accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q5JTW2 | CEP78_HUMAN | Centrosomal protein of 78 kDa | Homo | <M><I><D><S><V><K><L><R><R><D><S><A><A><D><F><F><S><H><Y><E><Y><L><C><A><L><Q><N><S><V><P><L><P><A><V><R><A><C><L><R><E><G><V><L><D><F><N><A><D><R><L><R><G><V><D><W><A><P><L><L><S><T><L><K><I><N><K><D><L><P><L><V><S><I><K><S><F><F><Q><P><W><L><G><D><T><G><S><D><M><N><K><F><C><R><S><R><V><P><A><I><R><Y><K><D><V><T><F><Q><L><C><K><A><L><K><G><C><L><S><I><S><S><V><L><K><N><L><E><L><N><G><L><I><L><R><E><R><D><L><T><I><L><A><K><G><L><N><K><S><A><S><L><V><H><L><S><L><A><N><C><P><I><G><D><G><G><L><E><I><I><C><Q><G><I><K><S><S><I><T><L><K><T><V><N><F><T><G><C><N><L><T><W><Q><G><A><D><H><M><A><K><I><L><K><Y><Q><T><M><R><R><H><E><E><T><W><A><E><S><L><R><Y><R><R><P><D><L><D><C><M><A><G><L><R><R><I><T><L><N><C><N><T><L><I><G><D><L><G><A><C><A><F><A><D><S><L><S><E><D><L><W><L><R><A><L><D><L><Q><Q><C><G><L><T><N><E><G><A><K><A><L><L><E><A><L><E><T><N><T><T><L><V><V><L><D><I><R><K><N><P><L><I><D><H><S><M><M><K><A><V><I><K><K><V><L><Q><N><G><R><S><A><K><S><E><Y><Q><W><I><T><S><P><S><V><K><E><P><S><K><T><A><K><Q><K><R><R><T><I><I><L><G><S><G><H><K><G><K><A><T><I><R><I><G><L><A><T><K><K><P><V><S><S><G><R><K><H><S><L><G><K><E><Y><Y><A><P><A><P><L><P><P><G><V><S><G><F><L><P><W><R><T><A><E><R><A><K><R><H><R><G><F><P><L><I><K><T><R><D><I><C><N><Q><L><Q><Q><P><G><F><P><V><T><V><T><V><E><S><P><S><S><S><E><V><E><E><V><D><D><S><S><E><S><V><H><E><V><P><E><K><T><S><I><E><Q><E><A><L><Q><E><K><L><E><E><C><L><K><Q><L><K><E><E><R><V><I><R><L><K><V><D><K><R><V><S><E><L><E><H><E><N><A><Q><L><R><N><I><N><F><S><L><S><E><A><L><H><A><Q><S><L><T><N><M><I><L><D><D><E><G><V><L><G><S><I><E><N><S><F><Q><K><F><H><A><F><L><D><L><L><K><D><A><G><L><G><Q><L><A><T><M><A><G><I><D><Q><S><D><F><Q><L><L><G><H><P><Q><M><T><S><T><V><S><N><P><P><K><E><E><K><K><A><L><E><D><E><K><P><E><P><K><Q><N><A><L><G><Q><M><Q><N><I><Q><F><Q><K><I><T><G><D><A><R><I><P><L><P><L><D><S><F><P><V><P><V><S><T><P><E><G><L><G><T><S><S><N><N><L><G><V><P><A><T><E><Q><R><Q><E><S><F><E><G><F><I><A><R><M><C><S><P><S><P><D><A><T><S><G><T><G><S><Q><R><K><E><E><E><L><S><R><N><S><R><S><S><S><E><K><K><T><K><T><E><S><H> | May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles . May play a role in cilium biogenesis .<BOP> | Q5JTW2 |
O94766 | B3GA3_HUMAN | UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase | Homo | <M><K><L><K><L><K><N><V><F><L><A><Y><F><L><V><S><I><A><G><L><L><Y><A><L><V><Q><L><G><Q><P><C><D><C><L><P><P><L><R><A><A><A><E><Q><L><R><Q><K><D><L><R><I><S><Q><L><Q><A><E><L><R><R><P><P><P><A><P><A><Q><P><P><E><P><E><A><L><P><T><I><Y><V><V><T><P><T><Y><A><R><L><V><Q><K><A><E><L><V><R><L><S><Q><T><L><S><L><V><P><R><L><H><W><L><L><V><E><D><A><E><G><P><T><P><L><V><S><G><L><L><A><A><S><G><L><L><F><T><H><L><V><V><L><T><P><K><A><Q><R><L><R><E><G><E><P><G><W><V><H><P><R><G><V><E><Q><R><N><K><A><L><D><W><L><R><G><R><G><G><A><V><G><G><E><K><D><P><P><P><P><G><T><Q><G><V><V><Y><F><A><D><D><D><N><T><Y><S><R><E><L><F><E><E><M><R><W><T><R><G><V><S><V><W><P><V><G><L><V><G><G><L><R><F><E><G><P><Q><V><Q><D><G><R><V><V><G><F><H><T><A><W><E><P><S><R><P><F><P><V><D><M><A><G><F><A><V><A><L><P><L><L><L><D><K><P><N><A><Q><F><D><S><T><A><P><R><G><H><L><E><S><S><L><L><S><H><L><V><D><P><K><D><L><E><P><R><A><A><N><C><T><R><V><L><V><W><H><T><R><T><E><K><P><K><M><K><Q><E><E><Q><L><Q><R><Q><G><R><G><S><D><P><A><I><E><V> | Glycosaminoglycans biosynthesis . Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation .<BOP> | O94766 |
P58417 | NXPH1_HUMAN | Neurexophilin-1 | Homo | <M><Q><A><A><C><W><Y><V><L><F><L><L><Q><P><T><V><Y><L><V><T><C><A><N><L><T><N><G><G><K><S><E><L><L><K><S><G><S><S><K><S><T><L><K><H><I><W><T><E><S><S><K><D><L><S><I><S><R><L><L><S><Q><T><F><R><G><K><E><N><D><T><D><L><D><L><R><Y><D><T><P><E><P><Y><S><E><Q><D><L><W><D><W><L><R><N><S><T><D><L><Q><E><P><R><P><R><A><K><R><R><P><I><V><K><T><G><K><F><K><K><M><F><G><W><G><D><F><H><S><N><I><K><T><V><K><L><N><L><L><I><T><G><K><I><V><D><H><G><N><G><T><F><S><V><Y><F><R><H><N><S><T><G><Q><G><N><V><S><V><S><L><V><P><P><T><K><I><V><E><F><D><L><A><Q><Q><T><V><I><D><A><K><D><S><K><S><F><N><C><R><I><E><Y><E><K><V><D><K><A><T><K><N><T><L><C><N><Y><D><P><S><K><T><C><Y><Q><E><Q><T><Q><S><H><V><S><W><L><C><S><K><P><F><K><V><I><C><I><Y><I><S><F><Y><S><T><D><Y><K><L><V><Q><K><V><C><P><D><Y><N><Y><H><S><D><T><P><Y><F><P><S><G> | May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.<BOP> | P58417 |
Q96KR4 | LMLN_HUMAN | Invadolysin | Homo | <M><V><T><T><L><G><P><K><M><A><A><E><W><G><G><G><V><G><Y><S><G><S><G><P><G><R><S><R><W><R><W><S><G><S><V><W><V><R><S><V><L><L><L><L><G><G><L><R><A><S><A><T><S><T><P><V><S><L><G><S><S><P><P><C><R><H><H><V><P><S><D><T><E><V><I><N><K><V><H><L><K><A><N><H><V><V><K><R><D><V><D><E><H><L><R><I><K><T><V><Y><D><K><S><V><E><E><L><L><P><E><K><K><N><L><V><K><N><K><L><F><P><Q><A><I><S><Y><L><E><K><T><F><Q><V><R><R><P><A><G><T><I><L><L><S><R><Q><C><A><T><N><Q><Y><L><R><K><E><N><D><P><H><R><Y><C><T><G><E><C><A><A><H><T><K><C><G><P><V><I><V><P><E><E><H><L><Q><Q><C><R><V><Y><R><G><G><K><W><P><H><G><A><V><G><V><P><D><Q><E><G><I><S><D><A><D><F><V><L><Y><V><G><A><L><A><T><E><R><C><S><H><E><N><I><I><S><Y><A><A><Y><C><Q><Q><E><A><N><M><D><R><P><I><A><G><Y><A><N><L><C><P><N><M><I><S><T><Q><P><Q><E><F><V><G><M><L><S><T><V><K><H><E><V><I><H><A><L><G><F><S><A><G><L><F><A><F><Y><H><D><K><D><G><N><P><L><T><S><R><F><A><D><G><L><P><P><F><N><Y><S><L><G><L><Y><Q><W><S><D><K><V><V><R><K><V><E><R><L><W><D><V><R><D><N><K><I><V><R><H><T><V><Y><L><L><V><T><P><R><V><V><E><E><A><R><K><H><F><D><C><P><V><L><E><G><M><E><L><E><N><Q><G><G><V><G><T><E><L><N><H><W><E><K><R><L><L><E><N><E><A><M><T><G><S><H><T><Q><N><R><V><L><S><R><I><T><L><A><L><M><E><D><T><G><R><Q><M><L><S><P><Y><C><D><T><L><R><S><N><P><L><Q><L><T><C><R><Q><D><Q><R><A><V><A><V><C><N><L><Q><K><F><P><K><P><L><P><Q><E><Y><Q><Y><F><D><E><L><S><G><I><P><A><E><D><L><P><Y><Y><G><G><S><V><E><I><A><D><Y><C><P><F><S><Q><E><F><S><W><H><L><S><G><E><Y><Q><R><S><S><D><C><R><I><L><E><N><Q><P><E><I><F><K><N><Y><G><A><E><K><Y><G><P><H><S><V><C><L><I><Q><K><S><A><F><V><M><E><K><C><E><R><K><L><S><Y><P><D><W><G><S><G><C><Y><Q><V><S><C><S><P><Q><G><L><K><V><W><V><Q><D><T><S><Y><L><C><S><R><A><G><Q><V><L><P><V><S><I><Q><M><N><G><W><I><H><D><G><N><L><L><C><P><S><C><W><D><F><C><E><L><C><P><P><E><T><D><P><P><A><T><N><L><T><R><A><L><P><L><D><L><C><S><C><S><S><S><L><V><V><T><L><W><L><L><L><G><N><L><F><P><L><L><A><G><F><L><L><C><I><W><H> | Metalloprotease.<BOP> | Q96KR4 |
Q5VW38 | GP107_HUMAN | Lung seven transmembrane receptor 1 | Homo | <M><A><A><L><A><P><V><G><S><P><A><S><R><G><P><R><L><A><A><G><L><R><L><L><P><M><L><G><L><L><Q><L><L><A><E><P><G><L><G><R><V><H><H><L><A><L><K><D><D><V><R><H><K><V><H><L><N><T><F><G><F><F><K><D><G><Y><M><V><V><N><V><S><S><L><S><L><N><E><P><E><D><K><D><V><T><I><G><F><S><L><D><R><T><K><N><D><G><F><S><S><Y><L><D><E><D><V><N><Y><C><I><L><K><K><Q><S><V><S><V><T><L><L><I><L><D><I><S><R><S><E><V><R><V><K><S><P><P><E><A><G><T><Q><L><P><K><I><I><F><S><R><D><E><K><V><L><G><Q><S><Q><E><P><N><V><N><P><A><S><A><G><N><Q><T><Q><K><T><Q><D><G><G><K><S><K><R><S><T><V><D><S><K><A><M><G><E><K><S><F><S><V><H><N><N><G><G><A><V><S><F><Q><F><F><F><N><I><S><T><D><D><Q><E><G><L><Y><S><L><Y><F><H><K><C><L><G><K><E><L><P><S><D><K><F><T><F><S><L><D><I><E><I><T><E><K><N><P><D><S><Y><L><S><A><G><E><I><P><L><P><K><L><Y><I><S><M><A><F><F><F><F><L><S><G><T><I><W><I><H><I><L><R><K><R><R><N><D><V><F><K><I><H><W><L><M><A><A><L><P><F><T><K><S><L><S><L><V><F><H><A><I><D><Y><H><Y><I><S><S><Q><G><F><P><I><E><G><W><A><V><V><Y><Y><I><T><H><L><L><K><G><A><L><L><F><I><T><I><A><L><I><G><T><G><W><A><F><I><K><H><I><L><S><D><K><D><K><K><I><F><M><I><V><I><P><L><Q><V><L><A><N><V><A><Y><I><I><I><E><S><T><E><E><G><T><T><E><Y><G><L><W><K><D><S><L><F><L><V><D><L><L><C><C><G><A><I><L><F><P><V><V><W><S><I><R><H><L><Q><E><A><S><A><T><D><G><K><G><D><S><M><G><P><L><Q><Q><R><A><N><L><R><A><G><S><R><I><E><S><H><H><F><A><Q><A><D><L><E><L><L><A><S><S><C><P><P><A><S><V><S><Q><R><A><G><I><T><A><A><I><N><L><A><K><L><K><L><F><R><H><Y><Y><V><L><I><V><C><Y><I><Y><F><T><R><I><I><A><F><L><L><K><L><A><V><P><F><Q><W><K><W><L><Y><Q><L><L><D><E><T><A><T><L><V><F><F><V><L><T><G><Y><K><F><R><P><A><S><D><N><P><Y><L><Q><L><S><Q><E><E><E><D><L><E><M><E><S><V><V><T><T><S><G><V><M><E><S><M><K><K><V><K><K><V><T><N><G><S><V><E><P><Q><G><E><W><E><G><A><V> | (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.<BOP> | Q5VW38 |
Q8NH55 | O52E5_HUMAN | Olfactory receptor 52E5 | Homo | <M><L><H><T><N><N><T><Q><F><H><P><S><T><F><L><V><V><G><V><P><G><L><E><D><V><H><V><W><I><G><F><P><F><F><A><V><Y><L><T><A><L><L><G><N><I><I><I><L><F><V><I><Q><T><E><Q><S><L><H><Q><P><M><F><Y><F><L><A><M><L><A><G><T><D><L><G><L><S><T><A><T><I><P><K><M><L><G><I><F><W><F><N><L><G><E><I><A><F><G><A><C><I><T><Q><M><Y><T><I><H><I><C><T><G><L><E><S><V><V><L><T><V><T><G><I><D><R><Y><I><A><I><C><N><P><L><R><Y><S><M><I><L><T><N><K><V><I><A><I><L><G><I><V><I><I><V><R><T><L><V><F><V><T><P><F><T><F><L><I><L><R><L><P><F><C><G><V><R><I><I><P><H><T><Y><C><E><H><M><G><L><A><K><L><A><C><A><S><I><N><V><I><Y><G><L><I><A><F><S><V><G><Y><I><D><I><S><V><I><G><F><S><Y><V><Q><I><L><R><A><V><F><H><L><P><A><W><D><A><R><P><K><A><L><S><T><C><G><S><H><V><C><V><M><L><A><F><Y><L><P><A><L><F><S><F><M><T><H><R><F><G><H><N><I><P><H><Y><I><H><I><L><L><A><N><L><Y><V><V><F><P><P><A><L><N><S><V><I><Y><G><V><K><T><K><Q><I><R><E><Q><V><L><R><I><L><N><P><K><S><F><W><H><F><D><P><K><R><I><F><H><N><N><S><V><R><Q> | Odorant receptor.<BOP> | Q8NH55 |
Q8NI29 | FBX27_HUMAN | F-box/G-domain protein 5 | Homo | <M><G><A><S><V><S><R><G><R><A><A><R><V><P><A><P><E><P><E><P><E><E><A><L><D><L><S><Q><L><P><P><E><L><L><L><V><V><L><S><H><V><P><P><R><T><L><L><G><R><C><R><Q><V><C><R><G><W><R><A><L><V><D><G><Q><A><L><W><L><L><I><L><A><R><D><H><G><A><T><G><R><A><L><L><H><L><A><R><S><C><Q><S><P><A><R><N><A><R><P><C><P><L><G><R><F><C><A><R><R><P><I><G><R><N><L><I><R><N><P><C><G><Q><E><G><L><R><K><W><M><V><Q><H><G><G><D><G><W><V><V><E><E><N><R><T><T><V><P><G><A><P><S><Q><T><C><F><V><T><S><F><S><W><C><C><K><K><Q><V><L><D><L><E><E><E><G><L><W><P><E><L><L><D><S><G><R><I><E><I><C><V><S><D><W><W><G><A><R><H><D><S><G><C><M><Y><R><L><L><V><Q><L><L><D><A><N><Q><T><V><L><D><K><F><S><A><V><P><D><P><I><P><Q><W><N><N><N><A><C><L><H><V><T><H><V><F><S><N><I><K><M><G><V><R><F><V><S><F><E><H><R><G><Q><D><T><Q><F><W><A><G><H><Y><G><A><R><V><T><N><S><S><V><I><V><R><V><R><L><S> | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.<BOP> | Q8NI29 |
Q9H307 | PININ_HUMAN | SR-like protein | Homo | <M><A><V><A><V><R><T><L><Q><E><Q><L><E><K><A><K><E><S><L><K><N><V><D><E><N><I><R><K><L><T><G><R><D><P><N><D><V><R><P><I><Q><A><R><L><L><A><L><S><G><P><G><G><G><R><G><R><G><S><L><L><L><R><R><G><F><S><D><S><G><G><G><P><P><A><K><Q><R><D><L><E><G><A><V><S><R><L><G><G><E><R><R><T><R><R><E><S><R><Q><E><S><D><P><E><D><D><D><V><K><K><P><A><L><Q><S><S><V><V><A><T><S><K><E><R><T><R><R><D><L><I><Q><D><Q><N><M><D><E><K><G><K><Q><R><N><R><R><I><F><G><L><L><M><G><T><L><Q><K><F><K><Q><E><S><T><V><A><T><E><R><Q><K><R><R><Q><E><I><E><Q><K><L><E><V><Q><A><E><E><E><R><K><Q><V><E><N><E><R><R><E><L><F><E><E><R><R><A><K><Q><T><E><L><R><L><L><E><Q><K><V><E><L><A><Q><L><Q><E><E><W><N><E><H><N><A><K><I><I><K><Y><I><R><T><K><T><K><P><H><L><F><Y><I><P><G><R><M><C><P><A><T><Q><K><L><I><E><E><S><Q><R><K><M><N><A><L><F><E><G><R><R><I><E><F><A><E><Q><I><N><K><M><E><A><R><P><R><R><Q><S><M><K><E><K><E><H><Q><V><V><R><N><E><E><Q><K><A><E><Q><E><E><G><K><V><A><Q><R><E><E><E><L><E><E><T><G><N><Q><H><N><D><V><E><I><E><E><A><G><E><E><E><E><K><E><I><A><I><V><H><S><D><A><E><K><E><Q><E><E><E><E><Q><K><Q><E><M><E><V><K><M><E><E><E><T><E><V><R><E><S><E><K><Q><Q><D><S><Q><P><E><E><V><M><D><V><L><E><M><V><E><N><V><K><H><V><I><A><D><Q><E><V><M><E><T><N><R><V><E><S><V><E><P><S><E><N><E><A><S><K><E><L><E><P><E><M><E><F><E><I><E><P><D><K><E><C><K><T><L><S><P><G><K><E><N><V><S><A><L><D><M><E><K><E><S><E><E><K><E><E><K><E><S><E><P><Q><P><E><P><V><A><Q><P><Q><P><Q><S><Q><P><Q><L><Q><L><Q><S><Q><S><Q><P><V><L><Q><S><Q><P><P><S><Q><P><E><D><L><S><L><A><V><L><Q><P><T><P><Q><V><T><Q><E><Q><G><H><L><L><P><E><R><K><D><F><P><V><E><S><V><K><L><T><E><V><P><V><E><P><V><L><T><V><H><P><E><S><K><S><K><T><K><T><R><S><R><S><R><G><R><A><R><N><K><T><S><K><S><R><S><R><S><S><S><S><S><S><S><S><S><S><S><T><S><S><S><S><G><S><S><S><S><S><G><S><S><S><S><R><S><S><S><S><S><S><S><S><T><S><G><S><S><S><R><D><S><S><S><S><T><S><S><S><S><E><S><R><S><R><S><R><G><R><G><H><N><R><D><R><K><H><R><R><S><V><D><R><K><R><R><D><T><S><G><L><E><R><S><H><K><S><S><K><G><G><S><S><R><D><T><K><G><S><K><D><K><N><S><R><S><D><R><K><R><S><I><S><E><S><S><R><S><G><K><R><S><S><R><S><E><R><D><R><K><S><D><R><K><D><K><R><R> | Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.<BOP> | Q9H307 |
P98187 | CP4F8_HUMAN | CYPIVF8 | Homo | <M><S><L><L><S><L><S><W><L><G><L><R><P><V><A><A><S><P><W><L><L><L><L><V><V><G><A><S><W><L><L><A><R><I><L><A><W><T><Y><A><F><Y><H><N><G><R><R><L><R><C><F><P><Q><P><R><K><Q><N><W><F><L><G><H><L><G><L><V><T><P><T><E><E><G><L><R><V><L><T><Q><L><V><A><T><Y><P><Q><G><F><V><R><W><L><G><P><I><T><P><I><I><N><L><C><H><P><D><I><V><R><S><V><I><N><T><S><D><A><I><T><D><K><D><I><V><F><Y><K><T><L><K><P><W><L><G><D><G><L><L><L><S><V><G><D><K><W><R><H><H><R><R><L><L><T><P><A><F><H><F><N><I><L><K><P><Y><I><K><I><F><S><K><S><A><N><I><M><H><A><K><W><Q><R><L><A><M><E><G><S><T><C><L><D><V><F><E><H><I><S><L><M><T><L><D><S><L><Q><K><C><I><F><S><F><D><S><N><C><Q><E><K><P><S><E><Y><I><T><A><I><M><E><L><S><A><L><V><V><K><R><N><N><Q><F><F><R><Y><K><D><F><L><Y><F><L><T><P><C><G><R><R><F><H><R><A><C><R><L><V><H><D><F><T><D><A><V><I><Q><E><R><R><R><T><L><T><S><Q><G><V><D><D><F><L><Q><A><K><A><K><S><K><T><L><D><F><I><D><V><L><L><L><S><E><D><K><N><G><K><E><L><S><D><E><D><I><R><A><E><A><D><T><F><M><F><G><G><H><D><T><T><A><S><G><L><S><W><V><L><Y><N><L><A><R><H><P><E><Y><Q><E><R><C><R><Q><E><V><Q><E><L><L><K><D><R><E><P><K><E><I><E><W><D><D><L><A><Q><L><P><F><L><T><M><C><L><K><E><S><L><R><L><H><P><P><I><P><T><F><A><R><G><C><T><Q><D><V><V><L><P><D><S><R><V><I><P><K><G><N><V><C><N><I><N><I><F><A><I><H><H><N><P><S><V><W><P><D><P><E><V><Y><D><P><F><R><F><D><P><E><N><A><Q><K><R><S><P><M><A><F><I><P><F><S><A><G><P><R><N><C><I><G><Q><K><F><A><M><A><E><M><K><V><V><L><A><L><T><L><L><R><F><R><I><L><P><D><H><R><E><P><R><R><T><P><E><I><V><L><R><A><E><D><G><L><W><L><R><V><E><P><L><G> | A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions . Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) . Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 . Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids . Shows little activity against PGD2 | P98187 |
Q14CZ0 | HAPR1_HUMAN | Telomere attrition and p53 response 1 protein | Homo | <M><E><E><R><K><E><E><G><E><A><E><I><Q><E><H><G><P><E><H><W><F><S><K><W><E><R><Q><C><L><A><E><A><E><Q><D><E><Q><L><P><P><E><L><Q><E><E><A><A><A><A><A><Q><P><E><H><K><Q><Q><K><L><W><H><L><F><Q><N><S><A><T><A><V><A><Q><L><Y><K><D><R><V><C><Q><Q><P><G><L><S><L><W><V><P><F><Q><N><A><A><T><A><V><T><N><L><Y><K><E><S><V><D><T><H><Q><R><S><F><D><I><G><I><Q><I><G><Y><Q><R><R><N><K><D><V><L><A><W><V><K><K><R><R><R><T><I><R><R><E><D><L><I><S><F><L><C><G><K><V><P><P><P><R><N><S><R><A><P><P><R><L><T><V><V><S><P><N><R><A><T><S><T><E><T><S><S><S><V><E><T><D><L><Q><P><F><R><E><A><I><A><L><H><G><L><S><G><A><M><A><S><I><S><V><R><S><S><T><P><G><S><P><T><H><V><S><S><G><S><N><A><S><R><R><R><N><G><L><H><D><V><D><L><N><T><F><I><S><E><E><M><A><L><H><L><D><N><G><G><T><R><K><R><T><S><A><Q><C><G><D><V><I><T><D><S><P><T><H><K><R><N><R><M><I> | Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage . May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 .<BOP> | Q14CZ0 |
P11844 | CRGA_HUMAN | Gamma-crystallin 5 | Homo | <M><G><K><I><T><F><Y><E><D><R><D><F><Q><G><R><C><Y><N><C><I><S><D><C><P><N><L><R><V><Y><F><S><R><C><N><S><I><R><V><D><S><G><C><W><M><L><Y><E><R><P><N><Y><Q><G><H><Q><Y><F><L><R><R><G><K><Y><P><D><Y><Q><H><W><M><G><L><S><D><S><V><Q><S><C><R><I><I><P><H><T><S><S><H><K><L><R><L><Y><E><R><D><D><Y><R><G><L><M><S><E><L><T><D><D><C><A><C><V><P><E><L><F><R><L><P><E><I><Y><S><L><H><V><L><E><G><C><W><V><L><Y><E><M><P><N><Y><R><G><R><Q><Y><L><L><R><P><G><D><Y><R><R><Y><H><D><W><G><G><A><D><A><K><V><G><S><L><R><R><V><T><D><L><Y> | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> | P11844 |
