accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P30926 | ACHB4_HUMAN | Neuronal acetylcholine receptor subunit beta-4 | Homo | <M><R><R><A><P><S><L><V><L><F><F><L><V><A><L><C><G><R><G><N><C><R><V><A><N><A><E><E><K><L><M><D><D><L><L><N><K><T><R><Y><N><N><L><I><R><P><A><T><S><S><S><Q><L><I><S><I><K><L><Q><L><S><L><A><Q><L><I><S><V><N><E><R><E><Q><I><M><T><T><N><V><W><L><K><Q><E><W><T><D><Y><R><L><T><W><N><S><S><R><Y><E><G><V><N><I><L><R><I><P><A... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | P30926 |
P02585 | TNNC2_HUMAN | Troponin C, skeletal muscle | Homo | <M><T><D><Q><Q><A><E><A><R><S><Y><L><S><E><E><M><I><A><E><F><K><A><A><F><D><M><F><D><A><D><G><G><G><D><I><S><V><K><E><L><G><T><V><M><R><M><L><G><Q><T><P><T><K><E><E><L><D><A><I><I><E><E><V><D><E><D><G><S><G><T><I><D><F><E><E><F><L><V><M><M><V><R><Q><M><K><E><D><A><K><G><K><S><E><E><E><L><A><E><C><F><R><I><F><D><R><N><A... | Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.<BOP> | P02585 |
Q643R3 | LPCT4_HUMAN | Plasmalogen synthase | Homo | <M><S><Q><G><S><P><G><D><W><A><P><L><D><P><T><P><G><P><P><A><S><P><N><P><F><V><H><E><L><H><L><S><R><L><Q><R><V><K><F><C><L><L><G><A><L><L><A><P><I><R><V><L><L><A><F><I><V><L><F><L><L><W><P><F><A><W><L><Q><V><A><G><L><S><E><E><Q><L><Q><E><P><I><T><G><W><R><K><T><V><C><H><N><G><V><L><G><L><S><R><L><L><F><F><L><L><G><F><L... | Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphat... | Q643R3 |
P09341 | GROA_HUMAN | GRO-alpha(6-73) | Homo | <M><A><R><A><A><L><S><A><A><P><S><N><P><R><L><L><R><V><A><L><L><L><L><L><L><V><A><A><G><R><R><A><A><G><A><S><V><A><T><E><L><R><C><Q><C><L><Q><T><L><Q><G><I><H><P><K><N><I><Q><S><V><N><V><K><S><P><G><P><H><C><A><Q><T><E><V><I><A><T><L><K><N><G><R><K><A><C><L><N><P><A><S><P><I><V><K><K><I><I><E><K><M><L><N><S><D><K><S><N... | Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.<BOP> | P09341 |
Q8WW01 | SEN15_HUMAN | tRNA-intron endonuclease Sen15 | Homo | <M><E><E><R><G><D><S><E><P><T><P><G><C><S><G><L><G><P><G><G><V><R><G><F><G><D><G><G><G><A><P><S><W><A><P><E><D><A><W><M><G><T><H><P><K><Y><L><E><M><M><E><L><D><I><G><D><A><T><Q><V><Y><V><A><F><L><V><Y><L><D><L><M><E><S><K><S><W><H><E><V><N><C><V><G><L><P><E><L><Q><L><I><C><L><V><G><T><E><I><E><G><E><G><L><Q><T><V><V><P... | Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH... | Q8WW01 |
P36639 | 8ODP_HUMAN | Nucleoside diphosphate-linked moiety X motif 1 | Homo | <M><G><A><S><R><L><Y><T><L><V><L><V><L><Q><P><Q><R><V><L><L><G><M><K><K><R><G><F><G><A><G><R><W><N><G><F><G><G><K><V><Q><E><G><E><T><I><E><D><G><A><R><R><E><L><Q><E><E><S><G><L><T><V><D><A><L><H><K><V><G><Q><I><V><F><E><F><V><G><E><P><E><L><M><D><V><H><V><F><C><T><D><S><I><Q><G><T><P><V><E><S><D><E><M><R><P><C><W><F><Q... | Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool . Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP . Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP . Through the hydrolysis of oxidized purine n... | P36639 |
P48023 | TNFL6_HUMAN | SPPL2A-processed FasL form | Homo | <M><Q><Q><P><F><N><Y><P><Y><P><Q><I><Y><W><V><D><S><S><A><S><S><P><W><A><P><P><G><T><V><L><P><C><P><T><S><V><P><R><R><P><G><Q><R><R><P><P><P><P><P><P><P><P><P><L><P><P><P><P><P><P><P><P><L><P><P><L><P><L><P><P><L><K><K><R><G><N><H><S><T><G><L><C><L><L><V><M><F><F><M><V><L><V><A><L><V><G><L><G><L><G><M><F><Q><L><F><H><L... | Cytoplasmic form induces gene transcription inhibition.<BOP> | P48023 |
O75449 | KTNA1_HUMAN | p60 katanin | Homo | <M><S><L><L><M><I><S><E><N><V><K><L><A><R><E><Y><A><L><L><G><N><Y><D><S><A><M><V><Y><Y><Q><G><V><L><D><Q><M><N><K><Y><L><Y><S><V><K><D><T><Y><L><Q><Q><K><W><Q><Q><V><W><Q><E><I><N><V><E><A><K><H><V><K><D><I><M><K><T><L><E><S><F><K><L><D><S><T><P><L><K><A><A><Q><H><D><L><P><A><S><E><G><E><V><W><S><M><P><V><P><V><E><R><R... | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerizatio... | O75449 |
Q8IVL6 | P3H3_HUMAN | Protein B | Homo | <M><L><R><L><L><R><P><L><L><L><L><L><L><L><P><P><P><G><S><P><E><P><P><G><L><T><Q><L><S><P><G><A><P><P><Q><A><P><D><L><L><Y><A><D><G><L><R><A><Y><A><A><G><A><W><A><P><A><V><A><L><L><R><E><A><L><R><S><Q><A><A><L><G><R><V><R><L><D><C><G><A><S><C><A><A><D><P><G><A><A><L><P><A><V><L><L><G><A><P><E><P><D><S><G><P><G><P><T><Q... | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. ... | Q8IVL6 |
O43731 | ERD23_HUMAN | KDEL endoplasmic reticulum protein retention receptor 3 | Homo | <M><N><V><F><R><I><L><G><D><L><S><H><L><L><A><M><I><L><L><L><G><K><I><W><R><S><K><C><C><K><G><I><S><G><K><S><Q><I><L><F><A><L><V><F><T><T><R><Y><L><D><L><F><T><N><F><I><S><I><Y><N><T><V><M><K><V><V><F><L><L><C><A><Y><V><T><V><Y><M><I><Y><G><K><F><R><K><T><F><D><S><E><N><D><T><F><R><L><E><F><L><L><V><P><V><I><G><L><S><F... | Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.<BOP> | O43731 |
P52209 | 6PGD_HUMAN | 6-phosphogluconate dehydrogenase, decarboxylating | Homo | <M><A><Q><A><D><I><A><L><I><G><L><A><V><M><G><Q><N><L><I><L><N><M><N><D><H><G><F><V><V><C><A><F><N><R><T><V><S><K><V><D><D><F><L><A><N><E><A><K><G><T><K><V><V><G><A><Q><S><L><K><E><M><V><S><K><L><K><K><P><R><R><I><I><L><L><V><K><A><G><Q><A><V><D><D><F><I><E><K><L><V><P><L><L><D><T><G><D><I><I><I><D><G><G><N><S><E><Y><R... | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.<BOP> | P52209 |
Q9BPU9 | B9D2_HUMAN | MKS1-related protein 2 | Homo | <M><A><E><V><H><V><I><G><Q><I><I><G><A><S><G><F><S><E><S><S><L><F><C><K><W><G><I><H><T><G><A><A><W><K><L><L><S><G><V><R><E><G><Q><T><Q><V><D><T><P><Q><I><G><D><M><A><Y><W><S><H><P><I><D><L><H><F><A><T><K><G><L><Q><G><W><P><R><L><H><F><Q><V><W><S><Q><D><S><F><G><R><C><Q><L><A><G><Y><G><F><C><H><V><P><S><S><P><G><T><H><Q... | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.<BOP> | Q9BPU9 |
