accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
P22692
IBP4_HUMAN
Insulin-like growth factor-binding protein 4
Homo
<M><L><P><L><C><L><V><A><A><L><L><L><A><A><G><P><G><P><S><L><G><D><E><A><I><H><C><P><P><C><S><E><E><K><L><A><R><C><R><P><P><V><G><C><E><E><L><V><R><E><P><G><C><G><C><C><A><T><C><A><L><G><L><G><M><P><C><G><V><Y><T><P><R><C><G><S><G><L><R><C><Y><P><P><R><G><V><E><K><P><L><H><T><L><M><H><G><Q><G><V><C><M><E><L><A><E><I><E><A><I><Q><E><S><L><Q><P><S><D><K><D><E><G><D><H><P><N><N><S><F><S><P><C><S><A><H><D><R><R><C><L><Q><K><H><F><A><K><I><R><D><R><S><T><S><G><G><K><M><K><V><N><G><A><P><R><E><D><A><R><P><V><P><Q><G><S><C><Q><S><E><L><H><R><A><L><E><R><L><A><A><S><Q><S><R><T><H><E><D><L><Y><I><I><P><I><P><N><C><D><R><N><G><N><F><H><P><K><Q><C><H><P><A><L><D><G><Q><R><G><K><C><W><C><V><D><R><K><T><G><V><K><L><P><G><G><L><E><P><K><G><E><L><D><C><H><Q><L><A><D><S><F><R><E>
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.<BOP>
P22692
P10997
IAPP_HUMAN
Insulinoma amyloid peptide
Homo
<M><G><I><L><K><L><Q><V><F><L><I><V><L><S><V><A><L><N><H><L><K><A><T><P><I><E><S><H><Q><V><E><K><R><K><C><N><T><A><T><C><A><T><Q><R><L><A><N><F><L><V><H><S><S><N><N><F><G><A><I><L><S><S><T><N><V><G><S><N><T><Y><G><K><R><N><A><V><E><V><L><K><R><E><P><L><N><Y><L><P><L>
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.<BOP>
P10997
Q9NXT0
ZN586_HUMAN
Zinc finger protein 586
Homo
<M><A><A><A><A><A><L><R><A><P><A><Q><S><S><V><T><F><E><D><V><A><V><N><F><S><L><E><E><W><S><L><L><N><E><A><Q><R><C><L><Y><R><D><V><M><L><E><T><L><T><L><I><S><S><L><G><C><W><H><G><G><E><D><E><A><A><P><S><K><Q><S><T><C><I><H><I><Y><K><D><Q><G><G><H><S><G><E><R><P><Y><E><C><G><E><Y><R><K><L><F><K><N><K><S><C><L><T><E><P><R><R><D><H><K><H><R><N><V><R><T><G><E><R><P><Y><E><C><S><K><Y><G><K><L><F><H><Q><K><P><T><L><H><I><H><E><R><F><H><T><G><Q><K><T><Y><E><C><S><E><C><G><K><S><F><H><Q><S><S><S><L><L><Q><R><Q><T><L><H><T><R><E><R><P><Y><E><C><I><E><C><G><K><A><F><A><E><K><S><S><L><I><N><H><R><K><V><H><S><G><A><K><R><Y><E><C><N><E><C><G><K><S><F><A><Y><T><S><S><L><I><K><H><R><R><I><H><T><G><E><R><P><Y><E><C><S><E><C><G><R><S><F><A><E><N><S><S><L><I><K><H><L><R><V><H><T><G><E><R><P><Y><E><C><V><E><C><G><K><S><F><R><R><S><S><S><L><L><Q><H><Q><R><V><H><T><R><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><L><R><S><N><L><I><H><H><Q><R><V><H><T><G><E><R><H><E><C><G><Q><C><G><K><S><F><S><R><K><S><S><L><I><I><H><L><R><V><H><T><G><E><R><P><Y><E><C><S><D><C><G><K><S><F><A><E><N><S><S><L><I><K><H><L><R><V><H><T><G><E><R><P><Y><E><C><I><D><C><G><K><S><F><R><H><S><S><S><F><R><R><H><Q><R><V><H><T><G><M><R><P><Y><K>
May be involved in transcriptional regulation.<BOP>
Q9NXT0
Q9Y572
RIPK3_HUMAN
Receptor-interacting protein 3
Homo
