accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q9UJ14 | GGT7_HUMAN | Glutathione hydrolase 7 light chain | Homo | <M><A><A><E><N><E><A><S><Q><E><S><A><L><G><A><Y><S><P><V><D><Y><M><S><I><T><S><F><P><R><L><P><E><D><E><P><A><P><A><A><P><L><R><G><R><K><D><E><D><A><F><L><G><D><P><D><T><D><P><D><S><F><L><K><S><A><R><L><Q><R><L><P><S><S><S><S><E><M><G><S><Q><D><G><S><P><L><R><E><T><R><K><D><P><F><S><A><A><A><A><E><C><S><C><R><Q><D><G><L><T><V><I><V><T><A><C><L><T><F><A><T><G><V><T><V><A><L><V><M><Q><I><Y><F><G><D><P><Q><I><F><Q><Q><G><A><V><V><T><D><A><A><R><C><T><S><L><G><I><E><V><L><S><K><Q><G><S><S><V><D><A><A><V><A><A><A><L><C><L><G><I><V><A><P><H><S><S><G><L><G><G><G><G><V><M><L><V><H><D><I><R><R><N><E><S><H><L><I><D><F><R><E><S><A><P><G><A><L><R><E><E><T><L><Q><R><S><W><E><T><K><P><G><L><L><V><G><V><P><G><M><V><K><G><L><H><E><A><H><Q><L><Y><G><R><L><P><W><S><Q><V><L><A><F><A><A><A><V><A><Q><D><G><F><N><V><T><H><D><L><A><R><A><L><A><E><Q><L><P><P><N><M><S><E><R><F><R><E><T><F><L><P><S><G><R><P><P><L><P><G><S><L><L><H><R><P><D><L><A><E><V><L><D><V><L><G><T><S><G><P><A><A><F><Y><A><G><G><N><L><T><L><E><M><V><A><E><A><Q><H><A><G><G><V><I><T><E><E><D><F><S><N><Y><S><A><L><V><E><K><P><V><C><G><V><Y><R><G><H><L><V><L><S><P><P><P><P><H><T><G><P><A><L><I><S><A><L><N><I><L><E><G><F><N><L><T><S><L><V><S><R><E><Q><A><L><H><W><V><A><E><T><L><K><I><A><L><A><L><A><S><R><L><G><D><P><V><Y><D><S><T><I><T><E><S><M><D><D><M><L><S><K><V><E><A><A><Y><L><R><G><H><I><N><D><S><Q><A><A><P><A><P><L><L><P><V><Y><E><L><D><G><A><P><T><A><A><Q><V><L><I><M><G><P><D><D><F><I><V><A><M><V><S><S><L><N><Q><P><F><G><S><G><L><I><T><P><S><G><I><L><L><N><S><Q><M><L><D><F><S><W><P><N><R><T><A><N><H><S><A><P><S><L><E><N><S><V><Q><P><G><K><R><P><L><S><F><L><L><P><T><V><V><R><P><A><E><G><L><C><G><T><Y><L><A><L><G><A><N><G><A><A><R><G><L><S><G><L><T><Q><V><L><L><N><V><L><T><L><N><R><N><L><S><D><S><L><A><R><G><R><L><H><P><D><L><Q><S><N><L><L><Q><V><D><S><E><F><T><E><E><E><I><E><F><L><E><A><R><G><H><H><V><E><K><V><D><V><L><S><W><V><H><G><S><R><R><T><N><N><F><I><I><A><V><K><D><P><R><S><P><D><A><A><G><A><T><I><L> | Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.<BOP> | Q9UJ14 |
O00472 | ELL2_HUMAN | RNA polymerase II elongation factor ELL2 | Homo | <M><A><A><G><G><T><G><G><L><R><E><E><Q><R><Y><G><L><S><C><G><R><L><G><Q><D><N><I><T><V><L><H><V><K><L><T><E><T><A><I><R><A><L><E><T><Y><Q><S><H><K><N><L><I><P><F><R><P><S><I><Q><F><Q><G><L><H><G><L><V><K><I><P><K><N><D><P><L><N><E><V><H><N><F><N><F><Y><L><S><N><V><G><K><D><N><P><Q><G><S><F><D><C><I><Q><Q><T><F><S><S><S><G><A><S><Q><L><N><C><L><G><F><I><Q><D><K><I><T><V><C><A><T><N><D><S><Y><Q><M><T><R><E><R><M><T><Q><A><E><E><E><S><R><N><R><S><T><K><V><I><K><P><G><G><P><Y><V><G><K><R><V><Q><I><R><K><A><P><Q><A><V><S><D><T><V><P><E><R><K><R><S><T><P><M><N><P><A><N><T><I><R><K><T><H><S><S><S><T><I><S><Q><R><P><Y><R><D><R><V><I><H><L><L><A><L><K><A><Y><K><K><P><E><L><L><A><R><L><Q><K><D><G><V><N><Q><K><D><K><N><S><L><G><A><I><L><Q><Q><V><A><N><L><N><S><K><D><L><S><Y><T><L><K><D><Y><V><F><K><E><L><Q><R><D><W><P><G><Y><S><E><I><D><R><R><S><L><E><S><V><L><S><R><K><L><N><P><S><Q><N><A><A><G><T><S><R><S><E><S><P><V><C><S><S><R><D><A><V><S><S><P><Q><K><R><L><L><D><S><E><F><I><D><P><L><M><N><K><K><A><R><I><S><H><L><T><N><R><V><P><P><T><L><N><G><H><L><N><P><T><S><E><K><S><A><A><G><L><P><L><P><P><A><A><A><A><I><P><T><P><P><P><L><P><S><T><Y><L><P><I><S><H><P><P><Q><I><V><N><S><N><S><N><S><P><S><T><P><E><G><R><G><T><Q><D><L><P><V><D><S><F><S><Q><N><D><S><I><Y><E><D><Q><Q><D><K><Y><T><S><R><T><S><L><E><T><L><P><P><G><S><V><L><L><K><C><P><K><P><M><E><E><N><H><S><M><S><H><K><K><S><K><K><K><S><K><K><H><K><E><K><D><Q><I><K><K><H><D><I><E><T><I><E><E><K><E><E><D><L><K><R><E><E><E><I><A><K><L><N><N><S><S><P><N><S><S><G><G><V><K><E><D><C><T><A><S><M><E><P><S><A><I><E><L><P><D><Y><L><I><K><Y><I><A><I><V><S><Y><E><Q><R><Q><N><Y><K><D><D><F><N><A><E><Y><D><E><Y><R><A><L><H><A><R><M><E><T><V><A><R><R><F><I><K><L><D><A><Q><R><K><R><L><S><P><G><S><K><E><Y><Q><N><V><H><E><E><V><L><Q><E><Y><Q><K><I><K><Q><S><S><P><N><Y><H><E><E><K><Y><R><C><E><Y><L><H><N><K><L><A><H><I><K><R><L><I><G><E><F><D><Q><Q><Q><A><E><S><W><S> | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III . Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<BOP> | O00472 |
Q8N1W2 | ZN710_HUMAN | Zinc finger protein 710 | Homo | <M><E><G><F><M><D><S><G><T><Q><T><D><A><V><V><V><L><S><L><A><Q><A><A><V><L><G><L><V><S><E><N><E><L><F><G><A><T><I><S><A><E><A><F><Y><P><D><L><G><P><E><L><S><G><A><A><M><G><E><P><E><P><P><G><P><D><V><Y><Q><L><A><C><N><G><R><A><L><E><E><P><A><E><E><E><V><L><E><V><E><A><A><C><E><K><H><T><R><R><K><T><R><P><P><V><R><L><V><P><K><V><K><F><E><K><V><E><E><E><E><Q><E><V><Y><E><V><S><V><P><G><D><D><K><D><A><G><P><A><E><A><P><A><E><A><A><S><G><G><C><D><A><L><V><Q><S><S><A><V><K><M><I><D><L><S><A><F><S><R><K><P><R><T><L><R><H><L><P><R><T><P><R><P><E><L><N><V><A><P><Y><D><P><H><F><P><A><P><A><R><D><G><F><P><E><P><S><M><A><L><P><G><P><E><A><L><P><T><E><C><G><F><E><P><P><H><L><A><P><L><S><D><P><E><A><P><S><M><E><S><P><E><P><V><K><P><E><Q><G><F><V><W><Q><E><A><S><E><F><E><A><D><T><A><G><S><T><V><E><R><H><K><K><A><Q><L><D><R><L><D><I><N><V><Q><I><D><D><S><Y><L><V><E><A><G><D><R><Q><K><R><W><Q><C><R><M><C><E><K><S><Y><T><S><K><Y><N><L><V><T><H><I><L><G><H><N><G><I><K><P><H><S><C><P><H><C><S><K><L><F><K><Q><P><S><H><L><Q><T><H><L><L><T><H><Q><G><T><R><P><H><K><C><Q><V><C><H><K><A><F><T><Q><T><S><H><L><K><R><H><M><L><L><H><S><E><V><K><P><Y><S><C><H><F><C><G><R><G><F><A><Y><P><S><E><L><K><A><H><E><V><K><H><E><S><G><R><C><H><V><C><V><E><C><G><L><D><F><S><T><L><T><Q><L><K><R><H><L><A><S><H><Q><G><P><T><L><Y><Q><C><L><E><C><D><K><S><F><H><Y><R><S><Q><L><Q><N><H><M><L><K><H><Q><N><V><R><P><F><V><C><T><E><C><G><M><E><F><S><Q><I><H><H><L><K><Q><H><S><L><T><H><K><G><V><K><E><F><K><C><E><V><C><G><R><E><F><T><L><Q><A><N><M><K><R><H><M><L><I><H><T><S><V><R><P><Y><Q><C><H><I><C><F><K><T><F><V><Q><K><Q><T><L><K><T><H><M><I><V><H><S><P><V><K><P><F><K><C><K><V><C><G><K><S><F><N><R><M><Y><N><L><L><G><H><M><H><L><H><A><G><S><K><P><F><K><C><P><Y><C><S><S><K><F><N><L><K><G><N><L><S><R><H><M><K><V><K><H><G><V><M><D><I><G><L><D><S><Q><D><P><M><M><E><L><T><G><T><D><P><S><E><L><D><G><Q><Q><E><M><E><D><F><E><E><N><A><Y><S><Y><A><S><V><D><S><S><A><E><A><S><V><L><T><E><Q><A><M><K><E><M><A><Y><Y><N><V><L> | May be involved in transcriptional regulation.<BOP> | Q8N1W2 |
Q9H788 | SH24A_HUMAN | Protein phosphatase 1 regulatory subunit 38 | Homo | <M><L><K><Q><I><L><S><E><M><Y><I><D><P><D><L><L><A><E><L><S><E><E><Q><K><Q><I><L><F><F><K><M><R><E><E><Q><I><R><R><W><K><E><R><E><A><A><M><E><R><K><E><S><L><P><V><K><P><R><P><K><K><E><N><G><K><S><V><H><W><K><L><G><A><D><K><E><V><W><V><W><V><M><G><E><H><H><L><D><K><P><Y><D><V><L><C><N><E><I><I><A><E><R><A><R><L><K><A><E><Q><E><A><E><E><P><R><K><T><H><S><E><E><F><T><N><S><L><K><T><K><S><Q><Y><H><D><L><Q><A><P><D><N><Q><Q><T><K><D><I><W><K><K><V><A><E><K><E><E><L><E><Q><G><S><R><P><A><P><T><L><E><E><E><K><I><R><S><L><S><S><S><S><R><N><I><Q><Q><M><L><A><D><S><I><N><R><M><K><A><Y><A><F><H><Q><K><K><E><S><M><K><K><K><Q><D><E><E><I><N><Q><I><E><E><E><R><T><K><Q><I><C><K><S><W><K><E><D><S><E><W><Q><A><S><L><R><K><S><K><A><A><D><E><K><R><R><S><L><A><K><Q><A><R><E><D><Y><K><R><L><S><L><G><A><Q><K><G><R><G><G><E><R><L><Q><S><P><L><R><V><P><Q><K><P><E><R><P><P><L><P><P><K><P><Q><F><L><N><S><G><A><Y><P><Q><K><P><L><R><N><Q><G><V><V><R><T><L><S><S><S><A><Q><E><D><I><I><R><W><F><K><E><E><Q><L><P><L><R><A><G><Y><Q><K><T><S><D><T><I><A><P><W><F><H><G><I><L><T><L><K><K><A><N><E><L><L><L><S><T><G><M><P><G><S><F><L><I><R><V><S><E><R><I><K><G><Y><A><L><S><Y><L><S><E><D><G><C><K><H><F><L><I><D><A><S><A><D><A><Y><S><F><L><G><V><D><Q><L><Q><H><A><T><L><A><D><L><V><E><Y><H><K><E><E><P><I><T><S><L><G><K><E><L><L><L><Y><P><C><G><Q><Q><D><Q><L><P><D><Y><L><E><L><F><E> | Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.<BOP> | Q9H788 |
P42330 | AK1C3_HUMAN | Testosterone 17-beta-dehydrogenase 5 | Homo | <M><D><S><K><H><Q><C><V><K><L><N><D><G><H><F><M><P><V><L><G><F><G><T><Y><A><P><P><E><V><P><R><S><K><A><L><E><V><T><K><L><A><I><E><A><G><F><R><H><I><D><S><A><H><L><Y><N><N><E><E><Q><V><G><L><A><I><R><S><K><I><A><D><G><S><V><K><R><E><D><I><F><Y><T><S><K><L><W><S><T><F><H><R><P><E><L><V><R><P><A><L><E><N><S><L><K><K><A><Q><L><D><Y><V><D><L><Y><L><I><H><S><P><M><S><L><K><P><G><E><E><L><S><P><T><D><E><N><G><K><V><I><F><D><I><V><D><L><C><T><T><W><E><A><M><E><K><C><K><D><A><G><L><A><K><S><I><G><V><S><N><F><N><R><R><Q><L><E><M><I><L><N><K><P><G><L><K><Y><K><P><V><C><N><Q><V><E><C><H><P><Y><F><N><R><S><K><L><L><D><F><C><K><S><K><D><I><V><L><V><A><Y><S><A><L><G><S><Q><R><D><K><R><W><V><D><P><N><S><P><V><L><L><E><D><P><V><L><C><A><L><A><K><K><H><K><R><T><P><A><L><I><A><L><R><Y><Q><L><Q><R><G><V><V><V><L><A><K><S><Y><N><E><Q><R><I><R><Q><N><V><Q><V><F><E><F><Q><L><T><A><E><D><M><K><A><I><D><G><L><D><R><N><L><H><Y><F><N><S><D><S><F><A><S><H><P><N><Y><P><Y><S><D><E><Y> | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone . Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH . Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone . Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol . Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha | P42330 |
O75030 | MITF_HUMAN | Class E basic helix-loop-helix protein 32 | Homo | <M><Q><S><E><S><G><I><V><P><D><F><E><V><G><E><E><F><H><E><E><P><K><T><Y><Y><E><L><K><S><Q><P><L><K><S><S><S><S><A><E><H><P><G><A><S><K><P><P><I><S><S><S><S><M><T><S><R><I><L><L><R><Q><Q><L><M><R><E><Q><M><Q><E><Q><E><R><R><E><Q><Q><Q><K><L><Q><A><A><Q><F><M><Q><Q><R><V><P><V><S><Q><T><P><A><I><N><V><S><V><P><T><T><L><P><S><A><T><Q><V><P><M><E><V><L><K><V><Q><T><H><L><E><N><P><T><K><Y><H><I><Q><Q><A><Q><R><Q><Q><V><K><Q><Y><L><S><T><T><L><A><N><K><H><A><N><Q><V><L><S><L><P><C><P><N><Q><P><G><D><H><V><M><P><P><V><P><G><S><S><A><P><N><S><P><M><A><M><L><T><L><N><S><N><C><E><K><E><G><F><Y><K><F><E><E><Q><N><R><A><E><S><E><C><P><G><M><N><T><H><S><R><A><S><C><M><Q><M><D><D><V><I><D><D><I><I><S><L><E><S><S><Y><N><E><E><I><L><G><L><M><D><P><A><L><Q><M><A><N><T><L><P><V><S><G><N><L><I><D><L><Y><G><N><Q><G><L><P><P><P><G><L><T><I><S><N><S><C><P><A><N><L><P><N><I><K><R><E><L><T><A><C><I><F><P><T><E><S><E><A><R><A><L><A><K><E><R><Q><K><K><D><N><H><N><L><I><E><R><R><R><R><F><N><I><N><D><R><I><K><E><L><G><T><L><I><P><K><S><N><D><P><D><M><R><W><N><K><G><T><I><L><K><A><S><V><D><Y><I><R><K><L><Q><R><E><Q><Q><R><A><K><E><L><E><N><R><Q><K><K><L><E><H><A><N><R><H><L><L><L><R><I><Q><E><L><E><M><Q><A><R><A><H><G><L><S><L><I><P><S><T><G><L><C><S><P><D><L><V><N><R><I><I><K><Q><E><P><V><L><E><N><C><S><Q><D><L><L><Q><H><H><A><D><L><T><C><T><T><T><L><D><L><T><D><G><T><I><T><F><N><N><N><L><G><T><G><T><E><A><N><Q><A><Y><S><V><P><T><K><M><G><S><K><L><E><D><I><L><M><D><D><T><L><S><P><V><G><V><T><D><P><L><L><S><S><V><S><P><G><A><S><K><T><S><S><R><R><S><S><M><S><M><E><E><T><E><H><T><C> | Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.<BOP> | O75030 |
Q9H3M7 | TXNIP_HUMAN | Vitamin D3 up-regulated protein 1 | Homo | <M><V><M><F><K><K><I><K><S><F><E><V><V><F><N><D><P><E><K><V><Y><G><S><G><E><K><V><A><G><R><V><I><V><E><V><C><E><V><T><R><V><K><A><V><R><I><L><A><C><G><V><A><K><V><L><W><M><Q><G><S><Q><Q><C><K><Q><T><S><E><Y><L><R><Y><E><D><T><L><L><L><E><D><Q><P><T><G><E><N><E><M><V><I><M><R><P><G><N><K><Y><E><Y><K><F><G><F><E><L><P><Q><G><P><L><G><T><S><F><K><G><K><Y><G><C><V><D><Y><W><V><K><A><F><L><D><R><P><S><Q><P><T><Q><E><T><K><K><N><F><E><V><V><D><L><V><D><V><N><T><P><D><L><M><A><P><V><S><A><K><K><E><K><K><V><S><C><M><F><I><P><D><G><R><V><S><V><S><A><R><I><D><R><K><G><F><C><E><G><D><E><I><S><I><H><A><D><F><E><N><T><C><S><R><I><V><V><P><K><A><A><I><V><A><R><H><T><Y><L><A><N><G><Q><T><K><V><L><T><Q><K><L><S><S><V><R><G><N><H><I><I><S><G><T><C><A><S><W><R><G><K><S><L><R><V><Q><K><I><R><P><S><I><L><G><C><N><I><L><R><V><E><Y><S><L><L><I><Y><V><S><V><P><G><S><K><K><V><I><L><D><L><P><L><V><I><G><S><R><S><G><L><S><S><R><T><S><S><M><A><S><R><T><S><S><E><M><S><W><V><D><L><N><I><P><D><T><P><E><A><P><P><C><Y><M><D><V><I><P><E><D><H><R><L><E><S><P><T><T><P><L><L><D><D><M><D><G><S><Q><D><S><P><I><F><M><Y><A><P><E><F><K><F><M><P><P><P><T><Y><T><E><V><D><P><C><I><L><N><N><N><V><Q> | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).<BOP> | Q9H3M7 |
Q5JUX0 | SPIN3_HUMAN | Spindlin-like protein 3 | Homo | <M><K><T><P><F><G><K><A><A><A><G><Q><R><S><R><T><G><A><G><H><G><S><V><S><V><T><M><I><K><R><K><A><A><H><K><K><H><R><S><R><P><T><S><Q><P><R><G><N><I><V><G><C><R><I><Q><H><G><W><K><D><G><D><E><P><L><T><Q><W><K><G><T><V><L><D><Q><V><P><V><N><P><S><L><Y><L><I><K><Y><D><G><F><D><C><V><Y><G><L><E><L><H><R><D><E><R><V><S><S><L><E><V><L><P><N><R><V><A><S><S><R><I><S><D><T><H><L><A><E><I><M><V><G><K><A><V><E><H><I><F><E><T><E><E><G><S><K><N><E><W><R><G><M><V><L><A><Q><A><P><V><M><N><T><W><F><Y><I><T><Y><E><K><D><P><V><L><Y><M><Y><Q><L><L><D><D><Y><K><D><G><D><L><R><I><L><Q><D><S><N><D><S><P><L><A><E><R><E><P><G><E><V><I><D><S><L><V><G><K><Q><V><E><Y><A><K><D><D><G><S><K><R><T><G><M><V><I><H><Q><V><E><A><K><P><S><V><Y><F><I><K><F><D><D><D><F><H><I><Y><V><Y><D><L><V><K><T><S> | Exhibits H3K4me3-binding activity.<BOP> | Q5JUX0 |
Q8NHP6 | MSPD2_HUMAN | Motile sperm domain-containing protein 2 | Homo | <M><A><E><N><H><A><Q><N><K><A><K><L><I><S><E><T><R><R><R><F><E><A><E><Y><V><T><D><K><S><D><K><Y><D><A><R><D><V><E><R><L><Q><Q><D><D><N><W><V><E><S><Y><L><S><W><R><H><N><I><V><D><E><T><L><K><M><L><D><E><S><F><Q><W><R><K><E><I><S><V><N><D><L><N><E><S><S><I><P><R><W><L><L><E><I><G><V><I><Y><L><H><G><Y><D><K><E><G><N><K><L><F><W><I><R><V><K><Y><H><V><K><D><Q><K><T><I><L><D><K><K><K><L><I><A><F><W><L><E><R><Y><A><K><R><E><N><G><K><P><V><T><V><M><F><D><L><S><E><T><G><I><N><S><I><D><M><D><F><V><R><F><I><I><N><C><F><K><V><Y><Y><P><K><Y><L><S><K><I><V><I><F><D><M><P><W><L><M><N><A><A><F><K><I><V><K><T><W><L><G><P><E><A><V><S><L><L><K><F><T><S><K><N><E><V><Q><D><Y><V><S><V><E><Y><L><P><P><H><M><G><G><T><D><P><F><K><Y><S><Y><P><P><L><V><D><D><D><F><Q><T><P><L><C><E><N><G><P><I><T><S><E><D><E><T><S><S><K><E><D><I><E><S><D><G><K><E><T><L><E><T><I><S><N><E><E><Q><T><P><L><L><K><K><I><N><P><T><E><S><T><S><K><A><E><E><N><E><K><V><D><S><K><V><K><A><F><K><K><P><L><S><V><F><K><G><P><L><L><H><I><S><P><A><E><E><L><Y><F><G><S><T><E><S><G><E><K><K><T><L><I><V><L><T><N><V><T><K><N><I><V><A><F><K><V><R><T><T><A><P><E><K><Y><R><V><K><P><S><N><S><S><C><D><P><G><A><S><V><D><I><V><V><S><P><H><G><G><L><T><V><S><A><Q><D><R><F><L><I><M><A><A><E><M><E><Q><S><S><G><T><G><P><A><E><L><T><Q><F><W><K><E><V><P><R><N><K><V><M><E><H><R><L><R><C><H><T><V><E><S><S><K><P><N><T><L><T><L><K><D><N><A><F><N><M><S><D><K><T><S><E><D><I><C><L><Q><L><S><R><L><L><E><S><N><R><K><L><E><D><Q><V><Q><R><C><I><W><F><Q><Q><L><L><L><S><L><T><M><L><L><L><A><F><V><T><S><F><F><Y><L><L><Y><S> | Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif . Might have a more important role in endoplasmic reticulum and endosomes contacts . Promotes migration of primary monocytes and neutrophils, in response to various chemokines .<BOP> | Q8NHP6 |
Q2I0M4 | LRC26_HUMAN | Cytokeratin-associated protein in cancer | Homo | <M><R><G><P><S><W><S><R><P><R><P><L><L><L><L><L><L><L><L><S><P><W><P><V><W><A><Q><V><S><A><T><A><S><P><S><G><S><L><G><A><P><D><C><P><E><V><C><T><C><V><P><G><G><L><A><S><C><S><A><L><S><L><P><A><V><P><P><G><L><S><L><R><L><R><A><L><L><L><D><H><N><R><V><R><A><L><P><P><G><A><F><A><G><A><G><A><L><Q><R><L><D><L><R><E><N><G><L><H><S><V><H><V><R><A><F><W><G><L><G><A><L><Q><L><L><D><L><S><A><N><Q><L><E><A><L><A><P><G><T><F><A><P><L><R><A><L><R><N><L><S><L><A><G><N><R><L><A><R><L><E><P><A><A><L><G><A><L><P><L><L><R><S><L><S><L><Q><D><N><E><L><A><A><L><A><P><G><L><L><G><R><L><P><A><L><D><A><L><H><L><R><G><N><P><W><G><C><G><C><A><L><R><P><L><C><A><W><L><R><R><H><P><L><P><A><S><E><A><E><T><V><L><C><V><W><P><G><R><L><T><L><S><P><L><T><A><F><S><D><A><A><F><S><H><C><A><Q><P><L><A><L><R><D><L><A><V><V><Y><T><L><G><P><A><S><F><L><V><S><L><A><S><C><L><A><L><G><S><G><L><T><A><C><R><A><R><R><R><R><L><R><T><A><A><L><R><P><P><R><P><P><D><P><N><P><D><P><D><P><H><G><C><A><S><P><A><D><P><G><S><P><A><A><A><A><Q><A> | Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.<BOP> | Q2I0M4 |
