accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q5T7P2
LCE1A_HUMAN
Late envelope protein 1
Homo
<M><S><C><Q><Q><S><Q><Q><Q><C><Q><P><P><P><K><C><T><P><K><C><P><P><K><C><P><T><P><K><C><P><P><K><C><P><P><K><C><P><P><V><S><S><C><C><S><V><S><S><G><G><C><C><G><S><S><S><G><G><G><C><S><S><G><G><G><G><C><C><L><S><H><H><R><R><H><R><S><H><R><H><R><L><Q><S><S><G><C><C><S><Q><P><S><G><G><S><S><C><C><G><G><D><S><G><Q><H><S><G><G><C><C>
Precursors of the cornified envelope of the stratum corneum.<BOP>
Q5T7P2
O75387
LAT3_HUMAN
Solute carrier family 43 member 1
Homo
<M><A><P><T><L><Q><Q><A><Y><R><R><R><W><W><M><A><C><T><A><V><L><E><N><L><F><F><S><A><V><L><L><G><W><G><S><L><L><I><I><L><K><N><E><G><F><Y><S><S><T><C><P><A><E><S><S><T><N><T><T><Q><D><E><Q><R><R><W><P><G><C><D><Q><Q><D><E><M><L><N><L><G><F><T><I><G><S><F><V><L><S><A><T><T><L><P><L><G><I><L><M><D><R><F><G><P><R><P><V><R><L><V><G><S><A><C><F><T><A><S><C><T><L><M><A><L><A><S><R><D><V><E><A><L><S><P><L><I><F><L><A><L><S><L><N><G><F><G><G><I><C><L><T><F><T><S><L><T><L><P><N><M><F><G><N><L><R><S><T><L><M><A><L><M><I><G><S><Y><A><S><S><A><I><T><F><P><G><I><K><L><I><Y><D><A><G><V><A><F><V><V><I><M><F><T><W><S><G><L><A><C><L><I><F><L><N><C><T><L><N><W><P><I><E><A><F><P><A><P><E><E><V><N><Y><T><K><K><I><K><L><S><G><L><A><L><D><H><K><V><T><G><D><L><F><Y><T><H><V><T><T><M><G><Q><R><L><S><Q><K><A><P><S><L><E><D><G><S><D><A><F><M><S><P><Q><D><V><R><G><T><S><E><N><L><P><E><R><S><V><P><L><R><K><S><L><C><S><P><T><F><L><W><S><L><L><T><M><G><M><T><Q><L><R><I><I><F><Y><M><A><A><V><N><K><M><L><E><Y><L><V><T><G><G><Q><E><H><E><T><N><E><Q><Q><Q><K><V><A><E><T><V><G><F><Y><S><S><V><F><G><A><M><Q><L><L><C><L><L><T><C><P><L><I><G><Y><I><M><D><W><R><I><K><D><C><V><D><A><P><T><Q><G><T><V><L><G><D><A><R><D><G><V><A><T><K><S><I><R><P><R><Y><C><K><I><Q><K><L><T><N><A><I><S><A><F><T><L><T><N><L><L><L><V><G><F><G><I><T><C><L><I><N><N><L><H><L><Q><F><V><T><F><V><L><H><T><I><V><R><G><F><F><H><S><A><C><G><S><L><Y><A><A><V><F><P><S><N><H><F><G><T><L><T><G><L><Q><S><L><I><S><A><V><F><A><L><L><Q><Q><P><L><F><M><A><M><V><G><P><L><K><G><E><P><F><W><V><N><L><G><L><L><L><F><S><L><L><G><F><L><L><P><S><Y><L><F><Y><Y><R><A><R><L><Q><Q><E><Y><A><A><N><G><M><G><P><L><K><V><L><S><G><S><E><V><T><A>
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.<BOP>
O75387
Q9H344
O51I2_HUMAN
Olfactory receptor OR11-38
Homo
<M><G><L><F><N><V><T><H><P><A><F><F><L><L><T><G><I><P><G><L><E><S><S><H><S><W><L><S><G><P><L><C><V><M><Y><A><V><A><L><G><G><N><T><V><I><L><Q><A><V><R><V><E><P><S><L><H><E><P><M><Y><Y><F><L><S><M><L><S><F><S><D><V><A><I><S><M><A><T><L><P><T><V><L><R><T><F><C><L><N><A><R><N><I><T><F><D><A><C><L><I><Q><M><F><L><I><H><F><F><S><M><M><E><S><G><I><L><L><A><M><S><F><D><R><Y><V><A><I><C><D><P><L><R><Y><A><T><V><L><T><T><E><V><I><A><A><M><G><L><G><A><A><A><R><S><F><I><T><L><F><P><L><P><F><L><I><K><R><L><P><I><C><R><S><N><V><L><S><H><S><Y><C><L><H><P><D><M><M><R><L><A><C><A><D><I><S><I><N><S><I><Y><G><L><F><V><L><V><S><T><F><G><M><D><L><F><F><I><F><L><S><Y><V><L><I><L><R><S><V><M><A><T><A><S><R><E><E><R><L><K><A><L><N><T><C><V><S><H><I><L><A><V><L><A><F><Y><V><P><M><I><G><V><S><T><V><H><R><F><G><K><H><V><P><C><Y><I><H><V><L><M><S><N><V><Y><L><F><V><P><P><V><L><N><P><L><I><Y><S><A><K><T><K><E><I><R><R><A><I><F><R><M><F><H><H><I><K><I>
Odorant receptor.<BOP>
Q9H344
P09455
RET1_HUMAN
Cellular retinol-binding protein I
Homo
<M><P><V><D><F><T><G><Y><W><K><M><L><V><N><E><N><F><E><E><Y><L><R><A><L><D><V><N><V><A><L><R><K><I><A><N><L><L><K><P><D><K><E><I><V><Q><D><G><D><H><M><I><I><R><T><L><S><T><F><R><N><Y><I><M><D><F><Q><V><G><K><E><F><E><E><D><L><T><G><I><D><D><R><K><C><M><T><T><V><S><W><D><G><D><K><L><Q><C><V><Q><K><G><E><K><E><G><R><G><W><T><Q><W><I><E><G><D><E><L><H><L><E><M><R><V><E><G><V><V><C><K><Q><V><F><K><K><V><Q>
Cytoplasmic retinol-binding protein . Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis .<BOP>
P09455
Q5T5A8
LCE3C_HUMAN
Small proline-rich-like epidermal differentiation complex protein 3A
Homo
<M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><P><P><S><C><P><S><P><K><C><P><P><K><S><P><A><Q><C><L><P><P><P><S><S><D><C><A><L><S><S><G><G><C><G><P><S><S><E><S><G><C><C><L><S><H><H><R><H><F><R><S><H><Q><C><R><R><Q><R><S><N><S><C><D><R><G><S><G><Q><Q><G><G><G><S><C><R><G><H><G><S><G><G><C><C>
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens .<BOP>
Q5T5A8
Q9C056
NKX62_HUMAN
Homeobox protein NK-6 homolog B
Homo
<M><D><T><N><R><P><G><A><F><V><L><S><S><A><P><L><A><A><L><H><N><M><A><E><M><K><T><S><L><F><P><Y><A><L><Q><G><P><A><G><F><K><A><P><A><L><G><G><L><G><A><Q><L><P><L><G><T><P><H><G><I><S><D><I><L><G><R><P><V><G><A><A><G><G><G><L><L><G><G><L><P><R><L><N><G><L><A><S><S><A><G><V><Y><F><G><P><A><A><A><V><A><R><G><Y><P><K><P><L><A><E><L><P><G><R><P><P><I><F><W><P><G><V><V><Q><G><A><P><W><R><D><P><R><L><A><G><P><A><P><A><G><G><V><L><D><K><D><G><K><K><K><H><S><R><P><T><F><S><G><Q><Q><I><F><A><L><E><K><T><F><E><Q><T><K><Y><L><A><G><P><E><R><A><R><L><A><Y><S><L><G><M><T><E><S><Q><V><K><V><W><F><Q><N><R><R><T><K><W><R><K><R><H><A><V><E><M><A><S><A><K><K><K><Q><D><S><D><A><E><K><L><K><V><G><G><S><D><A><E><D><D><D><E><Y><N><R><P><L><D><P><N><S><D><D><E><K><I><T><R><L><L><K><K><H><K><P><S><N><L><A><L><V><S><P><C><G><G><G><A><G><D><A><L>
Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.<BOP>
Q9C056
A0A0C4DH27
TRGV8_HUMAN
T cell receptor gamma variable 8
Homo
<M><L><L><A><L><A><L><L><L><A><F><L><P><P><A><S><Q><K><S><S><N><L><E><G><R><T><K><S><V><T><R><P><T><G><S><S><A><V><I><T><C><D><L><P><V><E><N><A><V><Y><T><H><W><Y><L><H><Q><E><G><K><A><P><Q><R><L><L><Y><Y><D><S><Y><N><S><R><V><V><L><E><S><G><I><S><R><E><K><Y><H><T><Y><A><S><T><G><K><S><L><K><F><I><L><E><N><L><I><E><R><D><S><G><V><Y><Y><C><A><T><W><D><R>
V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential
A0A0C4DH27
P16619
CL3L1_HUMAN
LD78-beta(5-70)
Homo
<M><Q><V><S><T><A><A><L><A><V><L><L><C><T><M><A><L><C><N><Q><V><L><S><A><P><L><A><A><D><T><P><T><A><C><C><F><S><Y><T><S><R><Q><I><P><Q><N><F><I><A><D><Y><F><E><T><S><S><Q><C><S><K><P><S><V><I><F><L><T><K><R><G><R><Q><V><C><A><D><P><S><E><E><W><V><Q><K><Y><V><S><D><L><E><L><S><A>
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.<BOP>
P16619
Q8TC26
TM163_HUMAN
Transmembrane protein 163
Homo
<M><E><P><A><A><G><I><Q><R><R><S><S><Q><G><P><T><V><P><P><P><P><R><G><H><A><P><P><A><A><A><P><G><P><A><P><L><S><S><P><V><R><E><P><P><Q><L><E><E><E><R><Q><V><R><I><S><E><S><G><Q><F><S><D><G><L><E><D><R><G><L><L><E><S><S><T><R><L><K><P><H><E><A><Q><N><Y><R><K><K><A><L><W><V><S><W><F><S><I><I><V><T><L><A><L><A><V><A><A><F><T><V><S><V><M><R><Y><S><A><S><A><F><G><F><A><F><D><A><I><L><D><V><L><S><S><A><I><V><L><W><R><Y><S><N><A><A><A><V><H><S><A><H><R><E><Y><I><A><C><V><I><L><G><V><I><F><L><L><S><S><I><C><I><V><V><K><A><I><H><D><L><S><T><R><L><L><P><E><V><D><D><F><L><F><S><V><S><I><L><S><G><I><L><C><S><I><L><A><V><L><K><F><M><L><G><K><V><L><T><S><R><A><L><I><T><D><G><F><N><S><L><V><G><G><V><M><G><F><S><I><L><L><S><A><E><V><F><K><H><D><S><A><V><W><Y><L><D><G><S><I><G><V><L><I><G><L><T><I><F><A><Y><G><V><K><L><L><I><D><M><V><P><R><V><R><Q><T><R><H><Y><E><M><F><E>
May bind zinc and other divalent cations and recruit them to vesicular organelles.<BOP>
Q8TC26
Q00266
METK1_HUMAN
Methionine adenosyltransferase I/III
Homo
<M><N><G><P><V><D><G><L><C><D><H><S><L><S><E><G><V><F><M><F><T><S><E><S><V><G><E><G><H><P><D><K><I><C><D><Q><I><S><D><A><V><L><D><A><H><L><K><Q><D><P><N><A><K><V><A><C><E><T><V><C><K><T><G><M><V><L><L><C><G><E><I><T><S><M><A><M><V><D><Y><Q><R><V><V><R><D><T><I><K><H><I><G><Y><D><D><S><A><K><G><F><D><F><K><T><C><N><V><L><V><A><L><E><Q><Q><S><P><D><I><A><Q><C><V><H><L><D><R><N><E><E><D><V><G><A><G><D><Q><G><L><M><F><G><Y><A><T><D><E><T><E><E><C><M><P><L><T><I><I><L><A><H><K><L><N><A><R><M><A><D><L><R><R><S><G><L><L><P><W><L><R><P><D><S><K><T><Q><V><T><V><Q><Y><M><Q><D><N><G><A><V><I><P><V><R><I><H><T><I><V><I><S><V><Q><H><N><E><D><I><T><L><E><E><M><R><R><A><L><K><E><Q><V><I><R><A><V><V><P><A><K><Y><L><D><E><D><T><V><Y><H><L><Q><P><S><G><R><F><V><I><G><G><P><Q><G><D><A><G><V><T><G><R><K><I><I><V><D><T><Y><G><G><W><G><A><H><G><G><G><A><F><S><G><K><D><Y><T><K><V><D><R><S><A><A><Y><A><A><R><W><V><A><K><S><L><V><K><A><G><L><C><R><R><V><L><V><Q><V><S><Y><A><I><G><V><A><E><P><L><S><I><S><I><F><T><Y><G><T><S><Q><K><T><E><R><E><L><L><D><V><V><H><K><N><F><D><L><R><P><G><V><I><V><R><D><L><D><L><K><K><P><I><Y><Q><K><T><A><C><Y><G><H><F><G><R><S><E><F><P><W><E><V><P><R><K><L><V><F>
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.<BOP>
Q00266
P32302
CXCR5_HUMAN
Monocyte-derived receptor 15
Homo
<M><N><Y><P><L><T><L><E><M><D><L><E><N><L><E><D><L><F><W><E><L><D><R><L><D><N><Y><N><D><T><S><L><V><E><N><H><L><C><P><A><T><E><G><P><L><M><A><S><F><K><A><V><F><V><P><V><A><Y><S><L><I><F><L><L><G><V><I><G><N><V><L><V><L><V><I><L><E><R><H><R><Q><T><R><S><S><T><E><T><F><L><F><H><L><A><V><A><D><L><L><L><V><F><I><L><P><F><A><V><A><E><G><S><V><G><W><V><L><G><T><F><L><C><K><T><V><I><A><L><H><K><V><N><F><Y><C><S><S><L><L><L><A><C><I><A><V><D><R><Y><L><A><I><V><H><A><V><H><A><Y><R><H><R><R><L><L><S><I><H><I><T><C><G><T><I><W><L><V><G><F><L><L><A><L><P><E><I><L><F><A><K><V><S><Q><G><H><H><N><N><S><L><P><R><C><T><F><S><Q><E><N><Q><A><E><T><H><A><W><F><T><S><R><F><L><Y><H><V><A><G><F><L><L><P><M><L><V><M><G><W><C><Y><V><G><V><V><H><R><L><R><Q><A><Q><R><R><P><Q><R><Q><K><A><V><R><V><A><I><L><V><T><S><I><F><F><L><C><W><S><P><Y><H><I><V><I><F><L><D><T><L><A><R><L><K><A><V><D><N><T><C><K><L><N><G><S><L><P><V><A><I><T><M><C><E><F><L><G><L><A><H><C><C><L><N><P><M><L><Y><T><F><A><G><V><K><F><R><S><D><L><S><R><L><L><T><K><L><G><C><T><G><P><A><S><L><C><Q><L><F><P><S><W><R><R><S><S><L><S><E><S><E><N><A><T><S><L><T><T><F>
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.<BOP>
P32302
O75355
ENTP3_HUMAN
HB6
Homo
<M><F><T><V><L><T><R><Q><P><C><E><Q><A><G><L><K><A><L><Y><R><T><P><T><I><I><A><L><V><V><L><L><V><S><I><V><V><L><V><S><I><T><V><I><Q><I><H><K><Q><E><V><L><P><P><G><L><K><Y><G><I><V><L><D><A><G><S><S><R><T><T><V><Y><V><Y><Q><W><P><A><E><K><E><N><N><T><G><V><V><S><Q><T><F><K><C><S><V><K><G><S><G><I><S><S><Y><G><N><N><P><Q><D><V><P><R><A><F><E><E><C><M><Q><K><V><K><G><Q><V><P><S><H><L><H><G><S><T><P><I><H><L><G><A><T><A><G><M><R><L><L><R><L><Q><N><E><T><A><A><N><E><V><L><E><S><I><Q><S><Y><F><K><S><Q><P><F><D><F><R><G><A><Q><I><I><S><G><Q><E><E><G><V><Y><G><W><I><T><A><N><Y><L><M><G><N><F><L><E><K><N><L><W><H><M><W><V><H><P><H><G><V><E><T><T><G><A><L><D><L><G><G><A><S><T><Q><I><S><F><V><A><G><E><K><M><D><L><N><T><S><D><I><M><Q><V><S><L><Y><G><Y><V><Y><T><L><Y><T><H><S><F><Q><C><Y><G><R><N><E><A><E><K><K><F><L><A><M><L><L><Q><N><S><P><T><K><N><H><L><T><N><P><C><Y><P><R><D><Y><S><I><S><F><T><M><G><H><V><F><D><S><L><C><T><V><D><Q><R><P><E><S><Y><N><P><N><D><V><I><T><F><E><G><T><G><D><P><S><L><C><K><E><K><V><A><S><I><F><D><F><K><A><C><H><D><Q><E><T><C><S><F><D><G><V><Y><Q><P><K><I><K><G><P><F><V><A><F><A><G><F><Y><Y><T><A><S><A><L><N><L><S><G><S><F><S><L><D><T><F><N><S><S><T><W><N><F><C><S><Q><N><W><S><Q><L><P><L><L><L><P><K><F><D><E><V><Y><A><R><S><Y><C><F><S><A><N><Y><I><Y><H><L><F><V><N><G><Y><K><F><T><E><E><T><W><P><Q><I><H><F><E><K><E><V><G><N><S><S><I><A><W><S><L><G><Y><M><L><S><L><T><N><Q><I><P><A><E><S><P><L><I><R><L><P><I><E><P><P><V><F><V><G><T><L><A><F><F><T><A><A><A><L><L><C><L><A><F><L><A><Y><L><C><S><A><T><R><R><K><R><H><S><E><H><A><F><D><H><A><V><D><S><D>
Has a threefold preference for the hydrolysis of ATP over ADP.<BOP>
O75355
Q7RTS9
DYM_HUMAN
Dyggve-Melchior-Clausen syndrome protein
Homo
<M><G><S><N><S><S><R><I><G><D><L><P><K><N><E><Y><L><K><K><L><S><G><T><E><S><I><S><E><N><D><P><F><W><N><Q><L><L><S><F><S><F><P><A><P><T><S><S><S><E><L><K><L><L><E><E><A><T><I><S><V><C><R><S><L><V><E><N><N><P><R><T><G><N><L><G><A><L><I><K><V><F><L><S><R><T><K><E><L><K><L><S><A><E><C><Q><N><H><I><F><I><W><Q><T><H><N><A><L><F><I><I><C><C><L><L><K><V><F><I><C><Q><M><S><E><E><E><L><Q><L><H><F><T><Y><E><E><K><S><P><G><N><Y><S><S><D><S><E><D><L><L><E><E><L><L><C><C><L><M><Q><L><I><T><D><I><P><L><L><D><I><T><Y><E><I><S><V><E><A><I><S><T><M><V><V><F><L><S><C><Q><L><F><H><K><E><V><L><R><Q><S><I><S><H><K><Y><L><M><R><G><P><C><L><P><Y><T><S><K><L><V><K><T><L><L><Y><N><F><I><R><Q><E><K><P><P><P><P><G><A><H><V><F><P><Q><Q><S><D><G><G><G><L><L><Y><G><L><A><S><G><V><A><T><G><L><W><T><V><F><T><L><G><G><V><G><S><K><A><A><A><S><P><E><L><S><S><P><L><A><N><Q><S><L><L><L><L><L><V><L><A><N><L><T><D><A><S><D><A><P><N><P><Y><R><Q><A><I><M><S><F><K><N><T><Q><D><S><S><P><F><P><S><S><I><P><H><A><F><Q><I><N><F><N><S><L><Y><T><A><L><C><E><Q><Q><T><S><D><Q><A><T><L><L><L><Y><T><L><L><H><Q><N><S><N><I><R><T><Y><M><L><A><R><T><D><M><E><N><L><V><L><P><I><L><E><I><L><Y><H><V><E><E><R><N><S><H><H><V><Y><M><A><L><I><I><L><L><I><L><T><E><D><D><G><F><N><R><S><I><H><E><V><I><L><K><N><I><T><W><Y><S><E><R><V><L><T><E><I><S><L><G><S><L><L><I><L><V><V><I><R><T><I><Q><Y><N><M><T><R><T><R><D><K><Y><L><H><T><N><C><L><A><A><L><A><N><M><S><A><Q><F><R><S><L><H><Q><Y><A><A><Q><R><I><I><S><L><F><S><L><L><S><K><K><H><N><K><V><L><E><Q><A><T><Q><S><L><R><G><S><L><S><S><N><D><V><P><L><P><D><Y><A><Q><D><L><N><V><I><E><E><V><I><R><M><M><L><E><I><I><N><S><C><L><T><N><S><L><H><H><N><P><N><L><V><Y><A><L><L><Y><K><R><D><L><F><E><Q><F><R><T><H><P><S><F><Q><D><I><M><Q><N><I><D><L><V><I><S><F><F><S><S><R><L><L><Q><A><G><A><E><L><S><V><E><R><V><L><E><I><I><K><Q><G><V><V><A><L><P><K><D><R><L><K><K><F><P><E><L><K><F><K><Y><V><E><E><E><Q><P><E><E><F><F><I><P><Y><V><W><S><L><V><Y><N><S><A><V><G><L><Y><W><N><P><Q><D><I><Q><L><F><T><M><D><S><D>
Necessary for correct organization of Golgi apparatus. Involved in bone development.<BOP>
Q7RTS9
Q9NRH1
YAE1_HUMAN
Yae1 domain-containing protein 1
Homo
<M><S><W><V><Q><A><A><S><L><I><Q><G><P><G><D><K><G><D><V><F><D><E><E><A><D><E><S><L><L><A><Q><R><E><W><Q><S><N><M><Q><R><R><V><K><E><G><Y><R><D><G><I><D><A><G><K><A><V><T><L><Q><Q><G><F><N><Q><G><Y><K><K><G><A><E><V><I><L><N><Y><G><R><L><R><G><T><L><S><A><L><L><S><W><C><H><L><H><N><N><N><S><T><L><I><N><K><I><N><N><L><L><D><A><V><G><Q><C><E><E><Y><V><L><K><H><L><K><S><I><T><P><P><S><H><V><V><D><L><L><D><S><I><E><D><M><D><L><C><H><V><V><P><A><E><K><K><I><D><E><A><K><D><E><R><L><C><E><N><N><A><E><F><N><K><N><C><S><K><S><H><S><G><I><D><C><S><Y><V><E><C><C><R><T><Q><E><H><A><H><S><E><N><P><S><P><T><W><I><L><E><Q><T><A><S><L><V><K><Q><L><G><L><S><V><D><V><L><Q><H><L><K><Q><L>
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery . May be required for biogenesis of the large ribosomal subunit and initiation of translation .<BOP>
Q9NRH1
Q96S16
JMJD8_HUMAN
Jumonji domain-containing protein 8
Homo
<M><A><P><A><S><R><L><L><A><L><W><A><L><A><A><V><A><L><P><G><S><G><A><E><G><D><G><G><W><R><P><G><G><P><G><A><V><A><E><E><E><R><C><T><V><E><R><R><A><D><L><T><Y><A><E><F><V><Q><Q><Y><A><F><V><R><P><V><I><L><Q><G><L><T><D><N><S><R><F><R><A><L><C><S><R><D><R><L><L><A><S><F><G><D><R><V><V><R><L><S><T><A><N><T><Y><S><Y><H><K><V><D><L><P><F><Q><E><Y><V><E><Q><L><L><H><P><Q><D><P><T><S><L><G><N><D><T><L><Y><F><F><G><D><N><N><F><T><E><W><A><S><L><F><R><H><Y><S><P><P><P><F><G><L><L><G><T><A><P><A><Y><S><F><G><I><A><G><A><G><S><G><V><P><F><H><W><H><G><P><G><Y><S><E><V><I><Y><G><R><K><R><W><F><L><Y><P><P><E><K><T><P><E><F><H><P><N><K><T><T><L><A><W><L><R><D><T><Y><P><A><L><P><P><S><A><R><P><L><E><C><T><I><R><A><G><E><V><L><Y><F><P><D><R><W><W><H><A><T><L><N><L><D><T><S><V><F><I><S><T><F><L><G>
Functions as a positive regulator of TNF-induced NF-kappa-B signaling . Regulates angiogenesis and cellular metabolism through interaction with PKM .<BOP>
Q96S16
Q9NVH1
DJC11_HUMAN
DnaJ homolog subfamily C member 11
Homo