Q9P255 | ZN492_HUMAN | Zinc finger protein 115 | Homo | <M><L><E><N><Y><R><N><L><V><F><V><G><I><A><A><S><K><P><D><L><I><T><C><L><E><Q><G><K><E><P><W><N><V><K><R><H><E><M><V><A><E><P><P><V><V><C><S><Y><F><A><R><D><L><W><P><K><Q><G><K><K><N><Y><F><Q><K><V><I><L><R><R><Y><K><K><C><G><C><E><N><L><Q><L><R><K><Y><C><K><S><M><D><E><C><K><V><H><K><E><C><Y><N><G><L><N><Q><C><L><T><T><T><Q><N><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><F><S><N><S><N><R><H><T><I><R><H><T><G><K><K><S><F><K><C><K><E><C><E><K><S><F><C><M><L><S><H><L><A><Q><H><K><R><I><H><S><G><E><K><P><Y><K><C><K><E><C><G><K><A><Y><N><E><T><S><N><L><S><T><H><K><R><I><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><L><S><H><L><T><T><H><K><I><I><H><T><G><K><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><A><N><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><R><A><F><S><Q><S><S><T><L><T><A><H><K><I><I><H><A><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><Q><S><S><T><L><T><T><H><K><I><I><H><T><G><E><K><F><Y><K><C><E><E><C><G><K><A><F><S><Q><L><S><H><L><T><T><H><K><R><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><S><S><T><L><T><T><H><K><R><I><H><A><G><E><K><F><Y><K><C><E><V><C><S><K><A><F><S><R><F><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><L><S><S><Q><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><S><K><H><K><V><I><H><T><G><E><K><P><Y><K><Y><E><E><C><G><K><A><F><N><Q><S><S><H><L><T><T><H><K><M><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><N><S><S><I><L><N><R><H><K><M><I><H><T><G><E><K><L><Y><K><P><E><S><C><N><N><A><C><D><N><I><A><K><I><S><K><Y><K><R><N><C><A><G><E><K> | May be involved in transcriptional regulation.<BOP> | Q9P255 |
P17544 | ATF7_HUMAN | Transcription factor ATF-A | Homo | <M><G><D><D><R><P><F><V><C><N><A><P><G><C><G><Q><R><F><T><N><E><D><H><L><A><V><H><K><H><K><H><E><M><T><L><K><F><G><P><A><R><T><D><S><V><I><I><A><D><Q><T><P><T><P><T><R><F><L><K><N><C><E><E><V><G><L><F><N><E><L><A><S><S><F><E><H><E><F><K><K><A><A><D><E><D><E><K><K><A><A><A><G><P><L><D><M><S><L><P><S><T><P><D><I><K><I><K><E><E><E><P><V><E><V><D><S><S><P><P><D><S><P><A><S><S><P><C><S><P><P><L><K><E><K><E><V><T><P><K><P><V><L><I><S><T><P><T><P><T><I><V><R><P><G><S><L><P><L><H><L><G><Y><D><P><L><H><P><T><L><P><S><P><T><S><V><I><T><Q><A><P><P><S><N><R><Q><M><G><S><P><T><G><S><L><P><L><V><M><H><L><A><N><G><Q><T><M><P><V><L><P><G><P><P><V><Q><M><P><S><V><I><S><L><A><R><P><V><S><M><V><P><N><I><P><G><I><P><G><P><P><V><N><S><S><G><S><I><S><P><S><G><H><P><I><P><S><E><A><K><M><R><L><K><A><T><L><T><H><Q><V><S><S><I><N><G><G><C><G><M><V><V><G><T><A><S><T><M><V><T><A><R><P><E><Q><S><Q><I><L><I><Q><H><P><D><A><P><S><P><A><Q><P><Q><V><S><P><A><Q><P><T><P><S><T><G><G><R><R><R><R><T><V><D><E><D><P><D><E><R><R><Q><R><F><L><E><R><N><R><A><A><A><S><R><C><R><Q><K><R><K><L><W><V><S><S><L><E><K><K><A><E><E><L><T><S><Q><N><I><Q><L><S><N><E><V><T><L><L><R><N><E><V><A><Q><L><K><Q><L><L><L><A><H><K><D><C><P><V><T><A><L><Q><K><K><T><Q><G><Y><L><E><S><P><K><E><S><S><E><P><T><G><S><P><A><P><V><I><Q><H><S><S><A><T><A><P><S><N><G><L><S><V><R><S><A><A><E><A><V><A><T><S><V><L><T><Q><M><A><S><Q><R><T><E><L><S><M><P><I><Q><S><H><V><I><M><T><P><Q><S><Q><S><A><G><R> | Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.<BOP> | P17544 |
O75396 | SC22B_HUMAN | SEC22 vesicle-trafficking protein-like 1 | Homo | <M><V><L><L><T><M><I><A><R><V><A><D><G><L><P><L><A><A><S><M><Q><E><D><E><Q><S><G><R><D><L><Q><Q><Y><Q><S><Q><A><K><Q><L><F><R><K><L><N><E><Q><S><P><T><R><C><T><L><E><A><G><A><M><T><F><H><Y><I><I><E><Q><G><V><C><Y><L><V><L><C><E><A><A><F><P><K><K><L><A><F><A><Y><L><E><D><L><H><S><E><F><D><E><Q><H><G><K><K><V><P><T><V><S><R><P><Y><S><F><I><E><F><D><T><F><I><Q><K><T><K><K><L><Y><I><D><S><R><A><R><R><N><L><G><S><I><N><T><E><L><Q><D><V><Q><R><I><M><V><A><N><I><E><E><V><L><Q><R><G><E><A><L><S><A><L><D><S><K><A><N><N><L><S><S><L><S><K><K><Y><R><Q><D><A><K><Y><L><N><M><R><S><T><Y><A><K><L><A><A><V><A><V><F><F><I><M><L><I><V><Y><V><R><F><W><W><L> | SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.<BOP> | O75396 |
P14618 | KPYM_HUMAN | p58 | Homo | <M><S><K><P><H><S><E><A><G><T><A><F><I><Q><T><Q><Q><L><H><A><A><M><A><D><T><F><L><E><H><M><C><R><L><D><I><D><S><P><P><I><T><A><R><N><T><G><I><I><C><T><I><G><P><A><S><R><S><V><E><T><L><K><E><M><I><K><S><G><M><N><V><A><R><L><N><F><S><H><G><T><H><E><Y><H><A><E><T><I><K><N><V><R><T><A><T><E><S><F><A><S><D><P><I><L><Y><R><P><V><A><V><A><L><D><T><K><G><P><E><I><R><T><G><L><I><K><G><S><G><T><A><E><V><E><L><K><K><G><A><T><L><K><I><T><L><D><N><A><Y><M><E><K><C><D><E><N><I><L><W><L><D><Y><K><N><I><C><K><V><V><E><V><G><S><K><I><Y><V><D><D><G><L><I><S><L><Q><V><K><Q><K><G><A><D><F><L><V><T><E><V><E><N><G><G><S><L><G><S><K><K><G><V><N><L><P><G><A><A><V><D><L><P><A><V><S><E><K><D><I><Q><D><L><K><F><G><V><E><Q><D><V><D><M><V><F><A><S><F><I><R><K><A><S><D><V><H><E><V><R><K><V><L><G><E><K><G><K><N><I><K><I><I><S><K><I><E><N><H><E><G><V><R><R><F><D><E><I><L><E><A><S><D><G><I><M><V><A><R><G><D><L><G><I><E><I><P><A><E><K><V><F><L><A><Q><K><M><M><I><G><R><C><N><R><A><G><K><P><V><I><C><A><T><Q><M><L><E><S><M><I><K><K><P><R><P><T><R><A><E><G><S><D><V><A><N><A><V><L><D><G><A><D><C><I><M><L><S><G><E><T><A><K><G><D><Y><P><L><E><A><V><R><M><Q><H><L><I><A><R><E><A><E><A><A><I><Y><H><L><Q><L><F><E><E><L><R><R><L><A><P><I><T><S><D><P><T><E><A><T><A><V><G><A><V><E><A><S><F><K><C><C><S><G><A><I><I><V><L><T><K><S><G><R><S><A><H><Q><V><A><R><Y><R><P><R><A><P><I><I><A><V><T><R><N><P><Q><T><A><R><Q><A><H><L><Y><R><G><I><F><P><V><L><C><K><D><P><V><Q><E><A><W><A><E><D><V><D><L><R><V><N><F><A><M><N><V><G><K><A><R><G><F><F><K><K><G><D><V><V><I><V><L><T><G><W><R><P><G><S><G><F><T><N><T><M><R><V><V><P><V><P> | Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth . In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity .<BOP> | P14618 |
O43246 | CTR4_HUMAN | Solute carrier family 7 member 4 | Homo | <M><A><R><G><L><P><T><I><A><S><L><A><R><L><C><Q><K><L><N><R><L><K><P><L><E><D><S><T><M><E><T><S><L><R><R><C><L><S><T><L><D><L><T><L><L><G><V><G><G><M><V><G><S><G><L><Y><V><L><T><G><A><V><A><K><E><V><A><G><P><A><V><L><L><S><F><G><V><A><A><V><A><S><L><L><A><A><L><C><Y><A><E><F><G><A><R><V><P><R><T><G><S><A><Y><L><F><T><Y><V><S><M><G><E><L><W><A><F><L><I><G><W><N><V><L><L><E><Y><I><I><G><G><A><A><V><A><R><A><W><S><G><Y><L><D><S><M><F><S><H><S><I><R><N><F><T><E><T><H><V><G><S><W><Q><V><P><L><L><G><H><Y><P><D><F><L><A><A><G><I><I><L><L><A><S><A><F><V><S><C><G><A><R><V><S><S><W><L><N><H><T><F><S><A><I><S><L><L><V><I><L><F><I><V><I><L><G><F><I><L><A><Q><P><H><N><W><S><A><D><E><G><G><F><A><P><F><G><F><S><G><V><M><A><G><T><A><S><C><F><Y><A><F><V><G><F><D><V><I><A><A><S><S><E><E><A><Q><N><P><R><R><S><V><P><L><A><I><A><I><S><L><A><I><A><A><G><A><Y><I><L><V><S><T><V><L><T><L><M><V><P><W><H><S><L><D><P><D><S><A><L><A><D><A><F><Y><Q><R><G><Y><R><W><A><G><F><I><V><A><A><G><S><I><C><A><M><N><T><V><L><L><S><L><L><F><S><L><P><R><I><V><Y><A><M><A><A><D><G><L><F><F><Q><V><F><A><H><V><H><P><R><T><Q><V><P><V><A><G><T><L><A><F><G><L><L><T><A><F><L><A><L><L><L><D><L><E><S><L><V><Q><F><L><S><L><G><T><L><L><A><Y><T><F><V><A><T><S><I><I><V><L><R><F><Q><K><S><S><P><P><S><S><P><G><P><A><S><P><G><P><L><T><K><Q><Q><S><S><F><S><D><H><L><Q><L><V><G><T><V><H><A><S><V><P><E><P><G><E><L><K><P><A><L><R><P><Y><L><G><F><L><D><G><Y><S><P><G><A><V><V><T><W><A><L><G><V><M><L><A><S><A><I><T><I><G><C><V><L><V><F><G><N><S><T><L><H><L><P><H><W><G><Y><I><L><L><L><L><L><T><S><V><M><F><L><L><S><L><L><V><L><G><A><H><Q><Q><Q><Y><R><E><D><L><F><Q><I><P><M><V><P><L><I><P><A><L><S><I><V><L><N><I><C><L><M><L><K><L><S><Y><L><T><W><V><R><F><S><I><W><L><L><M><G><L><A><V><Y><F><G><Y><G><I><R><H><S><K><E><N><Q><R><E><L><P><G><L><N><S><T><H><Y><V><V><F><P><R><G><S><L><E><E><T><V><Q><A><M><Q><P><P><S><Q><A><P><A><Q><D><P><G><H><M><E> | Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).<BOP> | O43246 |
Q9Y664 | KPTN_HUMAN | Actin-associated protein 2E4 | Homo | <M><M><G><E><A><A><V><A><A><G><P><C><P><L><R><E><D><S><F><T><R><F><S><S><Q><S><N><V><Y><G><L><A><G><G><A><G><G><R><G><E><L><L><A><A><T><L><K><G><K><V><L><G><F><R><Y><Q><D><L><R><Q><K><I><R><P><V><A><K><E><L><Q><F><N><Y><I><P><V><D><A><E><I><V><S><I><D><T><F><N><K><S><P><P><K><R><G><L><V><V><G><I><T><F><I><K><D><S><G><D><K><G><S><P><F><L><N><I><Y><C><D><Y><E><P><G><S><E><Y><N><L><D><S><I><A><Q><S><C><L><N><L><E><L><Q><F><T><P><F><Q><L><C><H><A><E><V><Q><V><G><D><Q><L><E><T><V><F><L><L><S><G><N><D><P><A><I><H><L><Y><K><E><N><E><G><L><H><Q><F><E><E><Q><P><V><E><N><L><F><P><E><L><T><N><L><T><S><S><V><L><W><L><D><V><H><N><F><P><G><T><S><R><R><L><S><A><L><G><C><Q><S><G><Y><V><R><V><A><H><V><D><Q><R><S><R><E><V><L><Q><M><W><S><V><L><Q><D><G><P><I><S><R><V><I><V><F><S><L><S><A><A><K><E><T><K><D><R><P><L><Q><D><E><Y><S><V><L><V><A><S><M><L><E><P><A><V><V><Y><R><D><L><L><N><R><G><L><E><D><Q><L><L><L><P><G><S><D><Q><F><D><S><V><L><C><S><L><V><T><D><V><D><L><D><G><R><P><E><V><L><V><A><T><Y><G><Q><E><L><L><C><Y><K><Y><R><G><P><E><S><G><L><P><E><A><Q><H><G><F><H><L><L><W><Q><R><S><F><S><S><P><L><L><A><M><A><H><V><D><L><T><G><D><G><L><Q><E><L><A><V><V><S><L><K><G><V><H><I><L><Q><H><S><L><I><Q><A><S><E><L><V><L><T><R><L><R><H><Q><V><E><Q><R><R><R><R><L><Q><G><L><E><D><G><A><G><A><G><P><A><E><N><A><A><S> | As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.<BOP> | Q9Y664 |
P56748 | CLD8_HUMAN | Claudin-8 | Homo | <M><A><T><H><A><L><E><I><A><G><L><F><L><G><G><V><G><M><V><G><T><V><A><V><T><V><M><P><Q><W><R><V><S><A><F><I><E><N><N><I><V><V><F><E><N><F><W><E><G><L><W><M><N><C><V><R><Q><A><N><I><R><M><Q><C><K><I><Y><D><S><L><L><A><L><S><P><D><L><Q><A><A><R><G><L><M><C><A><A><S><V><M><S><F><L><A><F><M><M><A><I><L><G><M><K><C><T><R><C><T><G><D><N><E><K><V><K><A><H><I><L><L><T><A><G><I><I><F><I><I><T><G><M><V><V><L><I><P><V><S><W><V><A><N><A><I><I><R><D><F><Y><N><S><I><V><N><V><A><Q><K><R><E><L><G><E><A><L><Y><L><G><W><T><T><A><L><V><L><I><V><G><G><A><L><F><C><C><V><F><C><C><N><E><K><S><S><S><Y><R><Y><S><I><P><S><H><R><T><T><Q><K><S><Y><H><T><G><K><K><S><P><S><V><Y><S><R><S><Q><Y><V> | Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP> | P56748 |
P61020 | RAB5B_HUMAN | Ras-related protein Rab-5B | Homo | <M><T><S><R><S><T><A><R><P><N><G><Q><P><Q><A><S><K><I><C><Q><F><K><L><V><L><L><G><E><S><A><V><G><K><S><S><L><V><L><R><F><V><K><G><Q><F><H><E><Y><Q><E><S><T><I><G><A><A><F><L><T><Q><S><V><C><L><D><D><T><T><V><K><F><E><I><W><D><T><A><G><Q><E><R><Y><H><S><L><A><P><M><Y><Y><R><G><A><Q><A><A><I><V><V><Y><D><I><T><N><Q><E><T><F><A><R><A><K><T><W><V><K><E><L><Q><R><Q><A><S><P><S><I><V><I><A><L><A><G><N><K><A><D><L><A><N><K><R><M><V><E><Y><E><E><A><Q><A><Y><A><D><D><N><S><L><L><F><M><E><T><S><A><K><T><A><M><N><V><N><D><L><F><L><A><I><A><K><K><L><P><K><S><E><P><Q><N><L><G><G><A><A><G><R><S><R><G><V><D><L><H><E><Q><S><Q><Q><N><K><S><Q><C><C><S><N> | Protein transport. Probably involved in vesicular traffic.<BOP> | P61020 |
Q6YI46 | TMM64_HUMAN | Transmembrane protein 64 | Homo | <M><R><S><P><G><G><I><L><L><Q><A><L><P><R><L><L><Q><H><A><A><L><P><G><L><A><E><L><P><A><R><W><A><L><P><R><G><A><G><G><D><G><P><A><D><R><L><P><R><G><G><G><A><S><A><A><A><A><A><A><A><A><S><G><A><L><L><G><A><Y><L><E><R><H><G><P><P><E><A><S><E><L><P><E><P><G><G><A><L><A><G><G><P><G><S><G><G><G><G><V><V><V><G><V><A><E><V><R><N><W><R><C><C><C><L><G><S><T><C><W><C><R><S><L><V><L><V><C><V><L><A><A><L><C><F><A><S><L><A><L><V><R><R><Y><L><H><H><L><L><L><W><V><E><S><L><D><S><L><L><G><V><L><L><F><V><V><G><F><I><V><V><S><F><P><C><G><W><G><Y><I><V><L><N><V><A><A><G><Y><L><Y><G><F><V><L><G><M><G><L><M><M><V><G><V><L><I><G><T><F><I><A><H><V><V><C><K><R><L><L><T><A><W><V><A><A><R><I><Q><S><S><E><K><L><S><A><V><I><R><V><V><E><G><G><S><G><L><K><V><V><A><L><A><R><L><T><P><I><P><F><G><L><Q><N><A><V><F><S><I><T><D><L><S><L><P><N><Y><L><M><A><S><S><V><G><L><L><P><T><Q><L><L><N><S><Y><L><G><T><T><L><R><T><M><E><D><V><I><A><E><Q><S><V><S><G><Y><F><V><F><C><L><Q><I><I><I><S><I><G><L><M><F><Y><V><V><H><R><A><Q><V><E><L><N><A><A><I><V><A><C><E><M><E><L><K><S><S><L><V><K><G><N><Q><P><N><T><S><G><S><S><F><Y><N><K><R><T><L><T><F><S><G><G><G><I><N><V><V> | Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.<BOP> | Q6YI46 |
Q9Y6R9 | CCD61_HUMAN | VFL3 homolog | Homo | <M><D><Q><P><A><G><L><Q><V><D><Y><V><F><R><G><V><E><H><A><V><R><V><M><V><S><G><Q><V><L><E><L><E><V><E><D><R><M><T><A><D><Q><W><R><G><E><F><D><A><G><F><I><E><D><L><T><H><K><T><G><N><F><K><Q><F><N><I><F><C><H><M><L><E><S><A><L><T><Q><S><S><E><S><V><T><L><D><L><L><T><Y><T><D><L><E><S><L><R><N><R><K><M><G><G><R><P><G><S><L><A><P><R><S><A><Q><L><N><S><K><R><Y><L><I><L><I><Y><S><V><E><F><D><R><I><H><Y><P><L><P><L><P><Y><Q><G><K><P><D><P><V><V><L><Q><G><I><I><R><S><L><K><E><E><L><G><R><L><Q><G><L><D><G><Q><N><T><R><D><T><R><E><N><E><I><W><H><L><R><E><Q><V><S><R><L><A><S><E><K><R><E><L><E><A><Q><L><G><R><S><R><E><E><A><L><A><G><R><A><A><R><Q><E><A><E><A><L><R><G><L><V><R><G><L><E><L><E><L><R><Q><E><R><G><L><G><H><R><V><A><G><R><R><G><Q><D><C><R><R><L><A><K><E><L><E><E><A><K><A><S><E><R><S><L><R><A><R><L><K><T><L><T><S><E><L><A><L><Y><K><R><G><R><R><T><P><P><V><Q><P><P><P><T><R><E><D><R><A><S><S><S><R><E><R><S><A><S><R><G><R><G><A><A><R><S><S><S><R><E><S><G><R><G><S><R><G><R><G><R><P><A><R><P><S><P><S><P><T><G><G><R><A><L><R><F><D><P><T><A><F><V><K><A><K><E><R><K><Q><R><E><I><Q><M><K><Q><Q><Q><R><N><R><L><G><S><G><G><S><G><D><G><P><S><V><S><W><S><R><Q><T><Q><P><P><A><A><L><T><G><R><G><D><A><P><N><R><S><R><N><R><S><S><S><V><D><S><F><R><S><R><C><S><S><A><S><S><C><S><D><L><E><D><F><S><E><S><L><S><R><G><G><H><R><R><R><G><K><P><P><S><P><T><P><W><S><G><S><N><M><K><S><P><P><V><E><R><S><H><H><Q><K><S><L><A><N><S><G><G><W><V><P><I><K><E><Y><S><S><E><H><Q><A><A><D><M><A><E><I><D><A><R><L><K><A><L><Q><E><Y><M><N><R><L><D><M><R><S> | Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker . In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning . During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure . Has been proposed to play a role in CEP170 recruitment to centrosomes . However, this function could not be confirmed . Plays a non-essential role in ciliogenesis .<BOP> | Q9Y6R9 |
P29218 | IMPA1_HUMAN | Lithium-sensitive myo-inositol monophosphatase A1 | Homo | <M><A><D><P><W><Q><E><C><M><D><Y><A><V><T><L><A><R><Q><A><G><E><V><V><C><E><A><I><K><N><E><M><N><V><M><L><K><S><S><P><V><D><L><V><T><A><T><D><Q><K><V><E><K><M><L><I><S><S><I><K><E><K><Y><P><S><H><S><F><I><G><E><E><S><V><A><A><G><E><K><S><I><L><T><D><N><P><T><W><I><I><D><P><I><D><G><T><T><N><F><V><H><R><F><P><F><V><A><V><S><I><G><F><A><V><N><K><K><I><E><F><G><V><V><Y><S><C><V><E><G><K><M><Y><T><A><R><K><G><K><G><A><F><C><N><G><Q><K><L><Q><V><S><Q><Q><E><D><I><T><K><S><L><L><V><T><E><L><G><S><S><R><T><P><E><T><V><R><M><V><L><S><N><M><E><K><L><F><C><I><P><V><H><G><I><R><S><V><G><T><A><A><V><N><M><C><L><V><A><T><G><G><A><D><A><Y><Y><E><M><G><I><H><C><W><D><V><A><G><A><G><I><I><V><T><E><A><G><G><V><L><M><D><V><T><G><G><P><F><D><L><M><S><R><R><V><I><A><A><N><N><R><I><L><A><E><R><I><A><K><E><I><Q><V><I><P><L><Q><R><D><D><E><D> | Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<BOP> | P29218 |
P00995 | ISK1_HUMAN | Tumor-associated trypsin inhibitor | Homo | <M><K><V><T><G><I><F><L><L><S><A><L><A><L><L><S><L><S><G><N><T><G><A><D><S><L><G><R><E><A><K><C><Y><N><E><L><N><G><C><T><K><I><Y><D><P><V><C><G><T><D><G><N><T><Y><P><N><E><C><V><L><C><F><E><N><R><K><R><Q><T><S><I><L><I><Q><K><S><G><P><C> | In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.<BOP> | P00995 |
Q92935 | EXTL1_HUMAN | Multiple exostosis-like protein | Homo | <M><Q><S><W><R><R><R><K><S><L><W><L><A><L><S><A><S><W><L><L><L><V><L><L><G><G><F><S><L><L><R><L><A><L><P><P><R><P><R><P><G><A><S><Q><G><W><P><R><W><L><D><A><E><L><L><Q><S><F><S><Q><P><G><E><L><P><E><D><A><V><S><P><P><Q><A><P><H><G><G><S><C><N><W><E><S><C><F><D><T><S><K><C><R><G><D><G><L><K><V><F><V><Y><P><A><V><G><T><I><S><E><T><H><R><R><I><L><A><S><I><E><G><S><R><F><Y><T><F><S><P><A><G><A><C><L><L><L><L><L><S><L><D><A><Q><T><G><E><C><S><S><M><P><L><Q><W><N><R><G><R><N><H><L><V><L><R><L><H><P><A><P><C><P><R><T><F><Q><L><G><Q><A><M><V><A><E><A><S><P><T><V><D><S><F><R><P><G><F><D><V><A><L><P><F><L><P><E><A><H><P><L><R><G><G><A><P><G><Q><L><R><Q><H><S><P><Q><P><G><V><A><L><L><A><L><E><E><E><R><G><G><W><R><T><A><D><T><G><S><S><A><C><P><W><D><G><R><C><E><Q><D><P><G><P><G><Q><T><Q><R><Q><E><T><L><P><N><A><T><F><C><L><I><S><G><H><R><P><E><A><A><S><R><F><L><Q><A><L><Q><A><G><C><I><P><V><L><L><S><P><R><W><E><L><P><F><S><E><V><I><D><W><T><K><A><A><I><V><A><D><E><R><L><P><L><Q><V><L><A><A><L><Q><E><M><S><P><A><R><V><L><A><L><R><Q><Q><T><Q><F><L><W><D><A><Y><F><S><S><V><E><K><V><I><H><T><T><L><E><V><I><Q><D><R><I><F><G><T><S><A><H><P><S><L><L><W><N><S><P><P><G><A><L><L><A><L><S><T><F><S><T><S><P><Q><D><F><P><F><Y><Y><L><Q><Q><G><S><R><P><E><G><R><F><S><A><L><I><W><V><G><P><P><G><Q><P><P><L><K><L><I><Q><A><V><A><G><S><Q><H><C><A><Q><I><L><V><L><W><S><N><E><R><P><L><P><S><R><W><P><E><T><A><V><P><L><T><V><I><D><G><H><R><K><V><S><D><R><F><Y><P><Y><S><T><I><R><T><D><A><I><L><S><L><D><A><R><S><S><L><S><T><S><E><V><D><F><A><F><L><V><W><Q><S><F><P><E><R><M><V><G><F><L><T><S><S><H><F><W><D><E><A><H><G><G><W><G><Y><T><A><E><R><T><N><E><F><S><M><V><L><T><T><A><A><F><Y><H><R><Y><Y><H><T><L><F><T><H><S><L><P><K><A><L><R><T><L><A><D><E><A><P><T><C><V><D><V><L><M><N><F><I><V><A><A><V><T><K><L><P><P><I><K><V><P><Y><G><K><Q><R><Q><E><A><A><P><L><A><P><G><G><P><G><P><R><P><K><P><P><A><P><A><P><D><C><I><N><Q><I><A><A><A><F><G><H><M><P><L><L><S><S><R><L><R><L><D><P><V><L><F><K><D><P><V><S><V><Q><R><K><K><Y><R><S><L><E><K><P> | Probable glycosyltransferase.<BOP> | Q92935 |