A0A0J9YXM7 | TJB15_HUMAN | T cell receptor beta joining 1-5 | Homo | <S><N><Q><P><Q><H><F><G><D><G><T><R><L><S><I><L> | J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (p... | A0A0J9YXM7 |
Q9UKZ9 | PCOC2_HUMAN | Procollagen COOH-terminal proteinase enhancer 2 | Homo | <M><R><G><A><N><A><W><A><P><L><C><L><L><L><A><A><A><T><Q><L><S><R><Q><Q><S><P><E><R><P><V><F><T><C><G><G><I><L><T><G><E><S><G><F><I><G><S><E><G><F><P><G><V><Y><P><P><N><S><K><C><T><W><K><I><T><V><P><E><G><K><V><V><V><L><N><F><R><F><I><D><L><E><S><D><N><L><C><R><Y><D><F><V><D><V><Y><N><G><H><A><N><G><Q><R><I><G><R><F><C... | Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.<BOP> | Q9UKZ9 |
Q8NH94 | OR1L1_HUMAN | Olfactory receptor OR9-27 | Homo | <M><E><R><N><H><N><P><D><N><C><N><V><L><N><F><F><F><A><D><K><K><N><K><R><R><N><F><G><Q><I><V><S><D><V><G><R><I><C><Y><S><V><S><L><S><L><G><E><P><T><T><M><G><R><N><N><L><T><R><P><S><E><F><I><L><L><G><L><S><S><R><P><E><D><Q><K><P><L><F><A><V><F><L><P><I><Y><L><I><T><V><I><G><N><L><L><I><I><L><A><I><R><S><D><T><R><L><Q><T... | Odorant receptor.<BOP> | Q8NH94 |
O95409 | ZIC2_HUMAN | Zinc finger protein of the cerebellum 2 | Homo | <M><L><L><D><A><G><P><Q><F><P><A><I><G><V><G><S><F><A><R><H><H><H><H><S><A><A><A><A><A><A><A><A><A><E><M><Q><D><R><E><L><S><L><A><A><A><Q><N><G><F><V><D><S><A><A><A><H><M><G><A><F><K><L><N><P><G><A><H><E><L><S><P><G><Q><S><S><A><F><T><S><Q><G><P><G><A><Y><P><G><S><A><A><A><A><A><A><A><A><A><L><G><P><H><A><A><H><V><G><S... | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional ... | O95409 |
P23276 | KELL_HUMAN | Kell blood group glycoprotein | Homo | <M><E><G><G><D><Q><S><E><E><E><P><R><E><R><S><Q><A><G><G><M><G><T><L><W><S><Q><E><S><T><P><E><E><R><L><P><V><E><G><S><R><P><W><A><V><A><R><R><V><L><T><A><I><L><I><L><G><L><L><L><C><F><S><V><L><L><F><Y><N><F><Q><N><C><G><P><R><P><C><E><T><S><V><C><L><D><L><R><D><H><Y><L><A><S><G><N><T><S><V><A><P><C><T><D><F><F><S><F><A... | Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.<BOP> | P23276 |
Q9Y450 | HBS1L_HUMAN | ERFS | Homo | <M><A><R><H><R><N><V><R><G><Y><N><Y><D><E><D><F><E><D><D><D><L><Y><G><Q><S><V><E><D><D><Y><C><I><S><P><S><T><A><A><Q><F><I><Y><S><R><R><D><K><P><S><V><E><P><V><E><E><Y><D><Y><E><D><L><K><E><S><S><N><S><V><S><N><H><Q><L><S><G><F><D><Q><A><R><L><Y><S><C><L><D><H><M><R><E><V><L><G><D><A><V><P><D><E><I><L><I><E><A><V><L><K... | Facilitates the association of the exosome complex with the SKI complex.<BOP> | Q9Y450 |
Q5T280 | CI114_HUMAN | SPOUT domain-containing methyltransferase 1 | Homo | <M><A><E><R><G><R><K><R><P><C><G><P><G><E><H><G><Q><R><I><E><W><R><K><W><K><Q><Q><K><K><E><E><K><K><K><W><K><D><L><K><L><M><K><K><L><E><R><Q><R><A><Q><E><E><Q><A><K><R><L><E><E><E><E><A><A><A><E><K><E><D><R><G><R><P><Y><T><L><S><V><A><L><P><G><S><I><L><D><N><A><Q><S><P><E><L><R><T><Y><L><A><G><Q><I><A><R><A><C><A><I><F... | Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase . Also involved in chromosome alignment . May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis . Binds specifically to miRNA MIR145 hairpin, regula... | Q5T280 |
Q9HC96 | CAN10_HUMAN | Calcium-activated neutral proteinase 10 | Homo | <M><R><A><G><R><G><A><T><P><A><R><E><L><F><R><D><A><A><F><P><A><A><D><S><S><L><F><C><D><L><S><T><P><L><A><Q><F><R><E><D><I><T><W><R><R><P><Q><E><I><C><A><T><P><R><L><F><P><D><D><P><R><E><G><Q><V><K><Q><G><L><L><G><D><C><W><F><L><C><A><C><A><A><L><Q><K><S><R><H><L><L><D><Q><V><I><P><P><G><Q><P><S><W><A><D><Q><E><Y><R><G... | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.<BOP> | Q9HC96 |
Q0D2J5 | ZN763_HUMAN | Zinc finger protein 763 | Homo | <M><D><P><V><A><C><E><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><D><I><S><Q><R><K><L><Y><R><E><V><M><L><E><T><F><R><N><L><T><S><I><G><K><K><W><K><D><Q><N><I><E><Y><E><Y><Q><N><P><R><R><N><F><R><S><L><I><E><G><N><V><N><E><I><K><E><D><S><H><C><G><E><T><F><T><Q><V><P><D><D><R><L><N><F><Q><E><K><K><A><S><P><E><A><K><S><C><D... | May be involved in transcriptional regulation.<BOP> | Q0D2J5 |
Q8NGQ5 | OR9Q1_HUMAN | Olfactory receptor 9Q1 | Homo | <M><A><E><M><N><L><T><L><V><T><E><F><L><L><I><A><F><T><E><Y><P><E><W><A><L><P><L><F><L><L><F><L><F><M><Y><L><I><T><V><L><G><N><L><E><M><I><I><L><I><L><M><D><H><Q><L><H><A><P><M><Y><F><L><L><S><H><L><A><F><M><D><V><C><Y><S><S><I><T><V><P><Q><M><L><A><V><L><L><E><H><G><A><A><L><S><Y><T><R><C><A><A><Q><F><F><L><F><T><F><F... | Odorant receptor.<BOP> | Q8NGQ5 |
Q9NPC6 | MYOZ2_HUMAN | FATZ-related protein 2 | Homo | <M><L><S><H><N><T><M><M><K><Q><R><K><Q><Q><A><T><A><I><M><K><E><V><H><G><N><D><V><D><G><M><D><L><G><K><K><V><S><I><P><R><D><I><M><L><E><E><L><S><H><L><S><N><R><G><A><R><L><F><K><M><R><Q><R><R><S><D><K><Y><T><F><E><N><F><Q><Y><Q><S><R><A><Q><I><N><H><S><I><A><M><Q><N><G><K><V><D><G><S><N><L><E><G><G><S><Q><Q><A><P><L><T... | Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.<BOP... | Q9NPC6 |
Q9ULW8 | PADI3_HUMAN | Protein-arginine deiminase type III | Homo | <M><S><L><Q><R><I><V><R><V><S><L><E><H><P><T><S><A><V><C><V><A><G><V><E><T><L><V><D><I><Y><G><S><V><P><E><G><T><E><M><F><E><V><Y><G><T><P><G><V><D><I><Y><I><S><P><N><M><E><R><G><R><E><R><A><D><T><R><R><W><R><F><D><A><T><L><E><I><I><V><V><M><N><S><P><S><N><D><L><N><D><S><H><V><Q><I><S><Y><H><S><S><H><E><P><L><P><L><A><Y... | Catalyzes the deimination of arginine residues of proteins.<BOP> | Q9ULW8 |
P36980 | FHR2_HUMAN | H factor-like protein 2 | Homo | <M><W><L><L><V><S><V><I><L><I><S><R><I><S><S><V><G><G><E><A><M><F><C><D><F><P><K><I><N><H><G><I><L><Y><D><E><E><K><Y><K><P><F><S><Q><V><P><T><G><E><V><F><Y><Y><S><C><E><Y><N><F><V><S><P><S><K><S><F><W><T><R><I><T><C><A><E><E><G><W><S><P><T><P><K><C><L><R><L><C><F><F><P><F><V><E><N><G><H><S><E><S><S><G><Q><T><H><L><E><G... | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.<BOP> | P36980 |