<M><A><T><A><L><S><E><E><E><L><D><N><E><D><Y><Y><S><L><L><N><V><R><R><E><A><S><S><E><E><L><K><A><A><Y><R><R><L><C><M><L><Y><H><P><D><K><H><R><D><P><E><L><K><S><Q><A><E><R><L><F><N><L><V><H><Q><A><Y><E><V><L><S><D><P><Q><T><R><A><I><Y><D><I><Y><G><K><R><G><L><E><M><E><G><W><E><V><V><E><R><R><R><T><P><A><E><I><R><E><E><F><E><R><L><Q><R><E><R><E><E><R><R><L><Q><Q><R><T><N><P><K><G><T><I><S><V><G><V><D><A><T><D><L><F><D><R><Y><D><E><E><Y><E><D><V><S><G><S><S><F><P><Q><I><E><I><N><K><M><H><I><S><Q><S><I><E><A><P><L><T><A><T><D><T><A><I><L><S><G><S><L><S><T><Q><N><G><N><G><G><G><S><I><N><F><A><L><R><R><V><T><S><A><K><G><W><G><E><L><E><F><G><A><G><D><L><Q><G><P><L><F><G><L><K><L><F><R><N><L><T><P><R><C><F><V><T><T><N><C><A><L><Q><F><S><S><R><G><I><R><P><G><L><T><T><V><L><A><R><N><L><D><K><N><T><V><G><Y><L><Q><W><R><W><G><I><Q><S><A><M><N><T><S><I><V><R><D><T><K><T><S><H><F><T><V><A><L><Q><L><G><I><P><H><S><F><A><L><I><S><Y><Q><H><K><F><Q><D><D><D><Q><T><R><V><K><G><S><L><K><A><G><F><F><G><T><V><V><E><Y><G><A><E><R><K><I><S><R><H><S><V><L><G><A><A><V><S><V><G><V><P><Q><G><V><S><L><K><V><K><L><N><R><A><S><Q><T><Y><F><F><P><I><H><L><T><D><Q><L><L><P><S><A><M><F><Y><A><T><V><G><P><L><V><V><Y><F><A><M><H><R><L><I><I><K><P><Y><L><R><A><Q><K><E><K><E><L><E><K><Q><R><E><S><A><A><T><D><V><L><Q><K><K><Q><E><A><E><S><A><V><R><L><M><Q><E><S><V><R><R><I><I><E><A><E><E><S><R><M><G><L><I><I><V><N><A><W><Y><G><K><F><V><N><D><K><S><R><K><S><E><K><V><K><V><I><D><V><T><V><P><L><Q><C><L><V><K><D><S><K><L><I><L><T><E><A><S><K><A><G><L><P><G><F><Y><D><P><C><V><G><E><E><K><N><L><K><V><L><Y><Q><F><R><G><V><L><H><Q><V><M><V><L><D><S><E><A><L><R><I><P><K><Q><S><H><R><I><D><T><D><G>
Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.<BOP>
Q9NVH1
P13473
LAMP2_HUMAN
LGP-96
Homo
<M><V><C><F><R><L><F><P><V><P><G><S><G><L><V><L><V><C><L><V><L><G><A><V><R><S><Y><A><L><E><L><N><L><T><D><S><E><N><A><T><C><L><Y><A><K><W><Q><M><N><F><T><V><R><Y><E><T><T><N><K><T><Y><K><T><V><T><I><S><D><H><G><T><V><T><Y><N><G><S><I><C><G><D><D><Q><N><G><P><K><I><A><V><Q><F><G><P><G><F><S><W><I><A><N><F><T><K><A><A><S><T><Y><S><I><D><S><V><S><F><S><Y><N><T><G><D><N><T><T><F><P><D><A><E><D><K><G><I><L><T><V><D><E><L><L><A><I><R><I><P><L><N><D><L><F><R><C><N><S><L><S><T><L><E><K><N><D><V><V><Q><H><Y><W><D><V><L><V><Q><A><F><V><Q><N><G><T><V><S><T><N><E><F><L><C><D><K><D><K><T><S><T><V><A><P><T><I><H><T><T><V><P><S><P><T><T><T><P><T><P><K><E><K><P><E><A><G><T><Y><S><V><N><N><G><N><D><T><C><L><L><A><T><M><G><L><Q><L><N><I><T><Q><D><K><V><A><S><V><I><N><I><N><P><N><T><T><H><S><T><G><S><C><R><S><H><T><A><L><L><R><L><N><S><S><T><I><K><Y><L><D><F><V><F><A><V><K><N><E><N><R><F><Y><L><K><E><V><N><I><S><M><Y><L><V><N><G><S><V><F><S><I><A><N><N><N><L><S><Y><W><D><A><P><L><G><S><S><Y><M><C><N><K><E><Q><T><V><S><V><S><G><A><F><Q><I><N><T><F><D><L><R><V><Q><P><F><N><V><T><Q><G><K><Y><S><T><A><Q><D><C><S><A><D><D><D><N><F><L><V><P><I><A><V><G><A><A><L><A><G><V><L><I><L><V><L><L><A><Y><F><I><G><L><K><H><H><H><A><G><Y><E><Q><F>
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.<BOP>
P13473
B4DX44
ZN736_HUMAN
Zinc finger protein 736
Homo
<M><G><V><L><T><F><R><D><V><A><V><E><F><S><P><E><E><W><E><C><L><D><S><A><Q><Q><R><L><Y><R><D><V><M><L><E><N><Y><G><N><L><V><S><L><G><L><A><I><F><K><P><D><L><M><T><C><L><E><Q><R><K><E><P><W><K><V><K><R><Q><E><A><V><A><K><H><P><A><G><S><F><H><F><T><A><E><I><L><P><D><H><D><I><K><D><S><F><Q><K><V><I><L><R><K><Y><G><S><C><D><L><N><N><L><H><L><K><K><D><Y><Q><S><V><G><N><C><K><G><Q><K><S><S><Y><N><G><L><H><Q><C><L><S><A><T><H><S><K><T><C><Q><C><N><K><C><G><R><G><F><Q><L><C><S><I><F><T><E><H><K><D><I><F><S><R><E><K><C><H><K><C><E><E><C><G><K><D><C><R><L><F><S><D><F><T><R><H><K><K><I><H><T><V><E><R><C><Y><K><C><E><E><C><G><K><A><F><K><K><F><S><N><L><T><E><H><K><R><V><H><T><G><E><K><P><Y><K><C><E><G><C><G><K><T><F><T><C><S><S><T><L><V><K><H><K><R><N><H><T><G><D><R><P><Y><K><C><E><E><C><G><K><A><F><K><C><F><S><D><L><T><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><N><K><A><Y><R><W><F><S><D><L><A><K><H><K><I><I><H><T><G><D><K><P><Y><T><C><N><E><C><G><K><A><F><K><W><F><S><A><L><S><K><H><K><R><I><H><T><G><E><K><P><Y><I><C><E><E><C><G><K><A><F><T><R><S><S><T><L><F><N><H><K><R><I><H><M><E><E><R><P><Y><K><C><E><E><C><S><K><T><F><K><C><F><S><D><L><T><N><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><S><S><W><F><S><H><L><I><R><H><K><R><I><H><T><R><E><K><L><H><K><C>
May be involved in transcriptional regulation.<BOP>
B4DX44
Q9UJK0
TSR3_HUMAN
20S S rRNA accumulation protein 3 homolog
Homo
<M><G><R><R><R><A><A><R><G><P><G><A><E><G><G><R><P><R><H><L><P><T><R><S><L><E><A><F><A><E><E><V><G><A><A><L><Q><A><S><V><E><P><G><A><A><D><G><E><G><G><P><G><P><A><A><L><P><C><T><L><A><M><W><E><L><G><H><C><D><P><R><R><C><T><G><R><K><L><A><R><L><G><L><V><R><C><L><R><L><G><H><R><F><G><G><L><V><L><S><P><V><G><K><Q><Y><A><S><P><A><D><R><Q><L><V><A><Q><S><G><V><A><V><I><D><C><S><W><A><R><L><D><E><T><P><F><G><K><M><R><G><S><H><L><R><L><L><P><Y><L><V><A><A><N><P><V><N><Y><G><R><P><Y><R><L><S><C><V><E><A><F><A><A><T><F><C><I><V><G><F><P><D><L><A><V><I><L><L><R><K><F><K><W><G><K><G><F><L><D><L><N><R><Q><L><L><D><K><Y><A><A><C><G><S><P><E><E><V><L><Q><A><E><Q><E><F><L><A><N><A><K><E><S><P><Q><E><E><E><I><D><P><F><D><V><D><S><G><R><E><F><G><N><P><N><R><P><V><A><S><T><R><L><P><S><D><T><D><D><S><D><A><S><E><D><P><G><P><G><A><E><R><G><G><A><S><S><S><C><C><E><E><E><Q><T><Q><G><R><G><A><E><A><R><A><P><A><E><V><W><K><G><I><K><K><R><Q><R><D>
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA (Probable). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (Probable).<BOP>
Q9UJK0
P17031
ZNF26_HUMAN
Zinc finger protein KOX20
Homo
<M><A><T><S><F><R><T><A><S><C><W><G><L><L><S><F><K><D><I><S><M><E><F><T><W><D><E><W><Q><L><L><D><S><T><Q><K><Y><L><Y><R><D><V><I><L><E><N><Y><H><N><L><I><S><V><G><Y><H><G><T><K><P><D><L><I><F><K><L><E><Q><G><E><D><P><W><I><I><N><A><K><I><S><R><Q><S><C><P><D><G><W><E><E><W><Y><Q><N><N><Q><D><E><L><E><S><I><E><R><S><Y><A><C><S><V><L><G><R><L><N><L><S><K><T><H><D><S><S><R><Q><R><L><Y><N><T><R><G><K><S><L><T><Q><N><S><A><P><S><R><S><Y><L><R><K><N><P><D><K><F><H><G><Y><E><E><P><Y><F><L><K><H><Q><R><A><H><S><I><E><K><N><C><V><C><S><E><C><G><K><A><F><R><C><K><S><Q><L><I><V><H><L><R><I><H><T><G><E><R><P><Y><E><C><S><K><C><E><R><A><F><S><A><K><S><N><L><N><A><H><Q><R><V><H><T><G><E><K><P><Y><S><C><S><E><C><E><K><V><F><S><F><R><S><Q><L><I><V><H><Q><E><I><H><T><G><G><K><P><Y><G><C><S><E><C><G><K><A><Y><S><W><K><S><Q><L><L><L><H><Q><R><S><H><T><G><V><K><P><Y><E><C><S><E><C><G><K><A><F><S><L><K><S><P><F><V><V><H><Q><R><T><H><T><G><V><K><P><H><K><C><S><E><C><G><K><A><F><R><S><K><S><Y><L><L><V><H><I><R><M><H><T><G><E><K><P><Y><Q><C><S><D><C><G><K><A><F><N><M><K><T><Q><L><I><V><H><Q><G><V><H><T><G><N><N><P><Y><Q><C><G><E><C><G><K><A><F><G><R><K><E><Q><L><T><A><H><L><R><A><H><A><G><E><K><P><Y><G><C><S><E><C><G><K><A><F><S><S><K><S><Y><L><V><I><H><R><R><T><H><T><G><E><R><P><Y><E><C><S><L><C><E><R><A><F><C><G><K><S><Q><L><I><I><H><Q><R><T><H><S><T><E><K><P><Y><E><C><N><E><C><E><K><A><Y><P><R><K><A><S><L><Q><I><H><Q><K><T><H><S><G><E><K><P><F><K><C><S><E><C><G><K><A><F><T><Q><K><S><S><L><S><E><H><Q><R><V><H><T><G><E><K><P><W><K><C><S><E><C><G><K><S><F><C><W><N><S><G><L><R><I><H><R><K><T><H><K>
May be involved in transcriptional regulation.<BOP>
P17031
Q8TAM1
BBS10_HUMAN
Bardet-Biedl syndrome 10 protein
Homo
<M><L><S><S><M><A><A><A><G><S><V><K><A><A><L><Q><V><A><E><V><L><E><A><I><V><S><C><C><V><G><P><E><G><R><Q><V><L><C><T><K><P><T><G><E><V><L><L><S><R><N><G><G><R><L><L><E><A><L><H><L><E><H><P><I><A><R><M><I><V><D><C><V><S><S><H><L><K><K><T><G><D><G><A><K><T><F><I><I><F><L><C><H><L><L><R><G><L><H><A><I><T><D><R><E><K><D><P><L><M><C><E><N><I><Q><T><H><G><R><H><W><K><N><C><S><R><W><K><F><I><S><Q><A><L><L><T><F><Q><T><Q><I><L><D><G><I><M><D><Q><Y><L><S><R><H><F><L><S><I><F><S><S><A><K><E><R><T><L><C><R><S><S><L><E><L><L><L><E><A><Y><F><C><G><R><V><G><R><N><N><H><K><F><I><S><Q><L><M><C><D><Y><F><F><K><C><M><T><C><K><S><G><I><G><V><F><E><L><V><D><D><H><F><V><E><L><N><V><G><V><T><G><L><P><V><S><D><S><R><I><I><A><G><L><V><L><Q><K><D><F><S><V><Y><R><P><A><D><G><D><M><R><M><V><I><V><T><E><T><I><Q><P><L><F><S><T><S><G><S><E><F><I><L><N><S><E><A><Q><F><Q><T><S><Q><F><W><I><M><E><K><T><K><A><I><M><K><H><L><H><S><Q><N><V><K><L><L><I><S><S><V><K><Q><P><D><L><V><S><Y><Y><A><G><V><N><G><I><S><V><V><E><C><L><S><S><E><E><V><S><L><I><R><R><I><I><G><L><S><P><F><V><P><P><Q><A><F><S><Q><C><E><I><P><N><T><A><L><V><K><F><C><K><P><L><I><L><R><S><K><R><Y><V><H><L><G><L><I><S><T><C><A><F><I><P><H><S><I><V><L><C><G><P><V><H><G><L><I><E><Q><H><E><D><A><L><H><G><A><L><K><M><L><R><Q><L><F><K><D><L><D><L><N><Y><M><T><Q><T><N><D><Q><N><G><T><S><S><L><F><I><Y><K><N><S><G><E><S><Y><Q><A><P><D><P><G><N><G><S><I><Q><R><P><Y><Q><D><T><V><A><E><N><K><D><A><L><E><K><T><Q><T><Y><L><K><V><H><S><N><L><V><I><P><D><V><E><L><E><T><Y><I><P><Y><S><T><P><T><L><T><P><T><D><T><F><Q><T><V><E><T><L><T><C><L><S><L><E><R><N><R><L><T><D><Y><Y><E><P><L><L><K><N><N><S><T><A><Y><S><T><R><G><N><R><I><E><I><S><Y><E><N><L><Q><V><T><N><I><T><R><K><G><S><M><L><P><V><S><C><K><L><P><N><M><G><T><S><Q><S><Y><L><S><S><S><M><P><A><G><C><V><L><P><V><G><G><N><F><E><I><L><L><H><Y><Y><L><L><N><Y><A><K><K><C><H><Q><S><E><E><T><M><V><S><M><I><I><A><N><A><L><L><G><I><P><K><V><L><Y><K><S><K><T><G><K><Y><S><F><P><H><T><Y><I><R><A><V><H><A><L><Q><T><N><Q><P><L><V><S><S><Q><T><G><L><E><S><V><M><G><K><Y><Q><L><L><T><S><V><L><Q><C><L><T><K><I><L><T><I><D><M><V><I><T><V><K><R><H><P><Q><K><V><H><N><Q><D><S><E><D><E><L>
Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis . Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . Involved in adipogenic differentiation .<BOP>
Q8TAM1
Q8NDH3
PEPL1_HUMAN
Aminopeptidase-like 1
Homo
<M><A><N><V><G><L><Q><F><Q><A><S><A><G><D><S><D><P><Q><S><R><P><L><L><L><L><G><Q><L><H><H><L><H><R><V><P><W><S><H><V><R><G><K><L><Q><P><R><V><T><E><E><L><W><Q><A><A><L><S><T><L><N><P><N><P><T><D><S><C><P><L><Y><L><N><Y><A><T><V><A><A><L><P><C><R><V><S><R><H><N><S><P><S><A><A><H><F><I><T><R><L><V><R><T><C><L><P><P><G><A><H><R><C><I><V><M><V><C><E><Q><P><E><V><F><A><S><A><C><A><L><A><R><A><F><P><L><F><T><H><R><S><G><A><S><R><R><L><E><K><K><T><V><T><V><E><F><F><L><V><G><Q><D><N><G><P><V><E><V><S><T><L><Q><C><L><A><N><A><T><D><G><V><R><L><A><A><R><I><V><D><T><P><C><N><E><M><N><T><D><T><F><L><E><E><I><N><K><V><G><K><E><L><G><I><I><P><T><I><I><R><D><E><E><L><K><T><R><G><F><G><G><I><Y><G><V><G><K><A><A><L><H><P><P><A><L><A><V><L><S><H><T><P><D><G><A><T><Q><T><I><A><W><V><G><K><G><I><V><Y><D><T><G><G><L><S><I><K><G><K><T><T><M><P><G><M><K><R><D><C><G><G><A><A><A><V><L><G><A><F><R><A><A><I><K><Q><G><F><K><D><N><L><H><A><V><F><C><L><A><E><N><S><V><G><P><N><A><T><R><P><D><D><I><H><L><L><Y><S><G><K><T><V><E><I><N><N><T><D><A><E><G><R><L><V><L><A><D><G><V><S><Y><A><C><K><D><L><G><A><D><I><I><L><D><M><A><T><L><T><G><A><Q><G><I><A><T><G><K><Y><H><A><A><V><L><T><N><S><A><E><W><E><A><A><C><V><K><A><G><R><K><C><G><D><L><V><H><P><L><V><Y><C><P><E><L><H><F><S><E><F><T><S><A><V><A><D><M><K><N><S><V><A><D><R><D><N><S><P><S><S><C><A><G><L><F><I><A><S><H><I><G><F><D><W><P><G><V><W><V><H><L><D><I><A><A><P><V><H><A><G><E><R><A><T><G><F><G><V><A><L><L><L><A><L><F><G><R><A><S><E><D><P><L><L><N><L><V><S><P><L><G><C><E><V><D><V><E><E><G><D><L><G><R><D><S><K><R><R><R><L><V>
Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.<BOP>
Q8NDH3
Q15382
RHEB_HUMAN
Ras homolog enriched in brain
Homo
<M><P><Q><S><K><S><R><K><I><A><I><L><G><Y><R><S><V><G><K><S><S><L><T><I><Q><F><V><E><G><Q><F><V><D><S><Y><D><P><T><I><E><N><T><F><T><K><L><I><T><V><N><G><Q><E><Y><H><L><Q><L><V><D><T><A><G><Q><D><E><Y><S><I><F><P><Q><T><Y><S><I><D><I><N><G><Y><I><L><V><Y><S><V><T><S><I><K><S><F><E><V><I><K><V><I><H><G><K><L><L><D><M><V><G><K><V><Q><I><P><I><M><L><V><G><N><K><K><D><L><H><M><E><R><V><I><S><Y><E><E><G><K><A><L><A><E><S><W><N><A><A><F><L><E><S><S><A><K><E><N><Q><T><A><V><D><V><F><R><R><I><I><L><E><A><E><K><M><D><G><A><A><S><Q><G><K><S><S><C><S><V><M>
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.<BOP>
Q15382
Q9Y4P1
ATG4B_HUMAN
Autophagy-related protein 4 homolog B
Homo
<M><D><A><A><T><L><T><Y><D><T><L><R><F><A><E><F><E><D><F><P><E><T><S><E><P><V><W><I><L><G><R><K><Y><S><I><F><T><E><K><D><E><I><L><S><D><V><A><S><R><L><W><F><T><Y><R><K><N><F><P><A><I><G><G><T><G><P><T><S><D><T><G><W><G><C><M><L><R><C><G><Q><M><I><F><A><Q><A><L><V><C><R><H><L><G><R><D><W><R><W><T><Q><R><K><R><Q><P><D><S><Y><F><S><V><L><N><A><F><I><D><R><K><D><S><Y><Y><S><I><H><Q><I><A><Q><M><G><V><G><E><G><K><S><I><G><Q><W><Y><G><P><N><T><V><A><Q><V><L><K><K><L><A><V><F><D><T><W><S><S><L><A><V><H><I><A><M><D><N><T><V><V><M><E><E><I><R><R><L><C><R><T><S><V><P><C><A><G><A><T><A><F><P><A><D><S><D><R><H><C><N><G><F><P><A><G><A><E><V><T><N><R><P><S><P><W><R><P><L><V><L><L><I><P><L><R><L><G><L><T><D><I><N><E><A><Y><V><E><T><L><K><H><C><F><M><M><P><Q><S><L><G><V><I><G><G><K><P><N><S><A><H><Y><F><I><G><Y><V><G><E><E><L><I><Y><L><D><P><H><T><T><Q><P><A><V><E><P><T><D><G><C><F><I><P><D><E><S><F><H><C><Q><H><P><P><C><R><M><S><I><A><E><L><D><P><S><I><A><V><G><F><F><C><K><T><E><D><D><F><N><D><W><C><Q><Q><V><K><K><L><S><L><L><G><G><A><L><P><M><F><E><L><V><E><L><Q><P><S><H><L><A><C><P><D><V><L><N><L><S><L><D><S><S><D><V><E><R><L><E><R><F><F><D><S><E><D><E><D><F><E><I><L><S><L>
Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins . Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy . The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine . Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy . Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 . In addition to the protease activity, also mediates delipidation of ATG8 family proteins
Q9Y4P1
P52292
IMA1_HUMAN
SRP1-alpha
Homo
<M><S><T><N><E><N><A><N><T><P><A><A><R><L><H><R><F><K><N><K><G><K><D><S><T><E><M><R><R><R><R><I><E><V><N><V><E><L><R><K><A><K><K><D><D><Q><M><L><K><R><R><N><V><S><S><F><P><D><D><A><T><S><P><L><Q><E><N><R><N><N><Q><G><T><V><N><W><S><V><D><D><I><V><K><G><I><N><S><S><N><V><E><N><Q><L><Q><A><T><Q><A><A><R><K><L><L><S><R><E><K><Q><P><P><I><D><N><I><I><R><A><G><L><I><P><K><F><V><S><F><L><G><R><T><D><C><S><P><I><Q><F><E><S><A><W><A><L><T><N><I><A><S><G><T><S><E><Q><T><K><A><V><V><D><G><G><A><I><P><A><F><I><S><L><L><A><S><P><H><A><H><I><S><E><Q><A><V><W><A><L><G><N><I><A><G><D><G><S><V><F><R><D><L><V><I><K><Y><G><A><V><D><P><L><L><A><L><L><A><V><P><D><M><S><S><L><A><C><G><Y><L><R><N><L><T><W><T><L><S><N><L><C><R><N><K><N><P><A><P><P><I><D><A><V><E><Q><I><L><P><T><L><V><R><L><L><H><H><D><D><P><E><V><L><A><D><T><C><W><A><I><S><Y><L><T><D><G><P><N><E><R><I><G><M><V><V><K><T><G><V><V><P><Q><L><V><K><L><L><G><A><S><E><L><P><I><V><T><P><A><L><R><A><I><G><N><I><V><T><G><T><D><E><Q><T><Q><V><V><I><D><A><G><A><L><A><V><F><P><S><L><L><T><N><P><K><T><N><I><Q><K><E><A><T><W><T><M><S><N><I><T><A><G><R><Q><D><Q><I><Q><Q><V><V><N><H><G><L><V><P><F><L><V><S><V><L><S><K><A><D><F><K><T><Q><K><E><A><V><W><A><V><T><N><Y><T><S><G><G><T><V><E><Q><I><V><Y><L><V><H><C><G><I><I><E><P><L><M><N><L><L><T><A><K><D><T><K><I><I><L><V><I><L><D><A><I><S><N><I><F><Q><A><A><E><K><L><G><E><T><E><K><L><S><I><M><I><E><E><C><G><G><L><D><K><I><E><A><L><Q><N><H><E><N><E><S><V><Y><K><A><S><L><S><L><I><E><K><Y><F><S><V><E><E><E><E><D><Q><N><V><V><P><E><T><T><S><E><G><Y><T><F><Q><V><Q><D><G><A><P><G><T><F><N><F>
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.<BOP>
P52292
Q15102
PA1B3_HUMAN
PAF-AH subunit gamma
Homo
<M><S><G><E><E><N><P><A><S><K><P><T><P><V><Q><D><V><Q><G><D><G><R><W><M><S><L><H><H><R><F><V><A><D><S><K><D><K><E><P><E><V><V><F><I><G><D><S><L><V><Q><L><M><H><Q><C><E><I><W><R><E><L><F><S><P><L><H><A><L><N><F><G><I><G><G><D><G><T><Q><H><V><L><W><R><L><E><N><G><E><L><E><H><I><R><P><K><I><V><V><V><W><V><G><T><N><N><H><G><H><T><A><E><Q><V><T><G><G><I><K><A><I><V><Q><L><V><N><E><R><Q><P><Q><A><R><V><V><V><L><G><L><L><P><R><G><Q><H><P><N><P><L><R><E><K><N><R><Q><V><N><E><L><V><R><A><A><L><A><G><H><P><R><A><H><F><L><D><A><D><P><G><F><V><H><S><D><G><T><I><S><H><H><D><M><Y><D><Y><L><H><L><S><R><L><G><Y><T><P><V><C><R><A><L><H><S><L><L><L><R><L><L><A><Q><D><Q><G><Q><G><A><P><L><L><E><P><A><P>
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.<BOP>
Q15102
Q13156
RFA4_HUMAN
Replication factor A protein 4
Homo
