accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q96I34
PP16A_HUMAN
Myosin phosphatase-targeting subunit 3
Homo
<M><A><E><H><L><E><L><L><A><E><M><P><M><V><G><R><M><S><T><Q><E><R><L><K><H><A><Q><K><R><R><A><Q><Q><V><K><M><W><A><Q><A><E><K><E><A><Q><G><K><K><G><P><G><E><R><P><R><K><E><A><A><S><Q><G><L><L><K><Q><V><L><F><P><P><S><V><V><L><L><E><A><A><A><R><N><D><L><E><E><V><R><Q><F><L><G><S><G><V><S><P><D><L><A><N><E><D><G><L><T><A><L><H><Q><C><C><I><D><D><F><R><E><M><V><Q><Q><L><L><E><A><G><A><N><I><N><A><C><D><S><E><C><W><T><P><L><H><A><A><A><T><C><G><H><L><H><L><V><E><L><L><I><A><S><G><A><N><L><L><A><V><N><T><D><G><N><M><P><Y><D><L><C><D><D><E><Q><T><L><D><C><L><E><T><A><M><A><D><R><G><I><T><Q><D><S><I><E><A><A><R><A><V><P><E><L><R><M><L><D><D><I><R><S><R><L><Q><A><G><A><D><L><H><A><P><L><D><H><G><A><T><L><L><H><V><A><A><A><N><G><F><S><E><A><A><A><L><L><L><E><H><R><A><S><L><S><A><K><D><Q><D><G><W><E><P><L><H><A><A><A><Y><W><G><Q><V><P><L><V><E><L><L><V><A><H><G><A><D><L><N><A><K><S><L><M><D><E><T><P><L><D><V><C><G><D><E><E><V><R><A><K><L><L><E><L><K><H><K><H><D><A><L><L><R><A><Q><S><R><Q><R><S><L><L><R><R><R><T><S><S><A><G><S><R><G><K><V><V><R><R><V><S><L><T><Q><R><T><D><L><Y><R><K><Q><H><A><Q><E><A><I><V><W><Q><Q><P><P><P><T><S><P><E><P><P><E><D><N><D><D><R><Q><T><G><A><E><L><R><P><P><P><P><E><E><D><N><P><E><V><V><R><P><H><N><G><R><V><G><G><S><P><V><R><H><L><Y><S><K><R><L><D><R><S><V><S><Y><Q><L><S><P><L><D><S><T><T><P><H><T><L><V><H><D><K><A><H><H><T><L><A><D><L><K><R><Q><R><A><A><A><K><L><Q><R><P><P><P><E><G><P><E><S><P><E><T><A><E><P><G><L><P><G><D><T><V><T><P><Q><P><D><C><G><F><R><A><G><G><D><P><P><L><L><K><L><T><A><P><A><V><E><A><P><V><E><R><R><P><C><C><L><L><M>
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.<BOP>
Q96I34
P01178
NEU1_HUMAN
Neurophysin 1
Homo
<M><A><G><P><S><L><A><C><C><L><L><G><L><L><A><L><T><S><A><C><Y><I><Q><N><C><P><L><G><G><K><R><A><A><P><D><L><D><V><R><K><C><L><P><C><G><P><G><G><K><G><R><C><F><G><P><N><I><C><C><A><E><E><L><G><C><F><V><G><T><A><E><A><L><R><C><Q><E><E><N><Y><L><P><S><P><C><Q><S><G><Q><K><A><C><G><S><G><G><R><C><A><V><L><G><L><C><C><S><P><D><G><C><H><A><D><P><A><C><D><A><E><A><T><F><S><Q><R>
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) .<BOP>
P01178
Q9NNX1
TUFT1_HUMAN
Tuftelin
Homo
<M><N><G><T><R><N><W><C><T><L><V><D><V><H><P><E><D><Q><A><A><G><S><V><D><I><L><R><L><T><L><Q><G><E><L><T><G><D><E><L><E><H><I><A><Q><K><A><G><R><K><T><Y><A><M><V><S><S><H><S><A><G><H><S><L><A><S><E><L><V><E><S><H><D><G><H><E><E><I><I><K><V><Y><L><K><G><R><S><G><D><K><M><I><H><E><K><N><I><N><Q><L><K><S><E><V><Q><Y><I><Q><E><A><R><N><C><L><Q><K><L><R><E><D><I><S><S><K><L><D><R><N><L><G><D><S><L><H><R><Q><E><I><Q><V><V><L><E><K><P><N><G><F><S><Q><S><P><T><A><L><Y><S><S><P><P><E><V><D><T><C><I><N><E><D><V><E><S><L><R><K><T><V><Q><D><L><L><A><K><L><Q><E><A><K><R><Q><H><Q><S><D><C><V><A><F><E><V><T><L><S><R><Y><Q><R><E><A><E><Q><S><N><V><A><L><Q><R><E><E><D><R><V><E><Q><K><E><A><E><V><G><E><L><Q><R><R><L><L><G><M><E><T><E><H><Q><A><L><L><A><K><V><R><E><G><E><V><A><L><E><E><L><R><S><N><N><A><D><C><Q><A><E><R><E><K><A><A><T><L><E><K><E><V><A><G><L><R><E><K><I><H><H><L><D><D><M><L><K><S><Q><Q><R><K><V><R><Q><M><I><E><Q><L><Q><N><S><K><A><V><I><Q><S><K><D><A><T><I><Q><E><L><K><E><K><I><A><Y><L><E><A><E><N><L><E><M><H><D><R><M><E><H><L><I><E><K><Q><I><S><H><G><N><F><S><T><Q><A><R><A><K><T><E><N><P><G><S><I><R><I><S><K><P><P><S><P><K><P><M><P><V><I><R><V><V><E><T>
Involved in the mineralization and structural organization of enamel.<BOP>
Q9NNX1
Q3ZCQ8
TIM50_HUMAN
Mitochondrial import inner membrane translocase subunit TIM50
Homo
<M><A><A><S><A><A><V><F><S><R><L><R><S><G><L><R><L><G><S><R><G><L><C><T><R><L><A><T><P><P><R><R><A><P><D><Q><A><A><E><I><G><S><R><G><S><T><K><A><Q><G><P><Q><Q><Q><P><G><S><E><G><P><S><Y><A><K><K><V><A><L><W><L><A><G><L><L><G><A><G><G><T><V><S><V><V><Y><I><F><G><N><N><P><V><D><E><N><G><A><K><I><P><D><E><F><D><N><D><P><I><L><V><Q><Q><L><R><R><T><Y><K><Y><F><K><D><Y><R><Q><M><I><I><E><P><T><S><P><C><L><L><P><D><P><L><Q><E><P><Y><Y><Q><P><P><Y><T><L><V><L><E><L><T><G><V><L><L><H><P><E><W><S><L><A><T><G><W><R><F><K><K><R><P><G><I><E><T><L><F><Q><Q><L><A><P><L><Y><E><I><V><I><F><T><S><E><T><G><M><T><A><F><P><L><I><D><S><V><D><P><H><G><F><I><S><Y><R><L><F><R><D><A><T><R><Y><M><D><G><H><H><V><K><D><I><S><C><L><N><R><D><P><A><R><V><V><V><V><D><C><K><K><E><A><F><R><L><Q><P><Y><N><G><V><A><L><R><P><W><D><G><N><S><D><D><R><V><L><L><D><L><S><A><F><L><K><T><I><A><L><N><G><V><E><D><V><R><T><V><L><E><H><Y><A><L><E><D><D><P><L><A><A><F><K><Q><R><Q><S><R><L><E><Q><E><E><Q><Q><R><L><A><E><L><S><K><S><N><K><Q><N><L><F><L><G><S><L><T><S><R><L><W><P><R><S><K><Q><P>
May participate in the release of snRNPs and SMN from the Cajal body.<BOP>
Q3ZCQ8
Q70Z44
5HT3D_HUMAN
Serotonin receptor 3D
Homo
<M><Q><K><H><S><P><G><P><P><A><L><A><L><L><S><Q><S><L><L><T><T><G><N><G><D><T><L><I><I><N><C><P><G><F><G><Q><H><R><V><D><P><A><A><F><Q><A><V><F><D><R><K><A><I><G><P><V><T><N><Y><S><V><A><T><H><V><N><I><S><F><T><L><S><A><I><W><N><C><Y><S><R><I><H><T><F><N><C><H><H><A><R><P><W><H><N><Q><F><V><Q><W><N><P><D><E><C><G><G><I><K><K><S><G><M><A><T><E><N><L><W><L><S><D><V><F><I><E><E><S><V><D><Q><T><P><A><G><L><M><A><S><M><S><I><V><K><A><T><S><N><T><I><S><Q><C><G><W><S><A><S><A><N><W><T><P><S><I><S><P><S><M><D><R><A><R><A><W><R><R><M><S><R><S><F><Q><I><H><H><R><T><S><F><R><T><R><R><E><W><V><L><L><G><I><Q><K><R><T><I><K><V><T><V><A><T><N><Q><Y><E><Q><A><I><F><H><V><A><I><R><R><R><C><R><P><S><P><Y><V><V><N><F><L><V><P><S><G><I><L><I><A><I><D><A><L><S><F><Y><L><P><L><E><S><G><N><C><A><P><F><K><M><T><V><L><L><G><Y><S><V><F><L><L><M><M><N><D><L><L><P><A><T><S><T><S><S><H><A><S><L><V><A><P><L><A><L><M><Q><T><P><L><P><A><G><V><Y><F><A><L><C><L><S><L><M><V><G><S><L><L><E><T><I><F><I><T><H><L><L><H><V><A><T><T><Q><P><L><P><L><P><R><W><L><H><S><L><L><L><H><C><T><G><Q><G><R><C><C><P><T><A><P><Q><K><G><N><K><G><P><G><L><T><P><T><H><L><P><G><V><K><E><P><E><V><S><A><G><Q><M><P><G><P><G><E><A><E><L><T><G><G><S><E><W><T><R><A><Q><R><E><H><E><A><Q><K><Q><H><S><V><E><L><W><V><Q><F><S><H><A><M><D><A><L><L><F><R><L><Y><L><L><F><M><A><S><S><I><I><T><V><I><C><L><W><N><T>
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.<BOP>
Q70Z44
O00230
CORT_HUMAN
Cortistatin-17
Homo
<M><P><L><S><P><G><L><L><L><L><L><L><S><G><A><T><A><T><A><A><L><P><L><E><G><G><P><T><G><R><D><S><E><H><M><Q><E><A><A><G><I><R><K><S><S><L><L><T><F><L><A><W><W><F><E><W><T><S><Q><A><S><A><G><P><L><I><G><E><E><A><R><E><V><A><R><R><Q><E><G><A><P><P><Q><Q><S><A><R><R><D><R><M><P><C><R><N><F><F><W><K><T><F><S><S><C><K>
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.<BOP>
O00230
P35611
ADDA_HUMAN
Erythrocyte adducin subunit alpha
Homo
<M><N><G><D><S><R><A><A><V><V><T><S><P><P><P><T><T><A><P><H><K><E><R><Y><F><D><R><V><D><E><N><N><P><E><Y><L><R><E><R><N><M><A><P><D><L><R><Q><D><F><N><M><M><E><Q><K><K><R><V><S><M><I><L><Q><S><P><A><F><C><E><E><L><E><S><M><I><Q><E><Q><F><K><K><G><K><N><P><T><G><L><L><A><L><Q><Q><I><A><D><F><M><T><T><N><V><P><N><V><Y><P><A><A><P><Q><G><G><M><A><A><L><N><M><S><L><G><M><V><T><P><V><N><D><L><R><G><S><D><S><I><A><Y><D><K><G><E><K><L><L><R><C><K><L><A><A><F><Y><R><L><A><D><L><F><G><W><S><Q><L><I><Y><N><H><I><T><T><R><V><N><S><E><Q><E><H><F><L><I><V><P><F><G><L><L><Y><S><E><V><T><A><S><S><L><V><K><I><N><L><Q><G><D><I><V><D><R><G><S><T><N><L><G><V><N><Q><A><G><F><T><L><H><S><A><I><Y><A><A><R><P><D><V><K><C><V><V><H><I><H><T><P><A><G><A><A><V><S><A><M><K><C><G><L><L><P><I><S><P><E><A><L><S><L><G><E><V><A><Y><H><D><Y><H><G><I><L><V><D><E><E><E><K><V><L><I><Q><K><N><L><G><P><K><S><K><V><L><I><L><R><N><H><G><L><V><S><V><G><E><S><V><E><E><A><F><Y><Y><I><H><N><L><V><V><A><C><E><I><Q><V><R><T><L><A><S><A><G><G><P><D><N><L><V><L><L><N><P><E><K><Y><K><A><K><S><R><S><P><G><S><P><V><G><E><G><T><G><S><P><P><K><W><Q><I><G><E><Q><E><F><E><A><L><M><R><M><L><D><N><L><G><Y><R><T><G><Y><P><Y><R><Y><P><A><L><R><E><K><S><K><K><Y><S><D><V><E><V><P><A><S><V><T><G><Y><S><F><A><S><D><G><D><S><G><T><C><S><P><L><R><H><S><F><Q><K><Q><Q><R><E><K><T><R><W><L><N><S><G><R><G><D><E><A><S><E><E><G><Q><N><G><S><S><P><K><S><K><T><K><W><T><K><E><D><G><H><R><T><S><T><S><A><V><P><N><L><F><V><P><L><N><T><N><P><K><E><V><Q><E><M><R><N><K><I><R><E><Q><N><L><Q><D><I><K><T><A><G><P><Q><S><Q><V><L><C><G><V><V><M><D><R><S><L><V><Q><G><E><L><V><T><A><S><K><A><I><I><E><K><E><Y><Q><P><H><V><I><V><S><T><T><G><P><N><P><F><T><T><L><T><D><R><E><L><E><E><Y><R><R><E><V><E><R><K><Q><K><G><S><E><E><N><L><D><E><A><R><E><Q><K><E><K><S><P><P><D><Q><P><A><V><P><H><P><P><P><S><T><P><I><K><L><E><E><D><L><V><P><E><P><T><T><G><D><D><S><D><A><A><T><F><K><P><T><L><P><D><L><S><P><D><E><P><S><E><A><L><G><F><P><M><L><E><K><E><E><E><A><H><R><P><P><S><P><T><E><A><P><T><E><A><S><P><E><P><A><P><D><P><A><P><V><A><E><E><A><A><P><S><A><V><E><E><G><A><A><A><D><P><G><S><D><G><S><P><G><K><S><P><S><K><K><K><K><K><F><R><T><P><S><F><L><K><K><S><K><K><K><S><D><S>
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.<BOP>
P35611
Q9UH99
SUN2_HUMAN
Sad1/unc-84 protein-like 2
Homo
<M><S><R><R><S><Q><R><L><T><R><Y><S><Q><G><D><D><D><G><S><S><S><S><G><G><S><S><V><A><G><S><Q><S><T><L><F><K><D><S><P><L><R><T><L><K><R><K><S><S><N><M><K><R><L><S><P><A><P><Q><L><G><P><S><S><D><A><H><T><S><Y><Y><S><E><S><L><V><H><E><S><W><F><P><P><R><S><S><L><E><E><L><H><G><D><A><N><W><G><E><D><L><R><V><R><R><R><R><G><T><G><G><S><E><S><S><R><A><S><G><L><V><G><R><K><A><T><E><D><F><L><G><S><S><S><G><Y><S><S><E><D><D><Y><V><G><Y><S><D><V><D><Q><Q><S><S><S><S><R><L><R><S><A><V><S><R><A><G><S><L><L><W><M><V><A><T><S><P><G><R><L><F><R><L><L><Y><W><W><A><G><T><T><W><Y><R><L><T><T><A><A><S><L><L><D><V><F><V><L><T><R><R><F><S><S><L><K><T><F><L><W><F><L><L><P><L><L><L><L><T><C><L><T><Y><G><A><W><Y><F><Y><P><Y><G><L><Q><T><F><H><P><A><L><V><S><W><W><A><A><K><D><S><R><R><P><D><E><G><W><E><A><R><D><S><S><P><H><F><Q><A><E><Q><R><V><M><S><R><V><H><S><L><E><R><R><L><E><A><L><A><A><E><F><S><S><N><W><Q><K><E><A><M><R><L><E><R><L><E><L><R><Q><G><A><P><G><Q><G><G><G><G><G><L><S><H><E><D><T><L><A><L><L><E><G><L><V><S><R><R><E><A><A><L><K><E><D><F><R><R><E><T><A><A><R><I><Q><E><E><L><S><A><L><R><A><E><H><Q><Q><D><S><E><D><L><F><K><K><I><V><R><A><S><Q><E><S><E><A><R><I><Q><Q><L><K><S><E><W><Q><S><M><T><Q><E><S><F><Q><E><S><S><V><K><E><L><R><R><L><E><D><Q><L><A><G><L><Q><Q><E><L><A><A><L><A><L><K><Q><S><S><V><A><E><E><V><G><L><L><P><Q><Q><I><Q><A><V><R><D><D><V><E><S><Q><F><P><A><W><I><S><Q><F><L><A><R><G><G><G><G><R><V><G><L><L><Q><R><E><E><M><Q><A><Q><L><R><E><L><E><S><K><I><L><T><H><V><A><E><M><Q><G><K><S><A><R><E><A><A><A><S><L><S><L><T><L><Q><K><E><G><V><I><G><V><T><E><E><Q><V><H><H><I><V><K><Q><A><L><Q><R><Y><S><E><D><R><I><G><L><A><D><Y><A><L><E><S><G><G><A><S><V><I><S><T><R><C><S><E><T><Y><E><T><K><T><A><L><L><S><L><F><G><I><P><L><W><Y><H><S><Q><S><P><R><V><I><L><Q><P><D><V><H><P><G><N><C><W><A><F><Q><G><P><Q><G><F><A><V><V><R><L><S><A><R><I><R><P><T><A><V><T><L><E><H><V><P><K><A><L><S><P><N><S><T><I><S><S><A><P><K><D><F><A><I><F><G><F><D><E><D><L><Q><Q><E><G><T><L><L><G><K><F><T><Y><D><Q><D><G><E><P><I><Q><T><F><H><F><Q><A><P><T><M><A><T><Y><Q><V><V><E><L><R><I><L><T><N><W><G><H><P><E><Y><T><C><I><Y><R><F><R><V><H><G><E><P><A><H>
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome
Q9UH99
P35368
ADA1B_HUMAN
Alpha-1B adrenoreceptor
Homo
<M><N><P><D><L><D><T><G><H><N><T><S><A><P><A><H><W><G><E><L><K><N><A><N><F><T><G><P><N><Q><T><S><S><N><S><T><L><P><Q><L><D><I><T><R><A><I><S><V><G><L><V><L><G><A><F><I><L><F><A><I><V><G><N><I><L><V><I><L><S><V><A><C><N><R><H><L><R><T><P><T><N><Y><F><I><V><N><L><A><M><A><D><L><L><L><S><F><T><V><L><P><F><S><A><A><L><E><V><L><G><Y><W><V><L><G><R><I><F><C><D><I><W><A><A><V><D><V><L><C><C><T><A><S><I><L><S><L><C><A><I><S><I><D><R><Y><I><G><V><R><Y><S><L><Q><Y><P><T><L><V><T><R><R><K><A><I><L><A><L><L><S><V><W><V><L><S><T><V><I><S><I><G><P><L><L><G><W><K><E><P><A><P><N><D><D><K><E><C><G><V><T><E><E><P><F><Y><A><L><F><S><S><L><G><S><F><Y><I><P><L><A><V><I><L><V><M><Y><C><R><V><Y><I><V><A><K><R><T><T><K><N><L><E><A><G><V><M><K><E><M><S><N><S><K><E><L><T><L><R><I><H><S><K><N><F><H><E><D><T><L><S><S><T><K><A><K><G><H><N><P><R><S><S><I><A><V><K><L><F><K><F><S><R><E><K><K><A><A><K><T><L><G><I><V><V><G><M><F><I><L><C><W><L><P><F><F><I><A><L><P><L><G><S><L><F><S><T><L><K><P><P><D><A><V><F><K><V><V><F><W><L><G><Y><F><N><S><C><L><N><P><I><I><Y><P><C><S><S><K><E><F><K><R><A><F><V><R><I><L><G><C><Q><C><R><G><R><G><R><R><R><R><R><R><R><R><R><L><G><G><C><A><Y><T><Y><R><P><W><T><R><G><G><S><L><E><R><S><Q><S><R><K><D><S><L><D><D><S><G><S><C><L><S><G><S><Q><R><T><L><P><S><A><S><P><S><P><G><Y><L><G><R><G><A><P><P><P><V><E><L><C><A><F><P><E><W><K><A><P><G><A><L><L><S><L><P><A><P><E><P><P><G><R><R><G><R><H><D><S><G><P><L><F><T><F><K><L><L><T><E><P><E><S><P><G><T><D><G><G><A><S><N><G><G><C><E><A><A><A><D><V><A><N><G><Q><P><G><F><K><S><N><M><P><L><A><P><G><Q><F>
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.<BOP>
P35368
Q92503
S14L1_HUMAN
SEC14-like protein 1
Homo
<M><V><Q><K><Y><Q><S><P><V><R><V><Y><K><Y><P><F><E><L><I><M><A><A><Y><E><R><R><F><P><T><C><P><L><I><P><M><F><V><G><S><D><T><V><N><E><F><K><S><E><D><G><A><I><H><V><I><E><R><R><C><K><L><D><V><D><A><P><R><L><L><K><K><I><A><G><V><D><Y><V><Y><F><V><Q><K><N><S><L><N><S><R><E><R><T><L><H><I><E><A><Y><N><E><T><F><S><N><R><V><I><I><N><E><H><C><C><Y><T><V><H><P><E><N><E><D><W><T><C><F><E><Q><S><A><S><L><D><I><K><S><F><F><G><F><E><S><T><V><E><K><I><A><M><K><Q><Y><T><S><N><I><K><K><G><K><E><I><I><E><Y><Y><L><R><Q><L><E><E><E><G><I><T><F><V><P><R><W><S><P><P><S><I><T><T><S><S><E><T><S><S><S><S><S><K><K><Q><A><A><S><M><A><V><V><I><P><E><A><A><L><K><E><G><L><S><G><D><A><L><S><S><P><S><A><P><E><P><V><V><G><T><P><D><D><K><L><D><A><D><Y><I><K><R><Y><L><G><D><L><T><P><L><Q><E><S><C><L><I><R><L><R><Q><W><L><Q><E><T><H><K><G><K><I><P><K><D><E><H><I><L><R><F><L><R><A><R><D><F><N><I><D><K><A><R><E><I><M><C><Q><S><L><T><W><R><K><Q><H><Q><V><D><Y><I><L><E><T><W><T><P><P><Q><V><L><Q><D><Y><Y><A><G><G><W><H><H><H><D><K><D><G><R><P><L><Y><V><L><R><L><G><Q><M><D><T><K><G><L><V><R><A><L><G><E><E><A><L><L><R><Y><V><L><S><I><N><E><E><G><L><R><R><C><E><E><N><T><K><V><F><G><R><P><I><S><S><W><T><C><L><V><D><L><E><G><L><N><M><R><H><L><W><R><P><G><V><K><A><L><L><R><I><I><E><V><V><E><A><N><Y><P><E><T><L><G><R><L><L><I><L><R><A><P><R><V><F><P><V><L><W><T><L><V><S><P><F><I><D><D><N><T><R><R><K><F><L><I><Y><A><G><N><D><Y><Q><G><P><G><G><L><L><D><Y><I><D><K><E><I><I><P><D><F><L><S><G><E><C><M><C><E><V><P><E><G><G><L><V><P><K><S><L><Y><R><T><A><E><E><L><E><N><E><D><L><K><L><W><T><E><T><I><Y><Q><S><A><S><V><F><K><G><A><P><H><E><I><L><I><Q><I><V><D><A><S><S><V><I><T><W><D><F><D><V><C><K><G><D><I><V><F><N><I><Y><H><S><K><R><S><P><Q><P><P><K><K><D><S><L><G><A><H><S><I><T><S><P><G><G><N><N><V><Q><L><I><D><K><V><W><Q><L><G><R><D><Y><S><M><V><E><S><P><L><I><C><K><E><G><E><S><V><Q><G><S><H><V><T><R><W><P><G><F><Y><I><L><Q><W><K><F><H><S><M><P><A><C><A><A><S><S><L><P><R><V><D><D><V><L><A><S><L><Q><V><S><S><H><K><C><K><V><M><Y><Y><T><E><V><I><G><S><E><D><F><R><G><S><M><T><S><L><E><S><S><H><S><G><F><S><Q><L><S><A><A><T><T><S><S><S><Q><S><H><S><S><S><M><I><S><R>
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation . May also regulate the SLC18A3 and SLC5A7 cholinergic transporters .<BOP>
Q92503
O94923
GLCE_HUMAN
Heparosan-N-sulfate-glucuronate 5-epimerase
Homo
