accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q9H0R1
AP5M1_HUMAN
Putative HIV-1 infection-related protein
Homo
<M><A><Q><R><A><V><W><L><I><S><H><E><P><G><T><P><L><C><G><T><V><R><F><S><R><R><Y><P><T><V><E><K><R><A><R><V><F><N><G><A><S><Y><V><P><V><P><E><D><G><P><F><L><K><A><L><L><F><E><L><R><L><L><D><D><D><K><D><F><V><E><S><R><D><S><C><S><R><I><N><K><T><S><I><Y><G><L><L><I><G><G><E><E><L><W><P><V><V><A><F><L><K><N><D><M><I><Y><A><C><V><P><L><V><E><Q><T><L><S><P><R><P><P><L><I><S><V><S><G><V><S><Q><G><F><E><F><L><F><G><I><Q><D><F><L><Y><S><G><Q><K><N><D><S><E><L><N><T><K><L><S><Q><L><P><D><L><L><L><Q><A><C><P><F><G><T><L><L><D><A><N><L><Q><N><S><L><D><N><T><N><F><A><S><V><T><Q><P><Q><K><Q><P><A><W><K><T><G><T><Y><K><G><K><P><Q><V><S><I><S><I><T><E><K><V><K><S><M><Q><Y><D><K><Q><G><I><A><D><T><W><Q><V><V><G><T><V><T><C><K><C><D><L><E><G><I><M><P><N><V><T><I><S><L><S><L><P><T><N><G><S><P><L><Q><D><I><L><V><H><P><C><V><T><S><L><D><S><A><I><L><T><S><S><S><I><D><A><M><D><D><S><A><F><S><G><P><Y><K><F><P><F><T><P><P><L><E><S><F><N><L><C><F><Y><T><S><Q><V><P><V><P><P><I><L><G><F><Y><Q><M><K><E><E><E><V><Q><L><R><I><T><I><N><L><K><L><H><E><S><V><K><N><N><F><E><F><C><E><A><H><I><P><F><Y><N><R><G><P><I><T><H><L><E><Y><K><T><S><F><G><Q><L><E><V><F><R><E><K><S><L><L><I><W><I><I><G><Q><K><F><P><K><S><M><E><I><S><L><S><G><T><V><T><F><G><A><K><S><H><E><K><Q><P><F><D><P><I><C><T><G><E><T><A><Y><L><K><L><H><F><R><I><L><D><Y><T><L><T><G><C><Y><A><D><Q><H><S><V><Q><V><F><A><S><G><K><P><K><I><S><A><H><R><K><L><I><S><S><D><Y><Y><I><W><N><S><K><A><P><A><P><V><T><Y><G><S><L><L><L>
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.<BOP>
Q9H0R1
Q9BZ23
PANK2_HUMAN
Pantothenate kinase 2, mitochondrial mature form
Homo
<M><R><R><L><G><P><F><H><P><R><V><H><W><A><A><P><P><S><L><S><S><G><L><H><R><L><L><F><L><R><G><T><R><I><P><S><S><T><T><L><S><P><P><R><H><D><S><L><S><L><D><G><G><T><V><N><P><P><R><V><R><E><P><T><G><R><E><A><F><G><P><S><P><A><S><S><D><W><L><P><A><R><W><R><N><G><R><G><G><R><P><R><A><R><L><C><S><G><W><T><A><A><E><E><A><R><R><N><P><T><L><G><G><L><L><G><R><Q><R><L><L><L><R><M><G><G><G><R><L><G><A><P><M><E><R><H><G><R><A><S><A><T><S><V><S><S><A><G><E><Q><A><A><G><D><P><E><G><R><R><Q><E><P><L><R><R><R><A><S><S><A><S><V><P><A><V><G><A><S><A><E><G><T><R><R><D><R><L><G><S><Y><S><G><P><T><S><V><S><R><Q><R><V><E><S><L><R><K><K><R><P><L><F><P><W><F><G><L><D><I><G><G><T><L><V><K><L><V><Y><F><E><P><K><D><I><T><A><E><E><E><E><E><E><V><E><S><L><K><S><I><R><K><Y><L><T><S><N><V><A><Y><G><S><T><G><I><R><D><V><H><L><E><L><K><D><L><T><L><C><G><R><K><G><N><L><H><F><I><R><F><P><T><H><D><M><P><A><F><I><Q><M><G><R><D><K><N><F><S><S><L><H><T><V><F><C><A><T><G><G><G><A><Y><K><F><E><Q><D><F><L><T><I><G><D><L><Q><L><C><K><L><D><E><L><D><C><L><I><K><G><I><L><Y><I><D><S><V><G><F><N><G><R><S><Q><C><Y><Y><F><E><N><P><A><D><S><E><K><C><Q><K><L><P><F><D><L><K><N><P><Y><P><L><L><L><V><N><I><G><S><G><V><S><I><L><A><V><Y><S><K><D><N><Y><K><R><V><T><G><T><S><L><G><G><G><T><F><F><G><L><C><C><L><L><T><G><C><T><T><F><E><E><A><L><E><M><A><S><R><G><D><S><T><K><V><D><K><L><V><R><D><I><Y><G><G><D><Y><E><R><F><G><L><P><G><W><A><V><A><S><S><F><G><N><M><M><S><K><E><K><R><E><A><V><S><K><E><D><L><A><R><A><T><L><I><T><I><T><N><N><I><G><S><I><A><R><M><C><A><L><N><E><N><I><N><Q><V><V><F><V><G><N><F><L><R><I><N><T><I><A><M><R><L><L><A><Y><A><L><D><Y><W><S><K><G><Q><L><K><A><L><F><S><E><H><E><G><Y><F><G><A><V><G><A><L><L><E><L><L><K><I><P>
Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.<BOP>
Q9BZ23
Q8NH63
O51H1_HUMAN
Olfactory receptor OR11-25
Homo
<M><T><N><L><N><A><S><Q><A><N><H><R><N><F><I><L><T><G><I><P><G><T><P><D><K><N><P><W><L><A><F><P><L><G><F><L><Y><T><L><T><L><L><G><N><G><T><I><L><A><V><I><K><V><E><P><S><L><H><E><P><T><Y><Y><F><L><S><I><L><A><L><T><D><V><S><L><S><M><S><T><L><P><S><M><L><S><I><Y><W><F><N><A><P><Q><I><V><F><D><A><C><I><M><Q><M><F><F><I><H><V><F><G><I><V><E><S><G><V><L><V><S><M><A><F><D><R><F><V><A><I><R><N><P><L><H><Y><V><S><I><L><T><H><D><V><I><R><K><T><G><I><A><V><L><T><R><A><V><C><V><V><F><P><V><P><F><L><I><K><C><L><P><F><C><H><S><N><V><L><S><H><S><Y><C><L><H><Q><N><M><M><R><L><A><C><A><S><T><R><I><N><S><L><Y><G><L><I><V><V><I><F><T><L><G><L><D><V><L><L><T><L><L><S><Y><V><L><T><L><K><T><V><L><G><I><V><S><R><G><E><R><L><K><T><L><S><T><C><L><S><H><M><S><T><V><L><L><F><Y><V><P><F><M><G><A><A><S><M><I><H><R><F><W><E><H><L><S><P><V><V><H><M><V><M><A><D><I><Y><L><L><L><P><P><V><L><N><P><I><V><Y><S><V><K><T><K><Q><I>
Odorant receptor.<BOP>
Q8NH63
O43680
TCF21_HUMAN
Podocyte-expressed 1
Homo
<M><S><T><G><S><L><S><D><V><E><D><L><Q><E><V><E><M><L><E><C><D><G><L><K><M><D><S><N><K><E><F><V><T><S><N><E><S><T><E><E><S><S><N><C><E><N><G><S><P><Q><K><G><R><G><G><L><G><K><R><R><K><A><P><T><K><K><S><P><L><S><G><V><S><Q><E><G><K><Q><V><Q><R><N><A><A><N><A><R><E><R><A><R><M><R><V><L><S><K><A><F><S><R><L><K><T><T><L><P><W><V><P><P><D><T><K><L><S><K><L><D><T><L><R><L><A><S><S><Y><I><A><H><L><R><Q><I><L><A><N><D><K><Y><E><N><G><Y><I><H><P><V><N><L><T><W><P><F><M><V><A><G><K><P><E><S><D><L><K><E><V><V><T><A><S><R><L><C><G><T><T><A><S>
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.<BOP>
O43680
Q76EJ3
S35D2_HUMAN
UDP-galactose transporter-related protein 8
Homo
<M><T><A><G><G><Q><A><E><A><E><G><A><G><G><E><P><G><A><A><R><L><P><S><R><V><A><R><L><L><S><A><L><F><Y><G><T><C><S><F><L><I><V><L><V><N><K><A><L><L><T><T><Y><G><F><P><S><P><I><F><L><G><I><G><Q><M><A><A><T><I><M><I><L><Y><V><S><K><L><N><K><I><I><H><F><P><D><F><D><K><K><I><P><V><K><L><F><P><L><P><L><L><Y><V><G><N><H><I><S><G><L><S><S><T><S><K><L><S><L><P><M><F><T><V><L><R><K><F><T><I><P><L><T><L><L><L><E><T><I><I><L><G><K><Q><Y><S><L><N><I><I><L><S><V><F><A><I><I><L><G><A><F><I><A><A><G><S><D><L><A><F><N><L><E><G><Y><I><F><V><F><L><N><D><I><F><T><A><A><N><G><V><Y><T><K><Q><K><M><D><P><K><E><L><G><K><Y><G><V><L><F><Y><N><A><C><F><M><I><I><P><T><L><I><I><S><V><S><T><G><D><L><Q><Q><A><T><E><F><N><Q><W><K><N><V><V><F><I><L><Q><F><L><L><S><C><F><L><G><F><L><L><M><Y><S><T><V><L><C><S><Y><Y><N><S><A><L><T><T><A><V><V><G><A><I><K><N><V><S><V><A><Y><I><G><I><L><I><G><G><D><Y><I><F><S><L><L><N><F><V><G><L><N><I><C><M><A><G><G><L><R><Y><S><F><L><T><L><S><S><Q><L><K><P><K><P><V><G><E><E><N><I><C><L><D><L><K><S>
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.<BOP>
Q76EJ3
O14791
APOL1_HUMAN
Apolipoprotein L-I
Homo
<M><E><G><A><A><L><L><R><V><S><V><L><C><I><W><M><S><A><L><F><L><G><V><G><V><R><A><E><E><A><G><A><R><V><Q><Q><N><V><P><S><G><T><D><T><G><D><P><Q><S><K><P><L><G><D><W><A><A><G><T><M><D><P><E><S><S><I><F><I><E><D><A><I><K><Y><F><K><E><K><V><S><T><Q><N><L><L><L><L><L><T><D><N><E><A><W><N><G><F><V><A><A><A><E><L><P><R><N><E><A><D><E><L><R><K><A><L><D><N><L><A><R><Q><M><I><M><K><D><K><N><W><H><D><K><G><Q><Q><Y><R><N><W><F><L><K><E><F><P><R><L><K><S><E><L><E><D><N><I><R><R><L><R><A><L><A><D><G><V><Q><K><V><H><K><G><T><T><I><A><N><V><V><S><G><S><L><S><I><S><S><G><I><L><T><L><V><G><M><G><L><A><P><F><T><E><G><G><S><L><V><L><L><E><P><G><M><E><L><G><I><T><A><A><L><T><G><I><T><S><S><T><M><D><Y><G><K><K><W><W><T><Q><A><Q><A><H><D><L><V><I><K><S><L><D><K><L><K><E><V><R><E><F><L><G><E><N><I><S><N><F><L><S><L><A><G><N><T><Y><Q><L><T><R><G><I><G><K><D><I><R><A><L><R><R><A><R><A><N><L><Q><S><V><P><H><A><S><A><S><R><P><R><V><T><E><P><I><S><A><E><S><G><E><Q><V><E><R><V><N><E><P><S><I><L><E><M><S><R><G><V><K><L><T><D><V><A><P><V><S><F><F><L><V><L><D><V><V><Y><L><V><Y><E><S><K><H><L><H><E><G><A><K><S><E><T><A><E><E><L><K><K><V><A><Q><E><L><E><E><K><L><N><I><L><N><N><N><Y><K><I><L><Q><A><D><Q><E><L>
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.<BOP>
O14791
Q96EP9
NTCP4_HUMAN
Solute carrier family 10 member 4
Homo
<M><D><G><N><D><N><V><T><L><L><F><A><P><L><L><R><D><N><Y><T><L><A><P><N><A><S><S><L><G><P><G><T><D><L><A><L><A><P><A><S><S><A><G><P><G><P><G><L><S><L><G><P><G><P><S><F><G><F><S><P><G><P><T><P><T><P><E><P><T><T><S><G><L><A><G><G><A><A><S><H><G><P><S><P><F><P><R><P><W><A><P><H><A><L><P><F><W><D><T><P><L><N><H><G><L><N><V><F><V><G><A><A><L><C><I><T><M><L><G><L><G><C><T><V><D><V><N><H><F><G><A><H><V><R><R><P><V><G><A><L><L><A><A><L><C><Q><F><G><L><L><P><L><L><A><F><L><L><A><L><A><F><K><L><D><E><V><A><A><V><A><V><L><L><C><G><C><C><P><G><G><N><L><S><N><L><M><S><L><L><V><D><G><D><M><N><L><S><I><I><M><T><I><S><S><T><L><L><A><L><V><L><M><P><L><C><L><W><I><Y><S><W><A><W><I><N><T><P><I><V><Q><L><L><P><L><G><T><V><T><L><T><L><C><S><T><L><I><P><I><G><L><G><V><F><I><R><Y><K><Y><S><R><V><A><D><Y><I><V><K><V><S><L><W><S><L><L><V><T><L><V><V><L><F><I><M><T><G><T><M><L><G><P><E><L><L><A><S><I><P><A><A><V><Y><V><I><A><I><F><M><P><L><A><G><Y><A><S><G><Y><G><L><A><T><L><F><H><L><P><P><N><C><K><R><T><V><C><L><E><T><G><S><Q><N><V><Q><L><C><T><A><I><L><K><L><A><F><P><P><Q><F><I><G><S><M><Y><M><F><P><L><L><Y><A><L><F><Q><S><A><E><A><G><I><F><V><L><I><Y><K><M><Y><G><S><E><M><L><H><K><R><D><P><L><D><E><D><E><D><T><D><I><S><Y><K><K><L><K><E><E><E><M><A><D><T><S><Y><G><T><V><K><A><E><N><I><I><M><M><E><T><A><Q><T><S><L>
Transporter for bile acids.<BOP>
Q96EP9
Q969Z0
FAKD4_HUMAN
Transforming growth factor beta regulator 4
Homo
<M><A><A><H><L><V><K><R><C><T><C><L><L><R><E><A><A><R><Q><A><P><A><M><A><P><V><G><R><L><R><L><A><W><V><A><H><K><T><L><T><S><S><A><T><S><P><I><S><H><L><P><G><S><L><M><E><P><V><E><K><E><R><A><S><T><P><Y><I><E><K><Q><V><D><H><L><I><K><K><A><T><R><P><E><E><L><L><E><L><L><G><G><S><H><D><L><D><S><N><Q><A><A><M><V><L><I><R><L><S><H><L><L><S><E><K><P><E><D><K><G><L><L><I><Q><D><A><H><F><H><Q><L><L><C><L><L><N><S><Q><I><A><S><V><W><H><G><T><L><S><K><L><L><G><S><L><Y><A><L><G><I><P><K><A><S><K><E><L><Q><S><V><E><Q><E><V><R><W><R><M><R><K><L><K><Y><K><H><L><A><F><L><A><E><S><C><A><T><L><S><Q><E><Q><H><S><Q><E><L><L><A><E><L><L><T><H><L><E><R><R><W><T><E><I><E><D><S><H><T><L><V><T><V><M><M><K><V><G><H><L><S><E><P><L><M><N><R><L><E><D><K><C><L><E><L><V><E><H><F><G><P><N><E><L><R><K><V><L><V><M><L><A><A><Q><S><R><R><S><V><P><L><L><R><A><I><S><Y><H><L><V><Q><K><P><F><S><L><T><K><D><V><L><L><D><V><A><Y><A><Y><G><K><L><S><F><H><Q><T><Q><V><S><Q><R><L><A><T><D><L><L><S><L><M><P><S><L><T><S><G><E><V><A><H><C><A><K><S><F><A><L><L><K><W><L><S><L><P><L><F><E><A><F><A><Q><H><V><L><N><R><A><Q><D><I><T><L><P><H><L><C><S><V><L><L><A><F><A><R><L><N><F><H><P><D><Q><E><D><Q><F><F><S><L><V><H><E><K><L><G><S><E><L><P><G><L><E><P><A><L><Q><V><D><L><V><W><A><L><C><V><L><Q><Q><A><R><E><A><E><L><Q><A><V><L><H><P><E><F><H><I><Q><F><L><G><G><K><S><Q><K><D><Q><N><T><F><Q><K><L><L><H><I><N><A><T><A><L><L><E><Y><P><E><Y><S><G><P><L><L><P><A><S><A><V><A><P><G><P><S><A><L><D><R><K><V><T><P><L><Q><K><E><L><Q><E><T><L><K><G><L><L><G><S><A><D><K><G><S><L><E><V><A><T><Q><Y><G><W><V><L><D><A><E><V><L><L><D><S><D><G><E><F><L><P><V><R><D><F><V><A><P><H><L><A><Q><P><T><G><S><Q><S><P><P><P><G><S><K><R><L><A><F><L><R><W><E><F><P><N><F><N><S><R><S><K><D><L><L><G><R><F><V><L><A><R><R><H><I><V><A><A><G><F><L><I><V><D><V><P><F><Y><E><W><L><E><L><K><S><E><W><Q><K><G><A><Y><L><K><D><K><M><R><K><A><V><A><E><E><L><A><K>
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression .<BOP>
Q969Z0
O14713
ITBP1_HUMAN
Integrin cytoplasmic domain-associated protein 1
Homo
<M><F><R><K><G><K><K><R><H><S><S><S><S><S><Q><S><S><E><I><S><T><K><S><K><S><V><D><S><S><L><G><G><L><S><R><S><S><T><V><A><S><L><D><T><D><S><T><K><S><S><G><Q><S><N><N><N><S><D><T><C><A><E><F><R><I><K><Y><V><G><A><I><E><K><L><K><L><S><E><G><K><G><L><E><G><P><L><D><L><I><N><Y><I><D><V><A><Q><Q><D><G><K><L><P><F><V><P><P><E><E><E><F><I><M><G><V><S><K><Y><G><I><K><V><S><T><S><D><Q><Y><D><V><L><H><R><H><A><L><Y><L><I><I><R><M><V><C><Y><D><D><G><L><G><A><G><K><S><L><L><A><L><K><T><T><D><A><S><N><E><E><Y><S><L><W><V><Y><Q><C><N><S><L><E><Q><A><Q><A><I><C><K><V><L><S><T><A><F><D><S><V><L><T><S><E><K><P>
Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytopl
O14713
P52757
CHIO_HUMAN
Rho GTPase-activating protein 3
Homo
<M><A><A><S><S><N><S><S><L><S><G><S><S><V><S><S><D><A><E><E><Y><Q><P><P><I><W><K><S><Y><L><Y><Q><L><Q><Q><E><A><P><R><P><K><R><I><I><C><P><R><E><V><E><N><R><P><K><Y><Y><G><R><E><F><H><G><I><I><S><R><E><Q><A><D><E><L><L><G><G><V><E><G><A><Y><I><L><R><E><S><Q><R><Q><P><G><C><Y><T><L><A><L><R><F><G><N><Q><T><L><N><Y><R><L><F><H><D><G><K><H><F><V><G><E><K><R><F><E><S><I><H><D><L><V><T><D><G><L><I><T><L><Y><I><E><T><K><A><A><E><Y><I><S><K><M><T><T><N><P><I><Y><E><H><I><G><Y><A><T><L><L><R><E><K><V><S><R><R><L><S><R><S><K><N><E><P><R><K><T><N><V><T><H><E><E><H><T><A><V><E><K><I><S><S><L><V><R><R><A><A><L><T><H><N><D><N><H><F><N><Y><E><K><T><H><N><F><K><V><H><T><F><R><G><P><H><W><C><E><Y><C><A><N><F><M><W><G><L><I><A><Q><G><V><R><C><S><D><C><G><L><N><V><H><K><Q><C><S><K><H><V><P><N><D><C><Q><P><D><L><K><R><I><K><K><V><Y><C><C><D><L><T><T><L><V><K><A><H><N><T><Q><R><P><M><V><V><D><I><C><I><R><E><I><E><A><R><G><L><K><S><E><G><L><Y><R><V><S><G><F><T><E><H><I><E><D><V><K><M><A><F><D><R><D><G><E><K><A><D><I><S><A><N><V><Y><P><D><I><N><I><I><T><G><A><L><K><L><Y><F><R><D><L><P><I><P><V><I><T><Y><D><T><Y><S><K><F><I><D><A><A><K><I><S><N><A><D><E><R><L><E><A><V><H><E><V><L><M><L><L><P><P><A><H><Y><E><T><L><R><Y><L><M><I><H><L><K><K><V><T><M><N><E><K><D><N><F><M><N><A><E><N><L><G><I><V><F><G><P><T><L><M><R><P><P><E><D><S><T><L><T><T><L><H><D><M><R><Y><Q><K><L><I><V><Q><I><L><I><E><N><E><D><V><L><F>
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.<BOP>
P52757
Q96N58
ZN578_HUMAN
Zinc finger protein 578
Homo
<M><L><H><E><E><A><A><Q><K><R><K><G><K><E><P><G><M><A><L><P><Q><G><R><L><T><F><R><D><V><A><I><E><F><S><L><A><E><W><K><F><L><N><P><A><Q><R><A><L><Y><R><E><V><M><L><E><N><Y><R><N><L><E><A><V><D><I><S><S><K><R><M><M><K><E><V><L><S><T><G><Q><G><N><T><E><V><I><H><T><G><M><L><Q><R><H><E><S><Y><H><T><G><D><F><C><F><Q><E><I><E><K><D><I><H><D><F><E><F><Q><S><Q><K><D><E><R><N><G><H><E><A><S><M><P><K><I><K><E><L><M><G><S><T><D><R><H><D><Q><R><H><A><G><N><K><P><I><K><D><Q><L><G><L><S><F><H><L><H><L><P><E><L><H><I><F><Q><P><E><E><K><I><A><N><Q><V><E><K><S><V><N><D><A><S><S><I><S><T><S><Q><R><I><S><C><R><P><E><T><H><T><P><N><N><Y><G><N><N><F><F><H><S><S><L><L><T><Q><K><Q><E><V><H><M><R><E><K><S><F><Q><C><N><E><T><G><E><A><F><N><C><S><S><F><V><R><K><H><Q><I><I><H><L><G><E><K><Q><Y><K><F><D><I><C><G><K><V><F><N><E><K><R><Y><L><A><R><H><R><R><C><H><T><S><E><K><P><Y><K><C><N><E><C><G><K><S><F><S><Y><K><S><S><L><T><C><H><R><R><C><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><S><F><S><Y><K><S><S><L><T><C><H><H><R><C><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><S><F><S><Y><K><S><S><L><R><C><H><R><R><L><H><T><G><I><K><P><Y><K><C><N><E><C><G><K><M><F><G><Q><N><S><T><L><V><I><H><K><A><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><N><Q><Q><S><H><L><S><R><H><H><R><L><H><T><G><E><K><P><Y><K><C><N><D><C><G><K><A><F><I><H><Q><S><S><L><A><R><H><H><R><L><H><T><G><E><K><S><Y><K><C><E><E><C><D><R><V><F><S><Q><K><S><N><L><E><R><H><K><I><I><H><T><G><E><K><P><Y><K><C><N><E><C><H><K><T><F><S><H><R><S><S><L><P><C><H><R><R><L><H><S><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><N><V><Q><S><H><L><S><R><H><H><R><L><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><M><C><H><S><Y><L><A><N><H><T><R><I><H><S><G><E><K><P><Y><K><C><N><E><C><G><K><A><H><N><H><L><I><D><S><S><I><K><P><C><M><S><S>
May be involved in transcriptional regulation.<BOP>
Q96N58
Q8NH80
O10D3_HUMAN
Olfactory receptor OR11-293
Homo
