accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q9NYD6
HXC10_HUMAN
Homeobox protein Hox-3I
Homo
<M><T><C><P><R><N><V><T><P><N><S><Y><A><E><P><L><A><A><P><G><G><G><E><R><Y><S><R><S><A><G><M><Y><M><Q><S><G><S><D><F><N><C><G><V><M><R><G><C><G><L><A><P><S><L><S><K><R><D><E><G><S><S><P><S><L><A><L><N><T><Y><P><S><Y><L><S><Q><L><D><S><W><G><D><P><K><A><A><Y><R><L><E><Q><P><V><G><R><P><L><S><S><C><S><Y><P><P><S><V><K><E><E><N><V><C><C><M><Y><S><A><E><K><R><A><K><S><G><P><E><A><A><L><Y><S><H><P><L><P><E><S><C><L><G><E><H><E><V><P><V><P><S><Y><Y><R><A><S><P><S><Y><S><A><L><D><K><T><P><H><C><S><G><A><N><D><F><E><A><P><F><E><Q><R><A><S><L><N><P><R><A><E><H><L><E><S><P><Q><L><G><G><K><V><S><F><P><E><T><P><K><S><D><S><Q><T><P><S><P><N><E><I><K><T><E><Q><S><L><A><G><P><K><G><S><P><S><E><S><E><K><E><R><A><K><A><A><D><S><S><P><D><T><S><D><N><E><A><K><E><E><I><K><A><E><N><T><T><G><N><W><L><T><A><K><S><G><R><K><K><R><C><P><Y><T><K><H><Q><T><L><E><L><E><K><E><F><L><F><N><M><Y><L><T><R><E><R><R><L><E><I><S><K><T><I><N><L><T><D><R><Q><V><K><I><W><F><Q><N><R><R><M><K><L><K><K><M><N><R><E><N><R><I><R><E><L><T><S><N><F><N><F><T>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
Q9NYD6
Q9H9A5
CNO10_HUMAN
CCR4-NOT transcription complex subunit 10
Homo
<M><A><A><D><K><P><A><D><Q><G><A><E><K><H><E><G><T><G><Q><S><S><G><I><T><D><Q><E><K><E><L><S><T><N><A><F><Q><A><F><T><S><G><N><Y><D><A><C><L><Q><H><L><A><C><L><Q><D><I><N><K><D><D><Y><K><I><I><L><N><T><A><V><A><E><F><F><K><S><N><Q><T><T><T><D><N><L><R><Q><T><L><N><Q><L><K><N><Q><V><H><S><A><V><E><E><M><D><G><L><D><D><V><E><N><S><M><L><Y><Y><N><Q><A><V><I><L><Y><H><L><R><Q><Y><T><E><A><I><S><V><G><E><K><L><Y><Q><F><I><E><P><F><E><E><K><F><A><Q><A><V><C><F><L><L><V><D><L><Y><I><L><T><Y><Q><A><E><K><A><L><H><L><L><A><V><L><E><K><M><I><S><Q><G><N><N><N><K><N><G><K><N><E><T><G><N><N><N><N><K><D><G><S><N><H><K><A><E><S><G><A><L><I><E><A><A><K><S><K><I><H><Q><Y><K><V><R><A><Y><I><Q><M><K><S><L><K><A><C><K><R><E><I><K><S><V><M><N><T><A><G><N><S><A><P><S><L><F><L><K><S><N><F><E><Y><L><R><G><N><Y><R><K><A><V><K><L><L><N><S><S><N><I><A><E><H><P><G><F><M><K><T><G><E><C><L><R><C><M><F><W><N><N><L><G><C><I><H><F><A><M><S><K><H><N><L><G><I><F><Y><F><K><K><A><L><Q><E><N><D><N><V><C><A><Q><L><S><A><G><S><T><D><P><G><K><K><F><S><G><R><P><M><C><T><L><L><T><N><K><R><Y><E><L><L><Y><N><C><G><I><Q><L><L><H><I><G><R><P><L><A><A><F><E><C><L><I><E><A><V><Q><V><Y><H><A><N><P><R><L><W><L><R><L><A><E><C><C><I><A><A><N><K><G><T><S><E><Q><E><T><K><G><L><P><S><K><K><G><I><V><Q><S><I><V><G><Q><G><Y><H><R><K><I><V><L><A><S><Q><S><I><Q><N><T><V><Y><N><D><G><Q><S><S><A><I><P><V><A><S><M><E><F><A><A><I><C><L><R><N><A><L><L><L><L><P><E><E><Q><Q><D><P><K><Q><E><N><G><A><K><N><S><N><Q><L><G><G><N><T><E><S><S><E><S><S><E><T><C><S><S><K><S><H><D><G><D><K><F><I><P><A><P><P><S><S><P><L><R><K><Q><E><L><E><N><L><K><C><S><I><L><A><C><S><A><Y><V><A><L><A><L><G><D><N><L><M><A><L><N><H><A><D><K><L><L><Q><Q><P><K><L><S><G><S><L><K><F><L><G><H><L><Y><A><A><E><A><L><I><S><L><D><R><I><S><D><A><I><T><H><L><N><P><E><N><V><T><D><V><S><L><G><I><S><S><N><E><Q><D><Q><G><S><D><K><G><E><N><E><A><M><E><S><S><G><K><R><A><P><Q><C><Y><P><S><S><V><N><S><A><R><T><V><M><L><F><N><L><G><S><A><Y><C><L><R><S><E><Y><D><K><A><R><K><C><L><H><Q><A><A><S><M><I><H><P><K><E><V><P><P><E><A><I><L><L><A><V><Y><L><E><L><Q><N><G><N><T><Q><L><A><L><Q><I><I><K><R><N><Q><L><L><P><A><V><K><T><H><S><E><V><R><K><K><P><V><F><Q><P><V><H><P><I><Q><P><I><Q><M><P><A><F><T><T><V><Q><R><K>
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.<BOP>
Q9H9A5
Q92546
RGP1_HUMAN
null
Homo
<M><I><E><V><V><A><E><L><S><R><G><P><V><F><L><A><G><E><A><L><E><C><V><V><T><V><T><N><P><L><P><P><T><A><T><S><A><S><S><E><A><L><A><W><A><S><A><Q><I><H><C><Q><F><H><A><S><E><S><R><V><A><L><P><P><P><D><S><S><Q><P><D><V><Q><P><D><S><Q><T><V><F><L><P><H><R><G><E><R><G><Q><C><I><L><S><T><P><P><K><I><L><F><C><D><L><R><L><D><P><G><E><S><K><S><Y><S><Y><S><E><V><L><P><I><E><G><P><P><S><F><R><G><Q><S><V><K><Y><V><Y><K><L><T><I><G><C><Q><R><V><N><S><P><I><T><L><L><R><V><P><L><R><V><L><V><L><T><G><L><Q><D><V><R><F><P><Q><D><E><A><V><A><P><S><S><P><F><L><E><E><D><E><G><G><K><K><D><S><W><L><A><E><L><A><G><E><R><L><M><A><A><T><S><C><R><S><L><H><L><Y><N><I><S><D><G><R><G><K><V><G><T><F><G><I><F><K><S><V><Y><R><L><G><E><D><V><V><G><T><L><N><L><G><E><G><T><V><A><C><L><Q><F><S><V><S><L><Q><T><E><E><R><V><Q><P><E><Y><Q><R><R><R><G><A><G><G><V><P><S><V><S><H><V><T><H><A><R><H><Q><E><S><C><L><H><T><T><R><T><S><F><S><L><P><I><P><L><S><S><T><P><G><F><C><T><A><I><V><S><L><K><W><R><L><H><F><E><F><V><T><S><R><E><P><G><L><V><L><L><P><P><V><E><Q><P><E><P><T><T><W><T><G><P><E><Q><V><P><V><D><T><F><S><W><D><L><P><I><K><V><L><P><T><S><P><T><L><A><S><Y><A><A><P><G><P><S><T><S><T><I><T><I>
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.<BOP>
Q92546
P57053
H2BFS_HUMAN
Histone H2B.s
Homo
<M><P><E><P><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><R><K><R><K><R><S><R><K><E><S><Y><S><V><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><P><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><A><K>
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<BOP>
P57053
Q6PII5
HAGHL_HUMAN
Hydroxyacylglutathione hydrolase-like protein
Homo
<M><K><V><K><V><I><P><V><L><E><D><N><Y><M><Y><L><V><I><E><E><L><T><R><E><A><V><A><V><D><V><A><V><P><K><R><L><L><E><I><V><G><R><E><G><V><S><L><T><A><V><L><T><T><H><H><H><W><D><H><A><R><G><N><P><E><L><A><R><L><R><P><G><L><A><V><L><G><A><D><E><R><I><F><S><L><T><R><R><L><A><H><G><E><E><L><R><F><G><A><I><H><V><R><C><L><L><T><P><G><H><T><A><G><H><M><S><Y><F><L><W><E><D><D><C><P><D><P><P><A><L><F><S><G><D><A><L><S><V><A><G><C><G><S><C><L><E><G><S><A><Q><Q><M><Y><Q><S><L><A><E><L><G><T><L><P><P><E><T><K><V><F><C><G><H><E><H><T><L><S><N><L><E><F><A><Q><K><V><E><P><C><N><D><H><V><R><A><K><L><S><W><A><K><A><R><P><L><S><R><R><G><K><R><V><G><G><E><G><T><G><F><G><V><G><G><A><L><R><Q><G><L><M><V><T><G><A><C><G><H><S><R><R><G><M><R><M><T><C><P><L><C><R><R><L><W><A><R><S><A><S><T><T><P><S><C><G><W><R><E><Y><G><C><C><P><G><A><S><T><V><T><W><T><L><R><K><A><S><G><D><C><V><L><G>
Hydrolase acting on ester bonds.<BOP>
Q6PII5
Q9Y608
LRRF2_HUMAN
Leucine-rich repeat flightless-interacting protein 2
Homo
<M><G><T><P><A><S><G><R><K><R><T><P><V><K><D><R><F><S><A><E><D><E><A><L><S><N><I><A><R><E><A><E><A><R><L><A><A><K><R><A><A><R><A><E><A><R><D><I><R><M><R><E><L><E><R><Q><Q><K><E><Y><S><L><H><S><F><D><R><K><W><G><Q><I><Q><K><W><L><E><D><S><E><R><A><R><Y><S><H><R><S><S><H><H><R><P><Y><L><G><V><E><D><A><L><S><I><R><S><V><G><S><H><R><Y><D><M><F><K><D><R><S><S><R><L><S><S><L><N><H><S><Y><S><H><S><H><G><M><K><K><R><S><S><D><S><H><K><D><L><L><S><G><L><Y><F><D><Q><R><N><Y><S><S><L><R><H><S><K><P><T><S><A><Y><Y><T><R><Q><S><S><S><L><Y><S><D><P><L><A><T><Y><K><S><D><R><A><S><P><T><A><N><S><G><L><L><R><S><A><S><L><A><S><L><Y><N><G><G><L><Y><N><P><Y><G><P><R><T><P><S><E><C><S><Y><Y><S><S><R><I><S><S><A><R><S><S><P><G><F><T><N><D><D><T><A><S><I><V><S><S><D><R><A><S><R><G><R><R><E><S><V><V><S><A><A><D><Y><F><S><R><S><N><R><R><G><S><V><V><S><E><V><D><D><I><S><I><P><D><L><S><S><L><D><E><K><S><D><K><Q><Y><A><E><N><Y><T><R><P><S><S><R><N><S><A><S><A><T><T><P><L><S><G><N><S><S><R><R><G><S><G><D><T><S><S><L><I><D><P><D><T><S><L><S><E><L><R><D><I><Y><D><L><K><D><Q><I><Q><D><V><E><G><R><Y><M><Q><G><L><K><E><L><K><E><S><L><S><E><V><E><E><K><Y><K><K><A><M><V><S><N><A><Q><L><D><N><E><K><N><N><L><I><Y><Q><V><D><T><L><K><D><V><I><E><E><Q><E><E><Q><M><A><E><F><Y><R><E><N><E><E><K><S><K><E><L><E><R><Q><K><H><M><C><S><V><L><Q><H><K><M><E><E><L><K><E><G><L><R><Q><R><D><E><L><I><E><E><K><Q><R><M><Q><Q><K><I><D><T><M><T><K><E><V><F><D><L><Q><E><T><L><L><W><K><D><K><K><I><G><A><L><E><K><Q><K><E><Y><I><A><C><L><R><N><E><R><D><M><L><R><E><E><L><A><D><L><Q><E><T><V><K><T><G><E><K><H><G><L><V><I><I><P><D><G><T><P><N><G><D><V><S><H><E><P><V><A><G><A><I><T><V><V><S><Q><E><A><A><Q><V><L><E><S><A><G><E><G><P><L><D><V><R><L><R><K><L><A><G><E><K><E><E><L><L><S><Q><I><R><K><L><K><L><Q><L><E><E><E><R><Q><K><C><S><R><N><D><G><T><V><G><D><L><A><G><L><Q><N><G><S><D><L><Q><F><I><E><M><Q><R><D><A><N><R><Q><I><S><E><Y><K><F><K><L><S><K><A><E><Q><D><I><T><T><L><E><Q><S><I><S><R><L><E><G><Q><V><L><R><Y><K><T><A><A><E><N><A><E><K><V><E><D><E><L><K><A><E><K><R><K><L><Q><R><E><L><R><T><A><L><D><K><I><E><E><M><E><M><T><N><S><H><L><A><K><R><L><E><K><M><K><A><N><R><T><A><L><L><A><Q><Q>
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.<BOP>
Q9Y608
Q5TA77
LCE3B_HUMAN
Late envelope protein 14
Homo
<M><S><C><Q><Q><N><Q><Q><Q><C><Q><P><L><P><K><C><P><S><P><K><C><P><P><K><S><S><A><Q><C><L><P><P><A><S><S><C><C><A><P><R><P><G><C><C><G><G><P><S><S><E><G><G><C><C><L><S><H><H><R><C><C><R><S><H><R><C><R><R><Q><S><S><N><S><C><D><R><G><S><G><Q><Q><D><G><A><S><D><C><G><Y><G><S><G><G><C><C>
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens .<BOP>
Q5TA77
P01185
NEU2_HUMAN
Copeptin
Homo
<M><P><D><T><M><L><P><A><C><F><L><G><L><L><A><F><S><S><A><C><Y><F><Q><N><C><P><R><G><G><K><R><A><M><S><D><L><E><L><R><Q><C><L><P><C><G><P><G><G><K><G><R><C><F><G><P><S><I><C><C><A><D><E><L><G><C><F><V><G><T><A><E><A><L><R><C><Q><E><E><N><Y><L><P><S><P><C><Q><S><G><Q><K><A><C><G><S><G><G><R><C><A><A><F><G><V><C><C><N><D><E><S><C><V><T><E><P><E><C><R><E><G><F><H><R><R><A><R><A><S><D><R><S><N><A><T><Q><L><D><G><P><A><G><A><L><L><L><R><L><V><Q><L><A><G><A><P><E><P><F><E><P><A><Q><P><D><A><Y>
Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) .<BOP>
P01185
P01033
TIMP1_HUMAN
Tissue inhibitor of metalloproteinases 1
Homo
<M><A><P><F><E><P><L><A><S><G><I><L><L><L><L><W><L><I><A><P><S><R><A><C><T><C><V><P><P><H><P><Q><T><A><F><C><N><S><D><L><V><I><R><A><K><F><V><G><T><P><E><V><N><Q><T><T><L><Y><Q><R><Y><E><I><K><M><T><K><M><Y><K><G><F><Q><A><L><G><D><A><A><D><I><R><F><V><Y><T><P><A><M><E><S><V><C><G><Y><F><H><R><S><H><N><R><S><E><E><F><L><I><A><G><K><L><Q><D><G><L><L><H><I><T><T><C><S><F><V><A><P><W><N><S><L><S><L><A><Q><R><R><G><F><T><K><T><Y><T><V><G><C><E><E><C><T><V><F><P><C><L><S><I><P><C><K><L><Q><S><G><T><H><C><L><W><T><D><Q><L><L><Q><G><S><E><K><G><F><Q><S><R><H><L><A><C><L><P><R><E><P><G><L><C><T><W><Q><S><L><R><S><Q><I><A>
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.<BOP>
P01033
P01037
CYTN_HUMAN
Salivary cystatin-SA-1
Homo
<M><A><Q><Y><L><S><T><L><L><L><L><L><A><T><L><A><V><A><L><A><W><S><P><K><E><E><D><R><I><I><P><G><G><I><Y><N><A><D><L><N><D><E><W><V><Q><R><A><L><H><F><A><I><S><E><Y><N><K><A><T><K><D><D><Y><Y><R><R><P><L><R><V><L><R><A><R><Q><Q><T><V><G><G><V><N><Y><F><F><D><V><E><V><G><R><T><I><C><T><K><S><Q><P><N><L><D><T><C><A><F><H><E><Q><P><E><L><Q><K><K><Q><L><C><S><F><E><I><Y><E><V><P><W><E><N><R><R><S><L><V><K><S><R><C><Q><E><S>
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.<BOP>
P01037
Q13886
KLF9_HUMAN
Transcription factor BTEB1
Homo
<M><S><A><A><A><Y><M><D><F><V><A><A><Q><C><L><V><S><I><S><N><R><A><A><V><P><E><H><G><V><A><P><D><A><E><R><L><R><L><P><E><R><E><V><T><K><E><H><G><D><P><G><D><T><W><K><D><Y><C><T><L><V><T><I><A><K><S><L><L><D><L><N><K><Y><R><P><I><Q><T><P><S><V><C><S><D><S><L><E><S><P><D><E><D><M><G><S><D><S><D><V><T><T><E><S><G><S><S><P><S><H><S><P><E><E><R><Q><D><P><G><S><A><P><S><P><L><S><L><L><H><P><G><V><A><A><K><G><K><H><A><S><E><K><R><H><K><C><P><Y><S><G><C><G><K><V><Y><G><K><S><S><H><L><K><A><H><Y><R><V><H><T><G><E><R><P><F><P><C><T><W><P><D><C><L><K><K><F><S><R><S><D><E><L><T><R><H><Y><R><T><H><T><G><E><K><Q><F><R><C><P><L><C><E><K><R><F><M><R><S><D><H><L><T><K><H><A><R><R><H><T><E><F><H><P><S><M><I><K><R><S><K><K><A><L><A><N><A><L>
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation .<BOP>
Q13886
Q5T6F0
DCA12_HUMAN
WD repeat-containing protein 40A
Homo
<M><A><R><K><V><V><S><R><K><R><K><A><P><A><S><P><G><A><G><S><D><A><Q><G><P><Q><F><G><W><D><H><S><L><H><K><R><K><R><L><P><P><V><K><R><S><L><V><Y><Y><L><K><N><R><E><V><R><L><Q><N><E><T><S><Y><S><R><V><L><H><G><Y><A><A><Q><Q><L><P><S><L><L><K><E><R><E><F><H><L><G><T><L><N><K><V><F><A><S><Q><W><L><N><H><R><Q><V><V><C><G><T><K><C><N><T><L><F><V><V><D><V><Q><T><S><Q><I><T><K><I><P><I><L><K><D><R><E><P><G><G><V><T><Q><Q><G><C><G><I><H><A><I><E><L><N><P><S><R><T><L><L><A><T><G><G><D><N><P><N><S><L><A><I><Y><R><L><P><T><L><D><P><V><C><V><G><D><D><G><H><K><D><W><I><F><S><I><A><W><I><S><D><T><M><A><V><S><G><S><R><D><G><S><M><G><L><W><E><V><T><D><D><V><L><T><K><S><D><A><R><H><N><V><S><R><V><P><V><Y><A><H><I><T><H><K><A><L><K><D><I><P><K><E><D><T><N><P><D><N><C><K><V><R><A><L><A><F><N><N><K><N><K><E><L><G><A><V><S><L><D><G><Y><F><H><L><W><K><A><E><N><T><L><S><K><L><L><S><T><K><L><P><Y><C><R><E><N><V><C><L><A><Y><G><S><E><W><S><V><Y><A><V><G><S><Q><A><H><V><S><F><L><D><P><R><Q><P><S><Y><N><V><K><S><V><C><S><R><E><R><G><S><G><I><R><S><V><S><F><Y><E><H><I><I><T><V><G><T><G><Q><G><S><L><L><F><Y><D><I><R><A><Q><R><F><L><E><E><R><L><S><A><C><Y><G><S><K><P><R><L><A><G><E><N><L><K><L><T><T><G><K><G><W><L><N><H><D><E><T><W><R><N><Y><F><S><D><I><D><F><F><P><N><A><V><Y><T><H><C><Y><D><S><S><G><T><K><L><F><V><A><G><G><P><L><P><S><G><L><H><G><N><Y><A><G><L><W><S>
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation . Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy .<BOP>
Q5T6F0
P53367
ARFP1_HUMAN
ADP-ribosylation factor-interacting protein 1
Homo
<M><A><Q><E><S><P><K><N><S><A><A><E><I><P><V><T><S><N><G><E><V><D><D><S><R><E><H><S><F><N><R><D><L><K><H><S><L><P><S><G><L><G><L><S><E><T><Q><I><T><S><H><G><F><D><N><T><K><E><G><V><I><E><A><G><A><F><Q><G><S><P><A><P><P><L><P><S><V><M><S><P><S><R><V><A><A><S><R><L><A><Q><Q><G><S><D><L><I><V><P><A><G><G><Q><R><T><Q><T><K><S><G><P><V><I><L><A><D><E><I><K><N><P><A><M><E><K><L><E><L><V><R><K><W><S><L><N><T><Y><K><C><T><R><Q><I><I><S><E><K><L><G><R><G><S><R><T><V><D><L><E><L><E><A><Q><I><D><I><L><R><D><N><K><K><K><Y><E><N><I><L><K><L><A><Q><T><L><S><T><Q><L><F><Q><M><V><H><T><Q><R><Q><L><G><D><A><F><A><D><L><S><L><K><S><L><E><L><H><E><E><F><G><Y><N><A><D><T><Q><K><L><L><A><K><N><G><E><T><L><L><G><A><I><N><F><F><I><A><S><V><N><T><L><V><N><K><T><I><E><D><T><L><M><T><V><K><Q><Y><E><S><A><R><I><E><Y><D><A><Y><R><T><D><L><E><E><L><N><L><G><P><R><D><A><N><T><L><P><K><I><E><Q><S><Q><H><L><F><Q><A><H><K><E><K><Y><D><K><M><R><N><D><V><S><V><K><L><K><F><L><E><E><N><K><V><K><V><L><H><N><Q><L><V><L><F><H><N><A><I><A><A><Y><F><A><G><N><Q><K><Q><L><E><Q><T><L><K><Q><F><H><I><K><L><K><T><P><G><V><D><A><P><S><W><L><E><E><Q>
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network . Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold . Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs . In turn, ARFs induce fission . Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells .<BOP>
P53367
P05387
RLA2_HUMAN
Renal carcinoma antigen NY-REN-44
Homo
<M><R><Y><V><A><S><Y><L><L><A><A><L><G><G><N><S><S><P><S><A><K><D><I><K><K><I><L><D><S><V><G><I><E><A><D><D><D><R><L><N><K><V><I><S><E><L><N><G><K><N><I><E><D><V><I><A><Q><G><I><G><K><L><A><S><V><P><A><G><G><A><V><A><V><S><A><A><P><G><S><A><A><P><A><A><G><S><A><P><A><A><A><E><E><K><K><D><E><K><K><E><E><S><E><E><S><D><D><D><M><G><F><G><L><F><D>
Plays an important role in the elongation step of protein synthesis.<BOP>
P05387
Q96D21
RHES_HUMAN
Tumor endothelial marker 2
Homo
<M><M><K><T><L><S><S><G><N><C><T><L><S><V><P><A><K><N><S><Y><R><M><V><V><L><G><A><S><R><V><G><K><S><S><I><V><S><R><F><L><N><G><R><F><E><D><Q><Y><T><P><T><I><E><D><F><H><R><K><V><Y><N><I><R><G><D><M><Y><Q><L><D><I><L><D><T><S><G><N><H><P><F><P><A><M><R><R><L><S><I><L><T><G><D><V><F><I><L><V><F><S><L><D><N><R><E><S><F><D><E><V><K><R><L><Q><K><Q><I><L><E><V><K><S><C><L><K><N><K><T><K><E><A><A><E><L><P><M><V><I><C><G><N><K><N><D><H><G><E><L><C><R><Q><V><P><T><T><E><A><E><L><L><V><S><G><D><E><N><C><A><Y><F><E><V><S><A><K><K><N><T><N><V><D><E><M><F><Y><V><L><F><S><M><A><K><L><P><H><E><M><S><P><A><L><H><R><K><I><S><V><Q><Y><G><D><A><F><H><P><R><P><F><C><M><R><R><V><K><E><M><D><A><Y><G><M><V><S><P><F><A><R><R><P><S><V><N><S><D><L><K><Y><I><K><A><K><V><L><R><E><G><Q><A><R><E><R><D><K><C><T><I><Q>
