accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q86X83
COMD2_HUMAN
COMM domain-containing protein 2
Homo
<M><L><L><E><L><S><E><E><H><K><E><H><L><A><F><L><P><Q><V><D><S><A><V><V><A><E><F><G><R><I><A><V><E><F><L><R><R><G><A><N><P><K><I><Y><E><G><A><A><R><K><L><N><V><S><S><D><T><V><Q><H><G><V><E><G><L><T><Y><L><L><T><E><S><S><K><L><M><I><S><E><L><D><F><Q><D><S><V><F><V><L><G><F><S><E><E><L><N><K><L><L><L><Q><L><Y><L><D><N><R><K><E><I><R><T><I><L><S><E><L><A><P><S><L><P><S><Y><H><N><L><E><W><R><L><D><V><Q><L><A><S><R><S><L><R><Q><Q><I><K><P><A><V><T><I><K><L><H><L><N><Q><N><G><D><H><N><T><K><V><L><Q><T><D><P><A><T><L><L><H><L><V><Q><Q><L><E><Q><A><L><E><E><M><K><T><N><H><C><R><R><V><V><R><N><I><K>
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . May down-regulate activation of NF-kappa-B .<BOP>
Q86X83
O76096
CYTF_HUMAN
Leukocystatin
Homo
<M><R><A><A><G><T><L><L><A><F><C><C><L><V><L><S><T><T><G><G><P><S><P><D><T><C><S><Q><D><L><N><S><R><V><K><P><G><F><P><K><T><I><K><T><N><D><P><G><V><L><Q><A><A><R><Y><S><V><E><K><F><N><N><C><T><N><D><M><F><L><F><K><E><S><R><I><T><R><A><L><V><Q><I><V><K><G><L><K><Y><M><L><E><V><E><I><G><R><T><T><C><K><K><N><Q><H><L><R><L><D><D><C><D><F><Q><T><N><H><T><L><K><Q><T><L><S><C><Y><S><E><V><W><V><V><P><W><L><Q><H><F><E><V><P><V><L><R><C><H>
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.<BOP>
O76096
P49795
RGS19_HUMAN
G-alpha-interacting protein
Homo
<M><P><T><P><H><E><A><E><K><Q><I><T><G><P><E><E><A><D><R><P><P><S><M><S><S><H><D><T><A><S><P><A><A><P><S><R><N><P><C><C><L><C><W><C><C><C><C><S><C><S><W><N><Q><E><R><R><R><A><W><Q><A><S><R><E><S><K><L><Q><P><L><P><S><C><E><V><C><A><T><P><S><P><E><E><V><Q><S><W><A><Q><S><F><D><K><L><M><H><S><P><A><G><R><S><V><F><R><A><F><L><R><T><E><Y><S><E><E><N><M><L><F><W><L><A><C><E><E><L><K><A><E><A><N><Q><H><V><V><D><E><K><A><R><L><I><Y><E><D><Y><V><S><I><L><S><P><K><E><V><S><L><D><S><R><V><R><E><G><I><N><K><K><M><Q><E><P><S><A><H><T><F><D><D><A><Q><L><Q><I><Y><T><L><M><H><R><D><S><Y><P><R><F><L><S><S><P><T><Y><R><A><L><L><L><Q><G><P><S><Q><S><S><S><E><A>
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.<BOP>
P49795
Q9ULC0
MUCEN_HUMAN
Mucin-14
Homo
<M><E><L><L><Q><V><T><I><L><F><L><L><P><S><I><C><S><S><N><S><T><G><V><L><E><A><A><N><N><S><L><V><V><T><T><T><K><P><S><I><T><T><P><N><T><E><S><L><Q><K><N><V><V><T><P><T><T><G><T><T><P><K><G><T><I><T><N><E><L><L><K><M><S><L><M><S><T><A><T><F><L><T><S><K><D><E><G><L><K><A><T><T><T><D><V><R><K><N><D><S><I><I><S><N><V><T><V><T><S><V><T><L><P><N><A><V><S><T><L><Q><S><S><K><P><K><T><E><T><Q><S><S><I><K><T><T><E><I><P><G><S><V><L><Q><P><D><A><S><P><S><K><T><G><T><L><T><S><I><P><V><T><I><P><E><N><T><S><Q><S><Q><V><I><G><T><E><G><G><K><N><A><S><T><S><A><T><S><R><S><Y><S><S><I><I><L><P><V><V><I><A><L><I><V><I><T><L><S><V><F><V><L><V><G><L><Y><R><M><C><W><K><A><D><P><G><T><P><E><N><G><N><D><Q><P><Q><S><D><K><E><S><V><K><L><L><T><V><K><T><I><S><H><E><S><G><E><H><S><A><Q><G><K><T><K><N>
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.<BOP>
Q9ULC0
Q14244
MAP7_HUMAN
Microtubule-associated protein 7
Homo
<M><A><E><L><G><A><G><G><D><G><H><R><G><G><D><G><A><V><R><S><E><T><A><P><D><S><Y><K><V><Q><D><K><K><N><A><S><S><R><P><A><S><A><I><S><G><Q><N><N><N><H><S><G><N><K><P><D><P><P><P><V><L><R><V><D><D><R><Q><R><L><A><R><E><R><R><E><E><R><E><K><Q><L><A><A><R><E><I><V><W><L><E><R><E><E><R><A><R><Q><H><Y><E><K><H><L><E><E><R><K><K><R><L><E><E><Q><R><Q><K><E><E><R><R><R><A><A><V><E><E><K><R><R><Q><R><L><E><E><D><K><E><R><H><E><A><V><V><R><R><T><M><E><R><S><Q><K><P><K><Q><K><H><N><R><W><S><W><G><G><S><L><H><G><S><P><S><I><H><S><A><D><P><D><R><R><S><V><S><T><M><N><L><S><K><Y><V><D><P><V><I><S><K><R><L><S><S><S><S><A><T><L><L><N><S><P><D><R><A><R><R><L><Q><L><S><P><W><E><S><S><V><V><N><R><L><L><T><P><T><H><S><F><L><A><R><S><K><S><T><A><A><L><S><G><E><A><A><S><C><S><P><I><I><M><P><Y><K><A><A><H><S><R><N><S><M><D><R><P><K><L><F><V><T><P><P><E><G><S><S><R><R><R><I><I><H><G><T><A><S><Y><K><K><E><R><E><R><E><N><V><L><F><L><T><S><G><T><R><R><A><V><S><P><S><N><P><K><A><R><Q><P><A><R><S><R><L><W><L><P><S><K><S><L><P><H><L><P><G><T><P><R><P><T><S><S><L><P><P><G><S><V><K><A><A><P><A><Q><V><R><P><P><S><P><G><N><I><R><P><V><K><R><E><V><K><V><E><P><E><K><K><D><P><E><K><E><P><Q><K><V><A><N><E><P><S><L><K><G><R><A><P><L><V><K><V><E><E><A><T><V><E><E><R><T><P><A><E><P><E><V><G><P><A><A><P><A><M><A><P><A><P><A><S><A><P><A><P><A><S><A><P><A><P><A><P><V><P><T><P><A><M><V><S><A><P><S><S><T><V><N><A><S><A><S><V><K><T><S><A><G><T><T><D><P><E><E><A><T><R><L><L><A><E><K><R><R><L><A><R><E><Q><R><E><K><E><E><R><E><R><R><E><Q><E><E><L><E><R><Q><K><R><E><E><L><A><Q><R><V><A><E><E><R><T><T><R><R><E><E><E><S><R><R><L><E><A><E><Q><A><R><E><K><E><E><Q><L><Q><R><Q><A><E><E><R><A><L><R><E><R><E><E><A><E><R><A><Q><R><Q><K><E><E><E><A><R><V><R><E><E><A><E><R><V><R><Q><E><R><E><K><H><F><Q><R><E><E><Q><E><R><L><E><R><K><K><R><L><E><E><I><M><K><R><T><R><R><T><E><A><T><D><K><K><T><S><D><Q><R><N><G><D><I><A><K><G><A><L><T><G><G><T><E><V><S><A><L><P><C><T><T><N><A><P><G><N><G><K><P><V><G><S><P><H><V><V><T><S><H><Q><S><K><V><T><V><E><S><T><P><D><L><E><K><Q><P><N><E><N><G><V><S><V><Q><N><E><N><F><E><E><I><I><N><L><P><I><G><S><K><P><S><R><L><D><V><T><N><S><E><S><P><E><I><P><L><N><P><I><L><A><F><D><D><E><G><T><L><G><P><L><P><Q><V><D><G><V><Q><T><Q><Q><T><A><E><V><I>
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.<BOP>
Q14244
Q7Z7K0
COXM1_HUMAN
COX assembly mitochondrial protein homolog
Homo
<M><A><L><D><P><A><D><Q><H><L><R><H><V><E><K><D><V><L><I><P><K><I><M><R><E><K><A><K><E><R><C><S><E><Q><V><Q><D><F><T><K><C><C><K><N><S><G><V><L><M><V><V><K><C><R><K><E><N><S><A><L><K><E><C><L><T><A><Y><Y><N><D><P><A><F><Y><E><E><C><K><M><E><Y><L><K><E><R><E><E><F><R><K><T><G><I><P><T><K><K><R><L><Q><K><L><P><T><S><M>
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.<BOP>
Q7Z7K0
Q96HN2
SAHH3_HUMAN
S-adenosylhomocysteine hydrolase-like protein 2
Homo
<M><S><V><Q><V><V><S><A><A><A><A><A><K><V><P><E><V><E><L><K><D><L><S><P><S><E><A><E><S><Q><L><G><L><S><T><A><A><V><G><A><M><A><P><P><A><G><G><G><D><P><E><A><P><A><P><A><A><E><R><P><P><V><P><G><P><G><S><G><P><A><A><A><L><S><P><A><A><G><K><V><P><Q><A><S><A><M><K><R><S><D><P><H><H><Q><H><Q><R><H><R><D><G><G><E><A><L><V><S><P><D><G><T><V><T><E><A><P><R><T><V><K><K><Q><I><Q><F><A><D><Q><K><Q><E><F><N><K><R><P><T><K><I><G><R><R><S><L><S><R><S><I><S><Q><S><S><T><D><S><Y><S><S><A><A><S><Y><T><D><S><S><D><D><E><T><S><P><R><D><K><Q><Q><K><N><S><K><G><S><S><D><F><C><V><K><N><I><K><Q><A><E><F><G><R><R><E><I><E><I><A><E><Q><E><M><P><A><L><M><A><L><R><K><R><A><Q><G><E><K><P><L><A><G><A><K><I><V><G><C><T><H><I><T><A><Q><T><A><V><L><M><E><T><L><G><A><L><G><A><Q><C><R><W><A><A><C><N><I><Y><S><T><L><N><E><V><A><A><A><L><A><E><S><G><F><P><V><F><A><W><K><G><E><S><E><D><D><F><W><W><C><I><D><R><C><V><N><V><E><G><W><Q><P><N><M><I><L><D><D><G><G><D><L><T><H><W><I><Y><K><K><Y><P><N><M><F><K><K><I><K><G><I><V><E><E><S><V><T><G><V><H><R><L><Y><Q><L><S><K><A><G><K><L><C><V><P><A><M><N><V><N><D><S><V><T><K><Q><K><F><D><N><L><Y><C><C><R><E><S><I><L><D><G><L><K><R><T><T><D><M><M><F><G><G><K><Q><V><V><V><C><G><Y><G><E><V><G><K><G><C><C><A><A><L><K><A><M><G><S><I><V><Y><V><T><E><I><D><P><I><C><A><L><Q><A><C><M><D><G><F><R><L><V><K><L><N><E><V><I><R><Q><V><D><I><V><I><T><C><T><G><N><K><N><V><V><T><R><E><H><L><D><R><M><K><N><S><C><I><V><C><N><M><G><H><S><N><T><E><I><D><V><A><S><L><R><T><P><E><L><T><W><E><R><V><R><S><Q><V><D><H><V><I><W><P><D><G><K><R><I><V><L><L><A><E><G><R><L><L><N><L><S><C><S><T><V><P><T><F><V><L><S><I><T><A><T><T><Q><A><L><A><L><I><E><L><Y><N><A><P><E><G><R><Y><K><Q><D><V><Y><L><L><P><K><K><M><D><E><Y><V><A><S><L><H><L><P><T><F><D><A><H><L><T><E><L><T><D><E><Q><A><K><Y><L><G><L><N><K><N><G><P><F><K><P><N><Y><Y><R><Y>
May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate .<BOP>
Q96HN2
P14210
HGF_HUMAN
Hepatocyte growth factor beta chain
Homo
<M><W><V><T><K><L><L><P><A><L><L><L><Q><H><V><L><L><H><L><L><L><L><P><I><A><I><P><Y><A><E><G><Q><R><K><R><R><N><T><I><H><E><F><K><K><S><A><K><T><T><L><I><K><I><D><P><A><L><K><I><K><T><K><K><V><N><T><A><D><Q><C><A><N><R><C><T><R><N><K><G><L><P><F><T><C><K><A><F><V><F><D><K><A><R><K><Q><C><L><W><F><P><F><N><S><M><S><S><G><V><K><K><E><F><G><H><E><F><D><L><Y><E><N><K><D><Y><I><R><N><C><I><I><G><K><G><R><S><Y><K><G><T><V><S><I><T><K><S><G><I><K><C><Q><P><W><S><S><M><I><P><H><E><H><S><F><L><P><S><S><Y><R><G><K><D><L><Q><E><N><Y><C><R><N><P><R><G><E><E><G><G><P><W><C><F><T><S><N><P><E><V><R><Y><E><V><C><D><I><P><Q><C><S><E><V><E><C><M><T><C><N><G><E><S><Y><R><G><L><M><D><H><T><E><S><G><K><I><C><Q><R><W><D><H><Q><T><P><H><R><H><K><F><L><P><E><R><Y><P><D><K><G><F><D><D><N><Y><C><R><N><P><D><G><Q><P><R><P><W><C><Y><T><L><D><P><H><T><R><W><E><Y><C><A><I><K><T><C><A><D><N><T><M><N><D><T><D><V><P><L><E><T><T><E><C><I><Q><G><Q><G><E><G><Y><R><G><T><V><N><T><I><W><N><G><I><P><C><Q><R><W><D><S><Q><Y><P><H><E><H><D><M><T><P><E><N><F><K><C><K><D><L><R><E><N><Y><C><R><N><P><D><G><S><E><S><P><W><C><F><T><T><D><P><N><I><R><V><G><Y><C><S><Q><I><P><N><C><D><M><S><H><G><Q><D><C><Y><R><G><N><G><K><N><Y><M><G><N><L><S><Q><T><R><S><G><L><T><C><S><M><W><D><K><N><M><E><D><L><H><R><H><I><F><W><E><P><D><A><S><K><L><N><E><N><Y><C><R><N><P><D><D><D><A><H><G><P><W><C><Y><T><G><N><P><L><I><P><W><D><Y><C><P><I><S><R><C><E><G><D><T><T><P><T><I><V><N><L><D><H><P><V><I><S><C><A><K><T><K><Q><L><R><V><V><N><G><I><P><T><R><T><N><I><G><W><M><V><S><L><R><Y><R><N><K><H><I><C><G><G><S><L><I><K><E><S><W><V><L><T><A><R><Q><C><F><P><S><R><D><L><K><D><Y><E><A><W><L><G><I><H><D><V><H><G><R><G><D><E><K><C><K><Q><V><L><N><V><S><Q><L><V><Y><G><P><E><G><S><D><L><V><L><M><K><L><A><R><P><A><V><L><D><D><F><V><S><T><I><D><L><P><N><Y><G><C><T><I><P><E><K><T><S><C><S><V><Y><G><W><G><Y><T><G><L><I><N><Y><D><G><L><L><R><V><A><H><L><Y><I><M><G><N><E><K><C><S><Q><H><H><R><G><K><V><T><L><N><E><S><E><I><C><A><G><A><E><K><I><G><S><G><P><C><E><G><D><Y><G><G><P><L><V><C><E><Q><H><K><M><R><M><V><L><G><V><I><V><P><G><R><G><C><A><I><P><N><R><P><G><I><F><V><R><V><A><Y><Y><A><K><W><I><H><K><I><I><L><T><Y><K><V><P><Q><S>
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<BOP>
P14210
Q9NRY7
PLS2_HUMAN
Ca(2+)-dependent phospholipid scramblase 2
Homo
<M><R><S><W><N><S><L><F><C><L><N><S><S><R><P><P><G><H><I><V><Y><P><K><H><Q><A><G><H><T><G><K><Q><A><D><H><L><G><S><Q><A><F><Y><P><G><R><Q><H><D><Y><L><V><P><P><A><G><T><A><G><I><P><V><Q><N><Q><P><G><R><P><E><G><V><P><W><M><P><A><P><P><P><P><L><N><C><P><P><G><L><E><Y><L><S><Q><I><D><M><I><L><I><H><Q><Q><I><E><L><L><E><V><L><F><S><F><E><S><S><N><M><Y><E><I><K><N><S><F><G><Q><R><I><Y><F><A><A><E><D><T><N><F><C><I><R><N><C><C><G><R><S><R><P><F><T><L><R><I><T><D><N><V><G><R><E><V><I><T><L><E><R><P><L><R><C><N><C><C><C><C><P><C><C><L><Q><E><I><E><I><Q><A><P><P><G><V><P><V><G><Y><V><T><Q><T><W><H><P><C><L><T><K><F><T><I><K><N><Q><K><R><E><D><V><L><K><I><S><G><P><C><I><V><C><S><C><I><A><G><V><D><F><E><I><T><S><L><D><E><Q><I><V><V><G><R><I><S><K><H><W><S><G><F><L><R><E><A><F><T><D><A><D><N><F><G><I><Q><F><P><R><D><L><D><V><K><M><K><A><V><M><I><G><A><C><F><L><I><D><Y><M><F><F><E><R><T><R>
Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.<BOP>
Q9NRY7
P0DP06
HVD34_HUMAN
Immunoglobulin heavy variable 4-30-4
Homo
<M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><V><Q><L><Q><E><S><G><P><G><L><V><K><P><S><Q><T><L><S><L><T><C><T><V><S><G><G><S><I><S><S><G><D><Y><Y><W><S><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><Y><I><Y><Y><S><G><S><T><Y><Y><N><P><S><L><K><S><R><V><T><I><S><V><D><T><S><K><N><Q><F><S><L><K><L><S><S><V><T><A><A><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DP06
Q6ZVZ8
ASB18_HUMAN
Ankyrin repeat and SOCS box protein 18
Homo
<M><S><N><S><D><Y><L><P><D><Y><P><L><N><S><D><L><V><K><R><L><K><S><A><L><D><A><K><D><E><E><R><V><R><D><L><I><C><T><E><I><T><P><V><D><A><V><I><E><L><A><N><D><D><W><M><K><D><P><S><A><Q><L><P><T><G><M><L><L><G><D><L><D><H><L><K><P><L><M><D><Q><F><F><Q><D><A><N><V><V><F><E><I><N><K><D><E><M><E><W><Q><V><K><S><P><A><T><F><G><L><S><G><L><W><T><L><E><Y><K><R><E><L><T><T><P><L><C><I><A><A><A><H><G><H><T><A><C><V><R><H><L><L><G><R><G><A><D><P><D><A><S><P><G><G><R><G><A><L><H><E><A><C><L><G><G><H><T><A><C><V><R><L><L><L><Q><H><R><A><D><P><D><L><L><S><A><E><G><L><A><P><L><H><L><C><R><T><A><A><S><L><G><C><A><Q><A><L><L><E><H><G><A><S><V><Q><R><V><G><G><T><G><R><D><T><P><L><H><V><A><A><Q><R><G><L><D><E><H><A><R><L><Y><L><G><R><G><A><H><V><D><A><R><N><G><R><G><E><T><A><L><S><A><A><C><G><A><A><R><R><P><D><E><H><G><R><C><L><R><L><C><A><L><L><L><R><R><G><A><E><A><D><A><R><D><E><D><E><R><S><P><L><H><K><A><C><G><H><A><S><H><S><L><A><R><L><L><L><R><H><G><A><D><A><G><A><L><D><Y><G><G><A><S><P><L><G><R><V><L><Q><T><A><S><C><A><L><Q><A><S><P><Q><R><T><V><Q><A><L><L><N><H><G><S><P><T><V><W><P><D><A><F><P><K><V><L><K><T><C><A><S><V><P><A><V><I><E><V><L><F><N><S><Y><P><Q><L><C><L><S><E><S><W><K><E><V><I><P><E><E><V><F><Q><M><H><K><P><F><Y><Q><S><L><F><A><L><A><L><T><P><R><C><L><Q><H><L><C><R><C><A><L><R><R><L><F><G><K><R><C><F><D><L><I><P><L><L><P><L><P><K><P><L><Q><N><Y><L><L><L><E><P><Q><G><V><L><H>
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
Q6ZVZ8
Q5JT25
RAB41_HUMAN
Ras-related protein Rab-41
Homo
<M><S><A><F><G><H><D><E><A><W><M><E><A><G><G><F><G><L><E><A><A><E><R><T><E><Y><Q><S><L><C><K><S><K><L><L><F><L><G><E><Q><S><V><G><K><T><S><I><I><S><R><F><M><Y><N><S><F><G><C><A><C><Q><A><T><V><G><I><D><F><L><S><K><T><M><Y><L><E><D><Q><I><V><Q><L><Q><L><W><D><T><A><G><Q><E><R><F><H><S><L><I><P><S><Y><I><R><D><S><T><I><A><V><V><V><Y><D><I><T><N><I><N><S><F><K><E><T><D><K><W><V><E><H><V><R><A><E><R><G><D><D><V><V><I><M><L><L><G><N><K><I><D><L><D><N><K><R><Q><V><T><A><E><Q><G><E><E><K><S><R><N><L><N><V><M><F><I><E><T><S><A><K><T><G><Y><N><V><K><K><L><F><R><R><V><A><S><A><L><L><S><T><R><T><S><P><P><P><K><E><G><T><V><E><I><E><L><E><S><F><E><E><S><G><N><R><S><Y><C>
Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.<BOP>
Q5JT25
Q9Y2V0
CDIN1_HUMAN
Protein HH114
Homo
<M><I><L><T><K><A><Q><Y><D><E><I><A><Q><C><L><V><S><V><P><P><T><R><Q><S><L><R><K><L><K><Q><R><F><P><S><Q><S><Q><A><T><L><L><S><I><F><S><Q><E><Y><Q><K><H><I><K><R><T><H><A><K><H><H><T><S><E><A><I><E><S><Y><Y><Q><R><Y><L><N><G><V><V><K><N><G><A><A><P><V><L><L><D><L><A><N><E><V><D><Y><A><P><S><L><M><A><R><L><I><L><E><R><F><L><Q><E><H><E><E><T><P><P><S><K><S><I><I><N><S><M><L><R><D><P><S><Q><I><P><D><G><V><L><A><N><Q><V><Y><Q><C><I><V><N><D><C><C><Y><G><P><L><V><D><C><I><K><H><A><I><G><H><E><H><E><V><L><L><R><D><L><L><L><E><K><N><L><S><F><L><D><E><D><Q><L><R><A><K><G><Y><D><K><T><P><D><F><I><L><Q><V><P><V><A><V><E><G><H><I><I><H><W><I><E><S><K><A><S><F><G><D><E><C><S><H><H><A><Y><L><H><D><Q><F><W><S><Y><W><N><R><F><G><P><G><L><V><I><Y><W><Y><G><F><I><Q><E><L><D><C><N><R><E><R><G><I><L><L><K><A><C><F><P><T><N><I><V><T><L><C><H><S><I><A>
Plays a role in erythroid cell differentiation.<BOP>
Q9Y2V0
Q9UHY1
NRBP_HUMAN
Nuclear receptor-binding protein
Homo
