accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
P0CJ79
ZN888_HUMAN
Zinc finger protein 888
Homo
<M><A><L><P><Q><G><L><L><T><F><R><D><V><A><I><E><F><S><Q><E><E><W><K><C><L><D><P><A><Q><R><T><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><D><I><S><S><K><C><M><M><E><F><S><S><I><G><K><G><N><T><E><V><I><H><T><G><T><L><Q><R><L><A><S><H><H><I><G><E><C><C><F><Q><E><I><E><K><D><I><H><D><F><V><F><Q><W><Q><E><D><E><T><N><G><H><E><A><P><M><T><E><I><K><E><L><T><G><S><T><D><Q><Y><D><Q><R><H><A><G><N><K><P><I><K><Y><Q><L><G><S><S><F><H><S><H><L><P><E><L><H><I><F><Q><P><E><G><K><I><G><N><Q><L><E><K><S><I><N><N><A><S><S><V><S><T><S><Q><R><I><S><C><R><P><K><T><H><I><S><N><N><Y><G><N><N><F><F><H><S><S><L><L><T><Q><K><Q><D><V><H><R><K><E><K><S><F><Q><F><N><E><S><G><K><S><F><N><C><S><S><L><F><K><K><H><Q><I><I><H><L><G><E><K><Q><Y><K><C><D><V><C><G><K><D><F><N><Q><K><R><Y><L><A><H><H><R><R><C><H><T><G><E><K><P><Y><M><C><N><K><C><G><K><V><F><N><K><K><A><Y><L><A><R><H><Y><R><R><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><S><D><K><S><A><L><L><V><H><K><T><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><N><Q><Q><S><N><L><A><R><H><H><R><V><H><T><G><E><K><P><Y><Q><C><K><E><C><D><K><V><F><S><R><K><S><Y><L><E><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><R><H><D><S><H><L><A><Q><H><I><V><I><H><T><R><E><K><P><Y><K><C><N><E><C><G><K><T><F><G><E><N><S><A><L><L><V><H><K><T><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><N><Q><Q><S><N><L><A><R><H><H><R><L><H><T><G><E><K><P><Y><K><C><K><E><C><D><K><V><F><S><R><K><S><H><L><E><R><H><R><R><I><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><R><R><D><S><H><L><A><Q><H><T><V><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><T><F><V><Q><N><S><S><L><V><M><H><K><V><I><H><T><G><E><K><R><Y><K><C><N><E><C><G><K><S><F><N><H><K><S><S><L><A><Y><H><H><R><L><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><R><T><Q><S><Q><L><A><C><H><H><R><L><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><V><F><N><I><K><S><H><L><E><I><H><R><R><V><H><T><G><E><K><P><Y><K><C><R><V><C><D><K><A><F><G><R><D><S><Y><L><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><K><C><K><V><C><D><K><A><F><K><C><Y><S><H><L><A><Q><H><T><R><I><H><T><G><E><K><P><F><K><C><S><E><C><G><K><A><F><R><A><Q><S><T><L><I><H><H><Q><A><I><H><G><V><G><K><L><D>
May be involved in transcriptional regulation.<BOP>
P0CJ79
Q8N145
LGI3_HUMAN
Leucine-rich glioma-inactivated protein 3
Homo
<M><A><G><L><R><A><R><G><G><P><G><P><G><L><L><A><L><S><A><L><G><F><C><L><M><L><Q><V><S><A><K><R><P><P><K><T><P><P><C><P><P><S><C><S><C><T><R><D><T><A><F><C><V><D><S><K><A><V><P><R><N><L><P><S><E><V><I><S><L><T><L><V><N><A><A><F><S><E><I><Q><D><G><A><F><S><H><L><P><L><L><Q><F><L><L><L><N><S><N><K><F><T><L><I><G><D><N><A><F><T><G><L><S><H><L><Q><Y><L><F><I><E><N><N><D><I><W><A><L><S><K><F><T><F><R><G><L><K><S><L><T><H><L><S><L><A><N><N><N><L><Q><T><L><P><R><D><I><F><R><P><L><D><I><L><N><D><L><D><L><R><G><N><S><L><N><C><D><C><K><V><K><W><L><V><E><W><L><A><H><T><N><T><T><V><A><P><I><Y><C><A><S><P><P><R><F><Q><E><H><K><V><Q><D><L><P><L><R><E><F><D><C><I><T><T><D><F><V><L><Y><Q><T><L><A><F><P><A><V><S><A><E><P><F><L><Y><S><S><D><L><Y><L><A><L><A><Q><P><G><V><S><A><C><T><I><L><K><W><D><Y><V><E><R><Q><L><R><D><Y><D><R><I><P><A><P><S><A><V><H><C><K><P><M><V><V><D><S><Q><L><Y><V><V><V><A><Q><L><F><G><G><S><Y><I><Y><H><W><D><P><N><T><T><R><F><T><R><L><Q><D><I><D><P><Q><R><V><R><K><P><N><D><L><E><A><F><R><I><D><G><D><W><Y><F><A><V><A><D><S><S><K><A><G><A><T><S><L><Y><R><W><H><Q><N><G><F><Y><S><H><Q><A><L><H><P><W><H><R><D><T><D><L><E><F><V><D><G><E><G><K><P><R><L><I><V><S><S><S><S><Q><A><P><V><I><Y><Q><W><S><R><T><Q><K><Q><F><V><A><Q><G><E><V><T><Q><V><P><D><A><Q><A><V><K><H><F><R><A><G><R><D><S><Y><L><C><L><S><R><Y><I><G><D><S><K><I><L><R><W><E><G><T><R><F><S><E><V><Q><A><L><P><S><R><G><S><L><A><L><Q><P><F><L><V><G><G><R><R><Y><L><A><L><G><S><D><F><S><F><T><Q><I><Y><Q><W><D><E><G><R><Q><K><F><V><R><F><Q><E><L><A><V><Q><A><P><R><A><F><C><Y><M><P><A><G><D><A><Q><L><L><L><A><P><S><F><K><G><Q><T><L><V><Y><R><H><I><V><V><D><L><S><A>
May participate in the regulation of neuronal exocytosis.<BOP>
Q8N145
Q8NEZ5
FBX22_HUMAN
F-box protein FBX22p44
Homo
<M><E><P><V><G><C><C><G><E><C><R><G><S><S><V><D><P><R><S><T><F><V><L><S><N><L><A><E><V><V><E><R><V><L><T><F><L><P><A><K><A><L><L><R><V><A><C><V><C><R><L><W><R><E><C><V><R><R><V><L><R><T><H><R><S><V><T><W><I><S><A><G><L><A><E><A><G><H><L><E><G><H><C><L><V><R><V><V><A><E><E><L><E><N><V><R><I><L><P><H><T><V><L><Y><M><A><D><S><E><T><F><I><S><L><E><E><C><R><G><H><K><R><A><R><K><R><T><S><M><E><T><A><L><A><L><E><K><L><F><P><K><Q><C><Q><V><L><G><I><V><T><P><G><I><V><V><T><P><M><G><S><G><S><N><R><P><Q><E><I><E><I><G><E><S><G><F><A><L><L><F><P><Q><I><E><G><I><K><I><Q><P><F><H><F><I><K><D><P><K><N><L><T><L><E><R><H><Q><L><T><E><V><G><L><L><D><N><P><E><L><R><V><V><L><V><F><G><Y><N><C><C><K><V><G><A><S><N><Y><L><Q><Q><V><V><S><T><F><S><D><M><N><I><I><L><A><G><G><Q><V><D><N><L><S><S><L><T><S><E><K><N><P><L><D><I><D><A><S><G><V><V><G><L><S><F><S><G><H><R><I><Q><S><A><T><V><L><L><N><E><D><V><S><D><E><K><T><A><E><A><A><M><Q><R><L><K><A><A><N><I><P><E><H><N><T><I><G><F><M><F><A><C><V><G><R><G><F><Q><Y><Y><R><A><K><G><N><V><E><A><D><A><F><R><K><F><F><P><S><V><P><L><F><G><F><F><G><N><G><E><I><G><C><D><R><I><V><T><G><N><F><I><L><R><K><C><N><E><V><K><D><D><D><L><F><H><S><Y><T><T><I><M><A><L><I><H><L><G><S><S><K>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.<BOP>
Q8NEZ5
P20839
IMDH1_HUMAN
IMPDH-I
Homo
<M><A><D><Y><L><I><S><G><G><T><G><Y><V><P><E><D><G><L><T><A><Q><Q><L><F><A><S><A><D><G><L><T><Y><N><D><F><L><I><L><P><G><F><I><D><F><I><A><D><E><V><D><L><T><S><A><L><T><R><K><I><T><L><K><T><P><L><I><S><S><P><M><D><T><V><T><E><A><D><M><A><I><A><M><A><L><M><G><G><I><G><F><I><H><H><N><C><T><P><E><F><Q><A><N><E><V><R><K><V><K><K><F><E><Q><G><F><I><T><D><P><V><V><L><S><P><S><H><T><V><G><D><V><L><E><A><K><M><R><H><G><F><S><G><I><P><I><T><E><T><G><T><M><G><S><K><L><V><G><I><V><T><S><R><D><I><D><F><L><A><E><K><D><H><T><T><L><L><S><E><V><M><T><P><R><I><E><L><V><V><A><P><A><G><V><T><L><K><E><A><N><E><I><L><Q><R><S><K><K><G><K><L><P><I><V><N><D><C><D><E><L><V><A><I><I><A><R><T><D><L><K><K><N><R><D><Y><P><L><A><S><K><D><S><Q><K><Q><L><L><C><G><A><A><V><G><T><R><E><D><D><K><Y><R><L><D><L><L><T><Q><A><G><V><D><V><I><V><L><D><S><S><Q><G><N><S><V><Y><Q><I><A><M><V><H><Y><I><K><Q><K><Y><P><H><L><Q><V><I><G><G><N><V><V><T><A><A><Q><A><K><N><L><I><D><A><G><V><D><G><L><R><V><G><M><G><C><G><S><I><C><I><T><Q><E><V><M><A><C><G><R><P><Q><G><T><A><V><Y><K><V><A><E><Y><A><R><R><F><G><V><P><I><I><A><D><G><G><I><Q><T><V><G><H><V><V><K><A><L><A><L><G><A><S><T><V><M><M><G><S><L><L><A><A><T><T><E><A><P><G><E><Y><F><F><S><D><G><V><R><L><K><K><Y><R><G><M><G><S><L><D><A><M><E><K><S><S><S><S><Q><K><R><Y><F><S><E><G><D><K><V><K><I><A><Q><G><V><S><G><S><I><Q><D><K><G><S><I><Q><K><F><V><P><Y><L><I><A><G><I><Q><H><G><C><Q><D><I><G><A><R><S><L><S><V><L><R><S><M><M><Y><S><G><E><L><K><F><E><K><R><T><M><S><A><Q><I><E><G><G><V><H><G><L><H><S><Y><E><K><R><L><Y>
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.<BOP>
P20839
Q8WZ79
DNS2B_HUMAN
Endonuclease DLAD
Homo
<M><K><Q><K><M><M><A><R><L><L><R><T><S><F><A><L><L><F><L><G><L><F><G><V><L><G><A><A><T><I><S><C><R><N><E><E><G><K><A><V><D><W><F><T><F><Y><K><L><P><K><R><Q><N><K><E><S><G><E><T><G><L><E><Y><L><Y><L><D><S><T><T><R><S><W><R><K><S><E><Q><L><M><N><D><T><K><S><V><L><G><R><T><L><Q><Q><L><Y><E><A><Y><A><S><K><S><N><N><T><A><Y><L><I><Y><N><D><G><V><P><K><P><V><N><Y><S><R><K><Y><G><H><T><K><G><L><L><L><W><N><R><V><Q><G><F><W><L><I><H><S><I><P><Q><F><P><P><I><P><E><E><G><Y><D><Y><P><P><T><G><R><R><N><G><Q><S><G><I><C><I><T><F><K><Y><N><Q><Y><E><A><I><D><S><Q><L><L><V><C><N><P><N><V><Y><S><C><S><I><P><A><T><F><H><Q><E><L><I><H><M><P><Q><L><C><T><R><A><S><S><S><E><I><P><G><R><L><L><T><T><L><Q><S><A><Q><G><Q><K><F><L><H><F><A><K><S><D><S><F><L><D><D><I><F><A><A><W><M><A><Q><R><L><K><T><H><L><L><T><E><T><W><Q><R><K><R><Q><E><L><P><S><N><C><S><L><P><Y><H><V><Y><N><I><K><A><I><K><L><S><R><H><S><Y><F><S><S><Y><Q><D><H><A><K><W><C><I><S><Q><K><G><T><K><N><R><W><T><C><I><G><D><L><N><R><S><P><H><Q><A><F><R><S><G><G><F><I><C><T><Q><N><W><Q><I><Y><Q><A><F><Q><G><L><V><L><Y><Y><E><S><C><K>
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.<BOP>
Q8WZ79
O43837
IDH3B_HUMAN
NAD(+)-specific ICDH subunit beta
Homo
<M><A><A><L><S><G><V><R><W><L><T><R><A><L><V><S><A><G><N><P><G><A><W><R><G><L><S><T><S><A><A><A><H><A><A><S><R><S><Q><A><E><D><V><R><V><E><G><S><F><P><V><T><M><L><P><G><D><G><V><G><P><E><L><M><H><A><V><K><E><V><F><K><A><A><A><V><P><V><E><F><Q><E><H><H><L><S><E><V><Q><N><M><A><S><E><E><K><L><E><Q><V><L><S><S><M><K><E><N><K><V><A><I><I><G><K><I><H><T><P><M><E><Y><K><G><E><L><A><S><Y><D><M><R><L><R><R><K><L><D><L><F><A><N><V><V><H><V><K><S><L><P><G><Y><M><T><R><H><N><N><L><D><L><V><I><I><R><E><Q><T><E><G><E><Y><S><S><L><E><H><E><S><A><R><G><V><I><E><C><L><K><I><V><T><R><A><K><S><Q><R><I><A><K><F><A><F><D><Y><A><T><K><K><G><R><G><K><V><T><A><V><H><K><A><N><I><M><K><L><G><D><G><L><F><L><Q><C><C><E><E><V><A><E><L><Y><P><K><I><K><F><E><T><M><I><I><D><N><C><C><M><Q><L><V><Q><N><P><Y><Q><F><D><V><L><V><M><P><N><L><Y><G><N><I><I><D><N><L><A><A><G><L><V><G><G><A><G><V><V><P><G><E><S><Y><S><A><E><Y><A><V><F><E><T><G><A><R><H><P><F><A><Q><A><V><G><R><N><I><A><N><P><T><A><M><L><L><S><A><S><N><M><L><R><H><L><N><L><E><Y><H><S><S><M><I><A><D><A><V><K><K><V><I><K><V><G><K><V><R><T><R><D><M><G><G><Y><S><T><T><T><D><F><I><K><S><V><I><G><H><L><Q><T><K><G><S>
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.<BOP>
O43837
Q8NH89
O5AK3_HUMAN
Putative olfactory receptor 5AK3
Homo
<M><G><R><G><N><S><T><E><V><T><E><F><H><L><L><G><F><G><V><Q><H><E><F><Q><H><V><L><F><I><V><L><L><L><I><Y><V><T><S><L><I><G><N><I><G><M><I><L><L><I><K><T><D><S><R><L><Q><T><P><M><Y><F><F><P><Q><H><L><A><F><V><D><I><C><Y><T><S><A><I><T><P><K><M><L><Q><S><F><T><E><E><N><N><L><I><T><F><R><G><C><V><I><Q><F><L><V><Y><A><T><F><A><T><S><D><C><Y><L><L><A><I><M><A><M><D><C><Y><V><A><I><C><K><P><L><R><Y><P><M><I><M><S><Q><T><V><Y><I><Q><L><V><A><G><S><Y><I><I><G><S><I><N><A><S><V><H><T><G><F><T><F><S><L><S><F><C><K><S><N><K><I><N><H><F><F><C><D><G><L><P><I><L><A><L><S><C><S><N><I><D><I><N><I><I><L><D><V><V><F><V><G><F><D><L><M><F><T><E><L><V><I><I><F><S><Y><I><Y><I><M><V><T><I><L><K><M><S><S><T><A><G><R><K><K><S><F><S><T><C><A><S><H><L><T><A><V><T><I><F><Y><G><T><L><S><Y><M><Y><L><Q><P><Q><S><N><N><S><Q><E><N><M><K><V><A><S><I><F><Y><G><T><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><G><K>
Odorant receptor.<BOP>
Q8NH89
P84077
ARF1_HUMAN
ADP-ribosylation factor 1
Homo
<M><G><N><I><F><A><N><L><F><K><G><L><F><G><K><K><E><M><R><I><L><M><V><G><L><D><A><A><G><K><T><T><I><L><Y><K><L><K><L><G><E><I><V><T><T><I><P><T><I><G><F><N><V><E><T><V><E><Y><K><N><I><S><F><T><V><W><D><V><G><G><Q><D><K><I><R><P><L><W><R><H><Y><F><Q><N><T><Q><G><L><I><F><V><V><D><S><N><D><R><E><R><V><N><E><A><R><E><E><L><M><R><M><L><A><E><D><E><L><R><D><A><V><L><L><V><F><A><N><K><Q><D><L><P><N><A><M><N><A><A><E><I><T><D><K><L><G><L><H><S><L><R><H><R><N><W><Y><I><Q><A><T><C><A><T><S><G><D><G><L><Y><E><G><L><D><W><L><S><N><Q><L><R><N><Q><K>
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.<BOP>
P84077
P08620
FGF4_HUMAN
Transforming protein KS3
Homo
<M><S><G><P><G><T><A><A><V><A><L><L><P><A><V><L><L><A><L><L><A><P><W><A><G><R><G><G><A><A><A><P><T><A><P><N><G><T><L><E><A><E><L><E><R><R><W><E><S><L><V><A><L><S><L><A><R><L><P><V><A><A><Q><P><K><E><A><A><V><Q><S><G><A><G><D><Y><L><L><G><I><K><R><L><R><R><L><Y><C><N><V><G><I><G><F><H><L><Q><A><L><P><D><G><R><I><G><G><A><H><A><D><T><R><D><S><L><L><E><L><S><P><V><E><R><G><V><V><S><I><F><G><V><A><S><R><F><F><V><A><M><S><S><K><G><K><L><Y><G><S><P><F><F><T><D><E><C><T><F><K><E><I><L><L><P><N><N><Y><N><A><Y><E><S><Y><K><Y><P><G><M><F><I><A><L><S><K><N><G><K><T><K><K><G><N><R><V><S><P><T><M><K><V><T><H><F><L><P><R><L>
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.<BOP>
P08620
Q9NPI5
NRK2_HUMAN
Ribosylnicotinic acid kinase 2
Homo
<M><K><L><I><V><G><I><G><G><M><T><N><G><G><K><T><T><L><T><N><S><L><L><R><A><L><P><N><C><C><V><I><H><Q><D><D><F><F><K><P><Q><D><Q><I><A><V><G><E><D><G><F><K><Q><W><D><V><L><E><S><L><D><M><E><A><M><L><D><T><V><Q><A><W><L><S><S><P><Q><K><F><A><R><A><H><G><V><S><V><Q><P><E><A><S><D><T><H><I><L><L><L><E><G><F><L><L><Y><S><Y><K><P><L><V><D><L><Y><S><R><R><Y><F><L><T><V><P><Y><E><E><C><K><W><R><R><S><T><R><N><Y><T><V><P><D><P><P><G><L><F><D><G><H><V><W><P><M><Y><Q><K><Y><R><Q><E><M><E><A><N><G><V><E><V><V><Y><L><D><G><M><K><S><R><E><E><L><F><R><E><V><L><E><D><I><Q><N><S><L><L><N><R><S><Q><E><S><A><P><S><P><A><R><P><A><R><T><Q><G><P><G><R><G><C><G><H><R><T><A><R><P><A><A><S><Q><Q><D><S><M>
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.<BOP>
Q9NPI5
Q9BYQ6
KR411_HUMAN
Ultrahigh sulfur keratin-associated protein 4.14
Homo
<M><V><N><S><C><C><G><S><V><C><S><H><Q><G><C><G><R><D><L><C><Q><E><T><C><C><R><P><S><C><C><E><T><T><C><C><R><T><T><Y><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><R><C><C><I><S><S><C><C><R><P><S><C><C><V><S><S><C><C><K><P><Q><C><C><Q><S><M><C><C><Q><P><T><C><C><R><P><R><C><C><I><S><S><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><H><P><S><C><S><I><S><S><C><C><R><P><S><C><C><E><S><S><C><C><R><P><C><C><C><L><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><T><C><V><I><S><S><C><P><R><P><L><C><C><A><S><S><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BYQ6
Q8IXA5
SACA3_HUMAN
Sperm acrosome membrane-associated protein 3, processed form
Homo
<M><V><S><A><L><R><G><A><P><L><I><R><V><H><S><S><P><V><S><S><P><S><V><S><G><P><R><R><L><V><S><C><L><S><S><Q><S><S><A><L><S><Q><S><G><G><G><S><T><S><A><A><G><I><E><A><R><S><R><A><L><R><R><R><W><C><P><A><G><I><M><L><L><A><L><V><C><L><L><S><C><L><L><P><S><S><E><A><K><L><Y><G><R><C><E><L><A><R><V><L><H><D><F><G><L><D><G><Y><R><G><Y><S><L><A><D><W><V><C><L><A><Y><F><T><S><G><F><N><A><A><A><L><D><Y><E><A><D><G><S><T><N><N><G><I><F><Q><I><N><S><R><R><W><C><S><N><L><T><P><N><V><P><N><V><C><R><M><Y><C><S><D><L><L><N><P><N><L><K><D><T><V><I><C><A><M><K><I><T><Q><E><P><Q><G><L><G><Y><W><E><A><W><R><H><H><C><Q><G><K><D><L><T><E><W><V><D><G><C><D><F>
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.<BOP>
Q8IXA5
P07339
CATD_HUMAN
Cathepsin D heavy chain
Homo
