <M><W><L><L><L><T><M><A><S><L><I><S><V><L><G><T><T><H><G><L><F><G><K><L><H><P><G><S><P><E><V><T><M><N><I><S><Q><M><I><T><Y><W><G><Y><P><N><E><E><Y><E><V><V><T><E><D><G><Y><I><L><E><V><N><R><I><P><Y><G><K><K><N><S><G><N><T><G><Q><R><P><V><V><F><L><Q><H><G><L><L><A><S><A><T><N><W><I><S><N><L><P><N><N><S><L><A><F><I><L><A... | Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol . Shows a preferential hydrolysis at the sn-3 position of triacylglycerol .<BOP> | P07098 |
Q9P242 | NYAP2_HUMAN | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Homo | <M><I><S><S><K><M><M><S><S><N><P><E><E><D><P><L><D><T><F><L><Q><Y><I><E><D><M><G><M><K><A><Y><D><G><L><V><I><Q><N><A><S><D><I><A><R><E><N><D><R><L><R><N><E><T><N><L><A><Y><L><K><E><K><N><E><K><R><R><R><Q><E><E><A><I><K><R><I><G><G><E><V><G><R><G><H><E><G><S><Y><V><G><K><H><F><R><M><G><F><M><T><M><P><A><P><Q><D><R><L><P... | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.<BOP> | Q9P242 |
O95073 | FSBP_HUMAN | Fibrinogen silencer-binding protein | Homo | <M><V><G><K><A><R><S><S><N><F><T><L><S><E><K><L><D><L><L><K><L><V><K><P><Y><V><K><I><L><E><E><H><T><N><K><H><S><V><I><V><E><K><N><R><C><W><D><I><I><A><V><N><Y><N><A><I><G><V><D><R><P><P><R><T><A><Q><G><L><R><T><L><Y><K><R><L><K><E><Y><A><K><Q><E><L><L><Q><Q><K><E><T><Q><S><D><F><K><S><N><I><S><E><P><T><K><K><V><M><E><M... | Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.<BOP> | O95073 |
Q8IV42 | PSTK_HUMAN | O-phosphoseryl-tRNA(Sec) kinase | Homo | <M><K><T><A><E><N><I><R><G><T><G><S><D><G><P><R><K><R><G><L><C><V><L><C><G><L><P><A><A><G><K><S><T><F><A><R><A><L><A><H><R><L><Q><Q><E><Q><G><W><A><I><G><V><V><A><Y><D><D><V><M><P><D><A><F><L><A><G><A><R><A><R><P><A><P><S><Q><W><K><L><L><R><Q><E><L><L><K><Y><L><E><Y><F><L><M><A><V><I><N><G><C><Q><M><S><V><P><P><N><R><T... | Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.<BOP> | Q8IV42 |
P05160 | F13B_HUMAN | Transglutaminase B chain | Homo | <M><R><L><K><N><L><T><F><I><I><I><L><I><I><S><G><E><L><Y><A><E><E><K><P><C><G><F><P><H><V><E><N><G><R><I><A><Q><Y><Y><Y><T><F><K><S><F><Y><F><P><M><S><I><D><K><K><L><S><F><F><C><L><A><G><Y><T><T><E><S><G><R><Q><E><E><Q><T><T><C><T><T><E><G><W><S><P><E><P><R><C><F><K><K><C><T><K><P><D><L><S><N><G><Y><I><S><D><V><K><L><L... | The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.<BOP> | P05160 |
P20810 | ICAL_HUMAN | Sperm BS-17 component | Homo | <M><N><P><T><E><T><K><A><I><P><V><S><Q><Q><M><E><G><P><H><L><P><N><K><K><K><H><K><K><Q><A><V><K><T><E><P><E><K><K><S><Q><S><T><K><L><S><V><V><H><E><K><K><S><Q><E><G><K><P><K><E><H><T><E><P><K><S><L><P><K><Q><A><S><D><T><G><S><N><D><A><H><N><K><K><A><V><S><R><S><A><E><Q><Q><P><S><E><K><S><T><E><P><K><T><K><P><Q><D><M><I... | Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.<BOP> | P20810 |
P36896 | ACV1B_HUMAN | Serine/threonine-protein kinase receptor R2 | Homo | <M><A><E><S><A><G><A><S><S><F><F><P><L><V><V><L><L><L><A><G><S><G><G><S><G><P><R><G><V><Q><A><L><L><C><A><C><T><S><C><L><Q><A><N><Y><T><C><E><T><D><G><A><C><M><V><S><I><F><N><L><D><G><M><E><H><H><V><R><T><C><I><P><K><V><E><L><V><P><A><G><K><P><F><Y><C><L><S><S><E><D><L><R><N><T><H><C><C><Y><T><D><Y><C><N><R><I><D><L><R... | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiatio... | P36896 |
P04196 | HRG_HUMAN | Histidine-proline-rich glycoprotein | Homo | <M><K><A><L><I><A><A><L><L><L><I><T><L><Q><Y><S><C><A><V><S><P><T><D><C><S><A><V><E><P><E><A><E><K><A><L><D><L><I><N><K><R><R><R><D><G><Y><L><F><Q><L><L><R><I><A><D><A><H><L><D><R><V><E><N><T><T><V><Y><Y><L><V><L><D><V><Q><E><S><D><C><S><V><L><S><R><K><Y><W><N><D><C><E><P><P><D><S><R><R><P><S><E><I><V><I><G><Q><C><K><V... | Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-su... | P04196 |
Q9H9A7 | RMI1_HUMAN | FAAP75 | Homo | <M><N><V><T><S><I><A><L><R><A><E><T><W><L><L><A><A><W><H><V><K><V><P><P><M><W><L><E><A><C><I><N><W><I><Q><E><E><N><N><N><V><N><L><S><Q><A><Q><M><N><K><Q><V><F><E><Q><W><L><L><T><D><L><R><D><L><E><H><P><L><L><P><D><G><I><L><E><I><P><K><G><E><L><N><G><F><Y><A><L><Q><I><N><S><L><V><D><V><S><Q><P><A><Y><S><Q><I><Q><K><L><R... | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylatio... | Q9H9A7 |