Q9H4K1 | RIBC2_HUMAN | RIB43A-like with coiled-coils protein 2 | Homo | <M><G><S><Q><T><M><A><V><A><L><P><R><D><L><R><Q><D><A><N><L><A><K><R><R><H><A><E><L><C><R><Q><K><R><V><F><N><A><R><N><R><I><I><G><G><D><T><E><A><W><D><V><Q><V><H><D><Q><K><I><K><E><A><T><E><K><A><R><H><E><T><F><A><A><E><M><R><Q><N><D><K><I><M><C><I><L><E><N><R><K><K><R><D><R><K><N><L><C><R><A><I><N><D><F><Q><Q><S><F><Q><K><P><E><T><R><R><E><F><D><L><S><D><P><L><A><L><K><K><D><L><P><A><R><Q><S><D><N><D><V><R><N><T><I><S><G><M><Q><K><F><M><G><E><D><L><N><F><H><E><R><K><K><F><Q><E><E><Q><N><R><E><W><S><L><Q><Q><Q><R><E><W><K><N><A><R><A><E><Q><K><C><A><E><A><L><Y><T><E><T><R><L><Q><F><D><E><T><A><K><H><L><Q><K><L><E><S><T><T><R><K><A><V><C><A><S><V><K><D><F><N><K><S><Q><A><I><E><S><V><E><R><K><K><Q><E><K><K><Q><E><Q><E><D><N><L><A><E><I><T><N><L><L><R><G><D><L><L><S><E><N><P><Q><Q><A><A><S><S><F><G><P><H><R><V><V><P><D><R><W><K><G><M><T><Q><E><Q><L><E><Q><I><R><L><V><Q><K><Q><Q><I><Q><E><K><L><R><L><Q><E><E><K><R><Q><R><D><L><D><W><D><R><R><R><I><Q><G><A><R><A><T><L><L><F><E><R><Q><Q><W><R><R><Q><R><D><L><R><R><A><L><D><S><S><N><L><S><L><A><K><E><Q><H><L><Q><K><K><Y><M><N><E><V><Y><T><N><Q><P><T><G><D><Y><F><T><Q><F><N><T><G><S><R> | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP> | Q9H4K1 |
P09012 | SNRPA_HUMAN | U1 small nuclear ribonucleoprotein A | Homo | <M><A><V><P><E><T><R><P><N><H><T><I><Y><I><N><N><L><N><E><K><I><K><K><D><E><L><K><K><S><L><Y><A><I><F><S><Q><F><G><Q><I><L><D><I><L><V><S><R><S><L><K><M><R><G><Q><A><F><V><I><F><K><E><V><S><S><A><T><N><A><L><R><S><M><Q><G><F><P><F><Y><D><K><P><M><R><I><Q><Y><A><K><T><D><S><D><I><I><A><K><M><K><G><T><F><V><E><R><D><R><K><R><E><K><R><K><P><K><S><Q><E><T><P><A><T><K><K><A><V><Q><G><G><G><A><T><P><V><V><G><A><V><Q><G><P><V><P><G><M><P><P><M><T><Q><A><P><R><I><M><H><H><M><P><G><Q><P><P><Y><M><P><P><P><G><M><I><P><P><P><G><L><A><P><G><Q><I><P><P><G><A><M><P><P><Q><Q><L><M><P><G><Q><M><P><P><A><Q><P><L><S><E><N><P><P><N><H><I><L><F><L><T><N><L><P><E><E><T><N><E><L><M><L><S><M><L><F><N><Q><F><P><G><F><K><E><V><R><L><V><P><G><R><H><D><I><A><F><V><E><F><D><N><E><V><Q><A><G><A><A><R><D><A><L><Q><G><F><K><I><T><Q><N><N><A><M><K><I><S><F><A><K><K> | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.<BOP> | P09012 |
Q9Y2B2 | PIGL_HUMAN | Phosphatidylinositol-glycan biosynthesis class L protein | Homo | <M><E><A><M><W><L><L><C><V><A><L><A><V><L><A><W><G><F><L><W><V><W><D><S><S><E><R><M><K><S><R><E><Q><G><G><R><L><G><A><E><S><R><T><L><L><V><I><A><H><P><D><D><E><A><M><F><F><A><P><T><V><L><G><L><A><R><L><R><H><W><V><Y><L><L><C><F><S><A><G><N><Y><Y><N><Q><G><E><T><R><K><K><E><L><L><Q><S><C><D><V><L><G><I><P><L><S><S><V><M><I><I><D><N><R><D><F><P><D><D><P><G><M><Q><W><D><T><E><H><V><A><R><V><L><L><Q><H><I><E><V><N><G><I><N><L><V><V><T><F><D><A><G><G><V><S><G><H><S><N><H><I><A><L><Y><A><A><V><R><A><L><H><S><E><G><K><L><P><K><G><C><S><V><L><T><L><Q><S><V><N><V><L><R><K><Y><I><S><L><L><D><L><P><L><S><L><L><H><T><Q><D><V><L><F><V><L><N><S><K><E><V><A><Q><A><K><K><A><M><S><C><H><R><S><Q><L><L><W><F><R><R><L><Y><I><I><F><S><R><Y><M><R><I><N><S><L><S><F><L> | Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.<BOP> | Q9Y2B2 |
O95760 | IL33_HUMAN | Interleukin-33 (109-270) | Homo | <M><K><P><K><M><K><Y><S><T><N><K><I><S><T><A><K><W><K><N><T><A><S><K><A><L><C><F><K><L><G><K><S><Q><Q><K><A><K><E><V><C><P><M><Y><F><M><K><L><R><S><G><L><M><I><K><K><E><A><C><Y><F><R><R><E><T><T><K><R><P><S><L><K><T><G><R><K><H><K><R><H><L><V><L><A><A><C><Q><Q><Q><S><T><V><E><C><F><A><F><G><I><S><G><V><Q><K><Y><T><R><A><L><H><D><S><S><I><T><G><I><S><P><I><T><E><Y><L><A><S><L><S><T><Y><N><D><Q><S><I><T><F><A><L><E><D><E><S><Y><E><I><Y><V><E><D><L><K><K><D><E><K><K><D><K><V><L><L><S><Y><Y><E><S><Q><H><P><S><N><E><S><G><D><G><V><D><G><K><M><L><M><V><T><L><S><P><T><K><D><F><W><L><H><A><N><N><K><E><H><S><V><E><L><H><K><C><E><K><P><L><P><D><Q><A><F><F><V><L><H><N><M><H><S><N><C><V><S><F><E><C><K><T><D><P><G><V><F><I><G><V><K><D><N><H><L><A><L><I><K><V><D><S><S><E><N><L><C><T><E><N><I><L><F><K><L><S><E><T> | In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets . This form is rapidely lost upon angiogenic or pro-inflammatory activation .<BOP> | O95760 |
Q9HAU8 | RNPL1_HUMAN | Methionyl aminopeptidase | Homo | <M><A><A><Q><C><C><C><R><Q><A><P><G><A><E><A><A><P><V><R><P><P><P><E><P><P><P><A><L><D><V><A><S><A><S><S><A><Q><L><F><R><L><R><H><L><Q><L><G><L><E><L><R><P><E><A><R><E><L><A><G><C><L><V><L><E><L><C><A><L><R><P><A><P><R><A><L><V><L><D><A><H><P><A><L><R><L><H><S><A><A><F><R><R><A><P><A><A><A><A><E><T><P><C><A><F><A><F><S><A><P><G><P><G><P><A><P><P><P><P><L><P><A><F><P><E><A><P><G><S><E><P><A><C><C><P><L><A><F><R><V><D><P><F><T><D><Y><G><S><S><L><T><V><T><L><P><P><E><L><Q><A><H><Q><P><F><Q><V><I><L><R><Y><T><S><T><D><A><P><A><I><W><W><L><D><P><E><L><T><Y><G><C><A><K><P><F><V><F><T><Q><G><H><S><V><C><N><R><S><F><F><P><C><F><D><T><P><A><V><K><C><T><Y><S><A><V><V><K><A><P><S><G><V><Q><V><L><M><S><A><T><R><S><A><Y><M><E><E><E><G><V><F><H><F><H><M><E><H><P><V><P><A><Y><L><V><A><L><V><A><G><D><L><K><P><A><D><I><G><P><R><S><R><V><W><A><E><P><C><L><L><P><T><A><T><S><K><L><S><G><A><V><E><Q><W><L><S><A><A><E><R><L><Y><G><P><Y><M><W><G><R><Y><D><I><V><F><L><P><P><S><F><P><I><V><A><M><E><N><P><C><L><T><F><I><I><S><S><I><L><E><S><D><E><F><L><V><I><D><V><I><H><E><V><A><H><S><W><F><G><N><A><V><T><N><A><T><W><E><E><M><W><L><S><E><G><L><A><T><Y><A><Q><R><R><I><T><T><E><T><Y><G><A><A><F><T><C><L><E><T><A><F><R><L><D><A><L><H><R><Q><M><K><L><L><G><E><D><S><P><V><S><K><L><Q><V><K><L><E><P><G><V><N><P><S><H><L><M><N><L><F><T><Y><E><K><G><Y><C><F><V><Y><Y><L><S><Q><L><C><G><D><P><Q><R><F><D><D><F><L><R><A><Y><V><E><K><Y><K><F><T><S><V><V><A><Q><D><L><L><D><S><F><L><S><F><F><P><E><L><K><E><Q><S><V><D><C><R><A><G><L><E><F><E><R><W><L><N><A><T><G><P><P><L><A><E><P><D><L><S><Q><G><S><S><L><T><R><P><V><E><A><L><F><Q><L><W><T><A><E><P><L><D><Q><A><A><A><S><A><S><A><I><D><I><S><K><W><R><T><F><Q><T><A><L><F><L><D><R><L><L><D><G><S><P><L><P><Q><E><V><V><M><S><L><S><K><C><Y><S><S><L><L><D><S><M><N><A><E><I><R><I><R><W><L><Q><I><V><V><R><N><D><Y><Y><P><D><L><H><R><V><R><R><F><L><E><S><Q><M><S><R><M><Y><T><I><P><L><Y><E><D><L><C><T><G><A><L><K><S><F><A><L><E><V><F><Y><Q><T><Q><G><R><L><H><P><N><L><R><R><A><I><Q><Q><I><L><S><Q><G><L><G><S><S><T><E><P><A><S><E><P><S><T><E><L><G><K><A><E><A><D><T><D><S><D><A><Q><A><L><L><L><G><D><E><A><P><S><S><A><I><S><L><R><D><V><N><V><S><A> | Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine.<BOP> | Q9HAU8 |
Q9ULC3 | RAB23_HUMAN | Ras-related protein Rab-23 | Homo | <M><L><E><E><D><M><E><V><A><I><K><M><V><V><V><G><N><G><A><V><G><K><S><S><M><I><Q><R><Y><C><K><G><I><F><T><K><D><Y><K><K><T><I><G><V><D><F><L><E><R><Q><I><Q><V><N><D><E><D><V><R><L><M><L><W><D><T><A><G><Q><E><E><F><D><A><I><T><K><A><Y><Y><R><G><A><Q><A><C><V><L><V><F><S><T><T><D><R><E><S><F><E><A><V><S><S><W><R><E><K><V><V><A><E><V><G><D><I><P><T><V><L><V><Q><N><K><I><D><L><L><D><D><S><C><I><K><N><E><E><A><E><A><L><A><K><R><L><K><L><R><F><Y><R><T><S><V><K><E><D><L><N><V><N><E><V><F><K><Y><L><A><E><K><Y><L><Q><K><L><K><Q><Q><I><A><E><D><P><E><L><T><H><S><S><S><N><K><I><G><V><F><N><T><S><G><G><S><H><S><G><Q><N><S><G><T><L><N><G><G><D><V><I><N><L><R><P><N><K><Q><R><T><K><K><N><R><N><P><F><S><S><C><S><I><P> | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.<BOP> | Q9ULC3 |
Q96N20 | ZN75A_HUMAN | Zinc finger protein 75A | Homo | <M><Y><F><S><Q><E><E><W><E><L><L><D><P><T><Q><K><A><L><Y><N><D><V><M><Q><E><N><Y><E><T><V><I><S><L><A><L><F><V><L><P><K><P><K><V><I><S><C><L><E><Q><G><E><E><P><W><V><Q><V><S><P><E><F><K><D><S><A><G><K><S><P><T><G><L><K><L><K><N><D><T><E><N><H><Q><P><V><S><L><S><D><L><E><I><Q><A><S><A><G><V><I><S><K><K><A><K><V><K><V><P><Q><K><T><A><G><K><E><N><H><F><D><M><H><R><V><G><K><W><H><Q><D><F><P><V><K><K><R><K><K><L><S><T><W><K><Q><E><L><L><K><L><M><D><R><H><K><K><D><C><A><R><E><K><P><F><K><C><Q><E><C><G><K><T><F><R><V><S><S><D><L><I><K><H><Q><R><I><H><T><E><E><K><P><Y><K><C><Q><Q><C><D><K><R><F><R><W><S><S><D><L><N><K><H><L><T><T><H><Q><G><I><K><P><Y><K><C><S><W><C><G><K><S><F><S><Q><N><T><N><L><H><T><H><Q><R><T><H><T><G><E><K><P><F><T><C><H><E><C><G><K><K><F><S><Q><N><S><H><L><I><K><H><R><R><T><H><T><G><E><Q><P><Y><T><C><S><I><C><R><R><N><F><S><R><R><S><S><L><L><R><H><Q><K><L><H><L> | May be involved in transcriptional regulation.<BOP> | Q96N20 |
Q6ZN57 | ZFP2_HUMAN | Zinc finger protein 751 | Homo | <M><E><R><E><G><I><W><H><S><T><L><G><E><T><W><E><P><N><N><W><L><E><G><Q><Q><D><S><H><L><S><Q><V><G><V><T><H><K><E><T><F><T><E><M><R><V><C><G><G><N><E><F><E><R><C><S><S><Q><D><S><I><L><D><T><Q><Q><S><I><P><M><V><K><R><P><H><N><C><N><S><H><G><E><D><A><T><Q><N><S><E><L><I><K><T><Q><R><M><F><V><G><K><K><I><Y><E><C><N><Q><C><S><K><T><F><S><Q><S><S><S><L><L><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><V><C><G><K><H><F><I><E><R><S><S><L><T><V><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><Q><S><M><N><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><H><K><N><S><S><L><I><Q><H><E><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><T><Q><S><M><N><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><S><M><H><L><I><V><H><Q><R><S><H><T><G><E><K><P><Y><E><C><S><Q><C><G><K><A><F><S><K><S><S><T><L><T><L><H><Q><R><N><H><T><G><E><K><P><Y><K><C><N><K><C><G><K><S><F><S><Q><S><T><Y><L><I><E><H><Q><R><L><H><S><G><V><K><P><F><E><C><N><E><C><G><K><A><F><S><K><N><S><S><L><T><Q><H><R><R><I><H><T><G><E><K><P><Y><E><C><M><V><C><G><K><H><F><T><G><R><S><S><L><T><V><H><Q><V><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><S><A><Y><L><I><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><D><Q><C><G><K><A><F><I><K><N><S><S><L><T><V><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><N><E><C><G><K><A><F><S><R><S><T><N><L><T><R><H><Q><R><T><H><T> | Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.<BOP> | Q6ZN57 |
Q86T96 | RN180_HUMAN | RING-type E3 ubiquitin transferase RNF180 | Homo | <M><K><R><S><K><E><L><I><T><K><N><H><S><Q><E><E><T><S><I><L><R><C><W><K><C><R><K><C><I><A><S><S><G><C><F><M><E><Y><L><E><N><Q><V><I><K><D><K><D><D><S><V><D><A><Q><N><I><C><H><V><W><H><M><N><V><E><A><L><P><E><W><I><S><C><L><I><Q><K><A><Q><W><T><V><G><K><L><N><C><P><F><C><G><A><R><L><G><G><F><N><F><V><S><T><P><K><C><S><C><G><Q><L><A><A><V><H><L><S><K><S><R><T><D><Y><Q><P><T><Q><A><G><R><L><M><R><P><S><V><K><Y><L><S><H><P><R><V><Q><S><G><C><D><K><E><A><L><L><T><G><G><G><S><E><N><R><N><H><R><L><L><N><M><A><R><N><N><N><D><P><G><R><L><T><E><A><L><C><L><E><V><R><P><T><Y><F><E><M><K><N><E><K><L><L><S><K><A><S><E><P><K><Y><Q><L><F><V><P><Q><L><V><T><G><R><C><A><T><R><A><F><H><R><K><S><H><S><L><D><L><N><I><S><E><K><L><T><L><L><P><T><L><Y><E><I><H><S><K><T><T><A><Y><S><R><L><N><E><T><Q><P><I><D><L><S><G><L><P><L><Q><S><S><K><N><S><Y><S><F><Q><N><P><S><S><F><D><P><S><M><L><L><Q><R><F><S><V><A><P><H><E><T><Q><T><Q><R><G><G><E><F><Q><C><G><L><E><A><A><S><V><Y><S><D><H><T><N><T><N><N><L><T><F><L><M><D><L><P><S><A><G><R><S><M><P><E><A><S><D><Q><E><E><H><L><S><P><L><D><F><L><H><S><A><N><F><S><L><G><S><I><N><Q><R><L><N><K><R><E><R><S><K><L><K><N><L><R><R><K><Q><R><R><R><E><R><W><L><Q><K><Q><G><K><Y><S><G><V><G><L><L><D><H><M><T><L><N><N><E><M><S><T><D><E><D><N><E><Y><A><E><E><K><D><S><Y><I><C><A><V><C><L><D><V><Y><F><N><P><Y><M><C><Y><P><C><H><H><I><F><C><E><P><C><L><R><T><L><A><K><D><N><P><S><S><T><P><C><P><L><C><R><T><I><I><S><R><V><F><F><Q><T><E><L><N><N><A><T><K><T><F><F><T><K><E><Y><L><K><I><K><Q><S><F><Q><K><S><N><S><A><K><W><P><L><P><S><C><R><K><A><F><H><L><F><G><G><F><R><R><H><A><A><P><V><T><R><R><Q><F><P><H><G><A><H><R><M><D><Y><L><H><F><E><D><D><S><R><G><W><W><F><D><M><D><M><V><I><I><Y><I><Y><S><V><N><W><V><I><G><F><I><V><F><C><F><L><C><Y><F><F><F><P><F> | E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.<BOP> | Q86T96 |
A0A0B4J235 | TVAM2_HUMAN | T cell receptor alpha variable 13-2 | Homo | <M><A><G><I><R><A><L><F><M><Y><L><W><L><Q><L><D><W><V><S><R><G><E><S><V><G><L><H><L><P><T><L><S><V><Q><E><G><D><N><S><I><I><N><C><A><Y><S><N><S><A><S><D><Y><F><I><W><Y><K><Q><E><S><G><K><G><P><Q><F><I><I><D><I><R><S><N><M><D><K><R><Q><G><Q><R><V><T><V><L><L><N><K><T><V><K><H><L><S><L><Q><I><A><A><T><Q><P><G><D><S><A><V><Y><F><C><A><E><N> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J235 |
Q02878 | RL6_HUMAN | Tax-responsive enhancer element-binding protein 107 | Homo | <M><A><G><E><K><V><E><K><P><D><T><K><E><K><K><P><E><A><K><K><V><D><A><G><G><K><V><K><K><G><N><L><K><A><K><K><P><K><K><G><K><P><H><C><S><R><N><P><V><L><V><R><G><I><G><R><Y><S><R><S><A><M><Y><S><R><K><A><M><Y><K><R><K><Y><S><A><A><K><S><K><V><E><K><K><K><K><E><K><V><L><A><T><V><T><K><P><V><G><G><D><K><N><G><G><T><R><V><V><K><L><R><K><M><P><R><Y><Y><P><T><E><D><V><P><R><K><L><L><S><H><G><K><K><P><F><S><Q><H><V><R><K><L><R><A><S><I><T><P><G><T><I><L><I><I><L><T><G><R><H><R><G><K><R><V><V><F><L><K><Q><L><A><S><G><L><L><L><V><T><G><P><L><V><L><N><R><V><P><L><R><R><T><H><Q><K><F><V><I><A><T><S><T><K><I><D><I><S><N><V><K><I><P><K><H><L><T><D><A><Y><F><K><K><K><K><L><R><K><P><R><H><Q><E><G><E><I><F><D><T><E><K><E><K><Y><E><I><T><E><Q><R><K><I><D><Q><K><A><V><D><S><Q><I><L><P><K><I><K><A><I><P><Q><L><Q><G><Y><L><R><S><V><F><A><L><T><N><G><I><Y><P><H><K><L><V><F> | (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I .<BOP> | Q02878 |
Q1L6U9 | MSMP_HUMAN | PC3-secreted microprotein | Homo | <M><A><L><R><M><L><W><A><G><Q><A><K><G><I><L><G><G><W><G><I><I><C><L><V><M><S><L><L><L><Q><H><P><G><V><Y><S><K><C><Y><F><Q><A><Q><A><P><C><H><Y><E><G><K><Y><F><T><L><G><E><S><W><L><R><K><D><C><F><H><C><T><C><L><H><P><V><G><V><G><C><C><D><T><S><Q><H><P><I><D><F><P><A><G><C><E><V><R><Q><E><A><G><T><C><Q><F><S><L><V><Q><K><S><D><P><R><L><P><C><K><G><G><G><P><D><P><E><W><G><S><A><N><T><P><V><P><G><A><P><A><P><H><S><S> | Acts as a ligand for C-C chemokine receptor CCR2 . Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions . Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils .<BOP> | Q1L6U9 |
Q2KHT4 | GSG1_HUMAN | Germ cell-specific gene 1 protein | Homo | <M><A><K><M><E><L><S><K><A><F><S><G><Q><R><T><L><L><S><A><I><L><S><M><L><S><L><S><F><S><T><T><S><L><L><S><N><Y><W><F><V><G><T><Q><K><V><P><K><P><L><C><E><K><G><L><A><A><K><C><F><D><M><P><V><S><L><D><G><D><T><N><T><S><T><Q><E><V><V><Q><Y><N><W><E><T><G><D><D><R><F><S><F><R><S><F><R><S><G><M><W><L><S><C><E><E><T><V><E><E><P><A><L><L><H><P><Q><S><W><K><Q><F><R><A><L><R><S><S><G><T><A><A><A><K><G><E><R><C><R><S><F><I><E><L><T><P><P><A><K><R><E><I><L><W><L><S><L><G><T><Q><I><T><Y><I><G><L><Q><F><I><S><F><L><L><L><L><T><D><L><L><L><T><G><N><P><A><C><G><L><K><L><S><A><F><A><A><V><S><S><V><L><S><G><L><L><G><M><V><A><H><M><M><Y><S><Q><V><F><Q><A><T><V><N><L><G><P><E><D><W><R><P><H><V><W><N><Y><G><W><A><F><Y><M><A><W><L><S><F><T><C><C><M><A><S><A><V><T><T><F><N><T><Y><T><R><M><V><L><E><F><K><C><K><H><S><K><S><F><K><E><N><P><N><C><L><P><H><H><H><Q><C><F><P><R><R><L><S><S><A><A><P><T><V><G><P><L><T><S><Y><H><Q><Y><H><N><Q><P><I><H><S><V><S><E><G><V><D><F><Y><S><E><L><R><N><K><G><F><Q><R><G><A><S><Q><E><L><K><E><A><V><R><S><S><V><E><E><E><Q><C> | May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.<BOP> | Q2KHT4 |
Q9HBL7 | PLRKT_HUMAN | Plasminogen receptor (KT) | Homo | <M><G><F><I><F><S><K><S><M><N><E><S><M><K><N><Q><K><E><F><M><L><M><N><A><R><L><Q><L><E><R><Q><L><I><M><Q><S><E><M><R><E><R><Q><M><A><M><Q><I><A><W><S><R><E><F><L><K><Y><F><G><T><F><F><G><L><A><A><I><S><L><T><A><G><A><I><K><K><K><K><P><A><F><L><V><P><I><V><P><L><S><F><I><L><T><Y><Q><Y><D><L><G><Y><G><T><L><L><E><R><M><K><G><E><A><E><D><I><L><E><T><E><K><S><K><L><Q><L><P><R><G><M><I><T><F><E><S><I><E><K><A><R><K><E><Q><S><R><F><F><I><D><K> | Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.<BOP> | Q9HBL7 |
P78314 | 3BP2_HUMAN | SH3 domain-binding protein 2 | Homo | <M><A><A><E><E><M><H><W><P><V><P><M><K><A><I><G><A><Q><N><L><L><T><M><P><G><G><V><A><K><A><G><Y><L><H><K><K><G><G><T><Q><L><Q><L><L><K><W><P><L><R><F><V><I><I><H><K><R><C><V><Y><Y><F><K><S><S><T><S><A><S><P><Q><G><A><F><S><L><S><G><Y><N><R><V><M><R><A><A><E><E><T><T><S><N><N><V><F><P><F><K><I><I><H><I><S><K><K><H><R><T><W><F><F><S><A><S><S><E><E><E><R><K><S><W><M><A><L><L><R><R><E><I><G><H><F><H><E><K><K><D><L><P><L><D><T><S><D><S><S><S><D><T><D><S><F><Y><G><A><V><E><R><P><V><D><I><S><L><S><P><Y><P><T><D><N><E><D><Y><E><H><D><D><E><D><D><S><Y><L><E><P><D><S><P><E><P><G><R><L><E><D><A><L><M><H><P><P><A><Y><P><P><P><P><V><P><T><P><R><K><P><A><F><S><D><M><P><R><A><H><S><F><T><S><K><G><P><G><P><L><L><P><P><P><P><P><K><H><G><L><P><D><V><G><L><A><A><E><D><S><K><R><D><P><L><C><P><R><R><A><E><P><C><P><R><V><P><A><T><P><R><R><M><S><D><P><P><L><S><T><M><P><T><A><P><G><L><R><K><P><P><C><F><R><E><S><A><S><P><S><P><E><P><W><T><P><G><H><G><A><C><S><T><S><S><A><A><I><M><A><T><A><T><S><R><N><C><D><K><L><K><S><F><H><L><S><P><R><G><P><P><T><S><E><P><P><P><V><P><A><N><K><P><K><F><L><K><I><A><E><E><D><P><P><R><E><A><A><M><P><G><L><F><V><P><P><V><A><P><R><P><P><A><L><K><L><P><V><P><E><A><M><A><R><P><A><V><L><P><R><P><E><K><P><Q><L><P><H><L><Q><R><S><P><P><D><G><Q><S><F><R><S><F><S><F><E><K><P><R><Q><P><S><Q><A><D><T><G><G><D><D><S><D><E><D><Y><E><K><V><P><L><P><N><S><V><F><V><N><T><T><E><S><C><E><V><E><R><L><F><K><A><T><S><P><R><G><E><P><Q><D><G><L><Y><C><I><R><N><S><S><T><K><S><G><K><V><L><V><V><W><D><E><T><S><N><K><V><R><N><Y><R><I><F><E><K><D><S><K><F><Y><L><E><G><E><V><L><F><V><S><V><G><S><M><V><E><H><Y><H><T><H><V><L><P><S><H><Q><S><L><L><L><R><H><P><Y><G><Y><T><G><P><R> | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.<BOP> | P78314 |