<M><S><K><S><G><F><G><S><Y><G><S><I><S><A><A><D><G><A><S><G><G><S><D><Q><L><C><E><R><D><A><T><P><A><I><K><T><Q><R><P><K><V><R><I><Q><D><V><V><P><C><N><V><N><Q><L><L><S><S><T><V><F><D><P><V><F><K><V><R><G><I><I><V><S><Q><V><S><I><V><G><V><I><R><G><A><E><K><A><S><N><H><I><C><Y><K><I><D><D><M><T><A><K><P><I><E><A><R><Q><W><F><G><R><E><K><V><K><Q><V><T><P><L><S><V><G><V><Y><V><K><V><F><G><I><L><K><C><P><T><G><T><K><S><L><E><V><L><K><I><H><V><L><E><D><M><N><E><F><T><V><H><I><L><E><T><V><N><A><H><M><M><L><D><K><A><R><R><D><T><T><V><E><S><V><P><V><S><P><S><E><V><N><D><A><G><D><N><D><E><S><H><R><N><F><I><Q><D><E><V><L><R><L><I><H><E><C><P><H><Q><E><G><K><S><I><H><E><L><R><A><Q><L><C><D><L><S><V><K><A><I><K><E><A><I><D><Y><L><T><V><E><G><H><I><Y><P><T><V><D><R><E><H><F><K><S><A><D>
As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<BOP>
Q13156
Q9NZK5
ADA2_HUMAN
Cat eye syndrome critical region protein 1
Homo
<M><L><V><D><G><P><S><E><R><P><A><L><C><F><L><L><L><A><V><A><M><S><F><F><G><S><A><L><S><I><D><E><T><R><A><H><L><L><L><K><E><K><M><M><R><L><G><G><R><L><V><L><N><T><K><E><E><L><A><N><E><R><L><M><T><L><K><I><A><E><M><K><E><A><M><R><T><L><I><F><P><P><S><M><H><F><F><Q><A><K><H><L><I><E><R><S><Q><V><F><N><I><L><R><M><M><P><K><G><A><A><L><H><L><H><D><I><G><I><V><T><M><D><W><L><V><R><N><V><T><Y><R><P><H><C><H><I><C><F><T><P><R><G><I><M><Q><F><R><F><A><H><P><T><P><R><P><S><E><K><C><S><K><W><I><L><L><E><D><Y><R><K><R><V><Q><N><V><T><E><F><D><D><S><L><L><R><N><F><T><L><V><T><Q><H><P><E><V><I><Y><T><N><Q><N><V><V><W><S><K><F><E><T><I><F><F><T><I><S><G><L><I><H><Y><A><P><V><F><R><D><Y><V><F><R><S><M><Q><E><F><Y><E><D><N><V><L><Y><M><E><I><R><A><R><L><L><P><V><Y><E><L><S><G><E><H><H><D><E><E><W><S><V><K><T><Y><Q><E><V><A><Q><K><F><V><E><T><H><P><E><F><I><G><I><K><I><I><Y><S><D><H><R><S><K><D><V><A><V><I><A><E><S><I><R><M><A><M><G><L><R><I><K><F><P><T><V><V><A><G><F><D><L><V><G><H><E><D><T><G><H><S><L><H><D><Y><K><E><A><L><M><I><P><A><K><D><G><V><K><L><P><Y><F><F><H><A><G><E><T><D><W><Q><G><T><S><I><D><R><N><I><L><D><A><L><M><L><N><T><T><R><I><G><H><G><F><A><L><S><K><H><P><A><V><R><T><Y><S><W><K><K><D><I><P><I><E><V><C><P><I><S><N><Q><V><L><K><L><V><S><D><L><R><N><H><P><V><A><T><L><M><A><T><G><H><P><M><V><I><S><S><D><D><P><A><M><F><G><A><K><G><L><S><Y><D><F><Y><E><V><F><M><G><I><G><G><M><K><A><D><L><R><T><L><K><Q><L><A><M><N><S><I><K><Y><S><T><L><L><E><S><E><K><N><T><F><M><E><I><W><K><K><R><W><D><K><F><I><A><D><V><A><T><K>
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.<BOP>
Q9NZK5
Q13772
NCOA4_HUMAN
Ret-activating protein ELE1
Homo
<M><N><T><F><Q><D><Q><S><G><S><S><S><N><R><E><P><L><L><R><C><S><D><A><R><R><D><L><E><L><A><I><G><G><V><L><R><A><E><Q><Q><I><K><D><N><L><R><E><V><K><A><Q><I><H><S><C><I><S><R><H><L><E><C><L><R><S><R><E><V><W><L><Y><E><Q><V><D><L><I><Y><Q><L><K><E><E><T><L><Q><Q><Q><A><Q><Q><L><Y><S><L><L><G><Q><F><N><C><L><T><H><Q><L><E><C><T><Q><N><K><D><L><A><N><Q><V><S><V><C><L><E><R><L><G><S><L><T><L><K><P><E><D><S><T><V><L><L><F><E><A><D><T><I><T><L><R><Q><T><I><T><T><F><G><S><L><K><T><I><Q><I><P><E><H><L><M><A><H><A><S><S><A><N><I><G><P><F><L><E><K><R><G><C><I><S><M><P><E><Q><K><S><A><S><G><I><V><A><V><P><F><S><E><W><L><L><G><S><K><P><A><S><G><Y><Q><A><P><Y><I><P><S><T><D><P><Q><D><W><L><T><Q><K><Q><T><L><E><N><S><Q><T><S><S><R><A><C><N><F><F><N><N><V><G><G><N><L><K><G><L><E><N><W><L><L><K><S><E><K><S><S><Y><Q><K><C><N><S><H><S><T><T><S><S><F><S><I><E><M><E><K><V><G><D><Q><E><L><P><D><Q><D><E><M><D><L><S><D><W><L><V><T><P><Q><E><S><H><K><L><R><K><P><E><N><G><S><R><E><T><S><E><K><F><K><L><L><F><Q><S><Y><N><V><N><D><W><L><V><K><T><D><S><C><T><N><C><Q><G><N><Q><P><K><G><V><E><I><E><N><L><G><N><L><K><C><L><N><D><H><L><E><A><K><K><P><L><S><T><P><S><M><V><T><E><D><W><L><V><Q><N><H><Q><D><P><C><K><V><E><E><V><C><R><A><N><E><P><C><T><S><F><A><E><C><V><C><D><E><N><C><E><K><E><A><L><Y><K><W><L><L><K><K><E><G><K><D><K><N><G><M><P><V><E><P><K><P><E><P><E><K><H><K><D><S><L><N><M><W><L><C><P><R><K><E><V><I><E><Q><T><K><A><P><K><A><M><T><P><S><R><I><A><D><S><F><Q><V><I><K><N><S><P><L><S><E><W><L><I><R><P><P><Y><K><E><G><S><P><K><E><V><P><G><T><E><D><R><A><G><K><Q><K><F><K><S><P><M><N><T><S><W><C><S><F><N><T><A><D><W><V><L><P><G><K><K><M><G><N><L><S><Q><L><S><S><G><E><D><K><W><L><L><R><K><K><A><Q><E><V><L><L><N><S><P><L><Q><E><E><H><N><F><P><P><D><H><Y><G><L><P><A><V><C><D><L><F><A><C><M><Q><L><K><V><D><K><E><K><W><L><Y><R><T><P><L><Q><M>
Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.<BOP>
Q13772
O75380
NDUS6_HUMAN
NADH-ubiquinone oxidoreductase 13 kDa-A subunit
Homo
<M><A><A><A><M><T><F><C><R><L><L><N><R><C><G><E><A><A><R><S><L><P><L><G><A><R><C><F><G><V><R><V><S><P><T><G><E><K><V><T><H><T><G><Q><V><Y><D><D><K><D><Y><R><R><I><R><F><V><G><R><Q><K><E><V><N><E><N><F><A><I><D><L><I><A><E><Q><P><V><S><E><V><E><T><R><V><I><A><C><D><G><G><G><G><A><L><G><H><P><K><V><Y><I><N><L><D><K><E><T><K><T><G><T><C><G><Y><C><G><L><Q><F><R><Q><H><H><H>
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP>
O75380
P22303
ACES_HUMAN
Acetylcholinesterase
Homo
<M><R><P><P><Q><C><L><L><H><T><P><S><L><A><S><P><L><L><L><L><L><L><W><L><L><G><G><G><V><G><A><E><G><R><E><D><A><E><L><L><V><T><V><R><G><G><R><L><R><G><I><R><L><K><T><P><G><G><P><V><S><A><F><L><G><I><P><F><A><E><P><P><M><G><P><R><R><F><L><P><P><E><P><K><Q><P><W><S><G><V><V><D><A><T><T><F><Q><S><V><C><Y><Q><Y><V><D><T><L><Y><P><G><F><E><G><T><E><M><W><N><P><N><R><E><L><S><E><D><C><L><Y><L><N><V><W><T><P><Y><P><R><P><T><S><P><T><P><V><L><V><W><I><Y><G><G><G><F><Y><S><G><A><S><S><L><D><V><Y><D><G><R><F><L><V><Q><A><E><R><T><V><L><V><S><M><N><Y><R><V><G><A><F><G><F><L><A><L><P><G><S><R><E><A><P><G><N><V><G><L><L><D><Q><R><L><A><L><Q><W><V><Q><E><N><V><A><A><F><G><G><D><P><T><S><V><T><L><F><G><E><S><A><G><A><A><S><V><G><M><H><L><L><S><P><P><S><R><G><L><F><H><R><A><V><L><Q><S><G><A><P><N><G><P><W><A><T><V><G><M><G><E><A><R><R><R><A><T><Q><L><A><H><L><V><G><C><P><P><G><G><T><G><G><N><D><T><E><L><V><A><C><L><R><T><R><P><A><Q><V><L><V><N><H><E><W><H><V><L><P><Q><E><S><V><F><R><F><S><F><V><P><V><V><D><G><D><F><L><S><D><T><P><E><A><L><I><N><A><G><D><F><H><G><L><Q><V><L><V><G><V><V><K><D><E><G><S><Y><F><L><V><Y><G><A><P><G><F><S><K><D><N><E><S><L><I><S><R><A><E><F><L><A><G><V><R><V><G><V><P><Q><V><S><D><L><A><A><E><A><V><V><L><H><Y><T><D><W><L><H><P><E><D><P><A><R><L><R><E><A><L><S><D><V><V><G><D><H><N><V><V><C><P><V><A><Q><L><A><G><R><L><A><A><Q><G><A><R><V><Y><A><Y><V><F><E><H><R><A><S><T><L><S><W><P><L><W><M><G><V><P><H><G><Y><E><I><E><F><I><F><G><I><P><L><D><P><S><R><N><Y><T><A><E><E><K><I><F><A><Q><R><L><M><R><Y><W><A><N><F><A><R><T><G><D><P><N><E><P><R><D><P><K><A><P><Q><W><P><P><Y><T><A><G><A><Q><Q><Y><V><S><L><D><L><R><P><L><E><V><R><R><G><L><R><A><Q><A><C><A><F><W><N><R><F><L><P><K><L><L><S><A><T><D><T><L><D><E><A><E><R><Q><W><K><A><E><F><H><R><W><S><S><Y><M><V><H><W><K><N><Q><F><D><H><Y><S><K><Q><D><R><C><S><D><L>
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.<BOP>
P22303
Q13596
SNX1_HUMAN
Sorting nexin-1
Homo
<M><A><S><G><G><G><G><C><S><A><S><E><R><L><P><P><P><F><P><G><L><E><P><E><S><E><G><A><A><G><G><S><E><P><E><A><G><D><S><D><T><E><G><E><D><I><F><T><G><A><A><V><V><S><K><H><Q><S><P><K><I><T><T><S><L><L><P><I><N><N><G><S><K><E><N><G><I><H><E><E><Q><D><Q><E><P><Q><D><L><F><A><D><A><T><V><E><L><S><L><D><S><T><Q><N><N><Q><K><K><V><L><A><K><T><L><I><S><L><P><P><Q><E><A><T><N><S><S><K><P><Q><P><T><Y><E><E><L><E><E><E><E><Q><E><D><Q><F><D><L><T><V><G><I><T><D><P><E><K><I><G><D><G><M><N><A><Y><V><A><Y><K><V><T><T><Q><T><S><L><P><L><F><R><S><K><Q><F><A><V><K><R><R><F><S><D><F><L><G><L><Y><E><K><L><S><E><K><H><S><Q><N><G><F><I><V><P><P><P><P><E><K><S><L><I><G><M><T><K><V><K><V><G><K><E><D><S><S><S><A><E><F><L><E><K><R><R><A><A><L><E><R><Y><L><Q><R><I><V><N><H><P><T><M><L><Q><D><P><D><V><R><E><F><L><E><K><E><E><L><P><R><A><V><G><T><Q><T><L><S><G><A><G><L><L><K><M><F><N><K><A><T><D><A><V><S><K><M><T><I><K><M><N><E><S><D><I><W><F><E><E><K><L><Q><E><V><E><C><E><E><Q><R><L><R><K><L><H><A><V><V><E><T><L><V><N><H><R><K><E><L><A><L><N><T><A><Q><F><A><K><S><L><A><M><L><G><S><S><E><D><N><T><A><L><S><R><A><L><S><Q><L><A><E><V><E><E><K><I><E><Q><L><H><Q><E><Q><A><N><N><D><F><F><L><L><A><E><L><L><S><D><Y><I><R><L><L><A><I><V><R><A><A><F><D><Q><R><M><K><T><W><Q><R><W><Q><D><A><Q><A><T><L><Q><K><K><R><E><A><E><A><R><L><L><W><A><N><K><P><D><K><L><Q><Q><A><K><D><E><I><L><E><W><E><S><R><V><T><Q><Y><E><R><D><F><E><R><I><S><T><V><V><R><K><E><V><I><R><F><E><K><E><K><S><K><D><F><K><N><H><V><I><K><Y><L><E><T><L><L><Y><S><Q><Q><Q><L><A><K><Y><W><E><A><F><L><P><E><A><K><A><I><S>
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity . Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi . Involvement in ret
Q13596
P13765
DOB_HUMAN
MHC class II antigen DOB
Homo
<M><G><S><G><W><V><P><W><V><V><A><L><L><V><N><L><T><R><L><D><S><S><M><T><Q><G><T><D><S><P><E><D><F><V><I><Q><A><K><A><D><C><Y><F><T><N><G><T><E><K><V><Q><F><V><V><R><F><I><F><N><L><E><E><Y><V><R><F><D><S><D><V><G><M><F><V><A><L><T><K><L><G><Q><P><D><A><E><Q><W><N><S><R><L><D><L><L><E><R><S><R><Q><A><V><D><G><V><C><R><H><N><Y><R><L><G><A><P><F><T><V><G><R><K><V><Q><P><E><V><T><V><Y><P><E><R><T><P><L><L><H><Q><H><N><L><L><H><C><S><V><T><G><F><Y><P><G><D><I><K><I><K><W><F><L><N><G><Q><E><E><R><A><G><V><M><S><T><G><P><I><R><N><G><D><W><T><F><Q><T><V><V><M><L><E><M><T><P><E><L><G><H><V><Y><T><C><L><V><D><H><S><S><L><L><S><P><V><S><V><E><W><R><A><Q><S><E><Y><S><W><R><K><M><L><S><G><I><A><A><F><L><L><G><L><I><F><L><L><V><G><I><V><I><Q><L><R><A><Q><K><G><Y><V><R><T><Q><M><S><G><N><E><V><S><R><A><V><L><L><P><Q><S><C>
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.<BOP>
P13765
Q3LI72
KR195_HUMAN
Keratin-associated protein 19-5
Homo
<M><N><Y><Y><G><N><Y><Y><G><G><L><G><Y><G><Y><G><G><F><D><D><L><G><Y><G><Y><G><C><G><C><G><S><F><R><R><L><G><Y><G><G><G><Y><G><G><Y><G><Y><G><S><G><F><G><G><Y><G><Y><R><S><C><R><P><S><C><Y><G><G><Y><G><F><S><G><F><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI72
Q6PHR2
ULK3_HUMAN
Unc-51-like kinase 3
Homo
<M><A><G><P><G><W><G><P><P><R><L><D><G><F><I><L><T><E><R><L><G><S><G><T><Y><A><T><V><Y><K><A><Y><A><K><K><D><T><R><E><V><V><A><I><K><C><V><A><K><K><S><L><N><K><A><S><V><E><N><L><L><T><E><I><E><I><L><K><G><I><R><H><P><H><I><V><Q><L><K><D><F><Q><W><D><S><D><N><I><Y><L><I><M><E><F><C><A><G><G><D><L><S><R><F><I><H><T><R><R><I><L><P><E><K><V><A><R><V><F><M><Q><Q><L><A><S><A><L><Q><F><L><H><E><R><N><I><S><H><L><D><L><K><P><Q><N><I><L><L><S><S><L><E><K><P><H><L><K><L><A><D><F><G><F><A><Q><H><M><S><P><W><D><E><K><H><V><L><R><G><S><P><L><Y><M><A><P><E><M><V><C><Q><R><Q><Y><D><A><R><V><D><L><W><S><M><G><V><I><L><Y><E><A><L><F><G><Q><P><P><F><A><S><R><S><F><S><E><L><E><E><K><I><R><S><N><R><V><I><E><L><P><L><R><P><L><L><S><R><D><C><R><D><L><L><Q><R><L><L><E><R><D><P><S><R><R><I><S><F><Q><D><F><F><A><H><P><W><V><D><L><E><H><M><P><S><G><E><S><L><G><R><A><T><A><L><V><V><Q><A><V><K><K><D><Q><E><G><D><S><A><A><A><L><S><L><Y><C><K><A><L><D><F><F><V><P><A><L><H><Y><E><V><D><A><Q><R><K><E><A><I><K><A><K><V><G><Q><Y><V><S><R><A><E><E><L><K><A><I><V><S><S><S><N><Q><A><L><L><R><Q><G><T><S><A><R><D><L><L><R><E><M><A><R><D><K><P><R><L><L><A><A><L><E><V><A><S><A><A><M><A><K><E><E><A><A><G><G><E><Q><D><A><L><D><L><Y><Q><H><S><L><G><E><L><L><L><L><L><A><A><E><P><P><G><R><R><R><E><L><L><H><T><E><V><Q><N><L><M><A><R><A><E><Y><L><K><E><Q><V><K><M><R><E><S><R><W><E><A><D><T><L><D><K><E><G><L><S><E><S><V><R><S><S><C><T><L><Q>
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.<BOP>
Q6PHR2
Q6UXZ0
TMIG1_HUMAN
null
Homo
<M><A><W><K><S><S><V><I><M><Q><M><G><R><F><L><L><L><V><I><L><F><L><P><R><E><M><T><S><S><V><L><T><V><N><G><K><T><E><N><Y><I><L><D><T><T><P><G><S><Q><A><S><L><I><C><A><V><Q><N><H><T><R><E><E><E><L><L><W><Y><R><E><E><G><R><V><D><L><K><S><G><N><K><I><N><S><S><S><V><C><V><S><S><I><S><E><N><D><N><G><I><S><F><T><C><R><L><G><R><D><Q><S><V><S><V><S><V><V><L><N><V><T><F><P><P><L><L><S><G><N><D><F><Q><T><V><E><E><G><S><N><V><K><L><V><C><N><V><K><A><N><P><Q><A><Q><M><M><W><Y><K><N><S><S><L><L><D><L><E><K><S><R><H><Q><I><Q><Q><T><S><E><S><F><Q><L><S><I><T><K><V><E><K><P><D><N><G><T><Y><S><C><I><A><K><S><S><L><K><T><E><S><L><D><F><H><L><I><V><K><D><K><T><V><G><V><P><I><E><P><I><I><A><A><C><V><V><I><F><L><T><L><C><F><G><L><I><A><R><R><K><K><I><M><K><L><C><M><K><D><K><D><P><H><S><E><T><A><L>
May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival.<BOP>
Q6UXZ0
P78371
TCPB_HUMAN
CCT-beta
Homo
<M><A><S><L><S><L><A><P><V><N><I><F><K><A><G><A><D><E><E><R><A><E><T><A><R><L><T><S><F><I><G><A><I><A><I><G><D><L><V><K><S><T><L><G><P><K><G><M><D><K><I><L><L><S><S><G><R><D><A><S><L><M><V><T><N><D><G><A><T><I><L><K><N><I><G><V><D><N><P><A><A><K><V><L><V><D><M><S><R><V><Q><D><D><E><V><G><D><G><T><T><S><V><T><V><L><A><A><E><L><L><R><E><A><E><S><L><I><A><K><K><I><H><P><Q><T><I><I><A><G><W><R><E><A><T><K><A><A><R><E><A><L><L><S><S><A><V><D><H><G><S><D><E><V><K><F><R><Q><D><L><M><N><I><A><G><T><T><L><S><S><K><L><L><T><H><H><K><D><H><F><T><K><L><A><V><E><A><V><L><R><L><K><G><S><G><N><L><E><A><I><H><I><I><K><K><L><G><G><S><L><A><D><S><Y><L><D><E><G><F><L><L><D><K><K><I><G><V><N><Q><P><K><R><I><E><N><A><K><I><L><I><A><N><T><G><M><D><T><D><K><I><K><I><F><G><S><R><V><R><V><D><S><T><A><K><V><A><E><I><E><H><A><E><K><E><K><M><K><E><K><V><E><R><I><L><K><H><G><I><N><C><F><I><N><R><Q><L><I><Y><N><Y><P><E><Q><L><F><G><A><A><G><V><M><A><I><E><H><A><D><F><A><G><V><E><R><L><A><L><V><T><G><G><E><I><A><S><T><F><D><H><P><E><L><V><K><L><G><S><C><K><L><I><E><E><V><M><I><G><E><D><K><L><I><H><F><S><G><V><A><L><G><E><A><C><T><I><V><L><R><G><A><T><Q><Q><I><L><D><E><A><E><R><S><L><H><D><A><L><C><V><L><A><Q><T><V><K><D><S><R><T><V><Y><G><G><G><C><S><E><M><L><M><A><H><A><V><T><Q><L><A><N><R><T><P><G><K><E><A><V><A><M><E><S><Y><A><K><A><L><R><M><L><P><T><I><I><A><D><N><A><G><Y><D><S><A><D><L><V><A><Q><L><R><A><A><H><S><E><G><N><T><T><A><G><L><D><M><R><E><G><T><I><G><D><M><A><I><L><G><I><T><E><S><F><Q><V><K><R><Q><V><L><L><S><A><A><E><A><A><E><V><I><L><R><V><D><N><I><I><K><A><A><P><R><K><R><V><P><D><H><H><P><C>
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable).<BOP>
P78371
P52799
EFNB2_HUMAN
HTK ligand
Homo
<M><A><V><R><R><D><S><V><W><K><Y><C><W><G><V><L><M><V><L><C><R><T><A><I><S><K><S><I><V><L><E><P><I><Y><W><N><S><S><N><S><K><F><L><P><G><Q><G><L><V><L><Y><P><Q><I><G><D><K><L><D><I><I><C><P><K><V><D><S><K><T><V><G><Q><Y><E><Y><Y><K><V><Y><M><V><D><K><D><Q><A><D><R><C><T><I><K><K><E><N><T><P><L><L><N><C><A><K><P><D><Q><D><I><K><F><T><I><K><F><Q><E><F><S><P><N><L><W><G><L><E><F><Q><K><N><K><D><Y><Y><I><I><S><T><S><N><G><S><L><E><G><L><D><N><Q><E><G><G><V><C><Q><T><R><A><M><K><I><L><M><K><V><G><Q><D><A><S><S><A><G><S><T><R><N><K><D><P><T><R><R><P><E><L><E><A><G><T><N><G><R><S><S><T><T><S><P><F><V><K><P><N><P><G><S><S><T><D><G><N><S><A><G><H><S><G><N><N><I><L><G><S><E><V><A><L><F><A><G><I><A><S><G><C><I><I><F><I><V><I><I><I><T><L><V><V><L><L><L><K><Y><R><R><R><H><R><K><H><S><P><Q><H><T><T><T><L><S><L><S><T><L><A><T><P><K><R><S><G><N><N><N><G><S><E><P><S><D><I><I><I><P><L><R><T><A><D><S><V><F><C><P><H><Y><E><K><V><S><G><D><Y><G><H><P><V><Y><I><V><Q><E><M><P><P><Q><S><P><A><N><I><Y><Y><K><V>
(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.<BOP>
P52799
Q92947
GCDH_HUMAN
Glutaryl-CoA dehydrogenase, mitochondrial
Homo
<M><A><L><R><G><V><S><V><R><L><L><S><R><G><P><G><L><H><V><L><R><T><W><V><S><S><A><A><Q><T><E><K><G><G><R><T><Q><S><Q><L><A><K><S><S><R><P><E><F><D><W><Q><D><P><L><V><L><E><E><Q><L><T><T><D><E><I><L><I><R><D><T><F><R><T><Y><C><Q><E><R><L><M><P><R><I><L><L><A><N><R><N><E><V><F><H><R><E><I><I><S><E><M><G><E><L><G><V><L><G><P><T><I><K><G><Y><G><C><A><G><V><S><S><V><A><Y><G><L><L><A><R><E><L><E><R><V><D><S><G><Y><R><S><A><M><S><V><Q><S><S><L><V><M><H><P><I><Y><A><Y><G><S><E><E><Q><R><Q><K><Y><L><P><Q><L><A><K><G><E><L><L><G><C><F><G><L><T><E><P><N><S><G><S><D><P><S><S><M><E><T><R><A><H><Y><N><S><S><N><K><S><Y><T><L><N><G><T><K><T><W><I><T><N><S><P><M><A><D><L><F><V><V><W><A><R><C><E><D><G><C><I><R><G><F><L><L><E><K><G><M><R><G><L><S><A><P><R><I><Q><G><K><F><S><L><R><A><S><A><T><G><M><I><I><M><D><G><V><E><V><P><E><E><N><V><L><P><G><A><S><S><L><G><G><P><F><G><C><L><N><N><A><R><Y><G><I><A><W><G><V><L><G><A><S><E><F><C><L><H><T><A><R><Q><Y><A><L><D><R><M><Q><F><G><V><P><L><A><R><N><Q><L><I><Q><K><K><L><A><D><M><L><T><E><I><T><L><G><L><H><A><C><L><Q><L><G><R><L><K><D><Q><D><K><A><A><P><E><M><V><S><L><L><K><R><N><N><C><G><K><A><L><D><I><A><R><Q><A><R><D><M><L><G><G><N><G><I><S><D><E><Y><H><V><I><R><H><A><M><N><L><E><A><V><N><T><Y><E><G><T><H><D><I><H><A><L><I><L><G><R><A><I><T><G><I><Q><A><F><T><A><S><K>
