Split (3)

train · 7.69k rows

accession stringlengths 6 10	name stringlengths 8 11	Full Name stringlengths 2 102 ⌀	taxon stringclasses 1 value	sequence stringlengths 48 2.3k	function stringlengths 15 1.34k	AlphaFoldDB stringlengths 6 10
Q6AZW8	ZN660_HUMAN	Zinc finger protein 660	Homo	<M><R><R><K><T><R><N><F><K><H><K><T><V><K><D><N><K><V><L><T><E><G><S><D><Q><E><S><E><K><D><N><S><Q><C><C><D><P><A><T><N><E><R><V><Q><A><E><K><R><Q><Y><V><C><T><E><C><G><K><A><F><S><Q><S><A><N><L><T><V><H><E><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><S><H><S><S><N><L><V><V><H><R><R><I><H><T><G><L><K><P><Y><T><C><S><E><C><G><K><S><F><S><G><K><S><H><L><I><R><H><Q><G><I><H><S><G><E><K><T><Y><E><C><K><E><C><G><K><A><F><S><R><S><S><G><L><I><S><H><H><R><V><H><T><G><E><K><P><Y><S><C><I><E><C><G><K><A><F><S><R><S><S><N><L><T><Q><H><Q><R><M><H><R><G><K><K><V><Y><K><C><K><E><C><G><K><T><C><G><S><N><T><K><I><M><D><H><Q><R><I><H><T><G><E><K><P><Y><E><C><D><E><C><G><K><T><F><I><L><R><K><T><L><N><E><H><Q><R><L><H><R><R><E><K><P><Y><K><C><N><E><C><G><K><A><F><T><S><N><R><N><L><V><D><H><Q><R><V><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><R><Q><T><S><Q><V><I><L><H><L><R><T><H><T><K><E><K><P><Y><K><C><S><E><C><G><K><A><Y><R><Y><S><S><Q><L><I><Q><H><Q><R><K><H><N><E><E><K><E><T><S>	May be involved in transcriptional regulation.<BOP>	Q6AZW8
Q01362	FCERB_HUMAN	Membrane-spanning 4-domains subfamily A member 2	Homo	<M><D><T><E><S><N><R><R><A><N><L><A><L><P><Q><E><P><S><S><V><P><A><F><E><V><L><E><I><S><P><Q><E><V><S><S><G><R><L><L><K><S><A><S><S><P><P><L><H><T><W><L><T><V><L><K><K><E><Q><E><F><L><G><V><T><Q><I><L><T><A><M><I><C><L><C><F><G><T><V><V><C><S><V><L><D><I><S><H><I><E><G><D><I><F><S><S><F><K><A><G><Y><P><F><W><G><A><I><F><F><S><I><S><G><M><L><S><I><I><S><E><R><R><N><A><T><Y><L><V><R><G><S><L><G><A><N><T><A><S><S><I><A><G><G><T><G><I><T><I><L><I><I><N><L><K><K><S><L><A><Y><I><H><I><H><S><C><Q><K><F><F><E><T><K><C><F><M><A><S><F><S><T><E><I><V><V><M><M><L><F><L><T><I><L><G><L><G><S><A><V><S><L><T><I><C><G><A><G><E><E><L><K><G><N><K><V><P><E><D><R><V><Y><E><E><L><N><I><Y><S><A><T><Y><S><E><L><E><D><P><G><E><M><S><P><P><I><D><L>	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.<BOP>	Q01362
Q3LI64	KRA61_HUMAN	Keratin-associated protein 6-1	Homo	<M><C><G><S><Y><Y><G><N><Y><Y><G><T><P><G><Y><G><F><C><G><Y><G><G><L><G><Y><G><Y><G><G><L><G><C><G><Y><G><S><C><C><G><C><G><F><R><R><L><G><C><G><Y><G><Y><G><S><R><S><L><C><G><Y><G><Y><G><C><G><S><G><S><G><Y><Y><Y>	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>	Q3LI64
Q9Y4C5	CHST2_HUMAN	N-acetylglucosamine 6-O-sulfotransferase 1	Homo	<M><S><R><S><P><Q><R><A><L><P><P><G><A><L><P><R><L><L><Q><A><A><P><A><A><A><P><R><A><L><L><P><Q><W><P><R><R><P><G><R><R><W><P><A><S><P><L><G><M><K><V><F><R><R><K><A><L><V><L><C><A><G><Y><A><L><L><L><V><L><T><M><L><N><L><L><D><Y><K><W><H><K><E><P><L><Q><Q><C><N><P><D><G><P><L><G><A><A><A><G><A><A><G><G><S><W><G><R><P><G><P><P><P><A><G><P><P><R><A><H><A><R><L><D><L><R><T><P><Y><R><P><P><A><A><A><V><G><A><A><P><A><A><A><A><G><M><A><G><V><A><A><P><P><G><N><G><T><R><G><T><G><G><V><G><D><K><R><Q><L><V><Y><V><F><T><T><W><R><S><G><S><S><F><F><G><E><L><F><N><Q><N><P><E><V><F><F><L><Y><E><P><V><W><H><V><W><Q><K><L><Y><P><G><D><A><V><S><L><Q><G><A><A><R><D><M><L><S><A><L><Y><R><C><D><L><S><V><F><Q><L><Y><S><P><A><G><S><G><G><R><N><L><T><T><L><G><I><F><G><A><A><T><N><K><V><V><C><S><S><P><L><C><P><A><Y><R><K><E><V><V><G><L><V><D><D><R><V><C><K><K><C><P><P><Q><R><L><A><R><F><E><E><E><C><R><K><Y><R><T><L><V><I><K><G><V><R><V><F><D><V><A><V><L><A><P><L><L><R><D><P><A><L><D><L><K><V><I><H><L><V><R><D><P><R><A><V><A><S><S><R><I><R><S><R><H><G><L><I><R><E><S><L><Q><V><V><R><S><R><D><P><R><A><H><R><M><P><F><L><E><A><A><G><H><K><L><G><A><K><K><E><G><V><G><G><P><A><D><Y><H><A><L><G><A><M><E><V><I><C><N><S><M><A><K><T><L><Q><T><A><L><Q><P><P><D><W><L><Q><G><H><Y><L><V><V><R><Y><E><D><L><V><G><D><P><V><K><T><L><R><R><V><Y><D><F><V><G><L><L><V><S><P><E><M><E><Q><F><A><L><N><M><T><S><G><S><G><S><S><S><K><P><F><V><V><S><A><R><N><A><T><Q><A><A><N><A><W><R><T><A><L><T><F><Q><Q><I><K><Q><V><E><E><F><C><Y><Q><P><M><A><V><L><G><Y><E><R><V><N><S><P><E><E><V><K><D><L><S><K><T><L><L><R><K><P><R><L>	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.<BOP>	Q9Y4C5
Q6ZVX7	FBX50_HUMAN	Non-specific cytotoxic cell receptor protein 1 homolog	Homo	<M><E><E><V><R><E><G><H><A><L><G><G><G><M><E><A><D><G><P><A><S><L><Q><E><L><P><P><S><P><R><S><P><S><P><P><P><S><P><P><P><L><P><S><P><P><S><L><P><S><P><A><A><P><E><A><P><E><L><P><E><P><A><Q><P><S><E><A><H><A><R><Q><L><L><L><E><E><W><G><P><L><S><G><G><L><E><L><P><Q><R><L><T><W><K><L><L><L><L><R><R><P><L><Y><R><N><L><L><R><S><P><N><P><E><G><I><N><I><Y><E><P><A><P><P><T><G><P><T><Q><R><P><L><E><T><L><G><N><F><R><G><W><Y><I><R><T><E><K><L><Q><Q><N><Q><S><W><T><V><K><Q><Q><C><V><D><L><L><A><E><G><L><W><E><E><L><L><D><D><E><Q><P><A><I><T><V><M><D><W><F><E><D><S><R><L><D><A><C><V><Y><E><L><H><V><W><L><L><A><A><D><R><R><T><V><I><A><Q><H><H><V><A><P><R><T><S><G><R><G><P><P><G><R><W><V><Q><V><S><H><V><F><R><H><Y><G><P><G><V><R><F><I><H><F><L><H><K><A><K><N><R><M><E><P><G><G><L><R><R><T><R><V><T><D><S><S><V><S><V><Q><L><R><E>	Promotes cell proliferation.<BOP>	Q6ZVX7
A0A0A0MRZ7	KVD26_HUMAN	Immunoglobulin kappa variable 2D-26	Homo	<M><R><L><P><A><Q><L><L><G><L><L><M><L><W><V><P><G><S><S><A><E><I><V><M><T><Q><T><P><L><S><L><S><I><T><P><G><E><Q><A><S><M><S><C><R><S><S><Q><S><L><L><H><S><D><G><Y><T><Y><L><Y><W><F><L><Q><K><A><R><P><V><S><T><L><L><I><Y><E><V><S><N><R><F><S><G><V><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><K><I><S><R><V><E><A><E><D><F><G><V><Y><Y><C><M><Q><D><A><Q><D><P>	V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>	A0A0A0MRZ7
Q6V9R5	ZN562_HUMAN	Zinc finger protein 562	Homo	<M><S><A><F><D><M><S><H><G><F><F><P><R><E><P><I><C><P><F><E><E><K><T><K><I><G><T><M><V><E><D><H><R><S><N><S><Y><Q><D><S><V><T><F><D><D><V><A><V><E><F><T><P><E><E><W><A><L><L><D><T><T><Q><K><Y><L><Y><R><D><V><M><L><E><N><Y><M><N><L><A><S><V><D><F><F><F><C><L><T><S><E><W><E><I><Q><P><R><T><K><R><S><S><L><Q><Q><G><F><L><K><N><Q><I><F><T><G><I><Q><M><Q><T><R><S><Y><S><G><W><K><L><C><E><N><C><G><E><V><F><S><E><Q><F><C><L><K><T><H><M><R><A><Q><N><G><G><N><T><F><E><G><N><C><Y><G><K><D><S><I><S><V><H><K><E><A><S><I><G><Q><E><L><S><K><F><N><P><C><G><K><V><F><T><L><T><P><G><L><A><V><H><L><E><I><L><N><G><R><Q><P><Y><K><C><K><E><C><G><K><G><F><K><Y><F><A><S><L><D><N><H><M><G><I><H><I><G><E><K><L><C><E><F><Q><E><C><E><R><A><I><T><T><S><S><H><L><K><Q><C><V><A><V><H><T><G><K><K><S><E><K><T><K><N><C><G><K><S><F><T><N><F><S><Q><L><S><A><H><A><K><T><H><K><G><E><K><S><F><E><C><K><E><C><G><R><S><F><R><N><S><S><S><F><N><V><H><I><Q><I><H><T><G><I><K><P><H><K><C><T><E><C><G><K><A><F><T><R><S><T><H><L><T><Q><H><V><R><T><H><T><G><I><K><P><Y><E><C><K><E><C><G><Q><A><F><T><Q><Y><T><G><L><A><I><H><I><R><N><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><N><R><S><S><T><L><T><Q><H><R><R><I><H><T><G><E><K><P><Y><E><C><V><E><C><G><K><T><F><I><T><S><S><H><R><S><K><H><L><K><T><H><S><G><E><R>	May be involved in transcriptional regulation.<BOP>	Q6V9R5
P0CJ71	HMN4_HUMAN	MT-RNR2-like protein 4	Homo	<M><A><T><Q><G><F><S><C><L><L><L><S><V><S><E><I><D><L><S><M><K><R><Q><Y><K><Q><I><R>	Plays a role as a neuroprotective and antiapoptotic factor.<BOP>	P0CJ71
P06744	G6PI_HUMAN	Sperm antigen 36	Homo	<M><A><A><L><T><R><D><P><Q><F><Q><K><L><Q><Q><W><Y><R><E><H><R><S><E><L><N><L><R><R><L><F><D><A><N><K><D><R><F><N><H><F><S><L><T><L><N><T><N><H><G><H><I><L><V><D><Y><S><K><N><L><V><T><E><D><V><M><R><M><L><V><D><L><A><K><S><R><G><V><E><A><A><R><E><R><M><F><N><G><E><K><I><N><Y><T><E><G><R><A><V><L><H><V><A><L><R><N><R><S><N><T><P><I><L><V><D><G><K><D><V><M><P><E><V><N><K><V><L><D><K><M><K><S><F><C><Q><R><V><R><S><G><D><W><K><G><Y><T><G><K><T><I><T><D><V><I><N><I><G><I><G><G><S><D><L><G><P><L><M><V><T><E><A><L><K><P><Y><S><S><G><G><P><R><V><W><Y><V><S><N><I><D><G><T><H><I><A><K><T><L><A><Q><L><N><P><E><S><S><L><F><I><I><A><S><K><T><F><T><T><Q><E><T><I><T><N><A><E><T><A><K><E><W><F><L><Q><A><A><K><D><P><S><A><V><A><K><H><F><V><A><L><S><T><N><T><T><K><V><K><E><F><G><I><D><P><Q><N><M><F><E><F><W><D><W><V><G><G><R><Y><S><L><W><S><A><I><G><L><S><I><A><L><H><V><G><F><D><N><F><E><Q><L><L><S><G><A><H><W><M><D><Q><H><F><R><T><T><P><L><E><K><N><A><P><V><L><L><A><L><L><G><I><W><Y><I><N><C><F><G><C><E><T><H><A><M><L><P><Y><D><Q><Y><L><H><R><F><A><A><Y><F><Q><Q><G><D><M><E><S><N><G><K><Y><I><T><K><S><G><T><R><V><D><H><Q><T><G><P><I><V><W><G><E><P><G><T><N><G><Q><H><A><F><Y><Q><L><I><H><Q><G><T><K><M><I><P><C><D><F><L><I><P><V><Q><T><Q><H><P><I><R><K><G><L><H><H><K><I><L><L><A><N><F><L><A><Q><T><E><A><L><M><R><G><K><S><T><E><E><A><R><K><E><L><Q><A><A><G><K><S><P><E><D><L><E><R><L><L><P><H><K><V><F><E><G><N><R><P><T><N><S><I><V><F><T><K><L><T><P><F><M><L><G><A><L><V><A><M><Y><E><H><K><I><F><V><Q><G><I><I><W><D><I><N><S><F><D><Q><W><G><V><E><L><G><K><Q><L><A><K><K><I><E><P><E><L><D><G><S><A><Q><V><T><S><H><D><A><S><T><N><G><L><I><N><F><I><K><Q><Q><R><E><A><R><V><Q>	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis . Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility . Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons . It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion .<BOP>	P06744
O43506	ADA20_HUMAN	Disintegrin and metalloproteinase domain-containing protein 20	Homo	<M><A><V><G><E><P><L><V><H><I><R><V><T><L><L><L><L><W><F><G><M><F><L><S><I><S><G><H><S><Q><A><R><P><S><Q><Y><F><T><S><P><E><V><V><I><P><L><K><V><I><S><R><G><R><G><A><K><A><P><G><W><L><S><Y><S><L><R><F><G><G><Q><R><Y><I><V><H><M><R><V><N><K><L><L><F><A><A><H><L><P><V><F><T><Y><T><E><Q><H><A><L><L><Q><D><Q><P><F><I><Q><D><D><C><Y><Y><H><G><Y><V><E><G><V><P><E><S><L><V><A><L><S><T><C><S><G><G><F><L><G><M><L><Q><I><N><D><L><V><Y><E><I><K><P><I><S><V><S><A><T><F><E><H><L><V><Y><K><I><D><S><D><D><T><Q><F><P><P><M><R><C><G><L><T><E><E><K><I><A><H><Q><M><E><L><Q><L><S><Y><N><F><T><L><K><Q><S><S><F><V><G><W><W><T><H><Q><R><F><V><E><L><V><V><V><V><D><N><I><R><Y><L><F><S><Q><S><N><A><T><T><V><Q><H><E><V><F><N><V><V><N><I><V><D><S><F><Y><H><P><L><E><V><D><V><I><L><T><G><I><D><I><W><T><A><S><N><P><L><P><T><S><G><D><L><D><N><V><L><E><D><F><S><I><W><K><N><Y><N><L><N><N><R><L><Q><H><D><V><A><H><L><F><I><K><D><T><Q><G><M><K><L><G><V><A><Y><V><K><G><I><C><Q><N><P><F><N><T><G><V><D><V><F><E><D><N><R><L><V><V><F><A><I><T><L><G><H><E><L><G><H><N><L><G><M><Q><H><D><T><Q><W><C><V><C><E><L><Q><W><C><I><M><H><A><Y><R><K><V><T><T><K><F><S><N><C><S><Y><A><Q><Y><W><D><S><T><I><S><S><G><L><C><I><Q><P><P><P><Y><P><G><N><I><F><R><L><K><Y><C><G><N><L><V><V><E><E><G><E><E><C><D><C><G><T><I><R><Q><C><A><K><D><P><C><C><L><L><N><C><T><L><H><P><G><A><A><C><A><F><G><I><C><C><K><D><C><K><F><L><P><S><G><T><L><C><R><Q><Q><V><G><E><C><D><L><P><E><W><C><N><G><T><S><H><Q><C><P><D><D><V><Y><V><Q><D><G><I><S><C><N><V><N><A><F><C><Y><E><K><T><C><N><N><H><D><I><Q><C><K><E><I><F><G><Q><D><A><R><S><A><S><Q><S><C><Y><Q><E><I><N><T><Q><G><N><R><F><G><H><C><G><I><V><G><T><T><Y><V><K><C><W><T><P><D><I><M><C><G><R><V><Q><C><E><N><V><G><V><I><P><N><L><I><E><H><S><T><V><Q><Q><F><H><L><N><D><T><T><C><W><G><T><D><Y><H><L><G><M><A><I><P><D><I><G><E><V><K><D><G><T><V><C><G><P><E><K><I><C><I><R><K><K><C><A><S><M><V><H><L><S><Q><A><C><Q><P><K><T><C><N><M><R><G><I><C><N><N><K><Q><H><C><H><C><N><H><E><W><A><P><P><Y><C><K><D><K><G><Y><G><G><S><A><D><S><G><P><P><P><K><N><N><M><E><G><L><N><V><M><G><K><L><R><Y><L><S><L><L><C><L><L><P><L><V><A><F><L><L><F><C><L><H><V><L><F><K><K><R><T><K><S><K><E><D><E><E><G>	May be involved in sperm maturation and/or fertilization.<BOP>	O43506
Q9NWN3	FBX34_HUMAN	F-box only protein 34	Homo	<M><H><L><K><P><Y><W><K><L><Q><K><K><E><H><P><P><E><V><S><R><E><T><Q><R><T><P><M><N><H><Q><K><A><V><N><D><E><T><C><K><A><S><H><I><T><S><S><V><F><P><S><A><S><L><G><K><A><S><S><R><K><P><F><G><I><L><S><P><N><V><L><C><S><M><S><G><K><S><P><V><E><S><S><L><N><V><K><T><K><K><N><A><P><S><A><T><I><H><Q><G><E><E><E><G><P><L><D><I><W><A><V><V><K><P><G><N><T><K><E><K><I><A><F><F><A><S><H><Q><C><S><N><R><I><G><S><M><K><I><K><S><S><W><D><I><D><G><R><A><T><K><R><R><K><K><S><G><D><L><K><K><A><K><V><Q><V><E><R><M><R><E><V><N><S><R><C><Y><Q><P><E><P><F><A><C><G><I><E><H><C><S><V><H><Y><V><S><D><S><G><D><G><V><Y><A><G><R><P><L><S><V><I><Q><M><V><A><F><L><E><Q><R><A><S><A><L><L><A><S><C><S><K><N><C><T><N><S><P><A><I><V><R><F><S><G><Q><S><R><G><V><P><A><V><S><E><S><Y><S><A><P><G><A><C><E><E><P><T><E><R><G><N><L><E><V><G><E><P><Q><S><E><P><V><R><V><L><D><M><V><A><K><L><E><S><E><C><L><K><R><Q><G><Q><R><E><P><G><S><L><S><R><N><N><S><F><R><R><N><V><G><R><V><L><L><A><N><S><T><Q><A><D><E><G><K><T><K><K><G><V><L><E><A><P><D><T><Q><V><N><P><V><G><S><V><S><V><D><C><G><P><S><R><A><D><R><C><S><P><K><E><D><Q><A><W><D><G><A><S><Q><D><C><P><P><L><P><A><G><V><S><F><H><I><D><S><A><E><L><E><P><G><S><Q><T><A><V><K><N><S><N><R><Y><D><V><E><M><T><D><E><L><V><G><L><P><F><S><S><H><T><Y><S><Q><A><S><E><L><P><T><D><A><V><D><C><M><S><R><E><L><V><S><L><T><S><R><N><P><D><Q><R><K><E><S><L><C><I><S><I><T><V><S><K><V><D><K><D><Q><P><S><I><L><N><S><C><E><D><P><V><P><G><M><L><F><F><L><P><P><G><Q><H><L><S><D><Y><S><Q><L><N><E><S><T><T><K><E><S><S><E><A><S><Q><L><E><D><A><A><G><G><D><S><A><S><E><E><K><S><G><S><A><E><P><F><V><L><P><A><S><S><V><E><S><T><L><P><V><L><E><A><S><S><W><K><K><Q><V><S><H><D><F><L><E><T><R><F><K><I><Q><Q><L><L><E><P><Q><Q><Y><M><A><F><L><P><H><H><I><M><V><K><I><F><R><L><L><P><T><K><S><L><V><A><L><K><C><T><C><C><Y><F><K><F><I><I><E><Y><Y><N><I><R><P><A><D><S><R><W><V><R><D><P><R><Y><R><E><D><P><C><K><Q><C><K><K><K><Y><V><K><G><D><V><S><L><C><R><W><H><P><K><P><Y><C><Q><A><L><P><Y><G><P><G><Y><W><M><C><C><H><R><S><Q><K><G><F><P><G><C><K><L><G><L><H><D><N><H><W><V><P><A><C><H><S><F><N><R><A><I><H><K><K><A><K><G><T><E><A><E><E><E><Y>	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>	Q9NWN3
P08173	ACM4_HUMAN	Muscarinic acetylcholine receptor M4	Homo	<M><A><N><F><T><P><V><N><G><S><S><G><N><Q><S><V><R><L><V><T><S><S><S><H><N><R><Y><E><T><V><E><M><V><F><I><A><T><V><T><G><S><L><S><L><V><T><V><V><G><N><I><L><V><M><L><S><I><K><V><N><R><Q><L><Q><T><V><N><N><Y><F><L><F><S><L><A><C><A><D><L><I><I><G><A><F><S><M><N><L><Y><T><V><Y><I><I><K><G><Y><W><P><L><G><A><V><V><C><D><L><W><L><A><L><D><Y><V><V><S><N><A><S><V><M><N><L><L><I><I><S><F><D><R><Y><F><C><V><T><K><P><L><T><Y><P><A><R><R><T><T><K><M><A><G><L><M><I><A><A><A><W><V><L><S><F><V><L><W><A><P><A><I><L><F><W><Q><F><V><V><G><K><R><T><V><P><D><N><Q><C><F><I><Q><F><L><S><N><P><A><V><T><F><G><T><A><I><A><A><F><Y><L><P><V><V><I><M><T><V><L><Y><I><H><I><S><L><A><S><R><S><R><V><H><K><H><R><P><E><G><P><K><E><K><K><A><K><T><L><A><F><L><K><S><P><L><M><K><Q><S><V><K><K><P><P><P><G><E><A><A><R><E><E><L><R><N><G><K><L><E><E><A><P><P><P><A><L><P><P><P><P><R><P><V><A><D><K><D><T><S><N><E><S><S><S><G><S><A><T><Q><N><T><K><E><R><P><A><T><E><L><S><T><T><E><A><T><T><P><A><M><P><A><P><P><L><Q><P><R><A><L><N><P><A><S><R><W><S><K><I><Q><I><V><T><K><Q><T><G><N><E><C><V><T><A><I><E><I><V><P><A><T><P><A><G><M><R><P><A><A><N><V><A><R><K><F><A><S><I><A><R><N><Q><V><R><K><K><R><Q><M><A><A><R><E><R><K><V><T><R><T><I><F><A><I><L><L><A><F><I><L><T><W><T><P><Y><N><V><M><V><L><V><N><T><F><C><Q><S><C><I><P><D><T><V><W><S><I><G><Y><W><L><C><Y><V><N><S><T><I><N><P><A><C><Y><A><L><C><N><A><T><F><K><K><T><F><R><H><L><L><L><C><Q><Y><R><N><I><G><T><A><R>	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.<BOP>	P08173