<M><S><E><G><E><S><Q><T><V><L><S><S><G><S><D><P><K><V><E><S><S><S><S><A><P><G><L><T><S><V><S><P><P><V><T><S><T><T><S><A><A><S><P><E><E><E><E><E><S><E><D><E><S><E><I><L><E><E><S><P><C><G><R><W><Q><K><R><R><E><E><V><N><Q><R><N><V><P><G><I><D><S><A><Y><L><A><M><D><T><E><E><G><V><E><V><V><W><N><E><V><Q><F><S><E><R><K><N><Y><K><L><Q><E><E><K><V><R><A><V><F><D><N><L><I><Q><L><E><H><L><N><I><V><K><F><H><K><Y><W><A><D><I><K><E><N><K><A><R><V><I><F><I><T><E><Y><M><S><S><G><S><L><K><Q><F><L><K><K><T><K><K><N><H><K><T><M><N><E><K><A><W><K><R><W><C><T><Q><I><L><S><A><L><S><Y><L><H><S><C><D><P><P><I><I><H><G><N><L><T><C><D><T><I><F><I><Q><H><N><G><L><I><K><I><G><S><V><A><P><D><T><I><N><N><H><V><K><T><C><R><E><E><Q><K><N><L><H><F><F><A><P><E><Y><G><E><V><T><N><V><T><T><A><V><D><I><Y><S><F><G><M><C><A><L><E><M><A><V><L><E><I><Q><G><N><G><E><S><S><Y><V><P><Q><E><A><I><S><S><A><I><Q><L><L><E><D><P><L><Q><R><E><F><I><Q><K><C><L><Q><S><E><P><A><R><R><P><T><A><R><E><L><L><F><H><P><A><L><F><E><V><P><S><L><K><L><L><A><A><H><C><I><V><G><H><Q><H><M><I><P><E><N><A><L><E><E><I><T><K><N><M><D><T><S><A><V><L><A><E><I><P><A><G><P><G><R><E><P><V><Q><T><L><Y><S><Q><S><P><A><L><E><L><D><K><F><L><E><D><V><R><N><G><I><Y><P><L><T><A><F><G><L><P><R><P><Q><Q><P><Q><Q><E><E><V><T><S><P><V><V><P><P><S><V><K><T><P><T><P><E><P><A><E><V><E><T><R><K><V><V><L><M><Q><C><N><I><E><S><V><E><E><G><V><K><H><H><L><T><L><L><L><K><L><E><D><K><L><N><R><H><L><S><C><D><L><M><P><N><E><N><I><P><E><L><A><A><E><L><V><Q><L><G><F><I><S><E><A><D><Q><S><R><L><T><S><L><L><E><E><T><L><N><K><F><N><F><A><R><N><S><T><L><N><S><A><A><V><T><V><S><S>
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.<BOP>
Q9UHY1
P15036
ETS2_HUMAN
Protein C-ets-2
Homo
<M><N><D><F><G><I><K><N><M><D><Q><V><A><P><V><A><N><S><Y><R><G><T><L><K><R><Q><P><A><F><D><T><F><D><G><S><L><F><A><V><F><P><S><L><N><E><E><Q><T><L><Q><E><V><P><T><G><L><D><S><I><S><H><D><S><A><N><C><E><L><P><L><L><T><P><C><S><K><A><V><M><S><Q><A><L><K><A><T><F><S><G><F><K><K><E><Q><R><R><L><G><I><P><K><N><P><W><L><W><S><E><Q><Q><V><C><Q><W><L><L><W><A><T><N><E><F><S><L><V><N><V><N><L><Q><R><F><G><M><N><G><Q><M><L><C><N><L><G><K><E><R><F><L><E><L><A><P><D><F><V><G><D><I><L><W><E><H><L><E><Q><M><I><K><E><N><Q><E><K><T><E><D><Q><Y><E><E><N><S><H><L><T><S><V><P><H><W><I><N><S><N><T><L><G><F><G><T><E><Q><A><P><Y><G><M><Q><T><Q><N><Y><P><K><G><G><L><L><D><S><M><C><P><A><S><T><P><S><V><L><S><S><E><Q><E><F><Q><M><F><P><K><S><R><L><S><S><V><S><V><T><Y><C><S><V><S><Q><D><F><P><G><S><N><L><N><L><L><T><N><N><S><G><T><P><K><D><H><D><S><P><E><N><G><A><D><S><F><E><S><S><D><S><L><L><Q><S><W><N><S><Q><S><S><L><L><D><V><Q><R><V><P><S><F><E><S><F><E><D><D><C><S><Q><S><L><C><L><N><K><P><T><M><S><F><K><D><Y><I><Q><E><R><S><D><P><V><E><Q><G><K><P><V><I><P><A><A><V><L><A><G><F><T><G><S><G><P><I><Q><L><W><Q><F><L><L><E><L><L><S><D><K><S><C><Q><S><F><I><S><W><T><G><D><G><W><E><F><K><L><A><D><P><D><E><V><A><R><R><W><G><K><R><K><N><K><P><K><M><N><Y><E><K><L><S><R><G><L><R><Y><Y><Y><D><K><N><I><I><H><K><T><S><G><K><R><Y><V><Y><R><F><V><C><D><L><Q><N><L><L><G><F><T><P><E><E><L><H><A><I><L><G><V><Q><P><D><T><E><D>
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.<BOP>
P15036
Q16655
MAR1_HUMAN
Protein Melan-A
Homo
<M><P><R><E><D><A><H><F><I><Y><G><Y><P><K><K><G><H><G><H><S><Y><T><T><A><E><E><A><A><G><I><G><I><L><T><V><I><L><G><V><L><L><L><I><G><C><W><Y><C><R><R><R><N><G><Y><R><A><L><M><D><K><S><L><H><V><G><T><Q><C><A><L><T><R><R><C><P><Q><E><G><F><D><H><R><D><S><K><V><S><L><Q><E><K><N><C><E><P><V><V><P><N><A><P><P><A><Y><E><K><L><S><A><E><Q><S><P><P><P><Y><S><P>
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.<BOP>
Q16655
Q13239
SLAP1_HUMAN
Src-like-adapter protein 1
Homo
<M><G><N><S><M><K><S><T><P><A><P><A><E><R><P><L><P><N><P><E><G><L><D><S><D><F><L><A><V><L><S><D><Y><P><S><P><D><I><S><P><P><I><F><R><R><G><E><K><L><R><V><I><S><D><E><G><G><W><W><K><A><I><S><L><S><T><G><R><E><S><Y><I><P><G><I><C><V><A><R><V><Y><H><G><W><L><F><E><G><L><G><R><D><K><A><E><E><L><L><Q><L><P><D><T><K><V><G><S><F><M><I><R><E><S><E><T><K><K><G><F><Y><S><L><S><V><R><H><R><Q><V><K><H><Y><R><I><F><R><L><P><N><N><W><Y><Y><I><S><P><R><L><T><F><Q><C><L><E><D><L><V><N><H><Y><S><E><V><A><D><G><L><C><C><V><L><T><T><P><C><L><T><Q><S><T><A><A><P><A><V><R><A><S><S><S><P><V><T><L><R><Q><K><T><V><D><W><R><R><V><S><R><L><Q><E><D><P><E><G><T><E><N><P><L><G><V><D><E><S><L><F><S><Y><G><L><R><E><S><I><A><S><Y><L><S><L><T><S><E><D><N><T><S><F><D><R><K><K><K><S><I><S><L><M><Y><G><G><S><K><R><K><S><S><F><F><S><S><P><P><Y><F><E><D>
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.<BOP>
Q13239
Q16769
QPCT_HUMAN
Glutamyl cyclase
Homo
<M><A><G><G><R><H><R><R><V><V><G><T><L><H><L><L><L><L><V><A><A><L><P><W><A><S><R><G><V><S><P><S><A><S><A><W><P><E><E><K><N><Y><H><Q><P><A><I><L><N><S><S><A><L><R><Q><I><A><E><G><T><S><I><S><E><M><W><Q><N><D><L><Q><P><L><L><I><E><R><Y><P><G><S><P><G><S><Y><A><A><R><Q><H><I><M><Q><R><I><Q><R><L><Q><A><D><W><V><L><E><I><D><T><F><L><S><Q><T><P><Y><G><Y><R><S><F><S><N><I><I><S><T><L><N><P><T><A><K><R><H><L><V><L><A><C><H><Y><D><S><K><Y><F><S><H><W><N><N><R><V><F><V><G><A><T><D><S><A><V><P><C><A><M><M><L><E><L><A><R><A><L><D><K><K><L><L><S><L><K><T><V><S><D><S><K><P><D><L><S><L><Q><L><I><F><F><D><G><E><E><A><F><L><H><W><S><P><Q><D><S><L><Y><G><S><R><H><L><A><A><K><M><A><S><T><P><H><P><P><G><A><R><G><T><S><Q><L><H><G><M><D><L><L><V><L><L><D><L><I><G><A><P><N><P><T><F><P><N><F><F><P><N><S><A><R><W><F><E><R><L><Q><A><I><E><H><E><L><H><E><L><G><L><L><K><D><H><S><L><E><G><R><Y><F><Q><N><Y><S><Y><G><G><V><I><Q><D><D><H><I><P><F><L><R><R><G><V><P><V><L><H><L><I><P><S><P><F><P><E><V><W><H><T><M><D><D><N><E><E><N><L><D><E><S><T><I><D><N><L><N><K><I><L><Q><V><F><V><L><E><Y><L><H><L>
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.<BOP>
Q16769
P51668
UB2D1_HUMAN
Ubiquitin-protein ligase D1
Homo
<M><A><L><K><R><I><Q><K><E><L><S><D><L><Q><R><D><P><P><A><H><C><S><A><G><P><V><G><D><D><L><F><H><W><Q><A><T><I><M><G><P><P><D><S><A><Y><Q><G><G><V><F><F><L><T><V><H><F><P><T><D><Y><P><F><K><P><P><K><I><A><F><T><T><K><I><Y><H><P><N><I><N><S><N><G><S><I><C><L><D><I><L><R><S><Q><W><S><P><A><L><T><V><S><K><V><L><L><S><I><C><S><L><L><C><D><P><N><P><D><D><P><L><V><P><D><I><A><Q><I><Y><K><S><D><K><E><K><Y><N><R><H><A><R><E><W><T><Q><K><Y><A><M>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . In vitro catalyzes 'Lys-48'-linked polyubiquitination . Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 . Ubiquitinates STUB1-associated HSP90AB1 in vitro . Lacks inherent specificity for any particular lysine residue of ubiquitin . Essential for viral activation of IRF3 . Mediates polyubiquitination of CYP3A4 .<BOP>
P51668
Q96LB8
PGRP4_HUMAN
Peptidoglycan recognition protein intermediate beta
Homo
<M><L><P><W><L><L><V><F><S><A><L><G><I><Q><A><W><G><D><S><S><W><N><K><T><Q><A><K><Q><V><S><E><G><L><Q><Y><L><F><E><N><I><S><Q><L><T><E><K><G><L><P><T><D><V><S><T><T><V><S><R><K><A><W><G><A><E><A><V><G><C><S><I><Q><L><T><T><P><V><N><V><L><V><I><H><H><V><P><G><L><E><C><H><D><Q><T><V><C><S><Q><R><L><R><E><L><Q><A><H><H><V><H><N><N><S><G><C><D><V><A><Y><N><F><L><V><G><D><D><G><R><V><Y><E><G><V><G><W><N><I><Q><G><V><H><T><Q><G><Y><N><N><I><S><L><G><F><A><F><F><G><T><K><K><G><H><S><P><S><P><A><A><L><S><A><M><E><N><L><I><T><Y><A><V><Q><K><G><H><L><S><S><S><Y><V><Q><P><L><L><G><K><G><E><N><C><L><A><P><R><Q><K><T><S><L><K><K><A><C><P><G><V><V><P><R><S><V><W><G><A><R><E><T><H><C><P><R><M><T><L><P><A><K><Y><G><I><I><I><H><T><A><G><R><T><C><N><I><S><D><E><C><R><L><L><V><R><D><I><Q><S><F><Y><I><D><R><L><K><S><C><D><I><G><Y><N><F><L><V><G><Q><D><G><A><I><Y><E><G><V><G><W><N><V><Q><G><S><S><T><P><G><Y><D><D><I><A><L><G><I><T><F><M><G><T><F><T><G><I><P><P><N><A><A><A><L><E><A><A><Q><D><L><I><Q><C><A><M><V><K><G><Y><L><T><P><N><Y><L><L><V><G><H><S><D><V><A><R><T><L><S><P><G><Q><A><L><Y><N><I><I><S><T><W><P><H><F><K><H>
Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.<BOP>
Q96LB8
Q8N1E6
FXL14_HUMAN
F-box and leucine-rich repeat protein 14
Homo
<M><E><T><H><I><S><C><L><F><P><E><L><L><A><M><I><F><G><Y><L><D><V><R><D><K><G><R><A><A><Q><V><C><T><A><W><R><D><A><A><Y><H><K><S><V><W><R><G><V><E><A><K><L><H><L><R><R><A><N><P><S><L><F><P><S><L><Q><A><R><G><I><R><R><V><Q><I><L><S><L><R><R><S><L><S><Y><V><I><Q><G><M><A><N><I><E><S><L><N><L><S><G><C><Y><N><L><T><D><N><G><L><G><H><A><F><V><Q><E><I><G><S><L><R><A><L><N><L><S><L><C><K><Q><I><T><D><S><S><L><G><R><I><A><Q><Y><L><K><G><L><E><V><L><E><L><G><G><C><S><N><I><T><N><T><G><L><L><L><I><A><W><G><L><Q><R><L><K><S><L><N><L><R><S><C><R><H><L><S><D><V><G><I><G><H><L><A><G><M><T><R><S><A><A><E><G><C><L><G><L><E><Q><L><T><L><Q><D><C><Q><K><L><T><D><L><S><L><K><H><I><S><R><G><L><T><G><L><R><L><L><N><L><S><F><C><G><G><I><S><D><A><G><L><L><H><L><S><H><M><G><S><L><R><S><L><N><L><R><S><C><D><N><I><S><D><T><G><I><M><H><L><A><M><G><S><L><R><L><S><G><L><D><V><S><F><C><D><K><V><G><D><Q><S><L><A><Y><I><A><Q><G><L><D><G><L><K><S><L><S><L><C><S><C><H><I><S><D><D><G><I><N><R><M><V><R><Q><M><H><G><L><R><T><L><N><I><G><Q><C><V><R><I><T><D><K><G><L><E><L><I><A><E><H><L><S><Q><L><T><G><I><D><L><Y><G><C><T><R><I><T><K><R><G><L><E><R><I><T><Q><L><P><C><L><K><V><L><N><L><G><L><W><Q><M><T><D><S><E><K><E><A><R><G><D><F><S><P><L><F><T><V><R><T><R><G><S><S><R><R>
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.<BOP>
Q8N1E6
Q5VWZ2
LYPL1_HUMAN
Lysophospholipase-like protein 1
Homo
<M><A><A><A><S><G><S><V><L><Q><R><C><I><V><S><P><A><G><R><H><S><A><S><L><I><F><L><H><G><S><G><D><S><G><Q><G><L><R><M><W><I><K><Q><V><L><N><Q><D><L><T><F><Q><H><I><K><I><I><Y><P><T><A><P><P><R><S><Y><T><P><M><K><G><G><I><S><N><V><W><F><D><R><F><K><I><T><N><D><C><P><E><H><L><E><S><I><D><V><M><C><Q><V><L><T><D><L><I><D><E><E><V><K><S><G><I><K><K><N><R><I><L><I><G><G><F><S><M><G><G><C><M><A><I><H><L><A><Y><R><N><H><Q><D><V><A><G><V><F><A><L><S><S><F><L><N><K><A><S><A><V><Y><Q><A><L><Q><K><S><N><G><V><L><P><E><L><F><Q><C><H><G><T><A><D><E><L><V><L><H><S><W><A><E><E><T><N><S><M><L><K><S><L><G><V><T><T><K><F><H><S><F><P><N><V><Y><H><E><L><S><K><T><E><L><D><I><L><K><L><W><I><L><T><K><L><P><G><E><M><E><K><Q><K>
Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.<BOP>
Q5VWZ2
Q92185
SIA8A_HUMAN
Sialyltransferase St8Sia I
Homo
<M><S><P><C><G><R><A><R><R><Q><T><S><R><G><A><M><A><V><L><A><W><K><F><P><R><T><R><L><P><M><G><A><S><A><L><C><V><V><V><L><C><W><L><Y><I><F><P><V><Y><R><L><P><N><E><K><E><I><V><Q><G><V><L><Q><Q><G><T><A><W><R><R><N><Q><T><A><A><R><A><F><R><K><Q><M><E><D><C><C><D><P><A><H><L><F><A><M><T><K><M><N><S><P><M><G><K><S><M><W><Y><D><G><E><F><L><Y><S><F><T><I><D><N><S><T><Y><S><L><F><P><Q><A><T><P><F><Q><L><P><L><K><K><C><A><V><V><G><N><G><G><I><L><K><K><S><G><C><G><R><Q><I><D><E><A><N><F><V><M><R><C><N><L><P><P><L><S><S><E><Y><T><K><D><V><G><S><K><S><Q><L><V><T><A><N><P><S><I><I><R><Q><R><F><Q><N><L><L><W><S><R><K><T><F><V><D><N><M><K><I><Y><N><H><S><Y><I><Y><M><P><A><F><S><M><K><T><G><T><E><P><S><L><R><V><Y><Y><T><L><S><D><V><G><A><N><Q><T><V><L><F><A><N><P><N><F><L><R><S><I><G><K><F><W><K><S><R><G><I><H><A><K><R><L><S><T><G><L><F><L><V><S><A><A><L><G><L><C><E><E><V><A><I><Y><G><F><W><P><F><S><V><N><M><H><E><Q><P><I><S><H><H><Y><Y><D><N><V><L><P><F><S><G><F><H><A><M><P><E><E><F><L><Q><L><W><Y><L><H><K><I><G><A><L><R><M><Q><L><D><P><C><E><D><T><S><L><Q><P><T><S>
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid . Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3 . Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively . Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells .<BOP>
Q92185
O95436
NPT2B_HUMAN
Solute carrier family 34 member 2
Homo
<M><A><P><W><P><E><L><G><D><A><Q><P><N><P><D><K><Y><L><E><G><A><A><G><Q><Q><P><T><A><P><D><K><S><K><E><T><N><K><T><D><N><T><E><A><P><V><T><K><I><E><L><L><P><S><Y><S><T><A><T><L><I><D><E><P><T><E><V><D><D><P><W><N><L><P><T><L><Q><D><S><G><I><K><W><S><E><R><D><T><K><G><K><I><L><C><F><F><Q><G><I><G><R><L><I><L><L><L><G><F><L><Y><F><F><V><C><S><L><D><I><L><S><S><A><F><Q><L><V><G><G><K><M><A><G><Q><F><F><S><N><S><S><I><M><S><N><P><L><L><G><L><V><I><G><V><L><V><T><V><L><V><Q><S><S><S><T><S><T><S><I><V><V><S><M><V><S><S><S><L><L><T><V><R><A><A><I><P><I><I><M><G><A><N><I><G><T><S><I><T><N><T><I><V><A><L><M><Q><V><G><D><R><S><E><F><R><R><A><F><A><G><A><T><V><H><D><F><F><N><W><L><S><V><L><V><L><L><P><V><E><V><A><T><H><Y><L><E><I><I><T><Q><L><I><V><E><S><F><H><F><K><N><G><E><D><A><P><D><L><L><K><V><I><T><K><P><F><T><K><L><I><V><Q><L><D><K><K><V><I><S><Q><I><A><M><N><D><E><K><A><K><N><K><S><L><V><K><I><W><C><K><T><F><T><N><K><T><Q><I><N><V><T><V><P><S><T><A><N><C><T><S><P><S><L><C><W><T><D><G><I><Q><N><W><T><M><K><N><V><T><Y><K><E><N><I><A><K><C><Q><H><I><F><V><N><F><H><L><P><D><L><A><V><G><T><I><L><L><I><L><S><L><L><V><L><C><G><C><L><I><M><I><V><K><I><L><G><S><V><L><K><G><Q><V><A><T><V><I><K><K><T><I><N><T><D><F><P><F><P><F><A><W><L><T><G><Y><L><A><I><L><V><G><A><G><M><T><F><I><V><Q><S><S><S><V><F><T><S><A><L><T><P><L><I><G><I><G><V><I><T><I><E><R><A><Y><P><L><T><L><G><S><N><I><G><T><T><T><T><A><I><L><A><A><L><A><S><P><G><N><A><L><R><S><S><L><Q><I><A><L><C><H><F><F><F><N><I><S><G><I><L><L><W><Y><P><I><P><F><T><R><L><P><I><R><M><A><K><G><L><G><N><I><S><A><K><Y><R><W><F><A><V><F><Y><L><I><I><F><F><F><L><I><P><L><T><V><F><G><L><S><L><A><G><W><R><V><L><V><G><V><G><V><P><V><V><F><I><I><I><L><V><L><C><L><R><L><L><Q><S><R><C><P><R><V><L><P><K><K><L><Q><N><W><N><F><L><P><L><W><M><R><S><L><K><P><W><D><A><V><V><S><K><F><T><G><C><F><Q><M><R><C><C><C><C><C><R><V><C><C><R><A><C><C><L><L><C><D><C><P><K><C><C><R><C><S><K><C><C><E><D><L><E><E><A><Q><E><G><Q><D><V><P><V><K><A><P><E><T><F><D><N><I><T><I><S><R><E><A><Q><G><E><V><P><A><S><D><S><K><T><E><C><T><A><L>
Involved in actively transporting phosphate into cells via Na(+) cotransport.<BOP>
O95436
Q8NGT2
O13J1_HUMAN
Olfactory receptor OR9-2
Homo
<M><E><P><L><N><R><T><E><V><S><E><F><F><L><K><G><F><S><G><Y><P><A><L><E><H><L><L><F><P><L><C><S><A><M><Y><L><V><T><L><L><G><N><T><A><I><M><A><V><S><V><L><D><I><H><L><H><T><P><V><Y><F><F><L><G><N><L><S><T><L><D><I><C><Y><T><P><T><F><V><P><L><M><L><V><H><L><L><S><S><R><K><T><I><S><F><A><V><C><A><I><Q><M><C><L><S><L><S><T><G><S><T><E><C><L><L><L><A><I><T><A><Y><D><R><Y><L><A><I><C><Q><P><L><R><Y><H><V><L><M><S><H><R><L><C><V><L><L><M><G><A><A><W><V><L><C><L><L><K><S><V><T><E><M><V><I><S><M><R><L><P><F><C><G><H><H><V><V><S><H><F><T><C><K><I><L><A><V><L><K><L><A><C><G><N><T><S><V><S><E><D><F><L><L><A><G><S><I><L><L><L><P><V><P><L><A><F><I><C><L><S><Y><L><L><I><L><A><T><I><L><R><V><P><S><A><A><R><C><C><K><A><F><S><T><C><L><A><H><L><A><V><V><L><L><F><Y><G><T><I><I><F><M><Y><L><K><P><K><S><K><E><A><H><I><S><D><E><V><F><T><V><L><Y><A><M><V><T><T><M><L><N><P><T><I><Y><S><L><R><N><K><E><V><K><E><A><A><R><K><V><W><G><R><S><R><A><S><R>
Odorant receptor.<BOP>
Q8NGT2
Q9UMR3
TBX20_HUMAN
T-box transcription factor TBX20
Homo
<M><E><F><T><A><S><P><K><P><Q><L><S><S><R><A><N><A><F><S><I><A><A><L><M><S><S><G><G><S><K><E><K><E><A><T><E><N><T><I><K><P><L><E><Q><F><V><E><K><S><S><C><A><Q><P><L><G><E><L><T><S><L><D><A><H><G><E><F><G><G><G><S><G><S><S><P><S><S><S><S><L><C><T><E><P><L><I><P><T><T><P><I><I><P><S><E><E><M><A><K><I><A><C><S><L><E><T><K><E><L><W><D><K><F><H><E><L><G><T><E><M><I><I><T><K><S><G><R><R><M><F><P><T><I><R><V><S><F><S><G><V><D><P><E><A><K><Y><I><V><L><M><D><I><V><P><V><D><N><K><R><Y><R><Y><A><Y><H><R><S><S><W><L><V><A><G><K><A><D><P><P><L><P><A><R><L><Y><V><H><P><D><S><P><F><T><G><E><Q><L><L><K><Q><M><V><S><F><E><K><V><K><L><T><N><N><E><L><D><Q><H><G><H><I><I><L><N><S><M><H><K><Y><Q><P><R><V><H><I><I><K><K><K><D><H><T><A><S><L><L><N><L><K><S><E><E><F><R><T><F><I><F><P><E><T><V><F><T><A><V><T><A><Y><Q><N><Q><L><I><T><K><L><K><I><D><S><N><P><F><A><K><G><F><R><D><S><S><R><L><T><D><I><E><R><E><S><V><E><S><L><I><Q><K><H><S><Y><A><R><S><P><I><R><T><Y><G><G><E><E><D><V><L><G><D><E><S><Q><T><T><P><N><R><G><S><A><F><T><T><S><D><N><L><S><L><S><S><W><V><S><S><S><S><S><F><P><G><F><Q><H><P><Q><S><L><T><A><L><G><T><S><T><A><S><I><A><T><P><I><P><H><P><I><Q><G><S><L><P><P><Y><S><R><L><G><M><P><L><T><P><S><A><I><A><S><S><M><Q><G><S><G><P><T><F><P><S><F><H><M><P><R><Y><H><H><Y><F><Q><Q><G><P><Y><A><A><I><Q><G><L><R><H><S><S><A><V><M><T><P><F><V>
Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart.<BOP>
Q9UMR3
O95718
ERR2_HUMAN
Nuclear receptor subfamily 3 group B member 2
Homo
<M><S><S><D><D><R><H><L><G><S><S><C><G><S><F><I><K><T><E><P><S><S><P><S><S><G><I><D><A><L><S><H><H><S><P><S><G><S><S><D><A><S><G><G><F><G><L><A><L><G><T><H><A><N><G><L><D><S><P><P><M><F><A><G><A><G><L><G><G><T><P><C><R><K><S><Y><E><D><C><A><S><G><I><M><E><D><S><A><I><K><C><E><Y><M><L><N><A><I><P><K><R><L><C><L><V><C><G><D><I><A><S><G><Y><H><Y><G><V><A><S><C><E><A><C><K><A><F><F><K><R><T><I><Q><G><N><I><E><Y><S><C><P><A><T><N><E><C><E><I><T><K><R><R><R><K><S><C><Q><A><C><R><F><M><K><C><L><K><V><G><M><L><K><E><G><V><R><L><D><R><V><R><G><G><R><Q><K><Y><K><R><R><L><D><S><E><S><S><P><Y><L><S><L><Q><I><S><P><P><A><K><K><P><L><T><K><I><V><S><Y><L><L><V><A><E><P><D><K><L><Y><A><M><P><P><P><G><M><P><E><G><D><I><K><A><L><T><T><L><C><D><L><A><D><R><E><L><V><V><I><I><G><W><A><K><H><I><P><G><F><S><S><L><S><L><G><D><Q><M><S><L><L><Q><S><A><W><M><E><I><L><I><L><G><I><V><Y><R><S><L><P><Y><D><D><K><L><V><Y><A><E><D><Y><I><M><D><E><E><H><S><R><L><A><G><L><L><E><L><Y><R><A><I><L><Q><L><V><R><R><Y><K><K><L><K><V><E><K><E><E><F><V><T><L><K><A><L><A><L><A><N><S><D><S><M><Y><I><E><D><L><E><A><V><Q><K><L><Q><D><L><L><H><E><A><L><Q><D><Y><E><L><S><Q><R><H><E><E><P><W><R><T><G><K><L><L><L><T><L><P><L><L><R><Q><T><A><A><K><A><V><Q><H><F><Y><S><V><K><L><Q><G><K><V><P><M><H><K><L><F><L><E><M><L><E><A><K><V>
Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.<BOP>
O95718
A0A0C4DH72
KV106_HUMAN
Immunoglobulin kappa variable 1-6
Homo
<M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><P><G><A><R><C><A><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><R><N><D><L><G><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><A><A><S><S><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><F><A><T><Y><Y><C><L><Q><D><Y><N><Y><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0C4DH72
Q06547
GABP1_HUMAN
Transcription factor E4TF1-53
Homo
<M><S><L><V><D><L><G><K><K><L><L><E><A><A><R><A><G><Q><D><D><E><V><R><I><L><M><A><N><G><A><P><F><T><T><D><W><L><G><T><S><P><L><H><L><A><A><Q><Y><G><H><Y><S><T><T><E><V><L><L><R><A><G><V><S><R><D><A><R><T><K><V><D><R><T><P><L><H><M><A><A><S><E><G><H><A><S><I><V><E><V><L><L><K><H><G><A><D><V><N><A><K><D><M><L><K><M><T><A><L><H><W><A><T><E><H><N><H><Q><E><V><V><E><L><L><I><K><Y><G><A><D><V><H><T><Q><S><K><F><C><K><T><A><F><D><I><S><I><D><N><G><N><E><D><L><A><E><I><L><Q><I><A><M><Q><N><Q><I><N><T><N><P><E><S><P><D><T><V><T><I><H><A><A><T><P><Q><F><I><I><G><P><G><G><V><V><N><L><T><G><L><V><S><S><E><N><S><S><K><A><T><D><E><T><G><V><S><A><V><Q><F><G><N><S><S><T><S><V><L><A><T><L><A><A><L><A><E><A><S><A><P><L><S><N><S><S><E><T><P><V><V><A><T><E><E><V><V><T><A><E><S><V><D><G><A><I><Q><Q><V><V><S><S><G><G><Q><Q><V><I><T><I><V><T><D><G><I><Q><L><G><N><L><H><S><I><P><T><S><G><I><G><Q><P><I><I><V><T><M><P><D><G><Q><Q><V><L><T><V><P><A><T><D><I><A><E><E><T><V><I><S><E><E><P><P><A><K><R><Q><C><I><E><I><I><E><N><R><V><E><S><A><E><I><E><E><R><E><A><L><Q><K><Q><L><D><E><A><N><R><E><A><Q><K><Y><R><Q><Q><L><L><K><K><E><Q><E><A><E><A><Y><R><Q><K><L><E><A><M><T><R><L><Q><T><N><K><E><A><V>
(Microbial infection) Necessary for the expression of the Adenovirus E4 gene.<BOP>
Q06547
Q9UHR6
ZNHI2_HUMAN
Protein FON
Homo
<M><E><P><A><G><P><C><G><F><C><P><A><G><E><V><Q><P><A><R><Y><T><C><P><R><C><N><A><P><Y><C><S><L><R><C><Y><R><T><H><G><T><C><A><E><N><F><Y><R><D><Q><V><L><G><E><L><R><G><C><S><A><P><P><S><R><L><A><S><A><L><R><R><L><R><Q><Q><R><E><T><E><D><E><P><G><E><A><G><L><S><S><G><P><A><P><G><G><L><S><G><L><W><E><R><L><A><P><G><E><K><A><A><F><E><R><L><L><S><R><G><E><A><G><R><L><L><P><P><W><R><P><W><W><W><N><R><G><A><G><P><Q><L><L><E><E><L><D><N><A><P><G><S><D><A><A><E><L><E><L><A><P><A><R><T><P><P><D><S><V><K><D><A><S><A><A><E><P><A><A><A><E><R><V><L><G><D><V><P><G><A><C><T><P><V><V><P><T><R><I><P><A><I><V><S><L><S><R><G><P><V><S><P><L><V><R><F><Q><L><P><N><V><L><F><A><Y><A><H><T><L><A><L><Y><H><G><G><D><D><A><L><L><S><D><F><C><A><T><L><L><G><V><S><G><A><L><G><A><Q><Q><V><F><A><S><A><E><E><A><L><Q><A><A><A><H><V><L><E><A><G><E><H><P><P><G><P><L><G><T><R><G><A><M><H><E><V><A><R><I><L><L><G><E><G><P><T><N><Q><K><G><Y><T><L><A><A><L><G><D><L><A><Q><T><L><G><R><A><R><K><Q><A><V><A><R><E><E><R><D><H><L><Y><R><A><R><K><K><C><Q><F><L><L><A><W><T><N><E><N><E><A><A><L><T><P><L><A><L><D><C><A><R><A><H><Q><A><H><A><V><V><A><E><E><V><A><A><L><T><G><E><L><E><R><L><W><G><G><P><V><P><P><A><P><R><T><L><I><E><E><L><P><S>
May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) . Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 . May play a role in regulating the composition of the U5 snRNP complex .<BOP>
Q9UHR6
Q14119
VEZF1_HUMAN
Zinc finger protein 161
Homo
<M><E><A><N><W><T><A><F><L><F><Q><A><H><E><A><S><H><H><Q><Q><Q><A><A><Q><N><S><L><L><P><L><L><S><S><A><V><E><P><P><D><Q><K><P><L><L><P><I><P><I><T><Q><K><P><Q><G><A><P><E><T><L><K><D><A><I><G><I><K><K><E><K><P><K><T><S><F><V><C><T><Y><C><S><K><A><F><R><D><S><Y><H><L><R><R><H><E><S><C><H><T><G><I><K><L><V><S><R><P><K><K><T><P><T><T><V><V><P><L><I><S><T><I><A><G><D><S><S><R><T><S><L><V><S><T><I><A><G><I><L><S><T><V><T><T><S><S><S><G><T><N><P><S><S><S><A><S><T><T><A><M><P><V><T><Q><S><V><K><K><P><S><K><P><V><K><K><N><H><A><C><E><M><C><G><K><A><F><R><D><V><Y><H><L><N><R><H><K><L><S><H><S><D><E><K><P><F><E><C><P><I><C><N><Q><R><F><K><R><K><D><R><M><T><Y><H><V><R><S><H><E><G><G><I><T><K><P><Y><T><C><S><V><C><G><K><G><F><S><R><P><D><H><L><S><C><H><V><K><H><V><H><S><T><E><R><P><F><K><C><Q><T><C><T><A><A><F><A><T><K><D><R><L><R><T><H><M><V><R><H><E><G><K><V><S><C><N><I><C><G><K><L><L><S><A><A><Y><I><T><S><H><L><K><T><H><G><Q><S><Q><S><I><N><C><N><T><C><K><Q><G><I><S><K><T><C><M><S><E><E><T><S><N><Q><K><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><H><V><T><S><W><P><G><K><Q><V><E><T><L><R><L><W><E><E><A><V><K><A><R><K><K><E><A><A><N><L><C><Q><T><S><T><A><A><T><T><P><V><T><L><T><T><P><F><S><I><T><S><S><V><S><S><G><T><M><S><N><P><V><T><V><A><A><A><M><S><M><R><S><P><V><N><V><S><S><A><V><N><I><T><S><P><M><N><I><G><H><P><V><T><I><T><S><P><L><S><M><T><S><P><L><T><L><T><T><P><V><N><L><P><T><P><V><T><A><P><V><N><I><A><H><P><V><T><I><T><S><P><M><N><L><P><T><P><M><T><L><A><A><P><L><N><I><A><M><R><P><V><E><S><M><P><F><L><P><Q><A><L><P><T><S><P><P><W>
Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.<BOP>
Q14119
Q96NI6
LRFN5_HUMAN
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Homo
<M><E><K><I><L><F><Y><L><F><L><I><G><I><A><V><K><A><Q><I><C><P><K><R><C><V><C><Q><I><L><S><P><N><L><A><T><L><C><A><K><K><G><L><L><F><V><P><P><N><I><D><R><R><T><V><E><L><R><L><A><D><N><F><V><T><N><I><K><R><K><D><F><A><N><M><T><S><L><V><D><L><T><L><S><R><N><T><I><S><F><I><T><P><H><A><F><A><D><L><R><N><L><R><A><L><H><L><N><S><N><R><L><T><K><I><T><N><D><M><F><S><G><L><S><N><L><H><H><L><I><L><N><N><N><Q><L><T><L><I><S><S><T><A><F><D><D><V><F><A><L><E><E><L><D><L><S><Y><N><N><L><E><T><I><P><W><D><A><V><E><K><M><V><S><L><H><T><L><S><L><D><H><N><M><I><D><N><I><P><K><G><T><F><S><H><L><H><K><M><T><R><L><D><V><T><S><N><K><L><Q><K><L><P><P><D><P><L><F><Q><R><A><Q><V><L><A><T><S><G><I><I><S><P><S><T><F><A><L><S><F><G><G><N><P><L><H><C><N><C><E><L><L><W><L><R><R><L><S><R><E><D><D><L><E><T><C><A><S><P><P><L><L><T><G><R><Y><F><W><S><I><P><E><E><E><F><L><C><E><P><P><L><I><T><R><H><T><H><E><M><R><V><L><E><G><Q><R><A><T><L><R><C><K><A><R><G><D><P><E><P><A><I><H><W><I><S><P><E><G><K><L><I><S><N><A><T><R><S><L><V><Y><D><N><G><T><L><D><I><L><I><T><T><V><K><D><T><G><A><F><T><C><I><A><S><N><P><A><G><E><A><T><Q><I><V><D><L><H><I><I><K><L><P><H><L><L><N><S><T><N><H><I><H><E><P><D><P><G><S><S><D><I><S><T><S><T><K><S><G><S><N><T><S><S><S><N><G><D><T><K><L><S><Q><D><K><I><V><V><A><E><A><T><S><S><T><A><L><L><K><F><N><F><Q><R><N><I><P><G><I><R><M><F><Q><I><Q><Y><N><G><T><Y><D><D><T><L><V><Y><R><M><I><P><P><T><S><K><T><F><L><V><N><N><L><A><A><G><T><M><Y><D><L><C><V><L><A><I><Y><D><D><G><I><T><S><L><T><A><T><R><V><V><G><C><I><Q><F><T><T><E><Q><D><Y><V><R><C><H><F><M><Q><S><Q><F><L><G><G><T><M><I><I><I><I><G><G><I><I><V><A><S><V><L><V><F><I><I><I><L><M><I><R><Y><K><V><C><N><N><N><G><Q><H><K><V><T><K><V><S><N><V><Y><S><Q><T><N><G><A><Q><I><Q><G><C><S><V><T><L><P><Q><S><V><S><K><Q><A><V><G><H><E><E><N><A><Q><C><C><K><A><T><S><D><N><V><I><Q><S><S><E><T><C><S><S><Q><D><S><S><T><T><T><S><A><L><P><P><S><W><T><S><S><T><S><V><S><Q><K><Q><K><R><K><T><G><T><K><P><S><T><E><P><Q><N><E><A><V><T><N><V><E><S><Q><N><T><N><R><N><N><S><T><A><L><Q><L><A><S><R><P><P><D><S><V><T><E><G><P><T><S><K><R><A><H><I><K><P><N><A><L><L><T><N><V><D><Q><I><V><Q><E><T><Q><R><L><E><L><I>
Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.<BOP>
Q96NI6
Q0WX57
U17LO_HUMAN
Ubiquitin-specific-processing protease 17
Homo
<M><E><D><D><S><L><Y><L><R><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><P><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><S><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
Q0WX57
Q9NPH5
NOX4_HUMAN
Renal NAD(P)H-oxidase
Homo
<M><A><V><S><W><R><S><W><L><A><N><E><G><V><K><H><L><C><L><F><I><W><L><S><M><N><V><L><L><F><W><K><T><F><L><L><Y><N><Q><G><P><E><Y><H><Y><L><H><Q><M><L><G><L><G><L><C><L><S><R><A><S><A><S><V><L><N><L><N><C><S><L><I><L><L><P><M><C><R><T><L><L><A><Y><L><R><G><S><Q><K><V><P><S><R><R><T><R><R><L><L><D><K><S><R><T><F><H><I><T><C><G><V><T><I><C><I><F><S><G><V><H><V><A><A><H><L><V><N><A><L><N><F><S><V><N><Y><S><E><D><F><V><E><L><N><A><A><R><Y><R><D><E><D><P><R><K><L><L><F><T><T><V><P><G><L><T><G><V><C><M><V><V><V><L><F><L><M><I><T><A><S><T><Y><A><I><R><V><S><N><Y><D><I><F><W><Y><T><H><N><L><F><F><V><F><Y><M><L><L><T><L><H><V><S><G><G><L><L><K><Y><Q><T><N><L><D><T><H><P><P><G><C><I><S><L><N><R><T><S><S><Q><N><I><S><L><P><E><Y><F><S><E><H><F><H><E><P><F><P><E><G><F><S><K><P><A><E><F><T><Q><H><K><F><V><K><I><C><M><E><E><P><R><F><Q><A><N><F><P><Q><T><W><L><W><I><S><G><P><L><C><L><Y><C><A><E><R><L><Y><R><Y><I><R><S><N><K><P><V><T><I><I><S><V><M><S><H><P><S><D><V><M><E><I><R><M><V><K><E><N><F><K><A><R><P><G><Q><Y><I><T><L><H><C><P><S><V><S><A><L><E><N><H><P><F><T><L><T><M><C><P><T><E><T><K><A><T><F><G><V><H><L><K><I><V><G><D><W><T><E><R><F><R><D><L><L><L><P><P><S><S><Q><D><S><E><I><L><P><F><I><Q><S><R><N><Y><P><K><L><Y><I><D><G><P><F><G><S><P><F><E><E><S><L><N><Y><E><V><S><L><C><V><A><G><G><I><G><V><T><P><F><A><S><I><L><N><T><L><L><D><D><W><K><P><Y><K><L><R><R><L><Y><F><I><W><V><C><R><D><I><Q><S><F><R><W><F><A><D><L><L><C><M><L><H><N><K><F><W><Q><E><N><R><P><D><Y><V><N><I><Q><L><Y><L><S><Q><T><D><G><I><Q><K><I><I><G><E><K><Y><H><A><L><N><S><R><L><F><I><G><R><P><R><W><K><L><L><F><D><E><I><A><K><Y><N><R><G><K><T><V><G><V><F><C><C><G><P><N><S><L><S><K><T><L><H><K><L><S><N><Q><N><N><S><Y><G><T><R><F><E><Y><N><K><E><S><F><S>
Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.<BOP>
Q9NPH5
Q8N1D5
CF107_HUMAN
Cilia- and flagella-associated protein 107
Homo
<M><F><L><T><A><V><N><P><Q><P><L><S><T><P><S><W><Q><I><E><T><K><Y><S><T><K><V><L><T><G><N><W><M><E><E><R><R><K><F><T><R><D><T><D><K><T><P><Q><S><I><Y><R><K><E><Y><I><P><F><P><D><H><R><P><D><Q><I><S><R><W><Y><G><K><R><K><V><E><G><L><P><Y><K><H><L><I><T><H><H><Q><E><P><P><H><R><Y><L><I><S><T><Y><D><D><H><Y><N><R><H><G><Y><N><P><G><L><P><P><L><R><T><W><N><G><Q><K><L><L><W><L><P><E><K><S><D><F><P><L><L><A><P><P><T><N><Y><G><L><Y><E><Q><L><K><Q><R><Q><L><T><P><K><A><G><L><K><Q><S><T><Y><T><S><S><Y><P><R><P><P><L><C><A><M><S><W><R><E><H><A><V><P><V><P><P><H><R><L><H><P><L><P><H><F>
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP>
Q8N1D5
Q7L592
NDUF7_HUMAN
Protein midA homolog
Homo
<M><S><V><L><L><R><S><G><L><G><P><L><C><A><V><A><R><A><A><I><P><F><I><W><R><G><K><Y><F><S><S><G><N><E><P><A><E><N><P><V><T><P><M><L><R><H><L><M><Y><K><I><K><S><T><G><P><I><T><V><A><E><Y><M><K><E><V><L><T><N><P><A><K><G><Y><Y><V><Y><R><D><M><L><G><E><K><G><D><F><I><T><S><P><E><I><S><Q><I><F><G><E><L><L><G><I><W><F><I><S><E><W><M><A><T><G><K><S><T><A><F><Q><L><V><E><L><G><P><G><R><G><T><L><V><G><D><I><L><R><V><F><T><Q><L><G><S><V><L><K><N><C><D><I><S><V><H><L><V><E><V><S><Q><K><L><S><E><I><Q><A><L><T><L><T><K><E><K><V><P><L><E><R><N><A><G><S><P><V><Y><M><K><G><V><T><K><S><G><I><P><I><S><W><Y><R><D><L><H><D><V><P><K><G><Y><S><F><Y><L><A><H><E><F><F><D><V><L><P><V><H><K><F><Q><K><T><P><Q><G><W><R><E><V><F><V><D><I><D><P><Q><V><S><D><K><L><R><F><V><L><A><P><S><A><T><P><A><E><A><F><I><Q><H><D><E><T><R><D><H><V><E><V><C><P><D><A><G><V><I><I><E><E><L><S><Q><R><I><A><L><T><G><G><A><A><L><V><A><D><Y><G><H><D><G><T><K><T><D><T><F><R><G><F><C><D><H><K><L><H><D><V><L><I><A><P><G><T><A><D><L><T><A><D><V><D><F><S><Y><L><R><R><M><A><Q><G><K><V><A><S><L><G><P><I><K><Q><H><T><F><L><K><N><M><G><I><D><V><R><L><K><V><L><L><D><K><S><N><E><P><S><V><R><Q><Q><L><L><Q><G><Y><D><M><L><M><N><P><K><K><M><G><E><R><F><N><F><F><A><L><L><P><H><Q><R><L><Q><G><G><R><Y><Q><R><N><A><R><Q><S><K><P><F><A><S><V><V><A><G><F><S><E><L><A><W><Q>
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) . Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex .<BOP>
Q7L592
O60784
TOM1_HUMAN
Target of Myb protein 1
Homo
<M><D><F><L><L><G><N><P><F><S><S><P><V><G><Q><R><I><E><K><A><T><D><G><S><L><Q><S><E><D><W><A><L><N><M><E><I><C><D><I><I><N><E><T><E><E><G><P><K><D><A><L><R><A><V><K><K><R><I><V><G><N><K><N><F><H><E><V><M><L><A><L><T><V><L><E><T><C><V><K><N><C><G><H><R><F><H><V><L><V><A><S><Q><D><F><V><E><S><V><L><V><R><T><I><L><P><K><N><N><P><P><T><I><V><H><D><K><V><L><N><L><I><Q><S><W><A><D><A><F><R><S><S><P><D><L><T><G><V><V><T><I><Y><E><D><L><R><R><K><G><L><E><F><P><M><T><D><L><D><M><L><S><P><I><H><T><P><Q><R><T><V><F><N><S><E><T><Q><S><G><Q><D><S><V><G><T><D><S><S><Q><Q><E><D><S><G><Q><H><A><A><P><L><P><A><P><P><I><L><S><G><D><T><P><I><A><P><T><P><E><Q><I><G><K><L><R><S><E><L><E><M><V><S><G><N><V><R><V><M><S><E><M><L><T><E><L><V><P><T><Q><A><E><P><A><D><L><E><L><L><Q><E><L><N><R><T><C><R><A><M><Q><Q><R><V><L><E><L><I><P><Q><I><A><N><E><Q><L><T><E><E><L><L><I><V><N><D><N><L><N><N><V><F><L><R><H><E><R><F><E><R><F><R><T><G><Q><T><T><K><A><P><S><E><A><E><P><A><A><D><L><I><D><M><G><P><D><P><A><A><T><G><N><L><S><S><Q><L><A><G><M><N><L><G><S><S><S><V><R><A><G><L><Q><S><L><E><A><S><G><R><L><E><D><E><F><D><M><F><A><L><T><R><G><S><S><L><A><D><Q><R><K><E><V><K><Y><E><A><P><Q><A><T><D><G><L><A><G><A><L><D><A><R><Q><Q><S><T><G><A><I><P><V><T><Q><A><C><L><M><E><D><I><E><Q><W><L><S><T><D><V><G><N><D><A><E><E><P><K><G><V><T><S><E><E><F><D><K><F><L><E><E><R><A><K><A><A><D><R><L><P><N><L><S><S><P><S><A><E><G><P><P><G><P><P><S><G><P><A><P><R><K><K><T><Q><E><K><D><D><D><M><L><F><A><L>
Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways . Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures . Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes . MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN . Binds to polyubiquitinated proteins via its GAT domain . In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes . The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin . Mediates clathrin recruitment to early endosomes by ZFYVE16 . Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP
O60784
Q96RP3
UCN2_HUMAN
Urocortin-related peptide
Homo
<M><T><R><C><A><L><L><L><L><M><V><L><M><L><G><R><V><L><V><V><P><V><T><P><I><P><T><F><Q><L><R><P><Q><N><S><P><Q><T><T><P><R><P><A><A><S><E><S><P><S><A><A><P><T><W><P><W><A><A><Q><S><H><C><S><P><T><R><H><P><G><S><R><I><V><L><S><L><D><V><P><I><G><L><L><Q><I><L><L><E><Q><A><R><A><R><A><A><R><E><Q><A><T><T><N><A><R><I><L><A><R><V><G><H><C>
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.<BOP>
Q96RP3
O95998
I18BP_HUMAN
Tadekinig-alfa
Homo
<M><T><M><R><H><N><W><T><P><D><L><S><P><L><W><V><L><L><L><C><A><H><V><V><T><L><L><V><R><A><T><P><V><S><Q><T><T><T><A><A><T><A><S><V><R><S><T><K><D><P><C><P><S><Q><P><P><V><F><P><A><A><K><Q><C><P><A><L><E><V><T><W><P><E><V><E><V><P><L><N><G><T><L><S><L><S><C><V><A><C><S><R><F><P><N><F><S><I><L><Y><W><L><G><N><G><S><F><I><E><H><L><P><G><R><L><W><E><G><S><T><S><R><E><R><G><S><T><G><T><Q><L><C><K><A><L><V><L><E><Q><L><T><P><A><L><H><S><T><N><F><S><C><V><L><V><D><P><E><Q><V><V><Q><R><H><V><V><L><A><Q><L><W><A><G><L><R><A><T><L><P><P><T><Q><E><A><L><P><S><S><H><S><S><P><Q><Q><Q><G>
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.<BOP>
O95998
Q15131
CDK10_HUMAN
Serine/threonine-protein kinase PISSLRE
Homo
<M><A><E><P><D><L><E><C><E><Q><I><R><L><K><C><I><R><K><E><G><F><F><T><V><P><P><E><H><R><L><G><R><C><R><S><V><K><E><F><E><K><L><N><R><I><G><E><G><T><Y><G><I><V><Y><R><A><R><D><T><Q><T><D><E><I><V><A><L><K><K><V><R><M><D><K><E><K><D><G><I><P><I><S><S><L><R><E><I><T><L><L><L><R><L><R><H><P><N><I><V><E><L><K><E><V><V><V><G><N><H><L><E><S><I><F><L><V><M><G><Y><C><E><Q><D><L><A><S><L><L><E><N><M><P><T><P><F><S><E><A><Q><V><K><C><I><V><L><Q><V><L><R><G><L><Q><Y><L><H><R><N><F><I><I><H><R><D><L><K><V><S><N><L><L><M><T><D><K><G><C><V><K><T><A><D><F><G><L><A><R><A><Y><G><V><P><V><K><P><M><T><P><K><V><V><T><L><W><Y><R><A><P><E><L><L><L><G><T><T><T><Q><T><T><S><I><D><M><W><A><V><G><C><I><L><A><E><L><L><A><H><R><P><L><L><P><G><T><S><E><I><H><Q><I><D><L><I><V><Q><L><L><G><T><P><S><E><N><I><W><P><G><F><S><K><L><P><L><V><G><Q><Y><S><L><R><K><Q><P><Y><N><N><L><K><H><K><F><P><W><L><S><E><A><G><L><R><L><L><H><F><L><F><M><Y><D><P><K><K><R><A><T><A><G><D><C><L><E><S><S><Y><F><K><E><K><P><L><P><C><E><P><E><L><M><P><T><F><P><H><H><R><N><K><R><A><A><P><A><T><S><E><G><Q><S><K><R><C><K><P>
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) . Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling .<BOP>
Q15131
Q9BUR4
TCAB1_HUMAN
WD40 repeat-containing protein antisense to TP53 gene
Homo
<M><K><T><L><E><T><Q><P><L><A><P><D><C><C><P><S><D><Q><D><P><A><P><A><H><P><S><P><H><A><S><P><M><N><K><N><A><D><S><E><L><M><P><P><P><P><E><R><G><D><P><P><R><L><S><P><D><P><V><A><G><S><A><V><S><Q><E><L><R><E><G><D><P><V><S><L><S><T><P><L><E><T><E><F><G><S><P><S><E><L><S><P><R><I><E><E><Q><E><L><S><E><N><T><S><L><P><A><E><E><A><N><G><S><L><S><E><E><E><A><N><G><P><E><L><G><S><G><K><A><M><E><D><T><S><G><E><P><A><A><E><D><E><G><D><T><A><W><N><Y><S><F><S><Q><L><P><R><F><L><S><G><S><W><S><E><F><S><T><Q><P><E><N><F><L><K><G><C><K><W><A><P><D><G><S><C><I><L><T><N><S><A><D><N><I><L><R><I><Y><N><L><P><P><E><L><Y><H><E><G><E><Q><V><E><Y><A><E><M><V><P><V><L><R><M><V><E><G><D><T><I><Y><D><Y><C><W><Y><S><L><M><S><S><A><Q><P><D><T><S><Y><V><A><S><S><S><R><E><N><P><I><H><I><W><D><A><F><T><G><E><L><R><A><S><F><R><A><Y><N><H><L><D><E><L><T><A><A><H><S><L><C><F><S><P><D><G><S><Q><L><F><C><G><F><N><R><T><V><R><V><F><S><T><A><R><P><G><R><D><C><E><V><R><A><T><F><A><K><K><Q><G><Q><S><G><I><I><S><C><I><A><F><S><P><A><Q><P><L><Y><A><C><G><S><Y><G><R><S><L><G><L><Y><A><W><D><D><G><S><P><L><A><L><L><G><G><H><Q><G><G><I><T><H><L><C><F><H><P><D><G><N><R><F><F><S><G><A><R><K><D><A><E><L><L><C><W><D><L><R><Q><S><G><Y><P><L><W><S><L><G><R><E><V><T><T><N><Q><R><I><Y><F><D><L><D><P><T><G><Q><F><L><V><S><G><S><T><S><G><A><V><S><V><W><D><T><D><G><P><G><N><D><G><K><P><E><P><V><L><S><F><L><P><Q><K><D><C><T><N><G><V><S><L><H><P><S><L><P><L><L><A><T><A><S><G><Q><R><V><F><P><E><P><T><E><S><G><D><E><G><E><E><L><G><L><P><L><L><S><T><R><H><V><H><L><E><C><R><L><Q><L><W><W><C><G><G><A><P><D><S><S><I><P><D><D><H><Q><G><E><K><G><Q><G><G><T><E><G><G><V><G><E><L><I>
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies . Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) . Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes . In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex . Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity . In addition, also controls telomerase holoenzyme complex localization to Cajal body . During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity . In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies . Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and
Q9BUR4
P11908
PRPS2_HUMAN
Phosphoribosyl pyrophosphate synthase II
Homo
<M><P><N><I><V><L><F><S><G><S><S><H><Q><D><L><S><Q><R><V><A><D><R><L><G><L><E><L><G><K><V><V><T><K><K><F><S><N><Q><E><T><S><V><E><I><G><E><S><V><R><G><E><D><V><Y><I><I><Q><S><G><C><G><E><I><N><D><N><L><M><E><L><L><I><M><I><N><A><C><K><I><A><S><S><S><R><V><T><A><V><I><P><C><F><P><Y><A><R><Q><D><K><K><D><K><S><R><A><P><I><S><A><K><L><V><A><N><M><L><S><V><A><G><A><D><H><I><I><T><M><D><L><H><A><S><Q><I><Q><G><F><F><D><I><P><V><D><N><L><Y><A><E><P><A><V><L><Q><W><I><R><E><N><I><A><E><W><K><N><C><I><I><V><S><P><D><A><G><G><A><K><R><V><T><S><I><A><D><R><L><N><V><E><F><A><L><I><H><K><E><R><K><K><A><N><E><V><D><R><M><V><L><V><G><D><V><K><D><R><V><A><I><L><V><D><D><M><A><D><T><C><G><T><I><C><H><A><A><D><K><L><L><S><A><G><A><T><K><V><Y><A><I><L><T><H><G><I><F><S><G><P><A><I><S><R><I><N><N><A><A><F><E><A><V><V><V><T><N><T><I><P><Q><E><D><K><M><K><H><C><T><K><I><Q><V><I><D><I><S><M><I><L><A><E><A><I><R><R><T><H><N><G><E><S><V><S><Y><L><F><S><H><V><P><L>
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.<BOP>
P11908
Q9NVQ4
FAIM1_HUMAN
Fas apoptotic inhibitory molecule 1
Homo
<M><T><D><L><V><A><V><W><D><V><A><L><S><D><G><V><H><K><I><E><F><E><H><G><T><T><S><G><K><R><V><V><Y><V><D><G><K><E><E><I><R><K><E><W><M><F><K><L><V><G><K><E><T><F><Y><V><G><A><A><K><T><K><A><T><I><N><I><D><A><I><S><G><F><A><Y><E><Y><T><L><E><I><N><G><K><S><L><K><K><Y><M><E><D><R><S><K><T><T><N><T><W><V><L><H><M><D><G><E><N><F><R><I><V><L><E><K><D><A><M><D><V><W><C><N><G><K><K><L><E><T><A><G><E><F><V><D><D><G><T><E><T><H><F><S><I><G><N><H><D><C><Y><I><K><A><V><S><S><G><K><R><K><E><G><I><I><H><T><L><I><V><D><N><R><E><I><P><E><I><A><S>
Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.<BOP>
Q9NVQ4
Q96CG8
CTHR1_HUMAN
Collagen triple helix repeat-containing protein 1
Homo
<M><R><P><Q><G><P><A><A><S><P><Q><R><L><R><G><L><L><L><L><L><L><L><Q><L><P><A><P><S><S><A><S><E><I><P><K><G><K><Q><K><A><Q><L><R><Q><R><E><V><V><D><L><Y><N><G><M><C><L><Q><G><P><A><G><V><P><G><R><D><G><S><P><G><A><N><G><I><P><G><T><P><G><I><P><G><R><D><G><F><K><G><E><K><G><E><C><L><R><E><S><F><E><E><S><W><T><P><N><Y><K><Q><C><S><W><S><S><L><N><Y><G><I><D><L><G><K><I><A><E><C><T><F><T><K><M><R><S><N><S><A><L><R><V><L><F><S><G><S><L><R><L><K><C><R><N><A><C><C><Q><R><W><Y><F><T><F><N><G><A><E><C><S><G><P><L><P><I><E><A><I><I><Y><L><D><Q><G><S><P><E><M><N><S><T><I><N><I><H><R><T><S><S><V><E><G><L><C><E><G><I><G><A><G><L><V><D><V><A><I><W><V><G><T><C><S><D><Y><P><K><G><D><A><S><T><G><W><N><S><V><S><R><I><I><I><E><E><L><P><K>
May act as a negative regulator of collagen matrix deposition.<BOP>
Q96CG8
Q14201
BTG3_HUMAN
Protein Tob5
Homo
<M><K><N><E><I><A><A><V><V><F><F><F><T><R><L><V><R><K><H><D><K><L><K><K><E><A><V><E><R><F><A><E><K><L><T><L><I><L><Q><E><K><Y><K><N><H><W><Y><P><E><K><P><S><K><G><Q><A><Y><R><C><I><R><V><N><K><F><Q><R><V><D><P><D><V><L><K><A><C><E><N><S><C><I><L><Y><S><D><L><G><L><P><K><E><L><T><L><W><V><D><P><C><E><V><C><C><R><Y><G><E><K><N><N><A><F><I><V><A><S><F><E><N><K><D><E><N><K><D><E><I><S><R><K><V><T><R><A><L><D><K><V><T><S><D><Y><H><S><G><S><S><S><S><D><E><E><T><S><K><E><M><E><V><K><P><S><S><V><T><A><A><A><S><P><V><Y><Q><I><S><E><L><I><F><P><P><L><P><M><W><H><P><L><P><R><K><K><P><G><M><Y><R><G><N><G><H><Q><N><H><Y><P><P><P><V><P><F><G><Y><P><N><Q><G><R><K><N><K><P><Y><R><P><I><P><V><T><W><V><P><P><P><G><M><H><C><D><R><N><H><W><I><N><P><H><M><L><A><P><H>
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.<BOP>
Q14201
Q86W42
THOC6_HUMAN
WD repeat-containing protein 58
Homo
<M><E><R><A><V><P><L><A><V><P><L><G><Q><T><E><V><F><Q><A><L><Q><R><L><H><M><T><I><F><S><Q><S><V><S><P><C><G><K><F><L><A><A><G><N><N><Y><G><Q><I><A><I><F><S><L><S><S><A><L><S><S><E><A><K><E><E><S><K><K><P><V><V><T><F><Q><A><H><D><G><P><V><Y><S><M><V><S><T><D><R><H><L><L><S><A><G><D><G><E><V><K><A><W><L><W><A><E><M><L><K><K><G><C><K><E><L><W><R><R><Q><P><P><Y><R><T><S><L><E><V><P><E><I><N><A><L><L><L><V><P><K><E><N><S><L><I><L><A><G><G><D><C><Q><L><H><T><M><D><L><E><T><G><T><F><T><R><V><L><R><G><H><T><D><Y><I><H><C><L><A><L><R><E><R><S><P><E><V><L><S><G><G><E><D><G><A><V><R><L><W><D><L><R><T><A><K><E><V><Q><T><I><E><V><Y><K><H><E><E><C><S><R><P><H><N><G><R><W><I><G><C><L><A><T><D><S><D><W><M><V><C><G><G><G><P><A><L><T><L><W><H><L><R><S><S><T><P><T><T><I><F><P><I><R><A><P><Q><K><H><V><T><F><Y><Q><D><L><I><L><S><A><G><Q><G><R><C><V><N><Q><W><Q><L><S><G><E><L><K><A><Q><V><P><G><S><S><P><G><L><L><S><L><S><L><N><Q><Q><P><A><A><P><E><C><K><V><L><T><A><A><G><N><S><C><R><V><D><V><F><T><N><L><G><Y><R><A><F><S><L><S><F>
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.<BOP>
Q86W42
O95006
OR2F2_HUMAN
Olfactory receptor OR7-6
Homo
<M><E><I><D><N><Q><T><W><V><R><E><F><I><L><L><G><L><S><S><D><W><C><T><Q><I><S><L><F><S><L><F><L><V><T><Y><L><M><T><V><L><G><N><C><L><I><V><L><L><I><R><L><D><S><R><L><H><T><P><M><Y><F><F><L><T><N><L><S><L><V><D><V><S><Y><A><T><S><V><V><P><Q><L><L><A><H><F><L><A><E><H><K><A><I><P><F><Q><S><C><A><A><Q><L><F><F><S><L><A><L><G><G><I><E><F><V><L><L><A><V><M><A><Y><D><R><H><V><A><V><S><D><R><L><R><Y><S><A><I><M><H><G><G><L><C><A><R><L><A><I><T><S><W><V><S><G><S><I><N><S><L><V><Q><T><A><I><T><F><Q><L><P><M><C><T><N><K><F><I><D><H><I><S><C><E><L><L><A><V><V><R><L><A><C><V><D><T><S><S><N><E><A><A><I><M><V><S><S><I><V><L><L><M><T><P><F><C><L><V><L><L><S><Y><I><R><I><I><S><T><I><L><K><I><Q><S><R><E><G><R><K><K><A><F><H><T><C><A><S><H><L><T><V><V><A><L><C><Y><G><T><T><I><F><T><Y><I><Q><P><H><S><G><P><S><V><L><Q><E><K><L><I><S><V><F><Y><A><I><V><M><P><L><L><N><P><V><I><Y><S><L><R><N><K><E><V><K><G><A><W><H><K><L><L><E><K><F><S><G><L><T><S><K><L><G><T>
Odorant receptor.<BOP>
O95006
P43351
RAD52_HUMAN
DNA repair protein RAD52 homolog
Homo
<M><S><G><T><E><E><A><I><L><G><G><R><D><S><H><P><A><A><G><G><G><S><V><L><C><F><G><Q><C><Q><Y><T><A><E><E><Y><Q><A><I><Q><K><A><L><R><Q><R><L><G><P><E><Y><I><S><S><R><M><A><G><G><G><Q><K><V><C><Y><I><E><G><H><R><V><I><N><L><A><N><E><M><F><G><Y><N><G><W><A><H><S><I><T><Q><Q><N><V><D><F><V><D><L><N><N><G><K><F><Y><V><G><V><C><A><F><V><R><V><Q><L><K><D><G><S><Y><H><E><D><V><G><Y><G><V><S><E><G><L><K><S><K><A><L><S><L><E><K><A><R><K><E><A><V><T><D><G><L><K><R><A><L><R><S><F><G><N><A><L><G><N><C><I><L><D><K><D><Y><L><R><S><L><N><K><L><P><R><Q><L><P><L><E><V><D><L><T><K><A><K><R><Q><D><L><E><P><S><V><E><E><A><R><Y><N><S><C><R><P><N><M><A><L><G><H><P><Q><L><Q><Q><V><T><S><P><S><R><P><S><H><A><V><I><P><A><D><Q><D><C><S><S><R><S><L><S><S><S><A><V><E><S><E><A><T><H><Q><R><K><L><R><Q><K><Q><L><Q><Q><Q><F><R><E><R><M><E><K><Q><Q><V><R><V><S><T><P><S><A><E><K><S><E><A><A><P><P><A><P><P><V><T><H><S><T><P><V><T><V><S><E><P><L><L><E><K><D><F><L><A><G><V><T><Q><E><L><I><K><T><L><E><D><N><S><E><K><W><A><V><T><P><D><A><G><D><G><V><V><K><P><S><S><R><A><D><P><A><Q><T><S><D><T><L><A><L><N><N><Q><M><V><T><Q><N><R><T><P><H><S><V><C><H><Q><K><P><Q><A><K><S><G><S><W><D><L><Q><T><Y><S><A><D><Q><R><T><T><G><N><W><E><S><H><R><K><S><Q><D><M><K><K><R><K><Y><D><P><S>
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.<BOP>
P43351
Q8IV38
ANKY2_HUMAN
Ankyrin repeat and MYND domain-containing protein 2
Homo
<M><V><H><I><K><K><G><E><L><T><Q><E><E><K><E><L><L><E><V><I><G><K><G><T><V><Q><E><A><G><T><L><L><S><S><K><N><V><R><V><N><C><L><D><E><N><G><M><T><P><L><M><H><A><A><Y><K><G><K><L><D><M><C><K><L><L><L><R><H><G><A><D><V><N><C><H><Q><H><E><H><G><Y><T><A><L><M><F><A><A><L><S><G><N><K><D><I><T><W><V><M><L><E><A><G><A><E><T><D><V><V><N><S><V><G><R><T><A><A><Q><M><A><A><F><V><G><Q><H><D><C><V><T><I><I><N><N><F><F><P><R><E><R><L><D><Y><Y><T><K><P><Q><G><L><D><K><E><P><K><L><P><P><K><L><A><G><P><L><H><K><I><I><T><T><T><N><L><H><P><V><K><I><V><M><L><V><N><E><N><P><L><L><T><E><E><A><A><L><N><K><C><Y><R><V><M><D><L><I><C><E><K><C><M><K><Q><R><D><M><N><E><V><L><A><M><K><M><H><Y><I><S><C><I><F><Q><K><C><I><N><F><L><K><D><G><E><N><K><L><D><T><L><I><K><S><L><L><K><G><R><A><S><D><G><F><P><V><Y><Q><E><K><I><I><R><E><S><I><R><K><F><P><Y><C><E><A><T><L><L><Q><Q><L><V><R><S><I><A><P><V><E><I><G><S><D><P><T><A><F><S><V><L><T><Q><A><I><T><G><Q><V><G><F><V><D><V><E><F><C><T><T><C><G><E><K><G><A><S><K><R><C><S><V><C><K><M><V><I><Y><C><D><Q><T><C><Q><K><T><H><W><F><T><H><K><K><I><C><K><N><L><K><D><I><Y><E><K><Q><Q><L><E><A><A><K><E><K><R><Q><E><E><N><H><G><K><L><D><V><N><S><N><C><V><N><E><E><Q><P><E><A><E><V><G><I><S><Q><K><D><S><N><P><E><D><S><G><E><G><K><K><E><S><L><E><S><E><A><E><L><E><G><L><Q><D><A><P><A><G><P><Q><V><S><E><E>
May be involved in the trafficking of signaling proteins to the cilia.<BOP>
Q8IV38
P0C646
O52Z1_HUMAN
Olfactory receptor 52Z1P
Homo
<M><G><I><P><G><L><E><G><L><H><T><W><I><S><I><P><F><S><F><M><Y><I><V><A><V><A><G><N><I><F><L><I><F><L><I><M><T><E><R><S><L><H><E><P><M><Y><L><F><L><S><M><L><A><S><A><D><F><L><L><A><T><A><A><A><P><K><V><L><A><I><L><W><F><H><S><M><D><I><S><F><G><S><C><V><S><Q><M><F><F><I><H><F><I><F><V><A><E><S><A><I><L><L><A><M><A><F><D><R><Y><V><A><I><C><Y><P><L><R><Y><T><I><L><T><S><S><A><V><R><K><I><G><I><A><A><V><V><R><S><F><F><I><C><C><P><F><I><F><L><V><Y><R><L><T><Y><C><G><R><N><I><I><P><H><S><Y><C><E><H><I><A><R><L><A><C><G><N><I><N><V><N><I><I><Y><G><L><T><V><A><L><L><S><T><G><L><D><I><V><L><I><I><I><S><Y><T><M><I><L><H><S><V><F><Q><I><S><S><W><A><A><R><F><K><A><L><S><T><C><G><S><H><I><C><V><I><F><M><F><Y><T><P><A><F><F><S><F><L><A><H><R><F><G><G><K><T><I><P><H><H><I><H><I><L><V><G><S><L><Y><V><L><V><P><P><M><L><N><P><I><I><Y><G><V><K><T><K><Q><I><K><D><R><V><I><L><L><F><S><P><I><S><V><C><C>
Odorant receptor.<BOP>
P0C646
Q86T03
PP4P1_HUMAN
Transmembrane protein 55B
Homo
<M><A><A><D><G><E><R><S><P><L><L><S><E><P><I><D><G><G><A><G><G><N><G><L><V><G><P><G><G><S><G><A><G><P><G><G><G><L><T><P><S><A><P><P><Y><G><A><A><F><P><P><F><P><E><G><H><P><A><V><L><P><G><E><D><P><P><P><Y><S><P><L><T><S><P><D><S><G><S><A><P><M><I><T><C><R><V><C><Q><S><L><I><N><V><E><G><K><M><H><Q><H><V><V><K><C><G><V><C><N><E><A><T><P><I><K><N><A><P><P><G><K><K><Y><V><R><C><P><C><N><C><L><L><I><C><K><V><T><S><Q><R><I><A><C><P><R><P><Y><C><K><R><I><I><N><L><G><P><V><H><P><G><P><L><S><P><E><P><Q><P><M><G><V><R><V><I><C><G><H><C><K><N><T><F><L><W><T><E><F><T><D><R><T><L><A><R><C><P><H><C><R><K><V><S><S><I><G><R><R><Y><P><R><K><R><C><I><C><C><F><L><L><G><L><L><L><A><V><T><A><T><G><L><A><F><G><T><W><K><H><A><R><R><Y><G><G><I><Y><A><A><W><A><F><V><I><L><L><A><V><L><C><L><G><R><A><L><Y><W><A><C><M><K><V><S><H><P><V><Q><N><F><S>
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) . Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate . Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules . Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 . May play a role in the regulation of cellular cholesterol metabolism .<BOP>