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.<BOP>
Q92947
Q7Z5L7
PODN_HUMAN
Podocan
Homo
<M><A><Q><S><R><V><L><L><L><L><L><L><L><P><P><Q><L><H><L><G><P><V><L><A><V><R><A><P><G><F><G><R><S><G><G><H><S><L><S><P><E><E><N><E><F><A><E><E><E><P><V><L><V><L><S><P><E><E><P><G><P><G><P><A><A><V><S><C><P><R><D><C><A><C><S><Q><E><G><V><V><D><C><G><G><I><D><L><R><E><F><P><G><D><L><P><E><H><T><N><H><L><S><L><Q><N><N><Q><L><E><K><I><Y><P><E><E><L><S><R><L><H><R><L><E><T><L><N><L><Q><N><N><R><L><T><S><R><G><L><P><E><K><A><F><E><H><L><T><N><L><N><Y><L><Y><L><A><N><N><K><L><T><L><A><P><R><F><L><P><N><A><L><I><S><V><D><F><A><A><N><Y><L><T><K><I><Y><G><L><T><F><G><Q><K><P><N><L><R><S><V><Y><L><H><N><N><K><L><A><D><A><G><L><P><D><N><M><F><N><G><S><S><N><V><E><V><L><I><L><S><S><N><F><L><R><H><V><P><K><H><L><P><P><A><L><Y><K><L><H><L><K><N><N><K><L><E><K><I><P><P><G><A><F><S><E><L><S><S><L><R><E><L><Y><L><Q><N><N><Y><L><T><D><E><G><L><D><N><E><T><F><W><K><L><S><S><L><E><Y><L><D><L><S><S><N><N><L><S><R><V><P><A><G><L><P><R><S><L><V><L><L><H><L><E><K><N><A><I><R><S><V><D><A><N><V><L><T><P><I><R><S><L><E><Y><L><L><L><H><S><N><Q><L><R><E><Q><G><I><H><P><L><A><F><Q><G><L><K><R><L><H><T><V><H><L><Y><N><N><A><L><E><R><V><P><S><G><L><P><R><R><V><R><T><L><M><I><L><H><N><Q><I><T><G><I><G><R><E><D><F><A><T><T><Y><F><L><E><E><L><N><L><S><Y><N><R><I><T><S><P><Q><V><H><R><D><A><F><R><K><L><R><L><L><R><S><L><D><L><S><G><N><R><L><H><T><L><P><P><G><L><P><R><N><V><H><V><L><K><V><K><R><N><E><L><A><A><L><A><R><G><A><L><V><G><M><A><Q><L><R><E><L><Y><L><T><S><N><R><L><R><S><R><A><L><G><P><R><A><W><V><D><L><A><H><L><Q><L><L><D><I><A><G><N><Q><L><T><E><I><P><E><G><L><P><E><S><L><E><Y><L><Y><L><Q><N><N><K><I><S><A><V><P><A><N><A><F><D><S><T><P><N><L><K><G><I><F><L><R><F><N><K><L><A><V><G><S><V><V><D><S><A><F><R><R><L><K><H><L><Q><V><L><D><I><E><G><N><L><E><F><G><D><I><S><K><D><R><G><R><L><G><K><E><K><E><E><E><E><E><E><E><E><E><E><E><E><T><R>
Negatively regulates cell proliferation and cell migration.<BOP>
Q7Z5L7
P00439
PH4H_HUMAN
Phe-4-monooxygenase
Homo
<M><S><T><A><V><L><E><N><P><G><L><G><R><K><L><S><D><F><G><Q><E><T><S><Y><I><E><D><N><C><N><Q><N><G><A><I><S><L><I><F><S><L><K><E><E><V><G><A><L><A><K><V><L><R><L><F><E><E><N><D><V><N><L><T><H><I><E><S><R><P><S><R><L><K><K><D><E><Y><E><F><F><T><H><L><D><K><R><S><L><P><A><L><T><N><I><I><K><I><L><R><H><D><I><G><A><T><V><H><E><L><S><R><D><K><K><K><D><T><V><P><W><F><P><R><T><I><Q><E><L><D><R><F><A><N><Q><I><L><S><Y><G><A><E><L><D><A><D><H><P><G><F><K><D><P><V><Y><R><A><R><R><K><Q><F><A><D><I><A><Y><N><Y><R><H><G><Q><P><I><P><R><V><E><Y><M><E><E><E><K><K><T><W><G><T><V><F><K><T><L><K><S><L><Y><K><T><H><A><C><Y><E><Y><N><H><I><F><P><L><L><E><K><Y><C><G><F><H><E><D><N><I><P><Q><L><E><D><V><S><Q><F><L><Q><T><C><T><G><F><R><L><R><P><V><A><G><L><L><S><S><R><D><F><L><G><G><L><A><F><R><V><F><H><C><T><Q><Y><I><R><H><G><S><K><P><M><Y><T><P><E><P><D><I><C><H><E><L><L><G><H><V><P><L><F><S><D><R><S><F><A><Q><F><S><Q><E><I><G><L><A><S><L><G><A><P><D><E><Y><I><E><K><L><A><T><I><Y><W><F><T><V><E><F><G><L><C><K><Q><G><D><S><I><K><A><Y><G><A><G><L><L><S><S><F><G><E><L><Q><Y><C><L><S><E><K><P><K><L><L><P><L><E><L><E><K><T><A><I><Q><N><Y><T><V><T><E><F><Q><P><L><Y><Y><V><A><E><S><F><N><D><A><K><E><K><V><R><N><F><A><A><T><I><P><R><P><F><S><V><R><Y><D><P><Y><T><Q><R><I><E><V><L><D><N><T><Q><Q><L><K><I><L><A><D><S><I><N><S><E><I><G><I><L><C><S><A><L><Q><K><I><K>
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine.<BOP>
P00439
Q6DKI7
PVRIG_HUMAN
Poliovirus receptor-related immunoglobulin domain-containing protein
Homo
<M><R><T><E><A><Q><V><P><A><L><Q><P><P><E><P><G><L><E><G><A><M><G><H><R><T><L><V><L><P><W><V><L><L><T><L><C><V><T><A><G><T><P><E><V><W><V><Q><V><R><M><E><A><T><E><L><S><S><F><T><I><R><C><G><F><L><G><S><G><S><I><S><L><V><T><V><S><W><G><G><P><N><G><A><G><G><T><T><L><A><V><L><H><P><E><R><G><I><R><Q><W><A><P><A><R><Q><A><R><W><E><T><Q><S><S><I><S><L><I><L><E><G><S><G><A><S><S><P><C><A><N><T><T><F><C><C><K><F><A><S><F><P><E><G><S><W><E><A><C><G><S><L><P><P><S><S><D><P><G><L><S><A><P><P><T><P><A><P><I><L><R><A><D><L><A><G><I><L><G><V><S><G><V><L><L><F><G><C><V><Y><L><L><H><L><L><R><R><H><K><H><R><P><A><P><R><L><Q><P><S><R><T><S><P><Q><A><P><R><A><R><A><W><A><P><S><Q><A><S><Q><A><A><L><H><V><P><Y><A><T><I><N><T><S><C><R><P><A><T><L><D><T><A><H><P><H><G><G><P><S><W><W><A><S><L><P><T><H><A><A><H><R><P><Q><G><P><A><A><W><A><S><T><P><I><P><A><R><G><S><F><V><S><V><E><N><G><L><Y><A><Q><A><G><E><R><P><P><H><T><G><P><G><L><T><L><F><P><D><P><R><G><P><R><A><M><E><G><P><L><G><V><R>
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.<BOP>
Q6DKI7
Q96FZ7
CHMP6_HUMAN
Vacuolar protein sorting-associated protein 20
Homo
<M><G><N><L><F><G><R><K><K><Q><S><R><V><T><E><Q><D><K><A><I><L><Q><L><K><Q><Q><R><D><K><L><R><Q><Y><Q><K><R><I><A><Q><Q><L><E><R><E><R><A><L><A><R><Q><L><L><R><D><G><R><K><E><R><A><K><L><L><L><K><K><K><R><Y><Q><E><Q><L><L><D><R><T><E><N><Q><I><S><S><L><E><A><M><V><Q><S><I><E><F><T><Q><I><E><M><K><V><M><E><G><L><Q><F><G><N><E><C><L><N><K><M><H><Q><V><M><S><I><E><E><V><E><R><I><L><D><E><T><Q><E><A><V><E><Y><Q><R><Q><I><D><E><L><L><A><G><S><F><T><Q><E><D><E><D><A><I><L><E><E><L><S><A><I><T><Q><E><Q><I><E><L><P><E><V><P><S><E><P><L><P><E><K><I><P><E><N><V><P><V><K><A><R><P><R><Q><A><E><L><V><A><A><S>
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.<BOP>
Q96FZ7
Q8NGJ3
O52E1_HUMAN
Olfactory receptor 52E1
Homo
<M><N><T><T><L><F><H><P><Y><S><F><L><L><L><G><I><P><G><L><E><S><M><H><L><W><V><G><F><P><F><F><A><V><F><L><T><A><V><L><G><N><I><T><I><L><F><V><I><Q><T><D><S><S><L><H><H><P><M><F><Y><F><L><A><I><L><S><S><I><D><P><G><L><S><T><S><T><I><P><K><M><L><G><T><F><W><F><T><L><R><E><I><S><F><E><G><C><L><T><Q><M><F><F><I><H><L><C><T><G><M><E><S><A><V><L><V><A><M><A><Y><D><C><Y><V><A><I><C><D><P><L><C><Y><T><L><V><L><T><N><K><V><V><S><V><M><A><L><A><I><F><L><R><P><L><V><F><V><I><P><F><V><L><F><I><L><R><L><P><F><C><G><H><Q><I><I><P><H><T><Y><G><E><H><M><G><I><A><R><L><S><C><A><S><I><R><V><N><I><I><Y><G><L><C><A><I><S><I><L><V><F><D><I><I><A><I><V><I><S><Y><V><Q><I><L><C><A><V><F><L><L><S><S><H><D><A><R><L><K><A><F><S><T><C><G><S><H><V><C><V><M><L><T><F><Y><M><P><A><F><F><S><F><M><T><H><R><F><G><R><N><I><P><H><F><I><H><I><L><L><A><N><F><Y><V><V><I><P><P><A><L><N><S><V><I><Y><G><V><R><T><K><Q><I><R><A><Q><V><L><K><M><F><F><N><K>
Odorant receptor.<BOP>
Q8NGJ3
Q8TDV2
GP148_HUMAN
G-protein coupled receptor PGR6
Homo
<M><G><D><E><L><A><P><C><P><V><G><T><T><A><W><P><A><L><I><Q><L><I><S><K><T><P><C><M><P><Q><A><A><S><N><T><S><L><G><L><G><D><L><R><V><P><S><S><M><L><Y><W><L><F><L><P><S><S><L><L><A><A><A><T><L><A><V><S><P><L><L><L><V><T><I><L><R><N><Q><R><L><R><Q><E><P><H><Y><L><L><P><A><N><I><L><L><S><D><L><A><Y><I><L><L><H><M><L><I><S><S><S><S><L><G><G><W><E><L><G><R><M><A><C><G><I><L><T><D><A><V><F><A><A><C><T><S><T><I><L><S><F><T><A><I><V><L><H><T><Y><L><A><V><I><H><P><L><R><Y><L><S><F><M><S><H><G><A><A><W><K><A><V><A><L><I><W><L><V><A><C><C><F><P><T><F><L><I><W><L><S><K><W><Q><D><A><Q><L><E><E><Q><G><A><S><Y><I><L><P><P><S><M><G><T><Q><P><G><C><G><L><L><V><I><V><T><Y><T><S><I><L><C><V><L><F><L><C><T><A><L><I><A><N><C><F><W><R><I><Y><A><E><A><K><T><S><G><I><W><G><Q><G><Y><S><R><A><R><G><T><L><L><I><H><S><V><L><I><T><L><Y><V><S><T><G><V><V><F><S><L><D><M><V><L><T><R><Y><H><H><I><D><S><G><T><H><T><W><L><L><A><A><N><S><E><V><L><M><M><L><P><R><A><M><L><T><Y><L><Y><L><L><R><Y><R><Q><L><L><G><M><V><R><G><H><L><P><S><R><R><H><Q><A><I><F><T><I><S>
Orphan receptor.<BOP>
Q8TDV2
Q6PEY0
CXB7_HUMAN
Connexin-25
Homo
<M><S><W><M><F><L><R><D><L><L><S><G><V><N><K><Y><S><T><G><T><G><W><I><W><L><A><V><V><F><V><F><R><L><L><V><Y><M><V><A><A><E><H><V><W><K><D><E><Q><K><E><F><E><C><N><S><R><Q><P><G><C><K><N><V><C><F><D><D><F><F><P><I><S><Q><V><R><L><W><A><L><Q><L><I><M><V><S><T><P><S><L><L><V><V><L><H><V><A><Y><H><E><G><R><E><K><R><H><R><K><K><L><Y><V><S><P><G><T><M><D><G><G><L><W><Y><A><Y><L><I><S><L><I><V><K><T><G><F><E><I><G><F><L><V><L><F><Y><K><L><Y><D><G><F><S><V><P><Y><L><I><K><C><D><L><K><P><C><P><N><T><V><D><C><F><I><S><K><P><T><E><K><T><I><F><I><L><F><L><V><I><T><S><C><L><C><I><V><L><N><F><I><E><L><S><F><L><V><L><K><C><F><I><K><C><C><L><Q><K><Y><L><K><K><P><Q><V><L><S><V>
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP>
Q6PEY0
Q9P0K8
FOXJ2_HUMAN
Fork head homologous X
Homo
<M><A><S><D><L><E><S><S><L><T><S><I><D><W><L><P><Q><L><T><L><R><A><T><I><E><K><L><G><S><A><S><Q><A><G><P><P><G><S><S><R><K><C><S><P><G><S><P><T><D><P><N><A><T><L><S><K><D><E><A><A><V><H><Q><D><G><K><P><R><Y><S><Y><A><T><L><I><T><Y><A><I><N><S><S><P><A><K><K><M><T><L><S><E><I><Y><R><W><I><C><D><N><F><P><Y><Y><K><N><A><G><I><G><W><K><N><S><I><R><H><N><L><S><L><N><K><C><F><R><K><V><P><R><P><R><D><D><P><G><K><G><S><Y><W><T><I><D><T><C><P><D><I><S><R><K><R><R><H><P><P><D><D><D><L><S><Q><D><S><P><E><Q><E><A><S><K><S><P><R><G><G><V><A><G><S><G><E><A><S><L><P><P><E><G><N><P><Q><M><S><L><Q><S><P><T><S><I><A><S><Y><S><Q><G><T><G><S><V><D><G><G><A><V><A><A><G><A><S><G><R><E><S><A><E><G><P><P><P><L><Y><N><T><N><H><D><F><K><F><S><Y><S><E><I><N><F><Q><D><L><S><W><S><F><R><N><L><Y><K><S><M><L><E><K><S><S><S><S><S><Q><H><G><F><S><S><L><L><G><D><I><P><P><S><N><N><Y><Y><M><Y><Q><Q><Q><Q><P><P><P><P><Q><Q><Q><Q><Q><Q><Q><Q><P><P><Q><P><P><P><Q><Q><S><Q><P><Q><Q><Q><Q><A><P><A><Q><G><P><S><A><V><G><G><A><P><P><L><H><T><P><S><T><D><G><C><T><P><P><G><G><K><Q><A><G><A><E><G><Y><G><P><P><P><V><M><A><M><H><P><P><P><L><Q><H><G><G><Y><H><P><H><Q><H><H><P><H><S><H><P><A><Q><Q><P><P><P><P><Q><P><Q><A><Q><G><Q><A><P><I><N><N><T><G><F><A><F><P><S><D><W><C><S><N><I><D><S><L><K><E><S><F><K><M><V><N><R><L><N><W><S><S><I><E><Q><S><Q><F><S><E><L><M><E><S><L><R><Q><A><E><Q><K><N><W><T><L><D><Q><H><H><I><A><N><L><C><D><S><L><N><H><F><L><T><Q><T><G><H><V><P><P><Q><G><G><T><H><R><P><P><A><P><A><R><I><A><D><S><C><A><L><T><S><G><K><Q><E><S><A><M><S><Q><V><N><S><Y><G><H><P><Q><A><P><H><L><Y><P><G><P><S><P><M><Y><P><I><P><T><Q><D><S><A><G><Y><N><R><P><A><H><H><M><V><P><R><P><S><V><P><P><P><G><A><N><E><E><I><P><D><D><F><D><W><D><L><I><T>
Transcriptional activator.<BOP>
Q9P0K8
Q9Y258
CCL26_HUMAN
Thymic stroma chemokine-1
Homo
<M><M><G><L><S><L><A><S><A><V><L><L><A><S><L><L><S><L><H><L><G><T><A><T><R><G><S><D><I><S><K><T><C><C><F><Q><Y><S><H><K><P><L><P><W><T><W><V><R><S><Y><E><F><T><S><N><S><C><S><Q><R><A><V><I><F><T><T><K><R><G><K><K><V><C><T><H><P><R><K><K><W><V><Q><K><Y><I><S><L><L><K><T><P><K><Q><L>
Chemoattractant for eosinophils and basophils . Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils . Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis .<BOP>
Q9Y258
Q969Q1
TRI63_HUMAN
Tripartite motif-containing protein 63
Homo
<M><D><Y><K><S><S><L><I><Q><D><G><N><P><M><E><N><L><E><K><Q><L><I><C><P><I><C><L><E><M><F><T><K><P><V><V><I><L><P><C><Q><H><N><L><C><R><K><C><A><N><D><I><F><Q><A><A><N><P><Y><W><T><S><R><G><S><S><V><S><M><S><G><G><R><F><R><C><P><T><C><R><H><E><V><I><M><D><R><H><G><V><Y><G><L><Q><R><N><L><L><V><E><N><I><I><D><I><Y><K><Q><E><C><S><S><R><P><L><Q><K><G><S><H><P><M><C><K><E><H><E><D><E><K><I><N><I><Y><C><L><T><C><E><V><P><T><C><S><M><C><K><V><F><G><I><H><K><A><C><E><V><A><P><L><Q><S><V><F><Q><G><Q><K><T><E><L><N><N><C><I><S><M><L><V><A><G><N><D><R><V><Q><T><I><I><T><Q><L><E><D><S><R><R><V><T><K><E><N><S><H><Q><V><K><E><E><L><S><Q><K><F><D><T><L><Y><A><I><L><D><E><K><K><S><E><L><L><Q><R><I><T><Q><E><Q><E><K><K><L><S><F><I><E><A><L><I><Q><Q><Y><Q><E><Q><L><D><K><S><T><K><L><V><E><T><A><I><Q><S><L><D><E><P><G><G><A><T><F><L><L><T><A><K><Q><L><I><K><S><I><V><E><A><S><K><G><C><Q><L><G><K><T><E><Q><G><F><E><N><M><D><F><F><T><L><D><L><E><H><I><A><D><A><L><R><A><I><D><F><G><T><D><E><E><E><E><E><F><I><E><E><E><D><Q><E><E><E><E><S><T><E><G><K><E><E><G><H><Q>
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<BOP>
Q969Q1
Q9NXH9
TRM1_HUMAN
tRNA(m(2,2)G26)dimethyltransferase
Homo
<M><Q><G><S><S><L><W><L><S><L><T><F><R><S><A><R><V><L><S><R><A><R><F><F><E><W><Q><S><P><G><L><P><N><T><A><A><M><E><N><G><T><G><P><Y><G><E><E><R><P><R><E><V><Q><E><T><T><V><T><E><G><A><A><K><I><A><F><P><S><A><N><E><V><F><Y><N><P><V><Q><E><F><N><R><D><L><T><C><A><V><I><T><E><F><A><R><I><Q><L><G><A><K><G><I><Q><I><K><V><P><G><E><K><D><T><Q><K><V><V><V><D><L><S><E><Q><E><E><E><K><V><E><L><K><E><S><E><N><L><A><S><G><D><Q><P><R><T><A><A><V><G><E><I><C><E><E><G><L><H><V><L><E><G><L><A><A><S><G><L><R><S><I><R><F><A><L><E><V><P><G><L><R><S><V><V><A><N><D><A><S><T><R><A><V><D><L><I><R><R><N><V><Q><L><N><D><V><A><H><L><V><Q><P><S><Q><A><D><A><R><M><L><M><Y><Q><H><Q><R><V><S><E><R><F><D><V><I><D><L><D><P><Y><G><S><P><A><T><F><L><D><A><A><V><Q><A><V><S><E><G><G><L><L><C><V><T><C><T><D><M><A><V><L><A><G><N><S><G><E><T><C><Y><S><K><Y><G><A><M><A><L><K><S><R><A><C><H><E><M><A><L><R><I><V><L><H><S><L><D><L><R><A><N><C><Y><Q><R><F><V><V><P><L><L><S><I><S><A><D><F><Y><V><R><V><F><V><R><V><F><T><G><Q><A><K><V><K><A><S><A><S><K><Q><A><L><V><F><Q><C><V><G><C><G><A><F><H><L><Q><R><L><G><K><A><S><G><V><P><S><G><R><A><K><F><S><A><A><C><G><P><P><V><T><P><E><C><E><H><C><G><Q><R><H><Q><L><G><G><P><M><W><A><E><P><I><H><D><L><D><F><V><G><R><V><L><E><A><V><S><A><N><P><G><R><F><H><T><S><E><R><I><R><G><V><L><S><V><I><T><E><E><L><P><D><V><P><L><Y><Y><T><L><D><Q><L><S><S><T><I><H><C><N><T><P><S><L><L><Q><L><R><S><A><L><L><H><A><D><F><R><V><S><L><S><H><A><C><K><N><A><V><K><T><D><A><P><A><S><A><L><W><D><I><M><R><C><W><E><K><E><C><P><V><K><R><E><R><L><S><E><T><S><P><A><F><R><I><L><S><V><E><P><R><L><Q><A><N><F><T><I><R><E><D><A><N><P><S><S><R><Q><R><G><L><K><R><F><Q><A><N><P><E><A><N><W><G><P><R><P><R><A><R><P><G><G><K><A><A><D><E><A><M><E><E><R><R><R><L><L><Q><N><K><R><K><E><P><P><E><D><V><A><Q><R><A><A><R><L><K><T><F><P><C><K><R><F><K><E><G><T><C><Q><R><G><D><Q><C><C><Y><S><H><S><P><P><T><P><R><V><S><A><D><A><A><P><D><C><P><E><T><S><N><Q><T><P><P><G><P><G><A><A><A><G><P><G><I><D>
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.<BOP>
Q9NXH9
Q99879
H2B1M_HUMAN
Histone H2B.e
Homo
<M><P><E><P><V><K><S><A><P><V><P><K><K><G><S><K><K><A><I><N><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
Q99879
P10072
ZN875_HUMAN
Protein HKR1
Homo
<M><R><V><N><H><T><V><S><T><M><L><P><T><C><M><V><H><R><Q><T><M><S><C><S><G><A><G><G><I><T><A><F><V><A><F><R><D><V><A><V><Y><F><T><Q><E><E><W><R><L><L><S><P><A><Q><R><T><L><H><R><E><V><M><L><E><T><Y><N><H><L><V><S><L><E><I><P><S><S><K><P><K><L><I><A><Q><L><E><R><G><E><A><P><W><R><E><E><R><K><C><P><L><D><L><C><P><E><S><K><P><E><I><Q><L><S><P><S><C><P><L><I><F><S><S><Q><Q><A><L><S><Q><H><V><W><L><S><H><L><S><Q><L><F><S><S><L><W><A><G><N><P><L><H><L><G><K><H><Y><P><E><D><Q><K><Q><Q><Q><D><P><F><C><F><S><G><K><A><E><W><I><Q><E><G><E><D><S><R><L><L><F><G><R><V><S><K><N><G><T><S><K><A><L><S><S><P><P><E><E><Q><Q><P><A><Q><S><K><E><D><N><T><V><V><D><I><G><S><S><P><E><R><R><A><D><L><E><E><T><D><K><V><L><H><G><L><E><V><S><G><F><G><E><I><K><Y><E><E><F><G><P><G><F><I><K><E><S><N><L><L><S><L><Q><K><T><Q><T><G><E><T><P><Y><M><Y><T><E><W><G><D><S><F><G><S><M><S><V><L><I><K><N><P><R><T><H><S><G><G><K><P><Y><V><C><R><E><C><G><R><G><F><T><W><K><S><N><L><I><T><H><Q><R><T><H><S><G><E><K><P><Y><V><C><K><D><C><G><R><G><F><T><W><K><S><N><L><F><T><H><Q><R><T><H><S><G><L><K><P><Y><V><C><K><E><C><G><Q><S><F><S><L><K><S><N><L><I><T><H><Q><R><A><H><T><G><E><K><P><Y><V><C><R><E><C><G><R><G><F><R><Q><H><S><H><L><V><R><H><K><R><T><H><S><G><E><K><P><Y><I><C><R><E><C><E><Q><G><F><S><Q><K><S><H><L><I><R><H><L><R><T><H><T><G><E><K><P><Y><V><C><T><E><C><G><R><H><F><S><W><K><S><N><L><K><T><H><Q><R><T><H><S><G><V><K><P><Y><V><C><L><E><C><G><Q><C><F><S><L><K><S><N><L><N><K><H><Q><R><S><H><T><G><E><K><P><F><V><C><T><E><C><G><R><G><F><T><R><K><S><T><L><S><T><H><Q><R><T><H><S><G><E><K><P><F><V><C><A><E><C><G><R><G><F><N><D><K><S><T><L><I><S><H><Q><R><T><H><S><G><E><K><P><F><M><C><R><E><C><G><R><R><F><R><Q><K><P><N><L><F><R><H><K><R><A><H><S><G><A><F><V><C><R><E><C><G><Q><G><F><C><A><K><L><T><L><I><K><H><Q><R><A><H><A><G><G><K><P><H><V><C><R><E><C><G><Q><G><F><S><R><Q><S><H><L><I><R><H><Q><R><T><H><S><G><E><K><P><Y><I><C><R><K><C><G><R><G><F><S><R><K><S><N><L><I><R><H><Q><R><T><H><S><G>