P48645 | NMU_HUMAN | Neuromedin-U-25 | Homo | <M><L><R><T><E><S><C><R><P><R><S><P><A><G><Q><V><A><A><A><S><P><L><L><L><L><L><L><L><L><A><W><C><A><G><A><C><R><G><A><P><I><L><P><Q><G><L><Q><P><E><Q><Q><L><Q><L><W><N><E><I><D><D><T><C><S><S><F><L><S><I><D><S><Q><P><Q><A><S><N><A><L><E><E><L><C><F><M><I><M><G><M><L><P><K><P><Q><E><Q><D><E><K><D><N><T><K><R><F><L><F><H><Y><S><K><T><Q><K><L><G><K><S><N><V><V><S><S><V><V><H><P><L><L><Q><L><V><P><H><L><H><E><R><R><M><K><R><F><R><V><D><E><E><F><Q><S><P><F><A><S><Q><S><R><G><Y><F><L><F><R><P><R><N><G><R><R><S><A><G><F><I> | Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.<BOP> | P48645 |
Q6P9F5 | TRI40_HUMAN | RING finger protein 35 | Homo | <M><I><P><L><Q><K><D><N><Q><E><E><G><V><C><P><I><C><Q><E><S><L><K><E><A><V><S><T><N><C><G><H><L><F><C><R><V><C><L><T><Q><H><V><E><K><A><S><A><S><G><V><F><C><C><P><L><C><R><K><P><C><S><E><E><V><L><G><T><G><Y><I><C><P><N><H><Q><K><R><V><C><R><F><C><E><E><S><R><L><L><L><C><V><E><C><L><V><S><P><E><H><M><S><H><H><E><L><T><I><E><N><A><L><S><H><Y><K><E><R><L><N><R><R><S><R><K><L><R><K><D><I><A><E><L><Q><R><L><K><A><Q><Q><E><K><K><L><Q><A><L><Q><F><Q><V><D><H><G><N><H><R><L><E><A><G><P><E><S><Q><H><Q><T><R><E><Q><L><G><A><L><P><Q><Q><W><L><G><Q><L><E><H><M><P><A><E><A><A><R><I><L><D><I><S><R><A><V><T><Q><L><R><S><L><V><I><D><L><E><R><T><A><K><E><L><D><T><N><T><L><K><N><A><G><D><L><L><N><R><S><A><P><Q><K><L><E><V><I><Y><P><Q><L><E><K><G><V><S><E><L><L><L><Q><P><P><Q><K><L> | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response . Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation . Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation .<BOP> | Q6P9F5 |
P30872 | SSR1_HUMAN | SRIF-2 | Homo | <M><F><P><N><G><T><A><S><S><P><S><S><S><P><S><P><S><P><G><S><C><G><E><G><G><G><S><R><G><P><G><A><G><A><A><D><G><M><E><E><P><G><R><N><A><S><Q><N><G><T><L><S><E><G><Q><G><S><A><I><L><I><S><F><I><Y><S><V><V><C><L><V><G><L><C><G><N><S><M><V><I><Y><V><I><L><R><Y><A><K><M><K><T><A><T><N><I><Y><I><L><N><L><A><I><A><D><E><L><L><M><L><S><V><P><F><L><V><T><S><T><L><L><R><H><W><P><F><G><A><L><L><C><R><L><V><L><S><V><D><A><V><N><M><F><T><S><I><Y><C><L><T><V><L><S><V><D><R><Y><V><A><V><V><H><P><I><K><A><A><R><Y><R><R><P><T><V><A><K><V><V><N><L><G><V><W><V><L><S><L><L><V><I><L><P><I><V><V><F><S><R><T><A><A><N><S><D><G><T><V><A><C><N><M><L><M><P><E><P><A><Q><R><W><L><V><G><F><V><L><Y><T><F><L><M><G><F><L><L><P><V><G><A><I><C><L><C><Y><V><L><I><I><A><K><M><R><M><V><A><L><K><A><G><W><Q><Q><R><K><R><S><E><R><K><I><T><L><M><V><M><M><V><V><M><V><F><V><I><C><W><M><P><F><Y><V><V><Q><L><V><N><V><F><A><E><Q><D><D><A><T><V><S><Q><L><S><V><I><L><G><Y><A><N><S><C><A><N><P><I><L><Y><G><F><L><S><D><N><F><K><R><S><F><Q><R><I><L><C><L><S><W><M><D><N><A><A><E><E><P><V><D><Y><Y><A><T><A><L><K><S><R><A><Y><S><V><E><D><F><Q><P><E><N><L><E><S><G><G><V><F><R><N><G><T><C><T><S><R><I><T><T><L> | Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.<BOP> | P30872 |
Q8NGJ5 | O51L1_HUMAN | Olfactory receptor OR11-31 | Homo | <M><G><D><W><N><N><S><D><A><V><E><P><I><F><I><L><R><G><F><P><G><L><E><Y><V><H><S><W><L><S><I><L><F><C><L><A><Y><L><V><A><F><M><G><N><V><T><I><L><S><V><I><W><I><E><S><S><L><H><Q><P><M><Y><Y><F><I><S><I><L><A><V><N><D><L><G><M><S><L><S><T><L><P><T><M><L><A><V><L><W><L><D><A><P><E><I><Q><A><S><A><C><Y><A><Q><L><F><F><I><H><T><F><T><F><L><E><S><S><V><L><L><A><M><A><F><D><R><F><V><A><I><C><H><P><L><H><Y><P><T><I><L><T><N><S><V><I><G><K><I><G><L><A><C><L><L><R><S><L><G><V><V><L><P><T><P><L><L><L><R><H><Y><H><Y><C><H><G><N><A><L><S><H><A><F><C><L><H><Q><D><V><L><R><L><S><C><T><D><A><R><T><N><S><I><Y><G><L><C><V><V><I><A><T><L><G><V><D><S><I><F><I><L><L><S><Y><V><L><I><L><N><T><V><L><D><I><A><S><R><E><E><Q><L><K><A><L><N><T><C><V><S><H><I><C><V><V><L><I><F><F><V><P><V><I><G><V><S><M><V><H><R><F><G><K><H><L><S><P><I><V><H><I><L><M><A><D><I><Y><L><L><L><P><P><V><L><N><P><I><V><Y><S><V><R><T><K><Q><I><R><L><G><I><L><H><K><F><V><L><R><R><R><F> | Odorant receptor.<BOP> | Q8NGJ5 |
Q96BR1 | SGK3_HUMAN | Serum/glucocorticoid-regulated kinase-like | Homo | <M><Q><R><D><H><T><M><D><Y><K><E><S><C><P><S><V><S><I><P><S><S><D><E><H><R><E><K><K><K><R><F><T><V><Y><K><V><L><V><S><V><G><R><S><E><W><F><V><F><R><R><Y><A><E><F><D><K><L><Y><N><T><L><K><K><Q><F><P><A><M><A><L><K><I><P><A><K><R><I><F><G><D><N><F><D><P><D><F><I><K><Q><R><R><A><G><L><N><E><F><I><Q><N><L><V><R><Y><P><E><L><Y><N><H><P><D><V><R><A><F><L><Q><M><D><S><P><K><H><Q><S><D><P><S><E><D><E><D><E><R><S><S><Q><K><L><H><S><T><S><Q><N><I><N><L><G><P><S><G><N><P><H><A><K><P><T><D><F><D><F><L><K><V><I><G><K><G><S><F><G><K><V><L><L><A><K><R><K><L><D><G><K><F><Y><A><V><K><V><L><Q><K><K><I><V><L><N><R><K><E><Q><K><H><I><M><A><E><R><N><V><L><L><K><N><V><K><H><P><F><L><V><G><L><H><Y><S><F><Q><T><T><E><K><L><Y><F><V><L><D><F><V><N><G><G><E><L><F><F><H><L><Q><R><E><R><S><F><P><E><H><R><A><R><F><Y><A><A><E><I><A><S><A><L><G><Y><L><H><S><I><K><I><V><Y><R><D><L><K><P><E><N><I><L><L><D><S><V><G><H><V><V><L><T><D><F><G><L><C><K><E><G><I><A><I><S><D><T><T><T><T><F><C><G><T><P><E><Y><L><A><P><E><V><I><R><K><Q><P><Y><D><N><T><V><D><W><W><C><L><G><A><V><L><Y><E><M><L><Y><G><L><P><P><F><Y><C><R><D><V><A><E><M><Y><D><N><I><L><H><K><P><L><S><L><R><P><G><V><S><L><T><A><W><S><I><L><E><E><L><L><E><K><D><R><Q><N><R><L><G><A><K><E><D><F><L><E><I><Q><N><H><P><F><F><E><S><L><S><W><A><D><L><V><Q><K><K><I><P><P><P><F><N><P><N><V><A><G><P><D><D><I><R><N><F><D><T><A><F><T><E><E><T><V><P><Y><S><V><C><V><S><S><D><Y><S><I><V><N><A><S><V><L><E><A><D><D><A><F><V><G><F><S><Y><A><P><P><S><E><D><L><F><L> | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the | Q96BR1 |
Q96RD3 | O52E6_HUMAN | Olfactory receptor OR11-58 | Homo | <M><P><I><A><N><D><T><Q><F><H><T><S><S><F><L><L><L><G><I><P><G><L><E><D><V><H><I><W><I><G><F><P><F><F><S><V><Y><L><I><A><L><L><G><N><A><A><I><F><F><V><I><Q><T><E><Q><S><L><H><E><P><M><Y><Y><C><L><A><M><L><D><S><I><D><L><S><L><S><T><A><T><I><P><K><M><L><G><I><F><W><F><N><I><K><E><I><S><F><G><G><Y><L><S><Q><M><F><F><I><H><F><F><T><V><M><E><S><I><V><L><V><A><M><A><F><D><R><Y><I><A><I><C><K><P><L><W><Y><T><M><I><L><T><S><K><I><I><S><L><I><A><G><I><A><V><L><R><S><L><Y><M><V><I><P><L><V><F><L><L><L><R><L><P><F><C><G><H><R><I><I><P><H><T><Y><C><E><H><M><G><I><A><R><L><A><C><A><S><I><K><V><N><I><M><F><G><L><G><S><I><S><L><L><L><L><D><V><L><L><I><I><L><S><H><I><R><I><L><Y><A><V><F><C><L><P><S><W><E><A><R><L><K><A><L><N><T><C><G><S><H><I><G><V><I><L><A><F><S><T><P><A><F><F><S><F><F><T><H><C><F><G><H><D><I><P><Q><Y><I><H><I><F><L><A><N><L><Y><V><V><V><P><P><T><L><N><P><V><I><Y><G><V><R><T><K><H><I><R><E><T><V><L><R><I><F><F><K><T><D><H> | Odorant receptor.<BOP> | Q96RD3 |
Q9BYR4 | KRA43_HUMAN | Ultrahigh sulfur keratin-associated protein 4.3 | Homo | <M><V><S><S><C><C><G><S><V><C><S><D><Q><S><C><G><Q><G><L><G><Q><E><S><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><I><S><S><C><C><R><P><S><C><C><I><S><S><C><C><K><P><S><C><C><R><T><T><C><C><R><P><S><C><C><I><S><S><C><C><R><P><S><C><C><I><S><S><C><C><K><P><S><C><C><R><T><T><C><C><R><P><S><C><C><I><S><S><C><C><R><P><S><C><C><I><S><S><C><C><K><P><S><C><C><Q><T><T><C><C><R><P><S><C><C><I><S><S><C><Y><R><P><Q><C><C><Q><P><S><C><C><R><P><A><C><C><I><S><S><C><C><H><P><S><C><C><V><S><S><C><R><C><P><F><S><C><P><T><T><C><C><R><T><T><C><F><H><P><I><C><C><G><S><S><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q9BYR4 |
Q9NPE3 | NOP10_HUMAN | snoRNP protein NOP10 | Homo | <M><F><L><Q><Y><Y><L><N><E><Q><G><D><R><V><Y><T><L><K><K><F><D><P><M><G><Q><Q><T><C><S><A><H><P><A><R><F><S><P><D><D><K><Y><S><R><H><R><I><T><I><K><K><R><F><K><V><L><M><T><Q><Q><P><R><P><V><L> | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.<BOP> | Q9NPE3 |
Q9UIV8 | SPB13_HUMAN | Proteinase inhibitor 13 | Homo | <M><D><S><L><G><A><V><S><T><R><L><G><F><D><L><F><K><E><L><K><K><T><N><D><G><N><I><F><F><S><P><V><G><I><L><T><A><I><G><M><V><L><L><G><T><R><G><A><T><A><S><Q><L><E><E><V><F><H><S><E><K><E><T><K><S><S><R><I><K><A><E><E><K><E><V><I><E><N><T><E><A><V><H><Q><Q><F><Q><K><F><L><T><E><I><S><K><L><T><N><D><Y><E><L><N><I><T><N><R><L><F><G><E><K><T><Y><L><F><L><Q><K><Y><L><D><Y><V><E><K><Y><Y><H><A><S><L><E><P><V><D><F><V><N><A><A><D><E><S><R><K><K><I><N><S><W><V><E><S><K><T><N><E><K><I><K><D><L><F><P><D><G><S><I><S><S><S><T><K><L><V><L><V><N><M><V><Y><F><K><G><Q><W><D><R><E><F><K><K><E><N><T><K><E><E><K><F><W><M><N><K><S><T><S><K><S><V><Q><M><M><T><Q><S><H><S><F><S><F><T><F><L><E><D><L><Q><A><K><I><L><G><I><P><Y><K><N><N><D><L><S><M><F><V><L><L><P><N><D><I><D><G><L><E><K><I><I><D><K><I><S><P><E><K><L><V><E><W><T><S><P><G><H><M><E><E><R><K><V><N><L><H><L><P><R><F><E><V><E><D><G><Y><D><L><E><A><V><L><A><A><M><G><M><G><D><A><F><S><E><H><K><A><D><Y><S><G><M><S><S><G><S><G><L><Y><A><Q><K><F><L><H><S><S><F><V><A><V><T><E><E><G><T><E><A><A><A><A><T><G><I><G><F><T><V><T><S><A><P><G><H><E><N><V><H><C><N><H><P><F><L><F><F><I><R><H><N><E><S><N><S><I><L><F><F><G><R><F><S><S><P> | May play a role in the proliferation or differentiation of keratinocytes.<BOP> | Q9UIV8 |
Q7L8C5 | SYT13_HUMAN | Synaptotagmin XIII | Homo | <M><V><L><S><V><P><V><I><A><L><G><A><T><L><G><T><A><T><S><I><L><A><L><C><G><V><T><C><L><C><R><H><M><H><P><K><K><G><L><L><P><R><D><Q><D><P><D><L><E><K><A><K><P><S><L><L><G><S><A><Q><Q><F><N><V><K><K><S><T><E><P><V><Q><P><R><A><L><L><K><F><P><D><I><Y><G><P><R><P><A><V><T><A><P><E><V><I><N><Y><A><D><Y><S><L><R><S><T><E><E><P><T><A><P><A><S><P><Q><P><P><N><D><S><R><L><K><R><Q><V><T><E><E><L><F><I><L><P><Q><N><G><V><V><E><D><V><C><V><M><E><T><W><N><P><E><K><A><A><S><W><N><Q><A><P><K><L><H><Y><C><L><D><Y><D><C><Q><K><A><E><L><F><V><T><R><L><E><A><V><T><S><N><H><D><G><G><C><D><C><Y><V><Q><G><S><V><A><N><R><T><G><S><V><E><A><Q><T><A><L><K><K><R><Q><L><H><T><T><W><E><E><G><L><V><L><P><L><A><E><E><E><L><P><T><A><T><L><T><L><T><L><R><T><C><D><R><F><S><R><H><S><V><A><G><E><L><R><L><G><L><D><G><T><S><V><P><L><G><A><A><Q><W><G><E><L><K><T><S><A><K><E><P><S><A><G><A><G><E><V><L><L><S><I><S><Y><L><P><A><A><N><R><L><L><V><V><L><I><K><A><K><N><L><H><S><N><Q><S><K><E><L><L><G><K><D><V><S><V><K><V><T><L><K><H><Q><A><R><K><L><K><K><K><Q><T><K><R><A><K><H><K><I><N><P><V><W><N><E><M><I><M><F><E><L><P><D><D><L><L><Q><A><S><S><V><E><L><E><V><L><G><Q><D><D><S><G><Q><S><C><A><L><G><H><C><S><L><G><L><H><T><S><G><S><E><R><S><H><W><E><E><M><L><K><N><P><R><R><Q><I><A><M><W><H><Q><L><H><L> | May be involved in transport vesicle docking to the plasma membrane.<BOP> | Q7L8C5 |
P57772 | SELB_HUMAN | Eukaryotic elongation factor, selenocysteine-tRNA-specific | Homo | <M><A><G><R><R><V><N><V><N><V><G><V><L><G><H><I><D><S><G><K><T><A><L><A><R><A><L><S><T><T><A><S><T><A><A><F><D><K><Q><P><Q><S><R><E><R><G><I><T><L><D><L><G><F><S><C><F><S><V><P><L><P><A><R><L><R><S><S><L><P><E><F><Q><A><A><P><E><A><E><P><E><P><G><E><P><L><L><Q><V><T><L><V><D><C><P><G><H><A><S><L><I><R><T><I><I><G><G><A><Q><I><I><D><L><M><M><L><V><I><D><V><T><K><G><M><Q><T><Q><S><A><E><C><L><V><I><G><Q><I><A><C><Q><K><L><V><V><V><L><N><K><I><D><L><L><P><E><G><K><R><Q><A><A><I><D><K><M><T><K><K><M><Q><K><T><L><E><N><T><K><F><R><G><A><P><I><I><P><V><A><A><K><P><G><G><P><E><A><P><E><T><E><A><P><Q><G><I><P><E><L><I><E><L><L><T><S><Q><I><S><I><P><T><R><D><P><S><G><P><F><L><M><S><V><D><H><C><F><S><I><K><G><Q><G><T><V><M><T><G><T><I><L><S><G><S><I><S><L><G><D><S><V><E><I><P><A><L><K><V><V><K><K><V><K><S><M><Q><M><F><H><M><P><I><T><S><A><M><Q><G><D><R><L><G><I><C><V><T><Q><F><D><P><K><L><L><E><R><G><L><V><C><A><P><E><S><L><H><T><V><H><A><A><L><I><S><V><E><K><I><P><Y><F><R><G><P><L><Q><T><K><A><K><F><H><I><T><V><G><H><E><T><V><M><G><R><L><M><F><F><S><P><A><P><D><N><F><D><Q><E><P><I><L><D><S><F><N><F><S><Q><E><Y><L><F><Q><E><Q><Y><L><S><K><D><L><T><P><A><V><T><D><N><D><E><A><D><K><K><A><G><Q><A><T><E><G><H><C><P><R><Q><Q><W><A><L><V><E><F><E><K><P><V><T><C><P><R><L><C><L><V><I><G><S><R><L><D><A><D><I><H><T><N><T><C><R><L><A><F><H><G><I><L><L><H><G><L><E><D><R><N><Y><A><D><S><F><L><P><R><L><K><V><Y><K><L><K><H><K><H><G><L><V><E><R><A><M><D><D><Y><S><V><I><G><R><S><L><F><K><K><E><T><N><I><Q><L><F><V><G><L><K><V><H><L><S><T><G><E><L><G><I><I><D><S><A><F><G><Q><S><G><K><F><K><I><H><I><P><G><G><L><S><P><E><S><K><K><I><L><T><P><A><L><K><K><R><A><R><A><G><R><G><E><A><T><R><Q><E><E><S><A><E><R><S><E><P><S><Q><H><V><V><L><S><L><T><F><K><R><Y><V><F><D><T><H><K><R><M><V><Q><S><P> | Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.<BOP> | P57772 |
Q9H223 | EHD4_HUMAN | PAST homolog 4 | Homo | <M><F><S><W><M><G><R><Q><A><G><G><R><E><R><A><G><G><A><D><A><V><Q><T><V><T><G><G><L><R><S><L><Y><L><R><K><V><L><P><L><E><E><A><Y><R><F><H><E><F><H><S><P><A><L><E><D><A><D><F><E><N><K><P><M><I><L><L><V><G><Q><Y><S><T><G><K><T><T><F><I><R><Y><L><L><E><Q><D><F><P><G><M><R><I><G><P><E><P><T><T><D><S><F><I><A><V><M><Y><G><E><T><E><G><S><T><P><G><N><A><L><V><V><D><P><K><K><P><F><R><K><L><S><R><F><G><N><A><F><L><N><R><F><M><C><S><Q><L><P><N><Q><V><L><K><S><I><S><V><I><D><S><P><G><I><L><S><G><E><K><Q><R><I><S><R><G><Y><D><F><C><Q><V><L><Q><W><F><A><E><R><V><D><R><I><I><L><L><F><D><A><H><K><L><D><I><S><D><E><F><S><E><A><I><K><A><F><R><G><Q><D><D><K><I><R><V><V><L><N><K><A><D><Q><V><D><T><Q><Q><L><M><R><V><Y><G><A><L><M><W><S><L><G><K><V><I><N><T><P><E><V><L><R><V><Y><I><G><S><F><W><A><Q><P><L><Q><N><T><D><N><R><R><L><F><E><A><E><A><Q><D><L><F><R><D><I><Q><S><L><P><Q><K><A><A><V><R><K><L><N><D><L><I><K><R><A><R><L><A><K><V><H><A><Y><I><I><S><Y><L><K><K><E><M><P><S><V><F><G><K><E><N><K><K><R><E><L><I><S><R><L><P><E><I><Y><I><Q><L><Q><R><E><Y><Q><I><S><A><G><D><F><P><E><V><K><A><M><Q><E><Q><L><E><N><Y><D><F><T><K><F><H><S><L><K><P><K><L><I><E><A><V><D><N><M><L><S><N><K><I><S><P><L><M><N><L><I><S><Q><E><E><T><S><T><P><T><Q><L><V><Q><G><G><A><F><D><G><T><T><E><G><P><F><N><Q><G><Y><G><E><G><A><K><E><G><A><D><E><E><E><W><V><V><A><K><D><K><P><V><Y><D><E><L><F><Y><T><L><S><P><I><N><G><K><I><S><G><V><N><A><K><K><E><M><V><T><S><K><L><P><N><S><V><L><G><K><I><W><K><L><A><D><C><D><C><D><G><M><L><D><E><E><E><F><A><L><A><K><H><L><I><K><I><K><L><D><G><Y><E><L><P><S><S><L><P><P><H><L><V><P><P><S><H><R><K><S><L><P><K><A><D> | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.<BOP> | Q9H223 |
Q6YBV0 | S36A4_HUMAN | Solute carrier family 36 member 4 | Homo | <M><E><A><A><A><T><P><A><A><A><G><A><A><R><R><E><E><L><D><M><D><V><M><R><P><L><I><N><E><Q><N><F><D><G><T><S><D><E><E><H><E><Q><E><L><L><P><V><Q><K><H><Y><Q><L><D><D><Q><E><G><I><S><F><V><Q><T><L><M><H><L><L><K><G><N><I><G><T><G><L><L><G><L><P><L><A><I><K><N><A><G><I><V><L><G><P><I><S><L><V><F><I><G><I><I><S><V><H><C><M><H><I><L><V><R><C><S><H><F><L><C><L><R><F><K><K><S><T><L><G><Y><S><D><T><V><S><F><A><M><E><V><S><P><W><S><C><L><Q><K><Q><A><A><W><G><R><S><V><V><D><F><F><L><V><I><T><Q><L><G><F><C><S><V><Y><I><V><F><L><A><E><N><V><K><Q><V><H><E><G><F><L><E><S><K><V><F><I><S><N><S><T><N><S><S><N><P><C><E><R><R><S><V><D><L><R><I><Y><M><L><C><F><L><P><F><I><I><L><L><V><F><I><R><E><L><K><N><L><F><V><L><S><F><L><A><N><V><S><M><A><V><S><L><V><I><I><Y><Q><Y><V><V><R><N><M><P><D><P><H><N><L><P><I><V><A><G><W><K><K><Y><P><L><F><F><G><T><A><V><F><A><F><E><G><I><G><V><V><L><P><L><E><N><Q><M><K><E><S><K><R><F><P><Q><A><L><N><I><G><M><G><I><V><T><T><L><Y><V><T><L><A><T><L><G><Y><M><C><F><H><D><E><I><K><G><S><I><T><L><N><L><P><Q><D><V><W><L><Y><Q><S><V><K><I><L><Y><S><F><G><I><F><V><T><Y><S><I><Q><F><Y><V><P><A><E><I><I><I><P><G><I><T><S><K><F><H><T><K><W><K><Q><I><C><E><F><G><I><R><S><F><L><V><S><I><T><C><A><G><A><I><L><I><P><R><L><D><I><V><I><S><F><V><G><A><V><S><S><S><T><L><A><L><I><L><P><P><L><V><E><I><L><T><F><S><K><E><H><Y><N><I><W><M><V><L><K><N><I><S><I><A><F><T><G><V><V><G><F><L><L><G><T><Y><I><T><V><E><E><I><I><Y><P><T><P><K><V><V><A><G><T><P><Q><S><P><F><L><N><L><N><S><T><C><L><T><S><G><L><K> | Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.<BOP> | Q6YBV0 |