P21506 | ZNF10_HUMAN | Zinc finger protein KOX1 | Homo | <M><D><A><K><S><L><T><A><W><S><R><T><L><V><T><F><K><D><V><F><V><D><F><T><R><E><E><W><K><L><L><D><T><A><Q><Q><I><V><Y><R><N><V><M><L><E><N><Y><K><N><L><V><S><L><G><Y><Q><L><T><K><P><D><V><I><L><R><L><E><K><G><E><E><P><W><L><V><E><R><E><I><H><Q><E><T><H><P><D><S><E><T><A><F><E><I><K><S><S><V><S><S><R><S><I><F><K><D><K><Q... | May be involved in transcriptional regulation.<BOP> | P21506 |
Q8TBN0 | R3GEF_HUMAN | null | Homo | <M><W><S><G><P><P><Q><P><D><Q><G><L><P><P><P><L><A><A><V><P><V><P><W><K><S><T><D><P><C><Q><G><H><R><E><S><P><G><A><L><V><E><T><S><A><G><E><E><A><Q><G><Q><E><G><P><A><A><A><Q><L><D><V><L><R><L><R><S><S><S><M><E><I><R><E><K><G><S><E><F><L><K><E><E><L><H><R><A><Q><K><E><L><K><L><K><D><E><E><C><E><R><L><S><K><V><R><E><Q><L... | Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.<BOP> | Q8TBN0 |
Q9Y2Y6 | TMM98_HUMAN | Protein TADA1 | Homo | <M><E><T><V><V><I><V><A><I><G><V><L><A><T><I><F><L><A><S><F><A><A><L><V><L><V><C><R><Q><R><Y><C><R><P><R><D><L><L><Q><R><Y><D><S><K><P><I><V><D><L><I><G><A><M><E><T><Q><S><E><P><S><E><L><E><L><D><D><V><V><I><T><N><P><H><I><E><A><I><L><E><N><E><D><W><I><E><D><A><S><G><L><M><S><H><C><I><A><I><L><K><I><C><H><T><L><T><E><K... | Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).<BOP> | Q9Y2Y6 |
A5D8V6 | VP37C_HUMAN | ESCRT-I complex subunit VPS37C | Homo | <M><E><T><L><K><D><K><T><L><Q><E><L><E><E><L><Q><N><D><S><E><A><I><D><Q><L><A><L><E><S><P><E><V><Q><D><L><Q><L><E><R><E><M><A><L><A><T><N><R><S><L><A><E><R><N><L><E><F><Q><G><P><L><E><I><S><R><S><N><L><S><D><R><Y><Q><E><L><R><K><L><V><E><R><C><Q><E><Q><K><A><K><L><E><K><F><S><S><A><L><Q><P><G><T><L><L><D><L><L><Q><V><E... | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.<BOP> | A5D8V6 |
Q99712 | KCJ15_HUMAN | Potassium channel, inwardly rectifying subfamily J member 15 | Homo | <M><D><A><I><H><I><G><M><S><S><T><P><L><V><K><H><T><A><G><A><G><L><K><A><N><R><P><R><V><M><S><K><S><G><H><S><N><V><R><I><D><K><V><D><G><I><Y><L><L><Y><L><Q><D><L><W><T><T><V><I><D><M><K><W><R><Y><K><L><T><L><F><A><A><T><F><V><M><T><W><F><L><F><G><V><I><Y><Y><A><I><A><F><I><H><G><D><L><E><P><G><E><P><I><S><N><H><T><P><C... | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more posi... | Q99712 |
P13798 | ACPH_HUMAN | Oxidized protein hydrolase | Homo | <M><E><R><Q><V><L><L><S><E><P><E><E><A><A><A><L><Y><R><G><L><S><R><Q><P><A><L><S><A><A><C><L><G><P><E><V><T><T><Q><Y><G><G><Q><Y><R><T><V><H><T><E><W><T><Q><R><D><L><E><R><M><E><N><I><R><F><C><R><Q><Y><L><V><F><H><D><G><D><S><V><V><F><A><G><P><A><G><N><S><V><E><T><R><G><E><L><L><S><R><E><S><P><S><G><T><M><K><A><V><L><R... | This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.<BOP> | P13798 |
P08962 | CD63_HUMAN | Tetraspanin-30 | Homo | <M><A><V><E><G><G><M><K><C><V><K><F><L><L><Y><V><L><L><L><A><F><C><A><C><A><V><G><L><I><A><V><G><V><G><A><Q><L><V><L><S><Q><T><I><I><Q><G><A><T><P><G><S><L><L><P><V><V><I><I><A><V><G><V><F><L><F><L><V><A><F><V><G><C><C><G><A><C><K><E><N><Y><C><L><M><I><T><F><A><I><F><L><S><L><I><M><L><V><E><V><A><A><A><I><A><G><Y><V><F... | Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spr... | P08962 |
Q99469 | STAC_HUMAN | Src homology 3 and cysteine-rich domain-containing protein | Homo | <M><I><P><P><S><S><P><R><E><D><G><V><D><G><L><P><K><E><A><V><G><A><E><Q><P><P><S><P><A><S><T><S><S><Q><E><S><K><L><Q><K><L><K><R><S><L><S><F><K><T><K><S><L><R><S><K><S><A><D><N><F><F><Q><R><T><N><S><E><D><M><K><L><Q><A><H><M><V><A><E><I><S><P><S><S><S><P><L><P><A><P><G><S><L><T><S><T><P><A><R><A><G><L><H><P><G><G><K><A... | Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactiva... | Q99469 |
P01742 | HV169_HUMAN | Ig heavy chain V-I region WOL | Homo | <M><D><W><T><W><R><F><L><F><V><V><A><A><A><T><G><V><Q><S><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><S><S><V><K><V><S><C><K><A><S><G><G><T><F><S><S><Y><A><I><S><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><G><I><I><P><I><F><G><T><A><N><Y><A><Q><K><F><Q><G><R><V><T><I><T><A><D><K><S><T><S><T><A><Y><M><E><L><S><S><L><R><S... | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P01742 |
Q9UET6 | TRM7_HUMAN | Protein ftsJ homolog 1 | Homo | <M><G><R><T><S><K><D><K><R><D><V><Y><Y><R><L><A><K><E><N><G><W><R><A><R><S><A><F><K><L><L><Q><L><D><K><E><F><Q><L><F><Q><G><V><T><R><A><V><D><L><C><A><A><P><G><S><W><S><Q><V><L><S><Q><K><I><G><G><Q><G><S><G><H><V><V><A><V><D><L><Q><A><M><A><P><L><P><G><V><V><Q><I><Q><G><D><I><T><Q><L><S><T><A><K><E><I><I><Q><H><F><K><G... | Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.<BOP> | Q9UET6 |
Q6ZMM2 | ATL5_HUMAN | Thrombospondin type-1 domain-containing protein 6 | Homo | <M><G><K><L><R><P><G><R><V><E><W><L><A><S><G><H><T><E><R><P><H><L><F><Q><N><L><L><L><F><L><W><A><L><L><N><C><G><L><G><V><S><A><Q><G><P><G><E><W><T><P><W><V><S><W><T><R><C><S><S><S><C><G><R><G><V><S><V><R><S><R><R><C><L><R><L><P><G><E><E><P><C><W><G><D><S><H><E><Y><R><L><C><Q><L><P><D><C><P><P><G><A><V><P><F><R><D><L><Q... | May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).<BOP> | Q6ZMM2 |
O14925 | TIM23_HUMAN | Mitochondrial import inner membrane translocase subunit Tim23 | Homo | <M><E><G><G><G><G><S><G><N><K><T><T><G><G><L><A><G><F><F><G><A><G><G><A><G><Y><S><H><A><D><L><A><G><V><P><L><T><G><M><N><P><L><S><P><Y><L><N><V><D><P><R><Y><L><V><Q><D><T><D><E><F><I><L><P><T><G><A><N><K><T><R><G><R><F><E><L><A><F><F><T><I><G><G><C><C><M><T><G><A><A><F><G><A><M><N><G><L><R><L><G><L><K><E><T><Q><N><M><A... | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.<BOP> | O14925 |
Q9UIK4 | DAPK2_HUMAN | DAP-kinase-related protein 1 | Homo | <M><F><Q><A><S><M><R><S><P><N><M><E><P><F><K><Q><Q><K><V><E><D><F><Y><D><I><G><E><E><L><G><S><G><Q><F><A><I><V><K><K><C><R><E><K><S><T><G><L><E><Y><A><A><K><F><I><K><K><R><Q><S><R><A><S><R><R><G><V><S><R><E><E><I><E><R><E><V><S><I><L><R><Q><V><L><H><H><N><V><I><T><L><H><D><V><Y><E><N><R><T><D><V><V><L><I><L><E><L><V><S... | Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.<BOP> | Q9UIK4 |