<M><Q><P><S><S><L><L><P><L><A><L><C><L><L><A><A><P><A><S><A><L><V><R><I><P><L><H><K><F><T><S><I><R><R><T><M><S><E><V><G><G><S><V><E><D><L><I><A><K><G><P><V><S><K><Y><S><Q><A><V><P><A><V><T><E><G><P><I><P><E><V><L><K><N><Y><M><D><A><Q><Y><Y><G><E><I><G><I><G><T><P><P><Q><C><F><T><V><V><F><D><T><G><S><S><N><L><W><V><P><S><I><H><C><K><L><L><D><I><A><C><W><I><H><H><K><Y><N><S><D><K><S><S><T><Y><V><K><N><G><T><S><F><D><I><H><Y><G><S><G><S><L><S><G><Y><L><S><Q><D><T><V><S><V><P><C><Q><S><A><S><S><A><S><A><L><G><G><V><K><V><E><R><Q><V><F><G><E><A><T><K><Q><P><G><I><T><F><I><A><A><K><F><D><G><I><L><G><M><A><Y><P><R><I><S><V><N><N><V><L><P><V><F><D><N><L><M><Q><Q><K><L><V><D><Q><N><I><F><S><F><Y><L><S><R><D><P><D><A><Q><P><G><G><E><L><M><L><G><G><T><D><S><K><Y><Y><K><G><S><L><S><Y><L><N><V><T><R><K><A><Y><W><Q><V><H><L><D><Q><V><E><V><A><S><G><L><T><L><C><K><E><G><C><E><A><I><V><D><T><G><T><S><L><M><V><G><P><V><D><E><V><R><E><L><Q><K><A><I><G><A><V><P><L><I><Q><G><E><Y><M><I><P><C><E><K><V><S><T><L><P><A><I><T><L><K><L><G><G><K><G><Y><K><L><S><P><E><D><Y><T><L><K><V><S><Q><A><G><K><T><L><C><L><S><G><F><M><G><M><D><I><P><P><P><S><G><P><L><W><I><L><G><D><V><F><I><G><R><Y><Y><T><V><F><D><R><D><N><N><R><V><G><F><A><E><A><A><R><L>
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation . Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.<BOP>
P07339
Q9H2C1
LHX5_HUMAN
LIM/homeobox protein Lhx5
Homo
<M><M><V><H><C><A><G><C><E><R><P><I><L><D><R><F><L><L><N><V><L><D><R><A><W><H><I><K><C><V><Q><C><C><E><C><K><T><N><L><S><E><K><C><F><S><R><E><G><K><L><Y><C><K><N><D><F><F><R><R><F><G><T><K><C><A><G><C><A><Q><G><I><S><P><S><D><L><V><R><K><A><R><S><K><V><F><H><L><N><C><F><T><C><M><V><C><N><K><Q><L><S><T><G><E><E><L><Y><V><I><D><E><N><K><F><V><C><K><D><D><Y><L><S><S><S><S><L><K><E><G><S><L><N><S><V><S><S><C><T><D><R><S><L><S><P><D><L><Q><D><A><L><Q><D><D><P><K><E><T><D><N><S><T><S><S><D><K><E><T><A><N><N><E><N><E><E><Q><N><S><G><T><K><R><R><G><P><R><T><T><I><K><A><K><Q><L><E><T><L><K><A><A><F><A><A><T><P><K><P><T><R><H><I><R><E><Q><L><A><Q><E><T><G><L><N><M><R><V><I><Q><V><W><F><Q><N><R><R><S><K><E><R><R><M><K><Q><L><S><A><L><G><A><R><R><H><A><F><F><R><S><P><R><R><M><R><P><L><G><G><R><L><D><E><S><E><M><L><G><S><T><P><Y><T><Y><Y><G><D><Y><Q><G><D><Y><Y><A><P><G><S><N><Y><D><F><F><A><H><G><P><P><S><Q><A><Q><S><P><A><D><S><S><F><L><A><A><S><G><P><G><S><T><P><L><G><A><L><E><P><P><L><A><G><P><H><A><A><D><N><P><R><F><T><D><M><I><S><H><P><D><T><P><S><P><E><P><G><L><P><G><T><L><H><P><M><P><G><E><V><F><S><G><G><P><S><P><P><F><P><M><S><G><T><S><G><Y><S><G><P><L><S><H><P><N><P><E><L><N><E><A><A><V><W>
Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.<BOP>
Q9H2C1
P33763
S10A5_HUMAN
S100 calcium-binding protein A5
Homo
<M><E><T><P><L><E><K><A><L><T><T><M><V><T><T><F><H><K><Y><S><G><R><E><G><S><K><L><T><L><S><R><K><E><L><K><E><L><I><K><K><E><L><C><L><G><E><M><K><E><S><S><I><D><D><L><M><K><S><L><D><K><N><S><D><Q><E><I><D><F><K><E><Y><S><V><F><L><T><M><L><C><M><A><Y><N><D><F><F><L><E><D><N><K>
Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.<BOP>
P33763
Q6ZN18
AEBP2_HUMAN
Adipocyte enhancer-binding protein 2
Homo
<M><A><A><A><I><T><D><M><A><D><L><E><E><L><S><R><L><S><P><L><P><P><G><S><P><G><S><A><A><R><G><R><A><E><P><P><E><E><E><E><E><E><E><E><E><E><E><E><A><E><A><E><A><V><A><A><L><L><L><N><G><G><S><G><G><G><G><G><G><G><G><G><G><V><G><G><G><E><A><E><T><M><S><E><P><S><P><E><S><A><S><Q><A><G><E><D><E><D><E><E><E><D><D><E><E><E><E><D><E><S><S><S><S><G><G><G><E><E><E><S><S><A><E><S><L><V><G><S><S><G><G><S><S><S><D><E><T><R><S><L><S><P><G><A><A><S><S><S><S><G><D><G><D><G><K><E><G><L><E><E><P><K><G><P><R><G><S><Q><G><G><G><G><G><G><S><S><S><S><S><V><V><S><S><G><G><D><E><G><Y><G><T><G><G><G><G><S><S><A><T><S><G><G><R><R><G><S><L><E><M><S><S><D><G><E><P><L><S><R><M><D><S><E><D><S><I><S><S><T><I><M><D><V><D><S><T><I><S><S><G><R><S><T><P><A><M><M><N><G><Q><G><S><T><T><S><S><S><K><N><I><A><Y><N><C><C><W><D><Q><C><Q><A><C><F><N><S><S><P><D><L><A><D><H><I><R><S><I><H><V><D><G><Q><R><G><G><V><F><V><C><L><W><K><G><C><K><V><Y><N><T><P><S><T><S><Q><S><W><L><Q><R><H><M><L><T><H><S><G><D><K><P><F><K><C><V><V><G><G><C><N><A><S><F><A><S><Q><G><G><L><A><R><H><V><P><T><H><F><S><Q><Q><N><S><S><K><V><S><S><Q><P><K><A><K><E><E><S><P><S><K><A><G><M><N><K><R><R><K><L><K><N><K><R><R><R><S><L><P><R><P><H><D><F><F><D><A><Q><T><L><D><A><I><R><H><R><A><I><C><F><N><L><S><A><H><I><E><S><L><G><K><G><H><S><V><V><F><H><S><T><V><I><A><K><R><K><E><D><S><G><K><I><K><L><L><L><H><W><M><P><E><D><I><L><P><D><V><W><V><N><E><S><E><R><H><Q><L><K><T><K><V><V><H><L><S><K><L><P><K><D><T><A><L><L><L><D><P><N><I><Y><R><T><M><P><Q><K><R><L><K><R><T><L><I><R><K><V><F><N><L><Y><L><S><K><Q>
Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene . Plays a role in nucleosome localization of the PRC2 complex .<BOP>
Q6ZN18
Q8IWZ8
SUGP1_HUMAN
Splicing factor 4
Homo
<M><S><L><K><M><D><N><R><D><V><A><G><K><A><N><R><W><F><G><V><A><P><P><K><S><G><K><M><N><M><N><I><L><H><Q><E><E><L><I><A><Q><K><K><R><E><I><E><A><K><M><E><Q><K><A><K><Q><N><Q><V><A><S><P><Q><P><P><H><P><G><E><I><T><N><A><H><N><S><S><C><I><S><N><K><F><A><N><D><G><S><F><L><Q><Q><F><L><K><L><Q><K><A><Q><T><S><T><D><A><P><T><S><A><P><S><A><P><P><S><T><P><T><P><S><A><G><K><R><S><L><L><I><S><R><R><T><G><L><G><L><A><S><L><P><G><P><V><K><S><Y><S><H><A><K><Q><L><P><V><A><H><R><P><S><V><F><Q><S><P><D><E><D><E><E><E><D><Y><E><Q><W><L><E><I><K><V><S><P><P><E><G><A><E><T><R><K><V><I><E><K><L><A><R><F><V><A><E><G><G><P><E><L><E><K><V><A><M><E><D><Y><K><D><N><P><A><F><A><F><L><H><D><K><N><S><R><E><F><L><Y><Y><R><K><K><V><A><E><I><R><K><E><A><Q><K><S><Q><A><A><S><Q><K><V><S><P><P><E><D><E><E><V><K><N><L><A><E><K><L><A><R><F><I><A><D><G><G><P><E><V><E><T><I><A><L><Q><N><N><R><E><N><Q><A><F><S><F><L><Y><E><P><N><S><Q><G><Y><K><Y><Y><R><Q><K><L><E><E><F><R><K><A><K><A><S><S><T><G><S><F><T><A><P><D><P><G><L><K><R><K><S><P><P><E><A><L><S><G><S><L><P><P><A><T><T><C><P><A><S><S><T><P><A><P><T><I><I><P><A><P><A><A><P><G><K><P><A><S><A><A><T><V><K><R><K><R><K><S><R><W><G><P><E><E><D><K><V><E><L><P><P><A><E><L><V><Q><R><D><V><D><A><S><P><S><P><L><S><V><Q><D><L><K><G><L><G><Y><E><K><G><K><P><V><G><L><V><G><V><T><E><L><S><D><A><Q><K><K><Q><L><K><E><Q><Q><E><M><Q><Q><M><Y><D><M><I><M><Q><H><K><R><A><M><Q><D><M><Q><L><L><W><E><K><A><V><Q><Q><H><Q><H><G><Y><D><S><D><E><E><V><D><S><E><L><G><T><W><E><H><Q><L><R><R><M><E><M><D><K><T><R><E><W><A><E><Q><L><T><K><M><G><R><G><K><H><F><I><G><D><F><L><P><P><D><E><L><E><K><F><M><E><T><F><K><A><L><K><E><G><R><E><P><D><Y><S><E><Y><K><E><F><K><L><T><V><E><N><I><G><Y><Q><M><L><M><K><M><G><W><K><E><G><E><G><L><G><S><E><G><Q><G><I><K><N><P><V><N><K><G><T><T><T><V><D><G><A><G><F><G><I><D><R><P><A><E><L><S><K><E><D><D><E><Y><E><A><F><R><K><R><M><M><L><A><Y><R><F><R><P><N><P><L><N><N><P><R><R><P><Y><Y>
Plays a role in pre-mRNA splicing.<BOP>
Q8IWZ8
O95279
KCNK5_HUMAN
TWIK-related acid-sensitive K(+) channel 2
Homo
<M><V><D><R><G><P><L><L><T><S><A><I><I><F><Y><L><A><I><G><A><A><I><F><E><V><L><E><E><P><H><W><K><E><A><K><K><N><Y><Y><T><Q><K><L><H><L><L><K><E><F><P><C><L><G><Q><E><G><L><D><K><I><L><E><V><V><S><D><A><A><G><Q><G><V><A><I><T><G><N><Q><T><F><N><N><W><N><W><P><N><A><M><I><F><A><A><T><V><I><T><T><I><G><Y><G><N><V><A><P><K><T><P><A><G><R><L><F><C><V><F><Y><G><L><F><G><V><P><L><C><L><T><W><I><S><A><L><G><K><F><F><G><G><R><A><K><R><L><G><Q><F><L><T><K><R><G><V><S><L><R><K><A><Q><I><T><C><T><V><I><F><I><V><W><G><V><L><V><H><L><V><I><P><P><F><V><F><M><V><T><E><G><W><N><Y><I><E><G><L><Y><Y><S><F><I><T><I><S><T><I><G><F><G><D><F><V><A><G><V><N><P><S><A><N><Y><H><A><L><Y><R><Y><F><V><E><L><W><I><Y><L><G><L><A><W><L><S><L><F><V><N><W><K><V><S><M><F><V><E><V><H><K><A><I><K><K><R><R><R><R><R><K><E><S><F><E><S><S><P><H><S><R><K><A><L><Q><V><K><G><S><T><A><S><K><D><V><N><I><F><S><F><L><S><K><K><E><E><T><Y><N><D><L><I><K><Q><I><G><K><K><A><M><K><T><S><G><G><G><E><T><G><P><G><P><G><L><G><P><Q><G><G><G><L><P><A><L><P><P><S><L><V><P><L><V><V><Y><S><K><N><R><V><P><T><L><E><E><V><S><Q><T><L><R><S><K><G><H><V><S><R><S><P><D><E><E><A><V><A><R><A><P><E><D><S><S><P><A><P><E><V><F><M><N><Q><L><D><R><I><S><E><E><C><E><P><W><D><A><Q><D><Y><H><P><L><I><F><Q><D><A><S><I><T><F><V><N><T><E><A><G><L><S><D><E><E><T><S><K><S><S><L><E><D><N><L><A><G><E><E><S><P><Q><Q><G><A><E><A><K><A><P><L><N><M><G><E><F><P><S><S><S><E><S><T><F><T><S><T><E><S><E><L><S><V><P><Y><E><Q><L><M><N><E><Y><N><K><A><N><S><P><K><G><T>
pH-dependent, outwardly rectifying potassium channel . Outward rectification is lost at high external K(+) concentrations .<BOP>
O95279
Q8N6Q8
MET25_HUMAN
Probable methyltransferase-like protein 25
Homo
<M><A><A><S><C><P><L><P><V><T><P><D><L><P><T><L><R><A><K><L><Q><G><L><L><Q><F><L><R><D><A><L><S><I><S><N><A><H><T><V><D><F><Y><T><E><S><V><W><E><E><L><V><D><L><P><P><E><T><V><L><A><A><L><R><K><S><A><S><E><T><E><A><L><P><S><E><T><R><P><L><V><E><A><E><W><E><A><G><M><T><D><F><P><K><I><F><C><E><T><S><Q><K><L><V><S><V><E><A><F><A><L><A><A><K><Y><Y><S><V><Q><N><L><G><I><C><T><P><F><E><Q><L><L><V><A><L><R><G><N><Q><N><Q><R><I><G><E><N><Q><K><A><V><E><F><M><N><M><K><K><S><H><E><V><Q><A><M><S><E><L><I><S><S><I><A><D><Y><Y><G><I><K><Q><V><I><D><L><G><S><G><K><G><Y><L><S><S><F><L><S><L><K><Y><G><L><K><V><Y><G><I><D><S><S><N><T><N><T><H><G><A><E><E><R><N><R><K><L><K><K><H><W><K><L><C><H><A><Q><S><R><L><D><V><N><G><L><A><L><K><M><A><K><E><R><K><V><Q><N><K><V><K><N><K><A><D><T><E><E><V><F><N><N><S><P><T><N><Q><E><K><M><P><T><S><A><I><L><P><D><F><S><G><S><V><I><S><N><I><R><N><Q><M><E><T><L><H><S><Q><P><H><Q><E><E><N><L><C><F><E><N><S><F><S><L><I><N><L><L><P><I><N><A><V><E><P><T><S><S><Q><Q><I><P><N><R><E><T><S><E><A><N><K><E><R><R><K><M><T><S><K><S><S><E><S><N><I><Y><S><P><L><T><S><F><I><T><A><D><S><E><L><H><D><I><I><K><D><L><E><D><C><L><M><V><G><L><H><T><C><G><D><L><A><P><N><T><L><R><I><F><T><S><N><S><E><I><K><G><V><C><S><V><G><C><C><Y><H><L><L><S><E><E><F><E><N><Q><H><K><E><R><T><Q><E><K><W><G><F><P><M><C><H><Y><L><K><E><E><R><W><C><C><G><R><N><A><R><M><S><A><C><L><A><L><E><R><V><A><A><G><Q><G><L><P><T><E><S><L><F><Y><R><A><V><L><Q><D><I><I><K><D><C><Y><G><I><T><K><C><D><R><H><V><G><K><I><Y><S><K><C><S><S><F><L><D><Y><V><R><R><S><L><K><K><L><G><L><D><E><S><K><L><P><E><K><I><I><M><N><Y><Y><E><K><Y><K><P><R><M><N><E><L><E><A><F><N><M><L><K><V><V><L><A><P><C><I><E><T><L><I><L><L><D><R><L><C><Y><L><K><E><Q><E><D><I><A><W><S><A><L><V><K><L><F><D><P><V><K><S><P><R><C><Y><A><V><I><A><L><K><K><Q><Q>
Probable methyltransferase.<BOP>
Q8N6Q8
Q6UW68
TM205_HUMAN
Transmembrane protein 205
Homo
<M><E><E><G><G><N><L><G><G><L><I><K><M><V><H><L><L><V><L><S><G><A><W><G><M><Q><M><W><V><T><F><V><S><G><F><L><L><F><R><S><L><P><R><H><T><F><G><L><V><Q><S><K><L><F><P><F><Y><F><H><I><S><M><G><C><A><F><I><N><L><C><I><L><A><S><Q><H><A><W><A><Q><L><T><F><W><E><A><S><Q><L><Y><L><L><F><L><S><L><T><L><A><T><V><N><A><R><W><L><E><P><R><T><T><A><A><M><W><A><L><Q><T><V><E><K><E><R><G><L><G><G><E><V><P><G><S><H><Q><G><P><D><P><Y><R><Q><L><R><E><K><D><P><K><Y><S><A><L><R><Q><N><F><F><R><Y><H><G><L><S><S><L><C><N><L><G><C><V><L><S><N><G><L><C><L><A><G><L><A><L><E><I><R><S><L>
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.<BOP>
Q6UW68
Q9UM63
PLAL1_HUMAN
Tumor suppressor ZAC
Homo
<M><A><T><F><P><C><Q><L><C><G><K><T><F><L><T><L><E><K><F><T><I><H><N><Y><S><H><S><R><E><R><P><Y><K><C><V><Q><P><D><C><G><K><A><F><V><S><R><Y><K><L><M><R><H><M><A><T><H><S><P><Q><K><S><H><Q><C><A><H><C><E><K><T><F><N><R><K><D><H><L><K><N><H><L><Q><T><H><D><P><N><K><M><A><F><G><C><E><E><C><G><K><K><Y><N><T><M><L><G><Y><K><R><H><L><A><L><H><A><A><S><S><G><D><L><T><C><G><V><C><A><L><E><L><G><S><T><E><V><L><L><D><H><L><K><A><H><A><E><E><K><P><P><S><G><T><K><E><K><K><H><Q><C><D><H><C><E><R><C><F><Y><T><R><K><D><V><R><R><H><L><V><V><H><T><G><C><K><D><F><L><C><Q><F><C><A><Q><R><F><G><R><K><D><H><L><T><R><H><T><K><K><T><H><S><Q><E><L><M><K><E><S><L><Q><T><G><D><L><L><S><T><F><H><T><I><S><P><S><F><Q><L><K><A><A><A><L><P><P><F><P><L><G><A><S><A><Q><N><G><L><A><S><S><L><P><A><E><V><H><S><L><T><L><S><P><P><E><Q><A><A><Q><P><M><Q><P><L><P><E><S><L><A><S><L><H><P><S><V><S><P><G><S><P><P><P><P><L><P><N><H><K><Y><N><T><T><S><T><S><Y><S><P><L><A><S><L><P><L><K><A><D><T><K><G><F><C><N><I><S><L><F><E><D><L><P><L><Q><E><P><Q><S><P><Q><K><L><N><P><G><F><D><L><A><K><G><N><A><G><K><V><N><L><P><K><E><L><P><A><D><A><V><N><L><T><I><P><A><S><L><D><L><S><P><L><L><G><F><W><Q><L><P><P><P><A><T><Q><N><T><F><G><N><S><T><L><A><L><G><P><G><E><S><L><P><H><R><L><S><C><L><G><Q><Q><Q><Q><E><P><P><L><A><M><G><T><V><S><L><G><Q><L><P><L><P><P><I><P><H><V><F><S><A><G><T><G><S><A><I><L><P><H><F><H><H><A><F><R>
Acts as a transcriptional activator . Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.<BOP>
Q9UM63
Q6P5S7
RNK_HUMAN
V-type proton ATPase subunit f
Homo
<M><G><W><L><R><P><G><P><R><P><L><C><P><P><A><R><A><S><W><A><F><S><H><R><F><P><S><P><L><A><P><R><R><S><P><T><P><F><F><M><A><S><L><L><C><C><G><P><K><L><A><A><C><G><I><V><L><S><A><W><G><V><I><M><L><I><M><L><G><I><F><F><N><V><H><S><A><V><L><I><E><D><V><P><F><T><E><K><D><F><E><N><G><P><Q><N><I><Y><N><L><Y><E><Q><V><S><Y><N><C><F><I><A><A><G><L><Y><L><L><L><G><G><F><S><F><C><Q><V><R><L><N><K><R><K><E><Y><M><V><R>
(Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses .<BOP>
Q6P5S7
P29401
TKT_HUMAN
Transketolase
Homo
<M><E><S><Y><H><K><P><D><Q><Q><K><L><Q><A><L><K><D><T><A><N><R><L><R><I><S><S><I><Q><A><T><T><A><A><G><S><G><H><P><T><S><C><C><S><A><A><E><I><M><A><V><L><F><F><H><T><M><R><Y><K><S><Q><D><P><R><N><P><H><N><D><R><F><V><L><S><K><G><H><A><A><P><I><L><Y><A><V><W><A><E><A><G><F><L><A><E><A><E><L><L><N><L><R><K><I><S><S><D><L><D><G><H><P><V><P><K><Q><A><F><T><D><V><A><T><G><S><L><G><Q><G><L><G><A><A><C><G><M><A><Y><T><G><K><Y><F><D><K><A><S><Y><R><V><Y><C><L><L><G><D><G><E><L><S><E><G><S><V><W><E><A><M><A><F><A><S><I><Y><K><L><D><N><L><V><A><I><L><D><I><N><R><L><G><Q><S><D><P><A><P><L><Q><H><Q><M><D><I><Y><Q><K><R><C><E><A><F><G><W><H><A><I><I><V><D><G><H><S><V><E><E><L><C><K><A><F><G><Q><A><K><H><Q><P><T><A><I><I><A><K><T><F><K><G><R><G><I><T><G><V><E><D><K><E><S><W><H><G><K><P><L><P><K><N><M><A><E><Q><I><I><Q><E><I><Y><S><Q><I><Q><S><K><K><K><I><L><A><T><P><P><Q><E><D><A><P><S><V><D><I><A><N><I><R><M><P><S><L><P><S><Y><K><V><G><D><K><I><A><T><R><K><A><Y><G><Q><A><L><A><K><L><G><H><A><S><D><R><I><I><A><L><D><G><D><T><K><N><S><T><F><S><E><I><F><K><K><E><H><P><D><R><F><I><E><C><Y><I><A><E><Q><N><M><V><S><I><A><V><G><C><A><T><R><N><R><T><V><P><F><C><S><T><F><A><A><F><F><T><R><A><F><D><Q><I><R><M><A><A><I><S><E><S><N><I><N><L><C><G><S><H><C><G><V><S><I><G><E><D><G><P><S><Q><M><A><L><E><D><L><A><M><F><R><S><V><P><T><S><T><V><F><Y><P><S><D><G><V><A><T><E><K><A><V><E><L><A><A><N><T><K><G><I><C><F><I><R><T><S><R><P><E><N><A><I><I><Y><N><N><N><E><D><F><Q><V><G><Q><A><K><V><V><L><K><S><K><D><D><Q><V><T><V><I><G><A><G><V><T><L><H><E><A><L><A><A><A><E><L><L><K><K><E><K><I><N><I><R><V><L><D><P><F><T><I><K><P><L><D><R><K><L><I><L><D><S><A><R><A><T><K><G><R><I><L><T><V><E><D><H><Y><Y><E><G><G><I><G><E><A><V><S><S><A><V><V><G><E><P><G><I><T><V><T><H><L><A><V><N><R><V><P><R><S><G><K><P><A><E><L><L><K><M><F><G><I><D><R><D><A><I><A><Q><A><V><R><G><L><I><T><K><A>