Q53RD9	FBLN7_HUMAN	Fibulin-7	Homo	<M><V><P><S><S><P><R><A><L><F><L><L><L><L><I><L><A><C><P><E><P><R><A><S><Q><N><C><L><S><K><Q><Q><L><L><S><A><I><R><Q><L><Q><Q><L><L><K><G><Q><E><T><R><F><A><E><G><I><R><H><M><K><S><R><L><A><A><L><Q><N><S><V><G><R><V><G><P><D><A><L><P><V><S><C><P><A><L><N><T><P><A><D><G><R><K><F><G><S><K><Y><L><V><D><H><E><V><H><F><T><C><N><P><G><F><R><L><V><G><P><S><S><V><V><C><L><P><N><G><T><W><T><G><E><Q><P><H><C><R><G><I><S><E><C><S><S><Q><P><C><Q><N><G><G><T><C><V><E><G><V><N><Q><Y><R><C><I><C><P><P><G><R><T><G><N><R><C><Q><H><Q><A><Q><T><A><A><P><E><G><S><V><A><G><D><S><A><F><S><R><A><P><R><C><A><Q><V><E><R><A><Q><H><C><S><C><E><A><G><F><H><L><S><G><A><A><G><D><S><V><C><Q><D><V><N><E><C><E><L><Y><G><Q><E><G><R><P><R><L><C><M><H><A><C><V><N><T><P><G><S><Y><R><C><T><C><P><G><G><Y><R><T><L><A><D><G><K><S><C><E><D><V><D><E><C><V><G><L><Q><P><V><C><P><Q><G><T><T><C><I><N><T><G><G><S><F><Q><C><V><S><P><E><C><P><E><G><S><G><N><V><S><Y><V><K><T><S><P><F><Q><C><E><R><N><P><C><P><M><D><S><R><P><C><R><H><L><P><K><T><I><S><F><H><Y><L><S><L><P><S><N><L><K><T><P><I><T><L><F><R><M><A><T><A><S><A><P><G><R><A><G><P><N><S><L><R><F><G><I><V><G><G><N><S><R><G><H><F><V><M><Q><R><S><D><R><Q><T><G><D><L><I><L><V><Q><N><L><E><G><P><Q><T><L><E><V><D><V><D><M><S><E><Y><L><D><R><S><F><Q><A><N><H><V><S><K><V><T><I><F><V><S><P><Y><D><F>	An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation.<BOP>	Q53RD9
O43294	TGFI1_HUMAN	Hydrogen peroxide-inducible clone 5 protein	Homo	<M><E><D><L><D><A><L><L><S><D><L><E><T><T><T><S><H><M><P><R><S><G><A><P><K><E><R><P><A><E><P><L><T><P><P><P><S><Y><G><H><Q><P><Q><T><G><S><G><E><S><S><G><A><S><G><D><K><D><H><L><Y><S><T><V><C><K><P><R><S><P><K><P><A><A><P><A><A><P><P><F><S><S><S><S><G><V><L><G><T><G><L><C><E><L><D><R><L><L><Q><E><L><N><A><T><Q><F><N><I><T><D><E><I><M><S><Q><F><P><S><S><K><V><A><S><G><E><Q><K><E><D><Q><S><E><D><K><K><R><P><S><L><P><S><S><P><S><P><G><L><P><K><A><S><A><T><S><A><T><L><E><L><D><R><L><M><A><S><L><S><D><F><R><V><Q><N><H><L><P><A><S><G><P><T><Q><P><P><V><V><S><S><T><N><E><G><S><P><S><P><P><E><P><T><G><K><G><S><L><D><T><M><L><G><L><L><Q><S><D><L><S><R><R><G><V><P><T><Q><A><K><G><L><C><G><S><C><N><K><P><I><A><G><Q><V><V><T><A><L><G><R><A><W><H><P><E><H><F><V><C><G><G><C><S><T><A><L><G><G><S><S><F><F><E><K><D><G><A><P><F><C><P><E><C><Y><F><E><R><F><S><P><R><C><G><F><C><N><Q><P><I><R><H><K><M><V><T><A><L><G><T><H><W><H><P><E><H><F><C><C><V><S><C><G><E><P><F><G><D><E><G><F><H><E><R><E><G><R><P><Y><C><R><R><D><F><L><Q><L><F><A><P><R><C><Q><G><C><Q><G><P><I><L><D><N><Y><I><S><A><L><S><A><L><W><H><P><D><C><F><V><C><R><E><C><F><A><P><F><S><G><G><S><F><F><E><H><E><G><R><P><L><C><E><N><H><F><H><A><R><R><G><S><L><C><A><T><C><G><L><P><V><T><G><R><C><V><S><A><L><G><R><R><F><H><P><D><H><F><T><C><T><F><C><L><R><P><L><T><K><G><S><F><Q><E><R><A><G><K><P><Y><C><Q><P><C><F><L><K><L><F><G>	Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.<BOP>	O43294
P16415	ZN823_HUMAN	Zinc finger protein ZFP-36	Homo	<M><D><S><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><G><P><S><Q><K><S><L><Y><R><N><V><M><Q><E><T><I><R><N><L><D><C><I><E><M><K><W><E><D><Q><N><I><G><D><Q><C><Q><N><A><K><R><N><L><R><S><H><T><C><E><I><K><D><D><S><Q><C><G><E><T><F><G><Q><I><P><D><S><I><V><N><K><N><T><P><R><V><N><P><C><D><S><G><E><C><G><E><V><V><L><G><H><S><S><L><N><C><N><I><R><V><D><T><G><H><K><S><C><E><H><Q><E><Y><G><E><K><P><Y><T><H><K><Q><R><G><K><A><I><S><H><Q><H><S><F><Q><T><H><E><R><P><P><T><G><K><K><P><F><D><C><K><E><C><A><K><T><F><S><S><L><G><N><L><R><R><H><M><A><A><H><H><G><D><G><P><Y><K><C><K><L><C><G><K><A><F><V><W><P><S><L><F><H><L><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><S><K><A><F><P><F><Y><S><S><Y><L><R><H><E><R><I><H><T><G><E><K><A><Y><E><C><K><Q><C><S><K><A><F><P><D><Y><S><T><Y><L><R><H><E><R><T><H><T><G><E><K><P><Y><K><C><T><Q><C><G><K><A><F><S><C><Y><Y><Y><T><R><L><H><E><R><T><H><T><G><E><Q><P><Y><A><C><K><Q><C><G><K><T><F><Y><H><H><T><S><F><R><R><H><M><I><R><H><T><G><D><G><P><H><K><C><K><I><C><G><K><G><F><D><C><P><S><S><V><R><N><H><E><T><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><V><L><S><H><S><S><S><F><R><S><H><M><I><T><H><T><G><D><G><P><Q><K><C><K><I><C><G><K><A><F><G><C><P><S><L><F><Q><R><H><E><R><T><H><T><G><E><K><P><Y><Q><C><K><Q><C><G><K><A><F><S><L><A><G><S><L><R><R><H><E><A><T><H><T><G><V><K><P><Y><K><C><Q><C><G><K><A><F><S><D><L><S><S><F><Q><N><H><E><T><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><C><F><K><Y><L><S><Q><H><K><R><T><H><T><V><E><K><P><Y><E><C><K><T><C><R><K><A><F><S><H><F><S><N><L><K><V><H><E><R><I><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><W><L><T><C><L><L><R><H><E><R><I><H><T><G><E><K><P><Y><E><C><L><Q><C><G><K><A><F><T><R><S><R><F><L><R><G><H><E><K><T><H><T><G><E><K><L><Y><E><C><K><E><C><G><K><A><L><S><S><L><R><S><L><H><R><H><K><R><T><H><W><K><D><T><L>	May be involved in transcriptional regulation.<BOP>	P16415
P42681	TXK_HUMAN	Resting lymphocyte kinase	Homo	<M><I><L><S><S><Y><N><T><I><Q><S><V><F><C><C><C><C><C><C><S><V><Q><K><R><Q><M><R><T><Q><I><S><L><S><T><D><E><E><L><P><E><K><Y><T><Q><R><R><R><P><W><L><S><Q><L><S><N><K><K><Q><S><N><T><G><R><V><Q><P><S><K><R><K><P><L><P><P><L><P><P><S><E><V><A><E><E><K><I><Q><V><K><A><L><Y><D><F><L><P><R><E><P><C><N><L><A><L><R><R><A><E><E><Y><L><I><L><E><K><Y><N><P><H><W><W><K><A><R><D><R><L><G><N><E><G><L><I><P><S><N><Y><V><T><E><N><K><I><T><N><L><E><I><Y><E><W><Y><H><R><N><I><T><R><N><Q><A><E><H><L><L><R><Q><E><S><K><E><G><A><F><I><V><R><D><S><R><H><L><G><S><Y><T><I><S><V><F><M><G><A><R><R><S><T><E><A><A><I><K><H><Y><Q><I><K><K><N><D><S><G><Q><W><Y><V><A><E><R><H><A><F><Q><S><I><P><E><L><I><W><Y><H><Q><H><N><A><A><G><L><M><T><R><L><R><Y><P><V><G><L><M><G><S><C><L><P><A><T><A><G><F><S><Y><E><K><W><E><I><D><P><S><E><L><A><F><I><K><E><I><G><S><G><Q><F><G><V><V><H><L><G><E><W><R><S><H><I><Q><V><A><I><K><A><I><N><E><G><S><M><S><E><E><D><F><I><E><E><A><K><V><M><M><K><L><S><H><S><K><L><V><Q><L><Y><G><V><C><I><Q><R><K><P><L><Y><I><V><T><E><F><M><E><N><G><C><L><L><N><Y><L><R><E><N><K><G><K><L><R><K><E><M><L><L><S><V><C><Q><D><I><C><E><G><M><E><Y><L><E><R><N><G><Y><I><H><R><D><L><A><A><R><N><C><L><V><S><S><T><C><I><V><K><I><S><D><F><G><M><T><R><Y><V><L><D><D><E><Y><V><S><S><F><G><A><K><F><P><I><K><W><S><P><P><E><V><F><L><F><N><K><Y><S><S><K><S><D><V><W><S><F><G><V><L><M><W><E><V><F><T><E><G><K><M><P><F><E><N><K><S><N><L><Q><V><V><E><A><I><S><E><G><F><R><L><Y><R><P><H><L><A><P><M><S><I><Y><E><V><M><Y><S><C><W><H><E><K><P><E><G><R><P><T><F><A><E><L><L><R><A><V><T><E><I><A><E><T><W>	Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 . Within the complex, phosphorylates both PARP1 and EEF1A1	P42681
Q569K4	Z385B_HUMAN	Zinc finger protein 533	Homo	<M><N><M><A><N><F><L><R><G><F><E><E><K><G><I><K><N><D><R><P><E><D><Q><L><S><K><E><K><K><K><I><L><F><S><F><C><E><V><C><N><I><Q><L><N><S><A><A><Q><A><Q><V><H><S><N><G><K><S><H><R><K><R><V><K><Q><L><S><D><G><Q><P><P><P><P><A><Q><A><S><P><S><S><N><S><S><T><G><S><T><C><H><T><T><T><L><P><A><L><V><R><T><P><T><L><M><M><Q><P><S><L><D><I><K><P><F><M><S><F><P><V><D><S><S><S><A><V><G><L><F><P><N><F><N><T><M><D><P><V><Q><K><A><V><I><N><H><T><F><G><V><S><I><P><P><K><K><K><Q><V><I><S><C><N><V><C><Q><L><R><F><N><S><D><S><Q><A><E><A><H><Y><K><G><S><K><H><A><K><K><V><K><A><L><D><A><T><K><N><K><P><K><M><V><P><S><K><D><S><A><K><A><N><P><S><C><S><I><T><P><I><T><G><N><N><S><D><K><S><E><D><K><G><K><L><K><A><S><S><S><S><Q><P><S><S><S><E><S><G><S><F><L><L><K><S><G><T><T><P><L><P><P><G><A><A><T><S><P><S><K><S><T><N><G><A><P><G><T><V><V><E><S><E><E><E><K><A><K><K><L><L><Y><C><S><L><C><K><V><A><V><N><S><L><S><Q><L><E><A><H><N><T><G><S><K><H><K><T><M><V><E><A><R><N><G><A><G><P><I><K><S><Y><P><R><P><G><S><R><L><K><M><Q><N><G><S><K><G><S><G><L><Q><N><K><T><F><H><C><E><I><C><D><V><H><V><N><S><E><I><Q><L><K><Q><H><I><S><S><R><R><H><K><D><R><V><A><G><K><P><L><K><P><K><Y><S><P><Y><N><K><L><Q><R><S><P><S><I><L><A><A><K><L><A><F><Q><K><D><M><M><K><P><L><A><P><A><F><L><S><S><P><L><A><A><A><A><A><V><S><S><A><L><S><L><P><P><R><P><S><A><S><L><F><Q><A><P><A><I><P><P><A><L><L><R><P><G><H><G><P><I><R><A><T><P><A><S><I><L><F><A><P><Y>	May play a role in p53/TP53-mediated apoptosis.<BOP>	Q569K4
P59990	KR121_HUMAN	Keratin-associated protein 12.1	Homo	<M><C><H><T><S><C><S><S><G><C><Q><P><A><C><C><A><P><S><P><C><Q><A><S><C><Y><I><P><V><G><C><Q><S><S><V><C><V><P><V><S><F><K><P><A><V><C><V><P><V><R><C><Q><S><S><V><C><V><P><V><S><C><R><P><V><V><Y><A><A><P><S><C><Q><S><S><G><C><C><Q><P><S><C><T><S><V><L><C><R><P><I><S><C><S><T><P><S><C><C>	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>	P59990
P27169	PON1_HUMAN	Serum aryldialkylphosphatase 1	Homo	<M><A><K><L><I><A><L><T><L><L><G><M><G><L><A><L><F><R><N><H><Q><S><S><Y><Q><T><R><L><N><A><L><R><E><V><Q><P><V><E><L><P><N><C><N><L><V><K><G><I><E><T><G><S><E><D><L><E><I><L><P><N><G><L><A><F><I><S><S><G><L><K><Y><P><G><I><K><S><F><N><P><N><S><P><G><K><I><L><L><M><D><L><N><E><E><D><P><T><V><L><E><L><G><I><T><G><S><K><F><D><V><S><S><F><N><P><H><G><I><S><T><F><T><D><E><D><N><A><M><Y><L><L><V><V><N><H><P><D><A><K><S><T><V><E><L><F><K><F><Q><E><E><E><K><S><L><L><H><L><K><T><I><R><H><K><L><L><P><N><L><N><D><I><V><A><V><G><P><E><H><F><Y><G><T><N><D><H><Y><F><L><D><P><Y><L><Q><S><W><E><M><Y><L><G><L><A><W><S><Y><V><V><Y><Y><S><P><S><E><V><R><V><V><A><E><G><F><D><F><A><N><G><I><N><I><S><P><D><G><K><Y><V><Y><I><A><E><L><L><A><H><K><I><H><V><Y><E><K><H><A><N><W><T><L><T><P><L><K><S><L><D><F><N><T><L><V><D><N><I><S><V><D><P><E><T><G><D><L><W><V><G><C><H><P><N><G><M><K><I><F><F><Y><D><S><E><N><P><P><A><S><E><V><L><R><I><Q><N><I><L><T><E><E><P><K><V><T><Q><V><Y><A><E><N><G><T><V><L><Q><G><S><T><V><A><S><V><Y><K><G><K><L><L><I><G><T><V><F><H><K><A><L><Y><C><E><L>	Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.<BOP>	P27169
Q8WYQ3	CHC10_HUMAN	Protein N27C7-4	Homo	<M><P><R><G><S><R><S><A><A><S><R><P><A><S><R><P><A><A><P><S><A><H><P><P><A><H><P><P><P><S><A><A><A><P><A><P><A><P><S><G><Q><P><G><L><M><A><Q><M><A><T><T><A><A><G><V><A><V><G><S><A><V><G><H><V><M><G><S><A><L><T><G><A><F><S><G><G><S><S><E><P><S><Q><P><A><V><Q><Q><A><P><T><P><A><A><P><Q><P><L><Q><M><G><P><C><A><Y><E><I><R><Q><F><L><D><C><S><T><T><Q><S><D><L><S><L><C><E><G><F><S><E><A><L><K><Q><C><K><Y><Y><H><G><L><S><S><L><P>	May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.<BOP>	Q8WYQ3
Q9UBM1	PEMT_HUMAN	Phospholipid methyltransferase	Homo	<M><T><R><L><L><G><Y><V><D><P><L><D><P><S><F><V><A><A><V><I><T><I><T><F><N><P><L><Y><W><N><V><V><A><R><W><E><H><K><T><R><K><L><S><R><A><F><G><S><P><Y><L><A><C><Y><S><L><S><V><T><I><L><L><L><N><F><L><R><S><H><C><F><T><Q><A><M><L><S><Q><P><R><M><E><S><L><D><T><P><A><A><Y><S><L><G><L><A><L><L><G><L><G><V><V><L><V><L><S><S><F><F><A><L><G><F><A><G><T><F><L><G><D><Y><F><G><I><L><K><E><A><R><V><T><V><F><P><F><N><I><L><D><N><P><M><Y><W><G><S><T><A><N><Y><L><G><W><A><I><M><H><A><S><P><T><G><L><L><L><T><V><L><V><A><L><T><Y><I><V><A><L><L><Y><E><E><P><F><T><A><E><I><Y><R><Q><K><A><S><G><S><H><K><R><S>	Produces a higher increase in the level of PC species containing long chains with three double bonds than isoform 1.<BOP>	Q9UBM1
Q9YNA8	GAK19_HUMAN	HERV-K_19q11 provirus ancestral Gag polyprotein	Homo	<M><G><Q><T><K><S><K><I><K><S><K><Y><A><S><Y><L><S><F><I><K><I><L><L><K><R><G><G><V><K><V><S><T><K><N><L><I><K><L><F><Q><I><I><E><Q><F><C><P><W><F><P><E><Q><G><T><L><D><L><K><D><W><K><R><I><G><K><E><L><K><Q><A><G><R><K><G><N><I><I><P><L><T><V><W><N><D><W><A><I><I><K><A><A><L><E><P><F><Q><T><E><E><D><S><V><S><V><S><D><A><P><G><S><C><I><I><D><C><N><E><N><T><R><K><K><S><Q><K><E><T><E><S><L><H><C><E><Y><V><A><E><P><V><M><A><Q><S><T><Q><N><V><D><Y><N><Q><L><Q><E><V><I><Y><P><E><T><L><K><L><E><G><K><V><P><E><L><V><G><P><S><E><S><K><P><R><G><T><S><R><L><P><A><G><Q><V><P><V><T><L><Q><P><Q><T><Q><V><K><E><N><K><T><Q><P><P><V><A><Y><Q><Y><W><P><P><A><E><L><Q><Y><R><P><P><L><E><S><Q><Y><G><Y><P><G><M><P><P><A><P><Q><G><R><A><P><Y><P><Q><P><P><T><R><R><L><N><P><T><A><P><P><S><R><R><G><S><E><L><H><E><I><I><D><K><S><R><K><E><G><D><T><E><A><W><Q><F><P><V><T><L><E><P><M><P><P><G><E><G><A><Q><E><G><E><P><P><T><V><E><A><R><Y><K><S><F><S><I><K><M><L><K><D><M><K><E><G><V><K><Q><Y><G><P><N><S><P><Y><M><R><T><L><L><D><S><I><A><H><G><H><R><L><I><P><Y><D><W><E><I><L><A><K><S><S><L><S><P><S><Q><F><L><Q><F><K><T><W><W><I><D><G><V><Q><E><Q><V><R><R><N><R><A><A><N><P><P><V><N><I><D><A><D><Q><L><L><G><I><G><Q><N><W><S><T><I><S><Q><Q><A><L><M><Q><N><E><A><I><E><Q><V><R><A><I><C><L><R><A><W><E><K><I><Q><D><P><G><S><T><C><P><S><F><N><T><V><R><Q><G><S><K><E><P><Y><P><D><F><V><A><R><L><Q><D><V><A><Q><K><S><I><A><I><E><K><A><R><K><V><I><V><E><L><M><A><Y><E><N><P><N><P><E><C><Q><S><A><I><K><P><L><K><G><K><V><P><A><G><S><D><V><I><S><E><Y><V><K><A><C><D><G><M><G><G><A><M><H><K><A><M><L><M><A><Q><A><I><T><G><V><V><L><G><G><Q><V><R><T><F><G><G><K><C><Y><N><C><G><Q><I><G><H><L><K><K><N><C><P><V><L><N><K><Q><N><I><T><I><Q><A><T><T><T><G><R><E><P><P><D><L><C><P><R><C><K><K><G><K><H><W><A><S><Q><C><R><S><K><F><D><K><N><G><Q><P><L><S><G><N><E><Q><R><G><Q><P><Q><A><P><Q><Q><T><G><A><F><P><I><Q><P><F><V><P><H><G><F><Q><G><Q><Q><P><P><L><S><Q><V><F><Q><G><I><S><Q><L><P><Q><Y><N><N><C><P><P><P><Q><A><A><V><Q><Q>	The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.<BOP>	Q9YNA8
Q9BQB4	SOST_HUMAN	Sclerostin	Homo	<M><Q><L><P><L><A><L><C><L><V><C><L><L><V><H><T><A><F><R><V><V><E><G><Q><G><W><Q><A><F><K><N><D><A><T><E><I><I><P><E><L><G><E><Y><P><E><P><P><P><E><L><E><N><N><K><T><M><N><R><A><E><N><G><G><R><P><P><H><H><P><F><E><T><K><D><V><S><E><Y><S><C><R><E><L><H><F><T><R><Y><V><T><D><G><P><C><R><S><A><K><P><V><T><E><L><V><C><S><G><Q><C><G><P><A><R><L><L><P><N><A><I><G><R><G><K><W><W><R><P><S><G><P><D><F><R><C><I><P><D><R><Y><R><A><Q><R><V><Q><L><L><C><P><G><G><E><A><P><R><A><R><K><V><R><L><V><A><S><C><K><C><K><R><L><T><R><F><H><N><Q><S><E><L><K><D><F><G><T><E><A><A><R><P><Q><K><G><R><K><P><R><P><R><A><R><S><A><K><A><N><Q><A><E><L><E><N><A><Y>	Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.<BOP>	Q9BQB4
Q15560	TCEA2_HUMAN	Transcription elongation factor TFIIS.l	Homo	<M><M><G><K><E><E><E><I><A><R><I><A><R><R><L><D><K><M><V><T><K><K><S><A><E><G><A><M><D><L><L><R><E><L><K><A><M><P><I><T><L><H><L><L><Q><S><T><R><V><G><M><S><V><N><A><L><R><K><Q><S><S><D><E><E><V><I><A><L><A><K><S><L><I><K><S><W><K><K><L><L><D><A><S><D><A><K><A><R><E><R><G><R><G><M><P><L><P><T><S><S><R><D><A><S><E><A><P><D><P><S><R><K><R><P><E><L><P><R><A><P><S><T><P><R><I><T><T><F><P><P><V><P><V><T><C><D><A><V><R><N><K><C><R><E><M><L><T><A><A><L><Q><T><D><H><D><H><V><A><I><G><A><D><C><E><R><L><S><A><Q><I><E><E><C><I><F><R><D><V><G><N><T><D><M><K><Y><K><N><R><V><R><S><R><I><S><N><L><K><D><A><K><N><P><D><L><R><R><N><V><L><C><G><A><I><T><P><Q><Q><I><A><V><M><T><S><E><E><M><A><S><D><E><L><K><E><I><R><K><A><M><T><K><E><A><I><R><E><H><Q><M><A><R><T><G><G><T><Q><T><D><L><F><T><C><G><K><C><R><K><K><N><C><T><Y><T><Q><V><Q><T><R><S><S><D><E><P><M><T><T><F><V><V><C><N><E><C><G><N><R><W><K><F><C>	Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.<BOP>	Q15560
Q8NG98	OR7D4_HUMAN	Olfactory receptor OR19-7	Homo	<M><E><A><E><N><L><T><E><L><S><K><F><L><L><L><G><L><S><D><D><P><E><L><Q><P><V><L><F><G><L><F><L><S><M><Y><L><V><T><V><L><G><N><L><L><I><I><L><A><V><S><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><V><D><I><C><F><I><S><T><T><V><P><K><M><L><V><S><I><Q><A><R><S><K><D><I><S><Y><M><G><C><L><T><Q><V><Y><F><L><M><M><F><A><G><M><D><T><F><L><L><A><V><M><A><Y><D><R><F><V><A><I><C><H><P><L><H><Y><T><V><I><M><N><P><C><L><C><G><L><L><V><L><A><S><W><F><I><I><F><W><F><S><L><V><H><I><L><L><M><K><R><L><T><F><S><T><G><T><E><I><P><H><F><F><C><E><P><A><Q><V><L><K><V><A><C><S><N><T><L><L><N><N><I><V><L><Y><V><A><T><A><L><L><G><V><F><P><V><A><G><I><L><F><S><Y><S><Q><I><V><S><S><L><M><G><M><S><S><T><K><G><K><Y><K><A><F><S><T><C><G><S><H><L><C><V><V><S><L><F><Y><G><T><G><L><G><V><Y><L><S><S><A><V><T><H><S><S><Q><S><S><S><T><A><S><V><M><Y><A><M><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><K><D><V><K><G><A><L><E><R><L><L><S><R><A><D><S><C><P>	Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.<BOP>	Q8NG98