<M><S><C><V><K><L><W><P><S><G><A><P><A><P><L><V><S><I><E><E><L><E><N><Q><E><L><V><G><K><G><G><F><G><T><V><F><R><A><Q><H><R><K><W><G><Y><D><V><A><V><K><I><V><N><S><K><A><I><S><R><E><V><K><A><M><A><S><L><D><N><E><F><V><L><R><L><E><G><V><I><E><K><V><N><W><D><Q><D><P><K><P><A><L><V><T><K><F><M><E><N><G><S><L><S><G><L><L><Q><S><Q><C><P><R><P><W><P><L><L><C><R><L><L><K><E><V><V><L><G><M><F><Y><L><H><D><Q><N><P><V><L><L><H><R><D><L><K><P><S><N><V><L><L><D><P><E><L><H><V><K><L><A><D><F><G><L><S><T><F><Q><G><G><S><Q><S><G><T><G><S><G><E><P><G><G><T><L><G><Y><L><A><P><E><L><F><V><N><V><N><R><K><A><S><T><A><S><D><V><Y><S><F><G><I><L><M><W><A><V><L><A><G><R><E><V><E><L><P><T><E><P><S><L><V><Y><E><A><V><C><N><R><Q><N><R><P><S><L><A><E><L><P><Q><A><G><P><E><T><P><G><L><E><G><L><K><E><L><M><Q><L><C><W><S><S><E><P><K><D><R><P><S><F><Q><E><C><L><P><K><T><D><E><V><F><Q><M><V><E><N><N><M><N><A><A><V><S><T><V><K><D><F><L><S><Q><L><R><S><S><N><R><R><F><S><I><P><E><S><G><Q><G><G><T><E><M><D><G><F><R><R><T><I><E><N><Q><H><S><R><N><D><V><M><V><S><E><W><L><N><K><L><N><L><E><E><P><P><S><S><V><P><K><K><C><P><S><L><T><K><R><S><R><A><Q><E><E><Q><V><P><Q><A><W><T><A><G><T><S><S><D><S><M><A><Q><P><P><Q><T><P><E><T><S><T><F><R><N><Q><M><P><S><P><T><S><T><G><T><P><S><P><G><P><R><G><N><Q><G><A><E><R><Q><G><M><N><W><S><C><R><T><P><E><P><N><P><V><T><G><R><P><L><V><N><I><Y><N><C><S><G><V><Q><V><G><D><N><N><Y><L><T><M><Q><Q><T><T><A><L><P><T><W><G><L><A><P><S><G><K><G><R><G><L><Q><H><P><P><P><V><G><S><Q><E><G><P><K><D><P><E><A><W><S><R><P><Q><G><W><Y><N><H><S><G><K>
(Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms heteromeric amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit RIPK3-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion.<BOP>
Q9Y572
Q12829
RB40B_HUMAN
SOCS box-containing protein RAR
Homo
<M><S><A><L><G><S><P><V><R><A><Y><D><F><L><L><K><F><L><L><V><G><D><S><D><V><G><K><G><E><I><L><A><S><L><Q><D><G><A><A><E><S><P><Y><G><H><P><A><G><I><D><Y><K><T><T><T><I><L><L><D><G><R><R><V><K><L><Q><L><W><D><T><S><G><Q><G><R><F><C><T><I><F><R><S><Y><S><R><G><A><Q><G><V><I><L><V><Y><D><I><A><N><R><W><S><F><D><G><I><D><R><W><I><K><E><I><D><E><H><A><P><G><V><P><K><I><L><V><G><N><R><L><H><L><A><F><K><R><Q><V><P><T><E><Q><A><Q><A><Y><A><E><R><L><G><V><T><F><F><E><V><S><P><L><C><N><F><N><I><T><E><S><F><T><E><L><A><R><I><V><L><L><R><H><G><M><D><R><L><W><R><P><S><K><V><L><S><L><Q><D><L><C><C><R><A><V><V><S><C><T><P><V><H><L><V><D><K><L><P><L><P><I><A><L><R><S><H><L><K><S><F><S><M><A><N><G><L><N><A><R><M><M><H><G><G><S><Y><S><L><T><T><S><S><T><H><K><R><S><S><L><R><K><V><K><L><V><R><P><P><Q><S><P><P><K><N><C><T><R><N><S><C><K><I><S>
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP>
Q12829
Q9UMQ6
CAN11_HUMAN