<M><R><C><L><A><A><R><V><N><Y><K><T><L><I><I><I><C><A><L><F><T><L><V><T><V><L><L><W><N><K><C><S><S><D><K><A><I><Q><F><P><R><R><S><S><S><G><F><R><V><D><G><F><E><K><R><A><A><A><S><E><S><N><N><Y><M><N><H><V><A><K><Q><Q><S><E><E><A><F><P><Q><E><Q><Q><K><A><P><P><V><V><G><G><F><N><S><N><V><G><S><K><V><L><G><L><K><Y><E><E><I><D><C><L><I><N><D><E><H><T><I><K><G><R><R><E><G><N><E><V><F><L><P><F><T><W><V><E><K><Y><F><D><V><Y><G><K><V><V><Q><Y><D><G><Y><D><R><F><E><F><S><H><S><Y><S><K><V><Y><A><Q><R><A><P><Y><H><P><D><G><V><F><M><S><F><E><G><Y><N><V><E><V><R><D><R><V><K><C><I><S><G><V><E><G><V><P><L><S><T><Q><W><G><P><Q><G><Y><F><Y><P><I><Q><I><A><Q><Y><G><L><S><H><Y><S><K><N><L><T><E><K><P><P><H><I><E><V><Y><E><T><A><E><D><R><D><K><N><K><P><N><D><W><T><V><P><K><G><C><F><M><A><N><V><A><D><K><S><R><F><T><N><V><K><Q><F><I><A><P><E><T><S><E><G><V><S><L><Q><L><G><N><T><K><D><F><I><I><S><F><D><L><K><F><L><T><N><G><S><V><S><V><V><L><E><T><T><E><K><N><Q><L><F><T><I><H><Y><V><S><N><A><Q><L><I><A><F><K><E><R><D><I><Y><Y><G><I><G><P><R><T><S><W><S><T><V><T><R><D><L><V><T><D><L><R><K><G><V><G><L><S><N><T><K><A><V><K><P><T><K><I><M><P><K><K><V><V><R><L><I><A><K><G><K><G><F><L><D><N><I><T><I><S><T><T><A><H><M><A><A><F><F><A><A><S><D><W><L><V><R><N><Q><D><E><K><G><G><W><P><I><M><V><T><R><K><L><G><E><G><F><K><S><L><E><P><G><W><Y><S><A><M><A><Q><G><Q><A><I><S><T><L><V><R><A><Y><L><L><T><K><D><H><I><F><L><N><S><A><L><R><A><T><A><P><Y><K><F><L><S><E><Q><H><G><V><K><A><V><F><M><N><K><H><D><W><Y><E><E><Y><P><T><T><P><S><S><F><V><L><N><G><F><M><Y><S><L><I><G><L><Y><D><L><K><E><T><A><G><E><K><L><G><K><E><A><R><S><L><Y><E><R><G><M><E><S><L><K><A><M><L><P><L><Y><D><T><G><S><G><T><I><Y><D><L><R><H><F><M><L><G><I><A><P><N><L><A><R><W><D><Y><H><T><T><H><I><N><Q><L><Q><L><L><S><T><I><D><E><S><P><V><F><K><E><F><V><K><R><W><K><S><Y><L><K><G><S><R><A><K><H><N>
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.<BOP>
O94923
O75493
CAH11_HUMAN
Carbonic anhydrase-related protein 2
Homo
<M><G><A><A><A><R><L><S><A><P><R><A><L><V><L><W><A><A><L><G><A><A><A><H><I><G><P><A><P><D><P><E><D><W><W><S><Y><K><D><N><L><Q><G><N><F><V><P><G><P><P><F><W><G><L><V><N><A><A><W><S><L><C><A><V><G><K><R><Q><S><P><V><D><V><E><L><K><R><V><L><Y><D><P><F><L><P><P><L><R><L><S><T><G><G><E><K><L><R><G><T><L><Y><N><T><G><R><H><V><S><F><L><P><A><P><R><P><V><V><N><V><S><G><G><P><L><L><Y><S><H><R><L><S><E><L><R><L><L><F><G><A><R><D><G><A><G><S><E><H><Q><I><N><H><Q><G><F><S><A><E><V><Q><L><I><H><F><N><Q><E><L><Y><G><N><F><S><A><A><S><R><G><P><N><G><L><A><I><L><S><L><F><V><N><V><A><S><T><S><N><P><F><L><S><R><L><L><N><R><D><T><I><T><R><I><S><Y><K><N><D><A><Y><F><L><Q><D><L><S><L><E><L><L><F><P><E><S><F><G><F><I><T><Y><Q><G><S><L><S><T><P><P><C><S><E><T><V><T><W><I><L><I><D><R><A><L><N><I><T><S><L><Q><M><H><S><L><R><L><L><S><Q><N><P><P><S><Q><I><F><Q><S><L><S><G><N><S><R><P><L><Q><P><L><A><H><R><A><L><R><G><N><R><D><P><R><H><P><E><R><R><C><R><G><P><N><Y><R><L><H><V><D><G><V><P><H><G><R>
Does not have a catalytic activity.<BOP>
O75493
Q7L2R6
ZN765_HUMAN
Zinc finger protein 765
Homo
<M><A><L><P><Q><G><L><L><T><F><R><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><D><I><S><S><K><C><M><M><K><E><F><S><S><T><A><Q><G><N><R><E><V><F><H><A><G><T><S><Q><R><H><E><S><H><H><N><G><D><F><C><F><Q><D><I><D><K><D><I><H><D><I><E><F><Q><W><Q><E><D><E><R><N><G><H><E><A><L><M><T><K><I><K><K><L><T><G><S><T><E><R><Y><D><Q><N><Y><A><G><N><K><P><V><K><Y><Q><L><G><F><S><F><H><S><H><L><P><E><L><H><I><F><H><T><E><E><K><I><D><N><Q><V><V><K><S><I><H><D><A><S><L><V><S><T><A><Q><R><I><S><C><R><P><E><T><H><I><S><N><D><Y><G><N><N><F><L><N><S><S><L><F><T><Q><K><Q><E><V><H><M><R><E><K><S><F><Q><C><N><D><S><G><K><A><Y><N><C><S><S><L><L><R><K><H><Q><L><I><H><L><G><E><K><Q><Y><K><C><D><I><C><G><K><V><F><N><S><K><R><Y><V><A><R><H><R><R><C><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><S><Q><T><Y><Y><L><T><C><H><R><R><L><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><A><F><H><F><K><S><K><L><Q><I><H><R><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><S><Q><K><S><Y><L><T><C><H><R><R><L><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><S><R><K><S><H><F><T><C><H><H><R><V><H><T><G><E><K><P><Y><K><C><N><E><C><S><K><T><F><S><H><K><S><S><L><T><Y><H><R><R><L><H><T><E><E><K><P><Y><K><C><N><E><C><G><K><T><F><N><Q><Q><L><T><L><N><I><C><R><L><H><S><G><E><K><P><Y><K><C><E><E><C><D><K><A><Y><S><F><K><S><N><L><E><I><H><Q><K><I><H><T><E><E><N><P><Y><K><C><N><E><C><G><K><T><F><S><R><T><S><S><L><T><Y><H><H><R><L><H><T><G><Q><K><P><Y><K><C><E><D><C><D><E><A><F><S><F><K><S><N><L><E><R><H><R><R><I><Y><T><G><E><K><L><H><V>
May be involved in transcriptional regulation.<BOP>
Q7L2R6
Q96LA6
FCRL1_HUMAN
Immune receptor translocation-associated protein 5
Homo
<M><L><P><R><L><L><L><L><I><C><A><P><L><C><E><P><A><E><L><F><L><I><A><S><P><S><H><P><T><E><G><S><P><V><T><L><T><C><K><M><P><F><L><Q><S><S><D><A><Q><F><Q><F><C><F><F><R><D><T><R><A><L><G><P><G><W><S><S><S><P><K><L><Q><I><A><A><M><W><K><E><D><T><G><S><Y><W><C><E><A><Q><T><M><A><S><K><V><L><R><S><R><R><S><Q><I><N><V><H><R><V><P><V><A><D><V><S><L><E><T><Q><P><P><G><G><Q><V><M><E><G><D><R><L><V><L><I><C><S><V><A><M><G><T><G><D><I><T><F><L><W><Y><K><G><A><V><G><L><N><L><Q><S><K><T><Q><R><S><L><T><A><E><Y><E><I><P><S><V><R><E><S><D><A><E><Q><Y><Y><C><V><A><E><N><G><Y><G><P><S><P><S><G><L><V><S><I><T><V><R><I><P><V><S><R><P><I><L><M><L><R><A><P><R><A><Q><A><A><V><E><D><V><L><E><L><H><C><E><A><L><R><G><S><P><P><I><L><Y><W><F><Y><H><E><D><I><T><L><G><S><R><S><A><P><S><G><G><G><A><S><F><N><L><S><L><T><E><E><H><S><G><N><Y><S><C><E><A><N><N><G><L><G><A><Q><R><S><E><A><V><T><L><N><F><T><V><P><T><G><A><R><S><N><H><L><T><S><G><V><I><E><G><L><L><S><T><L><G><P><A><T><V><A><L><L><F><C><Y><G><L><K><R><K><I><G><R><R><S><A><R><D><P><L><R><S><L><P><S><P><L><P><Q><E><F><T><Y><L><N><S><P><T><P><G><Q><L><Q><P><I><Y><E><N><V><N><V><V><S><G><D><E><V><Y><S><L><A><Y><Y><N><Q><P><E><Q><E><S><V><A><A><E><T><L><G><T><H><M><E><D><K><V><S><L><D><I><Y><S><R><L><R><K><A><N><I><T><D><V><D><Y><E><D><A><M>
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.<BOP>
Q96LA6
Q7L4E1
MIGA2_HUMAN
Protein FAM73B
Homo
<M><A><F><R><R><A><E><G><T><S><M><I><Q><A><L><A><M><T><V><A><E><I><P><V><F><L><Y><T><T><F><G><Q><S><A><F><S><Q><L><R><L><T><P><G><L><R><K><V><L><F><A><T><A><L><G><T><V><A><L><A><L><A><A><H><Q><L><K><R><R><R><R><R><K><K><Q><V><G><P><E><M><G><G><E><Q><L><G><T><V><P><L><P><I><L><L><A><R><K><V><P><S><V><K><K><G><Y><S><S><R><R><V><Q><S><P><S><S><K><S><N><D><T><L><S><G><I><S><S><I><E><P><S><K><H><S><G><S><S><H><S><V><A><S><M><M><A><V><N><S><S><S><P><T><A><A><C><S><G><L><W><D><A><R><G><M><E><E><S><L><T><T><S><D><G><N><A><E><S><L><Y><M><Q><G><M><E><L><F><E><E><A><L><Q><K><W><E><Q><A><L><S><V><G><Q><R><G><D><S><G><S><T><P><M><P><R><D><G><L><R><N><P><E><T><A><S><E><P><L><S><E><P><E><S><Q><R><K><E><F><A><E><K><L><E><S><L><L><H><R><A><Y><H><L><Q><E><E><F><G><S><T><F><P><A><D><S><M><L><L><D><L><E><R><T><L><M><L><P><L><T><E><G><S><L><R><L><R><A><D><D><E><D><S><L><T><S><E><D><S><F><F><S><A><T><E><L><F><E><S><L><Q><T><G><D><Y><P><I><P><L><S><R><P><A><A><A><Y><E><E><A><L><Q><L><V><K><E><G><R><V><P><C><R><T><L><R><T><E><L><L><G><C><Y><S><D><Q><D><F><L><A><K><L><H><C><V><R><Q><A><F><E><G><L><L><E><D><K><S><N><Q><L><F><F><G><K><V><G><R><Q><M><V><T><G><L><M><T><K><A><E><K><S><P><K><G><F><L><E><S><Y><E><E><M><L><S><Y><A><L><R><P><E><T><W><A><T><T><R><L><E><L><E><G><R><G><V><V><C><M><S><F><F><D><I><V><L><D><F><I><L><M><D><A><F><E><D><L><E><N><P><P><A><S><V><L><A><V><L><R><N><R><W><L><S><D><S><F><K><E><T><A><L><A><T><A><C><W><S><V><L><K><A><K><R><R><L><L><M><V><P><D><G><F><I><S><H><F><Y><S><V><S><E><H><V><S><P><V><L><A><F><G><F><L><G><P><K><P><Q><L><A><E><V><C><A><F><F><K><H><Q><I><V><Q><Y><L><R><D><M><F><D><L><D><N><V><R><Y><T><S><L><P><A><L><A><D><D><I><L><Q><L><S><R><R><R><S><E><I><L><L><G><Y><L><G><V><P><A><A><S><S><A><G><V><N><G><A><L><P><R><E><N><G><P><L><G><E><L><Q>
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.<BOP>
Q7L4E1
A0A0C4DH28
TRGV4_HUMAN
T cell receptor gamma variable 4
Homo
<M><Q><W><A><L><A><V><L><L><A><F><L><S><P><A><S><Q><K><S><S><N><L><E><G><R><T><K><S><V><I><R><Q><T><G><S><S><A><E><I><T><C><D><L><A><E><G><S><T><G><Y><I><H><W><Y><L><H><Q><E><G><K><A><P><Q><R><L><L><Y><Y><D><S><Y><T><S><S><V><V><L><E><S><G><I><S><P><G><K><Y><D><T><Y><G><S><T><R><K><N><L><R><M><I><L><R><N><L><I><E><N><D><S><G><V><Y><Y><C><A><T><W><D><G>
V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential
A0A0C4DH28
Q6ZUV0
BACHL_HUMAN
Acyl-CoA thioesterase 7-like
Homo
<M><I><K><E><A><G><A><I><I><S><T><R><H><C><N><P><Q><N><G><D><R><C><V><A><A><L><A><R><V><E><C><T><H><F><L><W><P><M><C><I><G><E><V><A><H><V><S><A><E><I><T><Y><T><S><K><H><S><V><E><V><Q><V><N><M><M><S><E><N><I><L><T><G><A><K><K><L><T><N><K><A><T><L><W><Y><A><P><L><S><L><T><N><V><D><K><V><L><E><E><P><P><V><V><Y><F><R><Q><E><Q><E><E><E><G><Q><K><R><Y><K><T><Q><K><L><E><R><M><E><T><N><W><R><N><G><D><I><V><Q><P><V><L><N><P><E><P><N><T><V><S><Y><S><Q><S><S><L><I><H><L><V><G><P><S><D><C><T><L><H><S><F><V><H><E><G><V><T><M><K><V><M><D><E><V><A><G><I><L><A><A><R><H><C><K><T><N><L><V><T><A><S><M><E><A><I><N><F><D><N><K><I><R><K><G><C><I><K><T><I><S><G><R><M><T><F><T><S><N><K><S><V><E><I><E><V><L><V><D><A><D><C><V><V><D><S><S><Q><K><R><Y><R><A><A><S><V><F><T>
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.<BOP>
Q6ZUV0
Q8IZI9
IFNL3_HUMAN
Interleukin-28C
Homo
<M><T><G><D><C><M><P><V><L><V><L><M><A><A><V><L><T><V><T><G><A><V><P><V><A><R><L><R><G><A><L><P><D><A><R><G><C><H><I><A><Q><F><K><S><L><S><P><Q><E><L><Q><A><F><K><R><A><K><D><A><L><E><E><S><L><L><L><K><D><C><K><C><R><S><R><L><F><P><R><T><W><D><L><R><Q><L><Q><V><R><E><R><P><V><A><L><E><A><E><L><A><L><T><L><K><V><L><E><A><T><A><D><T><D><P><A><L><G><D><V><L><D><Q><P><L><H><T><L><H><H><I><L><S><Q><L><R><A><C><I><Q><P><Q><P><T><A><G><P><R><T><R><G><R><L><H><H><W><L><H><R><L><Q><E><A><P><K><K><E><S><P><G><C><L><E><A><S><V><T><F><N><L><F><R><L><L><T><R><D><L><N><C><V><A><S><G><D><L><C><V>
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.<BOP>
Q8IZI9
Q5EBM4
ZN542_HUMAN
Zinc finger protein 542 pseudogene
Homo
<M><L><E><N><Y><Q><N><L><V><W><L><G><L><S><I><S><K><S><V><I><S><L><L><E><K><R><K><L><P><W><I><M><A><K><E><E><I><R><G><P><L><P><G><Y><F><K><V><S><E><M><T><I><S><Q><E><P><K><A><K><T><R><T><L><F><G><K><D><V><P><G><A><E><I><K><E><L><S><A><K><R><A><I><N><E><V><L><S><Q><F><D><T><V><I><K><C><T><R><N><V><C><K><E><C><G><N><L><Y><C><H><N><M><Q><L><T><L><H><K><R><N><H><T><Q><K><K><C><N><Q><C><L><D><C><G><K><Y><F><T><R><Q><S><T><L><I><Q><H><Q><R><I><H><T><G><E><R><P><Y><K><C><N><E><C><I><K><T><F><N><Q><R><A><H><L><T>
May be involved in transcriptional regulation.<BOP>
Q5EBM4
P55273
CDN2D_HUMAN
p19-INK4d
Homo
<M><L><L><E><E><V><R><A><G><D><R><L><S><G><A><A><A><R><G><D><V><Q><E><V><R><R><L><L><H><R><E><L><V><H><P><D><A><L><N><R><F><G><K><T><A><L><Q><V><M><M><F><G><S><T><A><I><A><L><E><L><L><K><Q><G><A><S><P><N><V><Q><D><T><S><G><T><S><P><V><H><D><A><A><R><T><G><F><L><D><T><L><K><V><L><V><E><H><G><A><D><V><N><V><P><D><G><T><G><A><L><P><I><H><L><A><V><Q><E><G><H><T><A><V><V><S><F><L><A><A><E><S><D><L><H><R><R><D><A><R><G><L><T><P><L><E><L><A><L><Q><R><G><A><Q><D><L><V><D><I><L><Q><G><H><M><V><A><P><L>
Interacts strongly with CDK4 and CDK6 and inhibits them.<BOP>
P55273
Q13427
PPIG_HUMAN
Rotamase G
Homo
<M><G><I><K><V><Q><R><P><R><C><F><F><D><I><A><I><N><N><Q><P><A><G><R><V><V><F><E><L><F><S><D><V><C><P><K><T><C><E><N><F><R><C><L><C><T><G><E><K><G><T><G><K><S><T><Q><K><P><L><H><Y><K><S><C><L><F><H><R><V><V><K><D><F><M><V><Q><G><G><D><F><S><E><G><N><G><R><G><G><E><S><I><Y><G><G><F><F><E><D><E><S><F><A><V><K><H><N><K><E><F><L><L><S><M><A><N><R><G><K><D><T><N><G><S><Q><F><F><I><T><T><K><P><T><P><H><L><D><G><H><H><V><V><F><G><Q><V><I><S><G><Q><E><V><V><R><E><I><E><N><Q><K><T><D><A><A><S><K><P><F><A><E><V><R><I><L><S><C><G><E><L><I><P><K><S><K><V><K><K><E><E><K><K><R><H><K><S><S><S><S><S><S><S><S><S><S><D><S><D><S><S><S><D><S><Q><S><S><S><D><S><S><D><S><E><S><A><T><E><E><K><S><K><K><R><K><K><K><H><R><K><N><S><R><K><H><K><K><E><K><K><K><R><K><K><S><K><K><S><A><S><S><E><S><E><A><E><N><L><E><A><Q><P><Q><S><T><V><R><P><E><E><I><P><P><I><P><E><N><R><F><L><M><R><K><S><P><P><K><A><D><E><K><E><R><K><N><R><E><R><E><R><E><R><E><C><N><P><P><N><S><Q><P><A><S><Y><Q><R><R><L><L><V><T><R><S><G><R><K><I><K><G><R><G><P><R><R><Y><R><T><P><S><R><S><R><S><R><D><R><F><R><R><S><E><T><P><P><H><W><R><Q><E><M><Q><R><A><Q><R><M><R><V><S><S><G><E><R><W><I><K><G><D><K><S><E><L><N><E><I><K><E><N><Q><R><S><P><V><R><V><K><E><R><K><I><T><D><H><R><N><V><S><E><S><P><N><R><K><N><E><K><E><K><K><V><K><D><H><K><S><N><S><K><E><R><D><I><R><R><N><S><E><K><D><D><K><Y><K><N><K><V><K><K><R><A><K><S><K><S><R><S><K><S><K><E><K><S><K><S><K><E><R><D><S><K><H><N><R><N><E><E><K><R><M><R><S><R><S><K><G><R><D><H><E><N><V><K><E><K><E><K><Q><S><D><S><K><G><K><D><Q><E><R><S><R><S><K><E><K><S><K><Q><L><E><S><K><S><N><E><H><D><H><S><K><S><K><E><K><D><R><R><A><Q><S><R><S><R><E><C><D><I><T><K><G><K><H><S><Y><N><S><R><T><R><E><R><S><R><S><R><D><R><S><R><R><V><R><S><R><T><H><D><R><D><R><S><R><S><K><E><Y><H><R><Y><R><E><Q><E><Y><R><R><R><G><R><S><R><S><R><E><R><R><T><P><P><G><R><S><R><S><K><D><R><R><R><R><R><R><D><S><R><S><S><E><R><E><E><S><Q><S><R><N><K><D><K><Y><R><N><Q><E><S><K><S><S><H><R><K><E><N><S><E><S><E><K><R><M><Y><S><K><S><R><D><H><N><S><S><N><N><S><R><E><K><K><A><D><R><D><Q><S><P><F><S><K><I><K><Q><S><S><Q><D><N><E><L><K><S><S><M><L><K><N><K><E><D><E><K><I><R><S><S><V><E><K><E><N><Q><K><S><K><G><Q><E><N><D><H><V><H><E><K><N><K><K><F><D><H><E><S><S><P><G><T><D><E><D><K><S><G>
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding . May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.<BOP>
Q13427
Q15697
ZN174_HUMAN
Zinc finger and SCAN domain-containing protein 8
Homo
<M><A><A><K><M><E><I><T><L><S><S><N><T><E><A><S><S><K><Q><E><R><H><I><I><A><K><L><E><E><K><R><G><P><P><L><Q><K><N><C><P><D><P><E><L><C><R><Q><S><F><R><R><F><C><Y><Q><E><V><S><G><P><Q><E><A><L><S><Q><L><R><Q><L><C><R><Q><W><L><Q><P><E><L><H><T><K><E><Q><I><L><E><L><L><V><M><E><Q><F><L><T><I><L><P><P><E><I><Q><A><R><V><R><H><R><C><P><M><S><S><K><E><I><V><T><L><V><E><D><F><H><R><A><S><K><K><P><K><Q><W><V><A><V><C><M><Q><G><Q><K><V><L><L><E><K><T><G><S><Q><L><G><E><Q><E><L><P><D><F><Q><P><Q><T><P><R><R><D><L><R><E><S><S><P><A><E><P><S><Q><A><G><A><Y><D><R><L><S><P><H><H><W><E><K><S><P><L><L><Q><E><P><T><P><K><L><A><G><T><E><A><P><R><M><R><S><D><N><K><E><N><P><Q><Q><E><G><A><K><G><A><K><P><C><A><V><S><A><G><R><S><K><G><N><G><L><Q><N><P><E><P><R><G><A><N><M><S><E><P><R><L><S><R><R><Q><V><S><S><P><N><A><Q><K><P><F><A><H><Y><Q><R><H><C><R><V><E><Y><I><S><S><P><L><K><S><H><P><L><R><E><L><K><K><S><K><G><G><K><R><S><L><S><N><R><L><Q><H><L><G><H><Q><P><T><R><S><A><K><K><P><Y><K><C><D><D><C><G><K><S><F><T><W><N><S><E><L><K><R><H><K><R><V><H><T><G><E><R><P><Y><T><C><G><E><C><G><N><C><F><G><R><Q><S><T><L><K><L><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><G><Q><C><G><K><S><F><R><Q><S><S><N><L><H><Q><H><H><R><L><H><H><G><D>
Transcriptional repressor.<BOP>
Q15697
Q9Y5U4
INSI2_HUMAN
Insulin-induced gene 2 protein
Homo
<M><A><E><G><E><T><E><S><P><G><P><K><K><C><G><P><Y><I><S><S><V><T><S><Q><S><V><N><L><M><I><R><G><V><V><L><F><F><I><G><V><F><L><A><L><V><L><N><L><L><Q><I><Q><R><N><V><T><L><F><P><P><D><V><I><A><S><I><F><S><S><A><W><W><V><P><P><C><C><G><T><A><S><A><V><I><G><L><L><Y><P><C><I><D><R><H><L><G><E><P><H><K><F><K><R><E><W><S><S><V><M><R><C><V><A><V><F><V><G><I><N><H><A><S><A><K><V><D><F><D><N><N><I><Q><L><S><L><T><L><A><A><L><S><I><G><L><W><W><T><F><D><R><S><R><S><G><F><G><L><G><V><G><I><A><F><L><A><T><V><V><T><Q><L><L><V><Y><N><G><V><Y><Q><Y><T><S><P><D><F><L><Y><V><R><S><W><L><P><C><I><F><F><A><G><G><I><T><M><G><N><I><G><R><Q><L><A><M><Y><E><C><K><V><I><A><E><K><S><H><Q><E>
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR . Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 . Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum . In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi . Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between
Q9Y5U4
O75367
H2AY_HUMAN
Medulloblastoma antigen MU-MB-50.205
Homo
<M><S><S><R><G><G><K><K><K><S><T><K><T><S><R><S><A><K><A><G><V><I><F><P><V><G><R><M><L><R><Y><I><K><K><G><H><P><K><Y><R><I><G><V><G><A><P><V><Y><M><A><A><V><L><E><Y><L><T><A><E><I><L><E><L><A><G><N><A><A><R><D><N><K><K><G><R><V><T><P><R><H><I><L><L><A><V><A><N><D><E><E><L><N><Q><L><L><K><G><V><T><I><A><S><G><G><V><L><P><N><I><H><P><E><L><L><A><K><K><R><G><S><K><G><K><L><E><A><I><I><T><P><P><P><A><K><K><A><K><S><P><S><Q><K><K><P><V><S><K><K><A><G><G><K><K><G><A><R><K><S><K><K><K><Q><G><E><V><S><K><A><A><S><A><D><S><T><T><E><G><T><P><A><D><G><F><T><V><L><S><T><K><S><L><F><L><G><Q><K><L><Q><V><V><Q><A><D><I><A><S><I><D><S><D><A><V><V><H><P><T><N><T><D><F><Y><I><G><G><E><V><G><N><T><L><E><K><K><G><G><K><E><F><V><E><A><V><L><E><L><R><K><K><N><G><P><L><E><V><A><G><A><A><V><S><A><G><H><G><L><P><A><K><F><V><I><H><C><N><S><P><V><W><G><A><D><K><C><E><E><L><L><E><K><T><V><K><N><C><L><A><L><A><D><D><K><K><L><K><S><I><A><F><P><S><I><G><S><G><R><N><G><F><P><K><Q><T><A><A><Q><L><I><L><K><A><I><S><S><Y><F><V><S><T><M><S><S><S><I><K><T><V><Y><F><V><L><F><D><S><E><S><I><G><I><Y><V><Q><E><M><A><K><L><D><A><N>