<M><E><V><K><N><C><C><M><V><T><E><F><I><L><L><G><I><P><H><T><E><G><L><E><M><T><L><F><V><L><F><L><P><F><Y><A><C><T><L><L><G><N><V><S><I><L><V><A><V><M><S><S><A><R><L><H><T><P><M><Y><F><F><L><G><N><L><S><V><F><D><M><G><F><S><S><V><T><C><P><K><M><L><L><Y><L><M><G><L><S><R><L><I><S><Y><K><D><C><V><C><Q><L><F><F><F><H><F><L><G><S><I><E><C><F><L><F><T><V><M><A><Y><D><R><F><T><A><I><C><Y><P><L><R><Y><T><V><I><M><N><P><R><I><C><V><A><L><A><V><G><T><W><L><L><G><C><I><H><S><S><I><L><T><S><L><T><F><T><L><P><Y><C><G><P><N><E><V><D><H><F><F><C><D><I><P><A><L><L><P><L><A><C><A><D><T><S><L><A><Q><R><V><S><F><T><N><V><G><L><I><S><L><V><C><F><L><L><I><L><L><S><Y><T><R><I><T><I><S><I><L><S><I><R><T><T><E><G><R><R><R><A><F><S><T><C><S><A><H><L><I><A><I><L><C><A><Y><G><P><I><I><T><V><Y><L><Q><P><T><P><N><P><M><L><G><T><V><V><Q><I><L><M><N><L><V><G><P><M><L><N><P><L><I><Y><T><L><R><N><K><E><V><K><T><A><L><K><T><I><L><H><R><T><G><H><V><P><E><S>
Odorant receptor.<BOP>
Q8NH80
Q96PN8
TSSK3_HUMAN
Serine/threonine-protein kinase 22C
Homo
<M><E><D><F><L><L><S><N><G><Y><Q><L><G><K><T><I><G><E><G><T><Y><S><K><V><K><E><A><F><S><K><K><H><Q><R><K><V><A><I><K><V><I><D><K><M><G><G><P><E><E><F><I><Q><R><F><L><P><R><E><L><Q><I><V><R><T><L><D><H><K><N><I><I><Q><V><Y><E><M><L><E><S><A><D><G><K><I><C><L><V><M><E><L><A><E><G><G><D><V><F><D><C><V><L><N><G><G><P><L><P><E><S><R><A><K><A><L><F><R><Q><M><V><E><A><I><R><Y><C><H><G><C><G><V><A><H><R><D><L><K><C><E><N><A><L><L><Q><G><F><N><L><K><L><T><D><F><G><F><A><K><V><L><P><K><S><H><R><E><L><S><Q><T><F><C><G><S><T><A><Y><A><A><P><E><V><L><Q><G><I><P><H><D><S><K><K><G><D><V><W><S><M><G><V><V><L><Y><V><M><L><C><A><S><L><P><F><D><D><T><D><I><P><K><M><L><W><Q><Q><Q><K><G><V><S><F><P><T><H><L><S><I><S><A><D><C><Q><D><L><L><K><R><L><L><E><P><D><M><I><L><R><P><S><I><E><E><V><S><W><H><P><W><L><A><S><T>
May be involved in a signaling pathway during male germ cell development or mature sperm function.<BOP>
Q96PN8
P81277
PRRP_HUMAN
Prolactin-releasing peptide PrRP20
Homo
<M><K><V><L><R><A><W><L><L><C><L><L><M><L><G><L><A><L><R><G><A><A><S><R><T><H><R><H><S><M><E><I><R><T><P><D><I><N><P><A><W><Y><A><S><R><G><I><R><P><V><G><R><F><G><R><R><R><A><T><L><G><D><V><P><K><P><G><L><R><P><R><L><T><C><F><P><L><E><G><G><A><M><S><S><Q><D><G>
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.<BOP>
P81277
O75351
VPS4B_HUMAN
Suppressor of K(+) transport growth defect 1
Homo
<M><S><S><T><S><P><N><L><Q><K><A><I><D><L><A><S><K><A><A><Q><E><D><K><A><G><N><Y><E><E><A><L><Q><L><Y><Q><H><A><V><Q><Y><F><L><H><V><V><K><Y><E><A><Q><G><D><K><A><K><Q><S><I><R><A><K><C><T><E><Y><L><D><R><A><E><K><L><K><E><Y><L><K><N><K><E><K><K><A><Q><K><P><V><K><E><G><Q><P><S><P><A><D><E><K><G><N><D><S><D><G><E><G><E><S><D><D><P><E><K><K><K><L><Q><N><Q><L><Q><G><A><I><V><I><E><R><P><N><V><K><W><S><D><V><A><G><L><E><G><A><K><E><A><L><K><E><A><V><I><L><P><I><K><F><P><H><L><F><T><G><K><R><T><P><W><R><G><I><L><L><F><G><P><P><G><T><G><K><S><Y><L><A><K><A><V><A><T><E><A><N><N><S><T><F><F><S><I><S><S><S><D><L><V><S><K><W><L><G><E><S><E><K><L><V><K><N><L><F><Q><L><A><R><E><N><K><P><S><I><I><F><I><D><E><I><D><S><L><C><G><S><R><S><E><N><E><S><E><A><A><R><R><I><K><T><E><F><L><V><Q><M><Q><G><V><G><V><D><N><D><G><I><L><V><L><G><A><T><N><I><P><W><V><L><D><S><A><I><R><R><R><F><E><K><R><I><Y><I><P><L><P><E><P><H><A><R><A><A><M><F><K><L><H><L><G><T><T><Q><N><S><L><T><E><A><D><F><R><E><L><G><R><K><T><D><G><Y><S><G><A><D><I><S><I><I><V><R><D><A><L><M><Q><P><V><R><K><V><Q><S><A><T><H><F><K><K><V><R><G><P><S><R><A><D><P><N><H><L><V><D><D><L><L><T><P><C><S><P><G><D><P><G><A><I><E><M><T><W><M><D><V><P><G><D><K><L><L><E><P><V><V><S><M><S><D><M><L><R><S><L><S><N><T><K><P><T><V><N><E><H><D><L><L><K><L><K><K><F><T><E><D><F><G><Q><E><G>
(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).<BOP>
O75351
Q8IUE0
TF2LY_HUMAN
TGIF-like on the Y
Homo
<M><E><A><A><A><D><G><P><A><E><T><Q><S><P><V><E><K><D><S><P><A><K><T><Q><S><P><A><Q><D><T><S><I><M><S><R><N><N><A><D><T><G><R><V><L><A><L><P><E><H><K><K><K><R><K><G><N><L><P><A><E><S><V><K><I><L><R><D><W><M><Y><K><H><R><F><K><A><Y><P><S><E><E><E><K><Q><M><L><S><E><K><T><N><L><S><L><L><R><I><S><N><W><F><I><N><A><R><R><R><I><L><P><D><M><L><Q><Q><R><R><N><D><P><I><I><G><H><K><T><G><K><D><A><H><A><T><H><L><Q><S><T><E><A><S><V><P><A><K><S><G><P><V><V><Q><T><M><Y><K><A><C><P><C><G><P><C><Q><R><A><R><C><Q><E><R><S><N><Q><I><R><S><R><P><L><A><R><S><S><P><E>
May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX.<BOP>
Q8IUE0
P19429
TNNI3_HUMAN
Cardiac troponin I
Homo
<M><A><D><G><S><S><D><A><A><R><E><P><R><P><A><P><A><P><I><R><R><R><S><S><N><Y><R><A><Y><A><T><E><P><H><A><K><K><K><S><K><I><S><A><S><R><K><L><Q><L><K><T><L><L><L><Q><I><A><K><Q><E><L><E><R><E><A><E><E><R><R><G><E><K><G><R><A><L><S><T><R><C><Q><P><L><E><L><A><G><L><G><F><A><E><L><Q><D><L><C><R><Q><L><H><A><R><V><D><K><V><D><E><E><R><Y><D><I><E><A><K><V><T><K><N><I><T><E><I><A><D><L><T><Q><K><I><F><D><L><R><G><K><F><K><R><P><T><L><R><R><V><R><I><S><A><D><A><M><M><Q><A><L><L><G><A><R><A><K><E><S><L><D><L><R><A><H><L><K><Q><V><K><K><E><D><T><E><K><E><N><R><E><V><G><D><W><R><K><N><I><D><A><L><S><G><M><E><G><R><K><K><K><F><E><S>
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.<BOP>
P19429
Q6NTE8
MRNIP_HUMAN
MRN-interacting protein
Homo
<M><A><S><L><Q><R><S><R><V><L><R><C><C><S><C><R><L><F><Q><A><H><Q><V><K><K><S><V><K><W><T><C><K><A><C><G><E><K><Q><S><F><L><Q><A><Y><G><E><G><S><G><A><D><C><R><R><H><V><Q><K><L><N><L><L><Q><G><Q><V><S><E><L><P><L><R><S><L><E><E><T><V><S><A><S><E><E><E><N><V><G><H><Q><Q><A><G><N><V><K><Q><Q><E><K><S><Q><P><S><E><S><R><W><L><K><Y><L><E><K><D><S><Q><E><L><E><L><E><G><T><G><V><C><F><S><K><Q><P><S><S><K><M><E><E><P><G><P><R><F><S><Q><D><L><P><R><K><R><K><W><S><R><S><T><V><Q><P><P><C><S><R><G><V><Q><D><S><G><G><S><E><V><A><W><G><P><Q><K><G><Q><A><G><L><T><W><K><V><K><Q><G><S><S><P><C><L><Q><E><N><S><A><D><C><S><A><G><E><L><R><G><P><G><K><E><L><W><S><P><I><Q><Q><V><T><A><T><S><S><K><W><A><Q><F><V><L><P><P><R><K><S><S><H><V><D><S><E><Q><P><R><S><L><Q><R><D><P><R><P><A><G><P><A><Q><A><K><Q><G><T><P><R><A><Q><A><S><R><E><G><L><S><R><P><T><A><A><V><Q><L><P><R><A><T><H><P><V><T><S><G><S><E><R><P><C><G><K><T><S><W><D><A><R><T><P><W><A><E><G><G><P><L><V><L><E><A><Q><N><P><R><P><T><R><L><C><D><L><F><I><T><G><E><D><F><D><D><D><V>
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex . Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair .<BOP>
Q6NTE8
Q16658
FSCN1_HUMAN
p55
Homo
<M><T><A><N><G><T><A><E><A><V><Q><I><Q><F><G><L><I><N><C><G><N><K><Y><L><T><A><E><A><F><G><F><K><V><N><A><S><A><S><S><L><K><K><K><Q><I><W><T><L><E><Q><P><P><D><E><A><G><S><A><A><V><C><L><R><S><H><L><G><R><Y><L><A><A><D><K><D><G><N><V><T><C><E><R><E><V><P><G><P><D><C><R><F><L><I><V><A><H><D><D><G><R><W><S><L><Q><S><E><A><H><R><R><Y><F><G><G><T><E><D><R><L><S><C><F><A><Q><T><V><S><P><A><E><K><W><S><V><H><I><A><M><H><P><Q><V><N><I><Y><S><V><T><R><K><R><Y><A><H><L><S><A><R><P><A><D><E><I><A><V><D><R><D><V><P><W><G><V><D><S><L><I><T><L><A><F><Q><D><Q><R><Y><S><V><Q><T><A><D><H><R><F><L><R><H><D><G><R><L><V><A><R><P><E><P><A><T><G><Y><T><L><E><F><R><S><G><K><V><A><F><R><D><C><E><G><R><Y><L><A><P><S><G><P><S><G><T><L><K><A><G><K><A><T><K><V><G><K><D><E><L><F><A><L><E><Q><S><C><A><Q><V><V><L><Q><A><A><N><E><R><N><V><S><T><R><Q><G><M><D><L><S><A><N><Q><D><E><E><T><D><Q><E><T><F><Q><L><E><I><D><R><D><T><K><K><C><A><F><R><T><H><T><G><K><Y><W><T><L><T><A><T><G><G><V><Q><S><T><A><S><S><K><N><A><S><C><Y><F><D><I><E><W><R><D><R><R><I><T><L><R><A><S><N><G><K><F><V><T><S><K><K><N><G><Q><L><A><A><S><V><E><T><A><G><D><S><E><L><F><L><M><K><L><I><N><R><P><I><I><V><F><R><G><E><H><G><F><I><G><C><R><K><V><T><G><T><L><D><A><N><R><S><S><Y><D><V><F><Q><L><E><F><N><D><G><A><Y><N><I><K><D><S><T><G><K><Y><W><T><V><G><S><D><S><A><V><T><S><S><G><D><T><P><V><D><F><F><F><E><F><C><D><Y><N><K><V><A><I><K><V><G><G><R><Y><L><K><G><D><H><A><G><V><L><K><A><S><A><E><T><V><D><P><A><S><L><W><E><Y>
Actin-binding protein that contains 2 major actin binding sites . Organizes filamentous actin into parallel bundles . Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers . Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration . Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF .<BOP>
Q16658
Q7Z5Y7
KCD20_HUMAN
Potassium channel tetramerization domain containing 20
Homo
<M><N><V><H><R><G><S><D><S><D><R><L><L><R><Q><E><A><S><C><L><V><D><D><T><L><A><V><A><Q><E><K><E><A><N><S><L><A><S><S><G><P><H><N><L><T><Y><P><L><G><P><R><N><E><D><L><S><L><D><Y><A><S><Q><P><A><N><L><Q><F><P><H><I><M><P><L><A><E><D><I><K><G><S><C><F><Q><S><G><N><K><R><N><H><E><P><F><I><A><P><E><R><F><G><N><S><S><V><G><F><G><S><N><S><H><S><Q><A><P><E><K><V><T><L><L><V><D><G><T><R><F><V><V><N><P><Q><I><F><T><A><H><P><D><T><M><L><G><R><M><F><G><P><G><R><E><Y><N><F><T><R><P><N><E><K><G><E><Y><E><I><A><E><G><I><S><A><T><V><F><R><T><V><L><D><Y><Y><K><T><G><I><I><N><C><P><D><G><I><S><I><P><D><L><R><D><T><C><D><Y><L><C><I><N><F><D><F><N><T><I><R><C><Q><D><L><S><A><L><L><H><E><L><S><N><D><G><A><H><K><Q><F><D><H><Y><L><E><E><L><I><L><P><I><M><V><G><C><A><K><K><G><E><R><E><C><H><I><V><V><L><T><D><E><D><S><V><D><W><D><E><D><H><P><P><P><M><G><E><E><Y><S><Q><I><L><Y><S><S><K><L><Y><R><F><F><K><Y><I><E><N><R><D><V><A><K><T><V><L><K><E><R><G><L><K><N><I><R><I><G><I><E><G><Y><P><T><C><K><E><K><I><K><R><R><P><G><G><R><S><E><V><I><Y><N><Y><V><Q><R><P><F><I><Q><M><S><W><E><K><E><E><G><K><S><R><H><V><D><F><Q><C><V><R><S><K><S><L><T><N><L><V><A><A><G><D><D><V><L><E><D><Q><E><I><L><M><H><H><P><P><Q><V><D><E><L><D><R><L><N><A><P><L><S><Q><M><A><S><N><D><F><Q><D>
Promotes the phosphorylation of AKT family members.<BOP>
Q7Z5Y7
P55082
MFAP3_HUMAN
Microfibril-associated glycoprotein 3
Homo
<M><K><L><H><C><C><L><F><T><L><V><A><S><I><I><V><P><A><A><F><V><L><E><D><V><D><F><D><Q><M><V><S><L><E><A><N><R><S><S><Y><N><A><S><F><P><S><S><F><E><L><S><A><S><S><H><S><D><D><D><V><I><I><A><K><E><G><T><S><V><S><I><E><C><L><L><T><A><S><H><Y><E><D><V><H><W><H><N><S><K><G><Q><Q><L><D><G><R><S><R><G><G><K><W><L><V><S><D><N><F><L><N><I><T><N><V><A><F><D><D><R><G><L><Y><T><C><F><V><T><S><P><I><R><A><S><Y><S><V><T><L><R><V><I><F><T><S><G><D><M><S><V><Y><Y><M><I><V><C><L><I><A><F><T><I><T><L><I><L><N><V><T><R><L><C><M><M><S><S><H><L><R><K><T><E><K><A><I><N><E><F><F><R><T><E><G><A><E><K><L><Q><K><A><F><E><I><A><K><R><I><P><I><I><T><S><A><K><T><L><E><L><A><K><V><T><Q><F><K><T><M><E><F><A><R><Y><I><E><E><L><A><R><S><V><P><L><P><P><L><I><L><N><C><R><A><F><V><E><E><M><F><E><A><V><R><V><D><D><P><D><D><L><G><E><R><I><K><E><R><P><A><L><N><A><Q><G><G><I><Y><V><I><N><P><E><M><G><R><S><N><S><P><G><G><D><S><D><D><G><S><L><N><E><Q><G><Q><E><I><A><V><Q><V><S><V><H><L><Q><S><E><T><K><S><I><D><T><E><S><Q><G><S><S><H><F><S><P><P><D><D><I><G><S><A><E><S><N><C><N><Y><K><D><G><A><Y><E><N><C><Q><L>
Component of the elastin-associated microfibrils.<BOP>
P55082
Q9BX68
HINT2_HUMAN
PKCI-1-related HIT protein
Homo
<M><A><A><A><V><V><L><A><A><G><L><R><A><A><R><R><A><V><A><A><T><G><V><R><G><G><Q><V><R><G><A><A><G><V><T><D><G><N><E><V><A><K><A><Q><Q><A><T><P><G><G><A><A><P><T><I><F><S><R><I><L><D><K><S><L><P><A><D><I><L><Y><E><D><Q><Q><C><L><V><F><R><D><V><A><P><Q><A><P><V><H><F><L><V><I><P><K><K><P><I><P><R><I><S><Q><A><E><E><E><D><Q><Q><L><L><G><H><L><L><L><V><A><K><Q><T><A><K><A><E><G><L><G><D><G><Y><R><L><V><I><N><D><G><K><L><G><A><Q><S><V><Y><H><L><H><I><H><V><L><G><G><R><Q><L><Q><W><P><P><G>
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 . Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) . Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro . May be involved in steroid biosynthesis . May play a role in apoptosis .<BOP>
Q9BX68
Q9Y2C3
B3GT5_HUMAN
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Homo
<M><A><F><P><K><M><R><L><M><Y><I><C><L><L><V><L><G><A><L><C><L><Y><F><S><M><Y><S><L><N><P><F><K><E><Q><S><F><V><Y><K><K><D><G><N><F><L><K><L><P><D><T><D><C><R><Q><T><P><P><F><L><V><L><L><V><T><S><S><H><K><Q><L><A><E><R><M><A><I><R><Q><T><W><G><K><E><R><M><V><K><G><K><Q><L><K><T><F><F><L><L><G><T><T><S><S><A><A><E><T><K><E><V><D><Q><E><S><Q><R><H><G><D><I><I><Q><K><D><F><L><D><V><Y><Y><N><L><T><L><K><T><M><M><G><I><E><W><V><H><R><F><C><P><Q><A><A><F><V><M><K><T><D><S><D><M><F><I><N><V><D><Y><L><T><E><L><L><L><K><K><N><R><T><T><R><F><F><T><G><F><L><K><L><N><E><F><P><I><R><Q><P><F><S><K><W><F><V><S><K><S><E><Y><P><W><D><R><Y><P><P><F><C><S><G><T><G><Y><V><F><S><G><D><V><A><S><Q><V><Y><N><V><S><K><S><V><P><Y><I><K><L><E><D><V><F><V><G><L><C><L><E><R><L><N><I><R><L><E><E><L><H><S><Q><P><T><F><F><P><G><G><L><R><F><S><V><C><L><F><R><R><I><V><A><C><H><F><I><K><P><R><T><L><L><D><Y><W><Q><A><L><E><N><S><R><G><E><D><C><P><P><V>
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.<BOP>
Q9Y2C3
P21730
C5AR1_HUMAN
C5a anaphylatoxin chemotactic receptor
Homo
<M><D><S><F><N><Y><T><T><P><D><Y><G><H><Y><D><D><K><D><T><L><D><L><N><T><P><V><D><K><T><S><N><T><L><R><V><P><D><I><L><A><L><V><I><F><A><V><V><F><L><V><G><V><L><G><N><A><L><V><V><W><V><T><A><F><E><A><K><R><T><I><N><A><I><W><F><L><N><L><A><V><A><D><F><L><S><C><L><A><L><P><I><L><F><T><S><I><V><Q><H><H><H><W><P><F><G><G><A><A><C><S><I><L><P><S><L><I><L><L><N><M><Y><A><S><I><L><L><L><A><T><I><S><A><D><R><F><L><L><V><F><K><P><I><W><C><Q><N><F><R><G><A><G><L><A><W><I><A><C><A><V><A><W><G><L><A><L><L><L><T><I><P><S><F><L><Y><R><V><V><R><E><E><Y><F><P><P><K><V><L><C><G><V><D><Y><S><H><D><K><R><R><E><R><A><V><A><I><V><R><L><V><L><G><F><L><W><P><L><L><T><L><T><I><C><Y><T><F><I><L><L><R><T><W><S><R><R><A><T><R><S><T><K><T><L><K><V><V><V><A><V><V><A><S><F><F><I><F><W><L><P><Y><Q><V><T><G><I><M><M><S><F><L><E><P><S><S><P><T><F><L><L><L><K><K><L><D><S><L><C><V><S><F><A><Y><I><N><C><C><I><N><P><I><I><Y><V><V><A><G><Q><G><F><Q><G><R><L><R><K><S><L><P><S><L><L><R><N><V><L><T><E><E><S><V><V><R><E><S><K><S><F><T><R><S><T><V><D><T><M><A><Q><K><T><Q><A><V>
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a . The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events . Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production .<BOP>
P21730
Q8IYL2
TRM44_HUMAN
Methyltransferase-like protein 19
Homo
<M><A><E><V><G><R><T><G><I><S><Y><P><G><A><L><L><P><Q><G><F><W><A><A><V><E><V><W><L><E><R><P><Q><V><A><N><K><R><L><C><G><A><R><L><E><A><R><W><S><A><A><L><P><C><A><E><A><R><G><P><G><T><S><A><G><S><E><Q><K><E><R><G><P><G><P><G><Q><G><S><P><G><G><G><P><G><P><R><S><L><S><G><P><E><Q><G><T><A><C><C><E><L><E><E><A><Q><G><Q><C><Q><Q><E><E><A><Q><R><E><A><A><S><V><P><L><R><D><S><G><H><P><G><H><A><E><G><R><E><G><D><F><P><A><A><D><L><D><S><L><W><E><D><F><S><Q><S><L><A><R><G><N><S><E><L><L><A><F><L><T><S><S><G><A><G><S><Q><P><E><A><Q><R><E><L><D><V><V><L><R><T><V><I><P><K><T><S><P><H><C><P><L><T><T><P><R><R><E><I><V><V><Q><D><V><L><N><G><T><I><T><F><L><P><L><E><E><D><D><E><G><N><L><K><V><K><M><S><N><V><Y><Q><I><Q><L><S><H><S><K><E><E><W><F><I><S><V><L><I><F><C><P><E><R><W><H><S><D><G><I><V><Y><P><K><P><T><W><L><G><E><E><L><L><A><K><L><A><K><W><S><V><E><N><K><K><S><D><F><K><S><T><L><S><L><I><S><I><M><K><Y><S><K><A><Y><Q><E><L><K><E><K><Y><K><E><M><V><K><V><W><P><E><V><T><D><P><E><K><F><V><Y><E><D><V><A><I><A><A><Y><L><L><I><L><W><E><E><E><R><A><E><R><R><L><T><A><R><Q><S><F><V><D><L><G><C><G><N><G><L><L><V><H><I><L><S><S><E><G><H><P><G><R><G><I><D><V><R><R><R><K><I><W><D><M><Y><G><P><Q><T><Q><L><E><E><D><A><I><T><P><N><D><K><T><L><F><P><D><V><D><W><L><I><G><N><H><S><D><E><L><T><P><W><I><P><V><I><A><A><R><S><S><Y><N><C><R><F><F><V><L><P><C><C><F><F><D><F><I><G><R><Y><S><R><R><Q><S><K><K><T><Q><Y><R><E><Y><L><D><F><I><K><E><V><G><F><T><C><G><F><H><V><D><E><D><C><L><R><I><P><S><T><K><R><V><C><L><V><G><K><S><R><T><Y><P><S><S><R><E><A><S><V><D><E><K><R><T><Q><Y><I><K><S><R><R><G><C><P><V><S><P><P><G><W><E><L><S><P><S><P><R><W><V><A><A><G><S><A><G><H><C><D><G><Q><Q><A><L><D><A><R><V><G><C><V><T><R><A><W><A><A><E><H><G><A><G><P><Q><A><E><G><P><W><L><P><G><F><H><P><R><E><K><A><E><R><V><R><N><C><A><A><L><P><R><D><F><I><D><Q><V><V><L><Q><V><A><N><L><L><L><G><G><K><Q><L><N><T><R><S><S><R><N><G><S><L><K><T><W><N><G><G><E><S><L><S><L><A><E><V><A><N><E><L><D><T><E><T><L><R><R><L><K><R><E><C><G><G><L><Q><T><L><L><R><N><S><H><Q><V><F><Q><V><V><N><G><R><V><H><I><R><D><W><R><E><E><T><L><W><K><T><K><Q><P><E><A><K><Q><R><L><L><S><E><A><C><K><T><R><L><C><W><F><F><M><H><H><P><D><G><C><A><L><S><T><D><C><C><P><F><A><H><G><P><A><E><L><R><P><P><R><T><T><P><R><K><K><I><S>
Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.<BOP>
Q8IYL2
Q8N8R3
MCATL_HUMAN
Solute carrier family 25 member 29
Homo
<M><A><L><D><F><L><A><G><C><A><G><G><V><A><G><V><L><V><G><H><P><F><D><T><V><K><V><R><L><Q><V><Q><S><V><E><K><P><Q><Y><R><G><T><L><H><C><F><K><S><I><I><K><Q><E><S><V><L><G><L><Y><K><G><L><G><S><P><L><M><G><L><T><F><I><N><A><L><V><F><G><V><Q><G><N><T><L><R><A><L><G><H><D><S><P><L><N><Q><F><L><A><G><A><A><A><G><A><I><Q><C><V><I><C><C><P><M><E><L><A><K><T><R><L><Q><L><Q><D><A><G><P><A><R><T><Y><K><G><S><L><D><C><L><A><Q><I><Y><G><H><E><G><L><R><G><V><N><R><G><M><V><S><T><L><L><R><E><T><P><S><F><G><V><Y><F><L><T><Y><D><A><L><T><R><A><L><G><C><E><P><G><D><R><L><L><V><P><K><L><L><L><A><G><G><T><S><G><I><V><S><W><L><S><T><Y><P><V><D><V><V><K><S><R><L><Q><A><D><G><L><R><G><A><P><R><Y><R><G><I><L><D><C><V><H><Q><S><Y><R><A><E><G><W><R><V><F><T><R><G><L><A><S><T><L><L><R><A><F><P><V><N><A><A><T><F><A><T><V><T><V><V><L><T><Y><A><R><G><E><E><A><G><P><E><G><E><A><V><P><A><A><P><A><G><P><A><L><A><Q><P><S><S><L>
Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine . Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 . Does not transport carnitine nor acylcarnitines . Functions by both counter-exchange and uniport mechanisms .<BOP>
Q8N8R3
Q92882
OSTF1_HUMAN
Osteoclast-stimulating factor 1
Homo
<M><S><K><P><P><P><K><P><V><K><P><G><Q><V><K><V><F><R><A><L><Y><T><F><E><P><R><T><P><D><E><L><Y><F><E><E><G><D><I><I><Y><I><T><D><M><S><D><T><N><W><W><K><G><T><S><K><G><R><T><G><L><I><P><S><N><Y><V><A><E><Q><A><E><S><I><D><N><P><L><H><E><A><A><K><R><G><N><L><S><W><L><R><E><C><L><D><N><R><V><G><V><N><G><L><D><K><A><G><S><T><A><L><Y><W><A><C><H><G><G><H><K><D><I><V><E><M><L><F><T><Q><P><N><I><E><L><N><Q><Q><N><K><L><G><D><T><A><L><H><A><A><A><W><K><G><Y><A><D><I><V><Q><L><L><L><A><K><G><A><R><T><D><L><R><N><I><E><K><K><L><A><F><D><M><A><T><N><A><A><C><A><S><L><L><K><K><K><Q><G><T><D><A><V><R><T><L><S><N><A><E><D><Y><L><D><D><E><D><S><D>
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.<BOP>
Q92882
Q8N4L4
SPEM1_HUMAN
Spermatid maturation protein 1
Homo
<M><A><M><V><E><R><P><R><P><E><W><A><S><Y><H><N><C><N><S><N><S><C><Q><D><L><G><N><S><V><L><L><L><L><G><L><I><I><C><I><N><I><S><I><N><I><V><T><L><L><W><S><R><F><R><G><V><L><Y><Q><V><F><H><D><T><I><C><E><K><E><A><P><K><S><S><L><L><R><K><Q><T><Q><P><P><K><K><Q><S><S><P><A><V><H><L><R><C><T><M><D><P><V><M><M><T><V><S><P><P><P><A><H><R><H><R><R><R><G><S><P><T><R><C><A><H><C><P><V><A><W><A><P><D><T><D><D><E><K><P><H><Q><Y><P><A><I><C><S><Y><H><W><D><V><P><E><D><W><E><G><F><Q><H><T><Q><G><T><W><V><P><W><S><Q><D><A><P><E><S><P><P><Q><T><I><R><F><Q><P><T><V><E><E><R><P><L><K><T><G><I><W><S><E><L><G><L><R><A><Y><V><Y><P><V><N><P><P><P><P><S><P><E><A><P><S><H><K><N><G><G><E><G><A><V><P><E><A><E><A><A><Q><Y><Q><P><V><P><A><P><T><L><G><P><A><V><I><P><E><F><S><R><H><R><S><S><G><R><I><V><Y><D><A><R><D><M><R><R><R><L><R><E><L><T><R><E><V><E><A><L><S><G><C><Y><P><L><A><S><G><S><S><T><A><E><E><T><S><K><N><W><V><Y><R><S><L><T><G><R>
Required for proper cytoplasm removal during spermatogenesis.<BOP>
Q8N4L4
Q9BXK5
B2L13_HUMAN
Protein Mil1
Homo
<M><A><S><S><S><T><V><P><L><G><F><H><Y><E><T><K><Y><V><V><L><S><Y><L><G><L><L><S><Q><E><K><L><Q><E><Q><H><L><S><S><P><Q><G><V><Q><L><D><I><A><S><Q><S><L><D><Q><E><I><L><L><K><V><K><T><E><I><E><E><E><L><K><S><L><D><K><E><I><S><E><A><F><T><S><T><G><F><D><R><H><T><S><P><V><F><S><P><A><N><P><E><S><S><M><E><D><C><L><A><H><L><G><E><K><V><S><Q><E><L><K><E><P><L><H><K><A><L><Q><M><L><L><S><Q><P><V><T><Y><Q><A><F><R><E><C><T><L><E><T><T><V><H><A><S><G><W><N><K><I><L><V><P><L><V><L><L><R><Q><M><L><L><E><L><T><R><R><G><Q><E><P><L><S><A><L><L><Q><F><G><V><T><Y><L><E><D><Y><S><A><E><Y><I><I><Q><Q><G><G><W><G><T><V><F><S><L><E><S><E><E><E><E><Y><P><G><I><T><A><E><D><S><N><D><I><Y><I><L><P><S><D><N><S><G><Q><V><S><P><P><E><S><P><T><V><T><T><S><W><Q><S><E><S><L><P><V><S><L><S><A><S><Q><S><W><H><T><E><S><L><P><V><S><L><G><P><E><S><W><Q><Q><I><A><M><D><P><E><E><V><K><S><L><D><S><N><G><A><G><E><K><S><E><N><N><S><S><N><S><D><I><V><H><V><E><K><E><E><V><P><E><G><M><E><E><A><A><V><A><S><V><V><L><P><A><R><E><L><Q><E><A><L><P><E><A><P><A><P><L><L><P><H><I><T><A><T><S><L><L><G><T><R><E><P><D><T><E><V><I><T><V><E><K><S><S><P><A><T><S><L><F><V><E><L><D><E><E><E><V><K><A><A><T><T><E><P><T><E><V><E><E><V><V><P><A><L><E><P><T><E><T><L><L><S><E><K><E><I><N><A><R><E><E><S><L><V><E><E><L><S><P><A><S><E><K><K><P><V><P><P><S><E><G><K><S><R><L><S><P><A><G><E><M><K><P><M><P><L><S><E><G><K><S><I><L><L><F><G><G><A><A><A><V><A><I><L><A><V><A><I><G><V><A><L><A><L><R><K><K>
May promote the activation of caspase-3 and apoptosis.<BOP>
Q9BXK5
P56278
MTCP1_HUMAN
Mature T-cell proliferation-1 type B1
Homo
<M><A><G><E><D><V><G><A><P><P><D><H><L><W><V><H><Q><E><G><I><Y><R><D><E><Y><Q><R><T><W><V><A><V><V><E><E><E><T><S><F><L><R><A><R><V><Q><Q><I><Q><V><P><L><G><D><A><A><R><P><S><H><L><L><T><S><Q><L><P><L><M><W><Q><L><Y><P><E><E><R><Y><M><D><N><N><S><R><L><W><Q><I><Q><H><H><L><M><V><R><G><V><Q><E><L><L><L><K><L><L><P><D><D>
Enhances the phosphorylation and activation of AKT1 and AKT2.<BOP>
P56278
Q96LW7
CAR19_HUMAN
Bcl10-interacting CARD protein
Homo
<M><T><D><Q><T><Y><C><D><R><L><V><Q><D><T><P><F><L><T><G><H><G><R><L><S><E><Q><Q><V><D><R><I><I><L><Q><L><N><R><Y><Y><P><Q><I><L><T><N><K><E><A><E><K><F><R><N><P><K><A><S><L><R><V><R><L><C><D><L><L><S><H><L><Q><R><S><G><E><R><D><C><Q><E><F><Y><R><A><L><Y><I><H><A><Q><P><L><H><S><R><L><P><S><R><H><A><L><R><K><F><H><I><T><N><H><A><C><L><V><L><A><R><G><G><H><P><S><L><P><L><M><A><W><M><S><S><M><T><T><Q><V><C><C><S><P><G><L><A><S><P><L><A><S><A><P><P><Q><R><P><P><S><G><P><E><G><R><V><W><Q><A><Q><A><V><Q><M><L><V><S><V><S><H><F><L><P><L><P><P><S><L><S><H><G><S><F><H><T><A><W><G><I><L><Y><V><H><S><C><P><S><F><S><N><L><I><P><R><G><S><L><H><V><C><V><D><S><N><L><V><P><T><A><A><W><R><S>
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.<BOP>
Q96LW7
P30711
GSTT1_HUMAN
Glutathione transferase T1-1
Homo
<M><G><L><E><L><Y><L><D><L><L><S><Q><P><C><R><A><V><Y><I><F><A><K><K><N><D><I><P><F><E><L><R><I><V><D><L><I><K><G><Q><H><L><S><D><A><F><A><Q><V><N><P><L><K><K><V><P><A><L><K><D><G><D><F><T><L><T><E><S><V><A><I><L><L><Y><L><T><R><K><Y><K><V><P><D><Y><W><Y><P><Q><D><L><Q><A><R><A><R><V><D><E><Y><L><A><W><Q><H><T><T><L><R><R><S><C><L><R><A><L><W><H><K><V><M><F><P><V><F><L><G><E><P><V><S><P><Q><T><L><A><A><T><L><A><E><L><D><V><T><L><Q><L><L><E><D><K><F><L><Q><N><K><A><F><L><T><G><P><H><I><S><L><A><D><L><V><A><I><T><E><L><M><H><P><V><G><A><G><C><Q><V><F><E><G><R><P><K><L><A><T><W><R><Q><R><V><E><A><A><V><G><E><D><L><F><Q><E><A><H><E><V><I><L><K><A><K><D><F><P><P><A><D><P><T><I><K><Q><K><L><M><P><W><V><L><A><M><I><R>
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.<BOP>
P30711
O00358
FOXE1_HUMAN
Thyroid transcription factor 2
Homo
<M><T><A><E><S><G><P><P><P><P><Q><P><E><V><L><A><T><V><K><E><E><R><G><E><T><A><A><G><A><G><V><P><G><E><A><T><G><R><G><A><G><G><R><R><R><K><R><P><L><Q><R><G><K><P><P><Y><S><Y><I><A><L><I><A><M><A><I><A><H><A><P><E><R><R><L><T><L><G><G><I><Y><K><F><I><T><E><R><F><P><F><Y><R><D><N><P><K><K><W><Q><N><S><I><R><H><N><L><T><L><N><D><C><F><L><K><I><P><R><E><A><G><R><P><G><K><G><N><Y><W><A><L><D><P><N><A><E><D><M><F><E><S><G><S><F><L><R><R><R><K><R><F><K><R><S><D><L><S><T><Y><P><A><Y><M><H><D><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><I><F><P><G><A><V><P><A><A><R><P><P><Y><P><G><A><V><Y><A><G><Y><A><P><P><S><L><A><A><P><P><P><V><Y><Y><P><A><A><S><P><G><P><C><R><V><F><G><L><V><P><E><R><P><L><S><P><E><L><G><P><A><P><S><G><P><G><G><S><C><A><F><A><S><A><G><A><P><A><T><T><T><G><Y><Q><P><A><G><C><T><G><A><R><P><A><N><P><S><A><Y><A><A><A><Y><A><G><P><D><G><A><Y><P><Q><G><A><G><S><A><I><F><A><A><A><G><R><L><A><G><P><A><S><P><P><A><G><G><S><S><G><G><V><E><T><T><V><D><F><Y><G><R><T><S><P><G><Q><F><G><A><L><G><A><C><Y><N><P><G><G><Q><L><G><G><A><S><A><G><A><Y><H><A><R><H><A><A><A><Y><P><G><G><I><D><R><F><V><S><A><M>
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.<BOP>
O00358
O60547
GMDS_HUMAN
GDP-D-mannose dehydratase
Homo
<M><A><H><A><P><A><R><C><P><S><A><R><G><S><G><D><G><E><M><G><K><P><R><N><V><A><L><I><T><G><I><T><G><Q><D><G><S><Y><L><A><E><F><L><L><E><K><G><Y><E><V><H><G><I><V><R><R><S><S><S><F><N><T><G><R><I><E><H><L><Y><K><N><P><Q><A><H><I><E><G><N><M><K><L><H><Y><G><D><L><T><D><S><T><C><L><V><K><I><I><N><E><V><K><P><T><E><I><Y><N><L><G><A><Q><S><H><V><K><I><S><F><D><L><A><E><Y><T><A><D><V><D><G><V><G><T><L><R><L><L><D><A><V><K><T><C><G><L><I><N><S><V><K><F><Y><Q><A><S><T><S><E><L><Y><G><K><V><Q><E><I><P><Q><K><E><T><T><P><F><Y><P><R><S><P><Y><G><A><A><K><L><Y><A><Y><W><I><V><V><N><F><R><E><A><Y><N><L><F><A><V><N><G><I><L><F><N><H><E><S><P><R><R><G><A><N><F><V><T><R><K><I><S><R><S><V><A><K><I><Y><L><G><Q><L><E><C><F><S><L><G><N><L><D><A><K><R><D><W><G><H><A><K><D><Y><V><E><A><M><W><L><M><L><Q><N><D><E><P><E><D><F><V><I><A><T><G><E><V><H><S><V><R><E><F><V><E><K><S><F><L><H><I><G><K><T><I><V><W><E><G><K><N><E><N><E><V><G><R><C><K><E><T><G><K><V><H><V><T><V><D><L><K><Y><Y><R><P><T><E><V><D><F><L><Q><G><D><C><T><K><A><K><Q><K><L><N><W><K><P><R><V><A><F><D><E><L><V><R><E><M><V><H><A><D><V><E><L><M><R><T><N><P><N><A>
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.<BOP>
O60547
Q99801
NKX31_HUMAN
Homeobox protein NK-3 homolog A
Homo
<M><L><R><V><P><E><P><R><P><G><E><A><K><A><E><G><A><A><P><P><T><P><S><K><P><L><T><S><F><L><I><Q><D><I><L><R><D><G><A><Q><R><Q><G><G><R><T><S><S><Q><R><Q><R><D><P><E><P><E><P><E><P><E><P><E><G><G><R><S><R><A><G><A><Q><N><D><Q><L><S><T><G><P><R><A><A><P><E><E><A><E><T><L><A><E><T><E><P><E><R><H><L><G><S><Y><L><L><D><S><E><N><T><S><G><A><L><P><R><L><P><Q><T><P><K><Q><P><Q><K><R><S><R><A><A><F><S><H><T><Q><V><I><E><L><E><R><K><F><S><H><Q><K><Y><L><S><A><P><E><R><A><H><L><A><K><N><L><K><L><T><E><T><Q><V><K><I><W><F><Q><N><R><R><Y><K><T><K><R><K><Q><L><S><S><E><L><G><D><L><E><K><H><S><S><L><P><A><L><K><E><E><A><F><S><R><A><S><L><V><S><V><Y><N><S><Y><P><Y><Y><P><Y><L><Y><C><V><G><S><W><S><P><A><F><W>
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.<BOP>
Q99801
P49721
PSB2_HUMAN
Proteasome component C7-I
Homo
<M><E><Y><L><I><G><I><Q><G><P><D><Y><V><L><V><A><S><D><R><V><A><A><S><N><I><V><Q><M><K><D><D><H><D><K><M><F><K><M><S><E><K><I><L><L><L><C><V><G><E><A><G><D><T><V><Q><F><A><E><Y><I><Q><K><N><V><Q><L><Y><K><M><R><N><G><Y><E><L><S><P><T><A><A><A><N><F><T><R><R><N><L><A><D><C><L><R><S><R><T><P><Y><H><V><N><L><L><L><A><G><Y><D><E><H><E><G><P><A><L><Y><Y><M><D><Y><L><A><A><L><A><K><A><P><F><A><A><H><G><Y><G><A><F><L><T><L><S><I><L><D><R><Y><Y><T><P><T><I><S><R><E><R><A><V><E><L><L><R><K><C><L><E><E><L><Q><K><R><F><I><L><N><L><P><T><F><S><V><R><I><I><D><K><N><G><I><H><D><L><D><N><I><S><F><P><K><Q><G><S>
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).<BOP>
P49721
Q9NRD0
FBX8_HUMAN
F-box/SEC7 protein FBS
Homo
<M><G><Q><G><L><W><R><V><V><R><N><Q><Q><L><Q><Q><E><G><Y><S><E><Q><G><Y><L><T><R><E><Q><S><R><R><M><A><A><S><N><I><S><N><T><N><H><R><K><Q><V><Q><G><G><I><D><I><Y><H><L><L><K><A><R><K><S><K><E><Q><E><G><F><I><N><L><E><M><L><P><P><E><L><S><F><T><I><L><S><Y><L><N><A><T><D><L><C><L><A><S><C><V><W><Q><D><L><A><N><D><E><L><L><W><Q><G><L><C><K><S><T><W><G><H><C><S><I><Y><N><K><N><P><P><L><G><F><S><F><R><K><L><Y><M><Q><L><D><E><G><S><L><T><F><N><A><N><P><D><E><G><V><N><Y><F><M><S><K><G><I><L><D><D><S><P><K><E><I><A><K><F><I><F><C><T><R><T><L><N><W><K><K><L><R><I><Y><L><D><E><R><R><D><V><L><D><D><L><V><T><L><H><N><F><R><N><Q><F><L><P><N><A><L><R><E><F><F><R><H><I><H><A><P><E><E><R><G><E><Y><L><E><T><L><I><T><K><F><S><H><R><F><C><A><C><N><P><D><L><M><R><E><L><G><L><S><P><D><A><V><Y><V><L><C><Y><S><L><I><L><L><S><I><D><L><T><S><P><H><V><K><N><K><M><S><K><R><E><F><I><R><N><T><R><R><A><A><Q><N><I><S><E><D><F><V><G><H><L><Y><D><N><I><Y><L><I><G><H><V><A><A>
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).<BOP>
Q9NRD0
Q96PH1
NOX5_HUMAN
NADPH oxidase 5
Homo
<M><N><T><S><G><D><P><A><Q><T><G><P><E><G><C><R><G><T><M><S><A><E><E><D><A><R><W><L><R><W><V><T><Q><Q><F><K><T><I><A><G><E><D><G><E><I><S><L><Q><E><F><K><A><A><L><H><V><K><E><S><F><F><A><E><R><F><F><A><L><F><D><S><D><R><S><G><T><I><T><L><Q><E><L><Q><E><A><L><T><L><L><I><H><G><S><P><M><D><K><L><K><F><L><F><Q><V><Y><D><I><D><V><C><A><R><Q><G><A><S><A><G><T><E><W><G><A><G><A><G><P><H><W><A><S><S><P><L><G><T><G><S><G><S><I><D><P><D><E><L><R><T><V><L><Q><S><C><L><R><E><S><A><I><S><L><P><D><E><K><L><D><Q><L><T><L><A><L><F><E><S><A><D><A><D><G><N><G><A><I><T><F><E><E><L><R><D><E><L><Q><R><F><P><G><V><M><E><N><L><T><I><S><A><A><H><W><L><T><A><P><A><P><R><P><R><P><R><R><P><R><Q><L><T><R><A><Y><W><H><N><H><R><S><Q><L><F><C><L><A><T><Y><A><G><L><H><V><L><L><F><G><L><A><A><S><A><H><R><D><L><G><A><S><V><M><V><A><K><G><C><G><Q><C><L><N><F><D><C><S><F><I><A><V><L><M><L><R><R><C><L><T><W><L><R><A><T><W><L><A><Q><V><L><P><L><D><Q><N><I><Q><F><H><Q><L><M><G><Y><V><V><V><G><L><S><L><V><H><T><V><A><H><T><V><N><F><V><L><Q><A><Q><A><E><A><S><P><F><Q><F><W><E><L><L><L><T><T><R><P><G><I><G><W><V><H><G><S><A><S><P><T><G><V><A><L><L><L><L><L><L><L><M><F><I><C><S><S><S><C><I><R><R><S><G><H><F><E><V><F><Y><W><T><H><L><S><Y><L><L><V><W><L><L><L><I><F><H><G><P><N><F><W><K><W><L><L><V><P><G><I><L><F><F><L><E><K><A><I><G><L><A><V><S><R><M><A><A><V><C><I><M><E><V><N><L><L><P><S><K><V><T><H><L><L><I><K><R><P><P><F><F><H><Y><R><P><G><D><Y><L><Y><L><N><I><P><T><I><A><R><Y><E><W><H><P><F><T><I><S><S><A><P><E><Q><K><D><T><I><W><L><H><I><R><S><Q><G><Q><W><T><N><R><L><Y><E><S><F><K><A><S><D><P><L><G><R><G><S><K><R><L><S><R><S><V><T><M><R><K><S><Q><R><S><S><K><G><S><E><I><L><L><E><K><H><K><F><C><N><I><K><C><Y><I><D><G><P><Y><G><T><P><T><R><R><I><F><A><S><E><H><A><V><L><I><G><A><G><I><G><I><T><P><F><A><S><I><L><Q><S><I><M><Y><R><H><Q><K><R><K><H><T><C><P><S><C><Q><H><S><W><I><E><G><V><Q><D><N><M><K><L><H><K><V><D><F><I><W><I><N><R><D><Q><R><S><F><E><W><F><V><S><L><L><T><K><L><E><M><D><Q><A><E><E><A><Q><Y><G><R><F><L><E><L><H><M><Y><M><T><S><A><L><G><K><N><D><M><K><A><I><G><L><Q><M><A><L><D><L><L><A><N><K><E><K><K><D><S><I><T><G><L><Q><T><R><T><Q><P><G><R><P><D><W><S><K><V><F><Q><K><V><A><A><E><K><K><G><K><V><Q><V><F><F><C><G><S><P><A><L><A><K><V><L><K><G><H><C><E><K><F><G><F><R><F><F><Q><E><N><F>
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.<BOP>
Q96PH1
Q9NQX6
ZN331_HUMAN
Zinc finger protein 463
Homo
<M><A><Q><G><L><V><T><F><A><D><V><A><I><D><F><S><Q><E><E><W><A><C><L><N><S><A><Q><R><D><L><Y><W><D><V><M><L><E><N><Y><S><N><L><V><S><L><D><L><E><S><A><Y><E><N><K><S><L><P><T><E><K><N><I><H><E><I><R><A><S><K><R><N><S><D><R><R><S><K><S><L><G><R><N><W><I><C><E><G><T><L><E><R><P><Q><R><S><R><G><R><Y><V><N><Q><M><I><I><N><Y><V><K><R><P><A><T><R><E><G><T><P><P><R><T><H><Q><R><H><H><K><E><N><S><F><E><C><K><D><C><G><K><A><F><S><R><G><Y><Q><L><S><Q><H><Q><K><I><H><T><G><E><K><P><Y><E><C><K><E><C><K><K><A><F><R><W><G><N><Q><L><T><Q><H><Q><K><I><H><T><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><R><W><G><S><S><L><V><I><H><K><R><I><H><T><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><R><R><G><D><E><L><T><Q><H><Q><R><F><H><T><G><E><K><D><Y><E><C><K><D><C><G><K><T><F><S><R><V><Y><K><L><I><Q><H><K><R><I><H><S><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><I><C><G><S><S><L><I><Q><H><K><R><I><H><T><G><E><K><P><Y><E><C><Q><E><C><G><K><A><F><T><R><V><N><Y><L><T><Q><H><Q><K><I><H><T><G><E><K><P><H><E><C><K><E><C><G><K><A><F><R><W><G><S><S><L><V><K><H><E><R><I><H><T><G><E><K><P><Y><K><C><T><E><C><G><K><A><F><N><C><G><Y><H><L><T><Q><H><E><R><I><H><T><G><E><T><P><Y><K><C><K><E><C><G><K><A><F><I><Y><G><S><S><L><V><K><H><E><R><I><H><T><G><V><K><P><Y><G><C><T><E><C><G><K><S><F><S><H><G><H><Q><L><T><Q><H><Q><K><T><H><S><G><A><K><S><Y><E><C><K><E><C><G><K><A><C><N><H><L><N><H><L><R><E><H><Q><R><I><H><N><S>