Q86SX6 | GLRX5_HUMAN | Monothiol glutaredoxin-5 | Homo | <M><S><G><S><L><G><R><A><A><A><A><L><L><R><W><G><R><G><A><G><G><G><G><L><W><G><P><G><V><R><A><A><G><S><G><A><G><G><G><G><S><A><E><Q><L><D><A><L><V><K><K><D><K><V><V><V><F><L><K><G><T><P><E><Q><P><Q><C><G><F><S><N><A><V><V><Q><I><L><R><L><H><G><V><R><D><Y><A><A><Y><N><V><L><D><D><P><E><L><R><Q><G><I><K><D><Y><S><N><W><P><T><I><P><Q><V><Y><L><N><G><E><F><V><G><G><C><D><I><L><L><Q><M><H><Q><N><G><D><L><V><E><E><L><K><K><L><G><I><H><S><A><L><L><D><E><K><K><D><Q><D><S><K> | Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer . Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion . Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 .<BOP> | Q86SX6 |
P02766 | TTHY_HUMAN | TBPA | Homo | <M><A><S><H><R><L><L><L><L><C><L><A><G><L><V><F><V><S><E><A><G><P><T><G><T><G><E><S><K><C><P><L><M><V><K><V><L><D><A><V><R><G><S><P><A><I><N><V><A><V><H><V><F><R><K><A><A><D><D><T><W><E><P><F><A><S><G><K><T><S><E><S><G><E><L><H><G><L><T><T><E><E><E><F><V><E><G><I><Y><K><V><E><I><D><T><K><S><Y><W><K><A><L><G><I><S><P><F><H><E><H><A><E><V><V><F><T><A><N><D><S><G><P><R><R><Y><T><I><A><A><L><L><S><P><Y><S><Y><S><T><T><A><V><V><T><N><P><K><E> | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<BOP> | P02766 |
Q9Y5L2 | HLPDA_HUMAN | Hypoxia-inducible gene 2 protein | Homo | <M><K><H><V><L><N><L><Y><L><L><G><V><V><L><T><L><L><S><I><F><V><R><V><M><E><S><L><E><G><L><L><E><S><P><S><P><G><T><S><W><T><T><R><S><Q><L><A><N><T><E><P><T><K><G><L><P><D><H><P><S><R><S><M> | Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.<BOP> | Q9Y5L2 |
P16442 | BGAT_HUMAN | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form | Homo | <M><A><E><V><L><R><T><L><A><G><K><P><K><C><H><A><L><R><P><M><I><L><F><L><I><M><L><V><L><V><L><F><G><Y><G><V><L><S><P><R><S><L><M><P><G><S><L><E><R><G><F><C><M><A><V><R><E><P><D><H><L><Q><R><V><S><L><P><R><M><V><Y><P><Q><P><K><V><L><T><P><C><R><K><D><V><L><V><V><T><P><W><L><A><P><I><V><W><E><G><T><F><N><I><D><I><L><N><E><Q><F><R><L><Q><N><T><T><I><G><L><T><V><F><A><I><K><K><Y><V><A><F><L><K><L><F><L><E><T><A><E><K><H><F><M><V><G><H><R><V><H><Y><Y><V><F><T><D><Q><P><A><A><V><P><R><V><T><L><G><T><G><R><Q><L><S><V><L><E><V><R><A><Y><K><R><W><Q><D><V><S><M><R><R><M><E><M><I><S><D><F><C><E><R><R><F><L><S><E><V><D><Y><L><V><C><V><D><V><D><M><E><F><R><D><H><V><G><V><E><I><L><T><P><L><F><G><T><L><H><P><G><F><Y><G><S><S><R><E><A><F><T><Y><E><R><R><P><Q><S><Q><A><Y><I><P><K><D><E><G><D><F><Y><Y><L><G><G><F><F><G><G><S><V><Q><E><V><Q><R><L><T><R><A><C><H><Q><A><M><M><V><D><Q><A><N><G><I><E><A><V><W><H><D><E><S><H><L><N><K><Y><L><L><R><H><K><P><T><K><V><L><S><P><E><Y><L><W><D><Q><Q><L><L><G><W><P><A><V><L><R><K><L><R><F><T><A><V><P><K><N><H><Q><A><V><R><N><P> | This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.<BOP> | P16442 |
Q02156 | KPCE_HUMAN | nPKC-epsilon | Homo | <M><V><V><F><N><G><L><L><K><I><K><I><C><E><A><V><S><L><K><P><T><A><W><S><L><R><H><A><V><G><P><R><P><Q><T><F><L><L><D><P><Y><I><A><L><N><V><D><D><S><R><I><G><Q><T><A><T><K><Q><K><T><N><S><P><A><W><H><D><E><F><V><T><D><V><C><N><G><R><K><I><E><L><A><V><F><H><D><A><P><I><G><Y><D><D><F><V><A><N><C><T><I><Q><F><E><E><L><L><Q><N><G><S><R><H><F><E><D><W><I><D><L><E><P><E><G><R><V><Y><V><I><I><D><L><S><G><S><S><G><E><A><P><K><D><N><E><E><R><V><F><R><E><R><M><R><P><R><K><R><Q><G><A><V><R><R><R><V><H><Q><V><N><G><H><K><F><M><A><T><Y><L><R><Q><P><T><Y><C><S><H><C><R><D><F><I><W><G><V><I><G><K><Q><G><Y><Q><C><Q><V><C><T><C><V><V><H><K><R><C><H><E><L><I><I><T><K><C><A><G><L><K><K><Q><E><T><P><D><Q><V><G><S><Q><R><F><S><V><N><M><P><H><K><F><G><I><H><N><Y><K><V><P><T><F><C><D><H><C><G><S><L><L><W><G><L><L><R><Q><G><L><Q><C><K><V><C><K><M><N><V><H><R><R><C><E><T><N><V><A><P><N><C><G><V><D><A><R><G><I><A><K><V><L><A><D><L><G><V><T><P><D><K><I><T><N><S><G><Q><R><R><K><K><L><I><A><G><A><E><S><P><Q><P><A><S><G><S><S><P><S><E><E><D><R><S><K><S><A><P><T><S><P><C><D><Q><E><I><K><E><L><E><N><N><I><R><K><A><L><S><F><D><N><R><G><E><E><H><R><A><A><S><S><P><D><G><Q><L><M><S><P><G><E><N><G><E><V><R><Q><G><Q><A><K><R><L><G><L><D><E><F><N><F><I><K><V><L><G><K><G><S><F><G><K><V><M><L><A><E><L><K><G><K><D><E><V><Y><A><V><K><V><L><K><K><D><V><I><L><Q><D><D><D><V><D><C><T><M><T><E><K><R><I><L><A><L><A><R><K><H><P><Y><L><T><Q><L><Y><C><C><F><Q><T><K><D><R><L><F><F><V><M><E><Y><V><N><G><G><D><L><M><F><Q><I><Q><R><S><R><K><F><D><E><P><R><S><R><F><Y><A><A><E><V><T><S><A><L><M><F><L><H><Q><H><G><V><I><Y><R><D><L><K><L><D><N><I><L><L><D><A><E><G><H><C><K><L><A><D><F><G><M><C><K><E><G><I><L><N><G><V><T><T><T><T><F><C><G><T><P><D><Y><I><A><P><E><I><L><Q><E><L><E><Y><G><P><S><V><D><W><W><A><L><G><V><L><M><Y><E><M><M><A><G><Q><P><P><F><E><A><D><N><E><D><D><L><F><E><S><I><L><H><D><D><V><L><Y><P><V><W><L><S><K><E><A><V><S><I><L><K><A><F><M><T><K><N><P><H><K><R><L><G><C><V><A><S><Q><N><G><E><D><A><I><K><Q><H><P><F><F><K><E><I><D><W><V><L><L><E><Q><K><K><I><K><P><P><F><K><P><R><I><K><T><K><R><D><V><N><N><F><D><Q><D><F><T><R><E><E><P><V><L><T><L><V><D><E><A><I><V><K><Q><I><N><Q><E><E><F><K><G><F><S><Y><F><G><E><D><L><M><P> | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment | Q02156 |
Q9HBI1 | PARVB_HUMAN | Affixin | Homo | <M><S><S><A><P><R><S><P><T><P><R><P><R><R><M><K><K><D><E><S><F><L><G><K><L><G><G><T><L><A><R><K><R><R><A><R><E><V><S><D><L><Q><E><E><G><K><N><A><I><N><S><P><M><S><P><A><L><V><D><V><H><P><E><D><T><Q><L><E><E><N><E><E><R><T><M><I><D><P><T><S><K><E><D><P><K><F><K><E><L><V><K><V><L><L><D><W><I><N><D><V><L><V><E><E><R><I><I><V><K><Q><L><E><E><D><L><Y><D><G><Q><V><L><Q><K><L><L><E><K><L><A><G><C><K><L><N><V><A><E><V><T><Q><S><E><I><G><Q><K><Q><K><L><Q><T><V><L><E><A><V><H><D><L><L><R><P><R><G><W><A><L><R><W><S><V><D><S><I><H><G><K><N><L><V><A><I><L><H><L><L><V><S><L><A><M><H><F><R><A><P><I><R><L><P><E><H><V><T><V><Q><V><V><V><V><R><K><R><E><G><L><L><H><S><S><H><I><S><E><E><L><T><T><T><T><E><M><M><M><G><R><F><E><R><D><A><F><D><T><L><F><D><H><A><P><D><K><L><S><V><V><K><K><S><L><I><T><F><V><N><K><H><L><N><K><L><N><L><E><V><T><E><L><E><T><Q><F><A><D><G><V><Y><L><V><L><L><M><G><L><L><E><D><Y><F><V><P><L><H><H><F><Y><L><T><P><E><S><F><D><Q><K><V><H><N><V><S><F><A><F><E><L><M><L><D><G><G><L><K><K><P><K><A><R><P><E><D><V><V><N><L><D><L><K><S><T><L><R><V><L><Y><N><L><F><T><K><Y><K><N><V><E> | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.<BOP> | Q9HBI1 |
P63131 | VPK7_HUMAN | Proteinase | Homo | <W><A><S><Q><V><S><E><N><R><P><V><C><K><A><I><I><Q><G><K><Q><F><E><G><L><V><D><T><G><A><D><V><S><I><I><A><L><N><Q><W><P><K><N><W><P><K><Q><K><A><V><T><G><L><V><G><I><G><T><A><S><E><V><Y><Q><S><T><E><I><L><H><C><L><G><P><D><N><Q><E><S><T><V><Q><P><M><I><T><S><I><P><L><N><L><W><G><R><D><L><L><Q><Q><W><G><A><E><I><T><M><P><A><P><L><Y><S><P><T><S><Q><K><I><M><T><K><M><G><Y><I><P><G><K><G><L><G><K><N><E><D><G><I><K><V><P><V><E><A><K><I><N><Q><E><R><E><G><I><G><Y><P><F> | Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein has retained most of the characteristics of retroviral proteases.<BOP> | P63131 |
Q6ZUT3 | FRMD7_HUMAN | FERM domain-containing protein 7 | Homo | <M><L><H><L><K><V><Q><F><L><D><D><S><Q><K><I><F><V><V><D><Q><K><S><S><G><K><A><L><F><N><L><S><C><S><H><L><N><L><A><E><K><E><Y><F><G><L><E><F><C><S><H><S><G><N><N><V><W><L><E><L><L><K><P><I><T><K><Q><V><K><N><P><K><E><I><V><F><K><F><M><V><K><F><F><P><V><D><P><G><H><L><R><E><E><L><T><R><Y><L><F><T><L><Q><I><K><K><D><L><A><L><G><R><L><P><C><S><D><N><C><T><A><L><M><V><S><H><I><L><Q><S><E><L><G><D><F><H><E><E><T><D><R><K><H><L><A><Q><T><R><Y><L><P><N><Q><D><C><L><E><G><K><I><M><H><F><H><Q><K><H><I><G><R><S><P><A><E><S><D><I><L><L><L><D><I><A><R><K><L><D><M><Y><G><I><R><P><H><P><A><S><D><G><E><G><M><Q><I><H><L><A><V><A><H><M><G><V><L><V><L><R><G><N><T><K><I><N><T><F><N><W><A><K><I><R><K><L><S><F><K><R><K><H><F><L><I><K><L><H><A><N><I><L><V><L><C><K><D><T><L><E><F><T><M><A><S><R><D><A><C><K><A><F><W><K><T><C><V><E><Y><H><A><F><F><R><L><S><E><E><P><K><S><K><P><K><T><L><L><C><S><K><G><S><S><F><R><Y><S><G><R><T><Q><R><Q><L><L><E><Y><G><R><K><G><R><L><K><S><L><P><F><E><R><K><H><Y><P><S><Q><Y><H><E><R><Q><C><R><S><S><P><D><L><L><S><D><V><S><K><Q><V><E><D><L><R><L><A><Y><G><G><G><Y><Y><Q><N><V><N><G><V><H><A><S><E><P><V><L><E><S><R><R><R><N><S><A><L><E><V><T><F><A><T><E><L><E><H><S><K><P><E><A><D><P><T><L><L><H><Q><S><Q><S><S><S><S><F><P><F><I><Y><M><D><P><V><F><N><T><E><P><N><P><N><P><D><P><R><D><I><F><S><E><R><S><S><L><S><S><F><Q><T><S><C><K><F><S><G><N><H><M><S><I><Y><S><G><L><T><S><K><V><R><P><A><K><Q><L><T><Y><T><D><V><P><Y><I><P><C><T><G><Q><Q><V><G><I><M><P><P><Q><V><F><F><Y><V><D><K><P><P><Q><V><P><R><W><S><P><I><R><A><E><E><R><T><S><P><H><S><Y><V><E><P><T><A><M><K><P><A><E><R><S><P><R><N><I><R><M><K><S><F><Q><Q><D><L><Q><V><L><Q><E><A><I><A><R><T><S><G><R><S><N><I><N><V><G><L><E><E><E><D><P><N><L><E><D><A><F><V><C><N><I><Q><E><Q><T><P><K><R><S><Q><S><Q><S><D><M><K><T><I><R><F><P><F><G><S><E><F><R><P><L><G><P><C><P><A><L><S><H><K><A><D><L><F><T><D><M><F><A><E><Q><E><L><P><A><V><L><M><D><Q><S><T><A><E><R><Y><V><A><S><E><S><S><D><S><E><S><E><I><L><K><P><D><Y><Y><A><L><Y><G><K><E><I><R><S><P><M><A><R><I><R><L><S><S><G><S><L><Q><L><D><E><E><D><E><D><A><Y><F><N><T><P><T><A><E><D><R><T><S><L><K><P><C><N><Y><F><L><A> | Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.<BOP> | Q6ZUT3 |
Q9Y6F9 | WNT6_HUMAN | Protein Wnt-6 | Homo | <M><L><P><P><L><P><S><R><L><G><L><L><L><L><L><L><L><C><P><A><H><V><G><G><L><W><W><A><V><G><S><P><L><V><M><D><P><T><S><I><C><R><K><A><R><R><L><A><G><R><Q><A><E><L><C><Q><A><E><P><E><V><V><A><E><L><A><R><G><A><R><L><G><V><R><E><C><Q><F><Q><F><R><F><R><R><W><N><C><S><S><H><S><K><A><F><G><R><I><L><Q><Q><D><I><R><E><T><A><F><V><F><A><I><T><A><A><G><A><S><H><A><V><T><Q><A><C><S><M><G><E><L><L><Q><C><G><C><Q><A><P><R><G><R><A><P><P><R><P><S><G><L><P><G><T><P><G><P><P><G><P><A><G><S><P><E><G><S><A><A><W><E><W><G><G><C><G><D><D><V><D><F><G><D><E><K><S><R><L><F><M><D><A><R><H><K><R><G><R><G><D><I><R><A><L><V><Q><L><H><N><N><E><A><G><R><L><A><V><R><S><H><T><R><T><E><C><K><C><H><G><L><S><G><S><C><A><L><R><T><C><W><Q><K><L><P><P><F><R><E><V><G><A><R><L><L><E><R><F><H><G><A><S><R><V><M><G><T><N><D><G><K><A><L><L><P><A><V><R><T><L><K><P><P><G><R><A><D><L><L><Y><A><A><D><S><P><D><F><C><A><P><N><R><R><T><G><S><P><G><T><R><G><R><A><C><N><S><S><A><P><D><L><S><G><C><D><L><L><C><C><G><R><G><H><R><Q><E><S><V><Q><L><E><E><N><C><L><C><R><F><H><W><C><C><V><V><Q><C><H><R><C><R><V><R><K><E><L><S><L><C><L> | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.<BOP> | Q9Y6F9 |
P27930 | IL1R2_HUMAN | Interleukin-1 receptor type 2, soluble form | Homo | <M><L><R><L><Y><V><L><V><M><G><V><S><A><F><T><L><Q><P><A><A><H><T><G><A><A><R><S><C><R><F><R><G><R><H><Y><K><R><E><F><R><L><E><G><E><P><V><A><L><R><C><P><Q><V><P><Y><W><L><W><A><S><V><S><P><R><I><N><L><T><W><H><K><N><D><S><A><R><T><V><P><G><E><E><E><T><R><M><W><A><Q><D><G><A><L><W><L><L><P><A><L><Q><E><D><S><G><T><Y><V><C><T><T><R><N><A><S><Y><C><D><K><M><S><I><E><L><R><V><F><E><N><T><D><A><F><L><P><F><I><S><Y><P><Q><I><L><T><L><S><T><S><G><V><L><V><C><P><D><L><S><E><F><T><R><D><K><T><D><V><K><I><Q><W><Y><K><D><S><L><L><L><D><K><D><N><E><K><F><L><S><V><R><G><T><T><H><L><L><V><H><D><V><A><L><E><D><A><G><Y><Y><R><C><V><L><T><F><A><H><E><G><Q><Q><Y><N><I><T><R><S><I><E><L><R><I><K><K><K><K><E><E><T><I><P><V><I><I><S><P><L><K><T><I><S><A><S><L><G><S><R><L><T><I><P><C><K><V><F><L><G><T><G><T><P><L><T><T><M><L><W><W><T><A><N><D><T><H><I><E><S><A><Y><P><G><G><R><V><T><E><G><P><R><Q><E><Y><S><E><N><N><E><N><Y><I><E><V><P><L><I><F><D><P><V><T><R><E><D><L><H><M><D><F><K><C><V><V><H><N><T><L><S><F><Q><T><L><R><T><T><V><K><E><A><S><S><T><F><S><W><G><I><V><L><A><P><L><S><L><A><F><L><V><L><G><G><I><W><M><H><R><R><C><K><H><R><T><G><K><A><D><G><L><T><V><L><W><P><H><H><Q><D><F><Q><S><Y><P><K> | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<BOP> | P27930 |
P49257 | LMAN1_HUMAN | Lectin mannose-binding 1 | Homo | <M><A><G><S><R><Q><R><G><L><R><A><R><V><R><P><L><F><C><A><L><L><L><S><L><G><R><F><V><R><G><D><G><V><G><G><D><P><A><V><A><L><P><H><R><R><F><E><Y><K><Y><S><F><K><G><P><H><L><V><Q><S><D><G><T><V><P><F><W><A><H><A><G><N><A><I><P><S><S><D><Q><I><R><V><A><P><S><L><K><S><Q><R><G><S><V><W><T><K><T><K><A><A><F><E><N><W><E><V><E><V><T><F><R><V><T><G><R><G><R><I><G><A><D><G><L><A><I><W><Y><A><E><N><Q><G><L><E><G><P><V><F><G><S><A><D><L><W><N><G><V><G><I><F><F><D><S><F><D><N><D><G><K><K><N><N><P><A><I><V><I><I><G><N><N><G><Q><I><H><Y><D><H><Q><N><D><G><A><S><Q><A><L><A><S><C><Q><R><D><F><R><N><K><P><Y><P><V><R><A><K><I><T><Y><Y><Q><N><T><L><T><V><M><I><N><N><G><F><T><P><D><K><N><D><Y><E><F><C><A><K><V><E><N><M><I><I><P><A><Q><G><H><F><G><I><S><A><A><T><G><G><L><A><D><D><H><D><V><L><S><F><L><T><F><Q><L><T><E><P><G><K><E><P><P><T><P><D><K><E><I><S><E><K><E><K><E><K><Y><Q><E><E><F><E><H><F><Q><Q><E><L><D><K><K><K><E><E><F><Q><K><G><H><P><D><L><Q><G><Q><P><A><E><E><I><F><E><S><V><G><D><R><E><L><R><Q><V><F><E><G><Q><N><R><I><H><L><E><I><K><Q><L><N><R><Q><L><D><M><I><L><D><E><Q><R><R><Y><V><S><S><L><T><E><E><I><S><K><R><G><A><G><M><P><G><Q><H><G><Q><I><T><Q><Q><E><L><D><T><V><V><K><T><Q><H><E><I><L><R><Q><V><N><E><M><K><N><S><M><S><E><T><V><R><L><V><S><G><M><Q><H><P><G><S><A><G><G><V><Y><E><T><T><Q><H><F><I><D><I><K><E><H><L><H><I><V><K><R><D><I><D><N><L><V><Q><R><N><M><P><S><N><E><K><P><K><C><P><E><L><P><P><F><P><S><C><L><S><T><V><H><F><I><I><F><V><V><V><Q><T><V><L><F><I><G><Y><I><M><Y><R><S><Q><Q><E><A><A><A><K><K><F><F> | Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.<BOP> | P49257 |
P06733 | ENOA_HUMAN | Plasminogen-binding protein | Homo | <M><S><I><L><K><I><H><A><R><E><I><F><D><S><R><G><N><P><T><V><E><V><D><L><F><T><S><K><G><L><F><R><A><A><V><P><S><G><A><S><T><G><I><Y><E><A><L><E><L><R><D><N><D><K><T><R><Y><M><G><K><G><V><S><K><A><V><E><H><I><N><K><T><I><A><P><A><L><V><S><K><K><L><N><V><T><E><Q><E><K><I><D><K><L><M><I><E><M><D><G><T><E><N><K><S><K><F><G><A><N><A><I><L><G><V><S><L><A><V><C><K><A><G><A><V><E><K><G><V><P><L><Y><R><H><I><A><D><L><A><G><N><S><E><V><I><L><P><V><P><A><F><N><V><I><N><G><G><S><H><A><G><N><K><L><A><M><Q><E><F><M><I><L><P><V><G><A><A><N><F><R><E><A><M><R><I><G><A><E><V><Y><H><N><L><K><N><V><I><K><E><K><Y><G><K><D><A><T><N><V><G><D><E><G><G><F><A><P><N><I><L><E><N><K><E><G><L><E><L><L><K><T><A><I><G><K><A><G><Y><T><D><K><V><V><I><G><M><D><V><A><A><S><E><F><F><R><S><G><K><Y><D><L><D><F><K><S><P><D><D><P><S><R><Y><I><S><P><D><Q><L><A><D><L><Y><K><S><F><I><K><D><Y><P><V><V><S><I><E><D><P><F><D><Q><D><D><W><G><A><W><Q><K><F><T><A><S><A><G><I><Q><V><V><G><D><D><L><T><V><T><N><P><K><R><I><A><K><A><V><N><E><K><S><C><N><C><L><L><L><K><V><N><Q><I><G><S><V><T><E><S><L><Q><A><C><K><L><A><Q><A><N><G><W><G><V><M><V><S><H><R><S><G><E><T><E><D><T><F><I><A><D><L><V><V><G><L><C><T><G><Q><I><K><T><G><A><P><C><R><S><E><R><L><A><K><Y><N><Q><L><L><R><I><E><E><E><L><G><S><K><A><K><F><A><G><R><N><F><R><N><P><L><A><K> | MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.<BOP> | P06733 |
Q9Y237 | PIN4_HUMAN | Rotamase Pin4 | Homo | <M><P><P><K><G><K><S><G><S><G><K><A><G><K><G><G><A><A><S><G><S><D><S><A><D><K><K><A><Q><G><P><K><G><G><G><N><A><V><K><V><R><H><I><L><C><E><K><H><G><K><I><M><E><A><M><E><K><L><K><S><G><M><R><F><N><E><V><A><A><Q><Y><S><E><D><K><A><R><Q><G><G><D><L><G><W><M><T><R><G><S><M><V><G><P><F><Q><E><A><A><F><A><L><P><V><S><G><M><D><K><P><V><F><T><D><P><P><V><K><T><K><F><G><Y><H><I><I><M><V><E><G><R><K> | Isoform 2 binds to double-stranded DNA.<BOP> | Q9Y237 |