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.<BOP>
Q96D21
Q8IXS8
F126B_HUMAN
Protein FAM126B
Homo
<M><L><G><T><D><R><C><V><V><E><E><W><L><S><E><F><K><A><L><P><D><T><Q><I><T><S><Y><A><A><T><L><H><R><K><K><T><L><V><P><A><L><Y><K><V><I><Q><D><S><N><N><E><L><L><E><P><V><C><H><Q><L><F><E><L><Y><R><S><S><E><V><R><L><K><R><F><T><L><Q><F><L><P><E><L><M><W><V><Y><L><R><L><T><V><S><R><D><R><Q><S><N><G><C><I><E><A><L><L><L><G><I><Y><N><L><E><I><A><D><K><D><G><N><N><K><V><L><S><F><T><I><P><S><L><S><K><P><S><I><Y><H><E><P><S><T><I><G><S><M><A><L><T><E><G><A><L><C><Q><H><D><L><I><R><V><V><Y><S><D><L><H><P><Q><R><E><T><F><T><A><Q><N><R><F><E><V><L><S><F><L><M><L><C><Y><N><S><A><I><V><Y><M><P><A><S><S><Y><Q><S><L><C><R><M><G><S><R><V><C><V><S><G><F><P><R><Q><H><E><K><H><W><K><E><L><C><G><R><I><V><L><D><P><E><F><M><V><Q><L><L><T><G><V><Y><Y><A><M><Y><N><G><Q><W><D><L><G><Q><E><V><L><D><D><I><I><Y><R><A><Q><L><E><L><F><S><Q><P><L><L><V><A><N><A><M><K><N><S><L><P><F><D><A><P><D><S><T><Q><E><G><Q><K><V><L><K><V><E><V><T><P><T><V><P><R><I><S><R><T><A><I><T><T><A><S><I><R><R><H><R><W><R><R><E><G><A><E><G><V><N><G><G><E><E><S><V><N><L><N><D><A><D><E><G><F><S><S><G><A><S><L><S><S><Q><P><I><G><T><K><P><S><S><S><S><Q><R><G><S><L><R><K><V><A><T><G><R><S><A><K><D><K><E><T><A><S><A><I><K><S><S><E><S><P><R><D><S><V><V><R><K><Q><Y><V><Q><Q><P><T><D><L><S><V><D><S><V><E><L><T><P><M><K><K><H><L><S><L><P><A><G><Q><V><V><P><K><I><N><S><L><S><L><I><R><T><A><S><A><S><S><S><K><S><F><D><Y><V><N><G><S><Q><A><S><T><S><I><G><V><G><T><E><G><G><T><N><L><A><A><N><N><A><N><R><Y><S><T><V><S><L><Q><E><D><R><L><G><Q><A><G><E><G><K><E><L><L><S><P><G><A><P><L><T><K><Q><S><R><S><P><S><F><N><M><Q><L><I><S><Q><V>
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.<BOP>
Q8IXS8
Q8WYK2
JDP2_HUMAN
Jun dimerization protein 2
Homo
<M><M><P><G><Q><I><P><D><P><S><V><T><T><G><S><L><P><G><L><G><P><L><T><G><L><P><S><S><A><L><T><V><E><E><L><K><Y><A><D><I><R><N><L><G><A><M><I><A><P><L><H><F><L><E><V><K><L><G><K><R><P><Q><P><V><K><S><E><L><D><E><E><E><E><R><R><K><R><R><R><E><K><N><K><V><A><A><A><R><C><R><N><K><K><K><E><R><T><E><F><L><Q><R><E><S><E><R><L><E><L><M><N><A><E><L><K><T><Q><I><E><E><L><K><Q><E><R><Q><Q><L><I><L><M><L><N><R><H><R><P><T><C><I><V><R><T><D><S><V><K><T><P><E><S><E><G><N><P><L><L><E><Q><L><E><K><K>
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.<BOP>
Q8WYK2
Q9Y5L3
ENTP2_HUMAN
Ecto-ATP diphosphohydrolase 2
Homo
<M><A><G><K><V><R><S><L><L><P><P><L><L><L><A><A><A><G><L><A><G><L><L><L><L><C><V><P><T><R><D><V><R><E><P><P><A><L><K><Y><G><I><V><L><D><A><G><S><S><H><T><S><M><F><I><Y><K><W><P><A><D><K><E><N><D><T><G><I><V><G><Q><H><S><S><C><D><V><P><G><G><G><I><S><S><Y><A><D><N><P><S><G><A><S><Q><S><L><V><G><C><L><E><Q><A><L><Q><D><V><P><K><E><R><H><A><G><T><P><L><Y><L><G><A><T><A><G><M><R><L><L><N><L><T><N><P><E><A><S><T><S><V><L><M><A><V><T><H><T><L><T><Q><Y><P><F><D><F><R><G><A><R><I><L><S><G><Q><E><E><G><V><F><G><W><V><T><A><N><Y><L><L><E><N><F><I><K><Y><G><W><V><G><R><W><F><R><P><R><K><G><T><L><G><A><M><D><L><G><G><A><S><T><Q><I><T><F><E><T><T><S><P><A><E><D><R><A><S><E><V><Q><L><H><L><Y><G><Q><H><Y><R><V><Y><T><H><S><F><L><C><Y><G><R><D><Q><V><L><Q><R><L><L><A><S><A><L><Q><T><H><G><F><H><P><C><W><P><R><G><F><S><T><Q><V><L><L><G><D><V><Y><Q><S><P><C><T><M><A><Q><R><P><Q><N><F><N><S><S><A><R><V><S><L><S><G><S><S><D><P><H><L><C><R><D><L><V><S><G><L><F><S><F><S><S><C><P><F><S><R><C><S><F><N><G><V><F><Q><P><P><V><A><G><N><F><V><A><F><S><A><F><F><Y><T><V><D><F><L><R><T><S><M><G><L><P><V><A><T><L><Q><Q><L><E><A><A><A><V><N><V><C><N><Q><T><W><A><Q><L><Q><A><R><V><P><G><Q><R><A><R><L><A><D><Y><C><A><G><A><M><F><V><Q><Q><L><L><S><R><G><Y><G><F><D><E><R><A><F><G><G><V><I><F><Q><K><K><A><A><D><T><A><V><G><W><A><L><G><Y><M><L><N><L><T><N><L><I><P><A><D><P><P><G><L><R><K><G><T><D><F><S><S><W><V><V><L><L><L><L><F><A><S><A><L><L><A><A><L><V><L><L><L><R><Q><V><H><S><A><K><L><P><S><T><I>
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.<BOP>
Q9Y5L3
Q9UKB5
AJAP1_HUMAN
Membrane protein shrew-1
Homo
<M><W><I><Q><Q><L><L><G><L><S><S><M><S><I><R><W><P><G><R><P><L><G><S><H><A><W><I><L><I><A><M><F><Q><L><A><V><D><L><P><A><C><E><A><L><G><P><G><P><E><F><W><L><L><P><R><S><P><P><R><P><P><R><L><W><S><F><R><S><G><Q><P><A><R><V><P><A><P><V><W><S><P><R><P><P><R><V><E><R><I><H><G><Q><M><Q><M><P><R><A><R><R><A><H><R><P><R><D><Q><A><A><A><L><V><P><K><A><G><L><A><K><P><P><A><A><A><K><S><S><P><S><L><A><S><S><S><S><S><S><S><S><A><V><A><G><G><A><P><E><Q><Q><A><L><L><R><R><G><K><R><H><L><Q><G><D><G><L><S><S><F><D><S><R><G><S><R><P><T><T><E><T><E><F><I><A><W><G><P><T><G><D><E><E><A><L><E><S><N><T><F><P><G><V><Y><G><P><T><T><V><S><I><L><Q><T><R><K><T><T><V><A><A><T><T><T><T><T><T><T><A><T><P><M><T><L><Q><T><K><G><F><T><E><S><L><D><P><R><R><R><I><P><G><G><V><S><T><T><E><P><S><T><S><P><S><N><N><G><E><V><T><Q><P><P><R><I><L><G><E><A><S><G><L><A><V><H><Q><I><I><T><I><T><V><S><L><I><M><V><I><A><A><L><I><T><T><L><V><L><K><N><C><C><A><Q><S><G><N><T><R><R><N><S><H><Q><R><K><T><N><Q><Q><E><E><S><C><Q><N><L><T><D><F><P><S><A><R><V><P><S><S><L><D><I><F><T><A><Y><N><E><T><L><Q><C><S><H><E><C><V><R><A><S><V><P><V><Y><T><D><E><T><L><H><S><T><T><G><E><Y><K><S><T><F><N><G><N><R><P><S><S><S><D><R><H><L><I><P><V><A><F><V><S><E><K><W><F><E><I><S><C>
Plays a role in cell adhesion and cell migration.<BOP>
Q9UKB5
Q9P2W7
B3GA1_HUMAN
UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
Homo
<M><P><K><R><R><D><I><L><A><I><V><L><I><V><L><P><W><T><L><L><I><T><V><W><H><Q><S><T><L><A><P><L><L><A><V><H><K><D><E><G><S><D><P><R><R><E><T><P><P><G><A><D><P><R><E><Y><C><T><S><D><R><D><I><V><E><V><V><R><T><E><Y><V><Y><T><R><P><P><P><W><S><D><T><L><P><T><I><H><V><V><T><P><T><Y><S><R><P><V><Q><K><A><E><L><T><R><M><A><N><T><L><L><H><V><P><N><L><H><W><L><V><V><E><D><A><P><R><R><T><P><L><T><A><R><L><L><R><D><T><G><L><N><Y><T><H><L><H><V><E><T><P><R><N><Y><K><L><R><G><D><A><R><D><P><R><I><P><R><G><T><M><Q><R><N><L><A><L><R><W><L><R><E><T><F><P><R><N><S><S><Q><P><G><V><V><Y><F><A><D><D><D><N><T><Y><S><L><E><L><F><E><E><M><R><S><T><R><R><V><S><V><W><P><V><A><F><V><G><G><L><R><Y><E><A><P><R><V><N><G><A><G><K><V><V><G><W><K><T><V><F><D><P><H><R><P><F><A><I><D><M><A><G><F><A><V><N><L><R><L><I><L><Q><R><S><Q><A><Y><F><K><L><R><G><V><K><G><G><Y><Q><E><S><S><L><L><R><E><L><V><T><L><N><D><L><E><P><K><A><A><N><C><T><K><I><L><V><W><H><T><R><T><E><K><P><V><L><V><N><E><G><K><K><G><F><T><D><P><S><V><E><I>
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.<BOP>
Q9P2W7
O75718
CRTAP_HUMAN
Cartilage-associated protein
Homo
<M><E><P><G><R><R><G><A><A><A><L><L><A><L><L><C><V><A><C><A><L><R><A><G><R><A><Q><Y><E><R><Y><S><F><R><S><F><P><R><D><E><L><M><P><L><E><S><A><Y><R><H><A><L><D><K><Y><S><G><E><H><W><A><E><S><V><G><Y><L><E><I><S><L><R><L><H><R><L><L><R><D><S><E><A><F><C><H><R><N><C><S><A><A><P><Q><P><E><P><A><A><G><L><A><S><Y><P><E><L><R><L><F><G><G><L><L><R><R><A><H><C><L><K><R><C><K><Q><G><L><P><A><F><R><Q><S><Q><P><S><R><E><V><L><A><D><F><Q><R><R><E><P><Y><K><F><L><Q><F><A><Y><F><K><A><N><N><L><P><K><A><I><A><A><A><H><T><F><L><L><K><H><P><D><D><E><M><M><K><R><N><M><A><Y><Y><K><S><L><P><G><A><E><D><Y><I><K><D><L><E><T><K><S><Y><E><S><L><F><I><R><A><V><R><A><Y><N><G><E><N><W><R><T><S><I><T><D><M><E><L><A><L><P><D><F><F><K><A><F><Y><E><C><L><A><A><C><E><G><S><R><E><I><K><D><F><K><D><F><Y><L><S><I><A><D><H><Y><V><E><V><L><E><C><K><I><Q><C><E><E><N><L><T><P><V><I><G><G><Y><P><V><E><K><F><V><A><T><M><Y><H><Y><L><Q><F><A><Y><Y><K><L><N><D><L><K><N><A><A><P><C><A><V><S><Y><L><L><F><D><Q><N><D><K><V><M><Q><Q><N><L><V><Y><Y><Q><Y><H><R><D><T><W><G><L><S><D><E><H><F><Q><P><R><P><E><A><V><Q><F><F><N><V><T><T><L><Q><K><E><L><Y><D><F><A><K><E><N><I><M><D><D><D><E><G><E><V><V><E><Y><V><D><D><L><L><E><L><E><E><T><S>
Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.<BOP>
O75718
Q9Y271
CLTR1_HUMAN
HMTMF81
Homo
<M><D><E><T><G><N><L><T><V><S><S><A><T><C><H><D><T><I><D><D><F><R><N><Q><V><Y><S><T><L><Y><S><M><I><S><V><V><G><F><F><G><N><G><F><V><L><Y><V><L><I><K><T><Y><H><K><K><S><A><F><Q><V><Y><M><I><N><L><A><V><A><D><L><L><C><V><C><T><L><P><L><R><V><V><Y><Y><V><H><K><G><I><W><L><F><G><D><F><L><C><R><L><S><T><Y><A><L><Y><V><N><L><Y><C><S><I><F><F><M><T><A><M><S><F><F><R><C><I><A><I><V><F><P><V><Q><N><I><N><L><V><T><Q><K><K><A><R><F><V><C><V><G><I><W><I><F><V><I><L><T><S><S><P><F><L><M><A><K><P><Q><K><D><E><K><N><N><T><K><C><F><E><P><P><Q><D><N><Q><T><K><N><H><V><L><V><L><H><Y><V><S><L><F><V><G><F><I><I><P><F><V><I><I><I><V><C><Y><T><M><I><I><L><T><L><L><K><K><S><M><K><K><N><L><S><S><H><K><K><A><I><G><M><I><M><V><V><T><A><A><F><L><V><S><F><M><P><Y><H><I><Q><R><T><I><H><L><H><F><L><H><N><E><T><K><P><C><D><S><V><L><R><M><Q><K><S><V><V><I><T><L><S><L><A><A><S><N><C><C><F><D><P><L><L><Y><F><F><S><G><G><N><F><R><K><R><L><S><T><F><R><K><H><S><L><S><S><V><T><Y><V><P><R><K><K><A><S><L><P><E><K><G><E><E><I><C><K><V>
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.<BOP>
Q9Y271
P09914
IFIT1_HUMAN
Interferon-induced 56 kDa protein
Homo
<M><S><T><N><G><D><D><H><Q><V><K><D><S><L><E><Q><L><R><C><H><F><T><W><E><L><S><I><D><D><D><E><M><P><D><L><E><N><R><V><L><D><Q><I><E><F><L><D><T><K><Y><S><V><G><I><H><N><L><L><A><Y><V><K><H><L><K><G><Q><N><E><E><A><L><K><S><L><K><E><A><E><N><L><M><Q><E><E><H><D><N><Q><A><N><V><R><S><L><V><T><W><G><N><F><A><W><M><Y><Y><H><M><G><R><L><A><E><A><Q><T><Y><L><D><K><V><E><N><I><C><K><K><L><S><N><P><F><R><Y><R><M><E><C><P><E><I><D><C><E><E><G><W><A><L><L><K><C><G><G><K><N><Y><E><R><A><K><A><C><F><E><K><V><L><E><V><D><P><E><N><P><E><S><S><A><G><Y><A><I><S><A><Y><R><L><D><G><F><K><L><A><T><K><N><H><K><P><F><S><L><L><P><L><R><Q><A><V><R><L><N><P><D><N><G><Y><I><K><V><L><L><A><L><K><L><Q><D><E><G><Q><E><A><E><G><E><K><Y><I><E><E><A><L><A><N><M><S><S><Q><T><Y><V><F><R><Y><A><A><K><F><Y><R><R><K><G><S><V><D><K><A><L><E><L><L><K><K><A><L><Q><E><T><P><T><S><V><L><L><H><H><Q><I><G><L><C><Y><K><A><Q><M><I><Q><I><K><E><A><T><K><G><Q><P><R><G><Q><N><R><E><K><L><D><K><M><I><R><S><A><I><F><H><F><E><S><A><V><E><K><K><P><T><F><E><V><A><H><L><D><L><A><R><M><Y><I><E><A><G><N><H><R><K><A><E><E><N><F><Q><K><L><L><C><M><K><P><V><V><E><E><T><M><Q><D><I><H><F><H><Y><G><R><F><Q><E><F><Q><K><K><S><D><V><N><A><I><I><H><Y><L><K><A><I><K><I><E><Q><A><S><L><T><R><D><K><S><I><N><S><L><K><K><L><V><L><R><K><L><R><R><K><A><L><D><L><E><S><L><S><L><L><G><F><V><Y><K><L><E><G><N><M><N><E><A><L><E><Y><Y><E><R><A><L><R><L><A><A><D><F><E><N><S><V><R><Q><G><P>
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<BOP>
P09914
O43315
AQP9_HUMAN
Small solute channel 1
Homo
<M><Q><P><E><G><A><E><K><G><K><S><F><K><Q><R><L><V><L><K><S><S><L><A><K><E><T><L><S><E><F><L><G><T><F><I><L><I><V><L><G><C><G><C><V><A><Q><A><I><L><S><R><G><R><F><G><G><V><I><T><I><N><V><G><F><S><M><A><V><A><M><A><I><Y><V><A><G><G><V><S><G><G><H><I><N><P><A><V><S><L><A><M><C><L><F><G><R><M><K><W><F><K><L><P><F><Y><V><G><A><Q><F><L><G><A><F><V><G><A><A><T><V><F><G><I><Y><Y><D><G><L><M><S><F><A><G><G><K><L><L><I><V><G><E><N><A><T><A><H><I><F><A><T><Y><P><A><P><Y><L><S><L><A><N><A><F><A><D><Q><V><V><A><T><M><I><L><L><I><I><V><F><A><I><F><D><S><R><N><L><G><A><P><R><G><L><E><P><I><A><I><G><L><L><I><I><V><I><A><S><S><L><G><L><N><S><G><C><A><M><N><P><A><R><D><L><S><P><R><L><F><T><A><L><A><G><W><G><F><E><V><F><R><A><G><N><N><F><W><W><I><P><V><V><G><P><L><V><G><A><V><I><G><G><L><I><Y><V><L><V><I><E><I><H><H><P><E><P><D><S><V><F><K><T><E><Q><S><E><D><K><P><E><K><Y><E><L><S><V><I><M>
Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.<BOP>
O43315
P42830
CXCL5_HUMAN
ENA-78(9-78)
Homo
<M><S><L><L><S><S><R><A><A><R><V><P><G><P><S><S><S><L><C><A><L><L><V><L><L><L><L><L><T><Q><P><G><P><I><A><S><A><G><P><A><A><A><V><L><R><E><L><R><C><V><C><L><Q><T><T><Q><G><V><H><P><K><M><I><S><N><L><Q><V><F><A><I><G><P><Q><C><S><K><V><E><V><V><A><S><L><K><N><G><K><E><I><C><L><D><P><E><A><P><F><L><K><K><V><I><Q><K><I><L><D><G><G><N><K><E><N>
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.<BOP>
P42830
Q8N103
TAGAP_HUMAN
T-cell activation GTPase-activating protein
Homo
<M><K><L><R><S><S><H><N><A><S><K><T><L><N><A><N><N><M><E><T><L><I><E><C><Q><S><E><G><D><I><K><E><H><P><L><L><A><S><C><E><S><E><D><S><I><C><Q><L><I><E><V><K><K><R><K><K><V><L><S><W><P><F><L><M><R><R><L><S><P><A><S><D><F><S><G><A><L><E><T><D><L><K><A><S><L><F><D><Q><P><L><S><I><I><C><G><D><S><D><T><L><P><R><P><I><Q><D><I><L><T><I><L><C><L><K><G><P><S><T><E><G><I><F><R><R><A><A><N><E><K><A><R><K><E><L><K><E><E><L><N><S><G><D><A><V><D><L><E><R><L><P><V><H><L><L><A><V><V><F><K><D><F><L><R><S><I><P><R><K><L><L><S><S><D><L><F><E><E><W><M><G><A><L><E><M><Q><D><E><E><D><R><I><E><A><L><K><Q><V><A><D><K><L><P><R><P><N><L><L><L><L><K><H><L><V><Y><V><L><H><L><I><S><K><N><S><E><V><N><R><M><D><S><S><N><L><A><I><C><I><G><P><N><M><L><T><L><E><N><D><Q><S><L><S><F><E><A><Q><K><D><L><N><N><K><V><K><T><L><V><E><F><L><I><D><N><C><F><E><I><F><G><E><N><I><P><V><H><S><S><I><T><S><D><D><S><L><E><H><T><D><S><S><D><V><S><T><L><Q><N><D><S><A><Y><D><S><N><D><P><D><V><E><S><N><S><S><S><G><I><S><S><P><S><R><Q><P><Q><V><P><M><A><T><A><A><G><L><D><S><A><G><P><Q><D><A><R><E><V><S><P><E><P><I><V><S><T><V><A><R><L><K><S><S><L><A><Q><P><D><R><R><Y><S><E><P><S><M><P><S><S><Q><E><C><L><E><S><R><V><T><N><Q><T><L><T><K><S><E><G><D><F><P><V><P><R><V><G><S><R><L><E><S><E><E><A><E><D><P><F><P><E><E><V><F><P><A><V><Q><G><K><T><K><R><P><V><D><L><K><I><K><N><L><A><P><G><S><V><L><P><R><A><L><V><L><K><A><F><S><S><S><S><L><D><A><S><S><D><S><S><P><V><A><S><P><S><S><P><K><R><N><F><F><S><R><H><Q><S><F><T><T><K><T><E><K><G><K><P><S><R><E><I><K><K><H><S><M><S><F><T><F><A><P><H><K><K><V><L><T><K><N><L><S><A><G><S><G><K><S><Q><D><F><T><R><D><H><V><P><R><G><V><R><K><E><S><Q><L><A><G><R><I><V><Q><E><N><G><C><E><T><H><N><Q><T><A><R><G><F><C><L><R><P><H><A><L><S><V><D><D><V><F><Q><G><A><D><W><E><R><P><G><S><P><P><S><Y><E><E><A><M><Q><G><P><A><A><R><L><V><A><S><E><S><Q><T><V><G><S><M><T><V><G><S><M><R><A><R><M><L><E><A><H><C><L><L><P><P><L><P><P><A><H><H><V><E><D><S><R><H><R><G><S><K><E><P><L><P><G><H><G><L><S><P><L><P><E><R><W><K><Q><S><R><T><V><H><A><S><G><D><S><L><G><H><V><S><G><P><G><R><P><E><L><L><P><L><R><T><V><S><E><S><V><Q><R><N><K><R><D><C><L><V><R><R><C><S><Q><P><V><F><E><A><D><Q><F><Q><Y><A><K><E><S><Y><I>
May function as a GTPase-activating protein and may play important roles during T-cell activation.<BOP>
Q8N103
Q7RTU3
OLIG3_HUMAN
Class E basic helix-loop-helix protein 20
Homo
<M><N><S><D><S><S><S><V><S><S><R><A><S><S><P><D><M><D><E><M><Y><L><R><D><H><H><H><R><H><H><H><H><Q><E><S><R><L><N><S><V><S><S><T><Q><G><D><M><M><Q><K><M><P><G><E><S><L><S><R><A><G><A><K><A><A><G><E><S><S><K><Y><K><I><K><K><Q><L><S><E><Q><D><L><Q><Q><L><R><L><K><I><N><G><R><E><R><K><R><M><H><D><L><N><L><A><M><D><G><L><R><E><V><M><P><Y><A><H><G><P><S><V><R><K><L><S><K><I><A><T><L><L><L><A><R><N><Y><I><L><M><L><T><S><S><L><E><E><M><K><R><L><V><G><E><I><Y><G><G><H><H><S><A><F><H><C><G><T><V><G><H><S><A><G><H><P><A><H><A><A><N><S><V><H><P><V><H><P><I><L><G><G><A><L><S><S><G><N><A><S><S><P><L><S><A><A><S><L><P><A><I><G><T><I><R><P><P><H><S><L><L><K><A><P><S><T><P><P><A><L><Q><L><G><S><G><F><Q><H><W><A><G><L><P><C><P><C><T><I><C><Q><M><P><P><P><P><H><L><S><A><L><S><T><A><N><M><A><R><L><S><A><E><S><K><D><L><L><K>
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.<BOP>
Q7RTU3
Q99816
TS101_HUMAN
ESCRT-I complex subunit TSG101
Homo