Q9UJX4 | APC5_HUMAN | Cyclosome subunit 5 | Homo | <M><A><S><V><H><E><S><L><Y><F><N><P><M><M><T><N><G><V><V><H><A><N><V><F><G><I><K><D><W><V><T><P><Y><K><I><A><V><L><V><L><L><N><E><M><S><R><T><G><E><G><A><V><S><L><M><E><R><R><R><L><N><Q><L><L><L><P><L><L><Q><G><P><D><I><T><L><S><K><L><Y><K><L><I><E><E><S><C><P><Q><L><A><N><S><V><Q><I><R><I><K><L><M><A><E><G><E><L><K><D... | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'L... | Q9UJX4 |
P62308 | RUXG_HUMAN | Sm protein G | Homo | <M><S><K><A><H><P><P><E><L><K><K><F><M><D><K><K><L><S><L><K><L><N><G><G><R><H><V><Q><G><I><L><R><G><F><D><P><F><M><N><L><V><I><D><E><C><V><E><M><A><T><S><G><Q><Q><N><N><I><G><M><V><V><I><R><G><N><S><I><I><M><L><E><A><L><E><R><V> | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome . Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes . Is also a component of the minor U12 spliceoso... | P62308 |
Q7Z572 | SPT21_HUMAN | Spermatogenesis-associated protein 21 | Homo | <M><D><N><R><N><T><Q><M><Y><T><E><E><E><K><T><V><N><P><F><L><P><S><T><P><G><P><K><K><A><K><G><G><G><E><A><V><E><T><H><P><A><P><G><P><L><P><P><P><E><V><R><D><I><G><E><R><R><E><P><D><R><A><Q><Q><Q><P><Q><K><P><A><V><A><A><G><T><Q><S><L><G><N><F><R><Q><G><F><M><K><C><L><L><E><V><E><K><M><E><A><S><H><R><R><A><S><K><A><R><S... | Involved in the differentiation of haploid spermatids.<BOP> | Q7Z572 |
Q5SRE7 | PHYD1_HUMAN | Phytanoyl-CoA dioxygenase domain-containing protein 1 | Homo | <M><A><C><L><S><P><S><Q><L><Q><K><F><Q><Q><D><G><F><L><V><L><E><G><F><L><S><A><E><E><C><V><A><M><Q><Q><R><I><G><E><I><V><A><E><M><D><V><P><L><H><C><R><T><E><F><S><T><Q><E><E><E><Q><L><R><A><Q><G><S><T><D><Y><F><L><S><S><G><D><K><I><R><F><F><F><E><K><G><V><F><D><E><K><G><N><F><L><V><P><P><E><K><S><I><N><K><I><G><H><A><L... | Isoform 3 probably lacks enzyme activity.<BOP> | Q5SRE7 |
Q16611 | BAK_HUMAN | Bcl-2-like protein 7 | Homo | <M><A><S><G><Q><G><P><G><P><P><R><Q><E><C><G><E><P><A><L><P><S><A><S><E><E><Q><V><A><Q><D><T><E><E><V><F><R><S><Y><V><F><Y><R><H><Q><Q><E><Q><E><A><E><G><V><A><A><P><A><D><P><E><M><V><T><L><P><L><Q><P><S><S><T><M><G><Q><V><G><R><Q><L><A><I><I><G><D><D><I><N><R><R><Y><D><S><E><F><Q><T><M><L><Q><H><L><Q><P><T><A><E><N><A... | Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in ... | Q16611 |
P04554 | PRM2_HUMAN | Sperm protamine P3 | Homo | <M><V><R><Y><R><V><R><S><L><S><E><R><S><H><E><V><Y><R><Q><Q><L><H><G><Q><E><Q><G><H><H><G><Q><E><E><Q><G><L><S><P><E><H><V><E><V><Y><E><R><T><H><G><Q><S><H><Y><R><R><R><H><C><S><R><R><R><L><H><R><I><H><R><R><Q><H><R><S><C><R><R><R><K><R><R><S><C><R><H><R><R><R><H><R><R><G><C><R><T><R><K><R><T><C><R><R><H> | Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.<BOP> | P04554 |
Q7L311 | ARMX2_HUMAN | ARM protein lost in epithelial cancers on chromosome X 2 | Homo | <M><S><R><V><R><D><A><G><C><V><A><A><G><I><V><I><G><A><G><A><W><Y><C><V><Y><K><Y><T><R><G><R><D><Q><T><K><K><R><M><A><K><P><K><N><R><A><V><A><G><T><G><A><R><A><R><A><G><L><R><A><G><F><T><I><D><L><G><S><G><F><S><P><P><T><P><V><R><A><E><A><E><D><R><A><Q><D><E><A><S><A><L><D><T><V><G><A><E><A><V><A><P><A><A><S><S><A><E><A... | May regulate the dynamics and distribution of mitochondria in neural cells.<BOP> | Q7L311 |
P78368 | KC1G2_HUMAN | Casein kinase I isoform gamma-2 | Homo | <M><D><F><D><K><K><G><G><K><G><E><T><E><E><G><R><R><M><S><K><A><G><G><G><R><S><S><H><G><I><R><S><S><G><T><S><S><G><V><L><M><V><G><P><N><F><R><V><G><K><K><I><G><C><G><N><F><G><E><L><R><L><G><K><N><L><Y><T><N><E><Y><V><A><I><K><L><E><P><I><K><S><R><A><P><Q><L><H><L><E><Y><R><F><Y><K><Q><L><S><A><T><E><G><V><P><Q><V><Y><Y... | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and ve... | P78368 |
P20711 | DDC_HUMAN | DOPA decarboxylase | Homo | <M><N><A><S><E><F><R><R><R><G><K><E><M><V><D><Y><M><A><N><Y><M><E><G><I><E><G><R><Q><V><Y><P><D><V><E><P><G><Y><L><R><P><L><I><P><A><A><A><P><Q><E><P><D><T><F><E><D><I><I><N><D><V><E><K><I><I><M><P><G><V><T><H><W><H><S><P><Y><F><F><A><Y><F><P><T><A><S><S><Y><P><A><M><L><A><D><M><L><C><G><A><I><G><C><I><G><F><S><W><A><A... | Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.<BOP> | P20711 |
P35030 | TRY3_HUMAN | Trypsin IV | Homo | <M><C><G><P><D><D><R><C><P><A><R><W><P><G><P><G><R><A><V><K><C><G><K><G><L><A><A><A><R><P><G><R><V><E><R><G><G><A><Q><R><G><G><A><G><L><E><L><H><P><L><L><G><G><R><T><W><R><A><A><R><D><A><D><G><C><E><A><L><G><T><V><A><V><P><F><D><D><D><D><K><I><V><G><G><Y><T><C><E><E><N><S><L><P><Y><Q><V><S><L><N><S><G><S><H><F><C><G><G... | Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.<BOP> | P35030 |
Q32M88 | PGGHG_HUMAN | Acid trehalase-like protein 1 | Homo | <M><E><D><A><G><E><D><P><T><T><F><A><A><H><S><L><P><S><D><P><R><L><L><A><T><V><T><N><A><Y><L><G><T><R><V><F><H><D><T><L><H><V><S><G><V><Y><N><G><A><G><G><D><T><H><R><A><M><L><P><S><P><L><N><V><R><L><E><A><P><A><G><M><G><E><Q><L><T><E><T><F><A><L><D><T><N><T><G><S><F><L><H><T><L><E><G><P><R><F><R><A><S><Q><C><I><Y><A><H... | Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.<BOP> | Q32M88 |
O60759 | CYTIP_HUMAN | Pleckstrin homology Sec7 and coiled-coil domains-binding protein | Homo | <M><S><L><Q><R><L><L><Q><H><S><S><N><G><N><L><A><D><F><C><A><G><P><A><Y><S><S><Y><S><T><L><T><G><S><L><T><M><D><D><N><R><R><I><Q><M><L><A><D><T><V><A><T><L><P><R><G><R><K><Q><L><A><L><T><R><S><S><S><L><S><D><F><S><W><S><Q><R><K><L><V><T><V><E><K><Q><D><N><E><T><F><G><F><E><I><Q><S><Y><R><P><Q><N><Q><N><A><C><S><S><E><M... | By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.<BOP> | O60759 |