Q96NI8 | ZN570_HUMAN | Zinc finger protein 570 | Homo | <M><A><V><G><L><L><K><A><M><Y><Q><E><L><V><T><F><R><D><V><A><V><D><F><S><Q><E><E><W><D><C><L><D><S><S><Q><R><H><L><Y><S><N><V><M><L><E><N><Y><R><I><L><V><S><L><G><L><C><F><S><K><P><S><V><I><L><L><L><E><Q><G><K><A><P><W><M><V><K><R><E><L><T><K><G><L><C><S><G><W><E><P><I><C><E><T><E><E><L><T><P><K><Q><D><F><Y><E><E><H><Q><S><Q><K><I><I><E><T><L><T><S><Y><N><L><E><Y><S><S><L><R><E><E><W><K><C><E><G><Y><F><E><R><Q><P><G><N><Q><K><A><C><F><K><E><E><I><I><T><H><E><E><P><L><F><D><E><R><E><Q><E><Y><K><S><W><G><S><F><H><Q><N><P><L><L><C><T><Q><K><I><I><P><K><E><E><K><V><H><K><H><D><T><Q><K><R><S><F><K><K><N><L><M><A><I><K><P><K><S><V><C><A><E><K><K><L><L><K><C><N><D><C><E><K><V><F><S><Q><S><S><S><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><K><C><I><E><C><G><K><A><F><S><Q><R><S><N><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><R><K><A><F><S><Q><N><A><H><L><V><Q><H><L><R><V><H><T><G><E><K><P><Y><E><C><K><V><C><R><K><A><F><S><Q><F><A><Y><L><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><S><N><R><S><S><I><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><N><V><C><G><K><A><F><S><L><R><A><Y><L><T><V><H><Q><R><I><H><T><G><E><R><P><Y><E><C><K><E><C><G><K><A><F><S><Q><N><S><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><Q><E><C><R><K><A><F><S><Q><I><A><Y><L><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><S><N><D><S><S><L><T><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><T><V><C><G><K><A><F><S><Y><C><G><S><L><A><Q><H><Q><R><I><H><T><G><E><R><P><Y><E><C><K><E><C><K><K><T><F><R><Q><H><A><H><L><A><H><H><Q><R><I><H><I><G><E><S><L><S><P><P><N><P><V><N><H><Q><V><L> | May be involved in transcriptional regulation.<BOP> | Q96NI8 |
O95861 | BPNT1_HUMAN | PAP-inositol 1,4-phosphatase | Homo | <M><A><S><S><N><T><V><L><M><R><L><V><A><S><A><Y><S><I><A><Q><K><A><G><M><I><V><R><R><V><I><A><E><G><D><L><G><I><V><E><K><T><C><A><T><D><L><Q><T><K><A><D><R><L><A><Q><M><S><I><C><S><S><L><A><R><K><F><P><K><L><T><I><I><G><E><E><D><L><P><S><E><E><V><D><Q><E><L><I><E><D><S><Q><W><E><E><I><L><K><Q><P><C><P><S><Q><Y><S><A><I><K><E><E><D><L><V><V><W><V><D><P><L><D><G><T><K><E><Y><T><E><G><L><L><D><N><V><T><V><L><I><G><I><A><Y><E><G><K><A><I><A><G><V><I><N><Q><P><Y><Y><N><Y><E><A><G><P><D><A><V><L><G><R><T><I><W><G><V><L><G><L><G><A><F><G><F><Q><L><K><E><V><P><A><G><K><H><I><I><T><T><T><R><S><H><S><N><K><L><V><T><D><C><V><A><A><M><N><P><D><A><V><L><R><V><G><G><A><G><N><K><I><I><Q><L><I><E><G><K><A><S><A><Y><V><F><A><S><P><G><C><K><K><W><D><T><C><A><P><E><V><I><L><H><A><V><G><G><K><L><T><D><I><H><G><N><V><L><Q><Y><H><K><D><V><K><H><M><N><S><A><G><V><L><A><T><L><R><N><Y><D><Y><Y><A><S><R><V><P><E><S><I><K><N><A><L><V><P> | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.<BOP> | O95861 |
Q9Y383 | LC7L2_HUMAN | Putative RNA-binding protein Luc7-like 2 | Homo | <M><S><A><Q><A><Q><M><R><A><M><L><D><Q><L><M><G><T><S><R><D><G><D><T><T><R><Q><R><I><K><F><S><D><D><R><V><C><K><S><H><L><L><N><C><C><P><H><D><V><L><S><G><T><R><M><D><L><G><E><C><L><K><V><H><D><L><A><L><R><A><D><Y><E><I><A><S><K><E><Q><D><F><F><F><E><L><D><A><M><D><H><L><Q><S><F><I><A><D><C><D><R><R><T><E><V><A><K><K><R><L><A><E><T><Q><E><E><I><S><A><E><V><A><A><K><A><E><R><V><H><E><L><N><E><E><I><G><K><L><L><A><K><V><E><Q><L><G><A><E><G><N><V><E><E><S><Q><K><V><M><D><E><V><E><K><A><R><A><K><K><R><E><A><E><E><V><Y><R><N><S><M><P><A><S><S><F><Q><Q><Q><K><L><R><V><C><E><V><C><S><A><Y><L><G><L><H><D><N><D><R><R><L><A><D><H><F><G><G><K><L><H><L><G><F><I><E><I><R><E><K><L><E><E><L><K><R><V><V><A><E><K><Q><E><K><R><N><Q><E><R><L><K><R><R><E><E><R><E><R><E><E><R><E><K><L><R><R><S><R><S><H><S><K><N><P><K><R><S><R><S><R><E><H><R><R><H><R><S><R><S><M><S><R><E><R><K><R><R><T><R><S><K><S><R><E><K><R><H><R><H><R><S><R><S><S><S><R><S><R><S><R><S><H><Q><R><S><R><H><S><S><R><D><R><S><R><E><R><S><K><R><R><S><S><K><E><R><F><R><D><Q><D><L><A><S><C><D><R><D><R><S><S><R><D><R><S><P><R><D><R><D><R><K><D><K><K><R><S><Y><E><S><A><N><G><R><S><E><D><R><R><S><S><E><E><R><E><A><G><E><I> | May bind to RNA via its Arg/Ser-rich domain.<BOP> | Q9Y383 |
Q9NZD2 | GLTP_HUMAN | Glycolipid transfer protein | Homo | <M><A><L><L><A><E><H><L><L><K><P><L><P><A><D><K><Q><I><E><T><G><P><F><L><E><A><V><S><H><L><P><P><F><F><D><C><L><G><S><P><V><F><T><P><I><K><A><D><I><S><G><N><I><T><K><I><K><A><V><Y><D><T><N><P><A><K><F><R><T><L><Q><N><I><L><E><V><E><K><E><M><Y><G><A><E><W><P><K><V><G><A><T><L><A><L><M><W><L><K><R><G><L><R><F><I><Q><V><F><L><Q><S><I><C><D><G><E><R><D><E><N><H><P><N><L><I><R><V><N><A><T><K><A><Y><E><M><A><L><K><K><Y><H><G><W><I><V><Q><K><I><F><Q><A><A><L><Y><A><A><P><Y><K><S><D><F><L><K><A><L><S><K><G><Q><N><V><T><E><E><E><C><L><E><K><I><R><L><F><L><V><N><Y><T><A><T><I><D><V><I><Y><E><M><Y><T><Q><M><N><A><E><L><N><Y><K><V> | Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<BOP> | Q9NZD2 |
O00337 | S28A1_HUMAN | Solute carrier family 28 member 1 | Homo | <M><E><N><D><P><S><R><R><R><E><S><I><S><L><T><P><V><A><K><G><L><E><N><M><G><A><D><F><L><E><S><L><E><E><G><Q><L><P><R><S><D><L><S><P><A><E><I><R><S><S><W><S><E><A><A><P><K><P><F><S><R><W><R><N><L><Q><P><A><L><R><A><R><S><F><C><R><E><H><M><Q><L><F><R><W><I><G><T><G><L><L><C><T><G><L><S><A><F><L><L><V><A><C><L><L><D><F><Q><R><A><L><A><L><F><V><L><T><C><V><V><L><T><F><L><G><H><R><L><L><K><R><L><L><G><P><K><L><R><R><F><L><K><P><Q><G><H><P><R><L><L><L><W><F><K><R><G><L><A><L><A><A><F><L><G><L><V><L><W><L><S><L><D><T><S><Q><R><P><E><Q><L><V><S><F><A><G><I><C><V><F><V><A><L><L><F><A><C><S><K><H><H><C><A><V><S><W><R><A><V><S><W><G><L><G><L><Q><F><V><L><G><L><L><V><I><R><T><E><P><G><F><I><A><F><E><W><L><G><E><Q><I><R><I><F><L><S><Y><T><K><A><G><S><S><F><V><F><G><E><A><L><V><K><D><V><F><A><F><Q><V><L><P><I><I><V><F><F><S><C><V><I><S><V><L><Y><H><V><G><L><M><Q><W><V><I><L><K><I><A><W><L><M><Q><V><T><M><G><T><T><A><T><E><T><L><S><V><A><G><N><I><F><V><S><Q><T><E><A><P><L><L><I><R><P><Y><L><A><D><M><T><L><S><E><V><H><V><V><M><T><G><G><Y><A><T><I><A><G><S><L><L><G><A><Y><I><S><F><G><I><D><A><T><S><L><I><A><A><S><V><M><A><A><P><C><A><L><A><L><S><K><L><V><Y><P><E><V><E><E><S><K><F><R><R><E><E><G><V><K><L><T><Y><G><D><A><Q><N><L><I><E><A><A><S><T><G><A><A><I><S><V><K><V><V><A><N><I><A><A><N><L><I><A><F><L><A><V><L><D><F><I><N><A><A><L><S><W><L><G><D><M><V><D><I><Q><G><L><S><F><Q><L><I><C><S><Y><I><L><R><P><V><A><F><L><M><G><V><A><W><E><D><C><P><V><V><A><E><L><L><G><I><K><L><F><L><N><E><F><V><A><Y><Q><D><L><S><K><Y><K><Q><R><R><L><A><G><A><E><E><W><V><G><D><R><K><Q><W><I><S><V><R><A><E><V><L><T><T><F><A><L><C><G><F><A><N><F><S><S><I><G><I><M><L><G><G><L><T><S><M><V><P><Q><R><K><S><D><F><S><Q><I><V><L><R><A><L><F><T><G><A><C><V><S><L><V><N><A><C><M><A><G><I><L><Y><M><P><R><G><A><E><V><D><C><M><S><L><L><N><T><T><L><S><S><S><S><F><E><I><Y><Q><C><C><R><E><A><F><Q><S><V><N><P><E><F><S><P><E><A><L><D><N><C><C><R><F><Y><N><H><T><I><C><A><Q> | Sodium-dependent and pyrimidine-selective transporter . Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine) . Transports uridine, cytidine, thymidine, and nucleoside-derived drugs . Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) . It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS) . It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine .<BOP> | O00337 |
Q96EV8 | DTBP1_HUMAN | Hermansky-Pudlak syndrome 7 protein | Homo | <M><L><E><T><L><R><E><R><L><L><S><V><Q><Q><D><F><T><S><G><L><K><T><L><S><D><K><S><R><E><A><K><V><K><S><K><P><R><T><V><P><F><L><P><K><Y><S><A><G><L><E><L><L><S><R><Y><E><D><T><W><A><A><L><H><R><R><A><K><D><C><A><S><A><G><E><L><V><D><S><E><V><V><M><L><S><A><H><W><E><K><K><K><T><S><L><V><E><L><Q><E><Q><L><Q><Q><L><P><A><L><I><A><D><L><E><S><M><T><A><N><L><T><H><L><E><A><S><F><E><E><V><E><N><N><L><L><H><L><E><D><L><C><G><Q><C><E><L><E><R><C><K><H><M><Q><S><Q><Q><L><E><N><Y><K><K><N><K><R><K><E><L><E><T><F><K><A><E><L><D><A><E><H><A><Q><K><V><L><E><M><E><H><T><Q><Q><M><K><L><K><E><R><Q><K><F><F><E><E><A><F><Q><Q><D><M><E><Q><Y><L><S><T><G><Y><L><Q><I><A><E><R><R><E><P><I><G><S><M><S><S><M><E><V><N><V><D><M><L><E><Q><M><D><L><M><D><I><S><D><Q><E><A><L><D><V><F><L><N><S><G><G><E><E><N><T><V><L><S><P><A><L><G><P><E><S><S><T><C><Q><N><E><I><T><L><Q><V><P><N><P><S><E><L><R><A><K><P><P><S><S><S><S><T><C><T><D><S><A><T><R><D><I><S><E><G><G><E><S><P><V><V><Q><S><D><E><E><E><V><Q><V><D><T><A><L><A><T><S><H><T><D><R><E><A><T><P><D><G><G><E><D><S><D><S> | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.<BOP> | Q96EV8 |
P53794 | SC5A3_HUMAN | Solute carrier family 5 member 3 | Homo | <M><R><A><V><L><D><T><A><D><I><A><I><V><A><L><Y><F><I><L><V><M><C><I><G><F><F><A><M><W><K><S><N><R><S><T><V><S><G><Y><F><L><A><G><R><S><M><T><W><V><A><I><G><A><S><L><F><V><S><N><I><G><S><E><H><F><I><G><L><A><G><S><G><A><A><S><G><F><A><V><G><A><W><E><F><N><A><L><L><L><L><Q><L><L><G><W><V><F><I><P><I><Y><I><R><S><G><V><Y><T><M><P><E><Y><L><S><K><R><F><G><G><H><R><I><Q><V><Y><F><A><A><L><S><L><I><L><Y><I><F><T><K><L><S><V><D><L><Y><S><G><A><L><F><I><Q><E><S><L><G><W><N><L><Y><V><S><V><I><L><L><I><G><M><T><A><L><L><T><V><T><G><G><L><V><A><V><I><Y><T><D><T><L><Q><A><L><L><M><I><I><G><A><L><T><L><M><I><I><S><I><M><E><I><G><G><F><E><E><V><K><R><R><Y><M><L><A><S><P><D><V><T><S><I><L><L><T><Y><N><L><S><N><T><N><S><C><N><V><S><P><K><K><E><A><L><K><M><L><R><N><P><T><D><E><D><V><P><W><P><G><F><I><L><G><Q><T><P><A><S><V><W><Y><W><C><A><D><Q><V><I><V><Q><R><V><L><A><A><K><N><I><A><H><A><K><G><S><T><L><M><A><G><F><L><K><L><L><P><M><F><I><I><V><V><P><G><M><I><S><R><I><L><F><T><D><D><I><A><C><I><N><P><E><H><C><M><L><V><C><G><S><R><A><G><C><S><N><I><A><Y><P><R><L><V><M><K><L><V><P><V><G><L><R><G><L><M><M><A><V><M><I><A><A><L><M><S><D><L><D><S><I><F><N><S><A><S><T><I><F><T><L><D><V><Y><K><L><I><R><K><S><A><S><S><R><E><L><M><I><V><G><R><I><F><V><A><F><M><V><V><I><S><I><A><W><V><P><I><I><V><E><M><Q><G><G><Q><M><Y><L><Y><I><Q><E><V><A><D><Y><L><T><P><P><V><A><A><L><F><L><L><A><I><F><W><K><R><C><N><E><Q><G><A><F><Y><G><G><M><A><G><F><V><L><G><A><V><R><L><I><L><A><F><A><Y><R><A><P><E><C><D><Q><P><D><N><R><P><G><F><I><K><D><I><H><Y><M><Y><V><A><T><G><L><F><W><V><T><G><L><I><T><V><I><V><S><L><L><T><P><P><P><T><K><E><Q><I><R><T><T><T><F><W><S><K><K><N><L><V><V><K><E><N><C><S><P><K><E><E><P><Y><Q><M><Q><E><K><S><I><L><R><C><S><E><N><N><E><T><I><N><H><I><I><P><N><G><K><S><E><D><S><I><K><G><L><Q><P><E><D><V><N><L><L><V><T><C><R><E><E><G><N><P><V><A><S><L><G><H><S><E><A><E><T><P><V><D><A><Y><S><N><G><Q><A><A><L><M><G><E><K><E><R><K><K><E><T><D><D><G><G><R><Y><W><K><F><I><D><W><F><C><G><F><K><S><K><S><L><S><K><R><S><L><R><D><L><M><E><E><E><A><V><C><L><Q><M><L><E><E><T><R><Q><V><K><V><I><L><N><I><G><L><F><A><V><C><S><L><G><I><F><M><F><V><Y><F><S><L> | Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.<BOP> | P53794 |
Q9NQA3 | WASH6_HUMAN | Protein FAM39A | Homo | <M><A><F><H><E><M><Q><A><H><K><N><A><L><G><T><S><G><E><Q><Q><A><A><D><I><T><G><P><T><P><H><Q><G><G><W><K><Q><V><E><Q><S><R><S><Q><V><Q><A><I><G><E><K><V><S><L><A><Q><A><K><I><E><K><I><K><G><S><K><K><A><I><K><V><F><S><S><A><K><Y><P><A><P><E><R><L><Q><E><Y><G><S><I><F><T><G><A><Q><D><P><G><L><Q><R><R><P><R><H><R><I><Q><S><K><H><R><P><L><D><E><R><A><L><Q><E><K><L><K><D><F><P><V><C><V><S><T><K><P><E><P><E><D><D><A><E><E><G><L><G><G><L><P><S><N><I><S><S><V><S><S><L><L><L><F><N><T><T><E><N><L><Y><K><K><Y><V><F><L><D><P><L><A><G><A><V><T><K><T><H><V><M><L><G><A><E><T><E><E><K><L><F><D><A><P><L><S><I><S><K><R><E><Q><L><E><Q><Q><V><P><E><N><Y><F><Y><V><P><D><L><G><Q><V><P><E><I><D><V><P><S><Y><L><P><D><L><P><S><I><A><N><D><L><M><Y><S><A><D><L><G><P><G><I><A><P><S><A><P><G><T><I><P><E><L><P><T><F><H><T><E><V><A><E><P><L><K><A><D><L><Q><D><G><V><L><T><P><P><P><P><P><P><P><P><P><P><A><P><E><V><L><A><S><A><P><P><L><P><P><S><T><A><A><P><V><G><Q><G><A><R><Q><D><D><G><S><S><S><A><S><P><S><V><Q><G><A><P><R><E><V><V><D><P><S><G><G><W><A><T><L><L><E><S><I><R><Q><A><G><G><I><G><K><A><K><L><R><S><M><K><E><R><K><L><E><K><K><K><Q><K><E><Q><E><Q><V><R><A><T><S><Q><G><G><H><L><M><S><D><L><F><N><K><L><V><M><R><R><K><G><I><S><G><K><G><P><G><A><G><E><G><P><G><G><A><F><A><R><V><S><D><S><I><P><P><V><P><P><P><Q><Q><P><Q><A><E><E><D><E><D><D><W><E><S> | May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.<BOP> | Q9NQA3 |
Q5VTL8 | PR38B_HUMAN | Sarcoma antigen NY-SAR-27 | Homo | <M><A><N><N><S><P><A><L><T><G><N><S><Q><P><Q><H><Q><A><A><A><A><A><A><Q><Q><Q><Q><Q><C><G><G><G><G><A><T><K><P><A><V><S><G><K><Q><G><N><V><L><P><L><W><G><N><E><K><T><M><N><L><N><P><M><I><L><T><N><I><L><S><S><P><Y><F><K><V><Q><L><Y><E><L><K><T><Y><H><E><V><V><D><E><I><Y><F><K><V><T><H><V><E><P><W><E><K><G><S><R><K><T><A><G><Q><T><G><M><C><G><G><V><R><G><V><G><T><G><G><I><V><S><T><A><F><C><L><L><Y><K><L><F><T><L><K><L><T><R><K><Q><V><M><G><L><I><T><H><T><D><S><P><Y><I><R><A><L><G><F><M><Y><I><R><Y><T><Q><P><P><T><D><L><W><D><W><F><E><S><F><L><D><D><E><E><D><L><D><V><K><A><G><G><G><C><V><M><T><I><G><E><M><L><R><S><F><L><T><K><L><E><W><F><S><T><L><F><P><R><I><P><V><P><V><Q><K><N><I><D><Q><Q><I><K><T><R><P><R><K><I><K><K><D><G><K><E><G><A><E><E><I><D><R><H><V><E><R><R><R><S><R><S><P><R><R><S><L><S><P><R><R><S><P><R><R><S><R><S><R><S><H><H><R><E><G><H><G><S><S><S><F><D><R><E><L><E><R><E><K><E><R><Q><R><L><E><R><E><A><K><E><R><E><K><E><R><R><R><S><R><S><I><D><R><G><L><E><R><R><R><S><R><S><R><E><R><H><R><S><R><S><R><S><R><D><R><K><G><D><R><R><D><R><D><R><E><R><E><K><E><N><E><R><G><R><R><R><D><R><D><Y><D><K><E><R><G><N><E><R><E><K><E><R><E><R><S><R><E><R><S><K><E><Q><R><S><R><G><E><V><E><E><K><K><H><K><E><D><K><D><D><R><R><H><R><D><D><K><R><D><S><K><K><E><K><K><H><S><R><S><R><S><R><E><R><K><H><R><S><R><S><R><S><R><N><A><G><K><R><S><R><S><R><S><K><E><K><S><S><K><H><K><N><E><S><K><E><K><S><N><K><R><S><R><S><G><S><Q><G><R><T><D><S><V><E><K><S><K><K><R><E><H><S><P><S><K><E><K><S><R><K><R><S><R><S><K><E><R><S><H><K><R><D><H><S><D><S><K><D><Q><S><D><K><H><D><R><R><R><S><Q><S><I><E><Q><E><S><Q><E><K><Q><H><K><N><K><D><E><T><V> | May be required for pre-mRNA splicing.<BOP> | Q5VTL8 |
O75426 | FBX24_HUMAN | F-box only protein 24 | Homo | <M><G><E><K><A><V><P><L><L><R><R><R><R><V><K><R><S><C><P><S><C><G><S><E><L><G><V><E><E><K><R><G><K><G><N><P><I><S><I><Q><L><F><P><P><E><L><V><E><H><I><I><S><F><L><P><V><R><D><L><V><A><L><G><Q><T><C><R><Y><F><H><E><V><C><D><G><E><G><V><W><R><R><I><C><R><R><L><S><P><R><L><Q><D><Q><G><S><G><V><R><P><W><K><R><A><A><I><L><N><Y><T><K><G><L><Y><F><Q><A><F><G><G><R><R><R><C><L><S><K><S><V><A><P><L><L><A><H><G><Y><R><R><F><L><P><T><K><D><H><V><F><I><L><D><Y><V><G><T><L><F><F><L><K><N><A><L><V><S><T><L><G><Q><M><Q><W><K><R><A><C><R><Y><V><V><L><C><R><G><A><K><D><F><A><S><D><P><R><C><D><T><V><Y><R><K><Y><L><Y><V><L><A><T><R><E><P><Q><E><V><V><G><T><T><S><S><R><A><C><D><C><V><E><V><Y><L><Q><S><S><G><Q><R><V><F><K><M><T><F><H><H><S><M><T><F><K><Q><I><V><L><V><G><Q><E><T><Q><R><A><L><L><L><L><T><E><E><G><K><I><Y><S><L><V><V><N><E><T><Q><L><D><Q><P><R><S><Y><T><V><Q><L><A><L><R><K><V><S><H><Y><L><P><H><L><R><V><A><C><M><T><S><N><Q><S><S><T><L><Y><V><T><D><Q><G><G><V><Y><F><E><V><H><T><P><G><V><Y><R><D><L><F><G><T><L><Q><A><F><D><P><L><D><Q><Q><M><P><L><A><L><S><L><P><A><K><I><L><F><C><A><L><G><Y><N><H><L><G><L><V><D><E><F><G><R><I><F><M><Q><G><N><N><R><Y><G><Q><L><G><T><G><D><K><M><D><R><G><E><P><T><Q><V><C><Y><L><Q><R><P><I><T><L><W><C><G><L><N><H><S><L><V><L><S><Q><S><S><E><F><S><K><E><L><L><G><C><G><C><G><A><G><G><R><L><P><G><W><P><K><G><S><A><S><F><V><K><L><Q><V><K><V><P><L><C><A><C><A><L><C><A><T><R><E><C><L><Y><I><L><S><S><H><D><I><E><Q><H><A><P><Y><R><H><L><P><A><S><R><V><V><G><T><P><E><P><S><L><G><A><R><A><P><Q><D><P><G><G><M><A><Q><A><C><E><E><Y><L><S><Q><I><H><S><C><Q><T><L><Q><D><R><T><E><K><M><K><E><I><V><G><W><M><P><L><M><A><A><Q><K><D><F><F><W><E><A><L><D><M><L><Q><R><A><E><G><G><G><G><G><V><G><P><P><A><P><E><T> | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP> | O75426 |
A0A0B4J271 | TVAL3_HUMAN | T cell receptor alpha variable 12-3 | Homo | <M><M><K><S><L><R><V><L><L><V><I><L><W><L><Q><L><S><W><V><W><S><Q><Q><K><E><V><E><Q><D><P><G><P><L><S><V><P><E><G><A><I><V><S><L><N><C><T><Y><S><N><S><A><F><Q><Y><F><M><W><Y><R><Q><Y><S><R><K><G><P><E><L><L><M><Y><T><Y><S><S><G><N><K><E><D><G><R><F><T><A><Q><V><D><K><S><S><K><Y><I><S><L><F><I><R><D><S><Q><P><S><D><S><A><T><Y><L><C><A><M><S> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J271 |