Q7Z3B4	NUP54_HUMAN	54 kDa nucleoporin	Homo	<M><A><F><N><F><G><A><P><S><G><T><S><G><T><A><A><A><T><A><A><P><A><G><G><F><G><G><F><G><T><T><S><T><T><A><G><S><A><F><S><F><S><A><P><T><N><T><G><T><T><G><L><F><G><G><T><Q><N><K><G><F><G><F><G><T><G><F><G><T><T><T><G><T><S><T><G><L><G><T><G><L><G><T><G><L><G><F><G><G><F><N><T><Q><Q><Q><Q><Q><T><T><L><G><G><L><F><S><Q><P><T><Q><A><P><T><Q><S><N><Q><L><I><N><T><A><S><A><L><S><A><P><T><L><L><G><D><E><R><D><A><I><L><A><K><W><N><Q><L><Q><A><F><W><G><T><G><K><G><Y><F><N><N><N><I><P><P><V><E><F><T><Q><E><N><P><F><C><R><F><K><A><V><G><Y><S><C><M><P><S><N><K><D><E><D><G><L><V><V><L><V><F><N><K><K><E><T><E><I><R><S><Q><Q><Q><Q><L><V><E><S><L><H><K><V><L><G><G><N><Q><T><L><T><V><N><V><E><G><T><K><T><L><P><D><D><Q><T><E><V><V><I><Y><V><V><E><R><S><P><N><G><T><S><R><R><V><P><A><T><T><L><Y><A><H><F><E><Q><A><N><I><K><T><Q><L><Q><Q><L><G><V><T><L><S><M><T><R><T><E><L><S><P><A><Q><I><K><Q><L><L><Q><N><P><P><A><G><V><D><P><I><I><W><E><Q><A><K><V><D><N><P><D><S><E><K><L><I><P><V><P><M><V><G><F><K><E><L><L><R><R><L><K><V><Q><D><Q><M><T><K><Q><H><Q><T><R><L><D><I><I><S><E><D><I><S><E><L><Q><K><N><Q><T><T><S><V><A><K><I><A><Q><Y><K><R><K><L><M><D><L><S><H><R><T><L><Q><V><L><I><K><Q><E><I><Q><R><K><S><G><Y><A><I><Q><A><D><E><E><Q><L><R><V><Q><L><D><T><I><Q><G><E><L><N><A><P><T><Q><F><K><G><R><L><N><E><L><M><S><Q><I><R><M><Q><N><H><F><G><A><V><R><S><E><E><R><Y><Y><I><D><A><D><L><L><R><E><I><K><Q><H><L><K><Q><Q><Q><E><G><L><S><H><L><I><S><I><I><K><D><D><L><E><D><I><K><L><V><E><H><G><L><N><E><T><I><H><I><R><G><G><V><F><S>	Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.<BOP>	Q7Z3B4
Q8NBA8	DTWD2_HUMAN	DTW domain-containing protein 2	Homo	<M><E><S><Q><K><E><A><R><T><L><Q><E><P><V><A><R><P><S><G><A><S><S><S><Q><T><P><N><D><K><E><R><R><E><G><G><A><V><P><A><A><A><A><L><G><A><E><A><D><D><D><S><A><D><G><L><W><E><L><P><V><E><P><A><E><R><R><P><E><C><T><R><C><S><R><P><Q><K><V><C><L><C><P><F><L><P><A><H><P><L><H><I><S><T><H><L><Y><I><I><Q><H><P><A><E><E><N><K><V><L><R><T><V><P><L><L><A><A><C><L><P><Q><D><K><C><K><V><K><I><G><R><R><F><S><E><E><R><D><P><E><L><S><T><V><C><R><K><S><G><T><L><I><L><Y><P><G><A><E><A><A><N><L><E><E><F><I><L><D><S><P><V><Y><P><S><T><I><I><I><I><D><G><T><W><S><Q><A><K><D><I><F><Y><K><N><S><L><F><R><H><P><K><Q><V><Q><L><K><T><S><I><S><S><Q><Y><V><I><R><M><Q><P><T><N><R><C><L><S><T><L><E><C><A><A><V><A><L><S><I><L><E><K><N><N><Y><I><Q><E><T><L><L><R><P><L><Q><A><L><C><S><F><Q><L><Q><H><G><A><Q><I><R><L><S><K><E><H><L><L><K><N><G><L><Y><P><K><P><M><P><K><N><K><R><K><L><R><K><M><E><L><L><M><N><S><V><K><I>	Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) . Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) .<BOP>	Q8NBA8
P05090	APOD_HUMAN	Apolipoprotein D	Homo	<M><V><M><L><L><L><L><L><S><A><L><A><G><L><F><G><A><A><E><G><Q><A><F><H><L><G><K><C><P><N><P><P><V><Q><E><N><F><D><V><N><K><Y><L><G><R><W><Y><E><I><E><K><I><P><T><T><F><E><N><G><R><C><I><Q><A><N><Y><S><L><M><E><N><G><K><I><K><V><L><N><Q><E><L><R><A><D><G><T><V><N><Q><I><E><G><E><A><T><P><V><N><L><T><E><P><A><K><L><E><V><K><F><S><W><F><M><P><S><A><P><Y><W><I><L><A><T><D><Y><E><N><Y><A><L><V><Y><S><C><T><C><I><I><Q><L><F><H><V><D><F><A><W><I><L><A><R><N><P><N><L><P><P><E><T><V><D><S><L><K><N><I><L><T><S><N><N><I><D><V><K><K><M><T><V><T><D><Q><V><N><C><P><K><L><S>	APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.<BOP>	P05090
A0A075B6N1	TVB19_HUMAN	T cell receptor beta variable 19	Homo	<M><S><N><Q><V><L><C><C><V><V><L><C><L><L><G><A><N><T><V><D><G><G><I><T><Q><S><P><K><Y><L><F><R><K><E><G><Q><N><V><T><L><S><C><E><Q><N><L><N><H><D><A><M><Y><W><Y><R><Q><D><P><G><Q><G><L><R><L><I><Y><Y><S><Q><I><V><N><D><F><Q><K><G><D><I><A><E><G><Y><S><V><S><R><E><K><K><E><S><F><P><L><T><V><T><S><A><Q><K><N><P><T><A><F><Y><L><C><A><S><S><I>	V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement	A0A075B6N1
Q8N9M5	TM102_HUMAN	Common beta-chain associated protein	Homo	<M><A><S><A><V><W><G><S><A><P><W><W><G><P><P><P><P><A><P><A><R><P><L><T><D><I><D><F><C><S><G><A><Q><L><Q><E><L><T><Q><L><I><Q><E><L><G><V><Q><E><S><W><S><D><G><P><K><P><G><A><D><L><L><R><A><K><D><F><V><F><S><L><L><G><L><V><H><R><R><D><P><R><F><P><P><Q><A><E><L><L><L><L><R><G><G><I><R><E><G><S><L><D><L><G><H><A><P><L><G><P><Y><A><R><G><P><H><Y><D><A><G><F><T><L><L><V><P><M><F><S><L><D><G><T><E><L><Q><L><D><L><E><S><C><Y><A><Q><V><C><L><P><E><M><V><C><G><T><P><I><R><E><M><W><Q><D><C><L><G><P><P><V><P><G><A><R><D><S><I><H><R><T><E><S><E><E><S><S><K><D><W><Q><S><S><V><D><Q><P><H><S><Y><V><T><E><H><E><A><P><V><S><L><E><K><S><P><S><D><V><S><A><S><E><S><P><Q><H><D><V><V><D><L><G><S><T><A><P><L><K><T><M><S><S><D><V><T><K><A><A><V><E><S><P><V><P><K><P><S><E><A><R><E><A><W><P><T><L><C><S><A><Q><V><A><A><W><F><F><A><T><L><A><A><V><A><E><S><L><I><P><V><P><G><A><P><R><L><V><H><A><A><R><H><A><G><F><T><T><V><L><L><A><T><P><E><P><P><R><R><L><L><L><F><D><L><I><P><V><V><S><V><A><G><W><P><E><G><A><R><S><H><S><W><A><G><P><L><A><S><E><S><A><S><F><Y><L><V><P><G><G><G><T><E><R><P><C><A><S><A><W><Q><L><C><F><A><R><Q><E><L><A><L><K><A><R><I><P><A><P><L><L><Q><A><H><A><A><A><Q><A><L><L><R><P><L><V><A><G><T><R><A><A><A><P><Y><L><L><R><T><L><L><Y><W><A><C><E><R><L><P><A><L><Y><L><A><R><P><E><N><A><G><A><C><C><L><G><L><L><D><E><L><G><R><V><L><E><A><G><T><L><P><H><Y><F><L><N><G><R><Q><L><R><T><G><D><D><S><A><A><L><L><G><E><L><A><R><L><R><G><D><P><A><R><A><L><R><A><A><V><E><E><A><K><V><A><R><K><G><G><G><L><A><G><V><G><G><G><A><H>	Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.<BOP>	Q8N9M5
P06753	TPM3_HUMAN	Tropomyosin-5	Homo	<M><M><E><A><I><K><K><K><M><Q><M><L><K><L><D><K><E><N><A><L><D><R><A><E><Q><A><E><A><E><Q><K><Q><A><E><E><R><S><K><Q><L><E><D><E><L><A><A><M><Q><K><K><L><K><G><T><E><D><E><L><D><K><Y><S><E><A><L><K><D><A><Q><E><K><L><E><L><A><E><K><K><A><A><D><A><E><A><E><V><A><S><L><N><R><R><I><Q><L><V><E><E><E><L><D><R><A><Q><E><R><L><A><T><A><L><Q><K><L><E><E><A><E><K><A><A><D><E><S><E><R><G><M><K><V><I><E><N><R><A><L><K><D><E><E><K><M><E><L><Q><E><I><Q><L><K><E><A><K><H><I><A><E><E><A><D><R><K><Y><E><E><V><A><R><K><L><V><I><I><E><G><D><L><E><R><T><E><E><R><A><E><L><A><E><S><K><C><S><E><L><E><E><E><L><K><N><V><T><N><N><L><K><S><L><E><A><Q><A><E><K><Y><S><Q><K><E><D><K><Y><E><E><E><I><K><I><L><T><D><K><L><K><E><A><E><T><R><A><E><F><A><E><R><S><V><A><K><L><E><K><T><I><D><D><L><E><D><E><L><Y><A><Q><K><L><K><Y><K><A><I><S><E><E><L><D><H><A><L><N><D><M><T><S><I>	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.<BOP>	P06753
Q01523	DEF5_HUMAN	HD5(63-94)	Homo	<M><R><T><I><A><I><L><A><A><I><L><L><V><A><L><Q><A><Q><A><E><S><L><Q><E><R><A><D><E><A><T><T><Q><K><Q><S><G><E><D><N><Q><D><L><A><I><S><F><A><G><N><G><L><S><A><L><R><T><S><G><S><Q><A><R><A><T><C><Y><C><R><T><G><R><C><A><T><R><E><S><L><S><G><V><C><E><I><S><G><R><L><Y><R><L><C><C><R>	(Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues.<BOP>	Q01523
Q96A46	MFRN2_HUMAN	Solute carrier family 25 member 28	Homo	<M><E><L><E><G><R><G><A><G><G><V><A><G><G><P><A><A><G><P><G><R><S><P><G><E><S><A><L><L><D><G><W><L><Q><R><G><V><G><R><G><A><G><G><G><E><A><G><A><C><R><P><P><V><R><Q><D><P><D><S><G><P><D><Y><E><A><L><P><A><G><A><T><V><T><T><H><M><V><A><G><A><V><A><G><I><L><E><H><C><V><M><Y><P><I><D><C><V><K><T><R><M><Q><S><L><Q><P><D><P><A><A><R><Y><R><N><V><L><E><A><L><W><R><I><I><R><T><E><G><L><W><R><P><M><R><G><L><N><V><T><A><T><G><A><G><P><A><H><A><L><Y><F><A><C><Y><E><K><L><K><K><T><L><S><D><V><I><H><P><G><G><N><S><H><I><A><N><G><A><A><G><C><V><A><T><L><L><H><D><A><A><M><N><P><A><E><V><V><K><Q><R><M><Q><M><Y><N><S><P><Y><H><R><V><T><D><C><V><R><A><V><W><Q><N><E><G><A><G><A><F><Y><R><S><Y><T><T><Q><L><T><M><N><V><P><F><Q><A><I><H><F><M><T><Y><E><F><L><Q><E><H><F><N><P><Q><R><R><Y><N><P><S><S><H><V><L><S><G><A><C><A><G><A><V><A><A><A><A><T><T><P><L><D><V><C><K><T><L><L><N><T><Q><E><S><L><A><L><N><S><H><I><T><G><H><I><T><G><M><A><S><A><F><R><T><V><Y><Q><V><G><G><V><T><A><Y><F><R><G><V><Q><A><R><V><I><Y><Q><I><P><S><T><A><I><A><W><S><V><Y><E><F><F><K><Y><L><I><T><K><R><Q><E><E><W><R><A><G><K>	Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells.<BOP>	Q96A46
Q496F6	CLM2_HUMAN	Polymeric immunoglobulin receptor 2	Homo	<M><W><L><L><P><A><L><L><L><L><C><L><S><G><C><L><S><L><K><G><P><G><S><V><T><G><T><A><G><D><S><L><T><V><W><C><Q><Y><E><S><M><Y><K><G><Y><N><K><Y><W><C><R><G><Q><Y><D><T><S><C><E><S><I><V><E><T><K><G><E><E><K><V><E><R><N><G><R><V><S><I><R><D><H><P><E><A><L><A><F><T><V><T><M><Q><N><L><N><E><D><D><A><G><S><Y><W><C><K><I><Q><T><V><W><V><L><D><S><W><S><R><D><P><S><D><L><V><R><V><Y><V><S><P><A><I><T><T><P><R><R><T><T><H><P><A><T><P><P><I><F><L><V><V><N><P><G><R><N><L><S><T><G><E><V><L><T><Q><N><S><G><F><R><L><S><S><P><H><F><L><L><V><V><L><L><K><L><P><L><L><L><S><M><L><G><A><V><F><W><V><N><R><P><Q><W><A><P><P><G><R>	Probably acts as an activating receptor.<BOP>	Q496F6
Q3LI54	KR198_HUMAN	Keratin-associated protein 19-8	Homo	<M><S><Y><Y><R><S><Y><Y><G><G><L><G><Y><G><Y><G><G><F><G><G><W><G><Y><G><Y><G><C><G><Y><G><S><F><R><R><L><G><Y><G><C><G><Y><G><G><Y><G><F><S><C><C><R><P><L><Y><Y><G><G><Y><G><F><S><A><F><Y>	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>	Q3LI54
Q16538	GP162_HUMAN	Gene-rich cluster gene A protein	Homo	<M><A><R><G><G><A><G><A><E><E><A><S><L><R><S><N><A><L><S><W><L><A><C><G><L><L><A><L><L><A><N><A><W><I><I><L><S><I><S><A><K><Q><Q><K><H><K><P><L><E><L><L><L><C><F><L><A><G><T><H><I><L><M><A><A><V><P><L><T><T><F><A><V><V><Q><L><R><R><Q><A><S><S><D><Y><D><W><N><E><S><I><C><K><V><F><V><S><T><Y><Y><T><L><A><L><A><T><C><F><T><V><A><S><L><S><Y><H><R><M><W><M><V><R><W><P><V><N><Y><R><L><S><N><A><K><K><Q><A><L><H><A><V><M><G><I><W><M><V><S><F><I><L><S><T><L><P><S><I><G><W><H><N><N><G><E><R><Y><Y><A><R><G><C><Q><F><I><V><S><K><I><G><L><G><F><G><V><C><F><S><L><L><L><L><G><G><I><V><M><G><L><V><C><V><A><I><T><F><Y><Q><T><L><W><A><R><P><R><R><A><R><Q><A><R><R><V><G><G><G><G><G><T><K><A><G><G><P><G><A><L><G><T><R><P><A><F><E><V><P><A><I><V><V><E><D><A><R><G><K><R><R><S><S><L><D><G><S><E><S><A><K><T><S><L><Q><V><T><N><L><V><S><A><I><V><F><L><Y><D><S><L><T><G><V><P><I><L><V><V><S><F><F><S><L><K><S><D><S><A><P><P><W><M><V><L><A><V><L><W><C><S><M><A><Q><T><L><L><L><P><S><F><I><W><S><C><E><R><Y><R><A><D><V><R><T><V><W><E><Q><C><V><A><I><M><S><E><E><D><G><D><D><D><G><G><C><D><D><Y><A><E><G><R><V><C><K><V><R><F><D><A><N><G><A><T><G><P><G><S><R><D><P><A><Q><V><K><L><L><P><G><R><H><M><L><F><P><P><L><E><R><V><H><Y><L><Q><V><P><L><S><R><R><L><S><H><D><E><T><N><I><F><S><T><P><R><E><P><G><S><F><L><H><K><W><S><S><S><D><D><I><R><V><L><P><A><Q><S><R><A><L><G><G><P><P><E><Y><L><G><Q><R><H><R><L><E><D><E><E><D><E><E><E><A><E><G><G><G><L><A><S><L><R><Q><F><L><E><S><G><V><L><G><S><G><G><G><P><P><R><G><P><G><F><F><R><E><E><I><T><T><F><I><D><E><T><P><L><P><S><P><T><A><S><P><G><H><S><P><R><R><P><R><P><L><G><L><S><P><R><R><L><S><L><G><S><P><E><S><R><A><V><G><L><P><L><G><L><S><A><G><R><R><C><S><L><T><G><G><E><E><S><A><R><A><W><G><G><S><W><G><P><G><N><P><I><F><P><Q><L><T><L>	Orphan receptor.<BOP>	Q16538
O75690	KRA58_HUMAN	Ultrahigh sulfur keratin-associated protein 5.8	Homo	<M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><G><R><G><S><C><G><G><S><K><G><D><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><C><S><Q><C><S><C><Y><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><S><S><C><C><K><P><C><S><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><S><S><C><C><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><S><S><C><C><V><P><I><C><C><Q><C><K><I>	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>	O75690
Q07687	DLX2_HUMAN	Homeobox protein DLX-2	Homo	<M><T><G><V><F><D><S><L><V><A><D><M><H><S><T><Q><I><A><A><S><S><T><Y><H><Q><H><Q><Q><P><P><S><G><G><G><A><G><P><G><G><N><S><S><S><S><S><S><L><H><K><P><Q><E><S><P><T><L><P><V><S><T><A><T><D><S><S><Y><Y><T><N><Q><Q><H><P><A><G><G><G><G><G><G><G><S><P><Y><A><H><M><G><S><Y><Q><Y><Q><A><S><G><L><N><N><V><P><Y><S><A><K><S><S><Y><D><L><G><Y><T><A><A><Y><T><S><Y><A><P><Y><G><T><S><S><S><P><A><N><N><E><P><E><K><E><D><L><E><P><E><I><R><I><V><N><G><K><P><K><K><V><R><K><P><R><T><I><Y><S><S><F><Q><L><A><A><L><Q><R><R><F><Q><K><T><Q><Y><L><A><L><P><E><R><A><E><L><A><A><S><L><G><L><T><Q><T><Q><V><K><I><W><F><Q><N><R><R><S><K><F><K><K><M><W><K><S><G><E><I><P><S><E><Q><H><P><G><A><S><A><S><P><P><C><A><S><P><P><V><S><A><P><A><S><W><D><F><G><V><P><Q><R><M><A><G><G><G><G><P><G><S><G><G><S><G><A><G><S><S><G><S><S><P><S><S><A><A><S><A><F><L><G><N><Y><P><W><Y><H><Q><T><S><G><S><A><S><H><L><Q><A><T><A><P><L><L><H><P><T><Q><T><P><Q><P><H><H><H><H><H><H><H><G><G><G><G><A><P><V><S><A><G><T><I><F>	Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.<BOP>	Q07687
Q13438	OS9_HUMAN	Amplified in osteosarcoma 9	Homo	<M><A><A><E><T><L><L><S><S><L><L><G><L><L><L><L><G><L><L><L><P><A><S><L><T><G><G><V><G><S><L><N><L><E><E><L><S><E><M><R><Y><G><I><E><I><L><P><L><P><V><M><G><G><Q><S><Q><S><S><D><V><V><I><V><S><S><K><Y><K><Q><R><Y><E><C><R><L><P><A><G><A><I><H><F><Q><R><E><R><E><E><E><T><P><A><Y><Q><G><P><G><I><P><E><L><L><S><P><M><R><D><A><P><C><L><L><K><T><K><D><W><W><T><Y><E><F><C><Y><G><R><H><I><Q><Q><Y><H><M><E><D><S><E><I><K><G><E><V><L><Y><L><G><Y><Y><Q><S><A><F><D><W><D><D><E><T><A><K><A><S><K><Q><H><R><L><K><R><Y><H><S><Q><T><Y><G><N><G><S><K><C><D><L><N><G><R><P><R><E><A><E><V><R><F><L><C><D><E><G><A><G><I><S><G><D><Y><I><D><R><V><D><E><P><L><S><C><S><Y><V><L><T><I><R><T><P><R><L><C><P><H><P><L><L><R><P><P><P><S><A><A><P><Q><A><I><L><C><H><P><S><L><Q><P><E><E><Y><M><A><Y><V><Q><R><Q><A><D><S><K><Q><Y><G><D><K><I><I><E><E><L><Q><D><L><G><P><Q><V><W><S><E><T><K><S><G><V><A><P><Q><K><M><A><G><A><S><P><T><K><D><D><S><K><D><S><D><F><W><K><M><L><N><E><P><E><D><Q><A><P><G><G><E><E><V><P><A><E><E><Q><D><P><S><P><E><A><A><D><S><A><S><G><A><P><N><D><F><Q><N><N><V><Q><V><K><V><I><R><S><P><A><D><L><I><R><F><I><E><E><L><K><G><G><T><K><K><G><K><P><N><I><G><Q><E><Q><P><V><D><D><A><A><E><V><P><Q><R><E><P><E><K><E><R><G><D><P><E><R><Q><R><E><M><E><E><E><E><D><E><D><E><D><E><D><E><D><E><D><E><R><Q><L><L><G><E><F><E><K><E><L><E><G><I><L><L><P><S><D><R><D><R><L><R><S><E><V><K><A><G><M><E><R><E><L><E><N><I><I><Q><E><T><E><K><E><L><D><P><D><G><L><K><K><E><S><E><R><D><R><A><M><L><A><L><T><S><T><L><N><K><L><I><K><R><L><E><E><K><Q><S><P><E><L><V><K><K><H><K><K><K><R><V><V><P><K><K><P><P><P><S><P><Q><P><T><E><E><D><P><E><H><R><V><R><V><R><V><T><K><L><R><L><G><G><P><N><Q><D><L><T><V><L><E><M><K><R><E><N><P><Q><L><K><Q><I><E><G><L><V><K><E><L><L><E><R><E><G><L><T><A><A><G><K><I><E><I><K><I><V><R><P><W><A><E><G><T><E><E><G><A><R><W><L><T><D><E><D><T><R><N><L><K><E><I><F><F><N><I><L><V><P><G><A><E><E><A><Q><K><E><R><Q><R><Q><K><E><L><E><S><N><Y><R><R><V><W><G><S><P><G><G><E><G><T><G><D><L><D><E><F><D><F>	Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.<BOP>	Q13438
Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly [ADP-ribose] polymerase	Homo	<M><E><M><E><T><T><E><P><E><P><D><C><V><V><Q><P><P><S><P><P><D><D><F><S><C><Q><M><R><L><S><E><K><I><T><P><L><K><T><C><F><K><K><K><D><Q><K><R><L><G><T><G><T><L><R><S><L><R><P><I><L><N><T><L><L><E><S><G><S><L><D><G><V><F><R><S><R><N><Q><S><T><D><E><N><S><L><H><E><P><M><M><K><K><A><M><E><I><N><S><S><C><P><P><A><E><N><N><M><S><V><L><I><P><D><R><T><N><V><G><D><Q><I><P><E><A><H><P><S><T><E><A><P><E><R><V><V><P><I><Q><D><H><S><F><P><S><E><T><L><S><G><T><V><A><D><S><T><P><A><H><F><Q><T><D><L><L><H><P><V><S><S><D><V><P><T><S><P><D><C><L><D><K><V><I><D><Y><V><P><G><I><F><Q><E><N><S><F><T><I><Q><Y><I><L><D><T><S><D><K><L><S><T><E><L><F><Q><D><K><S><E><E><A><S><L><D><L><V><F><E><L><V><N><Q><L><Q><Y><H><T><H><Q><E><N><G><I><E><I><C><M><D><F><L><Q><G><T><C><I><Y><G><R><D><C><L><K><H><H><T><V><L><P><Y><H><W><Q><I><K><R><T><T><T><Q><K><W><Q><S><V><F><N><D><S><Q><E><H><L><E><R><F><Y><C><N><P><E><N><D><R><M><R><M><K><Y><G><G><Q><E><F><W><A><D><L><N><A><M><N><V><Y><E><T><T><E><F><D><Q><L><R><R><L><S><T><P><P><S><S><N><V><N><S><I><Y><H><T><V><W><K><F><F><C><R><D><H><F><G><W><R><E><Y><P><E><S><V><I><R><L><I><E><E><A><N><S><R><G><L><K><E><V><R><F><M><M><W><N><N><H><Y><I><L><H><N><S><F><F><R><R><E><I><K><R><R><P><L><F><R><S><C><F><I><L><L><P><Y><L><Q><T><L><G><G><V><P><T><Q><A><P><P><P><L><E><A><T><S><S><S><Q><I><I><C><P><D><G><V><T><S><A><N><F><Y><P><E><T><W><V><Y><M><H><P><S><Q><D><F><I><Q><V><P><V><S><A><E><D><K><S><Y><R><I><I><Y><N><L><F><H><K><T><V><P><E><F><K><Y><R><I><L><Q><I><L><R><V><Q><N><Q><F><L><W><E><K><Y><K><R><K><K><E><Y><M><N><R><K><M><F><G><R><D><R><I><I><N><E><R><H><L><F><H><G><T><S><Q><D><V><V><D><G><I><C><K><H><N><F><D><P><R><V><C><G><K><H><A><T><M><F><G><Q><G><S><Y><F><A><K><K><A><S><Y><S><H><N><F><S><K><K><S><S><K><G><V><H><F><M><F><L><A><K><V><L><T><G><R><Y><T><M><G><S><H><G><M><R><R><P><P><P><V><N><P><G><S><V><T><S><D><L><Y><D><S><C><V><D><N><F><F><E><P><Q><I><F><V><I><F><N><D><D><Q><S><Y><P><Y><F><V><I><Q><Y><E><E><V><S><N><T><V><S><I>	ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins . Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR .<BOP>	Q7Z3E1
Q9BYV7	BCDO2_HUMAN	Beta-carotene dioxygenase 2	Homo	<M><F><F><R><V><F><L><H><F><I><R><S><H><S><A><T><A><V><D><F><L><P><V><M><V><H><R><L><P><V><F><K><R><Y><M><G><N><T><P><Q><K><K><A><V><F><G><Q><C><R><G><L><P><C><V><A><P><L><L><T><T><V><E><E><A><P><R><G><I><S><A><R><V><W><G><H><F><P><K><W><L><N><G><S><L><L><R><I><G><P><G><K><F><E><F><G><K><D><K><Y><N><H><W><F><D><G><M><A><L><L><H><Q><F><R><M><A><K><G><T><V><T><Y><R><S><K><F><L><Q><S><D><T><Y><K><A><N><S><A><K><N><R><I><V><I><S><E><F><G><T><L><A><L><P><D><P><C><K><N><V><F><E><R><F><M><S><R><F><E><L><P><G><K><A><A><A><M><T><D><N><T><N><V><N><Y><V><R><Y><K><G><D><Y><Y><L><C><T><E><T><N><F><M><N><K><V><D><I><E><T><L><E><K><T><E><K><V><D><W><S><K><F><I><A><V><N><G><A><T><A><H><P><H><Y><D><L><D><G><T><A><Y><N><M><G><N><S><F><G><P><Y><G><F><S><Y><K><V><I><R><V><P><P><E><K><V><D><L><G><E><T><I><H><G><V><Q><V><I><C><S><I><A><S><T><E><K><G><K><P><S><Y><Y><H><S><F><G><M><T><R><N><Y><I><I><F><I><E><Q><P><L><K><M><N><L><W><K><I><A><T><S><K><I><R><G><K><A><F><S><D><G><I><S><W><E><P><Q><C><N><T><R><F><H><V><V><E><K><R><T><G><Q><L><L><P><G><R><Y><Y><S><K><P><F><V><T><F><H><Q><I><N><A><F><E><D><Q><G><C><V><I><I><D><L><C><C><Q><D><N><G><R><T><L><E><V><Y><Q><L><Q><N><L><R><K><A><G><E><G><L><D><Q><V><H><N><S><A><A><K><S><F><P><R><R><F><V><L><P><L><N><V><S><L><N><A><P><E><G><D><N><L><S><P><L><S><Y><T><S><A><S><A><V><K><Q><A><D><G><T><I><W><C><S><H><E><N><L><H><Q><E><D><L><E><K><E><G><G><I><E><F><P><Q><I><Y><Y><D><R><F><S><G><K><K><Y><H><F><F><Y><G><C><G><F><R><H><L><V><G><D><S><L><I><K><V><D><V><V><N><K><T><L><K><V><W><R><E><D><G><F><Y><P><S><E><P><V><F><V><P><A><P><G><T><N><E><E><D><G><G><V><I><L><S><V><V><I><T><P><N><Q><N><E><S><N><F><I><L><V><L><D><A><K><N><F><E><E><L><G><R><A><E><V><P><V><Q><M><P><Y><G><F><H><G><T><F><I><P><I>	Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules.<BOP>	Q9BYV7
Q92997	DVL3_HUMAN	DSH homolog 3	Homo	<M><G><E><T><K><I><I><Y><H><L><D><G><Q><E><T><P><Y><L><V><K><L><P><L><P><A><E><R><V><T><L><A><D><F><K><G><V><L><Q><R><P><S><Y><K><F><F><F><K><S><M><D><D><D><F><G><V><V><K><E><E><I><S><D><D><N><A><K><L><P><C><F><N><G><R><V><V><S><W><L><V><S><A><E><G><S><H><P><D><P><A><P><F><C><A><D><N><P><S><E><L><P><P><P><M><E><R><T><G><G><I><G><D><S><R><P><P><S><F><H><P><H><A><G><G><G><S><Q><E><N><L><D><N><D><T><E><T><D><S><L><V><S><A><Q><R><E><R><P><R><R><R><D><G><P><E><H><A><T><R><L><N><G><T><A><K><G><E><R><R><R><E><P><G><G><Y><D><S><S><S><T><L><M><S><S><E><L><E><T><T><S><F><F><D><S><D><E><D><D><S><T><S><R><F><S><S><S><T><E><Q><S><S><A><S><R><L><M><R><R><H><K><R><R><R><R><K><Q><K><V><S><R><I><E><R><S><S><S><F><S><S><I><T><D><S><T><M><S><L><N><I><I><T><V><T><L><N><M><E><K><Y><N><F><L><G><I><S><I><V><G><Q><S><N><E><R><G><D><G><G><I><Y><I><G><S><I><M><K><G><G><A><V><A><A><D><G><R><I><E><P><G><D><M><L><L><Q><V><N><E><I><N><F><E><N><M><S><N><D><D><A><V><R><V><L><R><E><I><V><H><K><P><G><P><I><T><L><T><V><A><K><C><W><D><P><S><P><R><G><C><F><T><L><P><R><S><E><P><I><R><P><I><D><P><A><A><W><V><S><H><T><A><A><M><T><G><T><F><P><A><Y><G><M><S><P><S><L><S><T><I><T><S><T><S><S><S><I><T><S><S><I><P><D><T><E><R><L><D><D><F><H><L><S><I><H><S><D><M><A><A><I><V><K><A><M><A><S><P><E><S><G><L><E><V><R><D><R><M><W><L><K><I><T><I><P><N><A><F><I><G><S><D><V><V><D><W><L><Y><H><N><V><E><G><F><T><D><R><R><E><A><R><K><Y><A><S><N><L><L><K><A><G><F><I><R><H><T><V><N><K><I><T><F><S><E><Q><C><Y><Y><I><F><G><D><L><C><G><N><M><A><N><L><S><L><H><D><H><D><G><S><S><G><A><S><D><Q><D><T><L><A><P><L><P><H><P><G><A><A><P><W><P><M><A><F><P><Y><Q><Y><P><P><P><P><H><P><Y><N><P><H><P><G><F><P><E><L><G><Y><S><Y><G><G><G><S><A><S><S><Q><H><S><E><G><S><R><S><S><G><S><N><R><S><G><S><D><R><R><K><E><K><D><P><K><A><G><D><S><K><S><G><G><S><G><S><E><S><D><H><T><T><R><S><S><L><R><G><P><R><E><R><A><P><S><E><R><S><G><P><A><A><S><E><H><S><H><R><S><H><H><S><L><A><S><S><L><R><S><H><H><T><H><P><S><Y><G><P><P><G><V><P><P><L><Y><G><P><P><M><L><M><M><P><P><P><P><A><A><M><G><P><P><G><A><P><P><G><R><D><L><A><S><V><P><P><E><L><T><A><S><R><Q><S><F><R><M><A><M><G><N><P><S><E><F><F><V><D><V><M>	Involved in the signal transduction pathway mediated by multiple Wnt genes.<BOP>	Q92997
Q15836	VAMP3_HUMAN	Synaptobrevin-3	Homo	<M><S><T><G><P><T><A><A><T><G><S><N><R><R><L><Q><Q><T><Q><N><Q><V><D><E><V><V><D><I><M><R><V><N><V><D><K><V><L><E><R><D><Q><K><L><S><E><L><D><D><R><A><D><A><L><Q><A><G><A><S><Q><F><E><T><S><A><A><K><L><K><R><K><Y><W><W><K><N><C><K><M><W><A><I><G><I><T><V><L><V><I><F><I><I><I><I><I><V><W><V><V><S><S>	SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.<BOP>	Q15836
Q12874	SF3A3_HUMAN	Spliceosome-associated protein 61	Homo	<M><E><T><I><L><E><Q><Q><R><R><Y><H><E><E><K><E><R><L><M><D><V><M><A><K><E><M><L><T><K><K><S><T><L><R><D><Q><I><N><S><D><H><R><T><R><A><M><Q><D><R><Y><M><E><V><S><G><N><L><R><D><L><Y><D><D><K><D><G><L><R><K><E><E><L><N><A><I><S><G><P><N><E><F><A><E><F><Y><N><R><L><K><Q><I><K><E><F><H><R><K><H><P><N><E><I><C><V><P><M><S><V><E><F><E><E><L><L><K><A><R><E><N><P><S><E><E><A><Q><N><L><V><E><F><T><D><E><E><G><Y><G><R><Y><L><D><L><H><D><C><Y><L><K><Y><I><N><L><K><A><S><E><K><L><D><Y><I><T><Y><L><S><I><F><D><Q><L><F><D><I><P><K><E><R><K><N><A><E><Y><K><R><Y><L><E><M><L><L><E><Y><L><Q><D><Y><T><D><R><V><K><P><L><Q><D><Q><N><E><L><F><G><K><I><Q><A><E><F><E><K><K><W><E><N><G><T><F><P><G><W><P><K><E><T><S><S><A><L><T><H><A><G><A><H><L><D><L><S><A><F><S><S><W><E><E><L><A><S><L><G><L><D><R><L><K><S><A><L><L><A><L><G><L><K><C><G><G><T><L><E><E><R><A><Q><R><L><F><S><T><K><G><K><S><L><E><S><L><D><T><S><L><F><A><K><N><P><K><S><K><G><T><K><R><D><T><E><R><N><K><D><I><A><F><L><E><A><Q><I><Y><E><Y><V><E><I><L><G><E><Q><R><H><L><T><H><E><N><V><Q><R><K><Q><A><R><T><G><E><E><R><E><E><E><E><E><E><Q><I><S><E><S><E><S><E><D><E><E><N><E><I><I><Y><N><P><K><N><L><P><L><G><W><D><G><K><P><I><P><Y><W><L><Y><K><L><H><G><L><N><I><N><Y><N><C><E><I><C><G><N><Y><T><Y><R><G><P><K><A><F><Q><R><H><F><A><E><W><R><H><A><H><G><M><R><C><L><G><I><P><N><T><A><H><F><A><N><V><T><Q><I><E><D><A><V><S><L><W><A><K><L><K><L><Q><K><A><S><E><R><W><Q><P><D><T><E><E><E><Y><E><D><S><S><G><N><V><V><N><K><K><T><Y><E><D><L><K><R><Q><G><L><L>	Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex . Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes .<BOP>	Q12874
Q9Y4L5	RN115_HUMAN	Zinc finger protein 364	Homo	<M><A><E><A><S><A><A><G><A><D><S><G><A><A><V><A><A><H><R><F><F><C><H><F><C><K><G><E><V><S><P><K><L><P><E><Y><I><C><P><R><C><E><S><G><F><I><E><E><V><T><D><D><S><S><F><L><G><G><G><G><S><R><I><D><N><T><T><T><T><H><F><A><E><L><W><G><H><L><D><H><T><M><F><F><Q><D><F><R><P><F><L><S><S><S><P><L><D><Q><D><N><R><A><N><E><R><G><H><Q><T><H><T><D><F><W><G><A><R><P><P><R><L><P><L><G><R><R><Y><R><S><R><G><S><S><R><P><D><R><S><P><A><I><E><G><I><L><Q><H><I><F><A><G><F><F><A><N><S><A><I><P><G><S><P><H><P><F><S><W><S><G><M><L><H><S><N><P><G><D><Y><A><W><G><Q><T><G><L><D><A><I><V><T><Q><L><L><G><Q><L><E><N><T><G><P><P><P><A><D><K><E><K><I><T><S><L><P><T><V><T><V><T><Q><E><Q><V><D><M><G><L><E><C><P><V><C><K><E><D><Y><T><V><E><E><E><V><R><Q><L><P><C><N><H><F><F><H><S><S><C><I><V><P><W><L><E><L><H><D><T><C><P><V><C><R><K><S><L><N><G><E><D><S><T><R><Q><S><Q><S><T><E><A><S><A><S><N><R><F><S><N><D><S><Q><L><H><D><R><W><T><F>	E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.<BOP>	Q9Y4L5
O75368	SH3L1_HUMAN	SH3 domain-binding glutamic acid-rich-like protein 1	Homo	<M><V><I><R><V><Y><I><A><S><S><S><G><S><T><A><I><K><K><K><Q><Q><D><V><L><G><F><L><E><A><N><K><I><G><F><E><E><K><D><I><A><A><N><E><E><N><R><K><W><M><R><E><N><V><P><E><N><S><R><P><A><T><G><Y><P><L><P><P><Q><I><F><N><E><S><Q><Y><R><G><D><Y><D><A><F><F><E><A><R><E><N><N><A><V><Y><A><F><L><G><L><T><A><P><P><G><S><K><E><A><E><V><Q><A><K><Q><Q><A>	Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs . May function as a ubiquitin ligase-substrate adapter . Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs .<BOP>	O75368
Q9H4B8	DPEP3_HUMAN	Dipeptidase 3	Homo	<M><Q><P><T><G><R><E><G><S><R><A><L><S><R><R><Y><L><R><R><L><L><L><L><L><L><L><L><L><L><R><Q><P><V><T><R><A><E><T><T><P><G><A><P><R><A><L><S><T><L><G><S><P><S><L><F><T><T><P><G><V><P><S><A><L><T><T><P><G><L><T><T><P><G><T><P><K><T><L><D><L><R><G><R><A><Q><A><L><M><R><S><F><P><L><V><D><G><H><N><D><L><P><Q><V><L><R><Q><R><Y><K><N><V><L><Q><D><V><N><L><R><N><F><S><H><G><Q><T><S><L><D><R><L><R><D><G><L><V><G><A><Q><F><W><S><A><S><V><S><C><Q><S><Q><D><Q><T><A><V><R><L><A><L><E><Q><I><D><L><I><H><R><M><C><A><S><Y><S><E><L><E><L><V><T><S><A><E><G><L><N><S><S><Q><K><L><A><C><L><I><G><V><E><G><G><H><S><L><D><S><S><L><S><V><L><R><S><F><Y><V><L><G><V><R><Y><L><T><L><T><F><T><C><S><T><P><W><A><E><S><S><T><K><F><R><H><H><M><Y><T><N><V><S><G><L><T><S><F><G><E><K><V><V><E><E><L><N><R><L><G><M><M><I><D><L><S><Y><A><S><D><T><L><I><R><R><V><L><E><V><S><Q><A><P><V><I><F><S><H><S><A><A><R><A><V><C><D><N><L><L><N><V><P><D><D><I><L><Q><L><L><K><K><N><G><G><I><V><M><V><T><L><S><M><G><V><L><Q><C><N><L><L><A><N><V><S><T><V><A><D><H><F><D><H><I><R><A><V><I><G><S><E><F><I><G><I><G><G><N><Y><D><G><T><G><R><F><P><Q><G><L><E><D><V><S><T><Y><P><V><L><I><E><E><L><L><S><R><S><W><S><E><E><E><L><Q><G><V><L><R><G><N><L><L><R><V><F><R><Q><V><E><K><V><R><E><E><S><R><A><Q><S><P><V><E><A><E><F><P><Y><G><Q><L><S><T><S><C><H><S><H><L><V><P><Q><N><G><H><Q><A><T><H><L><E><V><T><K><Q><P><T><N><R><V><P><W><R><S><S><N><A><S><P><Y><L><V><P><G><L><V><A><A><A><T><I><P><T><F><T><Q><W><L><C>	Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem . The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide . A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance .<BOP>	Q9H4B8
C9JVI0	U17LB_HUMAN	Ubiquitin carboxyl-terminal hydrolase 17-like protein 11	Homo	<M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><T><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><T><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>	C9JVI0
Q02080	MEF2B_HUMAN	Serum response factor-like protein 2	Homo	<M><G><R><K><K><I><Q><I><S><R><I><L><D><Q><R><N><R><Q><V><T><F><T><K><R><K><F><G><L><M><K><K><A><Y><E><L><S><V><L><C><D><C><E><I><A><L><I><I><F><N><S><A><N><R><L><F><Q><Y><A><S><T><D><M><D><R><V><L><L><K><Y><T><E><Y><S><E><P><H><E><S><R><T><N><T><D><I><L><E><T><L><K><R><R><G><I><G><L><D><G><P><E><L><E><P><D><E><G><P><E><E><P><G><E><K><F><R><R><L><A><G><E><G><G><D><P><A><L><P><R><P><R><L><Y><P><A><A><P><A><M><P><S><P><D><V><V><Y><G><A><L><P><P><P><G><C><D><P><S><G><L><G><E><A><L><P><A><Q><S><R><P><S><P><F><R><P><A><A><P><K><A><G><P><P><G><L><V><H><P><L><F><S><P><S><H><L><T><S><K><T><P><P><P><L><Y><L><P><T><E><G><R><R><S><D><L><P><G><G><L><A><G><P><R><G><G><L><N><T><S><R><S><L><Y><S><G><L><Q><N><P><C><S><T><A><T><P><G><P><P><L><G><S><F><P><F><L><P><G><G><P><P><V><G><A><E><A><W><A><R><R><V><P><Q><P><A><A><P><P><R><R><P><P><Q><S><A><S><S><L><S><A><S><L><R><P><P><G><A><P><A><T><F><L><R><P><S><P><I><P><C><S><S><P><G><P><W><Q><S><L><C><G><L><G><P><P><C><A><G><C><P><W><P><T><A><G><P><G><R><R><S><P><G><G><T><S><P><E><R><S><P><G><T><A><R><A><R><G><D><P><T><S><L><Q><A><S><S><E><K><T><Q><Q>	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.<BOP>	Q02080
Q8WXW3	PIBF1_HUMAN	Centrosomal protein of 90 kDa	Homo	<M><S><R><K><I><S><K><E><S><K><K><V><N><I><S><S><S><L><E><S><E><D><I><S><L><E><T><T><V><P><T><D><D><I><S><S><S><E><E><R><E><G><K><V><R><I><T><R><Q><L><I><E><R><K><E><L><L><H><N><I><Q><L><L><K><I><E><L><S><Q><K><T><M><M><I><D><N><L><K><V><D><Y><L><T><K><I><E><E><L><E><E><K><L><N><D><A><L><H><Q><K><Q><L><L><T><L><R><L><D><N><Q><L><A><F><Q><Q><K><D><A><S><K><Y><Q><E><L><M><K><Q><E><M><E><T><I><L><L><R><Q><K><Q><L><E><E><T><N><L><Q><L><R><E><K><A><G><D><V><R><R><N><L><R><D><F><E><L><T><E><E><Q><Y><I><K><L><K><A><F><P><E><D><Q><L><S><I><P><E><Y><V><S><V><R><F><Y><E><L><V><N><P><L><R><K><E><I><C><E><L><Q><V><K><K><N><I><L><A><E><E><L><S><T><N><K><N><Q><L><K><Q><L><T><E><T><Y><E><E><D><R><K><N><Y><S><E><V><Q><I><R><C><Q><R><L><A><L><E><L><A><D><T><K><Q><L><I><Q><Q><G><D><Y><R><Q><E><N><Y><D><K><V><K><S><E><R><D><A><L><E><Q><E><V><I><E><L><R><R><K><H><E><I><L><E><A><S><H><M><I><Q><T><K><E><R><S><E><L><S><K><E><V><V><T><L><E><Q><T><V><T><L><L><Q><K><D><K><E><Y><L><N><R><Q><N><M><E><L><S><V><R><C><A><H><E><E><D><R><L><E><R><L><Q><A><Q><L><E><E><S><K><K><A><R><E><E><M><Y><E><K><Y><V><A><S><R><D><H><Y><K><T><E><Y><E><N><K><L><H><D><E><L><E><Q><I><R><L><K><T><N><Q><E><I><D><Q><L><R><N><A><S><R><E><M><Y><E><R><E><N><R><N><L><R><E><A><R><D><N><A><V><A><E><K><E><R><A><V><M><A><E><K><D><A><L><E><K><H><D><Q><L><L><D><R><Y><R><E><L><Q><L><S><T><E><S><K><V><T><E><F><L><H><Q><S><K><L><K><S><F><E><S><E><R><V><Q><L><L><Q><E><E><T><A><R><N><L><T><Q><C><Q><L><E><C><E><K><Y><Q><K><K><L><E><V><L><T><K><E><F><Y><S><L><Q><A><S><S><E><K><R><I><T><E><L><Q><A><Q><N><S><E><H><Q><A><R><L><D><I><Y><E><K><L><E><K><E><L><D><E><I><I><M><Q><T><A><E><I><E><N><E><D><E><A><E><R><V><L><F><S><Y><G><Y><G><A><N><V><P><T><T><A><K><R><R><L><K><Q><S><V><H><L><A><R><R><V><L><Q><L><E><K><Q><N><S><L><I><L><K><D><L><E><H><R><K><D><Q><V><T><Q><L><S><Q><E><L><D><R><A><N><S><L><L><N><Q><T><Q><Q><P><Y><R><Y><L><I><E><S><V><R><Q><R><D><S><K><I><D><S><L><T><E><S><I><A><Q><L><E><K><D><V><S><N><L><N><K><E><K><S><A><L><L><Q><T><K><N><Q><M><A><L><D><L><E><Q><L><L><N><H><R><E><E><L><A><A><M><K><Q><I><L><V><K><M><H><S><K><H><S><E><N><S><L><L><L><T><K><T><E><P><K><H><V><T><E><N><Q><K><S><K><T><L><N><V><P><K><E><H><E><D><N><I><F><T><P><K><P><T><L><F><T><K><K><E><A><P><E><W><S><K><K><Q><K><M><K><T>	The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect . Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein .<BOP>	Q8WXW3
Q9GZZ7	GFRA4_HUMAN	Persephin receptor	Homo	<M><V><R><C><L><G><P><A><L><L><L><L><L><L><L><G><S><A><S><S><V><G><G><N><R><C><V><D><A><A><E><A><C><T><A><D><A><R><C><Q><R><L><R><S><E><Y><V><A><Q><C><L><G><R><A><A><Q><G><G><C><P><R><A><R><C><R><R><A><L><R><R><F><F><A><R><G><P><P><A><L><T><H><A><L><L><F><C><P><C><A><G><P><A><C><A><E><R><R><R><Q><T><F><V><P><S><C><A><F><S><G><P><G><P><A><P><P><S><C><L><E><P><L><N><F><C><E><R><S><R><V><C><R><C><A><R><A><A><A><G><P><W><R><G><W><G><R><G><L><S><P><A><H><R><P><P><A><A><Q><A><S><P><P><G><L><S><G><L><V><H><P><S><A><Q><R><P><R><R><L><P><A><G><P><G><R><P><L><P><A><R><L><R><G><P><R><G><V><P><A><G><T><A><V><T><P><N><Y><V><D><N><V><S><A><R><V><A><P><W><C><D><C><G><A><S><G><N><R><R><E><D><C><E><A><F><R><G><L><F><T><R><N><R><C><L><D><G><A><I><Q><A><F><A><S><G><W><P><P><V><L><L><D><Q><L><N><P><Q><G><D><P><E><H><S><L><L><Q><V><S><S><T><G><R><A><L><E><R><R><S><L><L><S><I><L><P><V><L><A><L><P><A><L><L>	Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.<BOP>	Q9GZZ7