May be involved in transcriptional regulation.<BOP>
P10072
Q8N370
LAT4_HUMAN
Solute carrier family 43 member 2
Homo
<M><A><P><T><L><A><T><A><H><R><R><R><W><W><M><A><C><T><A><V><L><E><N><L><L><F><S><A><V><L><L><G><W><G><S><L><L><I><M><L><K><S><E><G><F><Y><S><Y><L><C><T><E><P><E><N><V><T><N><G><T><V><G><G><T><A><E><P><G><H><E><E><V><S><W><M><N><G><W><L><S><C><Q><A><Q><D><E><M><L><N><L><A><F><T><V><G><S><F><L><L><S><A><I><T><L><P><L><G><I><V><M><D><K><Y><G><P><R><K><L><R><L><L><G><S><A><C><F><A><V><S><C><L><L><I><A><Y><G><A><S><K><P><N><A><L><S><V><L><I><F><I><A><L><A><L><N><G><F><G><G><M><C><M><T><F><T><S><L><T><L><P><N><M><F><G><D><L><R><S><T><F><I><A><L><M><I><G><S><Y><A><S><S><A><V><T><F><P><G><I><K><L><I><Y><D><A><G><V><S><F><I><V><V><L><V><V><W><A><G><C><S><G><L><V><F><L><N><C><F><F><N><W><P><L><E><P><F><P><G><P><E><D><M><D><Y><S><V><K><I><K><F><S><W><L><G><F><D><H><K><I><T><G><K><Q><F><Y><K><Q><V><T><T><V><G><R><R><L><S><V><G><S><S><M><R><S><A><K><E><Q><V><A><L><Q><E><G><H><K><L><C><L><S><T><V><D><L><E><V><K><C><Q><P><D><A><A><V><A><P><S><F><M><H><S><V><F><S><P><I><L><L><L><S><L><V><T><M><C><V><T><Q><L><R><L><I><F><Y><M><G><A><M><N><N><I><L><K><F><L><V><S><G><D><Q><K><T><V><G><L><Y><T><S><I><F><G><V><L><Q><L><L><C><L><L><T><A><P><V><I><G><Y><I><M><D><W><R><L><K><E><C><E><D><A><S><E><E><P><E><E><K><D><A><N><Q><G><E><K><K><K><K><K><R><D><R><Q><I><Q><K><I><T><N><A><M><R><A><F><A><F><T><N><L><L><L><V><G><F><G><V><T><C><L><I><P><N><L><P><L><Q><I><L><S><F><I><L><H><T><I><V><R><G><F><I><H><S><A><V><G><G><L><Y><A><A><V><Y><P><S><T><Q><F><G><S><L><T><G><L><Q><S><L><I><S><A><L><F><A><L><L><Q><Q><P><L><F><L><A><M><M><G><P><L><Q><G><D><P><L><W><V><N><V><G><L><L><L><L><S><L><L><G><F><C><L><P><L><Y><L><I><C><Y><R><R><Q><L><E><R><Q><L><Q><Q><R><Q><E><D><D><K><L><F><L><K><I><N><G><S><S><N><Q><E><A><F><V>
Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.<BOP>
Q8N370
P62633
CNBP_HUMAN
Zinc finger protein 9
Homo
<M><S><S><N><E><C><F><K><C><G><R><S><G><H><W><A><R><E><C><P><T><G><G><G><R><G><R><G><M><R><S><R><G><R><G><G><F><T><S><D><R><G><F><Q><F><V><S><S><S><L><P><D><I><C><Y><R><C><G><E><S><G><H><L><A><K><D><C><D><L><Q><E><D><A><C><Y><N><C><G><R><G><G><H><I><A><K><D><C><K><E><P><K><R><E><R><E><Q><C><C><Y><N><C><G><K><P><G><H><L><A><R><D><C><D><H><A><D><E><Q><K><C><Y><S><C><G><E><F><G><H><I><Q><K><D><C><T><K><V><K><C><Y><R><C><G><E><T><G><H><V><A><I><N><C><S><K><T><S><E><V><N><C><Y><R><C><G><E><S><G><H><L><A><R><E><C><T><I><E><A><T><A>
Binds to RNA.<BOP>
P62633
Q96MU8
KREM1_HUMAN
Kringle-containing protein marking the eye and the nose
Homo
<M><A><P><P><A><A><R><L><A><L><L><S><A><A><A><L><T><L><A><A><R><P><A><P><S><P><G><L><G><P><E><C><F><T><A><N><G><A><D><Y><R><G><T><Q><N><W><T><A><L><Q><G><G><K><P><C><L><F><W><N><E><T><F><Q><H><P><Y><N><T><L><K><Y><P><N><G><E><G><G><L><G><E><H><N><Y><C><R><N><P><D><G><D><V><S><P><W><C><Y><V><A><E><H><E><D><G><V><Y><W><K><Y><C><E><I><P><A><C><Q><M><P><G><N><L><G><C><Y><K><D><H><G><N><P><P><P><L><T><G><T><S><K><T><S><N><K><L><T><I><Q><T><C><I><S><F><C><R><S><Q><R><F><K><F><A><G><M><E><S><G><Y><A><C><F><C><G><N><N><P><D><Y><W><K><Y><G><E><A><A><S><T><E><C><N><S><V><C><F><G><D><H><T><Q><P><C><G><G><D><G><R><I><I><L><F><D><T><L><V><G><A><C><G><G><N><Y><S><A><M><S><S><V><V><Y><S><P><D><F><P><D><T><Y><A><T><G><R><V><C><Y><W><T><I><R><V><P><G><A><S><H><I><H><F><S><F><P><L><F><D><I><R><D><S><A><D><M><V><E><L><L><D><G><Y><T><H><R><V><L><A><R><F><H><G><R><S><R><P><P><L><S><F><N><V><S><L><D><F><V><I><L><Y><F><F><S><D><R><I><N><Q><A><Q><G><F><A><V><L><Y><Q><A><V><K><E><E><L><P><Q><E><R><P><A><V><N><Q><T><V><A><E><V><I><T><E><Q><A><N><L><S><V><S><A><A><R><S><S><K><V><L><Y><V><I><T><T><S><P><S><H><P><P><Q><T><V><P><G><S><N><S><W><A><P><P><M><G><A><G><S><H><R><V><E><G><W><T><V><Y><G><L><A><T><L><L><I><L><T><V><T><A><I><V><A><K><I><L><L><H><V><T><F><K><S><H><R><V><P><A><S><G><D><L><R><D><C><H><Q><P><G><T><S><G><E><I><W><S><I><F><Y><K><P><S><T><S><I><S><I><F><K><K><K><L><K><G><Q><S><Q><Q><D><D><R><N><P><L><V><S><D>
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.<BOP>
Q96MU8
C9JE40
PATL2_HUMAN
Protein PAT1 homolog a
Homo
<M><N><C><L><E><G><P><G><K><T><C><G><P><L><A><S><E><E><E><L><V><S><A><C><Q><L><E><K><E><E><E><N><E><G><E><E><E><E><E><E><E><D><E><E><D><L><D><P><D><L><D><P><D><L><E><E><E><E><N><D><L><G><D><P><A><V><L><G><A><V><H><N><T><Q><R><A><L><L><S><S><P><G><V><K><A><P><G><M><L><G><M><S><L><A><S><L><H><F><L><W><Q><T><L><D><Y><L><S><P><I><P><F><W><P><T><F><P><S><T><S><S><P><A><Q><H><F><G><P><R><L><P><S><P><D><P><T><L><F><C><S><L><L><T><S><W><P><P><R><F><S><H><L><T><Q><L><H><P><R><H><Q><R><I><L><Q><Q><Q><Q><H><S><Q><T><P><S><P><P><A><K><K><P><W><S><Q><Q><P><D><P><Y><A><N><L><M><T><R><K><E><K><D><W><V><I><K><V><Q><M><V><Q><L><Q><S><A><K><P><R><L><D><D><Y><Y><Y><Q><E><Y><Y><Q><K><L><E><K><K><Q><A><D><E><E><L><L><G><R><R><N><R><V><E><S><L><K><L><V><T><P><Y><I><P><K><A><E><A><Y><E><S><V><V><R><I><E><G><S><L><G><Q><V><A><V><S><T><C><F><S><P><R><R><A><I><D><A><V><P><H><G><T><Q><E><Q><D><I><E><A><A><S><S><Q><R><L><R><V><L><Y><R><I><E><K><M><F><L><Q><L><L><E><I><E><E><G><W><K><Y><R><P><P><P><P><C><F><S><E><Q><Q><S><N><Q><V><E><K><L><F><Q><T><L><K><T><Q><E><Q><N><N><L><E><E><A><A><D><G><F><L><Q><V><L><S><V><R><K><G><K><A><L><V><A><R><L><L><P><F><L><P><Q><D><Q><A><V><T><I><L><L><A><I><T><H><H><L><P><L><L><V><R><R><D><V><A><D><Q><A><L><Q><M><L><F><K><P><L><G><K><C><I><S><H><L><T><L><H><E><L><L><Q><G><L><Q><G><L><T><L><L><P><P><G><S><S><E><R><P><V><T><V><V><L><Q><N><Q><F><G><I><S><L><L><Y><A><L><L><S><H><G><E><Q><L><V><S><L><H><S><S><L><E><E><P><N><S><D><H><T><A><W><T><D><M><V><V><L><I><A><W><E><I><A><Q><M><P><T><A><S><L><A><E><P><L><A><F><P><S><N><L><L><P><L><F><C><H><H><V><D><K><Q><L><V><Q><Q><L><E><A><R><M><E><F><A><W><I><Y>
RNA-binding protein that acts as a translational repressor.<BOP>
C9JE40
Q08629
TICN1_HUMAN
Protein SPOCK
Homo
<M><P><A><I><A><V><L><A><A><A><A><A><A><W><C><F><L><Q><V><E><S><R><H><L><D><A><L><A><G><G><A><G><P><N><H><G><N><F><L><D><N><D><Q><W><L><S><T><V><S><Q><Y><D><R><D><K><Y><W><N><R><F><R><D><D><D><Y><F><R><N><W><N><P><N><K><P><F><D><Q><A><L><D><P><S><K><D><P><C><L><K><V><K><C><S><P><H><K><V><C><V><T><Q><D><Y><Q><T><A><L><C><V><S><R><K><H><L><L><P><R><Q><K><K><G><N><V><A><Q><K><H><W><V><G><P><S><N><L><V><K><C><K><P><C><P><V><A><Q><S><A><M><V><C><G><S><D><G><H><S><Y><T><S><K><C><K><L><E><F><H><A><C><S><T><G><K><S><L><A><T><L><C><D><G><P><C><P><C><L><P><E><P><E><P><P><K><H><K><A><E><R><S><A><C><T><D><K><E><L><R><N><L><A><S><R><L><K><D><W><F><G><A><L><H><E><D><A><N><R><V><I><K><P><T><S><S><N><T><A><Q><G><R><F><D><T><S><I><L><P><I><C><K><D><S><L><G><W><M><F><N><K><L><D><M><N><Y><D><L><L><L><D><P><S><E><I><N><A><I><Y><L><D><K><Y><E><P><C><I><K><P><L><F><N><S><C><D><S><F><K><D><G><K><L><S><N><N><E><W><C><Y><C><F><Q><K><P><G><G><L><P><C><Q><N><E><M><N><R><I><Q><K><L><S><K><G><K><S><L><L><G><A><F><I><P><R><C><N><E><E><G><Y><Y><K><A><T><Q><C><H><G><S><T><G><Q><C><W><C><V><D><K><Y><G><N><E><L><A><G><S><R><K><Q><G><A><V><S><C><E><E><E><Q><E><T><S><G><D><F><G><S><G><G><S><V><V><L><L><D><D><L><E><Y><E><R><E><L><G><P><K><D><K><E><G><K><L><R><V><H><T><R><A><V><T><E><D><D><E><D><E><D><D><D><K><E><D><E><V><G><Y><I><W>
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.<BOP>
Q08629
P16118
F261_HUMAN
Fructose-2,6-bisphosphatase
Homo
<M><S><P><E><M><G><E><L><T><Q><T><R><L><Q><K><I><W><I><P><H><S><S><G><S><S><R><L><Q><R><R><R><G><S><S><I><P><Q><F><T><N><S><P><T><M><V><I><M><V><G><L><P><A><R><G><K><T><Y><I><S><T><K><L><T><R><Y><L><N><W><I><G><T><P><T><K><V><F><N><L><G><Q><Y><R><R><E><A><V><S><Y><K><N><Y><E><F><F><L><P><D><N><M><E><A><L><Q><I><R><K><Q><C><A><L><A><A><L><K><D><V><H><N><Y><L><S><H><E><E><G><H><V><A><V><F><D><A><T><N><T><T><R><E><R><R><S><L><I><L><Q><F><A><K><E><H><G><Y><K><V><F><F><I><E><S><I><C><N><D><P><G><I><I><A><E><N><I><R><Q><V><K><L><G><S><P><D><Y><I><D><C><D><R><E><K><V><L><E><D><F><L><K><R><I><E><C><Y><E><V><N><Y><Q><P><L><D><E><E><L><D><S><H><L><S><Y><I><K><I><F><D><V><G><T><R><Y><M><V><N><R><V><Q><D><H><I><Q><S><R><T><V><Y><Y><L><M><N><I><H><V><T><P><R><S><I><Y><L><C><R><H><G><E><S><E><L><N><I><R><G><R><I><G><G><D><S><G><L><S><V><R><G><K><Q><Y><A><Y><A><L><A><N><F><I><Q><S><Q><G><I><S><S><L><K><V><W><T><S><H><M><K><R><T><I><Q><T><A><E><A><L><G><V><P><Y><E><Q><W><K><A><L><N><E><I><D><A><G><V><C><E><E><M><T><Y><E><E><I><Q><E><H><Y><P><E><E><F><A><L><R><D><Q><D><K><Y><R><Y><R><Y><P><K><G><E><S><Y><E><D><L><V><Q><R><L><E><P><V><I><M><E><L><E><R><Q><E><N><V><L><V><I><C><H><Q><A><V><M><R><C><L><L><A><Y><F><L><D><K><S><S><D><E><L><P><Y><L><K><C><P><L><H><T><V><L><K><L><T><P><V><A><Y><G><C><K><V><E><S><I><Y><L><N><V><E><A><V><N><T><H><R><E><K><P><E><N><V><D><I><T><R><E><P><E><E><A><L><D><T><V><P><A><H><Y>
Synthesis and degradation of fructose 2,6-bisphosphate.<BOP>
P16118
Q9UHY8
FEZ2_HUMAN
Zygin-2
Homo
<M><A><A><D><G><D><W><Q><D><F><Y><E><F><Q><E><P><A><R><S><L><L><D><Q><E><N><C><N><A><S><P><E><P><G><A><E><A><G><A><E><A><G><G><G><A><D><G><F><P><A><P><A><C><S><L><E><E><K><L><S><L><C><F><R><P><S><D><P><G><A><E><P><P><R><T><A><V><R><P><I><T><E><R><S><L><L><Q><G><D><E><I><W><N><A><L><T><D><N><Y><G><N><V><M><P><V><D><W><K><S><S><H><T><R><T><L><H><L><L><T><L><N><L><S><E><K><G><V><S><D><S><L><L><F><D><T><S><D><D><E><E><L><R><E><Q><L><D><M><H><S><I><I><V><S><C><V><N><D><E><P><L><F><T><A><D><Q><V><I><E><E><I><E><E><M><M><Q><E><S><P><D><P><E><D><D><E><T><P><T><Q><S><D><R><L><S><M><L><S><Q><E><I><Q><T><L><K><R><S><S><T><G><S><Y><E><E><R><V><K><R><L><S><V><S><E><L><N><E><I><L><E><E><I><E><T><A><I><K><E><Y><S><E><E><L><V><Q><Q><L><A><L><R><D><E><L><E><F><E><K><E><V><K><N><S><F><I><S><V><L><I><E><V><Q><N><K><Q><K><E><H><K><E><T><A><K><K><K><K><K><L><K><N><G><S><S><Q><N><G><K><N><E><R><S><H><M><P><G><T><Y><L><T><T><V><I><P><Y><E><K><K><N><G><P><P><S><V><E><D><L><Q><I><L><T><K><I><L><R><A><M><K><E><D><S><E><K><V><P><S><L><L><T><D><Y><I><L><K><V><L><C><P><T>
Involved in axonal outgrowth and fasciculation.<BOP>
Q9UHY8
P17787
ACHB2_HUMAN
Neuronal acetylcholine receptor subunit beta-2
Homo
<M><A><R><R><C><G><P><V><A><L><L><L><G><F><G><L><L><R><L><C><S><G><V><W><G><T><D><T><E><E><R><L><V><E><H><L><L><D><P><S><R><Y><N><K><L><I><R><P><A><T><N><G><S><E><L><V><T><V><Q><L><M><V><S><L><A><Q><L><I><S><V><H><E><R><E><Q><I><M><T><T><N><V><W><L><T><Q><E><W><E><D><Y><R><L><T><W><K><P><E><E><F><D><N><M><K><K><V><R><L><P><S><K><H><I><W><L><P><D><V><V><L><Y><N><N><A><D><G><M><Y><E><V><S><F><Y><S><N><A><V><V><S><Y><D><G><S><I><F><W><L><P><P><A><I><Y><K><S><A><C><K><I><E><V><K><H><F><P><F><D><Q><Q><N><C><T><M><K><F><R><S><W><T><Y><D><R><T><E><I><D><L><V><L><K><S><E><V><A><S><L><D><D><F><T><P><S><G><E><W><D><I><V><A><L><P><G><R><R><N><E><N><P><D><D><S><T><Y><V><D><I><T><Y><D><F><I><I><R><R><K><P><L><F><Y><T><I><N><L><I><I><P><C><V><L><I><T><S><L><A><I><L><V><F><Y><L><P><S><D><C><G><E><K><M><T><L><C><I><S><V><L><L><A><L><T><V><F><L><L><L><I><S><K><I><V><P><P><T><S><L><D><V><P><L><V><G><K><Y><L><M><F><T><M><V><L><V><T><F><S><I><V><T><S><V><C><V><L><N><V><H><H><R><S><P><T><T><H><T><M><A><P><W><V><K><V><V><F><L><E><K><L><P><A><L><L><F><M><Q><Q><P><R><H><H><C><A><R><Q><R><L><R><L><R><R><R><Q><R><E><R><E><G><A><G><A><L><F><F><R><E><A><P><G><A><D><S><C><T><C><F><V><N><R><A><S><V><Q><G><L><A><G><A><F><G><A><E><P><A><P><V><A><G><P><G><R><S><G><E><P><C><G><C><G><L><R><E><A><V><D><G><V><R><F><I><A><D><H><M><R><S><E><D><D><D><Q><S><V><S><E><D><W><K><Y><V><A><M><V><I><D><R><L><F><L><W><I><F><V><F><V><C><V><F><G><T><I><G><M><F><L><Q><P><L><F><Q><N><Y><T><T><T><T><F><L><H><S><D><H><S><A><P><S><S><K>
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.<BOP>
P17787
Q96EG1
ARSG_HUMAN
N-sulfoglucosamine-3-sulfatase
Homo
<M><G><W><L><F><L><K><V><L><L><A><G><V><S><F><S><G><F><L><Y><P><L><V><D><F><C><I><S><G><K><T><R><G><Q><K><P><N><F><V><I><I><L><A><D><D><M><G><W><G><D><L><G><A><N><W><A><E><T><K><D><T><A><N><L><D><K><M><A><S><E><G><M><R><F><V><D><F><H><A><A><A><S><T><C><S><P><S><R><A><S><L><L><T><G><R><L><G><L><R><N><G><V><T><R><N><F><A><V><T><S><V><G><G><L><P><L><N><E><T><T><L><A><E><V><L><Q><Q><A><G><Y><V><T><G><I><I><G><K><W><H><L><G><H><H><G><S><Y><H><P><N><F><R><G><F><D><Y><Y><F><G><I><P><Y><S><H><D><M><G><C><T><D><T><P><G><Y><N><H><P><P><C><P><A><C><P><Q><G><D><G><P><S><R><N><L><Q><R><D><C><Y><T><D><V><A><L><P><L><Y><E><N><L><N><I><V><E><Q><P><V><N><L><S><S><L><A><Q><K><Y><A><E><K><A><T><Q><F><I><Q><R><A><S><T><S><G><R><P><F><L><L><Y><V><A><L><A><H><M><H><V><P><L><P><V><T><Q><L><P><A><A><P><R><G><R><S><L><Y><G><A><G><L><W><E><M><D><S><L><V><G><Q><I><K><D><K><V><D><H><T><V><K><E><N><T><F><L><W><F><T><G><D><N><G><P><W><A><Q><K><C><E><L><A><G><S><V><G><P><F><T><G><F><W><Q><T><R><Q><G><G><S><P><A><K><Q><T><T><W><E><G><G><H><R><V><P><A><L><A><Y><W><P><G><R><V><P><V><N><V><T><S><T><A><L><L><S><V><L><D><I><F><P><T><V><V><A><L><A><Q><A><S><L><P><Q><G><R><R><F><D><G><V><D><V><S><E><V><L><F><G><R><S><Q><P><G><H><R><V><L><F><H><P><N><S><G><A><A><G><E><F><G><A><L><Q><T><V><R><L><E><R><Y><K><A><F><Y><I><T><G><G><A><R><A><C><D><G><S><T><G><P><E><L><Q><H><K><F><P><L><I><F><N><L><E><D><D><T><A><E><A><V><P><L><E><R><G><G><A><E><Y><Q><A><V><L><P><E><V><R><K><V><L><A><D><V><L><Q><D><I><A><N><D><N><I><S><S><A><D><Y><T><Q><D><P><S><V><T><P><C><C><N><P><Y><Q><I><A><C><R><C><Q><A><A>
Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate . Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin .<BOP>
Q96EG1
P31150
GDIA_HUMAN
Protein XAP-4
Homo
<M><D><E><E><Y><D><V><I><V><L><G><T><G><L><T><E><C><I><L><S><G><I><M><S><V><N><G><K><K><V><L><H><M><D><R><N><P><Y><Y><G><G><E><S><S><S><I><T><P><L><E><E><L><Y><K><R><F><Q><L><L><E><G><P><P><E><S><M><G><R><G><R><D><W><N><V><D><L><I><P><K><F><L><M><A><N><G><Q><L><V><K><M><L><L><Y><T><E><V><T><R><Y><L><D><F><K><V><V><E><G><S><F><V><Y><K><G><G><K><I><Y><K><V><P><S><T><E><T><E><A><L><A><S><N><L><M><G><M><F><E><K><R><R><F><R><K><F><L><V><F><V><A><N><F><D><E><N><D><P><K><T><F><E><G><V><D><P><Q><T><T><S><M><R><D><V><Y><R><K><F><D><L><G><Q><D><V><I><D><F><T><G><H><A><L><A><L><Y><R><T><D><D><Y><L><D><Q><P><C><L><E><T><V><N><R><I><K><L><Y><S><E><S><L><A><R><Y><G><K><S><P><Y><L><Y><P><L><Y><G><L><G><E><L><P><Q><G><F><A><R><L><S><A><I><Y><G><G><T><Y><M><L><N><K><P><V><D><D><I><I><M><E><N><G><K><V><V><G><V><K><S><E><G><E><V><A><R><C><K><Q><L><I><C><D><P><S><Y><I><P><D><R><V><R><K><A><G><Q><V><I><R><I><I><C><I><L><S><H><P><I><K><N><T><N><D><A><N><S><C><Q><I><I><I><P><Q><N><Q><V><N><R><K><S><D><I><Y><V><C><M><I><S><Y><A><H><N><V><A><A><Q><G><K><Y><I><A><I><A><S><T><T><V><E><T><T><D><P><E><K><E><V><E><P><A><L><E><L><L><E><P><I><D><Q><K><F><V><A><I><S><D><L><Y><E><P><I><D><D><G><C><E><S><Q><V><F><C><S><C><S><Y><D><A><T><T><H><F><E><T><T><C><N><D><I><K><D><I><Y><K><R><M><A><G><T><A><F><D><F><E><N><M><K><R><K><Q><N><D><V><F><G><E><A><E><Q>
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.<BOP>
P31150
A6NJL1
ZSA5B_HUMAN
Zinc finger and SCAN domain-containing protein 5B
Homo
<M><A><A><N><W><T><L><S><W><G><Q><G><G><P><C><N><S><P><G><S><D><T><P><R><S><V><A><S><P><E><T><Q><L><G><N><H><D><R><N><P><E><T><W><H><M><N><F><R><M><F><S><C><P><E><E><S><D><P><I><Q><A><L><R><K><L><T><E><L><C><H><L><W><L><R><P><D><L><H><T><K><E><Q><I><L><D><M><L><V><M><E><Q><F><M><I><S><M><P><Q><E><L><Q><V><L><V><K><V><N><G><V><Q><S><C><K><D><L><E><D><L><L><R><N><N><R><R><P><K><K><W><S><I><V><N><L><L><G><K><E><Y><L><M><L><N><S><D><V><E><M><A><E><A><P><A><S><V><R><D><D><P><R><D><V><S><S><Q><W><A><S><S><V><N><Q><M><H><P><G><T><G><Q><A><R><R><E><Q><Q><I><L><P><R><V><A><A><L><S><R><R><Q><G><E><D><F><L><L><H><K><S><I><D><V><T><G><D><P><N><S><P><R><P><K><Q><T><L><E><K><D><L><K><E><N><R><E><E><N><P><G><L><S><S><P><E><P><Q><L><P><K><S><P><N><L><V><R><A><K><E><G><K><E><P><Q><K><R><A><S><V><E><N><V><D><A><D><T><P><S><A><C><V><V><E><R><E><A><L><T><H><S><G><N><R><G><D><A><L><N><L><S><S><P><K><R><S><K><P><D><A><S><S><I><S><Q><E><E><P><Q><G><E><A><T><P><V><G><N><R><E><S><P><G><Q><A><E><I><N><P><V><H><S><P><G><P><A><G><P><V><S><H><P><D><G><Q><E><A><K><A><L><P><P><F><A><C><D><V><C><N><K><S><F><K><Y><F><S><Q><L><S><I><H><R><R><S><H><T><G><D><R><P><F><Q><C><D><L><C><R><K><R><F><L><Q><P><S><D><L><R><V><H><Q><R><V><H><T><G><E><R><P><Y><M><C><D><V><C><Q><K><R><F><A><H><E><S><T><L><Q><G><H><K><R><I><H><T><G><E><R><P><F><K><C><K><Y><C><S><K><V><F><S><H><K><G><N><L><N><V><H><Q><R><T><H><S><G><E><K><P><Y><K><C><P><T><C><Q><K><A><F><R><Q><L><G><T><F><K><R><H><L><K><T><H><R><E><T><T><S><Q>