P0C7T2 | OR2T7_HUMAN | olfactory receptor OR1-44 | Homo | <M><P><T><L><S><F><W><V><C><S><A><T><P><V><S><P><G><F><F><A><L><I><L><L><V><F><V><T><S><I><A><S><N><V><V><K><I><I><L><I><H><I><D><S><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><R><D><I><L><Y><I><S><T><I><V><P><K><M><L><V><D><Q><V><M><S><Q><R><A><I><S><F><A><G><C><T><A><Q><H><F><L><Y><L><T><L><A><G><A><E><F><F><L><L><G><L><M><S><C><D><R><Y><V><A><I><C><N><P><L><H><Y><P><D><L><M><S><R><K><I><C><W><L><I><V><A><A><A><W><L><G><G><S><I><D><G><F><L><L><T><P><V><T><M><Q><F><P><F><C><A><S><R><E><I><N><H><F><F><C><E><V><P><A><L><L><K><L><S><C><T><D><T><S><A><Y><E><T><A><M><Y><V><C><C><I><M><M><L><L><I><P><F><S><V><I><S><G><S><Y><T><R><I><L><I><T><V><Y><R><M><S><E><A><E><G><R><R><K><A><V><A><T><C><S><S><H><M><V><V><V><S><L><F><Y><G><A><A><M><Y><T><Y><V><L><P><H><S><Y><H><T><P><E><Q><D><K><A><V><S><A><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><T><G><A><L><Q><K><V><V><G><R><C><V><S><S><G><K><V><T><T><F> | Odorant receptor.<BOP> | P0C7T2 |
O00541 | PESC_HUMAN | Pescadillo homolog | Homo | <M><G><G><L><E><K><K><K><Y><E><R><G><S><A><T><N><Y><I><T><R><N><K><A><R><K><K><L><Q><L><S><L><A><D><F><R><R><L><C><I><L><K><G><I><Y><P><H><E><P><K><H><K><K><K><V><N><K><G><S><T><A><A><R><T><F><Y><L><I><K><D><I><R><F><L><L><H><E><P><I><V><N><K><F><R><E><Y><K><V><F><V><R><K><L><R><K><A><Y><G><K><S><E><W><N><T><V><E><R><L><K><D><N><K><P><N><Y><K><L><D><H><I><I><K><E><R><Y><P><T><F><I><D><A><L><R><D><L><D><D><A><L><S><M><C><F><L><F><S><T><F><P><R><T><G><K><C><H><V><Q><T><I><Q><L><C><R><R><L><T><V><E><F><M><H><Y><I><I><A><A><R><A><L><R><K><V><F><L><S><I><K><G><I><Y><Y><Q><A><E><V><L><G><Q><P><I><V><W><I><T><P><Y><A><F><S><H><D><H><P><T><D><V><D><Y><R><V><M><A><T><F><T><E><F><Y><T><T><L><L><G><F><V><N><F><R><L><Y><Q><L><L><N><L><H><Y><P><P><K><L><E><G><Q><A><Q><A><E><A><K><A><G><E><G><T><Y><A><L><D><S><E><S><C><M><E><K><L><A><A><L><S><A><S><L><A><R><V><V><V><P><A><T><E><E><E><A><E><V><D><E><F><P><T><D><G><E><M><S><A><Q><E><E><D><R><R><K><E><L><E><A><Q><E><K><H><K><K><L><F><E><G><L><K><F><F><L><N><R><E><V><P><R><E><A><L><A><F><I><I><R><S><F><G><G><E><V><S><W><D><K><S><L><C><I><G><A><T><Y><D><V><T><D><S><R><I><T><H><Q><I><V><D><R><P><G><Q><Q><T><S><V><I><G><R><C><Y><V><Q><P><Q><W><V><F><D><S><V><N><A><R><L><L><L><P><V><A><E><Y><F><S><G><V><Q><L><P><P><H><L><S><P><F><V><T><E><K><E><G><D><Y><V><P><P><E><K><L><K><L><L><A><L><Q><R><G><E><D><P><G><N><L><N><E><S><E><E><E><E><E><E><D><D><N><N><E><G><D><G><D><E><E><G><E><N><E><E><E><E><E><D><A><E><A><G><S><E><K><E><E><E><A><R><L><A><A><L><E><E><Q><R><M><E><G><K><K><P><R><V><M><A><G><T><L><K><L><E><D><K><Q><R><L><A><Q><E><E><E><S><E><A><K><R><L><A><I><M><M><M><K><K><R><E><K><Y><L><Y><Q><K><I><M><F><G><K><R><R><K><I><R><E><A><N><K><L><A><E><K><R><K><A><H><D><E><A><V><R><S><E><K><K><A><K><K><A><R><P><E> | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.<BOP> | O00541 |
Q16445 | GBRA6_HUMAN | GABA(A) receptor subunit alpha-6 | Homo | <M><A><S><S><L><P><W><L><C><I><I><L><W><L><E><N><A><L><G><K><L><E><V><E><G><N><F><Y><S><E><N><V><S><R><I><L><D><N><L><L><E><G><Y><D><N><R><L><R><P><G><F><G><G><A><V><T><E><V><K><T><D><I><Y><V><T><S><F><G><P><V><S><D><V><E><M><E><Y><T><M><D><V><F><F><R><Q><T><W><T><D><E><R><L><K><F><G><G><P><T><E><I><L><S><L><N><N><L><M><V><S><K><I><W><T><P><D><T><F><F><R><N><G><K><K><S><I><A><H><N><M><T><T><P><N><K><L><F><R><I><M><Q><N><G><T><I><L><Y><T><M><R><L><T><I><N><A><D><C><P><M><R><L><V><N><F><P><M><D><G><H><A><C><P><L><K><F><G><S><Y><A><Y><P><K><S><E><I><I><Y><T><W><K><K><G><P><L><Y><S><V><E><V><P><E><E><S><S><S><L><L><Q><Y><D><L><I><G><Q><T><V><S><S><E><T><I><K><S><N><T><G><E><Y><V><I><M><T><V><Y><F><H><L><Q><R><K><M><G><Y><F><M><I><Q><I><Y><T><P><C><I><M><T><V><I><L><S><Q><V><S><F><W><I><N><K><E><S><V><P><A><R><T><V><F><G><I><T><T><V><L><T><M><T><T><L><S><I><S><A><R><H><S><L><P><K><V><S><Y><A><T><A><M><D><W><F><I><A><V><C><F><A><F><V><F><S><A><L><I><E><F><A><A><V><N><Y><F><T><N><L><Q><T><Q><K><A><K><R><K><A><Q><F><A><A><P><P><T><V><T><I><S><K><A><T><E><P><L><E><A><E><I><V><L><H><P><D><S><K><Y><H><L><K><K><R><I><T><S><L><S><L><P><I><V><S><S><S><E><A><N><K><V><L><T><R><A><P><I><L><Q><S><T><P><V><T><P><P><P><L><S><P><A><F><G><G><T><S><K><I><D><Q><Y><S><R><I><L><F><P><V><A><F><A><G><F><N><L><V><Y><W><V><V><Y><L><S><K><D><T><M><E><V><S><S><S><V><E> | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP> | Q16445 |
P82980 | RET5_HUMAN | HRBPiso | Homo | <M><P><P><N><L><T><G><Y><Y><R><F><V><S><Q><K><N><M><E><D><Y><L><Q><A><L><N><I><S><L><A><V><R><K><I><A><L><L><L><K><P><D><K><E><I><E><H><Q><G><N><H><M><T><V><R><T><L><S><T><F><R><N><Y><T><V><Q><F><D><V><G><V><E><F><E><E><D><L><R><S><V><D><G><R><K><C><Q><T><I><V><T><W><E><E><E><H><L><V><C><V><Q><K><G><E><V><P><N><R><G><W><R><H><W><L><E><G><E><M><L><Y><L><E><L><T><A><R><D><A><V><C><E><Q><V><F><R><K><V><R> | Intracellular transport of retinol.<BOP> | P82980 |
Q06265 | EXOS9_HUMAN | Polymyositis/scleroderma autoantigen 75 kDa | Homo | <M><K><E><T><P><L><S><N><C><E><R><R><F><L><L><R><A><I><E><E><K><K><R><L><D><G><R><Q><T><Y><D><Y><R><N><I><R><I><S><F><G><T><D><Y><G><C><C><I><V><E><L><G><K><T><R><V><L><G><Q><V><S><C><E><L><V><S><P><K><L><N><R><A><T><E><G><I><L><F><F><N><L><E><L><S><Q><M><A><A><P><A><F><E><P><G><R><Q><S><D><L><L><V><K><L><N><R><L><M><E><R><C><L><R><N><S><K><C><I><D><T><E><S><L><C><V><V><A><G><E><K><V><W><Q><I><R><V><D><L><H><L><L><N><H><D><G><N><I><I><D><A><A><S><I><A><A><I><V><A><L><C><H><F><R><R><P><D><V><S><V><Q><G><D><E><V><T><L><Y><T><P><E><E><R><D><P><V><P><L><S><I><H><H><M><P><I><C><V><S><F><A><F><F><Q><Q><G><T><Y><L><L><V><D><P><N><E><R><E><E><R><V><M><D><G><L><L><V><I><A><M><N><K><H><R><E><I><C><T><I><Q><S><S><G><G><I><M><L><L><K><D><Q><V><L><R><C><S><K><I><A><G><V><K><V><A><E><I><T><E><L><I><L><K><A><L><E><N><D><Q><K><V><R><K><E><G><G><K><F><G><F><A><E><S><I><A><N><Q><R><I><T><A><F><K><M><E><K><A><P><I><D><T><S><D><V><E><E><K><A><E><E><I><I><A><E><A><E><P><P><S><E><V><V><S><T><P><V><L><W><T><P><G><T><A><Q><I><G><E><G><V><E><N><S><W><G><D><L><E><D><S><E><K><E><D><D><E><G><G><G><D><Q><A><I><I><L><D><G><I><K><M><D><T><G><V><E><V><S><D><I><G><S><Q><D><A><P><I><I><L><S><D><S><E><E><E><E><M><I><I><L><E><P><D><K><N><P><K><K><I><R><T><Q><T><T><S><A><K><Q><E><K><A><P><S><K><K><P><V><K><R><R><K><K><K><R><A><A><N> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q06265 |
Q8NGQ4 | O10Q1_HUMAN | Olfactory receptor OR11-233 | Homo | <M><P><V><G><K><L><V><F><N><Q><S><E><P><T><E><F><V><F><R><A><F><T><T><A><T><E><F><Q><V><L><L><F><L><L><F><L><L><L><Y><L><M><I><L><C><G><N><T><A><I><I><W><V><V><C><T><H><S><T><L><R><T><P><M><Y><F><F><L><S><N><L><S><F><L><E><L><C><Y><T><T><V><V><V><P><L><M><L><S><N><I><L><G><A><Q><K><P><I><S><L><A><G><C><G><A><Q><M><F><F><F><V><T><L><G><S><T><D><C><F><L><L><A><I><M><A><Y><D><R><Y><V><A><I><C><H><P><L><H><Y><T><L><I><M><T><R><E><L><C><T><Q><M><L><G><G><A><L><G><L><A><L><F><P><S><L><Q><L><T><A><L><I><F><T><L><P><F><C><G><H><H><Q><E><I><N><H><F><L><C><D><V><P><P><V><L><R><L><A><C><A><D><I><R><V><H><Q><A><V><L><Y><V><V><S><I><L><V><L><T><I><P><F><L><L><I><C><V><S><Y><V><F><I><T><C><A><I><L><S><I><R><S><A><E><G><R><R><R><A><F><S><T><C><S><F><H><L><T><V><V><L><L><Q><Y><G><C><C><S><L><V><Y><L><R><P><R><S><S><T><S><E><D><E><D><S><Q><I><A><L><V><Y><T><F><V><T><P><L><L><N><P><L><L><Y><S><L><R><N><K><D><V><K><G><A><L><R><S><A><I><I><R><K><A><A><S><D><A><N> | Odorant receptor.<BOP> | Q8NGQ4 |
Q5D0E6 | DALD3_HUMAN | DALR anticodon-binding domain-containing protein 3 | Homo | <M><A><T><R><R><L><G><V><G><E><T><L><G><A><L><N><A><A><L><G><P><G><G><P><V><W><I><K><E><T><R><T><R><H><L><R><S><R><D><F><L><A><P><H><R><A><L><Q><A><R><F><D><D><G><Q><V><P><E><H><L><L><H><A><L><A><C><L><Q><G><P><G><V><A><P><V><L><R><C><A><P><T><P><A><G><L><S><L><Q><L><Q><R><S><A><V><F><E><R><V><L><S><A><V><A><A><Y><A><T><P><A><S><P><A><S><L><G><Q><R><V><L><L><H><C><P><A><L><R><S><S><P><C><A><L><R><L><S><Q><L><R><T><V><L><V><A><D><H><L><A><R><A><L><R><A><H><G><V><C><V><R><L><V><P><A><V><R><D><P><H><M><L><T><F><L><Q><Q><L><R><V><D><W><P><A><A><S><E><R><A><S><S><H><T><L><R><S><H><A><L><E><E><L><T><S><A><N><D><G><R><T><L><S><P><G><I><L><G><R><L><C><L><K><E><L><V><E><E><Q><G><R><T><A><G><Y><D><P><N><L><D><N><C><L><V><T><E><D><L><L><S><V><L><A><E><L><Q><E><A><L><W><H><W><P><E><D><S><H><P><G><L><A><G><A><S><D><T><G><T><G><G><C><L><V><V><H><V><V><S><C><E><E><E><F><Q><Q><Q><K><L><D><L><L><W><Q><K><L><V><D><K><A><P><L><R><Q><K><H><L><I><C><G><P><V><K><V><A><G><A><P><G><T><L><M><T><A><P><E><Y><Y><E><F><R><H><T><Q><V><C><K><A><S><A><L><K><H><G><G><D><L><A><Q><D><P><A><W><T><E><I><F><G><V><L><S><V><A><T><I><K><F><E><M><L><S><T><A><P><Q><S><Q><L><F><L><A><L><A><D><S><S><I><S><T><K><G><T><K><S><G><T><F><V><M><Y><N><C><A><R><L><A><T><L><F><E><S><Y><K><C><S><M><E><Q><G><L><Y><P><T><F><P><P><V><S><S><L><D><F><S><L><L><H><D><E><G><E><W><L><L><L><F><N><S><I><L><P><F><P><D><L><L><S><R><T><A><V><L><D><C><T><A><P><G><L><H><I><A><V><R><T><E><M><I><C><K><F><L><V><Q><L><S><M><D><F><S><S><Y><Y><N><R><V><H><I><L><G><E><P><R><P><H><L><F><G><Q><M><F><V><R><L><Q><L><L><R><A><V><R><E><V><L><H><T><G><L><A><M><L><G><L><P><P><L><S><H><I> | Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2A and METTL2B.<BOP> | Q5D0E6 |
Q9BRP8 | PYM1_HUMAN | Protein wibg homolog | Homo | <M><E><A><A><G><S><P><A><A><T><E><T><G><K><Y><I><A><S><T><Q><R><P><D><G><T><W><R><K><Q><R><R><V><K><E><G><Y><V><P><Q><E><E><V><P><V><Y><E><N><K><Y><V><K><F><F><K><S><K><P><E><L><P><P><G><L><S><P><E><A><T><A><P><V><T><P><S><R><P><E><G><G><E><P><G><L><S><K><T><A><K><R><N><L><K><R><K><E><K><R><R><Q><Q><Q><E><K><G><E><A><E><A><L><S><R><T><L><D><K><V><S><L><E><E><T><A><Q><L><P><S><A><P><Q><G><S><R><A><A><P><T><A><A><S><D><Q><P><D><S><A><A><T><T><E><K><A><K><K><I><K><N><L><K><K><K><L><R><Q><V><E><E><L><Q><Q><R><I><Q><A><G><E><V><S><Q><P><S><K><E><Q><L><E><K><L><A><R><R><R><A><L><E><E><E><L><E><D><L><E><L><G><L> | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.<BOP> | Q9BRP8 |
P04733 | MT1F_HUMAN | Metallothionein-IF | Homo | <M><D><P><N><C><S><C><A><A><G><V><S><C><T><C><A><G><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><V><G><C><S><K><C><A><Q><G><C><V><C><K><G><A><S><E><K><C><S><C><C><D> | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP> | P04733 |
P13232 | IL7_HUMAN | Interleukin-7 | Homo | <M><F><H><V><S><F><R><Y><I><F><G><L><P><P><L><I><L><V><L><L><P><V><A><S><S><D><C><D><I><E><G><K><D><G><K><Q><Y><E><S><V><L><M><V><S><I><D><Q><L><L><D><S><M><K><E><I><G><S><N><C><L><N><N><E><F><N><F><F><K><R><H><I><C><D><A><N><K><E><G><M><F><L><F><R><A><A><R><K><L><R><Q><F><L><K><M><N><S><T><G><D><F><D><L><H><L><L><K><V><S><E><G><T><T><I><L><L><N><C><T><G><Q><V><K><G><R><K><P><A><A><L><G><E><A><Q><P><T><K><S><L><E><E><N><K><S><L><K><E><Q><K><K><L><N><D><L><C><F><L><K><R><L><L><Q><E><I><K><T><C><W><N><K><I><L><M><G><T><K><E><H> | Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis . Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG . Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 .<BOP> | P13232 |
Q9H8G2 | CAAP1_HUMAN | Conserved anti-apoptotic protein | Homo | <M><T><G><K><K><S><S><R><E><K><R><R><K><R><S><S><Q><E><A><A><A><A><L><A><A><P><D><I><V><P><A><L><A><S><G><S><S><G><S><T><S><G><C><G><S><A><G><G><C><G><S><V><S><C><C><G><N><A><N><F><S><G><S><V><T><G><G><G><S><G><G><S><C><W><G><G><S><S><V><E><R><S><E><R><R><K><R><R><S><T><D><S><S><S><V><S><G><S><L><Q><Q><E><T><K><Y><I><L><P><T><L><E><K><E><L><F><L><A><E><H><S><D><L><E><E><G><G><L><D><L><T><V><S><L><K><P><V><S><F><Y><I><S><D><K><K><E><M><L><Q><Q><C><F><C><I><I><G><E><K><K><L><Q><K><M><L><P><D><V><L><K><N><C><S><I><E><E><I><K><K><L><C><Q><E><Q><L><E><L><L><S><E><K><K><I><L><K><I><L><E><G><D><N><G><M><D><S><D><M><E><E><E><A><D><D><G><S><K><M><G><S><D><L><V><S><Q><Q><D><I><C><I><D><S><A><S><S><V><R><E><N><K><Q><P><E><G><L><E><L><K><Q><G><K><G><E><D><S><D><V><L><S><I><N><A><D><A><Y><D><S><D><I><E><G><P><C><N><E><E><A><A><A><P><E><A><P><E><N><T><V><Q><S><E><A><G><Q><I><D><D><L><E><K><D><I><E><K><S><V><N><E><I><L><G><L><A><E><S><S><P><N><E><P><K><A><A><T><L><A><V><P><P><P><E><D><V><Q><P><S><A><Q><Q><L><E><L><L><E><L><E><M><R><A><R><A><I><K><A><L><M><K><A><G><D><I><K><K><P><A> | Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.<BOP> | Q9H8G2 |
Q9H0A8 | COMD4_HUMAN | COMM domain-containing protein 4 | Homo | <M><R><F><R><F><C><G><D><L><D><C><P><D><W><V><L><A><E><I><S><T><L><A><K><M><S><S><V><K><L><R><L><L><C><S><Q><V><L><K><E><L><L><G><Q><G><I><D><Y><E><K><I><L><K><L><T><A><D><A><K><F><E><S><G><D><V><K><A><T><V><A><V><L><S><F><I><L><S><S><A><A><K><H><S><V><D><G><E><S><L><S><S><E><L><Q><Q><L><G><L><P><K><E><H><A><A><S><L><C><R><C><Y><E><E><K><Q><S><P><L><Q><K><H><L><R><V><C><S><L><R><M><N><R><L><A><G><V><G><W><R><V><D><Y><T><L><S><S><S><L><L><Q><S><V><E><E><P><M><V><H><L><R><L><E><V><A><A><A><P><G><T><P><A><Q><P><V><A><M><S><L><S><A><D><K><F><Q><V><L><L><A><E><L><K><Q><A><Q><T><L><M><S><S><L><G> | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Down-regulates activation of NF-kappa-B.<BOP> | Q9H0A8 |
Q9NRL3 | STRN4_HUMAN | Zinedin | Homo | <M><M><E><E><R><A><A><A><A><V><A><A><A><A><S><S><C><R><P><L><G><S><G><A><G><P><G><P><T><G><A><A><P><V><S><A><P><A><P><G><P><G><P><A><G><K><G><G><G><G><G><G><S><P><G><P><T><A><G><P><E><P><L><S><L><P><G><I><L><H><F><I><Q><H><E><W><A><R><F><E><A><E><K><A><R><W><E><A><E><R><A><E><L><Q><A><Q><V><A><F><L><Q><G><E><R><K><G><Q><E><N><L><K><T><D><L><V><R><R><I><K><M><L><E><Y><A><L><K><Q><E><R><A><K><Y><H><K><L><K><F><G><T><D><L><N><Q><G><E><K><K><A><D><V><S><E><Q><V><S><N><G><P><V><E><S><V><T><L><E><N><S><P><L><V><W><K><E><G><R><Q><L><L><R><Q><Y><L><E><E><V><G><Y><T><D><T><I><L><D><M><R><S><K><R><V><R><S><L><L><G><R><S><L><E><L><N><G><A><V><E><P><S><E><G><A><P><R><A><P><P><G><P><A><G><L><S><G><G><E><S><L><L><V><K><Q><I><E><E><Q><I><K><R><N><A><A><G><K><D><G><K><E><R><L><G><G><S><V><L><G><Q><I><P><F><L><Q><N><C><E><D><E><D><S><D><E><D><D><E><L><D><S><V><Q><H><K><K><Q><R><V><K><L><P><S><K><A><L><V><P><E><M><E><D><E><D><E><E><D><D><S><E><D><A><I><N><E><F><D><F><L><G><S><G><E><D><G><E><G><A><P><D><P><R><R><C><T><V><D><G><S><P><H><E><L><E><S><R><R><V><K><L><Q><G><I><L><A><D><L><R><D><V><D><G><L><P><P><K><V><T><G><P><P><P><G><T><P><Q><P><R><P><H><E><D><V><F><I><M><D><T><I><G><G><G><E><V><S><L><G><D><L><A><D><L><T><V><T><N><D><N><D><L><S><C><D><L><S><D><S><K><D><A><F><K><K><T><W><N><P><K><F><T><L><R><S><H><Y><D><G><I><R><S><L><A><F><H><H><S><Q><S><A><L><L><T><A><S><E><D><G><T><L><K><L><W><N><L><Q><K><A><V><T><A><K><K><N><A><A><L><D><V><E><P><I><H><A><F><R><A><H><R><G><P><V><L><A><V><A><M><G><S><N><S><E><Y><C><Y><S><G><G><A><D><A><C><I><H><S><W><K><I><P><D><L><S><M><D><P><Y><D><G><Y><D><P><S><V><L><S><H><V><L><E><G><H><G><D><A><V><W><G><L><A><F><S><P><T><S><Q><R><L><A><S><C><S><A><D><G><T><V><R><I><W><D><P><S><S><S><S><P><A><C><L><C><T><F><P><T><A><S><E><H><G><V><P><T><S><V><A><F><T><S><T><E><P><A><H><I><V><A><S><F><R><S><G><D><T><V><L><Y><D><M><E><V><G><S><A><L><L><T><L><E><S><R><G><S><S><G><P><T><Q><I><N><Q><V><V><S><H><P><N><Q><P><L><T><I><T><A><H><D><D><R><G><I><R><F><L><D><N><R><T><G><K><P><V><H><S><M><V><A><H><L><D><A><V><T><C><L><A><V><D><P><N><G><A><F><L><M><S><G><S><H><D><C><S><L><R><L><W><S><L><D><N><K><T><C><V><Q><E><I><T><A><H><R><K><K><H><E><E><A><I><H><A><V><A><C><H><P><S><K><A><L><I><A><S><A><G><A><D><A><L><A><K><V><F><V> | Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.<BOP> | Q9NRL3 |
P02144 | MYG_HUMAN | Myoglobin | Homo | <M><G><L><S><D><G><E><W><Q><L><V><L><N><V><W><G><K><V><E><A><D><I><P><G><H><G><Q><E><V><L><I><R><L><F><K><G><H><P><E><T><L><E><K><F><D><K><F><K><H><L><K><S><E><D><E><M><K><A><S><E><D><L><K><K><H><G><A><T><V><L><T><A><L><G><G><I><L><K><K><K><G><H><H><E><A><E><I><K><P><L><A><Q><S><H><A><T><K><H><K><I><P><V><K><Y><L><E><F><I><S><E><C><I><I><Q><V><L><Q><S><K><H><P><G><D><F><G><A><D><A><Q><G><A><M><N><K><A><L><E><L><F><R><K><D><M><A><S><N><Y><K><E><L><G><F><Q><G> | Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.<BOP> | P02144 |
Q9P0N8 | MARH2_HUMAN | RING-type E3 ubiquitin transferase MARCHF2 | Homo | <M><T><T><G><D><C><C><H><L><P><G><S><L><C><D><C><S><G><S><P><A><F><S><K><V><V><E><A><T><G><L><G><P><P><Q><Y><V><A><Q><V><T><S><R><D><G><R><L><L><S><T><V><I><R><A><L><D><T><P><S><D><G><P><F><C><R><I><C><H><E><G><A><N><G><E><C><L><L><S><P><C><G><C><T><G><T><L><G><A><V><H><K><S><C><L><E><K><W><L><S><S><S><N><T><S><Y><C><E><L><C><H><T><E><F><A><V><E><K><R><P><R><P><L><T><E><W><L><K><D><P><G><P><R><T><E><K><R><T><L><C><C><D><M><V><C><F><L><F><I><T><P><L><A><A><I><S><G><W><L><C><L><R><G><A><Q><D><H><L><R><L><H><S><Q><L><E><A><V><G><L><I><A><L><T><I><A><L><F><T><I><Y><V><L><W><T><L><V><S><F><R><Y><H><C><Q><L><Y><S><E><W><R><K><T><N><Q><K><V><R><L><K><I><R><E><A><D><S><P><E><G><P><Q><H><S><P><L><A><A><G><L><L><K><K><V><A><E><E><T><P><V> | (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway . Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission .<BOP> | Q9P0N8 |