Q9NUN5	LMBD1_HUMAN	Nuclear export signal-interacting protein	Homo	<M><A><T><S><G><A><A><S><A><E><L><V><I><G><W><C><I><F><G><L><L><L><L><A><I><L><A><F><C><W><I><Y><V><R><K><Y><Q><S><R><R><E><S><E><V><V><S><T><I><T><A><I><F><S><L><A><I><A><L><I><T><S><A><L><L><P><V><D><I><F><L><V><S><Y><M><K><N><Q><N><G><T><F><K><D><W><A><N><A><N><V><S><R><Q><I><E><D><T><V><L><Y><G><Y><Y><T><L><Y><S><V><I><L><F><C><V><F><F><W><I><P><F><V><Y><F><Y><Y><E><E><K><D><D><D><D><T><S><K><C><T><Q><I><K><T><A><L><K><Y><T><L><G><F><V><V><I><C><A><L><L><L><L><V><G><A><F><V><P><L><N><V><P><N><N><K><N><S><T><E><W><E><K><V><K><S><L><F><E><E><L><G><S><S><H><G><L><A><A><L><S><F><S><I><S><S><L><T><L><I><G><M><L><A><A><I><T><Y><T><A><Y><G><M><S><A><L><P><L><N><L><I><K><G><T><R><S><A><A><Y><E><R><L><E><N><T><E><D><I><E><E><V><E><Q><H><I><Q><T><I><K><S><K><S><K><D><G><R><P><L><P><A><R><D><K><R><A><L><K><Q><F><E><E><R><L><R><T><L><K><K><R><E><R><H><L><E><F><I><E><N><S><W><W><T><K><F><C><G><A><L><R><P><L><K><I><V><W><G><I><F><F><I><L><V><A><L><L><F><V><I><S><L><F><L><S><N><L><D><K><A><L><H><S><A><G><I><D><S><G><F><I><I><F><G><A><N><L><S><N><P><L><N><M><L><L><P><L><L><Q><T><V><F><P><L><D><Y><I><L><I><T><I><I><I><M><Y><F><I><F><T><S><M><A><G><I><R><N><I><G><I><W><F><F><W><I><R><L><Y><K><I><R><R><G><R><T><R><P><Q><A><L><L><F><L><C><M><I><L><L><L><I><V><L><H><T><S><Y><M><I><Y><S><L><A><P><Q><Y><V><M><Y><G><S><Q><N><Y><L><I><E><T><N><I><T><S><D><N><H><K><G><N><S><T><L><S><V><P><K><R><C><D><A><D><A><P><E><D><Q><C><T><V><T><R><T><Y><L><F><L><H><K><F><W><F><F><S><A><A><Y><Y><F><G><N><W><A><F><L><G><V><F><L><I><G><L><I><V><S><C><C><K><G><K><K><S><V><I><E><G><V><D><E><D><S><D><I><S><D><D><E><P><S><V><Y><S><A>	(Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).<BOP>	Q9NUN5
Q16543	CDC37_HUMAN	Hsp90 co-chaperone Cdc37, N-terminally processed	Homo	<M><V><D><Y><S><V><W><D><H><I><E><V><S><D><D><E><D><E><T><H><P><N><I><D><T><A><S><L><F><R><W><R><H><Q><A><R><V><E><R><M><E><Q><F><Q><K><E><K><E><E><L><D><R><G><C><R><E><C><K><R><K><V><A><E><C><Q><R><K><L><K><E><L><E><V><A><E><G><G><K><A><E><L><E><R><L><Q><A><E><A><Q><Q><L><R><K><E><E><R><S><W><E><Q><K><L><E><E><M><R><K><K><E><K><S><M><P><W><N><V><D><T><L><S><K><D><G><F><S><K><S><M><V><N><T><K><P><E><K><T><E><E><D><S><E><E><V><R><E><Q><K><H><K><T><F><V><E><K><Y><E><K><Q><I><K><H><F><G><M><L><R><R><W><D><D><S><Q><K><Y><L><S><D><N><V><H><L><V><C><E><E><T><A><N><Y><L><V><I><W><C><I><D><L><E><V><E><E><K><C><A><L><M><E><Q><V><A><H><Q><T><I><V><M><Q><F><I><L><E><L><A><K><S><L><K><V><D><P><R><A><C><F><R><Q><F><F><T><K><I><K><T><A><D><R><Q><Y><M><E><G><F><N><D><E><L><E><A><F><K><E><R><V><R><G><R><A><K><L><R><I><E><K><A><M><K><E><Y><E><E><E><E><R><K><K><R><L><G><P><G><G><L><D><P><V><E><V><Y><E><S><L><P><E><E><L><Q><K><C><F><D><V><K><D><V><Q><M><L><Q><D><A><I><S><K><M><D><P><T><D><A><K><Y><H><M><Q><R><C><I><D><S><G><L><W><V><P><N><S><K><A><S><E><A><K><E><G><E><E><A><G><P><G><D><P><L><L><E><A><V><P><K><T><G><D><E><K><D><V><S><V>	Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity . Inhibits HSP90AA1 ATPase activity .<BOP>	Q16543
P80294	MT1H_HUMAN	Metallothionein-IH	Homo	<M><D><P><N><C><S><C><E><A><G><G><S><C><A><C><A><G><S><C><K><C><K><K><C><K><C><T><S><C><K><K><S><C><C><S><C><C><P><L><G><C><A><K><C><A><Q><G><C><I><C><K><G><A><S><E><K><C><S><C><C><A>	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.<BOP>	P80294
Q9NVG8	TBC13_HUMAN	TBC1 domain family member 13	Homo	<M><S><S><L><H><K><S><R><I><A><D><F><Q><D><V><L><K><E><P><S><I><A><L><E><K><L><R><E><L><S><F><S><G><I><P><C><E><G><G><L><R><C><L><C><W><K><I><L><L><N><Y><L><P><L><E><R><A><S><W><T><S><I><L><A><K><Q><R><E><L><Y><A><Q><F><L><R><E><M><I><I><Q><P><G><I><A><K><A><N><M><G><V><S><R><E><D><V><T><F><E><D><H><P><L><N><P><N><P><D><S><R><W><N><T><Y><F><K><D><N><E><V><L><L><Q><I><D><K><D><V><R><R><L><C><P><D><I><S><F><F><Q><R><A><T><D><Y><P><C><L><L><I><L><D><P><Q><N><E><F><E><T><L><R><K><R><V><E><Q><T><T><L><K><S><Q><T><V><A><R><N><R><S><G><V><T><N><M><S><S><P><H><K><N><S><V><P><S><S><L><N><E><Y><E><V><L><P><N><G><C><E><A><H><W><E><V><V><E><R><I><L><F><I><Y><A><K><L><N><P><G><I><A><Y><V><Q><G><M><N><E><I><V><G><P><L><Y><Y><T><F><A><T><D><P><N><S><E><W><K><E><H><A><E><A><D><T><F><F><C><F><T><N><L><M><A><E><I><R><D><N><F><I><K><S><L><D><D><S><Q><C><G><I><T><Y><K><M><E><K><V><Y><S><T><L><K><D><K><D><V><E><L><Y><L><K><L><Q><E><Q><N><I><K><P><Q><F><F><A><F><R><W><L><T><L><L><L><S><Q><E><F><L><L><P><D><V><I><R><I><W><D><S><L><F><A><D><D><N><R><F><D><F><L><L><L><V><C><C><A><M><L><M><L><I><R><E><Q><L><L><E><G><D><F><T><V><N><M><R><L><L><Q><D><Y><P><I><T><D><V><C><Q><I><L><Q><K><A><K><E><L><Q><D><S><K>	Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.<BOP>	Q9NVG8
Q5VXJ0	LIPK_HUMAN	Lipase-like abhydrolase domain-containing protein 2	Homo	<M><W><Q><L><L><A><A><A><C><W><M><L><L><L><G><S><M><Y><G><Y><D><K><K><G><N><N><A><N><P><E><A><N><M><N><I><S><Q><I><I><S><Y><W><G><Y><P><Y><E><E><Y><D><V><T><T><K><D><G><Y><I><L><G><I><Y><R><I><P><H><G><R><G><C><P><G><R><T><A><P><K><P><A><V><Y><L><Q><H><G><L><I><A><S><A><S><N><W><I><C><N><L><P><N><N><S><L><A><F><L><L><A><D><S><G><Y><D><V><W><L><G><N><S><R><G><N><T><W><S><R><K><H><L><K><L><S><P><K><S><P><E><Y><W><A><F><S><L><D><E><M><A><K><Y><D><L><P><A><T><I><N><F><I><I><E><K><T><G><Q><K><R><L><Y><Y><V><G><H><S><Q><G><T><T><I><A><F><I><A><F><S><T><N><P><E><L><A><K><K><I><K><I><F><F><A><L><A><P><V><V><T><V><K><Y><T><Q><S><P><M><K><K><L><T><T><L><S><R><R><V><V><K><V><L><F><G><D><K><M><F><H><P><H><T><L><F><D><Q><F><I><A><T><K><V><C><N><R><K><L><F><R><R><I><C><S><N><F><L><F><T><L><S><G><F><D><P><Q><N><L><N><M><S><R><L><D><V><Y><L><S><H><N><P><A><G><T><S><V><Q><N><M><L><H><W><A><Q><A><V><N><S><G><Q><L><Q><A><F><D><W><G><N><S><D><Q><N><M><M><H><F><H><Q><L><T><P><P><L><Y><N><I><T><K><M><E><V><P><T><A><I><W><N><G><G><Q><D><I><V><A><D><P><K><D><V><E><N><L><L><P><Q><I><A><N><L><I><Y><Y><K><L><I><P><H><Y><N><H><V><D><F><Y><L><G><E><D><A><P><Q><E><I><Y><Q><D><L><I><I><L><M><E><E><Y><L><Q><N>	Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.<BOP>	Q5VXJ0
P61925	IPKA_HUMAN	cAMP-dependent protein kinase inhibitor, muscle/brain isoform	Homo	<M><T><D><V><E><T><T><Y><A><D><F><I><A><S><G><R><T><G><R><R><N><A><I><H><D><I><L><V><S><S><A><S><G><N><S><N><E><L><A><L><K><L><A><G><L><D><I><N><K><T><E><G><E><E><D><A><Q><R><S><S><T><E><Q><S><G><E><A><Q><G><E><A><A><K><S><E><S>	Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.<BOP>	P61925
Q9UI32	GLSL_HUMAN	L-glutamine amidohydrolase	Homo	<M><R><S><M><K><A><L><Q><K><A><L><S><R><A><G><S><H><C><G><R><G><G><W><G><H><P><S><R><S><P><L><L><G><G><G><V><R><H><H><L><S><E><A><A><A><Q><G><R><E><T><P><H><S><H><Q><P><Q><H><Q><D><H><D><S><S><E><S><G><M><L><S><R><L><G><D><L><L><F><Y><T><I><A><E><G><Q><E><R><I><P><I><H><K><F><T><T><A><L><K><A><T><G><L><Q><T><S><D><P><R><L><R><D><C><M><S><E><M><H><R><V><V><Q><E><S><S><S><G><G><L><L><D><R><D><L><F><R><K><C><V><S><S><N><I><V><L><L><T><Q><A><F><R><K><K><F><V><I><P><D><F><E><E><F><T><G><H><V><D><R><I><F><E><D><V><K><E><L><T><G><G><K><V><A><A><Y><I><P><Q><L><A><K><S><N><P><D><L><W><G><V><S><L><C><T><V><D><G><Q><R><H><S><V><G><H><T><K><I><P><F><C><L><Q><S><C><V><K><P><L><T><Y><A><I><S><I><S><T><L><G><T><D><Y><V><H><K><F><V><G><K><E><P><S><G><L><R><Y><N><K><L><S><L><N><E><E><G><I><P><H><N><P><M><V><N><A><G><A><I><V><V><S><S><L><I><K><M><D><C><N><K><A><E><K><F><D><F><V><L><Q><Y><L><N><K><M><A><G><N><E><Y><M><G><F><S><N><A><T><F><Q><S><E><K><E><T><G><D><R><N><Y><A><I><G><Y><Y><L><K><E><K><K><C><F><P><K><G><V><D><M><M><A><A><L><D><L><Y><F><Q><L><C><S><V><E><V><T><C><E><S><G><S><V><M><A><A><T><L><A><N><G><G><I><C><P><I><T><G><E><S><V><L><S><A><E><A><V><R><N><T><L><S><L><M><H><S><C><G><M><Y><D><F><S><G><Q><F><A><F><H><V><G><L><P><A><K><S><A><V><S><G><A><I><L><L><V><V><P><N><V><M><G><M><M><C><L><S><P><P><L><D><K><L><G><N><S><H><R><G><T><S><F><C><Q><K><L><V><S><L><F><N><F><H><N><Y><D><N><L><R><H><C><A><R><K><L><D><P><R><R><E><G><A><E><I><R><N><K><T><V><V><N><L><L><F><A><A><Y><S><G><D><V><S><A><L><R><R><F><A><L><S><A><M><D><M><E><Q><K><D><Y><D><S><R><T><A><L><H><V><A><A><A><E><G><H><I><E><V><V><K><F><L><I><E><A><C><K><V><N><P><F><A><K><D><R><W><G><N><I><P><L><D><D><A><V><Q><F><N><H><L><E><V><V><K><L><L><Q><D><Y><Q><D><S><Y><T><L><S><E><T><Q><A><E><A><A><A><E><A><L><S><K><E><N><L><E><S><M><V>	Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<BOP>	Q9UI32
Q5ZPR3	CD276_HUMAN	Costimulatory molecule	Homo	<M><L><R><R><R><G><S><P><G><M><G><V><H><V><G><A><A><L><G><A><L><W><F><C><L><T><G><A><L><E><V><Q><V><P><E><D><P><V><V><A><L><V><G><T><D><A><T><L><C><C><S><F><S><P><E><P><G><F><S><L><A><Q><L><N><L><I><W><Q><L><T><D><T><K><Q><L><V><H><S><F><A><E><G><Q><D><Q><G><S><A><Y><A><N><R><T><A><L><F><P><D><L><L><A><Q><G><N><A><S><L><R><L><Q><R><V><R><V><A><D><E><G><S><F><T><C><F><V><S><I><R><D><F><G><S><A><A><V><S><L><Q><V><A><A><P><Y><S><K><P><S><M><T><L><E><P><N><K><D><L><R><P><G><D><T><V><T><I><T><C><S><S><Y><Q><G><Y><P><E><A><E><V><F><W><Q><D><G><Q><G><V><P><L><T><G><N><V><T><T><S><Q><M><A><N><E><Q><G><L><F><D><V><H><S><I><L><R><V><V><L><G><A><N><G><T><Y><S><C><L><V><R><N><P><V><L><Q><Q><D><A><H><S><S><V><T><I><T><P><Q><R><S><P><T><G><A><V><E><V><Q><V><P><E><D><P><V><V><A><L><V><G><T><D><A><T><L><R><C><S><F><S><P><E><P><G><F><S><L><A><Q><L><N><L><I><W><Q><L><T><D><T><K><Q><L><V><H><S><F><T><E><G><R><D><Q><G><S><A><Y><A><N><R><T><A><L><F><P><D><L><L><A><Q><G><N><A><S><L><R><L><Q><R><V><R><V><A><D><E><G><S><F><T><C><F><V><S><I><R><D><F><G><S><A><A><V><S><L><Q><V><A><A><P><Y><S><K><P><S><M><T><L><E><P><N><K><D><L><R><P><G><D><T><V><T><I><T><C><S><S><Y><R><G><Y><P><E><A><E><V><F><W><Q><D><G><Q><G><V><P><L><T><G><N><V><T><T><S><Q><M><A><N><E><Q><G><L><F><D><V><H><S><V><L><R><V><V><L><G><A><N><G><T><Y><S><C><L><V><R><N><P><V><L><Q><Q><D><A><H><G><S><V><T><I><T><G><Q><P><M><T><F><P><P><E><A><L><W><V><T><V><G><L><S><V><C><L><I><A><L><L><V><A><L><A><F><V><C><W><R><K><I><K><Q><S><C><E><E><E><N><A><G><A><E><D><Q><D><G><E><G><E><G><S><K><T><A><L><Q><P><L><K><H><S><D><S><K><E><D><D><G><Q><E><I><A>	May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.<BOP>	Q5ZPR3
Q16394	EXT1_HUMAN	Putative tumor suppressor protein EXT1	Homo	<M><Q><A><K><K><R><Y><F><I><L><L><S><A><G><S><C><L><A><L><L><F><Y><F><G><G><L><Q><F><R><A><S><R><S><H><S><R><R><E><E><H><S><G><R><N><G><L><H><H><P><S><P><D><H><F><W><P><R><F><P><D><A><L><R><P><F><V><P><W><D><Q><L><E><N><E><D><S><S><V><H><I><S><P><R><Q><K><R><D><A><N><S><S><I><Y><K><G><K><K><C><R><M><E><S><C><F><D><F><T><L><C><K><K><N><G><F><K><V><Y><V><Y><P><Q><Q><K><G><E><K><I><A><E><S><Y><Q><N><I><L><A><A><I><E><G><S><R><F><Y><T><S><D><P><S><Q><A><C><L><F><V><L><S><L><D><T><L><D><R><D><Q><L><S><P><Q><Y><V><H><N><L><R><S><K><V><Q><S><L><H><L><W><N><N><G><R><N><H><L><I><F><N><L><Y><S><G><T><W><P><D><Y><T><E><D><V><G><F><D><I><G><Q><A><M><L><A><K><A><S><I><S><T><E><N><F><R><P><N><F><D><V><S><I><P><L><F><S><K><D><H><P><R><T><G><G><E><R><G><F><L><K><F><N><T><I><P><P><L><R><K><Y><M><L><V><F><K><G><K><R><Y><L><T><G><I><G><S><D><T><R><N><A><L><Y><H><V><H><N><G><E><D><V><V><L><L><T><T><C><K><H><G><K><D><W><Q><K><H><K><D><S><R><C><D><R><D><N><T><E><Y><E><K><Y><D><Y><R><E><M><L><H><N><A><T><F><C><L><V><P><R><G><R><R><L><G><S><F><R><F><L><E><A><L><Q><A><A><C><V><P><V><M><L><S><N><G><W><E><L><P><F><S><E><V><I><N><W><N><Q><A><A><V><I><G><D><E><R><L><L><L><Q><I><P><S><T><I><R><S><I><H><Q><D><K><I><L><A><L><R><Q><Q><T><Q><F><L><W><E><A><Y><F><S><S><V><E><K><I><V><L><T><T><L><E><I><I><Q><D><R><I><F><K><H><I><S><R><N><S><L><I><W><N><K><H><P><G><G><L><F><V><L><P><Q><Y><S><S><Y><L><G><D><F><P><Y><Y><Y><A><N><L><G><L><K><P><P><S><K><F><T><A><V><I><H><A><V><T><P><L><V><S><Q><S><Q><P><V><L><K><L><L><V><A><A><A><K><S><Q><Y><C><A><Q><I><I><V><L><W><N><C><D><K><P><L><P><A><K><H><R><W><P><A><T><A><V><P><V><V><V><I><E><G><E><S><K><V><M><S><S><R><F><L><P><Y><D><N><I><I><T><D><A><V><L><S><L><D><E><D><T><V><L><S><T><T><E><V><D><F><A><F><T><V><W><Q><S><F><P><E><R><I><V><G><Y><P><A><R><S><H><F><W><D><N><S><K><E><R><W><G><Y><T><S><K><W><T><N><D><Y><S><M><V><L><T><G><A><A><I><Y><H><K><Y><Y><H><Y><L><Y><S><H><Y><L><P><A><S><L><K><N><M><V><D><Q><L><A><N><C><E><D><I><L><M><N><F><L><V><S><A><V><T><K><L><P><P><I><K><V><T><Q><K><K><Q><Y><K><E><T><M><M><G><Q><T><S><R><A><S><R><W><A><D><P><D><H><F><A><Q><R><Q><S><C><M><N><T><F><A><S><W><F><G><Y><M><P><L><I><H><S><Q><M><R><L><D><P><V><L><F><K><D><Q><V><S><I><L><R><K><K><Y><R><D><I><E><R><L>	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan .<BOP>	Q16394
Q6VVX0	CP2R1_HUMAN	Cytochrome P450 2R1	Homo	<M><W><K><L><W><R><A><E><E><G><A><A><A><L><G><G><A><L><F><L><L><L><F><A><L><G><V><R><Q><L><L><K><Q><R><R><P><M><G><F><P><P><G><P><P><G><L><P><F><I><G><N><I><Y><S><L><A><A><S><S><E><L><P><H><V><Y><M><R><K><Q><S><Q><V><Y><G><E><I><F><S><L><D><L><G><G><I><S><T><V><V><L><N><G><Y><D><V><V><K><E><C><L><V><H><Q><S><E><I><F><A><D><R><P><C><L><P><L><F><M><K><M><T><K><M><G><G><L><L><N><S><R><Y><G><R><G><W><V><D><H><R><R><L><A><V><N><S><F><R><Y><F><G><Y><G><Q><K><S><F><E><S><K><I><L><E><E><T><K><F><F><N><D><A><I><E><T><Y><K><G><R><P><F><D><F><K><Q><L><I><T><N><A><V><S><N><I><T><N><L><I><I><F><G><E><R><F><T><Y><E><D><T><D><F><Q><H><M><I><E><L><F><S><E><N><V><E><L><A><A><S><A><S><V><F><L><Y><N><A><F><P><W><I><G><I><L><P><F><G><K><H><Q><Q><L><F><R><N><A><A><V><V><Y><D><F><L><S><R><L><I><E><K><A><S><V><N><R><K><P><Q><L><P><Q><H><F><V><D><A><Y><L><D><E><M><D><Q><G><K><N><D><P><S><S><T><F><S><K><E><N><L><I><F><S><V><G><E><L><I><I><A><G><T><E><T><T><T><N><V><L><R><W><A><I><L><F><M><A><L><Y><P><N><I><Q><G><Q><V><Q><K><E><I><D><L><I><M><G><P><N><G><K><P><S><W><D><D><K><C><K><M><P><Y><T><E><A><V><L><H><E><V><L><R><F><C><N><I><V><P><L><G><I><F><H><A><T><S><E><D><A><V><V><R><G><Y><S><I><P><K><G><T><T><V><I><T><N><L><Y><S><V><H><F><D><E><K><Y><W><R><D><P><E><V><F><H><P><E><R><F><L><D><S><S><G><Y><F><A><K><K><E><A><L><V><P><F><S><L><G><R><R><H><C><L><G><E><H><L><A><R><M><E><M><F><L><F><F><T><A><L><L><Q><R><F><H><L><H><F><P><H><E><L><V><P><D><L><K><P><R><L><G><M><T><L><Q><P><Q><P><Y><L><I><C><A><E><R><R>	A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) . Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) .<BOP>	Q6VVX0
P21583	SCF_HUMAN	Soluble KIT ligand	Homo	<M><K><K><T><Q><T><W><I><L><T><C><I><Y><L><Q><L><L><L><F><N><P><L><V><K><T><E><G><I><C><R><N><R><V><T><N><N><V><K><D><V><T><K><L><V><A><N><L><P><K><D><Y><M><I><T><L><K><Y><V><P><G><M><D><V><L><P><S><H><C><W><I><S><E><M><V><V><Q><L><S><D><S><L><T><D><L><L><D><K><F><S><N><I><S><E><G><L><S><N><Y><S><I><I><D><K><L><V><N><I><V><D><D><L><V><E><C><V><K><E><N><S><S><K><D><L><K><K><S><F><K><S><P><E><P><R><L><F><T><P><E><E><F><F><R><I><F><N><R><S><I><D><A><F><K><D><F><V><V><A><S><E><T><S><D><C><V><V><S><S><T><L><S><P><E><K><D><S><R><V><S><V><T><K><P><F><M><L><P><P><V><A><A><S><S><L><R><N><D><S><S><S><S><N><R><K><A><K><N><P><P><G><D><S><S><L><H><W><A><A><M><A><L><P><A><L><F><S><L><I><I><G><F><A><F><G><A><L><Y><W><K><K><R><Q><P><S><L><T><R><A><V><E><N><I><Q><I><N><E><E><D><N><E><I><S><M><L><Q><E><K><E><R><E><F><Q><E><V>	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.<BOP>	P21583
P43359	MAGA5_HUMAN	MAGE-5 antigen	Homo	<M><S><L><E><Q><K><S><Q><H><C><K><P><E><E><G><L><D><T><Q><E><E><A><L><G><L><V><G><V><Q><A><A><T><T><E><E><Q><E><A><V><S><S><S><S><P><L><V><P><G><T><L><G><E><V><P><A><A><G><S><P><G><P><L><K><S><P><Q><G><A><S><A><I><P><T><A><I><D><F><T><L><W><R><Q><S><I><K><G><S><S><N><Q><E><E><E><G><P><S><T><S><P><D><P><E><S><V><F><R><A><A><L><S><K><K><V><A><D><L><I><H><F><L><L><L><K><Y>	May negatively regulates apoptosis.<BOP>	P43359