In contrast to isoform 1, does not bind poly-ADP-ribose . Represses SOD3 gene expression .<BOP>
O75367
P20061
TCO1_HUMAN
Transcobalamin I
Homo
<M><R><Q><S><H><Q><L><P><L><V><G><L><L><L><F><S><F><I><P><S><Q><L><C><E><I><C><E><V><S><E><E><N><Y><I><R><L><K><P><L><L><N><T><M><I><Q><S><N><Y><N><R><G><T><S><A><V><N><V><V><L><S><L><K><L><V><G><I><Q><I><Q><T><L><M><Q><K><M><I><Q><Q><I><K><Y><N><V><K><S><R><L><S><D><V><S><S><G><E><L><A><L><I><I><L><A><L><G><V><C><R><N><A><E><E><N><L><I><Y><D><Y><H><L><I><D><K><L><E><N><K><F><Q><A><E><I><E><N><M><E><A><H><N><G><T><P><L><T><N><Y><Y><Q><L><S><L><D><V><L><A><L><C><L><F><N><G><N><Y><S><T><A><E><V><V><N><H><F><T><P><E><N><K><N><Y><Y><F><G><S><Q><F><S><V><D><T><G><A><M><A><V><L><A><L><T><C><V><K><K><S><L><I><N><G><Q><I><K><A><D><E><G><S><L><K><N><I><S><I><Y><T><K><S><L><V><E><K><I><L><S><E><K><K><E><N><G><L><I><G><N><T><F><S><T><G><E><A><M><Q><A><L><F><V><S><S><D><Y><Y><N><E><N><D><W><N><C><Q><Q><T><L><N><T><V><L><T><E><I><S><Q><G><A><F><S><N><P><N><A><A><A><Q><V><L><P><A><L><M><G><K><T><F><L><D><I><N><K><D><S><S><C><V><S><A><S><G><N><F><N><I><S><A><D><E><P><I><T><V><T><P><P><D><S><Q><S><Y><I><S><V><N><Y><S><V><R><I><N><E><T><Y><F><T><N><V><T><V><L><N><G><S><V><F><L><S><V><M><E><K><A><Q><K><M><N><D><T><I><F><G><F><T><M><E><E><R><S><W><G><P><Y><I><T><C><I><Q><G><L><C><A><N><N><N><D><R><T><Y><W><E><L><L><S><G><G><E><P><L><S><Q><G><A><G><S><Y><V><V><R><N><G><E><N><L><E><V><R><W><S><K><Y>
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.<BOP>
P20061
P01772
HV333_HUMAN
Ig heavy chain V-III region KOL
Homo
<M><E><F><G><L><S><W><V><F><L><V><A><L><L><R><G><V><Q><C><Q><V><Q><L><V><E><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><G><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><I><W><Y><D><G><S><N><K><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01772
Q16384
SSX1_HUMAN
Synovial sarcoma, X breakpoint 1
Homo
<M><N><G><D><D><T><F><A><K><R><P><R><D><D><A><K><A><S><E><K><R><S><K><A><F><D><D><I><A><T><Y><F><S><K><K><E><W><K><K><M><K><Y><S><E><K><I><S><Y><V><Y><M><K><R><N><Y><K><A><M><T><K><L><G><F><K><V><T><L><P><P><F><M><C><N><K><Q><A><T><D><F><Q><G><N><D><F><D><N><D><H><N><R><R><I><Q><V><E><H><P><Q><M><T><F><G><R><L><H><R><I><I><P><K><I><M><P><K><K><P><A><E><D><E><N><D><S><K><G><V><S><E><A><S><G><P><Q><N><D><G><K><Q><L><H><P><P><G><K><A><N><I><S><E><K><I><N><K><R><S><G><P><K><R><G><K><H><A><W><T><H><R><L><R><E><R><K><Q><L><V><I><Y><E><E><I><S><D><P><E><E><D><D><E>
Could act as a modulator of transcription.<BOP>
Q16384
P52747
ZN143_HUMAN
Selenocysteine tRNA gene transcription-activating factor
Homo
<M><L><L><A><Q><I><N><R><D><S><Q><G><M><T><E><F><P><G><G><G><M><E><A><Q><H><V><T><L><C><L><T><E><A><V><T><V><A><D><G><D><N><L><E><N><M><E><G><V><S><L><Q><A><V><T><L><A><D><G><S><T><A><Y><I><Q><H><N><S><K><D><A><K><L><I><D><G><Q><V><I><Q><L><E><D><G><S><A><A><Y><V><Q><H><V><P><I><P><K><S><T><G><D><S><L><R><L><E><D><G><Q><A><V><Q><L><E><D><G><T><T><A><F><I><H><H><T><S><K><D><S><Y><D><Q><S><A><L><Q><A><V><Q><L><E><D><G><T><T><A><Y><I><H><H><A><V><Q><V><P><Q><S><D><T><I><L><A><I><Q><A><D><G><T><V><A><G><L><H><T><G><D><A><T><I><D><P><D><T><I><S><A><L><E><Q><Y><A><A><K><V><S><I><D><G><S><E><S><V><A><G><T><G><M><I><G><E><N><E><Q><E><K><K><M><Q><I><V><L><Q><G><H><A><T><R><V><T><A><K><S><Q><Q><S><G><E><K><A><F><R><C><E><Y><D><G><C><G><K><L><Y><T><T><A><H><H><L><K><V><H><E><R><S><H><T><G><D><R><P><Y><Q><C><E><H><A><G><C><G><K><A><F><A><T><G><Y><G><L><K><S><H><V><R><T><H><T><G><E><K><P><Y><R><C><S><E><D><N><C><T><K><S><F><K><T><S><G><D><L><Q><K><H><I><R><T><H><T><G><E><R><P><F><K><C><P><F><E><G><C><G><R><S><F><T><T><S><N><I><R><K><V><H><V><R><T><H><T><G><E><R><P><Y><Y><C><T><E><P><G><C><G><R><A><F><A><S><A><T><N><Y><K><N><H><V><R><I><H><T><G><E><K><P><Y><V><C><T><V><P><G><C><D><K><R><F><T><E><Y><S><S><L><Y><K><H><H><V><V><H><T><H><S><K><P><Y><N><C><N><H><C><G><K><T><Y><K><Q><I><S><T><L><A><M><H><K><R><T><A><H><N><D><T><E><P><I><E><E><E><Q><E><A><F><F><E><P><P><P><G><Q><G><E><D><V><L><K><G><S><Q><I><T><Y><V><T><G><V><E><G><D><D><V><V><S><T><Q><V><A><T><V><T><Q><S><G><L><S><Q><Q><V><T><L><I><S><Q><D><G><T><Q><H><V><N><I><S><Q><A><D><M><Q><A><I><G><N><T><I><T><M><V><T><Q><D><G><T><P><I><T><V><P><A><H><D><A><V><I><S><S><A><G><T><H><S><V><A><M><V><T><A><E><G><T><E><G><E><Q><V><A><I><V><A><Q><D><L><A><A><F><H><T><A><S><S><E><M><G><H><Q><Q><H><S><H><H><L><V><T><T><E><T><R><P><L><T><L><V><A><T><S><N><G><T><Q><I><A><V><Q><L><G><E><Q><P><S><L><E><E><A><I><R><I><A><S><R><I><Q><Q><G><E><T><P><G><L><D><D>
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.<BOP>
P52747
A0A075B6N3
TVBX1_HUMAN
T cell receptor beta variable 24-1
Homo
<M><A><S><L><L><F><F><C><G><A><F><Y><L><L><G><T><G><S><M><D><A><D><V><T><Q><T><P><R><N><R><I><T><K><T><G><K><R><I><M><L><E><C><S><Q><T><K><G><H><D><R><M><Y><W><Y><R><Q><D><P><G><L><G><L><Q><L><I><Y><Y><S><F><D><V><K><D><I><N><K><G><E><I><S><D><G><Y><S><V><S><R><Q><A><Q><A><K><F><S><L><S><L><E><S><A><I><P><N><Q><T><A><L><Y><F><C><A><T><S><D><L>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A075B6N3
Q8N9L1
ZIC4_HUMAN
Zinc finger protein of the cerebellum 4
Homo
<M><R><Y><K><T><S><L><V><M><R><K><R><L><R><L><Y><R><N><T><L><K><E><S><S><S><S><S><G><H><H><G><P><Q><L><T><A><A><S><S><P><S><V><F><P><G><L><H><E><E><P><P><Q><A><S><P><S><R><P><L><N><G><L><L><R><L><G><L><P><G><D><M><Y><A><R><P><E><P><F><P><P><G><P><A><A><R><S><D><A><L><A><A><A><A><A><L><H><G><Y><G><G><M><N><L><T><V><N><L><A><A><P><H><G><P><G><A><F><F><R><Y><M><R><Q><P><I><K><Q><E><L><I><C><K><W><L><A><A><D><G><T><A><T><P><S><L><C><S><K><T><F><S><T><M><H><E><L><V><T><H><V><T><V><E><H><V><G><G><P><E><Q><A><N><H><I><C><F><W><E><E><C><P><R><Q><G><K><P><F><K><A><K><Y><K><L><V><N><H><I><R><V><H><T><G><E><K><P><F><P><C><P><F><P><G><C><G><K><V><F><A><R><S><E><N><L><K><I><H><K><R><T><H><T><G><E><K><P><F><R><C><E><F><E><G><C><E><R><R><F><A><N><S><S><D><R><K><K><H><S><H><V><H><T><S><D><K><P><Y><T><C><K><V><R><G><C><D><K><C><Y><T><H><P><S><S><L><R><K><H><M><K><V><H><G><R><S><P><P><P><S><S><G><Y><D><S><A><T><P><S><A><L><V><S><P><S><S><D><C><G><H><K><S><Q><V><A><S><S><A><A><V><A><A><R><T><A><D><L><S><E>
Binds to DNA.<BOP>
Q8N9L1
O75563
SKAP2_HUMAN
Src-associated adapter protein with PH and SH3 domains
Homo
<M><P><N><P><S><S><T><S><S><P><Y><P><L><P><E><E><I><R><N><L><L><A><D><V><E><T><F><V><A><D><I><L><K><G><E><N><L><S><K><K><A><K><E><K><R><E><S><L><I><K><K><I><K><D><V><K><S><I><Y><L><Q><E><F><Q><D><K><G><D><A><E><D><G><E><E><Y><D><D><P><F><A><G><P><P><D><T><I><S><L><A><S><E><R><Y><D><K><D><D><E><A><P><S><D><G><A><Q><F><P><P><I><A><A><Q><D><L><P><F><V><L><K><A><G><Y><L><E><K><R><R><K><D><H><S><F><L><G><F><E><W><Q><K><R><W><C><A><L><S><K><T><V><F><Y><Y><Y><G><S><D><K><D><K><Q><Q><K><G><E><F><A><I><D><G><Y><S><V><R><M><N><N><T><L><R><K><D><G><K><K><D><C><C><F><E><I><S><A><P><D><K><R><I><Y><Q><F><T><A><A><S><P><K><D><A><E><E><W><V><Q><Q><L><K><F><V><L><Q><D><M><E><S><D><I><I><P><E><D><Y><D><E><R><G><E><L><Y><D><D><V><D><H><P><L><P><I><S><N><P><L><T><S><S><Q><P><I><D><D><E><I><Y><E><E><L><P><E><E><E><E><D><S><A><P><V><K><V><E><E><Q><R><K><M><S><Q><D><S><V><H><H><T><S><G><D><K><S><T><D><Y><A><N><F><Y><Q><G><L><W><D><C><T><G><A><F><S><D><E><L><S><F><K><R><G><D><V><I><Y><I><L><S><K><E><Y><N><R><Y><G><W><W><V><G><E><M><K><G><A><I><G><L><V><P><K><A><Y><I><M><E><M><Y><D><I>
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.<BOP>
O75563
Q9H3V2
MS4A5_HUMAN
Testis-expressed transmembrane protein 4
Homo
<M><D><S><S><T><A><H><S><P><V><F><L><V><F><P><P><E><I><T><A><S><E><Y><E><S><T><E><L><S><A><T><T><F><S><T><Q><S><P><L><Q><K><L><F><A><R><K><M><K><I><L><G><T><I><Q><I><L><F><G><I><M><T><F><S><F><G><V><I><F><L><F><T><L><L><K><P><Y><P><R><F><P><F><I><F><L><S><G><Y><P><F><W><G><S><V><L><F><I><N><S><G><A><F><L><I><A><V><K><R><K><T><T><E><T><L><I><I><L><S><R><I><M><N><F><L><S><A><L><G><A><I><A><G><I><I><L><L><T><F><G><F><I><L><D><Q><N><Y><I><C><G><Y><S><H><Q><N><S><Q><C><K><A><V><T><V><L><F><L><G><I><L><I><T><L><M><T><F><S><I><I><E><L><F><I><S><L><P><F><S><I><L><G><C><H><S><E><D><C><D><C><E><Q><C><C>
May be involved in signal transduction as a component of a multimeric receptor complex.<BOP>
Q9H3V2
Q96PD5
PGRP2_HUMAN
Peptidoglycan recognition protein long
Homo
<M><A><Q><G><V><L><W><I><L><L><G><L><L><L><W><S><D><P><G><T><A><S><L><P><L><L><M><D><S><V><I><Q><A><L><A><E><L><E><Q><K><V><P><A><A><K><T><R><H><T><A><S><A><W><L><M><S><A><P><N><S><G><P><H><N><R><L><Y><H><F><L><L><G><A><W><S><L><N><A><T><E><L><D><P><C><P><L><S><P><E><L><L><G><L><T><K><E><V><A><R><H><D><V><R><E><G><K><E><Y><G><V><V><L><A><P><D><G><S><T><V><A><V><E><P><L><L><A><G><L><E><A><G><L><Q><G><R><R><V><I><N><L><P><L><D><S><M><A><A><P><W><E><T><G><D><T><F><P><D><V><V><A><I><A><P><D><V><R><A><T><S><S><P><G><L><R><D><G><S><P><D><V><T><T><A><D><I><G><A><N><T><P><D><A><T><K><G><C><P><D><V><Q><A><S><L><P><D><A><K><A><K><S><P><P><T><M><V><D><S><L><L><A><V><T><L><A><G><N><L><G><L><T><F><L><R><G><S><Q><T><Q><S><H><P><D><L><G><T><E><G><C><W><D><Q><L><S><A><P><R><T><F><T><L><L><D><P><K><A><S><L><L><T><M><A><F><L><N><G><A><L><D><G><V><I><L><G><D><Y><L><S><R><T><P><E><P><R><P><S><L><S><H><L><L><S><Q><Y><Y><G><A><G><V><A><R><D><P><G><F><R><S><N><F><R><R><Q><N><G><A><A><L><T><S><A><S><I><L><A><Q><Q><V><W><G><T><L><V><L><L><Q><R><L><E><P><V><H><L><Q><L><Q><C><M><S><Q><E><Q><L><A><Q><V><A><A><N><A><T><K><E><F><T><E><A><F><L><G><C><P><A><I><H><P><R><C><R><W><G><A><A><P><Y><R><G><R><P><K><L><L><Q><L><P><L><G><F><L><Y><V><H><H><T><Y><V><P><A><P><P><C><T><D><F><T><R><C><A><A><N><M><R><S><M><Q><R><Y><H><Q><D><T><Q><G><W><G><D><I><G><Y><S><F><V><V><G><S><D><G><Y><V><Y><E><G><R><G><W><H><W><V><G><A><H><T><L><G><H><N><S><R><G><F><G><V><A><I><V><G><N><Y><T><A><A><L><P><T><E><A><A><L><R><T><V><R><D><T><L><P><S><C><A><V><R><A><G><L><L><R><P><D><Y><A><L><L><G><H><R><Q><L><V><R><T><D><C><P><G><D><A><L><F><D><L><L><R><T><W><P><H><F><T><A><T><V><K><P><R><P><A><R><S><V><S><K><R><S><R><R><E><P><P><P><R><T><L><P><A><T><D><L><Q>
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.<BOP>
Q96PD5
Q8N141
ZFP82_HUMAN
Zinc finger protein 545
Homo
<M><A><L><R><S><V><M><F><S><D><V><S><I><D><F><S><P><E><E><W><E><Y><L><D><L><E><Q><K><D><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><S><L><G><C><F><I><S><K><P><D><V><I><S><S><L><E><Q><G><K><E><P><W><K><V><V><R><K><G><R><R><Q><Y><P><D><L><E><T><K><Y><E><T><K><K><L><S><L><E><N><D><I><Y><E><I><N><L><S><Q><W><K><I><M><E><R><I><E><N><H><G><L><K><G><L><I><L><K><N><D><W><E><S><T><G><K><I><E><G><Q><E><R><P><Q><E><G><Y><F><S><S><V><K><M><P><S><E><K><V><S><S><Y><Q><K><R><T><S><V><T><P><H><Q><R><L><H><F><V><D><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><R><Q><Q><L><T><F><H><H><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><M><A><F><R><Q><T><A><H><L><T><R><H><Q><R><L><H><S><G><E><K><L><Y><E><C><K><E><C><G><E><A><F><I><C><G><A><D><L><R><V><H><Q><K><M><H><I><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><R><G><Q><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><V><C><K><E><C><G><K><A><F><R><Q><Y><A><H><L><T><R><H><Q><K><L><N><S><A><D><R><L><Y><E><C><K><E><C><G><K><A><F><L><C><G><S><G><L><R><V><H><H><K><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><R><Q><Q><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><S><R><G><Y><H><L><I><L><H><H><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><W><K><A><F><S><R><Y><S><Q><L><I><S><H><Q><S><I><H><I><G><V><K><P><Y><D><C><K><E><C><G><K><A><F><R><L><L><S><Q><L><T><Q><H><Q><S><I><H><I><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><R><L><R><Q><K><L><T><L><H><Q><S><I><H><T><G><E><K><P><F><E><C><K><E><C><R><K><A><F><R><L><N><S><S><L><I><Q><H><L><R><I><H><S><G><E><K><P><Y><E><C><K><E><C><K><K><A><F><R><Q><H><S><H><L><T><H><H><L><K><I><H><N><V><K><I>
May be involved in transcriptional regulation.<BOP>
Q8N141
Q5JXM2
MET24_HUMAN
Probable methyltransferase-like protein 24
Homo
<M><A><R><E><R><P><P><G><R><G><C><G><V><L><R><R><C><L><L><G><A><V><L><L><F><G><L><R><L><C><A><E><L><R><R><A><G><P><G><S><P><T><R><S><A><P><P><G><P><A><W><R><P><P><G><P><H><L><P><P><A><P><G><Q><P><R><G><A><S><R><R><Q><V><T><Y><V><R><S><G><R><R><A><P><P><G><G><G><G><S><G><T><P><E><P><G><C><C><A><P><R><G><R><P><R><R><K><G><P><R><W><H><I><D><L><Q><P><W><A><G><S><A><Q><S><L><D><E><E><A><W><R><F><L><R><Y><I><S><T><T><Q><I><A><C><N><H><M><N><T><D><S><L><A><T><D><S><S><P><T><H><K><P><W><S><V><C><L><D><D><R><F><N><L><A><H><Q><I><R><N><K><Q><C><R><L><Y><S><L><G><L><G><S><D><D><T><H><F><E><V><S><M><A><N><N><G><C><E><V><H><R><F><D><P><S><V><K><S><A><H><I><L><E><S><Q><H><L><W><Y><H><R><L><S><I><D><W><R><D><P><H><P><A><V><A><A><Q><K><P><H><S><N><T><R><K><L><G><S><I><L><N><E><F><G><H><H><K><I><D><V><L><K><A><D><L><E><S><A><E><W><K><V><L><E><N><L><I><L><E><D><V><L><E><Q><I><G><Q><L><I><F><E><I><H><L><H><W><P><G><F><E><V><S><G><S><D><S><S><V><V><R><F><W><Y><S><L><L><K><E><L><E><Q><K><D><F><R><L><F><H><S><Y><K><D><L><S><K><P><Q><L><F><L><K><K><D><I><F><N><A><S><S><C><Y><T><L><S><W><V><N><T><R><W><K>
Probable methyltransferase.<BOP>
Q5JXM2
P17032
ZN37A_HUMAN
Zinc finger protein KOX21
Homo
<M><I><T><S><Q><G><S><V><S><F><R><D><V><T><V><G><F><T><Q><E><E><W><Q><H><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><S><H><L><V><S><V><G><Y><C><I><P><K><P><E><V><I><L><K><L><E><K><G><E><E><P><W><I><L><E><E><K><F><P><S><Q><S><H><L><E><L><I><N><T><S><R><N><Y><S><I><M><K><F><N><E><F><N><K><G><G><K><C><F><C><D><E><K><H><E><I><I><H><S><E><E><E><P><S><E><Y><N><K><N><G><N><S><F><W><L><N><E><D><L><I><W><H><Q><K><I><K><N><W><E><Q><S><F><E><Y><N><E><C><G><K><A><F><P><E><N><S><L><F><L><V><H><K><R><G><Y><T><G><Q><K><T><C><K><Y><T><E><H><G><K><T><C><D><M><S><F><F><I><T><H><Q><Q><T><H><P><R><E><N><H><Y><G><N><E><C><G><E><N><I><F><E><E><S><I><L><L><E><H><Q><S><V><Y><P><F><S><Q><K><L><N><L><T><P><I><Q><R><T><H><S><I><N><N><I><I><E><Y><N><E><C><G><T><F><F><S><E><K><L><V><L><H><L><Q><Q><R><T><H><T><G><E><K><P><Y><E><C><H><E><C><G><K><T><F><T><Q><K><S><A><H><T><R><H><Q><R><T><H><T><G><G><K><P><Y><E><C><H><E><C><G><K><T><F><Y><K><N><S><D><L><I><K><H><Q><R><I><H><T><G><E><R><P><Y><G><C><H><E><C><G><K><S><F><S><E><K><S><T><L><T><Q><H><Q><R><T><H><T><G><E><K><P><Y><E><C><H><E><C><G><K><T><F><S><F><K><S><V><L><T><V><H><Q><K><T><H><T><G><E><K><P><Y><E><C><Y><A><C><G><K><A><F><L><R><K><S><D><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><S><F><S><E><K><S><T><L><T><K><H><L><R><T><H><T><G><E><K><P><Y><E><C><I><Q><C><G><K><F><F><C><Y><Y><S><G><F><T><E><H><L><R><R><H><T><G><E><K><P><F><G><C><N><E><C><G><K><T><F><R><Q><K><S><A><L><I><V><H><Q><R><T><H><I><R><Q><K><P><Y><G><C><N><Q><C><G><K><S><F><C><V><K><S><K><L><I><A><H><H><R><T><H><T><G><E><K><P><Y><E><C><N><V><C><G><K><S><F><Y><V><K><S><K><L><T><V><H><Q><R><I><H><L><G><R><N><P><I><N><V><V><N><E><G><N><Y><S><G>
May be involved in transcriptional regulation.<BOP>
P17032
B2RBV5
MRUPP_HUMAN
Unnamed protein product
Homo
<M><R><P><V><D><A><D><E><A><R><E><P><R><E><E><P><G><S><P><L><S><P><A><P><R><A><G><R><E><N><L><A><S><L><E><R><E><R><A><R><A><H><W><R><A><R><R><K><L><L><E><I><Q><S><L><L><D><A><I><K><S><E><V><E><A><E><E><R><G><A><R><A><P><A><P><R><P><R><A><E><A><E><E><R><V><A><R><L><C><A><E><A><E><R><K><A><A><E><A><A><R><M><G><R><R><I><V><E><L><H><Q><R><I><A><G><C><E><C><C>
May play a role in cell proliferation.<BOP>
B2RBV5
Q8NGE8
OR4D9_HUMAN
Olfactory receptor OR11-253
Homo
<M><D><Q><R><N><Y><T><R><V><K><E><F><T><F><L><G><I><T><Q><S><R><E><L><S><Q><V><L><F><T><F><L><F><L><V><Y><M><T><T><L><M><G><N><F><L><I><M><V><T><V><T><C><E><S><H><L><H><T><P><M><Y><F><L><L><R><N><L><S><I><L><D><I><C><F><S><S><I><T><A><P><K><V><L><I><D><L><L><S><E><T><K><T><I><S><F><S><G><C><V><T><Q><M><F><F><F><H><L><L><G><G><A><D><V><F><S><L><S><V><M><A><F><D><R><Y><I><A><I><S><K><P><L><H><Y><M><T><I><M><S><R><G><R><C><T><G><L><I><V><A><S><W><V><G><G><F><V><H><S><I><A><Q><I><S><L><L><L><P><L><P><F><C><G><P><N><V><L><D><T><F><Y><C><D><V><P><Q><V><L><K><L><A><C><T><D><T><F><T><L><E><L><L><M><I><S><N><N><G><L><V><S><W><F><V><F><F><F><L><L><I><S><Y><T><V><I><L><M><M><L><R><S><H><T><G><E><G><R><R><K><A><I><S><T><C><T><S><H><I><T><V><V><T><L><H><F><V><P><C><I><Y><V><Y><A><R><P><F><T><A><L><P><T><D><T><A><I><S><V><T><F><T><V><I><S><P><L><L><N><P><I><I><Y><T><L><R><N><Q><E><M><K><L><A><M><R><K><L><K><R><R><L><G><Q><S><E><R><I><L><I><Q>