Q9NS84 | CHST7_HUMAN | N-acetylglucosamine 6-O-sulfotransferase 4 | Homo | <M><K><G><R><R><R><R><R><R><E><Y><C><K><F><A><L><L><L><V><L><Y><T><L><V><L><L><L><V><P><S><V><L><D><G><G><R><D><G><D><K><G><A><E><H><C><P><G><L><Q><R><S><L><G><V><W><S><L><E><A><A><A><A><G><E><R><E><Q><G><A><E><A><R><A><A><E><E><G><G><A><N><Q><S><P><R><F><P><S><N><L><S><G><A><V><G><E><A><V><S><R><E><K><Q><H><I><Y><V><H><A><T><W><R><T><G><S><S><F><L><G><E><L><F><N><Q><H><P><D><V><F><Y><L><Y><E><P><M><W><H><L><W><Q><A><L><Y><P><G><D><A><E><S><L><Q><G><A><L><R><D><M><L><R><S><L><F><R><C><D><F><S><V><L><R><L><Y><A><P><P><G><D><P><A><A><R><A><P><D><T><A><N><L><T><T><A><A><L><F><R><W><R><T><N><K><V><I><C><S><P><P><L><C><P><G><A><P><R><A><R><A><E><V><G><L><V><E><D><T><A><C><E><R><S><C><P><P><V><A><I><R><A><L><E><A><E><C><R><K><Y><P><V><V><V><I><K><D><V><R><L><L><D><L><G><V><L><V><P><L><L><R><D><P><G><L><N><L><K><V><V><Q><L><F><R><D><P><R><A><V><H><N><S><R><L><K><S><R><Q><G><L><L><R><E><S><I><Q><V><L><R><T><R><Q><R><G><D><R><F><H><R><V><L><L><A><H><G><V><G><A><R><P><G><G><Q><S><R><A><L><P><A><A><P><R><A><D><F><F><L><T><G><A><L><E><V><I><C><E><A><W><L><R><D><L><L><F><A><R><G><A><P><A><W><L><R><R><R><Y><L><R><L><R><Y><E><D><L><V><R><Q><P><R><A><Q><L><R><R><L><L><R><F><S><G><L><R><A><L><A><A><L><D><A><F><A><L><N><M><T><R><G><A><A><Y><G><A><D><R><P><F><H><L><S><A><R><D><A><R><E><A><V><H><A><W><R><E><R><L><S><R><E><Q><V><R><Q><V><E><A><A><C><A><P><A><M><R><L><L><A><Y><P><R><S><G><E><E><G><D><A><E><Q><P><R><E><G><E><T><P><L><E><M><D><A><D><G><A><T> | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.<BOP> | Q9NS84 |
Q9BQW3 | COE4_HUMAN | Olf-1/EBF-like 4 | Homo | <M><F><P><A><Q><D><A><L><P><R><S><G><L><N><L><K><E><E><P><L><L><P><A><G><L><G><S><V><R><S><W><M><Q><G><A><G><I><L><D><A><S><T><A><A><Q><S><G><V><G><L><A><R><A><H><F><E><K><Q><P><P><S><N><L><R><K><S><N><F><F><H><F><V><L><A><M><Y><D><R><Q><G><Q><P><V><E><V><E><R><T><A><F><I><D><F><V><E><K><D><R><E><P><G><A><E><K><T><N><N><G><I><H><Y><R><L><R><L><V><Y><N><N><G><L><R><T><E><Q><D><L><Y><V><R><L><I><D><S><M><S><K><Q><A><I><I><Y><E><G><Q><D><K><N><P><E><M><C><R><V><L><L><T><H><E><I><M><C><S><R><C><C><D><R><K><S><C><G><N><R><N><E><T><P><S><D><P><V><I><I><D><R><F><F><L><K><F><F><L><K><C><N><Q><N><C><L><K><N><A><G><N><P><R><D><M><R><R><F><Q><V><V><V><S><T><T><V><S><V><D><G><H><V><L><A><V><S><D><N><M><F><V><H><N><N><S><K><H><G><R><R><A><R><R><L><D><P><S><E><A><A><T><P><C><I><K><A><I><S><P><G><E><G><W><T><T><G><G><A><T><V><I><V><I><G><D><N><F><F><D><G><L><Q><V><V><F><G><N><V><L><V><W><S><E><L><I><T><P><H><A><I><R><V><Q><T><P><P><R><H><I><P><G><V><V><E><V><T><L><S><Y><K><S><K><Q><F><C><K><G><C><P><G><R><F><V><Y><T><A><L><N><E><P><T><I><D><Y><G><F><Q><R><L><Q><K><V><I><P><R><H><P><G><D><P><E><R><L><P><K><E><V><L><L><K><R><A><A><D><L><A><E><A><L><Y><G><V><P><G><S><N><Q><E><L><L><L><K><R><A><A><D><V><A><E><A><L><Y><S><T><P><R><A><P><G><P><L><A><P><L><A><P><S><H><P><H><P><A><V><V><G><I><N><A><F><S><S><P><L><A><I><A><V><G><D><A><T><P><G><P><E><P><G><Y><A><R><S><C><S><S><A><S><P><R><G><F><A><P><S><P><G><S><Q><Q><S><G><Y><G><G><G><L><G><A><G><L><G><G><Y><G><A><P><G><V><A><G><L><G><V><P><G><S><P><S><F><L><N><G><S><T><A><T><S><P><F><A><I><M><P><S><S><P><P><L><A><A><A><S><S><M><S><L><P><A><A><A><P><T><T><S><V><F><S><F><S><P><V><N><M><I><S><A><V><K><Q><R><S><A><F><A><P><V><L><R><P><P><S><S><P><P><Q><A><C><P><R><A><H><G><E><G><L><P><D><Q><S><F><E><D><S><D><K><F><H><S><P><A><R><G><L><Q><G><L><A><Y><S> | Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.<BOP> | Q9BQW3 |
P0DP07 | HV431_HUMAN | Immunoglobulin heavy variable 4-31 | Homo | <M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><V><Q><L><Q><E><S><G><P><G><L><V><K><P><S><Q><T><L><S><L><T><C><T><V><S><G><G><S><I><S><S><G><G><Y><Y><W><S><W><I><R><Q><H><P><G><K><G><L><E><W><I><G><Y><I><Y><Y><S><G><S><T><Y><Y><N><P><S><L><K><S><L><V><T><I><S><V><D><T><S><K><N><Q><F><S><L><K><L><S><S><V><T><A><A><D><T><A><V><Y><Y><C><A><R> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P0DP07 |
Q03938 | ZNF90_HUMAN | Zinc finger protein HTF9 | Homo | <M><G><P><L><E><F><R><D><V><A><I><E><F><S><L><E><E><W><H><C><L><D><T><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><H><L><V><F><L><G><I><V><V><T><K><P><D><L><I><T><C><L><E><Q><G><K><K><P><F><T><V><K><R><H><E><M><I><A><K><S><P><V><M><C><F><H><F><A><Q><D><L><C><P><E><Q><S><L><K><D><S><F><Q><K><V><I><V><T><R><Y><E><K><R><E><Y><G><N><L><E><L><K><K><G><C><E><S><V><D><E><G><K><V><H><K><R><G><Y><N><G><L><N><Q><C><L><T><A><T><Q><S><K><V><F><Q><C><D><T><Y><V><K><V><S><H><I><F><S><N><S><N><R><H><K><I><R><D><T><G><K><K><P><F><K><C><I><E><C><G><K><A><F><N><Q><S><S><T><L><A><T><H><K><K><I><H><T><G><E><I><T><C><K><C><E><E><C><G><K><A><F><N><R><S><S><H><L><T><S><H><K><R><I><H><T><G><E><K><R><Y><K><C><E><D><C><G><K><E><L><K><Y><S><S><T><L><T><A><H><K><R><I><H><T><G><E><K><R><Y><K><C><E><D><C><G><K><E><L><K><Y><S><S><T><L><T><A><H><K><R><I><H><T><G><E><K><P><Y><K><C><D><K><C><G><R><A><F><I><S><S><S><I><L><Y><V><H><K><I><S><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><L><S><S><I><L><S><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><R><R><S><L><V><L><R><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><D><K><C><G><K><A><F><I><S><S><S><L><L><Y><K><H><K><I><S><H><S><E><K><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><T><L><T><I><H><K><I><S><H><T><E><E><K><P><Y><K><C><Q><E><C><D><K><V><F><K><R><S><S><A><L><S><T><H><K><I><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><N><L><T><T><H><K><I><S><H><T><E><E><K><L><Y><K><C><Q><E><C><D><K><A><F><K><Y><S><S><A><L><S><T><H><K><I><I><H><S><G><E><N><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><V><L><S><K><H><K><I><I><H><T><G><A><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><Q><L><T><S><H><K><I><S><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><L><S><S><D><L><N><T><H><K><R><I><H><I><G><Q><K><A><Y><I><V><K><N><M><A><N><L> | May be involved in transcriptional regulation.<BOP> | Q03938 |
O43826 | G6PT1_HUMAN | Transformation-related gene 19 protein | Homo | <M><A><A><Q><G><Y><G><Y><Y><R><T><V><I><F><S><A><M><F><G><G><Y><S><L><Y><Y><F><N><R><K><T><F><S><F><V><M><P><S><L><V><E><E><I><P><L><D><K><D><D><L><G><F><I><T><S><S><Q><S><A><A><Y><A><I><S><K><F><V><S><G><V><L><S><D><Q><M><S><A><R><W><L><F><S><S><G><L><L><L><V><G><L><V><N><I><F><F><A><W><S><S><T><V><P><V><F><A><A><L><W><F><L><N><G><L><A><Q><G><L><G><W><P><P><C><G><K><V><L><R><K><W><F><E><P><S><Q><F><G><T><W><W><A><I><L><S><T><S><M><N><L><A><G><G><L><G><P><I><L><A><T><I><L><A><Q><S><Y><S><W><R><S><T><L><A><L><S><G><A><L><C><V><V><V><S><F><L><C><L><L><L><I><H><N><E><P><A><D><V><G><L><R><N><L><D><P><M><P><S><E><G><K><K><G><S><L><K><E><E><S><T><L><Q><E><L><L><L><S><P><Y><L><W><V><L><S><T><G><Y><L><V><V><F><G><V><K><T><C><C><T><D><W><G><Q><F><F><L><I><Q><E><K><G><Q><S><A><L><V><G><S><S><Y><M><S><A><L><E><V><G><G><L><V><G><S><I><A><A><G><Y><L><S><D><R><A><M><A><K><A><G><L><S><N><Y><G><N><P><R><H><G><L><L><L><F><M><M><A><G><M><T><V><S><M><Y><L><F><R><V><T><V><T><S><D><S><P><K><L><W><I><L><V><L><G><A><V><F><G><F><S><S><Y><G><P><I><A><L><F><G><V><I><A><N><E><S><A><P><P><N><L><C><G><T><S><H><A><I><V><G><L><M><A><N><V><G><G><F><L><A><G><L><P><F><S><T><I><A><K><H><Y><S><W><S><T><A><F><W><V><A><E><V><I><C><A><A><S><T><A><A><F><F><L><L><R><N><I><R><T><K><M><G><R><V><S><K><K><A><E> | Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction . Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.<BOP> | O43826 |
Q92847 | GHSR_HUMAN | Ghrelin receptor | Homo | <M><W><N><A><T><P><S><E><E><P><G><F><N><L><T><L><A><D><L><D><W><D><A><S><P><G><N><D><S><L><G><D><E><L><L><Q><L><F><P><A><P><L><L><A><G><V><T><A><T><C><V><A><L><F><V><V><G><I><A><G><N><L><L><T><M><L><V><V><S><R><F><R><E><L><R><T><T><T><N><L><Y><L><S><S><M><A><F><S><D><L><L><I><F><L><C><M><P><L><D><L><V><R><L><W><Q><Y><R><P><W><N><F><G><D><L><L><C><K><L><F><Q><F><V><S><E><S><C><T><Y><A><T><V><L><T><I><T><A><L><S><V><E><R><Y><F><A><I><C><F><P><L><R><A><K><V><V><V><T><K><G><R><V><K><L><V><I><F><V><I><W><A><V><A><F><C><S><A><G><P><I><F><V><L><V><G><V><E><H><E><N><G><T><D><P><W><D><T><N><E><C><R><P><T><E><F><A><V><R><S><G><L><L><T><V><M><V><W><V><S><S><I><F><F><F><L><P><V><F><C><L><T><V><L><Y><S><L><I><G><R><K><L><W><R><R><R><R><G><D><A><V><V><G><A><S><L><R><D><Q><N><H><K><Q><T><V><K><M><L><A><V><V><V><F><A><F><I><L><C><W><L><P><F><H><V><G><R><Y><L><F><S><K><S><F><E><P><G><S><L><E><I><A><Q><I><S><Q><Y><C><N><L><V><S><F><V><L><F><Y><L><S><A><A><I><N><P><I><L><Y><N><I><M><S><K><K><Y><R><V><A><V><F><R><L><L><G><F><E><P><F><S><Q><R><K><L><S><T><L><K><D><E><S><S><R><A><W><T><E><S><S><I><N><T> | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).<BOP> | Q92847 |
P41439 | FOLR3_HUMAN | Folate receptor 3 | Homo | <M><D><M><A><W><Q><M><M><Q><L><L><L><L><A><L><V><T><A><A><G><S><A><Q><P><R><S><A><R><A><R><T><D><L><L><N><V><C><M><N><A><K><H><H><K><T><Q><P><S><P><E><D><E><L><Y><G><Q><C><S><P><W><K><K><N><A><C><C><T><A><S><T><S><Q><E><L><H><K><D><T><S><R><L><Y><N><F><N><W><D><H><C><G><K><M><E><P><T><C><K><R><H><F><I><Q><D><S><C><L><Y><E><C><S><P><N><L><G><P><W><I><R><Q><V><N><Q><S><W><R><K><E><R><I><L><N><V><P><L><C><K><E><D><C><E><R><W><W><E><D><C><R><T><S><Y><T><C><K><S><N><W><H><K><G><W><N><W><T><S><G><I><N><E><C><P><A><G><A><L><C><S><T><F><E><S><Y><F><P><T><P><A><A><L><C><E><G><L><W><S><H><S><F><K><V><S><N><Y><S><R><G><S><G><R><C><I><Q><M><W><F><D><S><A><Q><G><N><P><N><E><E><V><A><K><F><Y><A><A><A><M><N><A><G><A><P><S><R><G><I><I><D><S> | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.<BOP> | P41439 |
Q9P2F9 | ZN319_HUMAN | Zinc finger protein 319 | Homo | <M><S><E><S><W><Q><Q><P><P><Q><T><Q><P><Q><Q><P><Q><P><P><Q><P><Q><H><H><A><E><P><P><P><A><L><A><E><H><T><L><P><P><G><T><A><E><N><P><L><G><C><A><V><Y><G><I><L><L><Q><P><D><P><G><L><Q><P><P><Q><H><A><P><L><Q><A><A><G><E><P><G><P><K><C><G><V><C><G><H><D><L><A><H><L><S><S><P><H><E><H><Q><C><L><A><G><H><D><R><S><F><Q><C><T><Q><C><L><K><I><F><H><Q><A><T><D><L><L><E><H><Q><C><V><Q><A><E><Q><K><P><F><V><C><G><V><C><K><M><G><F><S><L><L><T><S><L><A><Q><H><H><S><S><H><S><G><L><V><K><C><S><I><C><E><K><T><Y><K><P><A><E><A><A><E><P><A><T><T><A><A><P><S><L><P><A><A><P><A><P><S><T><V><T><P><A><E><Q><A><D><K><P><Y><S><C><P><I><C><Q><K><P><F><K><H><L><S><E><L><S><R><H><E><R><I><H><T><G><E><K><P><Y><K><C><T><L><C><D><K><S><F><S><Q><S><S><H><L><V><H><H><K><R><T><H><S><S><E><R><P><Y><K><C><A><V><C><E><K><T><F><K><H><R><S><H><L><V><R><H><M><Y><A><H><S><G><E><H><H><L><F><R><C><N><V><C><E><L><H><F><K><E><S><S><E><L><L><Q><H><P><C><T><P><S><G><E><R><P><F><R><C><G><E><C><Q><K><A><F><K><R><P><S><D><L><R><Q><H><E><R><T><H><S><A><E><R><P><F><K><C><D><L><C><P><M><G><F><K><Q><Q><Y><A><L><M><R><H><R><R><T><H><K><T><E><E><P><F><K><C><G><L><C><E><K><G><F><G><Q><P><S><H><L><L><Y><H><Q><H><V><H><T><L><E><T><L><F><K><C><P><V><C><Q><K><G><F><D><Q><S><A><E><L><L><R><H><K><C><L><P><G><A><A><E><R><P><F><K><C><P><V><C><N><K><A><Y><K><R><A><S><A><L><Q><K><H><Q><L><A><H><C><A><A><A><E><K><P><L><R><C><T><L><C><E><R><R><F><F><S><S><S><E><F><V><Q><H><R><C><D><P><A><R><E><K><P><L><K><C><P><D><C><E><K><R><F><K><Y><A><S><D><L><Q><R><H><R><R><V><H><T><G><E><K><P><Y><K><C><P><N><C><D><K><A><F><K><Q><R><E><H><L><N><K><H><Q><G><V><H><A><R><E><Q><Q><F><K><C><V><W><C><G><E><R><F><L><D><V><A><L><L><Q><E><H><S><A><Q><H><S><A><A><A><A><A><A><E><G><A><Y><Q><V><A><A><C><L><P> | May be involved in transcriptional regulation.<BOP> | Q9P2F9 |
P05060 | SCG1_HUMAN | CCB peptide | Homo | <M><Q><P><T><L><L><L><S><L><L><G><A><V><G><L><A><A><V><N><S><M><P><V><D><N><R><N><H><N><E><G><M><V><T><R><C><I><I><E><V><L><S><N><A><L><S><K><S><S><A><P><P><I><T><P><E><C><R><Q><V><L><K><T><S><R><K><D><V><K><D><K><E><T><T><E><N><E><N><T><K><F><E><V><R><L><L><R><D><P><A><D><A><S><E><A><H><E><S><S><S><R><G><E><A><G><A><P><G><E><E><D><I><Q><G><P><T><K><A><D><T><E><K><W><A><E><G><G><G><H><S><R><E><R><A><D><E><P><Q><W><S><L><Y><P><S><D><S><Q><V><S><E><E><V><K><T><R><H><S><E><K><S><Q><R><E><D><E><E><E><E><E><G><E><N><Y><Q><K><G><E><R><G><E><D><S><S><E><E><K><H><L><E><E><P><G><E><T><Q><N><A><F><L><N><E><R><K><Q><A><S><A><I><K><K><E><E><L><V><A><R><S><E><T><H><A><A><G><H><S><Q><E><K><T><H><S><R><E><K><S><S><Q><E><S><G><E><E><T><G><S><Q><E><N><H><P><Q><E><S><K><G><Q><P><R><S><Q><E><E><S><E><E><G><E><E><D><A><T><S><E><V><D><K><R><R><T><R><P><R><H><H><H><G><R><S><R><P><D><R><S><S><Q><G><G><S><L><P><S><E><E><K><G><H><P><Q><E><E><S><E><E><S><N><V><S><M><A><S><L><G><E><K><R><D><H><H><S><T><H><Y><R><A><S><E><E><E><P><E><Y><G><E><E><I><K><G><Y><P><G><V><Q><A><P><E><D><L><E><W><E><R><Y><R><G><R><G><S><E><E><Y><R><A><P><R><P><Q><S><E><E><S><W><D><E><E><D><K><R><N><Y><P><S><L><E><L><D><K><M><A><H><G><Y><G><E><E><S><E><E><E><R><G><L><E><P><G><K><G><R><H><H><R><G><R><G><G><E><P><R><A><Y><F><M><S><D><T><R><E><E><K><R><F><L><G><E><G><H><H><R><V><Q><E><N><Q><M><D><K><A><R><R><H><P><Q><G><A><W><K><E><L><D><R><N><Y><L><N><Y><G><E><E><G><A><P><G><K><W><Q><Q><Q><G><D><L><Q><D><T><K><E><N><R><E><E><A><R><F><Q><D><K><Q><Y><S><S><H><H><T><A><E><K><R><K><R><L><G><E><L><F><N><P><Y><Y><D><P><L><Q><W><K><S><S><H><F><E><R><R><D><N><M><N><D><N><F><L><E><G><E><E><E><N><E><L><T><L><N><E><K><N><F><F><P><E><Y><N><Y><D><W><W><E><K><K><P><F><S><E><D><V><N><W><G><Y><E><K><R><N><L><A><R><V><P><K><L><D><L><K><R><Q><Y><D><R><V><A><Q><L><D><Q><L><L><H><Y><R><K><K><S><A><E><F><P><D><F><Y><D><S><E><E><P><V><S><T><H><Q><E><A><E><N><E><K><D><R><A><D><Q><T><V><L><T><E><D><E><K><K><E><L><E><N><L><A><A><M><D><L><E><L><Q><K><I><A><E><K><F><S><Q><R><G> | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.<BOP> | P05060 |
Q5T8D3 | ACBD5_HUMAN | Acyl-CoA-binding domain-containing protein 5 | Homo | <M><F><Q><F><H><A><G><S><W><E><S><W><C><C><C><C><L><I><P><A><D><R><P><W><D><R><G><Q><H><W><Q><L><E><M><A><D><T><R><S><V><H><E><T><R><F><E><A><A><V><K><V><I><Q><S><L><P><K><N><G><S><F><Q><P><T><N><E><M><M><L><K><F><Y><S><F><Y><K><Q><A><T><E><G><P><C><K><L><S><R><P><G><F><W><D><P><I><G><R><Y><K><W><D><A><W><S><S><L><G><D><M><T><K><E><E><A><M><I><A><Y><V><E><E><M><K><K><I><I><E><T><M><P><M><T><E><K><V><E><E><L><L><R><V><I><G><P><F><Y><E><I><V><E><D><K><K><S><G><R><S><S><D><I><T><S><V><R><L><E><K><I><S><K><C><L><E><D><L><G><N><V><L><T><S><T><P><N><A><K><T><V><N><G><K><A><E><S><S><D><S><G><A><E><S><E><E><E><E><A><Q><E><E><V><K><G><A><E><Q><S><D><N><D><K><K><M><M><K><K><S><A><D><H><K><N><L><E><V><I><V><T><N><G><Y><D><K><D><G><F><V><Q><D><I><Q><N><D><I><H><A><S><S><S><L><N><G><R><S><T><E><E><V><K><P><I><D><E><N><L><G><Q><T><G><K><S><A><V><C><I><H><Q><D><I><N><D><D><H><V><E><D><V><T><G><I><Q><H><L><T><S><D><S><D><S><E><V><Y><C><D><S><M><E><Q><F><G><Q><E><E><S><L><D><S><F><T><S><N><N><G><P><F><Q><Y><Y><L><G><G><H><S><S><Q><P><M><E><N><S><G><F><R><E><D><I><Q><V><P><P><G><N><G><N><I><G><N><M><Q><V><V><A><V><E><G><K><G><E><V><K><H><G><G><E><D><G><R><N><N><S><G><A><P><H><R><E><K><R><G><G><E><T><D><E><F><S><N><V><R><R><G><R><G><H><R><M><Q><H><L><S><E><G><T><K><G><R><Q><V><G><S><G><G><D><G><E><R><W><G><S><D><R><G><S><R><G><S><L><N><E><Q><I><A><L><V><L><M><R><L><Q><E><D><M><Q><N><V><L><Q><R><L><Q><K><L><E><T><L><T><A><L><Q><A><K><S><S><T><S><T><L><Q><T><A><P><Q><P><T><S><Q><R><P><S><W><W><P><F><E><M><S><P><G><V><L><T><F><A><I><I><W><P><F><I><A><Q><W><L><V><Y><L><Y><Y><Q><R><R><R><R><K><L><N> | Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.<BOP> | Q5T8D3 |
Q8N144 | CXD3_HUMAN | Gap junction chi-1 protein | Homo | <M><G><E><W><A><F><L><G><S><L><L><D><A><V><Q><L><Q><S><P><L><V><G><R><L><W><L><V><V><M><L><I><F><R><I><L><V><L><A><T><V><G><G><A><V><F><E><D><E><Q><E><E><F><V><C><N><T><L><Q><P><G><C><R><Q><T><C><Y><D><R><A><F><P><V><S><H><Y><R><F><W><L><F><H><I><L><L><L><S><A><P><P><V><L><F><V><V><Y><S><M><H><R><A><G><K><E><A><G><G><A><E><A><A><A><Q><C><A><P><G><L><P><E><A><Q><C><A><P><C><A><L><R><A><R><R><A><R><R><C><Y><L><L><S><V><A><L><R><L><L><A><E><L><T><F><L><G><G><Q><A><L><L><Y><G><F><R><V><A><P><H><F><A><C><A><G><P><P><C><P><H><T><V><D><C><F><V><S><R><P><T><E><K><T><V><F><V><L><F><Y><F><A><V><G><L><L><S><A><L><L><S><V><A><E><L><G><H><L><L><W><K><G><R><P><R><A><G><E><R><D><N><R><C><N><R><A><H><E><E><A><Q><K><L><L><P><P><P><P><P><P><P><P><P><P><A><L><P><S><R><R><P><G><P><E><P><C><A><P><P><A><Y><A><H><P><A><P><A><S><L><R><E><C><G><S><G><R><G><K><A><S><P><A><T><G><R><R><D><L><A><I> | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP> | Q8N144 |