May be involved in transcriptional regulation.<BOP>
A6NJL1
Q92521
PIGB_HUMAN
Phosphatidylinositol-glycan biosynthesis class B protein
Homo
<M><R><R><P><L><S><K><C><G><M><E><P><G><G><G><D><A><S><L><T><L><H><G><L><Q><N><R><S><H><G><K><I><K><L><R><K><R><K><S><T><L><Y><F><N><T><Q><E><K><S><A><R><R><R><G><D><L><L><G><E><N><I><Y><L><L><L><F><T><I><A><L><R><I><L><N><C><F><L><V><Q><T><S><F><V><P><D><E><Y><W><Q><S><L><E><V><S><H><H><M><V><F><N><Y><G><Y><L><T><W><E><W><T><E><R><L><R><S><Y><T><Y><P><L><I><F><A><S><I><Y><K><I><L><H><L><L><G><K><D><S><V><Q><L><L><I><W><I><P><R><L><A><Q><A><L><L><S><A><V><A><D><V><R><L><Y><S><L><M><K><Q><L><E><N><Q><E><V><A><R><W><V><F><F><C><Q><L><C><S><W><F><T><W><Y><C><C><T><R><T><L><T><N><T><M><E><T><V><L><T><I><I><A><L><F><Y><Y><P><L><E><G><S><K><S><M><N><S><V><K><Y><S><S><L><V><A><L><A><F><I><I><R><P><T><A><V><I><L><W><T><P><L><L><F><R><H><F><C><Q><E><P><R><K><L><D><L><I><L><H><H><F><L><P><V><G><F><V><T><L><S><L><S><L><M><I><D><R><I><F><F><G><Q><W><T><L><V><Q><F><N><F><L><K><F><N><V><L><Q><N><W><G><T><F><Y><G><S><H><P><W><H><W><Y><F><S><Q><G><F><P><V><I><L><G><T><H><L><P><F><F><I><H><G><C><Y><L><A><P><K><R><Y><R><I><L><L><V><T><V><L><W><T><L><L><V><Y><S><M><L><S><H><K><E><F><R><F><I><Y><P><V><L><P><F><C><M><V><F><C><G><Y><S><L><T><H><L><K><T><W><K><K><P><A><L><S><F><L><F><L><S><N><L><F><L><A><L><Y><T><G><L><V><H><Q><R><G><T><L><D><V><M><S><H><I><Q><K><V><C><Y><N><N><P><N><K><S><S><A><S><I><F><I><M><M><P><C><H><S><T><P><Y><Y><S><H><V><H><C><P><L><P><M><R><F><L><Q><C><P><P><D><L><T><G><K><S><H><Y><L><D><E><A><D><V><F><Y><L><N><P><L><N><W><L><H><R><E><F><H><D><D><A><S><L><P><T><H><L><I><T><F><S><I><L><E><E><E><I><S><A><F><L><I><S><S><N><Y><K><R><T><A><V><F><F><H><T><H><L><P><E><G><R><I><G><S><H><I><Y><V><Y><E><R><K><L><K><G><K><F><N><M><K><M><K><F>
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.<BOP>
Q92521
Q9C0H2
TTYH3_HUMAN
Protein tweety homolog 3
Homo
<M><A><G><V><S><Y><A><A><P><W><W><V><S><L><L><H><R><L><P><H><F><D><L><S><W><E><A><T><S><S><Q><F><R><P><E><D><T><D><Y><Q><Q><A><L><L><L><L><G><A><A><A><L><A><C><L><A><L><D><L><L><F><L><L><F><Y><S><F><W><L><C><C><R><R><R><K><S><E><E><H><L><D><A><D><C><C><C><T><A><W><C><V><I><I><A><T><L><V><C><S><A><G><I><A><V><G><F><Y><G><N><G><E><T><S><D><G><I><H><R><A><T><Y><S><L><R><H><A><N><R><T><V><A><G><V><Q><D><R><V><W><D><T><A><V><G><L><N><H><T><A><E><P><S><L><Q><T><L><E><R><Q><L><A><G><R><P><E><P><L><R><A><V><Q><R><L><Q><G><L><L><E><T><L><L><G><Y><T><A><A><I><P><F><W><R><N><T><A><V><S><L><E><V><L><A><E><Q><V><D><L><Y><D><W><Y><R><W><L><G><Y><L><G><L><L><L><L><D><V><I><I><C><L><L><V><L><V><G><L><I><R><S><S><K><G><I><L><V><G><V><C><L><L><G><V><L><A><L><V><I><S><W><G><A><L><G><L><E><L><A><V><S><V><G><S><S><D><F><C><V><D><P><D><A><Y><V><T><K><M><V><E><E><Y><S><V><L><S><G><D><I><L><Q><Y><Y><L><A><C><S><P><R><A><A><N><P><F><Q><Q><K><L><S><G><S><H><K><A><L><V><E><M><Q><D><V><V><A><E><L><L><R><T><V><P><W><E><Q><P><A><T><K><D><P><L><L><R><V><Q><E><V><L><N><G><T><E><V><N><L><Q><H><L><T><A><L><V><D><C><R><S><L><H><L><D><Y><V><Q><A><L><T><G><F><C><Y><D><G><V><E><G><L><I><Y><L><A><L><F><S><F><V><T><A><L><M><F><S><S><I><V><C><S><V><P><H><T><W><Q><Q><K><R><G><P><D><E><D><G><E><E><E><A><A><P><G><P><R><Q><A><H><D><S><L><Y><R><V><H><M><P><S><L><Y><S><C><G><S><S><Y><G><S><E><T><S><I><P><A><A><A><H><T><V><S><N><A><P><V><T><E><Y><M><S><Q><N><A><N><F><Q><N><P><R><C><E><N><T><P><L><I><G><R><E><S><P><P><P><S><Y><T><S><S><M><R><A><K><Y><L><A><T><S><Q><P><R><P><D><S><S><G><S><H>
Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction.<BOP>
Q9C0H2
Q8NCV1
ADAD2_HUMAN
Testis nuclear RNA-binding protein-like
Homo
<M><A><S><A><S><Q><G><A><D><D><D><G><S><R><R><K><P><R><L><A><A><S><L><Q><I><S><P><Q><P><R><P><W><R><P><L><P><A><Q><A><Q><S><A><W><G><P><A><P><A><P><A><T><Y><R><A><E><G><G><W><P><Q><V><S><V><L><R><D><S><G><P><G><A><G><A><G><V><G><E><L><G><A><A><R><A><W><E><N><L><G><E><Q><M><G><K><A><P><R><V><P><V><P><P><A><G><L><S><L><P><L><K><D><P><P><A><S><Q><A><V><S><L><L><T><E><Y><A><A><S><L><G><I><F><L><L><F><R><E><D><Q><P><P><G><P><C><F><P><F><S><V><S><A><E><L><D><G><V><V><C><P><A><G><T><A><N><S><K><T><E><A><K><Q><Q><A><A><L><S><A><L><C><Y><I><R><S><Q><L><E><N><P><E><S><P><Q><T><S><S><R><P><P><L><A><P><L><S><V><E><N><I><L><T><H><E><Q><R><C><A><A><L><V><S><A><G><F><D><L><L><L><D><E><R><S><P><Y><W><A><C><K><G><T><V><A><G><V><I><L><E><R><E><I><P><R><A><R><G><H><V><K><E><I><Y><K><L><V><A><L><G><T><G><S><S><C><C><A><G><W><L><E><F><S><G><Q><Q><L><H><D><C><H><G><L><V><I><A><R><R><A><L><L><R><F><L><F><R><Q><L><L><L><A><T><Q><G><G><P><K><G><K><E><Q><S><V><L><A><P><Q><P><G><P><G><P><P><F><T><L><K><P><R><V><F><L><H><L><Y><I><S><N><T><P><K><G><A><A><R><D><I><Y><L><P><P><T><S><E><G><G><L><P><H><S><P><P><M><R><L><Q><A><H><V><L><G><Q><L><K><P><V><C><Y><V><A><P><S><L><C><D><T><H><V><G><C><L><S><A><S><D><K><L><A><R><W><A><V><L><G><L><G><G><A><L><L><A><H><L><V><S><P><L><Y><S><T><S><L><I><L><A><D><S><C><H><D><P><P><T><L><S><R><A><I><H><T><R><P><C><L><D><S><V><L><G><P><C><L><P><P><P><Y><V><R><T><A><L><H><L><F><A><G><P><P><V><A><P><S><E><P><T><P><D><T><C><R><G><L><S><L><N><W><S><L><G><D><P><G><I><E><V><V><D><V><A><T><G><R><V><K><A><N><A><A><L><G><P><P><S><R><L><C><K><A><S><F><L><R><A><F><H><Q><A><A><R><A><V><G><K><P><Y><L><L><A><L><K><T><Y><E><A><A><K><A><G><P><Y><Q><E><A><R><R><Q><L><S><L><L><L><D><Q><Q><G><L><G><A><W><P><S><K><P><L><V><G><K><F><R><N>
Required for male fertility and normal male germ cell differentiation.<BOP>
Q8NCV1
O60412
OR7C2_HUMAN
Olfactory receptor OR19-22
Homo
<M><E><R><G><N><Q><T><E><V><G><N><F><L><L><L><G><F><A><E><D><S><D><M><Q><L><L><L><H><G><L><F><L><S><M><Y><L><V><T><I><I><G><N><L><L><I><I><L><T><I><S><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><A><D><I><C><F><T><S><T><T><V><P><K><M><L><V><N><I><Q><T><Q><S><K><M><I><T><F><A><G><C><L><T><Q><I><F><F><F><I><A><F><G><C><L><D><N><L><L><L><T><M><T><A><Y><D><R><F><V><A><I><C><Y><P><L><H><Y><T><V><I><M><N><P><R><L><C><G><L><L><V><L><G><S><W><C><I><S><V><M><G><S><L><L><E><T><L><T><I><L><R><L><S><F><C><T><N><M><E><I><P><H><F><F><C><D><P><S><E><V><L><K><L><A><C><S><D><T><F><I><N><N><I><V><M><Y><F><V><T><I><V><L><G><V><F><P><L><C><G><I><L><F><S><Y><S><Q><I><F><S><S><V><L><R><V><S><A><R><G><Q><H><K><A><F><S><T><C><G><S><H><L><S><V><V><S><L><F><Y><G><T><G><L><G><V><Y><L><S><S><A><V><T><P><P><S><R><T><S><L><A><A><S><V><M><Y><T><M><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><K><D><M><K><G><S><L><G><R><L><L><L><R><A><T><S><L><K><E><G><T><I><A><K><L><S>
Odorant receptor.<BOP>
O60412
O95208
EPN2_HUMAN
EPS-15-interacting protein 2
Homo
<M><T><T><S><S><I><R><R><Q><M><K><N><I><V><N><N><Y><S><E><A><E><I><K><V><R><E><A><T><S><N><D><P><W><G><P><S><S><S><L><M><T><E><I><A><D><L><T><Y><N><V><V><A><F><S><E><I><M><S><M><V><W><K><R><L><N><D><H><G><K><N><W><R><H><V><Y><K><A><L><T><L><L><D><Y><L><I><K><T><G><S><E><R><V><A><Q><Q><C><R><E><N><I><F><A><I><Q><T><L><K><D><F><Q><Y><I><D><R><D><G><K><D><Q><G><I><N><V><R><E><K><S><K><Q><L><V><A><L><L><K><D><E><E><R><L><K><A><E><R><A><Q><A><L><K><T><K><E><R><M><A><Q><V><A><T><G><M><G><S><N><Q><I><T><F><G><R><G><S><S><Q><P><N><L><S><T><S><H><S><E><Q><E><Y><G><K><A><G><G><S><P><A><S><Y><H><G><S><P><E><A><S><L><C><P><Q><H><R><T><G><A><P><L><G><Q><S><E><E><L><Q><P><L><S><Q><R><H><P><F><L><P><H><L><G><L><A><S><R><P><N><G><D><W><S><Q><P><C><L><T><C><D><R><A><A><R><A><T><S><P><R><V><S><S><E><L><E><Q><A><R><P><Q><T><S><G><E><E><E><L><Q><L><Q><L><A><L><A><M><S><R><E><V><A><E><Q><E><E><R><L><R><R><G><D><D><L><R><L><Q><M><A><L><E><E><S><R><R><D><T><V><K><I><P><K><K><K><E><H><G><S><L><P><Q><Q><T><T><L><L><D><L><M><D><A><L><P><S><S><G><P><A><A><Q><K><A><E><P><W><G><P><S><A><S><T><N><Q><T><N><P><W><G><G><P><A><A><P><A><S><T><S><D><P><W><P><S><F><G><T><K><P><A><A><S><I><D><P><W><G><V><P><T><G><A><T><V><Q><S><V><P><K><N><S><D><P><W><A><A><S><Q><Q><P><A><S><S><A><G><K><R><A><S><D><A><W><G><A><V><S><T><T><K><P><V><S><V><S><G><S><F><E><L><F><S><N><L><N><G><T><I><K><D><D><F><S><E><F><D><N><L><R><T><S><K><K><T><A><E><S><V><T><S><L><P><S><Q><N><N><G><T><T><S><P><D><P><F><E><S><Q><P><L><T><V><A><S><S><K><P><S><S><A><R><K><T><P><E><S><F><L><G><P><N><A><A><L><V><N><L><D><S><L><V><T><R><P><A><P><P><A><Q><S><L><N><P><F><L><A><P><G><A><P><A><T><S><A><P><V><N><P><F><Q><V><N><Q><P><Q><P><L><T><L><N><Q><L><R><G><S><P><V><L><G><T><S><T><S><F><G><P><G><P><G><V><E><S><M><A><V><A><S><M><T><S><A><A><P><Q><P><A><L><G><A><T><G><S><S><L><T><P><L><G><P><A><M><M><N><M><V><G><S><V><G><I><P><P><S><A><A><Q><A><T><G><T><T><N><P><F><L><L>
Plays a role in the formation of clathrin-coated invaginations and endocytosis.<BOP>
O95208
P47890
OR1G1_HUMAN
Olfactory receptor OR17-8
Homo
<M><E><G><K><N><L><T><S><I><S><E><C><F><L><L><G><F><S><E><Q><L><E><E><Q><K><P><L><F><G><S><F><L><F><M><Y><L><V><T><V><A><G><N><L><L><I><I><L><V><I><I><T><D><T><Q><L><H><T><P><M><Y><F><F><L><A><N><L><S><L><A><D><A><C><F><V><S><T><T><V><P><K><M><L><A><N><I><Q><I><Q><S><Q><A><I><S><Y><S><G><C><L><L><Q><L><Y><F><F><M><L><F><V><M><L><E><A><F><L><L><A><V><M><A><Y><D><C><Y><V><A><I><C><H><P><L><H><Y><I><L><I><M><S><P><G><L><C><I><F><L><V><S><A><S><W><I><M><N><A><L><H><S><L><L><H><T><L><L><M><N><S><L><S><F><C><A><N><H><E><I><P><H><F><F><C><D><I><N><P><L><L><S><L><S><C><T><D><P><F><T><N><E><L><V><I><F><I><T><G><G><L><T><G><L><I><C><V><L><C><L><I><I><S><Y><T><N><V><F><S><T><I><L><K><I><P><S><A><Q><G><K><R><K><A><F><S><T><C><S><S><H><L><S><V><V><S><L><F><F><G><T><S><F><C><V><D><F><S><S><P><S><T><H><S><A><Q><K><D><T><V><A><S><V><M><Y><T><V><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><Q><E><I><K><S><S><L><R><K><L><I><W><V><R><K><I><H><S><P>
Odorant receptor.<BOP>
P47890
Q96C74
ROP1L_HUMAN
AKAP-associated sperm protein
Homo
<M><P><L><P><D><T><M><F><C><A><Q><Q><I><H><I><P><P><E><L><P><D><I><L><K><Q><F><T><K><A><A><I><R><T><Q><P><A><D><V><L><R><W><S><A><G><Y><F><S><A><L><S><R><G><D><P><L><P><V><K><D><R><M><E><M><P><T><A><T><Q><K><T><D><T><G><L><T><Q><G><L><L><K><V><L><H><K><Q><C><H><H><K><R><Y><V><E><L><T><D><L><E><Q><K><W><K><N><L><C><L><P><K><E><K><F><K><A><L><L><Q><L><D><P><C><E><N><K><I><K><W><I><N><F><L><A><L><G><C><S><M><L><G><G><S><L><N><T><A><L><K><H><L><C><E><I><L><T><D><D><P><E><G><G><P><A><R><I><P><F><K><T><F><S><Y><V><Y><R><Y><L><A><R><L><D><S><D><V><S><P><L><E><T><E><S><Y><L><A><S><L><K><E><N><I><D><A><R><K><N><G><M><I><G><L><S><D><F><F><F><P><K><R><K><L><L><E><S><I><E><N><S><E><D><V><G><H>
Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.<BOP>
Q96C74
O43173
SIA8C_HUMAN
Sialyltransferase St8Sia III
Homo
<M><R><N><C><K><M><A><R><V><A><S><V><L><G><L><V><M><L><S><V><A><L><L><I><L><S><L><I><S><Y><V><S><L><K><K><E><N><I><F><T><T><P><K><Y><A><S><P><G><A><P><R><M><Y><M><F><H><A><G><F><R><S><Q><F><A><L><K><F><L><D><P><S><F><V><P><I><T><N><S><L><T><Q><E><L><Q><E><K><P><S><K><W><K><F><N><R><T><A><F><L><H><Q><R><Q><E><I><L><Q><H><V><D><V><I><K><N><F><S><L><T><K><N><S><V><R><I><G><Q><L><M><H><Y><D><Y><S><S><H><K><Y><V><F><S><I><S><N><N><F><R><S><L><L><P><D><V><S><P><I><M><N><K><H><Y><N><I><C><A><V><V><G><N><S><G><I><L><T><G><S><Q><C><G><Q><E><I><D><K><S><D><F><V><F><R><C><N><F><A><P><T><E><A><F><Q><R><D><V><G><R><K><T><N><L><T><T><F><N><P><S><I><L><E><K><Y><Y><N><N><L><L><T><I><Q><D><R><N><N><F><F><L><S><L><K><K><L><D><G><A><I><L><W><I><P><A><F><F><F><H><T><S><A><T><V><T><R><T><L><V><D><F><F><V><E><H><R><G><Q><L><K><V><Q><L><A><W><P><G><N><I><M><Q><H><V><N><R><Y><W><K><N><K><H><L><S><P><K><R><L><S><T><G><I><L><M><Y><T><L><A><S><A><I><C><E><E><I><H><L><Y><G><F><W><P><F><G><F><D><P><N><T><R><E><D><L><P><Y><H><Y><Y><D><K><K><G><T><K><F><T><T><K><W><Q><E><S><H><Q><L><P><A><E><F><Q><L><L><Y><R><M><H><G><E><G><L><T><K><L><T><L><S><H><C><A>
Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.<BOP>
O43173
Q6UXB1
IGFL3_HUMAN
Insulin growth factor-like family member 3
Homo
<M><R><P><R><C><C><I><L><A><L><V><C><W><I><T><V><F><L><L><Q><C><S><K><G><T><T><D><A><P><V><G><S><G><L><W><L><C><Q><P><T><P><R><C><G><N><K><I><Y><N><P><S><E><Q><C><C><Y><D><D><A><I><L><S><L><K><E><T><R><R><C><G><S><T><C><T><F><W><P><C><F><E><L><C><C><P><E><S><F><G><P><Q><Q><K><F><L><V><K><L><R><V><L><G><M><K><S><Q><C><H><L><S><P><I><S><R><S><C><T><R><N><R><R><H><V><L><Y><P>
Potential ligand of the IGFLR1 cell membrane receptor.<BOP>
Q6UXB1
P07195
LDHB_HUMAN
Renal carcinoma antigen NY-REN-46
Homo
<M><A><T><L><K><E><K><L><I><A><P><V><A><E><E><E><A><T><V><P><N><N><K><I><T><V><V><G><V><G><Q><V><G><M><A><C><A><I><S><I><L><G><K><S><L><A><D><E><L><A><L><V><D><V><L><E><D><K><L><K><G><E><M><M><D><L><Q><H><G><S><L><F><L><Q><T><P><K><I><V><A><D><K><D><Y><S><V><T><A><N><S><K><I><V><V><V><T><A><G><V><R><Q><Q><E><G><E><S><R><L><N><L><V><Q><R><N><V><N><V><F><K><F><I><I><P><Q><I><V><K><Y><S><P><D><C><I><I><I><V><V><S><N><P><V><D><I><L><T><Y><V><T><W><K><L><S><G><L><P><K><H><R><V><I><G><S><G><C><N><L><D><S><A><R><F><R><Y><L><M><A><E><K><L><G><I><H><P><S><S><C><H><G><W><I><L><G><E><H><G><D><S><S><V><A><V><W><S><G><V><N><V><A><G><V><S><L><Q><E><L><N><P><E><M><G><T><D><N><D><S><E><N><W><K><E><V><H><K><M><V><V><E><S><A><Y><E><V><I><K><L><K><G><Y><T><N><W><A><I><G><L><S><V><A><D><L><I><E><S><M><L><K><N><L><S><R><I><H><P><V><S><T><M><V><K><G><M><Y><G><I><E><N><E><V><F><L><S><L><P><C><I><L><N><A><R><G><L><T><S><V><I><N><Q><K><L><K><D><D><E><V><A><Q><L><K><K><S><A><D><T><L><W><D><I><Q><K><D><L><K><D><L>
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).<BOP>
P07195
Q86UX7
URP2_HUMAN
Unc-112-related protein 2
Homo
<M><A><G><M><K><T><A><S><G><D><Y><I><D><S><S><W><E><L><R><V><F><V><G><E><E><D><P><E><A><E><S><V><T><L><R><V><T><G><E><S><H><I><G><G><V><L><L><K><I><V><E><Q><I><N><R><K><Q><D><W><S><D><H><A><I><W><W><E><Q><K><R><Q><W><L><L><Q><T><H><W><T><L><D><K><Y><G><I><L><A><D><A><R><L><F><F><G><P><Q><H><R><P><V><I><L><R><L><P><N><R><R><A><L><R><L><R><A><S><F><S><Q><P><L><F><Q><A><V><A><A><I><C><R><L><L><S><I><R><H><P><E><E><L><S><L><L><R><A><P><E><K><K><E><K><K><K><K><E><K><E><P><E><E><E><L><Y><D><L><S><K><V><V><L><A><G><G><V><A><P><A><L><F><R><G><M><P><A><H><F><S><D><S><A><Q><T><E><A><C><Y><H><M><L><S><R><P><Q><P><P><P><D><P><L><L><L><Q><R><L><P><R><P><S><S><L><S><D><K><T><Q><L><H><S><R><W><L><D><S><S><R><C><L><M><Q><Q><G><I><K><A><G><D><A><L><W><L><R><F><K><Y><Y><S><F><F><D><L><D><P><K><T><D><P><V><R><L><T><Q><L><Y><E><Q><A><R><W><D><L><L><L><E><E><I><D><C><T><E><E><E><M><M><V><F><A><A><L><Q><Y><H><I><N><K><L><S><Q><S><G><E><V><G><E><P><A><G><T><D><P><G><L><D><D><L><D><V><A><L><S><N><L><E><V><K><L><E><G><S><A><P><T><D><V><L><D><S><L><T><T><I><P><E><L><K><D><H><L><R><I><F><R><I><P><R><R><P><R><K><L><T><L><K><G><Y><R><Q><H><W><V><V><F><K><E><T><T><L><S><Y><Y><K><S><Q><D><E><A><P><G><D><P><I><Q><Q><L><N><L><K><G><C><E><V><V><P><D><V><N><V><S><G><Q><K><F><C><I><K><L><L><V><P><S><P><E><G><M><S><E><I><Y><L><R><C><Q><D><E><Q><Q><Y><A><R><W><M><A><G><C><R><L><A><S><K><G><R><T><M><A><D><S><S><Y><T><S><E><V><Q><A><I><L><A><F><L><S><L><Q><R><T><G><S><G><G><P><G><N><H><P><H><G><P><D><A><S><A><E><G><L><N><P><Y><G><L><V><A><P><R><F><Q><R><K><F><K><A><K><Q><L><T><P><R><I><L><E><A><H><Q><N><V><A><Q><L><S><L><A><E><A><Q><L><R><F><I><Q><A><W><Q><S><L><P><D><F><G><I><S><Y><V><M><V><R><F><K><G><S><R><K><D><E><I><L><G><I><A><N><N><R><L><I><R><I><D><L><A><V><G><D><V><V><K><T><W><R><F><S><N><M><R><Q><W><N><V><N><W><D><I><R><Q><V><A><I><E><F><D><E><H><I><N><V><A><F><S><C><V><S><A><S><C><R><I><V><H><E><Y><I><G><G><Y><I><F><L><S><T><R><E><R><A><R><G><E><E><L><D><E><D><L><F><L><Q><L><T><G><G><H><E><A><F>
Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.<BOP>
Q86UX7
Q96DG6
CMBL_HUMAN
Carboxymethylenebutenolidase homolog