May be involved in transcriptional regulation. May play a role in spermatogenesis.<BOP>
Q9NQX6
O75940
SPF30_HUMAN
Survival motor neuron domain-containing protein 1
Homo
<M><S><E><D><L><A><K><Q><L><A><S><Y><K><A><Q><L><Q><Q><V><E><A><A><L><S><G><N><G><E><N><E><D><L><L><K><L><K><K><D><L><Q><E><V><I><E><L><T><K><D><L><L><S><T><Q><P><S><E><T><L><A><S><S><D><S><F><A><S><T><Q><P><T><H><S><W><K><V><G><D><K><C><M><A><V><W><S><E><D><G><Q><C><Y><E><A><E><I><E><E><I><D><E><E><N><G><T><A><A><I><T><F><A><G><Y><G><N><A><E><V><T><P><L><L><N><L><K><P><V><E><E><G><R><K><A><K><E><D><S><G><N><K><P><M><S><K><K><E><M><I><A><Q><Q><R><E><Y><K><K><K><K><A><L><K><K><A><Q><R><I><K><E><L><E><Q><E><R><E><D><Q><K><V><K><W><Q><Q><F><N><N><R><A><Y><S><K><N><K><K><G><Q><V><K><R><S><I><F><A><S><P><E><S><V><T><G><K><V><G><V><G><T><C><G><I><A><D><K><P><M><T><Q><Y><Q><D><T><S><K><Y><N><V><R><H><L><M><P><Q>
Involved in spliceosome assembly.<BOP>
O75940
Q8TF50
ZN526_HUMAN
Zinc finger protein 526
Homo
<M><A><E><V><V><A><E><V><A><E><M><P><T><Q><M><S><P><G><A><V><E><M><S><T><P><M><S><A><E><M><M><E><M><S><T><E><V><T><E><M><T><P><G><E><A><L><A><S><S><L><F><F><Q><H><H><Q><F><M><C><S><E><C><G><S><L><Y><N><T><L><E><E><V><L><S><H><Q><E><Q><H><M><L><A><V><S><E><E><E><A><L><T><T><Q><N><V><G><L><E><P><E><L><V><P><G><A><E><G><P><F><Q><C><G><E><C><S><Q><L><I><L><S><P><G><E><L><L><A><H><Q><D><A><H><L><R><E><S><A><N><Q><I><Q><Y><Q><C><W><D><C><Q><E><L><F><P><S><P><E><L><W><V><A><H><R><K><A><Q><H><L><S><A><T><V><A><E><P><P><V><P><P><P><L><P><P><P><T><P><L><P><P><P><S><P><P><S><E><V><K><M><E><P><Y><E><C><P><E><C><S><T><L><C><A><T><P><E><E><F><L><E><H><Q><G><T><H><F><D><S><L><E><K><E><E><R><N><G><L><E><E><E><E><E><D><D><E><E><D><E><E><D><D><E><E><M><E><D><E><E><A><M><A><E><V><G><D><D><A><V><G><G><D><E><S><T><A><G><W><A><Q><G><C><G><D><C><P><Q><H><Q><P><S><A><G><A><R><R><Q><H><R><R><T><A><H><S><P><A><S><A><T><H><P><F><H><C><S><Q><C><Q><R><S><F><S><S><A><N><R><L><Q><A><H><G><R><A><H><V><G><G><T><H><E><C><T><T><C><S><K><V><F><K><K><A><A><S><L><E><Q><H><L><R><L><H><R><G><E><A><R><Y><L><C><V><D><C><G><R><G><F><G><T><E><L><T><L><V><A><H><R><R><A><H><T><A><N><P><L><H><R><C><R><C><G><K><T><F><S><N><M><T><K><F><L><Y><H><R><R><T><H><A><G><K><S><G><A><P><P><T><G><A><T><A><P><P><A><P><A><E><P><T><P><P><P><P><P><P><A><P><P><A><Q><L><P><C><P><Q><C><S><K><S><F><A><S><A><S><R><L><S><R><H><R><R><A><V><H><G><P><P><E><R><R><H><R><C><G><V><C><G><K><G><F><K><K><L><I><H><V><R><N><H><L><R><T><H><T><G><E><R><P><F><Q><C><H><S><C><G><K><T><F><A><S><L><A><N><L><S><R><H><Q><L><T><H><T><G><A><R><P><Y><Q><C><L><D><C><G><K><R><F><T><Q><S><S><N><L><Q><Q><H><R><R><L><H><L><R><P><V><A><F><A><R><A><P><R><L><P><I><T><G><L><Y><N><K><S><P><Y><Y><C><G><T><C><G><R><W><F><R><A><M><A><G><L><R><L><H><Q><R><V><H><A><R><A><R><T><L><T><L><Q><P><P><R><S><P><S><P><A><P><P><P><P><P><E><P><Q><Q><T><I><M><C><T><E><L><G><E><T><I><A><I><I><E><T><S><Q><P><L><A><L><E><D><T><L><Q><L><C><Q><A><A><L><G><A><S><E><A><G><G><L><L><Q><L><D><T><A><F><V>
May be involved in transcriptional regulation.<BOP>
Q8TF50
Q9HB21
PKHA1_HUMAN
Tandem PH domain-containing protein 1
Homo
<M><P><Y><V><D><R><Q><N><R><I><C><G><F><L><D><I><E><E><N><E><N><S><G><K><F><L><R><R><Y><F><I><L><D><T><R><E><D><S><F><V><W><Y><M><D><N><P><Q><N><L><P><S><G><S><S><R><V><G><A><I><K><L><T><Y><I><S><K><V><S><D><A><T><K><L><R><P><K><A><E><F><C><F><V><M><N><A><G><M><R><K><Y><F><L><Q><A><N><D><Q><Q><D><L><V><E><W><V><N><V><L><N><K><A><I><K><I><T><V><P><K><Q><S><D><S><Q><P><N><S><D><N><L><S><R><H><G><E><C><G><K><K><Q><V><S><Y><R><T><D><I><V><G><G><V><P><I><I><T><P><T><Q><K><E><E><V><N><E><C><G><E><S><I><D><R><N><N><L><K><R><S><Q><S><H><L><P><Y><F><T><P><K><P><P><Q><D><S><A><V><I><K><A><G><Y><C><V><K><Q><G><A><V><M><K><N><W><K><R><R><Y><F><Q><L><D><E><N><T><I><G><Y><F><K><S><E><L><E><K><E><P><L><R><V><I><P><L><K><E><V><H><K><V><Q><E><C><K><Q><S><D><I><M><M><R><D><N><L><F><E><I><V><T><T><S><R><T><F><Y><V><Q><A><D><S><P><E><E><M><H><S><W><I><K><A><V><S><G><A><I><V><A><Q><R><G><P><G><R><S><A><S><S><E><H><P><P><G><P><S><E><S><K><H><A><F><R><P><T><N><A><A><T><A><T><S><H><S><T><A><S><R><S><N><S><L><V><S><T><F><T><M><E><K><R><G><F><Y><E><S><L><A><K><V><K><P><G><N><F><K><V><Q><T><V><S><P><R><E><P><A><S><K><V><T><E><Q><A><L><L><R><P><Q><S><K><N><G><P><Q><E><K><D><C><D><L><V><D><L><D><D><A><S><L><P><V><S><D><V>
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.<BOP>
Q9HB21
Q8TCD1
CR032_HUMAN
Putative NF-kappa-B-activating protein 200
Homo
<M><V><C><I><P><C><I><V><I><P><V><L><L><W><I><Y><K><K><F><L><E><P><Y><I><Y><P><L><V><S><P><F><V><S><R><I><W><P><K><K><A><I><Q><E><S><N><D><T><N><K><G><K><V><N><F><K><G><A><D><M><N><G><L><P><T><K><G><P><T><E><I><C><D><K><K><K><D>
May activate the NF-kappa-B signaling pathway.<BOP>
Q8TCD1
Q8TAX9
GSDMB_HUMAN
Gasdermin-B, C-terminal
Homo
<M><F><S><V><F><E><E><I><T><R><I><V><V><K><E><M><D><A><G><G><D><M><I><A><V><R><S><L><V><D><A><D><R><F><R><C><F><H><L><V><G><E><K><R><T><F><F><G><C><R><H><Y><T><T><G><L><T><L><M><D><I><L><D><T><D><G><D><K><W><L><D><E><L><D><S><G><L><Q><G><Q><K><A><E><F><Q><I><L><D><N><V><D><S><T><G><E><L><I><V><R><L><P><K><E><I><T><I><S><G><S><F><Q><G><F><H><H><Q><K><I><K><I><S><E><N><R><I><S><Q><Q><Y><L><A><T><L><E><N><R><K><L><K><R><E><L><P><F><S><F><R><S><I><N><T><R><E><N><L><Y><L><V><T><E><T><L><E><T><V><K><E><E><T><L><K><S><D><R><Q><Y><K><F><W><S><Q><I><S><Q><G><H><L><S><Y><K><H><K><G><Q><R><E><V><T><I><P><P><N><R><V><L><S><Y><R><V><K><Q><L><V><F><P><N><K><E><T><M><N><I><H><F><R><G><K><T><K><S><F><P><E><E><K><D><G><A><S><S><C><L><G><K><S><L><G><S><E><D><S><R><N><M><K><E><K><L><E><D><M><E><S><V><L><K><D><L><T><E><E><K><R><K><D><V><L><N><S><L><A><K><C><L><G><K><E><D><I><R><Q><D><L><E><Q><R><V><S><E><V><L><I><S><G><E><L><H><M><E><D><P><D><K><P><L><L><S><S><L><F><N><A><A><G><V><L><V><E><A><R><A><K><A><I><L><D><F><L><D><A><L><L><E><L><S><E><E><Q><Q><F><V><A><E><A><L><E><K><G><T><L><P><L><L><K><D><Q><V><K><S><V><M><E><Q><N><W><D><E><L><A><S><S><P><P><D><M><D><Y><D><P><E><A><R><I><L><C><A><L><Y><V><V><V><S><I><L><L><E><L><A><E><G><P><T><S><V><S><S>
Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells . Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form . After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid . Also binds sufatide, a component of the apical membrane of epithelial cells .<BOP>
Q8TAX9
P60323
NANO3_HUMAN
Nanos homolog 3
Homo
<M><G><T><F><D><L><W><T><D><Y><L><G><L><A><H><L><V><R><A><L><S><G><K><E><G><P><E><T><R><L><S><P><Q><P><E><P><E><P><M><L><E><P><D><Q><K><R><S><L><E><S><S><P><A><P><E><R><L><C><S><F><C><K><H><N><G><E><S><R><A><I><Y><Q><S><H><V><L><K><D><E><A><G><R><V><L><C><P><I><L><R><D><Y><V><C><P><Q><C><G><A><T><R><E><R><A><H><T><R><R><F><C><P><L><T><G><Q><G><Y><T><S><V><Y><S><H><T><T><R><N><S><A><G><K><K><L><V><R><P><D><K><A><K><T><Q><D><T><G><H><R><R><G><G><G><G><G><A><G><F><R><G><A><G><K><S><E><P><S><P><S><C><S><P><S><M><S><T>
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.<BOP>
P60323
P51801
CLCKB_HUMAN
ClC-K2
Homo
<M><E><E><F><V><G><L><R><E><G><S><S><G><N><P><V><T><L><Q><E><L><W><G><P><C><P><R><I><R><R><G><I><R><G><G><L><E><W><L><K><Q><K><L><F><R><L><G><E><D><W><Y><F><L><M><T><L><G><V><L><M><A><L><V><S><C><A><M><D><L><A><V><E><S><V><V><R><A><H><Q><W><L><Y><R><E><I><G><D><S><H><L><L><R><Y><L><S><W><T><V><Y><P><V><A><L><V><S><F><S><S><G><F><S><Q><S><I><T><P><S><S><G><G><S><G><I><P><E><V><K><T><M><L><A><G><V><V><L><E><D><Y><L><D><I><K><N><F><G><A><K><V><V><G><L><S><C><T><L><A><C><G><S><T><L><F><L><G><K><V><G><P><F><V><H><L><S><V><M><M><A><A><Y><L><G><R><V><R><T><T><T><I><G><E><P><E><N><K><S><K><Q><N><E><M><L><V><A><A><A><A><V><G><V><A><T><V><F><A><A><P><F><S><G><V><L><F><S><I><E><V><M><S><S><H><F><S><V><W><D><Y><W><R><G><F><F><A><A><T><C><G><A><F><M><F><R><L><L><A><V><F><N><S><E><Q><E><T><I><T><S><L><Y><K><T><S><F><R><V><D><V><P><F><D><L><P><E><I><F><F><F><V><A><L><G><G><L><C><G><I><L><G><S><A><Y><L><F><C><Q><R><I><F><F><G><F><I><R><N><N><R><F><S><S><K><L><L><A><T><S><K><P><V><Y><S><A><L><A><T><L><V><L><A><S><I><T><Y><P><P><S><A><G><R><F><L><A><S><R><L><S><M><K><Q><H><L><D><S><L><F><D><N><H><S><W><A><L><M><T><Q><N><S><S><P><P><W><P><E><E><L><D><P><Q><H><L><W><W><E><W><Y><H><P><R><F><T><I><F><G><T><L><A><F><F><L><V><M><K><F><W><M><L><I><L><A><T><T><I><P><M><P><A><G><Y><F><M><P><I><F><V><Y><G><A><A><I><G><R><L><F><G><E><T><L><S><F><I><F><P><E><G><I><V><A><G><G><I><T><N><P><I><M><P><G><G><Y><A><L><A><G><A><A><A><F><S><G><A><V><T><H><T><I><S><T><A><L><L><A><F><E><V><T><G><Q><I><V><H><A><L><P><V><L><M><A><V><L><A><A><N><A><I><A><Q><S><C><Q><P><S><F><Y><D><G><T><V><I><V><K><K><L><P><Y><L><P><R><I><L><G><R><N><I><G><S><H><R><V><R><V><E><H><F><M><N><H><S><I><T><T><L><A><K><D><M><P><L><E><E><V><V><K><V><V><T><S><T><D><V><A><K><Y><P><L><V><E><S><T><E><S><Q><I><L><V><G><I><V><R><R><A><Q><L><V><Q><A><L><K><A><E><P><P><S><W><A><P><G><H><Q><Q><C><L><Q><D><I><L><A><A><G><C><P><T><E><P><V><T><L><K><L><S><P><E><T><S><L><H><E><A><H><N><L><F><E><L><L><N><L><H><S><L><F><V><T><S><R><G><R><A><V><G><C><V><S><W><V><E><M><K><K><A><I><S><N><L><T><N><P><P><A><P><K>
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.<BOP>
P51801
O60563
CCNT1_HUMAN
Cyclin-T1
Homo
<M><E><G><E><R><K><N><N><N><K><R><W><Y><F><T><R><E><Q><L><E><N><S><P><S><R><R><F><G><V><D><P><D><K><E><L><S><Y><R><Q><Q><A><A><N><L><L><Q><D><M><G><Q><R><L><N><V><S><Q><L><T><I><N><T><A><I><V><Y><M><H><R><F><Y><M><I><Q><S><F><T><Q><F><P><G><N><S><V><A><P><A><A><L><F><L><A><A><K><V><E><E><Q><P><K><K><L><E><H><V><I><K><V><A><H><T><C><L><H><P><Q><E><S><L><P><D><T><R><S><E><A><Y><L><Q><Q><V><Q><D><L><V><I><L><E><S><I><I><L><Q><T><L><G><F><E><L><T><I><D><H><P><H><T><H><V><V><K><C><T><Q><L><V><R><A><S><K><D><L><A><Q><T><S><Y><F><M><A><T><N><S><L><H><L><T><T><F><S><L><Q><Y><T><P><P><V><V><A><C><V><C><I><H><L><A><C><K><W><S><N><W><E><I><P><V><S><T><D><G><K><H><W><W><E><Y><V><D><A><T><V><T><L><E><L><L><D><E><L><T><H><E><F><L><Q><I><L><E><K><T><P><N><R><L><K><R><I><W><N><W><R><A><C><E><A><A><K><K><T><K><A><D><D><R><G><T><D><E><K><T><S><E><Q><T><I><L><N><M><I><S><Q><S><S><S><D><T><T><I><A><G><L><M><S><M><S><T><S><T><T><S><A><V><P><S><L><P><V><S><E><E><S><S><S><N><L><T><S><V><E><M><L><P><G><K><R><W><L><S><S><Q><P><S><F><K><L><E><P><T><Q><G><H><R><T><S><E><N><L><A><L><T><G><V><D><H><S><L><P><Q><D><G><S><N><A><F><I><S><Q><K><Q><N><S><K><S><V><P><S><A><K><V><S><L><K><E><Y><R><A><K><H><A><E><E><L><A><A><Q><K><R><Q><L><E><N><M><E><A><N><V><K><S><Q><Y><A><Y><A><A><Q><N><L><L><S><H><H><D><S><H><S><S><V><I><L><K><M><P><I><E><G><S><E><N><P><E><R><P><F><L><E><K><A><D><K><T><A><L><K><M><R><I><P><V><A><G><G><D><K><A><A><S><S><K><P><E><E><I><K><M><R><I><K><V><H><A><A><A><D><K><H><N><S><V><E><D><S><V><T><K><S><R><E><H><K><E><K><H><K><T><H><P><S><N><H><H><H><H><H><N><H><H><S><H><K><H><S><H><S><Q><L><P><V><G><T><G><N><K><R><P><G><D><P><K><H><S><S><Q><T><S><N><L><A><H><K><T><Y><S><L><S><S><S><F><S><S><S><S><S><T><R><K><R><G><P><S><E><E><T><G><G><A><V><F><D><H><P><A><K><I><A><K><S><T><K><S><S><S><L><N><F><S><F><P><S><L><P><T><M><G><Q><M><P><G><H><S><S><D><T><S><G><L><S><F><S><Q><P><S><C><K><T><R><V><P><H><S><K><L><D><K><G><P><T><G><A><N><G><H><N><T><T><Q><T><I><D><Y><Q><D><T><V><N><M><L><H><S><L><L><S><A><Q><G><V><Q><P><T><Q><P><T><A><F><E><F><V><R><P><Y><S><D><Y><L><N><P><R><S><G><G><I><S><S><R><S><G><N><T><D><K><P><R><P><P><P><L><P><S><E><P><P><P><P><L><P><P><L><P><K>
(Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.<BOP>
O60563
P41217
OX2G_HUMAN
OX-2 membrane glycoprotein
Homo
<M><E><R><L><V><I><R><M><P><F><S><H><L><S><T><Y><S><L><V><W><V><M><A><A><V><V><L><C><T><A><Q><V><Q><V><V><T><Q><D><E><R><E><Q><L><Y><T><P><A><S><L><K><C><S><L><Q><N><A><Q><E><A><L><I><V><T><W><Q><K><K><K><A><V><S><P><E><N><M><V><T><F><S><E><N><H><G><V><V><I><Q><P><A><Y><K><D><K><I><N><I><T><Q><L><G><L><Q><N><S><T><I><T><F><W><N><I><T><L><E><D><E><G><C><Y><M><C><L><F><N><T><F><G><F><G><K><I><S><G><T><A><C><L><T><V><Y><V><Q><P><I><V><S><L><H><Y><K><F><S><E><D><H><L><N><I><T><C><S><A><T><A><R><P><A><P><M><V><F><W><K><V><P><R><S><G><I><E><N><S><T><V><T><L><S><H><P><N><G><T><T><S><V><T><S><I><L><H><I><K><D><P><K><N><Q><V><G><K><E><V><I><C><Q><V><L><H><L><G><T><V><T><D><F><K><Q><T><V><N><K><G><Y><W><F><S><V><P><L><L><L><S><I><V><S><L><V><I><L><L><V><L><I><S><I><L><L><Y><W><K><R><H><R><N><Q><D><R><G><E><L><S><Q><G><V><Q><K><M><T>
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.<BOP>
P41217
P11308
ERG_HUMAN
Transforming protein ERG
Homo
<M><A><S><T><I><K><E><A><L><S><V><V><S><E><D><Q><S><L><F><E><C><A><Y><G><T><P><H><L><A><K><T><E><M><T><A><S><S><S><S><D><Y><G><Q><T><S><K><M><S><P><R><V><P><Q><Q><D><W><L><S><Q><P><P><A><R><V><T><I><K><M><E><C><N><P><S><Q><V><N><G><S><R><N><S><P><D><E><C><S><V><A><K><G><G><K><M><V><G><S><P><D><T><V><G><M><N><Y><G><S><Y><M><E><E><K><H><M><P><P><P><N><M><T><T><N><E><R><R><V><I><V><P><A><D><P><T><L><W><S><T><D><H><V><R><Q><W><L><E><W><A><V><K><E><Y><G><L><P><D><V><N><I><L><L><F><Q><N><I><D><G><K><E><L><C><K><M><T><K><D><D><F><Q><R><L><T><P><S><Y><N><A><D><I><L><L><S><H><L><H><Y><L><R><E><T><P><L><P><H><L><T><S><D><D><V><D><K><A><L><Q><N><S><P><R><L><M><H><A><R><N><T><G><G><A><A><F><I><F><P><N><T><S><V><Y><P><E><A><T><Q><R><I><T><T><R><P><D><L><P><Y><E><P><P><R><R><S><A><W><T><G><H><G><H><P><T><P><Q><S><K><A><A><Q><P><S><P><S><T><V><P><K><T><E><D><Q><R><P><Q><L><D><P><Y><Q><I><L><G><P><T><S><S><R><L><A><N><P><G><S><G><Q><I><Q><L><W><Q><F><L><L><E><L><L><S><D><S><S><N><S><S><C><I><T><W><E><G><T><N><G><E><F><K><M><T><D><P><D><E><V><A><R><R><W><G><E><R><K><S><K><P><N><M><N><Y><D><K><L><S><R><A><L><R><Y><Y><Y><D><K><N><I><M><T><K><V><H><G><K><R><Y><A><Y><K><F><D><F><H><G><I><A><Q><A><L><Q><P><H><P><P><E><S><S><L><Y><K><Y><P><S><D><L><P><Y><M><G><S><Y><H><A><H><P><Q><K><M><N><F><V><A><P><H><P><P><A><L><P><V><T><S><S><S><F><F><A><A><P><N><P><Y><W><N><S><P><T><G><G><I><Y><P><N><T><R><L><P><T><S><H><M><P><S><H><L><G><T><Y><Y>
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.<BOP>
P11308
Q96G03
PGM2_HUMAN
Phosphoglucomutase-2
Homo
<M><A><A><P><E><G><S><G><L><G><E><D><A><R><L><D><Q><E><T><A><Q><W><L><R><W><D><K><N><S><L><T><L><E><A><V><K><R><L><I><A><E><G><N><K><E><E><L><R><K><C><F><G><A><R><M><E><F><G><T><A><G><L><R><A><A><M><G><P><G><I><S><R><M><N><D><L><T><I><I><Q><T><T><Q><G><F><C><R><Y><L><E><K><Q><F><S><D><L><K><Q><K><G><I><V><I><S><F><D><A><R><A><H><P><S><S><G><G><S><S><R><R><F><A><R><L><A><A><T><T><F><I><S><Q><G><I><P><V><Y><L><F><S><D><I><T><P><T><P><F><V><P><F><T><V><S><H><L><K><L><C><A><G><I><M><I><T><A><S><H><N><P><K><Q><D><N><G><Y><K><V><Y><W><D><N><G><A><Q><I><I><S><P><H><D><K><G><I><S><Q><A><I><E><E><N><L><E><P><W><P><Q><A><W><D><D><S><L><I><D><S><S><P><L><L><H><N><P><S><A><S><I><N><N><D><Y><F><E><D><L><K><K><Y><C><F><H><R><S><V><N><R><E><T><K><V><K><F><V><H><T><S><V><H><G><V><G><H><S><F><V><Q><S><A><F><K><A><F><D><L><V><P><P><E><A><V><P><E><Q><K><D><P><D><P><E><F><P><T><V><K><Y><P><N><P><E><E><G><K><G><V><L><T><L><S><F><A><L><A><D><K><T><K><A><R><I><V><L><A><N><D><P><D><A><D><R><L><A><V><A><E><K><Q><D><S><G><E><W><R><V><F><S><G><N><E><L><G><A><L><L><G><W><W><L><F><T><S><W><K><E><K><N><Q><D><R><S><A><L><K><D><T><Y><M><L><S><S><T><V><S><S><K><I><L><R><A><I><A><L><K><E><G><F><H><F><E><E><T><L><T><G><F><K><W><M><G><N><R><A><K><Q><L><I><D><Q><G><K><T><V><L><F><A><F><E><E><A><I><G><Y><M><C><C><P><F><V><L><D><K><D><G><V><S><A><A><V><I><S><A><E><L><A><S><F><L><A><T><K><N><L><S><L><S><Q><Q><L><K><A><I><Y><V><E><Y><G><Y><H><I><T><K><A><S><Y><F><I><C><H><D><Q><E><T><I><K><K><L><F><E><N><L><R><N><Y><D><G><K><N><N><Y><P><K><A><C><G><K><F><E><I><S><A><I><R><D><L><T><T><G><Y><D><D><S><Q><P><D><K><K><A><V><L><P><T><S><K><S><S><Q><M><I><T><F><T><F><A><N><G><G><V><A><T><M><R><T><S><G><T><E><P><K><I><K><Y><Y><A><E><L><C><A><P><P><G><N><S><D><P><E><Q><L><K><K><E><L><N><E><L><V><S><A><I><E><E><H><F><F><Q><P><Q><K><Y><N><L><Q><P><K><A><D>
Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. Catalyzes the interconversion of glucose-1-phosphate into glucose-6-phosphate but with a lower catalytic efficiency . In vitro, has also a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant .<BOP>
Q96G03
P14415
AT1B2_HUMAN
Sodium/potassium-dependent ATPase subunit beta-2
Homo
<M><V><I><Q><K><E><K><K><S><C><G><Q><V><V><E><E><W><K><E><F><V><W><N><P><R><T><H><Q><F><M><G><R><T><G><T><S><W><A><F><I><L><L><F><Y><L><V><F><Y><G><F><L><T><A><M><F><T><L><T><M><W><V><M><L><Q><T><V><S><D><H><T><P><K><Y><Q><D><R><L><A><T><P><G><L><M><I><R><P><K><T><E><N><L><D><V><I><V><N><V><S><D><T><E><S><W><D><Q><H><V><Q><K><L><N><K><F><L><E><P><Y><N><D><S><I><Q><A><Q><K><N><D><V><C><R><P><G><R><Y><Y><E><Q><P><D><N><G><V><L><N><Y><P><K><R><A><C><Q><F><N><R><T><Q><L><G><N><C><S><G><I><G><D><S><T><H><Y><G><Y><S><T><G><Q><P><C><V><F><I><K><M><N><R><V><I><N><F><Y><A><G><A><N><Q><S><M><N><V><T><C><A><G><K><R><D><E><D><A><E><N><L><G><N><F><V><M><F><P><A><N><G><N><I><D><L><M><Y><F><P><Y><Y><G><K><K><F><H><V><N><Y><T><Q><P><L><V><A><V><K><F><L><N><V><T><P><N><V><E><V><N><V><E><C><R><I><N><A><A><N><I><A><T><D><D><E><R><D><K><F><A><G><R><V><A><F><K><L><R><I><N><K><T>
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.<BOP>
P14415
P0C7T3
O56A5_HUMAN
Olfactory receptor 56A5
Homo
<M><T><L><P><S><N><N><S><T><S><P><V><F><E><F><F><L><I><C><F><P><S><F><Q><S><W><Q><H><W><L><S><L><P><L><S><L><L><F><L><L><A><M><G><A><N><A><T><L><L><I><T><I><Y><L><E><A><S><L><H><Q><P><L><Y><Y><L><L><S><L><L><S><L><L><D><I><V><L><C><L><T><V><I><P><K><V><L><A><I><F><W><F><D><L><R><S><I><S><F><P><A><C><F><L><Q><V><F><I><M><N><S><F><L><T><M><E><S><C><T><F><M><I><M><A><Y><D><R><Y><V><A><I><C><K><P><L><Q><Y><S><S><I><I><T><D><Q><F><V><A><R><A><A><I><F><V><V><A><R><N><G><L><L><T><M><P><I><P><I><L><S><S><R><L><R><Y><C><A><G><H><I><I><K><N><C><I><C><T><N><V><S><V><S><K><L><S><C><D><D><I><T><L><N><Q><S><Y><Q><F><V><I><G><W><T><L><L><G><S><D><L><I><L><I><V><L><S><Y><F><F><I><L><K><T><V><L><R><I><K><G><E><G><D><M><A><K><A><L><G><T><C><G><S><H><F><I><L><I><L><F><F><T><T><V><L><L><V><L><V><I><T><N><L><A><R><K><R><I><P><P><D><V><P><I><L><L><N><I><L><H><H><L><I><P><P><A><L><N><P><I><V><Y><G><V><R><T><K><E><I><K><Q><G><I><Q><N><L><L><R><R><L>
Odorant receptor.<BOP>
P0C7T3
Q969S6
TM203_HUMAN
Transmembrane protein 203
Homo
<M><L><F><S><L><R><E><L><V><Q><W><L><G><F><A><T><F><E><I><F><V><H><L><L><A><L><L><V><F><S><V><L><L><A><L><R><V><D><G><L><V><P><G><L><S><W><W><N><V><F><V><P><F><F><A><A><D><G><L><S><T><Y><F><T><T><I><V><S><V><R><L><F><Q><D><G><E><K><R><L><A><V><L><R><L><F><W><V><L><T><V><L><S><L><K><F><V><F><E><M><L><L><C><Q><K><L><A><E><Q><T><R><E><L><W><F><G><L><I><T><S><P><L><F><I><L><L><Q><L><L><M><I><R><A><C><R><V><N>
Involved in the regulation of cellular calcium homeotasis . Required for spermatogenesis .<BOP>
Q969S6
P51817
PRKX_HUMAN
Protein kinase PKX1
Homo
<M><E><A><P><G><L><A><Q><A><A><A><A><E><S><D><S><R><K><V><A><E><E><T><P><D><G><A><P><A><L><C><P><S><P><E><A><L><S><P><E><P><P><V><Y><S><L><Q><D><F><D><T><L><A><T><V><G><T><G><T><F><G><R><V><H><L><V><K><E><K><T><A><K><H><F><F><A><L><K><V><M><S><I><P><D><V><I><R><L><K><Q><E><Q><H><V><H><N><E><K><S><V><L><K><E><V><S><H><P><F><L><I><R><L><F><W><T><W><H><D><E><R><F><L><Y><M><L><M><E><Y><V><P><G><G><E><L><F><S><Y><L><R><N><R><G><R><F><S><S><T><T><G><L><F><Y><S><A><E><I><I><C><A><I><E><Y><L><H><S><K><E><I><V><Y><R><D><L><K><P><E><N><I><L><L><D><R><D><G><H><I><K><L><T><D><F><G><F><A><K><K><L><V><D><R><T><W><T><L><C><G><T><P><E><Y><L><A><P><E><V><I><Q><S><K><G><H><G><R><A><V><D><W><W><A><L><G><I><L><I><F><E><M><L><S><G><F><P><P><F><F><D><D><N><P><F><G><I><Y><Q><K><I><L><A><G><K><I><D><F><P><R><H><L><D><F><H><V><K><D><L><I><K><K><L><L><V><V><D><R><T><R><R><L><G><N><M><K><N><G><A><N><D><V><K><H><H><R><W><F><R><S><V><D><W><E><A><V><P><Q><R><K><L><K><P><P><I><V><P><K><I><A><G><D><G><D><T><S><N><F><E><T><Y><P><E><N><D><W><D><T><A><A><P><V><P><Q><K><D><L><E><I><F><K><N><F>
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation.<BOP>
P51817
Q9BYR3
KRA44_HUMAN
Ultrahigh sulfur keratin-associated protein 4.4
Homo
<M><V><N><S><C><C><G><S><V><C><S><D><Q><G><C><G><L><E><N><C><C><R><P><S><Y><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><T><T><C><C><R><T><T><C><C><H><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><Q><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><C><P><S><Y><C><V><S><S><C><C><R><P><Q><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><R><C><Y><R><P><H><C><G><Q><S><L><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BYR3
Q96K30
RITA1_HUMAN
RBPJ-interacting and tubulin-associated protein
Homo
<M><K><T><P><V><E><L><A><V><S><G><M><Q><T><L><G><L><Q><H><R><C><R><G><G><Y><R><V><K><A><R><T><S><Y><V><D><E><T><L><F><G><S><P><A><G><T><R><P><T><P><P><D><F><D><P><P><W><V><E><K><A><N><R><T><R><G><V><G><K><E><A><S><K><A><L><G><A><K><G><S><C><E><T><T><P><S><R><G><S><T><P><T><L><T><P><R><K><K><N><K><Y><R><P><I><S><H><T><P><S><Y><C><D><E><S><L><F><G><S><R><S><E><G><A><S><F><G><A><P><R><M><A><K><G><D><A><A><K><L><R><A><L><L><W><T><P><P><P><T><P><R><G><S><H><S><P><R><P><R><E><A><P><L><R><A><I><H><P><A><G><P><S><K><T><E><P><G><P><A><A><D><S><Q><K><L><S><M><G><G><L><H><S><S><R><P><L><K><R><G><L><S><H><S><L><T><H><L><N><V><P><S><T><G><H><P><A><T><S><A><P><H><T><N><G><P><Q><D><L><R><P><S><T><S><G><V><T><F><R><S><P><L><V><T><S><R><A><R><S><V><S><I><S><V><P><S><T><P><R><R><G><G><A><T><Q><K><P><K><P><P><W><K>
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.<BOP>
Q96K30
Q15910
EZH2_HUMAN
Lysine N-methyltransferase 6
Homo
<M><G><Q><T><G><K><K><S><E><K><G><P><V><C><W><R><K><R><V><K><S><E><Y><M><R><L><R><Q><L><K><R><F><R><R><A><D><E><V><K><S><M><F><S><S><N><R><Q><K><I><L><E><R><T><E><I><L><N><Q><E><W><K><Q><R><R><I><Q><P><V><H><I><L><T><S><V><S><S><L><R><G><T><R><E><C><S><V><T><S><D><L><D><F><P><T><Q><V><I><P><L><K><T><L><N><A><V><A><S><V><P><I><M><Y><S><W><S><P><L><Q><Q><N><F><M><V><E><D><E><T><V><L><H><N><I><P><Y><M><G><D><E><V><L><D><Q><D><G><T><F><I><E><E><L><I><K><N><Y><D><G><K><V><H><G><D><R><E><C><G><F><I><N><D><E><I><F><V><E><L><V><N><A><L><G><Q><Y><N><D><D><D><D><D><D><D><G><D><D><P><E><E><R><E><E><K><Q><K><D><L><E><D><H><R><D><D><K><E><S><R><P><P><R><K><F><P><S><D><K><I><F><E><A><I><S><S><M><F><P><D><K><G><T><A><E><E><L><K><E><K><Y><K><E><L><T><E><Q><Q><L><P><G><A><L><P><P><E><C><T><P><N><I><D><G><P><N><A><K><S><V><Q><R><E><Q><S><L><H><S><F><H><T><L><F><C><R><R><C><F><K><Y><D><C><F><L><H><P><F><H><A><T><P><N><T><Y><K><R><K><N><T><E><T><A><L><D><N><K><P><C><G><P><Q><C><Y><Q><H><L><E><G><A><K><E><F><A><A><A><L><T><A><E><R><I><K><T><P><P><K><R><P><G><G><R><R><R><G><R><L><P><N><N><S><S><R><P><S><T><P><T><I><N><V><L><E><S><K><D><T><D><S><D><R><E><A><G><T><E><T><G><G><E><N><N><D><K><E><E><E><E><K><K><D><E><T><S><S><S><S><E><A><N><S><R><C><Q><T><P><I><K><M><K><P><N><I><E><P><P><E><N><V><E><W><S><G><A><E><A><S><M><F><R><V><L><I><G><T><Y><Y><D><N><F><C><A><I><A><R><L><I><G><T><K><T><C><R><Q><V><Y><E><F><R><V><K><E><S><S><I><I><A><P><A><P><A><E><D><V><D><T><P><P><R><K><K><K><R><K><H><R><L><W><A><A><H><C><R><K><I><Q><L><K><K><D><G><S><S><N><H><V><Y><N><Y><Q><P><C><D><H><P><R><Q><P><C><D><S><S><C><P><C><V><I><A><Q><N><F><C><E><K><F><C><Q><C><S><S><E><C><Q><N><R><F><P><G><C><R><C><K><A><Q><C><N><T><K><Q><C><P><C><Y><L><A><V><R><E><C><D><P><D><L><C><L><T><C><G><A><A><D><H><W><D><S><K><N><V><S><C><K><N><C><S><I><Q><R><G><S><K><K><H><L><L><L><A><P><S><D><V><A><G><W><G><I><F><I><K><D><P><V><Q><K><N><E><F><I><S><E><Y><C><G><E><I><I><S><Q><D><E><A><D><R><R><G><K><V><Y><D><K><Y><M><C><S><F><L><F><N><L><N><N><D><F><V><V><D><A><T><R><K><G><N><K><I><R><F><A><N><H><S><V><N><P><N><C><Y><A><K><V><M><M><V><N><G><D><H><R><I><G><I><F><A><K><R><A><I><Q><T><G><E><E><L><F><F><D><Y><R><Y><S><Q><A><D><A><L><K><Y><V><G><I><E><R><E><M><E><I><P>
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 . Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes re
Q15910
Q6E0U4
DMKN_HUMAN
null
Homo
<M><K><F><Q><G><P><L><A><C><L><L><L><A><L><C><L><G><S><G><E><A><G><P><L><Q><S><G><E><E><S><T><G><T><N><I><G><E><A><L><G><H><G><L><G><D><A><L><S><E><G><V><G><K><A><I><G><K><E><A><G><G><A><A><G><S><K><V><S><E><A><L><G><Q><G><T><R><E><A><V><G><T><G><V><R><Q><V><P><G><F><G><V><A><D><A><L><G><N><R><V><G><E><A><A><H><A><L><G><N><T><G><H><E><I><G><R><Q><A><E><D><V><I><R><H><G><A><D><A><V><R><G><S><W><Q><G><V><P><G><H><N><G><A><W><E><T><S><G><G><H><G><I><F><G><S><Q><G><G><L><G><G><Q><G><Q><G><N><P><G><G><L><G><T><P><W><V><H><G><Y><P><G><N><S><A><G><S><F><G><M><N><P><Q><G><A><P><W><G><Q><G><G><N><G><G><P><P><N><F><G><T><N><T><Q><G><A><V><A><Q><P><G><Y><G><S><V><R><A><S><N><Q><N><E><G><C><T><N><P><P><P><S><G><S><G><G><G><S><S><N><S><G><G><G><S><G><S><Q><S><G><S><S><G><S><G><S><N><G><D><N><N><N><G><S><S><S><G><G><S><S><S><G><S><S><S><G><G><S><S><G><G><S><S><G><G><S><S><G><N><S><G><G><S><R><G><D><S><G><S><E><S><S><W><G><S><S><T><G><S><S><S><G><N><H><G><G><S><G><G><G><N><G><H><K><P><G><C><E><K><P><G><N><E><A><R><G><S><G><E><S><G><I><Q><N><S><E><T><S><P><G><M><F><N><F><D><T><F><W><K><N><F><K><S><K><L><G><F><I><N><W><D><A><I><N><K><N><Q><V><P><P><P><S><T><R><A><L><L><Y><F><S><R><L><W><E><D><F><K><Q><N><T><P><F><L><N><W><K><A><I><I><E><G><A><D><A><S><S><L><Q><K><R><A><G><R><D><D><Q><N><Y><N><Y><N><Q><H><A><Y><P><T><A><Y><G><G><K><Y><S><V><K><T><P><A><K><G><G><V><S><P><S><S><S><A><S><R><V><Q><P><G><L><L><Q><W><V><K><F><W>
May act as a soluble regulator of keratinocyte differentiation.<BOP>
Q6E0U4
Q5W5W9
RES18_HUMAN
Regulated endocrine-specific protein 18
Homo
<M><A><V><D><V><E><F><G><V><A><G><W><W><E><A><A><A><P><L><S><P><S><A><V><A><A><T><F><T><E><T><W><P><G><S><E><R><A><E><P><G><R><I><Q><H><P><L><W><P><G><S><S><E><G><L><Q><L><L><V><C><F><L><L><L><N><S><C><P><G><G><C><S><D><T><S><A><H><D><G><Q><D><Q><V><G><V><G><Q><L><W><P><L><Q><G><F><A><T><P><V><F><Q><H><L><Q><V><V><L><Q><Q><I><I><P><Q><G><L><F><W><K><D><D><I><T><Q><D><A><M><I><Q><K><M><E><H><A><S><R><L><H><P><Q><E><P><C><L><K><D><G><K><A><L><F><P><T><K><T><T><E><S><P><L><A><K><V><N><R><D><Q><C><F><T><S><E><V><V><S><K><A><L><K><Q><E><V><A><N><P><V><K><I><T><Y><R><C><S><Y><G><G><L><D><M><M><Q><A><P><G><P><S><K><E><E><I><I><Y><K><I><M><R><L><L><W><A><T><S><Y><C><G><P><Q><P><C><G>
May play an important regulatory role in corticotrophs.<BOP>
Q5W5W9
O14625
CXL11_HUMAN
Small-inducible cytokine B11
Homo
<M><S><V><K><G><M><A><I><A><L><A><V><I><L><C><A><T><V><V><Q><G><F><P><M><F><K><R><G><R><C><L><C><I><G><P><G><V><K><A><V><K><V><A><D><I><E><K><A><S><I><M><Y><P><S><N><N><C><D><K><I><E><V><I><I><T><L><K><E><N><K><G><Q><R><C><L><N><P><K><S><K><Q><A><R><L><I><I><K><K><V><E><R><K><N><F>
Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.<BOP>
O14625
P01303
NPY_HUMAN
C-flanking peptide of NPY
Homo
<M><L><G><N><K><R><L><G><L><S><G><L><T><L><A><L><S><L><L><V><C><L><G><A><L><A><E><A><Y><P><S><K><P><D><N><P><G><E><D><A><P><A><E><D><M><A><R><Y><Y><S><A><L><R><H><Y><I><N><L><I><T><R><Q><R><Y><G><K><R><S><S><P><E><T><L><I><S><D><L><L><M><R><E><S><T><E><N><V><P><R><T><R><L><E><D><P><A><M><W>
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.<BOP>
P01303
P24666
PPAC_HUMAN
Red cell acid phosphatase 1
Homo
<M><A><E><Q><A><T><K><S><V><L><F><V><C><L><G><N><I><C><R><S><P><I><A><E><A><V><F><R><K><L><V><T><D><Q><N><I><S><E><N><W><R><V><D><S><A><A><T><S><G><Y><E><I><G><N><P><P><D><Y><R><G><Q><S><C><M><K><R><H><G><I><P><M><S><H><V><A><R><Q><I><T><K><E><D><F><A><T><F><D><Y><I><L><C><M><D><E><S><N><L><R><D><L><N><R><K><S><N><Q><V><K><T><C><K><A><K><I><E><L><L><G><S><Y><D><P><Q><K><Q><L><I><I><E><D><P><Y><Y><G><N><D><S><D><F><E><T><V><Y><Q><Q><C><V><R><C><C><R><A><F><L><E><K><A><H>
Does not possess phosphatase activity.<BOP>
P24666
Q96P69
GPR78_HUMAN
G-protein coupled receptor 78
Homo
<M><G><P><G><E><A><L><L><A><G><L><L><V><M><V><L><A><V><A><L><L><S><N><A><L><V><L><L><C><C><A><Y><S><A><E><L><R><T><R><A><S><G><V><L><L><V><N><L><S><L><G><H><L><L><L><A><A><L><D><M><P><F><T><L><L><G><V><M><R><G><R><T><P><S><A><P><G><A><C><Q><V><I><G><F><L><D><T><F><L><A><S><N><A><A><L><S><V><A><A><L><S><A><D><Q><W><L><A><V><G><F><P><L><R><Y><A><G><R><L><R><P><R><Y><A><G><L><L><L><G><C><A><W><G><Q><S><L><A><F><S><G><A><A><L><G><C><S><W><L><G><Y><S><S><A><F><A><S><C><S><L><R><L><P><P><E><P><E><R><P><R><F><A><A><F><T><A><T><L><H><A><V><G><F><V><L><P><L><A><V><L><C><L><T><S><L><Q><V><H><R><V><A><R><R><H><C><Q><R><M><D><T><V><T><M><K><A><L><A><L><L><A><D><L><H><P><S><V><R><Q><R><C><L><I><Q><Q><K><R><R><R><H><R><A><T><R><K><I><G><I><A><I><A><T><F><L><I><C><F><A><P><Y><V><M><T><R><L><A><E><L><V><P><F><V><T><V><N><A><Q><W><G><I><L><S><K><C><L><T><Y><S><K><A><V><A><D><P><F><T><Y><S><L><L><R><R><P><F><R><Q><V><L><A><G><M><V><H><R><L><L><K><R><T><P><R><P><A><S><T><H><D><S><S><L><D><V><A><G><M><V><H><Q><L><L><K><R><T><P><R><P><A><S><T><H><N><G><S><V><D><T><E><N><D><S><C><L><Q><Q><T><H>
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.<BOP>
Q96P69
A1KXE4
F168B_HUMAN
p20
Homo
<M><N><P><V><Y><S><P><G><S><S><G><V><P><Y><A><N><A><K><G><I><G><Y><P><A><G><F><P><M><G><Y><A><A><A><A><P><A><Y><S><P><N><M><Y><P><G><A><N><P><T><F><Q><T><G><Y><T><P><G><T><P><Y><K><V><S><C><S><P><T><S><G><A><V><P><P><Y><S><S><S><P><N><P><Y><Q><T><A><V><Y><P><V><R><S><A><Y><P><Q><Q><S><P><Y><A><Q><Q><G><T><Y><Y><T><Q><P><L><Y><A><A><P><P><H><V><I><H><H><T><T><V><V><Q><P><N><G><M><P><A><T><V><Y><P><A><P><I><P><P><P><R><G><N><G><V><T><M><G><M><V><A><G><T><T><M><A><M><S><A><G><T><L><L><T><A><H><S><P><T><P><V><A><P><H><P><V><T><V><P><T><Y><R><A><P><G><T><P><T><Y><S><Y><V><P><P><Q><W>
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.<BOP>
A1KXE4
Q8NH70
O4A16_HUMAN
Olfactory receptor OR11-117
Homo
<M><R><P><S><S><N><V><T><E><F><V><L><L><G><L><T><Q><D><P><D><V><K><K><T><L><F><V><M><F><L><L><I><Y><I><V><T><M><V><G><N><L><L><I><W><V><T><T><I><G><S><P><S><L><G><S><L><M><Y><F><F><L><A><Y><L><S><L><M><D><A><I><Y><S><T><A><M><S><P><K><L><M><I><D><L><L><C><D><K><I><A><I><S><L><S><A><C><M><G><Q><L><F><I><E><H><L><L><G><G><A><E><V><F><L><L><V><V><M><A><Y><D><R><Y><V><A><I><S><K><P><L><H><Y><L><N><I><M><N><R><L><V><C><I><L><L><L><V><V><A><M><I><G><G><F><V><H><S><V><V><Q><I><V><F><L><Y><S><L><P><I><C><G><P><N><V><I><D><H><S><V><C><D><M><Y><P><L><L><E><L><L><C><L><D><T><Y><F><I><G><L><T><V><V><A><N><G><G><I><I><C><M><V><I><F><T><F><L><L><I><S><C><G><V><I><L><N><F><L><K><T><Y><S><Q><E><E><R><H><K><A><L><P><T><C><I><S><H><I><I><V><V><A><L><V><F><V><P><C><I><F><M><Y><V><R><P><V><S><N><F><P><F><D><K><L><M><T><V><F><Y><S><I><I><T><L><M><L><N><P><L><I><Y><S><L><R><Q><S><E><M><K><N><A><M><K><N><L><W><C><E><K><L><S><I><V><R><K><R><V><S><P><T><L><N><I><F><I><P><S><S><K><A><T><N><R><R>
Odorant receptor.<BOP>
Q8NH70
Q6ZV50
RFX8_HUMAN
Regulatory factor X 8
Homo