Q9BWW7 | SCRT1_HUMAN | Scratch homolog 1 zinc finger protein | Homo | <M><P><R><S><F><L><V><K><K><V><K><L><D><A><F><S><S><A><D><L><E><S><A><Y><G><R><A><R><S><D><L><G><A><P><L><H><D><K><G><Y><L><S><D><Y><V><G><P><S><S><V><Y><D><G><D><A><E><A><A><L><L><K><G><P><S><P><E><P><M><Y><A><A><A><V><R><G><E><L><G><P><A><A><A><G><S><A><P><P><P><T><P><R><P><E><L><A><T><A><A><G><G><Y><I><N><G><D><A><A... | Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation.<BOP> | Q9BWW7 |
P04180 | LCAT_HUMAN | Platelet-activating factor acetylhydrolase | Homo | <M><G><P><P><G><S><P><W><Q><W><V><T><L><L><L><G><L><L><L><P><P><A><A><P><F><W><L><L><N><V><L><F><P><P><H><T><T><P><K><A><E><L><S><N><H><T><R><P><V><I><L><V><P><G><C><L><G><N><Q><L><E><A><K><L><D><K><P><D><V><V><N><W><M><C><Y><R><K><T><E><D><F><F><T><I><W><L><D><L><N><M><F><L><P><L><G><V><D><C><W><I><D><N><T><R><V><V><Y... | Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) . The ... | P04180 |
Q16570 | ACKR1_HUMAN | Plasmodium vivax receptor | Homo | <M><G><N><C><L><H><R><A><E><L><S><P><S><T><E><N><S><S><Q><L><D><F><E><D><V><W><N><S><S><Y><G><V><N><D><S><F><P><D><G><D><Y><G><A><N><L><E><A><A><A><P><C><H><S><C><N><L><L><D><D><S><A><L><P><F><F><I><L><T><S><V><L><G><I><L><A><S><S><T><V><L><F><M><L><F><R><P><L><F><R><W><Q><L><C><P><G><W><P><V><L><A><Q><L><A><V><G><S><A... | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or che... | Q16570 |
P33992 | MCM5_HUMAN | P1-CDC46 | Homo | <M><S><G><F><D><D><P><G><I><F><Y><S><D><S><F><G><G><D><A><Q><A><D><E><G><Q><A><R><K><S><Q><L><Q><R><R><F><K><E><F><L><R><Q><Y><R><V><G><T><D><R><T><G><F><T><F><K><Y><R><D><E><L><K><R><H><Y><N><L><G><E><Y><W><I><E><V><E><M><E><D><L><A><S><F><D><E><D><L><A><D><Y><L><Y><K><Q><P><A><E><H><L><Q><L><L><E><E><A><A><K><E><V><A... | Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which... | P33992 |
Q8NFU1 | BEST2_HUMAN | Vitelliform macular dystrophy 2-like protein 1 | Homo | <M><T><V><T><Y><T><A><R><V><A><N><A><R><F><G><G><F><S><Q><L><L><L><L><W><R><G><S><I><Y><K><L><L><W><R><E><L><L><C><F><L><G><F><Y><M><A><L><S><A><A><Y><R><F><V><L><T><E><G><Q><K><R><Y><F><E><K><L><V><I><Y><C><D><Q><Y><A><S><L><I><P><V><S><F><V><L><G><F><Y><V><T><L><V><V><N><R><W><W><S><Q><Y><L><C><M><P><L><P><D><A><L><M... | Forms calcium-sensitive chloride channels. Permeable to bicarbonate.<BOP> | Q8NFU1 |
Q969L2 | MAL2_HUMAN | Protein MAL2 | Homo | <M><S><A><G><G><A><S><V><P><P><P><P><N><P><A><V><S><F><P><P><P><R><V><T><L><P><A><G><P><D><I><L><R><T><Y><S><G><A><F><V><C><L><E><I><L><F><G><G><L><V><W><I><L><V><A><S><S><N><V><P><L><P><L><L><Q><G><W><V><M><F><V><S><V><T><A><F><F><F><S><L><L><F><L><G><M><F><L><S><G><M><V><A><Q><I><D><A><N><W><N><F><L><D><F><A><Y><H><F... | Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.<BOP> | Q969L2 |
Q9BXS4 | TMM59_HUMAN | Liver membrane-bound protein | Homo | <M><A><A><P><K><G><S><L><W><V><R><T><Q><L><G><L><P><P><L><L><L><L><T><M><A><L><A><G><G><S><G><T><A><S><A><E><A><F><D><S><V><L><G><D><T><A><S><C><H><R><A><C><Q><L><T><Y><P><L><H><T><Y><P><K><E><E><E><L><Y><A><C><Q><R><G><C><R><L><F><S><I><C><Q><F><V><D><D><G><I><D><L><N><R><T><K><L><E><C><E><S><A><C><T><E><A><Y><S><Q><S... | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy . Modulates the O-glyc... | Q9BXS4 |
P62684 | GA113_HUMAN | HERV-K_19p13.11 provirus ancestral Gag polyprotein | Homo | <M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><V><S><V><S><D><A... | The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding ... | P62684 |
Q9BSK0 | MALD1_HUMAN | MARVEL domain-containing protein 1 | Homo | <M><L><P><P><P><P><R><Q><P><P><P><Q><A><R><A><A><R><G><A><V><R><L><Q><R><P><F><L><R><S><P><L><G><V><L><R><L><L><Q><L><L><A><G><A><A><F><W><I><T><I><A><T><S><K><Y><Q><G><P><V><H><F><A><L><F><V><S><V><L><F><W><L><L><T><L><G><L><Y><F><L><T><L><L><G><K><H><E><L><V><P><V><L><G><S><R><W><L><M><V><N><V><A><H><D><V><L><A><A><A... | Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.<BOP> | Q9BSK0 |