Odorant receptor.<BOP>
Q8NGE8
Q9NQ31
AKIP1_HUMAN
Proline-rich protein BCA3
Homo
<M><D><N><C><L><A><A><A><A><L><N><G><V><D><R><R><S><L><Q><R><S><A><R><L><A><L><E><V><L><E><R><A><K><R><R><A><V><D><W><H><A><L><E><R><P><K><G><C><M><G><V><L><A><R><E><A><P><H><L><E><K><Q><P><A><A><G><P><Q><R><V><L><P><G><E><R><E><E><R><P><P><T><L><S><A><S><F><R><T><M><A><E><F><M><D><Y><T><S><S><Q><C><G><K><Y><Y><S><S><V><P><E><E><G><G><A><T><H><V><Y><R><Y><H><R><G><E><S><K><L><H><M><C><L><D><I><G><N><G><Q><R><K><D><R><K><K><T><S><L><G><P><G><G><S><Y><Q><I><S><E><H><A><P><E><A><S><Q><P><A><E><N><I><S><K><D><L><Y><I><E><V><Y><P><G><T><Y><S><V><T><V><G><S><N><D><L><T><K><K><T><H><V><V><A><V><D><S><G><Q><S><V><D><L><V><F><P><V>
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.<BOP>
Q9NQ31
P0C5Z0
H2AB2_HUMAN
H2A Barr body-deficient
Homo
<M><P><R><R><R><R><R><R><G><S><S><G><A><G><G><R><G><R><T><C><S><R><T><V><R><A><E><L><S><F><S><V><S><Q><V><E><R><S><L><R><E><G><H><Y><A><Q><R><L><S><R><T><A><P><V><Y><L><A><A><V><I><E><Y><L><T><A><K><V><L><E><L><A><G><N><E><A><Q><N><S><G><E><R><N><I><T><P><L><L><L><D><M><V><V><H><N><D><R><L><L><S><T><L><F><N><T><T><T><I><S><Q><V><A><P><G><E><D>
Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.<BOP>
P0C5Z0
Q53ET0
CRTC2_HUMAN
Transducer of regulated cAMP response element-binding protein 2
Homo
<M><A><T><S><G><A><N><G><P><G><S><A><T><A><S><A><S><N><P><R><K><F><S><E><K><I><A><L><Q><K><Q><R><Q><A><E><E><T><A><A><F><E><E><V><M><M><D><I><G><S><T><R><L><Q><A><Q><K><L><R><L><A><Y><T><R><S><S><H><Y><G><G><S><L><P><N><V><N><Q><I><G><S><G><L><A><E><F><Q><S><P><L><H><S><P><L><D><S><S><R><S><T><R><H><H><G><L><V><E><R><V><Q><R><D><P><R><R><M><V><S><P><L><R><R><Y><T><R><H><I><D><S><S><P><Y><S><P><A><Y><L><S><P><P><P><E><S><S><W><R><R><T><M><A><W><G><N><F><P><A><E><K><G><Q><L><F><R><L><P><S><A><L><N><R><T><S><S><D><S><A><L><H><T><S><V><M><N><P><S><P><Q><D><T><Y><P><G><P><T><P><P><S><I><L><P><S><R><R><G><G><I><L><D><G><E><M><D><P><K><V><P><A><I><E><E><N><L><L><D><D><K><H><L><L><K><P><W><D><A><K><K><L><S><S><S><S><S><R><P><R><S><C><E><V><P><G><I><N><I><F><P><S><P><D><Q><P><A><N><V><P><V><L><P><P><A><M><N><T><G><G><S><L><P><D><L><T><N><L><H><F><P><P><P><L><P><T><P><L><D><P><E><E><T><A><Y><P><S><L><S><G><G><N><S><T><S><N><L><T><H><T><M><T><H><L><G><I><S><R><G><M><G><L><G><P><G><Y><D><A><P><G><L><H><S><P><L><S><H><P><S><L><Q><S><S><L><S><N><P><N><L><Q><A><S><L><S><S><P><Q><P><Q><L><Q><G><S><H><S><H><P><S><L><P><A><S><S><L><A><R><H><V><L><P><T><T><S><L><G><H><P><S><L><S><A><P><A><L><S><S><S><S><S><S><S><S><T><S><S><P><V><L><G><A><P><S><Y><P><A><S><T><P><G><A><S><P><H><H><R><R><V><P><L><S><P><L><S><L><L><A><G><P><A><D><A><R><R><S><Q><Q><Q><L><P><K><Q><F><S><P><T><M><S><P><T><L><S><S><I><T><Q><G><V><P><L><D><T><S><K><L><S><T><D><Q><R><L><P><P><Y><P><Y><S><S><P><S><L><V><L><P><T><Q><P><H><T><P><K><S><L><Q><Q><P><G><L><P><S><Q><S><C><S><V><Q><S><S><G><G><Q><P><P><G><R><Q><S><H><Y><G><T><P><Y><P><P><G><P><S><G><H><G><Q><Q><S><Y><H><R><P><M><S><D><F><N><L><G><N><L><E><Q><F><S><M><E><S><P><S><A><S><L><V><L><D><P><P><G><F><S><E><G><P><G><F><L><G><G><E><G><P><M><G><G><P><Q><D><P><H><T><F><N><H><Q><N><L><T><H><C><S><R><H><G><S><G><P><N><I><I><L><T><G><D><S><S><P><G><F><S><K><E><I><A><A><A><L><A><G><V><P><G><F><E><V><S><A><A><G><L><E><L><G><L><G><L><E><D><E><L><R><M><E><P><L><G><L><E><G><L><N><M><L><S><D><P><C><A><L><L><P><D><P><A><V><E><E><S><F><R><S><D><R><L><Q>
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).<BOP>
Q53ET0
Q8TBA6
GOGA5_HUMAN
RET-fused gene 5 protein
Homo
<M><S><W><F><V><D><L><A><G><K><A><E><D><L><L><N><R><V><D><Q><G><A><A><T><A><L><S><R><K><D><N><A><S><N><I><Y><S><K><N><T><D><Y><T><E><L><H><Q><Q><N><T><D><L><I><Y><Q><T><G><P><K><S><T><Y><I><S><S><A><A><D><N><I><R><N><Q><K><A><T><I><L><A><G><T><A><N><V><K><V><G><S><R><T><P><V><E><A><S><H><P><V><E><N><A><S><V><P><R><P><S><S><H><F><V><R><R><K><K><S><E><P><D><D><E><L><L><F><D><F><L><N><S><S><Q><K><E><P><T><G><R><V><E><I><R><K><E><K><G><K><T><P><V><F><Q><S><S><Q><T><S><S><V><S><S><V><N><P><S><V><T><T><I><K><T><I><E><E><N><S><F><G><S><Q><T><H><E><A><A><S><N><S><D><S><S><H><E><G><Q><E><E><S><S><K><E><N><V><S><S><N><A><A><C><P><D><H><T><P><T><P><N><D><D><G><K><S><H><E><L><S><N><L><R><L><E><N><Q><L><L><R><N><E><V><Q><S><L><N><Q><E><M><A><S><L><L><Q><R><S><K><E><T><Q><E><E><L><N><K><A><R><A><R><V><E><K><W><N><A><D><H><S><K><S><D><R><M><T><R><G><L><R><A><Q><V><D><D><L><T><E><A><V><A><A><K><D><S><Q><L><A><V><L><K><V><R><L><Q><E><A><D><Q><L><L><S><T><R><T><E><A><L><E><A><L><Q><S><E><K><S><R><I><M><Q><D><Q><S><E><G><N><S><L><Q><N><Q><A><L><Q><T><F><Q><E><R><L><H><E><A><D><A><T><L><K><R><E><Q><E><S><Y><K><Q><M><Q><S><E><F><A><A><R><L><N><K><V><E><M><E><R><Q><N><L><A><E><A><I><T><L><A><E><R><K><Y><S><D><E><K><K><R><V><D><E><L><Q><Q><Q><V><K><L><Y><K><L><N><L><E><S><S><K><Q><E><L><I><D><Y><K><Q><K><A><T><R><I><L><Q><S><K><E><K><L><I><N><S><L><K><E><G><S><G><F><E><G><L><D><S><S><T><A><S><S><M><E><L><E><E><L><R><H><E><K><E><M><Q><R><E><E><I><Q><K><L><M><G><Q><I><H><Q><L><R><S><E><L><Q><D><M><E><A><Q><Q><V><N><E><A><E><S><A><R><E><Q><L><Q><D><L><H><D><Q><I><A><G><Q><K><A><S><K><Q><E><L><E><T><E><L><E><R><L><K><Q><E><F><H><Y><I><E><E><D><L><Y><R><T><K><N><T><L><Q><S><R><I><K><D><R><D><E><E><I><Q><K><L><R><N><Q><L><T><N><K><T><L><S><N><S><S><Q><S><E><L><E><N><R><L><H><Q><L><T><E><T><L><I><Q><K><Q><T><M><L><E><S><L><S><T><E><K><N><S><L><V><F><Q><L><E><R><L><E><Q><Q><M><N><S><A><S><G><S><S><S><N><G><S><S><I><N><M><S><G><I><D><N><G><E><G><T><R><L><R><N><V><P><V><L><F><N><D><T><E><T><N><L><A><G><M><Y><G><K><V><R><K><A><A><S><S><I><D><Q><F><S><I><R><L><G><I><F><L><R><R><Y><P><I><A><R><V><F><V><I><I><Y><M><A><L><L><H><L><W><V><M><I><V><L><L><T><Y><T><P><E><M><H><H><D><Q><P><Y><G><K>
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.<BOP>
Q8TBA6
A2IDD5
CCD78_HUMAN
hsCCDC78
Homo
<M><E><H><A><A><T><T><G><P><R><P><G><P><P><S><R><R><V><E><N><V><V><L><R><A><K><D><W><L><P><G><A><P><G><G><T><A><V><W><A><T><S><L><E><A><E><V><P><P><D><L><A><L><N><K><E><Q><Q><L><Q><I><S><K><E><L><V><D><I><Q><I><T><T><H><H><L><H><E><Q><H><E><A><E><I><F><Q><L><K><S><E><I><L><R><L><E><S><R><V><L><E><L><E><L><R><G><D><G><T><S><Q><G><C><A><V><P><V><E><S><D><P><R><H><P><R><A><A><A><Q><E><L><R><H><K><A><Q><V><P><G><H><S><D><D><H><R><F><Q><V><Q><P><K><N><T><M><N><P><E><N><E><Q><H><R><L><G><S><G><L><Q><G><E><V><K><W><A><L><E><H><Q><E><A><R><Q><Q><A><L><V><T><R><V><A><T><L><G><R><Q><L><Q><G><A><R><E><E><A><R><A><A><G><Q><R><L><A><T><Q><A><V><V><L><C><S><C><Q><G><Q><L><R><Q><A><E><A><E><N><A><R><L><Q><L><Q><L><K><K><L><K><D><E><Y><V><L><R><L><Q><H><C><A><W><Q><A><V><E><H><A><D><G><A><G><Q><A><P><A><T><T><A><L><R><T><F><L><E><A><T><L><E><D><I><R><A><A><H><R><S><R><E><Q><Q><L><A><R><A><A><R><S><Y><H><K><R><L><V><D><L><S><R><R><H><E><E><L><L><V><A><Y><R><A><P><G><N><P><Q><A><I><F><D><I><A><S><L><D><L><E><P><L><P><V><P><L><V><T><D><F><S><H><R><E><D><Q><H><G><G><P><G><A><L><L><S><S><P><K><K><R><P><G><G><A><S><Q><G><G><T><S><E><P><Q><G><L><D><A><A><S><W><A><Q><I><H><Q><K><L><R><D><F><S><R><S><T><Q><S><W><N><G><S><G><H><S><C><W><S><G><P><R><W><L><K><S><N><F><L><S><Y><R><S><T><W><T><S><T><W><A><G><T><S><T><K><S>
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome.<BOP>
A2IDD5
Q3LI66
KRA62_HUMAN
Keratin-associated protein 6-2
Homo
<M><C><G><S><Y><Y><G><N><Y><Y><G><D><H><G><Y><G><C><C><G><Y><E><G><L><G><Y><G><Y><G><S><L><R><C><G><Y><S><S><C><C><G><Y><G><H><G><Y><G><S><R><F><F><C><G><C><G><Y><G><C><G><S><G><Y><Y><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI66
Q6K0P9
IFIX_HUMAN
Interferon-inducible protein X
Homo
<M><A><N><N><Y><K><K><I><V><L><L><K><G><L><E><V><I><N><D><Y><H><F><R><I><V><K><S><L><L><S><N><D><L><K><L><N><P><K><M><K><E><E><Y><D><K><I><Q><I><A><D><L><M><E><E><K><F><P><G><D><A><G><L><G><K><L><I><E><F><F><K><E><I><P><T><L><G><D><L><A><E><T><L><K><R><E><K><L><K><V><A><N><K><I><E><S><I><P><V><K><G><I><I><P><S><K><K><T><K><Q><K><E><V><Y><P><A><T><P><A><C><T><P><S><N><R><L><T><A><K><G><A><E><E><T><L><G><P><Q><K><R><K><K><P><S><E><E><E><T><G><T><K><R><S><K><M><S><K><E><Q><T><R><P><S><C><S><A><G><A><S><T><S><T><A><M><G><R><S><P><P><P><Q><T><S><S><S><A><P><P><N><T><S><S><T><E><S><L><K><P><L><A><N><R><H><A><T><A><S><K><N><I><F><R><E><D><P><I><I><A><M><V><L><N><A><T><K><V><F><K><Y><E><S><S><E><N><E><Q><R><R><M><F><H><A><T><V><A><T><Q><T><Q><F><F><H><V><K><V><L><N><I><N><L><K><R><K><F><I><K><K><R><I><I><I><I><S><N><Y><S><K><R><N><S><L><L><E><V><N><E><A><S><S><V><S><E><A><G><P><D><Q><T><F><E><V><P><K><D><I><I><R><R><A><K><K><I><P><K><I><N><I><L><H><K><Q><T><S><G><Y><I><V><Y><G><L><F><M><L><H><T><K><I><V><N><R><K><T><T><I><Y><E><I><Q><D><K><T><G><S><M><A><V><V><G><K><G><E><C><H><N><I><P><C><E><K><G><D><K><L><R><L><F><C><F><R><L><R><K><R><E><N><M><S><K><L><M><S><E><M><H><S><F><I><Q><I><Q><K><N><T><N><Q><R><S><H><D><S><R><S><M><A><L><P><Q><E><Q><S><Q><H><P><K><P><S><E><A><S><T><T><L><P><E><S><H><L><K><T><P><Q><M><P><P><T><T><P><S><S><S><S><F><T><K><K><D><E><T><H><P><G><A><Q><S><S><P><A><N><F><R><I><T><S><P><T><V><A><P><P><L><S><S><D><T><S><T><N><R><H><P><A><V><P>
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.<BOP>
Q6K0P9
Q9NRB3
CHSTC_HUMAN
Sulfotransferase Hlo
Homo
<M><T><K><A><R><L><F><R><L><W><L><V><L><G><S><V><F><M><I><L><L><I><I><V><Y><W><D><S><A><G><A><A><H><F><Y><L><H><T><S><F><S><R><P><H><T><G><P><P><L><P><T><P><G><P><D><R><D><R><E><L><T><A><D><S><D><V><D><E><F><L><D><K><F><L><S><A><G><V><K><Q><S><D><L><P><R><K><E><T><E><Q><P><P><A><P><G><S><M><E><E><S><V><R><G><Y><D><W><S><P><R><D><A><R><R><S><P><D><Q><G><R><Q><Q><A><E><R><R><S><V><L><R><G><F><C><A><N><S><S><L><A><F><P><T><K><E><R><A><F><D><D><I><P><N><S><E><L><S><H><L><I><V><D><D><R><H><G><A><I><Y><C><Y><V><P><K><V><A><C><T><N><W><K><R><V><M><I><V><L><S><G><S><L><L><H><R><G><A><P><Y><R><D><P><L><R><I><P><R><E><H><V><H><N><A><S><A><H><L><T><F><N><K><F><W><R><R><Y><G><K><L><S><R><H><L><M><K><V><K><L><K><K><Y><T><K><F><L><F><V><R><D><P><F><V><R><L><I><S><A><F><R><S><K><F><E><L><E><N><E><E><F><Y><R><K><F><A><V><P><M><L><R><L><Y><A><N><H><T><S><L><P><A><S><A><R><E><A><F><R><A><G><L><K><V><S><F><A><N><F><I><Q><Y><L><L><D><P><H><T><E><K><L><A><P><F><N><E><H><W><R><Q><V><Y><R><L><C><H><P><C><Q><I><D><Y><D><F><V><G><K><L><E><T><L><D><E><D><A><A><Q><L><L><Q><L><L><Q><V><D><R><Q><L><R><F><P><P><S><Y><R><N><R><T><A><S><S><W><E><E><D><W><F><A><K><I><P><L><A><W><R><Q><Q><L><Y><K><L><Y><E><A><D><F><V><L><F><G><Y><P><K><P><E><N><L><L><R><D>
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.<BOP>
Q9NRB3
Q96AJ9
VTI1A_HUMAN
Vti1-rp2
Homo
<M><S><S><D><F><E><G><Y><E><Q><D><F><A><V><L><T><A><E><I><T><S><K><I><A><R><V><P><R><L><P><P><D><E><K><K><Q><M><V><A><N><V><E><K><Q><L><E><E><A><K><E><L><L><E><Q><M><D><L><E><V><R><E><I><P><P><Q><S><R><G><M><Y><S><N><R><M><R><S><Y><K><Q><E><M><G><K><L><E><T><D><F><K><R><S><R><I><A><Y><S><D><E><V><R><N><E><L><L><G><D><D><G><N><S><S><E><N><Q><R><A><H><L><L><D><N><T><E><R><L><E><R><S><S><R><R><L><E><A><G><Y><Q><I><A><V><E><T><E><Q><I><G><Q><E><M><L><E><N><L><S><H><D><R><E><K><I><Q><R><A><R><E><R><L><R><E><T><D><A><N><L><G><K><S><S><R><I><L><T><G><M><L><R><R><I><I><Q><N><R><I><L><L><V><I><L><G><I><I><V><V><I><T><I><L><M><A><I><T><F><S><V><R><R><H>
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.<BOP>
Q96AJ9
Q7RTN6
STRAA_HUMAN
Serologically defined breast cancer antigen NY-BR-96
Homo
<M><S><F><L><V><S><K><P><E><R><I><R><R><W><V><S><E><K><F><I><V><E><G><L><R><D><L><E><L><F><G><E><Q><P><P><G><D><T><R><R><K><T><N><D><A><S><S><E><S><I><A><S><F><S><K><Q><E><V><M><S><S><F><L><P><E><G><G><C><Y><E><L><L><T><V><I><G><K><G><F><E><D><L><M><T><V><N><L><A><R><Y><K><P><T><G><E><Y><V><T><V><R><R><I><N><L><E><A><C><S><N><E><M><V><T><F><L><Q><G><E><L><H><V><S><K><L><F><N><H><P><N><I><V><P><Y><R><A><T><F><I><A><D><N><E><L><W><V><V><T><S><F><M><A><Y><G><S><A><K><D><L><I><C><T><H><F><M><D><G><M><N><E><L><A><I><A><Y><I><L><Q><G><V><L><K><A><L><D><Y><I><H><H><M><G><Y><V><H><R><S><V><K><A><S><H><I><L><I><S><V><D><G><K><V><Y><L><S><G><L><R><S><N><L><S><M><I><S><H><G><Q><R><Q><R><V><V><H><D><F><P><K><Y><S><V><K><V><L><P><W><L><S><P><E><V><L><Q><Q><N><L><Q><G><Y><D><A><K><S><D><I><Y><S><V><G><I><T><A><C><E><L><A><N><G><H><V><P><F><K><D><M><P><A><T><Q><M><L><L><E><K><L><N><G><T><V><P><C><L><L><D><T><S><T><I><P><A><E><E><L><T><M><S><P><S><R><S><V><A><N><S><G><L><S><D><S><L><T><T><S><T><P><R><P><S><N><G><D><S><P><S><H><P><Y><H><R><T><F><S><P><H><F><H><H><F><V><E><Q><C><L><Q><R><N><P><D><A><R><P><S><A><S><T><L><L><N><H><S><F><F><K><Q><I><K><R><R><A><S><E><A><L><P><E><L><L><R><P><V><T><P><I><T><N><F><E><G><S><Q><S><Q><D><H><S><G><I><F><G><L><V><T><N><L><E><E><L><E><V><D><D><W><E><F>
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.<BOP>
Q7RTN6
Q6ZVT0
TTL10_HUMAN
Tubulin--tyrosine ligase-like protein 10
Homo
<M><D><H><S><C><T><R><F><I><H><R><R><G><P><P><T><R><T><R><A><G><F><K><R><G><K><R><P><R><I><Q><Q><R><P><R><A><R><V><S><G><T><I><P><A><S><R><L><H><P><A><P><A><S><Q><P><G><P><C><P><A><P><G><H><C><P><V><G><P><A><H><E><R><P><M><G><S><S><Q><E><E><G><L><R><C><Q><P><S><Q><P><D><H><D><A><D><G><H><C><G><P><D><L><E><G><A><E><R><A><S><A><T><P><G><P><P><G><L><L><N><S><H><R><P><A><D><S><D><D><T><N><A><A><G><P><S><A><A><L><L><E><G><L><L><L><G><G><G><K><P><S><P><H><S><T><R><P><G><P><F><F><Y><I><G><G><S><N><G><A><T><I><I><S><S><Y><C><K><S><K><G><W><Q><R><I><H><D><S><R><R><D><D><Y><T><L><K><W><C><E><V><K><S><R><D><S><Y><G><S><F><R><E><G><E><Q><L><L><Y><Q><L><P><N><N><K><L><L><T><T><K><I><G><L><L><S><T><L><R><G><R><A><R><A><M><S><K><A><S><K><V><P><G><G><V><Q><A><R><L><E><K><D><A><A><A><P><A><L><E><D><L><P><W><T><S><P><G><Y><L><R><P><Q><R><V><L><R><M><E><E><F><F><P><E><T><Y><R><L><D><L><K><H><E><R><E><A><F><F><T><L><F><D><E><T><Q><I><W><I><C><K><P><T><A><S><N><Q><G><K><G><I><F><L><L><R><N><Q><E><E><V><A><A><L><Q><A><K><T><R><S><M><E><D><D><P><I><H><H><K><T><P><F><R><G><P><Q><A><R><V><V><Q><R><Y><I><Q><N><P><L><L><V><D><G><R><K><F><D><V><R><S><Y><L><L><I><A><C><T><T><P><Y><M><I><F><F><G><H><G><Y><A><R><L><T><L><S><L><Y><D><P><H><S><S><D><L><G><G><H><L><T><N><Q><F><M><Q><K><K><S><P><L><Y><M><L><L><K><E><H><T><V><W><S><M><E><H><L><N><R><Y><I><S><D><T><F><W><K><A><R><G><L><A><K><D><W><V><F><T><T><L><K><K><R><M><Q><Q><I><M><A><H><C><F><L><A><A><K><P><K><L><D><C><K><L><G><Y><F><D><L><I><G><C><D><F><L><I><D><D><N><F><K><V><W><L><L><E><M><N><S><N><P><A><L><H><T><N><C><E><V><L><K><E><V><I><P><G><V><V><I><E><T><L><D><L><V><L><E><T><F><R><K><S><L><R><G><Q><K><M><L><P><L><L><S><Q><R><R><F><V><L><L><H><N><G><E><A><D><P><R><P><H><L><G><G><S><C><S><L><R><R><W><P><P><L><P><T><R><Q><A><K><S><S><G><P><P><M><P><H><A><P><D><Q><P><G><A><R><R><P><A><P><P><P><L><V><P><Q><R><P><R><P><P><G><P><D><L><D><S><A><H><D><G><E><P><Q><A><P><G><T><E><Q><S><G><T><G><N><R><H><P><A><Q><E><P><S><P><G><T><A><K><E><E><R><E><E><P><E><N><A><R><P>
Inactive polyglycylase.<BOP>
Q6ZVT0
Q8NH85
OR5R1_HUMAN
Olfactory receptor OR11-185
Homo
<M><A><E><V><N><I><I><Y><V><T><V><F><I><L><K><G><I><T><N><R><P><E><L><Q><A><P><C><F><G><V><F><L><V><I><Y><L><V><T><V><L><G><N><L><G><L><I><T><L><I><K><I><D><T><R><L><H><T><P><M><Y><Y><F><L><S><H><L><A><F><V><D><L><C><Y><S><S><A><I><T><P><K><M><M><V><N><F><V><V><E><R><N><T><I><P><F><H><A><C><A><T><Q><L><G><C><F><L><T><F><M><I><T><E><C><F><L><L><A><S><M><A><Y><D><C><Y><V><A><I><C><S><P><L><H><Y><S><T><L><M><S><R><R><V><C><I><Q><L><V><A><V><P><Y><I><Y><S><F><L><V><A><L><F><H><T><V><I><T><F><R><L><T><Y><C><G><P><N><L><I><N><H><F><Y><C><D><D><L><P><F><L><A><L><S><C><S><D><T><H><M><K><E><I><L><I><F><A><F><A><G><F><D><M><I><S><S><S><S><I><V><L><T><S><Y><I><F><I><I><A><A><I><L><R><I><R><S><T><Q><G><Q><H><K><A><I><S><T><C><G><S><H><M><V><T><V><T><I><F><Y><G><T><L><I><F><M><Y><L><Q><P><K><S><N><H><S><L><D><T><D><K><M><A><S><V><F><Y><T><V><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><K><D><A><S><K><K><A><L><D><K><G><C><E><N><L><Q><I><L><T><F><L><K><I><R><K><L><Y>
Odorant receptor.<BOP>
Q8NH85
Q14236
EPAG_HUMAN
DIAPH2 antisense gene protein 1
Homo
<M><N><L><Y><L><H><P><K><L><W><P><Q><L><A><G><T><K><T><L><H><V><A><D><A><Q><R><V><R><K><I><T><V><H><D><G><I><W><D><A><E><L><P><R><A><K><R><N><H><S><Y><H><L><R><Y><H><G><S><S><Y><S><R><C><F><L><E><R><Y><R><C><K><T><I><G><V><F><R><R><S><N><Q><P><D><C><L><E><T><R><S><E><K><A><K><N><R><D><G><V><V><Q><E><K><S><V><R><T><L><F><S><E><C><V><N><Q><C><D><I><R><R><R><P><T><R><F><L><R><M><F><Y><H><Q><K><H><F><Q><L><G><L><K><G><T><E><T><E><K><N><E><R><R><L>