P27658 | CO8A1_HUMAN | Vastatin | Homo | <M><A><V><L><P><G><P><L><Q><L><L><G><V><L><L><T><I><S><L><S><S><I><R><L><I><Q><A><G><A><Y><Y><G><I><K><P><L><P><P><Q><I><P><P><Q><M><P><P><Q><I><P><Q><Y><Q><P><L><G><Q><Q><V><P><H><M><P><L><A><K><D><G><L><A><M><G><K><E><M><P><H><L><Q><Y><G><K><E><Y><P><H><L><P><Q><Y><M><K><E><I><Q><P><A><P><R><M><G><K><E><A><V><P><K><K><G><K><E><I><P><L><A><S><L><R><G><E><Q><G><P><R><G><E><P><G><P><R><G><P><P><G><P><P><G><L><P><G><H><G><I><P><G><I><K><G><K><P><G><P><Q><G><Y><P><G><V><G><K><P><G><M><P><G><M><P><G><K><P><G><A><M><G><M><P><G><A><K><G><E><I><G><Q><K><G><E><I><G><P><M><G><I><P><G><P><Q><G><P><P><G><P><H><G><L><P><G><I><G><K><P><G><G><P><G><L><P><G><Q><P><G><P><K><G><D><R><G><P><K><G><L><P><G><P><Q><G><L><R><G><P><K><G><D><K><G><F><G><M><P><G><A><P><G><V><K><G><P><P><G><M><H><G><P><P><G><P><V><G><L><P><G><V><G><K><P><G><V><T><G><F><P><G><P><Q><G><P><L><G><K><P><G><A><P><G><E><P><G><P><Q><G><P><I><G><V><P><G><V><Q><G><P><P><G><I><P><G><I><G><K><P><G><Q><D><G><I><P><G><Q><P><G><F><P><G><G><K><G><E><Q><G><L><P><G><L><P><G><P><P><G><L><P><G><I><G><K><P><G><F><P><G><P><K><G><D><R><G><M><G><G><V><P><G><A><L><G><P><R><G><E><K><G><P><I><G><A><P><G><I><G><G><P><P><G><E><P><G><L><P><G><I><P><G><P><M><G><P><P><G><A><I><G><F><P><G><P><K><G><E><G><G><I><V><G><P><Q><G><P><P><G><P><K><G><E><P><G><L><Q><G><F><P><G><K><P><G><F><L><G><E><V><G><P><P><G><M><R><G><L><P><G><P><I><G><P><K><G><E><A><G><Q><K><G><V><P><G><L><P><G><V><P><G><L><L><G><P><K><G><E><P><G><I><P><G><D><Q><G><L><Q><G><P><P><G><I><P><G><I><G><G><P><S><G><P><I><G><P><P><G><I><P><G><P><K><G><E><P><G><L><P><G><P><P><G><F><P><G><I><G><K><P><G><V><A><G><L><H><G><P><P><G><K><P><G><A><L><G><P><Q><G><Q><P><G><L><P><G><P><P><G><P><P><G><P><P><G><P><P><A><V><M><P><P><T><P><P><P><Q><G><E><Y><L><P><D><M><G><L><G><I><D><G><V><K><P><P><H><A><Y><G><A><K><K><G><K><N><G><G><P><A><Y><E><M><P><A><F><T><A><E><L><T><A><P><F><P><P><V><G><A><P><V><K><F><N><K><L><L><Y><N><G><R><Q><N><Y><N><P><Q><T><G><I><F><T><C><E><V><P><G><V><Y><Y><F><A><Y><H><V><H><C><K><G><G><N><V><W><V><A><L><F><K><N><N><E><P><V><M><Y><T><Y><D><E><Y><K><K><G><F><L><D><Q><A><S><G><S><A><V><L><L><L><R><P><G><D><R><V><F><L><Q><M><P><S><E><Q><A><A><G><L><Y><A><G><Q><Y><V><H><S><S><F><S><G><Y><L><L><Y><P><M> | Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.<BOP> | P27658 |
O75251 | NDUS7_HUMAN | PSST subunit | Homo | <M><A><V><L><S><A><P><G><L><R><G><F><R><I><L><G><L><R><S><S><V><G><P><A><V><Q><A><R><G><V><H><Q><S><V><A><T><D><G><P><S><S><T><Q><P><A><L><P><K><A><R><A><V><A><P><K><P><S><S><R><G><E><Y><V><V><A><K><L><D><D><L><V><N><W><A><R><R><S><S><L><W><P><M><T><F><G><L><A><C><C><A><V><E><M><M><H><M><A><A><P><R><Y><D><M><D><R><F><G><V><V><F><R><A><S><P><R><Q><S><D><V><M><I><V><A><G><T><L><T><N><K><M><A><P><A><L><R><K><V><Y><D><Q><M><P><E><P><R><Y><V><V><S><M><G><S><C><A><N><G><G><G><Y><Y><H><Y><S><Y><S><V><V><R><G><C><D><R><I><V><P><V><D><I><Y><I><P><G><C><P><P><T><A><E><A><L><L><Y><G><I><L><Q><L><Q><R><K><I><K><R><E><R><R><L><Q><I><W><Y><R><R> | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity of complex I .<BOP> | O75251 |
P0DMS8 | AA3R_HUMAN | Adenosine receptor A3 | Homo | <M><P><N><N><S><T><A><L><S><L><A><N><V><T><Y><I><T><M><E><I><F><I><G><L><C><A><I><V><G><N><V><L><V><I><C><V><V><K><L><N><P><S><L><Q><T><T><T><F><Y><F><I><V><S><L><A><L><A><D><I><A><V><G><V><L><V><M><P><L><A><I><V><V><S><L><G><I><T><I><H><F><Y><S><C><L><F><M><T><C><L><L><L><I><F><T><H><A><S><I><M><S><L><L><A><I><A><V><D><R><Y><L><R><V><K><L><T><V><R><Y><K><R><V><T><T><H><R><R><I><W><L><A><L><G><L><C><W><L><V><S><F><L><V><G><L><T><P><M><F><G><W><N><M><K><L><T><S><E><Y><H><R><N><V><T><F><L><S><C><Q><F><V><S><V><M><R><M><D><Y><M><V><Y><F><S><F><L><T><W><I><F><I><P><L><V><V><M><C><A><I><Y><L><D><I><F><Y><I><I><R><N><K><L><S><L><N><L><S><N><S><K><E><T><G><A><F><Y><G><R><E><F><K><T><A><K><S><L><F><L><V><L><F><L><F><A><L><S><W><L><P><L><S><I><I><N><C><I><I><Y><F><N><G><E><V><P><Q><L><V><L><Y><M><G><I><L><L><S><H><A><N><S><M><M><N><P><I><V><Y><A><Y><K><I><K><K><F><K><E><T><Y><L><L><I><L><K><A><C><V><V><C><H><P><S><D><S><L><D><T><S><I><E><K><N><S><E> | Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase .<BOP> | P0DMS8 |
Q15545 | TAF7_HUMAN | Transcription initiation factor TFIID 55 kDa subunit | Homo | <M><S><K><S><K><D><D><A><P><H><E><L><E><S><Q><F><I><L><R><L><P><P><E><Y><A><S><T><V><R><R><A><V><Q><S><G><H><V><N><L><K><D><R><L><T><I><E><L><H><P><D><G><R><H><G><I><V><R><V><D><R><V><P><L><A><S><K><L><V><D><L><P><C><V><M><E><S><L><K><T><I><D><K><K><T><F><Y><K><T><A><D><I><C><Q><M><L><V><S><T><V><D><G><D><L><Y><P><P><V><E><E><P><V><A><S><T><D><P><K><A><S><K><K><K><D><K><D><K><E><K><K><F><I><W><N><H><G><I><T><L><P><L><K><N><V><R><K><R><R><F><R><K><T><A><K><K><K><Y><I><E><S><P><D><V><E><K><E><V><K><R><L><L><S><T><D><A><E><A><V><S><T><R><W><E><I><I><A><E><D><E><T><K><E><A><E><N><Q><G><L><D><I><S><S><P><G><M><S><G><H><R><Q><G><H><D><S><L><E><H><D><E><L><R><E><I><F><N><D><L><S><S><S><S><E><D><E><D><E><T><Q><H><Q><D><E><E><D><I><N><I><I><D><T><E><E><D><L><E><R><Q><L><Q><D><K><L><N><E><S><D><E><Q><H><Q><E><N><E><G><T><N><Q><L><V><M><G><I><Q><K><Q><I><D><N><M><K><G><K><L><Q><E><T><Q><D><R><A><K><R><Q><E><D><L><I><M><K><V><E><N><L><A><L><K><N><R><F><Q><A><V><L><D><E><L><K><Q><K><E><D><R><E><K><E><Q><L><S><S><L><Q><E><E><L><E><S><L><L><E><K> | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription . TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) . The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 . TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2 . Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta) .<BOP> | Q15545 |
P00973 | OAS1_HUMAN | p46/p42 OAS | Homo | <M><M><D><L><R><N><T><P><A><K><S><L><D><K><F><I><E><D><Y><L><L><P><D><T><C><F><R><M><Q><I><N><H><A><I><D><I><I><C><G><F><L><K><E><R><C><F><R><G><S><S><Y><P><V><C><V><S><K><V><V><K><G><G><S><S><G><K><G><T><T><L><R><G><R><S><D><A><D><L><V><V><F><L><S><P><L><T><T><F><Q><D><Q><L><N><R><R><G><E><F><I><Q><E><I><R><R><Q><L><E><A><C><Q><R><E><R><A><F><S><V><K><F><E><V><Q><A><P><R><W><G><N><P><R><A><L><S><F><V><L><S><S><L><Q><L><G><E><G><V><E><F><D><V><L><P><A><F><D><A><L><G><Q><L><T><G><G><Y><K><P><N><P><Q><I><Y><V><K><L><I><E><E><C><T><D><L><Q><K><E><G><E><F><S><T><C><F><T><E><L><Q><R><D><F><L><K><Q><R><P><T><K><L><K><S><L><I><R><L><V><K><H><W><Y><Q><N><C><K><K><K><L><G><K><L><P><P><Q><Y><A><L><E><L><L><T><V><Y><A><W><E><R><G><S><M><K><T><H><F><N><T><A><Q><G><F><R><T><V><L><E><L><V><I><N><Y><Q><Q><L><C><I><Y><W><T><K><Y><Y><D><F><K><N><P><I><I><E><K><Y><L><R><R><Q><L><T><K><P><R><P><V><I><L><D><P><A><D><P><T><G><N><L><G><G><G><D><P><K><G><W><R><Q><L><A><Q><E><A><E><A><W><L><N><Y><P><C><F><K><N><W><D><G><S><P><V><S><S><W><I><L><L><A><E><S><N><S><A><D><D><E><T><D><D><P><R><R><Y><Q><K><Y><G><Y><I><G><T><H><E><Y><P><H><F><S><H><R><P><S><T><L><Q><A><A><S><T><P><Q><A><E><E><D><W><T><C><T><I><L> | Not prenylated at C-terminal, is diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.<BOP> | P00973 |
Q99627 | CSN8_HUMAN | JAB1-containing signalosome subunit 8 | Homo | <M><P><V><A><V><M><A><E><S><A><F><S><F><K><K><L><L><D><Q><C><E><N><Q><E><L><E><A><P><G><G><I><A><T><P><P><V><Y><G><Q><L><L><A><L><Y><L><L><H><N><D><M><N><N><A><R><Y><L><W><K><R><I><P><P><A><I><K><S><A><N><S><E><L><G><G><I><W><S><V><G><Q><R><I><W><Q><R><D><F><P><G><I><Y><T><T><I><N><A><H><Q><W><S><E><T><V><Q><P><I><M><E><A><L><R><D><A><T><R><R><R><A><F><A><L><V><S><Q><A><Y><T><S><I><I><A><D><D><F><A><A><F><V><G><L><P><V><E><E><A><V><K><G><I><L><E><Q><G><W><Q><A><D><S><T><T><R><M><V><L><P><R><K><P><V><A><G><A><L><D><V><S><F><N><K><F><I><P><L><S><E><P><A><P><V><P><P><I><P><N><E><Q><Q><L><A><R><L><T><D><Y><V><A><F><L><E><N> | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.<BOP> | Q99627 |
P17041 | ZNF32_HUMAN | Zinc finger protein KOX30 | Homo | <M><F><G><F><P><T><A><T><L><L><D><C><H><G><R><Y><A><Q><N><V><A><F><F><N><V><M><T><E><A><H><H><K><Y><D><H><S><E><A><T><G><S><S><S><W><D><I><Q><N><S><F><R><R><E><K><L><E><Q><K><S><P><D><S><K><T><L><Q><E><D><S><P><G><V><R><Q><R><V><Y><E><C><Q><E><C><G><K><S><F><R><Q><K><G><S><L><T><L><H><E><R><I><H><T><G><Q><K><P><F><E><C><T><H><C><G><K><S><F><R><A><K><G><N><L><V><T><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><S><F><S><Q><R><G><S><L><A><V><H><E><R><L><H><T><G><Q><K><P><Y><E><C><A><I><C><Q><R><S><F><R><N><Q><S><N><L><A><V><H><R><R><V><H><S><G><E><K><P><Y><R><C><D><Q><C><G><K><A><F><S><Q><K><G><S><L><I><V><H><I><R><V><H><T><G><L><K><P><Y><A><C><T><Q><C><R><K><S><F><H><T><R><G><N><C><I><L><H><G><K><I><H><T><G><E><T><P><Y><L><C><G><Q><C><G><K><S><F><T><Q><R><G><S><L><A><V><H><Q><R><S><C><S><Q><R><L><T><L> | May be involved in transcriptional regulation.<BOP> | P17041 |
O00139 | KIF2A_HUMAN | Kinesin-2 | Homo | <M><A><T><A><N><F><G><K><I><Q><I><G><I><Y><V><E><I><K><R><S><D><G><R><I><H><Q><A><M><V><T><S><L><N><E><D><N><E><S><V><T><V><E><W><I><E><N><G><D><T><K><G><K><E><I><D><L><E><S><I><F><S><L><N><P><D><L><V><P><D><E><E><I><E><P><S><P><E><T><P><P><P><P><A><S><S><A><K><V><N><K><I><V><K><N><R><R><T><V><A><S><I><K><N><D><P><P><S><R><D><N><R><V><V><G><S><A><R><A><R><P><S><Q><F><P><E><Q><S><S><S><A><Q><Q><N><G><S><V><S><D><I><S><P><V><Q><A><A><K><K><E><F><G><P><P><S><R><R><K><S><N><C><V><K><E><V><E><K><L><Q><E><K><R><E><K><R><R><L><Q><Q><Q><E><L><R><E><K><R><A><Q><D><V><D><A><T><N><P><N><Y><E><I><M><C><M><I><R><D><F><R><G><S><L><D><Y><R><P><L><T><T><A><D><P><I><D><E><H><R><I><C><V><C><V><R><K><R><P><L><N><K><K><E><T><Q><M><K><D><L><D><V><I><T><I><P><S><K><D><V><V><M><V><H><E><P><K><Q><K><V><D><L><T><R><Y><L><E><N><Q><T><F><R><F><D><Y><A><F><D><D><S><A><P><N><E><M><V><Y><R><F><T><A><R><P><L><V><E><T><I><F><E><R><G><M><A><T><C><F><A><Y><G><Q><T><G><S><G><K><T><H><T><M><G><G><D><F><S><G><K><N><Q><D><C><S><K><G><I><Y><A><L><A><A><R><D><V><F><L><M><L><K><K><P><N><Y><K><K><L><E><L><Q><V><Y><A><T><F><F><E><I><Y><S><G><K><V><F><D><L><L><N><R><K><T><K><L><R><V><L><E><D><G><K><Q><Q><V><Q><V><V><G><L><Q><E><R><E><V><K><C><V><E><D><V><L><K><L><I><D><I><G><N><S><C><R><T><S><G><Q><T><S><A><N><A><H><S><S><R><S><H><A><V><F><Q><I><I><L><R><R><K><G><K><L><H><G><K><F><S><L><I><D><L><A><G><N><E><R><G><A><D><T><S><S><A><D><R><Q><T><R><L><E><G><A><E><I><N><K><S><L><L><A><L><K><E><C><I><R><A><L><G><R><N><K><P><H><T><P><F><R><A><S><K><L><T><Q><V><L><R><D><S><F><I><G><E><N><S><R><T><C><M><I><A><T><I><S><P><G><M><A><S><C><E><N><T><L><N><T><L><R><Y><A><N><R><V><K><E><L><T><V><D><P><T><A><A><G><D><V><R><P><I><M><H><H><P><P><N><Q><I><D><D><L><E><T><Q><W><G><V><G><S><S><P><Q><R><D><D><L><K><L><L><C><E><Q><N><E><E><E><V><S><P><Q><L><F><T><F><H><E><A><V><S><Q><M><V><E><M><E><E><Q><V><V><E><D><H><R><A><V><F><Q><E><S><I><R><W><L><E><D><E><K><A><L><L><E><M><T><E><E><V><D><Y><D><V><D><S><Y><A><T><Q><L><E><A><I><L><E><Q><K><I><D><I><L><T><E><L><R><D><K><V><K><S><F><R><A><A><L><Q><E><E><E><Q><A><S><K><Q><I><N><P><K><R><P><R><A><L> | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.<BOP> | O00139 |
Q9UKY3 | CES1P_HUMAN | Placental carboxylesterase 3 | Homo | <M><W><L><P><A><L><V><L><A><T><L><A><A><S><A><A><W><A><G><H><L><S><S><P><P><L><V><D><T><L><H><G><K><V><L><G><K><F><V><S><L><E><G><F><A><Q><P><V><A><V><F><L><G><I><P><F><A><K><P><P><L><G><P><L><R><F><T><L><P><Q><P><A><E><P><W><N><F><V><K><N><A><T><S><Y><P><P><M><F><T><Q><D><P><K><A><G><Q><L><I><S><E><L><F><T><N><R><K><E><N><I><P><L><K><L><S><E><D><C><L><Y><L><N><I><Y><T><P><A><D><L><T><K><K><N><R><L><P><V><M><V><W><I><H><G><G><G><L><M><V><G><A><A><S><T><Y><D><G><L><A><L><A><A><H><E><N><V><V><V><V><T><I><Q><Y><R><L><G><I><W><G><F><F><S><T><G><D><E><H><S><P><G><N><W><G><H><L><D><Q><L><A><A><L><H><W><V><Q><D><N><I><A><S><F><G><G><N><P><G><S><V><T><I><F><G><G><S><V><G><G><E><S><V><S><V><L><V><L><S><P><L><A><K><N><L><F><H><R><A><I><S><E><S><G><V><A><L><T><S><V><L><V><K><K><G><D><V><K><P><L><A><E><V><G><L><R><L><V><R><L><R><L><D><T><P><T><S><L><A><L><C><S> | Has no esterase activity.<BOP> | Q9UKY3 |
Q96S21 | RB40C_HUMAN | SOCS box-containing protein RAR3 | Homo | <M><G><S><Q><G><S><P><V><K><S><Y><D><Y><L><L><K><F><L><L><V><G><D><S><D><V><G><K><G><E><I><L><E><S><L><Q><D><G><A><A><E><S><P><Y><A><Y><S><N><G><I><D><Y><K><T><T><T><I><L><L><D><G><R><R><V><K><L><E><L><W><D><T><S><G><Q><G><R><F><C><T><I><F><R><S><Y><S><R><G><A><Q><G><I><L><L><V><Y><D><I><T><N><R><W><S><F><D><G><I><D><R><W><I><K><E><I><D><E><H><A><P><G><V><P><R><I><L><V><G><N><R><L><H><L><A><F><K><R><Q><V><P><T><E><Q><A><R><A><Y><A><E><K><N><C><M><T><F><F><E><V><S><P><L><C><N><F><N><V><I><E><S><F><T><E><L><S><R><I><V><L><M><R><H><G><M><E><K><I><W><R><P><N><R><V><F><S><L><Q><D><L><C><C><R><A><I><V><S><C><T><P><V><H><L><I><D><K><L><P><L><P><V><T><I><K><S><H><L><K><S><F><S><M><A><N><G><M><N><A><V><M><M><H><G><R><S><Y><S><L><A><S><G><A><G><G><G><G><S><K><G><N><S><L><K><R><S><K><S><I><R><P><P><Q><S><P><P><Q><N><C><S><R><S><N><C><K><I><S> | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP> | Q96S21 |
O75593 | FOXH1_HUMAN | Forkhead activin signal transducer 2 | Homo | <M><G><P><C><S><G><S><R><L><G><P><P><E><A><E><S><P><S><Q><P><P><K><R><R><K><K><R><Y><L><R><H><D><K><P><P><Y><T><Y><L><A><M><I><A><L><V><I><Q><A><A><P><S><R><R><L><K><L><A><Q><I><I><R><Q><V><Q><A><V><F><P><F><F><R><E><D><Y><E><G><W><K><D><S><I><R><H><N><L><S><S><N><R><C><F><R><K><V><P><K><D><P><A><K><P><Q><A><K><G><N><F><W><A><V><D><V><S><L><I><P><A><E><A><L><R><L><Q><N><T><A><L><C><R><R><W><Q><N><G><G><A><R><G><A><F><A><K><D><L><G><P><Y><V><L><H><G><R><P><Y><R><P><P><S><P><P><P><P><P><S><E><G><F><S><I><K><S><L><L><G><G><S><G><E><G><A><P><W><P><G><L><A><P><Q><S><S><P><V><P><A><G><T><G><N><S><G><E><E><A><V><P><T><P><P><L><P><S><S><E><R><P><L><W><P><L><C><P><L><P><G><P><T><R><V><E><G><E><T><V><Q><G><G><A><I><G><P><S><T><L><S><P><E><P><R><A><W><P><L><H><L><L><Q><G><T><A><V><P><G><G><R><S><S><G><G><H><R><A><S><L><W><G><Q><L><P><T><S><Y><L><P><I><Y><T><P><N><V><V><M><P><L><A><P><P><P><T><S><C><P><Q><C><P><S><T><S><P><A><Y><W><G><V><A><P><E><T><R><G><P><P><G><L><L><C><D><L><D><A><L><F><Q><G><V><P><P><N><K><S><I><Y><D><V><W><V><S><H><P><R><D><L><A><A><P><G><P><G><W><L><L><S><W><C><S><L> | Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).<BOP> | O75593 |
O43766 | LIAS_HUMAN | Lipoic acid synthase | Homo | <M><S><L><R><C><G><D><A><A><R><T><L><G><P><R><V><F><G><R><Y><F><C><S><P><V><R><P><L><S><S><L><P><D><K><K><K><E><L><L><Q><N><G><P><D><L><Q><D><F><V><S><G><D><L><A><D><R><S><T><W><D><E><Y><K><G><N><L><K><R><Q><K><G><E><R><L><R><L><P><P><W><L><K><T><E><I><P><M><G><K><N><Y><N><K><L><K><N><T><L><R><N><L><N><L><H><T><V><C><E><E><A><R><C><P><N><I><G><E><C><W><G><G><G><E><Y><A><T><A><T><A><T><I><M><L><M><G><D><T><C><T><R><G><C><R><F><C><S><V><K><T><A><R><N><P><P><P><L><D><A><S><E><P><Y><N><T><A><K><A><I><A><E><W><G><L><D><Y><V><V><L><T><S><V><D><R><D><D><M><P><D><G><G><A><E><H><I><A><K><T><V><S><Y><L><K><E><R><N><P><K><I><L><V><E><C><L><T><P><D><F><R><G><D><L><K><A><I><E><K><V><A><L><S><G><L><D><V><Y><A><H><N><V><E><T><V><P><E><L><Q><S><K><V><R><D><P><R><A><N><F><D><Q><S><L><R><V><L><K><H><A><K><K><V><Q><P><D><V><I><S><K><T><S><I><M><L><G><L><G><E><N><D><E><Q><V><Y><A><T><M><K><A><L><R><E><A><D><V><D><C><L><T><L><G><Q><Y><M><Q><P><T><R><R><H><L><K><V><E><E><Y><I><T><P><E><K><F><K><Y><W><E><K><V><G><N><E><L><G><F><H><Y><T><A><S><G><P><L><V><R><S><S><Y><K><A><G><E><F><F><L><K><N><L><V><A><K><R><K><T><K><D><L> | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.<BOP> | O43766 |
Q9ULZ2 | STAP1_HUMAN | Stem cell adaptor protein 1 | Homo | <M><M><A><K><K><P><P><K><P><A><P><R><R><I><F><Q><E><R><L><K><I><T><A><L><P><L><Y><F><E><G><F><L><L><I><K><R><S><G><Y><R><E><Y><E><H><Y><W><T><E><L><R><G><T><T><L><F><F><Y><T><D><K><K><S><I><I><Y><V><D><K><L><D><I><V><D><L><T><C><L><T><E><Q><N><S><T><E><K><N><C><A><K><F><T><L><V><L><P><K><E><E><V><Q><L><K><T><E><N><T><E><S><G><E><E><W><R><G><F><I><L><T><V><T><E><L><S><V><P><Q><N><V><S><L><L><P><G><Q><V><I><K><L><H><E><V><L><E><R><E><K><K><R><R><I><E><T><E><Q><S><T><S><V><E><K><E><K><E><P><T><E><D><Y><V><D><V><L><N><P><M><P><A><C><F><Y><T><V><S><R><K><E><A><T><E><M><L><Q><K><N><P><S><L><G><N><M><I><L><R><P><G><S><D><S><R><N><Y><S><I><T><I><R><Q><E><I><D><I><P><R><I><K><H><Y><K><V><M><S><V><G><Q><N><Y><T><I><E><L><E><K><P><V><T><L><P><N><L><F><S><V><I><D><Y><F><V><K><E><T><R><G><N><L><R><P><F><I><C><S><T><D><E><N><T><G><Q><E><P><S><M><E><G><R><S><E><K><L><K><K><N><P><H><I><A> | In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<BOP> | Q9ULZ2 |