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.<BOP>
P29401
A0A075B767
PAL4H_HUMAN
Peptidyl-prolyl cis-trans isomerase A-like 4H
Homo
<M><V><N><S><V><V><F><F><D><I><T><V><D><G><K><P><L><G><R><I><S><I><K><L><F><A><D><K><I><P><K><T><A><E><N><F><R><A><L><S><T><G><E><K><G><F><R><Y><K><G><S><C><F><H><R><I><I><P><G><F><M><C><Q><G><G><D><F><T><R><P><N><G><T><D><D><K><S><I><Y><G><E><K><F><D><D><E><N><L><I><R><K><H><T><G><S><G><I><L><S><M><V><N><A><G><P><N><T><N><G><S><Q><L><F><I><C><T><A><K><T><E><W><L><D><G><K><H><V><A><F><G><K><V><K><E><R><V><N><I><V><E><A><M><E><H><F><G><Y><R><N><S><K><T><S><K><K><I><T><I><A><D><C><G><Q><F>
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<BOP>
A0A075B767
P07316
CRGB_HUMAN
Gamma-crystallin 1-2
Homo
<M><G><K><I><T><F><Y><E><D><R><A><F><Q><G><R><S><Y><E><C><T><T><D><C><P><N><L><Q><P><Y><F><S><R><C><N><S><I><R><V><E><S><G><C><W><M><I><Y><E><R><P><N><Y><Q><G><H><Q><Y><F><L><R><R><G><E><Y><P><D><Y><Q><Q><W><M><G><L><S><D><S><I><R><S><C><C><L><I><P><P><H><S><G><A><Y><R><M><K><I><Y><D><R><D><E><L><R><G><Q><M><S><E><L><T><D><D><C><I><S><V><Q><D><R><F><H><L><T><E><I><H><S><L><N><V><L><E><G><S><W><I><L><Y><E><M><P><N><Y><R><G><R><Q><Y><L><L><R><P><G><E><Y><R><R><F><L><D><W><G><A><P><N><A><K><V><G><S><L><R><R><V><M><D><L><Y>
Crystallins are the dominant structural components of the vertebrate eye lens.<BOP>
P07316
Q13496
MTM1_HUMAN
Phosphatidylinositol-3-phosphate phosphatase
Homo
<M><A><S><A><S><T><S><K><Y><N><S><H><S><L><E><N><E><S><I><K><R><T><S><R><D><G><V><N><R><D><L><T><E><A><V><P><R><L><P><G><E><T><L><I><T><D><K><E><V><I><Y><I><C><P><F><N><G><P><I><K><G><R><V><Y><I><T><N><Y><R><L><Y><L><R><S><L><E><T><D><S><S><L><I><L><D><V><P><L><G><V><I><S><R><I><E><K><M><G><G><A><T><S><R><G><E><N><S><Y><G><L><D><I><T><C><K><D><M><R><N><L><R><F><A><L><K><Q><E><G><H><S><R><R><D><M><F><E><I><L><T><R><Y><A><F><P><L><A><H><S><L><P><L><F><A><F><L><N><E><E><K><F><N><V><D><G><W><T><V><Y><N><P><V><E><E><Y><R><R><Q><G><L><P><N><H><H><W><R><I><T><F><I><N><K><C><Y><E><L><C><D><T><Y><P><A><L><L><V><V><P><Y><R><A><S><D><D><D><L><R><R><V><A><T><F><R><S><R><N><R><I><P><V><L><S><W><I><H><P><E><N><K><T><V><I><V><R><C><S><Q><P><L><V><G><M><S><G><K><R><N><K><D><D><E><K><Y><L><D><V><I><R><E><T><N><K><Q><I><S><K><L><T><I><Y><D><A><R><P><S><V><N><A><V><A><N><K><A><T><G><G><G><Y><E><S><D><D><A><Y><H><N><A><E><L><F><F><L><D><I><H><N><I><H><V><M><R><E><S><L><K><K><V><K><D><I><V><Y><P><N><V><E><E><S><H><W><L><S><S><L><E><S><T><H><W><L><E><H><I><K><L><V><L><T><G><A><I><Q><V><A><D><K><V><S><S><G><K><S><S><V><L><V><H><C><S><D><G><W><D><R><T><A><Q><L><T><S><L><A><M><L><M><L><D><S><F><Y><R><S><I><E><G><F><E><I><L><V><Q><K><E><W><I><S><F><G><H><K><F><A><S><R><I><G><H><G><D><K><N><H><T><D><A><D><R><S><P><I><F><L><Q><F><I><D><C><V><W><Q><M><S><K><Q><F><P><T><A><F><E><F><N><E><Q><F><L><I><I><I><L><D><H><L><Y><S><C><R><F><G><T><F><L><F><N><C><E><S><A><R><E><R><Q><K><V><T><E><R><T><V><S><L><W><S><L><I><N><S><N><K><E><K><F><K><N><P><F><Y><T><K><E><I><N><R><V><L><Y><P><V><A><S><M><R><H><L><E><L><W><V><N><Y><Y><I><R><W><N><P><R><I><K><Q><Q><Q><P><N><P><V><E><Q><R><Y><M><E><L><L><A><L><R><D><E><Y><I><K><R><L><E><E><L><Q><L><A><N><S><A><K><L><S><D><P><P><T><S><P><S><S><P><S><Q><M><M><P><H><V><Q><T><H><F>
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides . Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture . Plays a role in mitochondrial morphology and positioning . Required for skeletal muscle maintenance but not for myogenesis . In skeletal muscles, stabilizes MTMR12 protein levels .<BOP>
Q13496
P54819
KAD2_HUMAN
Adenylate kinase 2, mitochondrial, N-terminally processed
Homo
<M><A><P><S><V><P><A><A><E><P><E><Y><P><K><G><I><R><A><V><L><L><G><P><P><G><A><G><K><G><T><Q><A><P><R><L><A><E><N><F><C><V><C><H><L><A><T><G><D><M><L><R><A><M><V><A><S><G><S><E><L><G><K><K><L><K><A><T><M><D><A><G><K><L><V><S><D><E><M><V><V><E><L><I><E><K><N><L><E><T><P><L><C><K><N><G><F><L><L><D><G><F><P><R><T><V><R><Q><A><E><M><L><D><D><L><M><E><K><R><K><E><K><L><D><S><V><I><E><F><S><I><P><D><S><L><L><I><R><R><I><T><G><R><L><I><H><P><K><S><G><R><S><Y><H><E><E><F><N><P><P><K><E><P><M><K><D><D><I><T><G><E><P><L><I><R><R><S><D><D><N><E><K><A><L><K><I><R><L><Q><A><Y><H><T><Q><T><T><P><L><I><E><Y><Y><R><K><R><G><I><H><S><A><I><D><A><S><Q><T><P><D><V><V><F><A><S><I><L><A><A><F><S><K><A><T><C><K><D><L><V><M><F><I>
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.<BOP>
P54819
P26439
3BHS2_HUMAN
Delta-5-3-ketosteroid isomerase
Homo
<M><G><W><S><C><L><V><T><G><A><G><G><L><L><G><Q><R><I><V><R><L><L><V><E><E><K><E><L><K><E><I><R><A><L><D><K><A><F><R><P><E><L><R><E><E><F><S><K><L><Q><N><R><T><K><L><T><V><L><E><G><D><I><L><D><E><P><F><L><K><R><A><C><Q><D><V><S><V><V><I><H><T><A><C><I><I><D><V><F><G><V><T><H><R><E><S><I><M><N><V><N><V><K><G><T><Q><L><L><L><E><A><C><V><Q><A><S><V><P><V><F><I><Y><T><S><S><I><E><V><A><G><P><N><S><Y><K><E><I><I><Q><N><G><H><E><E><E><P><L><E><N><T><W><P><T><P><Y><P><Y><S><K><K><L><A><E><K><A><V><L><A><A><N><G><W><N><L><K><N><G><D><T><L><Y><T><C><A><L><R><P><T><Y><I><Y><G><E><G><G><P><F><L><S><A><S><I><N><E><A><L><N><N><N><G><I><L><S><S><V><G><K><F><S><T><V><N><P><V><Y><V><G><N><V><A><W><A><H><I><L><A><L><R><A><L><R><D><P><K><K><A><P><S><V><R><G><Q><F><Y><Y><I><S><D><D><T><P><H><Q><S><Y><D><N><L><N><Y><I><L><S><K><E><F><G><L><R><L><D><S><R><W><S><L><P><L><T><L><M><Y><W><I><G><F><L><L><E><V><V><S><F><L><L><S><P><I><Y><S><Y><Q><P><P><F><N><R><H><T><V><T><L><S><N><S><V><F><T><F><S><Y><K><K><A><Q><R><D><L><A><Y><K><P><L><Y><S><W><E><E><A><K><Q><K><T><V><E><W><V><G><S><L><V><D><R><H><K><E><T><L><K><S><K><T><Q>
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.<BOP>
P26439
O14978
ZN263_HUMAN
Zinc finger protein with KRAB and SCAN domains 12
Homo
<M><A><S><G><P><G><S><Q><E><R><E><G><L><L><I><V><K><L><E><E><D><C><A><W><S><Q><E><L><P><P><P><D><P><G><P><S><P><E><A><S><H><L><R><F><R><R><F><R><F><Q><E><A><A><G><P><R><E><A><L><S><R><L><Q><E><L><C><H><G><W><L><R><P><E><M><R><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><I><L><P><Q><E><I><Q><S><R><V><Q><E><L><H><P><E><S><G><E><E><A><V><T><L><V><E><D><M><Q><R><E><L><G><R><L><R><Q><Q><V><T><N><H><G><R><G><T><E><V><L><L><E><E><P><L><P><L><E><T><A><R><E><S><P><S><F><K><L><E><P><M><E><T><E><R><S><P><G><P><R><L><Q><E><L><L><G><P><S><P><Q><R><D><P><Q><A><V><K><E><R><A><L><S><A><P><W><L><S><L><F><P><P><E><G><N><M><E><D><K><E><M><T><G><P><Q><L><P><E><S><L><E><D><V><A><M><Y><I><S><Q><E><E><W><G><H><Q><D><P><S><K><R><A><L><S><R><D><T><V><Q><E><S><Y><E><N><V><D><S><L><E><S><H><I><P><S><Q><E><V><P><G><T><Q><V><G><Q><G><G><K><L><W><D><P><S><V><Q><S><C><K><E><G><L><S><P><R><G><P><A><P><G><E><E><K><F><E><N><L><E><G><V><P><S><V><C><S><E><N><I><H><P><Q><V><L><L><P><D><Q><A><R><G><E><V><P><W><S><P><E><L><G><R><P><H><D><R><S><Q><G><D><W><A><P><P><P><E><G><G><M><E><Q><A><L><A><G><A><S><S><G><R><E><L><G><R><P><K><E><L><Q><P><K><K><L><H><L><C><P><L><C><G><K><N><F><S><N><N><S><N><L><I><R><H><Q><R><I><H><A><A><E><R><L><C><M><G><V><D><C><T><E><I><F><G><G><N><P><R><F><L><S><L><H><R><A><H><L><G><E><E><A><H><K><C><L><E><C><G><K><C><F><S><Q><N><T><H><L><T><R><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><N><I><C><G><K><C><F><S><C><N><S><N><L><H><R><H><Q><R><T><H><T><G><E><K><P><Y><K><C><P><E><C><G><E><I><F><A><H><S><S><N><L><L><R><H><Q><R><I><H><T><G><E><R><P><Y><K><C><P><E><C><G><K><S><F><S><R><S><S><H><L><V><I><H><E><R><T><H><E><R><E><R><L><Y><P><F><S><E><C><G><E><A><V><S><D><S><T><P><F><L><T><N><H><G><A><H><K><A><E><K><K><L><F><E><C><L><T><C><G><K><S><F><R><Q><G><M><H><L><T><R><H><Q><R><T><H><T><G><E><K><P><Y><K><C><T><L><C><G><E><N><F><S><H><R><S><N><L><I><R><H><Q><R><I><H><T><G><E><K><P><Y><T><C><H><E><C><G><D><S><F><S><H><S><S><N><R><I><R><H><L><R><T><H><T><G><E><R><P><Y><K><C><S><E><C><G><E><S><F><S><R><S><S><R><L><M><S><H><Q><R><T><H><T><G>
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor . Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression . Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions .<BOP>
O14978
Q9NP97
DLRB1_HUMAN
Roadblock domain-containing protein 1
null
<M><A><E><V><E><E><T><L><K><R><L><Q><S><Q><K><G><V><Q><G><I><I><V><V><N><T><E><G><I><P><I><K><S><T><M><D><N><P><T><T><T><Q><Y><A><S><L><M><H><S><F><I><L><K><A><R><S><T><V><R><D><I><D><P><Q><N><D><L><T><F><L><R><I><R><S><K><K><N><E><I><M><V><A><P><D><K><D><Y><F><L><I><V><I><Q><N><P><T><E>
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.<BOP>
Q9NP97
P17174
AATC_HUMAN
Transaminase A
Homo
<M><A><P><P><S><V><F><A><E><V><P><Q><A><Q><P><V><L><V><F><K><L><T><A><D><F><R><E><D><P><D><P><R><K><V><N><L><G><V><G><A><Y><R><T><D><D><C><H><P><W><V><L><P><V><V><K><K><V><E><Q><K><I><A><N><D><N><S><L><N><H><E><Y><L><P><I><L><G><L><A><E><F><R><S><C><A><S><R><L><A><L><G><D><D><S><P><A><L><K><E><K><R><V><G><G><V><Q><S><L><G><G><T><G><A><L><R><I><G><A><D><F><L><A><R><W><Y><N><G><T><N><N><K><N><T><P><V><Y><V><S><S><P><T><W><E><N><H><N><A><V><F><S><A><A><G><F><K><D><I><R><S><Y><R><Y><W><D><A><E><K><R><G><L><D><L><Q><G><F><L><N><D><L><E><N><A><P><E><F><S><I><V><V><L><H><A><C><A><H><N><P><T><G><I><D><P><T><P><E><Q><W><K><Q><I><A><S><V><M><K><H><R><F><L><F><P><F><F><D><S><A><Y><Q><G><F><A><S><G><N><L><E><R><D><A><W><A><I><R><Y><F><V><S><E><G><F><E><F><F><C><A><Q><S><F><S><K><N><F><G><L><Y><N><E><R><V><G><N><L><T><V><V><G><K><E><P><E><S><I><L><Q><V><L><S><Q><M><E><K><I><V><R><I><T><W><S><N><P><P><A><Q><G><A><R><I><V><A><S><T><L><S><N><P><E><L><F><E><E><W><T><G><N><V><K><T><M><A><D><R><I><L><T><M><R><S><E><L><R><A><R><L><E><A><L><K><T><P><G><T><W><N><H><I><T><D><Q><I><G><M><F><S><F><T><G><L><N><P><K><Q><V><E><Y><L><V><N><E><K><H><I><Y><L><L><P><S><G><R><I><N><V><S><G><L><T><T><K><N><L><D><Y><V><A><T><S><I><H><E><A><V><T><K><I><Q>
Biosynthesis of L-glutamate from L-aspartate or L-cysteine . Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway .<BOP>
P17174
Q9NZS9
BFAR_HUMAN
RING finger protein 47
Homo
<M><E><E><P><Q><K><S><Y><V><N><T><M><D><L><E><R><D><E><P><L><K><S><T><G><P><Q><I><S><V><S><E><F><S><C><H><C><C><Y><D><I><L><V><N><P><T><T><L><N><C><G><H><S><F><C><R><H><C><L><A><L><W><W><A><S><S><K><K><T><E><C><P><E><C><R><E><K><W><E><G><F><P><K><V><S><I><L><L><R><D><A><I><E><K><L><F><P><D><A><I><R><L><R><F><E><D><I><Q><Q><N><N><D><I><V><Q><S><L><A><A><F><Q><K><Y><G><N><D><Q><I><P><L><A><P><N><T><G><R><A><N><Q><Q><M><G><G><G><F><F><S><G><V><L><T><A><L><T><G><V><A><V><V><L><L><V><Y><H><W><S><S><R><E><S><E><H><D><L><L><V><H><K><A><V><A><K><W><T><A><E><E><V><V><L><W><L><E><Q><L><G><P><W><A><S><L><Y><R><E><R><F><L><S><E><R><V><N><G><R><L><L><L><T><L><T><E><E><E><F><S><K><T><P><Y><T><I><E><N><S><S><H><R><R><A><I><L><M><E><L><E><R><V><K><A><L><G><V><K><P><P><Q><N><L><W><E><Y><K><A><V><N><P><G><R><S><L><F><L><L><Y><A><L><K><S><S><P><R><L><S><L><L><Y><L><Y><L><F><D><Y><T><D><T><F><L><P><F><I><H><T><I><C><P><L><Q><E><D><S><S><G><E><D><I><V><T><K><L><L><D><L><K><E><P><T><W><K><Q><W><R><E><F><L><V><K><Y><S><F><L><P><Y><Q><L><I><A><E><F><A><W><D><W><L><E><V><H><Y><W><T><S><R><F><L><I><I><N><A><M><L><L><S><V><L><E><L><F><S><F><W><R><I><W><S><R><S><E><L><K><T><V><P><Q><R><M><W><S><H><F><W><K><V><S><T><Q><G><L><F><V><A><M><F><W><P><L><I><P><Q><F><V><C><N><C><L><F><Y><W><A><L><Y><F><N><P><I><I><N><I><D><L><V><V><K><E><L><R><R><L><E><T><Q><V><L>
Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.<BOP>
Q9NZS9
Q8TCX1
DC2L1_HUMAN
Cytoplasmic dynein 2 light intermediate chain 1
Homo
<M><P><S><E><T><L><W><E><I><A><K><A><E><V><E><K><R><G><I><N><G><S><E><G><D><G><A><E><I><A><E><K><F><V><F><F><I><G><S><K><N><G><G><K><T><T><I><I><L><R><C><L><D><R><D><E><P><P><K><P><T><L><A><L><E><Y><T><Y><G><R><R><A><K><G><H><N><T><P><K><D><I><A><H><F><W><E><L><G><G><G><T><S><L><L><D><L><I><S><I><P><I><T><G><D><T><L><R><T><F><S><L><V><L><V><L><D><L><S><K><P><N><D><L><W><P><T><M><E><N><L><L><Q><A><T><K><S><H><V><D><K><V><I><M><K><L><G><K><T><N><A><K><A><V><S><E><M><R><Q><K><I><W><N><N><M><P><K><D><H><P><D><H><E><L><I><D><P><F><P><V><P><L><V><I><I><G><S><K><Y><D><V><F><Q><D><F><E><S><E><K><R><K><V><I><C><K><T><L><R><F><V><A><H><Y><Y><G><A><S><L><M><F><T><S><K><S><E><A><L><L><L><K><I><R><G><V><I><N><Q><L><A><F><G><I><D><K><S><K><S><I><C><V><D><Q><N><K><P><L><F><I><T><A><G><L><D><S><F><G><Q><I><G><S><P><P><V><P><E><N><D><I><G><K><L><H><A><H><S><P><M><E><L><W><K><K><V><Y><E><K><L><F><P><P><K><S><I><N><T><L><K><D><I><K><D><P><A><R><D><P><Q><Y><A><E><N><E><V><D><E><M><R><I><Q><K><D><L><E><L><E><Q><Y><K><R><S><S><S><K><S><W><K><Q><I><E><L><D><S>
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles . Involved in the regulation of ciliary length .<BOP>
Q8TCX1
O00476
NPT4_HUMAN
Solute carrier family 17 member 3
Homo
<M><A><T><K><T><E><L><S><P><T><A><R><E><S><K><N><A><Q><D><M><Q><V><D><E><T><L><I><P><R><K><V><P><S><L><C><S><A><R><Y><G><I><A><L><V><L><H><F><C><N><F><T><T><I><A><Q><N><V><I><M><N><I><T><M><V><A><M><V><N><S><T><S><P><Q><S><Q><L><N><D><S><S><E><V><L><P><V><D><S><F><G><G><L><S><K><A><P><K><S><L><P><A><K><S><S><I><L><G><G><Q><F><A><I><W><E><K><W><G><P><P><Q><E><R><S><R><L><C><S><I><A><L><S><G><M><L><L><G><C><F><T><A><I><L><I><G><G><F><I><S><E><T><L><G><W><P><F><V><F><Y><I><F><G><G><V><G><C><V><C><C><L><L><W><F><V><V><I><Y><D><D><P><V><S><Y><P><W><I><S><T><S><E><K><E><Y><I><I><S><S><L><K><Q><Q><V><G><S><S><K><Q><P><L><P><I><K><A><M><L><R><S><L><P><I><W><S><I><C><L><G><C><F><S><H><Q><W><L><V><S><T><M><V><V><Y><I><P><T><Y><I><S><S><V><Y><H><V><N><I><R><D><N><G><L><L><S><A><L><P><F><I><V><A><W><V><I><G><M><V><G><G><Y><L><A><D><F><L><L><T><K><K><F><R><L><I><T><V><R><K><I><A><T><I><L><G><S><L><P><S><S><A><L><I><V><S><L><P><Y><L><N><S><G><Y><I><T><A><T><A><L><L><T><L><S><C><G><L><S><T><L><C><Q><S><G><I><Y><I><N><V><L><D><I><A><P><R><Y><S><S><F><L><M><G><A><S><R><G><F><S><S><I><A><P><V><I><V><P><T><V><S><G><F><L><L><S><Q><D><P><E><F><G><W><R><N><V><F><F><L><L><F><A><V><N><L><L><G><L><L><F><Y><L><I><F><G><E><A><D><V><Q><E><W><A><K><E><R><K><L><T><R><L>
Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule . In particular, participates in the secretion of urate from the cell into the lumen . Urate is the end product of purine metabolism . May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide .<BOP>
O00476
Q08334
I10R2_HUMAN
Interleukin-10 receptor subunit 2
Homo