May function as an early signal that helps mediate the activation of T-cells.<BOP>
Q14236
Q9Y3A5
SBDS_HUMAN
Shwachman-Bodian-Diamond syndrome protein
Homo
<M><S><I><F><T><P><T><N><Q><I><R><L><T><N><V><A><V><V><R><M><K><R><A><G><K><R><F><E><I><A><C><Y><K><N><K><V><V><G><W><R><S><G><V><E><K><D><L><D><E><V><L><Q><T><H><S><V><F><V><N><V><S><K><G><Q><V><A><K><K><E><D><L><I><S><A><F><G><T><D><D><Q><T><E><I><C><K><Q><I><L><T><K><G><E><V><Q><V><S><D><K><E><R><H><T><Q><L><E><Q><M><F><R><D><I><A><T><I><V><A><D><K><C><V><N><P><E><T><K><R><P><Y><T><V><I><L><I><E><R><A><M><K><D><I><H><Y><S><V><K><T><N><K><S><T><K><Q><Q><A><L><E><V><I><K><Q><L><K><E><K><M><K><I><E><R><A><H><M><R><L><R><F><I><L><P><V><N><E><G><K><K><L><K><E><K><L><K><P><L><I><K><V><I><E><S><E><D><Y><G><Q><Q><L><E><I><V><C><L><I><D><P><G><C><F><R><E><I><D><E><L><I><K><K><E><T><K><G><K><G><S><L><E><V><L><N><L><K><D><V><E><E><G><D><E><K><F><E>
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.<BOP>
Q9Y3A5
P18846
ATF1_HUMAN
Protein TREB36
Homo
<M><E><D><S><H><K><S><T><T><S><E><T><A><P><Q><P><G><S><A><V><Q><G><A><H><I><S><H><I><A><Q><Q><V><S><S><L><S><E><S><E><E><S><Q><D><S><S><D><S><I><G><S><S><Q><K><A><H><G><I><L><A><R><R><P><S><Y><R><K><I><L><K><D><L><S><S><E><D><T><R><G><R><K><G><D><G><E><N><S><G><V><S><A><A><V><T><S><M><S><V><P><T><P><I><Y><Q><T><S><S><G><Q><Y><I><A><I><A><P><N><G><A><L><Q><L><A><S><P><G><T><D><G><V><Q><G><L><Q><T><L><T><M><T><N><S><G><S><T><Q><Q><G><T><T><I><L><Q><Y><A><Q><T><S><D><G><Q><Q><I><L><V><P><S><N><Q><V><V><V><Q><T><A><S><G><D><M><Q><T><Y><Q><I><R><T><T><P><S><A><T><S><L><P><Q><T><V><V><M><T><S><P><V><T><L><T><S><Q><T><T><K><T><D><D><P><Q><L><K><R><E><I><R><L><M><K><N><R><E><A><A><R><E><C><R><R><K><K><K><E><Y><V><K><C><L><E><N><R><V><A><V><L><E><N><Q><N><K><T><L><I><E><E><L><K><T><L><K><D><L><Y><S><N><K><S><V>
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.<BOP>
P18846
Q9UI10
EI2BD_HUMAN
eIF-2B GDP-GTP exchange factor subunit delta
Homo
<M><A><A><V><A><V><A><V><R><E><D><S><G><S><G><M><K><A><E><L><P><P><G><P><G><A><V><G><R><E><M><T><K><E><E><K><L><Q><L><R><K><E><K><K><Q><Q><K><K><K><R><K><E><E><K><G><A><E><P><E><T><G><S><A><V><S><A><A><Q><C><Q><V><G><P><T><R><E><L><P><E><S><G><I><Q><L><G><T><P><R><E><K><V><P><A><G><R><S><K><A><E><L><R><A><E><R><R><A><K><Q><E><A><E><R><A><L><K><Q><A><R><K><G><E><Q><G><G><P><P><P><K><A><S><P><S><T><A><G><E><T><P><S><G><V><K><R><L><P><E><Y><P><Q><V><D><D><L><L><L><R><R><L><V><K><K><P><E><R><Q><Q><V><P><T><R><K><D><Y><G><S><K><V><S><L><F><S><H><L><P><Q><Y><S><R><Q><N><S><L><T><Q><F><M><S><I><P><S><S><V><I><H><P><A><M><V><R><L><G><L><Q><Y><S><Q><G><L><V><S><G><S><N><A><R><C><I><A><L><L><R><A><L><Q><Q><V><I><Q><D><Y><T><T><P><P><N><E><E><L><S><R><D><L><V><N><K><L><K><P><Y><M><S><F><L><T><Q><C><R><P><L><S><A><S><M><H><N><A><I><K><F><L><N><K><E><I><T><S><V><G><S><S><K><R><E><E><E><A><K><S><E><L><R><A><A><I><D><R><Y><V><Q><E><K><I><V><L><A><A><Q><A><I><S><R><F><A><Y><Q><K><I><S><N><G><D><V><I><L><V><Y><G><C><S><S><L><V><S><R><I><L><Q><E><A><W><T><E><G><R><R><F><R><V><V><V><V><D><S><R><P><W><L><E><G><R><H><T><L><R><S><L><V><H><A><G><V><P><A><S><Y><L><L><I><P><A><A><S><Y><V><L><P><E><V><S><K><V><L><L><G><A><H><A><L><L><A><N><G><S><V><M><S><R><V><G><T><A><Q><L><A><L><V><A><R><A><H><N><V><P><V><L><V><C><C><E><T><Y><K><F><C><E><R><V><Q><T><D><A><F><V><S><N><E><L><D><D><P><D><D><L><Q><C><K><R><G><E><H><V><A><L><A><N><W><Q><N><H><A><S><L><R><L><L><N><L><V><Y><D><V><T><P><P><E><L><V><D><L><V><I><T><E><L><G><M><I><P><C><S><S><V><P><V><V><L><R><V><K><S><S><D><Q>
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.<BOP>
Q9UI10
O76054
S14L2_HUMAN
Supernatant protein factor
Homo
<M><S><G><R><V><G><D><L><S><P><R><Q><K><E><A><L><A><K><F><R><E><N><V><Q><D><V><L><P><A><L><P><N><P><D><D><Y><F><L><L><R><W><L><R><A><R><S><F><D><L><Q><K><S><E><A><M><L><R><K><H><V><E><F><R><K><Q><K><D><I><D><N><I><I><S><W><Q><P><P><E><V><I><Q><Q><Y><L><S><G><G><M><C><G><Y><D><L><D><G><C><P><V><W><Y><D><I><I><G><P><L><D><A><K><G><L><L><F><S><A><S><K><Q><D><L><L><R><T><K><M><R><E><C><E><L><L><L><Q><E><C><A><H><Q><T><T><K><L><G><R><K><V><E><T><I><T><I><I><Y><D><C><E><G><L><G><L><K><H><L><W><K><P><A><V><E><A><Y><G><E><F><L><C><M><F><E><E><N><Y><P><E><T><L><K><R><L><F><V><V><K><A><P><K><L><F><P><V><A><Y><N><L><I><K><P><F><L><S><E><D><T><R><K><K><I><M><V><L><G><A><N><W><K><E><V><L><L><K><H><I><S><P><D><Q><V><P><V><E><Y><G><G><T><M><T><D><P><D><G><N><P><K><C><K><S><K><I><N><Y><G><G><D><I><P><R><K><Y><Y><V><R><D><Q><V><K><Q><Q><Y><E><H><S><V><Q><I><S><R><G><S><S><H><Q><V><E><Y><E><I><L><F><P><G><C><V><L><R><W><Q><F><M><S><D><G><A><D><V><G><F><G><I><F><L><K><T><K><M><G><E><R><Q><R><A><G><E><M><T><E><V><L><P><N><Q><R><Y><N><S><H><L><V><P><E><D><G><T><L><T><C><S><D><P><G><I><Y><V><L><R><F><D><N><T><Y><S><F><I><H><A><K><K><V><N><F><T><V><E><V><L><L><P><D><K><A><S><E><E><K><M><K><Q><L><G><A><G><T><P><K>
Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.<BOP>
O76054
P26885
FKBP2_HUMAN
Rotamase
Homo
<M><R><L><S><W><F><R><V><L><T><V><L><S><I><C><L><S><A><V><A><T><A><T><G><A><E><G><K><R><K><L><Q><I><G><V><K><K><R><V><D><H><C><P><I><K><S><R><K><G><D><V><L><H><M><H><Y><T><G><K><L><E><D><G><T><E><F><D><S><S><L><P><Q><N><Q><P><F><V><F><S><L><G><T><G><Q><V><I><K><G><W><D><Q><G><L><L><G><M><C><E><G><E><K><R><K><L><V><I><P><S><E><L><G><Y><G><E><R><G><A><P><P><K><I><P><G><G><A><T><L><V><F><E><V><E><L><L><K><I><E><R><R><T><E><L>
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<BOP>
P26885
Q13106
ZN154_HUMAN
Zinc finger protein 154
Homo
<M><A><A><A><T><L><R><T><P><T><Q><G><T><V><T><F><E><D><V><A><V><H><F><S><W><E><E><W><G><L><L><D><E><A><Q><R><C><L><Y><R><D><V><M><L><E><N><L><A><L><L><T><S><L><D><V><H><H><Q><K><Q><H><L><G><E><K><H><F><R><S><N><V><G><R><A><L><F><V><K><T><C><T><F><H><V><S><G><E><P><S><T><C><R><E><V><G><K><D><F><L><A><K><L><G><F><L><H><Q><Q><A><A><H><T><G><E><Q><S><N><S><K><S><D><G><G><A><I><S><H><R><G><K><T><H><Y><N><C><G><E><H><T><K><A><F><S><G><K><H><T><L><V><Q><Q><Q><R><T><L><T><T><E><R><C><Y><I><C><S><E><C><G><K><S><F><S><K><S><Y><S><L><N><D><H><W><R><L><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><S><F><R><Q><S><S><S><L><I><Q><H><R><R><V><H><T><A><V><R><P><H><E><C><D><E><C><G><K><L><F><S><N><K><S><N><L><I><K><H><R><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><Q><R><S><A><L><L><Q><H><R><G><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><F><F><T><Y><H><S><S><L><I><K><H><Q><K><V><H><S><G><S><R><P><Y><E><C><S><E><C><G><K><S><F><S><Q><N><S><S><L><I><E><H><H><R><V><H><T><G><E><R><P><Y><K><C><S><E><C><G><K><S><F><S><Q><R><S><A><L><L><Q><H><R><G><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><F><F><P><Y><S><S><S><L><R><K><H><Q><R><V><H><T><G><S><R><P><Y><E><C><S><E><C><G><K><S><F><T><Q><N><S><G><L><I><K><H><R><R><V><H><T><G><E><K><P><Y><E><C><T><E><C><G><K><S><F><S><H><N><S><S><L><I><K><H><Q><R><I><H><S><R>
May be involved in transcriptional regulation.<BOP>
Q13106
Q99623
PHB2_HUMAN
Repressor of estrogen receptor activity
Homo
<M><A><Q><N><L><K><D><L><A><G><R><L><P><A><G><P><R><G><M><G><T><A><L><K><L><L><L><G><A><G><A><V><A><Y><G><V><R><E><S><V><F><T><V><E><G><G><H><R><A><I><F><F><N><R><I><G><G><V><Q><Q><D><T><I><L><A><E><G><L><H><F><R><I><P><W><F><Q><Y><P><I><I><Y><D><I><R><A><R><P><R><K><I><S><S><P><T><G><S><K><D><L><Q><M><V><N><I><S><L><R><V><L><S><R><P><N><A><Q><E><L><P><S><M><Y><Q><R><L><G><L><D><Y><E><E><R><V><L><P><S><I><V><N><E><V><L><K><S><V><V><A><K><F><N><A><S><Q><L><I><T><Q><R><A><Q><V><S><L><L><I><R><R><E><L><T><E><R><A><K><D><F><S><L><I><L><D><D><V><A><I><T><E><L><S><F><S><R><E><Y><T><A><A><V><E><A><K><Q><V><A><Q><Q><E><A><Q><R><A><Q><F><L><V><E><K><A><K><Q><E><Q><R><Q><K><I><V><Q><A><E><G><E><A><E><A><A><K><M><L><G><E><A><L><S><K><N><P><G><Y><I><K><L><R><K><I><R><A><A><Q><N><I><S><K><T><I><A><T><S><Q><N><R><I><Y><L><T><A><D><N><L><V><L><N><L><Q><D><E><S><F><T><R><G><S><D><S><L><I><K><G><K><K>
(Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection.<BOP>
Q99623
Q9UI30
TR112_HUMAN
tRNA methyltransferase 112 homolog
Homo
<M><K><L><L><T><H><N><L><L><S><S><H><V><R><G><V><G><S><R><G><F><P><L><R><L><Q><A><T><E><V><R><I><C><P><V><E><F><N><P><N><F><V><A><R><M><I><P><K><V><E><W><S><A><F><L><E><A><A><D><N><L><R><L><I><Q><V><P><K><G><P><V><E><G><Y><E><E><N><E><E><F><L><R><T><M><H><H><L><L><L><E><V><E><V><I><E><G><T><L><Q><C><P><E><S><G><R><M><F><P><I><S><R><G><I><P><N><M><L><L><S><E><E><E><T><E><S>
Acts as an activator of both rRNA/tRNA and protein methyltransferases . Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA . The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor . The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) . The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species . Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production
Q9UI30
Q9P2X7
DEC1_HUMAN
Candidate tumor suppressor CTS9
Homo
<M><T><M><N><V><L><E><A><G><K><W><K><S><I><V><P><A><P><G><E><G><L><L><A><V><L><H><M><M><V><F><T><D><A><L><H><R><E><R><S><V><K><W><Q><A><G><V><C><Y><N><G><G><K><D><F><A><V><S><L><A><R><P><K><A><A><E><G><I><A><D>
Candidate tumor suppressor.<BOP>
Q9P2X7
Q5JPI3
CC038_HUMAN
Uncharacterized protein C3orf38
Homo
<M><E><M><S><G><L><S><F><S><E><M><E><G><C><R><N><L><L><G><L><L><D><N><D><E><I><M><A><L><C><D><T><V><T><N><R><L><V><Q><P><Q><D><R><Q><D><A><V><H><A><I><L><A><Y><S><Q><S><A><E><E><L><L><R><R><R><K><V><H><R><E><V><I><F><K><Y><L><A><T><Q><G><I><V><I><P><P><A><T><E><K><H><N><L><I><Q><H><A><K><D><Y><W><Q><K><Q><P><Q><L><K><L><K><E><T><P><E><P><V><T><K><T><E><D><I><H><L><F><Q><Q><Q><V><K><E><D><K><K><A><E><K><V><D><F><R><R><L><G><E><E><F><C><H><W><F><F><G><L><L><N><S><Q><N><P><F><L><G><P><P><Q><D><E><W><G><P><Q><H><F><W><H><D><V><K><L><R><F><Y><Y><N><T><S><E><Q><N><V><M><D><Y><H><G><A><E><I><V><S><L><R><L><L><S><L><V><K><E><E><F><L><F><L><S><P><N><L><D><S><H><G><L><K><C><A><S><S><P><H><G><L><V><M><V><G><V><A><G><T><V><H><R><G><N><T><C><L><G><I><F><E><Q><I><F><G><L><I><R><C><P><F><V><E><N><T><W><K><I><K><F><I><N><L><K><I><M><G><E><S><S><L><A><P><G><T><L><P><K><P><S><V><K><F><E><Q><S><D><L><E><A><F><Y><N><V><I><T><V><C><G><T><N><E><V><R><H><N><V><K><Q><A><S><D><S><G><T><G><D><Q><V>
May be involved in apoptosis regulation.<BOP>
Q5JPI3
Q9NZP2
OR6C2_HUMAN
HSA3
Homo
<M><K><N><H><T><V><I><R><T><F><I><L><L><G><L><T><G><D><P><H><L><Q><V><L><L><F><I><F><L><F><L><T><Y><M><L><S><V><T><G><N><L><T><I><I><T><L><T><L><V><D><H><H><L><K><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><V><S><F><T><T><V><C><I><P><R><F><L><Y><N><I><S><M><G><D><N><T><I><T><Y><N><A><C><A><S><Q><I><F><F><V><I><L><F><G><A><T><E><F><F><L><L><A><A><M><S><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><V><V><I><M><N><N><R><V><C><T><L><L><V><L><C><C><W><V><A><G><L><M><I><I><V><P><P><L><S><L><G><L><Q><L><E><F><C><D><S><N><A><I><D><H><F><S><C><D><A><G><P><L><L><K><I><S><C><S><D><T><W><V><I><E><Q><M><V><I><L><M><A><V><F><A><L><I><I><T><L><V><C><V><I><L><S><Y><L><Y><I><V><R><T><I><L><K><F><P><S><V><Q><Q><R><K><K><A><F><S><T><C><S><S><H><M><I><V><V><S><I><A><Y><G><S><C><I><F><I><Y><I><K><P><S><A><K><D><E><V><A><I><N><K><G><V><S><V><L><T><T><S><V><A><P><L><L><N><P><F><I><Y><T><L><R><N><K><Q><V><K><Q><A><F><S><D><S><I><K><R><I><A><F><L><S><K><K>
Odorant receptor.<BOP>
Q9NZP2
Q96PM5
ZN363_HUMAN
p53-induced RING-H2 protein
Homo
<M><A><A><T><A><R><E><D><G><A><S><G><Q><E><R><G><Q><R><G><C><E><H><Y><D><R><G><C><L><L><K><A><P><C><C><D><K><L><Y><T><C><R><L><C><H><D><N><N><E><D><H><Q><L><D><R><F><K><V><K><E><V><Q><C><I><N><C><E><K><I><Q><H><A><Q><Q><T><C><E><E><C><S><T><L><F><G><E><Y><Y><C><D><I><C><H><L><F><D><K><D><K><K><Q><Y><H><C><E><N><C><G><I><C><R><I><G><P><K><E><D><F><F><H><C><L><K><C><N><L><C><L><A><M><N><L><Q><G><R><H><K><C><I><E><N><V><S><R><Q><N><C><P><I><C><L><E><D><I><H><T><S><R><V><V><A><H><V><L><P><C><G><H><L><L><H><R><T><C><Y><E><E><M><L><K><E><G><Y><R><C><P><L><C><M><H><S><A><L><D><M><T><R><Y><W><R><Q><L><D><D><E><V><A><Q><T><P><M><P><S><E><Y><Q><N><M><T><V><D><I><L><C><N><D><C><N><G><R><S><T><V><Q><F><H><I><L><G><M><K><C><K><I><C><E><S><Y><N><T><A><Q><A><G><G><R><R><I><S><L><D><Q><Q>
Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.<BOP>
Q96PM5
Q9H9Y4
GPN2_HUMAN
ATP-binding domain 1 family member B
Homo
<M><A><G><A><A><P><T><T><A><F><G><Q><A><V><I><G><P><P><G><S><G><K><T><T><Y><C><L><G><M><S><E><F><L><R><A><L><G><R><R><V><A><V><V><N><L><D><P><A><N><E><G><L><P><Y><E><C><A><V><D><V><G><E><L><V><G><L><G><D><V><M><D><A><L><R><L><G><P><N><G><G><L><L><Y><C><M><E><Y><L><E><A><N><L><D><W><L><R><A><K><L><D><P><L><R><G><H><Y><F><L><F><D><C><P><G><Q><V><E><L><C><T><H><H><G><A><L><R><S><I><F><S><Q><M><A><Q><W><D><L><R><L><T><A><V><H><L><V><D><S><H><Y><C><T><D><P><A><K><F><I><S><V><L><C><T><S><L><A><T><M><L><H><V><E><L><P><H><I><N><L><L><S><K><M><D><L><I><E><H><Y><G><K><L><A><F><N><L><D><Y><Y><T><E><V><L><D><L><S><Y><L><L><D><H><L><A><S><D><P><F><F><R><H><Y><R><Q><L><N><E><K><L><V><Q><L><I><E><D><Y><S><L><V><S><F><I><P><L><N><I><Q><D><K><E><S><I><Q><R><V><L><Q><A><V><D><K><A><N><G><Y><C><F><R><A><Q><E><Q><R><S><L><E><A><M><M><S><A><A><M><G><A><D><F><H><F><S><S><T><L><G><I><Q><E><K><Y><L><A><P><S><N><Q><S><V><E><Q><E><A><M><Q><L>
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.<BOP>
Q9H9Y4
P50440
GATM_HUMAN
Transamidinase
Homo
<M><L><R><V><R><C><L><R><G><G><S><R><G><A><E><A><V><H><Y><I><G><S><R><L><G><R><T><L><T><G><W><V><Q><R><T><F><Q><S><T><Q><A><A><T><A><S><S><R><N><S><C><A><A><D><D><K><A><T><E><P><L><P><K><D><C><P><V><S><S><Y><N><E><W><D><P><L><E><E><V><I><V><G><R><A><E><N><A><C><V><P><P><F><T><I><E><V><K><A><N><T><Y><E><K><Y><W><P><F><Y><Q><K><Q><G><G><H><Y><F><P><K><D><H><L><K><K><A><V><A><E><I><E><E><M><C><N><I><L><K><T><E><G><V><T><V><R><R><P><D><P><I><D><W><S><L><K><Y><K><T><P><D><F><E><S><T><G><L><Y><S><A><M><P><R><D><I><L><I><V><V><G><N><E><I><I><E><A><P><M><A><W><R><S><R><F><F><E><Y><R><A><Y><R><S><I><I><K><D><Y><F><H><R><G><A><K><W><T><T><A><P><K><P><T><M><A><D><E><L><Y><N><Q><D><Y><P><I><H><S><V><E><D><R><H><K><L><A><A><Q><G><K><F><V><T><T><E><F><E><P><C><F><D><A><A><D><F><I><R><A><G><R><D><I><F><A><Q><R><S><Q><V><T><N><Y><L><G><I><E><W><M><R><R><H><L><A><P><D><Y><R><V><H><I><I><S><F><K><D><P><N><P><M><H><I><D><A><T><F><N><I><I><G><P><G><I><V><L><S><N><P><D><R><P><C><H><Q><I><D><L><F><K><K><A><G><W><T><I><I><T><P><P><T><P><I><I><P><D><D><H><P><L><W><M><S><S><K><W><L><S><M><N><V><L><M><L><D><E><K><R><V><M><V><D><A><N><E><V><P><I><Q><K><M><F><E><K><L><G><I><T><T><I><K><V><N><I><R><N><A><N><S><L><G><G><G><F><H><C><W><T><C><D><V><R><R><R><G><T><L><Q><S><Y><L><D>
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.<BOP>
P50440
Q969E1
LEAP2_HUMAN
Liver-expressed antimicrobial peptide 2
Homo
<M><W><H><L><K><L><C><A><V><L><M><I><F><L><L><L><L><G><Q><I><D><G><S><P><I><P><E><V><S><S><A><K><R><R><P><R><R><M><T><P><F><W><R><G><V><S><L><R><P><I><G><A><S><C><R><D><D><S><E><C><I><T><R><L><C><R><K><R><R><C><S><L><S><V><A><Q><E>
Has an antimicrobial activity.<BOP>
Q969E1
P09681
GIP_HUMAN
Incretin hormone
Homo
<M><V><A><T><K><T><F><A><L><L><L><L><S><L><F><L><A><V><G><L><G><E><K><K><E><G><H><F><S><A><L><P><S><L><P><V><G><S><H><A><K><V><S><S><P><Q><P><R><G><P><R><Y><A><E><G><T><F><I><S><D><Y><S><I><A><M><D><K><I><H><Q><Q><D><F><V><N><W><L><L><A><Q><K><G><K><K><N><D><W><K><H><N><I><T><Q><R><E><A><R><A><L><E><L><A><S><Q><A><N><R><K><E><E><E><A><V><E><P><Q><S><S><P><A><K><N><P><S><D><E><D><L><L><R><D><L><L><I><Q><E><L><L><A><C><L><L><D><Q><T><N><L><C><R><L><R><S><R>
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.<BOP>
P09681
Q96A23
CPNE4_HUMAN
Copine-8
Homo