O60858 | TRI13_HUMAN | Tripartite motif-containing protein 13 | Homo | <M><E><L><L><E><E><D><L><T><C><P><I><C><C><S><L><F><D><D><P><R><V><L><P><C><S><H><N><F><C><K><K><C><L><E><G><I><L><E><G><S><V><R><N><S><L><W><R><P><A><P><F><K><C><P><T><C><R><K><E><T><S><A><T><G><I><N><S><L><Q><V><N><Y><S><L><K><G><I><V><E><K><Y><N><K><I><K><I><S><P><K><M><P><V><C><K><G><H><L><G><Q><P><L><N><I><F><C><L><T><D><M><Q><L><I><C><G><I><C><A><T><R><G><E><H><T><K><H><V><F><C><S><I><E><D><A><Y><A><Q><E><R><D><A><F><E><S><L><F><Q><S><F><E><T><W><R><R><G><D><A><L><S><R><L><D><T><L><E><T><S><K><R><K><S><L><Q><L><L><T><K><D><S><D><K><V><K><E><F><F><E><K><L><Q><H><T><L><D><Q><K><K><N><E><I><L><S><D><F><E><T><M><K><L><A><V><M><Q><A><Y><D><P><E><I><N><K><L><N><T><I><L><Q><E><Q><R><M><A><F><N><I><A><E><A><F><K><D><V><S><E><P><I><V><F><L><Q><Q><M><Q><E><F><R><E><K><I><K><V><I><K><E><T><P><L><P><P><S><N><L><P><A><S><P><L><M><K><N><F><D><T><S><Q><W><E><D><I><K><L><V><D><V><D><K><L><S><L><P><Q><D><T><G><T><F><I><S><K><I><P><W><S><F><Y><K><L><F><L><L><I><L><L><L><G><L><V><I><V><F><G><P><T><M><F><L><E><W><S><L><F><D><D><L><A><T><W><K><G><C><L><S><N><F><S><S><Y><L><T><K><T><A><D><F><I><E><Q><S><V><F><Y><W><E><Q><V><T><D><G><F><F><I><F><N><E><R><F><K><N><F><T><L><V><V><L><N><N><V><A><E><F><V><C><K><Y><K><L><L> | Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor . Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation . Participates as well in T-cell receptor-mediated NF-kappa-B activation . In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B .<BOP> | O60858 |
P20645 | MPRD_HUMAN | 46 kDa mannose 6-phosphate receptor | Homo | <M><F><P><F><Y><S><C><W><R><T><G><L><L><L><L><L><L><A><V><A><V><R><E><S><W><Q><T><E><E><K><T><C><D><L><V><G><E><K><G><K><E><S><E><K><E><L><A><L><V><K><R><L><K><P><L><F><N><K><S><F><E><S><T><V><G><Q><G><S><D><T><Y><I><Y><I><F><R><V><C><R><E><A><G><N><H><T><S><G><A><G><L><V><Q><I><N><K><S><N><G><K><E><T><V><V><G><R><L><N><E><T><H><I><F><N><G><S><N><W><I><M><L><I><Y><K><G><G><D><E><Y><D><N><H><C><G><K><E><Q><R><R><A><V><V><M><I><S><C><N><R><H><T><L><A><D><N><F><N><P><V><S><E><E><R><G><K><V><Q><D><C><F><Y><L><F><E><M><D><S><S><L><A><C><S><P><E><I><S><H><L><S><V><G><S><I><L><L><V><T><F><A><S><L><V><A><V><Y><V><V><G><G><F><L><Y><Q><R><L><V><V><G><A><K><G><M><E><Q><F><P><H><L><A><F><W><Q><D><L><G><N><L><V><A><D><G><C><D><F><V><C><R><S><K><P><R><N><V><P><A><A><Y><R><G><V><G><D><D><Q><L><G><E><E><S><E><E><R><D><D><H><L><L><P><M> | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.<BOP> | P20645 |
Q6UX82 | LYPD8_HUMAN | Ly6/PLAUR domain-containing protein 8 | Homo | <M><K><G><I><L><V><A><G><I><T><A><V><L><V><A><A><V><E><S><L><S><C><V><Q><C><N><S><W><E><K><S><C><V><N><S><I><A><S><E><C><P><S><H><A><N><T><S><C><I><S><S><S><A><S><S><S><L><E><T><P><V><R><L><Y><Q><N><M><F><C><S><A><E><N><C><S><E><E><T><H><I><T><A><F><T><V><H><V><S><A><E><E><H><F><H><F><V><S><Q><C><C><Q><G><K><E><C><S><N><T><S><D><A><L><D><P><P><L><K><N><V><S><S><N><A><E><C><P><A><C><Y><E><S><N><G><T><S><C><H><G><K><P><W><K><C><Y><E><E><E><Q><C><V><F><L><V><A><E><L><K><N><D><I><E><S><K><S><L><V><L><K><G><C><S><N><V><S><N><A><T><C><Q><F><L><S><G><E><N><K><T><L><G><G><V><I><F><R><K><F><E><C><A><N><V><N><S><L><T><P><T><S><A><P><T><T><S><H><N><V><G><S><K><A><S><L><Y><L><L><A><L><A><S><L><L><L><R><G><L><L><P> | Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.<BOP> | Q6UX82 |
Q12983 | BNIP3_HUMAN | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Homo | <M><S><Q><N><G><A><P><G><M><Q><E><E><S><L><Q><G><S><W><V><E><L><H><F><S><N><N><G><N><G><G><S><V><P><A><S><V><S><I><Y><N><G><D><M><E><K><I><L><L><D><A><Q><H><E><S><G><R><S><S><S><K><S><S><H><C><D><S><P><P><R><S><Q><T><P><Q><D><T><N><R><A><S><E><T><D><T><H><S><I><G><E><K><N><S><S><Q><S><E><E><D><D><I><E><R><R><K><E><V><E><S><I><L><K><K><N><S><D><W><I><W><D><W><S><S><R><P><E><N><I><P><P><K><E><F><L><F><K><H><P><K><R><T><A><T><L><S><M><R><N><T><S><V><M><K><K><G><G><I><F><S><A><E><F><L><K><V><F><L><P><S><L><L><L><S><H><L><L><A><I><G><L><G><I><Y><I><G><R><R><L><T><T><S><T><S><T><F> | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.<BOP> | Q12983 |
O00571 | DDX3X_HUMAN | Helicase-like protein 2 | Homo | <M><S><H><V><A><V><E><N><A><L><G><L><D><Q><Q><F><A><G><L><D><L><N><S><S><D><N><Q><S><G><G><S><T><A><S><K><G><R><Y><I><P><P><H><L><R><N><R><E><A><T><K><G><F><Y><D><K><D><S><S><G><W><S><S><S><K><D><K><D><A><Y><S><S><F><G><S><R><S><D><S><R><G><K><S><S><F><F><S><D><R><G><S><G><S><R><G><R><F><D><D><R><G><R><S><D><Y><D><G><I><G><S><R><G><D><R><S><G><F><G><K><F><E><R><G><G><N><S><R><W><C><D><K><S><D><E><D><D><W><S><K><P><L><P><P><S><E><R><L><E><Q><E><L><F><S><G><G><N><T><G><I><N><F><E><K><Y><D><D><I><P><V><E><A><T><G><N><N><C><P><P><H><I><E><S><F><S><D><V><E><M><G><E><I><I><M><G><N><I><E><L><T><R><Y><T><R><P><T><P><V><Q><K><H><A><I><P><I><I><K><E><K><R><D><L><M><A><C><A><Q><T><G><S><G><K><T><A><A><F><L><L><P><I><L><S><Q><I><Y><S><D><G><P><G><E><A><L><R><A><M><K><E><N><G><R><Y><G><R><R><K><Q><Y><P><I><S><L><V><L><A><P><T><R><E><L><A><V><Q><I><Y><E><E><A><R><K><F><S><Y><R><S><R><V><R><P><C><V><V><Y><G><G><A><D><I><G><Q><Q><I><R><D><L><E><R><G><C><H><L><L><V><A><T><P><G><R><L><V><D><M><M><E><R><G><K><I><G><L><D><F><C><K><Y><L><V><L><D><E><A><D><R><M><L><D><M><G><F><E><P><Q><I><R><R><I><V><E><Q><D><T><M><P><P><K><G><V><R><H><T><M><M><F><S><A><T><F><P><K><E><I><Q><M><L><A><R><D><F><L><D><E><Y><I><F><L><A><V><G><R><V><G><S><T><S><E><N><I><T><Q><K><V><V><W><V><E><E><S><D><K><R><S><F><L><L><D><L><L><N><A><T><G><K><D><S><L><T><L><V><F><V><E><T><K><K><G><A><D><S><L><E><D><F><L><Y><H><E><G><Y><A><C><T><S><I><H><G><D><R><S><Q><R><D><R><E><E><A><L><H><Q><F><R><S><G><K><S><P><I><L><V><A><T><A><V><A><A><R><G><L><D><I><S><N><V><K><H><V><I><N><F><D><L><P><S><D><I><E><E><Y><V><H><R><I><G><R><T><G><R><V><G><N><L><G><L><A><T><S><F><F><N><E><R><N><I><N><I><T><K><D><L><L><D><L><L><V><E><A><K><Q><E><V><P><S><W><L><E><N><M><A><Y><E><H><H><Y><K><G><S><S><R><G><R><S><K><S><S><R><F><S><G><G><F><G><A><R><D><Y><R><Q><S><S><G><A><S><S><S><S><F><S><S><S><R><A><S><S><S><R><S><G><G><G><G><H><G><S><S><R><G><F><G><G><G><G><Y><G><G><F><Y><N><S><D><G><Y><G><G><N><Y><N><S><Q><G><V><D><W><W><G><N> | (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication.<BOP> | O00571 |
Q15723 | ELF2_HUMAN | New ETS-related factor | Homo | <M><T><S><A><V><V><D><S><G><G><T><I><L><E><L><S><S><N><G><V><E><N><Q><E><E><S><E><K><V><S><E><Y><P><A><V><I><V><E><P><V><P><S><A><R><L><E><Q><G><Y><A><A><Q><V><L><V><Y><D><D><E><T><Y><M><M><Q><D><V><A><E><E><Q><E><V><E><T><E><N><V><E><T><V><E><A><S><V><H><S><S><N><A><H><C><T><D><K><T><I><E><A><A><E><A><L><L><H><M><E><S><P><T><C><L><R><D><S><R><S><P><V><E><V><F><V><P><P><C><V><S><T><P><E><F><I><H><A><A><M><R><P><D><V><I><T><E><T><V><V><E><V><S><T><E><E><S><E><P><M><D><T><S><P><I><P><T><S><P><D><S><H><E><P><M><K><K><K><K><V><G><R><K><P><K><T><Q><Q><S><P><I><S><N><G><S><P><E><L><G><I><K><K><K><P><R><E><G><K><G><N><T><T><Y><L><W><E><F><L><L><D><L><L><Q><D><K><N><T><C><P><R><Y><I><K><W><T><Q><R><E><K><G><I><F><K><L><V><D><S><K><A><V><S><K><L><W><G><K><H><K><N><K><P><D><M><N><Y><E><T><M><G><R><A><L><R><Y><Y><Y><Q><R><G><I><L><A><K><V><E><G><Q><R><L><V><Y><Q><F><K><D><M><P><K><N><I><V><V><I><D><D><D><K><S><E><T><C><N><E><D><L><A><G><T><T><D><E><K><S><L><E><R><V><S><L><S><A><E><S><L><L><K><A><A><S><S><V><R><S><G><K><N><S><S><P><I><N><C><S><R><A><E><K><G><V><A><R><V><V><N><I><T><S><P><G><H><D><A><S><S><R><S><P><T><T><T><A><S><V><S><A><T><A><A><P><R><T><V><R><V><A><M><Q><V><P><V><V><M><T><S><L><G><Q><K><I><S><T><V><A><V><Q><S><V><N><A><G><A><P><L><I><T><S><T><S><P><T><T><A><T><S><P><K><V><V><I><Q><T><I><P><T><V><M><P><A><S><T><E><N><G><D><K><I><T><M><Q><P><A><K><I><I><T><I><P><A><T><Q><L><A><Q><C><Q><L><Q><T><K><S><N><L><T><G><S><G><S><I><N><I><V><G><T><P><L><A><V><R><A><L><T><P><V><S><I><A><H><G><T><P><V><M><R><L><S><M><P><T><Q><Q><A><S><G><Q><T><P><P><R><V><I><S><A><V><I><K><G><P><E><V><K><S><E><A><V><A><K><K><Q><E><H><D><V><K><T><L><Q><L><V><E><E><K><P><A><D><G><N><K><T><V><T><H><V><V><V><V><S><A><P><S><A><I><A><L><P><V><T><M><K><T><E><G><L><V><T><C><E><K> | Isoform 2 may function in repression of RUNX1-mediated transactivation.<BOP> | Q15723 |
Q96RD2 | O52B2_HUMAN | Olfactory receptor OR11-70 | Homo | <M><S><H><T><N><V><T><I><F><H><P><A><V><F><V><L><P><G><I><P><G><L><E><A><Y><H><I><W><L><S><I><P><L><C><L><I><Y><I><T><A><V><L><G><N><S><I><L><I><V><V><I><V><M><E><R><N><L><H><V><P><M><Y><F><F><L><S><M><L><A><V><M><D><I><L><L><S><T><T><T><V><P><K><A><L><A><I><F><W><L><Q><A><H><N><I><A><F><D><A><C><V><T><Q><G><F><F><V><H><M><M><F><V><G><E><S><A><I><L><L><A><M><A><F><D><R><F><V><A><I><C><A><P><L><R><Y><T><T><V><L><T><W><P><V><V><G><R><I><A><L><A><V><I><T><R><S><F><C><I><I><F><P><V><I><F><L><L><K><R><L><P><F><C><L><T><N><I><V><P><H><S><Y><C><E><H><I><G><V><A><R><L><A><C><A><D><I><T><V><N><I><W><Y><G><F><S><V><P><I><V><M><V><I><L><D><V><I><L><I><A><V><S><Y><S><L><I><L><R><A><V><F><R><L><P><S><Q><D><A><R><H><K><A><L><S><T><C><G><S><H><L><C><V><I><L><M><F><Y><V><P><S><F><F><T><L><L><T><H><H><F><G><R><N><I><P><Q><H><V><H><I><L><L><A><N><L><Y><V><A><V><P><P><M><L><N><P><I><V><Y><G><V><K><T><K><Q><I><R><E><G><V><A><H><R><F><F><D><I><K><T><W><C><C><T><S><P><L><G><S> | Odorant receptor.<BOP> | Q96RD2 |
A8MUP2 | CSKMT_HUMAN | Methyltransferase-like protein 12, mitochondrial | Homo | <M><A><A><L><R><R><M><L><H><L><P><S><L><M><M><G><T><C><R><P><F><A><G><S><L><A><D><S><C><L><A><D><R><C><L><W><D><R><L><H><A><Q><P><R><L><G><T><V><P><T><F><D><W><F><F><G><Y><D><E><V><Q><G><L><L><L><P><L><L><Q><E><A><Q><A><A><S><P><L><R><V><L><D><V><G><C><G><T><S><S><L><C><T><G><L><Y><T><K><S><P><H><P><V><D><V><L><G><V><D><F><S><P><V><A><V><A><H><M><N><S><L><L><E><G><G><P><G><Q><T><P><L><C><P><G><H><P><A><S><S><L><H><F><M><H><A><D><A><Q><N><L><G><A><V><A><S><S><G><S><F><Q><L><L><L><D><K><G><T><W><D><A><V><A><R><G><G><L><P><R><A><Y><Q><L><L><S><E><C><L><R><V><L><N><P><Q><G><T><L><I><Q><F><S><D><E><D><P><D><V><R><L><P><C><L><E><Q><G><S><Y><G><W><T><V><T><V><Q><E><L><G><P><F><R><G><I><T><Y><F><A><Y><L><I><Q><G><S><H> | Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria . Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event .<BOP> | A8MUP2 |
P80075 | CCL8_HUMAN | MCP-2(6-76) | Homo | <M><K><V><S><A><A><L><L><C><L><L><L><M><A><A><T><F><S><P><Q><G><L><A><Q><P><D><S><V><S><I><P><I><T><C><C><F><N><V><I><N><R><K><I><P><I><Q><R><L><E><S><Y><T><R><I><T><N><I><Q><C><P><K><E><A><V><I><F><K><T><K><R><G><K><E><V><C><A><D><P><K><E><R><W><V><R><D><S><M><K><H><L><D><Q><I><F><Q><N><L><K><P> | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.<BOP> | P80075 |
Q13506 | NAB1_HUMAN | Transcriptional regulatory protein p54 | Homo | <M><A><A><A><L><P><R><T><L><G><E><L><Q><L><Y><R><I><L><Q><K><A><N><L><L><S><Y><F><D><A><F><I><Q><Q><G><G><D><D><V><Q><Q><L><C><E><A><G><E><E><E><F><L><E><I><M><A><L><V><G><M><A><S><K><P><L><H><V><R><R><L><Q><K><A><L><R><D><W><V><T><N><P><G><L><F><N><Q><P><L><T><S><L><P><V><S><S><I><P><I><Y><K><L><P><E><G><S><P><T><W><L><G><I><S><C><S><S><Y><E><R><S><S><N><A><R><E><P><H><L><K><I><P><K><C><A><A><T><T><C><V><Q><S><L><G><Q><G><K><S><D><V><V><G><S><L><A><L><Q><S><V><G><E><S><R><L><W><Q><G><H><H><A><T><E><S><E><H><S><L><S><P><A><D><L><G><S><P><A><S><P><K><E><S><S><E><A><L><D><A><A><A><A><L><S><V><A><E><C><V><E><R><M><A><P><T><L><P><K><S><D><L><N><E><V><K><E><L><L><K><T><N><K><K><L><A><K><M><I><G><H><I><F><E><M><N><D><D><D><P><H><K><E><E><E><I><R><K><Y><S><A><I><Y><G><R><F><D><S><K><R><K><D><G><K><H><L><T><L><H><E><L><T><V><N><E><A><A><A><Q><L><C><V><K><D><N><A><L><L><T><R><R><D><E><L><F><A><L><A><R><Q><I><S><R><E><V><T><Y><K><Y><T><Y><R><T><T><K><S><K><C><G><E><R><D><E><L><S><P><K><R><I><K><V><E><D><G><F><P><D><F><Q><D><S><V><Q><T><L><F><Q><Q><A><R><A><K><S><E><E><L><A><A><L><S><S><Q><Q><P><E><K><V><M><A><K><Q><M><E><F><L><C><N><Q><A><G><Y><E><R><L><Q><H><A><E><R><R><L><S><A><G><L><Y><R><Q><S><S><E><E><H><S><P><N><G><L><T><S><D><N><S><D><G><Q><G><E><R><P><L><N><L><R><M><P><N><L><Q><N><R><Q><P><H><H><F><V><V><D><G><E><L><S><R><L><Y><P><S><E><A><K><S><H><S><S><E><S><L><G><I><L><K><D><Y><P><H><S><A><F><T><L><E><K><K><V><I><K><T><E><P><E><D><S><R> | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.<BOP> | Q13506 |
Q8WVQ1 | CANT1_HUMAN | Putative NF-kappa-B-activating protein 107 | Homo | <M><P><V><Q><L><S><E><H><P><E><W><N><E><S><M><H><S><L><R><I><S><V><G><G><L><P><V><L><A><S><M><T><K><A><A><D><P><R><F><R><P><R><W><K><V><I><L><T><F><F><V><G><A><A><I><L><W><L><L><C><S><H><R><P><A><P><G><R><P><P><T><H><N><A><H><N><W><R><L><G><Q><A><P><A><N><W><Y><N><D><T><Y><P><L><S><P><P><Q><R><T><P><A><G><I><R><Y><R><I><A><V><I><A><D><L><D><T><E><S><R><A><Q><E><E><N><T><W><F><S><Y><L><K><K><G><Y><L><T><L><S><D><S><G><D><K><V><A><V><E><W><D><K><D><H><G><V><L><E><S><H><L><A><E><K><G><R><G><M><E><L><S><D><L><I><V><F><N><G><K><L><Y><S><V><D><D><R><T><G><V><V><Y><Q><I><E><G><S><K><A><V><P><W><V><I><L><S><D><G><D><G><T><V><E><K><G><F><K><A><E><W><L><A><V><K><D><E><R><L><Y><V><G><G><L><G><K><E><W><T><T><T><T><G><D><V><V><N><E><N><P><E><W><V><K><V><V><G><Y><K><G><S><V><D><H><E><N><W><V><S><N><Y><N><A><L><R><A><A><A><G><I><Q><P><P><G><Y><L><I><H><E><S><A><C><W><S><D><T><L><Q><R><W><F><F><L><P><R><R><A><S><Q><E><R><Y><S><E><K><D><D><E><R><K><G><A><N><L><L><L><S><A><S><P><D><F><G><D><I><A><V><S><H><V><G><A><V><V><P><T><H><G><F><S><S><F><K><F><I><P><N><T><D><D><Q><I><I><V><A><L><K><S><E><E><D><S><G><R><V><A><S><Y><I><M><A><F><T><L><D><G><R><F><L><L><P><E><T><K><I><G><S><V><K><Y><E><G><I><E><F><I> | Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP . Involved in proteoglycan synthesis .<BOP> | Q8WVQ1 |
O95685 | PPR3D_HUMAN | Protein phosphatase 1-binding subunit R6 | Homo | <M><S><R><G><P><S><S><A><V><L><P><S><A><L><G><S><R><K><L><G><P><R><S><L><S><C><L><S><D><L><D><G><G><V><A><L><E><P><R><A><C><R><P><P><G><S><P><G><R><A><P><P><P><T><P><A><P><S><G><C><D><P><R><L><R><P><I><I><L><R><R><A><R><S><L><P><S><S><P><E><R><R><Q><K><A><A><G><A><P><G><A><A><C><R><P><G><C><S><Q><K><L><R><V><R><F><A><D><A><L><G><L><E><L><A><Q><V><K><V><F><N><A><G><D><D><P><S><V><P><L><H><V><L><S><R><L><A><I><N><S><D><L><C><C><S><S><Q><D><L><E><F><T><L><H><C><L><V><P><D><F><P><P><P><V><E><A><A><D><F><G><E><R><L><Q><R><Q><L><V><C><L><E><R><V><T><C><S><D><L><G><I><S><G><T><V><R><V><C><N><V><A><F><E><K><Q><V><A><V><R><Y><T><F><S><G><W><R><S><T><H><E><A><V><A><R><W><R><G><P><A><G><P><E><G><T><E><D><V><F><T><F><G><F><P><V><P><P><F><L><L><E><L><G><S><R><V><H><F><A><V><R><Y><Q><V><A><G><A><E><Y><W><D><N><N><D><H><R><D><Y><S><L><T><C><R><N><H><A><L><H><M><P><R><G><E><C><E><E><S><W><I><H><F><I> | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.<BOP> | O95685 |
Q8TED9 | AF1L1_HUMAN | Actin filament-associated protein 1-like 1 | Homo | <M><D><R><G><Q><V><L><E><Q><L><L><P><E><L><T><G><L><L><S><L><L><D><H><E><Y><L><S><D><T><T><L><E><K><K><M><A><V><A><S><I><L><Q><S><L><Q><P><L><P><A><K><E><V><S><Y><L><Y><V><N><T><A><D><L><H><S><G><P><S><F><V><E><S><L><F><E><E><F><D><C><D><L><S><D><L><R><D><M><P><E><D><D><G><E><P><S><K><G><A><S><P><E><L><A><K><S><P><R><L><R><N><A><A><D><L><P><P><P><L><P><N><K><P><P><P><E><D><Y><Y><E><E><A><L><P><L><G><P><G><K><S><P><E><Y><I><S><S><H><N><G><C><S><P><S><H><S><I><V><D><G><Y><Y><E><D><A><D><S><S><Y><P><A><T><R><V><N><G><E><L><K><S><S><Y><N><D><S><D><A><M><S><S><S><Y><E><S><Y><D><E><E><E><E><E><G><K><S><P><Q><P><R><H><Q><W><P><S><E><E><A><S><M><H><L><V><R><E><C><R><I><C><A><F><L><L><R><K><K><R><F><G><Q><W><A><K><Q><L><T><V><I><R><E><D><Q><L><L><C><Y><K><S><S><K><D><R><Q><P><H><L><R><L><A><L><D><T><C><S><I><I><Y><V><P><K><D><S><R><H><K><R><H><E><L><R><F><T><Q><G><A><T><E><V><L><V><L><A><L><Q><S><R><E><Q><A><E><E><W><L><K><V><I><R><E><V><S><K><P><V><G><G><A><E><G><V><E><V><P><R><S><P><V><L><L><C><K><L><D><L><D><K><R><L><S><Q><E><K><Q><T><S><D><S><D><S><V><G><V><G><D><N><C><S><T><L><G><R><R><E><T><C><D><H><G><K><G><K><K><S><S><L><A><E><L><K><G><S><M><S><R><A><A><G><R><K><I><T><R><I><I><G><F><S><K><K><K><T><L><A><D><D><L><Q><T><S><S><T><E><E><E><V><P><C><C><G><Y><L><N><V><L><V><N><Q><G><W><K><E><R><W><C><R><L><K><C><N><T><L><Y><F><H><K><D><H><M><D><L><R><T><H><V><N><A><I><A><L><Q><G><C><E><V><A><P><G><F><G><P><R><H><P><F><A><F><R><I><L><R><N><R><Q><E><V><A><I><L><E><A><S><C><S><E><D><M><G><R><W><L><G><L><L><L><V><E><M><G><S><R><V><T><P><E><A><L><H><Y><D><Y><V><D><V><E><T><L><T><S><I><V><S><A><G><R><N><S><F><L><Y><A><R><S><C><Q><N><Q><W><P><E><P><R><V><Y><D><D><V><P><Y><E><K><M><Q><D><E><E><P><E><R><P><T><G><A><Q><V><K><R><H><A><S><S><C><S><E><K><S><H><R><V><D><P><Q><V><K><V><K><R><H><A><S><S><A><N><Q><Y><K><Y><G><K><N><R><A><E><E><D><A><R><R><Y><L><V><E><K><E><K><L><E><K><E><K><E><T><I><R><T><E><L><I><A><L><R><Q><E><K><R><E><L><K><E><A><I><R><S><S><P><G><A><K><L><K><A><L><E><E><A><V><A><T><L><E><A><Q><C><R><A><K><E><E><R><R><I><D><L><E><L><K><L><V><A><V><K><E><R><L><Q><Q><S><L><A><G><G><P><A><L><G><L><S><V><S><S><K><P><K><S><G><E><T><A><N><K><P><Q><N><S><V><P><E><Q><P><L><P><V><N><C><V><S><E><L><R><K><R><S><P><S><I><V><A><S><N><Q><G><R><V><L><Q><K><A><K><E><W><E><M><K><K><T> | May be involved in podosome and invadosome formation.<BOP> | Q8TED9 |