Homo
<M><A><N><E><A><Y><P><C><P><C><D><I><G><H><R><L><E><Y><G><G><L><G><R><E><V><Q><V><E><H><I><K><A><Y><V><T><K><S><P><V><D><A><G><K><A><V><I><V><I><Q><D><I><F><G><W><Q><L><P><N><T><R><Y><I><A><D><M><I><S><G><N><G><Y><T><T><I><V><P><D><F><F><V><G><Q><E><P><W><D><P><S><G><D><W><S><I><F><P><E><W><L><K><T><R><N><A><Q><K><I><D><R><E><I><S><A><I><L><K><Y><L><K><Q><Q><C><H><A><Q><K><I><G><I><V><G><F><C><W><G><G><T><A><V><H><H><L><M><M><K><Y><S><E><F><R><A><G><V><S><V><Y><G><I><V><K><D><S><E><D><I><Y><N><L><K><N><P><T><L><F><I><F><A><E><N><D><V><V><I><P><L><K><D><V><S><L><L><T><Q><K><L><K><E><H><C><K><V><E><Y><Q><I><K><T><F><S><G><Q><T><H><G><F><V><H><R><K><R><E><D><C><S><P><A><D><K><P><Y><I><D><E><A><R><R><N><L><I><E><W><L><N><K><Y><M>
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.<BOP>
Q96DG6
O95865
DDAH2_HUMAN
S-phase protein
Homo
<M><G><T><P><G><E><G><L><G><R><C><S><H><A><L><I><R><G><V><P><E><S><L><A><S><G><E><G><A><G><A><G><L><P><A><L><D><L><A><K><A><Q><R><E><H><G><V><L><G><G><K><L><R><Q><R><L><G><L><Q><L><L><E><L><P><P><E><E><S><L><P><L><G><P><L><L><G><D><T><A><V><I><Q><G><D><T><A><L><I><T><R><P><W><S><P><A><R><R><P><E><V><D><G><V><R><K><A><L><Q><D><L><G><L><R><I><V><E><I><G><D><E><N><A><T><L><D><G><T><D><V><L><F><T><G><R><E><F><F><V><G><L><S><K><W><T><N><H><R><G><A><E><I><V><A><D><T><F><R><D><F><A><V><S><T><V><P><V><S><G><P><S><H><L><R><G><L><C><G><M><G><G><P><R><T><V><V><A><G><S><S><D><A><A><Q><K><A><V><R><A><M><A><V><L><T><D><H><P><Y><A><S><L><T><L><P><D><D><A><A><A><D><C><L><F><L><R><P><G><L><P><G><V><P><P><F><L><L><H><R><G><G><G><D><L><P><N><S><Q><E><A><L><Q><K><L><S><D><V><T><L><V><P><V><S><C><S><E><L><E><K><A><G><A><G><L><S><S><L><C><L><V><L><S><T><R><P><H><S>
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.<BOP>
O95865
P60228
EIF3E_HUMAN
eIF-3 p48
Homo
<M><A><E><Y><D><L><T><T><R><I><A><H><F><L><D><R><H><L><V><F><P><L><L><E><F><L><S><V><K><E><I><Y><N><E><K><E><L><L><Q><G><K><L><D><L><L><S><D><T><N><M><V><D><F><A><M><D><V><Y><K><N><L><Y><S><D><D><I><P><H><A><L><R><E><K><R><T><T><V><V><A><Q><L><K><Q><L><Q><A><E><T><E><P><I><V><K><M><F><E><D><P><E><T><T><R><Q><M><Q><S><T><R><D><G><R><M><L><F><D><Y><L><A><D><K><H><G><F><R><Q><E><Y><L><D><T><L><Y><R><Y><A><K><F><Q><Y><E><C><G><N><Y><S><G><A><A><E><Y><L><Y><F><F><R><V><L><V><P><A><T><D><R><N><A><L><S><S><L><W><G><K><L><A><S><E><I><L><M><Q><N><W><D><A><A><M><E><D><L><T><R><L><K><E><T><I><D><N><N><S><V><S><S><P><L><Q><S><L><Q><Q><R><T><W><L><I><H><W><S><L><F><V><F><F><N><H><P><K><G><R><D><N><I><I><D><L><F><L><Y><Q><P><Q><Y><L><N><A><I><Q><T><M><C><P><H><I><L><R><Y><L><T><T><A><V><I><T><N><K><D><V><R><K><R><R><Q><V><L><K><D><L><V><K><V><I><Q><Q><E><S><Y><T><Y><K><D><P><I><T><E><F><V><E><C><L><Y><V><N><F><D><F><D><G><A><Q><K><K><L><R><E><C><E><S><V><L><V><N><D><F><F><L><V><A><C><L><E><D><F><I><E><N><A><R><L><F><I><F><E><T><F><C><R><I><H><Q><C><I><S><I><N><M><L><A><D><K><L><N><M><T><P><E><E><A><E><R><W><I><V><N><L><I><R><N><A><R><L><D><A><K><I><D><S><K><L><G><H><V><V><M><G><N><N><A><V><S><P><Y><Q><Q><V><I><E><K><T><K><S><L><S><F><R><S><Q><M><L><A><M><N><I><E><K><K><L><N><Q><N><S><R><S><E><A><P><N><W><A><T><Q><D><S><G><F><Y>
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway . May interact with MCM
P60228
P52823
STC1_HUMAN
Stanniocalcin-1
Homo
<M><L><Q><N><S><A><V><L><L><V><L><V><I><S><A><S><A><T><H><E><A><E><Q><N><D><S><V><S><P><R><K><S><R><V><A><A><Q><N><S><A><E><V><V><R><C><L><N><S><A><L><Q><V><G><C><G><A><F><A><C><L><E><N><S><T><C><D><T><D><G><M><Y><D><I><C><K><S><F><L><Y><S><A><A><K><F><D><T><Q><G><K><A><F><V><K><E><S><L><K><C><I><A><N><G><V><T><S><K><V><F><L><A><I><R><R><C><S><T><F><Q><R><M><I><A><E><V><Q><E><E><C><Y><S><K><L><N><V><C><S><I><A><K><R><N><P><E><A><I><T><E><V><V><Q><L><P><N><H><F><S><N><R><Y><Y><N><R><L><V><R><S><L><L><E><C><D><E><D><T><V><S><T><I><R><D><S><L><M><E><K><I><G><P><N><M><A><S><L><F><H><I><L><Q><T><D><H><C><A><Q><T><H><P><R><A><D><F><N><R><R><R><T><N><E><P><Q><K><L><K><V><L><L><R><N><L><R><G><E><E><D><S><P><S><H><I><K><R><T><S><H><E><S><A>
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.<BOP>
P52823
P11684
UTER_HUMAN
Urinary protein 1
Homo
<M><K><L><A><V><T><L><T><L><V><T><L><A><L><C><C><S><S><A><S><A><E><I><C><P><S><F><Q><R><V><I><E><T><L><L><M><D><T><P><S><S><Y><E><A><A><M><E><L><F><S><P><D><Q><D><M><R><E><A><G><A><Q><L><K><K><L><V><D><T><L><P><Q><K><P><R><E><S><I><I><K><L><M><E><K><I><A><Q><S><S><L><C><N>
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.<BOP>
P11684
Q9NQ34
TMM9B_HUMAN
Transmembrane protein 9B
Homo
<M><A><T><L><W><G><G><L><L><R><L><G><S><L><L><S><L><S><C><L><A><L><S><V><L><L><L><A><Q><L><S><D><A><A><K><N><F><E><D><V><R><C><K><C><I><C><P><P><Y><K><E><N><S><G><H><I><Y><N><K><N><I><S><Q><K><D><C><D><C><L><H><V><V><E><P><M><P><V><R><G><P><D><V><E><A><Y><C><L><R><C><E><C><K><Y><E><E><R><S><S><V><T><I><K><V><T><I><I><I><Y><L><S><I><L><G><L><L><L><L><Y><M><V><Y><L><T><L><V><E><P><I><L><K><R><R><L><F><G><H><A><Q><L><I><Q><S><D><D><D><I><G><D><H><Q><P><F><A><N><A><H><D><V><L><A><R><S><R><S><R><A><N><V><L><N><K><V><E><Y><A><Q><Q><R><W><K><L><Q><V><Q><E><Q><R><K><S><V><F><D><R><H><V><V><L><S>
Enhances production of pro-inflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways.<BOP>
Q9NQ34
Q3MII6
TBC25_HUMAN
TBC1 domain family member 25
Homo
<M><A><T><A><S><G><A><S><D><L><S><G><S><G><A><P><P><P><G><V><G><A><Q><A><A><A><A><A><E><E><E><E><R><E><V><V><R><V><R><V><K><K><C><E><S><F><L><P><P><E><F><R><S><F><A><V><D><P><Q><I><T><S><L><D><V><L><Q><H><I><L><I><R><A><F><D><L><S><G><K><K><N><F><G><I><S><Y><L><G><R><D><R><L><G><Q><E><V><Y><L><S><L><L><S><D><W><D><L><S><T><A><F><A><T><A><S><K><P><Y><L><Q><L><R><V><D><I><R><P><S><E><D><S><P><L><L><E><D><W><D><I><I><S><P><K><D><V><I><G><S><D><V><L><L><A><E><K><R><S><S><L><T><T><A><A><L><P><F><T><Q><S><I><L><T><Q><V><G><R><T><L><S><K><V><Q><Q><V><L><S><W><S><Y><G><E><D><V><K><P><F><K><P><P><L><S><D><A><E><F><H><T><Y><L><N><H><E><G><Q><L><S><R><P><E><E><L><R><L><R><I><Y><H><G><G><V><E><P><S><L><R><K><V><V><W><R><Y><L><L><N><V><Y><P><D><G><L><T><G><R><E><R><M><D><Y><M><K><R><K><S><R><E><Y><E><Q><L><K><S><E><W><A><Q><R><A><N><P><E><D><L><E><F><I><R><S><T><V><L><K><D><V><L><R><T><D><R><A><H><P><Y><Y><A><G><P><E><D><G><P><H><L><R><A><L><H><D><L><L><T><T><Y><A><V><T><H><P><Q><V><S><Y><C><Q><G><M><S><D><L><A><S><P><I><L><A><V><M><D><H><E><G><H><A><F><V><C><F><C><G><I><M><K><R><L><A><A><N><F><H><P><D><G><R><A><M><A><T><K><F><A><H><L><K><L><L><L><R><H><A><D><P><D><F><Y><Q><Y><L><Q><E><A><G><A><D><D><L><F><F><C><Y><R><W><L><L><L><E><L><K><R><E><F><A><F><D><D><A><L><R><M><L><E><V><T><W><S><S><L><P><P><D><P><P><E><H><E><V><E><L><V><G><P><P><S><Q><V><A><D><A><G><F><G><G><H><R><G><W><P><V><R><Q><R><H><M><L><R><P><A><G><G><G><G><S><T><F><E><D><A><V><D><H><L><A><T><A><S><Q><G><P><G><G><G><G><R><L><L><R><Q><A><S><L><D><G><L><Q><Q><L><R><D><N><M><G><S><R><R><D><P><L><V><Q><L><P><H><P><A><A><L><I><S><S><K><S><L><S><E><P><L><L><N><S><P><D><P><L><L><S><S><F><S><H><P><D><S><P><S><S><S><S><P><P><S><T><Q><E><A><S><P><T><G><D><M><A><V><G><S><P><L><M><Q><E><V><G><S><P><K><D><P><G><K><S><L><P><P><V><P><P><M><G><L><P><P><P><Q><E><F><G><R><G><N><P><F><M><L><F><L><C><L><A><I><L><L><E><H><R><D><H><I><M><R><N><G><L><D><Y><N><E><L><A><M><H><F><D><R><L><V><R><K><H><H><L><G><R><V><L><R><R><A><R><A><L><F><A><D><Y><L><Q><S><E><V><W><D><S><E><E><G><A><E><A><T><A><A><S>
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.<BOP>
Q3MII6
Q9H093
NUAK2_HUMAN
SNF1/AMP kinase-related kinase
Homo
<M><E><S><L><V><F><A><R><R><S><G><P><T><P><S><A><A><E><L><A><R><P><L><A><E><G><L><I><K><S><P><K><P><L><M><K><K><Q><A><V><K><R><H><H><H><K><H><N><L><R><H><R><Y><E><F><L><E><T><L><G><K><G><T><Y><G><K><V><K><K><A><R><E><S><S><G><R><L><V><A><I><K><S><I><R><K><D><K><I><K><D><E><Q><D><L><M><H><I><R><R><E><I><E><I><M><S><S><L><N><H><P><H><I><I><A><I><H><E><V><F><E><N><S><S><K><I><V><I><V><M><E><Y><A><S><R><G><D><L><Y><D><Y><I><S><E><R><Q><Q><L><S><E><R><E><A><R><H><F><F><R><Q><I><V><S><A><V><H><Y><C><H><Q><N><R><V><V><H><R><D><L><K><L><E><N><I><L><L><D><A><N><G><N><I><K><I><A><D><F><G><L><S><N><L><Y><H><Q><G><K><F><L><Q><T><F><C><G><S><P><L><Y><A><S><P><E><I><V><N><G><K><P><Y><T><G><P><E><V><D><S><W><S><L><G><V><L><L><Y><I><L><V><H><G><T><M><P><F><D><G><H><D><H><K><I><L><V><K><Q><I><S><N><G><A><Y><R><E><P><P><K><P><S><D><A><C><G><L><I><R><W><L><L><M><V><N><P><T><R><R><A><T><L><E><D><V><A><S><H><W><W><V><N><W><G><Y><A><T><R><V><G><E><Q><E><A><P><H><E><G><G><H><P><G><S><D><S><A><R><A><S><M><A><D><W><L><R><R><S><S><R><P><L><L><E><N><G><A><K><V><C><S><F><F><K><Q><H><A><P><G><G><G><S><T><T><P><G><L><E><R><Q><H><S><L><K><K><S><R><K><E><N><D><M><A><Q><S><L><H><S><D><T><A><D><D><T><A><H><R><P><G><K><S><N><L><K><L><P><K><G><I><L><K><K><K><V><S><A><S><A><E><G><V><Q><E><D><P><P><E><L><S><P><I><P><A><S><P><G><Q><A><A><P><L><L><P><K><K><G><I><L><K><K><P><R><Q><R><E><S><G><Y><Y><S><S><P><E><P><S><E><S><G><E><L><L><D><A><G><D><V><F><V><S><G><D><P><K><E><Q><K><P><P><Q><A><S><G><L><L><L><H><R><K><G><I><L><K><L><N><G><K><F><S><Q><T><A><L><E><L><A><A><P><T><T><F><G><S><L><D><E><L><A><P><P><R><P><L><A><R><A><S><R><P><S><G><A><V><S><E><D><S><I><L><S><S><E><S><F><D><Q><L><D><L><P><E><R><L><P><E><P><P><L><R><G><C><V><S><V><D><N><L><T><G><L><E><E><P><P><S><E><G><P><G><S><C><L><R><R><W><R><Q><D><P><L><G><D><S><C><F><S><L><T><D><C><Q><E><V><T><A><T><Y><R><Q><A><L><R><V><C><S><K><L><T>
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway .<BOP>
Q9H093
Q05996
ZP2_HUMAN
Processed zona pellucida sperm-binding protein 2
Homo
<M><A><C><R><Q><R><G><G><S><W><S><P><S><G><W><F><N><A><G><W><S><T><Y><R><S><I><S><L><F><F><A><L><V><T><S><G><N><S><I><D><V><S><Q><L><V><N><P><A><F><P><G><T><V><T><C><D><E><R><E><I><T><V><E><F><P><S><S><P><G><T><K><K><W><H><A><S><V><V><D><P><L><G><L><D><M><P><N><C><T><Y><I><L><D><P><E><K><L><T><L><R><A><T><Y><D><N><C><T><R><R><V><H><G><G><H><Q><M><T><I><R><V><M><N><N><S><A><A><L><R><H><G><A><V><M><Y><Q><F><F><C><P><A><M><Q><V><E><E><T><Q><G><L><S><A><S><T><I><C><Q><K><D><F><M><S><F><S><L><P><R><V><F><S><G><L><A><D><D><S><K><G><T><K><V><Q><M><G><W><S><I><E><V><G><D><G><A><R><A><K><T><L><T><L><P><E><A><M><K><E><G><F><S><L><L><I><D><N><H><R><M><T><F><H><V><P><F><N><A><T><G><V><T><H><Y><V><Q><G><N><S><H><L><Y><M><V><S><L><K><L><T><F><I><S><P><G><Q><K><V><I><F><S><S><Q><A><I><C><A><P><D><P><V><T><C><N><A><T><H><M><T><L><T><I><P><E><F><P><G><K><L><K><S><V><S><F><E><N><Q><N><I><D><V><S><Q><L><H><D><N><G><I><D><L><E><A><T><N><G><M><K><L><H><F><S><K><T><L><L><K><T><K><L><S><E><K><C><L><L><H><Q><F><Y><L><A><S><L><K><L><T><F><L><L><R><P><E><T><V><S><M><V><I><Y><P><E><C><L><C><E><S><P><V><S><I><V><T><G><E><L><C><T><Q><D><G><F><M><D><V><E><V><Y><S><Y><Q><T><Q><P><A><L><D><L><G><T><L><R><V><G><N><S><S><C><Q><P><V><F><E><A><Q><S><Q><G><L><V><R><F><H><I><P><L><N><G><C><G><T><R><Y><K><F><E><D><D><K><V><V><Y><E><N><E><I><H><A><L><W><T><D><F><P><P><S><K><I><S><R><D><S><E><F><R><M><T><V><K><C><S><Y><S><R><N><D><M><L><L><N><I><N><V><E><S><L><T><P><P><V><A><S><V><K><L><G><P><F><T><L><I><L><Q><S><Y><P><D><N><S><Y><Q><Q><P><Y><G><E><N><E><Y><P><L><V><R><F><L><R><Q><P><I><Y><M><E><V><R><V><L><N><R><D><D><P><N><I><K><L><V><L><D><D><C><W><A><T><S><T><M><D><P><D><S><F><P><Q><W><N><V><V><V><D><G><C><A><Y><D><L><D><N><Y><Q><T><T><F><H><P><V><G><S><S><V><T><H><P><D><H><Y><Q><R><F><D><M><K><A><F><A><F><V><S><E><A><H><V><L><S><S><L><V><Y><F><H><C><S><A><L><I><C><N><R><L><S><P><D><S><P><L><C><S><V><T><C><P><V><S><S><R><H><R><R><A><T><G><A><T><E><A><E><K><M><T><V><S><L><P><G><P><I><L><L><L><S><D><D><S><S><F><R><G><V><G><S><S><D><L><K><A><S><G><S><S><G><E><K><S><R><S><E><T><G><E><E><V><G><S><R><G><A><M><D><T><K><G><H><K><T><A><G><D><V><G><S><K><A><V><A><A><V><A><A><F><A><G><V><V><A><T><L><G><F><I><Y><Y><L><Y><E><K><R><T><V><S><N><H>
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy . The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor .<BOP>
Q05996
A6NHG4
DDTL_HUMAN
D-dopachrome tautomerase-like protein
Homo
<M><P><F><L><E><L><D><T><N><L><P><A><N><R><V><P><A><G><L><E><K><R><L><C><A><A><A><A><S><I><L><G><K><P><A><D><R><V><N><V><T><V><R><P><G><L><A><M><A><L><S><G><S><T><E><P><C><A><Q><L><S><I><S><S><I><G><V><V><G><T><A><E><D><N><R><S><H><S><A><H><F><F><E><F><L><T><K><E><L><A><L><G><Q><D><R><F><P><T><V><L><S><T><S><P><A><A><H><G><G><P><R><C><P><G><E><I><I><E><G><K><K><S><C><L><N><E><E><A><L><F><I><Y><F><I>
May have lyase activity.<BOP>
A6NHG4
Q9UNN8
EPCR_HUMAN
Endothelial cell protein C receptor
Homo
<M><L><T><T><L><L><P><I><L><L><L><S><G><W><A><F><C><S><Q><D><A><S><D><G><L><Q><R><L><H><M><L><Q><I><S><Y><F><R><D><P><Y><H><V><W><Y><Q><G><N><A><S><L><G><G><H><L><T><H><V><L><E><G><P><D><T><N><T><T><I><I><Q><L><Q><P><L><Q><E><P><E><S><W><A><R><T><Q><S><G><L><Q><S><Y><L><L><Q><F><H><G><L><V><R><L><V><H><Q><E><R><T><L><A><F><P><L><T><I><R><C><F><L><G><C><E><L><P><P><E><G><S><R><A><H><V><F><F><E><V><A><V><N><G><S><S><F><V><S><F><R><P><E><R><A><L><W><Q><A><D><T><Q><V><T><S><G><V><V><T><F><T><L><Q><Q><L><N><A><Y><N><R><T><R><Y><E><L><R><E><F><L><E><D><T><C><V><Q><Y><V><Q><K><H><I><S><A><E><N><T><K><G><S><Q><T><S><R><S><Y><T><S><L><V><L><G><V><L><V><G><S><F><I><I><A><G><V><A><V><G><I><F><L><C><T><G><G><R><R><C>
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.<BOP>
Q9UNN8
Q05823
RN5A_HUMAN
Ribonuclease L
Homo
<M><E><S><R><D><H><N><N><P><Q><E><G><P><T><S><S><S><G><R><R><A><A><V><E><D><N><H><L><L><I><K><A><V><Q><N><E><D><V><D><L><V><Q><Q><L><L><E><G><G><A><N><V><N><F><Q><E><E><E><G><G><W><T><P><L><H><N><A><V><Q><M><S><R><E><D><I><V><E><L><L><L><R><H><G><A><D><P><V><L><R><K><K><N><G><A><T><P><F><I><L><A><A><I><A><G><S><V><K><L><L><K><L><F><L><S><K><G><A><D><V><N><E><C><D><F><Y><G><F><T><A><F><M><E><A><A><V><Y><G><K><V><K><A><L><K><F><L><Y><K><R><G><A><N><V><N><L><R><R><K><T><K><E><D><Q><E><R><L><R><K><G><G><A><T><A><L><M><D><A><A><E><K><G><H><V><E><V><L><K><I><L><L><D><E><M><G><A><D><V><N><A><C><D><N><M><G><R><N><A><L><I><H><A><L><L><S><S><D><D><S><D><V><E><A><I><T><H><L><L><L><D><H><G><A><D><V><N><V><R><G><E><R><G><K><T><P><L><I><L><A><V><E><K><K><H><L><G><L><V><Q><R><L><L><E><Q><E><H><I><E><I><N><D><T><D><S><D><G><K><T><A><L><L><L><A><V><E><L><K><L><K><K><I><A><E><L><L><C><K><R><G><A><S><T><D><C><G><D><L><V><M><T><A><R><R><N><Y><D><H><S><L><V><K><V><L><L><S><H><G><A><K><E><D><F><H><P><P><A><E><D><W><K><P><Q><S><S><H><W><G><A><A><L><K><D><L><H><R><I><Y><R><P><M><I><G><K><L><K><F><F><I><D><E><K><Y><K><I><A><D><T><S><E><G><G><I><Y><L><G><F><Y><E><K><Q><E><V><A><V><K><T><F><C><E><G><S><P><R><A><Q><R><E><V><S><C><L><Q><S><S><R><E><N><S><H><L><V><T><F><Y><G><S><E><S><H><R><G><H><L><F><V><C><V><T><L><C><E><Q><T><L><E><A><C><L><D><V><H><R><G><E><D><V><E><N><E><E><D><E><F><A><R><N><V><L><S><S><I><F><K><A><V><Q><E><L><H><L><S><C><G><Y><T><H><Q><D><L><Q><P><Q><N><I><L><I><D><S><K><K><A><A><H><L><A><D><F><D><K><S><I><K><W><A><G><D><P><Q><E><V><K><R><D><L><E><D><L><G><R><L><V><L><Y><V><V><K><K><G><S><I><S><F><E><D><L><K><A><Q><S><N><E><E><V><V><Q><L><S><P><D><E><E><T><K><D><L><I><H><R><L><F><H><P><G><E><H><V><R><D><C><L><S><D><L><L><G><H><P><F><F><W><T><W><E><S><R><Y><R><T><L><R><N><V><G><N><E><S><D><I><K><T><R><K><S><E><S><E><I><L><R><L><L><Q><P><G><P><S><E><H><S><K><S><F><D><K><W><T><T><K><I><N><E><C><V><M><K><K><M><N><K><F><Y><E><K><R><G><N><F><Y><Q><N><T><V><G><D><L><L><K><F><I><R><N><L><G><E><H><I><D><E><E><K><H><K><K><M><K><L><K><I><G><D><P><S><L><Y><F><Q><K><T><F><P><D><L><V><I><Y><V><Y><T><K><L><Q><N><T><E><Y><R><K><H><F><P><Q><T><H><S><P><N><K><P><Q><C><D><G><A><G><G><A><S><G><L><A><S><P><G><C>
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis . Might play a central role in the regulation of mRNA turnover . Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.<BOP>
Q05823
P34896
GLYC_HUMAN
Serine methylase
Homo