<M><A><W><S><L><G><S><W><L><G><G><C><L><L><V><S><A><L><G><M><V><P><P><P><E><N><V><R><M><N><S><V><N><F><K><N><I><L><Q><W><E><S><P><A><F><A><K><G><N><L><T><F><T><A><Q><Y><L><S><Y><R><I><F><Q><D><K><C><M><N><T><T><L><T><E><C><D><F><S><S><L><S><K><Y><G><D><H><T><L><R><V><R><A><E><F><A><D><E><H><S><D><W><V><N><I><T><F><C><P><V><D><D><T><I><I><G><P><P><G><M><Q><V><E><V><L><A><D><S><L><H><M><R><F><L><A><P><K><I><E><N><E><Y><E><T><W><T><M><K><N><V><Y><N><S><W><T><Y><N><V><Q><Y><W><K><N><G><T><D><E><K><F><Q><I><T><P><Q><Y><D><F><E><V><L><R><N><L><E><P><W><T><T><Y><C><V><Q><V><R><G><F><L><P><D><R><N><K><A><G><E><W><S><E><P><V><C><E><Q><T><T><H><D><E><T><V><P><S><W><M><V><A><V><I><L><M><A><S><V><F><M><V><C><L><A><L><L><G><C><F><A><L><L><W><C><V><Y><K><K><T><K><Y><A><F><S><P><R><N><S><L><P><Q><H><L><K><E><F><L><G><H><P><H><H><N><T><L><L><F><F><S><F><P><L><S><D><E><N><D><V><F><D><K><L><S><V><I><A><E><D><S><E><S><G><K><Q><N><P><G><D><S><C><S><L><G><T><P><P><G><Q><G><P><Q><S>
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.<BOP>
Q08334
Q8TC94
ACTL9_HUMAN
Actin-like protein 9
Homo
<M><D><A><S><R><P><K><S><S><E><S><Q><S><S><L><E><A><P><R><P><G><P><N><P><S><P><N><V><V><N><K><P><L><Q><R><D><S><P><G><M><V><A><D><R><L><P><P><K><T><G><A><V><V><I><D><M><G><T><G><T><C><K><V><G><F><A><G><Q><A><S><P><T><Y><T><V><A><T><I><L><G><C><Q><P><K><K><P><A><T><S><G><Q><S><G><L><Q><T><F><I><G><E><A><A><R><V><L><P><E><L><T><L><V><Q><P><L><R><S><G><I><V><V><D><W><D><A><A><E><L><I><W><R><H><L><L><E><H><D><L><R><V><A><T><H><D><H><P><L><L><F><S><D><P><P><F><S><P><A><T><N><R><E><K><L><V><E><V><A><F><E><S><L><R><S><P><A><M><Y><V><A><S><Q><S><V><L><S><V><Y><A><H><G><R><V><S><G><L><V><V><D><T><G><H><G><V><T><Y><T><V><P><V><F><Q><G><Y><N><L><L><H><A><T><E><R><L><D><L><A><G><N><N><L><T><A><F><L><A><E><M><L><L><Q><A><G><L><P><L><G><Q><Q><D><L><D><L><V><E><N><I><K><H><H><Y><C><Y><V><A><S><D><F><Q><K><E><Q><A><R><P><E><Q><E><Y><K><R><T><L><K><L><P><D><G><R><T><V><T><L><G><K><E><L><F><Q><C><P><E><L><L><F><N><P><P><E><V><P><G><L><S><P><V><G><L><S><T><M><A><K><Q><S><L><R><K><L><S><L><E><M><R><A><D><L><A><Q><N><V><L><L><C><G><G><S><S><L><F><T><G><F><E><G><R><F><R><A><E><L><L><R><A><L><P><A><E><T><H><V><V><V><A><A><Q><P><T><R><N><F><S><V><W><I><G><G><S><I><L><A><S><L><R><A><F><Q><S><C><W><V><L><R><E><Q><Y><E><E><Q><G><P><Y><I><V><Y><R><K><C><Y>
Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.<BOP>
Q8TC94
Q5W0U4
BSPRY_HUMAN
B box and SPRY domain-containing protein
Homo
<M><S><A><E><G><A><E><P><G><P><G><S><G><S><G><P><G><P><G><P><L><C><P><E><H><G><Q><A><L><S><W><F><C><G><S><E><R><R><P><V><C><A><A><C><A><G><L><G><G><R><C><R><G><H><R><I><R><R><A><E><E><R><A><E><E><L><R><N><K><I><V><D><Q><C><E><R><L><Q><L><Q><S><A><A><I><T><K><Y><V><A><D><V><L><P><G><K><N><Q><R><A><V><S><M><A><S><A><A><R><E><L><V><I><Q><R><L><S><L><V><R><S><L><C><E><S><E><E><Q><R><L><L><E><Q><V><H><G><E><E><E><R><A><H><Q><S><I><L><T><Q><R><V><H><W><A><E><A><L><Q><K><L><D><T><I><R><T><G><L><V><G><M><L><T><H><L><D><D><L><Q><L><I><Q><K><E><Q><E><I><F><E><R><T><E><E><A><E><G><I><L><D><P><Q><E><S><E><M><L><N><F><N><E><K><C><T><R><S><P><L><L><T><Q><L><W><A><T><A><V><L><G><S><L><S><G><T><E><D><I><R><I><D><E><R><T><V><S><P><F><L><Q><L><S><D><D><R><K><T><L><T><F><S><T><K><K><S><K><A><C><A><D><G><P><E><R><F><D><H><W><P><N><A><L><A><A><T><S><F><Q><N><G><L><H><A><W><M><V><N><V><Q><N><S><C><A><Y><K><V><G><V><A><S><G><H><L><P><R><K><G><S><G><S><D><C><R><L><G><H><N><A><F><S><W><V><F><S><R><Y><D><Q><E><F><R><F><S><H><N><G><Q><H><E><P><L><G><L><L><R><G><P><A><Q><L><G><V><V><L><D><L><Q><V><Q><E><L><L><F><Y><E><P><A><S><G><T><V><L><C><A><H><H><V><S><F><P><G><P><L><F><P><V><F><A><V><A><D><Q><T><I><S><I><V><R>
May regulate epithelial calcium transport by inhibiting TRPV5 activity.<BOP>
Q5W0U4
A0A0B4J262
TVA86_HUMAN
T cell receptor alpha variable 8-6
Homo
<M><L><L><L><L><V><P><A><F><Q><V><I><F><T><L><G><G><T><R><A><Q><S><V><T><Q><L><D><S><Q><V><P><V><F><E><E><A><P><V><E><L><R><C><N><Y><S><S><S><V><S><V><Y><L><F><W><Y><V><Q><Y><P><N><Q><G><L><Q><L><L><L><K><Y><L><S><G><S><T><L><V><E><S><I><N><G><F><E><A><E><F><N><K><S><Q><T><S><F><H><L><R><K><P><S><V><H><I><S><D><T><A><E><Y><F><C><A><V><S>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A0B4J262
Q96P71
NECA3_HUMAN
X11L-binding protein 51
Homo
<M><A><C><A><G><L><L><T><V><C><L><L><R><P><P><A><P><Q><P><Q><P><Q><T><P><R><H><P><Q><L><A><P><D><P><G><P><A><G><H><T><L><F><Q><D><V><F><R><R><A><D><K><N><D><D><G><K><L><S><F><E><E><F><Q><N><Y><F><A><D><G><V><L><S><L><G><E><L><Q><E><L><F><S><G><I><D><G><H><L><T><D><N><L><E><T><E><K><L><C><D><Y><F><S><E><H><L><G><V><Y><R><P><V><L><A><A><L><E><S><L><N><R><A><V><L><A><A><M><D><A><T><K><L><E><Y><E><R><A><S><K><V><D><Q><F><V><T><R><F><L><L><R><E><T><V><S><Q><L><Q><A><L><Q><S><S><L><E><G><A><S><D><T><L><E><A><Q><A><H><G><W><R><S><D><A><E><S><V><E><A><Q><S><R><L><C><G><S><R><R><A><G><R><R><A><L><R><S><V><S><R><S><S><T><W><S><P><G><S><S><D><T><G><R><S><S><E><A><E><M><Q><W><R><L><Q><V><N><R><L><Q><E><L><I><D><Q><L><E><C><K><V><R><A><V><G><P><G><P><H><K><G><G><P><S><W><Y><P><P><E><P><G><P><C><W><R><P><G><P><H><S><V><P><S><Q><A><P><R><L><E><P><L><R><E><E><D><L><A><K><G><P><D><L><H><I><L><M><A><Q><R><Q><V><Q><V><A><E><E><G><L><Q><D><F><H><R><A><L><R><C><Y><V><D><F><T><G><A><Q><S><H><C><L><H><V><S><A><Q><K><M><L><D><G><A><S><F><T><L><Y><E><F><W><Q><D><E><A><S><W><R><R><H><Q><Q><S><P><G><S><K><A><F><Q><R><I><L><I><D><H><L><R><A><P><D><T><L><T><T><V><F><F><P><A><S><W><W><I><M><N><N><N>
Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.<BOP>
Q96P71
Q13641
TPBG_HUMAN
Wnt-activated inhibitory factor 1
Homo
<M><P><G><G><C><S><R><G><P><A><A><G><D><G><R><L><R><L><A><R><L><A><L><V><L><L><G><W><V><S><S><S><S><P><T><S><S><A><S><S><F><S><S><S><A><P><F><L><A><S><A><V><S><A><Q><P><P><L><P><D><Q><C><P><A><L><C><E><C><S><E><A><A><R><T><V><K><C><V><N><R><N><L><T><E><V><P><T><D><L><P><A><Y><V><R><N><L><F><L><T><G><N><Q><L><A><V><L><P><A><G><A><F><A><R><R><P><P><L><A><E><L><A><A><L><N><L><S><G><S><R><L><D><E><V><R><A><G><A><F><E><H><L><P><S><L><R><Q><L><D><L><S><H><N><P><L><A><D><L><S><P><F><A><F><S><G><S><N><A><S><V><S><A><P><S><P><L><V><E><L><I><L><N><H><I><V><P><P><E><D><E><R><Q><N><R><S><F><E><G><M><V><V><A><A><L><L><A><G><R><A><L><Q><G><L><R><R><L><E><L><A><S><N><H><F><L><Y><L><P><R><D><V><L><A><Q><L><P><S><L><R><H><L><D><L><S><N><N><S><L><V><S><L><T><Y><V><S><F><R><N><L><T><H><L><E><S><L><H><L><E><D><N><A><L><K><V><L><H><N><G><T><L><A><E><L><Q><G><L><P><H><I><R><V><F><L><D><N><N><P><W><V><C><D><C><H><M><A><D><M><V><T><W><L><K><E><T><E><V><V><Q><G><K><D><R><L><T><C><A><Y><P><E><K><M><R><N><R><V><L><L><E><L><N><S><A><D><L><D><C><D><P><I><L><P><P><S><L><Q><T><S><Y><V><F><L><G><I><V><L><A><L><I><G><A><I><F><L><L><V><L><Y><L><N><R><K><G><I><K><K><W><M><H><N><I><R><D><A><C><R><D><H><M><E><G><Y><H><Y><R><Y><E><I><N><A><D><P><R><L><T><N><L><S><S><N><S><D><V>
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.<BOP>
Q13641
O95866
G6B_HUMAN
Protein G6b
Homo
<M><A><V><F><L><Q><L><L><P><L><L><L><S><R><A><Q><G><N><P><G><A><S><L><D><G><R><P><G><D><R><V><N><L><S><C><G><G><V><S><H><P><I><R><W><V><W><A><P><S><F><P><A><C><K><G><L><S><K><G><R><R><P><I><L><W><A><S><S><S><G><T><P><T><V><P><P><L><Q><P><F><V><G><R><L><R><S><L><D><S><G><I><R><R><L><E><L><L><L><S><A><G><D><S><G><T><F><F><C><K><G><R><H><E><D><E><S><R><T><V><L><H><V><L><G><D><R><T><Y><C><K><A><P><G><P><T><H><G><S><V><Y><P><Q><L><L><I><P><L><L><G><A><G><L><V><L><G><L><G><A><L><G><L><V><W><W><L><H><R><R><L><P><P><Q><P><I><R><P><L><P><R><F><A><P><L><V><K><T><E><P><Q><R><P><V><K><E><E><E><P><K><I><P><G><D><L><D><Q><E><P><S><L><L><Y><A><D><L><D><H><L><A><L><S><R><P><R><R><L><S><T><A><D><P><A><D><A><S><T><I><Y><A><V><V><V>
Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.<BOP>
O95866
Q8NGP9
O5AR1_HUMAN
Olfactory receptor OR11-209
Homo
<M><D><K><E><N><S><S><M><V><T><E><F><I><F><M><G><I><T><Q><D><P><Q><M><E><I><I><F><F><V><V><F><L><I><V><Y><L><V><N><V><V><G><N><I><G><M><I><I><L><I><T><T><D><T><Q><L><H><T><P><M><Y><F><F><L><C><N><L><S><F><V><D><L><G><Y><S><S><A><I><A><P><R><M><L><A><D><F><L><T><N><H><K><V><I><S><F><S><S><C><A><T><Q><F><A><F><F><V><G><F><V><D><A><E><C><Y><V><L><A><A><M><A><Y><G><R><F><V><A><I><C><R><P><L><H><Y><S><T><F><M><S><K><Q><V><C><L><A><L><M><L><G><S><Y><L><A><G><L><V><S><L><V><A><H><T><T><L><T><F><S><L><S><Y><C><G><S><N><I><I><N><H><F><F><C><E><I><P><P><L><L><A><L><S><C><S><D><T><Y><I><S><E><I><L><L><F><S><L><C><G><F><I><E><F><S><T><I><L><I><I><F><I><S><Y><T><F><I><L><V><A><I><I><R><M><R><S><A><E><G><R><L><K><A><F><S><T><C><G><S><H><L><T><G><I><T><L><F><Y><G><T><V><M><F><M><Y><L><R><P><T><S><S><Y><S><L><D><Q><D><K><W><A><S><V><F><Y><T><V><I><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><A><A><F><K><K><L><I><G><K><K><S><Q>
Odorant receptor.<BOP>
Q8NGP9
Q9BZQ2
SHP1L_HUMAN
SHC SH2 domain-binding protein 1-like protein
Homo
<M><A><S><G><S><K><A><S><V><P><A><D><S><F><R><T><I><S><P><D><R><R><G><E><K><S><A><S><A><V><S><G><D><T><A><A><A><T><T><L><K><G><T><A><I><P><V><R><S><V><V><A><S><P><R><P><V><K><G><K><A><G><R><E><T><A><R><L><R><L><Q><R><L><P><A><A><Q><A><E><D><T><G><E><A><A><A><A><A><A><E><E><P><L><L><P><V><P><E><D><E><E><E><A><Q><P><L><P><P><V><C><V><S><R><M><R><G><M><W><R><D><E><K><V><S><L><Y><C><D><E><V><L><Q><D><C><K><A><E><D><A><D><E><V><M><G><K><Y><L><S><E><K><L><K><L><K><D><K><W><L><G><V><W><K><T><N><P><S><V><F><F><V><K><Y><E><E><A><S><I><P><F><V><G><I><L><V><E><V><T><C><E><P><Y><Q><D><S><S><S><R><F><K><V><T><V><S><V><A><E><P><F><S><S><N><I><A><N><I><P><R><D><L><V><D><E><I><L><E><E><L><E><H><S><V><P><L><L><E><V><Y><P><V><E><G><Q><D><T><D><I><H><V><I><A><L><A><L><E><V><V><R><F><F><Y><D><F><L><W><R><D><W><D><D><E><E><S><C><E><N><Y><T><A><L><I><E><E><R><I><N><L><W><C><D><I><Q><D><G><T><I><P><G><P><I><A><Q><R><F><K><K><T><L><E><K><Y><K><N><K><R><V><E><L><I><E><Y><Q><S><N><I><K><E><D><P><S><A><A><E><A><V><E><C><W><K><K><Y><Y><E><I><V><M><L><C><G><L><L><K><M><W><E><D><L><R><L><R><V><H><G><P><F><F><P><R><I><L><R><R><R><K><G><K><R><E><F><G><K><T><I><T><H><I><V><A><K><M><M><T><T><E><M><I><K><D><L><S><S><D><T><L><L><Q><Q><H><G><D><L><D><L><A><L><D><N><C><Y><S><G><D><T><V><I><I><F><P><G><E><Y><Q><A><A><N><L><A><L><L><T><D><D><I><I><I><K><G><V><G><K><R><E><E><I><M><I><T><S><E><P><S><R><D><S><F><V><V><S><K><A><D><N><V><K><L><M><H><L><S><L><I><Q><Q><G><T><V><D><G><I><V><V><V><E><S><G><H><M><T><L><E><N><C><I><L><K><C><E><G><T><G><V><C><V><L><T><G><A><A><L><T><I><T><D><S><E><I><T><G><A><Q><G><A><G><V><E><L><Y><P><G><S><I><A><I><L><E><R><N><E><I><H><H><C><N><N><L><R><T><S><N><S><S><K><S><T><L><G><G><V><N><M><K><V><L><P><A><P><K><L><K><M><T><N><N><H><I><Y><S><N><K><G><Y><G><V><S><I><L><Q><P><M><E><Q><F><F><I><V><A><E><E><A><L><N><K><R><A><S><S><G><D><K><K><D><D><K><M><L><F><K><V><M><Q><N><L><N><L><E><M><N><N><N><K><I><E><A><N><V><K><G><D><I><R><I><V><T><S>
Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells.<BOP>
Q9BZQ2
P56559
ARL4C_HUMAN
ADP-ribosylation factor-like protein LAK
Homo
<M><G><N><I><S><S><N><I><S><A><F><Q><S><L><H><I><V><M><L><G><L><D><S><A><G><K><T><T><V><L><Y><R><L><K><F><N><E><F><V><N><T><V><P><T><I><G><F><N><T><E><K><I><K><L><S><N><G><T><A><K><G><I><S><C><H><F><W><D><V><G><G><Q><E><K><L><R><P><L><W><K><S><Y><S><R><C><T><D><G><I><I><Y><V><V><D><S><V><D><V><D><R><L><E><E><A><K><T><E><L><H><K><V><T><K><F><A><E><N><Q><G><T><P><L><L><V><I><A><N><K><Q><D><L><P><K><S><L><P><V><A><E><I><E><K><Q><L><A><L><H><E><L><I><P><A><T><T><Y><H><V><Q><P><A><C><A><I><I><G><E><G><L><T><E><G><M><D><K><L><Y><E><M><I><L><K><R><R><K><S><L><K><Q><K><K><K><R>
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.<BOP>
P56559
Q00526
CDK3_HUMAN
Cell division protein kinase 3
Homo
<M><D><M><F><Q><K><V><E><K><I><G><E><G><T><Y><G><V><V><Y><K><A><K><N><R><E><T><G><Q><L><V><A><L><K><K><I><R><L><D><L><E><M><E><G><V><P><S><T><A><I><R><E><I><S><L><L><K><E><L><K><H><P><N><I><V><R><L><L><D><V><V><H><N><E><R><K><L><Y><L><V><F><E><F><L><S><Q><D><L><K><K><Y><M><D><S><T><P><G><S><E><L><P><L><H><L><I><K><S><Y><L><F><Q><L><L><Q><G><V><S><F><C><H><S><H><R><V><I><H><R><D><L><K><P><Q><N><L><L><I><N><E><L><G><A><I><K><L><A><D><F><G><L><A><R><A><F><G><V><P><L><R><T><Y><T><H><E><V><V><T><L><W><Y><R><A><P><E><I><L><L><G><S><K><F><Y><T><T><A><V><D><I><W><S><I><G><C><I><F><A><E><M><V><T><R><K><A><L><F><P><G><D><S><E><I><D><Q><L><F><R><I><F><R><M><L><G><T><P><S><E><D><T><W><P><G><V><T><Q><L><P><D><Y><K><G><S><F><P><K><W><T><R><K><G><L><E><E><I><V><P><N><L><E><P><E><G><R><D><L><L><M><Q><L><L><Q><Y><D><P><S><Q><R><I><T><A><K><T><A><L><A><H><P><Y><F><S><S><P><E><P><S><P><A><A><R><Q><Y><V><L><Q><R><F><R><H>
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.<BOP>
Q00526
Q3LI59
KR212_HUMAN
Keratin-associated protein 21-2
Homo
<M><C><C><N><Y><Y><R><N><C><C><G><G><C><G><Y><G><S><G><W><S><S><G><C><G><Y><G><C><G><Y><G><C><G><Y><G><S><G><C><R><Y><G><S><G><Y><G><T><G><C><G><Y><G><C><G><Y><G><S><G><C><G><Y><G><C><G><Y><S><S><S><C><C><G><Y><R><P><L><C><Y><R><R><C><Y><S><S><C><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q3LI59
Q8NGX9
OR6P1_HUMAN
Olfactory receptor OR1-12
Homo
<M><R><N><L><S><G><G><H><V><E><E><F><V><L><V><G><F><P><T><T><P><P><L><Q><L><L><L><F><V><L><F><F><A><I><Y><L><L><T><L><L><E><N><A><L><I><V><F><T><I><W><L><A><P><S><L><H><R><P><M><Y><F><F><L><G><H><L><S><F><L><E><L><W><Y><I><N><V><T><I><P><R><L><L><A><A><F><L><T><Q><D><G><R><V><S><Y><V><G><C><M><T><Q><L><Y><F><F><I><A><L><A><C><T><E><C><V><L><L><A><V><M><A><Y><D><R><Y><L><A><I><C><G><P><L><L><Y><P><S><L><M><P><S><S><L><A><T><R><L><A><A><A><S><W><G><S><G><F><F><S><S><M><M><K><L><L><F><I><S><Q><L><S><Y><C><G><P><N><I><I><N><H><F><F><C><D><I><S><P><L><L><N><L><T><C><S><D><K><E><Q><A><E><L><V><D><F><L><L><A><L><V><M><I><L><L><P><L><L><A><V><V><S><S><Y><T><A><I><I><A><A><I><L><R><I><P><T><S><R><G><R><H><K><A><F><S><T><C><A><A><H><L><A><V><V><V><I><Y><Y><S><S><T><L><F><T><Y><A><R><P><R><A><M><Y><T><F><N><H><N><K><I><I><S><V><L><Y><T><I><I><V><P><F><F><N><P><A><I><Y><C><L><R><N><K><E><V><K><E><A><F><R><K><T><V><M><G><R><C><H><Y><P><R><D><V><Q><D>
Odorant receptor.<BOP>
Q8NGX9
P58418
CLRN1_HUMAN
Usher syndrome type-3 protein
Homo
<M><P><S><Q><Q><K><K><I><I><F><C><M><A><G><V><F><S><F><A><C><A><L><G><V><V><T><A><L><G><T><P><L><W><I><K><A><T><V><L><C><K><T><G><A><L><L><V><N><A><S><G><Q><E><L><D><K><F><M><G><E><M><Q><Y><G><L><F><H><G><E><G><V><R><Q><C><G><L><G><A><R><P><F><R><F><S><F><F><P><D><L><L><K><A><I><P><V><S><I><H><V><N><V><I><L><F><S><A><I><L><I><V><L><T><M><V><G><T><A><F><F><M><Y><N><A><F><G><K><P><F><E><T><L><H><G><P><L><G><L><Y><L><L><S><F><I><S><G><S><C><G><C><L><V><M><I><L><F><A><S><E><V><K><I><H><H><L><S><E><K><I><A><N><Y><K><E><G><T><Y><V><Y><K><T><Q><S><E><K><Y><T><T><S><F><W><V><I><F><F><C><F><F><V><H><F><L><N><G><L><L><I><R><L><A><G><F><Q><F><P><F><A><K><S><K><D><A><E><T><T><N><V><A><A><D><L><M><Y>