P10415	BCL2_HUMAN	Apoptosis regulator Bcl-2	Homo	<M><A><H><A><G><R><T><G><Y><D><N><R><E><I><V><M><K><Y><I><H><Y><K><L><S><Q><R><G><Y><E><W><D><A><G><D><V><G><A><A><P><P><G><A><A><P><A><P><G><I><F><S><S><Q><P><G><H><T><P><H><P><A><A><S><R><D><P><V><A><R><T><S><P><L><Q><T><P><A><A><P><G><A><A><A><G><P><A><L><S><P><V><P><P><V><V><H><L><T><L><R><Q><A><G><D><D><F><S><R><R><Y><R><R><D><F><A><E><M><S><S><Q><L><H><L><T><P><F><T><A><R><G><R><F><A><T><V><V><E><E><L><F><R><D><G><V><N><W><G><R><I><V><A><F><F><E><F><G><G><V><M><C><V><E><S><V><N><R><E><M><S><P><L><V><D><N><I><A><L><W><M><T><E><Y><L><N><R><H><L><H><T><W><I><Q><D><N><G><G><W><D><A><F><V><E><L><Y><G><P><S><M><R><P><L><F><D><F><S><W><L><S><L><K><T><L><L><S><L><A><L><V><G><A><C><I><T><L><G><A><Y><L><G><H><K>	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells . Regulates cell death by controlling the mitochondrial membrane permeability . Appears to function in a feedback loop system with caspases . Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release .<BOP>	P10415
O15527	OGG1_HUMAN	DNA-(apurinic or apyrimidinic site) lyase	Homo	<M><P><A><R><A><L><L><P><R><R><M><G><H><R><T><L><A><S><T><P><A><L><W><A><S><I><P><C><P><R><S><E><L><R><L><D><L><V><L><P><S><G><Q><S><F><R><W><R><E><Q><S><P><A><H><W><S><G><V><L><A><D><Q><V><W><T><L><T><Q><T><E><E><Q><L><H><C><T><V><Y><R><G><D><K><S><Q><A><S><R><P><T><P><D><E><L><E><A><V><R><K><Y><F><Q><L><D><V><T><L><A><Q><L><Y><H><H><W><G><S><V><D><S><H><F><Q><E><V><A><Q><K><F><Q><G><V><R><L><L><R><Q><D><P><I><E><C><L><F><S><F><I><C><S><S><N><N><N><I><A><R><I><T><G><M><V><E><R><L><C><Q><A><F><G><P><R><L><I><Q><L><D><D><V><T><Y><H><G><F><P><S><L><Q><A><L><A><G><P><E><V><E><A><H><L><R><K><L><G><L><G><Y><R><A><R><Y><V><S><A><S><A><R><A><I><L><E><E><Q><G><G><L><A><W><L><Q><Q><L><R><E><S><S><Y><E><E><A><H><K><A><L><C><I><L><P><G><V><G><T><K><V><A><D><C><I><C><L><M><A><L><D><K><P><Q><A><V><P><V><D><V><H><M><W><H><I><A><Q><R><D><Y><S><W><H><P><T><T><S><Q><A><K><G><P><S><P><Q><T><N><K><E><L><G><N><F><F><R><S><L><W><G><P><Y><A><G><W><A><Q><A><V><L><F><S><A><D><L><R><Q><S><R><H><A><Q><E><P><P><A><K><R><R><K><G><S><K><G><P><E><G>	DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.<BOP>	O15527
Q86X67	NUD13_HUMAN	Protein KiSS-16	Homo	<M><S><L><Y><C><G><I><A><C><R><R><K><F><F><W><C><Y><R><L><L><S><T><Y><V><T><K><T><R><Y><L><F><E><L><K><E><D><D><D><A><C><K><K><A><Q><Q><T><G><A><F><Y><L><F><H><S><L><A><P><L><L><Q><T><S><A><H><Q><Y><L><A><P><R><H><S><L><L><E><L><E><R><L><L><G><K><F><G><Q><D><A><Q><R><I><E><D><S><V><L><I><G><C><S><E><Q><Q><E><A><W><F><A><L><D><L><G><L><D><S><S><F><S><I><S><A><S><L><H><K><P><E><M><E><T><E><L><K><G><S><F><I><E><L><R><K><A><L><F><Q><L><N><A><R><D><A><S><L><L><S><T><A><Q><A><L><L><R><W><H><D><A><H><Q><F><C><S><R><S><G><Q><P><T><K><K><N><V><A><G><S><K><R><V><C><P><S><N><N><I><I><Y><Y><P><Q><M><A><P><V><A><I><T><L><V><S><D><G><T><R><C><L><L><A><R><Q><S><S><F><P><K><G><M><Y><S><A><L><A><G><F><C><D><I><G><E><S><V><E><E><T><I><R><R><E><V><A><E><E><V><G><L><E><V><E><S><L><Q><Y><Y><A><S><Q><H><W><P><F><P><S><G><S><L><M><I><A><C><H><A><T><V><K><P><G><Q><T><E><I><Q><V><N><L><R><E><L><E><T><A><A><W><F><S><H><D><E><V><A><T><A><L><K><R><K><G><P><Y><T><Q><Q><Q><N><G><T><F><P><F><W><L><P><P><K><L><A><I><S><H><Q><L><I><K><E><W><V><E><K><Q><T><C><S><S><L><P><A>	NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP. Has a marked preference for the reduced pyridine nucleotides. Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs.<BOP>	Q86X67
Q8TDV0	GP151_HUMAN	Galanin-receptor-like protein	Homo	<M><L><A><A><A><F><A><D><S><N><S><S><S><M><N><V><S><F><A><H><L><H><F><A><G><G><Y><L><P><S><D><S><Q><D><W><R><T><I><I><P><A><L><L><V><A><V><C><L><V><G><F><V><G><N><L><C><V><I><G><I><L><L><H><N><A><W><K><G><K><P><S><M><I><H><S><L><I><L><N><L><S><L><A><D><L><S><L><L><L><F><S><A><P><I><R><A><T><A><Y><S><K><S><V><W><D><L><G><W><F><V><C><K><S><S><D><W><F><I><H><T><C><M><A><A><K><S><L><T><I><V><V><V><A><K><V><C><F><M><Y><A><S><D><P><A><K><Q><V><S><I><H><N><Y><T><I><W><S><V><L><V><A><I><W><T><V><A><S><L><L><P><L><P><E><W><F><F><S><T><I><R><H><H><E><G><V><E><M><C><L><V><D><V><P><A><V><A><E><E><F><M><S><M><F><G><K><L><Y><P><L><L><A><F><G><L><P><L><F><F><A><S><F><Y><F><W><R><A><Y><D><Q><C><K><K><R><G><T><K><T><Q><N><L><R><N><Q><I><R><S><K><Q><V><T><V><M><L><L><S><I><A><I><I><S><A><L><L><W><L><P><E><W><V><A><W><L><W><V><W><H><L><K><A><A><G><P><A><P><P><Q><G><F><I><A><L><S><Q><V><L><M><F><S><I><S><S><A><N><P><L><I><F><L><V><M><S><E><E><F><R><E><G><L><K><G><V><W><K><W><M><I><T><K><K><P><P><T><V><S><E><S><Q><E><T><P><A><G><N><S><E><G><L><P><D><K><V><P><S><P><E><S><P><A><S><I><P><E><K><E><K><P><S><S><P><S><S><G><K><G><K><T><E><K><A><E><I><P><I><L><P><D><V><E><Q><F><W><H><E><R><D><T><V><P><S><V><Q><D><N><D><P><I><P><W><E><H><E><D><Q><E><T><G><E><G><V><K>	Proton-sensing G-protein coupled receptor.<BOP>	Q8TDV0
A6NNB3	IFM5_HUMAN	Dispanin subfamily A member 1	Homo	<M><D><T><A><Y><P><R><E><D><T><R><A><P><T><P><S><K><A><G><A><H><T><A><L><T><L><G><A><P><H><P><P><P><R><D><H><L><I><W><S><V><F><S><T><L><Y><L><N><L><C><C><L><G><F><L><A><L><A><Y><S><I><K><A><R><D><Q><K><V><V><G><D><L><E><A><A><R><R><F><G><S><K><A><K><C><Y><N><I><L><A><A><M><W><T><L><V><P><P><L><L><L><L><G><L><V><V><T><G><A><L><H><L><A><R><L><A><K><D><S><A><A><F><F><S><T><K><F><D><D><A><D><Y><D>	Required for normal bone mineralization.<BOP>	A6NNB3
Q8TE68	ES8L1_HUMAN	Epidermal growth factor receptor pathway substrate 8-related protein 1	Homo	<M><S><T><A><T><G><P><E><A><A><P><K><P><S><A><K><S><I><Y><E><Q><R><K><R><Y><S><T><V><V><M><A><D><V><S><Q><Y><P><V><N><H><L><V><T><F><C><L><G><E><D><D><G><V><H><T><V><E><D><A><S><R><K><L><A><V><M><D><S><Q><G><R><V><W><A><Q><E><M><L><L><R><V><S><P><D><H><V><T><L><L><D><P><A><S><K><E><E><L><E><S><Y><P><L><G><A><I><V><R><C><D><A><V><M><P><P><G><R><S><R><S><L><L><L><L><V><C><Q><E><P><E><R><A><Q><P><D><V><H><F><F><Q><G><L><R><L><G><A><E><L><I><R><E><D><I><Q><G><A><L><H><N><Y><R><S><G><R><G><E><R><R><A><A><A><L><R><A><T><Q><E><E><L><Q><R><D><R><S><P><A><A><E><T><P><P><L><Q><R><R><P><S><V><R><A><V><I><S><T><V><E><R><G><A><G><R><G><R><P><Q><A><K><P><I><P><E><A><E><E><A><Q><R><P><E><P><V><G><T><S><S><N><A><D><S><A><S><P><D><L><G><P><R><G><P><D><L><A><V><L><Q><A><E><R><E><V><D><I><L><N><H><V><F><D><D><V><E><S><F><V><S><R><L><Q><K><S><A><E><A><A><R><V><L><E><H><R><E><R><G><R><R><S><R><R><R><A><A><G><E><G><L><L><T><L><R><A><K><P><P><S><E><A><E><Y><T><D><V><L><Q><K><I><K><Y><A><F><S><L><L><A><R><L><R><G><N><I><A><D><P><S><S><P><E><L><L><H><F><L><F><G><P><L><Q><M><I><V><N><T><S><G><G><P><E><F><A><S><S><V><R><R><P><H><L><T><S><D><A><V><A><L><L><R><D><N><V><T><P><R><E><N><E><L><W><T><S><L><G><D><S><W><T><R><P><G><L><E><L><S><P><E><E><G><P><P><Y><R><P><E><F><F><S><G><W><E><P><P><V><T><D><P><Q><S><R><A><W><E><D><P><V><E><K><Q><L><Q><H><E><R><R><R><R><Q><Q><S><A><P><Q><V><A><V><N><G><H><R><D><L><E><P><E><S><E><P><Q><L><E><S><E><T><A><G><K><W><V><L><C><N><Y><D><F><Q><A><R><N><S><S><E><L><S><V><K><Q><R><D><V><L><E><V><L><D><D><S><R><K><W><W><K><V><R><D><P><A><G><Q><E><G><Y><V><P><Y><N><I><L><T><P><Y><P><G><P><R><L><H><H><S><Q><S><P><A><R><S><L><N><S><T><P><P><P><P><P><A><P><A><P><A><P><P><P><A><L><A><R><P><R><W><D><R><P><R><W><D><S><C><D><S><L><N><G><L><D><P><S><E><K><E><K><F><S><Q><M><L><I><V><N><E><E><L><Q><A><R><L><A><Q><G><R><S><G><P><S><R><A><V><P><G><P><R><A><P><E><P><Q><L><S><P><G><S><D><A><S><E><V><R><A><W><L><Q><A><K><G><F><S><S><G><T><V><D><A><L><G><V><L><T><G><A><Q><L><F><S><L><Q><K><E><E><L><R><A><V><S><P><E><E><G><A><R><V><Y><S><Q><V><T><V><Q><R><S><L><L><E><D><K><E><K><V><S><E><L><E><A><V><M><E><K><Q><K><K><K><V><E><G><E><V><E><M><E><V><I>	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<BOP>	Q8TE68
Q8NGL0	OR5L2_HUMAN	Olfactory receptor OR11-153	Homo	<M><G><K><E><N><C><T><T><V><A><E><F><I><L><L><G><L><S><D><V><P><E><L><R><V><C><L><F><L><L><F><L><L><I><Y><G><V><T><L><L><A><N><L><G><M><T><A><L><I><Q><V><S><S><R><L><H><T><P><V><Y><F><F><L><S><H><L><S><F><V><D><F><C><Y><S><S><I><I><V><P><K><M><L><A><N><I><F><N><K><D><K><A><I><S><F><L><G><C><M><V><Q><F><Y><L><F><C><T><C><G><V><T><E><V><F><L><L><A><V><M><A><Y><D><R><F><V><A><I><C><N><P><L><L><Y><M><V><T><M><S><Q><K><L><R><V><E><L><T><S><C><C><Y><F><C><G><T><V><C><S><L><I><H><S><S><L><A><L><R><I><L><F><Y><R><S><N><V><I><N><H><F><F><C><D><L><P><P><L><L><S><L><A><C><S><D><V><T><V><N><E><T><L><L><F><L><V><A><T><L><N><E><S><V><T><I><M><I><I><L><T><S><Y><L><L><I><L><T><T><I><L><K><I><H><S><A><E><S><R><H><K><A><F><S><T><C><A><S><H><L><T><A><I><T><V><S><H><G><T><I><L><Y><I><Y><C><R><P><S><S><G><N><S><G><D><V><D><K><V><A><T><V><F><Y><T><V><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><N><K><A><L><R><K><V><M><G><S><K><I><H><S>	Odorant receptor.<BOP>	Q8NGL0
Q9NUG6	PDRG1_HUMAN	p53 and DNA damage-regulated protein 1	Homo	<M><L><S><P><E><A><E><R><V><L><R><Y><L><V><E><V><E><E><L><A><E><E><V><L><A><D><K><R><Q><I><V><D><L><D><T><K><R><N><Q><N><R><E><G><L><R><A><L><Q><K><D><L><S><L><S><E><D><V><M><V><C><F><G><N><M><F><I><K><M><P><H><P><E><T><K><E><M><I><E><K><D><Q><D><H><L><D><K><E><I><E><K><L><R><K><Q><L><K><V><K><V><N><R><L><F><E><A><Q><G><K><P><E><L><K><G><F><N><L><N><P><L><N><Q><D><E><L><K><A><L><K><V><I><L><K><G>	May play a role in chaperone-mediated protein folding.<BOP>	Q9NUG6
Q70EL3	UBP50_HUMAN	Inactive ubiquitin-specific peptidase 50	Homo	<M><T><S><Q><P><S><L><P><A><D><D><F><D><I><Y><H><V><L><A><E><C><T><D><Y><Y><D><T><L><P><V><K><E><A><D><G><N><Q><P><H><F><Q><G><V><T><G><L><W><N><L><G><N><T><C><C><V><N><A><I><S><Q><C><L><C><S><I><L><P><L><V><E><Y><F><L><T><G><K><Y><I><T><A><L><Q><K><F><L><L><P><S><D><C><S><E><V><A><T><A><F><A><Y><L><M><T><D><M><W><L><G><D><S><D><C><V><S><P><E><I><F><W><S><A><L><G><N><L><Y><P><A><F><T><K><K><M><Q><Q><D><A><Q><E><F><L><I><C><V><L><N><E><L><H><E><A><L><K><K><Y><H><Y><S><R><R><R><S><Y><E><K><G><S><T><Q><R><C><C><R><K><W><I><T><T><E><T><S><I><I><T><Q><L><F><E><E><Q><L><N><Y><S><I><V><C><L><K><C><E><K><C><T><Y><K><N><E><V><F><T><V><F><S><L><P><I><P><S><K><Y><E><C><S><L><R><D><C><L><Q><C><F><F><Q><Q><D><A><L><T><W><N><N><E><I><H><C><S><F><C><E><T><K><Q><E><T><A><V><R><A><S><I><S><K><A><P><K><I><I><I><F><H><L><K><R><F><D><I><Q><G><T><T><K><R><K><L><R><T><D><I><H><Y><P><L><T><N><L><D><L><T><P><Y><I><C><S><I><F><R><K><Y><P><K><Y><N><L><C><A><V><V><N><H><F><G><D><L><D><G><G><H><Y><T><A><F><C><K><N><S><V><T><Q><A>	Has no peptidase activity.<BOP>	Q70EL3
Q693B1	KCD11_HUMAN	RING-type E3 ubiquitin transferase subunit KCTD11	Homo	<M><L><G><A><M><F><R><A><G><T><P><M><P><P><N><L><N><S><Q><G><G><G><H><Y><F><I><D><R><D><G><K><A><F><R><H><I><L><N><F><L><R><L><G><R><L><D><L><P><R><G><Y><G><E><T><A><L><L><R><A><E><A><D><F><Y><Q><I><R><P><L><L><D><A><L><R><E><L><E><A><S><Q><G><T><P><A><P><T><A><A><L><L><H><A><D><V><D><V><S><P><R><L><V><H><F><S><A><R><R><G><P><H><H><Y><E><L><S><S><V><Q><V><D><T><F><R><A><N><L><F><C><T><D><S><E><C><L><G><A><L><R><A><R><F><G><V><A><S><G><D><R><A><E><G><S><P><H><F><H><L><E><W><A><P><R><P><V><E><L><P><E><V><E><Y><G><R><L><G><L><Q><P><L><W><T><G><G><P><G><E><R><R><E><V><V><G><T><P><S><F><L><E><E><V><L><R><V><A><L><E><H><G><F><R><L><D><S><V><F><P><D><P><E><D><L><L><N><S><R><S><L><R><F><V><R><H>	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.<BOP>	Q693B1
Q9UHC3	ASIC3_HUMAN	Testis sodium channel 1	Homo	<M><K><P><T><S><G><P><E><E><A><R><R><P><A><S><D><I><R><V><F><A><S><N><C><S><M><H><G><L><G><H><V><F><G><P><G><S><L><S><L><R><R><G><M><W><A><A><A><V><V><L><S><V><A><T><F><L><Y><Q><V><A><E><R><V><R><Y><Y><R><E><F><H><H><Q><T><A><L><D><E><R><E><S><H><R><L><I><F><P><A><V><T><L><C><N><I><N><P><L><R><R><S><R><L><T><P><N><D><L><H><W><A><G><S><A><L><L><G><L><D><P><A><E><H><A><A><F><L><R><A><L><G><R><P><P><A><P><P><G><F><M><P><S><P><T><F><D><M><A><Q><L><Y><A><R><A><G><H><S><L><D><D><M><L><L><D><C><R><F><R><G><Q><P><C><G><P><E><N><F><T><T><I><F><T><R><M><G><K><C><Y><T><F><N><S><G><A><D><G><A><E><L><L><T><T><T><R><G><G><M><G><N><G><L><D><I><M><L><D><V><Q><Q><E><E><Y><L><P><V><W><R><D><N><E><E><T><P><F><E><V><G><I><R><V><Q><I><H><S><Q><E><E><P><P><I><I><D><Q><L><G><L><G><V><S><P><G><Y><Q><T><F><V><S><C><Q><Q><Q><Q><L><S><F><L><P><P><P><W><G><D><C><S><S><A><S><L><N><P><N><Y><E><P><E><P><S><D><P><L><G><S><P><S><P><S><P><S><P><P><Y><T><L><M><G><C><R><L><A><C><E><T><R><Y><V><A><R><K><C><G><C><R><M><V><Y><M><P><G><D><V><P><V><C><S><P><Q><Q><Y><K><N><C><A><H><P><A><I><D><A><M><L><R><K><D><S><C><A><C><P><N><P><C><A><S><T><R><Y><A><K><E><L><S><M><V><R><I><P><S><R><A><A><A><R><F><L><A><R><K><L><N><R><S><E><A><Y><I><A><E><N><V><L><A><L><D><I><F><F><E><A><L><N><Y><E><T><V><E><Q><K><K><A><Y><E><M><S><E><L><L><G><D><I><G><G><Q><M><G><L><F><I><G><A><S><L><L><T><I><L><E><I><L><D><Y><L><C><E><V><F><R><D><K><V><L><G><Y><F><W><N><R><Q><H><S><Q><R><H><S><S><T><N><L><L><Q><E><G><L><G><S><H><R><T><Q><V><P><H><L><S><L><G><P><R><P><P><T><P><P><C><A><V><T><K><T><L><S><A><S><H><R><T><C><Y><L><V><T><Q><L>	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.<BOP>	Q9UHC3
Q13705	AVR2B_HUMAN	Activin receptor type IIB	Homo	<M><T><A><P><W><V><A><L><A><L><L><W><G><S><L><C><A><G><S><G><R><G><E><A><E><T><R><E><C><I><Y><Y><N><A><N><W><E><L><E><R><T><N><Q><S><G><L><E><R><C><E><G><E><Q><D><K><R><L><H><C><Y><A><S><W><R><N><S><S><G><T><I><E><L><V><K><K><G><C><W><L><D><D><F><N><C><Y><D><R><Q><E><C><V><A><T><E><E><N><P><Q><V><Y><F><C><C><C><E><G><N><F><C><N><E><R><F><T><H><L><P><E><A><G><G><P><E><V><T><Y><E><P><P><P><T><A><P><T><L><L><T><V><L><A><Y><S><L><L><P><I><G><G><L><S><L><I><V><L><L><A><F><W><M><Y><R><H><R><K><P><P><Y><G><H><V><D><I><H><E><D><P><G><P><P><P><P><S><P><L><V><G><L><K><P><L><Q><L><L><E><I><K><A><R><G><R><F><G><C><V><W><K><A><Q><L><M><N><D><F><V><A><V><K><I><F><P><L><Q><D><K><Q><S><W><Q><S><E><R><E><I><F><S><T><P><G><M><K><H><E><N><L><L><Q><F><I><A><A><E><K><R><G><S><N><L><E><V><E><L><W><L><I><T><A><F><H><D><K><G><S><L><T><D><Y><L><K><G><N><I><I><T><W><N><E><L><C><H><V><A><E><T><M><S><R><G><L><S><Y><L><H><E><D><V><P><W><C><R><G><E><G><H><K><P><S><I><A><H><R><D><F><K><S><K><N><V><L><L><K><S><D><L><T><A><V><L><A><D><F><G><L><A><V><R><F><E><P><G><K><P><P><G><D><T><H><G><Q><V><G><T><R><R><Y><M><A><P><E><V><L><E><G><A><I><N><F><Q><R><D><A><F><L><R><I><D><M><Y><A><M><G><L><V><L><W><E><L><V><S><R><C><K><A><A><D><G><P><V><D><E><Y><M><L><P><F><E><E><E><I><G><Q><H><P><S><L><E><E><L><Q><E><V><V><V><H><K><K><M><R><P><T><I><K><D><H><W><L><K><H><P><G><L><A><Q><L><C><V><T><I><E><E><C><W><D><H><D><A><E><A><R><L><S><A><G><C><V><E><E><R><V><S><L><I><R><R><S><V><N><G><T><T><S><D><C><L><V><S><L><V><T><S><V><T><N><V><D><L><P><P><K><E><S><S><I>	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphory	Q13705
Q14952	KI2S3_HUMAN	Natural killer-associated transcript 7	Homo	<M><S><L><M><V><I><S><M><A><C><V><G><F><F><W><L><Q><G><A><W><P><H><E><G><F><R><R><K><P><S><L><L><A><H><P><G><R><L><V><K><S><E><E><T><V><I><L><Q><C><W><S><D><V><M><F><E><H><F><L><L><H><R><E><G><T><F><N><D><T><L><R><L><I><G><E><H><I><D><G><V><S><K><A><N><F><S><I><G><R><M><R><Q><D><L><A><G><T><Y><R><C><Y><G><S><V><P><H><S><P><Y><Q><F><S><A><P><S><D><P><L><D><I><V><I><T><G><L><Y><E><K><P><S><L><S><A><Q><P><G><P><T><V><L><A><G><E><S><V><T><L><S><C><S><S><W><S><S><Y><D><M><Y><H><L><S><T><E><G><E><A><H><E><R><R><F><S><A><G><P><K><V><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><Q><G><G><T><Y><R><C><F><G><S><F><H><D><S><P><Y><E><W><S><K><S><S><D><P><L><L><V><S><V><T><G><N><P><S><N><S><W><P><S><P><T><E><P><S><S><K><T><G><N><P><R><H><L><H><V><L><I><G><T><S><V><V><K><L><P><F><T><I><L><L><F><F><L><L><H><R><W><C><S><D><K><K><N><A><S><V><M><D><Q><G><P><A><G><N><R><T><V><N><R><E><D><S><D><E><Q><D><H><Q><E><V><S><Y><A>	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.<BOP>	Q14952