Q9Y385 | UB2J1_HUMAN | Yeast ubiquitin-conjugating enzyme UBC6 homolog E | Homo | <M><E><T><R><Y><N><L><K><S><P><A><V><K><R><L><M><K><E><A><A><E><L><K><D><P><T><D><H><Y><H><A><Q><P><L><E><D><N><L><F><E><W><H><F><T><V><R><G><P><P><D><S><D><F><D><G><G><V><Y><H><G><R><I><V><L><P><P><E><Y><P><M><K><P><P><S><I><I><L><L><T><A><N><G><R><F><E><V><G><K><K><I><C><L><S><I><S><G><H><H><P><E><T><W><Q><P><S><W><S... | (Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 .<BOP> | Q9Y385 |
P22894 | MMP8_HUMAN | PMNL collagenase | Homo | <M><F><S><L><K><T><L><P><F><L><L><L><L><H><V><Q><I><S><K><A><F><P><V><S><S><K><E><K><N><T><K><T><V><Q><D><Y><L><E><K><F><Y><Q><L><P><S><N><Q><Y><Q><S><T><R><K><N><G><T><N><V><I><V><E><K><L><K><E><M><Q><R><F><F><G><L><N><V><T><G><K><P><N><E><E><T><L><D><M><M><K><K><P><R><C><G><V><P><D><S><G><G><F><M><L><T><P><G><N><P><K... | Can degrade fibrillar type I, II, and III collagens.<BOP> | P22894 |
Q9NZI2 | KCIP1_HUMAN | Vesicle APC-binding protein | Homo | <M><G><A><V><M><G><T><F><S><S><L><Q><T><K><Q><R><R><P><S><K><D><I><A><W><W><Y><Y><Q><Y><Q><R><D><K><I><E><D><E><L><E><M><T><M><V><C><H><R><P><E><G><L><E><Q><L><E><A><Q><T><N><F><T><K><R><E><L><Q><V><L><Y><R><G><F><K><N><E><C><P><S><G><V><V><N><E><D><T><F><K><Q><I><Y><A><Q><F><F><P><H><G><D><A><S><T><Y><A><H><Y><L><F><N... | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presen... | Q9NZI2 |
P24752 | THIL_HUMAN | T2 | Homo | <M><A><V><L><A><A><L><L><R><S><G><A><R><S><R><S><P><L><L><R><R><L><V><Q><E><I><R><Y><V><E><R><S><Y><V><S><K><P><T><L><K><E><V><V><I><V><S><A><T><R><T><P><I><G><S><F><L><G><S><L><S><L><L><P><A><T><K><L><G><S><I><A><I><Q><G><A><I><E><K><A><G><I><P><K><E><E><V><K><E><A><Y><M><G><N><V><L><Q><G><G><E><G><Q><A><P><T><R><Q><A... | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA . Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two ca... | P24752 |
Q6YN16 | HSDL2_HUMAN | Short chain dehydrogenase/reductase family 13C member 1 | Homo | <M><L><P><N><T><G><R><L><A><G><C><T><V><F><I><T><G><A><S><R><G><I><G><K><A><I><A><L><K><A><A><K><D><G><A><N><I><V><I><A><A><K><T><A><Q><P><H><P><K><L><L><G><T><I><Y><T><A><A><E><E><I><E><A><V><G><G><K><A><L><P><C><I><V><D><V><R><D><E><Q><Q><I><S><A><A><V><E><K><A><I><K><K><F><G><G><I><D><I><L><V><N><N><A><S><A><I><S><L... | Has apparently no steroid dehydrogenase activity.<BOP> | Q6YN16 |
Q8NGE0 | O10AD_HUMAN | Olfactory receptor OR12-1 | Homo | <M><L><R><N><G><S><I><V><T><E><F><I><L><V><G><F><Q><Q><S><S><T><S><T><R><A><L><L><F><A><L><F><L><A><L><Y><S><L><T><M><A><M><N><G><L><I><I><F><I><T><S><W><T><D><P><K><L><N><S><P><M><Y><F><F><L><G><H><L><S><L><L><D><V><C><F><I><T><T><T><I><P><Q><M><L><I><H><L><V><V><R><D><H><I><V><S><F><V><C><C><M><T><Q><M><Y><F><V><F><C... | Odorant receptor.<BOP> | Q8NGE0 |
A0A075B6J2 | LV233_HUMAN | Probable non-functional immunoglobulin lambda variable 2-33 | Homo | <M><A><W><A><L><L><L><L><T><L><L><T><Q><G><T><G><S><W><A><Q><S><A><L><T><Q><P><P><F><V><S><G><A><P><G><Q><S><V><T><I><S><C><T><G><T><S><S><D><V><G><D><Y><D><H><V><F><W><Y><Q><K><R><L><S><T><T><S><R><L><L><I><Y><N><V><N><T><R><P><S><G><I><S><D><L><F><S><G><S><K><S><G><N><M><A><S><L><T><I><S><G><L><K><S><E><V><E><A><N><Y... | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved ... | A0A075B6J2 |
Q6JVE6 | LCN10_HUMAN | Epididymal-specific lipocalin-10 | Homo | <M><R><Q><G><L><L><V><L><A><L><V><L><V><L><V><L><V><L><A><A><G><S><Q><V><Q><E><W><Y><P><R><E><S><H><A><L><N><W><N><K><F><S><G><F><W><Y><I><L><A><T><A><T><D><A><Q><G><F><L><P><A><R><D><K><R><K><L><G><A><S><V><V><K><V><N><K><V><G><Q><L><R><V><L><L><A><F><R><R><G><Q><G><C><G><R><A><Q><P><R><H><P><G><T><S><G><H><L><W><A><S... | May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.<BOP> | Q6JVE6 |
Q15822 | ACHA2_HUMAN | Neuronal acetylcholine receptor subunit alpha-2 | Homo | <M><G><P><S><C><P><V><F><L><S><F><T><K><L><S><L><W><W><L><L><L><T><P><A><G><G><E><E><A><K><R><P><P><P><R><A><P><G><D><P><L><S><S><P><S><P><T><A><L><P><Q><G><G><S><H><T><E><T><E><D><R><L><F><K><H><L><F><R><G><Y><N><R><W><A><R><P><V><P><N><T><S><D><V><V><I><V><R><F><G><L><S><I><A><Q><L><I><D><V><D><E><K><N><Q><M><M><T><T... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | Q15822 |
Q93086 | P2RX5_HUMAN | Purinergic receptor | Homo | <M><G><Q><A><G><C><K><G><L><C><L><S><L><F><D><Y><K><T><E><K><Y><V><I><A><K><N><K><K><V><G><L><L><Y><R><L><L><Q><A><S><I><L><A><Y><L><V><V><W><V><F><L><I><K><K><G><Y><Q><D><V><D><T><S><L><Q><S><A><V><I><T><K><V><K><G><V><A><F><T><N><T><S><D><L><G><Q><R><I><W><D><V><A><D><Y><V><I><P><A><Q><G><E><N><V><F><F><V><V><T><N><L... | Receptor for ATP that acts as a ligand-gated ion channel.<BOP> | Q93086 |
P04433 | KV311_HUMAN | Ig kappa chain V-III region VG | Homo | <M><E><A><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><G><E><I><V><L><T><Q><S><P><A><T><L><S><L><S><P><G><E><R><A><T><L><S><C><R><A><S><Q><S><V><S><S><Y><L><A><W><Y><Q><Q><K><P><G><Q><A><P><R><L><L><I><Y><D><A><S><N><R><A><T><G><I><P><A><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><E><P><E><D><F><A><V><Y><Y... | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P04433 |
Q9BYQ3 | KRA93_HUMAN | Ultrahigh sulfur keratin-associated protein 9.3 | Homo | <M><T><H><C><C><S><P><C><C><Q><P><T><C><C><R><T><T><C><W><Q><P><T><T><V><T><T><C><S><S><T><P><C><C><Q><P><S><C><C><V><S><S><C><C><Q><P><C><C><H><P><T><C><C><Q><N><T><C><C><R><T><T><C><C><Q><P><I><C><V><T><S><C><C><Q><P><S><C><C><S><T><P><C><C><Q><P><T><C><C><G><S><S><C><G><Q><S><S><S><C><A><P><V><Y><C><R><R><T><C><Y><H... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q9BYQ3 |
Q99727 | TIMP4_HUMAN | Tissue inhibitor of metalloproteinases 4 | Homo | <M><P><G><S><P><R><P><A><P><S><W><V><L><L><L><R><L><L><A><L><L><R><P><P><G><L><G><E><A><C><S><C><A><P><A><H><P><Q><Q><H><I><C><H><S><A><L><V><I><R><A><K><I><S><S><E><K><V><V><P><A><S><A><D><P><A><D><T><E><K><M><L><R><Y><E><I><K><Q><I><K><M><F><K><G><F><E><K><V><K><D><V><Q><Y><I><Y><T><P><F><D><S><S><L><C><G><V><K><L><E... | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.<BOP> | Q99727 |