Q53T94 | TAF1B_HUMAN | Transcription initiation factor SL1/TIF-IB subunit B | Homo | <M><D><L><E><E><A><E><E><F><K><E><R><C><T><Q><C><A><A><V><S><W><G><L><T><D><E><G><K><Y><Y><C><T><S><C><H><N><V><T><E><R><Y><Q><E><V><T><N><T><D><L><I><P><N><T><Q><I><K><A><L><N><R><G><L><K><K><K><N><N><T><E><K><G><W><D><W><Y><V><C><E><G><F><Q><Y><I><L><Y><Q><Q><A><E><A><L><K><N><L><G><V><G><P><E><L><K><N><D><V><L><H><N... | Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role... | Q53T94 |
Q96NB1 | CEP20_HUMAN | null | Homo | <M><A><T><V><A><E><L><K><A><V><L><K><D><T><L><E><K><K><G><V><L><G><H><L><K><A><R><I><R><A><E><V><F><N><A><L><D><D><D><R><E><P><R><P><S><L><S><H><E><N><L><L><I><N><E><L><I><R><E><Y><L><E><F><N><K><Y><K><Y><T><A><S><V><L><I><A><E><S><G><Q><P><V><V><P><L><D><R><Q><F><L><I><H><E><L><N><A><F><E><E><S><K><D><N><T><I><P><L><L... | Involved in the biogenesis of cilia . Required for the recruitment of PLK1 to centrosomes and S phase progression .<BOP> | Q96NB1 |
Q8TAA3 | PSMA8_HUMAN | Proteasome subunit alpha-type 7-like | Homo | <M><A><S><R><Y><D><R><A><I><T><V><F><S><P><D><G><H><L><F><Q><V><E><Y><A><Q><E><A><V><K><K><G><S><T><A><V><G><I><R><G><T><N><I><V><V><L><G><V><E><K><K><S><V><A><K><L><Q><D><E><R><T><V><R><K><I><C><A><L><D><D><H><V><C><M><A><F><A><V><L><T><I><F><I><G><L><T><A><D><A><R><V><V><I><N><R><A><R><V><E><C><Q><S><H><K><L><T><V><E... | Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a ... | Q8TAA3 |
Q8NI38 | IKBD_HUMAN | TA-NFKBH | Homo | <M><E><A><G><P><W><R><V><S><A><P><P><S><G><P><P><Q><F><P><A><V><V><P><G><P><S><L><E><V><A><R><A><H><M><L><A><L><G><P><Q><Q><L><L><A><Q><D><E><E><G><D><T><L><L><H><L><F><A><A><R><G><L><R><W><A><A><Y><A><A><A><E><V><L><Q><V><Y><R><R><L><D><I><R><E><H><K><G><K><T><P><L><L><V><A><A><A><A><N><Q><P><L><I><V><E><D><L><L><N><L... | Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced ... | Q8NI38 |
Q9BSL1 | UBAC1_HUMAN | Kip1 ubiquitination-promoting complex protein 2 | Homo | <M><F><V><Q><E><E><K><I><F><A><G><K><V><L><R><L><H><I><C><A><S><D><G><A><E><W><L><E><E><A><T><E><D><T><S><V><E><K><L><K><E><R><C><L><K><H><C><A><H><G><S><L><E><D><P><K><S><I><T><H><H><K><L><I><H><A><A><S><E><R><V><L><S><D><A><R><T><I><L><E><E><N><I><Q><D><Q><D><V><L><L><L><I><K><K><R><A><P><S><P><L><P><K><M><A><D><V><S... | Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<BOP> | Q9BSL1 |
Q5SXM8 | DNLZ_HUMAN | mtHsp70-escort protein | Homo | <M><L><R><T><A><L><R><G><A><P><R><L><L><S><R><V><Q><P><R><A><P><C><L><R><R><L><W><G><R><G><A><R><P><E><V><A><G><R><R><R><A><W><A><W><G><W><R><R><S><S><S><E><Q><G><P><G><P><A><A><A><L><G><R><V><E><A><A><H><Y><Q><L><V><Y><T><C><K><V><C><G><T><R><S><S><K><R><I><S><K><L><A><Y><H><Q><G><V><V><I><V><T><C><P><G><C><Q><N><H><H... | May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.<BOP> | Q5SXM8 |
O60235 | TM11D_HUMAN | Transmembrane protease serine 11D catalytic chain | Homo | <M><Y><R><P><A><R><V><T><S><T><S><R><F><L><N><P><Y><V><V><C><F><I><V><V><A><G><V><V><I><L><A><V><T><I><A><L><L><V><Y><F><L><A><F><D><Q><K><S><Y><F><Y><R><S><S><F><Q><L><L><N><V><E><Y><N><S><Q><L><N><S><P><A><T><Q><E><Y><R><T><L><S><G><R><I><E><S><L><I><T><K><T><F><K><E><S><N><L><R><N><Q><F><I><R><A><H><V><A><K><L><R><Q... | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycop... | O60235 |
O95257 | GA45G_HUMAN | DNA damage-inducible transcript 2 protein | Homo | <M><T><L><E><E><V><R><G><Q><D><T><V><P><E><S><T><A><R><M><Q><G><A><G><K><A><L><H><E><L><L><L><S><A><Q><R><Q><G><C><L><T><A><G><V><Y><E><S><A><K><V><L><N><V><D><P><D><N><V><T><F><C><V><L><A><A><G><E><E><D><E><G><D><I><A><L><Q><I><H><F><T><L><I><Q><A><F><C><C><E><N><D><I><D><I><V><R><V><G><D><V><Q><R><L><A><A><I><V><G><A... | Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.<BOP> | O95257 |
P80217 | IN35_HUMAN | Interferon-induced 35 kDa protein | Homo | <M><S><A><P><L><D><A><A><L><H><A><L><Q><E><E><Q><A><R><L><K><M><R><L><W><D><L><Q><Q><L><R><K><E><L><G><D><S><P><K><D><K><V><P><F><S><V><P><K><I><P><L><V><F><R><G><H><T><Q><Q><D><P><E><V><P><K><S><L><V><S><N><L><R><I><H><C><P><L><L><A><G><S><A><L><I><T><F><D><D><P><K><V><A><E><Q><V><L><Q><Q><K><E><H><T><I><N><M><E><E><C... | Acts as a signaling pathway regulator involved in innate immune system response . In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphoryla... | P80217 |