May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.<BOP>
P58418
Q9NVV0
TM38B_HUMAN
Transmembrane protein 38B
Homo
<M><D><S><P><W><D><E><L><A><L><A><F><S><R><T><S><M><F><P><F><F><D><I><A><H><Y><L><V><S><V><M><A><V><K><R><Q><P><G><A><A><A><L><A><W><K><N><P><I><S><S><W><F><T><A><M><L><H><C><F><G><G><G><I><L><S><C><L><L><L><A><E><P><P><L><K><F><L><A><N><H><T><N><I><L><L><A><S><S><I><W><Y><I><T><F><F><C><P><H><D><L><V><S><Q><G><Y><S><Y><L><P><V><Q><L><L><A><S><G><M><K><E><V><T><R><T><W><K><I><V><G><G><V><T><H><A><N><S><Y><Y><K><N><G><W><I><V><M><I><A><I><G><W><A><R><G><A><G><G><T><I><I><T><N><F><E><R><L><V><K><G><D><W><K><P><E><G><D><E><W><L><K><M><S><Y><P><A><K><V><T><L><L><G><S><V><I><F><T><F><Q><H><T><Q><H><L><A><I><S><K><H><N><L><M><F><L><Y><T><I><F><I><V><A><T><K><I><T><M><M><T><T><Q><T><S><T><M><T><F><A><P><F><E><D><T><L><S><W><M><L><F><G><W><Q><Q><P><F><S><S><C><E><K><K><S><E><A><K><S><P><S><N><G><V><G><S><L><A><S><K><P><V><D><V><A><S><D><N><V><K><K><K><H><T><K><K><N><E>
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.<BOP>
Q9NVV0
Q8NHK3
KI2LB_HUMAN
Killer cell immunoglobulin-like receptor 2DLX
Homo
<M><S><L><M><V><V><S><M><A><C><V><G><F><F><L><L><Q><G><A><W><T><H><E><G><G><Q><D><K><P><L><L><S><A><W><P><S><A><V><V><P><R><G><G><H><V><T><L><L><C><R><S><R><L><G><F><T><I><F><S><L><Y><K><E><D><G><V><P><V><P><E><L><Y><N><K><I><F><W><K><S><I><L><M><G><P><V><T><P><A><H><A><G><T><Y><R><C><R><G><S><H><P><R><S><P><I><E><W><S><A><P><S><N><P><L><V><I><V><V><T><G><L><F><G><K><P><S><L><S><A><Q><P><G><P><T><V><R><T><G><E><N><V><T><L><S><C><S><S><R><S><S><F><D><M><Y><H><L><S><R><E><G><R><A><H><E><P><R><L><P><A><V><P><S><V><D><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><G><T><Y><T><C><F><S><S><L><H><D><S><P><Y><E><W><S><D><P><S><D><P><L><L><V><S><V><T><G><N><S><S><S><S><S><S><S><P><T><E><P><S><S><K><T><G><I><R><R><H><L><H><I><L><I><G><T><S><V><A><I><I><L><F><I><I><L><F><F><F><L><L><H><C><C><C><S><N><K><K><N><A><A><V><M><D><Q><E><P><A><G><D><R><T><V><N><R><E><D><S><D><D><Q><D><P><Q><E><V><T><Y><A><Q><L><D><H><C><V><F><T><Q><T><K><I><T><S><P><S><Q><R><P><K><T><P><P><T><D><T><T><M><Y><M><E><L><P><N><A><K><P><R><S><L><S><P><A><H><K><H><H><S><Q><A><L><R><G><S><S><R><E><T><T><A><L><S><Q><N><R><V><A><S><S><H><V><P><A><A><G><I>
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.<BOP>
Q8NHK3
P06127
CD5_HUMAN
Lymphocyte antigen T1/Leu-1
Homo
<M><P><M><G><S><L><Q><P><L><A><T><L><Y><L><L><G><M><L><V><A><S><C><L><G><R><L><S><W><Y><D><P><D><F><Q><A><R><L><T><R><S><N><S><K><C><Q><G><Q><L><E><V><Y><L><K><D><G><W><H><M><V><C><S><Q><S><W><G><R><S><S><K><Q><W><E><D><P><S><Q><A><S><K><V><C><Q><R><L><N><C><G><V><P><L><S><L><G><P><F><L><V><T><Y><T><P><Q><S><S><I><I><C><Y><G><Q><L><G><S><F><S><N><C><S><H><S><R><N><D><M><C><H><S><L><G><L><T><C><L><E><P><Q><K><T><T><P><P><T><T><R><P><P><P><T><T><T><P><E><P><T><A><P><P><R><L><Q><L><V><A><Q><S><G><G><Q><H><C><A><G><V><V><E><F><Y><S><G><S><L><G><G><T><I><S><Y><E><A><Q><D><K><T><Q><D><L><E><N><F><L><C><N><N><L><Q><C><G><S><F><L><K><H><L><P><E><T><E><A><G><R><A><Q><D><P><G><E><P><R><E><H><Q><P><L><P><I><Q><W><K><I><Q><N><S><S><C><T><S><L><E><H><C><F><R><K><I><K><P><Q><K><S><G><R><V><L><A><L><L><C><S><G><F><Q><P><K><V><Q><S><R><L><V><G><G><S><S><I><C><E><G><T><V><E><V><R><Q><G><A><Q><W><A><A><L><C><D><S><S><S><A><R><S><S><L><R><W><E><E><V><C><R><E><Q><Q><C><G><S><V><N><S><Y><R><V><L><D><A><G><D><P><T><S><R><G><L><F><C><P><H><Q><K><L><S><Q><C><H><E><L><W><E><R><N><S><Y><C><K><K><V><F><V><T><C><Q><D><P><N><P><A><G><L><A><A><G><T><V><A><S><I><I><L><A><L><V><L><L><V><V><L><L><V><V><C><G><P><L><A><Y><K><K><L><V><K><K><F><R><Q><K><K><Q><R><Q><W><I><G><P><T><G><M><N><Q><N><M><S><F><H><R><N><H><T><A><T><V><R><S><H><A><E><N><P><T><A><S><H><V><D><N><E><Y><S><Q><P><P><R><N><S><H><L><S><A><Y><P><A><L><E><G><A><L><H><R><S><S><M><Q><P><D><N><S><S><D><S><D><Y><D><L><H><G><A><Q><R><L>
May act as a receptor in regulating T-cell proliferation.<BOP>
P06127
Q9H9S0
NANOG_HUMAN
Homeobox transcription factor Nanog
Homo
<M><S><V><D><P><A><C><P><Q><S><L><P><C><F><E><A><S><D><C><K><E><S><S><P><M><P><V><I><C><G><P><E><E><N><Y><P><S><L><Q><M><S><S><A><E><M><P><H><T><E><T><V><S><P><L><P><S><S><M><D><L><L><I><Q><D><S><P><D><S><S><T><S><P><K><G><K><Q><P><T><S><A><E><K><S><V><A><K><K><E><D><K><V><P><V><K><K><Q><K><T><R><T><V><F><S><S><T><Q><L><C><V><L><N><D><R><F><Q><R><Q><K><Y><L><S><L><Q><Q><M><Q><E><L><S><N><I><L><N><L><S><Y><K><Q><V><K><T><W><F><Q><N><Q><R><M><K><S><K><R><W><Q><K><N><N><W><P><K><N><S><N><G><V><T><Q><K><A><S><A><P><T><Y><P><S><L><Y><S><S><Y><H><Q><G><C><L><V><N><P><T><G><N><L><P><M><W><S><N><Q><T><W><N><N><S><T><W><S><N><Q><T><Q><N><I><Q><S><W><S><N><H><S><W><N><T><Q><T><W><C><T><Q><S><W><N><N><Q><A><W><N><S><P><F><Y><N><C><G><E><E><S><L><Q><S><C><M><Q><F><Q><P><N><S><P><A><S><D><L><E><A><A><L><E><A><A><G><E><G><L><N><V><I><Q><Q><T><T><R><Y><F><S><T><P><Q><T><M><D><L><F><L><N><Y><S><M><N><M><Q><P><E><D><V>
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter . Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.<BOP>
Q9H9S0
P47901
V1BR_HUMAN
Vasopressin V3 receptor
Homo
<M><D><S><G><P><L><W><D><A><N><P><T><P><R><G><T><L><S><A><P><N><A><T><T><P><W><L><G><R><D><E><E><L><A><K><V><E><I><G><V><L><A><T><V><L><V><L><A><T><G><G><N><L><A><V><L><L><T><L><G><Q><L><G><R><K><R><S><R><M><H><L><F><V><L><H><L><A><L><T><D><L><A><V><A><L><F><Q><V><L><P><Q><L><L><W><D><I><T><Y><R><F><Q><G><P><D><L><L><C><R><A><V><K><Y><L><Q><V><L><S><M><F><A><S><T><Y><M><L><L><A><M><T><L><D><R><Y><L><A><V><C><H><P><L><R><S><L><Q><Q><P><G><Q><S><T><Y><L><L><I><A><A><P><W><L><L><A><A><I><F><S><L><P><Q><V><F><I><F><S><L><R><E><V><I><Q><G><S><G><V><L><D><C><W><A><D><F><G><F><P><W><G><P><R><A><Y><L><T><W><T><T><L><A><I><F><V><L><P><V><T><M><L><T><A><C><Y><S><L><I><C><H><E><I><C><K><N><L><K><V><K><T><Q><A><W><R><V><G><G><G><G><W><R><T><W><D><R><P><S><P><S><T><L><A><A><T><T><R><G><L><P><S><R><V><S><S><I><N><T><I><S><R><A><K><I><R><T><V><K><M><T><F><V><I><V><L><A><Y><I><A><C><W><A><P><F><F><S><V><Q><M><W><S><V><W><D><K><N><A><P><D><E><D><S><T><N><V><A><F><T><I><S><M><L><L><G><N><L><N><S><C><C><N><P><W><I><Y><M><G><F><N><S><H><L><L><P><R><P><L><R><H><L><A><C><C><G><G><P><Q><P><R><M><R><R><R><L><S><D><G><S><L><S><S><R><H><T><T><L><L><T><R><S><S><C><P><A><T><L><S><L><S><L><S><L><T><L><S><G><R><P><R><P><E><E><S><P><R><D><L><E><L><A><D><G><E><G><T><A><E><T><I><I><F>
(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, may recognize and internalize the complex formed by AVP/Arg-vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through DNM2/dynamin 2-dependent endocytosis.<BOP>
P47901
Q14738
2A5D_HUMAN
PP2A B subunit isoform R5-delta
Homo
<M><P><Y><K><L><K><K><E><K><E><P><P><K><V><A><K><C><T><A><K><P><S><S><S><G><K><D><G><G><G><E><N><T><E><E><A><Q><P><Q><P><Q><P><Q><P><Q><P><Q><A><Q><S><Q><P><P><S><S><N><K><R><P><S><N><S><T><P><P><P><T><Q><L><S><K><I><K><Y><S><G><G><P><Q><I><V><K><K><E><R><R><Q><S><S><S><R><F><N><L><S><K><N><R><E><L><Q><K><L><P><A><L><K><D><S><P><T><Q><E><R><E><E><L><F><I><Q><K><L><R><Q><C><C><V><L><F><D><F><V><S><D><P><L><S><D><L><K><F><K><E><V><K><R><A><G><L><N><E><M><V><E><Y><I><T><H><S><R><D><V><V><T><E><A><I><Y><P><E><A><V><T><M><F><S><V><N><L><F><R><T><L><P><P><S><S><N><P><T><G><A><E><F><D><P><E><E><D><E><P><T><L><E><A><A><W><P><H><L><Q><L><V><Y><E><F><F><L><R><F><L><E><S><P><D><F><Q><P><N><I><A><K><K><Y><I><D><Q><K><F><V><L><A><L><L><D><L><F><D><S><E><D><P><R><E><R><D><F><L><K><T><I><L><H><R><I><Y><G><K><F><L><G><L><R><A><Y><I><R><R><Q><I><N><H><I><F><Y><R><F><I><Y><E><T><E><H><H><N><G><I><A><E><L><L><E><I><L><G><S><I><I><N><G><F><A><L><P><L><K><E><E><H><K><M><F><L><I><R><V><L><L><P><L><H><K><V><K><S><L><S><V><Y><H><P><Q><L><A><Y><C><V><V><Q><F><L><E><K><E><S><S><L><T><E><P><V><I><V><G><L><L><K><F><W><P><K><T><H><S><P><K><E><V><M><F><L><N><E><L><E><E><I><L><D><V><I><E><P><S><E><F><S><K><V><M><E><P><L><F><R><Q><L><A><K><C><V><S><S><P><H><F><Q><V><A><E><R><A><L><Y><Y><W><N><N><E><Y><I><M><S><L><I><S><D><N><A><A><R><V><L><P><I><M><F><P><A><L><Y><R><N><S><K><S><H><W><N><K><T><I><H><G><L><I><Y><N><A><L><K><L><F><M><E><M><N><Q><K><L><F><D><D><C><T><Q><Q><Y><K><A><E><K><Q><K><G><R><F><R><M><K><E><R><E><E><M><W><Q><K><I><E><E><L><A><R><L><N><P><Q><Y><P><M><F><R><A><P><P><P><L><P><P><V><Y><S><M><E><T><E><T><P><T><A><E><D><I><Q><L><L><K><R><T><V><E><T><E><A><V><Q><M><L><K><D><I><K><K><E><K><V><L><L><R><R><K><S><E><L><P><Q><D><V><Y><T><I><K><A><L><E><A><H><K><R><A><E><E><F><L><T><A><S><Q><E><A><L>
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.<BOP>
Q14738
P24539
AT5F1_HUMAN
ATP synthase subunit b
Homo
<M><L><S><R><V><V><L><S><A><A><A><T><A><A><P><S><L><K><N><A><A><F><L><G><P><G><V><L><Q><A><T><R><T><F><H><T><G><Q><P><H><L><V><P><V><P><P><L><P><E><Y><G><G><K><V><R><Y><G><L><I><P><E><E><F><F><Q><F><L><Y><P><K><T><G><V><T><G><P><Y><V><L><G><T><G><L><I><L><Y><A><L><S><K><E><I><Y><V><I><S><A><E><T><F><T><A><L><S><V><L><G><V><M><V><Y><G><I><K><K><Y><G><P><F><V><A><D><F><A><D><K><L><N><E><Q><K><L><A><Q><L><E><E><A><K><Q><A><S><I><Q><H><I><Q><N><A><I><D><T><E><K><S><Q><Q><A><L><V><Q><K><R><H><Y><L><F><D><V><Q><R><N><N><I><A><M><A><L><E><V><T><Y><R><E><R><L><Y><R><V><Y><K><E><V><K><N><R><L><D><Y><H><I><S><V><Q><N><M><M><R><R><K><E><Q><E><H><M><I><N><W><V><E><K><H><V><V><Q><S><I><S><T><Q><Q><E><K><E><T><I><A><K><C><I><A><D><L><K><L><L><A><K><K><A><Q><A><Q><P><V><M>
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.<BOP>
P24539
P11177
ODPB_HUMAN
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Homo
<M><A><A><V><S><G><L><V><R><R><P><L><R><E><V><S><G><L><L><K><R><R><F><H><W><T><A><P><A><A><L><Q><V><T><V><R><D><A><I><N><Q><G><M><D><E><E><L><E><R><D><E><K><V><F><L><L><G><E><E><V><A><Q><Y><D><G><A><Y><K><V><S><R><G><L><W><K><K><Y><G><D><K><R><I><I><D><T><P><I><S><E><M><G><F><A><G><I><A><V><G><A><A><M><A><G><L><R><P><I><C><E><F><M><T><F><N><F><S><M><Q><A><I><D><Q><V><I><N><S><A><A><K><T><Y><Y><M><S><G><G><L><Q><P><V><P><I><V><F><R><G><P><N><G><A><S><A><G><V><A><A><Q><H><S><Q><C><F><A><A><W><Y><G><H><C><P><G><L><K><V><V><S><P><W><N><S><E><D><A><K><G><L><I><K><S><A><I><R><D><N><N><P><V><V><V><L><E><N><E><L><M><Y><G><V><P><F><E><F><P><P><E><A><Q><S><K><D><F><L><I><P><I><G><K><A><K><I><E><R><Q><G><T><H><I><T><V><V><S><H><S><R><P><V><G><H><C><L><E><A><A><A><V><L><S><K><E><G><V><E><C><E><V><I><N><M><R><T><I><R><P><M><D><M><E><T><I><E><A><S><V><M><K><T><N><H><L><V><T><V><E><G><G><W><P><Q><F><G><V><G><A><E><I><C><A><R><I><M><E><G><P><A><F><N><F><L><D><A><P><A><V><R><V><T><G><A><D><V><P><M><P><Y><A><K><I><L><E><D><N><S><I><P><Q><V><K><D><I><I><F><A><I><K><K><T><L><N><I>
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.<BOP>
P11177
Q8NFH3
NUP43_HUMAN
p42
Homo
<M><E><E><I><Y><A><K><F><V><S><Q><K><I><S><K><T><R><W><R><P><L><P><P><G><S><L><Q><T><A><E><T><F><A><T><G><S><W><D><N><E><E><N><Y><I><S><L><W><S><I><G><D><F><G><N><L><D><S><D><G><G><F><E><G><D><H><Q><L><L><C><D><I><R><H><H><G><D><V><M><D><L><Q><F><F><D><Q><E><R><I><V><A><A><S><S><T><G><C><V><T><V><F><L><H><H><P><N><N><Q><T><L><S><V><N><Q><Q><W><T><T><A><H><Y><H><T><G><P><G><S><P><S><Y><S><S><A><P><C><T><G><V><V><C><N><N><P><E><I><V><T><V><G><E><D><G><R><I><N><L><F><R><A><D><H><K><E><A><V><R><T><I><D><N><A><D><S><S><T><L><H><A><V><T><F><L><R><T><P><E><I><L><T><V><N><S><I><G><Q><L><K><I><W><D><F><R><Q><Q><G><N><E><P><S><Q><I><L><S><L><T><G><D><R><V><P><L><H><C><V><D><R><H><P><N><Q><Q><H><V><V><A><T><G><G><Q><D><G><M><L><S><I><W><D><V><R><Q><G><T><M><P><V><S><L><L><K><A><H><E><A><E><M><W><E><V><H><F><H><P><S><N><P><E><H><L><F><T><C><S><E><D><G><S><L><W><H><W><D><A><S><T><D><V><P><E><K><S><S><L><F><H><Q><G><G><R><S><S><T><F><L><S><H><S><I><S><N><Q><A><N><V><H><Q><S><V><I><S><S><W><L><S><T><D><P><A><K><D><R><I><E><I><T><S><L><L><P><S><R><S><L><S><V><N><T><L><D><V><L><G><P><C><L><V><C><G><T><D><A><E><A><I><Y><V><T><R><H><L><F><S>
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.<BOP>
Q8NFH3
O00488
ZN593_HUMAN
Zinc finger protein T86
Homo
<M><G><R><S><R><R><T><G><A><H><R><A><H><S><L><A><R><Q><M><K><A><K><R><R><R><P><D><L><D><E><I><H><R><E><L><R><P><Q><G><S><A><R><P><Q><P><D><P><N><A><E><F><D><P><D><L><P><G><G><G><L><H><R><C><L><A><C><A><R><Y><F><I><D><S><T><N><L><K><T><H><F><R><S><K><D><H><K><K><R><L><K><Q><L><S><V><E><P><Y><S><Q><E><E><A><E><R><A><A><G><M><G><S><Y><V><P><P><R><R><L><A><V><P><T><E><V><S><T><E><V><P><E><M><D><T><S><T>
Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome . Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity .<BOP>
O00488
Q9Y4H4
GPSM3_HUMAN
Protein G18
Homo
<M><E><A><E><R><P><Q><E><E><E><D><G><E><Q><G><P><P><Q><D><E><E><G><W><P><P><P><N><S><T><T><R><P><W><R><S><A><P><P><S><P><P><P><P><G><T><R><H><T><A><L><G><P><R><S><A><S><L><L><S><L><Q><T><E><L><L><L><D><L><V><A><E><A><Q><S><R><R><L><E><E><Q><R><A><T><F><Y><T><P><Q><N><P><S><S><L><A><P><A><P><L><R><P><L><E><D><R><E><Q><L><Y><S><T><I><L><S><H><Q><C><Q><R><M><E><A><Q><R><S><E><P><P><L><P><P><G><G><Q><E><L><L><E><L><L><L><R><V><Q><G><G><G><R><M><E><E><Q><R><S><R><P><P><T><H><T><C>
Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.<BOP>
Q9Y4H4
O75508
CLD11_HUMAN
Oligodendrocyte-specific protein
Homo
<M><V><A><T><C><L><Q><V><V><G><F><V><T><S><F><V><G><W><I><G><V><I><V><T><T><S><T><N><D><W><V><V><T><C><G><Y><T><I><P><T><C><R><K><L><D><E><L><G><S><K><G><L><W><A><D><C><V><M><A><T><G><L><Y><H><C><K><P><L><V><D><I><L><I><L><P><G><Y><V><Q><A><C><R><A><L><M><I><A><A><S><V><L><G><L><P><A><I><L><L><L><L><T><V><L><P><C><I><R><M><G><Q><E><P><G><V><A><K><Y><R><R><A><Q><L><A><G><V><L><L><I><L><L><A><L><C><A><L><V><A><T><I><W><F><P><V><C><A><H><R><E><T><T><I><V><S><F><G><Y><S><L><Y><A><G><W><I><G><A><V><L><C><L><V><G><G><C><V><I><L><C><C><A><G><D><A><Q><A><F><G><E><N><R><F><Y><Y><T><A><G><S><S><S><P><T><H><A><K><S><A><H><V>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
O75508
O95931
CBX7_HUMAN
Chromobox protein homolog 7
Homo
<M><E><L><S><A><I><G><E><Q><V><F><A><V><E><S><I><R><K><K><R><V><R><K><G><K><V><E><Y><L><V><K><W><K><G><W><P><P><K><Y><S><T><W><E><P><E><E><H><I><L><D><P><R><L><V><M><A><Y><E><E><K><E><E><R><D><R><A><S><G><Y><R><K><R><G><P><K><P><K><R><L><L><L><Q><R><L><Y><S><M><D><L><R><S><S><H><K><A><K><G><K><E><K><L><C><F><S><L><T><C><P><L><G><S><G><S><P><E><G><V><V><K><A><G><A><P><E><L><V><D><K><G><P><L><V><P><T><L><P><F><P><L><R><K><P><R><K><A><H><K><Y><L><R><L><S><R><K><K><F><P><P><R><G><P><N><L><E><S><H><S><H><R><R><E><L><F><L><Q><E><P><P><A><P><D><V><L><Q><A><A><G><E><W><E><P><A><A><Q><P><P><E><E><E><A><D><A><D><L><A><E><G><P><P><P><W><T><P><A><L><P><S><S><E><V><T><V><T><D><I><T><A><N><S><I><T><V><T><F><R><E><A><Q><A><A><E><G><F><F><R><D><R><S><G><K><F>