<M><A><E><G><V><P><A><S><P><S><S><G><E><G><S><R><G><P><H><S><G><V><I><Q><W><L><V><D><N><F><C><I><C><E><E><C><S><V><P><R><C><L><M><Y><E><I><Y><V><E><T><C><G><Q><N><T><E><N><Q><V><N><P><A><T><F><G><K><L><V><R><L><V><F><P><D><L><G><T><R><R><L><G><T><R><G><S><A><R><Y><H><Y><D><G><I><C><I><K><K><S><S><F><F><Y><A><Q><Y><C><Y><L><I><G><E><K><R><Y><H><S><G><D><A><I><A><F><E><K><S><T><N><Y><N><S><I><I><Q><Q><E><A><T><C><E><D><H><S><P><M><K><T><D><P><V><G><S><P><L><S><E><F><R><R><C><P><F><L><E><Q><E><Q><A><K><K><Y><S><C><N><M><M><A><F><L><A><D><E><Y><C><N><Y><C><R><D><I><L><R><N><V><E><D><L><L><T><S><F><W><K><S><L><Q><Q><D><T><V><M><L><M><S><L><P><D><V><C><Q><L><F><K><C><Y><D><V><Q><L><Y><K><G><I><E><D><V><L><L><H><D><F><L><E><D><V><S><I><Q><Y><L><K><S><V><Q><L><F><S><K><K><F><K><L><W><L><L><N><A><L><E><G><V><P><A><L><L><Q><I><S><K><L><K><E><V><T><L><F><V><K><R><L><R><R><K><T><Y><L><S><N><M><A><K><T><M><R><M><V><L><K><S><K><R><R><V><S><V><L><K><S><D><L><Q><A><I><I><N><Q><G><T><L><A><T><S><K><K><A><L><A><S><D><R><S><G><A><D><E><L><E><N><N><P><E><M><K><C><L><R><N><L><I><S><L><L><G><T><S><T><D><L><R><V><F><L><S><C><L><S><S><H><L><Q><A><F><V><F><Q><T><S><R><S><K><E><E><F><T><K><L><A><A><S><F><Q><L><R><W><N><L><L><L><T><A><V><S><K><A><M><T><L><C><H><R><D><S><F><G><S><W><H><L><F><H><L><L><L><L><E><Y><M><I><H><I><L><Q><S><C><L><E><E><E><E><E><E><E><D><M><G><T><V><K><E><M><L><P><D><D><P><T><L><G><Q><P><D><Q><A><L><F><H><S><L><N><S><S><L><S><Q><A><C><A><S><P><S><M><E><P><L><G><V><M><P><T><H><M><G><Q><G><R><Y><P><V><G><V><S><N><M><V><L><R><I><L><G><F><L><V><D><T><A><M><G><N><K><L><I><Q><V><L><L><E><D><E><T><T><E><S><A><V><K><L><S><L><P><M><G><Q><E><A><L><I><T><L><K><D><G><Q><Q><F><V><I><Q><I><S><D><V><P><Q><S><S><E><D><I><Y><F><R><E><N><N><A><N><V>
May be a transcription factor.<BOP>
Q6ZV50
O95336
6PGL_HUMAN
6-phosphogluconolactonase
Homo
<M><A><A><P><A><P><G><L><I><S><V><F><S><S><S><Q><E><L><G><A><A><L><A><Q><L><V><A><Q><R><A><A><C><C><L><A><G><A><R><A><R><F><A><L><G><L><S><G><G><S><L><V><S><M><L><A><R><E><L><P><A><A><V><A><P><A><G><P><A><S><L><A><R><W><T><L><G><F><C><D><E><R><L><V><P><F><D><H><A><E><S><T><Y><G><L><Y><R><T><H><L><L><S><R><L><P><I><P><E><S><Q><V><I><T><I><N><P><E><L><P><V><E><E><A><A><E><D><Y><A><K><K><L><R><Q><A><F><Q><G><D><S><I><P><V><F><D><L><L><I><L><G><V><G><P><D><G><H><T><C><S><L><F><P><D><H><P><L><L><Q><E><R><E><K><I><V><A><P><I><S><D><S><P><K><P><P><P><Q><R><V><T><L><T><L><P><V><L><N><A><A><R><T><V><I><F><V><A><T><G><E><G><K><A><A><V><L><K><R><I><L><E><D><Q><E><E><N><P><L><P><A><A><L><V><Q><P><H><T><G><K><L><C><W><F><L><D><E><A><A><A><R><L><L><T><V><P><F><E><K><H><S><T><L>
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.<BOP>
O95336
A0A0K0K1E9
TVB77_HUMAN
T cell receptor beta variable 7-7
Homo
<M><G><T><S><L><L><C><W><V><V><L><G><F><L><G><T><D><H><T><G><A><G><V><S><Q><S><P><R><Y><K><V><T><K><R><G><Q><D><V><T><L><R><C><D><P><I><S><S><H><A><T><L><Y><W><Y><Q><Q><A><L><G><Q><G><P><E><F><L><T><Y><F><N><Y><E><A><Q><P><D><K><S><G><L><P><S><D><R><F><S><A><E><R><P><E><G><S><I><S><T><L><T><I><Q><R><T><E><Q><R><D><S><A><M><Y><R><C><A><S><S><L>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0K0K1E9
Q8TCW9
PKR1_HUMAN
GPR73a
Homo
<M><E><T><T><M><G><F><M><D><D><N><A><T><N><T><S><T><S><F><L><S><V><L><N><P><H><G><A><H><A><T><S><F><P><F><N><F><S><Y><S><D><Y><D><M><P><L><D><E><D><E><D><V><T><N><S><R><T><F><F><A><A><K><I><V><I><G><M><A><L><V><G><I><M><L><V><C><G><I><G><N><F><I><F><I><A><A><L><V><R><Y><K><K><L><R><N><L><T><N><L><L><I><A><N><L><A><I><S><D><F><L><V><A><I><V><C><C><P><F><E><M><D><Y><Y><V><V><R><Q><L><S><W><E><H><G><H><V><L><C><T><S><V><N><Y><L><R><T><V><S><L><Y><V><S><T><N><A><L><L><A><I><A><I><D><R><Y><L><A><I><V><H><P><L><R><P><R><M><K><C><Q><T><A><T><G><L><I><A><L><V><W><T><V><S><I><L><I><A><I><P><S><A><Y><F><T><T><E><T><V><L><V><I><V><K><S><Q><E><K><I><F><C><G><Q><I><W><P><V><D><Q><Q><L><Y><Y><K><S><Y><F><L><F><I><F><G><I><E><F><V><G><P><V><V><T><M><T><L><C><Y><A><R><I><S><R><E><L><W><F><K><A><V><P><G><F><Q><T><E><Q><I><R><K><R><L><R><C><R><R><K><T><V><L><V><L><M><C><I><L><T><A><Y><V><L><C><W><A><P><F><Y><G><F><T><I><V><R><D><F><F><P><T><V><F><V><K><E><K><H><Y><L><T><A><F><Y><I><V><E><C><I><A><M><S><N><S><M><I><N><T><L><C><F><V><T><V><K><N><D><T><V><K><Y><F><K><K><I><M><L><L><H><W><K><A><S><Y><N><G><G><K><S><S><A><D><L><D><L><K><T><I><G><M><P><A><T><E><E><V><D><C><I><R><L><K>
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.<BOP>
Q8TCW9
Q8N7H5
PAF1_HUMAN
Pancreatic differentiation protein 2
Homo
<M><A><P><T><I><Q><T><Q><A><Q><R><E><D><G><H><R><P><N><S><H><R><T><L><P><E><R><S><G><V><V><C><R><V><K><Y><C><N><S><L><P><D><I><P><F><D><P><K><F><I><T><Y><P><F><D><Q><N><R><F><V><Q><Y><K><A><T><S><L><E><K><Q><H><K><H><D><L><L><T><E><P><D><L><G><V><T><I><D><L><I><N><P><D><T><Y><R><I><D><P><N><V><L><L><D><P><A><D><E><K><L><L><E><E><E><I><Q><A><P><T><S><S><K><R><S><Q><Q><H><A><K><V><V><P><W><M><R><K><T><E><Y><I><S><T><E><F><N><R><Y><G><I><S><N><E><K><P><E><V><K><I><G><V><S><V><K><Q><Q><F><T><E><E><E><I><Y><K><D><R><D><S><Q><I><T><A><I><E><K><T><F><E><D><A><Q><K><S><I><S><Q><H><Y><S><K><P><R><V><T><P><V><E><V><M><P><V><F><P><D><F><K><M><W><I><N><P><C><A><Q><V><I><F><D><S><D><P><A><P><K><D><T><S><G><A><A><A><L><E><M><M><S><Q><A><M><I><R><G><M><M><D><E><E><G><N><Q><F><V><A><Y><F><L><P><V><E><E><T><L><K><K><R><K><R><D><Q><E><E><E><M><D><Y><A><P><D><D><V><Y><D><Y><K><I><A><R><E><Y><N><W><N><V><K><N><K><A><S><K><G><Y><E><E><N><Y><F><F><I><F><R><E><G><D><G><V><Y><Y><N><E><L><E><T><R><V><R><L><S><K><R><R><A><K><A><G><V><Q><S><G><T><N><A><L><L><V><V><K><H><R><D><M><N><E><K><E><L><E><A><Q><E><A><R><K><A><Q><L><E><N><H><E><P><E><E><E><E><E><E><E><M><E><T><E><E><K><E><A><G><G><S><D><E><E><Q><E><K><G><S><S><S><E><K><E><G><S><E><D><E><H><S><G><S><E><S><E><R><E><E><G><D><R><D><E><A><S><D><K><S><G><S><G><E><D><E><S><S><E><D><E><A><R><A><A><R><D><K><E><E><I><F><G><S><D><A><D><S><E><D><D><A><D><S><D><D><E><D><R><G><Q><A><Q><G><G><S><D><N><D><S><D><S><G><S><N><G><G><G><Q><R><S><R><S><H><S><R><S><A><S><P><F><P><S><G><S><E><H><S><A><Q><E><D><G><S><E><A><A><A><S><D><S><S><E><A><D><S><D><S><D>
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H
Q8N7H5
Q7L5D6
GET4_HUMAN
Transmembrane domain recognition complex 35 kDa subunit
Homo
<M><A><A><A><A><A><M><A><E><Q><E><S><A><R><N><G><G><R><N><R><G><G><V><Q><R><V><E><G><K><L><R><A><S><V><E><K><G><D><Y><Y><E><A><H><Q><M><Y><R><T><L><F><F><R><Y><M><S><Q><S><K><H><T><E><A><R><E><L><M><Y><S><G><A><L><L><F><F><S><H><G><Q><Q><N><S><A><A><D><L><S><M><L><V><L><E><S><L><E><K><A><E><V><E><V><A><D><E><L><L><E><N><L><A><K><V><F><S><L><M><D><P><N><S><P><E><R><V><T><F><V><S><R><A><L><K><W><S><S><G><G><S><G><K><L><G><H><P><R><L><H><Q><L><L><A><L><T><L><W><K><E><Q><N><Y><C><E><S><R><Y><H><F><L><H><S><A><D><G><E><G><C><A><N><M><L><V><E><Y><S><T><S><R><G><F><R><S><E><V><D><M><F><V><A><Q><A><V><L><Q><F><L><C><L><K><N><K><S><S><A><S><V><V><F><T><T><Y><T><Q><K><H><P><S><I><E><D><G><P><P><F><V><E><P><L><L><N><F><I><W><F><L><L><L><A><V><D><G><G><K><L><T><V><F><T><V><L><C><E><Q><Y><Q><P><S><L><R><R><D><P><M><Y><N><E><Y><L><D><R><I><G><Q><L><F><F><G><V><P><P><K><Q><T><S><S><Y><G><G><L><L><G><N><L><L><T><S><L><M><G><S><S><E><Q><E><D><G><E><E><S><P><S><D><G><S><P><I><E><L><D>
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum . The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (
Q7L5D6
A0A0C4DH25
KVD20_HUMAN
Immunoglobulin kappa variable 3D-20
Homo
<M><E><T><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><G><E><I><V><L><T><Q><S><P><A><T><L><S><L><S><P><G><E><R><A><T><L><S><C><G><A><S><Q><S><V><S><S><S><Y><L><A><W><Y><Q><Q><K><P><G><L><A><P><R><L><L><I><Y><D><A><S><S><R><A><T><G><I><P><D><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><R><L><E><P><E><D><F><A><V><Y><Y><C><Q><Q><Y><G><S><S><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0C4DH25
Q96FC7
PHIPL_HUMAN
Phytanoyl-CoA hydroxylase-interacting protein-like
Homo
<M><E><V><P><R><L><D><H><A><L><N><S><P><T><S><P><C><E><E><V><I><K><N><L><S><L><E><A><I><Q><L><C><D><R><D><G><N><K><S><Q><D><S><G><I><A><E><M><E><E><L><P><V><P><H><N><I><K><I><S><N><I><T><C><D><S><F><K><I><S><W><E><M><D><S><K><S><K><D><R><I><T><H><Y><F><I><D><L><N><K><K><E><N><K><N><S><N><K><F><K><H><K><D><V><P><T><K><L><V><A><K><A><V><P><L><P><M><T><V><R><G><H><W><F><L><S><P><R><T><E><Y><T><V><A><V><Q><T><A><S><K><Q><V><D><G><D><Y><V><V><S><E><W><S><E><I><I><E><F><C><T><A><D><Y><S><K><V><H><L><T><Q><L><L><E><K><A><E><V><I><A><G><R><M><L><K><F><S><V><F><Y><R><N><Q><H><K><E><Y><F><D><Y><V><R><E><H><H><G><N><A><M><Q><P><S><V><K><D><N><S><G><S><H><G><S><P><I><S><G><K><L><E><G><I><F><F><S><C><S><T><E><F><N><T><G><K><P><P><Q><D><S><P><Y><G><R><Y><R><F><E><I><A><A><E><K><L><F><N><P><N><T><N><L><Y><F><G><D><F><Y><C><M><Y><T><A><Y><H><Y><V><I><L><V><I><A><P><V><G><S><P><G><D><E><F><C><K><Q><R><L><P><Q><L><N><S><K><D><N><K><F><L><T><C><T><E><E><D><G><V><L><V><Y><H><H><A><Q><D><V><I><L><E><V><I><Y><T><D><P><V><D><L><S><V><G><T><V><A><E><I><T><G><H><Q><L><M><S><L><S><T><A><N><A><K><K><D><P><S><C><K><T><C><N><I><S><V><G><R>
May play a role in the development of the central system.<BOP>
Q96FC7
P34998
CRFR1_HUMAN
Corticotropin-releasing hormone receptor 1
Homo
<M><G><G><H><P><Q><L><R><L><V><K><A><L><L><L><L><G><L><N><P><V><S><A><S><L><Q><D><Q><H><C><E><S><L><S><L><A><S><N><I><S><G><L><Q><C><N><A><S><V><D><L><I><G><T><C><W><P><R><S><P><A><G><Q><L><V><V><R><P><C><P><A><F><F><Y><G><V><R><Y><N><T><T><N><N><G><Y><R><E><C><L><A><N><G><S><W><A><A><R><V><N><Y><S><E><C><Q><E><I><L><N><E><E><K><K><S><K><V><H><Y><H><V><A><V><I><I><N><Y><L><G><H><C><I><S><L><V><A><L><L><V><A><F><V><L><F><L><R><L><R><P><G><C><T><H><W><G><D><Q><A><D><G><A><L><E><V><G><A><P><W><S><G><A><P><F><Q><V><R><R><S><I><R><C><L><R><N><I><I><H><W><N><L><I><S><A><F><I><L><R><N><A><T><W><F><V><V><Q><L><T><M><S><P><E><V><H><Q><S><N><V><G><W><C><R><L><V><T><A><A><Y><N><Y><F><H><V><T><N><F><F><W><M><F><G><E><G><C><Y><L><H><T><A><I><V><L><T><Y><S><T><D><R><L><R><K><W><M><F><I><C><I><G><W><G><V><P><F><P><I><I><V><A><W><A><I><G><K><L><Y><Y><D><N><E><K><C><W><F><G><K><R><P><G><V><Y><T><D><Y><I><Y><Q><G><P><M><I><L><V><L><L><I><N><F><I><F><L><F><N><I><V><R><I><L><M><T><K><L><R><A><S><T><T><S><E><T><I><Q><Y><R><K><A><V><K><A><T><L><V><L><L><P><L><L><G><I><T><Y><M><L><F><F><V><N><P><G><E><D><E><V><S><R><V><V><F><I><Y><F><N><S><F><L><E><S><F><Q><G><F><F><V><S><V><F><Y><C><F><L><N><S><E><V><R><S><A><I><R><K><R><W><H><R><W><Q><D><K><H><S><I><R><A><R><V><A><R><A><M><S><I><P><T><S><P><T><R><V><S><F><H><S><I><K><Q><S><T><A><V>
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.<BOP>
P34998
P53634
CATC_HUMAN
Dipeptidyl peptidase I light chain
Homo
<M><G><A><G><P><S><L><L><L><A><A><L><L><L><L><L><S><G><D><G><A><V><R><C><D><T><P><A><N><C><T><Y><L><D><L><L><G><T><W><V><F><Q><V><G><S><S><G><S><Q><R><D><V><N><C><S><V><M><G><P><Q><E><K><K><V><V><V><Y><L><Q><K><L><D><T><A><Y><D><D><L><G><N><S><G><H><F><T><I><I><Y><N><Q><G><F><E><I><V><L><N><D><Y><K><W><F><A><F><F><K><Y><K><E><E><G><S><K><V><T><T><Y><C><N><E><T><M><T><G><W><V><H><D><V><L><G><R><N><W><A><C><F><T><G><K><K><V><G><T><A><S><E><N><V><Y><V><N><I><A><H><L><K><N><S><Q><E><K><Y><S><N><R><L><Y><K><Y><D><H><N><F><V><K><A><I><N><A><I><Q><K><S><W><T><A><T><T><Y><M><E><Y><E><T><L><T><L><G><D><M><I><R><R><S><G><G><H><S><R><K><I><P><R><P><K><P><A><P><L><T><A><E><I><Q><Q><K><I><L><H><L><P><T><S><W><D><W><R><N><V><H><G><I><N><F><V><S><P><V><R><N><Q><A><S><C><G><S><C><Y><S><F><A><S><M><G><M><L><E><A><R><I><R><I><L><T><N><N><S><Q><T><P><I><L><S><P><Q><E><V><V><S><C><S><Q><Y><A><Q><G><C><E><G><G><F><P><Y><L><I><A><G><K><Y><A><Q><D><F><G><L><V><E><E><A><C><F><P><Y><T><G><T><D><S><P><C><K><M><K><E><D><C><F><R><Y><Y><S><S><E><Y><H><Y><V><G><G><F><Y><G><G><C><N><E><A><L><M><K><L><E><L><V><H><H><G><P><M><A><V><A><F><E><V><Y><D><D><F><L><H><Y><K><K><G><I><Y><H><H><T><G><L><R><D><P><F><N><P><F><E><L><T><N><H><A><V><L><L><V><G><Y><G><T><D><S><A><S><G><M><D><Y><W><I><V><K><N><S><W><G><T><G><W><G><E><N><G><Y><F><R><I><R><R><G><T><D><E><C><A><I><E><S><I><A><V><A><A><T><P><I><P><K><L>
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.<BOP>
P53634
Q8IVC4
ZN584_HUMAN
Zinc finger protein 584
Homo
<M><A><G><E><A><E><A><Q><L><D><P><S><L><Q><G><L><V><M><F><E><D><V><T><V><Y><F><S><R><E><E><W><G><L><L><N><V><T><Q><K><G><L><Y><R><D><V><M><L><E><N><F><A><L><V><S><S><L><G><L><A><P><S><R><S><P><V><F><T><Q><L><E><D><D><E><Q><S><W><V><P><S><W><V><D><V><T><P><V><S><R><A><E><A><R><R><G><F><G><L><D><G><L><C><R><V><E><D><E><R><A><H><P><E><H><L><K><S><Y><R><V><I><Q><H><Q><D><T><H><S><E><G><K><P><R><R><H><T><E><H><G><A><A><F><P><P><G><S><S><C><G><Q><Q><Q><E><V><H><V><A><E><K><L><F><K><C><S><D><C><G><K><V><F><L><K><A><F><A><L><L><D><H><L><I><T><H><S><E><E><R><P><F><R><C><P><T><G><R><S><A><F><K><K><S><A><H><I><N><P><R><K><I><H><T><G><E><T><A><H><V><C><N><E><C><G><K><A><F><S><Y><P><S><K><L><R><K><H><Q><K><V><H><T><G><I><K><P><F><K><C><S><D><C><G><K><T><F><N><R><K><D><A><L><V><L><H><Q><R><I><H><T><G><E><R><P><Y><E><C><S><K><C><G><K><T><F><S><V><L><S><T><L><I><R><H><R><K><V><H><I><G><E><R><P><Y><E><C><T><E><C><G><K><F><F><K><Y><N><N><S><F><I><L><H><Q><R><V><H><T><G><E><R><P><F><E><C><K><Q><C><G><K><G><Y><V><T><R><S><G><L><Y><Q><H><W><K><V><H><T><G><E><R><P><Y><E><C><S><L><C><G><K><T><F><T><T><R><S><Y><R><N><R><H><Q><Q><F><H><T><E><E><R><S><Y><E><C><T><E><C><G><K><A><F><K><H><S><S><T><L><L><Q><H><K><K><V><H><T><P><E><R><R><Q><E><D><R><A><H><G><K><V><V><S><C>
May be involved in transcriptional regulation.<BOP>
Q8IVC4
Q9UK17
KCND3_HUMAN
Voltage-gated potassium channel subunit Kv4.3
Homo
<M><A><A><G><V><A><A><W><L><P><F><A><R><A><A><A><I><G><W><M><P><V><A><N><C><P><M><P><L><A><P><A><D><K><N><K><R><Q><D><E><L><I><V><L><N><V><S><G><R><R><F><Q><T><W><R><T><T><L><E><R><Y><P><D><T><L><L><G><S><T><E><K><E><F><F><F><N><E><D><T><K><E><Y><F><F><D><R><D><P><E><V><F><R><C><V><L><N><F><Y><R><T><G><K><L><H><Y><P><R><Y><E><C><I><S><A><Y><D><D><E><L><A><F><Y><G><I><L><P><E><I><I><G><D><C><C><Y><E><E><Y><K><D><R><K><R><E><N><A><E><R><L><M><D><D><N><D><S><E><N><N><Q><E><S><M><P><S><L><S><F><R><Q><T><M><W><R><A><F><E><N><P><H><T><S><T><L><A><L><V><F><Y><Y><V><T><G><F><F><I><A><V><S><V><I><T><N><V><V><E><T><V><P><C><G><T><V><P><G><S><K><E><L><P><C><G><E><R><Y><S><V><A><F><F><C><L><D><T><A><C><V><M><I><F><T><V><E><Y><L><L><R><L><F><A><A><P><S><R><Y><R><F><I><R><S><V><M><S><I><I><D><V><V><A><I><M><P><Y><Y><I><G><L><V><M><T><N><N><E><D><V><S><G><A><F><V><T><L><R><V><F><R><V><F><R><I><F><K><F><S><R><H><S><Q><G><L><R><I><L><G><Y><T><L><K><S><C><A><S><E><L><G><F><L><L><F><S><L><T><M><A><I><I><I><F><A><T><V><M><F><Y><A><E><K><G><S><S><A><S><K><F><T><S><I><P><A><S><F><W><Y><T><I><V><T><M><T><T><L><G><Y><G><D><M><V><P><K><T><I><A><G><K><I><F><G><S><I><C><S><L><S><G><V><L><V><I><A><L><P><V><P><V><I><V><S><N><F><S><R><I><Y><H><Q><N><Q><R><A><D><K><R><R><A><Q><K><K><A><R><L><A><R><I><R><V><A><K><T><G><S><S><N><A><Y><L><H><S><K><R><N><G><L><L><N><E><A><L><E><L><T><G><T><P><E><E><E><H><M><G><K><T><T><S><L><I><E><S><Q><H><H><H><L><L><H><C><L><E><K><T><T><G><L><S><Y><L><V><D><D><P><L><L><S><V><R><T><S><T><I><K><N><H><E><F><I><D><E><Q><M><F><E><Q><N><C><M><E><S><S><M><Q><N><Y><P><S><T><R><S><P><S><L><S><S><H><P><G><L><T><T><T><C><C><S><R><R><S><K><K><T><T><H><L><P><N><S><N><L><P><A><T><R><L><R><S><M><Q><E><L><S><T><I><H><I><Q><G><S><E><Q><P><S><L><T><T><S><R><S><S><L><N><L><K><A><D><D><G><L><R><P><N><C><K><T><S><Q><I><T><T><A><I><I><S><I><P><T><P><P><A><L><T><P><E><G><E><S><R><P><P><P><A><S><P><G><P><N><T><N><I><P><S><I><A><S><N><V><V><K><V><S><A><L>
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<BOP>
Q9UK17
Q9Y3X0
CCDC9_HUMAN
Coiled-coil domain-containing protein 9
Homo