<M><K><K><M><S><N><I><Y><E><S><A><A><N><T><L><G><I><F><N><S><P><C><L><T><K><V><E><L><R><V><A><C><K><G><I><S><D><R><D><A><L><S><K><P><D><P><C><V><I><L><K><M><Q><S><H><G><Q><W><F><E><V><D><R><T><E><V><I><R><T><C><I><N><P><V><Y><S><K><L><F><T><V><D><F><Y><F><E><E><V><Q><R><L><R><F><E><V><H><D><I><S><S><N><H><N><G><L><K><E><A><D><F><L><G><G><M><E><C><T><L><G><Q><I><V><S><Q><R><K><L><S><K><S><L><L><K><H><G><N><T><A><G><K><S><S><I><T><V><I><A><E><E><L><S><G><N><D><D><Y><V><E><L><A><F><N><A><R><K><L><D><D><K><D><F><F><S><K><S><D><P><F><L><E><I><F><R><M><N><D><D><A><T><Q><Q><L><V><H><R><T><E><V><V><M><N><N><L><S><P><A><W><K><S><F><K><V><S><V><N><S><L><C><S><G><D><P><D><R><R><L><K><C><I><V><W><D><W><D><S><N><G><K><H><D><F><I><G><E><F><T><S><T><F><K><E><M><R><G><A><M><E><G><K><Q><V><Q><W><E><C><I><N><P><K><Y><K><A><K><K><K><N><Y><K><N><S><G><T><V><I><L><N><L><C><K><I><H><K><M><H><S><F><L><D><Y><I><M><G><G><C><Q><I><Q><F><T><V><A><I><D><F><T><A><S><N><G><D><P><R><N><S><C><S><L><H><Y><I><H><P><Y><Q><P><N><E><Y><L><K><A><L><V><A><V><G><E><I><C><Q><D><Y><D><S><D><K><M><F><P><A><F><G><F><G><A><R><I><P><P><E><Y><T><V><S><H><D><F><A><I><N><F><N><E><D><N><P><E><C><A><G><I><Q><G><V><V><E><A><Y><Q><S><C><L><P><K><L><Q><L><Y><G><P><T><N><I><A><P><I><I><Q><K><V><A><K><S><A><S><E><E><T><N><T><K><E><A><S><Q><Y><F><I><L><L><I><L><T><D><G><V><I><T><D><M><A><D><T><R><E><A><I><V><H><A><S><H><L><P><M><S><V><I><I><V><G><V><G><N><A><D><F><S><D><M><Q><M><L><D><G><D><D><G><I><L><R><S><P><K><G><E><P><V><L><R><D><I><V><Q><F><V><P><F><R><N><F><K><H><A><S><P><A><A><L><A><K><S><V><L><A><E><V><P><N><Q><V><V><D><Y><Y><N><G><K><G><I><K><P><K><C><S><S><E><M><Y><E><S><S><R><T><L><A><P>
Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.<BOP>
Q96A23
Q8IZR5
CKLF4_HUMAN
Chemokine-like factor superfamily member 4
Homo
<M><R><S><G><E><E><L><D><G><F><E><G><E><A><S><S><T><S><M><I><S><G><A><S><S><P><Y><Q><P><T><T><E><P><V><S><Q><R><R><G><L><A><G><L><R><C><D><P><D><Y><L><R><G><A><L><G><R><L><K><V><A><Q><V><I><L><A><L><I><A><F><I><C><I><E><T><I><M><A><C><S><P><C><E><G><L><Y><F><F><E><F><V><S><C><S><A><F><V><V><T><G><V><L><L><I><M><F><S><L><N><L><H><M><R><I><P><Q><I><N><W><N><L><T><D><L><V><N><T><G><L><S><A><F><L><F><F><I><A><S><I><V><L><A><A><L><N><H><R><A><G><A><E><I><A><A><V><I><F><G><F><L><A><T><A><A><Y><A><V><N><T><F><L><A><V><Q><K><W><R><V><S><V><R><Q><Q><S><T><N><D><Y><I><R><A><R><T><E><S><R><D><V><D><S><R><P><E><I><Q><R><L><D><T><F><S><Y><S><T><N><V><T><V><R><K><K><S><P><T><N><L><L><S><L><N><H><W><Q><L><A>
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.<BOP>
Q8IZR5
P23142
FBLN1_HUMAN
Fibulin-1
Homo
<M><E><R><A><A><P><S><R><R><V><P><L><P><L><L><L><L><G><G><L><A><L><L><A><A><G><V><D><A><D><V><L><L><E><A><C><C><A><D><G><H><R><M><A><T><H><Q><K><D><C><S><L><P><Y><A><T><E><S><K><E><C><R><M><V><Q><E><Q><C><C><H><S><Q><L><E><E><L><H><C><A><T><G><I><S><L><A><N><E><Q><D><R><C><A><T><P><H><G><D><N><A><S><L><E><A><T><F><V><K><R><C><C><H><C><C><L><L><G><R><A><A><Q><A><Q><G><Q><S><C><E><Y><S><L><M><V><G><Y><Q><C><G><Q><V><F><Q><A><C><C><V><K><S><Q><E><T><G><D><L><D><V><G><G><L><Q><E><T><D><K><I><I><E><V><E><E><E><Q><E><D><P><Y><L><N><D><R><C><R><G><G><G><P><C><K><Q><Q><C><R><D><T><G><D><E><V><V><C><S><C><F><V><G><Y><Q><L><L><S><D><G><V><S><C><E><D><V><N><E><C><I><T><G><S><H><S><C><R><L><G><E><S><C><I><N><T><V><G><S><F><R><C><Q><R><D><S><S><C><G><T><G><Y><E><L><T><E><D><N><S><C><K><D><I><D><E><C><E><S><G><I><H><N><C><L><P><D><F><I><C><Q><N><T><L><G><S><F><R><C><R><P><K><L><Q><C><K><S><G><F><I><Q><D><A><L><G><N><C><I><D><I><N><E><C><L><S><I><S><A><P><C><P><I><G><H><T><C><I><N><T><E><G><S><Y><T><C><Q><K><N><V><P><N><C><G><R><G><Y><H><L><N><E><E><G><T><R><C><V><D><V><D><E><C><A><P><P><A><E><P><C><G><K><G><H><R><C><V><N><S><P><G><S><F><R><C><E><C><K><T><G><Y><Y><F><D><G><I><S><R><M><C><V><D><V><N><E><C><Q><R><Y><P><G><R><L><C><G><H><K><C><E><N><T><L><G><S><Y><L><C><S><C><S><V><G><F><R><L><S><V><D><G><R><S><C><E><D><I><N><E><C><S><S><S><P><C><S><Q><E><C><A><N><V><Y><G><S><Y><Q><C><Y><C><R><R><G><Y><Q><L><S><D><V><D><G><V><T><C><E><D><I><D><E><C><A><L><P><T><G><G><H><I><C><S><Y><R><C><I><N><I><P><G><S><F><Q><C><S><C><P><S><S><G><Y><R><L><A><P><N><G><R><N><C><Q><D><I><D><E><C><V><T><G><I><H><N><C><S><I><N><E><T><C><F><N><I><Q><G><G><F><R><C><L><A><F><E><C><P><E><N><Y><R><R><S><A><A><T><L><Q><Q><E><K><T><D><T><V><R><C><I><K><S><C><R><P><N><D><V><T><C><V><F><D><P><V><H><T><I><S><H><T><V><I><S><L><P><T><F><R><E><F><T><R><P><E><E><I><I><F><L><R><A><I><T><P><P><H><P><A><S><Q><A><N><I><I><F><D><I><T><E><G><N><L><R><D><S><F><D><I><I><K><R><Y><M><D><G><M><T><V><G><V><V><R><Q><V><R><P><I><V><G><P><F><H><A><V><L><K><L><E><M><N><Y><V><V><G><G><V><V><S><H><R><N><V><V><N><V><H><I><F><V><S><E><Y><W><F>
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.<BOP>
P23142
Q9Y253
POLH_HUMAN
Xeroderma pigmentosum variant type protein
Homo
<M><A><T><G><Q><D><R><V><V><A><L><V><D><M><D><C><F><F><V><Q><V><E><Q><R><Q><N><P><H><L><R><N><K><P><C><A><V><V><Q><Y><K><S><W><K><G><G><G><I><I><A><V><S><Y><E><A><R><A><F><G><V><T><R><S><M><W><A><D><D><A><K><K><L><C><P><D><L><L><L><A><Q><V><R><E><S><R><G><K><A><N><L><T><K><Y><R><E><A><S><V><E><V><M><E><I><M><S><R><F><A><V><I><E><R><A><S><I><D><E><A><Y><V><D><L><T><S><A><V><Q><E><R><L><Q><K><L><Q><G><Q><P><I><S><A><D><L><L><P><S><T><Y><I><E><G><L><P><Q><G><P><T><T><A><E><E><T><V><Q><K><E><G><M><R><K><Q><G><L><F><Q><W><L><D><S><L><Q><I><D><N><L><T><S><P><D><L><Q><L><T><V><G><A><V><I><V><E><E><M><R><A><A><I><E><R><E><T><G><F><Q><C><S><A><G><I><S><H><N><K><V><L><A><K><L><A><C><G><L><N><K><P><N><R><Q><T><L><V><S><H><G><S><V><P><Q><L><F><S><Q><M><P><I><R><K><I><R><S><L><G><G><K><L><G><A><S><V><I><E><I><L><G><I><E><Y><M><G><E><L><T><Q><F><T><E><S><Q><L><Q><S><H><F><G><E><K><N><G><S><W><L><Y><A><M><C><R><G><I><E><H><D><P><V><K><P><R><Q><L><P><K><T><I><G><C><S><K><N><F><P><G><K><T><A><L><A><T><R><E><Q><V><Q><W><W><L><L><Q><L><A><Q><E><L><E><E><R><L><T><K><D><R><N><D><N><D><R><V><A><T><Q><L><V><V><S><I><R><V><Q><G><D><K><R><L><S><S><L><R><R><C><C><A><L><T><R><Y><D><A><H><K><M><S><H><D><A><F><T><V><I><K><N><C><N><T><S><G><I><Q><T><E><W><S><P><P><L><T><M><L><F><L><C><A><T><K><F><S><A><S><A><P><S><S><S><T><D><I><T><S><F><L><S><S><D><P><S><S><L><P><K><V><P><V><T><S><S><E><A><K><T><Q><G><S><G><P><A><V><T><A><T><K><K><A><T><T><S><L><E><S><F><F><Q><K><A><A><E><R><Q><K><V><K><E><A><S><L><S><S><L><T><A><P><T><Q><A><P><M><S><N><S><P><S><K><P><S><L><P><F><Q><T><S><Q><S><T><G><T><E><P><F><F><K><Q><K><S><L><L><L><K><Q><K><Q><L><N><N><S><S><V><S><S><P><Q><Q><N><P><W><S><N><C><K><A><L><P><N><S><L><P><T><E><Y><P><G><C><V><P><V><C><E><G><V><S><K><L><E><E><S><S><K><A><T><P><A><E><M><D><L><A><H><N><S><Q><S><M><H><A><S><S><A><S><K><S><V><L><E><V><T><Q><K><A><T><P><N><P><S><L><L><A><A><E><D><Q><V><P><C><E><K><C><G><S><L><V><P><V><W><D><M><P><E><H><M><D><Y><H><F><A><L><E><L><Q><K><S><F><L><Q><P><H><S><S><N><P><Q><V><V><S><A><V><S><H><Q><G><K><R><N><P><K><S><P><L><A><C><T><N><K><R><P><R><P><E><G><M><Q><T><L><E><S><F><F><K><P><L><T><H>
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) . Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine . Particularly important for the repair of UV-induced pyrimidine dimers . Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes . Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue. This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis .
Q9Y253
P32314
FOXN2_HUMAN
Human T-cell leukemia virus enhancer factor
Homo
<M><G><P><V><I><G><M><T><P><D><K><R><A><E><T><P><G><A><E><K><I><A><G><L><S><Q><I><Y><K><M><G><S><L><P><E><A><V><D><A><A><R><P><K><A><T><L><V><D><S><E><S><A><D><D><E><L><T><N><L><N><W><L><H><E><S><T><N><L><L><T><N><F><S><L><G><S><E><G><L><P><I><V><S><P><L><Y><D><I><E><G><D><D><V><P><S><F><G><P><A><C><Y><Q><N><P><E><K><K><S><A><T><S><K><P><P><Y><S><F><S><L><L><I><Y><M><A><I><E><H><S><P><N><K><C><L><P><V><K><E><I><Y><S><W><I><L><D><H><F><P><Y><F><A><T><A><P><T><G><W><K><N><S><V><R><H><N><L><S><L><N><K><C><F><Q><K><V><E><R><S><H><G><K><V><N><G><K><G><S><L><W><C><V><D><P><E><Y><K><P><N><L><I><Q><A><L><K><K><Q><P><F><S><S><A><S><S><Q><N><G><S><L><S><P><H><Y><L><S><S><V><I><K><Q><N><Q><V><R><N><L><K><E><S><D><I><D><A><A><A><A><M><M><L><L><N><T><S><I><E><Q><G><I><L><E><C><E><K><P><L><P><L><K><T><A><L><Q><K><K><R><S><Y><G><N><A><F><H><H><P><S><A><V><R><L><Q><E><S><D><S><L><A><T><S><I><D><P><K><E><D><H><N><Y><S><A><S><S><M><A><A><Q><R><C><A><S><R><S><S><V><S><S><L><S><S><V><D><E><V><Y><E><F><I><P><K><N><S><H><V><G><S><D><G><S><E><G><F><H><S><E><E><D><T><D><V><D><Y><E><D><D><P><L><G><D><S><G><Y><A><S><Q><P><C><A><K><I><S><E><K><G><Q><S><G><K><K><M><R><K><Q><T><C><Q><E><I><D><E><E><L><K><E><A><A><G><S><L><L><H><L><A><G><I><R><T><C><L><G><S><L><I><S><T><A><K><T><Q><N><Q><K><Q><R><K><K>
Binds to the purine-rich region in HTLV-I LTR.<BOP>
P32314
Q96MP8
KCTD7_HUMAN
BTB/POZ domain-containing protein KCTD7
Homo
<M><V><V><V><T><G><R><E><P><D><S><R><R><Q><D><G><A><M><S><S><S><D><A><E><D><D><F><L><E><P><A><T><P><T><A><T><Q><A><G><H><A><L><P><L><L><P><Q><E><F><P><E><V><V><P><L><N><I><G><G><A><H><F><T><T><R><L><S><T><L><R><C><Y><E><D><T><M><L><A><A><M><F><S><G><R><H><Y><I><P><T><D><S><E><G><R><Y><F><I><D><R><D><G><T><H><F><G><D><V><L><N><F><L><R><S><G><D><L><P><P><R><E><R><V><R><A><V><Y><K><E><A><Q><Y><Y><A><I><G><P><L><L><E><Q><L><E><N><M><Q><P><L><K><G><E><K><V><R><Q><A><F><L><G><L><M><P><Y><Y><K><D><H><L><E><R><I><V><E><I><A><R><L><R><A><V><Q><R><K><A><R><F><A><K><L><K><V><C><V><F><K><E><E><M><P><I><T><P><Y><E><C><P><L><L><N><S><L><R><F><E><R><S><E><S><D><G><Q><L><F><E><H><H><C><E><V><D><V><S><F><G><P><W><E><A><V><A><D><V><Y><D><L><L><H><C><L><V><T><D><L><S><A><Q><G><L><T><V><D><H><Q><C><I><G><V><C><D><K><H><L><V><N><H><Y><Y><C><K><R><P><I><Y><E><F><K><I><T><W><W>
May be involved in the control of excitability of cortical neurons.<BOP>
Q96MP8
Q8IXF9
AQ12A_HUMAN
Aquaporin-12A
Homo
<M><A><G><L><N><V><S><L><S><F><F><F><A><T><F><A><L><C><E><A><A><R><R><A><S><K><A><L><L><P><V><G><A><Y><E><V><F><A><R><E><A><M><R><T><L><V><E><L><G><P><W><A><G><D><F><G><P><D><L><L><L><T><L><L><F><L><L><F><L><A><H><G><V><T><L><D><G><A><S><A><N><P><T><V><S><L><Q><E><F><L><M><A><E><Q><S><L><P><G><T><L><L><K><L><A><A><Q><G><L><G><M><Q><A><A><C><T><L><M><R><L><C><W><A><W><E><L><S><D><L><H><L><L><Q><S><L><M><A><Q><S><C><S><S><A><L><R><T><S><V><P><H><G><A><L><V><E><A><A><C><A><F><C><F><H><L><T><L><L><H><L><R><H><S><P><P><A><Y><S><G><P><A><V><A><L><L><V><T><V><T><A><Y><T><A><G><P><F><T><S><A><F><F><N><P><A><L><A><A><S><V><T><F><A><C><S><G><H><T><L><L><E><Y><V><Q><V><Y><W><L><G><P><L><T><G><M><V><L><A><V><L><L><H><Q><G><R><L><P><H><L><F><Q><R><N><L><F><Y><G><Q><K><N><K><Y><R><A><P><R><G><K><P><A><P><A><S><G><D><T><Q><T><P><A><K><G><S><S><V><R><E><P><G><R><S><G><V><E><G><P><H><S><S>
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.<BOP>
Q8IXF9
Q86SK9
SCD5_HUMAN
Stearoyl-CoA desaturase 2
Homo
<M><P><G><P><A><T><D><A><G><K><I><P><F><C><D><A><K><E><E><I><R><A><G><L><E><S><S><E><G><G><G><G><P><E><R><P><G><A><R><G><Q><R><Q><N><I><V><W><R><N><V><V><L><M><S><L><L><H><L><G><A><V><Y><S><L><V><L><I><P><K><A><K><P><L><T><L><L><W><A><Y><F><C><F><L><L><A><A><L><G><V><T><A><G><A><H><R><L><W><S><H><R><S><Y><R><A><K><L><P><L><R><I><F><L><A><V><A><N><S><M><A><F><Q><N><D><I><F><E><W><S><R><D><H><R><A><H><H><K><Y><S><E><T><D><A><D><P><H><N><A><R><R><G><F><F><F><S><H><I><G><W><L><F><V><R><K><H><R><D><V><I><E><K><G><R><K><L><D><V><T><D><L><L><A><D><P><V><V><R><I><Q><R><K><Y><Y><K><I><S><V><V><L><M><C><F><V><V><P><T><L><V><P><W><Y><I><W><G><E><S><L><W><N><S><Y><F><L><A><S><I><L><R><Y><T><I><S><L><N><I><S><W><L><V><N><S><A><A><H><M><Y><G><N><R><P><Y><D><K><H><I><S><P><R><Q><N><P><L><V><A><L><G><A><I><G><E><G><F><H><N><Y><H><H><T><F><P><F><D><Y><S><A><S><E><F><G><L><N><F><N><P><T><T><W><F><I><D><F><M><C><W><L><G><L><A><T><D><R><K><R><A><T><K><P><M><I><E><A><R><K><A><R><T><G><D><S><S><A>
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA . Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids . Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways .<BOP>
Q86SK9
Q3SY84
K2C71_HUMAN
Type-II keratin Kb34
Homo
<M><S><R><Q><F><T><C><K><S><G><A><A><A><K><G><G><F><S><G><C><S><A><V><L><S><G><G><S><S><S><S><F><R><A><G><S><K><G><L><S><G><G><F><G><S><R><S><L><Y><S><L><G><G><V><R><S><L><N><V><A><S><G><S><G><K><S><G><G><Y><G><F><G><R><G><R><A><S><G><F><A><G><S><M><F><G><S><V><A><L><G><P><V><C><P><T><V><C><P><P><G><G><I><H><Q><V><T><V><N><E><S><L><L><A><P><L><N><V><E><L><D><P><E><I><Q><K><V><R><A><Q><E><R><E><Q><I><K><A><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><Q><V><L><E><T><K><W><E><L><L><Q><Q><L><D><L><N><N><C><K><N><N><L><E><P><I><L><E><G><Y><I><S><N><L><R><K><Q><L><E><T><L><S><G><D><R><V><R><L><D><S><E><L><R><N><V><R><D><V><V><E><D><Y><K><K><R><Y><E><E><E><I><N><K><R><T><A><A><E><N><E><F><V><L><L><K><K><D><V><D><A><A><Y><A><N><K><V><E><L><Q><A><K><V><E><S><M><D><Q><E><I><K><F><F><R><C><L><F><E><A><E><I><T><Q><I><Q><S><H><I><S><D><M><S><V><I><L><S><M><D><N><N><R><N><L><D><L><D><S><I><I><D><E><V><R><T><Q><Y><E><E><I><A><L><K><S><K><A><E><A><E><A><L><Y><Q><T><K><F><Q><E><L><Q><L><A><A><G><R><H><G><D><D><L><K><N><T><K><N><E><I><S><E><L><T><R><L><I><Q><R><I><R><S><E><I><E><N><V><K><K><Q><A><S><N><L><E><T><A><I><A><D><A><E><Q><R><G><D><N><A><L><K><D><A><R><A><K><L><D><E><L><E><G><A><L><H><Q><A><K><E><E><L><A><R><M><L><R><E><Y><Q><E><L><M><S><L><K><L><A><L><D><M><E><I><A><T><Y><R><K><L><L><E><S><E><E><C><R><M><S><G><E><F><P><S><P><V><S><I><S><I><I><S><S><T><S><G><G><S><V><Y><G><F><R><P><S><M><V><S><G><G><Y><V><A><N><S><S><N><C><I><S><G><V><C><S><V><R><G><G><E><G><R><S><R><G><S><A><N><D><Y><K><D><T><L><G><K><G><S><S><L><S><A><P><S><K><K><T><S><R>
Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.<BOP>
Q3SY84
Q0P5N6
ARL16_HUMAN
ADP-ribosylation factor-like protein 16
Homo
<M><R><V><A><G><G><R><A><L><S><R><G><A><E><L><R><V><P><G><G><A><K><H><G><M><C><L><L><L><G><A><T><G><V><G><K><T><L><L><V><K><R><L><Q><E><V><S><S><R><D><G><K><G><D><L><G><E><P><P><P><T><R><P><T><V><G><T><N><L><T><D><I><V><A><Q><R><K><I><T><I><R><E><L><G><G><C><M><G><P><I><W><S><S><Y><Y><G><N><C><R><S><L><L><F><V><M><D><A><S><D><P><T><Q><L><S><A><S><C><V><Q><L><L><G><L><L><S><A><E><Q><L><A><E><A><S><V><L><I><L><F><N><K><I><D><L><P><C><Y><M><S><T><E><E><M><K><S><L><I><R><L><P><D><I><I><A><C><A><K><Q><N><I><T><T><A><E><I><S><A><R><E><G><T><G><L><A><G><V><L><A><W><L><Q><A><T><H><R><A><N><D>
May suppress the RNA sensing activity of DDX58 in a GTP-dependent.<BOP>
Q0P5N6
Q9UBI9
HDC_HUMAN
Headcase protein homolog
Homo
<M><P><N><P><K><N><S><K><G><G><R><K><N><K><R><A><N><S><S><G><D><E><Q><E><N><G><A><G><A><L><A><A><A><G><A><A><G><A><A><A><G><G><A><L><A><A><A><A><G><C><G><A><A><A><A><G><A><P><G><A><G><G><A><A><G><A><G><G><A><G><T><G><A><A><N><A><A><A><A><A><G><A><A><A><A><G><D><A><K><N><E><A><P><C><A><T><P><L><I><C><S><F><G><R><P><V><D><L><E><K><D><D><Y><Q><K><V><V><C><N><N><E><H><C><P><C><S><T><W><M><H><L><Q><C><F><Y><E><W><E><S><S><I><L><V><Q><F><N><C><I><G><R><A><R><S><W><N><E><K><Q><C><R><Q><N><M><W><T><K><K><G><Y><D><L><A><F><R><F><C><S><C><R><C><G><Q><G><H><L><K><K><D><T><D><W><Y><Q><V><K><R><M><Q><D><E><K><K><K><K><S><G><S><E><K><N><T><G><R><P><P><G><E><A><A><E><E><A><K><K><C><R><P><P><N><K><P><Q><K><G><P><S><H><D><L><P><R><R><H><S><M><D><R><Q><N><S><Q><E><K><A><V><G><A><A><A><Y><G><A><R><S><P><G><G><S><P><G><Q><S><P><P><T><G><Y><S><I><L><S><P><A><H><F><S><G><P><R><S><S><R><Y><L><G><E><F><L><K><N><A><I><H><L><E><P><H><K><K><A><M><A><G><G><H><V><F><R><N><A><H><F><D><Y><S><P><A><G><L><A><V><H><R><G><G><H><F><D><T><P><V><Q><F><L><R><R><L><D><L><S><E><L><L><T><H><I><P><R><H><K><L><N><T><F><H><V><R><M><E><D><D><A><Q><V><G><Q><G><E><D><L><R><K><F><I><L><A><A><L><S><A><S><H><R><N><V><V><N><C><A><L><C><H><R><A><L><P><V><F><E><Q><F><P><L><V><D><G><T><L><F><L><S><P><S><R><H><D><E><I><E><Y><D><V><P><C><H><L><Q><G><R><L><M><H><L><Y><A><V><C><V><D><C><L><E><G><V><H><K><I><I><C><I><K><C><K><S><R><W><D><G><S><W><H><Q><L><G><T><M><Y><T><Y><D><I><L><A><A><S><P><C><C><Q><A><R><L><N><C><K><H><C><G><K><P><V><I><D><V><R><I><G><M><Q><Y><F><S><E><Y><S><N><V><Q><Q><C><P><H><C><G><N><L><D><Y><H><F><V><K><P><F><S><S><F><K><V><L><E><A><Y>
May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.<BOP>
Q9UBI9
P29084
T2EB_HUMAN
General transcription factor IIE subunit 2
Homo
<M><D><P><S><L><L><R><E><R><E><L><F><K><K><R><A><L><S><T><P><V><V><E><K><R><S><A><S><S><E><S><S><S><S><S><S><K><K><K><K><T><K><V><E><H><G><G><S><S><G><S><K><Q><N><S><D><H><S><N><G><S><F><N><L><K><A><L><S><G><S><S><G><Y><K><F><G><V><L><A><K><I><V><N><Y><M><K><T><R><H><Q><R><G><D><T><H><P><L><T><L><D><E><I><L><D><E><T><Q><H><L><D><I><G><L><K><Q><K><Q><W><L><M><T><E><A><L><V><N><N><P><K><I><E><V><I><D><G><K><Y><A><F><K><P><K><Y><N><V><R><D><K><K><A><L><L><R><L><L><D><Q><H><D><Q><R><G><L><G><G><I><L><L><E><D><I><E><E><A><L><P><N><S><Q><K><A><V><K><A><L><G><D><Q><I><L><F><V><N><R><P><D><K><K><K><I><L><F><F><N><D><K><S><C><Q><F><S><V><D><E><E><F><Q><K><L><W><R><S><V><T><V><D><S><M><D><E><E><K><I><E><E><Y><L><K><R><Q><G><I><S><S><M><Q><E><S><G><P><K><K><V><A><P><I><Q><R><R><K><K><P><A><S><Q><K><K><R><R><F><K><T><H><N><E><H><L><A><G><V><L><K><D><Y><S><D><I><T><S><S><K>