<M><A><V><S><E><S><Q><L><K><K><M><V><S><K><Y><K><Y><R><D><L><T><V><R><E><T><V><N><V><I><T><L><Y><K><D><L><K><P><V><L><D><S><Y><V><F><N><D><G><S><S><R><E><L><M><N><L><T><G><T><I><P><V><P><Y><R><G><N><T><Y><N><I><P><I><C><L><W><L><L><D><T><Y><P><Y><N><P><P><I><C><F><V><K><P><T><S><S><M><T><I><K><T><G><K><H><V><D><A><N><G><K><I><Y><L><P><Y><L><H><E><W><K><H><P><Q><S><D><L><L><G><L><I><Q><V><M><I><V><V><F><G><D><E><P><P><V><F><S><R><P><I><S><A><S><Y><P><P><Y><Q><A><T><G><P><P><N><T><S><Y><M><P><G><M><P><G><G><I><S><P><Y><P><S><G><Y><P><P><N><P><S><G><Y><P><G><C><P><Y><P><P><G><G><P><Y><P><A><T><T><S><S><Q><Y><P><S><Q><P><P><V><T><T><V><G><P><S><R><D><G><T><I><S><E><D><T><I><R><A><S><L><I><S><A><V><S><D><K><L><R><W><R><M><K><E><E><M><D><R><A><Q><A><E><L><N><A><L><K><R><T><E><E><D><L><K><K><G><H><Q><K><L><E><E><M><V><T><R><L><D><Q><E><V><A><E><V><D><K><N><I><E><L><L><K><K><K><D><E><E><L><S><S><A><L><E><K><M><E><N><Q><S><E><N><N><D><I><D><E><V><I><I><P><T><A><P><L><Y><K><Q><I><L><N><L><Y><A><E><E><N><A><I><E><D><T><I><F><Y><L><G><E><A><L><R><R><G><V><I><D><L><D><V><F><L><K><H><V><R><L><L><S><R><K><Q><F><Q><L><R><A><L><M><Q><K><A><R><K><T><A><G><L><S><D><L><Y>
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan . It may also play a role in the extracellular release of microvesicles that differ from the exosomes .<BOP>
Q99816
Q5T754
LCE1F_HUMAN
Late envelope protein 6
Homo
<M><S><C><Q><Q><S><Q><Q><Q><C><Q><P><P><P><K><C><T><P><K><C><P><P><K><C><P><T><P><K><C><P><P><K><C><P><P><K><C><P><P><V><S><S><C><C><S><V><S><S><G><G><C><C><G><S><S><S><G><G><C><C><S><S><G><G><G><G><C><C><S><S><G><G><G><G><C><C><L><S><H><H><R><R><R><R><S><H><R><H><R><P><Q><S><S><D><C><C><S><Q><P><S><A><G><S><S><C><C><G><G><G><S><G><Q><H><S><G><G><C><C>
Precursors of the cornified envelope of the stratum corneum.<BOP>
Q5T754
Q8N146
OR8H3_HUMAN
Olfactory receptor OR11-172
Homo
<M><M><G><R><R><N><D><T><N><V><A><D><F><I><L><T><G><L><S><D><S><E><E><V><Q><M><A><L><F><M><L><F><L><L><I><Y><L><I><T><M><L><G><N><V><G><M><L><L><I><I><R><L><D><L><Q><L><H><T><P><M><Y><F><F><L><T><H><L><S><F><I><D><L><S><Y><S><T><V><V><T><P><K><T><L><A><N><L><L><T><S><N><Y><I><S><F><T><G><C><F><A><Q><M><F><C><F><V><F><L><G><T><A><E><C><Y><L><L><S><S><M><A><Y><D><R><Y><A><A><I><C><S><P><L><H><Y><T><V><I><M><P><K><R><L><C><L><A><L><I><T><G><P><Y><V><I><G><F><M><D><S><F><V><N><V><V><S><M><S><R><L><H><F><C><D><S><N><I><I><H><H><F><F><C><D><T><S><P><I><L><A><L><S><C><T><D><T><D><N><T><E><M><L><I><F><I><I><A><G><S><T><L><M><V><S><L><I><T><I><S><A><S><Y><V><S><I><L><S><T><I><L><K><I><N><S><T><S><G><K><Q><K><A><F><S><T><C><V><S><H><L><L><G><V><T><I><F><Y><G><T><M><I><F><T><Y><L><K><P><R><K><S><Y><S><L><G><R><D><Q><V><A><P><V><F><Y><T><I><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><R><E><V><K><N><A><L><I><R><V><M><Q><R><R><Q><D><S><R>
Odorant receptor.<BOP>
Q8N146
O75648
MTU1_HUMAN
MTO2 homolog
Homo
<M><Q><A><L><R><H><V><V><C><A><L><S><G><G><V><D><S><A><V><A><A><L><L><L><R><R><R><G><Y><Q><V><T><G><V><F><M><K><N><W><D><S><L><D><E><H><G><V><C><T><A><D><K><D><C><E><D><A><Y><R><V><C><Q><I><L><D><I><P><F><H><Q><V><S><Y><V><K><E><Y><W><N><D><V><F><S><D><F><L><N><E><Y><E><K><G><R><T><P><N><P><D><I><V><C><N><K><H><I><K><F><S><C><F><F><H><Y><A><V><D><N><L><G><A><D><A><I><A><T><G><H><Y><A><R><T><S><L><E><D><E><E><V><F><E><Q><K><H><V><K><K><P><E><G><L><F><R><N><R><F><E><V><R><N><A><V><K><L><L><Q><A><A><D><S><F><K><D><Q><T><F><F><L><S><Q><V><S><Q><D><A><L><R><R><T><I><F><P><L><G><G><L><T><K><E><F><V><K><K><I><A><A><E><N><R><L><H><H><V><L><Q><K><K><E><S><M><G><M><C><F><I><G><K><R><N><F><E><H><F><L><L><Q><Y><L><Q><P><R><P><G><H><F><I><S><I><E><D><N><K><V><L><G><T><H><K><G><W><F><L><Y><T><L><G><Q><R><A><N><I><G><G><L><R><E><P><W><Y><V><V><E><K><D><S><V><K><G><D><V><F><V><A><P><R><T><D><H><P><A><L><Y><R><D><L><L><R><T><S><R><V><H><W><I><A><E><E><P><P><A><A><L><V><R><D><K><M><M><E><C><H><F><R><F><R><H><Q><M><A><L><V><P><C><V><L><T><L><N><Q><D><G><T><V><W><V><T><A><V><Q><A><V><R><A><L><A><T><G><Q><F><A><V><F><Y><K><G><D><E><C><L><G><S><G><K><I><L><R><L><G><P><S><A><Y><T><L><Q><K><G><Q><R><R><A><G><M><A><T><E><S><P><S><D><S><P><E><D><G><P><G><L><S><P><L><L>
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.<BOP>
O75648
O14880
MGST3_HUMAN
Microsomal glutathione S-transferase III
Homo
<M><A><V><L><S><K><E><Y><G><F><V><L><L><T><G><A><A><S><F><I><M><V><A><H><L><A><I><N><V><S><K><A><R><K><K><Y><K><V><E><Y><P><I><M><Y><S><T><D><P><E><N><G><H><I><F><N><C><I><Q><R><A><H><Q><N><T><L><E><V><Y><P><P><F><L><F><F><L><A><V><G><G><V><Y><H><P><R><I><A><S><G><L><G><L><A><W><I><V><G><R><V><L><Y><A><Y><G><Y><Y><T><G><E><P><S><K><R><S><R><G><A><L><G><S><I><A><L><L><G><L><V><G><T><T><V><C><S><A><F><Q><H><L><G><W><V><K><S><G><L><G><S><G><P><K><C><C><H>
Catalyzes oxydation of hydroxy-fatty acids . Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro . May participate in the lipid metabolism .<BOP>
O14880
Q8IYI8
ZN440_HUMAN
Zinc finger protein 440
Homo
<M><D><P><V><A><F><K><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><D><I><S><Q><R><K><L><Y><R><E><V><M><L><E><T><F><R><N><L><T><S><L><G><K><R><W><K><D><Q><N><I><E><Y><E><H><Q><N><P><R><R><N><F><R><S><L><I><E><E><K><V><N><E><I><K><D><D><S><H><C><G><E><T><F><T><P><V><P><D><D><R><L><N><F><Q><E><K><K><A><S><P><E><V><K><S><C><E><S><F><V><C><G><E><V><G><L><G><N><S><S><F><N><M><N><I><R><G><D><I><G><H><K><A><Y><E><Y><Q><E><Y><G><P><K><P><C><K><C><Q><Q><P><K><K><A><F><R><Y><R><P><S><F><R><T><Q><E><R><D><H><T><G><E><K><P><N><A><C><K><V><C><G><K><T><F><I><S><H><S><S><V><R><R><H><M><V><M><H><S><G><D><G><P><Y><K><C><K><F><C><G><K><A><F><H><C><L><R><L><Y><L><I><H><E><R><I><H><T><G><E><K><P><C><E><C><K><Q><C><G><K><S><F><S><Y><S><A><T><H><R><I><H><K><R><T><H><T><G><E><K><P><Y><E><Y><Q><E><C><G><K><A><F><H><S><P><R><S><Y><R><R><H><E><R><I><H><M><G><E><K><A><Y><Q><C><K><E><C><G><K><A><F><T><C><P><R><Y><V><R><I><H><E><R><T><H><S><R><K><N><L><Y><E><C><K><Q><C><G><K><A><L><S><S><L><T><S><F><Q><T><H><V><R><L><H><S><G><E><R><P><Y><E><C><K><I><C><G><K><D><F><C><S><V><N><S><F><Q><R><H><E><K><I><H><S><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><P><H><S><S><S><L><R><Y><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><H><L><R><V><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Y><V><N><N><L><Q><S><H><E><R><T><Q><T><H><I><R><I><H><S><G><E><R><R><Y><K><C><K><I><C><G><K><G><F><Y><C><P><K><S><F><Q><R><H><E><K><T><H><T><G><E><K><L><Y><E><C><K><Q><R><S><V><V><P><S><V><V><P><V><P><F><D><I><M><K><G><L><T><L><E><R><S><P><I><N><A><S><N><V><G><K><P><S><E><L><C><Q><S><F><E><C><M><V><G><L><T><L><K><R><N><P><M><S><V><S><N><D><G><K><P><S><D><L><P><H><T><F><E><Y><V><V><G><H><T><M><E><R><S><P><M><H><V><R><N><V><G><N><P><S><D><L><P><R><T><F><E><F><M><K><G><H><K><H><T>
May be involved in transcriptional regulation.<BOP>
Q8IYI8
Q8NEA9
GMCL2_HUMAN
Germ cell-less protein-like 1-like
Homo
<M><G><S><S><S><S><R><V><L><G><Q><P><R><R><A><L><A><Q><Q><E><Q><G><A><R><A><R><G><S><A><R><R><P><D><T><G><D><D><A><A><S><Y><G><F><C><Y><C><P><G><S><H><K><R><K><R><S><S><G><A><C><R><Y><C><D><P><D><S><H><R><E><E><H><E><E><E><G><D><K><Q><Q><P><L><L><N><T><P><A><R><K><K><L><R><S><T><S><K><Y><I><Y><Q><T><L><F><L><N><G><E><N><S><D><I><K><I><C><A><L><G><E><E><W><R><L><H><K><I><Y><L><C><Q><S><G><Y><F><S><S><M><F><S><G><S><W><K><E><S><S><M><N><I><I><E><L><E><I><P><D><Q><N><I><D><V><D><A><L><Q><V><A><F><G><S><L><Y><R><D><D><V><L><I><K><P><S><R><V><V><A><I><L><A><A><A><C><M><L><Q><L><D><G><L><I><Q><Q><C><G><E><T><M><K><E><T><I><N><V><K><T><V><C><G><Y><Y><T><S><V><E><I><Y><G><L><D><S><V><K><K><K><C><L><E><W><L><L><N><N><L><M><T><H><Q><N><V><K><L><F><K><E><L><G><I><N><V><M><K><Q><L><I><G><S><S><N><L><F><V><M><Q><V><E><M><D><V><Y><T><T><L><K><K><W><M><F><L><Q><L><V><P><S><W><N><G><S><L><K><Q><L><L><T><E><T><D><V><W><F><S><K><Q><R><K><D><F><E><G><M><A><F><L><E><T><E><P><G><K><P><F><V><S><V><F><R><H><L><R><L><Q><Y><I><I><S><D><L><A><S><A><R><I><I><E><Q><D><G><I><V><P><S><E><W><L><S><S><V><Y><K><Q><Q><W><F><A><M><L><R><A><E><Q><D><R><E><V><G><P><Q><E><I><N><K><E><D><L><E><G><N><S><M><R><C><G><R><K><L><A><K><D><G><E><Y><Y><W><C><W><T><G><F><N><F><G><F><D><L><L><V><I><Y><T><N><G><Y><I><I><F><K><R><N><T><L><N><Q><P><R><S><G><S><V><S><L><R><P><R><R><S><I><A><F><R><L><R><L><A><S><F><D><S><S><G><K><L><V><C><S><R><T><T><G><Y><Q><I><L><I><L><K><K><D><Q><E><Q><V><V><M><N><L><D><S><R><F><L><T><F><P><L><Y><I><C><C><N><F><L><Y><I><S><P><E><K><G><I><E><N><N><R><H><P><E><N><P><E><N>
Possible function in spermatogenesis. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins .<BOP>
Q8NEA9
P22033
MUTA_HUMAN
Methylmalonyl-CoA isomerase
Homo
<M><L><R><A><K><N><Q><L><F><L><L><S><P><H><Y><L><R><Q><V><K><E><S><S><G><S><R><L><I><Q><Q><R><L><L><H><Q><Q><Q><P><L><H><P><E><W><A><A><L><A><K><K><Q><L><K><G><K><N><P><E><D><L><I><W><H><T><P><E><G><I><S><I><K><P><L><Y><S><K><R><D><T><M><D><L><P><E><E><L><P><G><V><K><P><F><T><R><G><P><Y><P><T><M><Y><T><F><R><P><W><T><I><R><Q><Y><A><G><F><S><T><V><E><E><S><N><K><F><Y><K><D><N><I><K><A><G><Q><Q><G><L><S><V><A><F><D><L><A><T><H><R><G><Y><D><S><D><N><P><R><V><R><G><D><V><G><M><A><G><V><A><I><D><T><V><E><D><T><K><I><L><F><D><G><I><P><L><E><K><M><S><V><S><M><T><M><N><G><A><V><I><P><V><L><A><N><F><I><V><T><G><E><E><Q><G><V><P><K><E><K><L><T><G><T><I><Q><N><D><I><L><K><E><F><M><V><R><N><T><Y><I><F><P><P><E><P><S><M><K><I><I><A><D><I><F><E><Y><T><A><K><H><M><P><K><F><N><S><I><S><I><S><G><Y><H><M><Q><E><A><G><A><D><A><I><L><E><L><A><Y><T><L><A><D><G><L><E><Y><S><R><T><G><L><Q><A><G><L><T><I><D><E><F><A><P><R><L><S><F><F><W><G><I><G><M><N><F><Y><M><E><I><A><K><M><R><A><G><R><R><L><W><A><H><L><I><E><K><M><F><Q><P><K><N><S><K><S><L><L><L><R><A><H><C><Q><T><S><G><W><S><L><T><E><Q><D><P><Y><N><N><I><V><R><T><A><I><E><A><M><A><A><V><F><G><G><T><Q><S><L><H><T><N><S><F><D><E><A><L><G><L><P><T><V><K><S><A><R><I><A><R><N><T><Q><I><I><I><Q><E><E><S><G><I><P><K><V><A><D><P><W><G><G><S><Y><M><M><E><C><L><T><N><D><V><Y><D><A><A><L><K><L><I><N><E><I><E><E><M><G><G><M><A><K><A><V><A><E><G><I><P><K><L><R><I><E><E><C><A><A><R><R><Q><A><R><I><D><S><G><S><E><V><I><V><G><V><N><K><Y><Q><L><E><K><E><D><A><V><E><V><L><A><I><D><N><T><S><V><R><N><R><Q><I><E><K><L><K><K><I><K><S><S><R><D><Q><A><L><A><E><R><C><L><A><A><L><T><E><C><A><A><S><G><D><G><N><I><L><A><L><A><V><D><A><S><R><A><R><C><T><V><G><E><I><T><D><A><L><K><K><V><F><G><E><H><K><A><N><D><R><M><V><S><G><A><Y><R><Q><E><F><G><E><S><K><E><I><T><S><A><I><K><R><V><H><K><F><M><E><R><E><G><R><R><P><R><L><L><V><A><K><M><G><Q><D><G><H><D><R><G><A><K><V><I><A><T><G><F><A><D><L><G><F><D><V><D><I><G><P><L><F><Q><T><P><R><E><V><A><Q><Q><A><V><D><A><D><V><H><A><V><G><I><S><T><L><A><A><G><H><K><T><L><V><P><E><L><I><K><E><L><N><S><L><G><R><P><D><I><L><V><M><C><G><G><V><I><P><P><Q><D><Y><E><F><L><F><E><V><G><V><S><N><V><F><G><P><G><T><R><I><P><K><A><A><V><Q><V><L><D><D><I><E><K><C><L><E><K><K><Q><Q><S><V>
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.<BOP>
P22033
Q9HBY0
NOX3_HUMAN
gp91phox homolog 3
Homo
<M><M><G><C><W><I><L><N><E><G><L><S><T><I><L><V><L><S><W><L><G><I><N><F><Y><L><F><I><D><T><F><Y><W><Y><E><E><E><E><S><F><H><Y><T><R><V><I><L><G><S><T><L><A><W><A><R><A><S><A><L><C><L><N><F><N><C><M><L><I><L><I><P><V><S><R><N><L><I><S><F><I><R><G><T><S><I><C><C><R><G><P><W><R><R><Q><L><D><K><N><L><R><F><H><K><L><V><A><Y><G><I><A><V><N><A><T><I><H><I><V><A><H><F><F><N><L><E><R><Y><H><W><S><Q><S><E><E><A><Q><G><L><L><A><A><L><S><K><L><G><N><T><P><N><E><S><Y><L><N><P><V><R><T><F><P><T><N><T><T><T><E><L><L><R><T><I><A><G><V><T><G><L><V><I><S><L><A><L><V><L><I><M><T><S><S><T><E><F><I><R><Q><A><S><Y><E><L><F><W><Y><T><H><H><V><F><I><V><F><F><L><S><L><A><I><H><G><T><G><R><I><V><R><G><Q><T><Q><D><S><L><S><L><H><N><I><T><F><C><R><D><R><Y><A><E><W><Q><T><V><A><Q><C><P><V><P><Q><F><S><G><K><E><P><S><A><W><K><W><I><L><G><P><V><V><L><Y><A><C><E><R><I><I><R><F><W><R><F><Q><Q><E><V><V><I><T><K><V><V><S><H><P><S><G><V><L><E><L><H><M><K><K><R><G><F><K><M><A><P><G><Q><Y><I><L><V><Q><C><P><A><I><S><S><L><E><W><H><P><F><T><L><T><S><A><P><Q><E><D><F><F><S><V><H><I><R><A><A><G><D><W><T><A><A><L><L><E><A><F><G><A><E><G><Q><A><L><Q><E><P><W><S><L><P><R><L><A><V><D><G><P><F><G><T><A><L><T><D><V><F><H><Y><P><V><C><V><C><V><A><A><G><I><G><V><T><P><F><A><A><L><L><K><S><I><W><Y><K><C><S><E><A><Q><T><P><L><K><L><S><K><V><Y><F><Y><W><I><C><R><D><A><R><A><F><E><W><F><A><D><L><L><L><S><L><E><T><R><M><S><E><Q><G><K><T><H><F><L><S><Y><H><I><F><L><T><G><W><D><E><N><Q><A><L><H><I><A><L><H><W><D><E><N><T><D><V><I><T><G><L><K><Q><K><T><F><Y><G><R><P><N><W><N><N><E><F><K><Q><I><A><Y><N><H><P><S><S><S><I><G><V><F><F><C><G><P><K><A><L><S><R><T><L><Q><K><M><C><H><L><Y><S><S><A><D><P><R><G><V><H><F><Y><Y><N><K><E><S><F>
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.<BOP>
Q9HBY0
Q9BUN1
MENT_HUMAN
Methylated in normal thymocytes protein
Homo
<M><V><P><A><A><G><A><L><L><W><V><L><L><L><N><L><G><P><R><A><A><G><A><Q><G><L><T><Q><T><P><T><E><M><Q><R><V><S><L><R><F><G><G><P><M><T><R><S><Y><R><S><T><A><R><T><G><L><P><R><K><T><R><I><I><L><E><D><E><N><D><A><M><A><D><A><D><R><L><A><G><P><A><A><A><E><L><L><A><A><T><V><S><T><G><F><S><R><S><S><A><I><N><E><E><D><G><S><S><E><E><G><V><V><I><N><A><G><K><D><S><T><S><R><E><L><P><S><A><T><P><N><T><A><G><S><S><S><T><R><F><I><A><N><S><Q><E><P><E><I><R><L><T><S><S><L><P><R><S><P><G><R><S><T><E><D><L><P><G><S><Q><A><T><L><S><Q><W><S><T><P><G><S><T><P><S><R><W><P><S><P><S><P><T><A><M><P><S><P><E><D><L><R><L><V><L><M><P><W><G><P><W><H><C><H><C><K><S><G><T><M><S><R><S><R><S><G><K><L><H><G><L><S><G><R><L><R><V><G><A><L><S><Q><L><R><T><E><H><K><P><C><T><Y><Q><Q><C><P><C><N><R><L><R><E><E><C><P><L><D><T><S><L><C><T><D><T><N><C><A><S><Q><S><T><T><S><T><R><T><T><T><T><P><F><P><T><I><H><L><R><S><S><P><S><L><P><P><A><S><P><C><P><A><L><A><F><W><K><R><V><R><I><G><L><E><D><I><W><N><S><L><S><S><V><F><T><E><M><Q><P><I><D><R><N><Q><R>
Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.<BOP>
Q9BUN1
P58317
ZN121_HUMAN
Zinc finger protein 20
Homo
<M><A><E><I><H><N><G><G><E><L><C><D><F><M><E><N><G><E><I><F><S><E><H><S><C><L><N><A><H><M><G><T><E><N><T><G><D><T><Y><D><C><D><E><Y><G><E><N><F><P><M><L><H><N><S><A><P><A><G><E><T><L><S><V><L><N><Q><C><R><K><A><F><S><L><P><P><N><V><H><Q><R><T><W><I><G><D><K><S><F><E><Y><S><D><C><E><E><A><F><V><D><Q><S><H><L><Q><A><N><R><I><T><H><N><G><E><T><L><Y><E><Q><K><Q><C><G><R><A><F><T><Y><S><T><S><H><A><V><S><V><K><M><H><T><V><E><K><P><Y><E><C><K><E><C><G><K><F><F><R><Y><S><S><Y><L><N><S><H><M><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><C><F><T><V><S><S><H><L><V><E><H><V><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><R><A><F><A><G><R><S><G><L><T><K><H><V><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><Y><N><R><F><Y><L><L><T><E><H><F><K><T><H><T><E><E><K><P><F><E><C><K><V><C><G><K><S><F><R><S><S><S><C><L><K><N><H><F><R><I><H><T><G><I><K><P><Y><K><C><K><E><C><G><K><A><F><T><V><S><S><S><L><H><N><H><V><K><I><H><T><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><A><T><S><S><Q><L><I><E><H><I><R><T><H><T><G><E><K><P><Y><I><C><K><E><C><G><K><T><F><R><A><S><S><H><L><Q><K><H><V><R><I><H><T><G><E><K><P><Y><I><C><N><E><C><G><K><A><Y><N><R><F><Y><L><L><T><K><H><L><K><T><H>
May be involved in transcriptional regulation.<BOP>
P58317
O00757
F16P2_HUMAN
Muscle FBPase
Homo
<M><T><D><R><S><P><F><E><T><D><M><L><T><L><T><R><Y><V><M><E><K><G><R><Q><A><K><G><T><G><E><L><T><Q><L><L><N><S><M><L><T><A><I><K><A><I><S><S><A><V><R><K><A><G><L><A><H><L><Y><G><I><A><G><S><V><N><V><T><G><D><E><V><K><K><L><D><V><L><S><N><S><L><V><I><N><M><V><Q><S><S><Y><S><T><C><V><L><V><S><E><E><N><K><D><A><I><I><T><A><K><E><K><R><G><K><Y><V><V><C><F><D><P><L><D><G><S><S><N><I><D><C><L><A><S><I><G><T><I><F><A><I><Y><R><K><T><S><E><D><E><P><S><E><K><D><A><L><Q><C><G><R><N><I><V><A><A><G><Y><A><L><Y><G><S><A><T><L><V><A><L><S><T><G><Q><G><V><D><L><F><M><L><D><P><A><L><G><E><F><V><L><V><E><K><D><V><K><I><K><K><K><G><K><I><Y><S><L><N><E><G><Y><A><K><Y><F><D><A><A><T><T><E><Y><V><Q><K><K><K><F><P><E><D><G><S><A><P><Y><G><A><R><Y><V><G><S><M><V><A><D><V><H><R><T><L><V><Y><G><G><I><F><L><Y><P><A><N><Q><K><S><P><K><G><K><L><R><L><L><Y><E><C><N><P><V><A><Y><I><I><E><Q><A><G><G><L><A><T><T><G><T><Q><P><V><L><D><V><K><P><E><A><I><H><Q><R><V><P><L><I><L><G><S><P><E><D><V><Q><E><Y><L><T><C><V><Q><K><N><Q><A><G><S>