<M><A><A><T><L><D><L><K><S><K><E><E><K><D><A><E><L><D><K><R><I><E><A><L><R><R><K><N><E><A><L><I><R><R><Y><Q><E><I><E><E><D><R><K><K><A><E><L><E><G><V><A><V><T><A><P><R><K><G><R><S><V><E><K><E><N><V><A><V><E><S><E><K><N><L><G><P><S><R><R><S><P><G><T><P><R><P><P><G><A><S><K><G><G><R><T><P><P><Q><Q><G><G><R><A><G><M><G><R><A><S><R><S><W><E><G><S><P><G><E><Q><P><R><G><G><G><A><G><G><R><G><R><R><G><R><G><R><G><S><P><H><L><S><G><A><G><D><T><S><I><S><D><R><K><S><K><E><W><E><E><R><R><R><Q><N><I><E><K><M><N><E><E><M><E><K><I><A><E><Y><E><R><N><Q><R><E><G><V><L><E><P><N><P><V><R><N><F><L><D><D><P><R><R><R><S><G><P><L><E><E><S><E><R><D><R><R><E><E><S><R><R><H><G><R><N><W><G><G><P><D><F><E><R><V><R><C><G><L><E><H><E><R><Q><G><R><R><A><G><L><G><S><A><G><D><M><T><L><S><M><T><G><R><E><R><S><E><Y><L><R><W><K><Q><E><R><E><K><I><D><Q><E><R><L><Q><R><H><R><K><P><T><G><Q><W><R><R><E><W><D><A><E><K><T><D><G><M><F><K><D><G><P><V><P><A><H><E><P><S><H><R><Y><D><D><Q><A><W><A><R><P><P><K><P><P><T><F><G><E><F><L><S><Q><H><K><A><E><A><S><S><R><R><R><R><K><S><S><R><P><Q><A><K><A><A><P><R><A><Y><S><D><H><D><D><R><W><E><T><K><E><G><A><A><S><P><A><P><E><T><P><Q><P><T><S><P><E><T><S><P><K><E><T><P><M><Q><P><P><E><I><P><A><P><A><H><R><P><P><E><D><E><G><E><E><N><E><G><E><E><D><E><E><W><E><D><I><S><E><D><E><E><E><E><E><I><E><V><E><E><G><D><E><E><E><P><A><Q><D><H><Q><A><P><E><A><A><P><T><G><I><P><C><S><E><Q><A><H><G><V><P><F><S><P><E><E><P><L><L><E><P><Q><A><P><G><T><P><S><S><P><F><S><P><P><S><G><H><Q><P><V><S><D><W><G><E><E><V><E><L><N><S><P><R><T><T><H><L><A><G><A><L><S><P><G><E><A><W><P><F><E><S><V>
Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation.<BOP>
Q9Y3X0
P56470
LEG4_HUMAN
Lactose-binding lectin 4
Homo
<M><A><Y><V><P><A><P><G><Y><Q><P><T><Y><N><P><T><L><P><Y><Y><Q><P><I><P><G><G><L><N><V><G><M><S><V><Y><I><Q><G><V><A><S><E><H><M><K><R><F><F><V><N><F><V><V><G><Q><D><P><G><S><D><V><A><F><H><F><N><P><R><F><D><G><W><D><K><V><V><F><N><T><L><Q><G><G><K><W><G><S><E><E><R><K><R><S><M><P><F><K><K><G><A><A><F><E><L><V><F><I><V><L><A><E><H><Y><K><V><V><V><N><G><N><P><F><Y><E><Y><G><H><R><L><P><L><Q><M><V><T><H><L><Q><V><D><G><D><L><Q><L><Q><S><I><N><F><I><G><G><Q><P><L><R><P><Q><G><P><P><M><M><P><P><Y><P><G><P><G><H><C><H><Q><Q><L><N><S><L><P><T><M><E><G><P><P><T><F><N><P><P><V><P><Y><F><G><R><L><Q><G><G><L><T><A><R><R><T><I><I><I><K><G><Y><V><P><P><T><G><K><S><F><A><I><N><F><K><V><G><S><S><G><D><I><A><L><H><I><N><P><R><M><G><N><G><T><V><V><R><N><S><L><L><N><G><S><W><G><S><E><E><K><K><I><T><H><N><P><F><G><P><G><Q><F><F><D><L><S><I><R><C><G><L><D><R><F><K><V><Y><A><N><G><Q><H><L><F><D><F><A><H><R><L><S><A><F><Q><R><V><D><T><L><E><I><Q><G><D><V><T><L><S><Y><V><Q><I>
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.<BOP>
P56470
Q8NGL2
OR5L1_HUMAN
Olfactory receptor OR11-151
Homo
<M><G><K><E><N><C><T><T><V><A><E><F><I><L><L><G><L><S><D><V><P><E><L><R><V><C><L><F><L><L><F><L><L><I><Y><G><V><T><L><L><A><N><L><G><M><I><A><L><I><Q><V><S><S><R><L><H><T><P><M><Y><F><F><L><S><H><L><S><S><V><D><F><C><Y><S><S><I><I><V><P><K><M><L><A><N><I><F><N><K><D><K><A><I><S><F><L><G><C><M><V><Q><F><Y><L><F><C><T><C><V><V><T><E><V><F><L><L><A><V><M><A><Y><D><R><F><V><A><I><C><N><P><L><L><Y><T><V><T><M><S><W><K><V><R><V><E><L><A><S><C><C><Y><F><C><G><T><V><C><S><L><I><H><L><C><L><A><L><R><I><P><F><Y><R><S><N><V><I><N><H><F><F><C><D><L><P><P><V><L><S><L><A><C><S><D><I><T><V><N><E><T><L><L><F><L><V><A><T><L><N><E><S><V><T><I><M><I><I><L><T><S><Y><L><L><I><L><T><T><I><L><K><M><G><S><A><E><G><R><H><K><A><F><S><T><C><A><S><H><L><T><A><I><T><V><F><H><G><T><V><L><S><I><Y><C><R><P><S><S><G><N><S><G><D><A><D><K><V><A><T><V><F><Y><T><V><V><I><P><M><L><N><S><V><I><Y><S><L><R><N><K><D><V><K><E><A><L><R><K><V><M><G><S><K><I><H><S>
Odorant receptor.<BOP>
Q8NGL2
P13010
XRCC5_HUMAN
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Homo
<M><V><R><S><G><N><K><A><A><V><V><L><C><M><D><V><G><F><T><M><S><N><S><I><P><G><I><E><S><P><F><E><Q><A><K><K><V><I><T><M><F><V><Q><R><Q><V><F><A><E><N><K><D><E><I><A><L><V><L><F><G><T><D><G><T><D><N><P><L><S><G><G><D><Q><Y><Q><N><I><T><V><H><R><H><L><M><L><P><D><F><D><L><L><E><D><I><E><S><K><I><Q><P><G><S><Q><Q><A><D><F><L><D><A><L><I><V><S><M><D><V><I><Q><H><E><T><I><G><K><K><F><E><K><R><H><I><E><I><F><T><D><L><S><S><R><F><S><K><S><Q><L><D><I><I><I><H><S><L><K><K><C><D><I><S><L><Q><F><F><L><P><F><S><L><G><K><E><D><G><S><G><D><R><G><D><G><P><F><R><L><G><G><H><G><P><S><F><P><L><K><G><I><T><E><Q><Q><K><E><G><L><E><I><V><K><M><V><M><I><S><L><E><G><E><D><G><L><D><E><I><Y><S><F><S><E><S><L><R><K><L><C><V><F><K><K><I><E><R><H><S><I><H><W><P><C><R><L><T><I><G><S><N><L><S><I><R><I><A><A><Y><K><S><I><L><Q><E><R><V><K><K><T><W><T><V><V><D><A><K><T><L><K><K><E><D><I><Q><K><E><T><V><Y><C><L><N><D><D><D><E><T><E><V><L><K><E><D><I><I><Q><G><F><R><Y><G><S><D><I><V><P><F><S><K><V><D><E><E><Q><M><K><Y><K><S><E><G><K><C><F><S><V><L><G><F><C><K><S><S><Q><V><Q><R><R><F><F><M><G><N><Q><V><L><K><V><F><A><A><R><D><D><E><A><A><A><V><A><L><S><S><L><I><H><A><L><D><D><L><D><M><V><A><I><V><R><Y><A><Y><D><K><R><A><N><P><Q><V><G><V><A><F><P><H><I><K><H><N><Y><E><C><L><V><Y><V><Q><L><P><F><M><E><D><L><R><Q><Y><M><F><S><S><L><K><N><S><K><K><Y><A><P><T><E><A><Q><L><N><A><V><D><A><L><I><D><S><M><S><L><A><K><K><D><E><K><T><D><T><L><E><D><L><F><P><T><T><K><I><P><N><P><R><F><Q><R><L><F><Q><C><L><L><H><R><A><L><H><P><R><E><P><L><P><P><I><Q><Q><H><I><W><N><M><L><N><P><P><A><E><V><T><T><K><S><Q><I><P><L><S><K><I><K><T><L><F><P><L><I><E><A><K><K><K><D><Q><V><T><A><Q><E><I><F><Q><D><N><H><E><D><G><P><T><A><K><K><L><K><T><E><Q><G><G><A><H><F><S><V><S><S><L><A><E><G><S><V><T><S><V><G><S><V><N><P><A><E><N><F><R><V><L><V><K><Q><K><K><A><S><F><E><E><A><S><N><Q><L><I><N><H><I><E><Q><F><L><D><T><N><E><T><P><Y><F><M><K><S><I><D><C><I><R><A><F><R><E><E><A><I><K><F><S><E><E><Q><R><F><N><N><F><L><K><A><L><Q><E><K><V><E><I><K><Q><L><N><H><F><W><E><I><V><V><Q><D><G><I><T><L><I><T><K><E><E><A><S><G><S><S><V><T><A><E><E><A><K><K><F><L><A><P><K><D><K><P><S><G><D><T><A><A><V><F><E><E><G><G><D><V><D><D><L><L><D><M><I>
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA . Required for double-strand break repair and V(D)J recombination . Also has a role in chromosome translocation . The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner . It works in the 3'-5' direction . During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection . Binding to DNA may be mediated by XRCC6 . The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold . The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together . The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step . The XRCC5-XRRC6 dimer probably also acts as a
P13010
O15431
COPT1_HUMAN
Solute carrier family 31 member 1
Homo
<M><D><H><S><H><H><M><G><M><S><Y><M><D><S><N><S><T><M><Q><P><S><H><H><H><P><T><T><S><A><S><H><S><H><G><G><G><D><S><S><M><M><M><M><P><M><T><F><Y><F><G><F><K><N><V><E><L><L><F><S><G><L><V><I><N><T><A><G><E><M><A><G><A><F><V><A><V><F><L><L><A><M><F><Y><E><G><L><K><I><A><R><E><S><L><L><R><K><S><Q><V><S><I><R><Y><N><S><M><P><V><P><G><P><N><G><T><I><L><M><E><T><H><K><T><V><G><Q><Q><M><L><S><F><P><H><L><L><Q><T><V><L><H><I><I><Q><V><V><I><S><Y><F><L><M><L><I><F><M><T><Y><N><G><Y><L><C><I><A><V><A><A><G><A><G><T><G><Y><F><L><F><S><W><K><K><A><V><V><V><D><I><T><E><H><C><H>
High-affinity, saturable copper transporter involved in dietary copper uptake.<BOP>
O15431
Q96IZ5
RBM41_HUMAN
RNA-binding motif protein 41
Homo
<M><K><R><V><N><S><C><V><K><S><D><E><H><V><L><E><E><L><E><T><E><G><E><R><Q><L><K><S><L><L><Q><H><Q><L><D><T><S><V><S><I><E><E><C><M><S><K><K><E><S><F><A><P><G><T><M><Y><K><P><F><G><K><E><A><A><G><T><M><T><L><S><Q><F><Q><T><L><H><E><K><D><Q><E><T><A><S><L><R><E><L><G><L><N><E><T><E><I><L><I><W><K><S><H><V><S><G><E><K><K><T><K><L><R><A><T><P><E><A><I><Q><N><R><L><Q><D><I><E><E><R><I><S><E><R><Q><R><I><L><C><L><P><Q><R><F><A><K><S><K><Q><L><T><R><R><E><M><E><I><E><K><S><L><F><Q><G><A><D><R><H><S><F><L><K><A><L><Y><Y><Q><D><E><P><Q><K><K><N><K><G><D><P><M><N><N><L><E><S><F><Y><Q><E><M><I><M><K><K><R><L><E><E><F><Q><L><M><R><G><E><P><F><A><S><H><S><L><V><S><A><T><S><V><G><D><S><G><T><A><E><S><P><S><L><L><Q><D><K><G><K><Q><A><A><Q><G><K><G><P><S><L><H><V><A><N><V><I><D><F><S><P><E><Q><C><W><T><G><P><K><K><L><T><Q><P><I><E><F><V><P><E><D><E><I><Q><R><N><R><L><S><E><E><E><I><R><K><I><P><M><F><S><S><Y><N><P><G><E><P><N><K><V><L><Y><L><K><N><L><S><P><R><V><T><E><R><D><L><V><S><L><F><A><R><F><Q><E><K><K><G><P><P><I><Q><F><R><M><M><T><G><R><M><R><G><Q><A><F><I><T><F><P><N><K><E><I><A><W><Q><A><L><H><L><V><N><G><Y><K><L><H><G><K><I><L><V><I><E><F><G><K><N><K><K><Q><R><S><N><L><Q><A><T><S><L><I><S><C><A><T><G><S><T><T><E><I><S><G><S>
May bind RNA.<BOP>
Q96IZ5
Q0GE19
NTCP7_HUMAN
Solute carrier family 10 member 7
Homo
<M><R><L><L><E><R><M><R><K><D><W><F><M><V><G><I><V><L><A><I><A><G><A><K><L><E><P><S><I><G><V><N><G><G><P><L><K><P><E><I><T><V><S><Y><I><A><V><A><T><I><F><F><N><S><G><L><S><L><K><T><E><E><L><T><S><A><L><V><H><L><K><L><H><L><F><I><Q><I><F><T><L><A><F><F><P><A><T><I><W><L><F><L><Q><L><L><S><I><T><P><I><N><E><W><L><L><K><G><L><Q><T><V><G><C><M><P><P><P><V><S><S><A><V><I><L><T><K><A><V><G><G><N><E><A><A><A><I><F><N><S><A><F><G><S><F><L><G><I><V><I><T><P><L><L><L><L><L><F><L><G><S><S><S><S><V><P><F><T><S><I><F><S><Q><L><F><M><T><V><V><V><P><L><I><I><G><Q><I><V><R><R><Y><I><K><D><W><L><E><R><K><K><P><P><F><G><A><I><S><S><S><V><L><L><M><I><I><Y><T><T><F><C><D><T><F><S><N><P><N><I><D><L><D><K><F><S><L><V><L><I><L><F><I><I><F><S><I><Q><L><S><F><M><L><L><T><F><I><F><S><T><R><N><N><S><G><F><T><P><A><D><T><V><A><I><I><F><C><S><T><H><K><S><L><T><L><G><I><P><M><L><K><I><V><F><A><G><H><E><H><L><S><L><I><S><V><P><L><L><I><Y><H><P><A><Q><I><L><L><G><S><V><L><V><P><T><I><K><S><W><M><V><S><R><Q><K><G><V><K><L><T><R><P><T><V>
Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization . Also involved in the regulation of cellular calcium homeostasis . Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate).<BOP>
Q0GE19
Q8IWW8
HOT_HUMAN
Fe-containing alcohol dehydrogenase
Homo
<M><A><A><A><A><R><A><R><V><A><Y><L><L><R><Q><L><Q><R><A><A><C><Q><C><P><T><H><S><H><T><Y><S><Q><A><P><G><L><S><P><S><G><K><T><T><D><Y><A><F><E><M><A><V><S><N><I><R><Y><G><A><A><V><T><K><E><V><G><M><D><L><K><N><M><G><A><K><N><V><C><L><M><T><D><K><N><L><S><K><L><P><P><V><Q><V><A><M><D><S><L><V><K><N><G><I><P><F><T><V><Y><D><N><V><R><V><E><P><T><D><S><S><F><M><E><A><I><E><F><A><Q><K><G><A><F><D><A><Y><V><A><V><G><G><G><S><T><M><D><T><C><K><A><A><N><L><Y><A><S><S><P><H><S><D><F><L><D><Y><V><S><A><P><I><G><K><G><K><P><V><S><V><P><L><K><P><L><I><A><V><P><T><T><S><G><T><G><S><E><T><T><G><V><A><I><F><D><Y><E><H><L><K><V><K><I><G><I><T><S><R><A><I><K><P><T><L><G><L><I><D><P><L><H><T><L><H><M><P><A><R><V><V><A><N><S><G><F><D><V><L><C><H><A><L><E><S><Y><T><T><L><P><Y><H><L><R><S><P><C><P><S><N><P><I><T><R><P><A><Y><Q><G><S><N><P><I><S><D><I><W><A><I><H><A><L><R><I><V><A><K><Y><L><K><R><A><V><R><N><P><D><D><L><E><A><R><S><H><M><H><L><A><S><A><F><A><G><I><G><F><G><N><A><G><V><H><L><C><H><G><M><S><Y><P><I><S><G><L><V><K><M><Y><K><A><K><D><Y><N><V><D><H><P><L><V><P><H><G><L><S><V><V><L><T><S><P><A><V><F><T><F><T><A><Q><M><F><P><E><R><H><L><E><M><A><E><I><L><G><A><D><T><R><T><A><R><I><Q><D><A><G><L><V><L><A><D><T><L><R><K><F><L><F><D><L><D><V><D><D><G><L><A><A><V><G><Y><S><K><A><D><I><P><A><L><V><K><G><T><L><P><Q><E><R><V><T><K><L><A><P><C><P><Q><S><E><E><D><L><A><A><L><F><E><A><S><M><K><L><Y>
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.<BOP>
Q8IWW8
Q9NTW7
ZF64B_HUMAN
Zinc finger protein 338
Homo
<M><N><A><S><S><E><G><E><S><F><A><G><S><V><Q><I><P><G><G><T><T><V><L><V><E><L><T><P><D><I><H><I><C><G><I><C><K><Q><Q><F><N><N><L><D><A><F><V><A><H><K><Q><S><G><C><Q><L><T><G><T><S><A><A><A><P><S><T><V><Q><F><V><S><E><E><T><V><P><A><T><Q><T><Q><T><T><T><R><T><I><T><S><E><T><Q><T><I><T><V><S><A><P><E><F><V><F><E><H><G><Y><Q><T><Y><L><P><T><E><S><N><E><N><Q><T><A><T><V><I><S><L><P><A><K><S><R><T><K><K><P><T><T><P><P><A><Q><K><R><L><N><C><C><Y><P><G><C><Q><F><K><T><A><Y><G><M><K><D><M><E><R><H><L><K><I><H><T><G><D><K><P><H><K><C><E><V><C><G><K><C><F><S><R><K><D><K><L><K><T><H><M><R><C><H><T><G><V><K><P><Y><K><C><K><T><C><D><Y><A><A><A><D><S><S><S><L><N><K><H><L><R><I><H><S><D><E><R><P><F><K><C><Q><I><C><P><Y><A><S><R><N><S><S><Q><L><T><V><H><L><R><S><H><T><A><S><E><L><D><D><D><V><P><K><A><N><C><L><S><T><E><S><T><D><T><P><K><A><P><V><I><T><L><P><S><E><A><R><E><Q><M><A><T><L><G><E><R><T><F><N><C><C><Y><P><G><C><H><F><K><T><V><H><G><M><K><D><L><D><R><H><L><R><I><H><T><G><D><K><P><H><K><C><E><F><C><D><K><C><F><S><R><K><D><N><L><T><M><H><M><R><C><H><T><S><V><K><P><H><K><C><H><L><C><D><Y><A><A><V><D><S><S><S><L><K><K><H><L><R><I><H><S><D><E><R><P><Y><K><C><Q><L><C><P><Y><A><S><R><N><S><S><Q><L><T><V><H><L><R><S><H><T><G><D><T><P><F><Q><C><W><L><C><S><A><K><F><K><I><S><S><D><L><K><R><H><M><I><V><H><S><G><E><K><P><F><K><C><E><F><C><D><V><R><C><T><M><K><A><N><L><K><S><H><I><R><I><K><H><T><F><K><C><L><H><C><A><F><Q><G><R><D><R><A><D><L><L><E><H><S><R><L><H><Q><A><D><H><P><E><K><C><P><E><C><S><Y><S><C><S><S><A><A><A><L><R><V><H><S><R><V><H><C><K><D><R><P><F><K><C><D><F><C><S><F><D><T><K><R><P><S><S><L><A><K><H><V><D><K><V><H><R><D><E><A><K><T><E><N><R><A><P><L><G><K><E><G><L><R><E><G><S><S><Q><H><V><A><K><I><V><T><Q><R><A><F><R><C><E><T><C><G><A><S><F><V><R><D><D><S><L><R><C><H><K><K><Q><H><S><D><Q><S><E><N><K><N><S><D><L><V><T><F><P><P><E><S><G><A><S><G><Q><L><S><T><L><V><S><V><G><Q><L><E><A><P><L><E><P><S><Q><D><L>
May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes.<BOP>
Q9NTW7
Q9BRQ8
FSP1_HUMAN
p53-responsive gene 3 protein
Homo
<M><G><S><Q><V><S><V><E><S><G><A><L><H><V><V><I><V><G><G><G><F><G><G><I><A><A><A><S><Q><L><Q><A><L><N><V><P><F><M><L><V><D><M><K><D><S><F><H><H><N><V><A><A><L><R><A><S><V><E><T><G><F><A><K><K><T><F><I><S><Y><S><V><T><F><K><D><N><F><R><Q><G><L><V><V><G><I><D><L><K><N><Q><M><V><L><L><Q><G><G><E><A><L><P><F><S><H><L><I><L><A><T><G><S><T><G><P><F><P><G><K><F><N><E><V><S><S><Q><Q><A><A><I><Q><A><Y><E><D><M><V><R><Q><V><Q><R><S><R><F><I><V><V><V><G><G><G><S><A><G><V><E><M><A><A><E><I><K><T><E><Y><P><E><K><E><V><T><L><I><H><S><Q><V><A><L><A><D><K><E><L><L><P><S><V><R><Q><E><V><K><E><I><L><L><R><K><G><V><Q><L><L><L><S><E><R><V><S><N><L><E><E><L><P><L><N><E><Y><R><E><Y><I><K><V><Q><T><D><K><G><T><E><V><A><T><N><L><V><I><L><C><T><G><I><K><I><N><S><S><A><Y><R><K><A><F><E><S><R><L><A><S><S><G><A><L><R><V><N><E><H><L><Q><V><E><G><H><S><N><V><Y><A><I><G><D><C><A><D><V><R><T><P><K><M><A><Y><L><A><G><L><H><A><N><I><A><V><A><N><I><V><N><S><V><K><Q><R><P><L><Q><A><Y><K><P><G><A><L><T><F><L><L><S><M><G><R><N><D><G><V><G><Q><I><S><G><F><Y><V><G><R><L><M><V><R><L><T><K><S><R><D><L><F><V><S><T><S><W><K><T><M><R><Q><S><P><P>
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels . May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death . Capable of DNA binding in a non-sequence specific way .<BOP>
Q9BRQ8
Q8IYA8
IHO1_HUMAN
Coiled-coil domain-containing protein 36
Homo