<M><T><M><P><V><N><G><A><H><K><D><A><D><L><W><S><S><H><D><K><M><L><A><Q><P><L><K><D><S><D><V><E><V><Y><N><I><I><K><K><E><S><N><R><Q><R><V><G><L><E><L><I><A><S><E><N><F><A><S><R><A><V><L><E><A><L><G><S><C><L><N><N><K><Y><S><E><G><Y><P><G><Q><R><Y><Y><G><G><T><E><F><I><D><E><L><E><T><L><C><Q><K><R><A><L><Q><A><Y><K><L><D><P><Q><C><W><G><V><N><V><Q><P><Y><S><G><S><P><A><N><F><A><V><Y><T><A><L><V><E><P><H><G><R><I><M><G><L><D><L><P><D><G><G><H><L><T><H><G><F><M><T><D><K><K><K><I><S><A><T><S><I><F><F><E><S><M><P><Y><K><V><N><P><D><T><G><Y><I><N><Y><D><Q><L><E><E><N><A><R><L><F><H><P><K><L><I><I><A><G><T><S><C><Y><S><R><N><L><E><Y><A><R><L><R><K><I><A><D><E><N><G><A><Y><L><M><A><D><M><A><H><I><S><G><L><V><A><A><G><V><V><P><S><P><F><E><H><C><H><V><V><T><T><T><T><H><K><T><L><R><G><C><R><A><G><M><I><F><Y><R><K><G><V><K><S><V><D><P><K><T><G><K><E><I><L><Y><N><L><E><S><L><I><N><S><A><V><F><P><G><L><Q><G><G><P><H><N><H><A><I><A><G><V><A><V><A><L><K><Q><A><M><T><L><E><F><K><V><Y><Q><H><Q><V><V><A><N><C><R><A><L><S><E><A><L><T><E><L><G><Y><K><I><V><T><G><G><S><D><N><H><L><I><L><V><D><L><R><S><K><G><T><D><G><G><R><A><E><K><V><L><E><A><C><S><I><A><C><N><K><N><T><C><P><G><D><R><S><A><L><R><P><S><G><L><R><L><G><T><P><A><L><T><S><R><G><L><L><E><K><D><F><Q><K><V><A><H><F><I><H><R><G><I><E><L><T><L><Q><I><Q><S><D><T><G><V><R><A><T><L><K><E><F><K><E><R><L><A><G><D><K><Y><Q><A><A><V><Q><A><L><R><E><E><V><E><S><F><A><S><L><F><P><L><P><G><L><P><D><F>
Interconversion of serine and glycine .<BOP>
P34896
Q96EQ0
SGTB_HUMAN
Small glutamine-rich protein with tetratricopeptide repeats 2
Homo
<M><S><S><I><K><H><L><V><Y><A><V><I><R><F><L><R><E><Q><S><Q><M><D><T><Y><T><S><D><E><Q><E><S><L><E><V><A><I><Q><C><L><E><T><V><F><K><I><S><P><E><D><T><H><L><A><V><S><Q><P><L><T><E><M><F><T><S><S><F><C><K><N><D><V><L><P><L><S><N><S><V><P><E><D><V><G><K><A><D><Q><L><K><D><E><G><N><N><H><M><K><E><E><N><Y><A><A><A><V><D><C><Y><T><Q><A><I><E><L><D><P><N><N><A><V><Y><Y><C><N><R><A><A><A><Q><S><K><L><G><H><Y><T><D><A><I><K><D><C><E><K><A><I><A><I><D><S><K><Y><S><K><A><Y><G><R><M><G><L><A><L><T><A><L><N><K><F><E><E><A><V><T><S><Y><Q><K><A><L><D><L><D><P><E><N><D><S><Y><K><S><N><L><K><I><A><E><Q><K><L><R><E><V><S><S><P><T><G><T><G><L><S><F><D><M><A><S><L><I><N><N><P><A><F><I><S><M><A><A><S><L><M><Q><N><P><Q><V><Q><Q><L><M><S><G><M><M><T><N><A><I><G><G><P><A><A><G><V><G><G><L><T><D><L><S><S><L><I><Q><A><G><Q><Q><F><A><Q><Q><I><Q><Q><Q><N><P><E><L><I><E><Q><L><R><N><H><I><R><S><R><S><F><S><S><S><A><E><E><H><S>
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.<BOP>
Q96EQ0
O75792
RNH2A_HUMAN
Ribonuclease HI subunit A
Homo
<M><D><L><S><E><L><E><R><D><N><T><G><R><C><R><L><S><S><P><V><P><A><V><C><R><K><E><P><C><V><L><G><V><D><E><A><G><R><G><P><V><L><G><P><M><V><Y><A><I><C><Y><C><P><L><P><R><L><A><D><L><E><A><L><K><V><A><D><S><K><T><L><L><E><S><E><R><E><R><L><F><A><K><M><E><D><T><D><F><V><G><W><A><L><D><V><L><S><P><N><L><I><S><T><S><M><L><G><R><V><K><Y><N><L><N><S><L><S><H><D><T><A><T><G><L><I><Q><Y><A><L><D><Q><G><V><N><V><T><Q><V><F><V><D><T><V><G><M><P><E><T><Y><Q><A><R><L><Q><Q><S><F><P><G><I><E><V><T><V><K><A><K><A><D><A><L><Y><P><V><V><S><A><A><S><I><C><A><K><V><A><R><D><Q><A><V><K><K><W><Q><F><V><E><K><L><Q><D><L><D><T><D><Y><G><S><G><Y><P><N><D><P><K><T><K><A><W><L><K><E><H><V><E><P><V><F><G><F><P><Q><F><V><R><F><S><W><R><T><A><Q><T><I><L><E><K><E><A><E><D><V><I><W><E><D><S><A><S><E><N><Q><E><G><L><R><K><I><T><S><Y><F><L><N><E><G><S><Q><A><R><P><R><S><S><H><R><Y><F><L><E><R><G><L><E><S><A><T><S><L>
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.<BOP>
O75792
Q15517
CDSN_HUMAN
S protein
Homo
<M><G><S><S><R><A><P><W><M><G><R><V><G><G><H><G><M><M><A><L><L><L><A><G><L><L><L><P><G><T><L><A><K><S><I><G><T><F><S><D><P><C><K><D><P><T><R><I><T><S><P><N><D><P><C><L><T><G><K><G><D><S><S><G><F><S><S><Y><S><G><S><S><S><S><G><S><S><I><S><S><A><R><S><S><G><G><G><S><S><G><S><S><S><G><S><S><I><A><Q><G><G><S><A><G><S><F><K><P><G><T><G><Y><S><Q><V><S><Y><S><S><G><S><G><S><S><L><Q><G><A><S><G><S><S><Q><L><G><S><S><S><S><H><S><G><N><S><G><S><H><S><G><S><S><S><S><H><S><S><S><S><S><S><F><Q><F><S><S><S><S><F><Q><V><G><N><G><S><A><L><P><T><N><D><N><S><Y><R><G><I><L><N><P><S><Q><P><G><Q><S><S><S><S><S><Q><T><S><G><V><S><S><S><G><Q><S><V><S><S><N><Q><R><P><C><S><S><D><I><P><D><S><P><C><S><G><G><P><I><V><S><H><S><G><P><Y><I><P><S><S><H><S><V><S><G><G><Q><R><P><V><V><V><V><V><D><Q><H><G><S><G><A><P><G><V><V><Q><G><P><P><C><S><N><G><G><L><P><G><K><P><C><P><P><I><T><S><V><D><K><S><Y><G><G><Y><E><V><V><G><G><S><S><D><S><Y><L><V><P><G><M><T><Y><S><K><G><K><I><Y><P><V><G><Y><F><T><K><E><N><P><V><K><G><S><P><G><V><P><S><F><A><A><G><P><P><I><S><E><G><K><Y><F><S><S><N><P><I><I><P><S><Q><S><A><A><S><S><A><I><A><F><Q><P><V><G><T><G><G><V><Q><L><C><G><G><G><S><T><G><S><K><G><P><C><S><P><S><S><S><R><V><P><S><S><S><S><I><S><S><S><S><G><S><P><Y><H><P><C><G><S><A><S><Q><S><P><C><S><P><P><G><T><G><S><F><S><S><S><S><S><S><Q><S><S><G><K><I><I><L><Q><P><C><G><S><K><S><S><S><S><G><H><P><C><M><S><V><S><S><L><T><L><T><G><G><P><D><G><S><P><H><P><D><P><S><A><G><A><K><P><C><G><S><S><S><A><G><K><I><P><C><R><S><I><R><D><I><L><A><Q><V><K><P><L><G><P><Q><L><A><D><P><E><V><F><L><P><Q><G><E><L><L><D><S><P>
Important for the epidermal barrier integrity.<BOP>
Q15517
Q8NGZ6
OR6F1_HUMAN
Olfactory receptor OR1-38
Homo
<M><D><T><G><N><K><T><L><P><Q><D><F><L><L><L><G><F><P><G><S><Q><T><L><Q><L><S><L><F><M><L><F><L><V><M><Y><I><L><T><V><S><G><N><V><A><I><L><M><L><V><S><T><S><H><Q><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><L><E><I><W><Y><T><T><A><A><V><P><K><A><L><A><I><L><L><G><R><S><Q><T><I><S><F><T><S><C><L><L><Q><M><Y><F><V><F><S><L><G><C><T><E><Y><F><L><L><A><A><M><A><Y><D><R><C><L><A><I><C><Y><P><L><H><Y><G><A><I><M><S><S><L><L><S><A><Q><L><A><L><G><S><W><V><C><G><F><V><A><I><A><V><P><T><A><L><I><S><G><L><S><F><C><G><P><R><A><I><N><H><F><F><C><D><I><A><P><W><I><A><L><A><C><T><N><T><Q><A><V><E><L><V><A><F><V><I><A><V><V><V><I><L><S><S><C><L><I><T><F><V><S><Y><V><Y><I><I><S><T><I><L><R><I><P><S><A><S><G><R><S><K><A><F><S><T><C><S><S><H><L><T><V><V><L><I><W><Y><G><S><T><V><F><L><H><V><R><T><S><I><K><D><A><L><D><L><I><K><A><V><H><V><L><N><T><V><V><T><P><V><L><N><P><F><I><Y><T><L><R><N><K><E><V><R><E><T><L><L><K><K><W><K><G><K>
Odorant receptor.<BOP>
Q8NGZ6
Q9Y543
HES2_HUMAN
Hairy and enhancer of split 2
Homo
<M><G><L><P><R><R><A><G><D><A><A><E><L><R><K><S><L><K><P><L><L><E><K><R><R><R><A><R><I><N><Q><S><L><S><Q><L><K><G><L><I><L><P><L><L><G><R><E><N><S><N><C><S><K><L><E><K><A><D><V><L><E><M><T><V><R><F><L><Q><E><L><P><A><S><S><W><P><T><A><A><P><L><P><C><D><S><Y><R><E><G><Y><S><A><C><V><A><R><L><A><R><V><L><P><A><C><R><V><L><E><P><A><V><S><A><R><L><L><E><H><L><W><R><R><A><A><S><A><T><L><D><G><G><R><A><G><D><S><S><G><P><S><A><P><A><P><A><P><A><S><A><P><E><P><A><S><A><P><V><P><S><P><P><S><P><P><C><G><P><G><L><W><R><P><W>
Transcriptional repressor of genes that require a bHLH protein for their transcription.<BOP>
Q9Y543
O95045
UPP2_HUMAN
Uridine phosphorylase 2
Homo
<M><A><S><V><I><P><A><S><N><R><S><M><R><S><D><R><N><T><Y><V><G><K><R><F><V><H><V><K><N><P><Y><L><D><L><M><D><E><D><I><L><Y><H><L><D><L><G><T><K><T><H><N><L><P><A><M><F><G><D><V><K><F><V><C><V><G><G><S><P><N><R><M><K><A><F><A><L><F><M><H><K><E><L><G><F><E><E><A><E><E><D><I><K><D><I><C><A><G><T><D><R><Y><C><M><Y><K><T><G><P><V><L><A><I><S><H><G><M><G><I><P><S><I><S><I><M><L><H><E><L><I><K><L><L><H><H><A><R><C><C><D><V><T><I><I><R><I><G><T><S><G><G><I><G><I><A><P><G><T><V><V><I><T><D><I><A><V><D><S><F><F><K><P><R><F><E><Q><V><I><L><D><N><I><V><T><R><S><T><E><L><D><K><E><L><S><E><E><L><F><N><C><S><K><E><I><P><N><F><P><T><L><V><G><H><T><M><C><T><Y><D><F><Y><E><G><Q><G><R><L><D><G><A><L><C><S><F><S><R><E><K><K><L><D><Y><L><K><R><A><F><K><A><G><V><R><N><I><E><M><E><S><T><V><F><A><A><M><C><G><L><C><G><L><K><A><A><V><V><C><V><T><L><L><D><R><L><D><C><D><Q><I><N><L><P><H><D><V><L><V><E><Y><Q><Q><R><P><Q><L><L><I><S><N><F><I><R><R><R><L><G><L><C><D>
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate . The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates .<BOP>
O95045
Q8NGX2
O2T35_HUMAN
Olfactory receptor OR1-66
Homo
<M><G><M><E><G><L><L><Q><N><S><T><N><F><V><L><T><G><L><I><T><H><P><A><F><P><G><L><L><F><A><V><V><F><S><I><F><V><V><A><I><T><A><N><L><V><M><I><L><L><I><H><M><D><S><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><I><M><D><T><I><Y><I><C><I><T><V><P><K><M><L><Q><D><L><L><S><K><D><K><T><I><S><F><L><G><C><A><V><Q><I><F><Y><L><T><L><I><G><G><E><F><F><L><L><G><L><M><A><Y><D><R><Y><V><A><V><C><N><P><L><R><Y><P><L><L><M><N><R><R><V><C><L><F><M><V><V><G><S><W><V><G><G><S><L><D><G><F><M><L><T><P><V><T><M><S><F><P><F><C><R><S><R><E><I><N><H><F><F><C><E><I><P><A><V><L><K><L><S><C><T><D><T><S><L><Y><E><T><L><M><Y><A><C><C><V><L><M><L><L><I><P><L><S><V><I><S><V><S><Y><T><H><I><L><L><T><V><H><R><M><N><S><A><E><G><R><R><K><A><F><A><T><C><S><S><H><I><M><V><V><S><V><F><Y><G><A><A><F><Y><T><N><V><L><P><H><S><Y><H><T><P><E><K><D><K><V><V><S><A><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><A><A><A><L><R><K><V><L><G><R><C><G><S><S><Q><S><I><R><V><A><T><V><I><R><K><G>
Odorant receptor.<BOP>
Q8NGX2
P09211
GSTP1_HUMAN
GSTP1-1
Homo
<M><P><P><Y><T><V><V><Y><F><P><V><R><G><R><C><A><A><L><R><M><L><L><A><D><Q><G><Q><S><W><K><E><E><V><V><T><V><E><T><W><Q><E><G><S><L><K><A><S><C><L><Y><G><Q><L><P><K><F><Q><D><G><D><L><T><L><Y><Q><S><N><T><I><L><R><H><L><G><R><T><L><G><L><Y><G><K><D><Q><Q><E><A><A><L><V><D><M><V><N><D><G><V><E><D><L><R><C><K><Y><I><S><L><I><Y><T><N><Y><E><A><G><K><D><D><Y><V><K><A><L><P><G><Q><L><K><P><F><E><T><L><L><S><Q><N><Q><G><G><K><T><F><I><V><G><D><Q><I><S><F><A><D><Y><N><L><L><D><L><L><L><I><H><E><V><L><A><P><G><C><L><D><A><F><P><L><L><S><A><Y><V><G><R><L><S><A><R><P><K><L><K><A><F><L><A><S><P><E><Y><V><N><L><P><I><N><G><N><G><K><Q>
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) . Participates in the formation of novel hepoxilin regioisomers . Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<BOP>
P09211
Q9NX63
MIC19_HUMAN
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
Homo
<M><G><G><T><T><S><T><R><R><V><T><F><E><A><D><E><N><E><N><I><T><V><V><K><G><I><R><L><S><E><N><V><I><D><R><M><K><E><S><S><P><S><G><S><K><S><Q><R><Y><S><G><A><Y><G><A><S><V><S><D><E><E><L><K><R><R><V><A><E><E><L><A><L><E><Q><A><K><K><E><S><E><D><Q><K><R><L><K><Q><A><K><E><L><D><R><E><R><A><A><A><N><E><Q><L><T><R><A><I><L><R><E><R><I><C><S><E><E><E><R><A><K><A><K><H><L><A><R><Q><L><E><E><K><D><R><V><L><K><K><Q><D><A><F><Y><K><E><Q><L><A><R><L><E><E><R><S><S><E><F><Y><R><V><T><T><E><Q><Y><Q><K><A><A><E><E><V><E><A><K><F><K><R><Y><E><S><H><P><V><C><A><D><L><Q><A><K><I><L><Q><C><Y><R><E><N><T><H><Q><T><L><K><C><S><A><L><A><T><Q><Y><M><H><C><V><N><H><A><K><Q><S><M><L><E><K><G><G>
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology .<BOP>
Q9NX63
Q86VX2
COMD7_HUMAN
COMM domain-containing protein 7
Homo
<M><G><R><L><H><C><T><E><D><P><V><P><E><A><V><G><G><D><M><Q><Q><L><N><Q><L><G><A><Q><Q><F><S><A><L><T><E><V><L><F><H><F><L><T><E><P><K><E><V><E><R><F><L><A><Q><L><S><E><F><A><T><T><N><Q><I><S><L><G><S><L><R><S><I><V><K><S><L><L><L><V><P><N><G><A><L><K><K><S><L><T><A><K><Q><V><Q><A><D><F><I><T><L><G><L><S><E><E><K><A><T><Y><F><S><E><K><W><K><Q><N><A><P><T><L><A><R><W><A><I><G><Q><T><L><M><I><N><Q><L><I><D><M><E><W><K><F><G><V><T><S><G><S><S><E><L><E><K><V><G><S><I><F><L><Q><L><K><L><V><V><K><K><G><N><Q><T><E><N><V><Y><I><E><L><T><L><P><Q><F><Y><S><F><L><H><E><M><E><R><V><R><T><S><M><E><C><F><C>
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Associates with the NF-kappa-B complex and suppresses its transcriptional activity .<BOP>
Q86VX2
Q9UBT2
SAE2_HUMAN
Ubiquitin-like modifier-activating enzyme 2
Homo
<M><A><L><S><R><G><L><P><R><E><L><A><E><A><V><A><G><G><R><V><L><V><V><G><A><G><G><I><G><C><E><L><L><K><N><L><V><L><T><G><F><S><H><I><D><L><I><D><L><D><T><I><D><V><S><N><L><N><R><Q><F><L><F><Q><K><K><H><V><G><R><S><K><A><Q><V><A><K><E><S><V><L><Q><F><Y><P><K><A><N><I><V><A><Y><H><D><S><I><M><N><P><D><Y><N><V><E><F><F><R><Q><F><I><L><V><M><N><A><L><D><N><R><A><A><R><N><H><V><N><R><M><C><L><A><A><D><V><P><L><I><E><S><G><T><A><G><Y><L><G><Q><V><T><T><I><K><K><G><V><T><E><C><Y><E><C><H><P><K><P><T><Q><R><T><F><P><G><C><T><I><R><N><T><P><S><E><P><I><H><C><I><V><W><A><K><Y><L><F><N><Q><L><F><G><E><E><D><A><D><Q><E><V><S><P><D><R><A><D><P><E><A><A><W><E><P><T><E><A><E><A><R><A><R><A><S><N><E><D><G><D><I><K><R><I><S><T><K><E><W><A><K><S><T><G><Y><D><P><V><K><L><F><T><K><L><F><K><D><D><I><R><Y><L><L><T><M><D><K><L><W><R><K><R><K><P><P><V><P><L><D><W><A><E><V><Q><S><Q><G><E><E><T><N><A><S><D><Q><Q><N><E><P><Q><L><G><L><K><D><Q><Q><V><L><D><V><K><S><Y><A><R><L><F><S><K><S><I><E><T><L><R><V><H><L><A><E><K><G><D><G><A><E><L><I><W><D><K><D><D><P><S><A><M><D><F><V><T><S><A><A><N><L><R><M><H><I><F><S><M><N><M><K><S><R><F><D><I><K><S><M><A><G><N><I><I><P><A><I><A><T><T><N><A><V><I><A><G><L><I><V><L><E><G><L><K><I><L><S><G><K><I><D><Q><C><R><T><I><F><L><N><K><Q><P><N><P><R><K><K><L><L><V><P><C><A><L><D><P><P><N><P><N><C><Y><V><C><A><S><K><P><E><V><T><V><R><L><N><V><H><K><V><T><V><L><T><L><Q><D><K><I><V><K><E><K><F><A><M><V><A><P><D><V><Q><I><E><D><G><K><G><T><I><L><I><S><S><E><E><G><E><T><E><A><N><N><H><K><K><L><S><E><F><G><I><R><N><G><S><R><L><Q><A><D><D><F><L><Q><D><Y><T><L><L><I><N><I><L><H><S><E><D><L><G><K><D><V><E><F><E><V><V><G><D><A><P><E><K><V><G><P><K><Q><A><E><D><A><A><K><S><I><T><N><G><S><D><D><G><A><Q><P><S><T><S><T><A><Q><E><Q><D><D><V><L><I><V><D><S><D><E><E><D><S><S><N><N><A><D><V><S><E><E><E><R><S><R><K><R><K><L><D><E><K><E><N><L><S><A><K><R><S><R><I><E><Q><K><E><E><L><D><D><V><I><A><L><D>
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<BOP>
Q9UBT2
Q8IY26
PLPP6_HUMAN
Type 1 polyisoprenoid diphosphate phosphatase
Homo
<M><P><S><P><R><R><S><M><E><G><R><P><L><G><V><S><A><S><S><S><S><S><S><P><G><S><P><A><H><G><G><G><G><G><G><S><R><F><E><F><Q><S><L><L><S><S><R><A><T><A><V><D><P><T><C><A><R><L><R><A><S><E><S><P><V><H><R><R><G><S><F><P><L><A><A><A><G><P><S><Q><S><P><A><P><P><L><P><E><E><D><R><M><D><L><N><P><S><F><L><G><I><A><L><R><S><L><L><A><I><D><L><W><L><S><K><K><L><G><V><C><A><G><E><S><S><S><W><G><S><V><R><P><L><M><K><L><L><E><I><S><G><H><G><I><P><W><L><L><G><T><L><Y><C><L><C><R><S><D><S><W><A><G><R><E><V><L><M><N><L><L><F><A><L><L><L><D><L><L><L><V><A><L><I><K><G><L><V><R><R><R><R><P><A><H><N><Q><M><D><M><F><V><T><L><S><V><D><K><Y><S><F><P><S><G><H><A><T><R><A><A><L><M><S><R><F><I><L><N><H><L><V><L><A><I><P><L><R><V><L><V><V><L><W><A><F><V><L><G><L><S><R><V><M><L><G><R><H><N><V><T><D><V><A><F><G><F><F><L><G><Y><M><Q><Y><S><I><V><D><Y><C><W><L><S><P><H><N><A><P><V><L><F><L><L><W><S><Q><R>
Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates . Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation . May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway . May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins . Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols . May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-
Q8IY26
Q8NBI6
XXLT1_HUMAN
UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase
Homo
<M><G><L><L><R><G><G><L><P><C><A><R><A><M><A><R><L><G><A><V><R><S><H><Y><C><A><L><L><L><A><A><A><L><A><V><C><A><F><Y><Y><L><G><S><G><R><E><T><F><S><S><A><T><K><R><L><K><E><A><R><A><G><A><P><A><A><P><S><P><P><A><L><E><L><A><R><G><S><V><A><P><A><P><G><A><K><A><K><S><L><E><G><G><G><A><G><P><V><D><Y><H><L><L><M><M><F><T><K><A><E><H><N><A><A><L><Q><A><K><A><R><V><A><L><R><S><L><L><R><L><A><K><F><E><A><H><E><V><L><N><L><H><F><V><S><E><E><A><S><R><E><V><A><K><G><L><L><R><E><L><L><P><P><A><A><G><F><K><C><K><V><I><F><H><D><V><A><V><L><T><D><K><L><F><P><I><V><E><A><M><Q><K><H><F><S><A><G><L><G><T><Y><Y><S><D><S><I><F><F><L><S><V><A><M><H><Q><I><M><P><K><E><I><L><Q><I><I><Q><L><D><L><D><L><K><F><K><T><N><I><R><E><L><F><E><E><F><D><S><F><L><P><G><A><I><I><G><I><A><R><E><M><Q><P><V><Y><R><H><T><F><W><Q><F><R><H><E><N><P><Q><T><R><V><G><G><P><P><P><E><G><L><P><G><F><N><S><G><V><M><L><L><N><L><E><A><M><R><Q><S><P><L><Y><S><R><L><L><E><P><A><Q><V><Q><Q><L><A><D><K><Y><H><F><R><G><H><L><G><D><Q><D><F><F><T><M><I><G><M><E><H><P><K><L><F><H><V><L><D><C><T><W><N><R><Q><L><C><T><W><W><R><D><H><G><Y><S><D><V><F><E><A><Y><F><R><C><E><G><H><V><K><I><Y><H><G><N><C><N><T><P><I><P><E><D>
Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose . Known targets include Notch proteins and coagulation factors, such as F9 .<BOP>
Q8NBI6