P04432 | KVD39_HUMAN | Ig kappa chain V-I region Daudi | Homo | <M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><R><G><A><R><C><D><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><S><I><S><S><Y><L><N><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><A><A><S><S><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><Q><Q><S><Y><S><T><P> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P04432 |
O00330 | ODPX_HUMAN | proX | Homo | <M><A><A><S><W><R><L><G><C><D><P><R><L><L><R><Y><L><V><G><F><P><G><R><R><S><V><G><L><V><K><G><A><L><G><W><S><V><S><R><G><A><N><W><R><W><F><H><S><T><Q><W><L><R><G><D><P><I><K><I><L><M><P><S><L><S><P><T><M><E><E><G><N><I><V><K><W><L><K><K><E><G><E><A><V><S><A><G><D><A><L><C><E><I><E><T><D><K><A><V><V><T><L><D><A><S><D><D><G><I><L><A><K><I><V><V><E><E><G><S><K><N><I><R><L><G><S><L><I><G><L><I><V><E><E><G><E><D><W><K><H><V><E><I><P><K><D><V><G><P><P><P><P><V><S><K><P><S><E><P><R><P><S><P><E><P><Q><I><S><I><P><V><K><K><E><H><I><P><G><T><L><R><F><R><L><S><P><A><A><R><N><I><L><E><K><H><S><L><D><A><S><Q><G><T><A><T><G><P><R><G><I><F><T><K><E><D><A><L><K><L><V><Q><L><K><Q><T><G><K><I><T><E><S><R><P><T><P><A><P><T><A><T><P><T><A><P><S><P><L><Q><A><T><A><G><P><S><Y><P><R><P><V><I><P><P><V><S><T><P><G><Q><P><N><A><V><G><T><F><T><E><I><P><A><S><N><I><R><R><V><I><A><K><R><L><T><E><S><K><S><T><V><P><H><A><Y><A><T><A><D><C><D><L><G><A><V><L><K><V><R><Q><D><L><V><K><D><D><I><K><V><S><V><N><D><F><I><I><K><A><A><A><V><T><L><K><Q><M><P><D><V><N><V><S><W><D><G><E><G><P><K><Q><L><P><F><I><D><I><S><V><A><V><A><T><D><K><G><L><L><T><P><I><I><K><D><A><A><A><K><G><I><Q><E><I><A><D><S><V><K><A><L><S><K><K><A><R><D><G><K><L><L><P><E><E><Y><Q><G><G><S><F><S><I><S><N><L><G><M><F><G><I><D><E><F><T><A><V><I><N><P><P><Q><A><C><I><L><A><V><G><R><F><R><P><V><L><K><L><T><E><D><E><E><G><N><A><K><L><Q><Q><R><Q><L><I><T><V><T><M><S><S><D><S><R><V><V><D><D><E><L><A><T><R><F><L><K><S><F><K><A><N><L><E><N><P><I><R><L><A> | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.<BOP> | O00330 |
P51153 | RAB13_HUMAN | Cell growth-inhibiting gene 4 protein | Homo | <M><A><K><A><Y><D><H><L><F><K><L><L><L><I><G><D><S><G><V><G><K><T><C><L><I><I><R><F><A><E><D><N><F><N><N><T><Y><I><S><T><I><G><I><D><F><K><I><R><T><V><D><I><E><G><K><K><I><K><L><Q><V><W><D><T><A><G><Q><E><R><F><K><T><I><T><T><A><Y><Y><R><G><A><M><G><I><I><L><V><Y><D><I><T><D><E><K><S><F><E><N><I><Q><N><W><M><K><S><I><K><E><N><A><S><A><G><V><E><R><L><L><L><G><N><K><C><D><M><E><A><K><R><K><V><Q><K><E><Q><A><D><K><L><A><R><E><H><G><I><R><F><F><E><T><S><A><K><S><S><M><N><V><D><E><A><F><S><S><L><A><R><D><I><L><L><K><S><G><G><R><R><S><G><N><G><N><K><P><P><S><T><D><L><K><T><C><D><K><K><N><T><N><K><C><S><L><G> | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT | P51153 |
Q8TBX8 | PI42C_HUMAN | Phosphatidylinositol 5-phosphate 4-kinase type II gamma | Homo | <M><A><S><S><S><V><P><P><A><T><V><S><A><A><T><A><G><P><G><P><G><F><G><F><A><S><K><T><K><K><K><H><F><V><Q><Q><K><V><K><V><F><R><A><A><D><P><L><V><G><V><F><L><W><G><V><A><H><S><I><N><E><L><S><Q><V><P><P><P><V><M><L><L><P><D><D><F><K><A><S><S><K><I><K><V><N><N><H><L><F><H><R><E><N><L><P><S><H><F><K><F><K><E><Y><C><P><Q><V><F><R><N><L><R><D><R><F><G><I><D><D><Q><D><Y><L><V><S><L><T><R><N><P><P><S><E><S><E><G><S><D><G><R><F><L><I><S><Y><D><R><T><L><V><I><K><E><V><S><S><E><D><I><A><D><M><H><S><N><L><S><N><Y><H><Q><Y><I><V><K><C><H><G><N><T><L><L><P><Q><F><L><G><M><Y><R><V><S><V><D><N><E><D><S><Y><M><L><V><M><R><N><M><F><S><H><R><L><P><V><H><R><K><Y><D><L><K><G><S><L><V><S><R><E><A><S><D><K><E><K><V><K><E><L><P><T><L><K><D><M><D><F><L><N><K><N><Q><K><V><Y><I><G><E><E><E><K><K><I><F><L><E><K><L><K><R><D><V><E><F><L><V><Q><L><K><I><M><D><Y><S><L><L><L><G><I><H><D><I><I><R><G><S><E><P><E><E><E><A><P><V><R><E><D><E><S><E><V><D><G><D><C><S><L><T><G><P><P><A><L><V><G><S><Y><G><T><S><P><E><G><I><G><G><Y><I><H><S><H><R><P><L><G><P><G><E><F><E><S><F><I><D><V><Y><A><I><R><S><A><E><G><A><P><Q><K><E><V><Y><F><M><G><L><I><D><I><L><T><Q><Y><D><A><K><K><K><A><A><H><A><A><K><T><V><K><H><G><A><G><A><E><I><S><T><V><H><P><E><Q><Y><A><K><R><F><L><D><F><I><T><N><I><F><A> | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 .<BOP> | Q8TBX8 |
Q9UPW6 | SATB2_HUMAN | Special AT-rich sequence-binding protein 2 | Homo | <M><E><R><R><S><E><S><P><C><L><R><D><S><P><D><R><R><S><G><S><P><D><V><K><G><P><P><P><V><K><V><A><R><L><E><Q><N><G><S><P><M><G><A><R><G><R><P><N><G><A><V><A><K><A><V><G><G><L><M><I><P><V><F><C><V><V><E><Q><L><D><G><S><L><E><Y><D><N><R><E><E><H><A><E><F><V><L><V><R><K><D><V><L><F><S><Q><L><V><E><T><A><L><L><A><L><G><Y><S><H><S><S><A><A><Q><A><Q><G><I><I><K><L><G><R><W><N><P><L><P><L><S><Y><V><T><D><A><P><D><A><T><V><A><D><M><L><Q><D><V><Y><H><V><V><T><L><K><I><Q><L><Q><S><C><S><K><L><E><D><L><P><A><E><Q><W><N><H><A><T><V><R><N><A><L><K><E><L><L><K><E><M><N><Q><S><T><L><A><K><E><C><P><L><S><Q><S><M><I><S><S><I><V><N><S><T><Y><Y><A><N><V><S><A><T><K><C><Q><E><F><G><R><W><Y><K><K><Y><K><K><I><K><V><E><R><V><E><R><E><N><L><S><D><Y><C><V><L><G><Q><R><P><M><H><L><P><N><M><N><Q><L><A><S><L><G><K><T><N><E><Q><S><P><H><S><Q><I><H><H><S><T><P><I><R><N><Q><V><P><A><L><Q><P><I><M><S><P><G><L><L><S><P><Q><L><S><P><Q><L><V><R><Q><Q><I><A><M><A><H><L><I><N><Q><Q><I><A><V><S><R><L><L><A><H><Q><H><P><Q><A><I><N><Q><Q><F><L><N><H><P><P><I><P><R><A><V><K><P><E><P><T><N><S><S><V><E><V><S><P><D><I><Y><Q><Q><V><R><D><E><L><K><R><A><S><V><S><Q><A><V><F><A><R><V><A><F><N><R><T><Q><G><L><L><S><E><I><L><R><K><E><E><D><P><R><T><A><S><Q><S><L><L><V><N><L><R><A><M><Q><N><F><L><N><L><P><E><V><E><R><D><R><I><Y><Q><D><E><R><E><R><S><M><N><P><N><V><S><M><V><S><S><A><S><S><S><P><S><S><S><R><T><P><Q><A><K><T><S><T><P><T><T><D><L><P><I><K><V><D><G><A><N><I><N><I><T><A><A><I><Y><D><E><I><Q><Q><E><M><K><R><A><K><V><S><Q><A><L><F><A><K><V><A><A><N><K><S><Q><G><W><L><C><E><L><L><R><W><K><E><N><P><S><P><E><N><R><T><L><W><E><N><L><C><T><I><R><R><F><L><N><L><P><Q><H><E><R><D><V><I><Y><E><E><E><S><R><H><H><H><S><E><R><M><Q><H><V><V><Q><L><P><P><E><P><V><Q><V><L><H><R><Q><Q><S><Q><P><A><K><E><S><S><P><P><R><E><E><A><P><P><P><P><P><P><T><E><D><S><C><A><K><K><P><R><S><R><T><K><I><S><L><E><A><L><G><I><L><Q><S><F><I><H><D><V><G><L><Y><P><D><Q><E><A><I><H><T><L><S><A><Q><L><D><L><P><K><H><T><I><I><K><F><F><Q><N><Q><R><Y><H><V><K><H><H><G><K><L><K><E><H><L><G><S><A><V><D><V><A><E><Y><K><D><E><E><L><L><T><E><S><E><E><N><D><S><E><E><G><S><E><E><M><Y><K><V><E><A><E><E><E><N><A><D><K><S><K><A><A><P><A><E><I><D><Q><R> | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.<BOP> | Q9UPW6 |
Q9NWT8 | AKIP_HUMAN | Mitochondrial small ribosomal subunit protein mS38 | Homo | <M><L><L><G><R><L><T><S><Q><L><L><R><A><V><P><W><A><G><G><R><P><P><W><P><V><S><G><V><L><G><S><R><V><C><G><P><L><Y><S><T><S><P><A><G><P><G><R><A><A><S><L><P><R><K><G><A><Q><L><E><L><E><E><M><L><V><P><R><K><M><S><V><S><P><L><E><S><W><L><T><A><R><C><F><L><P><R><L><D><T><G><T><A><G><T><V><A><P><P><Q><S><Y><Q><C><P><P><S><Q><I><G><E><G><A><E><Q><G><D><E><G><V><A><D><A><P><Q><I><Q><C><K><N><V><L><K><I><R><R><R><K><M><N><H><H><K><Y><R><K><L><V><K><K><T><R><F><L><R><R><K><V><Q><E><G><R><L><R><R><K><Q><I><K><F><E><K><D><L><R><R><I><W><L><K><A><G><L><K><E><A><P><E><G><W><Q><T><P><K><I><Y><L><R><G><K> | May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.<BOP> | Q9NWT8 |
P43363 | MAGAA_HUMAN | MAGE-10 antigen | Homo | <M><P><R><A><P><K><R><Q><R><C><M><P><E><E><D><L><Q><S><Q><S><E><T><Q><G><L><E><G><A><Q><A><P><L><A><V><E><E><D><A><S><S><S><T><S><T><S><S><S><F><P><S><S><F><P><S><S><S><S><S><S><S><S><S><C><Y><P><L><I><P><S><T><P><E><E><V><S><A><D><D><E><T><P><N><P><P><Q><S><A><Q><I><A><C><S><S><P><S><V><V><A><S><L><P><L><D><Q><S><D><E><G><S><S><S><Q><K><E><E><S><P><S><T><L><Q><V><L><P><D><S><E><S><L><P><R><S><E><I><D><E><K><V><T><D><L><V><Q><F><L><L><F><K><Y><Q><M><K><E><P><I><T><K><A><E><I><L><E><S><V><I><R><N><Y><E><D><H><F><P><L><L><F><S><E><A><S><E><C><M><L><L><V><F><G><I><D><V><K><E><V><D><P><T><G><H><S><F><V><L><V><T><S><L><G><L><T><Y><D><G><M><L><S><D><V><Q><S><M><P><K><T><G><I><L><I><L><I><L><S><I><V><F><I><E><G><Y><C><T><P><E><E><V><I><W><E><A><L><N><M><M><G><L><Y><D><G><M><E><H><L><I><Y><G><E><P><R><K><L><L><T><Q><D><W><V><Q><E><N><Y><L><E><Y><R><Q><V><P><G><S><D><P><A><R><Y><E><F><L><W><G><P><R><A><H><A><E><I><R><K><M><S><L><L><K><F><L><A><K><V><N><G><S><D><P><R><S><F><P><L><W><Y><E><E><A><L><K><D><E><E><E><R><A><Q><D><R><I><A><T><T><D><D><T><T><A><M><A><S><A><S><S><S><A><T><G><S><F><S><Y><P><E> | Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.<BOP> | P43363 |
Q9H239 | MMP28_HUMAN | Epilysin | Homo | <M><V><A><R><V><G><L><L><L><R><A><L><Q><L><L><L><W><G><H><L><D><A><Q><P><A><E><R><G><G><Q><E><L><R><K><E><A><E><A><F><L><E><K><Y><G><Y><L><N><E><Q><V><P><K><A><P><T><S><T><R><F><S><D><A><I><R><A><F><Q><W><V><S><Q><L><P><V><S><G><V><L><D><R><A><T><L><R><Q><M><T><R><P><R><C><G><V><T><D><T><N><S><Y><A><A><W><A><E><R><I><S><D><L><F><A><R><H><R><T><K><M><R><R><K><K><R><F><A><K><Q><G><N><K><W><Y><K><Q><H><L><S><Y><R><L><V><N><W><P><E><H><L><P><E><P><A><V><R><G><A><V><R><A><A><F><Q><L><W><S><N><V><S><A><L><E><F><W><E><A><P><A><T><G><P><A><D><I><R><L><T><F><F><Q><G><D><H><N><D><G><L><G><N><A><F><D><G><P><G><G><A><L><A><H><A><F><L><P><R><R><G><E><A><H><F><D><Q><D><E><R><W><S><L><S><R><R><R><G><R><N><L><F><V><V><L><A><H><E><I><G><H><T><L><G><L><T><H><S><P><A><P><R><A><L><M><A><P><Y><Y><K><R><L><G><R><D><A><L><L><S><W><D><D><V><L><A><V><Q><S><L><Y><G><K><P><L><G><G><S><V><A><V><Q><L><P><G><K><L><F><T><D><F><E><T><W><D><S><Y><S><P><Q><G><R><R><P><E><T><Q><G><P><K><Y><C><H><S><S><F><D><A><I><T><V><D><R><Q><Q><Q><L><Y><I><F><K><G><S><H><F><W><E><V><A><A><D><G><N><V><S><E><P><R><P><L><Q><E><R><W><V><G><L><P><P><N><I><E><A><A><A><V><S><L><N><D><G><D><F><Y><F><F><K><G><G><R><C><W><R><F><R><G><P><K><P><V><W><G><L><P><Q><L><C><R><A><G><G><L><P><R><H><P><D><A><A><L><F><F><P><P><L><R><R><L><I><L><F><K><G><A><R><Y><Y><V><L><A><R><G><G><L><Q><V><E><P><Y><Y><P><R><S><L><Q><D><W><G><G><I><P><E><E><V><S><G><A><L><P><R><P><D><G><S><I><I><F><F><R><D><D><R><Y><W><R><L><D><Q><A><K><L><Q><A><T><T><S><G><R><W><A><T><E><L><P><W><M><G><C><W><H><A><N><S><G><S><A><L><F> | Can degrade casein. Could play a role in tissues homeostasis and repair.<BOP> | Q9H239 |
P27105 | STOM_HUMAN | Protein 7.2b | Homo | <M><A><E><K><R><H><T><R><D><S><E><A><Q><R><L><P><D><S><F><K><D><S><P><S><K><G><L><G><P><C><G><W><I><L><V><A><F><S><F><L><F><T><V><I><T><F><P><I><S><I><W><M><C><I><K><I><I><K><E><Y><E><R><A><I><I><F><R><L><G><R><I><L><Q><G><G><A><K><G><P><G><L><F><F><I><L><P><C><T><D><S><F><I><K><V><D><M><R><T><I><S><F><D><I><P><P><Q><E><I><L><T><K><D><S><V><T><I><S><V><D><G><V><V><Y><Y><R><V><Q><N><A><T><L><A><V><A><N><I><T><N><A><D><S><A><T><R><L><L><A><Q><T><T><L><R><N><V><L><G><T><K><N><L><S><Q><I><L><S><D><R><E><E><I><A><H><N><M><Q><S><T><L><D><D><A><T><D><A><W><G><I><K><V><E><R><V><E><I><K><D><V><K><L><P><V><Q><L><Q><R><A><M><A><A><E><A><E><A><S><R><E><A><R><A><K><V><I><A><A><E><G><E><M><N><A><S><R><A><L><K><E><A><S><M><V><I><T><E><S><P><A><A><L><Q><L><R><Y><L><Q><T><L><T><T><I><A><A><E><K><N><S><T><I><V><F><P><L><P><I><D><M><L><Q><G><I><I><G><A><K><H><S><H><L><G> | Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.<BOP> | P27105 |
Q7Z7F0 | KHDC4_HUMAN | Pre-mRNA splicing factor protein KHDC4 | Homo | <M><S><A><G><S><A><T><H><P><G><A><G><G><R><R><S><K><W><D><Q><P><A><P><A><P><L><L><F><L><P><P><A><A><P><G><G><E><V><T><S><S><G><G><S><P><G><G><T><T><A><A><P><S><G><A><L><D><A><A><A><A><V><A><A><K><I><N><A><M><L><M><A><K><G><K><L><K><P><T><Q><N><A><S><E><K><L><Q><A><P><G><K><G><L><T><S><N><K><S><K><D><D><L><V><V><A><E><V><E><I><N><D><V><P><L><T><C><R><N><L><L><T><R><G><Q><T><Q><D><E><I><S><R><L><S><G><A><A><V><S><T><R><G><R><F><M><T><T><E><E><K><A><K><V><G><P><G><D><R><P><L><Y><L><H><V><Q><G><Q><T><R><E><L><V><D><R><A><V><N><R><I><K><E><I><I><T><N><G><V><V><K><A><A><T><G><T><S><P><T><F><N><G><A><T><V><T><V><Y><H><Q><P><A><P><I><A><Q><L><S><P><A><V><S><Q><K><P><P><F><Q><S><G><M><H><Y><V><Q><D><K><L><F><V><G><L><E><H><A><V><P><T><F><N><V><K><E><K><V><E><G><P><G><C><S><Y><L><Q><H><I><Q><I><E><T><G><A><K><V><F><L><R><G><K><G><S><G><C><I><E><P><A><S><G><R><E><A><F><E><P><M><Y><I><Y><I><S><H><P><K><P><E><G><L><A><A><A><K><K><L><C><E><N><L><L><Q><T><V><H><A><E><Y><S><R><F><V><N><Q><I><N><T><A><V><P><L><P><G><Y><T><Q><P><S><A><I><S><S><V><P><P><Q><P><P><Y><Y><P><S><N><G><Y><Q><S><G><Y><P><V><V><P><P><P><Q><Q><P><V><Q><P><P><Y><G><V><P><S><I><V><P><P><A><V><S><L><A><P><G><V><L><P><A><L><P><T><G><V><P><P><V><P><T><Q><Y><P><I><T><Q><V><Q><P><P><A><S><T><G><Q><S><P><M><G><G><P><F><I><P><A><A><P><V><K><T><A><L><P><A><G><P><Q><P><Q><P><Q><P><Q><P><P><L><P><S><Q><P><Q><A><Q><K><R><R><F><T><E><E><L><P><D><E><R><E><S><G><L><L><G><Y><Q><H><G><P><I><H><M><T><N><L><G><T><G><F><S><S><Q><N><E><I><E><G><A><G><S><K><P><A><S><S><S><G><K><E><R><E><R><D><R><Q><L><M><P><P><P><A><F><P><V><T><G><I><K><T><E><S><D><E><R><N><G><S><G><T><L><T><G><S><H><D><Y><P><A><K><K><M><K><T><T><E><K><G><F><G><L><V><A><Y><A><A><D><S><S><D><E><E><E><E><H><G><G><H><K><N><A><S><S><F><P><Q><G><W><S><L><G><Y><Q><Y><P><S><S><Q><P><R><A><K><Q><Q><M><P><F><W><M><A><P> | RNA-binding protein involved in pre-mRNA splicing . Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome . Involved in regulating splice site selection . Binds preferentially RNA with A/C rich sequences and poly-C stretches .<BOP> | Q7Z7F0 |
A7MCY6 | TBKB1_HUMAN | TANK-binding kinase 1-binding protein 1 | Homo | <M><E><S><M><F><E><D><D><I><S><I><L><T><Q><E><A><L><G><P><S><E><V><W><L><D><S><P><G><D><P><S><L><G><G><D><M><C><S><A><S><H><F><A><L><I><T><A><Y><G><D><I><K><E><R><L><G><G><L><E><R><E><N><A><T><L><R><R><R><L><K><V><Y><E><I><K><Y><P><L><I><S><D><F><G><E><E><H><G><F><S><L><Y><E><I><K><D><G><S><L><L><E><V><E><K><V><S><L><Q><Q><R><L><N><Q><F><Q><H><E><L><Q><K><N><K><E><Q><E><E><Q><L><G><E><M><I><Q><A><Y><E><K><L><C><V><E><K><S><D><L><E><T><E><L><R><E><M><R><A><L><V><E><T><H><L><R><Q><I><C><G><L><E><Q><Q><L><R><Q><Q><Q><G><L><Q><D><A><A><F><S><N><L><S><P><P><P><A><P><A><P><P><C><T><D><L><D><L><H><Y><L><A><L><R><G><G><S><G><L><S><H><A><G><W><P><G><S><T><P><S><V><S><D><L><E><R><R><R><L><E><E><A><L><E><A><A><Q><G><E><A><R><G><A><Q><L><R><E><E><Q><L><Q><A><E><C><E><R><L><Q><G><E><L><K><Q><L><Q><E><T><R><A><Q><D><L><A><S><N><Q><S><E><R><D><M><A><W><V><K><R><V><G><D><D><Q><V><N><L><A><L><A><Y><T><E><L><T><E><E><L><G><R><L><R><E><L><S><S><L><Q><G><R><I><L><R><T><L><L><Q><E><Q><A><R><S><G><G><Q><R><H><S><P><L><S><Q><R><H><S><P><A><P><Q><C><P><S><P><S><P><P><A><R><A><A><P><P><C><P><P><C><Q><S><P><V><P><Q><R><R><S><P><V><P><P><C><P><S><P><Q><Q><R><R><S><P><A><S><P><S><C><P><S><P><V><P><Q><R><R><S><P><V><P><P><S><C><Q><S><P><S><P><Q><R><R><S><P><V><P><P><S><C><P><A><P><Q><P><R><P><P><P><P><P><P><P><G><E><R><T><L><A><E><R><A><Y><A><K><P><P><S><H><H><V><K><A><G><F><Q><G><R><R><S><Y><S><E><L><A><E><G><A><A><Y><A><G><A><S><P><P><W><L><Q><A><E><A><A><T><L><P><K><P><R><A><Y><G><S><E><L><Y><G><P><G><R><P><L><S><P><R><R><A><F><E><G><I><R><L><R><F><E><K><Q><P><S><E><E><D><E><W><A><V><P><T><S><P><P><S><P><E><V><G><T><I><R><C><A><S><F><C><A><G><F><P><I><P><E><S><P><A><A><T><A><Y><A><H><A><E><H><A><Q><S><W><P><S><I><N><L><L><M><E><T><V><G><S><D><I><R><S><C><P><L><C><Q><L><G><F><P><V><G><Y><P><D><D><A><L><I><K><H><I><D><S><H><L><E><N><S><K><I> | Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.<BOP> | A7MCY6 |
Q06432 | CCG1_HUMAN | Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma | Homo | <M><S><Q><T><K><M><L><K><V><R><V><T><L><F><C><I><L><A><G><I><V><L><A><M><T><A><V><V><T><D><H><W><A><V><L><S><P><H><M><E><H><H><N><T><T><C><E><A><A><H><F><G><L><W><R><I><C><T><K><R><I><P><M><D><D><S><K><T><C><G><P><I><T><L><P><G><E><K><N><C><S><Y><F><R><H><F><N><P><G><E><S><S><E><I><F><E><F><T><T><Q><K><E><Y><S><I><S><A><A><A><I><A><I><F><S><L><G><F><I><I><L><G><S><L><C><V><L><L><S><L><G><K><K><R><D><Y><L><L><R><P><A><S><M><F><Y><A><F><A><G><L><C><I><L><V><S><V><E><V><M><R><Q><S><V><K><R><M><I><D><S><E><D><T><V><W><I><E><Y><Y><Y><S><W><S><F><A><C><A><C><A><A><F><I><L><L><F><L><G><G><L><A><L><L><L><F><S><L><P><R><M><P><R><N><P><W><E><S><C><M><D><A><E><P><E><H> | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.<BOP> | Q06432 |