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.<BOP>
O00757
Q96CW6
S7A6O_HUMAN
Solute carrier family 7 member 6 opposite strand transcript
Homo
<M><E><A><A><R><T><A><V><L><R><V><K><R><K><R><S><A><E><P><A><E><A><L><V><L><A><C><K><R><L><R><S><D><A><V><E><S><A><A><Q><K><T><S><E><G><L><E><R><A><A><E><N><N><V><F><H><L><V><A><T><V><C><S><Q><E><E><P><V><Q><P><L><L><R><E><V><L><R><P><S><R><D><S><Q><Q><R><V><R><R><N><L><R><A><S><A><R><E><V><R><Q><E><G><R><Y><R><V><L><S><S><R><R><S><L><G><T><T><S><S><G><Q><E><S><E><Y><T><P><G><N><P><E><A><A><G><N><S><G><F><Q><L><L><D><L><V><H><E><E><G><E><P><E><A><A><S><A><G><S><C><K><T><S><D><P><D><V><I><L><C><N><S><V><E><L><I><R><E><R><L><T><V><S><E><D><G><P><G><V><R><R><Q><E><E><Q><K><H><D><D><Y><V><Y><D><I><Y><Y><L><E><T><A><T><P><G><W><I><E><N><I><L><S><V><Q><P><Y><S><Q><E><W><E><L><V><N><D><D><Q><E><P><E><D><I><Y><D><D><E><D><D><E><N><S><E><N><N><W><R><N><E><Y><P><E><E><E><S><S><D><G><D><E><D><S><R><G><S><A><D><Y><N><S><L><S><E><E><E><R><G><S><S><R><Q><R><M><W><S><K><Y><P><L><D><V><Q><K><E><F><G><Y><D><S><P><H><D><L><D><S><D>
Directs RNA polymerase II nuclear import.<BOP>
Q96CW6
Q96AQ6
PBIP1_HUMAN
Hematopoietic PBX-interacting protein
Homo
<M><A><S><C><P><D><S><D><N><S><W><V><L><A><G><S><E><S><L><P><V><E><T><L><G><P><A><S><R><M><D><P><E><S><E><R><A><L><Q><A><P><H><S><P><S><K><T><D><G><K><E><L><A><G><T><M><D><G><E><G><T><L><F><Q><T><E><S><P><Q><S><G><S><I><L><T><E><E><T><E><V><K><G><T><L><E><G><D><V><C><G><V><E><P><P><G><P><G><D><T><V><V><Q><G><D><L><Q><E><T><T><V><V><T><G><L><G><P><D><T><Q><D><L><E><G><Q><S><P><P><Q><S><L><P><S><T><P><K><A><A><W><I><R><E><E><G><R><C><S><S><S><D><D><D><T><D><V><D><M><E><G><L><R><R><R><R><G><R><E><A><G><P><P><Q><P><M><V><P><L><A><V><E><N><Q><A><G><G><E><G><A><G><G><E><L><G><I><S><L><N><M><C><L><L><G><A><L><V><L><L><G><L><G><V><L><L><F><S><G><G><L><S><E><S><E><T><G><P><M><E><E><V><E><R><Q><V><L><P><D><P><E><V><L><E><A><V><G><D><R><Q><D><G><L><R><E><Q><L><Q><A><P><V><P><P><D><S><V><P><S><L><Q><N><M><G><L><L><L><D><K><L><A><K><E><N><Q><D><I><R><L><L><Q><A><Q><L><Q><A><Q><K><E><E><L><Q><S><L><M><H><Q><P><K><G><L><E><E><E><N><A><Q><L><R><G><A><L><Q><Q><G><E><A><F><Q><R><A><L><E><S><E><L><Q><Q><L><R><A><R><L><Q><G><L><E><A><D><C><V><R><G><P><D><G><V><C><L><S><G><G><R><G><P><Q><G><D><K><A><I><R><E><Q><G><P><R><E><Q><E><P><E><L><S><F><L><K><Q><K><E><Q><L><E><A><E><A><Q><A><L><R><Q><E><L><E><R><Q><R><R><L><L><G><S><V><Q><Q><D><L><E><R><S><L><Q><D><A><S><R><G><D><P><A><H><A><G><L><A><E><L><G><H><R><L><A><Q><K><L><Q><G><L><E><N><W><G><Q><D><P><G><V><S><A><N><A><S><K><A><W><H><Q><K><S><H><F><Q><N><S><R><E><W><S><G><K><E><K><W><W><D><G><Q><R><D><R><K><A><E><H><W><K><H><K><K><E><E><S><G><R><E><R><K><K><N><W><G><G><Q><E><D><R><E><P><A><G><R><W><K><E><G><R><P><R><V><E><E><S><G><S><K><K><E><G><K><R><Q><G><P><K><E><P><P><R><K><S><G><S><F><H><S><S><G><E><K><Q><K><Q><P><R><W><R><E><G><T><K><D><S><H><D><P><L><P><S><W><A><E><L><L><R><P><K><Y><R><A><P><Q><G><C><S><G><V><D><E><C><A><R><Q><E><G><L><T><F><F><G><T><E><L><A><P><V><R><Q><Q><E><L><A><S><L><L><R><T><Y><L><A><R><L><P><W><A><G><Q><L><T><K><E><L><P><L><S><P><A><F><F><G><E><D><G><I><F><R><H><D><R><L><R><F><R><D><F><V><D><A><L><E><D><S><L><E><E><V><A><V><Q><Q><T><G><D><D><D><E><V><D><D><F><E><D><F><I><F><S><H><F><F><G><D><K><A><L><K><K><R><S><G><K><K><D><K><H><S><Q><S><P><R><A><A><G><P><R><E><G><H><S><H><S><H><H><H><H><H><R><G>
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.<BOP>
Q96AQ6
Q9H2U2
IPYR2_HUMAN
Pyrophosphate phospho-hydrolase 2
Homo
<M><S><A><L><L><R><L><L><R><T><G><A><P><A><A><A><C><L><R><L><G><T><S><A><G><T><G><S><R><R><A><M><A><L><Y><H><T><E><E><R><G><Q><P><C><S><Q><N><Y><R><L><F><F><K><N><V><T><G><H><Y><I><S><P><F><H><D><I><P><L><K><V><N><S><K><E><E><N><G><I><P><M><K><K><A><R><N><D><E><Y><E><N><L><F><N><M><I><V><E><I><P><R><W><T><N><A><K><M><E><I><A><T><K><E><P><M><N><P><I><K><Q><Y><V><K><D><G><K><L><R><Y><V><A><N><I><F><P><Y><K><G><Y><I><W><N><Y><G><T><L><P><Q><T><W><E><D><P><H><E><K><D><K><S><T><N><C><F><G><D><N><D><P><I><D><V><C><E><I><G><S><K><I><L><S><C><G><E><V><I><H><V><K><I><L><G><I><L><A><L><I><D><E><G><E><T><D><W><K><L><I><A><I><N><A><N><D><P><E><A><S><K><F><H><D><I><D><D><V><K><K><F><K><P><G><Y><L><E><A><T><L><N><W><F><R><L><Y><K><V><P><D><G><K><P><E><N><Q><F><A><F><N><G><E><F><K><N><K><A><F><A><L><E><V><I><K><S><T><H><Q><C><W><K><A><L><L><M><K><K><C><N><G><G><A><I><N><C><T><N><V><Q><I><S><D><S><P><F><R><C><T><Q><E><E><A><R><S><L><V><E><S><V><S><S><S><P><N><K><E><S><N><E><E><E><Q><V><W><H><F><L><G><K>
Hydrolyzes inorganic pyrophosphate . This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function .<BOP>
Q9H2U2
Q96RI8
TAAR6_HUMAN
Trace amine receptor 4
Homo
<M><S><S><N><S><S><L><L><V><A><V><Q><L><C><Y><A><N><V><N><G><S><C><V><K><I><P><F><S><P><G><S><R><V><I><L><Y><I><V><F><G><F><G><A><V><L><A><V><F><G><N><L><L><V><M><I><S><I><L><H><F><K><Q><L><H><S><P><T><N><F><L><V><A><S><L><A><C><A><D><F><L><V><G><V><T><V><M><P><F><S><M><V><R><T><V><E><S><C><W><Y><F><G><R><S><F><C><T><F><H><T><C><C><D><V><A><F><C><Y><S><S><L><F><H><L><C><F><I><S><I><D><R><Y><I><A><V><T><D><P><L><V><Y><P><T><K><F><T><V><S><V><S><G><I><C><I><S><V><S><W><I><L><P><L><M><Y><S><G><A><V><F><Y><T><G><V><Y><D><D><G><L><E><E><L><S><D><A><L><N><C><I><G><G><C><Q><T><V><V><N><Q><N><W><V><L><T><D><F><L><S><F><F><I><P><T><F><I><M><I><I><L><Y><G><N><I><F><L><V><A><R><R><Q><A><K><K><I><E><N><T><G><S><K><T><E><S><S><S><E><S><Y><K><A><R><V><A><R><R><E><R><K><A><A><K><T><L><G><V><T><V><V><A><F><M><I><S><W><L><P><Y><S><I><D><S><L><I><D><A><F><M><G><F><I><T><P><A><C><I><Y><E><I><C><C><W><C><A><Y><Y><N><S><A><M><N><P><L><I><Y><A><L><F><Y><P><W><F><R><K><A><I><K><V><I><V><T><G><Q><V><L><K><N><S><S><A><T><M><N><L><F><S><E><H><I>
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.<BOP>
Q96RI8
Q8WWH5
TRUB1_HUMAN
tRNA pseudouridine 55 synthase TRUB1
Homo
<M><A><A><S><E><A><A><V><V><S><S><P><S><L><K><T><D><T><S><P><V><L><E><T><A><G><T><V><A><A><M><A><A><T><P><S><A><R><A><A><A><A><V><V><A><A><A><A><R><T><G><S><E><A><R><V><S><K><A><A><L><A><T><K><L><L><S><L><S><G><V><F><A><V><H><K><P><K><G><P><T><S><A><E><L><L><N><R><L><K><E><K><L><L><A><E><A><G><M><P><S><P><E><W><T><K><R><K><K><Q><T><L><K><I><G><H><G><G><T><L><D><S><A><A><R><G><V><L><V><V><G><I><G><S><G><T><K><M><L><T><S><M><L><S><G><S><K><R><Y><T><A><I><G><E><L><G><K><A><T><D><T><L><D><S><T><G><R><V><T><E><E><K><P><Y><D><K><I><T><Q><E><D><I><E><G><I><L><Q><K><F><T><G><N><I><M><Q><V><P><P><L><Y><S><A><L><K><K><D><G><Q><R><L><S><T><L><M><K><R><G><E><V><V><E><A><K><P><A><R><P><V><T><V><Y><S><I><S><L><Q><K><F><Q><P><P><F><F><T><L><D><V><E><C><G><G><G><F><Y><I><R><S><L><V><S><D><I><G><K><E><L><S><S><C><A><N><V><L><E><L><T><R><T><K><Q><G><P><F><T><L><E><E><H><A><L><P><E><D><K><W><T><I><D><D><I><A><Q><S><L><E><H><C><S><S><L><F><P><A><E><L><A><L><K><K><S><K><P><E><S><N><E><Q><V><L><S><C><E><Y><I><T><L><N><E><P><K><R><E><D><D><V><I><K><T><C>
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs . Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure . Constitutes the major pseudouridine synthase acting on mRNAs . Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs . Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity . Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation .<BOP>
Q8WWH5
P20151
KLK2_HUMAN
Tissue kallikrein-2
Homo
<M><W><D><L><V><L><S><I><A><L><S><V><G><C><T><G><A><V><P><L><I><Q><S><R><I><V><G><G><W><E><C><E><K><H><S><Q><P><W><Q><V><A><V><Y><S><H><G><W><A><H><C><G><G><V><L><V><H><P><Q><W><V><L><T><A><A><H><C><L><K><K><N><S><Q><V><W><L><G><R><H><N><L><F><E><P><E><D><T><G><Q><R><V><P><V><S><H><S><F><P><H><P><L><Y><N><M><S><L><L><K><H><Q><S><L><R><P><D><E><D><S><S><H><D><L><M><L><L><R><L><S><E><P><A><K><I><T><D><V><V><K><V><L><G><L><P><T><Q><E><P><A><L><G><T><T><C><Y><A><S><G><W><G><S><I><E><P><E><E><F><L><R><P><R><S><L><Q><C><V><S><L><H><L><L><S><N><D><M><C><A><R><A><Y><S><E><K><V><T><E><F><M><L><C><A><G><L><W><T><G><G><K><D><T><C><G><G><D><S><G><G><P><L><V><C><N><G><V><L><Q><G><I><T><S><W><G><P><E><P><C><A><L><P><E><K><P><A><V><Y><T><K><V><V><H><Y><R><K><W><I><K><D><T><I><A><A><N><P>
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.<BOP>
P20151
P54922
ADPRH_HUMAN
[Protein ADP-ribosylarginine] hydrolase
Homo
<M><E><K><Y><V><A><A><M><V><L><S><A><A><G><D><A><L><G><Y><Y><N><G><K><W><E><F><L><Q><D><G><E><K><I><H><R><Q><L><A><Q><L><G><G><L><D><A><L><D><V><G><R><W><R><V><S><D><D><T><V><M><H><L><A><T><A><E><A><L><V><E><A><G><K><A><P><K><L><T><Q><L><Y><Y><L><L><A><K><H><Y><Q><D><C><M><E><D><M><D><G><R><A><P><G><G><A><S><V><H><N><A><M><Q><L><K><P><G><K><P><N><G><W><R><I><P><F><N><S><H><E><G><G><C><G><A><A><M><R><A><M><C><I><G><L><R><F><P><H><H><S><Q><L><D><T><L><I><Q><V><S><I><E><S><G><R><M><T><H><H><H><P><T><G><Y><L><G><A><L><A><S><A><L><F><T><A><Y><A><V><N><S><R><P><P><L><Q><W><G><K><G><L><M><E><L><L><P><E><A><K><K><Y><I><V><Q><S><G><Y><F><V><E><E><N><L><Q><H><W><S><Y><F><Q><T><K><W><E><N><Y><L><K><L><R><G><I><L><D><G><E><S><A><P><T><F><P><E><S><F><G><V><K><E><R><D><Q><F><Y><T><S><L><S><Y><S><G><W><G><G><S><S><G><H><D><A><P><M><I><A><Y><D><A><V><L><A><A><G><D><S><W><K><E><L><A><H><R><A><F><F><H><G><G><D><S><D><S><T><A><A><I><A><G><C><W><W><G><V><M><Y><G><F><K><G><V><S><P><S><N><Y><E><K><L><E><Y><R><N><R><L><E><E><T><A><R><A><L><Y><S><L><G><S><K><E><D><T><V><I><S><L>
Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.<BOP>
P54922
P59190
RAB15_HUMAN
Ras-related protein Rab-15
Homo
<M><A><K><Q><Y><D><V><L><F><R><L><L><L><I><G><D><S><G><V><G><K><T><C><L><L><C><R><F><T><D><N><E><F><H><S><S><H><I><S><T><I><G><V><D><F><K><M><K><T><I><E><V><D><G><I><K><V><R><I><Q><I><W><D><T><A><G><Q><E><R><Y><Q><T><I><T><K><Q><Y><Y><R><R><A><Q><G><I><F><L><V><Y><D><I><S><S><E><R><S><Y><Q><H><I><M><K><W><V><S><D><V><D><E><Y><A><P><E><G><V><Q><K><I><L><I><G><N><K><A><D><E><E><Q><K><R><Q><V><G><R><E><Q><G><Q><Q><L><A><K><E><Y><G><M><D><F><Y><E><T><S><A><C><T><N><L><N><I><K><E><S><F><T><R><L><T><E><L><V><L><Q><A><H><R><K><E><L><E><G><L><R><M><R><A><S><N><E><L><A><L><A><E><L><E><E><E><E><G><K><P><E><G><P><A><N><S><S><K><T><C><W><C>
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.<BOP>
P59190
P20309
ACM3_HUMAN
Muscarinic acetylcholine receptor M3
Homo
<M><T><L><H><N><N><S><T><T><S><P><L><F><P><N><I><S><S><S><W><I><H><S><P><S><D><A><G><L><P><P><G><T><V><T><H><F><G><S><Y><N><V><S><R><A><A><G><N><F><S><S><P><D><G><T><T><D><D><P><L><G><G><H><T><V><W><Q><V><V><F><I><A><F><L><T><G><I><L><A><L><V><T><I><I><G><N><I><L><V><I><V><S><F><K><V><N><K><Q><L><K><T><V><N><N><Y><F><L><L><S><L><A><C><A><D><L><I><I><G><V><I><S><M><N><L><F><T><T><Y><I><I><M><N><R><W><A><L><G><N><L><A><C><D><L><W><L><A><I><D><Y><V><A><S><N><A><S><V><M><N><L><L><V><I><S><F><D><R><Y><F><S><I><T><R><P><L><T><Y><R><A><K><R><T><T><K><R><A><G><V><M><I><G><L><A><W><V><I><S><F><V><L><W><A><P><A><I><L><F><W><Q><Y><F><V><G><K><R><T><V><P><P><G><E><C><F><I><Q><F><L><S><E><P><T><I><T><F><G><T><A><I><A><A><F><Y><M><P><V><T><I><M><T><I><L><Y><W><R><I><Y><K><E><T><E><K><R><T><K><E><L><A><G><L><Q><A><S><G><T><E><A><E><T><E><N><F><V><H><P><T><G><S><S><R><S><C><S><S><Y><E><L><Q><Q><Q><S><M><K><R><S><N><R><R><K><Y><G><R><C><H><F><W><F><T><T><K><S><W><K><P><S><S><E><Q><M><D><Q><D><H><S><S><S><D><S><W><N><N><N><D><A><A><A><S><L><E><N><S><A><S><S><D><E><E><D><I><G><S><E><T><R><A><I><Y><S><I><V><L><K><L><P><G><H><S><T><I><L><N><S><T><K><L><P><S><S><D><N><L><Q><V><P><E><E><E><L><G><M><V><D><L><E><R><K><A><D><K><L><Q><A><Q><K><S><V><D><D><G><G><S><F><P><K><S><F><S><K><L><P><I><Q><L><E><S><A><V><D><T><A><K><T><S><D><V><N><S><S><V><G><K><S><T><A><T><L><P><L><S><F><K><E><A><T><L><A><K><R><F><A><L><K><T><R><S><Q><I><T><K><R><K><R><M><S><L><V><K><E><K><K><A><A><Q><T><L><S><A><I><L><L><A><F><I><I><T><W><T><P><Y><N><I><M><V><L><V><N><T><F><C><D><S><C><I><P><K><T><F><W><N><L><G><Y><W><L><C><Y><I><N><S><T><V><N><P><V><C><Y><A><L><C><N><K><T><F><R><T><T><F><K><M><L><L><L><C><Q><C><D><K><K><K><R><R><K><Q><Q><Y><Q><Q><R><Q><S><V><I><F><H><K><R><A><P><E><Q><A><L>
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.<BOP>
P20309
Q9BX67
JAM3_HUMAN
Soluble form of JAM-C
Homo
<M><A><L><R><R><P><P><R><L><R><L><C><A><R><L><P><D><F><F><L><L><L><L><F><R><G><C><L><I><G><A><V><N><L><K><S><S><N><R><T><P><V><V><Q><E><F><E><S><V><E><L><S><C><I><I><T><D><S><Q><T><S><D><P><R><I><E><W><K><K><I><Q><D><E><Q><T><T><Y><V><F><F><D><N><K><I><Q><G><D><L><A><G><R><A><E><I><L><G><K><T><S><L><K><I><W><N><V><T><R><R><D><S><A><L><Y><R><C><E><V><V><A><R><N><D><R><K><E><I><D><E><I><V><I><E><L><T><V><Q><V><K><P><V><T><P><V><C><R><V><P><K><A><V><P><V><G><K><M><A><T><L><H><C><Q><E><S><E><G><H><P><R><P><H><Y><S><W><Y><R><N><D><V><P><L><P><T><D><S><R><A><N><P><R><F><R><N><S><S><F><H><L><N><S><E><T><G><T><L><V><F><T><A><V><H><K><D><D><S><G><Q><Y><Y><C><I><A><S><N><D><A><G><S><A><R><C><E><E><Q><E><M><E><V><Y><D><L><N><I><G><G><I><I><G><G><V><L><V><V><L><A><V><L><A><L><I><T><L><G><I><C><C><A><Y><R><R><G><Y><F><I><N><N><K><Q><D><G><E><S><Y><K><N><P><G><K><P><D><G><V><N><Y><I><R><T><D><E><E><G><D><F><R><H><K><S><S><F><V><I>
Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.<BOP>
Q9BX67
A0A075B6J9
LV218_HUMAN
Immunoglobulin lambda variable 2-18
Homo
<M><A><W><A><L><L><L><L><T><L><L><T><Q><G><T><G><S><W><A><Q><S><A><L><T><Q><P><P><S><V><S><G><S><P><G><Q><S><V><T><I><S><C><T><G><T><S><S><D><V><G><S><Y><N><R><V><S><W><Y><Q><Q><P><P><G><T><A><P><K><L><M><I><Y><E><V><S><N><R><P><S><G><V><P><D><R><F><S><G><S><K><S><G><N><T><A><S><L><T><I><S><G><L><Q><A><E><D><E><A><D><Y><Y><C><S><L><Y><T><S><S><S><T><F>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A075B6J9
Q969N2
PIGT_HUMAN
Phosphatidylinositol-glycan biosynthesis class T protein
Homo
<M><A><A><A><M><P><L><A><L><L><V><L><L><L><L><G><P><G><G><W><C><L><A><E><P><P><R><D><S><L><R><E><E><L><V><I><T><P><L><P><S><G><D><V><A><A><T><F><Q><F><R><T><R><W><D><S><E><L><Q><R><E><G><V><S><H><Y><R><L><F><P><K><A><L><G><Q><L><I><S><K><Y><S><L><R><E><L><H><L><S><F><T><Q><G><F><W><R><T><R><Y><W><G><P><P><F><L><Q><A><P><S><G><A><E><L><W><V><W><F><Q><D><T><V><T><D><V><D><K><S><W><K><E><L><S><N><V><L><S><G><I><F><C><A><S><L><N><F><I><D><S><T><N><T><V><T><P><T><A><S><F><K><P><L><G><L><A><N><D><T><D><H><Y><F><L><R><Y><A><V><L><P><R><E><V><V><C><T><E><N><L><T><P><W><K><K><L><L><P><C><S><S><K><A><G><L><S><V><L><L><K><A><D><R><L><F><H><T><S><Y><H><S><Q><A><V><H><I><R><P><V><C><R><N><A><R><C><T><S><I><S><W><E><L><R><Q><T><L><S><V><V><F><D><A><F><I><T><G><Q><G><K><K><D><W><S><L><F><R><M><F><S><R><T><L><T><E><P><C><P><L><A><S><E><S><R><V><Y><V><D><I><T><T><Y><N><Q><D><N><E><T><L><E><V><H><P><P><P><T><T><T><Y><Q><D><V><I><L><G><T><R><K><T><Y><A><I><Y><D><L><L><D><T><A><M><I><N><N><S><R><N><L><N><I><Q><L><K><W><K><R><P><P><E><N><E><A><P><P><V><P><F><L><H><A><Q><R><Y><V><S><G><Y><G><L><Q><K><G><E><L><S><T><L><L><Y><N><T><H><P><Y><R><A><F><P><V><L><L><L><D><T><V><P><W><Y><L><R><L><Y><V><H><T><L><T><I><T><S><K><G><K><E><N><K><P><S><Y><I><H><Y><Q><P><A><Q><D><R><L><Q><P><H><L><L><E><M><L><I><Q><L><P><A><N><S><V><T><K><V><S><I><Q><F><E><R><A><L><L><K><W><T><E><Y><T><P><D><P><N><H><G><F><Y><V><S><P><S><V><L><S><A><L><V><P><S><M><V><A><A><K><P><V><D><W><E><E><S><P><L><F><N><S><L><F><P><V><S><D><G><S><N><Y><F><V><R><L><Y><T><E><P><L><L><V><N><L><P><T><P><D><F><S><M><P><Y><N><V><I><C><L><T><C><T><V><V><A><V><C><Y><G><S><F><Y><N><L><L><T><R><T><F><H><I><E><E><P><R><T><G><G><L><A><K><R><L><A><N><L><I><R><R><A><R><G><V><P><P><L>
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.<BOP>
Q969N2
P11474
ERR1_HUMAN
Nuclear receptor subfamily 3 group B member 1
Homo