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<BOP>
O95931
Q86YW7
GPHB5_HUMAN
Thyrostimulin subunit beta
Homo
<M><K><L><A><F><L><F><L><G><P><M><A><L><L><L><L><A><G><Y><G><C><V><L><G><A><S><S><G><N><L><R><T><F><V><G><C><A><V><R><E><F><T><F><L><A><K><K><P><G><C><R><G><L><R><I><T><T><D><A><C><W><G><R><C><E><T><W><E><K><P><I><L><E><P><P><Y><I><E><A><H><H><R><V><C><T><Y><N><E><T><K><Q><V><T><V><K><L><P><N><C><A><P><G><V><D><P><F><Y><T><Y><P><V><A><I><R><C><D><C><G><A><C><S><T><A><T><T><E><C><E><T><I>
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.<BOP>
Q86YW7
P27482
CALL3_HUMAN
Calmodulin-related protein NB-1
Homo
<M><A><D><Q><L><T><E><E><Q><V><T><E><F><K><E><A><F><S><L><F><D><K><D><G><D><G><C><I><T><T><R><E><L><G><T><V><M><R><S><L><G><Q><N><P><T><E><A><E><L><R><D><M><M><S><E><I><D><R><D><G><N><G><T><V><D><F><P><E><F><L><G><M><M><A><R><K><M><K><D><T><D><N><E><E><E><I><R><E><A><F><R><V><F><D><K><D><G><N><G><F><V><S><A><A><E><L><R><H><V><M><T><R><L><G><E><K><L><S><D><E><E><V><D><E><M><I><R><A><A><D><T><D><G><D><G><Q><V><N><Y><E><E><F><V><R><V><L><V><S><K>
May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.<BOP>
P27482
Q9Y3D8
KAD6_HUMAN
Dual activity adenylate kinase/ATPase
Homo
<M><L><L><P><N><I><L><L><T><G><T><P><G><V><G><K><T><T><L><G><K><E><L><A><S><K><S><G><L><K><Y><I><N><V><G><D><L><A><R><E><E><Q><L><Y><D><G><Y><D><E><E><Y><D><C><P><I><L><D><E><D><R><V><V><D><E><L><D><N><Q><M><R><E><G><G><V><I><V><D><Y><H><G><C><D><F><F><P><E><R><W><F><H><I><V><F><V><L><R><T><D><T><N><V><L><Y><E><R><L><E><T><R><G><Y><N><E><K><K><L><T><D><N><I><Q><C><E><I><F><Q><V><L><Y><E><E><A><T><A><S><Y><K><E><E><I><V><H><Q><L><P><S><N><K><P><E><E><L><E><N><N><V><D><Q><I><L><K><W><I><E><Q><W><I><K><D><H><N><S>
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.<BOP>
Q9Y3D8
P25105
PTAFR_HUMAN
Platelet-activating factor receptor
Homo
<M><E><P><H><D><S><S><H><M><D><S><E><F><R><Y><T><L><F><P><I><V><Y><S><I><I><F><V><L><G><V><I><A><N><G><Y><V><L><W><V><F><A><R><L><Y><P><C><K><K><F><N><E><I><K><I><F><M><V><N><L><T><M><A><D><M><L><F><L><I><T><L><P><L><W><I><V><Y><Y><Q><N><Q><G><N><W><I><L><P><K><F><L><C><N><V><A><G><C><L><F><F><I><N><T><Y><C><S><V><A><F><L><G><V><I><T><Y><N><R><F><Q><A><V><T><R><P><I><K><T><A><Q><A><N><T><R><K><R><G><I><S><L><S><L><V><I><W><V><A><I><V><G><A><A><S><Y><F><L><I><L><D><S><T><N><T><V><P><D><S><A><G><S><G><N><V><T><R><C><F><E><H><Y><E><K><G><S><V><P><V><L><I><I><H><I><F><I><V><F><S><F><F><L><V><F><L><I><I><L><F><C><N><L><V><I><I><R><T><L><L><M><Q><P><V><Q><Q><Q><R><N><A><E><V><K><R><R><A><L><W><M><V><C><T><V><L><A><V><F><I><I><C><F><V><P><H><H><V><V><Q><L><P><W><T><L><A><E><L><G><F><Q><D><S><K><F><H><Q><A><I><N><D><A><H><Q><V><T><L><C><L><L><S><T><N><C><V><L><D><P><V><I><Y><C><F><L><T><K><K><F><R><K><H><L><T><E><K><F><Y><S><M><R><S><S><R><K><C><S><R><A><T><T><D><T><V><T><E><V><V><V><P><F><N><Q><I><P><G><N><S><L><K><N>
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.<BOP>
P25105
P10145
IL8_HUMAN
IL8/NAP1 form VI
Homo
<M><T><S><K><L><A><V><A><L><L><A><A><F><L><I><S><A><A><L><C><E><G><A><V><L><P><R><S><A><K><E><L><R><C><Q><C><I><K><T><Y><S><K><P><F><H><P><K><F><I><K><E><L><R><V><I><E><S><G><P><H><C><A><N><T><E><I><I><V><K><L><S><D><G><R><E><L><C><L><D><P><K><E><N><W><V><Q><R><V><V><E><K><F><L><K><R><A><E><N><S>
Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection . Also plays an important role in neutrophil activation . Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells . G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways .<BOP>
P10145
P08559
ODPA_HUMAN
PDHE1-A type I
Homo
<M><R><K><M><L><A><A><V><S><R><V><L><S><G><A><S><Q><K><P><A><S><R><V><L><V><A><S><R><N><F><A><N><D><A><T><F><E><I><K><K><C><D><L><H><R><L><E><E><G><P><P><V><T><T><V><L><T><R><E><D><G><L><K><Y><Y><R><M><M><Q><T><V><R><R><M><E><L><K><A><D><Q><L><Y><K><Q><K><I><I><R><G><F><C><H><L><C><D><G><Q><E><A><C><C><V><G><L><E><A><G><I><N><P><T><D><H><L><I><T><A><Y><R><A><H><G><F><T><F><T><R><G><L><S><V><R><E><I><L><A><E><L><T><G><R><K><G><G><C><A><K><G><K><G><G><S><M><H><M><Y><A><K><N><F><Y><G><G><N><G><I><V><G><A><Q><V><P><L><G><A><G><I><A><L><A><C><K><Y><N><G><K><D><E><V><C><L><T><L><Y><G><D><G><A><A><N><Q><G><Q><I><F><E><A><Y><N><M><A><A><L><W><K><L><P><C><I><F><I><C><E><N><N><R><Y><G><M><G><T><S><V><E><R><A><A><A><S><T><D><Y><Y><K><R><G><D><F><I><P><G><L><R><V><D><G><M><D><I><L><C><V><R><E><A><T><R><F><A><A><A><Y><C><R><S><G><K><G><P><I><L><M><E><L><Q><T><Y><R><Y><H><G><H><S><M><S><D><P><G><V><S><Y><R><T><R><E><E><I><Q><E><V><R><S><K><S><D><P><I><M><L><L><K><D><R><M><V><N><S><N><L><A><S><V><E><E><L><K><E><I><D><V><E><V><R><K><E><I><E><D><A><A><Q><F><A><T><A><D><P><E><P><P><L><E><E><L><G><Y><H><I><Y><S><S><D><P><P><F><E><V><R><G><A><N><Q><W><I><K><F><K><S><V><S>
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.<BOP>
P08559
O95997
PTTG1_HUMAN
Pituitary tumor-transforming gene 1 protein
Homo
<M><A><T><L><I><Y><V><D><K><E><N><G><E><P><G><T><R><V><V><A><K><D><G><L><K><L><G><S><G><P><S><I><K><A><L><D><G><R><S><Q><V><S><T><P><R><F><G><K><T><F><D><A><P><P><A><L><P><K><A><T><R><K><A><L><G><T><V><N><R><A><T><E><K><S><V><K><T><K><G><P><L><K><Q><K><Q><P><S><F><S><A><K><K><M><T><E><K><T><V><K><A><K><S><S><V><P><A><S><D><D><A><Y><P><E><I><E><K><F><F><P><F><N><P><L><D><F><E><S><F><D><L><P><E><E><H><Q><I><A><H><L><P><L><S><G><V><P><L><M><I><L><D><E><E><R><E><L><E><K><L><F><Q><L><G><P><P><S><P><V><K><M><P><S><P><P><W><E><S><N><L><L><Q><S><P><S><S><I><L><S><T><L><D><V><E><L><P><P><V><C><C><D><I><D><I>
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.<BOP>
O95997
Q504Y3
ZCPW2_HUMAN
Zinc finger CW-type PWWP domain protein 2
Homo
<M><D><K><E><K><L><D><V><K><I><E><Y><C><N><Y><A><M><D><S><S><V><E><N><M><Y><V><N><K><V><W><V><Q><C><E><N><E><N><C><L><K><W><R><L><L><S><S><E><D><S><A><K><V><D><H><D><E><P><W><Y><C><F><M><N><T><D><S><R><Y><N><N><C><S><I><S><E><E><D><F><P><E><E><S><Q><L><H><Q><C><G><F><K><I><V><Y><S><Q><L><P><L><G><S><L><V><L><V><K><L><Q><N><W><P><S><W><P><G><I><L><C><P><D><R><F><K><G><K><Y><V><T><Y><D><P><D><G><N><V><E><E><Y><H><I><E><F><L><G><D><P><H><S><R><S><W><I><K><A><T><F><V><G><H><Y><S><I><T><L><K><P><E><K><C><K><N><K><K><K><W><Y><K><S><A><L><Q><E><A><C><L><L><Y><G><Y><S><H><E><Q><R><L><E><M><C><C><L><S><K><L><Q><D><K><S><E><T><H><D><K><V><A><A><L><V><K><K><R><K><Q><T><S><K><N><N><I><E><K><K><K><P><K><F><R><K><R><K><R><K><A><I><L><K><C><S><F><E><N><V><Y><S><D><D><A><L><S><K><E><N><R><V><V><C><E><T><E><V><L><L><K><E><L><E><Q><M><L><Q><Q><A><L><Q><P><T><A><T><P><D><E><S><E><E><G><H><G><E><E><I><N><M><G><E><K><L><S><K><C><S><P><E><A><P><A><G><S><L><F><E><N><H><Y><E><E><D><Y><L><V><I><D><G><I><K><L><K><A><G><E><C><I><E><D><I><T><N><K><F><K><E><I><D><A><L><M><S><E><F>
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 . The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 .<BOP>
Q504Y3
Q9UBV7
B4GT7_HUMAN
Xylosylprotein beta-1,4-galactosyltransferase
Homo
<M><F><P><S><R><R><K><A><A><Q><L><P><W><E><D><G><R><S><G><L><L><S><G><G><L><P><R><K><C><S><V><F><H><L><F><V><A><C><L><S><L><G><F><F><S><L><L><W><L><Q><L><S><C><S><G><D><V><A><R><A><V><R><G><Q><G><Q><E><T><S><G><P><P><R><A><C><P><P><E><P><P><P><E><H><W><E><E><D><A><S><W><G><P><H><R><L><A><V><L><V><P><F><R><E><R><F><E><E><L><L><V><F><V><P><H><M><R><R><F><L><S><R><K><K><I><R><H><H><I><Y><V><L><N><Q><V><D><H><F><R><F><N><R><A><A><L><I><N><V><G><F><L><E><S><S><N><S><T><D><Y><I><A><M><H><D><V><D><L><L><P><L><N><E><E><L><D><Y><G><F><P><E><A><G><P><F><H><V><A><S><P><E><L><H><P><L><Y><H><Y><K><T><Y><V><G><G><I><L><L><L><S><K><Q><H><Y><R><L><C><N><G><M><S><N><R><F><W><G><W><G><R><E><D><D><E><F><Y><R><R><I><K><G><A><G><L><Q><L><F><R><P><S><G><I><T><T><G><Y><K><T><F><R><H><L><H><D><P><A><W><R><K><R><D><Q><K><R><I><A><A><Q><K><Q><E><Q><F><K><V><D><R><E><G><G><L><N><T><V><K><Y><H><V><A><S><R><T><A><L><S><V><G><G><A><P><C><T><V><L><N><I><M><L><D><C><D><K><T><A><T><P><W><C><T><F><S>
Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.<BOP>
Q9UBV7
Q13261
I15RA_HUMAN
Soluble interleukin-15 receptor subunit alpha
Homo
<M><A><P><R><R><A><R><G><C><R><T><L><G><L><P><A><L><L><L><L><L><L><L><R><P><P><A><T><R><G><I><T><C><P><P><P><M><S><V><E><H><A><D><I><W><V><K><S><Y><S><L><Y><S><R><E><R><Y><I><C><N><S><G><F><K><R><K><A><G><T><S><S><L><T><E><C><V><L><N><K><A><T><N><V><A><H><W><T><T><P><S><L><K><C><I><R><D><P><A><L><V><H><Q><R><P><A><P><P><S><T><V><T><T><A><G><V><T><P><Q><P><E><S><L><S><P><S><G><K><E><P><A><A><S><S><P><S><S><N><N><T><A><A><T><T><A><A><I><V><P><G><S><Q><L><M><P><S><K><S><P><S><T><G><T><T><E><I><S><S><H><E><S><S><H><G><T><P><S><Q><T><T><A><K><N><W><E><L><T><A><S><A><S><H><Q><P><P><G><V><Y><P><Q><G><H><S><D><T><T><V><A><I><S><T><S><T><V><L><L><C><G><L><S><A><V><S><L><L><A><C><Y><L><K><S><R><Q><T><P><P><L><A><S><V><E><M><E><A><M><E><A><L><P><V><T><W><G><T><S><S><R><D><E><D><L><E><N><C><S><H><H><L>
Does not bind IL15.<BOP>
Q13261
O75909
CCNK_HUMAN
Cyclin-K
Homo
<M><K><E><N><K><E><N><S><S><P><S><V><T><S><A><N><L><D><H><T><K><P><C><W><Y><W><D><K><K><D><L><A><H><T><P><S><Q><L><E><G><L><D><P><A><T><E><A><R><Y><R><R><E><G><A><R><F><I><F><D><V><G><T><R><L><G><L><H><Y><D><T><L><A><T><G><I><I><Y><F><H><R><F><Y><M><F><H><S><F><K><Q><F><P><R><Y><V><T><G><A><C><C><L><F><L><A><G><K><V><E><E><T><P><K><K><C><K><D><I><I><K><T><A><R><S><L><L><N><D><V><Q><F><G><Q><F><G><D><D><P><K><E><E><V><M><V><L><E><R><I><L><L><Q><T><I><K><F><D><L><Q><V><E><H><P><Y><Q><F><L><L><K><Y><A><K><Q><L><K><G><D><K><N><K><I><Q><K><L><V><Q><M><A><W><T><F><V><N><D><S><L><C><T><T><L><S><L><Q><W><E><P><E><I><I><A><V><A><V><M><Y><L><A><G><R><L><C><K><F><E><I><Q><E><W><T><S><K><P><M><Y><R><R><W><W><E><Q><F><V><Q><D><V><P><V><D><V><L><E><D><I><C><H><Q><I><L><D><L><Y><S><Q><G><K><Q><Q><M><P><H><H><T><P><H><Q><L><Q><Q><P><P><S><L><Q><P><T><P><Q><V><P><Q><V><Q><Q><S><Q><P><S><Q><S><S><E><P><S><Q><P><Q><Q><K><D><P><Q><Q><P><A><Q><Q><Q><Q><P><A><Q><Q><P><K><K><P><S><P><Q><P><S><S><P><R><Q><V><K><R><A><V><V><V><S><P><K><E><E><N><K><A><A><E><P><P><P><P><K><I><P><K><I><E><T><T><H><P><P><L><P><P><A><H><P><P><P><D><R><K><P><P><L><A><A><A><L><G><E><A><E><P><P><G><P><V><D><A><T><D><L><P><K><V><Q><I><P><P><P><A><H><P><A><P><V><H><Q><P><P><P><L><P><H><R><P><P><P><P><P><P><S><S><Y><M><T><G><M><S><T><T><S><S><Y><M><S><G><E><G><Y><Q><S><L><Q><S><M><M><K><T><E><G><P><S><Y><G><A><L><P><P><A><Y><G><P><P><A><H><L><P><Y><H><P><H><V><Y><P><P><N><P><P><P><P><P><V><P><P><P><P><A><S><F><P><P><P><A><I><P><P><P><T><P><G><Y><P><P><P><P><P><T><Y><N><P><N><F><P><P><P><P><P><R><L><P><P><T><H><A><V><P><P><H><P><P><P><G><L><G><L><P><P><A><S><Y><P><P><P><A><V><P><P><G><G><Q><P><P><V><P><P><P><I><P><P><P><G><M><P><P><V><G><G><L><G><R><A><A><W><M><R>
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).<BOP>
O75909
P52434
RPAB3_HUMAN
RPB8 homolog
Homo
<M><A><G><I><L><F><E><D><I><F><D><V><K><D><I><D><P><E><G><K><K><F><D><R><V><S><R><L><H><C><E><S><E><S><F><K><M><D><L><I><L><D><V><N><I><Q><I><Y><P><V><D><L><G><D><K><F><R><L><V><I><A><S><T><L><Y><E><D><G><T><L><D><D><G><E><Y><N><P><T><D><D><R><P><S><R><A><D><Q><F><E><Y><V><M><Y><G><K><V><Y><R><I><E><G><D><E><T><S><T><E><A><A><T><R><L><S><A><Y><V><S><Y><G><G><L><L><M><R><L><Q><G><D><A><N><N><L><H><G><F><E><V><D><S><R><V><Y><L><L><M><K><K><L><A><F>
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.<BOP>
P52434
Q13309
SKP2_HUMAN
p45skp2
Homo
<M><H><R><K><H><L><Q><E><I><P><D><L><S><S><N><V><A><T><S><F><T><W><G><W><D><S><S><K><T><S><E><L><L><S><G><M><G><V><S><A><L><E><K><E><E><P><D><S><E><N><I><P><Q><E><L><L><S><N><L><G><H><P><E><S><P><P><R><K><R><L><K><S><K><G><S><D><K><D><F><V><I><V><R><R><P><K><L><N><R><E><N><F><P><G><V><S><W><D><S><L><P><D><E><L><L><L><G><I><F><S><C><L><C><L><P><E><L><L><K><V><S><G><V><C><K><R><W><Y><R><L><A><S><D><E><S><L><W><Q><T><L><D><L><T><G><K><N><L><H><P><D><V><T><G><R><L><L><S><Q><G><V><I><A><F><R><C><P><R><S><F><M><D><Q><P><L><A><E><H><F><S><P><F><R><V><Q><H><M><D><L><S><N><S><V><I><E><V><S><T><L><H><G><I><L><S><Q><C><S><K><L><Q><N><L><S><L><E><G><L><R><L><S><D><P><I><V><N><T><L><A><K><N><S><N><L><V><R><L><N><L><S><G><C><S><G><F><S><E><F><A><L><Q><T><L><L><S><S><C><S><R><L><D><E><L><N><L><S><W><C><F><D><F><T><E><K><H><V><Q><V><A><V><A><H><V><S><E><T><I><T><Q><L><N><L><S><G><Y><R><K><N><L><Q><K><S><D><L><S><T><L><V><R><R><C><P><N><L><V><H><L><D><L><S><D><S><V><M><L><K><N><D><C><F><Q><E><F><F><Q><L><N><Y><L><Q><H><L><S><L><S><R><C><Y><D><I><I><P><E><T><L><L><E><L><G><E><I><P><T><L><K><T><L><Q><V><F><G><I><V><P><D><G><T><L><Q><L><L><K><E><A><L><P><H><L><Q><I><N><C><S><H><F><T><T><I><A><R><P><T><I><G><N><K><K><N><Q><E><I><W><G><I><K><C><R><L><T><L><Q><K><P><S><C><L>
Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.<BOP>
Q13309
P17213
BPI_HUMAN
CAP 57
Homo
<M><R><E><N><M><A><R><G><P><C><N><A><P><R><W><A><S><L><M><V><L><V><A><I><G><T><A><V><T><A><A><V><N><P><G><V><V><V><R><I><S><Q><K><G><L><D><Y><A><S><Q><Q><G><T><A><A><L><Q><K><E><L><K><R><I><K><I><P><D><Y><S><D><S><F><K><I><K><H><L><G><K><G><H><Y><S><F><Y><S><M><D><I><R><E><F><Q><L><P><S><S><Q><I><S><M><V><P><N><V><G><L><K><F><S><I><S><N><A><N><I><K><I><S><G><K><W><K><A><Q><K><R><F><L><K><M><S><G><N><F><D><L><S><I><E><G><M><S><I><S><A><D><L><K><L><G><S><N><P><T><S><G><K><P><T><I><T><C><S><S><C><S><S><H><I><N><S><V><H><V><H><I><S><K><S><K><V><G><W><L><I><Q><L><F><H><K><K><I><E><S><A><L><R><N><K><M><N><S><Q><V><C><E><K><V><T><N><S><V><S><S><E><L><Q><P><Y><F><Q><T><L><P><V><M><T><K><I><D><S><V><A><G><I><N><Y><G><L><V><A><P><P><A><T><T><A><E><T><L><D><V><Q><M><K><G><E><F><Y><S><E><N><H><H><N><P><P><P><F><A><P><P><V><M><E><F><P><A><A><H><D><R><M><V><Y><L><G><L><S><D><Y><F><F><N><T><A><G><L><V><Y><Q><E><A><G><V><L><K><M><T><L><R><D><D><M><I><P><K><E><S><K><F><R><L><T><T><K><F><F><G><T><F><L><P><E><V><A><K><K><F><P><N><M><K><I><Q><I><H><V><S><A><S><T><P><P><H><L><S><V><Q><P><T><G><L><T><F><Y><P><A><V><D><V><Q><A><F><A><V><L><P><N><S><S><L><A><S><L><F><L><I><G><M><H><T><T><G><S><M><E><V><S><A><E><S><N><R><L><V><G><E><L><K><L><D><R><L><L><L><E><L><K><H><S><N><I><G><P><F><P><V><E><L><L><Q><D><I><M><N><Y><I><V><P><I><L><V><L><P><R><V><N><E><K><L><Q><K><G><F><P><L><P><T><P><A><R><V><Q><L><Y><N><V><V><L><Q><P><H><Q><N><F><L><L><F><G><A><D><V><V><Y><K>
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.<BOP>
P17213
Q8WWY3
PRP31_HUMAN
U4/U6 snRNP 61 kDa protein
Homo