O75928 | PIAS2_HUMAN | Protein inhibitor of activated STAT2 | Homo | <M><A><D><F><E><E><L><R><N><M><V><S><S><F><R><V><S><E><L><Q><V><L><L><G><F><A><G><R><N><K><S><G><R><K><H><D><L><L><M><R><A><L><H><L><L><K><S><G><C><S><P><A><V><Q><I><K><I><R><E><L><Y><R><R><R><Y><P><R><T><L><E><G><L><S><D><L><S><T><I><K><S><S><V><F><S><L><D><G><G><S><S><P><V><E><P><D><L><A><V><A><G><I><H><S><L><P><S><T... | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signal... | O75928 |
O75934 | SPF27_HUMAN | Spliceosome-associated protein SPF 27 | Homo | <M><A><G><T><G><L><V><A><G><E><V><V><V><D><A><L><P><Y><F><D><Q><G><Y><E><A><P><G><V><R><E><A><A><A><A><L><V><E><E><E><T><R><R><Y><R><P><T><K><N><Y><L><S><Y><L><T><A><P><D><Y><S><A><F><E><T><D><I><M><R><N><E><F><E><R><L><A><A><R><Q><P><I><E><L><L><S><M><K><R><Y><E><L><P><A><P><S><S><G><Q><K><N><D><I><T><A><W><Q><E><C><V... | Required for pre-mRNA splicing as component of the activated spliceosome . Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex... | O75934 |
Q3LI67 | KRA63_HUMAN | Keratin-associated protein 6-3 | Homo | <M><C><G><S><Y><Y><R><N><Y><N><G><G><H><G><Y><G><C><C><G><Y><G><G><L><G><C><G><Y><G><G><C><G><Y><G><C><C><G><Y><G><G><L><G><F><G><Y><G><G><L><D><C><G><Y><G><G><L><G><C><G><Y><G><S><F><C><G><C><G><Y><R><G><L><D><C><G><Y><G><C><G><Y><G><Y><V><S><H><S><F><C><G><C><G><Y><R><C><G><S><G><Y><G><S><S><F><G><Y><Y><Y> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q3LI67 |
P0DTE0 | T2R36_HUMAN | Putative taste receptor type 2 member 36 | Homo | <M><I><C><F><L><L><I><I><L><S><I><L><V><V><F><A><F><V><L><G><N><F><S><N><G><F><I><A><L><V><N><V><I><D><W><V><K><R><Q><K><I><S><S><A><D><Q><I><L><T><A><L><V><V><S><R><V><G><L><L><W><V><I><L><L><H><W><Y><S><N><V><L><N><S><A><L><Y><S><S><E><V><I><I><F><I><S><N><A><W><A><I><I><N><H><F><S><I><W><L><A><T><S><L><S><I><F><Y><L... | Putative taste receptor which may play a role in the perception of bitterness.<BOP> | P0DTE0 |
P21217 | FUT3_HUMAN | Fucosyltransferase III | Homo | <M><D><P><L><G><A><A><K><P><Q><W><P><W><R><R><C><L><A><A><L><L><F><Q><L><L><V><A><V><C><F><F><S><Y><L><R><V><S><R><D><D><A><T><G><S><P><R><A><P><S><G><S><S><R><Q><D><T><T><P><T><R><P><T><L><L><I><L><L><W><T><W><P><F><H><I><P><V><A><L><S><R><C><S><E><M><V><P><G><T><A><D><C><H><I><T><A><D><R><K><V><Y><P><Q><A><D><T><V><I... | Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->... | P21217 |
Q9H9Q4 | NHEJ1_HUMAN | XRCC4-like factor | Homo | <M><E><E><L><E><Q><G><L><L><M><Q><P><W><A><W><L><Q><L><A><E><N><S><L><L><A><K><V><F><I><T><K><Q><G><Y><A><L><L><V><S><D><L><Q><Q><V><W><H><E><Q><V><D><T><S><V><V><S><Q><R><A><K><E><L><N><K><R><L><T><A><P><P><A><A><F><L><C><H><L><D><N><L><L><R><P><L><L><K><D><A><A><H><P><S><E><A><T><F><S><C><D><C><V><A><D><A><L><I><L><R... | DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends . Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joi... | Q9H9Q4 |
Q8IYX8 | CE57L_HUMAN | Cep57-related protein | Homo | <M><D><S><E><L><M><H><S><I><V><G><S><Y><H><K><P><P><E><R><V><F><V><P><S><F><T><Q><N><E><P><S><Q><N><C><H><P><A><N><L><E><V><T><S><P><K><I><L><H><S><P><N><S><Q><A><L><I><L><A><L><K><T><L><Q><E><K><I><H><R><L><E><L><E><R><T><Q><A><E><D><N><L><N><I><L><S><R><E><A><A><Q><Y><K><K><A><L><E><N><E><T><N><E><R><N><L><A><H><Q><E... | Centrosomal protein which may be required for microtubule attachment to centrosomes.<BOP> | Q8IYX8 |
Q86YD5 | LRAD3_HUMAN | Low-density lipoprotein receptor class A domain-containing protein 3 | Homo | <M><W><L><L><G><P><L><C><L><L><L><S><S><A><A><E><S><Q><L><L><P><G><N><N><F><T><N><E><C><N><I><P><G><N><F><M><C><S><N><G><R><C><I><P><G><A><W><Q><C><D><G><L><P><D><C><F><D><K><S><D><E><K><E><C><P><K><A><K><S><K><C><G><P><T><F><F><P><C><A><S><G><I><H><C><I><I><G><R><F><R><C><N><G><F><E><D><C><P><D><G><S><D><E><E><N><C><T... | (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.<BOP> | Q86YD5 |
Q99729 | ROAA_HUMAN | APOBEC1-binding protein 1 | Homo | <M><S><E><A><G><E><E><Q><P><M><E><T><T><G><A><T><E><N><G><H><E><A><V><P><E><A><S><R><G><R><G><W><T><G><A><A><A><G><A><G><G><A><T><A><A><P><P><S><G><N><Q><N><G><A><E><G><D><Q><I><N><A><S><K><N><E><E><D><A><G><K><M><F><V><G><G><L><S><W><D><T><S><K><K><D><L><K><D><Y><F><T><K><F><G><E><V><V><D><C><T><I><K><M><D><P><N><T><G... | Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.<BOP> | Q99729 |
Q6IEZ7 | OR2T5_HUMAN | Olfactory receptor OR1-62 | Homo | <M><A><N><I><T><R><M><A><N><H><T><G><K><L><D><F><I><L><M><G><L><F><R><R><S><K><H><P><A><L><L><S><V><V><I><F><V><V><F><L><K><A><L><S><G><N><A><V><L><I><L><L><I><H><C><D><A><H><L><H><S><P><M><Y><F><F><I><S><Q><L><S><L><M><D><M><A><Y><I><S><V><T><V><P><K><M><L><L><D><Q><V><M><G><V><N><K><V><S><A><P><E><C><G><M><Q><M><F><L... | Odorant receptor.<BOP> | Q6IEZ7 |
Q86XR8 | CEP57_HUMAN | Translokin | Homo | <M><A><A><A><S><V><S><A><A><S><G><S><H><L><S><N><S><F><A><E><P><S><R><S><N><G><S><M><V><R><H><S><S><S><P><Y><V><V><Y><P><S><D><K><P><F><L><N><S><D><L><R><R><S><P><S><K><P><T><L><A><Y><P><E><S><N><S><R><A><I><F><S><A><L><K><N><L><Q><D><K><I><R><R><L><E><L><E><R><I><Q><A><E><E><S><V><K><T><L><S><R><E><T><I><E><Y><K><K><V... | Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.<BOP> | Q86XR8 |
Q9NZH7 | IL36B_HUMAN | Interleukin-1 homolog 2 | Homo | <M><N><P><Q><R><E><A><A><P><K><S><Y><A><I><R><D><S><R><Q><M><V><W><V><L><S><G><N><S><L><I><A><A><P><L><S><R><S><I><K><P><V><T><L><H><L><I><A><C><R><D><T><E><F><S><D><K><E><K><G><N><M><V><Y><L><G><I><K><G><K><D><L><C><L><F><C><A><E><I><Q><G><K><P><T><L><Q><L><K><L><Q><G><S><Q><D><N><I><G><K><D><T><C><W><K><L><V><G><I><H... | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory respo... | Q9NZH7 |