P53611 | PGTB2_HUMAN | Type II protein geranyl-geranyltransferase subunit beta | Homo | <M><G><T><P><Q><K><D><V><I><I><K><S><D><A><P><D><T><L><L><L><E><K><H><A><D><Y><I><A><S><Y><G><S><K><K><D><D><Y><E><Y><C><M><S><E><Y><L><R><M><S><G><I><Y><W><G><L><T><V><M><D><L><M><G><Q><L><H><R><M><N><R><E><E><I><L><A><F><I><K><S><C><Q><H><E><C><G><G><I><S><A><S><I><G><H><D><P><H><L><L><Y><T><L><S><A><V><Q><I><L><T><L... | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.<BOP> | P53611 |
Q9NUJ1 | ABHDA_HUMAN | Mycophenolic acid acyl-glucuronide esterase, mitochondrial | Homo | <M><A><V><A><R><L><A><A><V><A><A><W><V><P><C><R><S><W><G><W><A><A><V><P><F><G><P><H><R><G><L><S><V><L><L><A><R><I><P><Q><R><A><P><R><W><L><P><A><C><R><Q><K><T><S><L><S><F><L><N><R><P><D><L><P><N><L><A><Y><K><K><L><K><G><K><S><P><G><I><I><F><I><P><G><Y><L><S><Y><M><N><G><T><K><A><L><A><I><E><E><F><C><K><S><L><G><H><A><C... | Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins . Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability . Also catalyzes the de... | Q9NUJ1 |
Q9UKI2 | BORG2_HUMAN | MSE55-related Cdc42-binding protein | Homo | <M><P><A><K><T><P><I><Y><L><K><A><A><N><N><K><K><G><K><K><F><K><L><R><D><I><L><S><P><D><M><I><S><P><P><L><G><D><F><R><H><T><I><H><I><G><K><E><G><Q><H><D><V><F><G><D><I><S><F><L><Q><G><N><Y><E><L><L><P><G><N><Q><E><K><A><H><L><G><Q><F><P><G><H><N><E><F><F><R><A><N><S><T><S><D><S><V><F><T><E><T><P><S><P><V><L><K><N><A><I... | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts.<BOP> | Q9UKI2 |
P68871 | HBB_HUMAN | Spinorphin | Homo | <M><V><H><L><T><P><E><E><K><S><A><V><T><A><L><W><G><K><V><N><V><D><E><V><G><G><E><A><L><G><R><L><L><V><V><Y><P><W><T><Q><R><F><F><E><S><F><G><D><L><S><T><P><D><A><V><M><G><N><P><K><V><K><A><H><G><K><K><V><L><G><A><F><S><D><G><L><A><H><L><D><N><L><K><G><T><F><A><T><L><S><E><L><H><C><D><K><L><H><V><D><P><E><N><F><R><L><L... | Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.<BOP> | P68871 |
Q9GZX6 | IL22_HUMAN | IL-10-related T-cell-derived-inducible factor | Homo | <M><A><A><L><Q><K><S><V><S><S><F><L><M><G><T><L><A><T><S><C><L><L><L><L><A><L><L><V><Q><G><G><A><A><A><P><I><S><S><H><C><R><L><D><K><S><N><F><Q><Q><P><Y><I><T><N><R><T><F><M><L><A><K><E><A><S><L><A><D><N><N><T><D><V><R><L><I><G><E><K><L><F><H><G><V><S><M><S><E><R><C><Y><L><M><K><Q><V><L><N><F><T><L><E><E><V><L><F><P><Q... | Cytokine that plays a critical role in modulating tissue responses during inflammation . Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage . Unlike most of the cytokines, has no effect on immune cells. Signals throug... | Q9GZX6 |
Q8IZM9 | S38A6_HUMAN | Solute carrier family 38 member 6 | Homo | <M><E><A><S><W><G><S><F><N><A><E><R><G><W><Y><V><S><V><Q><Q><P><E><E><A><E><A><E><E><L><S><P><L><L><S><N><E><L><H><R><Q><R><S><P><G><V><S><F><G><L><S><V><F><N><L><M><N><A><I><M><G><S><G><I><L><G><L><A><Y><V><L><A><N><T><G><V><F><G><F><S><F><L><L><L><T><V><A><L><L><A><S><Y><S><V><H><L><L><L><S><M><C><I><Q><T><A><V><T><S... | Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.<BOP> | Q8IZM9 |
Q58A44 | PCOTH_HUMAN | C1QTNF9B antisense gene protein 1 | Homo | <M><W><I><L><S><N><L><M><G><T><S><E><E><G><N><L><L><S><T><V><S><P><T><V><K><A><L><F><G><K><T><R><V><S><P><I><F><P><F><S><P><R><S><P><F><Q><P><L><I><P><R><T><P><G><S><P><W><G><P><V><G><P><A><S><P><L><G><P><G><F><P><I><G><P><M><G><P><G><K><P><V><G><P><K><G><P><M><L><P><L><G><P><S><G><P><V><G><P><T><S><P><L><F><P><F><C><P... | May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.<BOP> | Q58A44 |
Q96GD3 | SCMH1_HUMAN | Sex comb on midleg homolog 1 | Homo | <M><L><V><C><Y><S><V><L><A><C><E><I><L><W><D><L><P><C><S><I><M><G><S><P><L><G><H><F><T><W><D><K><Y><L><K><E><T><C><S><V><P><A><P><V><H><C><F><K><Q><S><Y><T><P><P><S><N><E><F><K><I><S><M><K><L><E><A><Q><D><P><R><N><T><T><S><T><C><I><A><T><V><V><G><L><T><G><A><R><L><R><L><R><L><D><G><S><D><N><K><N><D><F><W><R><L><V><D><S... | Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.<BOP> | Q96GD3 |