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.<BOP>
P29084
Q7Z402
TMC7_HUMAN
Transmembrane channel-like protein 7
Homo
<M><S><E><S><S><G><S><A><L><Q><P><G><R><P><S><R><Q><P><A><V><H><P><E><N><L><S><L><D><S><S><C><F><S><S><P><P><V><N><F><L><Q><E><L><P><S><Y><R><S><I><A><R><R><R><T><T><V><H><S><R><D><K><Q><S><G><T><L><L><K><P><T><D><S><Y><S><S><Q><L><E><D><R><I><A><E><N><L><S><S><H><S><L><R><N><Y><A><L><N><I><S><E><K><R><R><L><R><D><I><Q><E><T><Q><M><K><Y><L><S><E><W><D><Q><W><K><R><Y><S><S><K><S><W><K><R><F><L><E><K><A><R><E><M><T><T><H><L><E><L><W><R><E><D><I><R><S><I><E><G><K><F><G><T><G><I><Q><S><Y><F><S><F><L><R><F><L><V><L><L><N><L><V><I><F><L><I><I><F><M><L><V><L><L><P><V><L><L><T><K><Y><K><I><T><N><S><S><F><V><L><I><P><F><K><D><M><D><K><Q><C><T><V><Y><P><V><S><S><S><G><L><I><Y><F><Y><S><Y><I><I><D><L><L><S><G><T><G><F><L><E><E><T><S><L><F><Y><G><H><Y><T><I><D><G><V><K><F><Q><N><F><T><Y><D><L><P><L><A><Y><L><L><S><T><I><A><S><L><A><L><S><L><L><W><I><V><K><R><S><V><E><G><F><K><I><N><L><I><R><S><E><E><H><F><Q><S><Y><C><N><K><I><F><A><G><W><D><F><C><I><T><N><R><S><M><A><D><L><K><H><S><S><L><R><Y><E><L><R><A><D><L><E><E><E><R><M><R><Q><K><I><A><E><R><T><S><E><E><T><I><R><I><Y><S><L><R><L><F><L><N><C><I><V><L><A><V><L><G><A><C><F><Y><A><I><Y><V><A><T><V><F><S><Q><E><H><M><K><K><E><I><D><K><M><V><F><G><E><N><L><F><I><L><Y><L><P><S><I><V><I><T><L><A><N><F><I><T><P><M><I><F><A><K><I><I><R><Y><E><D><Y><S><P><G><F><E><I><R><L><T><I><L><R><C><V><F><M><R><L><A><T><I><C><V><L><V><F><T><L><G><S><K><I><T><S><C><D><D><D><T><C><D><L><C><G><Y><N><Q><K><L><Y><P><C><W><E><T><Q><V><G><Q><E><M><Y><K><L><M><I><F><D><F><I><I><I><L><A><V><T><L><F><V><D><F><P><R><K><L><L><V><T><Y><C><S><S><C><K><L><I><Q><C><W><G><Q><Q><E><F><A><I><P><D><N><V><L><G><I><V><Y><G><Q><T><I><C><W><I><G><A><F><F><S><P><L><L><P><A><I><A><T><L><K><F><I><I><I><F><Y><V><K><E><W><S><L><L><Y><T><C><R><P><S><P><R><P><F><R><A><S><N><S><N><F><F><F><L><L><V><L><L><I><G><L><C><L><A><I><I><P><L><T><I><S><I><S><R><I><P><S><S><K><A><C><G><P><F><T><N><F><N><T><T><W><E><V><I><P><K><T><V><S><T><F><P><S><S><L><Q><S><F><I><H><G><V><T><S><E><A><F><A><V><P><F><F><M><I><I><C><L><I><M><F><Y><F><I><A><L><A><G><A><H><K><R><V><V><I><Q><L><R><E><Q><L><S><L><E><S><R><D><K><C><Y><L><I><Q><K><L><T><E><A><Q><R><D><M><R><N>
Probable ion channel.<BOP>
Q7Z402
Q96ID5
IGS21_HUMAN
Immunoglobulin superfamily member 21
Homo
<M><R><T><A><P><S><L><R><R><C><V><C><L><L><L><A><A><I><L><D><L><A><R><G><Y><L><T><V><N><I><E><P><L><P><P><V><V><A><G><D><A><V><T><L><K><C><N><F><K><T><D><G><R><M><R><E><I><V><W><Y><R><V><T><D><G><G><T><I><K><Q><K><I><F><T><F><D><A><M><F><S><T><N><Y><S><H><M><E><N><Y><R><K><R><E><D><L><V><Y><Q><S><T><V><R><L><P><E><V><R><I><S><D><N><G><P><Y><E><C><H><V><G><I><Y><D><R><A><T><R><E><K><V><V><L><A><S><G><N><I><F><L><N><V><M><A><P><P><T><S><I><E><V><V><A><A><D><T><P><A><P><F><S><R><Y><Q><A><Q><N><F><T><L><V><C><I><V><S><G><G><K><P><A><P><M><V><Y><F><K><R><D><G><E><P><I><D><A><V><P><L><S><E><P><P><A><A><S><S><G><P><L><Q><D><S><R><P><F><R><S><L><L><H><R><D><L><D><D><T><K><M><Q><K><S><L><S><L><L><D><A><E><N><R><G><G><R><P><Y><T><E><R><P><S><R><G><L><T><P><D><P><N><I><L><L><Q><P><T><T><E><N><I><P><E><T><V><V><S><R><E><F><P><R><W><V><H><S><A><E><P><T><Y><F><L><R><H><S><R><T><P><S><S><D><G><T><V><E><V><R><A><L><L><T><W><T><L><N><P><Q><I><D><N><E><A><L><F><S><C><E><V><K><H><P><A><L><S><M><P><M><Q><A><E><V><T><L><V><A><P><K><G><P><K><I><V><M><T><P><S><R><A><R><V><G><D><T><V><R><I><L><V><H><G><F><Q><N><E><V><F><P><E><P><M><F><T><W><T><R><V><G><S><R><L><L><D><G><S><A><E><F><D><G><K><E><L><V><L><E><R><V><P><A><E><L><N><G><S><M><Y><R><C><T><A><Q><N><P><L><G><S><T><D><T><H><T><R><L><I><V><F><E><N><P><N><I><P><R><G><T><E><D><S><N><G><S><I><G><P><T><G><A><R><L><T><L><V><L><A><L><T><V><I><L><E><L><T>
Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.<BOP>
Q96ID5
Q53FV1
ORML2_HUMAN
Adoplin-2
Homo
<M><N><V><G><V><A><H><S><E><V><N><P><N><T><R><V><M><N><S><R><G><I><W><L><A><Y><I><I><L><V><G><L><L><H><M><V><L><L><S><I><P><F><F><S><I><P><V><V><W><T><L><T><N><V><I><H><N><L><A><T><Y><V><F><L><H><T><V><K><G><T><P><F><E><T><P><D><Q><G><K><A><R><L><L><T><H><W><E><Q><M><D><Y><G><L><Q><F><T><S><S><R><K><F><L><S><I><S><P><I><V><L><Y><L><L><A><S><F><Y><T><K><Y><D><A><A><H><F><L><I><N><T><A><S><L><L><S><V><L><L><P><K><L><P><Q><F><H><G><V><R><V><F><G><I><N><K><Y>
Negative regulator of sphingolipid synthesis.<BOP>
Q53FV1
Q9H089
LSG1_HUMAN
Large subunit GTPase 1 homolog
Homo
<M><G><R><R><R><A><P><A><G><G><S><L><G><R><A><L><M><R><H><Q><T><Q><R><S><R><S><H><R><H><T><D><S><W><L><H><T><S><E><L><N><D><G><Y><D><W><G><R><L><N><L><Q><S><V><T><E><Q><S><S><L><D><D><F><L><A><T><A><E><L><A><G><T><E><F><V><A><E><K><L><N><I><K><F><V><P><A><E><A><R><T><G><L><L><S><F><E><E><S><Q><R><I><K><K><L><H><E><E><N><K><Q><F><L><C><I><P><R><R><P><N><W><N><Q><N><T><T><P><E><E><L><K><Q><A><E><K><D><N><F><L><E><W><R><R><Q><L><V><R><L><E><E><E><Q><K><L><I><L><T><P><F><E><R><N><L><D><F><W><R><Q><L><W><R><V><I><E><R><S><D><I><V><V><Q><I><V><D><A><R><N><P><L><L><F><R><C><E><D><L><E><C><Y><V><K><E><M><D><A><N><K><E><N><V><I><L><I><N><K><A><D><L><L><T><A><E><Q><R><S><A><W><A><M><Y><F><E><K><E><D><V><K><V><I><F><W><S><A><L><A><G><A><I><P><L><N><G><D><S><E><E><E><A><N><R><D><D><R><Q><S><N><T><T><K><F><G><H><S><S><F><D><Q><A><E><I><S><H><S><E><S><E><H><L><P><A><R><D><S><P><S><L><S><E><N><P><T><T><D><E><D><D><S><E><Y><E><D><C><P><E><E><E><E><D><D><W><Q><T><C><S><E><E><D><G><P><K><E><E><D><C><S><Q><D><W><K><E><S><S><T><A><D><S><E><A><R><S><R><K><T><P><Q><K><R><Q><I><H><N><F><S><H><L><V><S><K><Q><E><L><L><E><L><F><K><E><L><H><T><G><R><K><V><K><D><G><Q><L><T><V><G><L><V><G><Y><P><N><V><G><K><S><S><T><I><N><T><I><M><G><N><K><K><V><S><V><S><A><T><P><G><H><T><K><H><F><Q><T><L><Y><V><E><P><G><L><C><L><C><D><C><P><G><L><V><M><P><S><F><V><S><T><K><A><E><M><T><C><S><G><I><L><P><I><D><Q><M><R><D><H><V><P><P><V><S><L><V><C><Q><N><I><P><R><H><V><L><E><A><T><Y><G><I><N><I><I><T><P><R><E><D><E><D><P><H><R><P><P><T><S><E><E><L><L><T><A><Y><G><Y><M><R><G><F><M><T><A><H><G><Q><P><D><Q><P><R><S><A><R><Y><I><L><K><D><Y><V><S><G><K><L><L><Y><C><H><P><P><P><G><R><D><P><V><T><F><Q><H><Q><H><Q><R><L><L><E><N><K><M><N><S><D><E><I><K><M><Q><L><G><R><N><K><K><A><K><Q><I><E><N><I><V><D><K><T><F><F><H><Q><E><N><V><R><A><L><T><K><G><V><Q><A><V><M><G><Y><K><P><G><S><G><V><V><T><A><S><T><A><S><S><E><N><G><A><G><K><P><W><K><K><H><G><N><R><N><K><K><E><K><S><R><R><L><Y><K><H><L><D><M>
GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable).<BOP>
Q9H089
Q9Y6N5
SQOR_HUMAN
Sulfide quinone oxidoreductase
Homo
<M><V><P><L><V><A><V><V><S><G><P><R><A><Q><L><F><A><C><L><L><R><L><G><T><Q><Q><V><G><P><L><Q><L><H><T><G><A><S><H><A><A><R><N><H><Y><E><V><L><V><L><G><G><G><S><G><G><I><T><M><A><A><R><M><K><R><K><V><G><A><E><N><V><A><I><V><E><P><S><E><R><H><F><Y><Q><P><I><W><T><L><V><G><A><G><A><K><Q><L><S><S><S><G><R><P><T><A><S><V><I><P><S><G><V><E><W><I><K><A><R><V><T><E><L><N><P><D><K><N><C><I><H><T><D><D><D><E><K><I><S><Y><R><Y><L><I><I><A><L><G><I><Q><L><D><Y><E><K><I><K><G><L><P><E><G><F><A><H><P><K><I><G><S><N><Y><S><V><K><T><V><E><K><T><W><K><A><L><Q><D><F><K><E><G><N><A><I><F><T><F><P><N><T><P><V><K><C><A><G><A><P><Q><K><I><M><Y><L><S><E><A><Y><F><R><K><T><G><K><R><S><K><A><N><I><I><F><N><T><S><L><G><A><I><F><G><V><K><K><Y><A><D><A><L><Q><E><I><I><Q><E><R><N><L><T><V><N><Y><K><K><N><L><I><E><V><R><A><D><K><Q><E><A><V><F><E><N><L><D><K><P><G><E><T><Q><V><I><S><Y><E><M><L><H><V><T><P><P><M><S><P><P><D><V><L><K><T><S><P><V><A><D><A><A><G><W><V><D><V><D><K><E><T><L><Q><H><R><R><Y><P><N><V><F><G><I><G><D><C><T><N><L><P><T><S><K><T><A><A><A><V><A><A><Q><S><G><I><L><D><R><T><I><S><V><I><M><K><N><Q><T><P><T><K><K><Y><D><G><Y><T><S><C><P><L><V><T><G><Y><N><R><V><I><L><A><E><F><D><Y><K><A><E><P><L><E><T><F><P><F><D><Q><S><K><E><R><L><S><M><Y><L><M><K><A><D><L><M><P><F><L><Y><W><N><M><M><L><R><G><Y><W><G><G><P><A><F><L><R><K><L><F><H><L><G><M><S>
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) . It is believed the in vivo electron acceptor is glutathione .<BOP>
Q9Y6N5
Q9UNP4
SIAT9_HUMAN
Sialyltransferase 9
Homo
<M><R><T><K><A><A><G><C><A><E><R><R><P><L><Q><P><R><T><E><A><A><A><A><P><A><G><R><A><M><P><S><E><Y><T><Y><V><K><L><R><S><D><C><S><R><P><S><L><Q><W><Y><T><R><A><Q><S><K><M><R><R><P><S><L><L><L><K><D><I><L><K><C><T><L><L><V><F><G><V><W><I><L><Y><I><L><K><L><N><Y><T><T><E><E><C><D><M><K><K><M><H><Y><V><D><P><D><H><V><K><R><A><Q><K><Y><A><Q><Q><V><L><Q><K><E><C><R><P><K><F><A><K><T><S><M><A><L><L><F><E><H><R><Y><S><V><D><L><L><P><F><V><Q><K><A><P><K><D><S><E><A><E><S><K><Y><D><P><P><F><G><F><R><K><F><S><S><K><V><Q><T><L><L><E><L><L><P><E><H><D><L><P><E><H><L><K><A><K><T><C><R><R><C><V><V><I><G><S><G><G><I><L><H><G><L><E><L><G><H><T><L><N><Q><F><D><V><V><I><R><L><N><S><A><P><V><E><G><Y><S><E><H><V><G><N><K><T><T><I><R><M><T><Y><P><E><G><A><P><L><S><D><L><E><Y><Y><S><N><D><L><F><V><A><V><L><F><K><S><V><D><F><N><W><L><Q><A><M><V><K><K><E><T><L><P><F><W><V><R><L><F><F><W><K><Q><V><A><E><K><I><P><L><Q><P><K><H><F><R><I><L><N><P><V><I><I><K><E><T><A><F><D><I><L><Q><Y><S><E><P><Q><S><R><F><W><G><R><D><K><N><V><P><T><I><G><V><I><A><V><V><L><A><T><H><L><C><D><E><V><S><L><A><G><F><G><Y><D><L><N><Q><P><R><T><P><L><H><Y><F><D><S><Q><C><M><A><A><M><N><F><Q><T><M><H><N><V><T><T><E><T><K><F><L><L><K><L><V><K><E><G><V><V><K><D><L><S><G><G><I><D><R><E><F>
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) . Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) .<BOP>
Q9UNP4
O43908
NKG2F_HUMAN
NKG2-F-activating NK receptor
Homo
<M><N><K><Q><R><G><T><Y><S><E><V><S><L><A><Q><D><P><K><R><Q><Q><R><K><L><K><G><N><K><I><S><I><S><G><T><K><Q><E><I><F><Q><V><E><L><N><L><Q><N><A><S><S><D><H><Q><G><N><D><K><T><Y><H><C><K><G><L><L><P><P><P><E><K><L><T><A><E><V><L><G><I><I><C><I><V><L><M><A><T><V><L><K><T><I><V><L><I><P><C><I><G><V><L><E><Q><N><N><F><S><L><N><R><R><M><Q><K><A><R><H><C><G><H><C><P><E><E><W><I><T><Y><S><N><S><C><Y><Y><I><G><K><E><R><R><T><W><E><E><R><V><C><W><P><V><L><R><R><T><L><I><C><F><L>
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.<BOP>
O43908
Q9UBN6
TR10D_HUMAN
TRAIL receptor with a truncated death domain
Homo
<M><G><L><W><G><Q><S><V><P><T><A><S><S><A><R><A><G><R><Y><P><G><A><R><T><A><S><G><T><R><P><W><L><L><D><P><K><I><L><K><F><V><V><F><I><V><A><V><L><L><P><V><R><V><D><S><A><T><I><P><R><Q><D><E><V><P><Q><Q><T><V><A><P><Q><Q><Q><R><R><S><L><K><E><E><E><C><P><A><G><S><H><R><S><E><Y><T><G><A><C><N><P><C><T><E><G><V><D><Y><T><I><A><S><N><N><L><P><S><C><L><L><C><T><V><C><K><S><G><Q><T><N><K><S><S><C><T><T><T><R><D><T><V><C><Q><C><E><K><G><S><F><Q><D><K><N><S><P><E><M><C><R><T><C><R><T><G><C><P><R><G><M><V><K><V><S><N><C><T><P><R><S><D><I><K><C><K><N><E><S><A><A><S><S><T><G><K><T><P><A><A><E><E><T><V><T><T><I><L><G><M><L><A><S><P><Y><H><Y><L><I><I><I><V><V><L><V><I><I><L><A><V><V><V><V><G><F><S><C><R><K><K><F><I><S><Y><L><K><G><I><C><S><G><G><G><G><G><P><E><R><V><H><R><V><L><F><R><R><R><S><C><P><S><R><V><P><G><A><E><D><N><A><R><N><E><T><L><S><N><R><Y><L><Q><P><T><Q><V><S><E><Q><E><I><Q><G><Q><E><L><A><E><L><T><G><V><T><V><E><L><P><E><E><P><Q><R><L><L><E><Q><A><E><A><E><G><C><Q><R><R><R><L><L><V><P><V><N><D><A><D><S><A><D><I><S><T><L><L><D><A><S><A><T><L><E><E><G><H><A><K><E><T><I><Q><D><Q><L><V><G><S><E><K><L><F><Y><E><E><D><E><A><G><S><A><T><S><C><L>
Receptor for the cytotoxic ligand TRAIL . Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis . Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway .<BOP>
Q9UBN6
P61550
ENVT1_HUMAN
Transmembrane protein
Homo
<M><G><P><E><A><W><V><R><P><L><K><T><A><P><K><P><G><E><A><I><R><L><I><L><F><I><Y><L><S><C><F><F><L><P><V><M><S><S><E><P><S><Y><S><F><L><L><T><S><F><T><T><G><R><V><F><A><N><T><T><W><R><A><G><T><S><K><E><V><S><F><A><V><D><L><C><V><L><F><P><E><P><A><R><T><H><E><E><Q><H><N><L><P><V><I><G><A><G><S><V><D><L><A><A><G><F><G><H><S><G><S><Q><T><G><C><G><S><S><K><G><A><E><K><G><L><Q><N><V><D><F><Y><L><C><P><G><N><H><P><D><A><S><C><R><D><T><Y><Q><F><F><C><P><D><W><T><C><V><T><L><A><T><Y><S><G><G><S><T><R><S><S><T><L><S><I><S><R><V><P><H><P><K><L><C><T><R><K><N><C><N><P><L><T><I><T><V><H><D><P><N><A><A><Q><W><Y><Y><G><M><S><W><G><L><R><L><Y><I><P><G><F><D><V><G><T><M><F><T><I><Q><K><K><I><L><V><S><W><S><S><P><K><P><I><G><P><L><T><D><L><G><D><P><I><F><Q><K><H><P><D><K><V><D><L><T><V><P><L><P><F><L><V><P><R><P><Q><L><Q><Q><Q><H><L><Q><P><S><L><M><S><I><L><G><G><V><H><H><L><L><N><L><T><Q><P><K><L><A><Q><D><C><W><L><C><L><K><A><K><P><P><Y><Y><V><G><L><G><V><E><A><T><L><K><R><G><P><L><S><C><H><T><R><P><R><A><L><T><I><G><D><V><S><G><N><A><S><C><L><I><S><T><G><Y><N><L><S><A><S><P><F><Q><A><T><C><N><Q><S><L><L><T><S><I><S><T><S><V><S><Y><Q><A><P><N><N><T><W><L><A><C><T><S><G><L><T><R><C><I><N><G><T><E><P><G><P><L><L><C><V><L><V><H><V><L><P><Q><V><Y><V><Y><S><G><P><E><G><R><Q><L><I><A><P><P><E><L><H><P><R><L><H><Q><A><V><P><L><L><V><P><L><L><A><G><L><S><I><A><G><S><A><A><I><G><T><A><A><L><V><Q><G><E><T><G><L><I><S><L><S><Q><Q><V><D><A><D><F><S><N><L><Q><S><A><I><D><I><L><H><S><Q><V><E><S><L><A><E><V><V><L><Q><N><C><R><C><L><D><L><L><F><L><S><Q><G><G><L><C><A><A><L><G><E><S><C><C><F><Y><A><N><Q><S><G><V><I><K><G><T><V><K><K><V><R><E><N><L><D><R><H><Q><Q><E><R><E><N><N><I><P><W><Y><Q><S><M><F><N><W><N><P><W><L><T><T><L><I><T><G><L><A><G><P><L><L><I><L><L><L><S><L><I><F><G><P><C><I><L><N><S><F><L><N><F><I><K><Q><R><I><A><S><V><K><L><T><Y><L><K><T><Q><Y><D><T><L><V><N><N>
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.<BOP>
P61550
Q7LDI9
GAK6_HUMAN
HERV-K_7p22.1 provirus ancestral Gag polyprotein
Homo
<M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><V><S><V><S><D><A><P><G><S><C><I><I><D><C><N><E><N><T><R><K><K><S><Q><K><E><T><E><G><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><G><P><E><L><V><G><P><S><E><S><K><P><R><G><T><S><P><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><K><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><R><P><P><P><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><Q><G><S><K><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><K><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><D><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><A><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><I><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><R><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><Q><G><F><Q><G><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><P><P><Q><A><A><V><Q><Q>
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP>
Q7LDI9
Q567U6
CCD93_HUMAN
Coiled-coil domain-containing protein 93
Homo
<M><G><L><P><R><G><P><E><G><Q><G><L><P><E><V><E><T><R><E><D><E><E><Q><N><V><K><L><T><E><I><L><E><L><L><V><A><A><G><Y><F><R><A><R><I><K><G><L><S><P><F><D><K><V><V><G><G><M><T><W><C><I><T><T><C><N><F><D><V><D><V><D><L><L><F><Q><E><N><S><T><I><G><Q><K><I><A><L><S><E><K><I><V><S><V><L><P><R><M><K><C><P><H><Q><L><E><P><H><Q><I><Q><G><M><D><F><I><H><I><F><P><V><V><Q><W><L><V><K><R><A><I><E><T><K><E><E><M><G><D><Y><I><R><S><Y><S><V><S><Q><F><Q><K><T><Y><S><L><P><E><D><D><D><F><I><K><R><K><E><K><A><I><K><T><V><V><D><L><S><E><V><Y><K><P><R><R><K><Y><K><R><H><Q><G><A><E><E><L><L><D><E><E><S><R><I><H><A><T><L><L><E><Y><G><R><R><Y><G><F><S><R><Q><S><K><M><E><K><A><E><D><K><K><T><A><L><P><A><G><L><S><A><T><E><K><A><D><A><H><E><E><D><E><L><R><A><A><E><E><Q><R><I><Q><S><L><M><T><K><M><T><A><M><A><N><E><E><S><R><L><T><A><S><S><V><G><Q><I><V><G><L><C><S><A><E><I><K><Q><I><V><S><E><Y><A><E><K><Q><S><E><L><S><A><E><E><S><P><E><K><L><G><T><S><Q><L><H><R><R><K><V><I><S><L><N><K><Q><I><A><Q><K><T><K><H><L><E><E><L><R><A><S><H><T><S><L><Q><A><R><Y><N><E><A><K><K><T><L><T><E><L><K><T><Y><S><E><K><L><D><K><E><Q><A><A><L><E><K><I><E><S><K><A><D><P><S><I><L><Q><N><L><R><A><L><V><A><M><N><E><N><L><K><S><Q><E><Q><E><F><K><A><H><C><R><E><E><M><T><R><L><Q><Q><E><I><E><N><L><K><A><E><R><A><P><R><G><D><E><K><T><L><S><S><G><E><P><P><G><T><L><T><S><A><M><T><H><D><E><D><L><D><R><R><Y><N><M><E><K><E><K><L><Y><K><I><R><L><L><Q><A><R><R><N><R><E><I><A><I><L><H><R><K><I><D><E><V><P><S><R><A><E><L><I><Q><Y><Q><K><R><F><I><E><L><Y><R><Q><I><S><A><V><H><K><E><T><K><Q><F><F><T><L><Y><N><T><L><D><D><K><K><V><Y><L><E><K><E><I><S><L><L><N><S><I><H><E><N><F><S><Q><A><M><A><S><P><A><A><R><D><Q><F><L><R><Q><M><E><Q><I><V><E><G><I><K><Q><S><R><M><K><M><E><K><K><K><Q><E><N><K><M><R><R><D><Q><L><N><D><Q><Y><L><E><L><L><E><K><Q><R><L><Y><F><K><T><V><K><E><F><K><E><E><G><R><K><N><E><M><L><L><S><K><V><K><A><K><A><S>