<M><S><S><Q><V><V><G><I><E><P><L><Y><I><K><A><E><P><A><S><P><D><S><P><K><G><S><S><E><T><E><T><E><P><P><V><A><L><A><P><G><P><A><P><T><R><C><L><P><G><H><K><E><E><E><D><G><E><G><A><G><P><G><E><Q><G><G><G><K><L><V><L><S><S><L><P><K><R><L><C><L><V><C><G><D><V><A><S><G><Y><H><Y><G><V><A><S><C><E><A><C><K><A><F><F><K><R><T><I><Q><G><S><I><E><Y><S><C><P><A><S><N><E><C><E><I><T><K><R><R><R><K><A><C><Q><A><C><R><F><T><K><C><L><R><V><G><M><L><K><E><G><V><R><L><D><R><V><R><G><G><R><Q><K><Y><K><R><R><P><E><V><D><P><L><P><F><P><G><P><F><P><A><G><P><L><A><V><A><G><G><P><R><K><T><A><A><P><V><N><A><L><V><S><H><L><L><V><V><E><P><E><K><L><Y><A><M><P><D><P><A><G><P><D><G><H><L><P><A><V><A><T><L><C><D><L><F><D><R><E><I><V><V><T><I><S><W><A><K><S><I><P><G><F><S><S><L><S><L><S><D><Q><M><S><V><L><Q><S><V><W><M><E><V><L><V><L><G><V><A><Q><R><S><L><P><L><Q><D><E><L><A><F><A><E><D><L><V><L><D><E><E><G><A><R><A><A><G><L><G><E><L><G><A><A><L><L><Q><L><V><R><R><L><Q><A><L><R><L><E><R><E><E><Y><V><L><L><K><A><L><A><L><A><N><S><D><S><V><H><I><E><D><A><E><A><V><E><Q><L><R><E><A><L><H><E><A><L><L><E><Y><E><A><G><R><A><G><P><G><G><G><A><E><R><R><R><A><G><R><L><L><L><T><L><P><L><L><R><Q><T><A><G><K><V><L><A><H><F><Y><G><V><K><L><E><G><K><V><P><M><H><K><L><F><L><E><M><L><E><A><M><M><D>
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.<BOP>
P11474
P46778
RL21_HUMAN
Large ribosomal subunit protein eL21
Homo
<M><T><N><T><K><G><K><R><R><G><T><R><Y><M><F><S><R><P><F><R><K><H><G><V><V><P><L><A><T><Y><M><R><I><Y><K><K><G><D><I><V><D><I><K><G><M><G><T><V><Q><K><G><M><P><H><K><C><Y><H><G><K><T><G><R><V><Y><N><V><T><Q><H><A><V><G><I><V><V><N><K><Q><V><K><G><K><I><L><A><K><R><I><N><V><R><I><E><H><I><K><H><S><K><S><R><D><S><F><L><K><R><V><K><E><N><D><Q><K><K><K><E><A><K><E><K><G><T><W><V><Q><L><K><R><Q><P><A><P><P><R><E><A><H><F><V><R><T><N><G><K><E><P><E><L><L><E><P><I><P><Y><E><F><M><A>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP>
P46778
Q86XN8
MEX3D_HUMAN
TINO
Homo
<M><P><S><S><L><G><Q><P><D><G><G><G><G><G><G><G><G><G><G><G><V><G><A><A><G><E><D><P><G><P><G><P><A><P><P><P><E><G><A><Q><E><A><A><P><A><P><R><P><P><P><E><P><D><D><A><A><A><A><L><R><L><A><L><D><Q><L><S><A><L><G><L><G><G><A><G><D><T><D><E><E><G><A><A><G><D><G><A><A><A><A><G><G><A><D><G><G><A><A><P><E><P><V><P><P><D><G><P><E><A><G><A><P><P><T><L><A><P><A><V><A><P><G><S><L><P><L><L><D><P><N><A><S><P><P><P><P><P><P><P><R><P><S><P><P><D><V><F><A><G><F><A><P><H><P><A><A><L><G><P><P><T><L><L><A><D><Q><M><S><V><I><G><S><R><K><K><S><V><N><M><T><E><C><V><P><V><P><S><S><E><H><V><A><E><I><V><G><R><Q><G><C><K><I><K><A><L><R><A><K><T><N><T><Y><I><K><T><P><V><R><G><E><E><P><V><F><I><V><T><G><R><K><E><D><V><E><M><A><K><R><E><I><L><S><A><A><E><H><F><S><I><I><R><A><T><R><S><K><A><G><G><L><P><G><A><A><Q><G><P><P><N><L><P><G><Q><T><T><I><Q><V><R><V><P><Y><R><V><V><G><L><V><V><G><P><K><G><A><T><I><K><R><I><Q><Q><R><T><H><T><Y><I><V><T><P><G><R><D><K><E><P><V><F><A><V><T><G><M><P><E><N><V><D><R><A><R><E><E><I><E><A><H><I><T><L><R><T><G><A><F><T><D><A><G><P><D><S><D><F><H><A><N><G><T><D><V><C><L><D><L><L><G><A><A><A><S><L><W><A><K><T><P><N><Q><G><R><R><P><P><T><A><T><A><G><L><R><G><D><T><A><L><G><A><P><S><A><P><E><A><F><Y><A><G><S><R><G><G><P><S><V><P><D><P><G><P><A><S><P><Y><S><G><S><G><N><G><G><F><A><F><G><A><E><G><P><G><A><P><V><G><T><A><A><P><D><D><C><D><F><G><F><D><F><D><F><L><A><L><D><L><T><V><P><A><A><A><T><I><W><A><P><F><E><R><A><A><P><L><P><A><F><S><G><C><S><T><V><N><G><A><P><G><P><P><A><A><G><A><R><R><S><S><G><A><G><T><P><R><H><S><P><T><L><P><E><P><G><G><L><R><L><E><L><P><L><S><R><R><G><A><P><D><P><V><G><A><L><S><W><R><P><P><Q><G><P><V><S><F><P><G><G><A><A><F><S><T><A><T><S><L><P><S><S><P><A><A><A><A><C><A><P><L><D><S><G><A><S><E><N><S><R><K><P><P><S><A><S><S><A><P><A><L><A><R><E><C><V><V><C><A><E><G><E><V><M><A><A><L><V><P><C><G><H><N><L><F><C><M><D><C><A><V><R><I><C><G><K><S><E><P><E><C><P><A><C><R><T><P><A><T><Q><A><I><H><I><F><S>
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.<BOP>
Q86XN8
Q8WXX5
DNJC9_HUMAN
DnaJ protein SB73
Homo
<M><G><L><L><D><L><C><E><E><V><F><G><T><A><D><L><Y><R><V><L><G><V><R><R><E><A><S><D><G><E><V><R><R><G><Y><H><K><V><S><L><Q><V><H><P><D><R><V><G><E><G><D><K><E><D><A><T><R><R><F><Q><I><L><G><K><V><Y><S><V><L><S><D><R><E><Q><R><A><V><Y><D><E><Q><G><T><V><D><E><D><S><P><V><L><T><Q><D><R><D><W><E><A><Y><W><R><L><L><F><K><K><I><S><L><E><D><I><Q><A><F><E><K><T><Y><K><G><S><E><E><E><L><A><D><I><K><Q><A><Y><L><D><F><K><G><D><M><D><Q><I><M><E><S><V><L><C><V><Q><Y><T><E><E><P><R><I><R><N><I><I><Q><Q><A><I><D><A><G><E><V><P><S><Y><N><A><F><V><K><E><S><K><Q><K><M><N><A><R><K><R><R><A><Q><E><E><A><K><E><A><E><M><S><R><K><E><L><G><L><D><E><G><V><D><S><L><K><A><A><I><Q><S><R><Q><K><D><R><Q><K><E><M><D><N><F><L><A><Q><M><E><A><K><Y><C><K><S><S><K><G><G><G><K><K><S><A><L><K><K><E><K><K>
Acts as a dual histone chaperone and heat shock co-chaperone . As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes . May also act as a histone co-chaperone together with TONSL . May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers . Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 . As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity . Exhibits activity to assemble histones onto DNA in vitro .<BOP>
Q8WXX5
P46734
MP2K3_HUMAN
Stress-activated protein kinase kinase 2
Homo
<M><E><S><P><A><S><S><Q><P><A><S><M><P><Q><S><K><G><K><S><K><R><K><K><D><L><R><I><S><C><M><S><K><P><P><A><P><N><P><T><P><P><R><N><L><D><S><R><T><F><I><T><I><G><D><R><N><F><E><V><E><A><D><D><L><V><T><I><S><E><L><G><R><G><A><Y><G><V><V><E><K><V><R><H><A><Q><S><G><T><I><M><A><V><K><R><I><R><A><T><V><N><S><Q><E><Q><K><R><L><L><M><D><L><D><I><N><M><R><T><V><D><C><F><Y><T><V><T><F><Y><G><A><L><F><R><E><G><D><V><W><I><C><M><E><L><M><D><T><S><L><D><K><F><Y><R><K><V><L><D><K><N><M><T><I><P><E><D><I><L><G><E><I><A><V><S><I><V><R><A><L><E><H><L><H><S><K><L><S><V><I><H><R><D><V><K><P><S><N><V><L><I><N><K><E><G><H><V><K><M><C><D><F><G><I><S><G><Y><L><V><D><S><V><A><K><T><M><D><A><G><C><K><P><Y><M><A><P><E><R><I><N><P><E><L><N><Q><K><G><Y><N><V><K><S><D><V><W><S><L><G><I><T><M><I><E><M><A><I><L><R><F><P><Y><E><S><W><G><T><P><F><Q><Q><L><K><Q><V><V><E><E><P><S><P><Q><L><P><A><D><R><F><S><P><E><F><V><D><F><T><A><Q><C><L><R><K><N><P><A><E><R><M><S><Y><L><E><L><M><E><H><P><F><F><T><L><H><K><T><K><K><T><D><I><A><A><F><V><K><E><I><L><G><E><D><S>
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.<BOP>
P46734
Q99689
FEZ1_HUMAN
Zygin-1
Homo
<M><E><A><P><L><V><S><L><D><E><E><F><E><D><L><R><P><S><C><S><E><D><P><E><E><K><P><Q><C><F><Y><G><S><S><P><H><H><L><E><D><P><S><L><S><E><L><E><N><F><S><S><E><I><I><S><F><K><S><M><E><D><L><V><N><E><F><D><E><K><L><N><V><C><F><R><N><Y><N><A><K><T><E><N><L><A><P><V><K><N><Q><L><Q><I><Q><E><E><E><E><T><L><Q><D><E><E><V><W><D><A><L><T><D><N><Y><I><P><S><L><S><E><D><W><R><D><P><N><I><E><A><L><N><G><N><C><S><D><T><E><I><H><E><K><E><E><E><E><F><N><E><K><S><E><N><D><S><G><I><N><E><E><P><L><L><T><A><D><Q><V><I><E><E><I><E><E><M><M><Q><N><S><P><D><P><E><E><E><E><E><V><L><E><E><E><D><G><G><E><T><S><S><Q><A><D><S><V><L><L><Q><E><M><Q><A><L><T><Q><T><F><N><N><N><W><S><Y><E><G><L><R><H><M><S><G><S><E><L><T><E><L><L><D><Q><V><E><G><A><I><R><D><F><S><E><E><L><V><Q><Q><L><A><R><R><D><E><L><E><F><E><K><E><V><K><N><S><F><I><T><V><L><I><E><V><Q><N><K><Q><K><E><Q><R><E><L><M><K><K><R><R><K><E><K><G><L><S><L><Q><S><S><R><I><E><K><G><N><Q><M><P><L><K><R><F><S><M><E><G><I><S><N><I><L><Q><S><G><I><R><Q><T><F><G><S><S><G><T><D><K><Q><Y><L><N><T><V><I><P><Y><E><K><K><A><S><P><P><S><V><E><D><L><Q><M><L><T><N><I><L><F><A><M><K><E><D><N><E><K><V><P><T><L><L><T><D><Y><I><L><K><V><L><C><P><T>
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.<BOP>
Q99689
P17029
ZKSC1_HUMAN
Zinc finger protein KOX18
Homo
<M><M><T><A><E><S><R><E><A><T><G><L><S><P><Q><A><A><Q><E><K><D><G><I><V><I><V><K><V><E><E><E><D><E><E><D><H><M><W><G><Q><D><S><T><L><Q><D><T><P><P><P><D><P><E><I><F><R><Q><R><F><R><R><F><C><Y><Q><N><T><F><G><P><R><E><A><L><S><R><L><K><E><L><C><H><Q><W><L><R><P><E><I><N><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><S><I><L><P><K><E><L><Q><V><W><L><Q><E><Y><R><P><D><S><G><E><E><A><V><T><L><L><E><D><L><E><L><D><L><S><G><Q><Q><V><P><G><Q><V><H><G><P><E><M><L><A><R><G><M><V><P><L><D><P><V><Q><E><S><S><S><F><D><L><H><H><E><A><T><Q><S><H><F><K><H><S><S><R><K><P><R><L><L><Q><S><R><A><L><P><A><A><H><I><P><A><P><P><H><E><G><S><P><R><D><Q><A><M><A><S><A><L><F><T><A><D><S><Q><A><M><V><K><I><E><D><M><A><V><S><L><I><L><E><E><W><G><C><Q><N><L><A><R><R><N><L><S><R><D><N><R><Q><E><N><Y><G><S><A><F><P><Q><G><G><E><N><R><N><E><N><E><E><S><T><S><K><A><E><T><S><E><D><S><A><S><R><G><E><T><T><G><R><S><Q><K><E><F><G><E><K><R><D><Q><E><G><K><T><G><E><R><Q><Q><K><N><P><E><E><K><T><R><K><E><K><R><D><S><G><P><A><I><G><K><D><K><K><T><I><T><G><E><R><G><P><R><E><K><G><K><G><L><G><R><S><F><S><L><S><S><N><F><T><T><P><E><E><V><P><T><G><T><K><S><H><R><C><D><E><C><G><K><C><F><T><R><S><S><S><L><I><R><H><K><I><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><S><L><N><S><N><L><V><L><H><Q><R><I><H><T><G><E><K><P><H><E><C><N><E><C><G><K><A><F><S><H><S><S><N><L><I><L><H><Q><R><I><H><S><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><S><S><D><L><T><K><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><N><R><N><S><Y><L><I><L><H><R><R><I><H><T><R><E><K><P><Y><K><C><T><K><C><G><K><A><F><T><R><S><S><T><L><T><L><H><H><R><I><H><A><R><E><R><A><S><E><Y><S><P><A><S><L><D><A><F><G><A><F><L><K><S><C><V>
May be involved in transcriptional regulation.<BOP>
P17029
Q9UH36
SRR1L_HUMAN
SRR1 domain-containing protein
Homo
<M><A><A><A><A><A><A><A><L><E><S><W><Q><A><A><A><P><R><K><R><R><S><A><A><R><R><P><R><R><R><E><A><A><P><R><G><R><E><A><A><P><R><G><R><E><A><A><P><R><G><P><E><A><E><F><E><S><D><S><G><V><V><L><R><R><I><W><E><A><E><K><D><L><F><I><S><D><F><W><S><S><A><L><E><T><I><N><R><C><L><T><K><H><L><E><Q><L><K><A><P><V><G><T><L><S><D><I><F><G><N><L><H><L><D><S><L><P><E><E><S><D><V><A><T><D><S><I><P><R><E><I><L><V><T><G><T><C><H><L><K><C><V><C><Y><G><I><G><N><F><A><T><C><I><V><A><R><N><Q><L><T><F><L><L><L><L><L><E><K><C><Q><I><P><R><S><H><C><W><V><Y><D><P><L><F><S><Q><L><E><I><E><V><L><N><T><L><G><V><T><V><L><S><E><N><E><E><G><K><R><S><I><R><G><E><P><T><I><F><Y><M><L><H><C><G><T><A><L><Y><N><N><L><L><W><S><N><W><S><V><D><A><L><S><K><M><V><I><I><G><N><S><F><K><G><L><E><E><R><L><L><A><R><I><L><Q><K><N><Y><P><Y><I><A><K><I><L><K><G><L><E><E><L><E><F><P><Q><T><S><Q><Y><M><D><I><F><N><D><T><S><V><H><W><F><P><V><Q><K><L><E><Q><L><S><I><D><I><W><E><F><R><E><E><P><D><Y><Q><D><C><E><D><L><E><I><I><R><N><K><R><E><D><P><S><A><T><D>
Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes.<BOP>
Q9UH36
P48788
TNNI2_HUMAN
Troponin I, fast-twitch isoform
Homo
<M><G><D><E><E><K><R><N><R><A><I><T><A><R><R><Q><H><L><K><S><V><M><L><Q><I><A><A><T><E><L><E><K><E><E><S><R><R><E><A><E><K><Q><N><Y><L><A><E><H><C><P><P><L><H><I><P><G><S><M><S><E><V><Q><E><L><C><K><Q><L><H><A><K><I><D><A><A><E><E><E><K><Y><D><M><E><V><R><V><Q><K><T><S><K><E><L><E><D><M><N><Q><K><L><F><D><L><R><G><K><F><K><R><P><P><L><R><R><V><R><M><S><A><D><A><M><L><K><A><L><L><G><S><K><H><K><V><C><M><D><L><R><A><N><L><K><Q><V><K><K><E><D><T><E><K><E><R><D><L><R><D><V><G><D><W><R><K><N><I><E><E><K><S><G><M><E><G><R><K><K><M><F><E><S><E><S>
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP>
P48788
P0CJ77
HMN10_HUMAN
MT-RNR2-like protein 10
Homo
<M><T><T><R><G><F><S><C><L><L><L><L><I><R><E><I><D><L><S><A><K><R><R><I>
Plays a role as a neuroprotective and antiapoptotic factor.<BOP>
P0CJ77
Q6ICH7
ASPH2_HUMAN
Aspartate beta-hydroxylase domain-containing protein 2
Homo
<M><V><W><A><P><L><G><P><P><R><T><D><C><L><T><L><L><H><T><P><S><K><D><S><P><K><M><S><L><E><W><L><V><A><W><S><W><S><L><D><G><L><R><D><C><I><A><T><G><I><Q><S><V><R><D><C><D><T><T><A><V><I><T><V><A><C><L><L><V><L><F><V><W><Y><C><Y><H><V><G><R><E><Q><P><R><P><Y><V><S><V><N><S><L><M><Q><A><A><D><A><N><G><L><Q><N><G><Y><V><Y><C><Q><S><P><E><C><V><R><C><T><H><N><E><G><L><N><Q><K><L><Y><H><N><L><Q><E><Y><A><K><R><Y><S><W><S><G><M><G><R><I><H><K><G><I><R><E><Q><G><R><Y><L><N><S><R><P><S><I><Q><K><P><E><V><F><F><L><P><D><L><P><T><T><P><Y><F><S><R><D><A><Q><K><H><D><V><E><V><L><E><R><N><F><Q><T><I><L><C><E><F><E><T><L><Y><K><A><F><S><N><C><S><L><P><Q><G><W><K><M><N><S><T><P><S><G><E><W><F><T><F><Y><L><V><N><Q><G><V><C><V><P><R><N><C><R><K><C><P><R><T><Y><R><L><L><G><S><L><R><T><C><I><G><N><N><V><F><G><N><A><C><I><S><V><L><S><P><G><T><V><I><T><E><H><Y><G><P><T><N><I><R><I><R><C><H><L><G><L><K><T><P><N><G><C><E><L><V><V><G><G><E><P><Q><C><W><A><E><G><R><C><L><L><F><D><D><S><F><L><H><A><A><F><H><E><G><S><A><E><D><G><P><R><V><V><F><M><V><D><L><W><H><P><N><V><A><A><A><E><R><Q><A><L><D><F><I><F><A><P><G><R>
May function as 2-oxoglutarate-dependent dioxygenase.<BOP>
Q6ICH7
Q8TDF6
GRP4_HUMAN
RAS guanyl-releasing protein 4
Homo
<M><N><R><K><D><S><K><R><K><S><H><Q><E><C><T><G><K><I><G><G><R><G><R><P><R><Q><V><R><R><H><K><T><C><P><S><P><R><E><I><S><K><V><M><A><S><M><N><L><G><L><L><S><E><G><G><C><S><E><D><E><L><L><E><K><C><I><Q><S><F><D><S><A><G><S><L><C><H><E><D><H><M><L><N><M><V><L><A><M><H><S><W><V><L><P><S><A><D><L><A><A><R><L><L><T><S><Y><Q><K><A><T><G><D><T><Q><E><L><R><R><L><Q><I><C><H><L><V><R><Y><W><L><M><R><H><P><E><V><M><H><Q><D><P><Q><L><E><E><V><I><G><R><F><W><A><T><V><A><R><E><G><N><S><A><Q><R><R><L><G><D><S><S><D><L><L><S><P><G><G><P><G><P><P><L><P><M><S><S><P><G><L><G><K><K><R><K><V><S><L><L><F><D><H><L><E><T><G><E><L><A><Q><H><L><T><Y><L><E><F><R><S><F><Q><A><I><T><P><Q><D><L><R><S><Y><V><L><Q><G><S><V><R><G><C><P><A><L><E><G><S><V><G><L><S><N><S><V><S><R><W><V><Q><V><M><V><L><S><R><P><G><P><L><Q><R><A><Q><V><L><D><K><F><I><H><V><A><Q><R><L><H><Q><L><Q><N><F><N><T><L><M><A><V><T><G><G><L><C><H><S><A><I><S><R><L><K><D><S><H><A><H><L><S><P><D><S><T><K><A><L><L><E><L><T><E><L><L><A><S><H><N><N><Y><A><R><Y><R><R><T><W><A><G><C><A><G><F><R><L><P><V><L><G><V><H><L><K><D><L><V><S><L><H><E><A><Q><P><D><R><L><P><D><G><R><L><H><L><P><K><L><N><N><L><Y><L><R><L><Q><E><L><V><A><L><Q><G><Q><H><P><P><C><S><A><N><E><D><L><L><H><L><L><T><L><S><L><D><L><F><Y><T><E><D><E><I><Y><E><L><S><Y><A><R><E><P><R><C><P><K><S><L><P><P><S><P><F><N><A><P><L><V><V><E><W><A><P><G><V><T><P><K><P><D><R><V><T><L><G><R><H><V><E><Q><L><V><E><S><V><F><K><N><Y><D><P><E><G><R><G><T><I><S><Q><E><D><F><E><R><L><S><G><N><F><P><F><A><C><H><G><L><H><P><P><P><R><Q><G><R><G><S><F><S><R><E><E><L><T><G><Y><L><L><R><A><S><A><I><C><S><K><L><G><L><A><F><L><H><T><F><H><E><V><T><F><R><K><P><T><F><C><D><S><C><S><G><F><L><W><G><V><T><K><Q><G><Y><R><C><R><E><C><G><L><C><C><H><K><H><C><R><D><Q><V><K><V><E><C><K><K><R><P><G><A><K><G><D><A><G><P><P><G><A><P><V><P><S><T><P><A><P><H><A><S><C><G><S><E><E><N><H><S><Y><T><L><S><L><E><P><E><T><G><C><Q><L><R><H><A><W><T><Q><T><E><S><P><H><P><S><W><E><T><D><T><V><P><C><P><V><M><D><P><P><S><T><A><S><S><K><L><D><S>
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.<BOP>
Q8TDF6
P50749
RASF2_HUMAN
Ras association domain-containing protein 2
Homo
<M><D><Y><S><H><Q><T><S><L><V><P><C><G><Q><D><K><Y><I><S><K><N><E><L><L><L><H><L><K><T><Y><N><L><Y><Y><E><G><Q><N><L><Q><L><R><H><R><E><E><E><D><E><F><I><V><E><G><L><L><N><I><S><W><G><L><R><R><P><I><R><L><Q><M><Q><D><D><N><E><R><I><R><P><P><P><S><S><S><S><W><H><S><G><C><N><L><G><A><Q><G><T><T><L><K><P><L><T><V><P><K><V><Q><I><S><E><V><D><A><P><P><E><G><D><Q><M><P><S><S><T><D><S><R><G><L><K><P><L><Q><E><D><T><P><Q><L><M><R><T><R><S><D><V><G><V><R><R><R><G><N><V><R><T><P><S><D><Q><R><R><I><R><R><H><R><F><S><I><N><G><H><F><Y><N><H><K><T><S><V><F><T><P><A><Y><G><S><V><T><N><V><R><I><N><S><T><M><T><T><P><Q><V><L><K><L><L><L><N><K><F><K><I><E><N><S><A><E><E><F><A><L><Y><V><V><H><T><S><G><E><K><Q><K><L><K><A><T><D><Y><P><L><I><A><R><I><L><Q><G><P><C><E><Q><I><S><K><V><F><L><M><E><K><D><Q><V><E><E><V><T><Y><D><V><A><Q><Y><I><K><F><E><M><P><V><L><K><S><F><I><Q><K><L><Q><E><E><E><D><R><E><V><K><K><L><M><R><K><Y><T><V><L><R><L><M><I><R><Q><R><L><E><E><I><A><E><T><P><A><T><I>