Q9UHP7 | CLC2D_HUMAN | Osteoclast inhibitory lectin | Homo | <M><H><D><S><N><N><V><E><K><D><I><T><P><S><E><L><P><A><N><P><G><C><L><H><S><K><E><H><S><I><K><A><T><L><I><W><R><L><F><F><L><I><M><F><L><T><I><I><V><C><G><M><V><A><A><L><S><A><I><R><A><N><C><H><Q><E><P><S><V><C><L><Q><A><A><C><P><E><S><W><I><G><F><Q><R><K><C><F><Y><F><S><D><D><T><K><N><W><T><S><S><Q><R><F><C><D><S><Q><D... | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis . Inhibits osteoclast formation . Inhibits bone resorption . Modulates the release of interferon-gamma . Binds high molecular weight sulfated glycosaminoglycans .<BOP> | Q9UHP7 |
P0C7X2 | ZN688_HUMAN | Zinc finger protein 688 | Homo | <M><A><P><P><P><A><P><L><L><A><P><R><P><G><E><T><R><P><G><C><R><K><P><G><T><V><S><F><A><D><V><A><V><Y><F><S><P><E><E><W><G><C><L><R><P><A><Q><R><A><L><Y><R><D><V><M><Q><E><T><Y><G><H><L><G><A><L><G><F><P><G><P><K><P><A><L><I><S><W><M><E><Q><E><S><E><A><W><S><P><A><A><Q><D><P><E><K><G><E><R><L><G><G><A><R><R><G><D><V><P... | May be involved in transcriptional regulation.<BOP> | P0C7X2 |
Q8TD06 | AGR3_HUMAN | Protein disulfide isomerase family A, member 18 | Homo | <M><M><L><H><S><A><L><G><L><C><L><L><L><V><T><V><S><S><N><L><A><I><A><I><K><K><E><K><R><P><P><Q><T><L><S><R><G><W><G><D><D><I><T><W><V><Q><T><Y><E><E><G><L><F><Y><A><Q><K><S><K><K><P><L><M><V><I><H><H><L><E><D><C><Q><Y><S><Q><A><L><K><K><V><F><A><Q><N><E><E><I><Q><E><M><A><Q><N><K><F><I><M><L><N><L><M><H><E><T><T><D><K... | Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.<BOP> | Q8TD06 |
Q96PI1 | SPRR4_HUMAN | Small proline-rich protein 4 | Homo | <M><S><S><Q><Q><Q><Q><R><Q><Q><Q><Q><C><P><P><Q><R><A><Q><Q><Q><Q><V><K><Q><P><C><Q><P><P><P><V><K><C><Q><E><T><C><A><P><K><T><K><D><P><C><A><P><Q><V><K><K><Q><C><P><P><K><G><T><I><I><P><A><Q><Q><K><C><P><S><A><Q><Q><A><S><K><S><K><Q><K> | Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.<BOP> | Q96PI1 |
Q9Y3D7 | TIM16_HUMAN | Presequence translocated-associated motor subunit PAM16 | Homo | <M><A><K><Y><L><A><Q><I><I><V><M><G><V><Q><V><V><G><R><A><F><A><R><A><L><R><Q><E><F><A><A><S><R><A><A><A><D><A><R><G><R><A><G><H><R><S><A><A><A><S><N><L><S><G><L><S><L><Q><E><A><Q><Q><I><L><N><V><S><K><L><S><P><E><E><V><Q><K><N><Y><E><H><L><F><K><V><N><D><K><S><V><G><G><S><F><Y><L><Q><S><K><V><V><R><A><K><E><R><L><D><E... | Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.<BOP> | Q9Y3D7 |
Q7RTT4 | SSX8_HUMAN | Putative protein SSX8 | Homo | <M><N><G><D><D><A><F><A><K><R><P><R><D><D><D><K><A><S><E><K><R><S><K><A><F><N><D><I><A><T><Y><F><S><K><K><E><W><E><K><M><K><Y><S><E><K><I><S><Y><V><Y><M><K><R><N><Y><E><A><M><T><K><L><G><F><N><V><T><L><P><P><F><M><C><N><K><Q><A><T><D><F><Q><G><N><Y><F><D><N><D><R><N><R><R><I><Q><V><E><R><P><Q><M><T><F><G><R><L><Q><R><I... | Could act as a modulator of transcription.<BOP> | Q7RTT4 |
Q9NSP4 | CENPM_HUMAN | Proliferation-associated nuclear element protein 1 | Homo | <M><S><V><L><R><P><L><D><K><L><P><G><L><N><T><A><T><I><L><L><V><G><T><E><D><A><L><L><Q><Q><L><A><D><S><M><L><K><E><D><C><A><S><E><L><K><V><H><L><A><K><S><L><P><L><P><S><S><V><N><R><P><R><I><D><L><I><V><F><V><V><N><L><H><S><K><Y><S><L><Q><N><T><E><E><S><L><R><H><V><D><A><S><F><F><L><G><K><V><C><F><L><A><T><G><A><G><R><E... | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA in... | Q9NSP4 |
P30532 | ACHA5_HUMAN | Neuronal acetylcholine receptor subunit alpha-5 | Homo | <M><A><A><R><G><S><G><P><R><A><L><R><L><L><L><L><V><Q><L><V><A><G><R><C><G><L><A><G><A><A><G><G><A><Q><R><G><L><S><E><P><S><S><I><A><K><H><E><D><S><L><L><K><D><L><F><Q><D><Y><E><R><W><V><R><P><V><E><H><L><N><D><K><I><K><I><K><F><G><L><A><I><S><Q><L><V><D><V><D><E><K><N><Q><L><M><T><T><N><V><W><L><K><Q><E><W><I><D><V><K... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | P30532 |
P10082 | PYY_HUMAN | PYY-II | Homo | <M><V><F><V><R><R><P><W><P><A><L><T><T><V><L><L><A><L><L><V><C><L><G><A><L><V><D><A><Y><P><I><K><P><E><A><P><R><E><D><A><S><P><E><E><L><N><R><Y><Y><A><S><L><R><H><Y><L><N><L><V><T><R><Q><R><Y><G><K><R><D><G><P><D><T><L><L><S><K><T><F><F><P><D><G><E><D><R><P><V><R><S><R><S><E><G><P><D><L><W> | This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.<BOP> | P10082 |