Q9UPQ8 | DOLK_HUMAN | Transmembrane protein 15 | Homo | <M><T><R><E><C><P><S><P><A><P><G><P><G><A><P><L><S><G><S><V><L><A><E><A><A><V><V><F><A><V><V><L><S><I><H><A><T><V><W><D><R><Y><S><W><C><A><V><A><L><A><V><Q><A><F><Y><V><Q><Y><K><W><D><R><L><L><Q><Q><G><S><A><V><F><Q><F><R><M><S><A><N><S><G><L><L><P><A><S><M><V><M><P><L><L><G><L><V><M><K><E><R><C><Q><T><A><G><N><P><F><F... | Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis . Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors .<BOP> | Q9UPQ8 |
Q6DN72 | FCRL6_HUMAN | IFGP6 | Homo | <M><L><L><W><T><A><V><L><L><F><V><P><C><V><G><K><T><V><W><L><Y><L><Q><A><W><P><N><P><V><F><E><G><D><A><L><T><L><R><C><Q><G><W><K><N><T><P><L><S><Q><V><K><F><Y><R><D><G><K><F><L><H><F><S><K><E><N><Q><T><L><S><M><G><A><A><T><V><Q><S><R><G><Q><Y><S><C><S><G><Q><V><M><Y><I><P><Q><T><F><T><Q><T><S><E><T><A><M><V><Q><V><Q><E... | Acts as a MHC class II receptor . When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells . Does not act as an Fc receptor .<BOP> | Q6DN72 |
P02042 | HBD_HUMAN | Hemoglobin delta chain | Homo | <M><V><H><L><T><P><E><E><K><T><A><V><N><A><L><W><G><K><V><N><V><D><A><V><G><G><E><A><L><G><R><L><L><V><V><Y><P><W><T><Q><R><F><F><E><S><F><G><D><L><S><S><P><D><A><V><M><G><N><P><K><V><K><A><H><G><K><K><V><L><G><A><F><S><D><G><L><A><H><L><D><N><L><K><G><T><F><S><Q><L><S><E><L><H><C><D><K><L><H><V><D><P><E><N><F><R><L><L... | Involved in oxygen transport from the lung to the various peripheral tissues.<BOP> | P02042 |
O75936 | BODG_HUMAN | Gamma-butyrobetaine,2-oxoglutarate dioxygenase | Homo | <M><A><C><T><I><Q><K><A><E><A><L><D><G><A><H><L><M><Q><I><L><W><Y><D><E><E><E><S><L><Y><P><A><V><W><L><R><D><N><C><P><C><S><D><C><Y><L><D><S><A><K><A><R><K><L><L><V><E><A><L><D><V><N><I><G><I><K><G><L><I><F><D><R><K><K><V><Y><I><T><W><P><D><E><H><Y><S><E><F><Q><A><D><W><L><K><K><R><C><F><S><K><Q><A><R><A><K><L><Q><R><E... | Catalyzes the formation of L-carnitine from gamma-butyrobetaine.<BOP> | O75936 |
Q16698 | DECR_HUMAN | Short chain dehydrogenase/reductase family 18C member 1 | Homo | <M><K><L><P><A><R><V><F><F><T><L><G><S><R><L><P><C><G><L><A><P><R><R><F><F><S><Y><G><T><K><I><L><Y><Q><N><T><E><A><L><Q><S><K><F><F><S><P><L><Q><K><A><M><L><P><P><N><S><F><Q><G><K><V><A><F><I><T><G><G><G><T><G><L><G><K><G><M><T><T><L><L><S><S><L><G><A><Q><C><V><I><A><S><R><K><M><D><V><L><K><A><T><A><E><Q><I><S><S><Q><T... | Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.<BOP> | Q16698 |
Q14938 | NFIX_HUMAN | TGGCA-binding protein | Homo | <M><Y><S><P><Y><C><L><T><Q><D><E><F><H><P><F><I><E><A><L><L><P><H><V><R><A><F><S><Y><T><W><F><N><L><Q><A><R><K><R><K><Y><F><K><K><H><E><K><R><M><S><K><D><E><E><R><A><V><K><D><E><L><L><G><E><K><P><E><I><K><Q><K><W><A><S><R><L><L><A><K><L><R><K><D><I><R><P><E><F><R><E><D><F><V><L><T><I><T><G><K><K><P><P><C><C><V><L><S><N... | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.<BOP> | Q14938 |
O75794 | CD123_HUMAN | PZ32 | Homo | <M><K><K><E><H><V><L><H><C><Q><F><S><A><W><Y><P><F><F><R><G><V><T><I><K><S><V><I><L><P><L><P><Q><N><V><K><D><Y><L><L><D><D><G><T><L><V><V><S><G><R><D><D><P><P><T><H><S><Q><P><D><S><D><D><E><A><E><E><I><Q><W><S><D><D><E><N><T><A><T><L><T><A><P><E><F><P><E><F><A><T><K><V><Q><E><A><I><N><S><L><G><G><S><V><F><P><K><L><N><W... | Required for S phase entry of the cell cycle.<BOP> | O75794 |
Q9BQN1 | FA83C_HUMAN | Protein FAM83C | Homo | <M><F><G><G><P><G><P><G><V><L><G><A><Q><G><M><A><G><P><L><R><G><R><V><E><E><L><K><L><P><W><W><R><E><S><S><P><L><V><L><R><H><S><E><A><A><R><L><A><A><D><A><L><L><E><R><G><E><A><A><Y><L><R><V><I><S><E><E><R><E><L><P><F><L><S><A><L><D><V><D><Y><M><T><S><H><V><R><G><G><P><E><L><S><E><A><Q><G><Q><E><A><S><G><P><D><R><L><S><L... | May play a role in MAPK signaling.<BOP> | Q9BQN1 |
P80297 | MT1X_HUMAN | Metallothionein-IX | Homo | <M><D><P><N><C><S><C><S><P><V><G><S><C><A><C><A><G><S><C><K><C><K><E><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><V><G><C><A><K><C><A><Q><G><C><I><C><K><G><T><S><D><K><C><S><C><C><A> | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling .<BOP> | P80297 |
P51168 | SCNNB_HUMAN | SCNEB | Homo | <M><H><V><K><K><Y><L><L><K><G><L><H><R><L><Q><K><G><P><G><Y><T><Y><K><E><L><L><V><W><Y><C><D><N><T><N><T><H><G><P><K><R><I><I><C><E><G><P><K><K><K><A><M><W><F><L><L><T><L><L><F><A><A><L><V><C><W><Q><W><G><I><F><I><R><T><Y><L><S><W><E><V><S><V><S><L><S><V><G><F><K><T><M><D><F><P><A><V><T><I><C><N><A><S><P><F><K><Y><S><K... | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway su... | P51168 |
O75695 | XRP2_HUMAN | Protein XRP2 | Homo | <M><G><C><F><F><S><K><R><R><K><A><D><K><E><S><R><P><E><N><E><E><E><R><P><K><Q><Y><S><W><D><Q><R><E><K><V><D><P><K><D><Y><M><F><S><G><L><K><D><E><T><V><G><R><L><P><G><T><V><A><G><Q><Q><F><L><I><Q><D><C><E><N><C><N><I><Y><I><F><D><H><S><A><T><V><T><I><D><D><C><T><N><C><I><I><F><L><G><P><V><K><G><S><V><F><F><R><N><C><R><D... | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubul... | O75695 |
Q8N743 | KI3L3_HUMAN | Killer cell inhibitory receptor 1 | Homo | <M><S><L><M><V><V><S><M><A><C><V><G><F><F><L><L><E><G><P><W><P><H><V><G><G><Q><D><K><P><F><L><S><A><W><P><G><T><V><V><S><E><G><Q><H><V><T><L><Q><C><R><S><R><L><G><F><N><E><F><S><L><S><K><E><D><G><M><P><V><P><E><L><Y><N><R><I><F><R><N><S><F><L><M><G><P><V><T><P><A><H><A><G><T><Y><R><C><C><S><S><H><P><H><S><P><T><G><W><S... | Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.<BOP> | Q8N743 |
P43234 | CATO_HUMAN | Cathepsin O | Homo | <M><D><V><R><A><L><P><W><L><P><W><L><L><W><L><L><C><R><G><G><G><D><A><D><S><R><A><P><F><T><P><T><W><P><R><S><R><E><R><E><A><A><A><F><R><E><S><L><N><R><H><R><Y><L><N><S><L><F><P><S><E><N><S><T><A><F><Y><G><I><N><Q><F><S><Y><L><F><P><E><E><F><K><A><I><Y><L><R><S><K><P><S><K><F><P><R><Y><S><A><E><V><H><M><S><I><P><N><V><S... | Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.<BOP> | P43234 |