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.<BOP>
P50749
P01011
AACT_HUMAN
Alpha-1-antichymotrypsin His-Pro-less
Homo
<M><E><R><M><L><P><L><L><A><L><G><L><L><A><A><G><F><C><P><A><V><L><C><H><P><N><S><P><L><D><E><E><N><L><T><Q><E><N><Q><D><R><G><T><H><V><D><L><G><L><A><S><A><N><V><D><F><A><F><S><L><Y><K><Q><L><V><L><K><A><P><D><K><N><V><I><F><S><P><L><S><I><S><T><A><L><A><F><L><S><L><G><A><H><N><T><T><L><T><E><I><L><K><G><L><K><F><N><L><T><E><T><S><E><A><E><I><H><Q><S><F><Q><H><L><L><R><T><L><N><Q><S><S><D><E><L><Q><L><S><M><G><N><A><M><F><V><K><E><Q><L><S><L><L><D><R><F><T><E><D><A><K><R><L><Y><G><S><E><A><F><A><T><D><F><Q><D><S><A><A><A><K><K><L><I><N><D><Y><V><K><N><G><T><R><G><K><I><T><D><L><I><K><D><L><D><S><Q><T><M><M><V><L><V><N><Y><I><F><F><K><A><K><W><E><M><P><F><D><P><Q><D><T><H><Q><S><R><F><Y><L><S><K><K><K><W><V><M><V><P><M><M><S><L><H><H><L><T><I><P><Y><F><R><D><E><E><L><S><C><T><V><V><E><L><K><Y><T><G><N><A><S><A><L><F><I><L><P><D><Q><D><K><M><E><E><V><E><A><M><L><L><P><E><T><L><K><R><W><R><D><S><L><E><F><R><E><I><G><E><L><Y><L><P><K><F><S><I><S><R><D><Y><N><L><N><D><I><L><L><Q><L><G><I><E><E><A><F><T><S><K><A><D><L><S><G><I><T><G><A><R><N><L><A><V><S><Q><V><V><H><K><A><V><L><D><V><F><E><E><G><T><E><A><S><A><A><T><A><V><K><I><T><L><L><S><A><L><V><E><T><R><T><I><V><R><F><N><R><P><F><L><M><I><I><V><P><T><D><T><Q><N><I><F><F><M><S><K><V><T><N><P><K><Q><A>
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.<BOP>
P01011
O75208
COQ9_HUMAN
Ubiquinone biosynthesis protein COQ9, mitochondrial
Homo
<M><A><A><A><A><V><S><G><A><L><G><R><A><G><W><R><L><L><Q><L><R><C><L><P><V><A><R><C><R><Q><A><L><V><P><R><A><F><H><A><S><A><V><G><L><R><S><S><D><E><Q><K><Q><Q><P><P><N><S><F><S><Q><Q><H><S><E><T><Q><G><A><E><K><P><D><P><E><S><S><H><S><P><P><R><Y><T><D><Q><G><G><E><E><E><E><D><Y><E><S><E><E><Q><L><Q><H><R><I><L><T><A><A><L><E><F><V><P><A><H><G><W><T><A><E><A><I><A><E><G><A><Q><S><L><G><L><S><S><A><A><A><S><M><F><G><K><D><G><S><E><L><I><L><H><F><V><T><Q><C><N><T><R><L><T><R><V><L><E><E><E><Q><K><L><V><Q><L><G><Q><A><E><K><R><K><T><D><Q><F><L><R><D><A><V><E><T><R><L><R><M><L><I><P><Y><I><E><H><W><P><R><A><L><S><I><L><M><L><P><H><N><I><P><S><S><L><S><L><L><T><S><M><V><D><D><M><W><H><Y><A><G><D><Q><S><T><D><F><N><W><Y><T><R><R><A><M><L><A><A><I><Y><N><T><T><E><L><V><M><M><Q><D><S><S><P><D><F><E><D><T><W><R><F><L><E><N><R><V><N><D><A><M><N><M><G><H><T><A><K><Q><V><K><S><T><G><E><A><L><V><Q><G><L><M><G><A><A><V><T><L><K><N><L><T><G><L><N><Q><R><R>
Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.<BOP>
O75208
Q6V0L0
CP26C_HUMAN
Cytochrome P450 26C1
Homo
<M><F><P><W><G><L><S><C><L><S><V><L><G><A><A><G><T><A><L><L><C><A><G><L><L><L><S><L><A><Q><H><L><W><T><L><R><W><M><L><S><R><D><R><A><S><T><L><P><L><P><K><G><S><M><G><W><P><F><F><G><E><T><L><H><W><L><V><Q><G><S><R><F><H><S><S><R><R><E><R><Y><G><T><V><F><K><T><H><L><L><G><R><P><V><I><R><V><S><G><A><E><N><V><R><T><I><L><L><G><E><H><R><L><V><R><S><Q><W><P><Q><S><A><H><I><L><L><G><S><H><T><L><L><G><A><V><G><E><P><H><R><R><R><R><K><V><L><A><R><V><F><S><R><A><A><L><E><R><Y><V><P><R><L><Q><G><A><L><R><H><E><V><R><S><W><C><A><A><G><G><P><V><S><V><Y><D><A><S><K><A><L><T><F><R><M><A><A><R><I><L><L><G><L><R><L><D><E><A><Q><C><A><T><L><A><R><T><F><E><Q><L><V><E><N><L><F><S><L><P><L><D><V><P><F><S><G><L><R><K><G><I><R><A><R><D><Q><L><H><R><H><L><E><G><A><I><S><E><K><L><H><E><D><K><A><A><E><P><G><D><A><L><D><L><I><I><H><S><A><R><E><L><G><H><E><P><S><M><Q><E><L><K><E><S><A><V><E><L><L><F><A><A><F><F><T><T><A><S><A><S><T><S><L><V><L><L><L><L><Q><H><P><A><A><I><A><K><I><R><E><E><L><V><A><Q><G><L><G><R><A><C><G><C><A><P><G><A><A><G><G><S><E><G><P><P><P><D><C><G><C><E><P><D><L><S><L><A><A><L><G><R><L><R><Y><V><D><C><V><V><K><E><V><L><R><L><L><P><P><V><S><G><G><Y><R><T><A><L><R><T><F><E><L><D><G><Y><Q><I><P><K><G><W><S><V><M><Y><S><I><R><D><T><H><E><T><A><A><V><Y><R><S><P><P><E><G><F><D><P><E><R><F><G><A><A><R><E><D><S><R><G><A><S><S><R><F><H><Y><I><P><F><G><G><G><A><R><S><C><L><G><Q><E><L><A><Q><A><V><L><Q><L><L><A><V><E><L><V><R><T><A><R><W><E><L><A><T><P><A><F><P><A><M><Q><T><V><P><I><V><H><P><V><D><G><L><R><L><F><F><H><P><L><T><P><S><V><A><G><N><G><L><C><L>
Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).<BOP>
Q6V0L0
P12104
FABPI_HUMAN
Intestinal-type fatty acid-binding protein
Homo
<M><A><F><D><S><T><W><K><V><D><R><S><E><N><Y><D><K><F><M><E><K><M><G><V><N><I><V><K><R><K><L><A><A><H><D><N><L><K><L><T><I><T><Q><E><G><N><K><F><T><V><K><E><S><S><A><F><R><N><I><E><V><V><F><E><L><G><V><T><F><N><Y><N><L><A><D><G><T><E><L><R><G><T><W><S><L><E><G><N><K><L><I><G><K><F><K><R><T><D><N><G><N><E><L><N><T><V><R><E><I><I><G><D><E><L><V><Q><T><Y><V><Y><E><G><V><E><A><K><R><I><F><K><K><D>
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.<BOP>
P12104
P43355
MAGA1_HUMAN
MAGE-1 antigen
Homo
<M><S><L><E><Q><R><S><L><H><C><K><P><E><E><A><L><E><A><Q><Q><E><A><L><G><L><V><C><V><Q><A><A><T><S><S><S><S><P><L><V><L><G><T><L><E><E><V><P><T><A><G><S><T><D><P><P><Q><S><P><Q><G><A><S><A><F><P><T><T><I><N><F><T><R><Q><R><Q><P><S><E><G><S><S><S><R><E><E><E><G><P><S><T><S><C><I><L><E><S><L><F><R><A><V><I><T><K><K><V><A><D><L><V><G><F><L><L><L><K><Y><R><A><R><E><P><V><T><K><A><E><M><L><E><S><V><I><K><N><Y><K><H><C><F><P><E><I><F><G><K><A><S><E><S><L><Q><L><V><F><G><I><D><V><K><E><A><D><P><T><G><H><S><Y><V><L><V><T><C><L><G><L><S><Y><D><G><L><L><G><D><N><Q><I><M><P><K><T><G><F><L><I><I><V><L><V><M><I><A><M><E><G><G><H><A><P><E><E><E><I><W><E><E><L><S><V><M><E><V><Y><D><G><R><E><H><S><A><Y><G><E><P><R><K><L><L><T><Q><D><L><V><Q><E><K><Y><L><E><Y><R><Q><V><P><D><S><D><P><A><R><Y><E><F><L><W><G><P><R><A><L><A><E><T><S><Y><V><K><V><L><E><Y><V><I><K><V><S><A><R><V><R><F><F><F><P><S><L><R><E><A><A><L><R><E><E><E><E><G><V>
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.<BOP>
P43355
P12645
BMP3_HUMAN
Osteogenin
Homo
<M><A><G><A><S><R><L><L><F><L><W><L><G><C><F><C><V><S><L><A><Q><G><E><R><P><K><P><P><F><P><E><L><R><K><A><V><P><G><D><R><T><A><G><G><G><P><D><S><E><L><Q><P><Q><D><K><V><S><E><H><M><L><R><L><Y><D><R><Y><S><T><V><Q><A><A><R><T><P><G><S><L><E><G><G><S><Q><P><W><R><P><R><L><L><R><E><G><N><T><V><R><S><F><R><A><A><A><A><E><T><L><E><R><K><G><L><Y><I><F><N><L><T><S><L><T><K><S><E><N><I><L><S><A><T><L><Y><F><C><I><G><E><L><G><N><I><S><L><S><C><P><V><S><G><G><C><S><H><H><A><Q><R><K><H><I><Q><I><D><L><S><A><W><T><L><K><F><S><R><N><Q><S><Q><L><L><G><H><L><S><V><D><M><A><K><S><H><R><D><I><M><S><W><L><S><K><D><I><T><Q><L><L><R><K><A><K><E><N><E><E><F><L><I><G><F><N><I><T><S><K><G><R><Q><L><P><K><R><R><L><P><F><P><E><P><Y><I><L><V><Y><A><N><D><A><A><I><S><E><P><E><S><V><V><S><S><L><Q><G><H><R><N><F><P><T><G><T><V><P><K><W><D><S><H><I><R><A><A><L><S><I><E><R><R><K><K><R><S><T><G><V><L><L><P><L><Q><N><N><E><L><P><G><A><E><Y><Q><Y><K><K><D><E><V><W><E><E><R><K><P><Y><K><T><L><Q><A><Q><A><P><E><K><S><K><N><K><K><K><Q><R><K><G><P><H><R><K><S><Q><T><L><Q><F><D><E><Q><T><L><K><K><A><R><R><K><Q><W><I><E><P><R><N><C><A><R><R><Y><L><K><V><D><F><A><D><I><G><W><S><E><W><I><I><S><P><K><S><F><D><A><Y><Y><C><S><G><A><C><Q><F><P><M><P><K><S><L><K><P><S><N><H><A><T><I><Q><S><I><V><R><A><V><G><V><V><P><G><I><P><E><P><C><C><V><P><E><K><M><S><S><L><S><I><L><F><F><D><E><N><K><N><V><V><L><K><V><Y><P><N><M><T><V><E><S><C><A><C><R>
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification . Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways .<BOP>
P12645
Q9H9F9
ARP5_HUMAN
Sarcoma antigen NY-SAR-16
Homo
<M><A><A><N><V><F><P><F><R><D><A><R><A><A><P><D><P><V><L><E><A><G><P><V><A><H><G><P><L><P><V><P><L><V><L><D><N><G><S><F><Q><V><R><A><G><W><A><C><P><G><Q><D><P><G><P><E><P><R><L><Q><F><R><A><V><C><A><R><G><R><G><G><A><R><G><A><S><G><P><Q><V><G><N><A><L><G><S><L><E><P><L><R><W><M><L><R><S><P><F><D><R><N><V><P><V><N><L><E><L><Q><E><L><L><L><D><Y><S><F><Q><H><L><G><V><S><S><Q><G><C><V><D><H><P><I><V><L><T><E><A><V><C><N><P><L><Y><S><R><Q><M><M><S><E><L><L><F><E><C><Y><G><I><P><K><V><A><Y><G><I><D><S><L><F><S><F><Y><H><N><K><P><K><N><S><M><C><S><G><L><I><I><S><S><G><Y><Q><C><T><H><V><L><P><I><L><E><G><R><L><D><A><K><N><C><K><R><I><N><L><G><G><S><Q><A><A><G><Y><L><Q><R><L><L><Q><L><K><Y><P><G><H><L><A><A><I><T><L><S><R><M><E><E><I><L><H><E><H><S><Y><I><A><E><D><Y><V><E><E><L><H><K><W><R><C><P><D><Y><Y><E><N><N><V><H><K><M><Q><L><P><F><S><S><K><L><L><G><S><T><L><T><S><E><E><K><Q><E><R><R><Q><Q><Q><L><R><R><L><Q><E><L><N><A><R><R><R><E><E><K><L><Q><L><D><Q><E><R><L><D><R><L><L><Y><V><Q><E><L><L><E><D><G><Q><M><D><Q><F><H><K><A><L><I><E><L><N><M><D><S><P><E><E><L><Q><S><Y><I><Q><K><L><S><I><A><V><E><Q><A><K><Q><K><I><L><Q><A><E><V><N><L><E><V><D><V><V><D><S><K><P><E><T><P><D><L><E><Q><L><E><P><S><L><E><D><V><E><S><M><N><D><F><D><P><L><F><S><E><E><T><P><G><V><E><K><P><V><T><T><V><Q><P><V><F><N><L><A><A><Y><H><Q><L><F><V><G><T><E><R><I><R><A><P><E><I><I><F><Q><P><S><L><I><G><E><E><Q><A><G><I><A><E><T><L><Q><Y><I><L><D><R><Y><P><K><D><I><Q><E><M><L><V><Q><N><V><F><L><T><G><G><N><T><M><Y><P><G><M><K><A><R><M><E><K><E><L><L><E><M><R><P><F><R><S><S><F><Q><V><Q><L><A><S><N><P><V><L><D><A><W><Y><G><A><R><D><W><A><L><N><H><L><D><D><N><E><V><W><I><T><R><K><E><Y><E><E><K><G><G><E><Y><L><K><E><H><C><A><S><N><I><Y><V><P><I><R><L><P><K><Q><A><S><R><S><S><D><A><Q><A><S><S><K><G><S><A><A><G><G><G><G><A><G><E><Q><A>
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.<BOP>
Q9H9F9
Q9NXG6
P4HTM_HUMAN
Hypoxia-inducible factor prolyl hydroxylase 4
Homo
<M><A><A><A><A><V><T><G><Q><R><P><E><T><A><A><A><E><E><A><S><R><P><Q><W><A><P><P><D><H><C><Q><A><Q><A><A><A><G><L><G><D><G><E><D><A><P><V><R><P><L><C><K><P><R><G><I><C><S><R><A><Y><F><L><V><L><M><V><F><V><H><L><Y><L><G><N><V><L><A><L><L><L><F><V><H><Y><S><N><G><D><E><S><S><D><P><G><P><Q><H><R><A><Q><G><P><G><P><E><P><T><L><G><P><L><T><R><L><E><G><I><K><V><G><H><E><R><K><V><Q><L><V><T><D><R><D><H><F><I><R><T><L><S><L><K><P><L><L><F><E><I><P><G><F><L><T><D><E><E><C><R><L><I><I><H><L><A><Q><M><K><G><L><Q><R><S><Q><I><L><P><T><E><E><Y><E><E><A><M><S><T><M><Q><V><S><Q><L><D><L><F><R><L><L><D><Q><N><R><D><G><H><L><Q><L><R><E><V><L><A><Q><T><R><L><G><N><G><W><W><M><T><P><E><S><I><Q><E><M><Y><A><A><I><K><A><D><P><D><G><D><G><V><L><S><L><Q><E><F><S><N><M><D><L><R><D><F><H><K><Y><M><R><S><H><K><A><E><S><S><E><L><V><R><N><S><H><H><T><W><L><Y><Q><G><E><G><A><H><H><I><M><R><A><I><R><Q><R><V><L><R><L><T><R><L><S><P><E><I><V><E><L><S><E><P><L><Q><V><V><R><Y><G><E><G><G><H><Y><H><A><H><V><D><S><G><P><V><Y><P><E><T><I><C><S><H><T><K><L><V><A><N><E><S><V><P><F><E><T><S><C><R><Y><M><T><V><L><F><Y><L><N><N><V><T><G><G><G><E><T><V><F><P><V><A><D><N><R><T><Y><D><E><M><S><L><I><Q><D><D><V><D><L><R><D><T><R><R><H><C><D><K><G><N><L><R><V><K><P><Q><Q><G><T><A><V><F><W><Y><N><Y><L><P><D><G><Q><G><W><V><G><D><V><D><D><Y><S><L><H><G><G><C><L><V><T><R><G><T><K><W><I><A><N><N><W><I><N><V><D><P><S><R><A><R><Q><A><L><F><Q><Q><E><M><A><R><L><A><R><E><G><G><T><D><S><Q><P><E><W><A><L><D><R><A><Y><R><D><A><R><V><E><L>
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.<BOP>
Q9NXG6
O95999
BCL10_HUMAN
Mammalian CARD-containing adapter molecule E10
Homo
<M><E><P><T><A><P><S><L><T><E><E><D><L><T><E><V><K><K><D><A><L><E><N><L><R><V><Y><L><C><E><K><I><I><A><E><R><H><F><D><H><L><R><A><K><K><I><L><S><R><E><D><T><E><E><I><S><C><R><T><S><S><R><K><R><A><G><K><L><L><D><Y><L><Q><E><N><P><K><G><L><D><T><L><V><E><S><I><R><R><E><K><T><Q><N><F><L><I><Q><K><I><T><D><E><V><L><K><L><R><N><I><K><L><E><H><L><K><G><L><K><C><S><S><C><E><P><F><P><D><G><A><T><N><N><L><S><R><S><N><S><D><E><S><N><F><S><E><K><L><R><A><S><T><V><M><Y><H><P><E><G><E><S><S><T><T><P><F><F><S><T><N><S><S><L><N><L><P><V><L><E><V><G><R><T><E><N><T><I><F><S><S><T><T><L><P><R><P><G><D><P><G><A><P><P><L><P><P><D><L><Q><L><E><E><E><G><T><C><A><N><S><S><E><M><F><L><P><L><R><S><R><T><V><S><R><Q>
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation . Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex . This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity . Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor
O95999
Q12889
OVGP1_HUMAN
Oviductin
Homo
<M><W><K><L><L><L><W><V><G><L><V><L><V><L><K><H><H><D><G><A><A><H><K><L><V><C><Y><F><T><N><W><A><H><S><R><P><G><P><A><S><I><L><P><H><D><L><D><P><F><L><C><T><H><L><I><F><A><F><A><S><M><N><N><N><Q><I><V><A><K><D><L><Q><D><E><K><I><L><Y><P><E><F><N><K><L><K><E><R><N><R><E><L><K><T><L><L><S><I><G><G><W><N><F><G><T><S><R><F><T><T><M><L><S><T><F><A><N><R><E><K><F><I><A><S><V><I><S><L><L><R><T><H><D><F><D><G><L><D><L><F><F><L><Y><P><G><L><R><G><S><P><M><H><D><R><W><T><F><L><F><L><I><E><E><L><L><F><A><F><R><K><E><A><L><L><T><M><R><P><R><L><L><L><S><A><A><V><S><G><V><P><H><I><V><Q><T><S><Y><D><V><R><F><L><G><R><L><L><D><F><I><N><V><L><S><Y><D><L><H><G><S><W><E><R><F><T><G><H><N><S><P><L><F><S><L><P><E><D><P><K><S><S><A><Y><A><M><N><Y><W><R><K><L><G><A><P><S><E><K><L><I><M><G><I><P><T><Y><G><R><T><F><R><L><L><K><A><S><K><N><G><L><Q><A><R><A><I><G><P><A><S><P><G><K><Y><T><K><Q><E><G><F><L><A><Y><F><E><I><C><S><F><V><W><G><A><K><K><H><W><I><D><Y><Q><Y><V><P><Y><A><N><K><G><K><E><W><V><G><Y><D><N><A><I><S><F><S><Y><K><A><W><F><I><R><R><E><H><F><G><G><A><M><V><W><T><L><D><M><D><D><V><R><G><T><F><C><G><T><G><P><F><P><L><V><Y><V><L><N><D><I><L><V><R><A><E><F><S><S><T><S><L><P><Q><F><W><L><S><S><A><V><N><S><S><S><T><D><P><E><R><L><A><V><T><T><A><W><T><T><D><S><K><I><L><P><P><G><G><E><A><G><V><T><E><I><H><G><K><C><E><N><M><T><I><T><P><R><G><T><T><V><T><P><T><K><E><T><V><S><L><G><K><H><T><V><A><L><G><E><K><T><E><I><T><G><A><M><T><M><T><S><V><G><H><Q><S><M><T><P><G><E><K><A><L><T><P><V><G><H><Q><S><V><T><T><G><Q><K><T><L><T><S><V><G><Y><Q><S><V><T><P><G><E><K><T><L><T><P><V><G><H><Q><S><V><T><P><V><S><H><Q><S><V><S><P><G><G><T><T><M><T><P><V><H><F><Q><T><E><T><L><R><Q><N><T><V><A><P><R><R><K><A><V><A><R><E><K><V><T><V><P><S><R><N><I><S><V><T><P><E><G><Q><T><M><P><L><R><G><E><N><L><T><S><E><V><G><T><H><P><R><M><G><N><L><G><L><Q><M><E><A><E><N><R><M><M><L><S><S><S><P><V><I><Q><L><P><E><Q><T><P><L><A><F><D><N><R><F><V><P><I><Y><G><N><H><S><S><V><N><S><V><T><P><Q><T><S><P><L><S><L><K><K><E><I><P><E><N><S><A><V><D><E><E><A>
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.<BOP>
Q12889
Q9BXB5
OSB10_HUMAN
Oxysterol-binding protein-related protein 10
Homo
<M><E><R><A><V><Q><G><T><D><G><G><G><G><S><N><S><S><S><R><S><S><S><R><A><T><S><A><G><S><S><P><S><C><S><L><A><G><R><G><V><S><S><R><S><A><A><A><G><L><G><G><G><G><S><R><S><S><P><G><S><V><A><A><S><P><S><G><G><G><G><R><R><R><E><P><A><L><E><G><V><L><S><K><Y><T><N><L><L><Q><G><W><Q><N><R><Y><F><V><L><D><F><E><A><G><I><L><Q><Y><F><V><N><E><Q><S><K><H><Q><K><P><R><G><V><L><S><L><S><G><A><I><V><S><L><S><D><E><A><P><H><M><L><V><V><Y><S><A><N><G><E><M><F><K><L><R><A><A><D><A><K><E><K><Q><F><W><V><T><Q><L><R><A><C><A><K><Y><H><M><E><M><N><S><K><S><A><P><S><S><R><S><R><S><L><T><L><L><P><H><G><T><P><N><S><A><S><P><C><S><Q><R><H><L><S><V><G><A><P><G><V><V><T><I><T><H><H><K><S><P><A><A><A><R><R><A><K><S><Q><Y><S><G><Q><L><H><E><V><R><E><M><M><N><Q><V><E><G><Q><Q><K><N><L><V><H><A><I><E><S><L><P><G><S><G><P><L><T><A><L><D><Q><D><L><L><L><L><K><A><T><S><A><A><T><L><S><C><L><G><E><C><L><N><L><L><Q><Q><S><V><H><Q><A><G><Q><P><S><Q><K><P><G><A><S><E><N><I><L><G><W><H><G><S><K><S><H><S><T><E><Q><L><K><N><G><T><L><G><S><L><P><S><A><S><A><N><I><T><W><A><I><L><P><N><S><A><E><D><E><Q><T><S><Q><P><E><P><E><P><N><S><G><S><E><L><V><L><S><E><D><E><K><S><D><N><E><D><K><E><E><T><E><L><G><V><M><E><D><Q><R><S><I><I><L><H><L><I><S><Q><L><K><L><G><M><D><L><T><K><V><V><L><P><T><F><I><L><E><K><R><S><L><L><E><M><Y><A><D><F><M><A><H><P><D><L><L><L><A><I><T><A><G><A><T><P><E><E><R><V><I><C><F><V><E><Y><Y><L><T><A><F><H><E><G><R><K><G><A><L><A><K><K><P><Y><N><P><I><I><G><E><T><F><H><C><S><W><E><V><P><K><D><R><V><K><P><K><R><T><A><S><R><S><P><A><S><C><H><E><H><P><M><A><D><D><P><S><K><S><Y><K><L><R><F><V><A><E><Q><V><S><H><H><P><P><I><S><C><F><Y><C><E><C><E><E><K><R><L><C><V><N><T><H><V><W><T><K><S><K><F><M><G><M><S><V><G><V><S><M><I><G><E><G><V><L><R><L><L><E><H><G><E><E><Y><V><F><T><L><P><S><A><Y><A><R><S><I><L><T><I><P><W><V><E><L><G><G><K><V><S><I><N><C><A><K><T><G><Y><S><A><T><V><I><F><H><T><K><P><F><Y><G><G><K><V><H><R><V><T><A><E><V><K><H><N><P><T><N><T><I><V><C><K><A><H><G><E><W><N><G><T><L><E><F><T><Y><N><N><G><E><T><K><V><I><D><T><T><T><L><P><V><Y><P><K><K><I><R><P><L><E><K><Q><G><P><M><E><S><R><N><L><W><R><E><V><T><R><Y><L><R><L><G><D><I><D><A><A><T><E><Q><K><R><H><L><E><E><K><Q><R><V><E><E><R><K><R><E><N><L><R><T><P><W><K><P><K><Y><F><I><Q><E><G><D><G><W><V><Y><F><N><P><L><W><K><A><H>