Q86T03
Q8N4B4
FBX39_HUMAN
F-box only protein 39
Homo
<M><D><E><E><S><E><L><I><Q><P><Q><D><Q><S><C><W><A><F><L><P><D><L><C><L><C><R><V><F><W><W><L><G><D><R><D><R><S><R><A><A><L><V><C><R><K><W><N><Q><M><M><Y><S><A><E><L><W><R><Y><R><T><I><T><F><S><G><R><P><S><R><V><H><A><S><E><V><E><S><A><V><W><Y><V><K><K><F><G><R><Y><L><E><H><L><E><V><K><F><M><N><P><Y><N><A><V><L><T><K><K><F><Q><V><T><M><R><G><L><L><S><C><L><S><K><S><N><N><R><L><K><S><L><S><I><Q><Y><L><E><L><D><R><L><V><W><R><N><S><I><R><S><S><F><I><S><S><L><S><F><F><L><K><K><M><G><K><R><L><D><Y><L><N><L><K><G><A><R><L><T><V><E><Q><G><C><Q><I><L><D><S><L><S><Y><M><R><N><E><N><V><I><S><E><L><N><I><E><D><Y><F><S><H><H><L><A><V><Y><N><S><P><Q><F><K><K><T><M><S><T><F><H><N><L><V><S><L><N><L><N><Y><N><C><I><S><D><E><L><L><E><N><L><C><E><N><A><S><T><L><R><T><I><N><I><K><C><H><V><H><D><P><H><G><Q><V><I><W><G><M><S><W><A><K><L><A><R><Q><A><T><N><L><K><V><N><F><F><F><E><R><I><M><K><Y><E><R><L><A><R><I><L><L><Q><E><I><P><I><R><S><I><S><L><R><S><C><Y><F><S><D><P><D><C><S><M><R><P><T><L><I><D><L><L><P><T><F><R><H><T><L><Q><K><L><T><C><E><F><N><N><N><H><E><S><L><D><E><E><L><H><L><L><I><I><S><C><R><K><L><F><Y><F><K><I><W><A><F><L><D><V><S><F><V><E><R><I><L><K><S><Q><K><E><R><Q><C><A><L><R><V><F><K><A><R><I><Y><T><N><R><Y><E><T><N><E><E><D><K><T><L><Q><E><I><Y><R><K><Y><R><K><L><I><E><S><E><L><S><Y><F><V><I><V><Y><S><V><M>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
Q8N4B4
Q9Y5X4
NR2E3_HUMAN
Retina-specific nuclear receptor
Homo
<M><E><T><R><P><T><A><L><M><S><S><T><V><A><A><A><A><P><A><A><G><A><A><S><R><K><E><S><P><G><R><W><G><L><G><E><D><P><T><G><V><S><P><S><L><Q><C><R><V><C><G><D><S><S><S><G><K><H><Y><G><I><Y><A><C><N><G><C><S><G><F><F><K><R><S><V><R><R><R><L><I><Y><R><C><Q><V><G><A><G><M><C><P><V><D><K><A><H><R><N><Q><C><Q><A><C><R><L><K><K><C><L><Q><A><G><M><N><Q><D><A><V><Q><N><E><R><Q><P><R><S><T><A><Q><V><H><L><D><S><M><E><S><N><T><E><S><R><P><E><S><L><V><A><P><P><A><P><A><G><R><S><P><R><G><P><T><P><M><S><A><A><R><A><L><G><H><H><F><M><A><S><L><I><T><A><E><T><C><A><K><L><E><P><E><D><A><D><E><N><I><D><V><T><S><N><D><P><E><F><P><S><S><P><Y><S><S><S><S><P><C><G><L><D><S><I><H><E><T><S><A><R><L><L><F><M><A><V><K><W><A><K><N><L><P><V><F><S><S><L><P><F><R><D><Q><V><I><L><L><E><E><A><W><S><E><L><F><L><L><G><A><I><Q><W><S><L><P><L><D><S><C><P><L><L><A><P><P><E><A><S><A><A><G><G><A><Q><G><R><L><T><L><A><S><M><E><T><R><V><L><Q><E><T><I><S><R><F><R><A><L><A><V><D><P><T><E><F><A><C><M><K><A><L><V><L><F><K><P><E><T><R><G><L><K><D><P><E><H><V><E><A><L><Q><D><Q><S><Q><V><M><L><S><Q><H><S><K><A><H><H><P><S><Q><P><V><R><F><G><K><L><L><L><L><L><P><S><L><R><F><I><T><A><E><R><I><E><L><L><F><F><R><K><T><I><G><N><T><P><M><E><K><L><L><C><D><M><F><K><N>
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.<BOP>
Q9Y5X4
P63120
VPK19_HUMAN
Proteinase
Homo
<W><A><S><Q><V><S><E><N><R><P><V><C><K><A><I><I><Q><G><K><Q><F><E><G><L><V><D><T><G><A><D><V><S><I><I><A><L><N><Q><W><P><K><N><W><P><K><Q><K><A><V><T><G><L><V><G><I><G><T><A><S><E><V><Y><Q><S><T><E><I><L><H><C><L><G><P><D><N><Q><E><S><T><V><Q><P><M><I><T><S><I><P><L><N><L><W><G><R><D><L><L><Q><Q><W><G><A><E><I><T><M><P><A><P><L><Y><S><P><T><S><Q><K><I><M><T><K><M><G><Y><I><L><G><K><G><L><G><K><N><E><D><G><I><K><I><P><V><E><A><K><I><N><Q><K><R><E><G><I><G><Y><P><F>
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.<BOP>
P63120
Q8NGN8
OR4A4_HUMAN
Olfactory receptor OR11-107
Homo
<M><E><P><R><K><N><V><T><D><F><V><L><L><G><F><T><Q><N><P><K><E><Q><K><V><L><F><V><M><F><L><L><F><Y><I><L><T><M><V><G><N><L><L><I><V><V><T><V><T><V><S><E><T><L><G><S><P><M><S><F><F><L><A><G><L><T><F><I><D><I><I><Y><S><S><S><I><S><P><R><L><I><S><D><L><F><F><G><N><N><S><I><S><F><Q><S><F><M><A><Q><L><F><I><E><H><L><F><G><G><S><E><V><F><L><L><L><V><M><A><Y><D><R><Y><V><A><I><C><K><P><L><H><Y><L><V><I><M><R><Q><W><V><C><V><L><L><L><V><V><S><W><V><G><G><F><L><Q><S><V><F><Q><L><S><I><I><Y><G><L><P><F><C><G><P><N><V><I><D><H><F><F><C><D><M><Y><P><L><L><K><L><A><C><T><D><T><H><V><I><G><L><L><V><V><A><N><G><G><L><S><C><T><I><A><F><L><L><L><L><I><S><Y><G><V><I><L><H><S><L><K><K><L><S><Q><K><G><R><Q><K><A><H><S><T><C><S><S><H><I><T><V><V><V><F><F><F><V><P><C><I><F><M><C><A><R><P><A><R><T><F><S><I><D><K><S><V><S><V><F><Y><T><V><I><T><P><M><L><N><P><L><I><Y><T><L><R><N><S><E><M><T><S><A><M><K><K><L>
Odorant receptor.<BOP>
Q8NGN8
Q8N511
TM199_HUMAN
Transmembrane protein 199
Homo
<M><A><S><S><L><L><A><G><E><R><L><V><R><A><L><G><P><G><G><E><L><E><P><E><R><L><P><R><K><L><R><A><E><L><E><A><A><L><G><K><K><H><K><G><G><D><S><S><S><G><P><Q><R><L><V><S><F><R><L><I><R><D><L><H><Q><H><L><R><E><R><D><S><K><L><Y><L><H><E><L><L><E><G><S><E><I><Y><L><P><E><V><V><K><P><P><R><N><P><E><L><V><A><R><L><E><K><I><K><I><Q><L><A><N><E><E><Y><K><R><I><T><R><N><V><T><C><Q><D><T><R><H><G><G><T><L><S><D><L><G><K><Q><V><R><S><L><K><A><L><V><I><T><I><F><N><F><I><V><T><V><V><A><A><F><V><C><T><Y><L><G><S><Q><Y><I><F><T><E><M><A><S><R><V><L><A><A><L><I><V><A><S><V><V><G><L><A><E><L><Y><V><M><V><R><A><M><E><G><E><L><G><E><L>
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation . May be involved in Golgi homeostasis .<BOP>
Q8N511
Q8N3R3
TCAIM_HUMAN
Tolerance associated gene-1 protein
Homo
<M><F><C><H><L><R><P><M><R><R><L><C><L><E><K><I><F><P><H><W><F><P><F><S><R><A><L><S><G><A><E><A><V><N><A><L><R><P><F><Y><F><A><V><H><P><D><F><F><G><Q><H><P><V><E><R><E><I><N><E><N><S><L><K><R><L><S><V><Y><L><E><N><L><Q><K><P><G><F><K><S><L><K><P><T><Q><L><T><F><Y><V><R><E><T><D><Q><S><S><S><D><G><Q><E><P><F><S><T><S><G><F><R><A><V><K><F><T><L><H><T><R><D><L><L><S><T><V><L><Y><I><L><N><S><C><S><L><S><V><E><H><I><Q><S><L><N><T><N><M><H><T><Q><P><L><K><E><A><K><R><M><P><D><R><P><I><K><W><D><K><S><Y><Y><S><F><T><G><F><K><D><P><D><E><D><L><E><Q><V><S><R><V><E><T><T><L><T><S><W><L><D><N><N><G><K><S><A><V><K><K><L><K><N><S><L><P><L><R><K><E><L><D><R><L><K><D><E><L><S><H><Q><L><Q><L><S><D><I><R><W><Q><R><S><W><G><I><A><H><R><C><S><Q><L><H><S><L><S><R><L><A><Q><Q><N><L><E><T><L><K><K><A><K><G><C><T><I><I><F><T><D><R><S><G><M><S><A><V><G><H><V><M><L><G><T><M><D><V><H><H><H><W><T><K><L><F><E><R><L><P><S><Y><F><D><L><Q><R><R><L><M><I><L><E><D><Q><I><S><Y><L><L><G><G><I><Q><V><V><Y><I><E><E><L><Q><P><V><L><T><L><E><E><Y><Y><S><L><L><D><V><F><Y><N><R><L><L><K><S><R><I><L><F><H><P><R><S><L><R><G><L><Q><M><I><L><N><S><D><R><Y><A><P><S><L><H><E><L><G><H><F><N><I><P><T><L><C><D><P><A><N><L><Q><W><F><I><L><T><K><A><Q><Q><A><R><E><N><M><K><R><K><E><E><L><K><V><I><E><N><E><L><I><Q><A><S><T><K><K><F><S><L><E><K><L><Y><K><E><P><S><I><S><S><I><Q><M><V><D><C><C><K><R><L><L><E><Q><S><L><P><Y><L><H><G><M><H><L><C><I><S><H><F><Y><S><V><M><Q><D><G><D><L><C><I><P><W><N><W><K><N><G><E><A><I><K>
May regulate T-cell apoptosis.<BOP>
Q8N3R3
Q9BRR3
PGAP4_HUMAN
Transmembrane protein 246
Homo
<M><S><T><S><T><S><P><A><A><M><L><L><R><R><L><R><R><L><S><W><G><S><T><A><V><Q><L><F><I><L><T><V><V><T><F><G><L><L><A><P><L><A><C><H><R><L><L><H><S><Y><F><Y><L><R><H><W><H><L><N><Q><M><S><Q><E><F><L><Q><Q><S><L><K><E><G><E><A><A><L><H><Y><F><E><E><L><P><S><A><N><G><S><V><P><I><V><W><Q><A><T><P><R><P><W><L><V><I><T><I><I><T><V><D><R><Q><P><G><F><H><Y><V><L><Q><V><V><S><Q><F><H><R><L><L><Q><Q><C><G><P><Q><C><E><G><H><Q><L><F><L><C><N><V><E><R><S><V><S><H><F><D><A><K><L><L><S><K><Y><V><P><V><A><N><R><Y><E><G><T><E><D><D><Y><G><D><D><P><S><T><N><S><F><E><K><E><K><Q><D><Y><V><Y><C><L><E><S><S><L><Q><T><Y><N><P><D><Y><V><L><M><V><E><D><D><A><V><P><E><E><Q><I><F><P><V><L><E><H><L><L><R><A><R><F><S><E><P><H><L><R><D><A><L><Y><L><K><L><Y><H><P><E><R><L><Q><H><Y><I><N><P><E><P><M><R><I><L><E><W><V><G><V><G><M><L><L><G><P><L><L><T><W><I><Y><M><R><F><A><S><R><P><G><F><S><W><P><V><M><L><F><F><S><L><Y><S><M><G><L><V><E><L><V><G><R><H><Y><F><L><E><L><R><R><L><S><P><S><L><Y><S><V><V><P><A><S><Q><C><C><T><P><A><M><L><F><P><A><P><A><A><R><R><T><L><T><Y><L><S><Q><V><Y><C><H><K><G><F><G><K><D><M><A><L><Y><S><L><L><R><A><K><G><E><R><A><Y><V><V><E><P><N><L><V><K><H><I><G><L><F><S><S><L><R><Y><N><F><H><P><S><L><L>
Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins . Required for the initial step of GPI-GalNAc biosynthesis, transfers GalNAc to GPI in the Golgi after fatty acid remodeling by PGAP2 .<BOP>
Q9BRR3
Q9UBC9
SPRR3_HUMAN
Esophagin
Homo
<M><S><S><Y><Q><Q><K><Q><T><F><T><P><P><P><Q><L><Q><Q><Q><Q><V><K><Q><P><S><Q><P><P><P><Q><E><I><F><V><P><T><T><K><E><P><C><H><S><K><V><P><Q><P><G><N><T><K><I><P><E><P><G><C><T><K><V><P><E><P><G><C><T><K><V><P><E><P><G><C><T><K><V><P><E><P><G><C><T><K><V><P><E><P><G><C><T><K><V><P><E><P><G><C><T><K><V><P><E><P><G><Y><T><K><V><P><E><P><G><S><I><K><V><P><D><Q><G><F><I><K><F><P><E><P><G><A><I><K><V><P><E><Q><G><Y><T><K><V><P><V><P><G><Y><T><K><L><P><E><P><C><P><S><T><V><T><P><G><P><A><Q><Q><K><T><K><Q><K>
Cross-linked envelope protein of keratinocytes.<BOP>
Q9UBC9
P43007
SATT_HUMAN
Solute carrier family 1 member 4
Homo
<M><E><K><S><N><E><T><N><G><Y><L><D><S><A><Q><A><G><P><A><A><G><P><G><A><P><G><T><A><A><G><R><A><R><R><C><A><G><F><L><R><R><Q><A><L><V><L><L><T><V><S><G><V><L><A><G><A><G><L><G><A><A><L><R><G><L><S><L><S><R><T><Q><V><T><Y><L><A><F><P><G><E><M><L><L><R><M><L><R><M><I><I><L><P><L><V><V><C><S><L><V><S><G><A><A><S><L><D><A><S><C><L><G><R><L><G><G><I><A><V><A><Y><F><G><L><T><T><L><S><A><S><A><L><A><V><A><L><A><F><I><I><K><P><G><S><G><A><Q><T><L><Q><S><S><D><L><G><L><E><D><S><G><P><P><P><V><P><K><E><T><V><D><S><F><L><D><L><A><R><N><L><F><P><S><N><L><V><V><A><A><F><R><T><Y><A><T><D><Y><K><V><V><T><Q><N><S><S><S><G><N><V><T><H><E><K><I><P><I><G><T><E><I><E><G><M><N><I><L><G><L><V><L><F><A><L><V><L><G><V><A><L><K><K><L><G><S><E><G><E><D><L><I><R><F><F><N><S><L><N><E><A><T><M><V><L><V><S><W><I><M><W><Y><V><P><V><G><I><M><F><L><V><G><S><K><I><V><E><M><K><D><I><I><V><L><V><T><S><L><G><K><Y><I><F><A><S><I><L><G><H><V><I><H><G><G><I><V><L><P><L><I><Y><F><V><F><T><R><K><N><P><F><R><F><L><L><G><L><L><A><P><F><A><T><A><F><A><T><C><S><S><S><A><T><L><P><S><M><M><K><C><I><E><E><N><N><G><V><D><K><R><I><S><R><F><I><L><P><I><G><A><T><V><N><M><D><G><A><A><I><F><Q><C><V><A><A><V><F><I><A><Q><L><N><N><V><E><L><N><A><G><Q><I><F><T><I><L><V><T><A><T><A><S><S><V><G><A><A><G><V><P><A><G><G><V><L><T><I><A><I><I><L><E><A><I><G><L><P><T><H><D><L><P><L><I><L><A><V><D><W><I><V><D><R><T><T><T><V><V><N><V><E><G><D><A><L><G><A><G><I><L><H><H><L><N><Q><K><A><T><K><K><G><E><Q><E><L><A><E><V><K><V><E><A><I><P><N><C><K><S><E><E><E><T><S><P><L><V><T><H><Q><N><P><A><G><P><V><A><S><A><P><E><L><E><S><K><E><S><V><L>
Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine.<BOP>
P43007
Q14627
I13R2_HUMAN
Interleukin-13-binding protein
Homo
<M><A><F><V><C><L><A><I><G><C><L><Y><T><F><L><I><S><T><T><F><G><C><T><S><S><S><D><T><E><I><K><V><N><P><P><Q><D><F><E><I><V><D><P><G><Y><L><G><Y><L><Y><L><Q><W><Q><P><P><L><S><L><D><H><F><K><E><C><T><V><E><Y><E><L><K><Y><R><N><I><G><S><E><T><W><K><T><I><I><T><K><N><L><H><Y><K><D><G><F><D><L><N><K><G><I><E><A><K><I><H><T><L><L><P><W><Q><C><T><N><G><S><E><V><Q><S><S><W><A><E><T><T><Y><W><I><S><P><Q><G><I><P><E><T><K><V><Q><D><M><D><C><V><Y><Y><N><W><Q><Y><L><L><C><S><W><K><P><G><I><G><V><L><L><D><T><N><Y><N><L><F><Y><W><Y><E><G><L><D><H><A><L><Q><C><V><D><Y><I><K><A><D><G><Q><N><I><G><C><R><F><P><Y><L><E><A><S><D><Y><K><D><F><Y><I><C><V><N><G><S><S><E><N><K><P><I><R><S><S><Y><F><T><F><Q><L><Q><N><I><V><K><P><L><P><P><V><Y><L><T><F><T><R><E><S><S><C><E><I><K><L><K><W><S><I><P><L><G><P><I><P><A><R><C><F><D><Y><E><I><E><I><R><E><D><D><T><T><L><V><T><A><T><V><E><N><E><T><Y><T><L><K><T><T><N><E><T><R><Q><L><C><F><V><V><R><S><K><V><N><I><Y><C><S><D><D><G><I><W><S><E><W><S><D><K><Q><C><W><E><G><E><D><L><S><K><K><T><L><L><R><F><W><L><P><F><G><F><I><L><I><L><V><I><F><V><T><G><L><L><L><R><K><P><N><T><Y><P><K><M><I><P><E><F><F><C><D><T>
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<BOP>
Q14627
P02753
RET4_HUMAN
Plasma retinol-binding protein(1-176)
Homo
<M><K><W><V><W><A><L><L><L><L><A><A><L><G><S><G><R><A><E><R><D><C><R><V><S><S><F><R><V><K><E><N><F><D><K><A><R><F><S><G><T><W><Y><A><M><A><K><K><D><P><E><G><L><F><L><Q><D><N><I><V><A><E><F><S><V><D><E><T><G><Q><M><S><A><T><A><K><G><R><V><R><L><L><N><N><W><D><V><C><A><D><M><V><G><T><F><T><D><T><E><D><P><A><K><F><K><M><K><Y><W><G><V><A><S><F><L><Q><K><G><N><D><D><H><W><I><V><D><T><D><Y><D><T><Y><A><V><Q><Y><S><C><R><L><L><N><L><D><G><T><C><A><D><S><Y><S><F><V><F><S><R><D><P><N><G><L><P><P><E><A><Q><K><I><V><R><Q><R><Q><E><E><L><C><L><A><R><Q><Y><R><L><I><V><H><N><G><Y><C><D><G><R><S><E><R><N><L><L>
Retinol-binding protein that mediates retinol transport in blood plasma . Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane .<BOP>
P02753
P58294
PROK1_HUMAN
Mambakine
Homo
<M><R><G><A><T><R><V><S><I><M><L><L><L><V><T><V><S><D><C><A><V><I><T><G><A><C><E><R><D><V><Q><C><G><A><G><T><C><C><A><I><S><L><W><L><R><G><L><R><M><C><T><P><L><G><R><E><G><E><E><C><H><P><G><S><H><K><V><P><F><F><R><K><R><K><H><H><T><C><P><C><L><P><N><L><L><C><S><R><F><P><D><G><R><Y><R><C><S><M><D><L><K><N><I><N><F>
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.<BOP>
P58294
P62945
RL41_HUMAN
Large ribosomal subunit protein eL41
Homo
<M><R><A><K><W><R><K><K><R><M><R><R><L><K><R><K><R><R><K><M><R><Q><R><S><K>
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.<BOP>
P62945
O95460
MATN4_HUMAN
Matrilin-4
Homo
<M><R><G><L><L><C><W><P><V><L><L><L><L><L><Q><P><W><E><T><Q><L><Q><L><T><G><P><R><C><H><T><G><P><L><D><L><V><F><V><I><D><S><S><R><S><V><R><P><F><E><F><E><T><M><R><Q><F><L><M><G><L><L><R><G><L><N><V><G><P><N><A><T><R><V><G><V><I><Q><Y><S><S><Q><V><Q><S><V><F><P><L><R><A><F><S><R><R><E><D><M><E><R><A><I><R><D><L><V><P><L><A><Q><G><T><M><T><G><L><A><I><Q><Y><A><M><N><V><A><F><S><V><A><E><G><A><R><P><P><E><E><R><V><P><R><V><A><V><I><V><T><D><G><R><P><Q><D><R><V><A><E><V><A><A><Q><A><R><A><R><G><I><E><I><Y><A><V><G><V><Q><R><A><D><V><G><S><L><R><A><M><A><S><P><P><L><D><E><H><V><F><L><V><E><S><F><D><L><I><Q><E><F><G><L><Q><F><Q><S><R><L><C><G><K><D><Q><C><A><E><G><G><H><G><C><Q><H><Q><C><V><N><A><W><A><M><F><H><C><T><C><N><P><G><Y><K><L><A><A><D><N><K><S><C><L><A><I><D><L><C><A><E><G><T><H><G><C><E><H><H><C><V><N><S><P><G><S><Y><F><C><H><C><Q><V><G><F><V><L><Q><Q><D><Q><R><S><C><R><A><I><D><Y><C><S><F><G><N><H><S><C><Q><H><E><C><V><S><T><P><G><G><P><R><C><H><C><R><E><G><H><D><L><Q><P><D><G><R><S><C><Q><V><R><D><L><C><N><G><V><D><H><G><C><E><F><Q><C><V><S><E><G><L><S><Y><R><C><L><C><P><E><G><R><Q><L><Q><A><D><G><K><S><C><N><R><C><R><E><G><H><V><D><L><V><L><L><V><D><G><S><K><S><V><R><P><Q><N><F><E><L><V><K><R><F><V><N><Q><I><V><D><F><L><D><V><S><P><E><G><T><R><V><G><L><V><Q><F><S><S><R><V><R><T><E><F><P><L><G><R><Y><G><T><A><A><E><V><K><Q><A><V><L><A><V><E><Y><M><E><R><G><T><M><T><G><L><A><L><R><H><M><V><E><H><S><F><S><E><A><Q><G><A><R><P><R><A><L><N><V><P><R><V><G><L><V><F><T><D><G><R><S><Q><D><D><I><S><V><W><A><A><R><A><K><E><E><G><I><V><M><Y><A><V><G><V><G><K><A><V><E><A><E><L><R><E><I><A><S><E><P><A><E><L><H><V><S><Y><A><P><D><F><G><T><M><T><H><L><L><E><N><L><R><G><S><I><C><P><E><E><G><I><S><A><G><T><E><L><R><S><P><C><E><C><E><S><L><V><E><F><Q><G><R><T><L><G><A><L><E><S><L><T><L><N><L><A><Q><L><T><A><R><L><E><D><L><E><N><Q><L><A><N><Q><K>
Major component of the extracellular matrix of cartilage.<BOP>
O95460
Q9Y5N6
ORC6_HUMAN
Origin recognition complex subunit 6
Homo