<M><S><L><A><D><E><L><L><A><D><L><E><E><A><A><E><E><E><E><G><G><S><Y><G><E><E><E><E><E><P><A><I><E><D><V><Q><E><E><T><Q><L><D><L><S><G><D><S><V><K><T><I><A><K><L><W><D><S><K><M><F><A><E><I><M><M><K><I><E><E><Y><I><S><K><Q><A><K><A><S><E><V><M><G><P><V><E><A><A><P><E><Y><R><V><I><V><D><A><N><N><L><T><V><E><I><E><N><E><L><N><I><I><H><K><F><I><R><D><K><Y><S><K><R><F><P><E><L><E><S><L><V><P><N><A><L><D><Y><I><R><T><V><K><E><L><G><N><S><L><D><K><C><K><N><N><E><N><L><Q><Q><I><L><T><N><A><T><I><M><V><V><S><V><T><A><S><T><T><Q><G><Q><Q><L><S><E><E><E><L><E><R><L><E><E><A><C><D><M><A><L><E><L><N><A><S><K><H><R><I><Y><E><Y><V><E><S><R><M><S><F><I><A><P><N><L><S><I><I><I><G><A><S><T><A><A><K><I><M><G><V><A><G><G><L><T><N><L><S><K><M><P><A><C><N><I><M><L><L><G><A><Q><R><K><T><L><S><G><F><S><S><T><S><V><L><P><H><T><G><Y><I><Y><H><S><D><I><V><Q><S><L><P><P><D><L><R><R><K><A><A><R><L><V><A><A><K><C><T><L><A><A><R><V><D><S><F><H><E><S><T><E><G><K><V><G><Y><E><L><K><D><E><I><E><R><K><F><D><K><W><Q><E><P><P><P><V><K><Q><V><K><P><L><P><A><P><L><D><G><Q><R><K><K><R><G><G><R><R><Y><R><K><M><K><E><R><L><G><L><T><E><I><R><K><Q><A><N><R><M><S><F><G><E><I><E><E><D><A><Y><Q><E><D><L><G><F><S><L><G><H><L><G><K><S><G><S><G><R><V><R><Q><T><Q><V><N><E><A><T><K><A><R><I><S><K><T><L><Q><R><T><L><Q><K><Q><S><V><V><Y><G><G><K><S><T><I><R><D><R><S><S><G><T><A><S><S><V><A><F><T><P><L><Q><G><L><E><I><V><N><P><Q><A><A><E><K><K><V><A><E><A><N><Q><K><Y><F><S><S><M><A><E><F><L><K><V><K><G><E><K><S><G><L><M><S><T>
Involved in pre-mRNA splicing as component of the spliceosome . Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome .<BOP>
Q8WWY3
Q8NGS6
O13C3_HUMAN
Olfactory receptor OR9-8
Homo
<M><I><V><Q><L><I><C><T><V><C><F><L><A><V><N><T><F><H><V><R><S><S><F><D><F><L><K><A><D><D><M><G><E><I><N><Q><T><L><V><S><E><F><L><L><L><G><L><S><G><Y><P><K><I><E><I><V><Y><F><A><L><I><L><V><M><Y><L><V><I><L><I><G><N><G><V><L><I><I><A><S><I><F><D><S><H><F><H><T><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><S><S><S><V><P><S><T><L><V><S><L><I><S><K><K><R><N><I><S><F><S><G><C><A><V><Q><M><F><F><G><F><A><M><G><S><T><E><C><L><L><L><G><M><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><P><I><I><L><S><K><V><A><Y><V><L><M><A><S><V><S><W><L><S><G><G><I><N><S><A><V><Q><T><L><L><A><M><R><L><P><F><C><G><N><N><I><I><N><H><F><A><C><E><I><L><A><V><L><K><L><A><C><A><D><I><S><L><N><I><I><T><M><V><I><S><N><M><A><F><L><V><L><P><L><M><V><I><F><F><S><Y><M><F><I><L><Y><T><I><L><Q><M><N><S><A><T><G><R><R><K><A><F><S><T><C><S><A><H><L><T><V><V><I><I><F><Y><G><T><I><F><F><M><Y><A><K><P><K><S><Q><D><L><I><G><E><E><K><L><Q><A><L><D><K><L><I><S><L><F><Y><G><V><V><T><P><M><L><N><P><I><L><Y><S><L><R><N><K><D><V><K><A><A><V><K><Y><L><L><N><K><K><P><I><H>
Odorant receptor.<BOP>
Q8NGS6
Q6ZSB9
ZBT49_HUMAN
Zinc finger protein 509
Homo
<M><D><P><V><A><T><H><S><C><H><L><L><Q><Q><L><H><E><Q><R><I><Q><G><L><L><C><D><C><M><L><V><V><K><G><V><C><F><K><A><H><K><N><V><L><A><A><F><S><Q><Y><F><R><S><L><F><Q><N><S><S><S><Q><K><N><D><V><F><H><L><D><V><K><N><V><S><G><I><G><Q><I><L><D><F><M><Y><T><S><H><L><D><L><N><Q><D><N><I><Q><V><M><L><D><T><A><Q><C><L><Q><V><Q><N><V><L><S><L><C><H><T><F><L><K><S><A><T><V><V><Q><P><P><G><M><P><C><N><S><T><L><S><L><Q><S><T><L><T><P><D><A><T><C><V><I><S><E><N><Y><P><P><H><L><L><Q><E><C><S><A><D><A><Q><Q><N><K><T><L><D><E><S><H><P><H><A><S><P><S><V><N><R><H><H><S><A><G><E><I><S><K><Q><A><P><D><T><S><D><G><S><C><T><E><L><P><F><K><Q><P><N><Y><Y><Y><K><L><R><N><F><Y><S><K><Q><Y><H><K><H><A><A><G><P><S><Q><E><R><V><V><E><Q><P><F><A><F><S><T><S><T><D><L><T><T><V><E><S><Q><P><C><A><V><S><H><S><E><C><I><L><E><S><P><E><H><L><P><S><N><F><L><A><Q><P><V><N><D><S><A><P><H><P><E><S><D><A><T><C><Q><Q><P><V><K><Q><M><R><L><K><K><A><I><H><L><K><K><L><N><F><L><K><S><Q><K><Y><A><E><Q><V><S><E><P><K><S><D><D><G><L><T><K><R><L><E><S><A><S><K><N><T><L><E><K><A><S><S><Q><S><A><E><E><K><E><S><E><E><V><V><S><C><E><N><F><N><C><I><S><E><T><E><R><P><E><D><P><A><A><L><E><D><Q><S><Q><T><L><Q><S><Q><R><Q><Y><A><C><E><L><C><G><K><P><F><K><H><P><S><N><L><E><L><H><K><R><S><H><T><G><E><K><P><F><E><C><N><I><C><G><K><H><F><S><Q><A><G><N><L><Q><T><H><L><R><R><H><S><G><E><K><P><Y><I><C><E><I><C><G><K><R><F><A><A><S><G><D><V><Q><R><H><I><I><I><H><S><G><E><K><P><H><L><C><D><I><C><G><R><G><F><S><N><F><S><N><L><K><E><H><K><K><T><H><T><A><D><K><V><F><T><C><D><E><C><G><K><S><F><N><M><Q><R><K><L><V><K><H><R><I><R><H><T><G><E><R><P><Y><S><C><S><A><C><G><K><C><F><G><G><S><G><D><L><R><R><H><V><R><T><H><T><G><E><K><P><Y><T><C><E><I><C><N><K><C><F><T><R><S><A><V><L><R><R><H><K><K><M><H><C><K><A><G><D><E><S><P><D><V><L><E><E><L><S><Q><A><I><E><T><S><D><L><E><K><S><Q><S><S><D><S><F><S><Q><D><T><S><V><T><L><M><P><V><S><V><K><L><P><V><H><P><V><E><N><S><V><A><E><F><D><S><H><S><G><G><S><Y><C><K><L><R><S><M><I><Q><P><H><G><V><S><D><Q><E><K><L><S><L><D><P><G><K><L><A><K><P><Q><M><Q><Q><T><Q><P><Q><A><Y><A><Y><S><D><V><D><T><P><A><G><G><E><P><L><Q><A><D><G><M><A><M><I><R><S><S><L><A><A><L><D><N><H><G><G><D><P><L><G><S><R><A><S><S><T><T><Y><R><N><S><E><G><Q><F><F><S><S><M><T><L><W><G><L><A><M><K><T><L><Q><N><E><N><E><L><D><Q>
Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.<BOP>
Q6ZSB9
Q719H9
KCTD1_HUMAN
Potassium channel tetramerization domain-containing protein 1
Homo
<M><S><R><P><L><I><T><R><S><P><A><S><P><L><N><N><Q><G><I><P><T><P><A><Q><L><T><K><S><N><A><P><V><H><I><D><V><G><G><H><M><Y><T><S><S><L><A><T><L><T><K><Y><P><E><S><R><I><G><R><L><F><D><G><T><E><P><I><V><L><D><S><L><K><Q><H><Y><F><I><D><R><D><G><Q><M><F><R><Y><I><L><N><F><L><R><T><S><K><L><L><I><P><D><D><F><K><D><Y><T><L><L><Y><E><E><A><K><Y><F><Q><L><Q><P><M><L><L><E><M><E><R><W><K><Q><D><R><E><T><G><R><F><S><R><P><C><E><C><L><V><V><R><V><A><P><D><L><G><E><R><I><T><L><S><G><D><K><S><L><I><E><E><V><F><P><E><I><G><D><V><M><C><N><S><V><N><A><G><W><N><H><D><S><T><H><V><I><R><F><P><L><N><G><Y><C><H><L><N><S><V><Q><V><L><E><R><L><Q><Q><R><G><F><E><I><V><G><S><C><G><G><G><V><D><S><S><Q><F><S><E><Y><V><L><R><R><E><L><R><R><T><P><R><V><P><S><V><I><R><I><K><Q><E><P><L><D>
May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.<BOP>
Q719H9
P01703
LV140_HUMAN
Ig lambda chain V-I region NEWM
Homo
<M><A><W><S><P><L><L><L><T><L><L><A><H><C><T><G><S><W><A><Q><S><V><L><T><Q><P><P><S><V><S><G><A><P><G><Q><R><V><T><I><S><C><T><G><S><S><S><N><I><G><A><G><Y><D><V><H><W><Y><Q><Q><L><P><G><T><A><P><K><L><L><I><Y><G><N><S><N><R><P><S><G><V><P><D><R><F><S><G><S><K><S><G><T><S><A><S><L><A><I><T><G><L><Q><A><E><D><E><A><D><Y><Y><C><Q><S><Y><D><S><S><L><S><G>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01703
P02771
FETA_HUMAN
Alpha-fetoglobulin
Homo
<M><K><W><V><E><S><I><F><L><I><F><L><L><N><F><T><E><S><R><T><L><H><R><N><E><Y><G><I><A><S><I><L><D><S><Y><Q><C><T><A><E><I><S><L><A><D><L><A><T><I><F><F><A><Q><F><V><Q><E><A><T><Y><K><E><V><S><K><M><V><K><D><A><L><T><A><I><E><K><P><T><G><D><E><Q><S><S><G><C><L><E><N><Q><L><P><A><F><L><E><E><L><C><H><E><K><E><I><L><E><K><Y><G><H><S><D><C><C><S><Q><S><E><E><G><R><H><N><C><F><L><A><H><K><K><P><T><P><A><S><I><P><L><F><Q><V><P><E><P><V><T><S><C><E><A><Y><E><E><D><R><E><T><F><M><N><K><F><I><Y><E><I><A><R><R><H><P><F><L><Y><A><P><T><I><L><L><W><A><A><R><Y><D><K><I><I><P><S><C><C><K><A><E><N><A><V><E><C><F><Q><T><K><A><A><T><V><T><K><E><L><R><E><S><S><L><L><N><Q><H><A><C><A><V><M><K><N><F><G><T><R><T><F><Q><A><I><T><V><T><K><L><S><Q><K><F><T><K><V><N><F><T><E><I><Q><K><L><V><L><D><V><A><H><V><H><E><H><C><C><R><G><D><V><L><D><C><L><Q><D><G><E><K><I><M><S><Y><I><C><S><Q><Q><D><T><L><S><N><K><I><T><E><C><C><K><L><T><T><L><E><R><G><Q><C><I><I><H><A><E><N><D><E><K><P><E><G><L><S><P><N><L><N><R><F><L><G><D><R><D><F><N><Q><F><S><S><G><E><K><N><I><F><L><A><S><F><V><H><E><Y><S><R><R><H><P><Q><L><A><V><S><V><I><L><R><V><A><K><G><Y><Q><E><L><L><E><K><C><F><Q><T><E><N><P><L><E><C><Q><D><K><G><E><E><E><L><Q><K><Y><I><Q><E><S><Q><A><L><A><K><R><S><C><G><L><F><Q><K><L><G><E><Y><Y><L><Q><N><A><F><L><V><A><Y><T><K><K><A><P><Q><L><T><S><S><E><L><M><A><I><T><R><K><M><A><A><T><A><A><T><C><C><Q><L><S><E><D><K><L><L><A><C><G><E><G><A><A><D><I><I><I><G><H><L><C><I><R><H><E><M><T><P><V><N><P><G><V><G><Q><C><C><T><S><S><Y><A><N><R><R><P><C><F><S><S><L><V><V><D><E><T><Y><V><P><P><A><F><S><D><D><K><F><I><F><H><K><D><L><C><Q><A><Q><G><V><A><L><Q><T><M><K><Q><E><F><L><I><N><L><V><K><Q><K><P><Q><I><T><E><E><Q><L><E><A><V><I><A><D><F><S><G><L><L><E><K><C><C><Q><G><Q><E><Q><E><V><C><F><A><E><E><G><Q><K><L><I><S><K><T><R><A><A><L><G><V>
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.<BOP>
P02771
Q9Y6M9
NDUB9_HUMAN
NADH-ubiquinone oxidoreductase B22 subunit
Homo
<M><A><F><L><A><S><G><P><Y><L><T><H><Q><Q><K><V><L><R><L><Y><K><R><A><L><R><H><L><E><S><W><C><V><Q><R><D><K><Y><R><Y><F><A><C><L><M><R><A><R><F><E><E><H><K><N><E><K><D><M><A><K><A><T><Q><L><L><K><E><A><E><E><E><F><W><Y><R><Q><H><P><Q><P><Y><I><F><P><D><S><P><G><G><T><S><Y><E><R><Y><D><C><Y><K><V><P><E><W><C><L><D><D><W><H><P><S><E><K><A><M><Y><P><D><Y><F><A><K><R><E><Q><W><K><K><L><R><R><E><S><W><E><R><E><V><K><Q><L><Q><E><E><T><P><P><G><G><P><L><T><E><A><L><P><P><A><R><K><E><G><D><L><P><P><L><W><W><Y><I><V><T><R><P><R><E><R><P><M>
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.<BOP>
Q9Y6M9
O75373
ZN737_HUMAN
Zinc finger protein 102
Homo
<M><G><P><L><Q><F><R><D><V><A><I><E><F><S><L><E><E><W><H><C><L><D><T><A><Q><R><N><L><Y><R><N><V><M><L><E><N><Y><R><N><L><V><F><L><G><I><V><V><S><K><P><D><L><I><T><C><L><E><Q><G><K><K><P><L><T><M><K><K><H><E><M><V><A><N><P><S><V><T><C><S><H><F><A><R><D><L><W><P><E><Q><S><I><K><D><S><F><Q><K><V><T><L><R><R><Y><E><N><Y><G><H><D><N><L><Q><F><K><K><G><C><E><S><V><D><E><C><K><V><H><K><R><G><Y><N><G><L><N><Q><Y><L><T><T><T><Q><S><K><I><F><Q><C><D><K><Y><V><K><V><I><H><K><F><S><N><S><N><R><H><K><I><R><H><T><G><K><K><P><F><K><C><I><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><K><K><I><H><T><G><E><K><P><F><K><C><E><E><C><G><K><A><F><N><W><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><R><Y><K><C><E><D><C><G><K><A><F><S><R><F><S><Y><L><T><A><H><K><I><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><N><L><T><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><R><S><S><I><L><T><A><H><K><I><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><H><P><S><V><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><R><A><F><K><Y><F><S><S><L><T><T><H><K><I><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><W><S><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><E><A><F><K><Y><S><S><S><L><T><T><H><K><I><I><H><T><G><Q><Q><P><F><K><C><E><E><C><G><K><A><F><K><C><F><S><I><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><S><S><S><H><L><T><A><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><R><C><G><K><A><F><K><R><S><F><I><L><T><R><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><K><C><P><S><T><L><T><T><H><K><V><I><H><T><G><E><K><L>
May be involved in transcriptional regulation.<BOP>
O75373
Q9BS40
LXN_HUMAN
Tissue carboxypeptidase inhibitor
Homo
<M><E><I><P><P><T><N><Y><P><A><S><R><A><A><L><V><A><Q><N><Y><I><N><Y><Q><Q><G><T><P><H><R><V><F><E><V><Q><K><V><K><Q><A><S><M><E><D><I><P><G><R><G><H><K><Y><H><L><K><F><A><V><E><E><I><I><Q><K><Q><V><K><V><N><C><T><A><E><V><L><Y><P><S><T><G><Q><E><T><A><P><E><V><N><F><T><F><E><G><E><T><G><K><N><P><D><E><E><D><N><T><F><Y><Q><R><L><K><S><M><K><E><P><L><E><A><Q><N><I><P><D><N><F><G><N><V><S><P><E><M><T><L><V><L><H><L><A><W><V><A><C><G><Y><I><I><W><Q><N><S><T><E><D><T><W><Y><K><M><V><K><I><Q><T><V><K><Q><V><Q><R><N><D><D><F><I><E><L><D><Y><T><I><L><L><H><N><I><A><S><Q><E><I><I><P><W><Q><M><Q><V><L><W><H><P><Q><Y><G><T><K><V><K><H><N><S><R><L><P><K><E><V><Q><L><E>
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.<BOP>
Q9BS40
Q8NGC3
O10G2_HUMAN
Olfactory receptor 10G2
Homo
<M><G><K><T><K><N><T><S><L><D><A><V><V><T><D><F><I><L><L><G><L><S><H><P><P><N><L><R><S><L><L><F><L><V><F><F><I><I><Y><I><L><T><Q><L><G><N><L><L><I><L><L><T><M><W><A><D><P><K><L><C><A><R><P><M><Y><I><L><L><G><V><L><S><F><L><D><M><W><L><S><S><V><T><V><P><L><L><I><L><D><F><T><P><S><I><K><A><I><P><F><G><G><C><V><A><Q><L><Y><F><F><H><F><L><G><S><T><Q><C><F><L><Y><T><L><M><A><Y><D><R><Y><L><A><I><C><Q><P><L><R><Y><P><V><L><M><N><G><R><L><C><T><V><L><V><A><G><A><W><V><A><G><S><M><H><G><S><I><Q><A><T><L><T><F><R><L><P><Y><C><G><P><N><Q><V><D><Y><F><I><C><D><I><P><A><V><L><R><L><A><C><A><D><T><T><V><N><E><L><V><T><F><V><D><V><G><V><V><A><A><S><C><F><M><L><I><L><L><S><Y><A><N><I><V><N><A><I><L><K><I><R><T><T><D><G><R><R><R><A><F><S><T><C><G><S><H><L><I><V><V><T><V><Y><Y><V><P><C><I><F><I><Y><L><R><A><G><S><K><D><P><L><D><G><A><A><A><V><F><Y><T><V><V><T><P><L><L><N><P><L><I><Y><T><L><R><N><Q><E><V><K><S><A><L><K><R><I><T><A><G>
Odorant receptor.<BOP>
Q8NGC3
O75688
PPM1B_HUMAN
Protein phosphatase 2C isoform beta
Homo
<M><G><A><F><L><D><K><P><K><T><E><K><H><N><A><H><G><A><G><N><G><L><R><Y><G><L><S><S><M><Q><G><W><R><V><E><M><E><D><A><H><T><A><V><V><G><I><P><H><G><L><E><D><W><S><F><F><A><V><Y><D><G><H><A><G><S><R><V><A><N><Y><C><S><T><H><L><L><E><H><I><T><T><N><E><D><F><R><A><A><G><K><S><G><S><A><L><E><L><S><V><E><N><V><K><N><G><I><R><T><G><F><L><K><I><D><E><Y><M><R><N><F><S><D><L><R><N><G><M><D><R><S><G><S><T><A><V><G><V><M><I><S><P><K><H><I><Y><F><I><N><C><G><D><S><R><A><V><L><Y><R><N><G><Q><V><C><F><S><T><Q><D><H><K><P><C><N><P><R><E><K><E><R><I><Q><N><A><G><G><S><V><M><I><Q><R><V><N><G><S><L><A><V><S><R><A><L><G><D><Y><D><Y><K><C><V><D><G><K><G><P><T><E><Q><L><V><S><P><E><P><E><V><Y><E><I><L><R><A><E><E><D><E><F><I><I><L><A><C><D><G><I><W><D><V><M><S><N><E><E><L><C><E><Y><V><K><S><R><L><E><V><S><D><D><L><E><N><V><C><N><W><V><V><D><T><C><L><H><K><G><S><R><D><N><M><S><I><V><L><V><C><F><S><N><A><P><K><V><S><D><E><A><V><K><K><D><S><E><L><D><K><H><L><E><S><R><V><E><E><I><M><E><K><S><G><E><E><G><M><P><D><L><A><H><V><M><R><I><L><S><A><E><N><I><P><N><L><P><P><G><G><G><L><A><G><K><R><N><V><I><E><A><V><Y><S><R><L><N><P><H><R><E><S><D><G><A><S><D><E><A><E><E><S><G><S><Q><G><K><L><V><E><A><L><R><Q><M><R><I><N><H><R><G><N><Y><R><Q><L><L><E><E><M><L><T><S><Y><R><L><A><K><V><E><G><E><E><S><P><A><E><P><A><A><T><A><T><S><S><N><S><D><A><G><N><P><V><T><M><Q><E><S><H><T><E><S><E><S><G><L><A><E><L><D><S><S><N><E><D><A><G><T><K><M><S><G><E><K><I>
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.<BOP>
O75688
Q15012
LAP4A_HUMAN
Golgi 4-transmembrane-spanning transporter MTP
Homo
<M><V><S><M><S><F><K><R><N><R><S><D><R><F><Y><S><T><R><C><C><G><C><C><H><V><R><T><G><T><I><I><L><G><T><W><Y><M><V><V><N><L><L><M><A><I><L><L><T><V><E><V><T><H><P><N><S><M><P><A><V><N><I><Q><Y><E><V><I><G><N><Y><Y><S><S><E><R><M><A><D><N><A><C><V><L><F><A><V><S><V><L><M><F><I><I><S><S><M><L><V><Y><G><A><I><S><Y><Q><V><G><W><L><I><P><F><F><C><Y><R><L><F><D><F><V><L><S><C><L><V><A><I><S><S><L><T><Y><L><P><R><I><K><E><Y><L><D><Q><L><P><D><F><P><Y><K><D><D><L><L><A><L><D><S><S><C><L><L><F><I><V><L><V><F><F><A><L><F><I><I><F><K><A><Y><L><I><N><C><V><W><N><C><Y><K><Y><I><N><N><R><N><V><P><E><I><A><V><Y><P><A><F><E><A><P><P><Q><Y><V><L><P><T><Y><E><M><A><V><K><M><P><E><K><E><P><P><P><P><Y><L><P><A>