Q9BZD2	S29A3_HUMAN	Solute carrier family 29 member 3	Homo	<M><A><V><V><S><E><D><D><F><Q><H><S><S><N><S><T><Y><R><T><T><S><S><S><L><R><A><D><Q><E><A><L><L><E><K><L><L><D><R><P><P><P><G><L><Q><R><P><E><D><R><F><C><G><T><Y><I><I><F><F><S><L><G><I><G><S><L><L><P><W><N><F><F><I><T><A><K><E><Y><W><M><F><K><L><R><N><S><S><S><P><A><T><G><E><D><P><E><G><S><D><I><L><N><Y><F><E><S><Y><L><A><V><A><S><T><V><P><S><M><L><C><L><V><A><N><F><L><L><V><N><R><V><A><V><H><I><R><V><L><A><S><L><T><V><I><L><A><I><F><M><V><I><T><A><L><V><K><V><D><T><S><S><W><T><R><G><F><F><A><V><T><I><V><C><M><V><I><L><S><G><A><S><T><V><F><S><S><S><I><Y><G><M><T><G><S><F><P><M><R><N><S><Q><A><L><I><S><G><G><A><M><G><G><T><V><S><A><V><A><S><L><V><D><L><A><A><S><S><D><V><R><N><S><A><L><A><F><F><L><T><A><T><V><F><L><V><L><C><M><G><L><Y><L><L><L><S><R><L><E><Y><A><R><Y><Y><M><R><P><V><L><A><A><H><V><F><S><G><E><E><E><L><P><Q><D><S><L><S><A><P><S><V><A><S><R><F><I><D><S><H><T><P><P><L><R><P><I><L><K><K><T><A><S><L><G><F><C><V><T><Y><V><F><F><I><T><S><L><I><Y><P><A><I><C><T><N><I><E><S><L><N><K><G><S><G><S><L><W><T><T><K><F><F><I><P><L><T><T><F><L><L><Y><N><F><A><D><L><C><G><R><Q><L><T><A><W><I><Q><V><P><G><P><N><S><K><A><L><P><G><F><V><L><L><R><T><C><L><I><P><L><F><V><L><C><N><Y><Q><P><R><V><H><L><K><T><V><V><F><Q><S><D><V><Y><P><A><L><L><S><S><L><L><G><L><S><N><G><Y><L><S><T><L><A><L><L><Y><G><P><K><I><V><P><R><E><L><A><E><A><T><G><V><V><M><S><F><Y><V><C><L><G><L><T><L><G><S><A><C><S><T><L><L><V><H><L><I>	Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.<BOP>	Q9BZD2
Q9Y5Y3	GPR45_HUMAN	PSP24-alpha	Homo	<M><A><C><N><S><T><S><L><E><A><Y><T><Y><L><L><L><N><T><S><N><A><S><D><S><G><S><T><Q><L><P><A><P><L><R><I><S><L><A><I><V><M><L><L><M><T><V><V><G><F><L><G><N><T><V><V><C><I><I><V><Y><Q><R><P><A><M><R><S><A><I><N><L><L><L><A><T><L><A><F><S><D><I><M><L><S><L><C><C><M><P><F><T><A><V><T><L><I><T><V><R><W><H><F><G><D><H><F><C><R><L><S><A><T><L><Y><W><F><F><V><L><E><G><V><A><I><L><L><I><I><S><V><D><R><F><L><I><I><V><Q><R><Q><D><K><L><N><P><R><R><A><K><V><I><I><A><V><S><W><V><L><S><F><C><I><A><G><P><S><L><T><G><W><T><L><V><E><V><P><A><R><A><P><Q><C><V><L><G><Y><T><E><L><P><A><D><R><A><Y><V><V><T><L><V><V><A><V><F><F><A><P><F><G><V><M><L><C><A><Y><M><C><I><L><N><T><V><R><K><N><A><V><R><V><H><N><Q><S><D><S><L><D><L><R><Q><L><T><R><A><G><L><R><R><L><Q><R><Q><Q><Q><V><S><V><D><L><S><F><K><T><K><A><F><T><T><I><L><I><L><F><V><G><F><S><L><C><W><L><P><H><S><V><Y><S><L><L><S><V><F><S><Q><R><F><Y><C><G><S><S><F><Y><A><T><S><T><C><V><L><W><L><S><Y><L><K><S><V><F><N><P><I><V><Y><C><W><R><I><K><K><F><R><E><A><C><I><E><L><L><P><Q><T><F><Q><I><L><P><K><V><P><E><R><I><R><R><R><I><Q><P><S><T><V><Y><V><C><N><E><N><Q><S><A><V>	Orphan receptor. May play a role in brain function.<BOP>	Q9Y5Y3
P13727	PRG2_HUMAN	Pregnancy-associated major basic protein	Homo	<M><K><L><P><L><L><L><A><L><L><F><G><A><V><S><A><L><H><L><R><S><E><T><S><T><F><E><T><P><L><G><A><K><T><L><P><E><D><E><E><T><P><E><Q><E><M><E><E><T><P><C><R><E><L><E><E><E><E><E><W><G><S><G><S><E><D><A><S><K><K><D><G><A><V><E><S><I><S><V><P><D><M><V><D><K><N><L><T><C><P><E><E><E><D><T><V><K><V><V><G><I><P><G><C><Q><T><C><R><Y><L><L><V><R><S><L><Q><T><F><S><Q><A><W><F><T><C><R><R><C><Y><R><G><N><L><V><S><I><H><N><F><N><I><N><Y><R><I><Q><C><S><V><S><A><L><N><Q><G><Q><V><W><I><G><G><R><I><T><G><S><G><R><C><R><R><F><Q><W><V><D><G><S><R><W><N><F><A><Y><W><A><A><H><Q><P><W><S><R><G><G><H><C><V><A><L><C><T><R><G><G><H><W><R><R><A><H><C><L><R><R><L><P><F><I><C><S><Y>	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.<BOP>	P13727
P08236	BGLR_HUMAN	Beta-G1	Homo	<M><A><R><G><S><A><V><A><W><A><A><L><G><P><L><L><W><G><C><A><L><G><L><Q><G><G><M><L><Y><P><Q><E><S><P><S><R><E><C><K><E><L><D><G><L><W><S><F><R><A><D><F><S><D><N><R><R><R><G><F><E><E><Q><W><Y><R><R><P><L><W><E><S><G><P><T><V><D><M><P><V><P><S><S><F><N><D><I><S><Q><D><W><R><L><R><H><F><V><G><W><V><W><Y><E><R><E><V><I><L><P><E><R><W><T><Q><D><L><R><T><R><V><V><L><R><I><G><S><A><H><S><Y><A><I><V><W><V><N><G><V><D><T><L><E><H><E><G><G><Y><L><P><F><E><A><D><I><S><N><L><V><Q><V><G><P><L><P><S><R><L><R><I><T><I><A><I><N><N><T><L><T><P><T><T><L><P><P><G><T><I><Q><Y><L><T><D><T><S><K><Y><P><K><G><Y><F><V><Q><N><T><Y><F><D><F><F><N><Y><A><G><L><Q><R><S><V><L><L><Y><T><T><P><T><T><Y><I><D><D><I><T><V><T><T><S><V><E><Q><D><S><G><L><V><N><Y><Q><I><S><V><K><G><S><N><L><F><K><L><E><V><R><L><L><D><A><E><N><K><V><V><A><N><G><T><G><T><Q><G><Q><L><K><V><P><G><V><S><L><W><W><P><Y><L><M><H><E><R><P><A><Y><L><Y><S><L><E><V><Q><L><T><A><Q><T><S><L><G><P><V><S><D><F><Y><T><L><P><V><G><I><R><T><V><A><V><T><K><S><Q><F><L><I><N><G><K><P><F><Y><F><H><G><V><N><K><H><E><D><A><D><I><R><G><K><G><F><D><W><P><L><L><V><K><D><F><N><L><L><R><W><L><G><A><N><A><F><R><T><S><H><Y><P><Y><A><E><E><V><M><Q><M><C><D><R><Y><G><I><V><V><I><D><E><C><P><G><V><G><L><A><L><P><Q><F><F><N><N><V><S><L><H><H><H><M><Q><V><M><E><E><V><V><R><R><D><K><N><H><P><A><V><V><M><W><S><V><A><N><E><P><A><S><H><L><E><S><A><G><Y><Y><L><K><M><V><I><A><H><T><K><S><L><D><P><S><R><P><V><T><F><V><S><N><S><N><Y><A><A><D><K><G><A><P><Y><V><D><V><I><C><L><N><S><Y><Y><S><W><Y><H><D><Y><G><H><L><E><L><I><Q><L><Q><L><A><T><Q><F><E><N><W><Y><K><K><Y><Q><K><P><I><I><Q><S><E><Y><G><A><E><T><I><A><G><F><H><Q><D><P><P><L><M><F><T><E><E><Y><Q><K><S><L><L><E><Q><Y><H><L><G><L><D><Q><K><R><R><K><Y><V><V><G><E><L><I><W><N><F><A><D><F><M><T><E><Q><S><P><T><R><V><L><G><N><K><K><G><I><F><T><R><Q><R><Q><P><K><S><A><A><F><L><L><R><E><R><Y><W><K><I><A><N><E><T><R><Y><P><H><S><V><A><K><S><Q><C><L><E><N><S><L><F><T>	Plays an important role in the degradation of dermatan and keratan sulfates.<BOP>	P08236
Q9NSB8	HOME2_HUMAN	Cupidin	Homo	<M><G><E><Q><P><I><F><T><T><R><A><H><V><F><Q><I><D><P><N><T><K><K><N><W><M><P><A><S><K><Q><A><V><T><V><S><Y><F><Y><D><V><T><R><N><S><Y><R><I><I><S><V><D><G><A><K><V><I><I><N><S><T><I><T><P><N><M><T><F><T><K><T><S><Q><K><F><G><Q><W><A><D><S><R><A><N><T><V><F><G><L><G><F><S><S><E><Q><Q><L><T><K><F><A><E><K><F><Q><E><V><K><E><A><A><K><I><A><K><D><K><T><Q><E><K><I><E><T><S><S><N><H><S><Q><E><S><G><R><E><T><P><S><S><T><Q><A><S><S><V><N><G><T><D><D><E><K><A><S><H><A><G><P><A><N><T><H><L><K><S><E><N><D><K><L><K><I><A><L><T><Q><S><A><A><N><V><K><K><W><E><I><E><L><Q><T><L><R><E><S><N><A><R><L><T><T><A><L><Q><E><S><A><A><S><V><E><Q><W><K><R><Q><F><S><I><C><R><D><E><N><D><R><L><R><N><K><I><D><E><L><E><E><Q><C><S><E><I><N><R><E><K><E><K><N><T><Q><L><K><R><R><I><E><E><L><E><A><E><L><R><E><K><E><T><E><L><K><D><L><R><K><Q><S><E><I><I><P><Q><L><M><S><E><C><E><Y><V><S><E><K><L><E><A><A><E><R><D><N><Q><N><L><E><D><K><V><R><S><L><K><T><D><I><E><E><S><K><Y><R><Q><R><H><L><K><V><E><L><K><S><F><L><E><V><L><D><G><K><I><D><D><L><H><D><F><R><R><G><L><S><K><L><G><T><D><N>	Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses . Required for normal hearing . Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA .<BOP>	Q9NSB8
Q9H078	CLPB_HUMAN	Suppressor of potassium transport defect 3	Homo	<M><L><G><S><L><V><L><R><R><K><A><L><A><P><R><L><L><L><R><L><L><R><S><P><T><L><R><G><H><G><G><A><S><G><R><N><V><T><T><G><S><L><G><E><P><Q><W><L><R><V><A><T><G><G><R><P><G><T><S><P><A><L><F><S><G><R><G><A><A><T><G><G><R><Q><G><G><R><F><D><T><K><C><L><A><A><A><T><W><G><R><L><P><G><P><E><E><T><L><P><G><Q><D><S><W><N><G><V><P><S><R><A><G><L><G><M><C><A><L><A><A><A><L><V><V><H><C><Y><S><K><S><P><S><N><K><D><A><A><L><L><E><A><A><R><A><N><N><M><Q><E><V><S><R><L><L><S><E><G><A><D><V><N><A><K><H><R><L><G><W><T><A><L><M><V><A><A><I><N><R><N><N><S><V><V><Q><V><L><L><A><A><G><A><D><P><N><L><G><D><D><F><S><S><V><Y><K><T><A><K><E><Q><G><I><H><S><L><E><D><G><G><Q><D><G><A><S><R><H><I><T><N><Q><W><T><S><A><L><E><F><R><R><W><L><G><L><P><A><G><V><L><I><T><R><E><D><D><F><N><N><R><L><N><N><R><A><S><F><K><G><C><T><A><L><H><Y><A><V><L><A><D><D><Y><R><T><V><K><E><L><L><D><G><G><A><N><P><L><Q><R><N><E><M><G><H><T><P><L><D><Y><A><R><E><G><E><V><M><K><L><L><R><T><S><E><A><K><Y><Q><E><K><Q><R><K><R><E><A><E><E><R><R><R><F><P><L><E><Q><R><L><K><E><H><I><I><G><Q><E><S><A><I><A><T><V><G><A><A><I><R><R><K><E><N><G><W><Y><D><E><E><H><P><L><V><F><L><F><L><G><S><S><G><I><G><K><T><E><L><A><K><Q><T><A><K><Y><M><H><K><D><A><K><K><G><F><I><R><L><D><M><S><E><F><Q><E><R><H><E><V><A><K><F><I><G><S><P><P><G><Y><V><G><H><E><E><G><G><Q><L><T><K><K><L><K><Q><C><P><N><A><V><V><L><F><D><E><V><D><K><A><H><P><D><V><L><T><I><M><L><Q><L><F><D><E><G><R><L><T><D><G><K><G><K><T><I><D><C><K><D><A><I><F><I><M><T><S><N><V><A><S><D><E><I><A><Q><H><A><L><Q><L><R><Q><E><A><L><E><M><S><R><N><R><I><A><E><N><L><G><D><V><Q><I><S><D><K><I><T><I><S><K><N><F><K><E><N><V><I><R><P><I><L><K><A><H><F><R><R><D><E><F><L><G><R><I><N><E><I><V><Y><F><L><P><F><C><H><S><E><L><I><Q><L><V><N><K><E><L><N><F><W><A><K><R><A><K><Q><R><H><N><I><T><L><L><W><D><R><E><V><A><D><V><L><V><D><G><Y><N><V><H><Y><G><A><R><S><I><K><H><E><V><E><R><R><V><V><N><Q><L><A><A><A><Y><E><Q><D><L><L><P><G><G><C><T><L><R><I><T><V><E><D><S><D><K><Q><L><L><K><S><P><E><L><P><S><P><Q><A><E><K><R><L><P><K><L><R><L><E><I><I><D><K><D><S><K><T><R><R><L><D><I><R><A><P><L><H><P><E><K><V><C><N><T><I>	May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 .<BOP>	Q9H078
Q8NBI5	S43A3_HUMAN	Solute carrier family 43 member 3	Homo	<M><A><G><Q><G><L><P><L><H><V><A><T><L><L><T><G><L><L><E><C><L><G><F><A><G><V><L><F><G><W><P><S><L><V><F><V><F><K><N><E><D><Y><F><K><D><L><C><G><P><D><A><G><P><I><G><N><A><T><G><Q><A><D><C><K><A><Q><D><E><R><F><S><L><I><F><T><L><G><S><F><M><N><N><F><M><T><F><P><T><G><Y><I><F><D><R><F><K><T><T><V><A><R><L><I><A><I><F><F><Y><T><T><A><T><L><I><I><A><F><T><S><A><G><S><A><V><L><L><F><L><A><M><P><M><L><T><I><G><G><I><L><F><L><I><T><N><L><Q><I><G><N><L><F><G><Q><H><R><S><T><I><I><T><L><Y><N><G><A><F><D><S><S><S><A><V><F><L><I><I><K><L><L><Y><E><K><G><I><S><L><R><A><S><F><I><F><I><S><V><C><S><T><W><H><V><A><R><T><F><L><L><M><P><R><G><H><I><P><Y><P><L><P><P><N><Y><S><Y><G><L><C><P><G><N><G><T><T><K><E><E><K><E><T><A><E><H><E><N><R><E><L><Q><S><K><E><F><L><S><A><K><E><E><T><P><G><A><G><Q><K><Q><E><L><R><S><F><W><S><Y><A><F><S><R><R><F><A><W><H><L><V><W><L><S><V><I><Q><L><W><H><Y><L><F><I><G><T><L><N><S><L><L><T><N><M><A><G><G><D><M><A><R><V><S><T><Y><T><N><A><F><A><F><T><Q><F><G><V><L><C><A><P><W><N><G><L><L><M><D><R><L><K><Q><K><Y><Q><K><E><A><R><K><T><G><S><S><T><L><A><V><A><L><C><S><T><V><P><S><L><A><L><T><S><L><L><C><L><G><F><A><L><C><A><S><V><P><I><L><P><L><Q><Y><L><T><F><I><L><Q><V><I><S><R><S><F><L><Y><G><S><N><A><A><F><L><T><L><A><F><P><S><E><H><F><G><K><L><F><G><L><V><M><A><L><S><A><V><V><S><L><L><Q><F><P><I><F><T><L><I><K><G><S><L><Q><N><D><P><F><Y><V><N><V><M><F><M><L><A><I><L><L><T><F><F><H><P><F><L><V><Y><R><E><C><R><T><W><K><E><S><P><S><A><I><A>	Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobase adenine . Mediates the influx and efflux of the purine nucleobase analog drug 6-mercaptopurine across the membrane .<BOP>	Q8NBI5
P07305	H10_HUMAN	Histone H1.0, N-terminally processed	Homo	<M><T><E><N><S><T><S><A><P><A><A><K><P><K><R><A><K><A><S><K><K><S><T><D><H><P><K><Y><S><D><M><I><V><A><A><I><Q><A><E><K><N><R><A><G><S><S><R><Q><S><I><Q><K><Y><I><K><S><H><Y><K><V><G><E><N><A><D><S><Q><I><K><L><S><I><K><R><L><V><T><T><G><V><L><K><Q><T><K><G><V><G><A><S><G><S><F><R><L><A><K><S><D><E><P><K><K><S><V><A><F><K><K><T><K><K><E><I><K><K><V><A><T><P><K><K><A><S><K><P><K><K><A><A><S><K><A><P><T><K><K><P><K><A><T><P><V><K><K><A><K><K><K><L><A><A><T><P><K><K><A><K><K><P><K><T><V><K><A><K><P><V><K><A><S><K><P><K><K><A><K><P><V><K><P><K><A><K><S><S><A><K><R><A><G><K><K><K>	Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.<BOP>	P07305
Q7Z6J8	UBE3D_HUMAN	Ubiquitin-conjugating enzyme E2C-binding protein	Homo	<M><A><A><S><A><A><E><T><R><V><F><L><E><V><R><G><Q><L><Q><S><A><L><L><I><L><G><E><P><K><E><G><G><M><P><M><N><I><S><I><M><P><S><S><L><Q><M><K><T><P><E><G><C><T><E><I><Q><L><P><A><E><V><R><L><V><P><S><S><C><R><G><L><Q><F><V><V><G><D><G><L><H><L><R><L><Q><T><Q><A><K><L><G><T><K><L><I><S><M><F><N><Q><S><S><Q><T><Q><E><C><C><T><F><Y><C><Q><S><C><G><E><V><I><I><K><D><R><K><L><L><R><V><L><P><L><P><S><E><N><W><G><A><L><V><G><E><W><C><C><H><P><D><P><F><A><N><K><S><L><H><P><Q><E><N><D><C><F><I><G><D><S><F><F><L><V><N><L><R><T><S><L><W><Q><Q><R><P><E><L><S><P><V><E><M><C><C><V><S><S><D><N><H><C><K><L><E><P><K><A><N><T><K><V><I><C><K><R><C><K><V><M><L><G><E><T><V><S><S><E><T><T><K><F><Y><M><T><E><I><I><I><Q><S><S><E><R><S><F><P><I><I><P><R><S><W><F><V><Q><S><V><I><A><Q><C><L><V><Q><L><S><S><A><R><S><T><F><R><F><T><I><Q><G><Q><D><D><K><V><Y><I><L><L><W><L><L><N><S><D><S><L><V><I><E><S><L><R><N><S><K><Y><I><K><K><F><P><L><L><E><N><T><F><K><A><D><S><S><S><A><W><S><A><V><K><V><L><Y><Q><P><C><I><K><S><R><N><E><K><L><V><S><L><W><E><S><D><I><S><V><H><P><L><T><L><P><S><A><T><C><L><E><L><L><L><I><L><S><K><S><N><A><N><L><P><S><S><L><R><R><V><N><S><F><Q><V><A><F><L><K><M>	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.<BOP>	Q7Z6J8
P35612	ADDB_HUMAN	Erythrocyte adducin subunit beta	Homo	<M><S><E><E><T><V><P><E><A><A><S><P><P><P><P><Q><G><Q><P><Y><F><D><R><F><S><E><D><D><P><E><Y><M><R><L><R><N><R><A><A><D><L><R><Q><D><F><N><L><M><E><Q><K><K><R><V><T><M><I><L><Q><S><P><S><F><R><E><E><L><E><G><L><I><Q><E><Q><M><K><K><G><N><N><S><S><N><I><W><A><L><R><Q><I><A><D><F><M><A><S><T><S><H><A><V><F><P><T><S><S><M><N><V><S><M><M><T><P><I><N><D><L><H><T><A><D><S><L><N><L><A><K><G><E><R><L><M><R><C><K><I><S><S><V><Y><R><L><L><D><L><Y><G><W><A><Q><L><S><D><T><Y><V><T><L><R><V><S><K><E><Q><D><H><F><L><I><S><P><K><G><V><S><C><S><E><V><T><A><S><S><L><I><K><V><N><I><L><G><E><V><V><E><K><G><S><S><C><F><P><V><D><T><T><G><F><C><L><H><S><A><I><Y><A><A><R><P><D><V><R><C><I><I><H><L><H><T><P><A><T><A><A><V><S><A><M><K><W><G><L><L><P><V><S><H><N><A><L><L><V><G><D><M><A><Y><Y><D><F><N><G><E><M><E><Q><E><A><D><R><I><N><L><Q><K><C><L><G><P><T><C><K><I><L><V><L><R><N><H><G><V><V><A><L><G><D><T><V><E><E><A><F><Y><K><I><F><H><L><Q><A><A><C><E><I><Q><V><S><A><L><S><S><A><G><G><V><E><N><L><I><L><L><E><Q><E><K><H><R><P><H><E><V><G><S><V><Q><W><A><G><S><T><F><G><P><M><Q><K><S><R><L><G><E><H><E><F><E><A><L><M><R><M><L><D><N><L><G><Y><R><T><G><Y><T><Y><R><H><P><F><V><Q><E><K><T><K><H><K><S><E><V><E><I><P><A><T><V><T><A><F><V><F><E><E><D><G><A><P><V><P><A><L><R><Q><H><A><Q><K><Q><Q><K><E><K><T><R><W><L><N><T><P><N><T><Y><L><R><V><N><V><A><D><E><V><Q><R><S><M><G><S><P><R><P><K><T><T><W><M><K><A><D><E><V><E><K><S><S><S><G><M><P><I><R><I><E><N><P><N><Q><F><V><P><L><Y><T><D><P><Q><E><V><L><E><M><R><N><K><I><R><E><Q><N><R><Q><D><V><K><S><A><G><P><Q><S><Q><L><L><A><S><V><I><A><E><K><S><R><S><P><S><T><E><S><Q><L><M><S><K><G><D><E><D><T><K><D><D><S><E><E><T><V><P><N><P><F><S><Q><L><T><D><Q><E><L><E><E><Y><K><K><E><V><E><R><K><K><L><E><L><D><G><E><K><E><T><A><P><E><E><P><G><S><P><A><K><S><A><P><A><S><P><V><Q><S><P><A><K><E><A><E><T><K><S><P><L><V><S><P><S><K><S><L><E><E><G><T><K><K><T><E><T><S><K><A><A><T><T><E><P><E><T><T><Q><P><E><G><V><V><V><N><G><R><E><E><E><Q><T><A><E><E><I><L><S><K><G><L><S><Q><M><T><T><S><A><D><T><D><V><D><T><S><K><D><K><T><E><S><V><T><S><G><P><M><S><P><E><G><S><P><S><K><S><P><S><K><K><K><K><K><F><R><T><P><S><F><L><K><K><S><K><K><K><E><K><V><E><S>	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.<BOP>	P35612