Q6ZR52 | ZN493_HUMAN | Zinc finger protein 493 | Homo | <M><N><E><C><N><V><H><K><E><G><Y><N><E><L><N><Q><Y><L><T><T><T><Q><S><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><L><L><N><S><N><R><H><N><T><K><H><T><G><K><K><P><F><K><C><K><K><C><G><K><S><F><C><M><L><L><H><L><C><Q><H><K><R><I><H><I><R><E><N><S><Y><R><C><E><E><C><G><K><A><F><I><W><F><S><T><L><T><R><H><R><R><V><H><T><G><E... | May be involved in transcriptional regulation.<BOP> | Q6ZR52 |
Q07001 | ACHD_HUMAN | Acetylcholine receptor subunit delta | Homo | <M><E><G><P><V><L><T><L><G><L><L><A><A><L><A><V><C><G><S><W><G><L><N><E><E><E><R><L><I><R><H><L><F><Q><E><K><G><Y><N><K><E><L><R><P><V><A><H><K><E><E><S><V><D><V><A><L><A><L><T><L><S><N><L><I><S><L><K><E><V><E><E><T><L><T><T><N><V><W><I><E><H><G><W><T><D><N><R><L><K><W><N><A><E><E><F><G><N><I><S><V><L><R><L><P><P><D><M... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | Q07001 |
Q9BZW5 | TM6S1_HUMAN | Transmembrane 6 superfamily member 1 | Homo | <M><S><A><S><A><A><T><G><V><F><V><L><S><L><S><A><I><P><V><T><Y><V><F><N><H><L><A><A><Q><H><D><S><W><T><I><V><G><V><A><A><L><I><L><F><L><V><A><L><L><A><R><V><L><V><K><R><K><P><P><R><D><P><L><F><Y><V><Y><A><V><F><G><F><T><S><V><V><N><L><I><I><G><L><E><Q><D><G><I><I><D><G><F><M><T><H><Y><L><R><E><G><E><P><Y><L><N><T><A><Y... | May function as sterol isomerase.<BOP> | Q9BZW5 |
Q86UD7 | TBC26_HUMAN | TBC1 domain family member 26 | Homo | <M><E><M><D><G><D><P><Y><N><L><P><A><Q><G><Q><G><N><I><I><I><T><K><Y><E><Q><G><H><R><A><G><A><A><V><D><L><G><H><E><Q><V><D><V><R><K><Y><T><N><N><L><G><I><V><H><E><M><E><L><P><H><V><S><A><L><E><V><K><Q><R><R><K><E><S><K><R><T><N><K><W><Q><K><M><L><A><D><W><T><K><Y><R><S><T><K><K><L><S><Q><R><V><Y><K><V><I><P><L><A><V><R... | May act as a GTPase-activating protein for Rab family protein(s).<BOP> | Q86UD7 |
Q2I0M5 | RSPO4_HUMAN | Roof plate-specific spondin-4 | Homo | <M><R><A><P><L><C><L><L><L><L><V><A><H><A><V><D><M><L><A><L><N><R><R><K><K><Q><V><G><T><G><L><G><G><N><C><T><G><C><I><I><C><S><E><E><N><G><C><S><T><C><Q><Q><R><L><F><L><F><I><R><R><E><G><I><R><Q><Y><G><K><C><L><H><D><C><P><P><G><Y><F><G><I><R><G><Q><E><V><N><R><C><K><K><C><G><A><T><C><E><S><C><F><S><Q><D><F><C><I><R><C... | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expres... | Q2I0M5 |
P20618 | PSB1_HUMAN | Proteasome gamma chain | Homo | <M><L><S><S><T><A><M><Y><S><A><P><G><R><D><L><G><M><E><P><H><R><A><A><G><P><L><Q><L><R><F><S><P><Y><V><F><N><G><G><T><I><L><A><I><A><G><E><D><F><A><I><V><A><S><D><T><R><L><S><E><G><F><S><I><H><T><R><D><S><P><K><C><Y><K><L><T><D><K><T><V><I><G><C><S><G><F><H><G><D><C><L><T><L><T><K><I><I><E><A><R><L><K><M><Y><K><H><S><N... | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and th... | P20618 |
P37023 | ACVL1_HUMAN | TGF-B superfamily receptor type I | Homo | <M><T><L><G><S><P><R><K><G><L><L><M><L><L><M><A><L><V><T><Q><G><D><P><V><K><P><S><R><G><P><L><V><T><C><T><C><E><S><P><H><C><K><G><P><T><C><R><G><A><W><C><T><V><V><L><V><R><E><E><G><R><H><P><Q><E><H><R><G><C><G><N><L><H><R><E><L><C><R><G><R><P><T><E><F><V><N><H><Y><C><C><D><S><H><L><C><N><H><N><V><S><L><V><L><E><A><T><Q... | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which aut... | P37023 |
Q96NG3 | ODAD4_HUMAN | Tetratricopeptide repeat protein 25 | Homo | <M><S><D><P><E><G><E><T><L><R><S><T><F><P><S><Y><M><A><E><G><E><R><L><Y><L><C><G><E><F><S><K><A><A><Q><S><F><S><N><A><L><Y><L><Q><D><G><D><K><N><C><L><V><A><R><S><K><C><F><L><K><M><G><D><L><E><R><S><L><K><D><A><E><A><S><L><Q><S><D><P><A><F><C><K><G><I><L><Q><K><A><E><T><L><Y><T><M><G><D><F><E><F><A><L><V><F><Y><H><R><G... | Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme.<BOP> | Q96NG3 |
P04216 | THY1_HUMAN | Thy-1 antigen | Homo | <M><N><L><A><I><S><I><A><L><L><L><T><V><L><Q><V><S><R><G><Q><K><V><T><S><L><T><A><C><L><V><D><Q><S><L><R><L><D><C><R><H><E><N><T><S><S><S><P><I><Q><Y><E><F><S><L><T><R><E><T><K><K><H><V><L><F><G><T><V><G><V><P><E><H><T><Y><R><S><R><T><N><F><T><S><K><Y><N><M><K><V><L><Y><L><S><A><F><T><S><K><D><E><G><T><Y><T><C><A><L><H... | May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.<BOP> | P04216 |
Q9Y2H8 | ZN510_HUMAN | Zinc finger protein 510 | Homo | <M><S><P><H><P><E><A><I><T><D><C><V><T><L><N><T><V><G><Q><L><A><E><G><G><Y><P><L><R><F><S><T><L><F><Q><E><Q><Q><K><M><N><I><S><Q><A><S><V><S><F><K><D><V><T><I><E><F><T><Q><E><E><W><Q><Q><M><A><P><V><Q><K><N><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><V><G><Y><C><C><F><K><P><E><V><I><F><K><L><E><Q><G><E><E><P><W><F><S... | May be involved in transcriptional regulation.<BOP> | Q9Y2H8 |