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis . Negatively regulates APOB secretion from hepatocytes . Binds cholesterol and acidic phospholipids . Also binds 25-hydroxycholesterol . Binds phosphatidylserine .<BOP>
Q9BXB5
P09493
TPM1_HUMAN
Tropomyosin-1
Homo
<M><D><A><I><K><K><K><M><Q><M><L><K><L><D><K><E><N><A><L><D><R><A><E><Q><A><E><A><D><K><K><A><A><E><D><R><S><K><Q><L><E><D><E><L><V><S><L><Q><K><K><L><K><G><T><E><D><E><L><D><K><Y><S><E><A><L><K><D><A><Q><E><K><L><E><L><A><E><K><K><A><T><D><A><E><A><D><V><A><S><L><N><R><R><I><Q><L><V><E><E><E><L><D><R><A><Q><E><R><L><A><T><A><L><Q><K><L><E><E><A><E><K><A><A><D><E><S><E><R><G><M><K><V><I><E><S><R><A><Q><K><D><E><E><K><M><E><I><Q><E><I><Q><L><K><E><A><K><H><I><A><E><D><A><D><R><K><Y><E><E><V><A><R><K><L><V><I><I><E><S><D><L><E><R><A><E><E><R><A><E><L><S><E><G><K><C><A><E><L><E><E><E><L><K><T><V><T><N><N><L><K><S><L><E><A><Q><A><E><K><Y><S><Q><K><E><D><R><Y><E><E><E><I><K><V><L><S><D><K><L><K><E><A><E><T><R><A><E><F><A><E><R><S><V><T><K><L><E><K><S><I><D><D><L><E><D><E><L><Y><A><Q><K><L><K><Y><K><A><I><S><E><E><L><D><H><A><L><N><D><M><T><S><I>
Binds to actin filaments in muscle and non-muscle cells . Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction . Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.<BOP>
P09493
P21754
ZP3_HUMAN
Processed zona pellucida sperm-binding protein 3
Homo
<M><E><L><S><Y><R><L><F><I><C><L><L><L><W><G><S><T><E><L><C><Y><P><Q><P><L><W><L><L><Q><G><G><A><S><H><P><E><T><S><V><Q><P><V><L><V><E><C><Q><E><A><T><L><M><V><M><V><S><K><D><L><F><G><T><G><K><L><I><R><A><A><D><L><T><L><G><P><E><A><C><E><P><L><V><S><M><D><T><E><D><V><V><R><F><E><V><G><L><H><E><C><G><N><S><M><Q><V><T><D><D><A><L><V><Y><S><T><F><L><L><H><D><P><R><P><V><G><N><L><S><I><V><R><T><N><R><A><E><I><P><I><E><C><R><Y><P><R><Q><G><N><V><S><S><Q><A><I><L><P><T><W><L><P><F><R><T><T><V><F><S><E><E><K><L><T><F><S><L><R><L><M><E><E><N><W><N><A><E><K><R><S><P><T><F><H><L><G><D><A><A><H><L><Q><A><E><I><H><T><G><S><H><V><P><L><R><L><F><V><D><H><C><V><A><T><P><T><P><D><Q><N><A><S><P><Y><H><T><I><V><D><F><H><G><C><L><V><D><G><L><T><D><A><S><S><A><F><K><V><P><R><P><G><P><D><T><L><Q><F><T><V><D><V><F><H><F><A><N><D><S><R><N><M><I><Y><I><T><C><H><L><K><V><T><L><A><E><Q><D><P><D><E><L><N><K><A><C><S><F><S><K><P><S><N><S><W><F><P><V><E><G><S><A><D><I><C><Q><C><C><N><K><G><D><C><G><T><P><S><H><S><R><R><Q><P><H><V><M><S><Q><W><S><R><S><A><S><R><N><R><R><H><V><T><E><E><A><D><V><T><V><G><P><L><I><F><L><D><R><R><G><D><H><E><V><E><Q><W><A><L><P><S><D><T><S><V><V><L><L><G><V><G><L><A><V><V><V><S><L><T><L><T><A><V><I><L><V><L><T><R><R><C><R><T><A><S><H><P><V><S><A><S><E>
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.<BOP>
P21754
Q8NEV1
CSK23_HUMAN
Casein kinase II alpha 1 polypeptide pseudogene
Homo
<M><S><G><P><V><P><S><R><A><R><V><Y><T><D><V><N><T><H><R><P><R><E><Y><W><D><Y><E><S><H><V><V><E><W><G><N><Q><D><D><Y><Q><L><V><R><K><L><G><R><G><K><Y><S><E><V><F><E><A><I><N><I><T><N><N><E><K><V><V><V><K><I><L><K><P><V><K><K><K><K><I><K><R><E><I><K><I><L><E><N><L><R><G><G><P><N><I><I><T><L><A><D><I><V><K><D><P><V><S><R><T><P><A><L><V><F><E><H><V><N><N><T><D><F><K><Q><L><Y><Q><T><L><T><D><Y><D><I><R><F><Y><M><Y><E><I><L><K><A><L><D><Y><C><H><S><M><G><I><M><H><R><D><V><K><P><H><N><V><M><I><D><H><E><H><R><K><L><R><L><I><D><W><G><L><A><E><F><Y><H><P><G><Q><E><Y><N><V><R><V><A><S><R><Y><F><K><G><P><E><L><L><V><D><Y><Q><M><Y><D><Y><S><L><D><M><W><R><L><G><C><M><L><A><S><M><I><F><R><K><E><P><F><F><H><G><R><D><N><Y><D><Q><L><V><R><I><A><K><F><L><G><T><E><D><L><Y><G><Y><I><D><K><Y><N><I><E><L><D><P><R><F><N><D><I><L><G><R><H><S><R><K><R><W><E><R><F><V><H><S><E><N><Q><H><L><V><S><P><E><A><L><D><F><L><D><K><L><L><R><Y><D><H><Q><S><R><L><T><A><R><E><A><M><E><H><P><Y><F><Y><T><V><V><K><D><Q><A><R><M><G><S><S><S><M><P><G><G><S><T><P><V><S><S><A><N><V><M><S><G><I><S><S><V><P><T><P><S><P><L><G><P><L><A><G><S><P><V><I><A><A><A><N><P><L><G><M><P><V><P><A><A><T><G><A><Q><Q>
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.<BOP>
Q8NEV1
O43920
NDUS5_HUMAN
NADH-ubiquinone oxidoreductase 15 kDa subunit
Homo
<M><P><F><L><D><I><Q><K><R><F><G><L><N><I><D><R><W><L><T><I><Q><S><G><E><Q><P><Y><K><M><A><G><R><C><H><A><F><E><K><E><W><I><E><C><A><H><G><I><G><Y><T><R><A><E><K><E><C><K><I><E><Y><D><D><F><V><E><C><L><L><R><Q><K><T><M><R><R><A><G><T><I><R><K><Q><R><D><K><L><I><K><E><G><K><Y><T><P><P><P><H><H><I><G><K><G><E><P><R><P>
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP>
O43920
Q13015
AF1Q_HUMAN
Protein AF1q
Homo
<M><R><D><P><V><S><S><Q><Y><S><S><F><L><F><W><R><M><P><I><P><E><L><D><L><S><E><L><E><G><L><G><L><S><D><T><A><T><Y><K><V><K><D><S><S><V><G><K><M><I><G><Q><A><T><A><A><D><Q><E><K><N><P><E><G><D><G><L><L><E><Y><S><T><F><N><F><W><R><A><P><I><A><S><I><H><S><F><E><L><D><L><L>
Cofactor for the transcription factor TCF7 . Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate .<BOP>
Q13015
O43236
SEPT4_HUMAN
Peanut-like protein 2
Homo
<M><D><R><S><L><G><W><Q><G><N><S><V><P><E><D><R><T><E><A><G><I><K><R><F><L><E><D><T><T><D><D><G><E><L><S><K><F><V><K><D><F><S><G><N><A><S><C><H><P><P><E><A><K><T><W><A><S><R><P><Q><V><P><E><P><R><P><Q><A><P><D><L><Y><D><D><D><L><E><F><R><P><P><S><R><P><Q><S><S><D><N><Q><Q><Y><F><C><A><P><A><P><L><S><P><S><A><R><P><R><S><P><W><G><K><L><D><P><Y><D><S><S><E><D><D><K><E><Y><V><G><F><A><T><L><P><N><Q><V><H><R><K><S><V><K><K><G><F><D><F><T><L><M><V><A><G><E><S><G><L><G><K><S><T><L><V><N><S><L><F><L><T><D><L><Y><R><D><R><K><L><L><G><A><E><E><R><I><M><Q><T><V><E><I><T><K><H><A><V><D><I><E><E><K><G><V><R><L><R><L><T><I><V><D><T><P><G><F><G><D><A><V><N><N><T><E><C><W><K><P><V><A><E><Y><I><D><Q><Q><F><E><Q><Y><F><R><D><E><S><G><L><N><R><K><N><I><Q><D><N><R><V><H><C><C><L><Y><F><I><S><P><F><G><H><G><L><R><P><L><D><V><E><F><M><K><A><L><H><Q><R><V><N><I><V><P><I><L><A><K><A><D><T><L><T><P><P><E><V><D><H><K><K><R><K><I><R><E><E><I><E><H><F><G><I><K><I><Y><Q><F><P><D><C><D><S><D><E><D><E><D><F><K><L><Q><D><Q><A><L><K><E><S><I><P><F><A><V><I><G><S><N><T><V><V><E><A><R><G><R><R><V><R><G><R><L><Y><P><W><G><I><V><E><V><E><N><P><G><H><C><D><F><V><K><L><R><T><M><L><V><R><T><H><M><Q><D><L><K><D><V><T><R><E><T><H><Y><E><N><Y><R><A><Q><C><I><Q><S><M><T><R><L><V><V><K><E><R><N><R><N><K><L><T><R><E><S><G><T><D><F><P><I><P><A><V><P><P><G><T><D><P><E><T><E><K><L><I><R><E><K><D><E><E><L><R><R><M><Q><E><M><L><H><K><I><Q><K><Q><M><K><E><N><Y>
Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli . Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death . Mediates the interaction between BCL2 and XIAP, thereby positively regulating the ubiquitination and degradation of BCL2 and promoting apoptosis .<BOP>
O43236
P49716
CEBPD_HUMAN
Nuclear factor NF-IL6-beta
Homo
<M><S><A><A><L><F><S><L><D><G><P><A><R><G><A><P><W><P><A><E><P><A><P><F><Y><E><P><G><R><A><G><K><P><G><R><G><A><E><P><G><A><L><G><E><P><G><A><A><A><P><A><M><Y><D><D><E><S><A><I><D><F><S><A><Y><I><D><S><M><A><A><V><P><T><L><E><L><C><H><D><E><L><F><A><D><L><F><N><S><N><H><K><A><G><G><A><G><P><L><E><L><L><P><G><G><P><A><R><P><L><G><P><G><P><A><A><P><R><L><L><K><R><E><P><D><W><G><D><G><D><A><P><G><S><L><L><P><A><Q><V><A><A><C><A><Q><T><V><V><S><L><A><A><A><G><Q><P><T><P><P><T><S><P><E><P><P><R><S><S><P><R><Q><T><P><A><P><G><P><A><R><E><K><S><A><G><K><R><G><P><D><R><G><S><P><E><Y><R><Q><R><R><E><R><N><N><I><A><V><R><K><S><R><D><K><A><K><R><R><N><Q><E><M><Q><Q><K><L><V><E><L><S><A><E><N><E><K><L><H><Q><R><V><E><Q><L><T><R><D><L><A><G><L><R><Q><F><F><K><Q><L><P><S><P><P><F><L><P><A><A><G><T><A><D><C><R>
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers . Important transcription factor regulating the expression of genes involved in immune and inflammatory responses . Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB .<BOP>
P49716
Q5H9S7
DCA17_HUMAN
DDB1- and CUL4-associated factor 17
Homo
<M><G><P><T><R><K><P><N><V><C><S><R><L><S><R><R><A><L><G><C><F><S><R><D><A><G><V><V><Q><R><T><N><L><G><I><L><R><A><L><V><C><Q><E><S><T><K><F><K><N><V><W><T><T><H><S><R><S><P><I><A><Y><E><R><G><R><I><Y><F><D><N><Y><R><R><C><V><S><S><V><A><S><E><P><R><K><L><Y><E><M><P><K><C><S><K><S><E><K><I><E><D><A><L><L><W><E><C><P><V><G><D><I><L><P><N><S><S><D><Y><K><S><S><L><I><A><L><T><A><H><N><W><L><L><R><I><S><A><T><T><G><K><I><L><E><K><I><Y><L><A><P><Y><C><K><F><R><Y><L><S><W><D><T><P><Q><E><V><I><A><V><K><S><A><Q><N><R><G><S><A><V><A><R><Q><A><G><I><Q><Q><H><V><L><L><Y><L><A><V><F><R><V><L><P><F><S><L><V><G><I><L><E><I><N><K><K><I><F><G><N><V><T><D><A><T><L><S><H><G><I><L><I><V><M><Y><S><S><G><L><V><R><L><Y><S><F><Q><T><I><A><E><Q><F><M><Q><Q><K><L><D><L><G><C><A><C><R><W><G><G><T><T><G><T><V><G><E><A><P><F><G><I><P><C><N><I><K><I><T><D><M><P><P><L><L><F><E><V><S><S><L><E><N><A><F><Q><I><G><G><H><P><W><H><Y><I><V><T><P><N><K><K><K><Q><K><G><V><F><H><I><C><A><L><K><D><N><S><L><A><K><N><G><I><Q><E><M><D><C><C><S><L><E><S><D><W><I><Y><F><H><P><D><A><S><G><R><I><I><H><V><G><P><N><Q><V><K><V><L><K><L><T><E><I><E><N><N><S><S><Q><H><Q><I><S><E><D><F><V><I><L><A><N><R><E><N><H><K><N><E><N><V><L><T><V><T><A><S><G><R><V><V><K><K><S><F><N><L><L><D><D><D><P><E><Q><E><T><F><K><I><V><D><Y><E><D><E><L><D><L><L><S><V><V><A><V><T><Q><I><D><A><E><G><K><A><H><L><D><F><H><C><N><E><Y><G><T><L><L><K><S><I><P><L><V><E><S><W><D><V><T><Y><S><H><E><V><Y><F><D><R><D><L><V><L><H><I><E><Q><K><P><N><R><V><F><S><C><Y><V><Y><Q><M><I><C><D><T><G><E><E><E><E><T><I><N><R><S><C>
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.<BOP>
Q5H9S7
Q9NYL4
FKB11_HUMAN
Rotamase
Homo
<M><T><L><R><P><S><L><L><P><L><H><L><L><L><L><L><L><L><S><A><A><V><C><R><A><E><A><G><L><E><T><E><S><P><V><R><T><L><Q><V><E><T><L><V><E><P><P><E><P><C><A><E><P><A><A><F><G><D><T><L><H><I><H><Y><T><G><S><L><V><D><G><R><I><I><D><T><S><L><T><R><D><P><L><V><I><E><L><G><Q><K><Q><V><I><P><G><L><E><Q><S><L><L><D><M><C><V><G><E><K><R><R><A><I><I><P><S><H><L><A><Y><G><K><R><G><F><P><P><S><V><P><A><D><A><V><V><Q><Y><D><V><E><L><I><A><L><I><R><A><N><Y><W><L><K><L><V><K><G><I><L><P><L><V><G><M><A><M><V><P><A><L><L><G><L><I><G><Y><H><L><Y><R><K><A><N><R><P><K><V><S><K><K><K><L><K><E><E><K><R><N><K><S><K><K><K>
PPIases accelerate the folding of proteins during protein synthesis.<BOP>
Q9NYL4
Q9UHD4
CIDEB_HUMAN
Cell death-inducing DFFA-like effector B
Homo
<M><E><Y><L><S><A><L><N><P><S><D><L><L><R><S><V><S><N><I><S><S><E><F><G><R><R><V><W><T><S><A><P><P><P><Q><R><P><F><R><V><C><D><H><K><R><T><I><R><K><G><L><T><A><A><T><R><Q><E><L><L><A><K><A><L><E><T><L><L><L><N><G><V><L><T><L><V><L><E><E><D><G><T><A><V><D><S><E><D><F><F><Q><L><L><E><D><D><T><C><L><M><V><L><Q><S><G><Q><S><W><S><P><T><R><S><G><V><L><S><Y><G><L><G><R><E><R><P><K><H><S><K><D><I><A><R><F><T><F><D><V><Y><K><Q><N><P><R><D><L><F><G><S><L><N><V><K><A><T><F><Y><G><L><Y><S><M><S><C><D><F><Q><G><L><G><P><K><K><V><L><R><E><L><L><R><W><T><S><T><L><L><Q><G><L><G><H><M><L><L><G><I><S><S><T><L><R><H><A><V><E><G><A><E><Q><W><Q><Q><K><G><R><L><H><S><Y>
(Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.<BOP>
Q9UHD4
Q86XT2
VP37D_HUMAN
Williams-Beuren syndrome chromosomal region 24 protein
Homo
<M><Y><R><A><R><A><A><R><A><G><P><E><P><G><S><P><G><R><F><G><I><L><S><T><G><Q><L><R><D><L><L><Q><D><E><P><K><L><D><R><I><V><R><L><S><R><K><F><Q><G><L><Q><L><E><R><E><A><C><L><A><S><N><Y><A><L><A><K><E><N><L><A><L><R><P><R><L><E><M><G><R><A><A><L><A><I><K><Y><Q><E><L><R><E><V><A><E><N><C><A><D><K><L><Q><R><L><E><E><S><M><H><R><W><S><P><H><C><A><L><G><W><L><Q><A><E><L><E><E><A><E><Q><E><A><E><E><Q><M><E><Q><L><L><L><G><E><Q><S><L><E><A><F><L><P><A><F><Q><R><G><R><A><L><A><H><L><R><R><T><Q><A><E><K><L><Q><E><L><L><R><R><R><E><R><S><A><Q><P><A><P><T><S><A><A><D><P><P><K><S><F><P><A><A><A><V><L><P><T><G><A><A><R><G><P><P><A><V><P><R><S><L><P><P><L><D><S><R><P><V><P><P><L><K><G><S><P><G><C><P><L><G><P><A><P><L><L><S><P><R><P><S><Q><P><E><P><P><H><R>
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.<BOP>
Q86XT2
A0A0J9YVY3
HV741_HUMAN
Immunoglobulin heavy variable 7-4-1
Homo
<M><D><W><T><W><R><I><L><F><L><V><A><A><A><T><G><A><H><S><Q><V><Q><L><V><Q><S><G><S><E><L><K><K><P><G><A><S><V><K><V><S><C><K><A><S><G><Y><T><F><T><S><Y><A><M><N><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><W><I><N><T><N><T><G><N><P><T><Y><A><Q><G><F><T><G><R><F><V><F><S><L><D><T><S><V><S><T><A><Y><L><Q><I><C><S><L><K><A><E><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0J9YVY3
Q9BWW4
SSBP3_HUMAN
Sequence-specific single-stranded-DNA-binding protein
Homo
<M><F><A><K><G><K><G><S><A><V><P><S><D><G><Q><A><R><E><K><L><A><L><Y><V><Y><E><Y><L><L><H><V><G><A><Q><K><S><A><Q><T><F><L><S><E><I><R><W><E><K><N><I><T><L><G><E><P><P><G><F><L><H><S><W><W><C><V><F><W><D><L><Y><C><A><A><P><E><R><R><D><T><C><E><H><S><S><E><A><K><A><F><H><D><Y><S><A><A><A><A><P><S><P><V><L><G><N><I><P><P><N><D><G><M><P><G><G><P><I><P><P><G><F><F><Q><G><P><P><G><S><Q><P><S><P><H><A><Q><P><P><P><H><N><P><S><S><M><M><G><P><H><S><Q><P><F><M><S><P><R><Y><A><G><G><P><R><P><P><I><R><M><G><N><Q><P><P><G><G><V><P><G><T><Q><P><L><L><P><N><S><M><D><P><T><R><Q><Q><G><H><P><N><M><G><G><S><M><Q><R><M><N><P><P><R><G><M><G><P><M><G><P><G><P><Q><N><Y><G><S><G><M><R><P><P><P><N><S><L><G><P><A><M><P><G><I><N><M><G><P><G><A><G><R><P><W><P><N><P><N><S><A><N><S><I><P><Y><S><S><S><S><P><G><T><Y><V><G><P><P><G><G><G><G><P><P><G><T><P><I><M><P><S><P><A><D><S><T><N><S><S><D><N><I><Y><T><M><I><N><P><V><P><P><G><G><S><R><S><N><F><P><M><G><P><G><S><D><G><P><M><G><G><M><G><G><M><E><P><H><H><M><N><G><S><L><G><S><G><D><I><D><G><L><P><K><N><S><P><N><N><I><S><G><I><S><N><P><P><G><T><P><R><D><D><G><E><L><G><G><N><F><L><H><S><F><Q><N><D><N><Y><S><P><S><M><T><M><S><V>
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.<BOP>
Q9BWW4
O94808
GFPT2_HUMAN
Hexosephosphate aminotransferase 2
Homo
<M><C><G><I><F><A><Y><M><N><Y><R><V><P><R><T><R><K><E><I><F><E><T><L><I><K><G><L><Q><R><L><E><Y><R><G><Y><D><S><A><G><V><A><I><D><G><N><N><H><E><V><K><E><R><H><I><Q><L><V><K><K><R><G><K><V><K><A><L><D><E><E><L><Y><K><Q><D><S><M><D><L><K><V><E><F><E><T><H><F><G><I><A><H><T><R><W><A><T><H><G><V><P><S><A><V><N><S><H><P><Q><R><S><D><K><G><N><E><F><V><V><I><H><N><G><I><I><T><N><Y><K><D><L><R><K><F><L><E><S><K><G><Y><E><F><E><S><E><T><D><T><E><T><I><A><K><L><I><K><Y><V><F><D><N><R><E><T><E><D><I><T><F><S><T><L><V><E><R><V><I><Q><Q><L><E><G><A><F><A><L><V><F><K><S><V><H><Y><P><G><E><A><V><A><T><R><R><G><S><P><L><L><I><G><V><R><S><K><Y><K><L><S><T><E><Q><I><P><I><L><Y><R><T><C><T><L><E><N><V><K><N><I><C><K><T><R><M><K><R><L><D><S><S><A><C><L><H><A><V><G><D><K><A><V><E><F><F><F><A><S><D><A><S><A><I><I><E><H><T><N><R><V><I><F><L><E><D><D><D><I><A><A><V><A><D><G><K><L><S><I><H><R><V><K><R><S><A><S><D><D><P><S><R><A><I><Q><T><L><Q><M><E><L><Q><Q><I><M><K><G><N><F><S><A><F><M><Q><K><E><I><F><E><Q><P><E><S><V><F><N><T><M><R><G><R><V><N><F><E><T><N><T><V><L><L><G><G><L><K><D><H><L><K><E><I><R><R><C><R><R><L><I><V><I><G><C><G><T><S><Y><H><A><A><V><A><T><R><Q><V><L><E><E><L><T><E><L><P><V><M><V><E><L><A><S><D><F><L><D><R><N><T><P><V><F><R><D><D><V><C><F><F><I><S><Q><S><G><E><T><A><D><T><L><L><A><L><R><Y><C><K><D><R><G><A><L><T><V><G><V><T><N><T><V><G><S><S><I><S><R><E><T><D><C><G><V><H><I><N><A><G><P><E><I><G><V><A><S><T><K><A><Y><T><S><Q><F><I><S><L><V><M><F><G><L><M><M><S><E><D><R><I><S><L><Q><N><R><R><Q><E><I><I><R><G><L><R><S><L><P><E><L><I><K><E><V><L><S><L><E><E><K><I><H><D><L><A><L><E><L><Y><T><Q><R><S><L><L><V><M><G><R><G><Y><N><Y><A><T><C><L><E><G><A><L><K><I><K><E><I><T><Y><M><H><S><E><G><I><L><A><G><E><L><K><H><G><P><L><A><L><I><D><K><Q><M><P><V><I><M><V><I><M><K><D><P><C><F><A><K><C><Q><N><A><L><Q><Q><V><T><A><R><Q><G><R><P><I><I><L><C><S><K><D><D><T><E><S><S><K><F><A><Y><K><T><I><E><L><P><H><T><V><D><C><L><Q><G><I><L><S><V><I><P><L><Q><L><L><S><F><H><L><A><V><L><R><G><Y><D><V><D><F><P><R><N><L><A><K><S><V><T><V><E>