May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.<BOP>
Q15012
B9EJG8
T150C_HUMAN
Transmembrane protein 150C
Homo
<M><D><G><K><K><C><S><V><W><M><F><L><P><L><V><F><T><L><F><T><S><A><G><L><W><I><V><Y><F><I><A><V><E><D><D><K><I><L><P><L><N><S><A><E><R><K><P><G><V><K><H><A><P><Y><I><S><I><A><G><D><D><P><P><A><S><C><V><F><S><Q><V><M><N><M><A><A><F><L><A><L><V><V><A><V><L><R><F><I><Q><L><K><P><K><V><L><N><P><W><L><N><I><S><G><L><V><A><L><C><L><A><S><F><G><M><T><L><L><G><N><F><Q><L><T><N><D><E><E><I><H><N><V><G><T><S><L><T><F><G><F><G><T><L><T><C><W><I><Q><A><A><L><T><L><K><V><N><I><K><N><E><G><R><R><V><G><I><P><R><V><I><L><S><A><S><I><T><L><C><V><V><L><Y><F><I><L><M><A><Q><S><I><H><M><Y><A><A><R><V><Q><W><G><L><V><M><C><F><L><S><Y><F><G><T><F><A><V><E><F><R><H><Y><R><Y><E><I><V><C><S><E><Y><Q><E><N><F><L><S><F><S><E><S><L><S><E><A><S><E><Y><Q><T><D><Q><V>
Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.<BOP>
B9EJG8
O14493
CLD4_HUMAN
Williams-Beuren syndrome chromosomal region 8 protein
Homo
<M><A><S><M><G><L><Q><V><M><G><I><A><L><A><V><L><G><W><L><A><V><M><L><C><C><A><L><P><M><W><R><V><T><A><F><I><G><S><N><I><V><T><S><Q><T><I><W><E><G><L><W><M><N><C><V><V><Q><S><T><G><Q><M><Q><C><K><V><Y><D><S><L><L><A><L><P><Q><D><L><Q><A><A><R><A><L><V><I><I><S><I><I><V><A><A><L><G><V><L><L><S><V><V><G><G><K><C><T><N><C><L><E><D><E><S><A><K><A><K><T><M><I><V><A><G><V><V><F><L><L><A><G><L><M><V><I><V><P><V><S><W><T><A><H><N><I><I><Q><D><F><Y><N><P><L><V><A><S><G><Q><K><R><E><M><G><A><S><L><Y><V><G><W><A><A><S><G><L><L><L><L><G><G><G><L><L><C><C><N><C><P><P><R><T><D><K><P><Y><S><A><K><Y><S><A><A><R><S><A><A><A><S><N><Y><V>
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
O14493
Q9Y243
AKT3_HUMAN
STK-2
Homo
<M><S><D><V><T><I><V><K><E><G><W><V><Q><K><R><G><E><Y><I><K><N><W><R><P><R><Y><F><L><L><K><T><D><G><S><F><I><G><Y><K><E><K><P><Q><D><V><D><L><P><Y><P><L><N><N><F><S><V><A><K><C><Q><L><M><K><T><E><R><P><K><P><N><T><F><I><I><R><C><L><Q><W><T><T><V><I><E><R><T><F><H><V><D><T><P><E><E><R><E><E><W><T><E><A><I><Q><A><V><A><D><R><L><Q><R><Q><E><E><E><R><M><N><C><S><P><T><S><Q><I><D><N><I><G><E><E><E><M><D><A><S><T><T><H><H><K><R><K><T><M><N><D><F><D><Y><L><K><L><L><G><K><G><T><F><G><K><V><I><L><V><R><E><K><A><S><G><K><Y><Y><A><M><K><I><L><K><K><E><V><I><I><A><K><D><E><V><A><H><T><L><T><E><S><R><V><L><K><N><T><R><H><P><F><L><T><S><L><K><Y><S><F><Q><T><K><D><R><L><C><F><V><M><E><Y><V><N><G><G><E><L><F><F><H><L><S><R><E><R><V><F><S><E><D><R><T><R><F><Y><G><A><E><I><V><S><A><L><D><Y><L><H><S><G><K><I><V><Y><R><D><L><K><L><E><N><L><M><L><D><K><D><G><H><I><K><I><T><D><F><G><L><C><K><E><G><I><T><D><A><A><T><M><K><T><F><C><G><T><P><E><Y><L><A><P><E><V><L><E><D><N><D><Y><G><R><A><V><D><W><W><G><L><G><V><V><M><Y><E><M><M><C><G><R><L><P><F><Y><N><Q><D><H><E><K><L><F><E><L><I><L><M><E><D><I><K><F><P><R><T><L><S><S><D><A><K><S><L><L><S><G><L><L><I><K><D><P><N><K><R><L><G><G><G><P><D><D><A><K><E><I><M><R><H><S><F><F><S><G><V><N><W><Q><D><V><Y><D><K><K><L><V><P><P><F><K><P><Q><V><T><S><E><T><D><T><R><Y><F><D><E><E><F><T><A><Q><T><I><T><I><T><P><P><E><K><Y><D><E><D><G><M><D><C><M><D><N><E><R><R><P><H><F><P><Q><F><S><Y><S><A><S><G><R><E>
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.<BOP>
Q9Y243
P13498
CY24A_HUMAN
p22-phox
Homo
<M><G><Q><I><E><W><A><M><W><A><N><E><Q><A><L><A><S><G><L><I><L><I><T><G><G><I><V><A><T><A><G><R><F><T><Q><W><Y><F><G><A><Y><S><I><V><A><G><V><F><V><C><L><L><E><Y><P><R><G><K><R><K><K><G><S><T><M><E><R><W><G><Q><K><Y><M><T><A><V><V><K><L><F><G><P><F><T><R><N><Y><Y><V><R><A><V><L><H><L><L><L><S><V><P><A><G><F><L><L><A><T><I><L><G><T><A><C><L><A><I><A><S><G><I><Y><L><L><A><A><V><R><G><E><Q><W><T><P><I><E><P><K><P><R><E><R><P><Q><I><G><G><T><I><K><Q><P><P><S><N><P><P><P><R><P><P><A><E><A><R><K><K><P><S><E><E><E><A><A><V><A><A><G><G><P><P><G><G><P><Q><V><N><P><I><P><V><T><D><E><V><V>
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.<BOP>
P13498
P35218
CAH5A_HUMAN
Carbonic anhydrase VA
Homo
<M><L><G><R><N><T><W><K><T><S><A><F><S><F><L><V><E><Q><M><W><A><P><L><W><S><R><S><M><R><P><G><R><W><C><S><Q><R><S><C><A><W><Q><T><S><N><N><T><L><H><P><L><W><T><V><P><V><S><V><P><G><G><T><R><Q><S><P><I><N><I><Q><W><R><D><S><V><Y><D><P><Q><L><K><P><L><R><V><S><Y><E><A><A><S><C><L><Y><I><W><N><T><G><Y><L><F><Q><V><E><F><D><D><A><T><E><A><S><G><I><S><G><G><P><L><E><N><H><Y><R><L><K><Q><F><H><F><H><W><G><A><V><N><E><G><G><S><E><H><T><V><D><G><H><A><Y><P><A><E><L><H><L><V><H><W><N><S><V><K><Y><Q><N><Y><K><E><A><V><V><G><E><N><G><L><A><V><I><G><V><F><L><K><L><G><A><H><H><Q><T><L><Q><R><L><V><D><I><L><P><E><I><K><H><K><D><A><R><A><A><M><R><P><F><D><P><S><T><L><L><P><T><C><W><D><Y><W><T><Y><A><G><S><L><T><T><P><P><L><T><E><S><V><T><W><I><I><Q><K><E><P><V><E><V><A><P><S><Q><L><S><A><F><R><T><L><L><F><S><A><L><G><E><E><E><K><M><M><V><N><N><Y><R><P><L><Q><P><L><M><N><R><K><V><W><A><S><F><Q><A><T><N><E><G><T><R><S>
Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 . Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles .<BOP>
P35218
Q05940
VMAT2_HUMAN
Vesicular amine transporter 2
Homo
<M><A><L><S><E><L><A><L><V><R><W><L><Q><E><S><R><R><S><R><K><L><I><L><F><I><V><F><L><A><L><L><L><D><N><M><L><L><T><V><V><V><P><I><I><P><S><Y><L><Y><S><I><K><H><E><K><N><A><T><E><I><Q><T><A><R><P><V><H><T><A><S><I><S><D><S><F><Q><S><I><F><S><Y><Y><D><N><S><T><M><V><T><G><N><A><T><R><D><L><T><L><H><Q><T><A><T><Q><H><M><V><T><N><A><S><A><V><P><S><D><C><P><S><E><D><K><D><L><L><N><E><N><V><Q><V><G><L><L><F><A><S><K><A><T><V><Q><L><I><T><N><P><F><I><G><L><L><T><N><R><I><G><Y><P><I><P><I><F><A><G><F><C><I><M><F><V><S><T><I><M><F><A><F><S><S><S><Y><A><F><L><L><I><A><R><S><L><Q><G><I><G><S><S><C><S><S><V><A><G><M><G><M><L><A><S><V><Y><T><D><D><E><E><R><G><N><V><M><G><I><A><L><G><G><L><A><M><G><V><L><V><G><P><P><F><G><S><V><L><Y><E><F><V><G><K><T><A><P><F><L><V><L><A><A><L><V><L><L><D><G><A><I><Q><L><F><V><L><Q><P><S><R><V><Q><P><E><S><Q><K><G><T><P><L><T><T><L><L><K><D><P><Y><I><L><I><A><A><G><S><I><C><F><A><N><M><G><I><A><M><L><E><P><A><L><P><I><W><M><M><E><T><M><C><S><R><K><W><Q><L><G><V><A><F><L><P><A><S><I><S><Y><L><I><G><T><N><I><F><G><I><L><A><H><K><M><G><R><W><L><C><A><L><L><G><M><I><I><V><G><V><S><I><L><C><I><P><F><A><K><N><I><Y><G><L><I><A><P><N><F><G><V><G><F><A><I><G><M><V><D><S><S><M><M><P><I><M><G><Y><L><V><D><L><R><H><V><S><V><Y><G><S><V><Y><A><I><A><D><V><A><F><C><M><G><Y><A><I><G><P><S><A><G><G><A><I><A><K><A><I><G><F><P><W><L><M><T><I><I><G><I><I><D><I><L><F><A><P><L><C><F><F><L><R><S><P><P><A><K><E><E><K><M><A><I><L><M><D><H><N><C><P><I><K><T><K><M><Y><T><Q><N><N><I><Q><S><Y><P><I><G><E><D><E><E><S><E><S><D>
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles . Requisite for vesicular amine storage prior to secretion via exocytosis.<BOP>
Q05940
Q8NBL3
T178A_HUMAN
Transmembrane protein 178A
Homo
<M><E><P><R><A><L><V><T><A><L><S><L><G><L><S><L><C><S><L><G><L><L><V><T><A><I><F><T><D><H><W><Y><E><T><D><P><R><R><H><K><E><S><C><E><R><S><R><A><G><A><D><P><P><D><Q><K><N><R><L><M><P><L><S><H><L><P><L><R><D><S><P><P><L><G><R><R><L><L><P><G><G><P><G><R><A><D><P><E><S><W><R><S><L><L><G><L><G><G><L><D><A><E><C><G><R><P><L><F><A><T><Y><S><G><L><W><R><K><C><Y><F><L><G><I><D><R><D><I><D><T><L><I><L><K><G><I><A><Q><R><C><T><A><I><K><Y><H><F><S><Q><P><I><R><L><R><N><I><P><F><N><L><T><K><T><I><Q><Q><D><E><W><H><L><L><H><L><R><R><I><T><A><G><F><L><G><M><A><V><A><V><L><L><C><G><C><I><V><A><T><V><S><F><F><W><E><E><S><L><T><Q><H><V><A><G><L><L><F><L><M><T><G><I><F><C><T><I><S><L><C><T><Y><A><A><S><I><S><Y><D><L><N><R><L><P><K><L><I><Y><S><L><P><A><D><V><E><H><G><Y><S><W><S><I><F><C><A><W><C><S><L><G><F><I><V><A><A><G><G><L><C><I><A><Y><P><F><I><S><R><T><K><I><A><Q><L><K><S><G><R><D><S><T><V>
Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.<BOP>
Q8NBL3
Q9NTU4
CTSRZ_HUMAN
Testis-expressed protein 40
Homo
<M><E><E><K><P><S><K><V><S><L><K><S><S><D><R><Q><G><S><D><E><E><S><V><H><S><D><T><R><D><L><W><T><T><T><T><L><S><Q><A><Q><L><N><M><P><L><S><E><V><C><E><G><F><D><E><E><G><R><N><I><S><K><T><R><G><W><H><S><P><G><R><G><S><L><D><E><G><Y><K><A><S><H><K><P><E><E><L><D><E><H><A><L><V><E><L><E><L><H><R><G><S><S><M><E><I><N><L><G><E><K><D><T><A><S><Q><I><E><A><E><K><S><S><S><M><S><S><L><N><I><A><K><H><M><P><H><R><A><Y><W><A><E><Q><Q><S><R><L><P><L><P><L><M><E><L><M><E><N><E><A><L><E><I><L><T><K><A><L><R><S><Y><Q><L><G><I><G><R><D><H><F><L><T><K><E><L><Q><R><Y><I><E><G><L><K><K><R><R><S><K><R><L><Y><V><N>
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.<BOP>
Q9NTU4
Q14019
COTL1_HUMAN
Coactosin-like protein
Homo
<M><A><T><K><I><D><K><E><A><C><R><A><A><Y><N><L><V><R><D><D><G><S><A><V><I><W><V><T><F><K><Y><D><G><S><T><I><V><P><G><E><Q><G><A><E><Y><Q><H><F><I><Q><Q><C><T><D><D><V><R><L><F><A><F><V><R><F><T><T><G><D><A><M><S><K><R><S><K><F><A><L><I><T><W><I><G><E><N><V><S><G><L><Q><R><A><K><T><G><T><D><K><T><L><V><K><E><V><V><Q><N><F><A><K><E><F><V><I><S><D><R><K><E><L><E><E><D><F><I><K><S><E><L><K><K><A><G><G><A><N><Y><D><A><Q><T><E>
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.<BOP>
Q14019
Q9H207
O10A5_HUMAN
Olfactory receptor-like protein JCG6
Homo
<M><A><I><G><N><W><T><E><I><S><E><F><I><L><M><S><F><S><S><L><P><T><E><I><Q><S><L><L><F><L><T><F><L><T><I><Y><L><V><T><L><K><G><N><S><L><I><I><L><V><T><L><A><D><P><M><L><H><S><P><M><Y><F><F><L><R><N><L><S><F><L><E><I><G><F><N><L><V><I><V><P><K><M><L><G><T><L><L><A><Q><D><T><T><I><S><F><L><G><C><A><T><Q><M><Y><F><F><F><F><F><G><V><A><E><C><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><S><P><L><H><Y><P><V><I><M><N><Q><R><T><R><A><K><L><A><A><A><S><W><F><P><G><F><P><V><A><T><V><Q><T><T><W><L><F><S><F><P><F><C><G><T><N><K><V><N><H><F><F><C><D><S><P><P><V><L><K><L><V><C><A><D><T><A><L><F><E><I><Y><A><I><V><G><T><I><L><V><V><M><I><P><C><L><L><I><L><C><S><Y><T><R><I><A><A><A><I><L><K><I><P><S><A><K><G><K><H><K><A><F><S><T><C><S><S><H><L><L><V><V><S><L><F><Y><I><S><S><S><L><T><Y><F><W><P><K><S><N><N><S><P><E><S><K><K><L><L><S><L><S><Y><T><V><V><T><P><M><L><N><P><I><I><Y><S><L><R><N><S><E><V><K><N><A><L><S><R><T><F><H><K><V><L><A><L><R><N><C><I><P>
Odorant receptor (Potential). May be involved in taste perception.<BOP>
Q9H207
P43307
SSRA_HUMAN
Signal sequence receptor subunit alpha
Homo
<M><R><L><L><P><R><L><L><L><L><L><L><L><V><F><P><A><T><V><L><F><R><G><G><P><R><G><L><L><A><V><A><Q><D><L><T><E><D><E><E><T><V><E><D><S><I><I><E><D><E><D><D><E><A><E><V><E><E><D><E><P><T><D><L><V><E><D><K><E><E><E><D><V><S><G><E><P><E><A><S><P><S><A><D><T><T><I><L><F><V><K><G><E><D><F><P><A><N><N><I><V><K><F><L><V><G><F><T><N><K><G><T><E><D><F><I><V><E><S><L><D><A><S><F><R><Y><P><Q><D><Y><Q><F><Y><I><Q><N><F><T><A><L><P><L><N><T><V><V><P><P><Q><R><Q><A><T><F><E><Y><S><F><I><P><A><E><P><M><G><G><R><P><F><G><L><V><I><N><L><N><Y><K><D><L><N><G><N><V><F><Q><D><A><V><F><N><Q><T><V><T><V><I><E><R><E><D><G><L><D><G><E><T><I><F><M><Y><M><F><L><A><G><L><G><L><L><V><I><V><G><L><H><Q><L><L><E><S><R><K><R><K><R><P><I><Q><K><V><E><M><G><T><S><S><Q><N><D><V><D><M><S><W><I><P><Q><E><T><L><N><Q><I><N><K><A><S><P><R><R><L><P><R><K><R><A><Q><K><R><S><V><G><S><D><E>
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.<BOP>
P43307
P02774
VTDB_HUMAN
Vitamin D-binding protein-macrophage activating factor
Homo
<M><K><R><V><L><V><L><L><L><A><V><A><F><G><H><A><L><E><R><G><R><D><Y><E><K><N><K><V><C><K><E><F><S><H><L><G><K><E><D><F><T><S><L><S><L><V><L><Y><S><R><K><F><P><S><G><T><F><E><Q><V><S><Q><L><V><K><E><V><V><S><L><T><E><A><C><C><A><E><G><A><D><P><D><C><Y><D><T><R><T><S><A><L><S><A><K><S><C><E><S><N><S><P><F><P><V><H><P><G><T><A><E><C><C><T><K><E><G><L><E><R><K><L><C><M><A><A><L><K><H><Q><P><Q><E><F><P><T><Y><V><E><P><T><N><D><E><I><C><E><A><F><R><K><D><P><K><E><Y><A><N><Q><F><M><W><E><Y><S><T><N><Y><G><Q><A><P><L><S><L><L><V><S><Y><T><K><S><Y><L><S><M><V><G><S><C><C><T><S><A><S><P><T><V><C><F><L><K><E><R><L><Q><L><K><H><L><S><L><L><T><T><L><S><N><R><V><C><S><Q><Y><A><A><Y><G><E><K><K><S><R><L><S><N><L><I><K><L><A><Q><K><V><P><T><A><D><L><E><D><V><L><P><L><A><E><D><I><T><N><I><L><S><K><C><C><E><S><A><S><E><D><C><M><A><K><E><L><P><E><H><T><V><K><L><C><D><N><L><S><T><K><N><S><K><F><E><D><C><C><Q><E><K><T><A><M><D><V><F><V><C><T><Y><F><M><P><A><A><Q><L><P><E><L><P><D><V><E><L><P><T><N><K><D><V><C><D><P><G><N><T><K><V><M><D><K><Y><T><F><E><L><S><R><R><T><H><L><P><E><V><F><L><S><K><V><L><E><P><T><L><K><S><L><G><E><C><C><D><V><E><D><S><T><T><C><F><N><A><K><G><P><L><L><K><K><E><L><S><S><F><I><D><K><G><Q><E><L><C><A><D><Y><S><E><N><T><F><T><E><Y><K><K><K><L><A><E><R><L><K><A><K><L><P><D><A><T><P><T><E><L><A><K><L><V><N><K><H><S><D><F><A><S><N><C><C><S><I><N><S><P><P><L><Y><C><D><S><E><I><D><A><E><L><K><N><I><L>
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.<BOP>
P02774
Q32P41
TRM5_HUMAN
tRNA methyltransferase 5 homolog
Homo
<M><V><L><W><I><L><W><R><P><F><G><F><S><G><R><F><L><K><L><E><S><H><S><I><T><E><S><K><S><L><I><P><V><A><W><T><S><L><T><Q><M><L><L><E><A><P><G><I><F><L><L><G><Q><R><K><R><F><S><T><M><P><E><T><E><T><H><E><R><E><T><E><L><F><S><P><P><S><D><V><R><G><M><T><K><L><D><R><T><A><F><K><K><T><V><N><I><P><V><L><K><V><R><K><E><I><V><S><K><L><M><R><S><L><K><R><A><A><L><Q><R><P><G><I><R><R><V><I><E><D><P><E><D><K><E><S><R><L><I><M><L><D><P><Y><K><I><F><T><H><D><S><F><E><K><A><E><L><S><V><L><E><Q><L><N><V><S><P><Q><I><S><K><Y><N><L><E><L><T><Y><E><H><F><K><S><E><E><I><L><R><A><V><L><P><E><G><Q><D><V><T><S><G><F><S><R><I><G><H><I><A><H><L><N><L><R><D><H><Q><L><S><F><K><H><L><I><G><Q><V><M><I><D><K><N><P><G><I><T><S><A><V><N><K><I><N><N><I><D><N><M><Y><R><N><F><Q><M><E><V><L><S><G><E><Q><N><M><M><T><K><V><R><E><N><N><Y><T><Y><E><F><D><F><S><K><V><Y><W><N><P><R><L><S><T><E><H><S><R><I><T><E><L><L><K><P><G><D><V><L><F><D><V><F><A><G><V><G><P><F><A><I><P><V><A><K><K><N><C><T><V><F><A><N><D><L><N><P><E><S><H><K><W><L><L><Y><N><C><K><L><N><K><V><D><Q><K><V><K><V><F><N><L><D><G><K><D><F><L><Q><G><P><V><K><E><E><L><M><Q><L><L><G><L><S><K><E><R><K><P><S><V><H><V><V><M><N><L><P><A><K><A><I><E><F><L><S><A><F><K><W><L><L><D><G><Q><P><C><S><S><E><F><L><P><I><V><H><C><Y><S><F><S><K><D><A><N><P><A><E><D><V><R><Q><R><A><G><A><V><L><G><I><S><L><E><A><C><S><S><V><H><L><V><R><N><V><A><P><N><K><E><M><L><C><I><T><F><Q><I><P><A><S><V><L><Y><K><N><Q><T><R><N><P><E><N><H><E><D><P><P><L><K><R><Q><R><T><A><E><A><F><S><D><E><K><T><Q><I><V><S><N><T>
Involved in mitochondrial tRNA methylation . Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.<BOP>
Q32P41