A6NNZ2 | TBB8B_HUMAN | Tubulin beta 8B | Homo | <M><R><E><I><V><L><T><Q><T><G><Q><C><G><N><Q><I><G><A><K><F><W><E><V><I><S><D><E><H><A><I><D><S><A><G><T><Y><H><G><D><S><H><L><Q><L><E><R><I><N><V><H><H><H><E><A><S><G><G><R><Y><V><P><R><A><V><L><V><D><L><E><P><G><T><M><D><S><V><H><S><G><P><F><G><Q><V><F><R><P><D><N><F><I><S><G><Q><C><G><A><G><N><N><W><A><K><G><R><Y><T... | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-... | A6NNZ2 |
Q70YC4 | TALAN_HUMAN | Talanin | Homo | <M><S><A><L><G><Q><I><T><I><T><V><S><R><C><W><N><T><E><R><N><Q><T><D><K><N><P><C><L><H><G><A><Y><L><Q><L><R><E><T><V><K><N><K><S><T><H><L><K><K><P><L><M><K><Q><A><P><P><W><K><D><H><L><T><F><Q><P><L><H><P><A><E><R><K><T><Q><V><W><R><W><Q><S><G><N><S><S><D><L><E><T><T><S><S><A><S><P><W><P><T><G><S><N><R><D><V><V><L><N><T... | May play a role in uric acid excretion.<BOP> | Q70YC4 |
Q9NUX5 | POTE1_HUMAN | POT1-like telomere end-binding protein | Homo | <M><S><L><V><P><A><T><N><Y><I><Y><T><P><L><N><Q><L><K><G><G><T><I><V><N><V><Y><G><V><V><K><F><F><K><P><P><Y><L><S><K><G><T><D><Y><C><S><V><V><T><I><V><D><Q><T><N><V><K><L><T><C><L><L><F><S><G><N><Y><E><A><L><P><I><I><Y><K><N><G><D><I><V><R><F><H><R><L><K><I><Q><V><Y><K><K><E><T><Q><G><I><T><S><S><G><F><A><S><L><T><F><E... | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomer... | Q9NUX5 |
Q15270 | NKX11_HUMAN | NKX-1.1 | Homo | <M><S><A><S><G><P><E><A><P><G><D><I><P><A><L><P><P><P><P><Q><P><G><S><G><P><A><P><P><A><P><A><A><A><A><Q><E><A><M><D><G><R><A><E><L><P><A><F><P><R><A><G><A><P><P><L><A><A><S><D><T><V><P><A><A><P><E><G><A><G><A><A><R><P><A><A><P><L><R><P><T><S><F><S><V><L><D><I><L><D><P><N><K><F><N><S><R><R><R><R><C><V><L><L><G><P><V><A... | May be required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly by regulating the transcription of specific factors involved in energy balance.<BOP> | Q15270 |
Q9UBF9 | MYOTI_HUMAN | Titin immunoglobulin domain protein | Homo | <M><F><N><Y><E><R><P><K><H><F><I><Q><S><Q><N><P><C><G><S><R><L><Q><P><P><G><P><E><T><S><S><F><S><S><Q><T><K><Q><S><S><I><I><I><Q><P><R><Q><C><T><E><Q><R><F><S><A><S><S><T><L><S><S><H><I><T><M><S><S><S><A><F><P><A><S><P><K><Q><H><A><G><S><N><P><G><Q><R><V><T><T><T><Y><N><Q><S><P><A><S><F><L><S><S><I><L><P><S><Q><P><D><Y... | Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells.<BOP> | Q9UBF9 |
P16104 | H2AX_HUMAN | Histone H2A.X | Homo | <M><S><G><R><G><K><T><G><G><K><A><R><A><K><A><K><S><R><S><S><R><A><G><L><Q><F><P><V><G><R><V><H><R><L><L><R><K><G><H><Y><A><E><R><V><G><A><G><A><P><V><Y><L><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><T><R><I><I><P><R><H><L><Q><L><A><I><R><N><D><E><E><L><N><K><L><L><G><G><V><T><I><A><Q><G><G... | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chrom... | P16104 |
Q86WN1 | FCSD1_HUMAN | Protein nervous wreck 2 | Homo | <M><Q><P><P><P><R><K><V><K><P><A><Q><E><V><K><L><R><F><L><E><Q><L><S><I><L><Q><T><W><Q><Q><R><E><A><D><L><L><E><D><I><R><S><Y><S><K><Q><R><A><A><I><E><R><E><Y><G><Q><A><L><Q><K><L><A><G><P><F><L><K><R><E><G><H><R><S><G><E><M><D><S><R><G><R><T><V><F><G><A><W><R><C><L><L><D><A><T><V><A><G><G><Q><T><R><L><Q><A><S><D><R><Y... | Promotes actin polymerization mediated by SNX9 and WASL.<BOP> | Q86WN1 |
Q9P209 | CEP72_HUMAN | Centrosomal protein of 72 kDa | Homo | <M><A><R><A><G><P><R><L><V><L><S><E><E><A><V><R><A><K><S><G><L><G><P><H><R><D><L><A><E><L><Q><S><L><S><I><P><G><T><Y><Q><E><K><I><T><H><L><G><H><S><L><M><S><L><T><G><L><K><S><L><D><L><S><R><N><S><L><V><S><L><E><G><I><Q><Y><L><T><A><L><E><S><L><N><L><Y><Y><N><C><I><S><S><L><A><E><V><F><R><L><H><A><L><T><E><L><V><D><V><D... | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required... | Q9P209 |
Q969W0 | SPTSA_HUMAN | Small subunit of serine palmitoyltransferase A | Homo | <M><A><G><M><A><L><A><R><A><W><K><Q><M><S><W><F><Y><Y><Q><Y><L><L><V><T><A><L><Y><M><L><E><P><W><E><R><T><V><F><N><S><M><L><V><S><I><V><G><M><A><L><Y><T><G><Y><V><F><M><P><Q><H><I><M><A><I><L><H><Y><F><E><I><V><Q> | Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as su... | Q969W0 |