<M><G><S><E><L><I><G><R><L><A><P><R><L><G><L><A><E><P><D><M><L><R><K><A><E><E><Y><L><R><L><S><R><V><K><C><V><G><L><S><A><R><T><T><E><T><S><S><A><V><M><C><L><D><L><A><A><S><W><M><K><C><P><L><D><R><A><Y><L><I><K><L><S><G><L><N><K><E><T><Y><Q><S><C><L><K><S><F><E><C><L><L><G><L><N><S><N><I><G><I><R><D><L><A><V><Q><F><S><C><I><E><A><V><N><M><A><S><K><I><L><K><S><Y><E><S><S><L><P><Q><T><Q><Q><V><D><L><D><L><S><R><P><L><F><T><S><A><A><L><L><S><A><C><K><I><L><K><L><K><V><D><K><N><K><M><V><A><T><S><G><V><K><K><A><I><F><D><R><L><C><K><Q><L><E><K><I><G><Q><Q><V><D><R><E><P><G><D><V><A><T><P><P><R><K><R><K><K><I><V><V><E><A><P><A><K><E><M><E><K><V><E><E><M><P><H><K><P><Q><K><D><E><D><L><T><Q><D><Y><E><E><W><K><R><K><I><L><E><N><A><A><S><A><Q><K><A><T><A><E>
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.<BOP>
Q9Y5N6
Q8IWF6
DEN6A_HUMAN
DENN domain-containing protein 6A
Homo
<M><A><L><R><G><P><A><G><L><G><P><G><S><R><R><P><L><D><E><A><V><A><G><A><E><G><R><E><A><P><A><L><V><A><A><G><G><A><P><E><D><D><E><E><D><D><G><R><G><R><G><L><L><R><W><D><S><F><S><A><W><L><H><C><V><C><V><V><G><F><D><L><E><L><G><Q><A><V><E><V><I><Y><P><Q><H><S><K><L><T><D><R><E><K><T><N><I><C><Y><L><S><F><P><D><S><N><S><G><C><L><G><D><T><Q><F><C><F><R><F><R><Q><S><S><G><R><R><V><S><L><H><C><L><L><D><Q><F><D><K><D><L><P><V><Y><L><K><K><D><P><A><Y><F><Y><G><Y><V><Y><F><R><Q><V><R><D><K><T><L><K><R><G><Y><F><Q><K><S><L><V><L><I><S><K><L><P><Y><I><H><F><F><H><T><V><L><K><Q><I><A><P><E><Y><F><E><K><N><E><P><Y><L><E><A><A><C><N><D><V><D><R><W><P><A><P><V><P><G><K><T><L><H><L><P><I><M><G><V><V><M><K><V><R><I><P><T><C><H><D><K><P><G><T><T><Q><I><V><Q><L><T><Q><Q><V><D><T><N><I><S><V><I><L><P><T><V><H><E><V><D><I><F><R><C><F><C><P><V><F><L><H><S><Q><M><L><W><E><L><V><L><L><G><E><P><L><V><V><M><A><P><S><P><S><E><S><S><E><T><V><L><A><L><V><N><C><I><S><P><L><K><Y><F><S><D><F><R><P><Y><F><T><I><H><D><S><E><F><K><E><Y><T><T><R><T><Q><A><P><P><S><V><I><L><G><V><T><N><P><F><F><A><K><T><L><Q><H><W><P><H><I><I><R><I><G><D><L><K><P><T><G><E><I><P><K><Q><V><K><V><K><K><L><K><N><L><K><T><L><D><S><K><P><G><V><Y><T><S><Y><K><P><Y><L><N><R><D><E><E><I><I><K><Q><L><Q><K><G><V><Q><Q><K><R><P><S><E><A><Q><S><V><I><L><R><R><Y><F><L><E><L><T><Q><S><F><I><I><P><L><E><R><Y><V><A><S><L><M><P><L><Q><K><S><I><S><P><W><K><S><P><P><Q><L><R><Q><F><L><P><E><E><F><M><K><T><L><E><K><T><G><P><Q><L><T><S><R><I><K><G><D><W><I><G><L><Y><R><H><F><L><K><S><P><N><F><D><G><W><F><K><T><R><R><K><E><M><T><Q><K><L><E><A><L><H><L><E><A><L><C><E><E><D><L><L><L><W><I><Q><K><H><T><E><V><E><T><V><D><L><V><L><K><L><K><N><K><L><L><Q><A><D><R><E><H><L><P><V><K><P><D><T><M><E><K><L><R><T><H><I><D><A><I><I><L><A><L><P><E><D><L><Q><G><I><L><L><K><T><G><M><T>
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.<BOP>
Q8IWF6
Q96HR8
NAF1_HUMAN
H/ACA ribonucleoprotein complex non-core subunit NAF1
Homo
<M><E><V><V><E><A><A><A><A><Q><L><E><T><L><K><F><N><G><T><D><F><G><V><G><E><G><P><A><A><P><S><P><G><S><A><P><V><P><G><T><Q><P><P><L><Q><S><F><E><G><S><P><D><A><G><Q><T><V><E><V><K><P><A><G><E><Q><P><L><Q><P><V><L><N><A><V><A><A><G><T><P><A><P><Q><P><Q><P><P><A><E><S><P><A><C><G><D><C><V><T><S><P><G><A><A><E><P><A><R><A><P><D><S><L><E><T><S><D><S><D><S><D><S><D><S><E><T><D><S><D><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><C><I><S><L><P><P><V><L><S><D><G><D><D><D><L><Q><I><E><K><E><N><K><N><F><P><L><K><T><K><D><E><L><L><L><N><E><L><P><S><V><E><E><L><T><I><I><L><P><E><D><I><E><L><K><P><L><G><M><V><S><S><I><I><E><Q><L><V><I><I><E><S><M><T><N><L><P><P><V><N><E><E><T><V><I><F><K><S><D><R><Q><A><A><G><K><I><F><E><I><F><G><P><V><A><H><P><F><Y><V><L><R><F><N><S><S><D><H><I><E><S><K><G><I><K><I><K><E><T><M><Y><F><A><P><S><M><K><D><F><T><Q><Y><I><F><T><E><K><L><K><Q><D><K><G><S><D><A><S><W><K><N><D><Q><E><P><P><P><E><A><L><D><F><S><D><D><E><K><E><K><E><A><K><Q><R><K><K><S><Q><I><Q><G><R><K><K><L><K><S><E><F><N><E><P><G><E><D><F><T><E><V><H><Q><N><W><N><A><H><S><S><A><S><E><H><A><K><G><Y><R><N><R><E><F><T><R><G><F><S><R><A><R><Y><P><R><S><C><H><G><R><P><P><P><Q><H><F><Y><N><S><E><H><M><V><S><Q><E><T><S><G><F><P><S><Q><R><Q><N><N><P><I><M><P><Q><Y><P><F><P><L><P><V><F><D><M><H><N><F><P><L><R><P><P><P><P><P><P><P><P><P><V><N><M><G><W><A><T><P><N><M><A><A><H><P><L><L><N><L><P><Y><S><L><P><P><P><P><P><P><P><P><L><P><P><P><P><S><S><G><D><S><N><S><H><F><G><P><Y><Y>
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.<BOP>
Q96HR8
Q9Y6M5
ZNT1_HUMAN
Solute carrier family 30 member 1
Homo
<M><G><C><W><G><R><N><R><G><R><L><L><C><M><L><A><L><T><F><M><F><M><V><L><E><V><V><V><S><R><V><T><S><S><L><A><M><L><S><D><S><F><H><M><L><S><D><V><L><A><L><V><V><A><L><V><A><E><R><F><A><R><R><T><H><A><T><Q><K><N><T><F><G><W><I><R><A><E><V><M><G><A><L><V><N><A><I><F><L><T><G><L><C><F><A><I><L><L><E><A><I><E><R><F><I><E><P><H><E><M><Q><Q><P><L><V><V><L><G><V><G><V><A><G><L><L><V><N><V><L><G><L><C><L><F><H><H><H><S><G><F><S><Q><D><S><G><H><G><H><S><H><G><G><H><G><H><G><H><G><L><P><K><G><P><R><V><K><S><T><R><P><G><S><S><D><I><N><V><A><P><G><E><Q><G><P><D><Q><E><E><T><N><T><L><V><A><N><T><S><N><S><N><G><L><K><L><D><P><A><D><P><E><N><P><R><S><G><D><T><V><E><V><Q><V><N><G><N><L><V><R><E><P><D><H><M><E><L><E><E><D><R><A><G><Q><L><N><M><R><G><V><F><L><H><V><L><G><D><A><L><G><S><V><I><V><V><V><N><A><L><V><F><Y><F><S><W><K><G><C><S><E><G><D><F><C><V><N><P><C><F><P><D><P><C><K><A><F><V><E><I><I><N><S><T><H><A><S><V><Y><E><A><G><P><C><W><V><L><Y><L><D><P><T><L><C><V><V><M><V><C><I><L><L><Y><T><T><Y><P><L><L><K><E><S><A><L><I><L><L><Q><T><V><P><K><Q><I><D><I><R><N><L><I><K><E><L><R><N><V><E><G><V><E><E><V><H><E><L><H><V><W><Q><L><A><G><S><R><I><I><A><T><A><H><I><K><C><E><D><P><T><S><Y><M><E><V><A><K><T><I><K><D><V><F><H><N><H><G><I><H><A><T><T><I><Q><P><E><F><A><S><V><G><S><K><S><S><V><V><P><C><E><L><A><C><R><T><Q><C><A><L><K><Q><C><C><G><T><L><P><Q><A><P><S><G><K><D><A><E><K><T><P><A><V><S><I><S><C><L><E><L><S><N><N><L><E><K><K><P><R><R><T><K><A><E><N><I><P><A><V><V><I><E><I><K><N><M><P><N><K><Q><P><E><S><S><L>
May be involved in zinc transport out of the cell.<BOP>
Q9Y6M5
Q9BWS9
CHID1_HUMAN
Stabilin-1-interacting chitinase-like protein
Homo
<M><R><T><L><F><N><L><L><W><L><A><L><A><C><S><P><V><H><T><T><L><S><K><S><D><A><K><K><A><A><S><K><T><L><L><E><K><S><Q><F><S><D><K><P><V><Q><D><R><G><L><V><V><T><D><L><K><A><E><S><V><V><L><E><H><R><S><Y><C><S><A><K><A><R><D><R><H><F><A><G><D><V><L><G><Y><V><T><P><W><N><S><H><G><Y><D><V><T><K><V><F><G><S><K><F><T><Q><I><S><P><V><W><L><Q><L><K><R><R><G><R><E><M><F><E><V><T><G><L><H><D><V><D><Q><G><W><M><R><A><V><R><K><H><A><K><G><L><H><I><V><P><R><L><L><F><E><D><W><T><Y><D><D><F><R><N><V><L><D><S><E><D><E><I><E><E><L><S><K><T><V><V><Q><V><A><K><N><Q><H><F><D><G><F><V><V><E><V><W><N><Q><L><L><S><Q><K><R><V><G><L><I><H><M><L><T><H><L><A><E><A><L><H><Q><A><R><L><L><A><L><L><V><I><P><P><A><I><T><P><G><T><D><Q><L><G><M><F><T><H><K><E><F><E><Q><L><A><P><V><L><D><G><F><S><L><M><T><Y><D><Y><S><T><A><H><Q><P><G><P><N><A><P><L><S><W><V><R><A><C><V><Q><V><L><D><P><K><S><K><W><R><S><K><I><L><L><G><L><N><F><Y><G><M><D><Y><A><T><S><K><D><A><R><E><P><V><V><G><A><R><Y><I><Q><T><L><K><D><H><R><P><R><M><V><W><D><S><Q><A><S><E><H><F><F><E><Y><K><K><S><R><S><G><R><H><V><V><F><Y><P><T><L><K><S><L><Q><V><R><L><E><L><A><R><E><L><G><V><G><V><S><I><W><E><L><G><Q><G><L><D><Y><F><Y><D><L><L>
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).<BOP>
Q9BWS9
Q04941
PLP2_HUMAN
Intestinal membrane A4 protein
Homo
<M><A><D><S><E><R><L><S><A><P><G><C><W><A><A><C><T><N><F><S><R><T><R><K><G><I><L><L><F><A><E><I><I><L><C><L><V><I><L><I><C><F><S><A><S><T><P><G><Y><S><S><L><S><V><I><E><M><I><L><A><A><I><F><F><V><V><Y><M><C><D><L><H><T><K><I><P><F><I><N><W><P><W><S><D><F><F><R><T><L><I><A><A><I><L><Y><L><I><T><S><I><V><V><L><V><E><R><G><N><H><S><K><I><V><A><G><V><L><G><L><I><A><T><C><L><F><G><Y><D><A><Y><V><T><F><P><V><R><Q><P><R><H><T><A><A><P><T><D><P><A><D><G><P><V>
May play a role in cell differentiation in the intestinal epithelium.<BOP>
Q04941
P51659
DHB4_HUMAN
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
Homo
<M><G><S><P><L><R><F><D><G><R><V><V><L><V><T><G><A><G><A><G><L><G><R><A><Y><A><L><A><F><A><E><R><G><A><L><V><V><V><N><D><L><G><G><D><F><K><G><V><G><K><G><S><L><A><A><D><K><V><V><E><E><I><R><R><R><G><G><K><A><V><A><N><Y><D><S><V><E><E><G><E><K><V><V><K><T><A><L><D><A><F><G><R><I><D><V><V><V><N><N><A><G><I><L><R><D><R><S><F><A><R><I><S><D><E><D><W><D><I><I><H><R><V><H><L><R><G><S><F><Q><V><T><R><A><A><W><E><H><M><K><K><Q><K><Y><G><R><I><I><M><T><S><S><A><S><G><I><Y><G><N><F><G><Q><A><N><Y><S><A><A><K><L><G><L><L><G><L><A><N><S><L><A><I><E><G><R><K><S><N><I><H><C><N><T><I><A><P><N><A><G><S><R><M><T><Q><T><V><M><P><E><D><L><V><E><A><L><K><P><E><Y><V><A><P><L><V><L><W><L><C><H><E><S><C><E><E><N><G><G><L><F><E><V><G><A><G><W><I><G><K><L><R><W><E><R><T><L><G><A><I><V><R><Q><K><N><H><P><M><T><P><E><A><V><K><A><N><W><K><K><I><C><D><F><E><N><A><S><K><P><Q><S><I><Q><E><S><T><G><S><I><I><E><V><L><S><K><I><D><S><E><G><G><V><S><A><N><H><T><S><R><A><T><S><T><A><T><S><G><F><A><G><A><I><G><Q><K><L><P><P><F><S><Y><A><Y><T><E><L><E><A><I><M><Y><A><L><G><V><G><A><S><I><K><D><P><K><D><L><K><F><I><Y><E><G><S><S><D><F><S><C><L><P><T><F><G><V><I><I><G><Q><K><S><M><M><G><G><G><L><A><E><I><P><G><L><S><I><N><F><A><K><V><L><H><G><E><Q><Y><L><E><L><Y><K><P><L><P><R><A><G><K><L><K><C><E><A><V><V><A><D><V><L><D><K><G><S><G><V><V><I><I><M><D><V><Y><S><Y><S><E><K><E><L><I><C><H><N><Q><F><S><L><F><L><V><G><S><G><G><F><G><G><K><R><T><S><D><K><V><K><V><A><V><A><I><P><N><R><P><P><D><A><V><L><T><D><T><T><S><L><N><Q><A><A><L><Y><R><L><S><G><D><W><N><P><L><H><I><D><P><N><F><A><S><L><A><G><F><D><K><P><I><L><H><G><L><C><T><F><G><F><S><A><R><R><V><L><Q><Q><F><A><D><N><D><V><S><R><F><K><A><I><K><A><R><F><A><K><P><V><Y><P><G><Q><T><L><Q><T><E><M><W><K><E><G><N><R><I><H><F><Q><T><K><V><Q><E><T><G><D><I><V><I><S><N><A><Y><V><D><L><A><P><T><S><G><T><S><A><K><T><P><S><E><G><G><K><L><Q><S><T><F><V><F><E><E><I><G><R><R><L><K><D><I><G><P><E><V><V><K><K><V><N><A><V><F><E><W><H><I><T><K><G><G><N><I><G><A><K><W><T><I><D><L><K><S><G><S><G><K><V><Y><Q><G><P><A><K><G><A><A><D><T><T><I><I><L><S><D><E><D><F><M><E><V><V><L><G><K><L><D><P><Q><K><A><F><F><S><G><R><L><K><A><R><G><N><I><M><L><S><Q><K><L><Q><M><I><L><K><D><Y><A><K><L>
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity .<BOP>
P51659
Q8N456
LRC18_HUMAN
Leucine-rich repeat-containing protein 18
Homo
<M><V><K><G><E><K><G><P><K><G><K><K><I><T><L><K><V><A><R><N><C><I><K><I><T><F><D><G><K><K><R><L><D><L><S><K><M><G><I><T><T><F><P><K><C><I><L><R><L><S><D><M><D><E><L><D><L><S><R><N><L><I><R><K><I><P><D><S><I><S><K><F><Q><N><L><R><W><L><D><L><H><S><N><Y><I><D><K><L><P><E><S><I><G><Q><M><T><S><L><L><Y><L><N><V><S><N><N><R><L><T><S><N><G><L><P><V><E><L><K><Q><L><K><N><I><R><A><V><N><L><G><L><N><H><L><D><S><V><P><T><T><L><G><A><L><K><E><L><H><E><V><G><L><H><D><N><L><L><N><N><I><P><V><S><I><S><K><L><P><K><L><K><K><L><N><I><K><R><N><P><F><P><K><P><G><E><S><E><I><F><I><D><S><I><R><R><L><E><N><L><Y><V><V><E><E><K><D><L><C><A><A><C><L><R><K><C><Q><N><A><R><D><N><L><N><R><I><K><N><M><A><T><T><T><P><R><K><T><I><F><P><N><L><I><S><P><N><S><M><A><K><D><S><W><E><D><W><R><I><R><L><T><S><S>
May be involved in the regulation of spermatogenesis and sperm maturation.<BOP>
Q8N456
O15217
GSTA4_HUMAN
Glutathione S-transferase A4-4
Homo
<M><A><A><R><P><K><L><H><Y><P><N><G><R><G><R><M><E><S><V><R><W><V><L><A><A><A><G><V><E><F><D><E><E><F><L><E><T><K><E><Q><L><Y><K><L><Q><D><G><N><H><L><L><F><Q><Q><V><P><M><V><E><I><D><G><M><K><L><V><Q><T><R><S><I><L><H><Y><I><A><D><K><H><N><L><F><G><K><N><L><K><E><R><T><L><I><D><M><Y><V><E><G><T><L><D><L><L><E><L><L><I><M><H><P><F><L><K><P><D><D><Q><Q><K><E><V><V><N><M><A><Q><K><A><I><I><R><Y><F><P><V><F><E><K><I><L><R><G><H><G><Q><S><F><L><V><G><N><Q><L><S><L><A><D><V><I><L><L><Q><T><I><L><A><L><E><E><K><I><P><N><I><L><S><A><F><P><F><L><Q><E><Y><T><V><K><L><S><N><I><P><T><I><K><R><F><L><E><P><G><S><K><K><K><P><P><P><D><E><I><Y><V><R><T><V><Y><N><I><F><R><P>
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).<BOP>
O15217
Q9NW13
RBM28_HUMAN
RNA-binding motif protein 28
Homo
<M><A><G><L><T><L><F><V><G><R><L><P><P><S><A><R><S><E><Q><L><E><E><L><F><S><Q><V><G><P><V><K><Q><C><F><V><V><T><E><K><G><S><K><A><C><R><G><F><G><Y><V><T><F><S><M><L><E><D><V><Q><R><A><L><K><E><I><T><T><F><E><G><C><K><I><N><V><T><V><A><K><K><K><L><R><N><K><T><K><E><K><G><K><N><E><N><S><E><C><P><K><K><E><P><K><A><K><K><A><K><V><A><D><K><K><A><R><L><I><I><R><N><L><S><F><K><C><S><E><D><D><L><K><T><V><F><A><Q><F><G><A><V><L><E><V><N><I><P><R><K><P><D><G><K><M><R><G><F><G><F><V><Q><F><K><N><L><L><E><A><G><K><A><L><K><G><M><N><M><K><E><I><K><G><R><T><V><A><V><D><W><A><V><A><K><D><K><Y><K><D><T><Q><S><V><S><A><I><G><E><E><K><S><H><E><S><K><H><Q><E><S><V><K><K><K><G><R><E><E><E><D><M><E><E><E><E><N><D><D><D><D><D><D><D><D><E><E><D><G><V><F><D><D><E><D><E><E><E><E><N><I><E><S><K><V><T><K><P><V><Q><I><Q><K><R><A><V><K><R><P><A><P><A><K><S><S><D><H><S><E><E><D><S><D><L><E><E><S><D><S><I><D><D><G><E><E><L><A><Q><S><D><T><S><T><E><E><Q><E><D><K><A><V><Q><V><S><N><K><K><K><R><K><L><P><S><D><V><N><E><G><K><T><V><F><I><R><N><L><S><F><D><S><E><E><E><E><L><G><E><L><L><Q><Q><F><G><E><L><K><Y><V><R><I><V><L><H><P><D><T><E><H><S><K><G><C><A><F><A><Q><F><M><T><Q><E><A><A><Q><K><C><L><L><A><A><S><P><E><N><E><A><G><G><L><K><L><D><G><R><Q><L><K><V><D><L><A><V><T><R><D><E><A><A><K><L><Q><T><T><K><V><K><K><P><T><G><T><R><N><L><Y><L><A><R><E><G><L><I><R><A><G><T><K><A><A><E><G><V><S><A><A><D><M><A><K><R><E><R><F><E><L><L><K><H><Q><K><L><K><D><Q><N><I><F><V><S><R><T><R><L><C><L><H><N><L><P><K><A><V><D><D><K><Q><L><R><K><L><L><L><S><A><T><S><G><E><K><G><V><R><I><K><E><C><R><V><M><R><D><L><K><G><V><H><G><N><M><K><G><Q><S><L><G><Y><A><F><A><E><F><Q><E><H><E><H><A><L><K><A><L><R><L><I><N><N><N><P><E><I><F><G><P><L><K><R><P><I><V><E><F><S><L><E><D><R><R><K><L><K><M><K><E><L><R><I><Q><R><S><L><Q><K><M><R><S><K><P><A><T><G><E><P><Q><K><G><Q><P><E><P><A><K><D><Q><Q><Q><K><A><A><Q><H><H><T><E><E><Q><S><K><V><P><P><E><Q><K><R><K><A><G><S><T><S><W><T><G><F><Q><T><K><A><E><V><E><Q><V><E><L><P><D><G><K><K><R><R><K><V><L><A><L><P><S><H><R><G><P><K><I><R><L><R><D><K><G><K><V><K><P><V><H><P><K><K><P><K><P><Q><I><N><Q><W><K><Q><E><K><Q><Q><L><S><S><E><Q><V><S><R><K><K><A><K><G><N><K><T><E><T><R><F><N><Q><L><V><E><Q><Y><K><Q><K><L><L><G><P><S><K><G><A><P><L><A><K><R><S><K><W><F><D><S>
Nucleolar component of the spliceosomal ribonucleoprotein complexes.<BOP>
Q9NW13
Q9ULM6
CNOT6_HUMAN
Cytoplasmic deadenylase
Homo
<M><P><K><E><K><Y><E><P><P><D><P><R><R><M><Y><T><I><M><S><S><E><E><A><A><N><G><K><K><S><H><W><A><E><L><E><I><S><G><K><V><R><S><L><S><A><S><L><W><S><L><T><H><L><T><A><L><H><L><S><D><N><S><L><S><R><I><P><S><D><I><A><K><L><H><N><L><V><Y><L><D><L><S><S><N><K><I><R><S><L><P><A><E><L><G><N><M><V><S><L><R><E><L><H><L><N><N><N><L><L><R><V><L><P><F><E><L><G><K><L><F><Q><L><Q><T><L><G><L><K><G><N><P><L><T><Q><D><I><L><N><L><Y><Q><E><P><D><G><T><R><R><L><L><N><Y><L><L><D><N><L><S><G><T><A><K><R><I><T><T><E><Q><P><P><P><R><S><W><I><M><L><Q><E><P><D><R><T><R><P><T><A><L><F><S><V><M><C><Y><N><V><L><C><D><K><Y><A><T><R><Q><L><Y><G><Y><C><P><S><W><A><L><N><W><D><Y><R><K><K><A><I><I><Q><E><I><L><S><C><N><A><D><I><V><S><L><Q><E><V><E><T><E><Q><Y><Y><S><F><F><L><V><E><L><K><E><R><G><Y><N><G><F><F><S><P><K><S><R><A><R><T><M><S><E><Q><E><R><K><H><V><D><G><C><A><I><F><F><K><T><E><K><F><T><L><V><Q><K><H><T><V><E><F><N><Q><L><A><M><A><N><S><E><G><S><E><A><M><L><N><R><V><M><T><K><D><N><I><G><V><A><V><L><L><E><L><R><K><E><S><I><E><M><P><S><G><K><P><H><L><G><T><E><K><Q><L><I><L><V><A><N><A><H><M><H><W><D><P><E><Y><S><D><V><K><L><V><Q><T><M><M><F><L><S><E><V><K><N><I><I><D><K><A><S><R><N><L><K><S><S><V><L><G><E><F><G><T><I><P><L><V><L><C><A><D><L><N><S><L><P><D><S><G><V><V><E><Y><L><S><T><G><G><V><E><T><N><H><K><D><F><K><E><L><R><Y><N><E><S><L><T><N><F><S><C><H><G><K><N><G><T><T><N><G><R><I><T><H><G><F><K><L><Q><S><A><Y><E><S><G><L><M><P><Y><T><N><Y><T><F><D><F><K><G><I><I><D><Y><I><F><Y><S><K><P><Q><L><N><T><L><G><I><L><G><P><L><D><H><H><W><L><V><E><N><N><I><S><G><C><P><H><P><L><I><P><S><D><H><F><S><L><F><A><Q><L><E><L><L><L><P><F><L><P><Q><V><N><G><I><H><L><P><G><R><R>