P22914	CRYGS_HUMAN	Gamma-S-crystallin	Homo	<M><S><K><T><G><T><K><I><T><F><Y><E><D><K><N><F><Q><G><R><R><Y><D><C><D><C><D><C><A><D><F><H><T><Y><L><S><R><C><N><S><I><K><V><E><G><G><T><W><A><V><Y><E><R><P><N><F><A><G><Y><M><Y><I><L><P><Q><G><E><Y><P><E><Y><Q><R><W><M><G><L><N><D><R><L><S><S><C><R><A><V><H><L><P><S><G><G><Q><Y><K><I><Q><I><F><E><K><G><D><F><S><G><Q><M><Y><E><T><T><E><D><C><P><S><I><M><E><Q><F><H><M><R><E><I><H><S><C><K><V><L><E><G><V><W><I><F><Y><E><L><P><N><Y><R><G><R><Q><Y><L><L><D><K><K><E><Y><R><K><P><I><D><W><G><A><A><S><P><A><V><Q><S><F><R><R><I><V><E>	Crystallins are the dominant structural components of the vertebrate eye lens.<BOP>	P22914
Q49AA0	ZFP69_HUMAN	Zinc finger protein 642	Homo	<M><P><Q><Q><L><L><I><T><L><P><T><E><A><S><T><W><V><K><L><Q><H><P><K><K><A><V><E><G><A><P><L><W><E><D><V><T><K><M><F><E><G><E><A><L><L><S><Q><D><A><E><D><V><K><T><Q><R><E><S><L><E><D><E><V><T><P><G><L><P><T><A><E><S><Q><E><L><L><T><F><K><D><I><S><I><D><F><T><Q><E><E><W><G><Q><L><A><P><A><H><Q><N><L><Y><R><E><V><M><L><E><N><Y><S><N><L><V><S><V><G><Y><Q><L><S><K><P><S><V><I><S><Q><L><E><K><G><E><E><P><W><M><A><E><K><E><G><P><G><D><P><S><S><D><L><K><S><K><I><E><T><I><E><S><T><A><K><S><T><I><S><Q><E><R><L><Y><H><G><I><M><M><E><S><F><M><R><D><D><I><I><Y><S><T><L><R><K><V><S><T><Y><D><D><V><L><E><R><H><Q><E><T><C><M><R><D><V><R><Q><A><I><L><T><H><K><K><R><V><Q><E><T><N><K><F><G><E><N><I><I><V><H><S><N><V><I><I><E><Q><R><H><H><K><Y><D><T><P><T><K><R><N><T><Y><K><L><D><L><I><N><H><P><T><S><Y><I><R><T><K><T><Y><E><C><N><I><C><E><K><I><F><K><Q><P><I><H><L><T><E><H><M><R><I><H><T><G><E><K><P><F><R><C><K><E><C><G><R><A><F><S><Q><S><A><S><L><S><T><H><Q><R><I><H><T><G><E><K><P><F><E><C><E><E><C><G><K><A><F><R><H><R><S><S><L><N><Q><H><H><R><T><H><T><G><E><K><P><Y><V><C><D><K><C><Q><K><A><F><S><Q><N><I><S><L><V><Q><H><L><R><T><H><S><G><E><K><P><F><T><C><N><E><C><G><K><T><F><R><Q><I><R><H><L><S><E><H><I><R><I><H><T><G><E><K><P><Y><A><C><T><A><C><C><K><T><F><S><H><R><A><Y><L><T><H><H><Q><R><I><H><T><G><E><R><P><Y><K><C><K><E><C><G><K><A><F><R><Q><R><I><H><L><S><N><H><K><T><V><H><T><G><V><K><A><Y><E><C><N><R><C><G><K><A><Y><R><H><D><S><S><F><K><K><H><Q><R><H><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Y><N><S><S><L><S><R><H><H><E><I><H><R><R><N><A><F><R><N><K><V>	Putative transcription factor that appears to regulate lipid metabolism.<BOP>	Q49AA0
P12004	PCNA_HUMAN	Cyclin	Homo	<M><F><E><A><R><L><V><Q><G><S><I><L><K><K><V><L><E><A><L><K><D><L><I><N><E><A><C><W><D><I><S><S><S><G><V><N><L><Q><S><M><D><S><S><H><V><S><L><V><Q><L><T><L><R><S><E><G><F><D><T><Y><R><C><D><R><N><L><A><M><G><V><N><L><T><S><M><S><K><I><L><K><C><A><G><N><E><D><I><I><T><L><R><A><E><D><N><A><D><T><L><A><L><V><F><E><A><P><N><Q><E><K><V><S><D><Y><E><M><K><L><M><D><L><D><V><E><Q><L><G><I><P><E><Q><E><Y><S><C><V><V><K><M><P><S><G><E><F><A><R><I><C><R><D><L><S><H><I><G><D><A><V><V><I><S><C><A><K><D><G><V><K><F><S><A><S><G><E><L><G><N><G><N><I><K><L><S><Q><T><S><N><V><D><K><E><E><E><A><V><T><I><E><M><N><E><P><V><Q><L><T><F><A><L><R><Y><L><N><F><F><T><K><A><T><P><L><S><S><T><V><T><L><S><M><S><A><D><V><P><L><V><V><E><Y><K><I><A><D><M><G><H><L><K><Y><Y><L><A><P><K><I><E><D><E><E><G><S>	Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand . Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways . Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion .<BOP>	P12004
Q9NX14	NDUBB_HUMAN	Neuronal protein 17.3	Homo	<M><A><A><G><L><F><G><L><S><A><R><R><L><L><A><A><A><A><T><R><G><L><P><A><A><R><V><R><W><E><S><S><F><S><R><T><V><V><A><P><S><A><V><A><G><K><R><P><P><E><P><T><T><P><W><Q><E><D><P><E><P><E><D><E><N><L><Y><E><K><N><P><D><S><H><G><Y><D><K><D><P><V><L><D><V><W><N><M><R><L><V><F><F><F><G><V><S><I><I><L><V><L><G><S><T><F><V><A><Y><L><P><D><Y><R><M><K><E><W><S><R><R><E><A><E><R><L><V><K><Y><R><E><A><N><G><L><P><I><M><E><S><N><C><F><D><P><S><K><I><Q><L><P><E><D><E>	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP>	Q9NX14
Q15485	FCN2_HUMAN	Serum lectin p35	Homo	<M><E><L><D><R><A><V><G><V><L><G><A><A><T><L><L><L><S><F><L><G><M><A><W><A><L><Q><A><A><D><T><C><P><E><V><K><M><V><G><L><E><G><S><D><K><L><T><I><L><R><G><C><P><G><L><P><G><A><P><G><P><K><G><E><A><G><T><N><G><K><R><G><E><R><G><P><P><G><P><P><G><K><A><G><P><P><G><P><N><G><A><P><G><E><P><Q><P><C><L><T><G><P><R><T><C><K><D><L><L><D><R><G><H><F><L><S><G><W><H><T><I><Y><L><P><D><C><R><P><L><T><V><L><C><D><M><D><T><D><G><G><G><W><T><V><F><Q><R><R><V><D><G><S><V><D><F><Y><R><D><W><A><T><Y><K><Q><G><F><G><S><R><L><G><E><F><W><L><G><N><D><N><I><H><A><L><T><A><Q><G><T><S><E><L><R><V><D><L><V><D><F><E><D><N><Y><Q><F><A><K><Y><R><S><F><K><V><A><D><E><A><E><K><Y><N><L><V><L><G><A><F><V><E><G><S><A><G><D><S><L><T><F><H><N><N><Q><S><F><S><T><K><D><Q><D><N><D><L><N><T><G><N><C><A><V><M><F><Q><G><A><W><W><Y><K><N><C><H><V><S><N><L><N><G><R><Y><L><R><G><T><H><G><S><F><A><N><G><I><N><W><K><S><G><K><G><Y><N><Y><S><Y><K><V><S><E><M><K><V><R><P><A>	May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.<BOP>	Q15485
Q8NGC8	O11H7_HUMAN	Olfactory receptor OR14-32	Homo	<M><N><N><S><Q><I><S><T><V><T><Q><F><V><L><L><G><F><P><G><P><W><K><I><Q><I><I><F><F><S><M><I><L><L><V><Y><I><F><T><L><T><G><N><M><A><I><I><C><A><V><R><W><D><H><R><L><H><T><P><M><Y><V><L><L><A><N><F><S><F><L><E><I><W><Y><V><T><C><T><V><P><N><M><L><V><N><F><F><S><K><T><K><T><I><S><F><S><G><C><F><T><Q><F><H><F><F><F><S><L><G><T><T><E><C><F><F><L><C><V><M><A><Y><D><R><Y><L><A><I><C><H><P><L><H><Y><P><S><I><M><T><G><Q><L><C><G><I><L><V><S><L><C><W><L><I><G><F><L><G><H><S><I><S><I><F><F><I><F><Q><L><P><F><C><G><P><N><I><I><D><H><F><L><C><D><V><D><P><L><M><A><L><S><S><A><P><T><H><I><I><G><H><V><F><H><S><V><S><S><L><F><I><N><L><T><M><V><Y><I><L><G><S><Y><T><L><V><L><R><T><V><L><Q><V><P><S><S><A><G><W><Q><K><A><I><S><T><C><G><S><H><L><V><V><V><S><L><F><Y><G><A><I><M><L><M><Y><V><S><P><T><P><G><N><S><V><A><M><H><K><L><I><T><L><I><Y><S><V><V><T><P><V><L><N><P><L><I><Y><S><L><R><N><K><D><M><K><Y><A><L><H><H><V><F><C><G><M><R><I><I><Q><R><S>	Odorant receptor. Activated by isovaleric acid.<BOP>	Q8NGC8
P41212	ETV6_HUMAN	ETS-related protein Tel1	Homo	<M><S><E><T><P><A><Q><C><S><I><K><Q><E><R><I><S><Y><T><P><P><E><S><P><V><P><S><Y><A><S><S><T><P><L><H><V><P><V><P><R><A><L><R><M><E><E><D><S><I><R><L><P><A><H><L><R><L><Q><P><I><Y><W><S><R><D><D><V><A><Q><W><L><K><W><A><E><N><E><F><S><L><R><P><I><D><S><N><T><F><E><M><N><G><K><A><L><L><L><L><T><K><E><D><F><R><Y><R><S><P><H><S><G><D><V><L><Y><E><L><L><Q><H><I><L><K><Q><R><K><P><R><I><L><F><S><P><F><F><H><P><G><N><S><I><H><T><Q><P><E><V><I><L><H><Q><N><H><E><E><D><N><C><V><Q><R><T><P><R><P><S><V><D><N><V><H><H><N><P><P><T><I><E><L><L><H><R><S><R><S><P><I><T><T><N><H><R><P><S><P><D><P><E><Q><R><P><L><R><S><P><L><D><N><M><I><R><R><L><S><P><A><E><R><A><Q><G><P><R><P><H><Q><E><N><N><H><Q><E><S><Y><P><L><S><V><S><P><M><E><N><N><H><C><P><A><S><S><E><S><H><P><K><P><S><S><P><R><Q><E><S><T><R><V><I><Q><L><M><P><S><P><I><M><H><P><L><I><L><N><P><R><H><S><V><D><F><K><Q><S><R><L><S><E><D><G><L><H><R><E><G><K><P><I><N><L><S><H><R><E><D><L><A><Y><M><N><H><I><M><V><S><V><S><P><P><E><E><H><A><M><P><I><G><R><I><A><D><C><R><L><L><W><D><Y><V><Y><Q><L><L><S><D><S><R><Y><E><N><F><I><R><W><E><D><K><E><S><K><I><F><R><I><V><D><P><N><G><L><A><R><L><W><G><N><H><K><N><R><T><N><M><T><Y><E><K><M><S><R><A><L><R><H><Y><Y><K><L><N><I><I><R><K><E><P><G><Q><R><L><L><F><R><F><M><K><T><P><D><E><I><M><S><G><R><T><D><R><L><E><H><L><E><S><Q><E><L><D><E><Q><I><Y><Q><E><D><E><C>	Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.<BOP>	P41212
Q9H7B2	RPF2_HUMAN	Ribosome biogenesis protein RPF2 homolog	Homo	<M><D><T><L><D><R><V><V><K><P><K><T><K><R><A><K><R><F><L><E><K><R><E><P><K><L><N><E><N><I><K><N><A><M><L><I><K><G><G><N><A><N><A><T><V><T><K><V><L><K><D><V><Y><A><L><K><K><P><Y><G><V><L><Y><K><K><K><N><I><T><R><P><F><E><D><Q><T><S><L><E><F><F><S><K><K><S><D><C><S><L><F><M><F><G><S><H><N><K><K><R><P><N><N><L><V><I><G><R><M><Y><D><Y><H><V><L><D><M><I><E><L><G><I><E><N><F><V><S><L><K><D><I><K><N><S><K><C><P><E><G><T><K><P><M><L><I><F><A><G><D><D><F><D><V><T><E><D><Y><R><R><L><K><S><L><L><I><D><F><F><R><G><P><T><V><S><N><I><R><L><A><G><L><E><Y><V><L><H><F><T><A><L><N><G><K><I><Y><F><R><S><Y><K><L><L><L><K><K><S><G><C><R><T><P><R><I><E><L><E><E><M><G><P><S><L><D><L><V><L><R><R><T><H><L><A><S><D><D><L><Y><K><L><S><M><K><M><P><K><A><L><K><P><K><K><K><K><N><I><S><H><D><T><F><G><T><T><Y><G><R><I><H><M><Q><K><Q><D><L><S><K><L><Q><T><R><K><M><K><G><L><K><K><R><P><A><E><R><I><T><E><D><H><E><K><K><S><K><R><I><K><K><N>	Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.<BOP>	Q9H7B2
P0DOY3	IGLC3_HUMAN	Ig lambda-3 chain C regions	Homo	<G><Q><P><K><A><A><P><S><V><T><L><F><P><P><S><S><E><E><L><Q><A><N><K><A><T><L><V><C><L><I><S><D><F><Y><P><G><A><V><T><V><A><W><K><A><D><S><S><P><V><K><A><G><V><E><T><T><T><P><S><K><Q><S><N><N><K><Y><A><A><S><S><Y><L><S><L><T><P><E><Q><W><K><S><H><K><S><Y><S><C><Q><V><T><H><E><G><S><T><V><E><K><T><V><A><P><T><E><C><S>	Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>	P0DOY3
P03915	NU5M_HUMAN	NADH dehydrogenase subunit 5	Homo	<M><T><M><H><T><T><M><T><T><L><T><L><T><S><L><I><P><P><I><L><T><T><L><V><N><P><N><K><K><N><S><Y><P><H><Y><V><K><S><I><V><A><S><T><F><I><I><S><L><F><P><T><T><M><F><M><C><L><D><Q><E><V><I><I><S><N><W><H><W><A><T><T><Q><T><T><Q><L><S><L><S><F><K><L><D><Y><F><S><M><M><F><I><P><V><A><L><F><V><T><W><S><I><M><E><F><S><L><W><Y><M><N><S><D><P><N><I><N><Q><F><F><K><Y><L><L><I><F><L><I><T><M><L><I><L><V><T><A><N><N><L><F><Q><L><F><I><G><W><E><G><V><G><I><M><S><F><L><L><I><S><W><W><Y><A><R><A><D><A><N><T><A><A><I><Q><A><I><L><Y><N><R><I><G><D><I><G><F><I><L><A><L><A><W><F><I><L><H><S><N><S><W><D><P><Q><Q><M><A><L><L><N><A><N><P><S><L><T><P><L><L><G><L><L><L><A><A><A><G><K><S><A><Q><L><G><L><H><P><W><L><P><S><A><M><E><G><P><T><P><V><S><A><L><L><H><S><S><T><M><V><V><A><G><I><F><L><L><I><R><F><H><P><L><A><E><N><S><P><L><I><Q><T><L><T><L><C><L><G><A><I><T><T><L><F><A><A><V><C><A><L><T><Q><N><D><I><K><K><I><V><A><F><S><T><S><S><Q><L><G><L><M><M><V><T><I><G><I><N><Q><P><H><L><A><F><L><H><I><C><T><H><A><F><F><K><A><M><L><F><M><C><S><G><S><I><I><H><N><L><N><N><E><Q><D><I><R><K><M><G><G><L><L><K><T><M><P><L><T><S><T><S><L><T><I><G><S><L><A><L><A><G><M><P><F><L><T><G><F><Y><S><K><D><H><I><I><E><T><A><N><M><S><Y><T><N><A><W><A><L><S><I><T><L><I><A><T><S><L><T><S><A><Y><S><T><R><M><I><L><L><T><L><T><G><Q><P><R><F><P><T><L><T><N><I><N><E><N><N><P><T><L><L><N><P><I><K><R><L><A><A><G><S><L><F><A><G><F><L><I><T><N><N><I><S><P><A><S><P><F><Q><T><T><I><P><L><Y><L><K><L><T><A><L><A><V><T><F><L><G><L><L><T><A><L><D><L><N><Y><L><T><N><K><L><K><M><K><S><P><L><C><T><F><Y><F><S><N><M><L><G><F><Y><P><S><I><T><H><R><T><I><P><Y><L><G><L><L><T><S><Q><N><L><P><L><L><L><L><D><L><T><W><L><E><K><L><L><P><K><T><I><S><Q><H><Q><I><S><T><S><I><I><T><S><T><Q><K><G><M><I><K><L><Y><F><L><S><F><F><F><P><L><I><L><T><L><L><L><I><T>	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP>	P03915
Q8NH21	OR4F5_HUMAN	Olfactory receptor 4F5	Homo	<M><V><T><E><F><I><F><L><G><L><S><D><S><Q><E><L><Q><T><F><L><F><M><L><F><F><V><F><Y><G><G><I><V><F><G><N><L><L><I><V><I><T><V><V><S><D><S><H><L><H><S><P><M><Y><F><L><L><A><N><L><S><L><I><D><L><S><L><S><S><V><T><A><P><K><M><I><T><D><F><F><S><Q><R><K><V><I><S><F><K><G><C><L><V><Q><I><F><L><L><H><F><F><G><G><S><E><M><V><I><L><I><A><M><G><F><D><R><Y><I><A><I><C><K><P><L><H><Y><T><T><I><M><C><G><N><A><C><V><G><I><M><A><V><T><W><G><I><G><F><L><H><S><V><S><Q><L><A><F><A><V><H><L><L><F><C><G><P><N><E><V><D><S><F><Y><C><D><L><P><R><V><I><K><L><A><C><T><D><T><Y><R><L><D><I><M><V><I><A><N><S><G><V><L><T><V><C><S><F><V><L><L><I><I><S><Y><T><I><I><L><M><T><I><Q><H><R><P><L><D><K><S><S><K><A><L><S><T><L><T><A><H><I><T><V><V><L><L><F><F><G><P><C><V><F><I><Y><A><W><P><F><P><I><K><S><L><D><K><F><L><A><V><F><Y><S><V><I><T><P><L><L><N><P><I><I><Y><T><L><R><N><K><D><M><K><T><A><I><R><Q><L><R><K><W><D><A><H><S><S><V><K><F>	Odorant receptor.<BOP>	Q8NH21
Q99909	SSX3_HUMAN	Cancer/testis antigen 5.3	Homo	<M><N><G><D><D><T><F><A><R><R><P><T><V><G><A><Q><I><P><E><K><I><Q><K><A><F><D><D><I><A><K><Y><F><S><K><E><E><W><E><K><M><K><V><S><E><K><I><V><Y><V><Y><M><K><R><K><Y><E><A><M><T><K><L><G><F><K><A><I><L><P><S><F><M><R><N><K><R><V><T><D><F><Q><G><N><D><F><D><N><D><P><N><R><G><N><Q><V><Q><R><P><Q><M><T><F><G><R><L><Q><G><I><F><P><K><I><M><P><K><K><P><A><E><E><G><N><V><S><K><E><V><P><E><A><S><G><P><Q><N><D><G><K><Q><L><C><P><P><G><K><P><T><T><S><E><K><I><N><M><I><S><G><P><K><R><G><E><H><A><W><T><H><R><L><R><E><R><K><Q><L><V><I><Y><E><E><I><S><D><P><E><E><D><D><E>	Could act as a modulator of transcription.<BOP>	Q99909
Q9UKT8	FBXW2_HUMAN	Protein MD6	Homo	<M><E><R><K><D><F><E><T><W><L><D><N><I><S><V><T><F><L><S><L><T><D><L><Q><K><N><E><T><L><D><H><L><I><S><L><S><G><A><V><Q><L><R><H><L><S><N><N><L><E><T><L><L><K><R><D><F><L><K><L><L><P><L><E><L><S><F><Y><L><L><K><W><L><D><P><Q><T><L><L><T><C><C><L><V><S><K><Q><W><N><K><V><I><S><A><C><T><E><V><W><Q><T><A><C><K><N><L><G><W><Q><I><D><D><S><V><Q><D><A><L><H><W><K><K><V><Y><L><K><A><I><L><R><M><K><Q><L><E><D><H><E><A><F><E><T><S><S><L><I><G><H><S><A><R><V><Y><A><L><Y><Y><K><D><G><L><L><C><T><G><S><D><D><L><S><A><K><L><W><D><V><S><T><G><Q><C><V><Y><G><I><Q><T><H><T><C><A><A><V><K><F><D><E><Q><K><L><V><T><G><S><F><D><N><T><V><A><C><W><E><W><S><S><G><A><R><T><Q><H><F><R><G><H><T><G><A><V><F><S><V><D><Y><N><D><E><L><D><I><L><V><S><G><S><A><D><F><T><V><K><V><W><A><L><S><A><G><T><C><L><N><T><L><T><G><H><T><E><W><V><T><K><V><V><L><Q><K><C><K><V><K><S><L><L><H><S><P><G><D><Y><I><L><L><S><A><D><K><Y><E><I><K><I><W><P><I><G><R><E><I><N><C><K><C><L><K><T><L><S><V><S><E><D><R><S><I><C><L><Q><P><R><L><H><F><D><G><K><Y><I><V><C><S><S><A><L><G><L><Y><Q><W><D><F><A><S><Y><D><I><L><R><V><I><K><T><P><E><I><A><N><L><A><L><L><G><F><G><D><I><F><A><L><L><F><D><N><R><Y><L><Y><I><M><D><L><R><T><E><S><L><I><S><R><W><P><L><P><E><Y><R><K><S><K><R><G><S><S><F><L><A><G><E><A><S><W><L><N><G><L><D><G><H><N><D><T><G><L><V><F><A><T><S><M><P><D><H><S><I><H><L><V><L><W><K><E><H><G>	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>	Q9UKT8
Q9NST1	PLPL3_HUMAN	Patatin-like phospholipase domain-containing protein 3	Homo	<M><Y><D><A><E><R><G><W><S><L><S><F><A><G><C><G><F><L><G><F><Y><H><V><G><A><T><R><C><L><S><E><H><A><P><H><L><L><R><D><A><R><M><L><F><G><A><S><A><G><A><L><H><C><V><G><V><L><S><G><I><P><L><E><Q><T><L><Q><V><L><S><D><L><V><R><K><A><R><S><R><N><I><G><I><F><H><P><S><F><N><L><S><K><F><L><R><Q><G><L><C><K><C><L><P><A><N><V><H><Q><L><I><S><G><K><I><G><I><S><L><T><R><V><S><D><G><E><N><V><L><V><S><D><F><R><S><K><D><E><V><V><D><A><L><V><C><S><C><F><I><P><F><Y><S><G><L><I><P><P><S><F><R><G><V><R><Y><V><D><G><G><V><S><D><N><V><P><F><I><D><A><K><T><T><I><T><V><S><P><F><Y><G><E><Y><D><I><C><P><K><V><K><S><T><N><F><L><H><V><D><I><T><K><L><S><L><R><L><C><T><G><N><L><Y><L><L><S><R><A><F><V><P><P><D><L><K><V><L><G><E><I><C><L><R><G><Y><L><D><A><F><R><F><L><E><E><K><G><I><C><N><R><P><Q><P><G><L><K><S><S><S><E><G><M><D><P><E><V><A><M><P><S><W><A><N><M><S><L><D><S><S><P><E><S><A><A><L><A><V><R><L><E><G><D><E><L><L><D><H><L><R><L><S><I><L><P><W><D><E><S><I><L><D><T><L><S><P><R><L><A><T><A><L><S><E><E><M><K><D><K><G><G><Y><M><S><K><I><C><N><L><L><P><I><R><I><M><S><Y><V><M><L><P><C><T><L><P><V><E><S><A><I><A><I><V><Q><R><L><V><T><W><L><P><D><M><P><D><D><V><L><W><L><Q><W><V><T><S><Q><V><F><T><R><V><L><M><C><L><L><P><A><S><R><S><Q><M><P><V><S><S><Q><Q><A><S><P><C><T><P><E><Q><D><W><P><C><W><T><P><C><S><P><K><G><C><P><A><E><T><K><A><E><A><T><P><R><S><I><L><R><S><S><L><N><F><F><L><G><N><K><V><P><A><G><A><E><G><L><S><T><F><P><S><F><S><L><E><K><S><L>	Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA . Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides . Has hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety . Possesses phospholipase A2 activity .<BOP>	Q9NST1

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