Q9Y2T4 | 2ABG_HUMAN | PP2A subunit B isoform gamma | Homo | <M><G><E><D><T><D><T><R><K><I><N><H><S><F><L><R><D><H><S><Y><V><T><E><A><D><I><I><S><T><V><E><F><N><H><T><G><E><L><L><A><T><G><D><K><G><G><R><V><V><I><F><Q><R><E><P><E><S><K><N><A><P><H><S><Q><G><E><Y><D><V><Y><S><T><F><Q><S><H><E><P><E><F><D><Y><L><K><S><L><E><I><E><E><K><I><N><K><I><K><W><L><P><Q><Q><N><A><A><H><S><L><L><S><T><N><D><K><T><I><K><L><W><K><I><T><E><R><D><K><R><P><E><G><Y><N><L><K><D><E><E><G><K><L><K><D><L><S><T><V><T><S><L><Q><V><P><V><L><K><P><M><D><L><M><V><E><V><S><P><R><R><I><F><A><N><G><H><T><Y><H><I><N><S><I><S><V><N><S><D><C><E><T><Y><M><S><A><D><D><L><R><I><N><L><W><H><L><A><I><T><D><R><S><F><N><I><V><D><I><K><P><A><N><M><E><D><L><T><E><V><I><T><A><S><E><F><H><P><H><H><C><N><L><F><V><Y><S><S><S><K><G><S><L><R><L><C><D><M><R><A><A><A><L><C><D><K><H><S><K><L><F><E><E><P><E><D><P><S><N><R><S><F><F><S><E><I><I><S><S><V><S><D><V><K><F><S><H><S><G><R><Y><M><L><T><R><D><Y><L><T><V><K><V><W><D><L><N><M><E><A><R><P><I><E><T><Y><Q><V><H><D><Y><L><R><S><K><L><C><S><L><Y><E><N><D><C><I><F><D><K><F><E><C><A><W><N><G><S><D><S><V><I><M><T><G><A><Y><N><N><F><F><R><M><F><D><R><N><T><K><R><D><V><T><L><E><A><S><R><E><S><S><K><P><R><A><V><L><K><P><R><R><V><C><V><G><G><K><R><R><R><D><D><I><S><V><D><S><L><D><F><T><K><K><I><L><H><T><A><W><H><P><A><E><N><I><I><A><I><A><A><T><N><N><L><Y><I><F><Q><D><K><V><N><S><D><M><H> | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.<BOP> | Q9Y2T4 |
P01570 | IFN14_HUMAN | Interferon lambda-2-H | Homo | <M><A><L><P><F><A><L><M><M><A><L><V><V><L><S><C><K><S><S><C><S><L><G><C><N><L><S><Q><T><H><S><L><N><N><R><R><T><L><M><L><M><A><Q><M><R><R><I><S><P><F><S><C><L><K><D><R><H><D><F><E><F><P><Q><E><E><F><D><G><N><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><M><Q><Q><T><F><N><L><F><S><T><K><N><S><S><A><A><W><D><E><T><L><L><E><K><F><Y><I><E><L><F><Q><Q><M><N><D><L><E><A><C><V><I><Q><E><V><G><V><E><E><T><P><L><M><N><E><D><S><I><L><A><V><K><K><Y><F><Q><R><I><T><L><Y><L><M><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><L><S><F><S><T><N><L><Q><K><R><L><R><R><K><D> | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP> | P01570 |
Q96Q40 | CDK15_HUMAN | Serine/threonine-protein kinase PFTAIRE-2 | Homo | <M><G><Q><E><L><C><A><K><T><V><Q><P><G><C><S><C><Y><H><C><S><E><G><G><E><A><H><S><C><R><R><S><Q><P><E><T><T><E><A><A><F><K><L><T><D><L><K><E><A><S><C><S><M><T><S><F><H><P><R><G><L><Q><A><A><R><A><Q><K><F><K><S><K><R><P><R><S><N><S><D><C><F><Q><E><E><D><L><R><Q><G><F><Q><W><R><K><S><L><P><F><G><A><A><S><S><Y><L><N><L><E><K><L><G><E><G><S><Y><A><T><V><Y><K><G><I><S><R><I><N><G><Q><L><V><A><L><K><V><I><S><M><N><A><E><E><G><V><P><F><T><A><I><R><E><A><S><L><L><K><G><L><K><H><A><N><I><V><L><L><H><D><I><I><H><T><K><E><T><L><T><F><V><F><E><Y><M><H><T><D><L><A><Q><Y><M><S><Q><H><P><G><G><L><H><P><H><N><V><R><L><F><M><F><Q><L><L><R><G><L><A><Y><I><H><H><Q><H><V><L><H><R><D><L><K><P><Q><N><L><L><I><S><H><L><G><E><L><K><L><A><D><F><G><L><A><R><A><K><S><I><P><S><Q><T><Y><S><S><E><V><V><T><L><W><Y><R><P><P><D><A><L><L><G><A><T><E><Y><S><S><E><L><D><I><W><G><A><G><C><I><F><I><E><M><F><Q><G><Q><P><L><F><P><G><V><S><N><I><L><E><Q><L><E><K><I><W><E><V><L><G><V><P><T><E><D><T><W><P><G><V><S><K><L><P><N><Y><N><P><E><W><F><P><L><P><T><P><R><S><L><H><V><V><W><N><R><L><G><R><V><P><E><A><E><D><L><A><S><Q><M><L><K><G><F><P><R><D><R><V><S><A><Q><E><A><L><V><H><D><Y><F><S><A><L><P><S><Q><L><Y><Q><L><P><D><E><E><S><L><F><T><V><S><G><V><R><L><K><P><E><M><C><D><L><L><A><S><Y><Q><K><G><H><H><P><A><Q><F><S><K><C><W> | Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.<BOP> | Q96Q40 |
Q9Y4P8 | WIPI2_HUMAN | WIPI49-like protein 2 | Homo | <M><N><L><A><S><Q><S><G><E><A><G><A><G><Q><L><L><F><A><N><F><N><Q><D><N><T><E><V><K><G><A><S><R><A><A><G><L><G><R><R><A><V><V><W><S><L><A><V><G><S><K><S><G><Y><K><F><F><S><L><S><S><V><D><K><L><E><Q><I><Y><E><C><T><D><T><E><D><V><C><I><V><E><R><L><F><S><S><S><L><V><A><I><V><S><L><K><A><P><R><K><L><K><V><C><H><F><K><K><G><T><E><I><C><N><Y><S><Y><S><N><T><I><L><A><V><K><L><N><R><Q><R><L><I><V><C><L><E><E><S><L><Y><I><H><N><I><R><D><M><K><V><L><H><T><I><R><E><T><P><P><N><P><A><G><L><C><A><L><S><I><N><N><D><N><C><Y><L><A><Y><P><G><S><A><T><I><G><E><V><Q><V><F><D><T><I><N><L><R><A><A><N><M><I><P><A><H><D><S><P><L><A><A><L><A><F><D><A><S><G><T><K><L><A><T><A><S><E><K><G><T><V><I><R><V><F><S><I><P><E><G><Q><K><L><F><E><F><R><R><G><V><K><R><C><V><S><I><C><S><L><A><F><S><M><D><G><M><F><L><S><A><S><S><N><T><E><T><V><H><I><F><K><L><E><T><V><K><E><K><P><P><E><E><P><T><T><W><T><G><Y><F><G><K><V><L><M><A><S><T><S><Y><L><P><S><Q><V><T><E><M><F><N><Q><G><R><A><F><A><T><V><R><L><P><F><C><G><H><K><N><I><C><S><L><A><T><I><Q><K><I><P><R><L><L><V><G><A><A><D><G><Y><L><Y><M><Y><N><L><D><P><Q><E><G><G><E><C><A><L><M><K><Q><H><R><L><D><G><S><L><E><T><T><N><E><I><L><D><S><A><S><H><D><C><P><L><V><T><Q><T><Y><G><A><A><A><G><K><G><T><Y><V><P><S><S><P><T><R><L><A><Y><T><D><D><L><G><A><V><G><G><A><C><L><E><D><E><A><S><A><L><R><L><D><E><D><S><E><H><P><P><M><I><L><R><T><D> | Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.<BOP> | Q9Y4P8 |
Q9H4S2 | GSX1_HUMAN | Homeobox protein GSH-1 | Homo | <M><P><R><S><F><L><V><D><S><L><V><L><R><E><A><G><E><K><K><A><P><E><G><S><P><P><P><L><F><P><Y><A><V><P><P><P><H><A><L><H><G><L><S><P><G><A><C><H><A><R><K><A><G><L><L><C><V><C><P><L><C><V><T><A><S><Q><L><H><G><P><P><G><P><P><A><L><P><L><L><K><A><S><F><P><P><F><G><S><Q><Y><C><H><A><P><L><G><R><Q><H><S><A><V><S><P><G><V><A><H><G><P><A><A><A><A><A><A><A><A><L><Y><Q><T><S><Y><P><L><P><D><P><R><Q><F><H><C><I><S><V><D><S><S><S><N><Q><L><P><S><S><K><R><M><R><T><A><F><T><S><T><Q><L><L><E><L><E><R><E><F><A><S><N><M><Y><L><S><R><L><R><R><I><E><I><A><T><Y><L><N><L><S><E><K><Q><V><K><I><W><F><Q><N><R><R><V><K><H><K><K><E><G><K><G><S><N><H><R><G><G><G><G><G><G><A><G><G><G><G><S><A><P><Q><G><C><K><C><A><S><L><S><S><A><K><C><S><E><D><D><D><E><L><P><M><S><P><S><S><S><G><K><D><D><R><D><L><T><V><T><P> | Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.<BOP> | Q9H4S2 |
A0A075B6T7 | TVA6_HUMAN | T cell receptor alpha variable 6 | Homo | <M><A><F><W><L><R><S><L><G><L><H><F><R><P><H><L><G><R><R><M><E><S><F><L><G><G><V><L><L><I><L><W><L><Q><V><D><W><V><K><S><Q><K><I><E><Q><N><S><E><A><L><N><I><Q><E><G><K><T><A><T><L><T><C><N><Y><T><N><Y><S><P><A><Y><L><Q><W><Y><R><Q><D><P><G><R><G><P><V><F><L><L><L><I><R><E><N><E><K><E><K><R><K><E><R><L><K><V><T><F><D><T><T><L><K><Q><S><L><F><H><I><T><A><S><Q><P><A><D><S><A><T><Y><L><C><A><L><D> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A075B6T7 |
P61966 | AP1S1_HUMAN | Sigma1A-adaptin | Homo | <M><M><R><F><M><L><L><F><S><R><Q><G><K><L><R><L><Q><K><W><Y><L><A><T><S><D><K><E><R><K><K><M><V><R><E><L><M><Q><V><V><L><A><R><K><P><K><M><C><S><F><L><E><W><R><D><L><K><V><V><Y><K><R><Y><A><S><L><Y><F><C><C><A><I><E><G><Q><D><N><E><L><I><T><L><E><L><I><H><R><Y><V><E><L><L><D><K><Y><F><G><S><V><C><E><L><D><I><I><F><N><F><E><K><A><Y><F><I><L><D><E><F><L><M><G><G><D><V><Q><D><T><S><K><K><S><V><L><K><A><I><E><Q><A><D><L><L><Q><E><E><D><E><S><P><R><S><V><L><E><E><M><G><L><A> | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.<BOP> | P61966 |
Q96AX1 | VP33A_HUMAN | Vacuolar protein sorting-associated protein 33A | Homo | <M><A><A><H><L><S><Y><G><R><V><N><L><N><V><L><R><E><A><V><R><R><E><L><R><E><F><L><D><K><C><A><G><S><K><A><I><V><W><D><E><Y><L><T><G><P><F><G><L><I><A><Q><Y><S><L><L><K><E><H><E><V><E><K><M><F><T><L><K><G><N><R><L><P><A><A><D><V><K><N><I><I><F><F><V><R><P><R><L><E><L><M><D><I><I><A><E><N><V><L><S><E><D><R><R><G><P><T><R><D><F><H><I><L><F><V><P><R><R><S><L><L><C><E><Q><R><L><K><D><L><G><V><L><G><S><F><I><H><R><E><E><Y><S><L><D><L><I><P><F><D><G><D><L><L><S><M><E><S><E><G><A><F><K><E><C><Y><L><E><G><D><Q><T><S><L><Y><H><A><A><K><G><L><M><T><L><Q><A><L><Y><G><T><I><P><Q><I><F><G><K><G><E><C><A><R><Q><V><A><N><M><M><I><R><M><K><R><E><F><T><G><S><Q><N><S><I><F><P><V><F><D><N><L><L><L><L><D><R><N><V><D><L><L><T><P><L><A><T><Q><L><T><Y><E><G><L><I><D><E><I><Y><G><I><Q><N><S><Y><V><K><L><P><P><E><K><F><A><P><K><K><Q><G><D><G><G><K><D><L><P><T><E><A><K><K><L><Q><L><N><S><A><E><E><L><Y><A><E><I><R><D><K><N><F><N><A><V><G><S><V><L><S><K><K><A><K><I><I><S><A><A><F><E><E><R><H><N><A><K><T><V><G><E><I><K><Q><F><V><S><Q><L><P><H><M><Q><A><A><R><G><S><L><A><N><H><T><S><I><A><E><L><I><K><D><V><T><T><S><E><D><F><F><D><K><L><T><V><E><Q><E><F><M><S><G><I><D><T><D><K><V><N><N><Y><I><E><D><C><I><A><Q><K><H><S><L><I><K><V><L><R><L><V><C><L><Q><S><V><C><N><S><G><L><K><Q><K><V><L><D><Y><Y><K><R><E><I><L><Q><T><Y><G><Y><E><H><I><L><T><L><H><N><L><E><K><A><G><L><L><K><P><Q><T><G><G><R><N><N><Y><P><T><I><R><K><T><L><R><L><W><M><D><D><V><N><E><Q><N><P><T><D><I><S><Y><V><Y><S><G><Y><A><P><L><S><V><R><L><A><Q><L><L><S><R><P><G><W><R><S><I><E><E><V><L><R><I><L><P><G><P><H><F><E><E><R><Q><P><L><P><T><G><L><Q><K><K><R><Q><P><G><E><N><R><V><T><L><I><F><F><L><G><G><V><T><F><A><E><I><A><A><L><R><F><L><S><Q><L><E><D><G><G><T><E><Y><V><I><A><T><T><K><L><M><N><G><T><S><W><I><E><A><L><M><E><K><P><F> | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 . The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG .<BOP> | Q96AX1 |
O94929 | ABLM3_HUMAN | Actin-binding LIM protein family member 3 | Homo | <M><N><T><S><I><P><Y><Q><Q><N><P><Y><N><P><R><G><S><S><N><V><I><Q><C><Y><R><C><G><D><T><C><K><G><E><V><V><R><V><H><N><N><H><F><H><I><R><C><F><T><C><Q><V><C><G><C><G><L><A><Q><S><G><F><F><F><K><N><Q><E><Y><I><C><T><Q><D><Y><Q><Q><L><Y><G><T><R><C><D><S><C><R><D><F><I><T><G><E><V><I><S><A><L><G><R><T><Y><H><P><K><C><F><V><C><S><L><C><R><K><P><F><P><I><G><D><K><V><T><F><S><G><K><E><C><V><C><Q><T><C><S><Q><S><M><A><S><S><K><P><I><K><I><R><G><P><S><H><C><A><G><C><K><E><E><I><K><H><G><Q><S><L><L><A><L><D><K><Q><W><H><V><S><C><F><K><C><Q><T><C><S><V><I><L><T><G><E><Y><I><S><K><D><G><V><P><Y><C><E><S><D><Y><H><A><Q><F><G><I><K><C><E><T><C><D><R><Y><I><S><G><R><V><L><E><A><G><G><K><H><Y><H><P><T><C><A><R><C><V><R><C><H><Q><M><F><T><E><G><E><E><M><Y><L><T><G><S><E><V><W><H><P><I><C><K><Q><A><A><R><A><E><K><K><L><K><H><R><R><T><S><E><T><S><I><S><P><P><G><S><S><I><G><S><P><N><R><V><I><C><A><K><V><D><N><E><I><L><N><Y><K><D><L><A><A><L><P><K><V><K><S><I><Y><E><V><Q><R><P><D><L><I><S><Y><E><P><H><S><R><Y><M><S><D><E><M><L><E><R><C><G><Y><G><E><S><L><G><T><L><S><P><Y><S><Q><D><I><Y><E><N><L><D><L><R><Q><R><R><A><S><S><P><G><Y><I><D><S><P><T><Y><S><R><Q><G><M><S><P><T><F><S><R><S><P><H><H><Y><Y><R><S><G><P><E><S><G><R><S><S><P><Y><H><S><Q><L><D><V><R><S><S><T><P><T><S><Y><Q><A><P><K><H><F><H><I><P><A><G><D><S><N><I><Y><R><K><P><P><I><Y><K><R><H><G><D><L><S><T><A><T><K><S><K><T><S><E><D><I><S><Q><T><S><K><Y><S><P><I><Y><S><P><D><P><Y><Y><A><S><E><S><E><Y><W><T><Y><H><G><S><P><K><V><P><R><A><R><R><F><S><S><G><G><E><E><D><D><F><D><R><S><M><H><K><L><Q><S><G><I><G><R><L><I><L><K><E><E><M><K><A><R><S><S><S><Y><A><D><P><W><T><P><P><R><S><S><T><S><S><R><E><A><L><H><T><A><G><Y><E><M><S><L><N><G><S><P><R><S><H><Y><L><A><D><S><D><P><L><I><S><K><S><A><S><L><P><A><Y><R><R><N><G><L><H><R><T><P><S><A><D><L><F><H><Y><D><S><M><N><A><V><N><W><G><M><R><E><Y><K><I><Y><P><Y><E><L><L><L><V><T><T><R><G><R><N><R><L><P><K><D><V><D><R><T><R><L><E><R><H><L><S><Q><E><E><F><Y><Q><V><F><G><M><T><I><S><E><F><D><R><L><A><L><W><K><R><N><E><L><K><K><Q><A><R><L><F> | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.<BOP> | O94929 |
Q96GZ6 | S41A3_HUMAN | Solute carrier family 41 member 3 | Homo | <M><D><G><T><E><T><R><Q><R><R><L><D><S><C><G><K><P><G><E><L><G><L><P><H><P><L><S><T><G><G><L><P><V><A><S><E><D><G><A><L><R><A><P><E><S><Q><S><V><T><P><K><P><L><E><T><E><P><S><R><E><T><T><W><S><I><G><L><Q><V><T><V><P><F><M><F><A><G><L><G><L><S><W><A><G><M><L><L><D><Y><F><Q><H><W><P><V><F><V><E><V><K><D><L><L><T><L><V><P><P><L><V><G><L><K><G><N><L><E><M><T><L><A><S><R><L><S><T><A><A><N><T><G><Q><I><D><D><P><Q><E><Q><H><R><V><I><S><S><N><L><A><L><I><Q><V><Q><A><T><V><V><G><L><L><A><A><V><A><A><L><L><L><G><V><V><S><R><E><E><V><D><V><A><K><V><E><L><L><C><A><S><S><V><L><T><A><F><L><A><A><F><A><L><G><V><L><M><V><C><I><V><I><G><A><R><K><L><G><V><N><P><D><N><I><A><T><P><I><A><A><S><L><G><D><L><I><T><L><S><I><L><A><L><V><S><S><F><F><Y><R><H><K><D><S><R><Y><L><T><P><L><V><C><L><S><F><A><A><L><T><P><V><W><V><L><I><A><K><Q><S><P><P><I><V><K><I><L><K><F><G><W><F><P><I><I><L><A><M><V><I><S><S><F><G><G><L><I><L><S><K><T><V><S><K><Q><Q><Y><K><G><M><A><I><F><T><P><V><I><C><G><V><G><G><N><L><V><A><I><Q><T><S><R><I><S><T><Y><L><H><M><W><S><A><P><G><V><L><P><L><Q><M><K><K><F><W><P><N><P><C><S><T><F><C><T><S><E><I><N><S><M><S><A><R><V><L><L><L><L><V><V><P><G><H><L><I><F><F><Y><I><I><Y><L><V><E><G><Q><S><V><I><N><S><Q><T><F><V><V><L><Y><L><L><A><G><L><I><Q><V><T><I><L><L><Y><L><A><E><V><M><V><R><L><T><W><H><Q><A><L><D><P><D><N><H><C><I><P><Y><L><T><G><L><G><D><L><L><G><S><S><S><V><G><H><T><A><A><V><P><R><R><C><T><A><S><P><G><W><G><L><I><Q><P><F><I><C><T><Q><H><L><I><V><S><L><L><S><F><Y><F><P><F><C><L><L><A><K><T><S><I> | Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane.<BOP> | Q96GZ6 |
O43583 | DENR_HUMAN | Smooth muscle cell-associated protein 3 | Homo | <M><A><A><D><I><S><E><S><S><G><A><D><C><K><G><D><P><R><N><S><A><K><L><D><A><D><Y><P><L><R><V><L><Y><C><G><V><C><S><L><P><T><E><Y><C><E><Y><M><P><D><V><A><K><C><R><Q><W><L><E><K><N><F><P><N><E><F><A><K><L><T><V><E><N><S><P><K><Q><E><A><G><I><S><E><G><Q><G><T><A><G><E><E><E><E><K><K><K><Q><K><R><G><G><R><G><Q><I><K><Q><K><K><K><T><V><P><Q><K><V><T><I><A><K><I><P><R><A><K><K><K><Y><V><T><R><V><C><G><L><A><T><F><E><I><D><L><K><E><A><Q><R><F><F><A><Q><K><F><S><C><G><A><S><V><T><G><E><D><E><I><I><I><Q><G><D><F><T><D><D><I><I><D><V><I><Q><E><K><W><P><E><V><D><D><D><S><I><E><D><L><G><E><V><K><K> | May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.<BOP> | O43583 |
Q86VY4 | TSYL5_HUMAN | Testis-specific Y-encoded-like protein 5 | Homo | <M><S><G><R><S><R><G><R><K><S><S><R><A><K><N><R><G><K><G><R><A><K><A><R><V><R><P><A><P><D><D><A><P><R><D><P><D><P><S><Q><Y><Q><S><L><G><E><D><T><Q><A><A><Q><V><Q><A><G><A><G><W><G><G><L><E><A><A><A><S><A><Q><L><L><R><L><G><E><E><A><A><C><R><L><P><L><D><C><G><L><A><L><R><A><R><A><A><G><D><H><G><Q><A><A><A><R><P><G><P><G><K><A><A><S><L><S><E><R><L><A><A><D><T><V><F><V><G><T><A><G><T><V><G><R><P><K><N><A><P><R><V><G><N><R><R><G><P><A><G><K><K><A><P><E><T><C><S><T><A><G><R><G><P><Q><V><I><A><G><G><R><Q><K><K><G><A><A><G><E><N><T><S><V><S><A><G><E><E><K><K><E><E><R><D><A><G><S><G><P><P><A><T><E><G><S><M><D><T><L><E><N><V><Q><L><K><L><E><N><M><N><A><Q><A><D><R><A><Y><L><R><L><S><R><K><F><G><Q><L><R><L><Q><H><L><E><R><R><N><H><L><I><Q><N><I><P><G><F><W><G><Q><A><F><Q><N><H><P><Q><L><A><S><F><L><N><S><Q><E><K><E><V><L><S><Y><L><N><S><L><E><V><E><E><L><G><L><A><R><L><G><Y><K><I><K><F><Y><F><D><R><N><P><Y><F><Q><N><K><V><L><I><K><E><Y><G><C><G><P><S><G><Q><V><V><S><R><S><T><P><I><Q><W><L><P><G><H><D><L><Q><S><L><S><Q><G><N><P><E><N><N><R><S><F><F><G><W><F><S><N><H><S><S><I><E><S><D><K><I><V><E><I><I><N><E><E><L><W><P><N><P><L><Q><F><Y><L><L><S><E><G><A><R><V><E><K><G><K><E><K><E><G><R><Q><G><P><G><K><Q><P><M><E><T><T><Q><P><G><V><S><Q><S><N> | Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.<BOP> | Q86VY4 |
P0C5Y9 | H2AB1_HUMAN | H2A Barr body-deficient | Homo | <M><P><R><R><R><R><R><R><G><S><S><G><A><G><G><R><G><R><T><C><S><R><T><V><R><A><E><L><S><F><S><V><S><Q><V><E><R><S><L><R><E><G><H><Y><A><Q><R><L><S><R><T><A><P><V><Y><L><A><A><V><I><E><Y><L><T><A><K><V><P><E><L><A><G><N><E><A><Q><N><S><G><E><R><N><I><T><P><L><L><L><D><M><V><V><H><N><D><R><L><L><S><T><L><F><N><T><T><T><I><S><Q><V><A><P><G><E><D> | Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability . Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo . They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase . They associate with spliceosome components and are required for mRNA splicing .<BOP> | P0C5Y9 |
P63126 | GAK9_HUMAN | HERV-K_6q14.1 provirus ancestral Gag polyprotein | Homo | <M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><I><S><V><S><D><A><P><G><S><G><I><I><D><C><N><E><K><T><R><K><K><S><Q><K><E><T><E><S><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><V><G><P><S><E><S><K><P><R><G><T><S><P><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><R><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><Q><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><I><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><I><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><G><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><P><P><Q><V><A><V><Q><Q> | The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP> | P63126 |