<M><N><F><N><V><W><N><I><K><E><M><L><S><I><P><S><G><S><G><N><K><K><S><S><N><W><N><N><N><Q><N><D><Y><S><S><L><S><D><S><Q><F><L><F><G><S><Q><F><C><P><E><N><S><E><T><L><S><A><P><L><D><F><G><A><H><L><R><H><S><K><Q><S><Q><Q><N><Y><L><E><G><E><P><S><I><F><T><K><Y><Q><T><K><P><Q><L><F><G><G><D><I><K><D><G><G><L><F><P><P><P><L><S><V><G><K><S><K><G><L><L><E><Q><F><E><E><K><K><K><R><A><K><D><K><C><D><S><E><T><L><Y><N><F><V><S><N><V><R><E><S><I><L><R><L><Q><T><S><V><E><K><S><E><D><H><L><S><S><R><S><Q><S><I><L><D><S><L><E><T><V><A><K><T><L><Q><E><T><I><Q><A><Q><N><D><L><V><F><E><A><V><Q><D><K><G><N><M><E><Q><A><I><L><E><M><K><K><R><F><E><A><R><Q><G><E><F><I><E><M><K><S><N><L><K><H><L><E><V><L><V><A><Q><Q><S><Q><E><F><Q><Q><L><C><E><Q><L><G><Q><L><N><V><P><S><V><L><A><E><L><K><R><L><I><S><V><P><P><V><K><D><S><A><S><Q><T><S><P><P><L><A><Q><S><L><N><L><T><R><Q><E><K><Y><T><S><E><K><P><V><L><W><Q><A><Q><A><L><P><A><A><W><N><P><G><M><G><S><L><Q><P><G><E><F><D><V><W><G><E><G><A><K><N><D><D><L><Q><E><E><A><A><L><P><A><F><G><S><H><E><R><N><R><H><V><K><D><K><V><V><Q><T><N><C><K><N><W><A><V><T><K><T><G><A><K><N><H><G><S><S><V><P><G><H><K><I><P><S><D><R><D><L><V><S><Q><G><A><S><Q><L><T><S><L><E><I><N><F><S><T><S><I><K><N><A><C><Q><K><Y><Q><A><Q><S><M><F><L><C><D><P><R><E><H><L><V><I><K><Q><K><D><G><T><V><E><M><R><G><K><D><K><K><Q><Q><P><R><K><A><H><R><A><H><R><G><R><L><I><A><S><K><Q><K><Q><I><P><I><Q><T><C><K><F><N><S><K><Y><Q><S><P><Q><P><A><I><S><V><P><Q><S><P><F><L><G><Q><Q><E><P><R><A><Q><P><L><H><L><Q><C><P><R><S><P><R><K><P><V><C><P><I><L><G><G><T><V><M><P><N><K><T><V><R><A><V><Q><G><R><L><L><Q><L><S><R><C><S><S><Q><D><N><W><L><L><S><S><S><S><Q><G><D><H><Q><M><S><W><F><S><D><L><N><L><G><C><S><E><T><P><L><C><K><E><A><G><K><N><L><L><Y><D><L><G><F><D><S><S><D><D><D><G><F>
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.<BOP>
Q8IYA8
Q8NFZ8
CADM4_HUMAN
TSLC1-like protein 2
Homo
<M><G><R><A><R><R><F><Q><W><P><L><L><L><L><W><A><A><A><A><G><P><G><A><G><Q><E><V><Q><T><E><N><V><T><V><A><E><G><G><V><A><E><I><T><C><R><L><H><Q><Y><D><G><S><I><V><V><I><Q><N><P><A><R><Q><T><L><F><F><N><G><T><R><A><L><K><D><E><R><F><Q><L><E><E><F><S><P><R><R><V><R><I><R><L><S><D><A><R><L><E><D><E><G><G><Y><F><C><Q><L><Y><T><E><D><T><H><H><Q><I><A><T><L><T><V><L><V><A><P><E><N><P><V><V><E><V><R><E><Q><A><V><E><G><G><E><V><E><L><S><C><L><V><P><R><S><R><P><A><A><T><L><R><W><Y><R><D><R><K><E><L><K><G><V><S><S><S><Q><E><N><G><K><V><W><S><V><A><S><T><V><R><F><R><V><D><R><K><D><D><G><G><I><I><I><C><E><A><Q><N><Q><A><L><P><S><G><H><S><K><Q><T><Q><Y><V><L><D><V><Q><Y><S><P><T><A><R><I><H><A><S><Q><A><V><V><R><E><G><D><T><L><V><L><T><C><A><V><T><G><N><P><R><P><N><Q><I><R><W><N><R><G><N><E><S><L><P><E><R><A><E><A><V><G><E><T><L><T><L><P><G><L><V><S><A><D><N><G><T><Y><T><C><E><A><S><N><K><H><G><H><A><R><A><L><Y><V><L><V><V><Y><D><P><G><A><V><V><E><A><Q><T><S><V><P><Y><A><I><V><G><G><I><L><A><L><L><V><F><L><I><I><C><V><L><V><G><M><V><W><C><S><V><R><Q><K><G><S><Y><L><T><H><E><A><S><G><L><D><E><Q><G><E><A><R><E><A><F><L><N><G><S><D><G><H><K><R><K><E><E><F><F><I>
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.<BOP>
Q8NFZ8
Q9Y2Y8
PRG3_HUMAN
Prepro-major basic protein homolog
Homo
<M><Q><C><L><L><L><L><P><F><L><L><L><G><T><V><S><A><L><H><L><E><N><D><A><P><H><L><E><S><L><E><T><Q><A><D><L><G><Q><D><L><D><S><S><K><E><Q><E><R><D><L><A><L><T><E><E><V><I><Q><A><E><G><E><E><V><K><A><S><A><C><Q><D><N><F><E><D><E><E><A><M><E><S><D><P><A><A><L><D><K><D><F><Q><C><P><R><E><E><D><I><V><E><V><Q><G><S><P><R><C><K><I><C><R><Y><L><L><V><R><T><P><K><T><F><A><E><A><Q><N><V><C><S><R><C><Y><G><G><N><L><V><S><I><H><D><F><N><F><N><Y><R><I><Q><C><C><T><S><T><V><N><Q><A><Q><V><W><I><G><G><N><L><R><G><W><F><L><W><K><R><F><C><W><T><D><G><S><H><W><N><F><A><Y><W><S><P><G><Q><P><G><N><G><Q><G><S><C><V><A><L><C><T><K><G><G><Y><W><R><R><A><Q><C><D><K><Q><L><P><F><V><C><S><F>
Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.<BOP>
Q9Y2Y8
O15467
CCL16_HUMAN
Small-inducible cytokine A16
Homo
<M><K><V><S><E><A><A><L><S><L><L><V><L><I><L><I><I><T><S><A><S><R><S><Q><P><K><V><P><E><W><V><N><T><P><S><T><C><C><L><K><Y><Y><E><K><V><L><P><R><R><L><V><V><G><Y><R><K><A><L><N><C><H><L><P><A><I><I><F><V><T><K><R><N><R><E><V><C><T><N><P><N><D><D><W><V><Q><E><Y><I><K><D><P><N><L><P><L><L><P><T><R><N><L><S><T><V><K><I><I><T><A><K><N><G><Q><P><Q><L><L><N><S><Q>
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.<BOP>
O15467
O15062
ZBTB5_HUMAN
Zinc finger and BTB domain-containing protein 5
Homo
<M><D><F><P><G><H><F><E><Q><I><F><Q><Q><L><N><Y><Q><R><L><H><G><Q><L><C><D><C><V><I><V><V><G><N><R><H><F><K><A><H><R><S><V><L><A><A><C><S><T><H><F><R><A><L><F><S><V><A><E><G><D><Q><T><M><N><M><I><Q><L><D><S><E><V><V><T><A><E><A><F><A><A><L><I><D><M><M><Y><T><S><T><L><M><L><G><E><S><N><V><M><D><V><L><L><A><A><S><H><L><H><L><N><S><V><V><K><A><C><K><H><Y><L><T><T><R><T><L><P><M><S><P><P><S><E><R><V><Q><E><Q><S><A><R><M><Q><R><S><F><M><L><Q><Q><L><G><L><S><I><V><S><S><A><L><N><S><S><Q><N><G><E><E><Q><P><A><P><M><S><S><S><M><R><S><N><L><D><Q><R><T><P><F><P><M><R><R><L><H><K><R><K><Q><S><A><E><E><R><A><R><Q><R><L><R><P><S><I><D><E><S><A><I><S><D><V><T><P><E><N><G><P><S><G><V><H><S><R><E><E><F><F><S><P><D><S><L><K><I><V><D><N><P><K><A><D><G><M><T><D><N><Q><E><D><S><A><I><M><F><D><Q><S><F><G><T><Q><E><D><A><Q><V><P><S><Q><S><D><N><S><A><G><N><M><A><Q><L><S><M><A><S><R><A><T><Q><V><E><T><S><F><D><Q><E><A><A><P><E><K><S><S><F><Q><C><E><N><P><E><V><G><L><G><E><K><E><H><M><R><V><V><V><K><S><E><P><L><S><S><P><E><P><Q><D><E><V><S><D><V><T><S><Q><A><E><G><S><E><S><V><E><V><E><G><V><V><V><S><A><E><K><I><D><L><S><P><E><S><S><D><R><S><F><S><D><P><Q><S><S><T><D><R><V><G><D><I><H><I><L><E><V><T><N><N><L><E><H><K><S><T><F><S><I><S><N><F><L><N><K><S><R><G><N><N><F><T><A><N><Q><N><N><D><D><N><I><P><N><T><T><S><D><C><R><L><E><S><E><A><P><Y><L><L><S><P><E><A><G><P><A><G><G><P><S><S><A><P><G><S><H><V><E><N><P><F><S><E><P><A><D><S><H><F><V><R><P><M><Q><E><V><M><G><L><P><C><V><Q><T><S><G><Y><Q><G><G><E><Q><F><G><M><D><F><S><R><S><G><L><G><L><H><S><S><F><S><R><V><M><I><G><S><P><R><G><G><A><S><N><F><P><Y><Y><R><R><I><A><P><K><M><P><V><V><T><S><V><R><S><S><Q><I><P><E><N><S><T><S><S><Q><L><M><M><N><G><A><T><S><S><F><E><N><G><H><P><S><Q><P><G><P><P><Q><L><T><R><A><S><A><D><V><L><S><K><C><K><K><A><L><S><E><H><N><V><L><V><V><E><G><A><R><K><Y><A><C><K><I><C><C><K><T><F><L><T><L><T><D><C><K><K><H><I><R><V><H><T><G><E><K><P><Y><A><C><L><K><C><G><K><R><F><S><Q><S><S><H><L><Y><K><H><S><K><T><T><C><L><R><W><Q><S><S><N><L><P><S><T><L><L>
May be involved in transcriptional regulation.<BOP>
O15062
Q96A28
SLAF9_HUMAN
CD84 homolog 1
Homo
<M><C><A><F><P><W><L><L><L><L><L><L><L><Q><E><G><S><Q><R><R><L><W><R><W><C><G><S><E><E><V><V><A><V><L><Q><E><S><I><S><L><P><L><E><I><P><P><D><E><E><V><E><N><I><I><W><S><S><H><K><S><L><A><T><V><V><P><G><K><E><G><H><P><A><T><I><M><V><T><N><P><H><Y><Q><G><Q><V><S><F><L><D><P><S><Y><S><L><H><I><S><N><L><S><W><E><D><S><G><L><Y><Q><A><Q><V><N><L><R><T><S><Q><I><S><T><M><Q><Q><Y><N><I><C><V><Y><R><W><L><S><E><P><Q><I><T><V><N><F><E><S><S><G><E><G><A><C><S><M><S><L><V><C><S><V><E><K><A><G><M><D><M><T><Y><S><W><L><S><R><G><D><S><T><Y><T><F><H><E><G><P><V><L><S><T><S><W><R><P><G><D><S><A><L><S><Y><T><C><R><A><N><N><P><I><S><N><V><S><S><C><P><I><P><D><G><P><F><Y><A><D><P><N><Y><A><S><E><K><P><S><T><A><F><C><L><L><A><K><G><L><L><I><F><L><L><L><V><I><L><A><M><G><L><W><V><I><R><V><Q><K><R><H><K><M><P><R><M><K><K><L><M><R><N><R><M><K><L><R><K><E><A><K><P><G><S><S><P><A>
May play a role in the immune response.<BOP>
Q96A28
Q8NH69
OR5W2_HUMAN
Olfactory receptor OR11-155
Homo
<M><D><W><E><N><C><S><S><L><T><D><F><F><L><L><G><I><T><N><N><P><E><M><K><V><T><L><F><A><V><F><L><A><V><Y><I><I><N><F><S><A><N><L><G><M><I><V><L><I><R><M><D><Y><Q><L><H><T><P><M><Y><F><F><L><S><H><L><S><F><C><D><L><C><Y><S><T><A><T><G><P><K><M><L><V><D><L><L><A><K><N><K><S><I><P><F><Y><G><C><A><L><Q><F><L><V><F><C><I><F><A><D><S><E><C><L><L><L><S><V><M><A><F><D><R><Y><K><A><I><I><N><P><L><L><Y><T><V><N><M><S><S><R><V><C><Y><L><L><L><T><G><V><Y><L><V><G><I><A><D><A><L><I><H><M><T><L><A><F><R><L><C><F><C><G><S><N><E><I><N><H><F><F><C><D><I><P><P><L><L><L><L><S><R><S><D><T><Q><V><N><E><L><V><L><F><T><V><F><G><F><I><E><L><S><T><I><S><G><V><F><I><S><Y><C><Y><I><I><L><S><V><L><E><I><H><S><A><E><G><R><F><K><A><L><S><T><C><T><S><H><L><S><A><V><A><I><F><Q><G><T><L><L><F><M><Y><F><R><P><S><S><S><Y><S><L><D><Q><D><K><M><T><S><L><F><Y><T><L><V><V><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><E><A><L><K><K><L><K><N><K><I><L><F>
Odorant receptor.<BOP>
Q8NH69
Q9H237
PORCN_HUMAN
Protein MG61
Homo
<M><A><T><F><S><R><Q><E><F><F><Q><Q><L><L><Q><G><C><L><L><P><T><A><Q><Q><G><L><D><Q><I><W><L><L><L><A><I><C><L><A><C><R><L><L><W><R><L><G><L><P><S><Y><L><K><H><A><S><T><V><A><G><G><F><F><S><L><Y><H><F><F><Q><L><H><M><V><W><V><V><L><L><S><L><L><C><Y><L><V><L><F><L><C><R><H><S><S><H><R><G><V><F><L><S><V><T><I><L><I><Y><L><L><M><G><E><M><H><M><V><D><T><V><T><W><H><K><M><R><G><A><Q><M><I><V><A><M><K><A><V><S><L><G><F><D><L><D><R><G><E><V><G><T><V><P><S><P><V><E><F><M><G><Y><L><Y><F><V><G><T><I><V><F><G><P><W><I><S><F><H><S><Y><L><Q><A><V><Q><G><R><P><L><S><C><R><W><L><Q><K><V><A><R><S><L><A><L><A><L><L><C><L><V><L><S><T><C><V><G><P><Y><L><F><P><Y><F><I><P><L><N><G><D><R><L><L><R><N><K><K><R><K><A><R><G><T><M><V><R><W><L><R><A><Y><E><S><A><V><S><F><H><F><S><N><Y><F><V><G><F><L><S><E><A><T><A><T><L><A><G><A><G><F><T><E><E><K><D><H><L><E><W><D><L><T><V><S><K><P><L><N><V><E><L><P><R><S><M><V><E><V><V><T><S><W><N><L><P><M><S><Y><W><L><N><N><Y><V><F><K><N><A><L><R><L><G><T><F><S><A><V><L><V><T><Y><A><A><S><A><L><L><H><G><F><S><F><H><L><A><A><V><L><L><S><L><A><F><I><T><Y><V><E><H><V><L><R><K><R><L><A><R><I><L><S><A><C><V><L><S><K><R><C><P><P><D><C><S><H><Q><H><R><L><G><L><G><V><R><A><L><N><L><L><F><G><A><L><A><I><F><H><L><A><Y><L><G><S><L><F><D><V><D><V><D><D><T><T><E><E><Q><G><Y><G><M><A><Y><T><V><H><K><W><S><E><L><S><W><A><S><H><W><V><T><F><G><C><W><I><F><Y><R><L><I><G>
Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.<BOP>
Q9H237
Q9H173
SIL1_HUMAN
BiP-associated protein
Homo
<M><A><P><Q><S><L><P><S><S><R><M><A><P><L><G><M><L><L><G><L><L><M><A><A><C><F><T><F><C><L><S><H><Q><N><L><K><E><F><A><L><T><N><P><E><K><S><S><T><K><E><T><E><R><K><E><T><K><A><E><E><E><L><D><A><E><V><L><E><V><F><H><P><T><H><E><W><Q><A><L><Q><P><G><Q><A><V><P><A><G><S><H><V><R><L><N><L><Q><T><G><E><R><E><A><K><L><Q><Y><E><D><K><F><R><N><N><L><K><G><K><R><L><D><I><N><T><N><T><Y><T><S><Q><D><L><K><S><A><L><A><K><F><K><E><G><A><E><M><E><S><S><K><E><D><K><A><R><Q><A><E><V><K><R><L><F><R><P><I><E><E><L><K><K><D><F><D><E><L><N><V><V><I><E><T><D><M><Q><I><M><V><R><L><I><N><K><F><N><S><S><S><S><S><L><E><E><K><I><A><A><L><F><D><L><E><Y><Y><V><H><Q><M><D><N><A><Q><D><L><L><S><F><G><G><L><Q><V><V><I><N><G><L><N><S><T><E><P><L><V><K><E><Y><A><A><F><V><L><G><A><A><F><S><S><N><P><K><V><Q><V><E><A><I><E><G><G><A><L><Q><K><L><L><V><I><L><A><T><E><Q><P><L><T><A><K><K><K><V><L><F><A><L><C><S><L><L><R><H><F><P><Y><A><Q><R><Q><F><L><K><L><G><G><L><Q><V><L><R><T><L><V><Q><E><K><G><T><E><V><L><A><V><R><V><V><T><L><L><Y><D><L><V><T><E><K><M><F><A><E><E><E><A><E><L><T><Q><E><M><S><P><E><K><L><Q><Q><Y><R><Q><V><H><L><L><P><G><L><W><E><Q><G><W><C><E><I><T><A><H><L><L><A><L><P><E><H><D><A><R><E><K><V><L><Q><T><L><G><V><L><L><T><T><C><R><D><R><Y><R><Q><D><P><Q><L><G><R><T><L><A><S><L><Q><A><E><Y><Q><V><L><A><S><L><E><L><Q><D><G><E><D><E><G><Y><F><Q><E><L><L><G><S><V><N><S><L><L><K><E><L><R>
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.<BOP>
Q9H173
O14764
GBRD_HUMAN
GABA(A) receptor subunit delta
Homo
<M><D><A><P><A><R><L><L><A><P><L><L><L><L><C><A><Q><Q><L><R><G><T><R><A><M><N><D><I><G><D><Y><V><G><S><N><L><E><I><S><W><L><P><N><L><D><G><L><I><A><G><Y><A><R><N><F><R><P><G><I><G><G><P><P><V><N><V><A><L><A><L><E><V><A><S><I><D><H><I><S><E><A><N><M><E><Y><T><M><T><V><F><L><H><Q><S><W><R><D><S><R><L><S><Y><N><H><T><N><E><T><L><G><L><D><S><R><F><V><D><K><L><W><L><P><D><T><F><I><V><N><A><K><S><A><W><F><H><D><V><T><V><E><N><K><L><I><R><L><Q><P><D><G><V><I><L><Y><S><I><R><I><T><S><T><V><A><C><D><M><D><L><A><K><Y><P><M><D><E><Q><E><C><M><L><D><L><E><S><Y><G><Y><S><S><E><D><I><V><Y><Y><W><S><E><S><Q><E><H><I><H><G><L><D><K><L><Q><L><A><Q><F><T><I><T><S><Y><R><F><T><T><E><L><M><N><F><K><S><A><G><Q><F><P><R><L><S><L><H><F><H><L><R><R><N><R><G><V><Y><I><I><Q><S><Y><M><P><S><V><L><L><V><A><M><S><W><V><S><F><W><I><S><Q><A><A><V><P><A><R><V><S><L><G><I><T><T><V><L><T><M><T><T><L><M><V><S><A><R><S><S><L><P><R><A><S><A><I><K><A><L><D><V><Y><F><W><I><C><Y><V><F><V><F><A><A><L><V><E><Y><A><F><A><H><F><N><A><D><Y><R><K><K><Q><K><A><K><V><K><V><S><R><P><R><A><E><M><D><V><R><N><A><I><V><L><F><S><L><S><A><A><G><V><T><Q><E><L><A><I><S><R><R><Q><R><R><V><P><G><N><L><M><G><S><Y><R><S><V><G><V><E><T><G><E><T><K><K><E><G><A><A><R><S><G><G><Q><G><G><I><R><A><R><L><R><P><I><D><A><D><T><I><D><I><Y><A><R><A><V><F><P><A><A><F><A><A><V><N><V><I><Y><W><A><A><Y><A><M>
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP>
O14764
Q2TAA5
ALG11_HUMAN
Glycolipid 2-alpha-mannosyltransferase
Homo
<M><A><A><G><E><R><S><W><C><L><C><K><L><L><R><F><F><Y><S><L><F><F><P><G><L><I><V><C><G><T><L><C><V><C><L><V><I><V><L><W><G><I><R><L><L><L><Q><R><K><K><K><L><V><S><T><S><K><N><G><K><N><Q><M><V><I><A><F><F><H><P><Y><C><N><A><G><G><G><G><E><R><V><L><W><C><A><L><R><A><L><Q><K><K><Y><P><E><A><V><Y><V><V><Y><T><G><D><V><N><V><N><G><Q><Q><I><L><E><G><A><F><R><R><F><N><I><R><L><I><H><P><V><Q><F><V><F><L><R><K><R><Y><L><V><E><D><S><L><Y><P><H><F><T><L><L><G><Q><S><L><G><S><I><F><L><G><W><E><A><L><M><Q><C><V><P><D><V><Y><I><D><S><M><G><Y><A><F><T><L><P><L><F><K><Y><I><G><G><C><Q><V><G><S><Y><V><H><Y><P><T><I><S><T><D><M><L><S><V><V><K><N><Q><N><I><G><F><N><N><A><A><F><I><T><R><N><P><F><L><S><K><V><K><L><I><Y><Y><Y><L><F><A><F><I><Y><G><L><V><G><S><C><S><D><V><V><M><V><N><S><S><W><T><L><N><H><I><L><S><L><W><K><V><G><N><C><T><N><I><V><Y><P><P><C><D><V><Q><T><F><L><D><I><P><L><H><E><K><K><M><T><P><G><H><L><L><V><S><V><G><Q><F><R><P><E><K><N><H><P><L><Q><I><R><A><F><A><K><L><L><N><K><K><M><V><E><S><P><P><S><L><K><L><V><L><I><G><G><C><R><N><K><D><D><E><L><R><V><N><Q><L><R><R><L><S><E><D><L><G><V><Q><E><Y><V><E><F><K><I><N><I><P><F><D><E><L><K><N><Y><L><S><E><A><T><I><G><L><H><T><M><W><N><E><H><F><G><I><G><V><V><E><C><M><A><A><G><T><I><I><L><A><H><N><S><G><G><P><K><L><D><I><V><V><P><H><E><G><D><I><T><G><F><L><A><E><S><E><E><D><Y><A><E><T><I><A><H><I><L><S><M><S><A><E><K><R><L><Q><I><R><K><S><A><R><A><S><V><S><R><F><S><D><Q><E><F><E><V><T><F><L><S><S><V><E><K><L><F><K>
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.<BOP>
Q2TAA5
Q03405
UPAR_HUMAN
Monocyte activation antigen Mo3
Homo
<M><G><H><P><P><L><L><P><L><L><L><L><L><H><T><C><V><P><A><S><W><G><L><R><C><M><Q><C><K><T><N><G><D><C><R><V><E><E><C><A><L><G><Q><D><L><C><R><T><T><I><V><R><L><W><E><E><G><E><E><L><E><L><V><E><K><S><C><T><H><S><E><K><T><N><R><T><L><S><Y><R><T><G><L><K><I><T><S><L><T><E><V><V><C><G><L><D><L><C><N><Q><G><N><S><G><R><A><V><T><Y><S><R><S><R><Y><L><E><C><I><S><C><G><S><S><D><M><S><C><E><R><G><R><H><Q><S><L><Q><C><R><S><P><E><E><Q><C><L><D><V><V><T><H><W><I><Q><E><G><E><E><G><R><P><K><D><D><R><H><L><R><G><C><G><Y><L><P><G><C><P><G><S><N><G><F><H><N><N><D><T><F><H><F><L><K><C><C><N><T><T><K><C><N><E><G><P><I><L><E><L><E><N><L><P><Q><N><G><R><Q><C><Y><S><C><K><G><N><S><T><H><G><C><S><S><E><E><T><F><L><I><D><C><R><G><P><M><N><Q><C><L><V><A><T><G><T><H><E><P><K><N><Q><S><Y><M><V><R><G><C><A><T><A><S><M><C><Q><H><A><H><L><G><D><A><F><S><M><N><H><I><D><V><S><C><C><T><K><S><G><C><N><H><P><D><L><D><V><Q><Y><R><S><G><A><A><P><Q><P><G><P><A><H><L><S><L><T><I><T><L><L><M><T><A><R><L><W><G><G><T><L><L><W><T>
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.<BOP>
Q03405
A6NLW8
DUXA_HUMAN
Double homeobox protein A
Homo
<M><A><E><D><T><Y><S><H><K><M><V><K><T><N><H><R><R><C><R><T><K><F><T><E><E><Q><L><K><I><L><I><N><T><F><N><Q><K><P><Y><P><G><Y><A><T><K><Q><K><L><A><L><E><I><N><T><E><E><S><R><I><Q><I><W><F><Q><N><R><R><A><R><H><G><F><Q><K><R><P><E><A><E><T><L><E><S><S><Q><S><Q><G><Q><D><Q><P><G><V><E><F><Q><S><R><E><A><R><R><C><R><T><T><Y><S><A><S><Q><L><H><T><L><I><K><A><F><M><K><N><P><Y><P><G><I><D><S><R><E><E><L><A><K><E><I><G><V><P><E><S><R><V><Q><I><W><F><Q><N><R><R><S><R><L><L><L><Q><R><K><R><E><P><V><A><S><L><E><Q><E><E><Q><G><K><I><P><E><G><L><Q><G><A><E><D><T><Q><N><G><T><N><F><T><S><D><S><H><F><S><G><A><R><T><W>
Transcription factor that acts as repressor.<BOP>
A6NLW8