Q5VYV0 | FOXB2_HUMAN | Forkhead box protein B2 | Homo | <M><P><R><P><G><K><S><S><Y><S><D><Q><K><P><P><Y><S><Y><I><S><L><T><A><M><A><I><Q><H><S><A><E><K><M><L><P><L><S><D><I><Y><K><F><I><M><E><R><F><P><Y><Y><R><E><H><T><Q><R><W><Q><N><S><L><R><H><N><L><S><F><N><D><C><F><I><K><I><P><R><R><P><D><Q><P><G><K><G><S><F><W><A><L><H><P><D><C><G><D><M><F><E><N><G><S><F><L><R><R><R><K><R><F><K><V><L><R><A><D><H><T><H><L><H><A><G><S><T><K><S><A><P><G><A><G><P><G><G><H><L><H><P><H><H><H><H><H><P><H><H><H><H><H><H><H><A><A><A><H><H><H><H><H><H><H><P><P><Q><P><P><P><P><P><P><P><P><P><P><H><M><V><H><Y><F><H><Q><Q><P><P><T><A><P><Q><P><P><P><H><L><P><S><Q><P><P><Q><Q><P><P><Q><Q><S><Q><P><Q><Q><P><S><H><P><G><K><M><Q><E><A><A><A><V><A><A><A><A><A><A><A><A><A><A><A><V><G><S><V><G><R><L><S><Q><F><P><P><Y><G><L><G><S><A><A><A><A><A><A><A><A><A><A><S><T><S><G><F><K><H><P><F><A><I><E><N><I><I><G><R><D><Y><K><G><V><L><Q><A><G><G><L><P><L><A><S><V><M><H><H><L><G><Y><P><V><P><G><Q><L><G><N><V><V><S><S><V><W><P><H><V><G><V><M><D><S><V><A><A><A><A><A><A><A><A><A><A><G><V><P><V><G><P><E><Y><G><A><F><G><V><P><V><K><S><L><C><H><S><A><S><Q><S><L><P><A><M><P><V><P><I><K><P><T><P><A><L><P><P><V><S><A><L><Q><P><G><L><T><V><P><A><A><S><Q><Q><P><P><A><P><S><T><V><C><S><A><A><A><A><S><P><V><A><S><L><L><E><P><T><A><P><T><S><A><E><S><K><G><G><S><L><H><S><V><L><V><H><S> | Transcription factor.<BOP> | Q5VYV0 |
A4GXA9 | EME2_HUMAN | Probable crossover junction endonuclease EME2 | Homo | <M><A><R><V><G><P><G><R><A><G><V><S><C><Q><G><R><G><R><G><R><G><G><S><G><Q><R><R><P><P><T><W><E><I><S><D><S><D><A><E><D><S><A><G><S><E><A><A><A><R><A><R><D><P><A><G><E><R><R><A><A><A><E><A><L><R><L><L><R><P><E><Q><V><L><K><R><L><A><V><C><V><D><T><A><I><L><E><D><A><G><A><D><V><L><M><E><A><L><E><A><L><G><C><E><C><R><I><E><P><Q><R><P><A><R><S><L><R><W><T><R><A><S><P><D><P><C><P><R><S><L><P><P><E><V><W><A><A><G><E><Q><E><L><L><L><L><L><E><P><E><E><F><L><Q><G><V><A><T><L><T><Q><I><S><G><P><T><H><W><V><P><W><I><S><P><E><T><T><A><R><P><H><L><A><V><I><G><L><D><A><Y><L><W><S><R><Q><H><V><S><R><G><T><Q><Q><P><E><S><P><K><V><A><G><A><E><V><A><V><S><W><P><E><V><E><E><A><L><V><L><L><Q><L><W><A><N><L><D><V><L><L><V><A><S><W><Q><E><L><S><R><H><V><C><A><V><T><K><A><L><A><Q><Y><P><L><K><Q><Y><R><E><S><Q><A><F><S><F><C><T><A><G><R><W><A><A><G><E><P><V><A><R><D><G><A><G><L><Q><A><A><W><R><R><Q><I><R><Q><F><S><R><V><S><P><A><V><A><D><A><V><V><T><A><F><P><S><P><R><L><L><Q><Q><A><L><E><A><C><S><T><E><R><E><R><M><G><L><L><A><D><L><P><V><P><P><S><E><G><G><R><P><R><R><V><G><P><D><L><S><R><R><I><C><L><F><L><T><T><A><N><P><D><L><L><L><D><L><G><S> | Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.<BOP> | A4GXA9 |
Q66PJ3 | AR6P4_HUMAN | Splicing factor SRrp37 | Homo | <M><A><H><V><G><S><R><K><R><S><R><S><R><S><R><S><R><G><R><G><S><E><K><R><K><K><K><S><R><K><D><T><S><R><N><C><S><A><S><T><S><Q><G><R><K><A><S><T><A><P><G><A><E><A><S><P><S><P><C><I><T><E><R><S><K><Q><K><A><R><R><R><T><R><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><D><G><R><K><K><R><G><K><Y><K><D><K><R><R><K><K><K><K><K><R><K><K><L><K><K><K><G><K><E><K><A><E><A><Q><Q><V><E><A><L><P><G><P><S><L><D><Q><W><H><R><S><A><G><E><E><E><D><G><P><V><L><T><D><E><Q><K><S><R><I><Q><A><M><K><P><M><T><K><E><E><W><D><A><R><Q><S><I><I><R><K><V><V><D><P><E><T><G><R><T><R><L><I><K><G><D><G><E><V><L><E><E><I><V><T><K><E><R><H><R><E><I><N><K><Q><A><T><R><G><D><C><L><A><F><Q><M><R><A><G><L><L><P> | Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.<BOP> | Q66PJ3 |
P58166 | INHBE_HUMAN | Activin beta-E chain | Homo | <M><R><L><P><D><V><Q><L><W><L><V><L><L><W><A><L><V><R><A><Q><G><T><G><S><V><C><P><S><C><G><G><S><K><L><A><P><Q><A><E><R><A><L><V><L><E><L><A><K><Q><Q><I><L><D><G><L><H><L><T><S><R><P><R><I><T><H><P><P><P><Q><A><A><L><T><R><A><L><R><R><L><Q><P><G><S><V><A><P><G><N><G><E><E><V><I><S><F><A><T><V><T><D><S><T><S><A><Y><S><S><L><L><T><F><H><L><S><T><P><R><S><H><H><L><Y><H><A><R><L><W><L><H><V><L><P><T><L><P><G><T><L><C><L><R><I><F><R><W><G><P><R><R><R><R><Q><G><S><R><T><L><L><A><E><H><H><I><T><N><L><G><W><H><T><L><T><L><P><S><S><G><L><R><G><E><K><S><G><V><L><K><L><Q><L><D><C><R><P><L><E><G><N><S><T><V><T><G><Q><P><R><R><L><L><D><T><A><G><H><Q><Q><P><F><L><E><L><K><I><R><A><N><E><P><G><A><G><R><A><R><R><R><T><P><T><C><E><P><A><T><P><L><C><C><R><R><D><H><Y><V><D><F><Q><E><L><G><W><R><D><W><I><L><Q><P><E><G><Y><Q><L><N><Y><C><S><G><Q><C><P><P><H><L><A><G><S><P><G><I><A><A><S><F><H><S><A><V><F><S><L><L><K><A><N><N><P><W><P><A><S><T><S><C><C><V><P><T><A><R><R><P><L><S><L><L><Y><L><D><H><N><G><N><V><V><K><T><D><V><P><D><M><V><V><E><A><C><G><C><S> | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.<BOP> | P58166 |
A6NFK2 | GRCR2_HUMAN | Glutaredoxin domain-containing cysteine-rich protein 1-like protein | Homo | <M><E><D><P><E><K><K><L><N><Q><K><S><D><G><K><P><R><K><V><R><F><K><I><S><S><S><Y><S><G><R><V><L><K><Q><V><F><E><D><G><Q><E><L><E><S><P><K><E><E><Y><P><H><S><F><L><Q><E><S><L><E><T><M><D><G><V><Y><G><S><G><E><V><P><R><P><Q><M><C><S><P><K><L><T><A><Q><R><I><S><V><F><R><E><G><N><A><Y><T><L><A><G><G><Q><P><R><F><N><D><Y><K><A><N><D><H><K><P><L><P><I><I><D><F><G><K><I><I><I><Y><T><N><N><L><K><I><I><R><T><P><M><D><K><R><D><F><V><R><K><I><L><Q><K><E><E><E><A><E><E><E><S><L><M><N><K><E><E><S><Y><G><G><R><D><Q><H><D><R><P><L><V><E><A><E><S><T><L><P><Q><N><R><Y><T><Q><E><G><D><I><P><E><D><S><C><F><H><C><R><G><S><G><S><A><T><C><S><L><C><H><G><S><K><F><S><M><L><A><N><R><F><K><E><S><Y><R><A><L><R><C><P><A><C><N><E><N><G><L><Q><P><C><Q><I><C><N><Q> | Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.<BOP> | A6NFK2 |
O43502 | RA51C_HUMAN | RAD51-like protein 2 | Homo | <M><R><G><K><T><F><R><F><E><M><Q><R><D><L><V><S><F><P><L><S><P><A><V><R><V><K><L><V><S><A><G><F><Q><T><A><E><E><L><L><E><V><K><P><S><E><L><S><K><E><V><G><I><S><K><A><E><A><L><E><T><L><Q><I><I><R><R><E><C><L><T><N><K><P><R><Y><A><G><T><S><E><S><H><K><K><C><T><A><L><E><L><L><E><Q><E><H><T><Q><G><F><I><I><T><F><C><S><A><L><D><D><I><L><G><G><G><V><P><L><M><K><T><T><E><I><C><G><A><P><G><V><G><K><T><Q><L><C><M><Q><L><A><V><D><V><Q><I><P><E><C><F><G><G><V><A><G><E><A><V><F><I><D><T><E><G><S><F><M><V><D><R><V><V><D><L><A><T><A><C><I><Q><H><L><Q><L><I><A><E><K><H><K><G><E><E><H><R><K><A><L><E><D><F><T><L><D><N><I><L><S><H><I><Y><Y><F><R><C><R><D><Y><T><E><L><L><A><Q><V><Y><L><L><P><D><F><L><S><E><H><S><K><V><R><L><V><I><V><D><G><I><A><F><P><F><R><H><D><L><D><D><L><S><L><R><T><R><L><L><N><G><L><A><Q><Q><M><I><S><L><A><N><N><H><R><L><A><V><I><L><T><N><Q><M><T><T><K><I><D><R><N><Q><A><L><L><V><P><A><L><G><E><S><W><G><H><A><A><T><I><R><L><I><F><H><W><D><R><K><Q><R><L><A><T><L><Y><K><S><P><S><Q><K><E><C><T><V><L><F><Q><I><K><P><Q><G><F><R><D><T><V><V><T><S><A><C><S><L><Q><T><E><G><S><L><S><T><R><K><R><S><R><D><P><E><E><E><L> | Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating | O43502 |
Q8N8R7 | AL14E_HUMAN | ARF7 effector protein | Homo | <M><M><D><P><C><S><V><G><V><Q><L><R><T><T><N><E><C><H><K><T><Y><Y><T><R><H><T><G><F><K><T><L><Q><E><L><S><S><N><D><M><L><L><L><Q><L><R><T><G><M><T><L><S><G><N><N><T><I><C><F><H><H><V><K><I><Y><I><D><R><F><E><D><L><Q><K><S><C><C><D><P><F><N><I><H><K><K><L><A><K><K><N><L><H><V><I><D><L><D><D><A><T><F><L><S><A><K><F><G><R><Q><L><V><P><G><W><K><L><C><P><K><C><T><Q><I><I><N><G><S><V><D><V><D><T><E><D><R><Q><K><R><K><P><E><S><D><G><R><T><A><K><A><L><R><S><L><Q><F><T><N><P><G><R><Q><T><E><F><A><P><E><T><G><K><R><E><K><R><R><L><T><K><N><A><T><A><G><S><D><R><Q><V><I><P><A><K><S><K><V><Y><D><S><Q><G><L><L><I><F><S><G><M><D><L><C><D><C><L><D><E><D><C><L><G><C><F><Y><A><C><P><A><C><G><S><T><K><C><G><A><E><C><R><C><D><R><K><W><L><Y><E><Q><I><E><I><E><G><G><E><I><I><H><N><K><H><A><G> | Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.<BOP> | Q8N8R7 |
Q9UKV5 | AMFR_HUMAN | gp78 | Homo | <M><P><L><L><F><L><E><R><F><P><W><P><S><L><R><T><Y><T><G><L><S><G><L><A><L><L><G><T><I><I><S><A><Y><R><A><L><S><Q><P><E><A><G><P><G><E><P><D><Q><L><T><A><S><L><Q><P><E><P><P><A><P><A><R><P><S><A><G><G><P><R><A><R><D><V><A><Q><Y><L><L><S><D><S><L><F><V><W><V><L><V><N><T><A><C><C><V><L><M><L><V><A><K><L><I><Q><C><I><V><F><G><P><L><R><V><S><E><R><Q><H><L><K><D><K><F><W><N><F><I><F><Y><K><F><I><F><I><F><G><V><L><N><V><Q><T><V><E><E><V><V><M><W><C><L><W><F><A><G><L><V><F><L><H><L><M><V><Q><L><C><K><D><R><F><E><Y><L><S><F><S><P><T><T><P><M><S><S><H><G><R><V><L><S><L><L><V><A><M><L><L><S><C><C><G><L><A><A><V><C><S><I><T><G><Y><T><H><G><M><H><T><L><A><F><M><A><A><E><S><L><L><V><T><V><R><T><A><H><V><I><L><R><Y><V><I><H><L><W><D><L><N><H><E><G><T><W><E><G><K><G><T><Y><V><Y><Y><T><D><F><V><M><E><L><T><L><L><S><L><D><L><M><H><H><I><H><M><L><L><F><G><N><I><W><L><S><M><A><S><L><V><I><F><M><Q><L><R><Y><L><F><H><E><V><Q><R><R><I><R><R><H><K><N><Y><L><R><V><V><G><N><M><E><A><R><F><A><V><A><T><P><E><E><L><A><V><N><N><D><D><C><A><I><C><W><D><S><M><Q><A><A><R><K><L><P><C><G><H><L><F><H><N><S><C><L><R><S><W><L><E><Q><D><T><S><C><P><T><C><R><M><S><L><N><I><A><D><N><N><R><V><R><E><E><H><Q><G><E><N><L><D><E><N><L><V><P><V><A><A><A><E><G><R><P><R><L><N><Q><H><N><H><F><F><H><F><D><G><S><R><I><A><S><W><L><P><S><F><S><V><E><V><M><H><T><T><N><I><L><G><I><T><Q><A><S><N><S><Q><L><N><A><M><A><H><Q><I><Q><E><M><F><P><Q><V><P><Y><H><L><V><L><Q><D><L><Q><L><T><R><S><V><E><I><T><T><D><N><I><L><E><G><R><I><Q><V><P><F><P><T><Q><R><S><D><S><I><R><P><A><L><N><S><P><V><E><R><P><S><S><D><Q><E><E><G><E><T><S><A><Q><T><E><R><V><P><L><D><L><S><P><R><L><E><E><T><L><D><F><G><E><V><E><V><E><P><S><E><V><E><D><F><E><A><R><G><S><R><F><S><K><S><A><D><E><R><Q><R><M><L><V><Q><R><K><D><E><L><L><Q><Q><A><R><K><R><F><L><N><K><S><S><E><D><D><A><A><S><E><S><F><L><P><S><E><G><A><S><S><D><P><V><T><L><R><R><R><M><L><A><A><A><A><E><R><R><L><Q><K><Q><Q><T><S> | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation . Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) . The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane . In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination . The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction . In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyub | Q9UKV5 |
P20142 | PEPC_HUMAN | Pepsinogen C | Homo | <M><K><W><M><V><V><V><L><V><C><L><Q><L><L><E><A><A><V><V><K><V><P><L><K><K><F><K><S><I><R><E><T><M><K><E><K><G><L><L><G><E><F><L><R><T><H><K><Y><D><P><A><W><K><Y><R><F><G><D><L><S><V><T><Y><E><P><M><A><Y><M><D><A><A><Y><F><G><E><I><S><I><G><T><P><P><Q><N><F><L><V><L><F><D><T><G><S><S><N><L><W><V><P><S><V><Y><C><Q><S><Q><A><C><T><S><H><S><R><F><N><P><S><E><S><S><T><Y><S><T><N><G><Q><T><F><S><L><Q><Y><G><S><G><S><L><T><G><F><F><G><Y><D><T><L><T><V><Q><S><I><Q><V><P><N><Q><E><F><G><L><S><E><N><E><P><G><T><N><F><V><Y><A><Q><F><D><G><I><M><G><L><A><Y><P><A><L><S><V><D><E><A><T><T><A><M><Q><G><M><V><Q><E><G><A><L><T><S><P><V><F><S><V><Y><L><S><N><Q><Q><G><S><S><G><G><A><V><V><F><G><G><V><D><S><S><L><Y><T><G><Q><I><Y><W><A><P><V><T><Q><E><L><Y><W><Q><I><G><I><E><E><F><L><I><G><G><Q><A><S><G><W><C><S><E><G><C><Q><A><I><V><D><T><G><T><S><L><L><T><V><P><Q><Q><Y><M><S><A><L><L><Q><A><T><G><A><Q><E><D><E><Y><G><Q><F><L><V><N><C><N><S><I><Q><N><L><P><S><L><T><F><I><I><N><G><V><E><F><P><L><P><P><S><S><Y><I><L><S><N><N><G><Y><C><T><V><G><V><E><P><T><Y><L><S><S><Q><N><G><Q><P><L><W><I><L><G><D><V><F><L><R><S><Y><Y><S><V><Y><D><L><G><N><N><R><V><G><F><A><T><A><A> | Hydrolyzes a variety of proteins.<BOP> | P20142 |
Q5T4T1 | T170B_HUMAN | Transmembrane protein 170B | Homo | <M><K><A><E><G><G><D><H><S><M><I><N><L><S><V><Q><Q><V><L><S><L><W><A><H><G><T><V><L><R><N><L><T><E><M><W><Y><W><I><F><L><W><A><L><F><S><S><L><F><V><H><G><A><A><G><V><L><M><F><V><M><L><Q><R><H><R><Q><G><R><V><I><S><V><I><A><V><S><I><G><F><L><A><S><V><T><G><A><M><I><T><S><A><A><V><A><G><I><Y><R><V><A><G><K><N><M><A><P><L><E><A><L><V><W><G><V><G><Q><T><V><L><T><L><I><I><S><F><S><R><I><L><A><T><L> | Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets .<BOP> | Q5T4T1 |
P40197 | GPV_HUMAN | Glycoprotein 5 | Homo | <M><L><R><G><T><L><L><C><A><V><L><G><L><L><R><A><Q><P><F><P><C><P><P><A><C><K><C><V><F><R><D><A><A><Q><C><S><G><G><D><V><A><R><I><S><A><L><G><L><P><T><N><L><T><H><I><L><L><F><G><M><G><R><G><V><L><Q><S><Q><S><F><S><G><M><T><V><L><Q><R><L><M><I><S><D><S><H><I><S><A><V><A><P><G><T><F><S><D><L><I><K><L><K><T><L><R><L><S><R><N><K><I><T><H><L><P><G><A><L><L><D><K><M><V><L><L><E><Q><L><F><L><D><H><N><A><L><R><G><I><D><Q><N><M><F><Q><K><L><V><N><L><Q><E><L><A><L><N><Q><N><Q><L><D><F><L><P><A><S><L><F><T><N><L><E><N><L><K><L><L><D><L><S><G><N><N><L><T><H><L><P><K><G><L><L><G><A><Q><A><K><L><E><R><L><L><L><H><S><N><R><L><V><S><L><D><S><G><L><L><N><S><L><G><A><L><T><E><L><Q><F><H><R><N><H><I><R><S><I><A><P><G><A><F><D><R><L><P><N><L><S><S><L><T><L><S><R><N><H><L><A><F><L><P><S><A><L><F><L><H><S><H><N><L><T><L><L><T><L><F><E><N><P><L><A><E><L><P><G><V><L><F><G><E><M><G><G><L><Q><E><L><W><L><N><R><T><Q><L><R><T><L><P><A><A><A><F><R><N><L><S><R><L><R><Y><L><G><V><T><L><S><P><R><L><S><A><L><P><Q><G><A><F><Q><G><L><G><E><L><Q><V><L><A><L><H><S><N><G><L><T><A><L><P><D><G><L><L><R><G><L><G><K><L><R><Q><V><S><L><R><R><N><R><L><R><A><L><P><R><A><L><F><R><N><L><S><S><L><E><S><V><Q><L><D><H><N><Q><L><E><T><L><P><G><D><V><F><G><A><L><P><R><L><T><E><V><L><L><G><H><N><S><W><R><C><D><C><G><L><G><P><F><L><G><W><L><R><Q><H><L><G><L><V><G><G><E><E><P><P><R><C><A><G><P><G><A><H><A><G><L><P><L><W><A><L><P><G><G><D><A><E><C><P><G><P><R><G><P><P><P><R><P><A><A><D><S><S><S><E><A><P><V><H><P><A><L><A><P><N><S><S><E><P><W><V><W><A><Q><P><V><T><T><G><K><G><Q><D><H><S><P><F><W><G><F><Y><F><L><L><L><A><V><Q><A><M><I><T><V><I><I><V><F><A><M><I><K><I><G><Q><L><F><R><K><L><I><R><E><R><A><L><G> | The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.<BOP> | P40197 |
Q9UI43 | MRM2_HUMAN | Protein ftsJ homolog 2 | Homo | <M><A><G><Y><L><K><L><V><C><V><S><F><Q><R><Q><G><F><H><T><V><G><S><R><C><K><N><R><T><G><A><E><H><L><W><L><T><R><H><L><R><D><P><F><V><K><A><A><K><V><E><S><Y><R><C><R><S><A><F><K><L><L><E><V><N><E><R><H><Q><I><L><R><P><G><L><R><V><L><D><C><G><A><A><P><G><A><W><S><Q><V><A><V><Q><K><V><N><A><A><G><T><D><P><S><S><P><V><G><F><V><L><G><V><D><L><L><H><I><F><P><L><E><G><A><T><F><L><C><P><A><D><V><T><D><P><R><T><S><Q><R><I><L><E><V><L><P><G><R><R><A><D><V><I><L><S><D><M><A><P><N><A><T><G><F><R><D><L><D><H><D><R><L><I><S><L><C><L><T><L><L><S><V><T><P><D><I><L><Q><P><G><G><T><F><L><C><K><T><W><A><G><S><Q><S><R><R><L><Q><R><R><L><T><E><E><F><Q><N><V><R><I><I><K><P><E><A><S><R><K><E><S><S><E><V><Y><F><L><A><T><Q><Y><H><G><R><K><G><T><V><K><Q> | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.<BOP> | Q9UI43 |
Q6IA69 | NADE_HUMAN | NAD(+) synthetase | Homo | <M><G><R><K><V><T><V><A><T><C><A><L><N><Q><W><A><L><D><F><E><G><N><L><Q><R><I><L><K><S><I><E><I><A><K><N><R><G><A><R><Y><R><L><G><P><E><L><E><I><C><G><Y><G><C><W><D><H><Y><Y><E><S><D><T><L><L><H><S><F><Q><V><L><A><A><L><V><E><S><P><V><T><Q><D><I><I><C><D><V><G><M><P><V><M><H><R><N><V><R><Y><N><C><R><V><I><F><L><N><R><K><I><L><L><I><R><P><K><M><A><L><A><N><E><G><N><Y><R><E><L><R><W><F><T><P><W><S><R><S><R><H><T><E><E><Y><F><L><P><R><M><I><Q><D><L><T><K><Q><E><T><V><P><F><G><D><A><V><L><V><T><W><D><T><C><I><G><S><E><I><C><E><E><L><W><T><P><H><S><P><H><I><D><M><G><L><D><G><V><E><I><I><T><N><A><S><G><S><H><Q><V><L><R><K><A><N><T><R><V><D><L><V><T><M><V><T><S><K><N><G><G><I><Y><L><L><A><N><Q><K><G><C><D><G><D><R><L><Y><Y><D><G><C><A><M><I><A><M><N><G><S><V><F><A><Q><G><S><Q><F><S><L><D><D><V><E><V><L><T><A><T><L><D><L><E><D><V><R><S><Y><R><A><E><I><S><S><R><N><L><A><A><S><R><A><S><P><Y><P><R><V><K><V><D><F><A><L><S><C><H><E><D><L><L><A><P><I><S><E><P><I><E><W><K><Y><H><S><P><E><E><E><I><S><L><G><P><A><C><W><L><W><D><F><L><R><R><S><Q><Q><A><G><F><L><L><P><L><S><G><G><V><D><S><A><A><T><A><C><L><I><Y><S><M><C><C><Q><V><C><E><A><V><R><S><G><N><E><E><V><L><A><D><V><R><T><I><V><N><Q><I><S><Y><T><P><Q><D><P><R><D><L><C><G><R><I><L><T><T><C><Y><M><A><S><K><N><S><S><Q><E><T><C><T><R><A><R><E><L><A><Q><Q><I><G><S><H><H><I><S><L><N><I><D><P><A><V><K><A><V><M><G><I><F><S><L><V><T><G><K><S><P><L><F><A><A><H><G><G><S><S><R><E><N><L><A><L><Q><N><V><Q><A><R><I><R><M><V><L><A><Y><L><F><A><Q><L><S><L><W><S><R><G><V><H><G><G><L><L><V><L><G><S><A><N><V><D><E><S><L><L><G><Y><L><T><K><Y><D><C><S><S><A><D><I><N><P><I><G><G><I><S><K><T><D><L><R><A><F><V><Q><F><C><I><Q><R><F><Q><L><P><A><L><Q><S><I><L><L><A><P><A><T><A><E><L><E><P><L><A><D><G><Q><V><S><Q><T><D><E><E><D><M><G><M><T><Y><A><E><L><S><V><Y><G><K><L><R><K><V><A><K><M><G><P><Y><S><M><F><C><K><L><L><G><M><W><R><H><I><C><T><P><R><Q><V><A><D><K><V><K><R><F><F><S><K><Y><S><M><N><R><H><K><M><T><T><L><T><P><A><Y><H><A><E><N><Y><S><P><E><D><N><R><F><D><L><R><P><F><L><Y><N><T><S><W><P><W><Q><F><R><C><I><E><N><Q><V><L><Q><L><E><R><A><E><P><Q><S><L><D><G><V><D> | Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.<BOP> | Q6IA69 |
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