Q9H4H8 | FA83D_HUMAN | Spindle protein CHICA | Homo | <M><A><L><L><S><E><G><L><D><E><V><P><A><A><C><L><S><P><C><G><P><P><N><P><T><E><L><F><S><E><S><R><R><L><A><L><E><E><L><V><A><G><G><P><E><A><F><A><A><F><L><R><R><E><R><L><A><R><F><L><N><P><D><E><V><H><A><I><L><R><A><A><E><R><P><G><E><E><G><A><A><A><A><A><A><A><E><D><S><F><G><S><S><H><D><C><S><S><G><T><Y><F><P><E><Q><S><D><L><E><P><P><L><L><E><L><G><W><P><A><F><Y><Q><G><A><Y><R><G><A><T><R><V><E><T><H><F><Q><P><R><G><A><G><E><G><G><P><Y><G><C><K><D><A><L><R><Q><Q><L><R><S><A><R><E><V><I><A><V><V><M><D><V><F><T><D><I><D><I><F><R><D><L><Q><E><I><C><R><K><Q><G><V><A><V><Y><I><L><L><D><Q><A><L><L><S><Q><F><L><D><M><C><M><D><L><K><V><H><P><E><Q><E><K><L><M><T><V><R><T><I><T><G><N><I><Y><Y><A><R><S><G><T><K><I><I><G><K><V><H><E><K><F><T><L><I><D><G><I><R><V><A><T><G><S><Y><S><F><T><W><T><D><G><K><L><N><S><S><N><L><V><I><L><S><G><Q><V><V><E><H><F><D><L><E><F><R><I><L><Y><A><Q><S><K><P><I><S><P><K><L><L><S><H><F><Q><S><S><N><K><F><D><H><L><T><N><R><K><P><Q><S><K><E><L><T><L><G><N><L><L><R><M><R><L><A><R><L><S><S><T><P><R><K><A><D><L><D><P><E><M><P><A><E><G><K><A><E><R><K><P><H><D><C><E><S><S><T><V><S><E><E><D><Y><F><S><S><H><R><D><E><L><Q><S><R><K><A><I><D><A><A><T><Q><T><E><P><G><E><E><M><P><G><L><S><V><S><E><V><G><T><Q><T><S><I><T><T><A><C><A><G><T><Q><T><A><V><I><T><R><I><A><S><S><Q><T><T><I><W><S><R><S><T><T><T><Q><T><D><M><D><E><N><I><L><F><P><R><G><T><Q><S><T><E><G><S><P><V><S><K><M><S><V><S><R><S><S><S><L><K><S><S><S><S><V><S><S><Q><G><S><V><A><S><S><T><G><S><P><A><S><I><R><T><T><D><F><H><N><P><G><Y><P><K><Y><L><G><T><P><H><L><E><L><Y><L><S><D><S><L><R><N><L><N><K><E><R><Q><F><H><F><A><G><I><R><S><R><L><N><H><M><L><A><M><L><S><R><R><T><L><F><T><E><N><H><L><G><L><H><S><G><N><F><S><R><V><N><L><L><A><V><R><D><V><A><L><Y><P><S><Y><Q> | Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC . May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade . May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 .<BOP> | Q9H4H8 |
Q96HJ5 | MS4A3_HUMAN | Hematopoietic-specific transmembrane protein 4 | Homo | <M><A><S><H><E><V><D><N><A><E><L><G><S><A><S><A><H><G><T><P><G><S><E><A><G><P><E><E><L><N><T><S><V><Y><Q><P><I><D><G><S><P><D><Y><Q><K><A><K><L><Q><V><L><G><A><I><Q><I><L><N><A><A><M><I><L><A><L><G><V><F><L><G><S><L><Q><Y><P><Y><H><F><Q><K><H><F><F><F><F><T><F><Y><T><G><Y><P><I><W><G><A><V><F><F><C><S><S><G><T><L><S><V><V><A><G><I><K><P><T><R><T><W><I><Q><N><S><F><G><M><N><I><A><S><A><T><I><A><L><V><G><T><A><F><L><S><L><N><I><A><V><N><I><Q><S><L><R><S><C><H><S><S><S><E><S><P><D><L><C><N><Y><M><G><S><I><S><N><G><M><V><S><L><L><L><I><L><T><L><L><E><L><C><V><T><I><S><T><I><A><M><W><C><N><A><N><C><C><N><S><R><E><E><I><S><S><P><P><N><S><V> | Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).<BOP> | Q96HJ5 |
Q9UKI8 | TLK1_HUMAN | Tousled-like kinase 1 | Homo | <M><S><V><Q><S><S><S><G><S><L><E><G><P><P><S><W><S><Q><L><S><T><S><P><T><P><G><S><A><A><A><A><R><S><L><L><N><H><T><P><P><S><G><R><P><R><E><G><A><M><D><E><L><H><S><L><D><P><R><R><Q><E><L><L><E><A><R><F><T><G><V><A><S><G><S><T><G><S><T><G><S><C><S><V><G><A><K><A><S><T><N><N><E><S><S><N><H><S><F><G><S><L><G><S><L><S><D><K><E><S><E><T><P><E><K><K><Q><S><E><S><S><R><G><R><K><R><K><A><E><N><Q><N><E><S><S><Q><G><K><S><I><G><G><R><G><H><K><I><S><D><Y><F><E><Y><Q><G><G><N><G><S><S><P><V><R><G><I><P><P><A><I><R><S><P><Q><N><S><H><S><H><S><T><P><S><S><S><V><R><P><N><S><P><S><P><T><A><L><A><F><G><D><H><P><I><V><Q><P><K><Q><L><S><F><K><I><I><Q><T><D><L><T><M><L><K><L><A><A><L><E><S><N><K><I><Q><D><L><E><K><K><E><G><R><I><D><D><L><L><R><A><N><C><D><L><R><R><Q><I><D><E><Q><Q><K><L><L><E><K><Y><K><E><R><L><N><K><C><I><S><M><S><K><K><L><L><I><E><K><S><T><Q><E><K><L><S><S><R><E><K><S><M><Q><D><R><L><R><L><G><H><F><T><T><V><R><H><G><A><S><F><T><E><Q><W><T><D><G><F><A><F><Q><N><L><V><K><Q><Q><E><W><V><N><Q><Q><R><E><D><I><E><R><Q><R><K><L><L><A><K><R><K><P><P><T><A><N><N><S><Q><A><P><S><T><N><S><E><P><K><Q><R><K><N><K><A><V><N><G><A><E><N><D><P><F><V><R><P><N><L><P><Q><L><L><T><L><A><E><Y><H><E><Q><E><E><I><F><K><L><R><L><G><H><L><K><K><E><E><A><E><I><Q><A><E><L><E><R><L><E><R><V><R><N><L><H><I><R><E><L><K><R><I><N><N><E><D><N><S><Q><F><K><D><H><P><T><L><N><E><R><Y><L><L><L><H><L><L><G><R><G><G><F><S><E><V><Y><K><A><F><D><L><Y><E><Q><R><Y><A><A><V><K><I><H><Q><L><N><K><S><W><R><D><E><K><K><E><N><Y><H><K><H><A><C><R><E><Y><R><I><H><K><E><L><D><H><P><R><I><V><K><L><Y><D><Y><F><S><L><D><T><D><T><F><C><T><V><L><E><Y><C><E><G><N><D><L><D><F><Y><L><K><Q><H><K><L><M><S><E><K><E><A><R><S><I><V><M><Q><I><V><N><A><L><R><Y><L><N><E><I><K><P><P><I><I><H><Y><D><L><K><P><G><N><I><L><L><V><D><G><T><A><C><G><E><I><K><I><T><D><F><G><L><S><K><I><M><D><D><D><S><Y><G><V><D><G><M><D><L><T><S><Q><G><A><G><T><Y><W><Y><L><P><P><E><C><F><V><V><G><K><E><P><P><K><I><S><N><K><V><D><V><W><S><V><G><V><I><F><F><Q><C><L><Y><G><R><K><P><F><G><H><N><Q><S><Q><Q><D><I><L><Q><E><N><T><I><L><K><A><T><E><V><Q><F><P><V><K><P><V><V><S><S><E><A><K><A><F><I><R><R><C><L><A><Y><R><K><E><D><R><F><D><V><H><Q><L><A><N><D><P><Y><L><L><P><H><M><R><R><S><N><S><S><G><N><L><H><M><A><G><L><T><A><S><P><T><P><P><S><S><S><I><I><T><Y> | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.<BOP> | Q9UKI8 |
P25791 | RBTN2_HUMAN | T-cell translocation protein 2 | Homo | <M><S><S><A><I><E><R><K><S><L><D><P><S><E><E><P><V><D><E><V><L><Q><I><P><P><S><L><L><T><C><G><G><C><Q><Q><N><I><G><D><R><Y><F><L><K><A><I><D><Q><Y><W><H><E><D><C><L><S><C><D><L><C><G><C><R><L><G><E><V><G><R><R><L><Y><Y><K><L><G><R><K><L><C><R><R><D><Y><L><R><L><F><G><Q><D><G><L><C><A><S><C><D><K><R><I><R><A><Y><E><M><T><M><R><V><K><D><K><V><Y><H><L><E><C><F><K><C><A><A><C><Q><K><H><F><C><V><G><D><R><Y><L><L><I><N><S><D><I><V><C><E><Q><D><I><Y><E><W><T><K><I><N><G><M><I> | Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.<BOP> | P25791 |
Q7Z3H0 | PANKY_HUMAN | Ankyrin repeat domain-containing protein 33 | Homo | <M><K><V><Q><P><S><V><T><C><V><A><S><W><G><G><I><V><H><L><E><A><F><G><D><P><V><I><V><L><R><G><A><W><A><V><P><R><V><D><C><L><I><D><T><L><R><T><P><N><A><S><C><M><R><K><G><T><H><L><L><V><P><C><L><E><E><E><E><L><A><L><H><R><R><R><L><D><M><S><E><A><L><P><C><P><G><K><E><T><P><T><P><G><C><R><L><G><A><L><Y><W><A><C><V><H><N><D><P><T><Q><L><Q><A><I><L><D><G><G><V><S><P><E><E><A><T><Q><V><D><S><N><G><R><T><G><L><M><V><A><C><Y><H><G><F><Q><S><V><V><A><L><L><S><H><C><P><F><L><D><V><N><Q><Q><D><K><G><G><D><T><A><L><M><L><A><A><Q><A><G><H><V><P><L><V><S><L><L><L><N><Y><Y><V><G><L><D><L><E><R><R><D><Q><R><G><L><T><A><L><M><K><A><A><M><R><N><R><C><A><D><L><T><A><V><D><P><V><R><G><K><T><A><L><E><W><A><V><L><T><D><S><F><D><T><V><W><R><I><R><Q><L><L><R><R><P><Q><V><E><Q><L><S><Q><H><Y><K><P><E><W><P><A><L><S><G><L><V><A><Q><A><Q><A><Q><A><Q><V><A><P><S><L><L><E><R><L><Q><A><T><L><S><L><P><F><A><P><S><P><Q><E><G><G><V><L><D><H><L><V><T><A><T><T><S><L><A><S><P><F><V><T><T><A><C><H><T><L><C><P><D><H><P><P><S><L><G><T><R><S><K><S><V><P><E><L><L><G><T><A><P><P><P><P><L><V><P><Q><S><P><P><G><S><P><Q><R><S><P><W><V><F><V><P><Y><Q><S><P><Q><G><I><L><S><K><C><L><Q><W><L><Q><P><R><D><S><T><S><P><R><P><Q><V><P><K><I><L><L><S><K><A><S><S><S><S><H><Q><C><Q><P><K><P><S><P><S><G><H><Q><S><L><A><L><P><L><W><R><Y><Q><E><L><R><I><E><K><R><K><Q><E><E><E><A><R><M><A><Q><K> | Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.<BOP> | Q7Z3H0 |
A6NM28 | ZFP92_HUMAN | Zinc finger protein 92 homolog | Homo | <M><A><A><I><L><L><T><T><R><P><K><V><P><V><S><F><E><D><V><S><V><Y><F><T><K><T><E><W><K><L><L><D><L><R><Q><K><V><L><Y><K><R><V><M><L><E><N><Y><S><H><L><V><S><L><G><F><S><F><S><K><P><H><L><I><S><Q><L><E><R><G><E><G><P><W><V><A><D><I><P><R><T><W><A><T><A><G><L><H><I><G><D><R><T><Q><S><K><T><S><T><S><T><Q><K><H><S><G><R><Q><L><P><G><A><D><P><Q><G><G><K><E><G><Q><A><A><R><S><S><V><L><Q><R><G><A><Q><G><L><G><Q><S><S><A><A><G><P><Q><G><P><K><G><A><E><K><R><Y><L><C><Q><Q><C><G><K><A><F><S><R><S><S><N><L><I><K><H><R><I><I><H><S><G><E><K><P><Y><A><C><P><E><C><G><K><L><F><R><R><S><F><A><L><L><E><H><Q><R><I><H><S><G><E><K><P><Y><A><C><P><E><C><S><K><T><F><T><R><S><S><N><L><I><K><H><Q><V><I><H><S><G><E><R><P><F><A><C><G><D><C><G><K><L><F><R><R><S><F><A><L><L><E><H><A><R><V><H><S><G><E><R><P><Y><A><C><P><E><C><G><K><A><F><S><R><S><S><N><L><I><E><H><Q><R><T><H><R><G><E><K><P><Y><A><C><G><Q><C><A><K><A><F><K><G><V><S><Q><L><I><H><H><Q><R><S><H><S><G><E><R><P><F><A><C><R><E><C><G><K><A><F><R><G><R><S><G><L><S><Q><H><R><R><V><H><S><G><E><K><P><Y><E><C><S><D><C><G><K><A><F><G><R><R><A><N><L><F><K><H><Q><A><V><H><G><A><R><R><P><A><K><A><E><T><A><R><R><L><A><G><P><G><S><T><G><P><G><S><A><V><A><A><T><S><P><P><R><P><S><T><A><A><R><P><S><R><P><S><R><R> | May be involved in transcriptional regulation.<BOP> | A6NM28 |
Q01892 | SPIB_HUMAN | Transcription factor Spi-B | Homo | <M><L><A><L><E><A><A><Q><L><D><G><P><H><F><S><C><L><Y><P><D><G><V><F><Y><D><L><D><S><C><K><H><S><S><Y><P><D><S><E><G><A><P><D><S><L><W><D><W><T><V><A><P><P><V><P><A><T><P><Y><E><A><F><D><P><A><A><A><A><F><S><H><P><Q><A><A><Q><L><C><Y><E><P><P><T><Y><S><P><A><G><N><L><E><L><A><P><S><L><E><A><P><G><P><G><L><P><A><Y><P><T><E><N><F><A><S><Q><T><L><V><P><P><A><Y><A><P><Y><P><S><P><V><L><S><E><E><E><D><L><P><L><D><S><P><A><L><E><V><S><D><S><E><S><D><E><A><L><V><A><G><P><E><G><K><G><S><E><A><G><T><R><K><K><L><R><L><Y><Q><F><L><L><G><L><L><T><R><G><D><M><R><E><C><V><W><W><V><E><P><G><A><G><V><F><Q><F><S><S><K><H><K><E><L><L><A><R><R><W><G><Q><Q><K><G><N><R><K><R><M><T><Y><Q><K><L><A><R><A><L><R><N><Y><A><K><T><G><E><I><R><K><V><K><R><K><L><T><Y><Q><F><D><S><A><L><L><P><A><V><R><R><A> | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.<BOP> | Q01892 |
Q9UDX5 | MTFP1_HUMAN | Mitochondrial 18 kDa protein | Homo | <M><S><E><P><Q><P><R><G><A><E><R><D><L><Y><R><D><T><W><V><R><Y><L><G><Y><A><N><E><V><G><E><A><F><R><S><L><V><P><A><A><V><V><W><L><S><Y><G><V><A><S><S><Y><V><L><A><D><A><I><D><K><G><K><K><A><G><E><V><P><S><P><E><A><G><R><S><A><R><V><T><V><A><V><V><D><T><F><V><W><Q><A><L><A><S><V><A><I><P><G><F><T><I><N><R><V><C><A><A><S><L><Y><V><L><G><T><A><T><R><W><P><L><A><V><R><K><W><T><T><T><A><L><G><L><L><T><I><P><I><I><I><H><P><I><D><R><S><V><D><F><L><L><D><S><S><L><R><K><L><Y><P><T><V><G><K><P><S><S><S> | Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.<BOP> | Q9UDX5 |
O60656 | UD19_HUMAN | lugP4 | Homo | <M><A><C><T><G><W><T><S><P><L><P><L><C><V><C><L><L><L><T><C><G><F><A><E><A><G><K><L><L><V><V><P><M><D><G><S><H><W><F><T><M><R><S><V><V><E><K><L><I><L><R><G><H><E><V><V><V><V><M><P><E><V><S><W><Q><L><G><R><S><L><N><C><T><V><K><T><Y><S><T><S><Y><T><L><E><D><L><D><R><E><F><K><A><F><A><H><A><Q><W><K><A><Q><V><R><S><I><Y><S><L><L><M><G><S><Y><N><D><I><F><D><L><F><F><S><N><C><R><S><L><F><K><D><K><K><L><V><E><Y><L><K><E><S><S><F><D><A><V><F><L><D><P><F><D><N><C><G><L><I><V><A><K><Y><F><S><L><P><S><V><V><F><A><R><G><I><L><C><H><Y><L><E><E><G><A><Q><C><P><A><P><L><S><Y><V><P><R><I><L><L><G><F><S><D><A><M><T><F><K><E><R><V><R><N><H><I><M><H><L><E><E><H><L><L><C><H><R><F><F><K><N><A><L><E><I><A><S><E><I><L><Q><T><P><V><T><E><Y><D><L><Y><S><H><T><S><I><W><L><L><R><T><D><F><V><L><D><Y><P><K><P><V><M><P><N><M><I><F><I><G><G><I><N><C><H><Q><G><K><P><L><P><M><E><F><E><A><Y><I><N><A><S><G><E><H><G><I><V><V><F><S><L><G><S><M><V><S><E><I><P><E><K><K><A><M><A><I><A><D><A><L><G><K><I><P><Q><T><V><L><W><R><Y><T><G><T><R><P><S><N><L><A><N><N><T><I><L><V><K><W><L><P><Q><N><D><L><L><G><H><P><M><T><R><A><F><I><T><H><A><G><S><H><G><V><Y><E><S><I><C><N><G><V><P><M><V><M><M><P><L><F><G><D><Q><M><D><N><A><K><R><M><E><T><K><G><A><G><V><T><L><N><V><L><E><M><T><S><E><D><L><E><N><A><L><K><A><V><I><N><D><K><S><Y><K><E><N><I><M><R><L><S><S><L><H><K><D><R><P><V><E><P><L><D><L><A><V><F><W><V><E><F><V><M><R><H><K><G><A><P><H><L><R><P><A><A><H><D><L><T><W><Y><Q><Y><H><S><L><D><V><I><G><F><L><L><A><V><V><L><T><V><A><F><I><T><F><K><C><C><A><Y><G><Y><R><K><C><L><G><K><K><G><R><V><K><K><A><H><K><S><K><T><H> | Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.<BOP> | O60656 |
O60779 | S19A2_HUMAN | Thiamine carrier 1 | Homo | <M><D><V><P><G><P><V><S><R><R><A><A><A><A><A><A><T><V><L><L><R><T><A><R><V><R><R><E><C><W><F><L><P><T><A><L><L><C><A><Y><G><F><F><A><S><L><R><P><S><E><P><F><L><T><P><Y><L><L><G><P><D><K><N><L><T><E><R><E><V><F><N><E><I><Y><P><V><W><T><Y><S><Y><L><V><L><L><F><P><V><F><L><A><T><D><Y><L><R><Y><K><P><V><V><L><L><Q><G><L><S><L><I><V><T><W><F><M><L><L><Y><A><Q><G><L><L><A><I><Q><F><L><E><F><F><Y><G><I><A><T><A><T><E><I><A><Y><Y><S><Y><I><Y><S><V><V><D><L><G><M><Y><Q><K><V><T><S><Y><C><R><S><A><T><L><V><G><F><T><V><G><S><V><L><G><Q><I><L><V><S><V><A><G><W><S><L><F><S><L><N><V><I><S><L><T><C><V><S><V><A><F><A><V><A><W><F><L><P><M><P><Q><K><S><L><F><F><H><H><I><P><S><T><C><Q><R><V><N><G><I><K><V><Q><N><G><G><I><V><T><D><T><P><A><S><N><H><L><P><G><W><E><D><I><E><S><K><I><P><L><N><M><E><E><P><P><V><E><E><P><E><P><K><P><D><R><L><L><V><L><K><V><L><W><N><D><F><L><M><C><Y><S><S><R><P><L><L><C><W><S><V><W><W><A><L><S><T><C><G><Y><F><Q><V><V><N><Y><T><Q><G><L><W><E><K><V><M><P><S><R><Y><A><A><I><Y><N><G><G><V><E><A><V><S><T><L><L><G><A><V><A><V><F><A><V><G><Y><I><K><I><S><W><S><T><W><G><E><M><T><L><S><L><F><S><L><L><I><A><A><A><V><Y><I><M><D><T><V><G><N><I><W><V><C><Y><A><S><Y><V><V><F><R><I><I><Y><M><L><L><I><T><I><A><T><F><Q><I><A><A><N><L><S><M><E><R><Y><A><L><V><F><G><V><N><T><F><I><A><L><A><L><Q><T><L><L><T><L><I><V><V><D><A><S><G><L><G><L><E><I><T><T><Q><F><L><I><Y><A><S><Y><F><A><L><I><A><V><V><F><L><A><S><G><A><V><S><V><M><K><K><C><R><K><L><E><D><P><Q><S><S><S><Q><V><T><T><S> | High-affinity transporter for the intake of thiamine.<BOP> | O60779 |
P78413 | IRX4_HUMAN | Iroquois homeobox protein 4 | Homo | <M><S><Y><P><Q><F><G><Y><P><Y><S><S><A><P><Q><F><L><M><A><T><N><S><L><S><T><C><C><E><S><G><G><R><T><L><A><D><S><G><P><A><A><S><A><Q><A><P><V><Y><C><P><V><Y><E><S><R><L><L><A><T><A><R><H><E><L><N><S><A><A><A><L><G><V><Y><G><G><P><Y><G><G><S><Q><G><Y><G><N><Y><V><T><Y><G><S><E><A><S><A><F><Y><S><L><N><S><F><D><S><K><D><G><S><G><S><A><H><G><G><L><A><P><A><A><A><A><Y><Y><P><Y><E><P><A><L><G><Q><Y><P><Y><D><R><Y><G><T><M><D><S><G><T><R><R><K><N><A><T><R><E><T><T><S><T><L><K><A><W><L><Q><E><H><R><K><N><P><Y><P><T><K><G><E><K><I><M><L><A><I><I><T><K><M><T><L><T><Q><V><S><T><W><F><A><N><A><R><R><R><L><K><K><E><N><K><M><T><W><P><P><R><N><K><C><A><D><E><K><R><P><Y><A><E><G><E><E><E><E><G><G><E><E><E><A><R><E><E><P><L><K><S><S><K><N><A><E><P><V><G><K><E><E><K><E><L><E><L><S><D><L><D><D><F><D><P><L><E><A><E><P><P><A><C><E><L><K><P><P><F><H><S><L><D><G><G><L><E><R><V><P><A><A><P><D><G><P><V><K><E><A><S><G><A><L><R><M><S><L><A><A><G><G><G><A><A><L><D><E><D><L><E><R><A><R><S><C><L><R><S><A><A><A><G><P><E><P><L><P><G><A><E><G><G><P><Q><V><C><E><A><K><L><G><F><V><P><A><G><A><S><A><G><L><E><A><K><P><R><I><W><S><L><A><H><T><A><T><A><A><A><A><A><A><T><S><L><S><Q><T><E><F><P><S><C><M><L><K><R><Q><G><P><A><A><P><A><A><V><S><S><A><P><A><T><S><P><S><V><A><L><P><H><S><G><A><L><D><R><H><Q><D><S><P><V><T><S><L><R><N><W><V><D><G><V><F><H><D><P><I><L><R><H><S><T><L><N><Q><A><W><A><T><A><K><G><A><L><L><D><P><G><P><L><G><R><S><L><G><A><G><A><N><V><L><T><A><P><L><A><R><A><F><P><P><A><V><P><Q><D><A><P><A><A><G><A><A><R><E><L><L><A><L><P><K><A><G><G><K><P><F><C><A> | Likely to be an important mediator of ventricular differentiation during cardiac development.<BOP> | P78413 |
O14907 | TX1B3_HUMAN | Tax-interacting protein 1 | Homo | <M><S><Y><I><P><G><Q><P><V><T><A><V><V><Q><R><V><E><I><H><K><L><R><Q><G><E><N><L><I><L><G><F><S><I><G><G><G><I><D><Q><D><P><S><Q><N><P><F><S><E><D><K><T><D><K><G><I><Y><V><T><R><V><S><E><G><G><P><A><E><I><A><G><L><Q><I><G><D><K><I><M><Q><V><N><G><W><D><M><T><M><V><T><H><D><Q><A><R><K><R><L><T><K><R><S><E><E><V><V><R><L><L><V><T><R><Q><S><L><Q><K><A><V><Q><Q><S><M><L><S> | May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.<BOP> | O14907 |
Q9HBH5 | RDH14_HUMAN | Short chain dehydrogenase/reductase family 7C member 4 | Homo | <M><A><V><A><T><A><A><A><V><L><A><A><L><G><G><A><L><W><L><A><A><R><R><F><V><G><P><R><V><Q><R><L><R><R><G><G><D><P><G><L><M><H><G><K><T><V><L><I><T><G><A><N><S><G><L><G><R><A><T><A><A><E><L><L><R><L><G><A><R><V><I><M><G><C><R><D><R><A><R><A><E><E><A><A><G><Q><L><R><R><E><L><R><Q><A><A><E><C><G><P><E><P><G><V><S><G><V><G><E><L><I><V><R><E><L><D><L><A><S><L><R><S><V><R><A><F><C><Q><E><M><L><Q><E><E><P><R><L><D><V><L><I><N><N><A><G><I><F><Q><C><P><Y><M><K><T><E><D><G><F><E><M><Q><F><G><V><N><H><L><G><H><F><L><L><T><N><L><L><L><G><L><L><K><S><S><A><P><S><R><I><V><V><V><S><S><K><L><Y><K><Y><G><D><I><N><F><D><D><L><N><S><E><Q><S><Y><N><K><S><F><C><Y><S><R><S><K><L><A><N><I><L><F><T><R><E><L><A><R><R><L><E><G><T><N><V><T><V><N><V><L><H><P><G><I><V><R><T><N><L><G><R><H><I><H><I><P><L><L><V><K><P><L><F><N><L><V><S><W><A><F><F><K><T><P><V><E><G><A><Q><T><S><I><Y><L><A><S><S><P><E><V><E><G><V><S><G><R><Y><F><G><D><C><K><E><E><E><L><L><P><K><A><M><D><E><S><V><A><R><K><L><W><D><I><S><E><V><M><V><G><L><L><K> | Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid.<BOP> | Q9HBH5 |