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.<BOP>
Q9ULM6
A0A0B4J234
TVA2_HUMAN
T cell receptor alpha variable 2
Homo
<M><A><L><Q><S><T><L><G><A><V><W><L><G><L><L><L><N><S><L><W><K><V><A><E><S><K><D><Q><V><F><Q><P><S><T><V><A><S><S><E><G><A><V><V><E><I><F><C><N><H><S><V><S><N><A><Y><N><F><F><W><Y><L><H><F><P><G><C><A><P><R><L><L><V><K><G><S><K><P><S><Q><Q><G><R><Y><N><M><T><Y><E><R><F><S><S><S><L><L><I><L><Q><V><R><E><A><D><A><A><V><Y><Y><C><A><V><E>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J234
Q9BY77
PDIP3_HUMAN
S6K1 Aly/REF-like target
Homo
<M><A><D><I><S><L><D><E><L><I><R><K><R><G><A><A><A><K><G><R><L><N><A><R><P><G><V><G><G><V><R><S><R><V><G><I><Q><Q><G><L><L><S><Q><S><T><R><T><A><T><F><Q><Q><R><F><D><A><R><Q><K><I><G><L><S><D><A><R><L><K><L><G><V><K><D><A><R><E><K><L><L><Q><K><D><A><R><F><R><I><K><G><K><V><Q><D><A><R><E><M><L><N><S><R><K><Q><Q><T><T><V><P><Q><K><P><R><Q><V><A><D><A><R><E><K><I><S><L><K><R><S><S><P><A><A><F><I><N><P><P><I><G><T><V><T><P><A><L><K><L><T><K><T><I><Q><V><P><Q><Q><K><A><M><A><P><L><H><P><H><P><A><G><M><R><I><N><V><V><N><N><H><Q><A><K><Q><N><L><Y><D><L><D><E><D><D><D><G><I><A><S><V><P><T><K><Q><M><K><F><A><A><S><G><G><F><L><H><H><M><A><G><L><S><S><S><K><L><S><M><S><K><A><L><P><L><T><K><V><V><Q><N><D><A><Y><T><A><P><A><L><P><S><S><I><R><T><K><A><L><T><N><M><S><R><T><L><V><N><K><E><E><P><P><K><E><L><P><A><A><E><P><V><L><S><P><L><E><G><T><K><M><T><V><N><N><L><H><P><R><V><T><E><E><D><I><V><E><L><F><C><V><C><G><A><L><K><R><A><R><L><V><H><P><G><V><A><E><V><V><F><V><K><K><D><D><A><I><T><A><Y><K><K><Y><N><N><R><C><L><D><G><Q><P><M><K><C><N><L><H><M><N><G><N><V><I><T><S><D><Q><P><I><L><L><R><L><S><D><S><P><S><M><K><K><E><S><E><L><P><R><R><V><N><S><A><S><S><S><N><P><P><A><E><V><D><P><D><T><I><L><K><A><L><F><K><S><S><G><A><S><V><T><T><Q><P><T><E><F><K><I><K><L>
Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex.<BOP>
Q9BY77
Q9BRR0
ZKSC3_HUMAN
Zinc finger protein 47 homolog
Homo
<M><A><R><E><L><S><E><S><T><A><L><D><A><Q><S><T><E><D><Q><M><E><L><L><V><I><K><V><E><E><E><E><A><G><F><P><S><S><P><D><L><G><S><E><G><S><R><E><R><F><R><G><F><R><Y><P><E><A><A><G><P><R><E><A><L><S><R><L><R><E><L><C><R><Q><W><L><Q><P><E><M><H><S><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><G><N><L><Q><S><W><V><R><E><Q><H><P><E><S><G><E><E><V><V><V><L><L><E><Y><L><E><R><Q><L><D><E><P><A><P><Q><V><S><G><V><D><Q><G><Q><E><L><L><C><C><K><M><A><L><L><T><P><A><P><G><S><Q><S><S><Q><F><Q><L><M><K><A><L><L><K><H><E><S><V><G><S><Q><P><L><Q><D><R><V><L><Q><V><P><V><L><A><H><G><G><C><C><R><E><D><K><V><V><A><S><R><L><T><P><E><S><Q><G><L><L><K><V><E><D><V><A><L><T><L><T><P><E><W><T><Q><Q><D><S><S><Q><G><N><L><C><R><D><E><K><Q><E><N><H><G><S><L><V><S><L><G><D><E><K><Q><T><K><S><R><D><L><P><P><A><E><E><L><P><E><K><E><H><G><K><I><S><C><H><L><R><E><D><I><A><Q><I><P><T><C><A><E><A><G><E><Q><E><G><R><L><Q><R><K><Q><K><N><A><T><G><G><R><R><H><I><C><H><E><C><G><K><S><F><A><Q><S><S><G><L><S><K><H><R><R><I><H><T><G><E><K><P><Y><E><C><E><E><C><G><K><A><F><I><G><S><S><A><L><V><I><H><Q><R><V><H><T><G><E><K><P><Y><E><C><E><E><C><G><K><A><F><S><H><S><S><D><L><I><K><H><Q><R><T><H><T><G><E><K><P><Y><E><C><D><D><C><G><K><T><F><S><Q><S><C><S><L><L><E><H><H><R><I><H><T><G><E><K><P><Y><Q><C><S><M><C><G><K><A><F><R><R><S><S><H><L><L><R><H><Q><R><I><H><T><G><D><K><N><V><Q><E><P><E><Q><G><E><A><W><K><S><R><M><E><S><Q><L><E><N><V><E><T><P><M><S><Y><K><C><N><E><C><E><R><S><F><T><Q><N><T><G><L><I><E><H><Q><K><I><H><T><G><E><K><P><Y><Q><C><N><A><C><G><K><G><F><T><R><I><S><Y><L><V><Q><H><Q><R><S><H><V><G><K><N><I><L><S><Q>
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.<BOP>
Q9BRR0
O00623
PEX12_HUMAN
Peroxisome assembly factor 3
Homo
<M><A><E><H><G><A><H><F><T><A><A><S><V><A><D><D><Q><P><S><I><F><E><V><V><A><Q><D><S><L><M><T><A><V><R><P><A><L><Q><H><V><V><K><V><L><A><E><S><N><P><T><H><Y><G><F><L><W><R><W><F><D><E><I><F><T><L><L><D><L><L><L><Q><Q><H><Y><L><S><R><T><S><A><S><F><S><E><N><F><Y><G><L><K><R><I><V><M><G><D><T><H><K><S><Q><R><L><A><S><A><G><L><P><K><Q><Q><L><W><K><S><I><M><F><L><V><L><L><P><Y><L><K><V><K><L><E><K><L><V><S><S><L><R><E><E><D><E><Y><S><I><H><P><P><S><S><R><W><K><R><F><Y><R><A><F><L><A><A><Y><P><F><V><N><M><A><W><E><G><W><F><L><V><Q><Q><L><R><Y><I><L><G><K><A><Q><H><H><S><P><L><L><R><L><A><G><V><Q><L><G><R><L><T><V><Q><D><I><Q><A><L><E><H><K><P><A><K><A><S><M><M><Q><Q><P><A><R><S><V><S><E><K><I><N><S><A><L><K><K><A><V><G><G><V><A><L><S><L><S><T><G><L><S><V><G><V><F><F><L><Q><F><L><D><W><W><Y><S><S><E><N><Q><E><T><I><K><S><L><T><A><L><P><T><P><P><P><P><V><H><L><D><Y><N><S><D><S><P><L><L><P><K><M><K><T><V><C><P><L><C><R><K><T><R><V><N><D><T><V><L><A><T><S><G><Y><V><F><C><Y><R><C><V><F><H><Y><V><R><S><H><Q><A><C><P><I><T><G><Y><P><T><E><V><Q><H><L><I><K><L><Y><S><P><E><N>
Required for protein import into peroxisomes.<BOP>
O00623
D6RGH6
MCIN_HUMAN
Protein Idas
Homo
<M><Q><A><C><G><G><G><A><A><G><R><R><A><F><D><S><I><C><P><N><R><M><L><A><L><P><G><R><A><L><L><C><K><P><G><K><P><E><R><K><F><A><P><P><R><K><F><F><P><G><C><T><G><G><S><P><V><S><V><Y><E><D><P><P><D><A><E><P><T><A><L><P><A><L><T><T><I><D><L><Q><D><L><A><D><C><S><S><L><L><G><S><D><A><P><P><G><G><D><L><A><A><S><Q><N><H><S><H><Q><T><E><A><D><F><N><L><Q><D><F><R><D><T><V><D><D><L><I><S><D><S><S><S><M><M><S><P><T><L><A><S><G><D><F><P><F><S><P><C><D><I><S><P><F><G><P><C><L><S><P><P><L><D><P><R><A><L><Q><S><P><P><L><R><P><P><D><V><P><P><P><E><Q><Y><W><K><E><V><A><D><Q><N><Q><R><A><L><G><D><A><L><V><E><N><N><Q><L><H><V><T><L><T><Q><K><Q><E><E><I><A><S><L><K><E><R><N><V><Q><L><K><E><L><A><S><R><T><R><H><L><A><S><V><L><D><K><L><M><I><T><Q><S><R><D><C><G><A><A><A><E><P><F><L><L><K><A><K><A><K><R><S><L><E><E><L><V><S><A><A><G><Q><D><C><A><E><V><D><A><I><L><R><E><I><S><E><R><C><D><E><A><L><Q><S><R><D><P><K><R><P><R><L><L><P><E><P><A><N><T><D><T><R><P><G><N><L><H><G><A><F><R><G><L><R><T><D><C><S><R><S><A><L><N><L><S><H><S><E><L><E><E><G><G><S><F><S><T><R><I><R><S><H><S><T><I><R><T><L><A><F><P><Q><G><N><A><F><T><I><R><T><A><N><G><G><Y><K><F><R><W><V><P><S>
Transcription regulator specifically required for multiciliate cell differentiation . Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway . Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 .<BOP>
D6RGH6
Q9GZV5
WWTR1_HUMAN
Transcriptional coactivator with PDZ-binding motif
Homo
<M><N><P><A><S><A><P><P><P><L><P><P><P><G><Q><Q><V><I><H><V><T><Q><D><L><D><T><D><L><E><A><L><F><N><S><V><M><N><P><K><P><S><S><W><R><K><K><I><L><P><E><S><F><F><K><E><P><D><S><G><S><H><S><R><Q><S><S><T><D><S><S><G><G><H><P><G><P><R><L><A><G><G><A><Q><H><V><R><S><H><S><S><P><A><S><L><Q><L><G><T><G><A><G><A><A><G><S><P><A><Q><Q><H><A><H><L><R><Q><Q><S><Y><D><V><T><D><E><L><P><L><P><P><G><W><E><M><T><F><T><A><T><G><Q><R><Y><F><L><N><H><I><E><K><I><T><T><W><Q><D><P><R><K><A><M><N><Q><P><L><N><H><M><N><L><H><P><A><V><S><S><T><P><V><P><Q><R><S><M><A><V><S><Q><P><N><L><V><M><N><H><Q><H><Q><Q><Q><M><A><P><S><T><L><S><Q><Q><N><H><P><T><Q><N><P><P><A><G><L><M><S><M><P><N><A><L><T><T><Q><Q><Q><Q><Q><Q><K><L><R><L><Q><R><I><Q><M><E><R><E><R><I><R><M><R><Q><E><E><L><M><R><Q><E><A><A><L><C><R><Q><L><P><M><E><A><E><T><L><A><P><V><Q><A><A><V><N><P><P><T><M><T><P><D><M><R><S><I><T><N><N><S><S><D><P><F><L><N><G><G><P><Y><H><S><R><E><Q><S><T><D><S><G><L><G><L><G><C><Y><S><V><P><T><T><P><E><D><F><L><S><N><V><D><E><M><D><T><G><E><N><A><G><Q><T><P><M><N><I><N><P><Q><Q><T><R><F><P><D><F><L><D><C><L><P><G><T><N><V><D><L><G><T><L><E><S><E><D><L><I><P><L><F><N><D><V><E><S><A><L><N><K><S><E><P><F><L><T><W><L>
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation . In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex . Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition .<BOP>
Q9GZV5
O75845
SC5D_HUMAN
Sterol-C5-desaturase
Homo
<M><D><L><V><L><R><V><A><D><Y><Y><F><F><T><P><Y><V><Y><P><A><T><W><P><E><D><D><I><F><R><Q><A><I><S><L><L><I><V><T><N><V><G><A><Y><I><L><Y><F><F><C><A><T><L><S><Y><Y><F><V><F><D><H><A><L><M><K><H><P><Q><F><L><K><N><Q><V><R><R><E><I><K><F><T><V><Q><A><L><P><W><I><S><I><L><T><V><A><L><F><L><L><E><I><R><G><Y><S><K><L><H><D><D><L><G><E><F><P><Y><G><L><F><E><L><V><V><S><I><I><S><F><L><F><F><T><D><M><F><I><Y><W><I><H><R><G><L><H><H><R><L><V><Y><K><R><L><H><K><P><H><H><I><W><K><I><P><T><P><F><A><S><H><A><F><H><P><I><D><G><F><L><Q><S><L><P><Y><H><I><Y><P><F><I><F><P><L><H><K><V><V><Y><L><S><L><Y><I><L><V><N><I><W><T><I><S><I><H><D><G><D><F><R><V><P><Q><I><L><Q><P><F><I><N><G><S><A><H><H><T><D><H><H><M><F><F><D><Y><N><Y><G><Q><Y><F><T><L><W><D><R><I><G><G><S><F><K><N><P><S><S><F><E><G><K><G><P><L><S><Y><V><K><E><M><T><E><G><K><R><S><S><H><S><G><N><G><C><K><N><E><K><L><F><N><G><E><F><T><K><T><E>
Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol in cholesterol biosynthesis.<BOP>
O75845
Q86U06
RBM23_HUMAN
Splicing factor SF2
Homo
<M><A><S><D><D><F><D><I><V><I><E><A><M><L><E><A><P><Y><K><K><E><E><D><E><Q><Q><R><K><E><V><K><K><D><Y><P><S><N><T><T><S><S><T><S><N><S><G><N><E><T><S><G><S><S><T><I><G><E><T><S><K><K><K><R><S><R><S><H><N><K><S><R><D><R><K><R><S><R><S><R><D><R><D><R><Y><R><R><R><N><S><R><S><R><S><P><G><R><Q><C><R><H><R><S><R><S><W><D><R><R><H><G><S><E><S><R><S><R><D><H><R><R><E><D><R><V><H><Y><R><S><P><P><L><A><T><G><Y><R><Y><G><H><S><K><S><P><H><F><R><E><K><S><P><V><R><E><P><V><D><N><L><S><P><E><E><R><D><A><R><T><V><F><C><M><Q><L><A><A><R><I><R><P><R><D><L><E><D><F><F><S><A><V><G><K><V><R><D><V><R><I><I><S><D><R><N><S><R><R><S><K><G><I><A><Y><V><E><F><C><E><I><Q><S><V><P><L><A><I><G><L><T><G><Q><R><L><L><G><V><P><I><I><V><Q><A><S><Q><A><E><K><N><R><L><A><A><M><A><N><N><L><Q><K><G><N><G><G><P><M><R><L><Y><V><G><S><L><H><F><N><I><T><E><D><M><L><R><G><I><F><E><P><F><G><K><I><D><N><I><V><L><M><K><D><S><D><T><G><R><S><K><G><Y><G><F><I><T><F><S><D><S><E><C><A><R><R><A><L><E><Q><L><N><G><F><E><L><A><G><R><P><M><R><V><G><H><V><T><E><R><L><D><G><G><T><D><I><T><F><P><D><G><D><Q><E><L><D><L><G><S><A><G><G><R><F><Q><L><M><A><K><L><A><E><G><A><G><I><Q><L><P><S><T><A><A><A><A><A><A><A><A><A><Q><A><A><A><L><Q><L><N><G><A><V><P><L><G><A><L><N><P><A><A><L><T><A><L><S><P><A><L><N><L><A><S><Q><C><F><Q><L><S><S><L><F><T><P><Q><T><M>
RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor . Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity .<BOP>
Q86U06
O00241
SIRB1_HUMAN
CD172 antigen-like family member B
Homo
<M><P><V><P><A><S><W><P><H><L><P><S><P><F><L><L><M><T><L><L><L><G><R><L><T><G><V><A><G><E><D><E><L><Q><V><I><Q><P><E><K><S><V><S><V><A><A><G><E><S><A><T><L><R><C><A><M><T><S><L><I><P><V><G><P><I><M><W><F><R><G><A><G><A><G><R><E><L><I><Y><N><Q><K><E><G><H><F><P><R><V><T><T><V><S><E><L><T><K><R><N><N><L><D><F><S><I><S><I><S><N><I><T><P><A><D><A><G><T><Y><Y><C><V><K><F><R><K><G><S><P><D><D><V><E><F><K><S><G><A><G><T><E><L><S><V><R><A><K><P><S><A><P><V><V><S><G><P><A><V><R><A><T><P><E><H><T><V><S><F><T><C><E><S><H><G><F><S><P><R><D><I><T><L><K><W><F><K><N><G><N><E><L><S><D><F><Q><T><N><V><D><P><A><G><D><S><V><S><Y><S><I><H><S><T><A><R><V><V><L><T><R><G><D><V><H><S><Q><V><I><C><E><I><A><H><I><T><L><Q><G><D><P><L><R><G><T><A><N><L><S><E><A><I><R><V><P><P><T><L><E><V><T><Q><Q><P><M><R><A><E><N><Q><A><N><V><T><C><Q><V><S><N><F><Y><P><R><G><L><Q><L><T><W><L><E><N><G><N><V><S><R><T><E><T><A><S><T><L><I><E><N><K><D><G><T><Y><N><W><M><S><W><L><L><V><N><T><C><A><H><R><D><D><V><V><L><T><C><Q><V><E><H><D><G><Q><Q><A><V><S><K><S><Y><A><L><E><I><S><A><H><Q><K><E><H><G><S><D><I><T><H><E><A><A><L><A><P><T><A><P><L><L><V><A><L><L><L><G><P><K><L><L><L><V><V><G><V><S><A><I><Y><I><C><W><K><Q><K><A>
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP .<BOP>
O00241
Q92637
FCGRB_HUMAN
Fc-gamma RIB
Homo
<M><W><F><L><T><T><L><L><L><W><V><P><V><D><G><Q><V><D><T><T><K><A><V><I><T><L><Q><P><P><W><V><S><V><F><Q><E><E><T><V><T><L><H><C><E><V><L><H><L><P><G><S><S><S><T><Q><W><F><L><N><G><T><A><T><Q><T><S><T><P><S><Y><R><I><T><S><A><S><V><N><D><S><G><E><Y><R><C><Q><R><G><L><S><G><R><S><D><P><I><Q><L><E><I><H><R><G><W><L><L><L><Q><V><S><S><R><V><F><M><E><G><E><P><L><A><L><R><C><H><A><W><K><D><K><L><V><Y><N><V><L><Y><Y><R><N><G><K><A><F><K><F><F><H><W><N><S><N><L><T><I><L><K><T><N><I><S><H><N><G><T><Y><H><C><S><G><M><G><K><H><R><Y><T><S><A><G><I><S><Q><Y><T><V><K><G><L><Q><L><P><T><P><V><W><F><H><V><L><F><Y><L><A><V><G><I><M><F><L><V><N><T><V><L><W><V><T><I><R><K><E><L><K><R><K><K><K><W><N><L><E><I><S><L><D><S><G><H><E><K><K><V><I><S><S><L><Q><E><D><R><H><L><E><E><E><L><K><C><Q><E><Q><K><E><E><Q><L><Q><E><G><V><H><R><K><E><P><Q><G><A><T>
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.<BOP>
Q92637
Q8N2I9
STK40_HUMAN
Sugen kinase 495
Homo
<M><K><R><R><A><S><D><R><G><A><G><E><T><S><A><R><A><K><A><L><G><S><G><I><S><G><N><N><A><K><R><A><G><P><F><I><L><G><P><R><L><G><N><S><P><V><P><S><I><V><Q><C><L><A><R><K><D><G><T><D><D><F><Y><Q><L><K><I><L><T><L><E><E><R><G><D><Q><G><I><E><S><Q><E><E><R><Q><G><K><M><L><L><H><T><E><Y><S><L><L><S><L><L><H><T><Q><D><G><V><V><H><H><H><G><L><F><Q><D><R><T><C><E><I><V><E><D><T><E><S><S><R><M><V><K><K><M><K><K><R><I><C><L><V><L><D><C><L><C><A><H><D><F><S><D><K><T><A><D><L><I><N><L><Q><H><Y><V><I><K><E><K><R><L><S><E><R><E><T><V><V><I><F><Y><D><V><V><R><V><V><E><A><L><H><Q><K><N><I><V><H><R><D><L><K><L><G><N><M><V><L><N><K><R><T><H><R><I><T><I><T><N><F><C><L><G><K><H><L><V><S><E><G><D><L><L><K><D><Q><R><G><S><P><A><Y><I><S><P><D><V><L><S><G><R><P><Y><R><G><K><P><S><D><M><W><A><L><G><V><V><L><F><T><M><L><Y><G><Q><F><P><F><Y><D><S><I><P><Q><E><L><F><R><K><I><K><A><A><E><Y><T><I><P><E><D><G><R><V><S><E><N><T><V><C><L><I><R><K><L><L><V><L><D><P><Q><Q><R><L><A><A><A><D><V><L><E><A><L><S><A><I><I><A><S><W><Q><S><L><S><S><L><S><G><P><L><Q><V><V><P><D><I><D><D><Q><M><S><N><A><D><S><S><Q><E><A><K><V><T><E><E><C><S><Q><Y><E><F><E><N><Y><M><R><Q><Q><L><L><L><A><E><E><K><S><S><I><H><D><A><R><S><W><V><P><K><R><Q><F><G><S><A><P><P><V><R><R><L><G><H><D><A><Q><P><M><T><S><L><D><T><A><I><L><A><Q><R><Y><L><R><K>
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.<BOP>
Q8N2I9
Q9NYJ1
COA4_HUMAN
E2-induced gene 2 protein
Homo
<M><S><T><S><V><P><Q><G><H><T><W><T><Q><R><V><K><K><D><D><E><E><E><D><P><L><D><Q><L><I><S><R><S><G><C><A><A><S><H><F><A><V><Q><E><C><M><A><Q><H><Q><D><W><R><Q><C><Q><P><Q><V><Q><A><F><K><D><C><M><S><E><Q><Q><A><R><R><Q><E><E><L><Q><R><R><Q><E><Q><A><G><A><H><H>
Putative COX assembly factor.<BOP>
Q9NYJ1
Q8NGN5
O10G8_HUMAN
Olfactory receptor OR11-282
Homo