Q9NPI0 | TM138_HUMAN | Transmembrane protein 138 | Homo | <M><L><Q><T><S><N><Y><S><L><V><L><S><L><Q><F><L><L><L><S><Y><D><L><F><V><N><S><F><S><E><L><L><Q><K><T><P><V><I><Q><L><V><L><F><I><I><Q><D><I><A><V><L><F><N><I><I><I><I><F><L><M><F><F><N><T><F><V><F><Q><A><G><L><V><N><L><L><F><H><K><F><K><G><T><I><I><L><T><A><V><Y><F><A><L><S><I><S><L><H><V><W><V><M><N><L><R><W><K><N><S... | Required for ciliogenesis.<BOP> | Q9NPI0 |
Q8TAD2 | IL17D_HUMAN | Interleukin-27 | Homo | <M><L><V><A><G><F><L><L><A><L><P><P><S><W><A><A><G><A><P><R><A><G><R><R><P><A><R><P><R><G><C><A><D><R><P><E><E><L><L><E><Q><L><Y><G><R><L><A><A><G><V><L><S><A><F><H><H><T><L><Q><L><G><P><R><E><Q><A><R><N><A><S><C><P><A><G><G><R><P><A><D><R><R><F><R><P><P><T><N><L><R><S><V><S><P><W><A><Y><R><I><S><Y><D><P><A><R><Y><P><R... | Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.<BOP> | Q8TAD2 |
P0CW23 | AKAI1_HUMAN | A-kinase anchor protein inhibitor 1 | Homo | <M><V><F><A><P><G><E><K><P><G><N><E><P><E><E><V><K><L><Q><N><A><S><K><Q><I><V><Q><N><A><I><L><Q><A><V><Q><Q><V><S><Q><E><S><Q><R><R><E><E><R><I><S><D><N><R><D><H><I><Q><L><G><V><G><E><L><T><K><K><H><E><K><K> | Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA .<BOP> | P0CW23 |
Q9H9K5 | MER34_HUMAN | Endogenous retroviral envelope protein HEMO, 48 kDa form | Homo | <M><G><S><L><S><N><Y><A><L><L><Q><L><T><L><T><A><F><L><T><I><L><V><Q><P><Q><H><L><L><A><P><V><F><R><T><L><S><I><L><T><N><Q><S><N><C><W><L><C><E><H><L><D><N><A><E><Q><P><E><L><V><F><V><P><A><S><A><S><T><W><W><T><Y><S><G><Q><W><M><Y><E><R><V><W><Y><P><Q><A><E><V><Q><N><H><S><T><S><S><Y><R><K><V><T><W><H><W><E><A><S><M><E... | Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.<BOP> | Q9H9K5 |
Q13651 | I10R1_HUMAN | Interleukin-10 receptor subunit 1 | Homo | <M><L><P><C><L><V><V><L><L><A><A><L><L><S><L><R><L><G><S><D><A><H><G><T><E><L><P><S><P><P><S><V><W><F><E><A><E><F><F><H><H><I><L><H><W><T><P><I><P><N><Q><S><E><S><T><C><Y><E><V><A><L><L><R><Y><G><I><E><S><W><N><S><I><S><N><C><S><Q><T><L><S><Y><D><L><T><A><V><T><L><D><L><Y><H><S><N><G><Y><R><A><R><V><R><A><V><D><G><S><R... | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well . In turn, the heterotetrameric assembly complex,... | Q13651 |
P17039 | ZNF30_HUMAN | Zinc finger protein KOX28 | Homo | <M><A><H><K><Y><V><G><L><Q><Y><H><G><S><V><T><F><E><D><V><A><I><A><F><S><Q><Q><E><W><E><S><L><D><S><S><Q><R><G><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><M><G><H><S><R><S><K><P><H><V><I><A><L><L><E><Q><W><K><E><P><E><V><T><V><R><K><D><G><R><R><W><C><T><D><L><Q><L><E><D><D><T><I><G><C><K><E><M><P><T><S><E><N><C><P><S... | May be involved in transcriptional regulation.<BOP> | P17039 |
P55040 | GEM_HUMAN | RAS-like protein KIR | Homo | <M><T><L><N><N><V><T><M><R><Q><G><T><V><G><M><Q><P><Q><Q><Q><R><W><S><I><P><A><D><G><R><H><L><M><V><Q><K><E><P><H><Q><Y><S><H><R><N><R><H><S><A><T><P><E><D><H><C><R><R><S><W><S><S><D><S><T><D><S><V><I><S><S><E><S><G><N><T><Y><Y><R><V><V><L><I><G><E><Q><G><V><G><K><S><T><L><A><N><I><F><A><G><V><H><D><S><M><D><S><D><C><E... | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.<BOP> | P55040 |
P15289 | ARSA_HUMAN | Arylsulfatase A component C | Homo | <M><G><A><P><R><S><L><L><L><A><L><A><A><G><L><A><V><A><R><P><P><N><I><V><L><I><F><A><D><D><L><G><Y><G><D><L><G><C><Y><G><H><P><S><S><T><T><P><N><L><D><Q><L><A><A><G><G><L><R><F><T><D><F><Y><V><P><V><S><L><C><T><P><S><R><A><A><L><L><T><G><R><L><P><V><R><M><G><M><Y><P><G><V><L><V><P><S><S><R><G><G><L><P><L><E><E><V><T><V... | Hydrolyzes cerebroside sulfate.<BOP> | P15289 |
Q32NB8 | PGPS1_HUMAN | Phosphatidylglycerophosphate synthase 1 | Homo | <M><A><V><A><A><A><A><A><A><G><P><V><F><W><R><R><L><L><G><L><L><P><G><R><P><G><L><A><A><L><L><G><R><L><S><D><R><L><G><R><N><R><D><R><Q><R><R><R><S><P><W><L><L><L><A><P><L><L><S><P><A><V><P><Q><V><T><S><P><P><C><C><L><C><P><E><G><V><H><R><F><Q><W><I><R><N><L><V><P><E><F><G><V><S><S><S><H><V><R><V><L><S><S><P><A><E><F><F... | Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.<BOP> | Q32NB8 |
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