P41250 | GARS_HUMAN | Glycyl-tRNA synthetase 1 | Homo | <M><P><S><P><R><P><V><L><L><R><G><A><R><A><A><L><L><L><L><L><P><P><R><L><L><A><R><P><S><L><L><L><R><R><S><L><S><A><A><S><C><P><P><I><S><L><P><A><A><A><S><R><S><S><M><D><G><A><G><A><E><E><V><L><A><P><L><R><L><A><V><R><Q><Q><G><D><L><V><R><K><L><K><E><D><K><A><P><Q><V><D><V><D><K><A><V><A><E><L><K><A><R><K><R><V><L><E><A><K><E><L><A><L><Q><P><K><D><D><I><V><D><R><A><K><M><E><D><T><L><K><R><R><F><F><Y><D><Q><A><F><A><I><Y><G><G><V><S><G><L><Y><D><F><G><P><V><G><C><A><L><K><N><N><I><I><Q><T><W><R><Q><H><F><I><Q><E><E><Q><I><L><E><I><D><C><T><M><L><T><P><E><P><V><L><K><T><S><G><H><V><D><K><F><A><D><F><M><V><K><D><V><K><N><G><E><C><F><R><A><D><H><L><L><K><A><H><L><Q><K><L><M><S><D><K><K><C><S><V><E><K><K><S><E><M><E><S><V><L><A><Q><L><D><N><Y><G><Q><Q><E><L><A><D><L><F><V><N><Y><N><V><K><S><P><I><T><G><N><D><L><S><P><P><V><S><F><N><L><M><F><K><T><F><I><G><P><G><G><N><M><P><G><Y><L><R><P><E><T><A><Q><G><I><F><L><N><F><K><R><L><L><E><F><N><Q><G><K><L><P><F><A><A><A><Q><I><G><N><S><F><R><N><E><I><S><P><R><S><G><L><I><R><V><R><E><F><T><M><A><E><I><E><H><F><V><D><P><S><E><K><D><H><P><K><F><Q><N><V><A><D><L><H><L><Y><L><Y><S><A><K><A><Q><V><S><G><Q><S><A><R><K><M><R><L><G><D><A><V><E><Q><G><V><I><N><N><T><V><L><G><Y><F><I><G><R><I><Y><L><Y><L><T><K><V><G><I><S><P><D><K><L><R><F><R><Q><H><M><E><N><E><M><A><H><Y><A><C><D><C><W><D><A><E><S><K><T><S><Y><G><W><I><E><I><V><G><C><A><D><R><S><C><Y><D><L><S><C><H><A><R><A><T><K><V><P><L><V><A><E><K><P><L><K><E><P><K><T><V><N><V><V><Q><F><E><P><S><K><G><A><I><G><K><A><Y><K><K><D><A><K><L><V><M><E><Y><L><A><I><C><D><E><C><Y><I><T><E><M><E><M><L><L><N><E><K><G><E><F><T><I><E><T><E><G><K><T><F><Q><L><T><K><D><M><I><N><V><K><R><F><Q><K><T><L><Y><V><E><E><V><V><P><N><V><I><E><P><S><F><G><L><G><R><I><M><Y><T><V><F><E><H><T><F><H><V><R><E><G><D><E><Q><R><T><F><F><S><F><P><A><V><V><A><P><F><K><C><S><V><L><P><L><S><Q><N><Q><E><F><M><P><F><V><K><E><L><S><E><A><L><T><R><H><G><V><S><H><K><V><D><D><S><S><G><S><I><G><R><R><Y><A><R><T><D><E><I><G><V><A><F><G><V><T><I><D><F><D><T><V><N><K><T><P><H><T><A><T><L><R><D><R><D><S><M><R><Q><I><R><A><E><I><S><E><L><P><S><I><V><Q><D><L><A><N><G><N><I><T><W><A><D><V><E><A><R><Y><P><L><F><E><G><Q><E><T><G><K><K><E><T><I><E><E> | Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis .<BOP> | P41250 |
Q2M2Z5 | KIZ_HUMAN | Polo-like kinase 1 substrate 1 | Homo | <M><S><R><T><L><A><S><A><V><P><L><S><S><P><D><Y><Y><E><R><L><G><Q><L><Q><H><G><L><R><D><S><E><K><K><R><L><D><L><E><K><K><L><Y><E><Y><N><Q><S><D><T><C><R><V><K><L><K><Y><V><K><L><K><N><Y><L><K><E><I><C><E><S><E><K><K><A><H><T><R><N><Q><E><Y><L><K><R><F><E><R><V><Q><A><H><V><V><H><F><T><T><N><T><E><K><L><Q><K><L><K><L><E><Y><E><T><Q><I><K><K><M><L><C><S><K><D><S><L><G><L><K><E><E><L><T><D><E><D><R><E><K><V><A><V><H><E><G><I><N><S><G><T><A><M><S><R><G><L><Y><Q><P><A><T><I><F><M><G><R><Q><M><S><A><I><L><S><M><R><D><F><S><T><E><H><K><S><P><Q><P><T><K><N><F><S><I><P><D><P><H><S><H><R><Q><T><A><Q><S><S><N><V><T><D><S><C><V><V><Q><T><S><N><D><T><Q><C><L><N><K><S><D><N><I><D><G><K><A><S><L><Q><I><G><E><K><M><P><V><T><A><S><V><L><S><E><E><E><Q><T><H><C><L><E><I><G><S><N><T><R><H><G><K><S><N><L><S><E><G><K><K><S><A><E><L><N><S><P><L><R><E><R><L><S><P><E><N><R><T><T><D><L><K><C><D><S><S><S><G><S><E><G><E><I><L><T><R><E><H><I><E><V><E><E><K><R><A><S><P><P><V><S><P><I><P><V><S><E><Y><C><E><S><E><N><K><W><S><Q><E><K><H><S><P><W><E><G><V><S><D><H><L><A><H><R><E><P><K><S><Q><K><P><F><R><K><M><Q><E><E><E><E><E><S><W><S><T><S><S><D><L><T><I><S><I><S><E><D><D><L><I><L><E><S><P><E><P><Q><P><N><P><G><G><K><M><E><G><E><D><G><I><E><A><L><K><L><I><H><A><E><Q><E><R><V><A><L><S><T><E><K><N><C><I><L><Q><T><L><S><S><P><D><S><E><K><E><S><S><T><N><A><P><T><R><E><P><G><Q><T><P><D><S><D><V><P><R><A><Q><V><G><Q><H><V><A><T><L><K><E><H><D><N><S><V><K><E><E><A><T><A><L><L><R><K><A><L><T><E><E><C><G><R><R><S><A><I><H><S><S><E><S><S><C><S><L><P><S><I><L><N><D><N><S><G><I><K><E><A><K><P><A><V><W><L><N><S><V><P><T><R><E><Q><E><V><S><S><G><C><G><D><K><S><K><K><E><N><V><A><A><D><I><P><I><T><E><T><E><A><Y><Q><L><L><K><K><A><T><L><Q><D><N><T><N><Q><T><E><N><R><F><Q><K><T><D><A><S><V><S><H><L><S><G><L><N><I><G><S><G><A><F><E><T><K><T><A><N><K><I><A><S><E><A><S><F><S><S><S><E><G><S><P><L><S><R><H><E><N><K><K><K><P><V><I><N><L><K><S><N><A><L><W><D><E><S><D><D><S><N><S><E><I><E><A><A><L><R><P><R><N><H><N><T><D><D><S><D><D><F><Y><D> | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.<BOP> | Q2M2Z5 |
B2CW77 | KILIN_HUMAN | Killin | Homo | <M><D><R><P><G><P><G><S><A><R><P><G><R><T><V><H><V><W><G><Y><R><V><E><W><K><V><R><N><G><R><K><L><Q><P><S><E><W><A><G><R><G><D><L><G><G><F><K><R><R><W><K><D><T><R><A><T><V><G><T><T><F><R><R><R><S><R><V><S><L><V><G><E><L><S><K><F><P><L><P><S><D><S><S><G><G><K><S><S><S><S><F><A><R><G><A><L><A><W><C><R><Q><R><N><P><N><P><S><C><A><A><A><E><T><G><A><R><T><S><L><P><K><E><R><C><R><G><W><R><L><G><N><W><L><H><K><H><P><H><P><N><T><C><P><R><L><P><A><C><W><L><P><P><I><L><T><E><R><G><E><R><V><P><K><L><V><P><L><L><A><C><Y><P><K><S><K><P><K><D> | DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.<BOP> | B2CW77 |
Q9NYY3 | PLK2_HUMAN | Serum-inducible kinase | Homo | <M><E><L><L><R><T><I><T><Y><Q><P><A><A><S><T><K><M><C><E><Q><A><L><G><K><G><C><G><A><D><S><K><K><K><R><P><P><Q><P><P><E><E><S><Q><P><P><Q><S><Q><A><Q><V><P><P><A><A><P><H><H><H><H><H><H><S><H><S><G><P><E><I><S><R><I><I><V><D><P><T><T><G><K><R><Y><C><R><G><K><V><L><G><K><G><G><F><A><K><C><Y><E><M><T><D><L><T><N><N><K><V><Y><A><A><K><I><I><P><H><S><R><V><A><K><P><H><Q><R><E><K><I><D><K><E><I><E><L><H><R><I><L><H><H><K><H><V><V><Q><F><Y><H><Y><F><E><D><K><E><N><I><Y><I><L><L><E><Y><C><S><R><R><S><M><A><H><I><L><K><A><R><K><V><L><T><E><P><E><V><R><Y><Y><L><R><Q><I><V><S><G><L><K><Y><L><H><E><Q><E><I><L><H><R><D><L><K><L><G><N><F><F><I><N><E><A><M><E><L><K><V><G><D><F><G><L><A><A><R><L><E><P><L><E><H><R><R><R><T><I><C><G><T><P><N><Y><L><S><P><E><V><L><N><K><Q><G><H><G><C><E><S><D><I><W><A><L><G><C><V><M><Y><T><M><L><L><G><R><P><P><F><E><T><T><N><L><K><E><T><Y><R><C><I><R><E><A><R><Y><T><M><P><S><S><L><L><A><P><A><K><H><L><I><A><S><M><L><S><K><N><P><E><D><R><P><S><L><D><D><I><I><R><H><D><F><F><L><Q><G><F><T><P><D><R><L><S><S><S><C><C><H><T><V><P><D><F><H><L><S><S><P><A><K><N><F><F><K><K><A><A><A><A><L><F><G><G><K><K><D><K><A><R><Y><I><D><T><H><N><R><V><S><K><E><D><E><D><I><Y><K><L><R><H><D><L><K><K><T><S><I><T><Q><Q><P><S><K><H><R><T><D><E><E><L><Q><P><P><T><T><T><V><A><R><S><G><T><P><A><V><E><N><K><Q><Q><I><G><D><A><I><R><M><I><V><R><G><T><L><G><S><C><S><S><S><S><E><C><L><E><D><S><T><M><G><S><V><A><D><T><V><A><R><V><L><R><G><C><L><E><N><M><P><E><A><D><C><I><P><K><E><Q><L><S><T><S><F><Q><W><V><T><K><W><V><D><Y><S><N><K><Y><G><F><G><Y><Q><L><S><D><H><T><V><G><V><L><F><N><N><G><A><H><M><S><L><L><P><D><K><K><T><V><H><Y><Y><A><E><L><G><Q><C><S><V><F><P><A><T><D><A><P><E><Q><F><I><S><Q><V><T><V><L><K><Y><F><S><H><Y><M><E><E><N><L><M><D><G><G><D><L><P><S><V><T><D><I><R><R><P><R><L><Y><L><L><Q><W><L><K><S><D><K><A><L><M><M><L><F><N><D><G><T><F><Q><V><N><F><Y><H><D><H><T><K><I><I><I><C><S><Q><N><E><E><Y><L><L><T><Y><I><N><E><D><R><I><S><T><T><F><R><L><T><T><L><L><M><S><G><C><S><S><E><L><K><N><R><M><E><Y><A><L><N><M><L><L><Q><R><C><N> | Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively | Q9NYY3 |
Q8IU85 | KCC1D_HUMAN | CaMKI-like protein kinase | Homo | <M><A><R><E><N><G><E><S><S><S><S><W><K><K><Q><A><E><D><I><K><K><I><F><E><F><K><E><T><L><G><T><G><A><F><S><E><V><V><L><A><E><E><K><A><T><G><K><L><F><A><V><K><C><I><P><K><K><A><L><K><G><K><E><S><S><I><E><N><E><I><A><V><L><R><K><I><K><H><E><N><I><V><A><L><E><D><I><Y><E><S><P><N><H><L><Y><L><V><M><Q><L><V><S><G><G><E><L><F><D><R><I><V><E><K><G><F><Y><T><E><K><D><A><S><T><L><I><R><Q><V><L><D><A><V><Y><Y><L><H><R><M><G><I><V><H><R><D><L><K><P><E><N><L><L><Y><Y><S><Q><D><E><E><S><K><I><M><I><S><D><F><G><L><S><K><M><E><G><K><G><D><V><M><S><T><A><C><G><T><P><G><Y><V><A><P><E><V><L><A><Q><K><P><Y><S><K><A><V><D><C><W><S><I><G><V><I><A><Y><I><L><L><C><G><Y><P><P><F><Y><D><E><N><D><S><K><L><F><E><Q><I><L><K><A><E><Y><E><F><D><S><P><Y><W><D><D><I><S><D><S><A><K><D><F><I><R><N><L><M><E><K><D><P><N><K><R><Y><T><C><E><Q><A><A><R><H><P><W><I><A><G><D><T><A><L><N><K><N><I><H><E><S><V><S><A><Q><I><R><K><N><F><A><K><S><K><W><R><Q><A><F><N><A><T><A><V><V><R><H><M><R><K><L><H><L><G><S><S><L><D><S><S><N><A><S><V><S><S><S><L><S><L><A><S><Q><K><D><C><L><A><P><S><T><L><C><S><F><I><S><S><S><S><G><V><S><G><V><G><A><E><R><R><P><R><P><T><T><V><T><A><V><H><S><G><S><K> | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<BOP> | Q8IU85 |
Q8NFA2 | NOXO1_HUMAN | SH3 and PX domain-containing protein 5 | Homo | <M><A><G><P><R><Y><P><V><S><V><Q><G><A><A><L><V><Q><I><K><R><L><Q><T><F><A><F><S><V><R><W><S><D><G><S><D><T><F><V><R><R><S><W><D><E><F><R><Q><L><K><K><T><L><K><E><T><F><P><V><E><A><G><L><L><R><R><S><D><R><V><L><P><K><L><L><G><Q><A><S><L><D><A><P><L><L><G><R><V><G><R><T><S><R><G><L><A><R><L><Q><L><L><E><T><Y><S><R><R><L><L><A><T><A><E><R><V><A><R><S><P><T><I><T><G><F><F><A><P><Q><P><L><D><L><E><P><A><L><P><P><G><S><R><V><I><L><P><T><P><E><E><Q><P><L><S><R><A><A><G><R><L><S><I><H><S><L><E><A><Q><S><L><R><C><L><Q><P><F><C><T><Q><D><T><R><D><R><P><F><Q><A><Q><A><Q><E><S><L><D><V><L><L><R><H><P><S><G><W><W><L><V><E><N><E><D><R><Q><T><A><W><F><P><A><P><Y><L><E><E><A><A><P><G><Q><G><R><E><G><G><P><S><L><G><S><S><G><P><Q><F><C><A><S><R><A><Y><E><S><S><R><A><D><E><L><S><V><P><A><G><A><R><V><R><V><L><E><T><S><D><R><G><W><W><L><C><R><Y><G><D><R><A><G><L><L><P><A><V><L><L><R><P><E><G><L><G><A><L><L><S><G><T><G><F><R><G><G><D><D><P><A><G><E><A><R><G><F><P><E><P><S><Q><A><T><A><P><P><P><T><V><P><T><R><P><S><P><G><A><I><Q><S><R><C><C><T><V><T><R><R><A><L><E><R><R><P><R><R><Q><G><R><P><R><G><C><V><D><S><V><P><H><P><T><T><E><Q> | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<BOP> | Q8NFA2 |
Q9H5Q4 | TFB2M_HUMAN | S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2 | Homo | <M><W><I><P><V><V><G><L><P><R><R><L><R><L><S><A><L><A><G><A><G><R><F><C><I><L><G><S><E><A><A><T><R><K><H><L><P><A><R><N><H><C><G><L><S><D><S><S><P><Q><L><W><P><E><P><D><F><R><N><P><P><R><K><A><S><K><A><S><L><D><F><K><R><Y><V><T><D><R><R><L><A><E><T><L><A><Q><I><Y><L><G><K><P><S><R><P><P><H><L><L><L><E><C><N><P><G><P><G><I><L><T><Q><A><L><L><E><A><G><A><K><V><V><A><L><E><S><D><K><T><F><I><P><H><L><E><S><L><G><K><N><L><D><G><K><L><R><V><I><H><C><D><F><F><K><L><D><P><R><S><G><G><V><I><K><P><P><A><M><S><S><R><G><L><F><K><N><L><G><I><E><A><V><P><W><T><A><D><I><P><L><K><V><V><G><M><F><P><S><R><G><E><K><R><A><L><W><K><L><A><Y><D><L><Y><S><C><T><S><I><Y><K><F><G><R><I><E><V><N><M><F><I><G><E><K><E><F><Q><K><L><M><A><D><P><G><N><P><D><L><Y><H><V><L><S><V><I><W><Q><L><A><C><E><I><K><V><L><H><M><E><P><W><S><S><F><D><I><Y><T><R><K><G><P><L><E><N><P><K><R><R><E><L><L><D><Q><L><Q><Q><K><L><Y><L><I><Q><M><I><P><R><Q><N><L><F><T><K><N><L><T><P><M><N><Y><N><I><F><F><H><L><L><K><H><C><F><G><R><R><S><A><T><V><I><D><H><L><R><S><L><T><P><L><D><A><R><D><I><L><M><Q><I><G><K><Q><E><D><E><K><V><V><N><M><H><P><Q><D><F><K><T><L><F><E><T><I><E><R><S><K><D><C><A><Y><K><W><L><Y><D><E><T><L><E><D><R> | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA . In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand . Stimulates transcription independently of the methyltransferase activity .<BOP> | Q9H5Q4 |
Q96PQ1 | SIG12_HUMAN | Sialic acid-binding Ig-like lectin-like 1 | Homo | <M><L><L><L><L><L><L><L><P><P><L><L><C><G><R><V><G><A><K><E><Q><K><D><Y><L><L><T><M><Q><K><S><V><T><V><Q><E><G><L><C><V><S><V><L><C><S><F><S><Y><P><Q><N><G><W><T><A><S><D><P><V><H><G><Y><W><F><R><A><G><D><H><V><S><R><N><I><P><V><A><T><N><N><P><A><R><A><V><Q><E><E><T><R><D><R><F><H><L><L><G><D><P><Q><N><K><D><C><T><L><S><I><R><D><T><R><E><S><D><A><G><T><Y><V><F><C><V><E><R><G><N><M><K><W><N><Y><K><Y><D><Q><L><S><V><N><V><T><A><S><Q><D><L><L><S><R><Y><R><L><E><V><P><E><S><V><T><V><Q><E><G><L><C><V><S><V><P><C><S><V><L><Y><P><H><Y><N><W><T><A><S><S><P><V><Y><G><S><W><F><K><E><G><A><D><I><P><W><D><I><P><V><A><T><N><T><P><S><G><K><V><Q><E><D><T><H><G><R><F><L><L><L><G><D><P><Q><T><N><N><C><S><L><S><I><R><D><A><R><K><G><D><S><G><K><Y><Y><F><Q><V><E><R><G><S><R><K><W><N><Y><I><Y><D><K><L><S><V><H><V><T><A><L><T><H><M><P><T><F><S><I><P><G><T><L><E><S><G><H><P><R><N><L><T><C><S><V><P><W><A><C><E><Q><G><T><P><P><T><I><T><W><M><G><A><S><V><S><S><L><D><P><T><I><T><R><S><S><M><L><S><L><I><P><Q><P><Q><D><H><G><T><S><L><T><C><Q><V><T><L><P><G><A><G><V><T><M><T><R><A><V><R><L><N><I><S><Y><P><P><Q><N><L><T><M><T><V><F><Q><G><D><G><T><A><S><T><T><L><R><N><G><S><A><L><S><V><L><E><G><Q><S><L><H><L><V><C><A><V><D><S><N><P><P><A><R><L><S><W><T><W><G><S><L><T><L><S><P><S><Q><S><S><N><L><G><V><L><E><L><P><R><V><H><V><K><D><E><G><E><F><T><C><R><A><Q><N><P><L><G><S><Q><H><I><S><L><S><L><S><L><Q><N><E><Y><T><G><K><M><R><P><I><S><G><V><T><L><G><A><F><G><G><A><G><A><T><A><L><V><F><L><Y><F><C><I><I><F><V><V><V><R><S><C><R><K><K><S><A><R><P><A><V><G><V><G><D><T><G><M><E><D><A><N><A><V><R><G><S><A><S><Q><G><P><L><I><E><S><P><A><D><D><S><P><P><H><H><A><P><P><A><L><A><T><P><S><P><E><E><G><E><I><Q><Y><A><S><L><S><F><H><K><A><R><P><Q><Y><P><Q><E><Q><E><A><I><G><Y><E><Y><S><E><I><N><I><P><K> | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.<BOP> | Q96PQ1 |
O43556 | SGCE_HUMAN | Epsilon-sarcoglycan | Homo | <M><Q><L><P><R><W><W><E><L><G><D><P><C><A><W><T><G><Q><G><R><G><T><R><R><M><S><P><A><T><T><G><T><F><L><L><T><V><Y><S><I><F><S><K><V><H><S><D><R><N><V><Y><P><S><A><G><V><L><F><V><H><V><L><E><R><E><Y><F><K><G><E><F><P><P><Y><P><K><P><G><E><I><S><N><D><P><I><T><F><N><T><N><L><M><G><Y><P><D><R><P><G><W><L><R><Y><I><Q><R><T><P><Y><S><D><G><V><L><Y><G><S><P><T><A><E><N><V><G><K><P><T><I><I><E><I><T><A><Y><N><R><R><T><F><E><T><A><R><H><N><L><I><I><N><I><M><S><A><E><D><F><P><L><P><Y><Q><A><E><F><F><I><K><N><M><N><V><E><E><M><L><A><S><E><V><L><G><D><F><L><G><A><V><K><N><V><W><Q><P><E><R><L><N><A><I><N><I><T><S><A><L><D><R><G><G><R><V><P><L><P><I><N><D><L><K><E><G><V><Y><V><M><V><G><A><D><V><P><F><S><S><C><L><R><E><V><E><N><P><Q><N><Q><L><R><C><S><Q><E><M><E><P><V><I><T><C><D><K><K><F><R><T><Q><F><Y><I><D><W><C><K><I><S><L><V><D><K><T><K><Q><V><S><T><Y><Q><E><V><I><R><G><E><G><I><L><P><D><G><G><E><Y><K><P><P><S><D><S><L><K><S><R><D><Y><Y><T><D><F><L><I><T><L><A><V><P><S><A><V><A><L><V><L><F><L><I><L><A><Y><I><M><C><C><R><R><E><G><V><E><K><R><N><M><Q><T><P><D><I><Q><L><V><H><H><S><A><I><Q><K><S><T><K><E><L><R><D><M><S><K><N><R><E><I><A><W><P><L><S><T><L><P><V><F><H><P><V><T><G><E><I><I><P><P><L><H><T><D><N><Y><D><S><T><N><M><P><L><M><Q><T><Q><Q><N><L><P><H><Q><T><Q><I><P><Q><Q><Q><T><T><G><K><W><Y><P> | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.<BOP> | O43556 |
Q8IZF4 | AGRG5_HUMAN | G-protein coupled receptor PGR27 | Homo | <M><D><H><C><G><A><L><F><L><C><L><C><L><L><T><L><Q><N><A><T><T><E><T><W><E><E><L><L><S><Y><M><E><N><M><Q><V><S><R><G><R><S><S><V><F><S><S><R><Q><L><H><Q><L><E><Q><M><L><L><N><T><S><F><P><G><Y><N><L><T><L><Q><T><P><T><I><Q><S><L><A><F><K><L><S><C><D><F><S><G><L><S><L><T><S><A><T><L><K><R><V><P><Q><A><G><G><Q><H><A><R><G><Q><H><A><M><Q><F><P><A><E><L><T><R><D><A><C><K><T><R><P><R><E><L><R><L><I><C><I><Y><F><S><N><T><H><F><F><K><D><E><N><N><S><S><L><L><N><N><Y><V><L><G><A><Q><L><S><H><G><H><V><N><N><L><R><D><P><V><N><I><S><F><W><H><N><Q><S><L><E><G><Y><T><L><T><C><V><F><W><K><E><G><A><R><K><Q><P><W><G><G><W><S><P><E><G><C><R><T><E><Q><P><S><H><S><Q><V><L><C><R><C><N><H><L><T><Y><F><A><V><L><M><Q><L><S><P><A><L><V><P><A><E><L><L><A><P><L><T><Y><I><S><L><V><G><C><S><I><S><I><V><A><S><L><I><T><V><L><L><H><F><H><F><R><K><Q><S><D><S><L><T><R><I><H><M><N><L><H><A><S><V><L><L><L><N><I><A><F><L><L><S><P><A><F><A><M><S><P><V><P><G><S><A><C><T><A><L><A><A><A><L><H><Y><A><L><L><S><C><L><T><W><M><A><I><E><G><F><N><L><Y><L><L><L><G><R><V><Y><N><I><Y><I><R><R><Y><V><F><K><L><G><V><L><G><W><G><A><P><A><L><L><V><L><L><S><L><S><V><K><S><S><V><Y><G><P><C><T><I><P><V><F><D><S><W><E><N><G><T><G><F><Q><N><M><S><I><C><W><V><R><S><P><V><V><H><S><V><L><V><M><G><Y><G><G><L><T><S><L><F><N><L><V><V><L><A><W><A><L><W><T><L><R><R><L><R><E><R><A><D><A><P><S><V><R><A><C><H><D><T><V><T><V><L><G><L><T><V><L><L><G><T><T><W><A><L><A><F><F><S><F><G><V><F><L><L><P><Q><L><F><L><F><T><I><L><N><S><L><Y><G><F><F><L><F><L><W><F><C><S><Q><R><C><R><S><E><A><E><A><K><A><Q><I><E><A><F><S><S><S><Q><T><T><Q> | Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).<BOP> | Q8IZF4 |
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