<M><S><N><A><S><L><L><T><A><F><I><L><M><G><L><P><H><A><P><A><L><D><A><P><L><F><G><V><F><L><V><V><Y><V><L><T><V><L><G><N><L><L><I><L><L><V><I><R><V><D><S><H><L><H><T><T><M><Y><Y><F><L><T><N><L><S><F><I><D><M><W><F><S><T><V><T><V><P><K><L><L><M><T><L><V><F><P><S><G><R><A><I><S><F><H><S><C><M><A><Q><L><Y><F><F><H><F><L><G><G><T><E><C><F><L><Y><R><V><M><S><C><D><R><Y><L><A><I><S><Y><P><L><R><Y><T><S><M><M><T><G><R><S><C><T><L><L><A><T><S><T><W><L><S><G><S><L><H><S><A><V><Q><A><I><L><T><F><H><L><P><Y><C><G><P><N><W><I><Q><H><Y><L><C><D><A><P><P><I><L><K><L><A><C><A><D><T><S><A><I><E><T><V><I><F><V><T><V><G><I><V><A><S><G><C><F><V><L><I><V><L><S><Y><V><S><I><V><C><S><I><L><R><I><R><T><S><E><G><K><H><R><A><F><Q><T><C><A><S><H><C><I><V><V><L><C><F><F><G><P><G><L><F><I><Y><L><R><P><G><S><R><K><A><V><D><G><V><V><A><V><F><Y><T><V><L><T><P><L><L><N><P><V><V><Y><T><L><R><N><K><E><V><K><K><A><L><L><K><L><K><D><K><V><A><H><S><Q><S><K>
Odorant receptor.<BOP>
Q8NGN5
A8MT65
ZN891_HUMAN
Zinc finger protein 891
Homo
<M><A><V><M><D><L><S><S><P><W><A><L><T><K><Q><D><S><A><C><F><H><L><R><N><A><E><E><E><R><M><I><A><V><F><L><T><T><W><L><Q><E><P><M><T><F><K><D><V><A><V><E><F><T><Q><E><E><W><M><M><L><D><S><A><Q><R><S><L><Y><R><D><V><M><L><E><N><Y><R><N><L><T><S><V><E><Y><Q><L><Y><R><L><T><V><I><S><P><L><D><Q><E><E><I><R><N><M><K><K><R><I><P><Q><A><I><C><P><D><Q><K><I><Q><P><K><T><K><E><S><T><V><Q><K><I><L><W><E><E><P><S><N><A><V><K><M><I><K><L><T><M><H><N><W><S><S><T><L><R><E><D><W><E><C><H><K><I><R><K><Q><H><K><I><P><G><G><H><W><R><Q><M><I><Y><A><P><K><K><T><V><P><Q><E><L><F><R><D><Y><H><E><L><E><E><N><S><K><L><G><S><K><L><I><F><S><Q><S><I><F><T><S><K><H><C><Q><K><C><Y><S><E><I><G><C><L><K><H><N><S><I><I><N><N><Y><V><K><N><S><I><S><E><K><L><Y><E><S><H><E><C><D><T><T><L><W><H><F><Q><R><N><Q><T><V><Q><K><E><Y><T><Y><S><K><H><G><M><H><F><T><H><N><M><F><P><V><P><N><N><L><H><M><A><Q><N><A><C><E><C><N><K><D><E><T><L><C><H><Q><S><S><L><K><K><Q><G><Q><T><H><T><E><K><K><H><E><C><N><Q><C><G><K><A><F><K><R><I><S><N><L><T><L><Y><K><K><S><H><M><G><E><K><Q><Y><E><C><K><E><C><G><K><V><F><N><D><S><S><T><L><R><R><H><V><R><T><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><A><F><S><Q><K><T><S><L><K><A><H><M><R><T><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><S><F><G><T><S><S><Y><L><I><V><H><K><R><I><H><T><G><E><K><L><Y><E><C><S><E><C><G><K><A><F><N><T><S><S><H><L><K><V><H><K><K><I><H><T><G><E><N><V><Y><E><C><S><D><C><G><K><V><F><S><G><V><S><S><L><R><M><H><I><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><R><K><A><F><S><V><S><S><S><L><R><R><H><V><R><I><H><T><G><E><K><P><Y><E><C><I><Q><C><G><K><A><F><S><Q><S><S><S><L><I><I><H><K><R><I><H><T><E><R><E><T><L>
May be involved in transcriptional regulation.<BOP>
A8MT65
Q15916
ZBTB6_HUMAN
Zinc finger protein with interaction domain
Homo
<M><A><A><E><S><D><V><L><H><F><Q><F><E><Q><Q><G><D><V><V><L><Q><K><M><N><L><L><R><Q><Q><N><L><F><C><D><V><S><I><Y><I><N><D><T><E><F><Q><G><H><K><V><I><L><A><A><C><S><T><F><M><R><D><Q><F><L><L><T><Q><S><K><H><V><R><I><T><I><L><Q><S><A><E><V><G><R><K><L><L><L><S><C><Y><T><G><A><L><E><V><K><R><K><E><L><L><K><Y><L><T><A><A><S><Y><L><Q><M><V><H><I><V><E><K><C><T><E><A><L><S><K><Y><L><E><I><D><L><S><M><K><N><N><N><Q><H><T><D><L><C><Q><S><S><D><P><D><V><K><N><E><D><E><N><S><D><K><D><C><E><I><I><E><I><S><E><D><S><P><V><N><I><D><F><H><V><K><E><E><E><S><N><A><L><Q><S><T><V><E><S><L><T><S><E><R><K><E><M><K><S><P><E><L><S><T><V><D><I><G><F><K><D><N><E><I><C><I><L><H><V><E><S><I><S><T><A><G><V><E><N><G><Q><F><S><Q><P><C><T><S><S><K><A><S><M><Y><F><S><E><T><Q><H><S><L><I><N><S><T><V><E><S><R><V><A><E><V><P><G><N><Q><D><Q><G><L><F><C><E><N><T><E><G><S><Y><G><T><V><S><E><I><Q><N><L><E><E><G><Y><S><L><R><H><Q><C><P><R><C><P><R><G><F><L><H><V><E><N><Y><L><R><H><L><K><M><H><K><L><F><L><C><L><Q><C><G><K><T><F><T><Q><K><K><N><L><N><R><H><I><R><G><H><M><G><I><R><P><F><Q><C><T><V><C><L><K><T><F><T><A><K><S><T><L><Q><D><H><L><N><I><H><S><G><D><R><P><Y><K><C><H><C><C><D><M><D><F><K><H><K><S><A><L><K><K><H><L><T><S><V><H><G><R><S><S><G><E><K><L><S><R><P><D><L><K><R><Q><S><L><L>
May be involved in transcriptional regulation.<BOP>
Q15916
O14576
DC1I1_HUMAN
Dynein intermediate chain 1, cytosolic
Homo
<M><S><D><K><S><D><L><K><A><E><L><E><R><K><K><Q><R><L><A><Q><I><R><E><E><K><K><R><K><E><E><E><R><K><K><K><E><A><D><M><Q><Q><K><K><E><P><V><Q><D><D><S><D><L><D><R><K><R><R><E><T><E><A><L><L><Q><S><I><G><I><S><P><E><P><P><L><V><Q><P><L><H><F><L><T><W><D><T><C><Y><F><H><Y><L><V><P><T><P><M><S><P><S><S><K><S><V><S><T><P><S><E><A><G><S><Q><D><S><G><D><L><G><P><L><T><R><T><L><Q><W><D><T><D><P><S><V><L><Q><L><Q><S><D><S><E><L><G><R><R><L><H><K><L><G><V><S><K><V><T><Q><V><D><F><L><P><R><E><V><V><S><Y><S><K><E><T><Q><T><P><L><A><T><H><Q><S><E><E><D><E><E><D><E><E><M><V><E><S><K><V><G><Q><D><S><E><L><E><N><Q><D><K><K><Q><E><V><K><E><A><P><P><R><E><L><T><E><E><E><K><Q><Q><I><L><H><S><E><E><F><L><I><F><F><D><R><T><I><R><V><I><E><R><A><L><A><E><D><S><D><I><F><F><D><Y><S><G><R><E><L><E><E><K><D><G><D><V><Q><A><G><A><N><L><S><F><N><R><Q><F><Y><D><E><H><W><S><K><H><R><V><V><T><C><M><D><W><S><L><Q><Y><P><E><L><M><V><A><S><Y><N><N><N><E><D><A><P><H><E><P><D><G><V><A><L><V><W><N><M><K><F><K><K><T><T><P><E><Y><V><F><H><C><Q><S><S><V><M><S><V><C><F><A><R><F><H><P><N><L><V><V><G><G><T><Y><S><G><Q><I><V><L><W><D><N><R><S><H><R><R><T><P><V><Q><R><T><P><L><S><A><A><A><H><T><H><P><V><Y><C><V><N><V><V><G><T><Q><N><A><H><N><L><I><T><V><S><T><D><G><K><M><C><S><W><S><L><D><M><L><S><T><P><Q><E><S><M><E><L><V><Y><N><K><S><K><P><V><A><V><T><G><M><A><F><P><T><G><D><V><N><N><F><V><V><G><S><E><E><G><T><V><Y><T><A><C><R><H><G><S><K><A><G><I><G><E><V><F><E><G><H><Q><G><P><V><T><G><I><N><C><H><M><A><V><G><P><I><D><F><S><H><L><F><V><T><S><S><F><D><W><T><V><K><L><W><T><T><K><H><N><K><P><L><Y><S><F><E><D><N><A><D><Y><V><Y><D><V><M><W><S><P><V><H><P><A><L><F><A><C><V><D><G><M><G><R><L><D><L><W><N><L><N><N><D><T><E><V><P><T><A><S><V><A><I><E><G><A><S><A><L><N><R><V><R><W><A><Q><A><G><K><E><V><A><V><G><D><S><E><G><R><I><W><V><Y><D><V><G><E><L><A><V><P><H><N><D><E><W><T><R><F><A><R><T><L><V><E><I><R><A><N><R><A><D><S><E><E><E><G><T><V><E><L><S><A>
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.<BOP>
O14576
Q7L9L4
MOB1B_HUMAN
Mps one binder kinase activator-like 1A
Homo
<M><S><F><L><F><G><S><R><S><S><K><T><F><K><P><K><K><N><I><P><E><G><S><H><Q><Y><E><L><L><K><H><A><E><A><T><L><G><S><G><N><L><R><M><A><V><M><L><P><E><G><E><D><L><N><E><W><V><A><V><N><T><V><D><F><F><N><Q><I><N><M><L><Y><G><T><I><T><D><F><C><T><E><E><S><C><P><V><M><S><A><G><P><K><Y><E><Y><H><W><A><D><G><T><N><I><K><K><P><I><K><C><S><A><P><K><Y><I><D><Y><L><M><T><W><V><Q><D><Q><L><D><D><E><T><L><F><P><S><K><I><G><V><P><F><P><K><N><F><M><S><V><A><K><T><I><L><K><R><L><F><R><V><Y><A><H><I><Y><H><Q><H><F><D><P><V><I><Q><L><Q><E><E><A><H><L><N><T><S><F><K><H><F><I><F><F><V><Q><E><F><N><L><I><D><R><R><E><L><A><P><L><Q><E><L><I><E><K><L><T><S><K><D><R>
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.<BOP>
Q7L9L4
P22748
CAH4_HUMAN
Carbonic anhydrase IV
Homo
<M><R><M><L><L><A><L><L><A><L><S><A><A><R><P><S><A><S><A><E><S><H><W><C><Y><E><V><Q><A><E><S><S><N><Y><P><C><L><V><P><V><K><W><G><G><N><C><Q><K><D><R><Q><S><P><I><N><I><V><T><T><K><A><K><V><D><K><K><L><G><R><F><F><F><S><G><Y><D><K><K><Q><T><W><T><V><Q><N><N><G><H><S><V><M><M><L><L><E><N><K><A><S><I><S><G><G><G><L><P><A><P><Y><Q><A><K><Q><L><H><L><H><W><S><D><L><P><Y><K><G><S><E><H><S><L><D><G><E><H><F><A><M><E><M><H><I><V><H><E><K><E><K><G><T><S><R><N><V><K><E><A><Q><D><P><E><D><E><I><A><V><L><A><F><L><V><E><A><G><T><Q><V><N><E><G><F><Q><P><L><V><E><A><L><S><N><I><P><K><P><E><M><S><T><T><M><A><E><S><S><L><L><D><L><L><P><K><E><E><K><L><R><H><Y><F><R><Y><L><G><S><L><T><T><P><T><C><D><E><K><V><V><W><T><V><F><R><E><P><I><Q><L><H><R><E><Q><I><L><A><F><S><Q><K><L><Y><Y><D><K><E><Q><T><V><S><M><K><D><N><V><R><P><L><Q><Q><L><G><Q><R><T><V><I><K><S><G><A><P><G><R><P><L><P><W><A><L><P><A><L><L><G><P><M><L><A><C><L><L><A><G><F><L><R>
Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH . May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis . It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid .<BOP>
P22748
Q9UK32
KS6A6_HUMAN
pp90RSK4
Homo
<M><L><P><F><A><P><Q><D><E><P><W><D><R><E><M><E><V><F><S><G><G><G><A><S><S><G><E><V><N><G><L><K><M><V><D><E><P><M><E><E><G><E><A><D><S><C><H><D><E><G><V><V><K><E><I><P><I><T><H><H><V><K><E><G><Y><E><K><A><D><P><A><Q><F><E><L><L><K><V><L><G><Q><G><S><F><G><K><V><F><L><V><R><K><K><T><G><P><D><A><G><Q><L><Y><A><M><K><V><L><K><K><A><S><L><K><V><R><D><R><V><R><T><K><M><E><R><D><I><L><V><E><V><N><H><P><F><I><V><K><L><H><Y><A><F><Q><T><E><G><K><L><Y><L><I><L><D><F><L><R><G><G><D><V><F><T><R><L><S><K><E><V><L><F><T><E><E><D><V><K><F><Y><L><A><E><L><A><L><A><L><D><H><L><H><Q><L><G><I><V><Y><R><D><L><K><P><E><N><I><L><L><D><E><I><G><H><I><K><L><T><D><F><G><L><S><K><E><S><V><D><Q><E><K><K><A><Y><S><F><C><G><T><V><E><Y><M><A><P><E><V><V><N><R><R><G><H><S><Q><S><A><D><W><W><S><Y><G><V><L><M><F><E><M><L><T><G><T><L><P><F><Q><G><K><D><R><N><E><T><M><N><M><I><L><K><A><K><L><G><M><P><Q><F><L><S><A><E><A><Q><S><L><L><R><M><L><F><K><R><N><P><A><N><R><L><G><S><E><G><V><E><E><I><K><R><H><L><F><F><A><N><I><D><W><D><K><L><Y><K><R><E><V><Q><P><P><F><K><P><A><S><G><K><P><D><D><T><F><C><F><D><P><E><F><T><A><K><T><P><K><D><S><P><G><L><P><A><S><A><N><A><H><Q><L><F><K><G><F><S><F><V><A><T><S><I><A><E><E><Y><K><I><T><P><I><T><S><A><N><V><L><P><I><V><Q><I><N><G><N><A><A><Q><F><G><E><V><Y><E><L><K><E><D><I><G><V><G><S><Y><S><V><C><K><R><C><I><H><A><T><T><N><M><E><F><A><V><K><I><I><D><K><S><K><R><D><P><S><E><E><I><E><I><L><M><R><Y><G><Q><H><P><N><I><I><T><L><K><D><V><F><D><D><G><R><Y><V><Y><L><V><T><D><L><M><K><G><G><E><L><L><D><R><I><L><K><Q><K><C><F><S><E><R><E><A><S><D><I><L><Y><V><I><S><K><T><V><D><Y><L><H><C><Q><G><V><V><H><R><D><L><K><P><S><N><I><L><Y><M><D><E><S><A><S><A><D><S><I><R><I><C><D><F><G><F><A><K><Q><L><R><G><E><N><G><L><L><L><T><P><C><Y><T><A><N><F><V><A><P><E><V><L><M><Q><Q><G><Y><D><A><A><C><D><I><W><S><L><G><V><L><F><Y><T><M><L><A><G><Y><T><P><F><A><N><G><P><N><D><T><P><E><E><I><L><L><R><I><G><N><G><K><F><S><L><S><G><G><N><W><D><N><I><S><D><G><A><K><D><L><L><S><H><M><L><H><M><D><P><H><Q><R><Y><T><A><E><Q><I><L><K><H><S><W><I><T><H><R><D><Q><L><P><N><D><Q><P><K><R><N><D><V><S><H><V><V><K><G><A><M><V><A><T><Y><S><A><L><T><H><K><T><F><Q><P><V><L><E><P><V><A><A><S><S><L><A><Q><R><R><S><M><K><K><R><T><S><T><G><L>
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.<BOP>
Q9UK32
A0A539
TVB42_HUMAN
T cell receptor beta variable 4-2
Homo
<M><G><C><R><L><L><C><C><A><V><L><C><L><L><G><A><V><P><M><E><T><G><V><T><Q><T><P><R><H><L><V><M><G><M><T><N><K><K><S><L><K><C><E><Q><H><L><G><H><N><A><M><Y><W><Y><K><Q><S><A><K><K><P><L><E><L><M><F><V><Y><N><F><K><E><Q><T><E><N><N><S><V><P><S><R><F><S><P><E><C><P><N><S><S><H><L><F><L><H><L><H><T><L><Q><P><E><D><S><A><L><Y><L><C><A><S><S><Q>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A539
Q7L190
DPPA4_HUMAN
Developmental pluripotency-associated protein 4
Homo
<M><L><R><G><S><A><S><S><T><S><M><E><K><A><K><G><K><E><W><T><S><T><E><K><S><R><E><E><D><Q><Q><A><S><N><Q><P><N><S><I><A><L><P><G><T><S><A><K><R><T><K><E><K><M><S><I><K><G><S><K><V><L><C><P><K><K><K><A><E><H><T><D><N><P><R><P><Q><K><K><I><P><I><P><P><L><P><S><K><L><P><P><V><N><L><I><H><R><D><I><L><R><A><W><C><Q><Q><L><K><L><S><S><K><G><Q><K><L><D><A><Y><K><R><L><C><A><F><A><Y><P><N><Q><K><D><F><P><S><T><A><K><E><A><K><I><R><K><S><L><Q><K><K><L><K><V><E><K><G><E><T><S><L><Q><S><S><E><T><H><P><P><E><V><A><L><P><P><V><G><E><P><P><A><L><E><N><S><T><A><L><L><E><G><V><N><T><V><V><V><T><T><S><A><P><E><A><L><L><A><S><W><A><R><I><S><A><R><A><R><T><P><E><A><V><E><S><P><Q><E><A><S><G><V><R><W><C><V><V><H><G><K><S><L><P><A><D><T><D><G><W><V><H><L><Q><F><H><A><G><Q><A><W><V><P><E><K><Q><E><G><R><V><S><A><L><F><L><L><P><A><S><N><F><P><P><P><H><L><E><D><N><M><L><C><P><K><C><V><H><R><N><K><V><L><I><K><S><L><Q><W><E>
May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.<BOP>
Q7L190
Q9UPQ4
TRI35_HUMAN
Hemopoietic lineage switch protein 5
Homo
<M><E><R><S><P><D><V><S><P><G><P><S><R><S><F><K><E><E><L><L><C><A><V><C><Y><D><P><F><R><D><A><V><T><L><R><C><G><H><N><F><C><R><G><C><V><S><R><C><W><E><V><Q><V><S><P><T><C><P><V><C><K><D><R><A><S><P><A><D><L><R><T><N><H><T><L><N><N><L><V><E><K><L><L><R><E><E><A><E><G><A><R><W><T><S><Y><R><F><S><R><V><C><R><L><H><R><G><Q><L><S><L><F><C><L><E><D><K><E><L><L><C><C><S><C><Q><A><D><P><R><H><Q><G><H><R><V><Q><P><V><K><D><T><A><H><D><F><R><A><K><C><R><N><M><E><H><A><L><R><E><K><A><K><A><F><W><A><M><R><R><S><Y><E><A><I><A><K><H><N><Q><V><E><A><A><W><L><E><G><R><I><R><Q><E><F><D><K><L><R><E><F><L><R><V><E><E><Q><A><I><L><D><A><M><A><E><E><T><R><Q><K><Q><L><L><A><D><E><K><M><K><Q><L><T><E><E><T><E><V><L><A><H><E><I><E><R><L><Q><M><E><M><K><E><D><D><V><S><F><L><M><K><H><K><S><R><K><R><R><L><F><C><T><M><E><P><E><P><V><Q><P><G><M><L><I><D><V><C><K><Y><L><G><S><L><Q><Y><R><V><W><K><K><M><L><A><S><V><E><S><V><P><F><S><F><D><P><N><T><A><A><G><W><L><S><V><S><D><D><L><T><S><V><T><N><H><G><Y><R><V><Q><V><E><N><P><E><R><F><S><S><A><P><C><L><L><G><S><R><V><F><S><Q><G><S><H><A><W><E><V><A><L><G><G><L><Q><S><W><R><V><G><V><V><R><V><R><Q><D><S><G><A><E><G><H><S><H><S><C><Y><H><D><T><R><S><G><F><W><Y><V><C><R><T><Q><G><V><E><G><D><H><C><V><T><S><D><P><A><T><S><P><L><V><L><A><I><P><R><R><L><R><V><E><L><E><C><E><E><G><E><L><S><F><Y><D><A><E><R><H><C><H><L><Y><T><F><H><A><R><F><G><E><V><R><P><Y><F><Y><L><G><G><A><R><G><A><G><P><P><E><P><L><R><I><C><P><L><H><I><S><V><K><E><E><L><D><G>
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via DDX58/RIG-I signaling pathway . Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 . Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway . Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth .<BOP>
Q9UPQ4
O43148
MCES_HUMAN
mRNA cap methyltransferase
Homo
<M><A><N><S><A><K><A><E><E><Y><E><K><M><S><L><E><Q><A><K><A><S><V><N><S><E><T><E><S><S><F><N><I><N><E><N><T><T><A><S><G><T><G><L><S><E><K><T><S><V><C><R><Q><V><D><I><A><R><K><R><K><E><F><E><D><D><L><V><K><E><S><S><S><C><G><K><D><T><P><S><K><K><R><K><L><D><P><E><I><V><P><E><E><K><D><C><G><D><A><E><G><N><S><K><K><R><K><R><E><T><E><D><V><P><K><D><K><S><S><T><G><D><G><T><Q><N><K><R><K><I><A><L><E><D><V><P><E><K><Q><K><N><L><E><E><G><H><S><S><T><V><A><A><H><Y><N><E><L><Q><E><V><G><L><E><K><R><S><Q><S><R><I><F><Y><L><R><N><F><N><N><W><M><K><S><V><L><I><G><E><F><L><E><K><V><R><Q><K><K><K><R><D><I><T><V><L><D><L><G><C><G><K><G><G><D><L><L><K><W><K><K><G><R><I><N><K><L><V><C><T><D><I><A><D><V><S><V><K><Q><C><Q><Q><R><Y><E><D><M><K><N><R><R><D><S><E><Y><I><F><S><A><E><F><I><T><A><D><S><S><K><E><L><L><I><D><K><F><R><D><P><Q><M><C><F><D><I><C><S><C><Q><F><V><C><H><Y><S><F><E><S><Y><E><Q><A><D><M><M><L><R><N><A><C><E><R><L><S><P><G><G><Y><F><I><G><T><T><P><N><S><F><E><L><I><R><R><L><E><A><S><E><T><E><S><F><G><N><E><I><Y><T><V><K><F><Q><K><K><G><D><Y><P><L><F><G><C><K><Y><D><F><N><L><E><G><V><V><D><V><P><E><F><L><V><Y><F><P><L><L><N><E><M><A><K><K><Y><N><M><K><L><V><Y><K><K><T><F><L><E><F><Y><E><E><K><I><K><N><N><E><N><K><M><L><L><K><R><M><Q><A><L><E><P><Y><P><A><N><E><S><S><K><L><V><S><E><K><V><D><D><Y><E><H><A><A><K><Y><M><K><N><S><Q><V><R><L><P><L><G><T><L><S><K><S><E><W><E><A><T><S><I><Y><L><V><F><A><F><E><K><Q><Q>
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs . Binds RNA containing 5'-terminal GpppC .<BOP>
O43148
A8MXU0
DB108_HUMAN
Putative beta-defensin 108B pseudogene 1/2
Homo
<M><R><I><A><V><L><F><F><T><I><F><F><F><M><S><Q><V><L><P><A><K><G><K><F><K><E><I><C><E><R><P><N><G><S><C><R><D><F><C><L><E><T><E><I><H><V><G><R><C><L><N><S><R><P><C><C><L><P><L><G><H><Q><P><R><I><E><S><T><T><P><K><K><D>
Has antibacterial activity.<BOP>
A8MXU0