(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.<BOP>
Q567U6
Q8WVB3
HEXD_HUMAN
N-acetyl-beta-galactosaminidase
Homo
<M><S><G><S><T><P><F><Q><M><R><L><V><H><L><D><L><K><G><A><P><P><K><V><S><Y><L><S><E><I><F><P><L><F><R><A><L><G><A><N><G><L><L><I><E><Y><E><D><M><F><P><Y><E><G><P><L><R><L><L><R><A><K><Y><A><Y><S><P><S><E><I><K><E><I><L><H><L><A><G><L><N><E><L><E><V><I><P><L><V><Q><T><F><G><H><M><E><F><V><L><K><H><T><A><F><A><H><L><R><E><V><G><S><F><P><C><T><L><N><P><H><E><A><E><S><L><A><L><V><G><A><M><I><D><Q><V><L><E><L><H><P><G><A><Q><R><L><H><I><G><C><D><E><V><Y><Y><L><G><E><G><E><A><S><R><R><W><L><Q><Q><E><Q><N><S><T><G><K><L><C><L><S><H><M><R><A><V><A><S><G><V><K><A><R><R><P><S><V><T><P><L><V><W><D><D><M><L><R><D><L><P><E><D><Q><L><A><A><S><G><V><P><Q><L><V><E><P><V><L><W><D><Y><T><A><D><L><D><V><H><G><K><V><L><L><M><Q><K><Y><R><R><C><G><F><P><Q><L><W><A><A><S><A><F><K><G><A><T><G><P><S><Q><A><V><P><P><V><E><H><H><L><R><N><H><V><Q><W><L><Q><V><A><G><S><G><P><T><D><S><L><Q><G><I><I><L><T><G><W><Q><R><Y><D><H><Y><S><V><L><C><E><L><L><P><A><G><V><P><S><L><A><A><C><L><Q><L><L><L><R><G><G><F><D><E><D><V><K><A><K><V><E><N><L><L><G><I><S><S><L><E><K><T><D><P><V><R><E><G><A><G><S><F><P><G><S><N><I><L><A><L><V><T><Q><V><S><L><H><L><R><S><S><V><D><A><L><L><E><G><N><R><Y><V><T><G><W><F><S><P><Y><H><R><Q><R><K><L><I><H><P><V><M><V><Q><H><I><Q><P><A><A><L><S><L><L><A><Q><W><S><T><L><V><Q><E><L><E><A><A><L><Q><L><A><F><Y><P><D><A><V><E><E><W><L><E><E><N><V><H><P><S><L><Q><R><L><Q><A><L><L><Q><D><L><S><E><V><S><A><P><P><L><P><P><T><S><P><G><R><D><V><A><Q><D><P>
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates .<BOP>
Q8WVB3
Q15418
KS6A1_HUMAN
Ribosomal S6 kinase 1
Homo
<M><P><L><A><Q><L><K><E><P><W><P><L><M><E><L><V><P><L><D><P><E><N><G><Q><T><S><G><E><E><A><G><L><Q><P><S><K><D><E><G><V><L><K><E><I><S><I><T><H><H><V><K><A><G><S><E><K><A><D><P><S><H><F><E><L><L><K><V><L><G><Q><G><S><F><G><K><V><F><L><V><R><K><V><T><R><P><D><S><G><H><L><Y><A><M><K><V><L><K><K><A><T><L><K><V><R><D><R><V><R><T><K><M><E><R><D><I><L><A><D><V><N><H><P><F><V><V><K><L><H><Y><A><F><Q><T><E><G><K><L><Y><L><I><L><D><F><L><R><G><G><D><L><F><T><R><L><S><K><E><V><M><F><T><E><E><D><V><K><F><Y><L><A><E><L><A><L><G><L><D><H><L><H><S><L><G><I><I><Y><R><D><L><K><P><E><N><I><L><L><D><E><E><G><H><I><K><L><T><D><F><G><L><S><K><E><A><I><D><H><E><K><K><A><Y><S><F><C><G><T><V><E><Y><M><A><P><E><V><V><N><R><Q><G><H><S><H><S><A><D><W><W><S><Y><G><V><L><M><F><E><M><L><T><G><S><L><P><F><Q><G><K><D><R><K><E><T><M><T><L><I><L><K><A><K><L><G><M><P><Q><F><L><S><T><E><A><Q><S><L><L><R><A><L><F><K><R><N><P><A><N><R><L><G><S><G><P><D><G><A><E><E><I><K><R><H><V><F><Y><S><T><I><D><W><N><K><L><Y><R><R><E><I><K><P><P><F><K><P><A><V><A><Q><P><D><D><T><F><Y><F><D><T><E><F><T><S><R><T><P><K><D><S><P><G><I><P><P><S><A><G><A><H><Q><L><F><R><G><F><S><F><V><A><T><G><L><M><E><D><D><G><K><P><R><A><P><Q><A><P><L><H><S><V><V><Q><Q><L><H><G><K><N><L><V><F><S><D><G><Y><V><V><K><E><T><I><G><V><G><S><Y><S><E><C><K><R><C><V><H><K><A><T><N><M><E><Y><A><V><K><V><I><D><K><S><K><R><D><P><S><E><E><I><E><I><L><L><R><Y><G><Q><H><P><N><I><I><T><L><K><D><V><Y><D><D><G><K><H><V><Y><L><V><T><E><L><M><R><G><G><E><L><L><D><K><I><L><R><Q><K><F><F><S><E><R><E><A><S><F><V><L><H><T><I><G><K><T><V><E><Y><L><H><S><Q><G><V><V><H><R><D><L><K><P><S><N><I><L><Y><V><D><E><S><G><N><P><E><C><L><R><I><C><D><F><G><F><A><K><Q><L><R><A><E><N><G><L><L><M><T><P><C><Y><T><A><N><F><V><A><P><E><V><L><K><R><Q><G><Y><D><E><G><C><D><I><W><S><L><G><I><L><L><Y><T><M><L><A><G><Y><T><P><F><A><N><G><P><S><D><T><P><E><E><I><L><T><R><I><G><S><G><K><F><T><L><S><G><G><N><W><N><T><V><S><E><T><A><K><D><L><V><S><K><M><L><H><V><D><P><H><Q><R><L><T><A><K><Q><V><L><Q><H><P><W><V><T><Q><K><D><K><L><P><Q><S><Q><L><S><H><Q><D><L><Q><L><V><K><G><A><M><A><A><T><Y><S><A><L><N><S><S><K><P><T><P><Q><L><K><P><I><E><S><S><I><L><A><Q><R><R><V><R><K><L><P><S><T><T><L>
(Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated.<BOP>
Q15418
Q9GZP4
PITH1_HUMAN
PITH domain-containing protein 1
Homo
<M><S><H><G><H><S><H><G><G><G><G><C><R><C><A><A><E><R><E><E><P><P><E><Q><R><G><L><A><Y><G><L><Y><L><R><I><D><L><E><R><L><Q><C><L><N><E><S><R><E><G><S><G><R><G><V><F><K><P><W><E><E><R><T><D><R><S><K><F><V><E><S><D><A><D><E><E><L><L><F><N><I><P><F><T><G><N><V><K><L><K><G><I><I><I><M><G><E><D><D><D><S><H><P><S><E><M><R><L><Y><K><N><I><P><Q><M><S><F><D><D><T><E><R><E><P><D><Q><T><F><S><L><N><R><D><L><T><G><E><L><E><Y><A><T><K><I><S><R><F><S><N><V><Y><H><L><S><I><H><I><S><K><N><F><G><A><D><T><T><K><V><F><Y><I><G><L><R><G><E><W><T><E><L><R><R><H><E><V><T><I><C><N><Y><E><A><S><A><N><P><A><D><H><R><V><H><Q><V><T><P><Q><T><H><F><I><S>
Promotes megakaryocyte differentiation by up-regulating RUNX1 expression . Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene .<BOP>
Q9GZP4
Q14449
GRB14_HUMAN
GRB14 adapter protein
Homo
<M><T><T><S><L><Q><D><G><Q><S><A><A><S><R><A><A><A><R><D><S><P><L><A><A><Q><V><C><G><A><A><Q><G><R><G><D><A><H><D><L><A><P><A><P><W><L><H><A><R><A><L><L><P><L><P><D><G><T><R><G><C><A><A><D><R><R><K><K><K><D><L><D><V><P><E><M><P><S><I><P><N><P><F><P><E><L><C><C><S><P><F><T><S><V><L><S><A><D><L><F><P><K><A><N><S><R><K><K><Q><V><I><K><V><Y><S><E><D><E><T><S><R><A><L><D><V><P><S><D><I><T><A><R><D><V><C><Q><L><L><I><L><K><N><H><Y><I><D><D><H><S><W><T><L><F><E><H><L><P><H><I><G><V><E><R><T><I><E><D><H><E><L><V><I><E><V><L><S><N><W><G><I><E><E><E><N><K><L><Y><F><R><K><N><Y><A><K><Y><E><F><F><K><N><P><M><Y><F><F><P><E><H><M><V><S><F><A><T><E><T><N><G><E><I><S><P><T><Q><I><L><Q><M><F><L><S><S><S><T><Y><P><E><I><H><G><F><L><H><A><K><E><Q><G><K><K><S><W><K><K><I><Y><F><F><L><R><R><S><G><L><Y><F><S><T><K><G><T><S><K><E><P><R><H><L><Q><F><F><S><E><F><G><N><S><D><I><Y><V><S><L><A><G><K><K><K><H><G><A><P><T><N><Y><G><F><C><F><K><P><N><K><A><G><G><P><R><D><L><K><M><L><C><A><E><E><E><Q><S><R><T><C><W><V><T><A><I><R><L><L><K><Y><G><M><Q><L><Y><Q><N><Y><M><H><P><Y><Q><G><R><S><G><C><S><S><Q><S><I><S><P><M><R><S><I><S><E><N><S><L><V><A><M><D><F><S><G><Q><K><S><R><V><I><E><N><P><T><E><A><L><S><V><A><V><E><E><G><L><A><W><R><K><K><G><C><L><R><L><G><T><H><G><S><P><T><A><S><S><Q><S><S><A><T><N><M><A><I><H><R><S><Q><P><W><F><H><H><K><I><S><R><D><E><A><Q><R><L><I><I><Q><Q><G><L><V><D><G><V><F><L><V><R><D><S><Q><S><N><P><K><T><F><V><L><S><M><S><H><G><Q><K><I><K><H><F><Q><I><I><P><V><E><D><D><G><E><M><F><H><T><L><D><D><G><H><T><R><F><T><D><L><I><Q><L><V><E><F><Y><Q><L><N><K><G><V><L><P><C><K><L><K><H><Y><C><A><R><I><A><L>
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<BOP>
Q14449
P49903
SPS1_HUMAN
Selenophosphate synthase 1
Homo
<M><S><T><R><E><S><F><N><P><E><S><Y><E><L><D><K><S><F><R><L><T><R><F><T><E><L><K><G><T><G><C><K><V><P><Q><D><V><L><Q><K><L><L><E><S><L><Q><E><N><H><F><Q><E><D><E><Q><F><L><G><A><V><M><P><R><L><G><I><G><M><D><T><C><V><I><P><L><R><H><G><G><L><S><L><V><Q><T><T><D><Y><I><Y><P><I><V><D><D><P><Y><M><M><G><R><I><A><C><A><N><V><L><S><D><L><Y><A><M><G><V><T><E><C><D><N><M><L><M><L><L><G><V><S><N><K><M><T><D><R><E><R><D><K><V><M><P><L><I><I><Q><G><F><K><D><A><A><E><E><A><G><T><S><V><T><G><G><Q><T><V><L><N><P><W><I><V><L><G><G><V><A><T><T><V><C><Q><P><N><E><F><I><M><P><D><N><A><V><P><G><D><V><L><V><L><T><K><P><L><G><T><Q><V><A><V><A><V><H><Q><W><L><D><I><P><E><K><W><N><K><I><K><L><V><V><T><Q><E><D><V><E><L><A><Y><Q><E><A><M><M><N><M><A><R><L><N><R><T><A><A><G><L><M><H><T><F><N><A><H><A><A><T><D><I><T><G><F><G><I><L><G><H><A><Q><N><L><A><K><Q><Q><R><N><E><V><S><F><V><I><H><N><L><P><V><L><A><K><M><A><A><V><S><K><A><C><G><N><M><F><G><L><M><H><G><T><C><P><E><T><S><G><G><L><L><I><C><L><P><R><E><Q><A><A><R><F><C><A><E><I><K><S><P><K><Y><G><E><G><H><Q><A><W><I><I><G><I><V><E><K><G><N><R><T><A><R><I><I><D><K><P><R><I><I><E><V><A><P><Q><V><A><T><Q><N><V><N><P><T><P><G><A><T><S>
Synthesizes selenophosphate from selenide and ATP.<BOP>
P49903
A6NNA5
DRGX_HUMAN
Paired-related homeobox protein-like 1
Homo
<M><F><Y><F><H><C><P><P><Q><L><E><G><T><A><T><F><G><N><H><S><S><G><D><F><D><D><G><F><L><R><R><K><Q><R><R><N><R><T><T><F><T><L><Q><Q><L><E><A><L><E><A><V><F><A><Q><T><H><Y><P><D><V><F><T><R><E><E><L><A><M><K><I><N><L><T><E><A><R><V><Q><V><W><F><Q><N><R><R><A><K><W><R><K><T><E><R><G><A><S><D><Q><E><P><G><A><K><E><P><M><A><E><V><T><P><P><P><V><R><N><I><N><S><P><P><P><G><D><Q><A><R><S><K><K><E><A><L><E><A><Q><Q><S><L><G><R><T><V><G><P><A><G><P><F><F><P><S><C><L><P><G><T><L><L><N><T><A><T><Y><A><Q><A><L><S><H><V><A><S><L><K><G><G><P><L><C><S><C><C><V><P><D><P><M><G><L><S><F><L><P><T><Y><G><C><Q><S><N><R><T><A><S><V><A><T><L><R><M><K><A><R><E><H><S><E><A><V><L><Q><S><A><N><L><L><P><S><T><S><S><S><P><G><P><V><A><K><P><A><P><P><D><G><S><Q><E><K><T><S><P><T><K><E><Q><S><E><A><E><K><S><V>
Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.<BOP>
A6NNA5
Q9H221
ABCG8_HUMAN
Sterolin-2
Homo
<M><A><G><K><A><A><E><E><R><G><L><P><K><G><A><T><P><Q><D><T><S><G><L><Q><D><R><L><F><S><S><E><S><D><N><S><L><Y><F><T><Y><S><G><Q><P><N><T><L><E><V><R><D><L><N><Y><Q><V><D><L><A><S><Q><V><P><W><F><E><Q><L><A><Q><F><K><M><P><W><T><S><P><S><C><Q><N><S><C><E><L><G><I><Q><N><L><S><F><K><V><R><S><G><Q><M><L><A><I><I><G><S><S><G><C><G><R><A><S><L><L><D><V><I><T><G><R><G><H><G><G><K><I><K><S><G><Q><I><W><I><N><G><Q><P><S><S><P><Q><L><V><R><K><C><V><A><H><V><R><Q><H><N><Q><L><L><P><N><L><T><V><R><E><T><L><A><F><I><A><Q><M><R><L><P><R><T><F><S><Q><A><Q><R><D><K><R><V><E><D><V><I><A><E><L><R><L><R><Q><C><A><D><T><R><V><G><N><M><Y><V><R><G><L><S><G><G><E><R><R><R><V><S><I><G><V><Q><L><L><W><N><P><G><I><L><I><L><D><E><P><T><S><G><L><D><S><F><T><A><H><N><L><V><K><T><L><S><R><L><A><K><G><N><R><L><V><L><I><S><L><H><Q><P><R><S><D><I><F><R><L><F><D><L><V><L><L><M><T><S><G><T><P><I><Y><L><G><A><A><Q><H><M><V><Q><Y><F><T><A><I><G><Y><P><C><P><R><Y><S><N><P><A><D><F><Y><V><D><L><T><S><I><D><R><R><S><R><E><Q><E><L><A><T><R><E><K><A><Q><S><L><A><A><L><F><L><E><K><V><R><D><L><D><D><F><L><W><K><A><E><T><K><D><L><D><E><D><T><C><V><E><S><S><V><T><P><L><D><T><N><C><L><P><S><P><T><K><M><P><G><A><V><Q><Q><F><T><T><L><I><R><R><Q><I><S><N><D><F><R><D><L><P><T><L><L><I><H><G><A><E><A><C><L><M><S><M><T><I><G><F><L><Y><F><G><H><G><S><I><Q><L><S><F><M><D><T><A><A><L><L><F><M><I><G><A><L><I><P><F><N><V><I><L><D><V><I><S><K><C><Y><S><E><R><A><M><L><Y><Y><E><L><E><D><G><L><Y><T><T><G><P><Y><F><F><A><K><I><L><G><E><L><P><E><H><C><A><Y><I><I><I><Y><G><M><P><T><Y><W><L><A><N><L><R><P><G><L><Q><P><F><L><L><H><F><L><L><V><W><L><V><V><F><C><C><R><I><M><A><L><A><A><A><A><L><L><P><T><F><H><M><A><S><F><F><S><N><A><L><Y><N><S><F><Y><L><A><G><G><F><M><I><N><L><S><S><L><W><T><V><P><A><W><I><S><K><V><S><F><L><R><W><C><F><E><G><L><M><K><I><Q><F><S><R><R><T><Y><K><M><P><L><G><N><L><T><I><A><V><S><G><D><K><I><L><S><V><M><E><L><D><S><Y><P><L><Y><A><I><Y><L><I><V><I><G><L><S><G><G><F><M><V><L><Y><Y><V><S><L><R><F><I><K><Q><K><P><S><Q><D><W>
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile . Required for normal sterol homeostasis . The heterodimer with ABCG5 has ATPase activity .<BOP>
Q9H221
Q86UC2
RSPH3_HUMAN
Radial spoke head-like protein 2
Homo
<M><T><V><K><P><A><K><A><A><S><L><A><R><N><L><A><K><R><R><R><T><Y><L><G><G><A><A><G><R><S><Q><E><P><E><V><P><C><A><A><V><L><P><G><K><P><G><D><R><N><C><P><E><F><P><P><P><D><R><T><L><G><C><W><A><T><D><A><A><P><A><A><G><L><C><G><A><G><S><E><P><S><I><A><P><T><S><C><A><G><N><L><P><S><R><P><P><P><L><L><S><P><L><L><A><S><R><N><P><C><P><W><H><Y><L><H><L><S><G><S><H><N><T><L><A><P><T><C><F><K><A><K><L><H><R><K><R><G><S><Q><P><P><D><M><A><S><A><L><T><D><R><T><S><R><A><P><S><T><Y><T><Y><T><S><R><P><R><A><L><P><C><Q><R><S><R><Y><R><D><S><L><T><Q><P><D><E><E><P><M><H><Y><G><N><I><M><Y><D><R><R><V><I><R><G><N><T><Y><A><L><Q><T><G><P><L><L><G><R><P><D><S><L><E><L><Q><R><Q><R><E><A><R><K><R><A><L><A><R><K><Q><A><Q><E><Q><L><R><P><Q><T><P><E><P><V><E><G><R><K><H><V><D><V><Q><T><E><L><Y><L><E><E><I><A><D><R><I><I><E><V><D><M><E><C><Q><T><D><A><F><L><D><R><P><P><T><P><L><F><I><P><A><K><T><G><K><D><V><A><T><Q><I><L><E><G><E><L><F><D><F><D><L><E><V><K><P><V><L><E><V><L><V><G><K><T><I><E><Q><S><L><L><E><V><M><E><E><E><E><L><A><N><L><R><A><S><Q><R><E><Y><E><E><L><R><N><S><E><R><A><E><V><Q><R><L><E><E><Q><E><R><R><H><R><E><E><K><E><R><R><K><K><Q><Q><W><E><I><M><H><K><H><N><E><T><S><Q><K><I><A><A><R><A><F><A><Q><R><Y><L><A><D><L><L><P><S><V><F><G><S><L><R><D><S><G><Y><F><Y><D><P><I><E><R><D><I><E><I><G><F><L><P><W><L><M><N><E><V><E><K><T><M><E><Y><S><M><V><G><R><T><V><L><D><M><L><I><R><E><V><V><E><K><R><L><C><M><Y><E><H><G><E><D><T><H><Q><S><P><E><P><E><D><E><P><G><G><P><G><A><M><T><E><S><L><E><A><S><E><F><L><E><Q><S><M><S><Q><T><R><E><L><L><L><D><G><G><Y><L><Q><R><T><T><Y><D><R><R><S><S><Q><E><R><K><F><M><E><E><R><E><L><L><G><Q><D><E><E><T><A><M><R><K><S><L><G><E><E><E><L><S>
Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.<BOP>
Q86UC2
Q9UPY5
XCT_HUMAN
xCT
Homo
<M><V><R><K><P><V><V><S><T><I><S><K><G><G><Y><L><Q><G><N><V><N><G><R><L><P><S><L><G><N><K><E><P><P><G><Q><E><K><V><Q><L><K><R><K><V><T><L><L><R><G><V><S><I><I><I><G><T><I><I><G><A><G><I><F><I><S><P><K><G><V><L><Q><N><T><G><S><V><G><M><S><L><T><I><W><T><V><C><G><V><L><S><L><F><G><A><L><S><Y><A><E><L><G><T><T><I><K><K><S><G><G><H><Y><T><Y><I><L><E><V><F><G><P><L><P><A><F><V><R><V><W><V><E><L><L><I><I><R><P><A><A><T><A><V><I><S><L><A><F><G><R><Y><I><L><E><P><F><F><I><Q><C><E><I><P><E><L><A><I><K><L><I><T><A><V><G><I><T><V><V><M><V><L><N><S><M><S><V><S><W><S><A><R><I><Q><I><F><L><T><F><C><K><L><T><A><I><L><I><I><I><V><P><G><V><M><Q><L><I><K><G><Q><T><Q><N><F><K><D><A><F><S><G><R><D><S><S><I><T><R><L><P><L><A><F><Y><Y><G><M><Y><A><Y><A><G><W><F><Y><L><N><F><V><T><E><E><V><E><N><P><E><K><T><I><P><L><A><I><C><I><S><M><A><I><V><T><I><G><Y><V><L><T><N><V><A><Y><F><T><T><I><N><A><E><E><L><L><L><S><N><A><V><A><V><T><F><S><E><R><L><L><G><N><F><S><L><A><V><P><I><F><V><A><L><S><C><F><G><S><M><N><G><G><V><F><A><V><S><R><L><F><Y><V><A><S><R><E><G><H><L><P><E><I><L><S><M><I><H><V><R><K><H><T><P><L><P><A><V><I><V><L><H><P><L><T><M><I><M><L><F><S><G><D><L><D><S><L><L><N><F><L><S><F><A><R><W><L><F><I><G><L><A><V><A><G><L><I><Y><L><R><Y><K><C><P><D><M><H><R><P><F><K><V><P><L><F><I><P><A><L><F><S><F><T><C><L><F><M><V><A><L><S><L><Y><S><D><P><F><S><T><G><I><G><F><V><I><T><L><T><G><V><P><A><Y><Y><L><F><I><I><W><D><K><K><P><R><W><F><R><I><M><S><E><K><I><T><R><T><L><Q><I><I><L><E><V><V><P><E><E><D><K><L>
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.<BOP>
Q9UPY5
Q9Y5K1
SPO11_HUMAN
Cancer/testis antigen 35
Homo
<M><A><F><A><P><M><G><P><E><A><S><F><F><D><V><L><D><R><H><R><E><S><L><L><A><A><L><R><R><G><G><R><E><P><P><T><G><G><S><R><L><A><S><S><S><E><V><L><A><S><I><E><N><I><I><Q><D><I><I><T><S><L><A><R><N><E><A><P><A><F><T><I><D><N><R><S><S><W><E><N><I><K><F><E><D><S><V><G><L><Q><M><V><S><H><C><T><T><R><K><I><K><S><D><S><P><K><S><A><Q><K><F><S><L><I><L><K><I><L><S><M><I><Y><K><L><V><Q><S><N><T><Y><A><T><K><R><D><I><Y><Y><T><D><S><Q><L><F><G><N><Q><T><V><V><D><N><I><I><N><D><I><S><C><M><L><K><V><S><R><R><S><L><H><I><L><S><T><S><K><G><L><I><A><G><N><L><R><Y><I><E><E><D><G><T><K><V><N><C><T><C><G><A><T><A><V><A><V><P><S><N><I><Q><G><I><R><N><L><V><T><D><A><K><F><V><L><I><V><E><K><D><A><T><F><Q><R><L><L><D><D><N><F><C><N><K><L><S><P><C><I><M><I><T><G><K><G><V><P><D><L><N><T><R><L><L><V><K><K><L><W><D><T><F><H><V><P><V><F><T><L><V><D><A><D><P><H><G><I><E><I><M><C><I><Y><K><Y><G><S><M><S><M><S><F><E><A><H><H><L><T><V><P><A><I><R><W><L><G><L><L><P><S><D><L><K><R><L><N><V><P><K><D><S><L><I><P><L><T><K><R><D><Q><M><K><L><D><S><I><L><R><R><P><Y><V><T><C><Q><P><F><W><R><K><E><M><E><I><M><A><D><S><K><M><K><A><E><I><Q><A><L><T><F><L><S><S><D><Y><L><S><R><V><Y><L><P><N><K><L><K><F><G><G><W><I>
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.<BOP>
Q9Y5K1