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.<BOP>
O94808
Q15561
TEAD4_HUMAN
Transcription factor RTEF-1
Homo
<M><E><G><T><A><G><T><I><T><S><N><E><W><S><S><P><T><S><P><E><G><S><T><A><S><G><G><S><Q><A><L><D><K><P><I><D><N><D><A><E><G><V><W><S><P><D><I><E><Q><S><F><Q><E><A><L><A><I><Y><P><P><C><G><R><R><K><I><I><L><S><D><E><G><K><M><Y><G><R><N><E><L><I><A><R><Y><I><K><L><R><T><G><K><T><R><T><R><K><Q><V><S><S><H><I><Q><V><L><A><R><R><K><A><R><E><I><Q><A><K><L><K><D><Q><A><A><K><D><K><A><L><Q><S><M><A><A><M><S><S><A><Q><I><I><S><A><T><A><F><H><S><S><M><A><L><A><R><G><P><G><R><P><A><V><S><G><F><W><Q><G><A><L><P><G><Q><A><G><T><S><H><D><V><K><P><F><S><Q><Q><T><Y><A><V><Q><P><P><L><P><L><P><G><F><E><S><P><A><G><P><A><P><S><P><S><A><P><P><A><P><P><W><Q><G><R><S><V><A><S><S><K><L><W><M><L><E><F><S><A><F><L><E><Q><Q><Q><D><P><D><T><Y><N><K><H><L><F><V><H><I><G><Q><S><S><P><S><Y><S><D><P><Y><L><E><A><V><D><I><R><Q><I><Y><D><K><F><P><E><K><K><G><G><L><K><D><L><F><E><R><G><P><S><N><A><F><F><L><V><K><F><W><A><D><L><N><T><N><I><E><D><E><G><S><S><F><Y><G><V><S><S><Q><Y><E><S><P><E><N><M><I><I><T><C><S><T><K><V><C><S><F><G><K><Q><V><V><E><K><V><E><T><E><Y><A><R><Y><E><N><G><H><Y><S><Y><R><I><H><R><S><P><L><C><E><Y><M><I><N><F><I><H><K><L><K><H><L><P><E><K><Y><M><M><N><S><V><L><E><N><F><T><I><L><Q><V><V><T><N><R><D><T><Q><E><T><L><L><C><I><A><Y><V><F><E><V><S><A><S><E><H><G><A><Q><H><H><I><Y><R><L><V><K><E>
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.<BOP>
Q15561
Q14141
SEPT6_HUMAN
Septin-6
Homo
<M><A><A><T><D><I><A><R><Q><V><G><E><G><C><R><T><V><P><L><A><G><H><V><G><F><D><S><L><P><D><Q><L><V><N><K><S><V><S><Q><G><F><C><F><N><I><L><C><V><G><E><T><G><L><G><K><S><T><L><M><D><T><L><F><N><T><K><F><E><G><E><P><A><T><H><T><Q><P><G><V><Q><L><Q><S><N><T><Y><D><L><Q><E><S><N><V><R><L><K><L><T><I><V><S><T><V><G><F><G><D><Q><I><N><K><E><D><S><Y><K><P><I><V><E><F><I><D><A><Q><F><E><A><Y><L><Q><E><E><L><K><I><R><R><V><L><H><T><Y><H><D><S><R><I><H><V><C><L><Y><F><I><A><P><T><G><H><S><L><K><S><L><D><L><V><T><M><K><K><L><D><S><K><V><N><I><I><P><I><I><A><K><A><D><A><I><S><K><S><E><L><T><K><F><K><I><K><I><T><S><E><L><V><S><N><G><V><Q><I><Y><Q><F><P><T><D><D><E><S><V><A><E><I><N><G><T><M><N><A><H><L><P><F><A><V><I><G><S><T><E><E><L><K><I><G><N><K><M><M><R><A><R><Q><Y><P><W><G><T><V><Q><V><E><N><E><A><H><C><D><F><V><K><L><R><E><M><L><I><R><V><N><M><E><D><L><R><E><Q><T><H><T><R><H><Y><E><L><Y><R><R><C><K><L><E><E><M><G><F><K><D><T><D><P><D><S><K><P><F><S><L><Q><E><T><Y><E><A><K><R><N><E><F><L><G><E><L><Q><K><K><E><E><E><M><R><Q><M><F><V><Q><R><V><K><E><K><E><A><E><L><K><E><A><E><K><E><L><H><E><K><F><D><R><L><K><K><L><H><Q><D><E><K><K><K><L><E><D><K><K><K><S><L><D><D><E><V><N><A><F><K><Q><R><K><T><A><A><E><L><L><Q><S><Q><G><S><Q><A><G><G><S><Q><T><L><K><R><D><K><E><K><K><N><N><P><W><L><C><T><E>
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation .<BOP>
Q14141
P52741
ZN134_HUMAN
Zinc finger protein 134
Homo
<M><T><L><V><T><A><G><G><A><W><T><G><P><G><C><W><H><E><V><K><D><E><E><S><S><S><E><Q><S><I><S><I><A><V><S><H><V><N><T><S><K><A><G><L><P><A><Q><T><A><L><P><C><D><I><C><G><P><I><L><K><D><I><L><H><L><D><E><H><Q><G><T><H><H><G><L><K><L><H><T><C><G><A><C><G><R><Q><F><W><F><S><A><N><L><H><Q><Y><Q><K><C><Y><S><I><E><Q><P><L><R><R><D><K><S><E><A><S><I><V><K><N><C><T><V><S><K><E><P><H><P><S><E><K><P><F><T><C><K><E><E><Q><K><N><F><Q><A><T><L><G><G><C><Q><Q><K><A><I><H><S><K><R><K><T><H><R><S><T><E><S><G><D><A><F><H><G><E><Q><M><H><Y><K><C><S><E><C><G><K><A><F><S><R><K><D><T><L><V><Q><H><Q><R><I><H><S><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><S><R><K><A><T><L><V><Q><H><Q><R><I><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><T><F><S><R><K><D><N><L><T><Q><H><K><R><I><H><T><G><E><M><P><Y><K><C><N><E><C><G><K><Y><F><S><H><H><S><N><L><I><V><H><Q><R><V><H><N><G><A><R><P><Y><K><C><S><D><C><G><K><V><F><R><H><K><S><T><L><V><Q><H><E><S><I><H><T><G><E><N><P><Y><D><C><S><D><C><G><K><S><F><G><H><K><Y><T><L><I><K><H><Q><R><I><H><T><E><S><K><P><F><E><C><I><E><C><G><K><F><F><S><R><S><S><D><Y><I><A><H><Q><R><V><H><T><G><E><R><P><F><V><C><S><K><C><G><K><D><F><I><R><T><S><H><L><V><R><H><Q><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><A><Y><S><L><S><S><H><L><N><R><H><Q><K><V><H><T><A><G><R><L>
May be involved in transcriptional regulation.<BOP>
P52741
O43529
CHSTA_HUMAN
HNK-1 sulfotransferase
Homo
<M><H><H><Q><W><L><L><L><A><A><C><F><W><V><I><F><M><F><M><V><A><S><K><F><I><T><L><T><F><K><D><P><D><V><Y><S><A><K><Q><E><F><L><F><L><T><T><M><P><E><V><R><K><L><P><E><E><K><H><I><P><E><E><L><K><P><T><G><K><E><L><P><D><S><Q><L><V><Q><P><L><V><Y><M><E><R><L><E><L><I><R><N><V><C><R><D><D><A><L><K><N><L><S><H><T><P><V><S><K><F><V><L><D><R><I><F><V><C><D><K><H><K><I><L><F><C><Q><T><P><K><V><G><N><T><Q><W><K><K><V><L><I><V><L><N><G><A><F><S><S><I><E><E><I><P><E><N><V><V><H><D><H><E><K><N><G><L><P><R><L><S><S><F><S><D><A><E><I><Q><K><R><L><K><T><Y><F><K><F><F><I><V><R><D><P><F><E><R><L><I><S><A><F><K><D><K><F><V><H><N><P><R><F><E><P><W><Y><R><H><E><I><A><P><G><I><I><R><K><Y><R><R><N><R><T><E><T><R><G><I><Q><F><E><D><F><V><R><Y><L><G><D><P><N><H><R><W><L><D><L><Q><F><G><D><H><I><I><H><W><V><T><Y><V><E><L><C><A><P><C><E><I><M><Y><S><V><I><G><H><H><E><T><L><E><D><D><A><P><Y><I><L><K><E><A><G><I><D><H><L><V><S><Y><P><T><I><P><P><G><I><T><V><Y><N><R><T><K><V><E><H><Y><F><L><G><I><S><K><R><D><I><R><R><L><Y><A><R><F><E><G><D><F><K><L><F><G><Y><Q><K><P><D><F><L><L><N>
Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis . Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, confering binding specificity to extracellular matrix components . Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has
O43529
Q6P9G9
ZN449_HUMAN
Zinc finger and SCAN domain-containing protein 19
Homo
<M><A><V><A><L><G><C><A><I><Q><A><S><L><N><Q><G><S><V><F><Q><E><Y><D><T><D><C><E><V><F><R><Q><R><F><R><Q><F><Q><Y><R><E><A><A><G><P><H><E><A><F><N><K><L><W><E><L><C><C><Q><W><L><K><P><K><M><R><S><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><T><E><I><E><T><W><V><R><E><H><C><P><E><N><R><E><R><V><V><S><L><I><E><D><L><Q><R><E><L><E><I><P><E><Q><Q><V><D><M><H><D><M><L><L><E><E><L><A><P><V><G><T><A><H><I><P><P><T><M><H><L><E><S><P><A><L><Q><V><M><G><P><A><Q><E><A><P><V><A><E><A><W><I><P><Q><A><G><P><P><E><L><N><Y><G><A><T><G><E><C><Q><N><F><L><D><P><G><Y><P><L><P><K><L><D><M><N><F><S><L><E><N><R><E><E><P><W><V><K><E><L><Q><D><S><K><E><M><K><Q><L><L><D><S><K><I><G><F><E><I><G><I><E><N><E><E><D><T><S><K><Q><K><K><M><E><T><M><Y><P><F><I><V><T><L><E><G><N><A><L><Q><G><P><I><L><Q><K><D><Y><V><Q><L><E><N><Q><W><E><T><P><P><E><D><L><Q><T><D><L><A><K><L><V><D><Q><Q><N><P><T><L><G><E><T><P><E><N><S><N><L><E><E><P><L><N><P><K><P><H><K><K><K><S><P><G><E><K><P><H><R><C><P><Q><C><G><K><C><F><A><R><K><S><Q><L><T><G><H><Q><R><I><H><S><G><E><E><P><H><K><C><P><E><C><G><K><R><F><L><R><S><S><D><L><Y><R><H><Q><R><L><H><T><G><E><R><P><Y><E><C><T><V><C><K><K><R><F><T><R><R><S><H><L><I><G><H><Q><R><T><H><S><E><E><E><T><Y><K><C><L><E><C><G><K><S><F><C><H><G><S><S><L><K><R><H><L><K><T><H><T><G><E><K><P><H><R><C><H><N><C><G><K><S><F><S><R><L><T><A><L><T><L><H><Q><R><T><H><T><E><E><R><P><F><K><C><N><Y><C><G><K><S><F><R><Q><R><P><S><L><V><I><H><L><R><I><H><T><G><E><K><P><Y><K><C><T><H><C><S><K><S><F><R><Q><R><A><G><L><I><M><H><Q><V><T><H><F><R><G><L><I>
May be involved in transcriptional regulation.<BOP>
Q6P9G9
P22676
CALB2_HUMAN
29 kDa calbindin
Homo
<M><A><G><P><Q><Q><Q><P><P><Y><L><H><L><A><E><L><T><A><S><Q><F><L><E><I><W><K><H><F><D><A><D><G><N><G><Y><I><E><G><K><E><L><E><N><F><F><Q><E><L><E><K><A><R><K><G><S><G><M><M><S><K><S><D><N><F><G><E><K><M><K><E><F><M><Q><K><Y><D><K><N><S><D><G><K><I><E><M><A><E><L><A><Q><I><L><P><T><E><E><N><F><L><L><C><F><R><Q><H><V><G><S><S><A><E><F><M><E><A><W><R><K><Y><D><T><D><R><S><G><Y><I><E><A><N><E><L><K><G><F><L><S><D><L><L><K><K><A><N><R><P><Y><D><E><P><K><L><Q><E><Y><T><Q><T><I><L><R><M><F><D><L><N><G><D><G><K><L><G><L><S><E><M><S><R><L><L><P><V><Q><E><N><F><L><L><K><F><Q><G><M><K><L><T><S><E><E><F><N><A><I><F><T><F><Y><D><K><D><R><S><G><Y><I><D><E><H><E><L><D><A><L><L><K><D><L><Y><E><K><N><K><K><E><M><N><I><Q><Q><L><T><N><Y><R><K><S><V><M><S><L><A><E><A><G><K><L><Y><R><K><D><L><E><I><V><L><C><S><E><P><P><M>
Calretinin is a calcium-binding protein which is abundant in auditory neurons.<BOP>
P22676
Q7Z7J5
DPPA2_HUMAN
Pluripotent embryonic stem cell-related gene 1 protein
Homo
<M><S><D><A><N><L><D><S><S><K><K><N><F><L><E><G><E><V><D><D><E><E><S><V><I><L><T><L><V><P><V><K><D><D><A><N><M><E><Q><M><E><P><S><V><S><S><T><S><D><V><K><L><E><K><P><K><K><Y><N><P><G><H><L><L><Q><T><N><E><Q><F><T><A><P><Q><K><A><R><C><K><I><P><A><L><P><L><P><T><I><L><P><P><I><N><K><V><C><R><D><T><L><R><D><W><C><Q><Q><L><G><L><S><T><N><G><K><K><I><E><V><Y><L><R><L><H><R><H><A><Y><P><E><Q><R><Q><D><M><P><E><M><S><Q><E><T><R><L><Q><R><C><S><R><K><R><K><A><V><T><K><R><A><R><L><Q><R><S><Y><E><M><N><E><R><A><E><E><T><N><T><V><E><V><I><T><S><A><P><G><A><M><L><A><S><W><A><R><I><A><A><R><A><V><Q><P><K><A><L><N><S><C><S><I><P><V><S><V><E><A><F><L><M><Q><A><S><G><V><R><W><C><V><V><H><G><R><L><L><S><A><D><T><K><G><W><V><R><L><Q><F><H><A><G><Q><A><W><V><P><T><T><H><R><R><M><I><S><L><F><L><L><P><A><C><I><F><P><S><P><G><I><E><D><N><M><L><C><P><D><C><A><K><R><N><K><K><M><M><K><R><L><M><T><V><E><K>
Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.<BOP>
Q7Z7J5
Q8NGE1
OR6C4_HUMAN
Olfactory receptor OR12-10
Homo
<M><K><N><R><T><M><F><G><E><F><I><L><L><G><L><T><N><Q><P><E><L><Q><V><M><I><F><I><F><L><F><L><T><Y><M><L><S><I><L><G><N><L><T><I><I><T><L><T><L><L><D><P><H><L><Q><T><P><M><Y><F><F><L><R><N><F><S><F><L><E><I><S><F><T><S><I><F><I><P><R><F><L><T><S><M><T><T><G><N><K><V><I><S><F><A><G><C><L><T><Q><Y><F><F><A><I><F><L><G><A><T><E><F><Y><L><L><A><S><M><S><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><L><T><I><M><S><S><R><V><C><I><Q><L><V><F><C><S><W><L><G><G><F><L><A><I><L><P><P><I><I><L><M><T><Q><V><D><F><C><V><S><N><I><L><N><H><Y><Y><C><D><Y><G><P><L><V><E><L><A><C><S><D><T><S><L><L><E><L><M><V><I><L><L><A><V><V><T><L><M><V><T><L><V><L><V><T><L><S><Y><T><Y><I><I><R><T><I><L><R><I><P><S><A><Q><Q><R><T><K><A><F><S><T><C><S><S><H><M><I><V><I><S><L><S><Y><G><S><C><M><F><M><Y><I><N><P><S><A><K><E><G><G><A><F><N><K><G><I><A><V><L><I><T><S><V><T><P><L><L><N><P><F><I><Y><T><L><R><N><Q><Q><V><K><Q><A><F><K><D><S><V><K><K><I><V><K><L>
Odorant receptor.<BOP>
Q8NGE1
P20700
LMNB1_HUMAN
Lamin-B1
Homo
<M><A><T><A><T><P><V><P><P><R><M><G><S><R><A><G><G><P><T><T><P><L><S><P><T><R><L><S><R><L><Q><E><K><E><E><L><R><E><L><N><D><R><L><A><V><Y><I><D><K><V><R><S><L><E><T><E><N><S><A><L><Q><L><Q><V><T><E><R><E><E><V><R><G><R><E><L><T><G><L><K><A><L><Y><E><T><E><L><A><D><A><R><R><A><L><D><D><T><A><R><E><R><A><K><L><Q><I><E><L><G><K><C><K><A><E><H><D><Q><L><L><L><N><Y><A><K><K><E><S><D><L><N><G><A><Q><I><K><L><R><E><Y><E><A><A><L><N><S><K><D><A><A><L><A><T><A><L><G><D><K><K><S><L><E><G><D><L><E><D><L><K><D><Q><I><A><Q><L><E><A><S><L><A><A><A><K><K><Q><L><A><D><E><T><L><L><K><V><D><L><E><N><R><C><Q><S><L><T><E><D><L><E><F><R><K><S><M><Y><E><E><E><I><N><E><T><R><R><K><H><E><T><R><L><V><E><V><D><S><G><R><Q><I><E><Y><E><Y><K><L><A><Q><A><L><H><E><M><R><E><Q><H><D><A><Q><V><R><L><Y><K><E><E><L><E><Q><T><Y><H><A><K><L><E><N><A><R><L><S><S><E><M><N><T><S><T><V><N><S><A><R><E><E><L><M><E><S><R><M><R><I><E><S><L><S><S><Q><L><S><N><L><Q><K><E><S><R><A><C><L><E><R><I><Q><E><L><E><D><L><L><A><K><E><K><D><N><S><R><R><M><L><T><D><K><E><R><E><M><A><E><I><R><D><Q><M><Q><Q><Q><L><N><D><Y><E><Q><L><L><D><V><K><L><A><L><D><M><E><I><S><A><Y><R><K><L><L><E><G><E><E><E><R><L><K><L><S><P><S><P><S><S><R><V><T><V><S><R><A><S><S><S><R><S><V><R><T><T><R><G><K><R><K><R><V><D><V><E><E><S><E><A><S><S><S><V><S><I><S><H><S><A><S><A><T><G><N><V><C><I><E><E><I><D><V><D><G><K><F><I><R><L><K><N><T><S><E><Q><D><Q><P><M><G><G><W><E><M><I><R><K><I><G><D><T><S><V><S><Y><K><Y><T><S><R><Y><V><L><K><A><G><Q><T><V><T><I><W><A><A><N><A><G><V><T><A><S><P><P><T><D><L><I><W><K><N><Q><N><S><W><G><T><G><E><D><V><K><V><I><L><K><N><S><Q><G><E><E><V><A><Q><R><S><T><V><F><K><T><T><I><P><E><E><E><E><E><E><E><E><A><A><G><V><V><V><E><E><E><L><F><H><Q><Q><G><T><P><R><A><S><N><R><S><C><A><I><M>
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.<BOP>
P20700
Q9NWA0
MED9_HUMAN
Mediator complex subunit 9
Homo
<M><A><S><A><G><V><A><A><G><R><Q><A><E><D><V><L><P><P><T><S><D><Q><P><L><P><D><T><K><P><L><P><P><P><Q><P><P><P><V><P><A><P><Q><P><Q><Q><S><P><A><P><R><P><Q><S><P><A><R><A><R><E><E><E><N><Y><S><F><L><P><L><V><H><N><I><I><K><C><M><D><K><D><S><P><E><V><H><Q><D><L><N><A><L><K><S><K><F><Q><E><M><R><K><L><I><S><T><M><P><G><I><H><L><S><P><E><Q><Q><Q><Q><Q><L><Q><S><L><R><E><Q><V><R><T><K><N><E><L><L><Q><K><Y><K><S><L><C><M><F><E><I><P><K><E>
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP>
Q9NWA0
Q9Y6D9
MD1L1_HUMAN
Tax-binding protein 181
Homo
<M><E><D><L><G><E><N><T><M><V><L><S><T><L><R><S><L><N><N><F><I><S><Q><R><V><E><G><G><S><G><L><D><I><S><T><S><A><P><G><S><L><Q><M><Q><Y><Q><Q><S><M><Q><L><E><E><R><A><E><Q><I><R><S><K><S><H><L><I><Q><V><E><R><E><K><M><Q><M><E><L><S><H><K><R><A><R><V><E><L><E><R><A><A><S><T><S><A><R><N><Y><E><R><E><V><D><R><N><Q><E><L><L><T><R><I><R><Q><L><Q><E><R><E><A><G><A><E><E><K><M><Q><E><Q><L><E><R><N><R><Q><C><Q><Q><N><L><D><A><A><S><K><R><L><R><E><K><E><D><S><L><A><Q><A><G><E><T><I><N><A><L><K><G><R><I><S><E><L><Q><W><S><V><M><D><Q><E><M><R><V><K><R><L><E><S><E><K><Q><E><L><Q><E><Q><L><D><L><Q><H><K><K><C><Q><E><A><N><Q><K><I><Q><E><L><Q><A><S><Q><E><A><R><A><D><H><E><Q><Q><I><K><D><L><E><Q><K><L><S><L><Q><E><Q><D><A><A><I><V><K><N><M><K><S><E><L><V><R><L><P><R><L><E><R><E><L><K><Q><L><R><E><E><S><A><H><L><R><E><M><R><E><T><N><G><L><L><Q><E><E><L><E><G><L><Q><R><K><L><G><R><Q><E><K><M><Q><E><T><L><V><G><L><E><L><E><N><E><R><L><L><A><K><L><Q><S><W><E><R><L><D><Q><T><M><G><L><S><I><R><T><P><E><D><L><S><R><F><V><V><E><L><Q><Q><R><E><L><A><L><K><D><K><N><S><A><V><T><S><S><A><R><G><L><E><K><A><R><Q><Q><L><Q><E><E><L><R><Q><V><S><G><Q><L><L><E><E><R><K><K><R><E><T><H><E><A><L><A><R><R><L><Q><K><R><V><L><L><L><T><K><E><R><D><G><M><R><A><I><L><G><S><Y><D><S><E><L><T><P><A><E><Y><S><P><Q><L><T><R><R><M><R><E><A><E><D><M><V><Q><K><V><H><S><H><S><A><E><M><E><A><Q><L><S><Q><A><L><E><E><L><G><G><Q><K><Q><R><A><D><M><L><E><M><E><L><K><M><L><K><S><Q><S><S><S><A><E><Q><S><F><L><F><S><R><E><E><A><D><T><L><R><L><K><V><E><E><L><E><G><E><R><S><R><L><E><E><E><K><R><M><L><E><A><Q><L><E><R><R><A><L><Q><G><D><Y><D><Q><S><R><T><K><V><L><H><M><S><L><N><P><T><S><V><A><R><Q><R><L><R><E><D><H><S><Q><L><Q><A><E><C><E><R><L><R><G><L><L><R><A><M><E><R><G><G><T><V><P><A><D><L><E><A><A><A><A><S><L><P><S><S><K><E><V><A><E><L><K><K><Q><V><E><S><A><E><L><K><N><Q><R><L><K><E><V><F><Q><T><K><I><Q><E><F><R><K><A><C><Y><T><L><T><G><Y><Q><I><D><I><T><T><E><N><Q><Y><R><L><T><S><L><Y><A><E><H><P><G><D><C><L><I><F><K><A><T><S><P><S><G><S><K><M><Q><L><L><E><T><E><F><S><H><T><V><G><E><L><I><E><V><H><L><R><R><Q><D><S><I><P><A><F><L><S><S><L><T><L><E><L><F><S><R><Q><T><V><A>
Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas.<BOP>
Q9Y6D9