Q13177 | PAK2_HUMAN | C-t-PAK2 | Homo | <M><S><D><N><G><E><L><E><D><K><P><P><A><P><P><V><R><M><S><S><T><I><F><S><T><G><G><K><D><P><L><S><A><N><H><S><L><K><P><L><P><S><V><P><E><E><K><K><P><R><H><K><I><I><S><I><F><S><G><T><E><K><G><S><K><K><K><E><K><E><R><P><E><I><S><P><P><S><D><F><E><H><T><I><H><V><G><F><D><A><V><T><G><E><F><T><G><M><P><E><Q><W><A><R><L><L><Q... | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation . Acts as downstream effector of the small GTPases CDC42 and RAC1 . Activation by the binding of active CDC42 and RAC1 resul... | Q13177 |
A8MQT2 | GOG8B_HUMAN | Golgin-67 | Homo | <M><A><E><E><T><G><Q><S><K><L><A><A><A><K><K><K><F><K><E><Y><W><Q><R><N><R><P><G><V><P><A><A><A><K><R><N><T><K><A><N><G><S><S><P><E><T><A><A><S><G><G><C><H><S><S><E><A><S><S><S><A><S><S><S><L><H><A><R><Q><S><P><C><Q><E><Q><A><A><V><L><N><S><R><S><I><K><I><S><R><L><N><D><T><I><K><S><L><K><Q><Q><K><K><Q><V><E><H><Q><L><E... | May be involved in maintaining Golgi structure.<BOP> | A8MQT2 |
Q9NS68 | TNR19_HUMAN | Toxicity and JNK inducer | Homo | <M><A><L><K><V><L><L><E><Q><E><K><T><F><F><T><L><L><V><L><L><G><Y><L><S><C><K><V><T><C><E><S><G><D><C><R><Q><Q><E><F><R><D><R><S><G><N><C><V><P><C><N><Q><C><G><P><G><M><E><L><S><K><E><C><G><F><G><Y><G><E><D><A><Q><C><V><T><C><R><L><H><R><F><K><E><D><W><G><F><Q><K><C><K><P><C><L><D><C><A><V><V><N><R><F><Q><K><A><N><C><S... | Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.<BOP> | Q9NS68 |
Q6NUN0 | ACSM5_HUMAN | Acyl-CoA synthetase medium-chain family member 5 | Homo | <M><R><P><W><L><R><H><L><V><L><Q><A><L><R><N><S><R><A><F><C><G><S><H><G><K><P><A><P><L><P><V><P><Q><K><I><V><A><T><W><E><A><I><S><L><G><R><Q><L><V><P><E><Y><F><N><F><A><H><D><V><L><D><V><W><S><R><L><E><E><A><G><H><R><P><P><N><P><A><F><W><W><V><N><G><T><G><A><E><I><K><W><S><F><E><E><L><G><K><Q><S><R><K><A><A><N><V><L><G... | Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism.<BOP> | Q6NUN0 |
Q96RJ3 | TR13C_HUMAN | BLyS receptor 3 | Homo | <M><R><R><G><P><R><S><L><R><G><R><D><A><P><A><P><T><P><C><V><P><A><E><C><F><D><L><L><V><R><H><C><V><A><C><G><L><L><R><T><P><R><P><K><P><A><G><A><S><S><P><A><P><R><T><A><L><Q><P><Q><E><S><V><G><A><G><A><G><E><A><A><L><P><L><P><G><L><L><F><G><A><P><A><L><L><G><L><A><L><V><L><A><L><V><L><V><G><L><V><S><W><R><R><R><Q><R><R... | B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<BOP> | Q96RJ3 |
Q8N2G4 | LYPD1_HUMAN | Putative HeLa tumor suppressor | Homo | <M><W><V><L><G><I><A><A><T><F><C><G><L><F><L><L><P><G><F><A><L><Q><I><Q><C><Y><Q><C><E><E><F><Q><L><N><N><D><C><S><S><P><E><F><I><V><N><C><T><V><N><V><Q><D><M><C><Q><K><E><V><M><E><Q><S><A><G><I><M><Y><R><K><S><C><A><S><S><A><A><C><L><I><A><S><A><G><Y><Q><S><F><C><S><P><G><K><L><N><S><V><C><I><S><C><C><N><T><P><L><C><N... | Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their ex... | Q8N2G4 |
Q8IX04 | UEVLD_HUMAN | EV and lactate/malate dehydrogenase domain-containing protein | Homo | <M><E><F><D><C><E><G><L><R><R><L><L><G><K><Y><K><F><R><D><L><T><V><E><E><L><R><N><V><N><V><F><F><P><H><F><K><Y><S><M><D><T><Y><V><F><K><D><S><S><Q><K><D><L><L><N><F><T><G><T><I><P><V><M><Y><Q><G><N><T><Y><N><I><P><I><R><F><W><I><L><D><S><H><P><F><A><P><P><I><C><F><L><K><P><T><A><N><M><G><I><L><V><G><K><H><V><D><A><Q><G... | Possible negative regulator of polyubiquitination.<BOP> | Q8IX04 |
Q9UNM6 | PSD13_HUMAN | 26S proteasome regulatory subunit p40.5 | Homo | <M><K><D><V><P><G><F><L><Q><Q><S><Q><N><S><G><P><G><Q><P><A><V><W><H><R><L><E><E><L><Y><T><K><K><L><W><H><Q><L><T><L><Q><V><L><D><F><V><Q><D><P><C><F><A><Q><G><D><G><L><I><K><L><Y><E><N><F><I><S><E><F><E><H><R><V><N><P><L><S><L><V><E><I><I><L><H><V><V><R><Q><M><T><D><P><N><V><A><L><T><F><L><E><K><T><R><E><K><V><K><S><S... | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions ... | Q9UNM6 |
Q9BWW9 | APOL5_HUMAN | Apolipoprotein L-V | Homo | <M><P><C><G><K><Q><G><N><L><Q><V><P><G><S><K><V><L><P><G><L><G><E><G><C><K><E><M><W><L><R><K><V><I><Y><G><G><E><V><W><G><K><S><P><E><P><E><F><P><S><L><V><N><L><C><Q><S><W><K><I><N><N><L><M><S><T><V><H><S><D><E><A><G><M><L><S><Y><F><L><F><E><E><L><M><R><C><D><K><D><S><M><P><D><G><N><L><S><E><E><E><K><L><F><L><S><Y><F><P... | May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.<BOP> | Q9BWW9 |
Q8NHQ1 | CEP70_HUMAN | p10-binding protein | Homo | <M><F><P><V><A><P><K><P><Q><D><S><S><Q><P><S><D><R><L><M><T><E><K><Q><Q><E><E><A><E><W><E><S><I><N><V><L><L><M><M><H><G><L><K><P><L><S><L><V><K><R><T><D><L><K><D><L><I><I><F><D><K><Q><S><S><Q><R><M><R><Q><N><L><K><L><L><V><E><E><T><S><C><Q><Q><N><M><I><Q><E><L><I><E><T><N><Q><Q><L><R><N><E><L><Q><L><E><Q><S><R><A><A><N... | Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.<BOP> | Q8NHQ1 |
Q8TBE7 | S35G2_HUMAN | Transmembrane protein 22 | Homo | <M><D><T><S><P><S><R><K><Y><P><V><K><K><R><V><K><I><H><P><N><T><V><M><V><K><Y><T><S><H><Y><P><Q><P><G><D><D><G><Y><E><E><I><N><E><G><Y><G><N><F><M><E><E><N><P><K><K><G><L><L><S><E><M><K><K><K><G><R><A><F><F><G><T><M><D><T><L><P><P><P><T><E><D><P><M><I><N><E><I><G><Q><F><Q><S><F><A><E><K><N><I><F><Q><S><R><K><M><W><I><V... | May play a role in cell proliferation.<BOP> | Q8TBE7 |
O95665 | NTR2_HUMAN | Levocabastine-sensitive neurotensin receptor | Homo | <M><E><T><S><S><P><R><P><P><R><P><S><S><N><P><G><L><S><L><D><A><R><L><G><V><D><T><R><L><W><A><K><V><L><F><T><A><L><Y><A><L><I><W><A><L><G><A><A><G><N><A><L><S><A><H><V><V><L><K><A><R><A><G><R><A><G><R><L><R><H><H><V><L><S><L><A><L><A><G><L><L><L><L><L><V><G><V><P><V><E><L><Y><S><F><V><W><F><H><Y><P><W><V><F><G><D><L><G... | Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.<BOP> | O95665 |
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