Calcium-activated neutral proteinase 11
Homo
<M><L><Y><S><P><G><P><S><L><P><E><S><A><E><S><L><D><G><S><Q><E><D><K><P><R><G><S><C><A><E><P><T><F><T><D><T><G><M><V><A><H><I><N><N><S><R><L><K><A><K><G><V><G><Q><H><D><N><A><Q><N><F><G><N><Q><S><F><E><E><L><R><A><A><C><L><R><K><G><E><L><F><E><D><P><L><F><P><A><E><P><S><S><L><G><F><K><D><L><G><P><N><S><K><N><V><Q><N><I><S><W><Q><R><P><K><D><I><I><N><N><P><L><F><I><M><D><G><I><S><P><T><D><I><C><Q><G><I><L><G><D><C><W><L><L><A><A><I><G><S><L><T><T><C><P><K><L><L><Y><R><V><V><P><R><G><Q><S><F><K><K><N><Y><A><G><I><F><H><F><Q><I><W><Q><F><G><Q><W><V><N><V><V><V><D><D><R><L><P><T><K><N><D><K><L><V><F><V><H><S><T><E><R><S><E><F><W><S><A><L><L><E><K><A><Y><A><K><L><S><G><S><Y><E><A><L><S><G><G><S><T><M><E><G><L><E><D><F><T><G><G><V><A><Q><S><F><Q><L><Q><R><P><P><Q><N><L><L><R><L><L><R><K><A><V><E><R><S><S><L><M><G><C><S><I><E><V><T><S><D><S><E><L><E><S><M><T><D><K><M><L><V><R><G><H><A><Y><S><V><T><G><L><Q><D><V><H><Y><R><G><K><M><E><T><L><I><R><V><R><N><P><W><G><R><I><E><W><N><G><A><W><S><D><S><A><R><E><W><E><E><V><A><S><D><I><Q><M><Q><L><L><H><K><T><E><D><G><E><F><W><M><S><Y><Q><D><F><L><N><N><F><T><L><L><E><I><C><N><L><T><P><D><T><L><S><G><D><Y><K><S><Y><W><H><T><T><F><Y><E><G><S><W><R><R><G><S><S><A><G><G><C><R><N><H><P><G><T><F><W><T><N><P><Q><F><K><I><S><L><P><E><G><D><D><P><E><D><D><A><E><G><N><V><V><V><C><T><C><L><V><A><L><M><Q><K><N><W><R><H><A><R><Q><Q><G><A><Q><L><Q><T><I><G><F><V><L><Y><A><V><P><K><E><F><Q><N><I><Q><D><V><H><L><K><K><E><F><F><T><K><Y><Q><D><H><G><F><S><E><I><F><T><N><S><R><E><V><S><S><Q><L><R><L><P><P><G><E><Y><I><I><I><P><S><T><F><E><P><H><R><D><A><D><F><L><L><R><V><F><T><E><K><H><S><E><S><W><E><L><D><E><V><N><Y><A><E><Q><L><Q><E><E><K><V><S><E><D><D><M><D><Q><D><F><L><H><L><F><K><I><V><A><G><E><G><K><E><I><G><V><Y><E><L><Q><R><L><L><N><R><M><A><I><K><F><K><S><F><K><T><K><G><F><G><L><D><A><C><R><C><M><I><N><L><M><D><K><D><G><S><G><K><L><G><L><L><E><F><K><I><L><W><K><K><L><K><K><W><M><D><I><F><R><E><C><D><Q><D><H><S><G><T><L><N><S><Y><E><M><R><L><V><I><E><K><A><G><I><K><L><N><N><K><V><M><Q><V><L><V><A><R><Y><A><D><D><D><L><I><I><D><F><D><S><F><I><S><C><F><L><R><L><K><T><M><F><T><F><F><L><T><M><D><P><K><N><T><G><H><I><C><L><S><L><E><Q><W><L><Q><M><T><M><W><G>
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.<BOP>
Q9UMQ6
Q99217
AMELX_HUMAN
Amelogenin, X isoform
Homo
<M><G><T><W><I><L><F><A><C><L><L><G><A><A><F><A><M><P><L><P><P><H><P><G><H><P><G><Y><I><N><F><S><Y><E><V><L><T><P><L><K><W><Y><Q><S><I><R><P><P><Y><P><S><Y><G><Y><E><P><M><G><G><W><L><H><H><Q><I><I><P><V><L><S><Q><Q><H><P><P><T><H><T><L><Q><P><H><H><H><I><P><V><V><P><A><Q><Q><P><V><I><P><Q><Q><P><M><M><P><V><P><G><Q><H><S><M><T><P><I><Q><H><H><Q><P><N><L><P><P><P><A><Q><Q><P><Y><Q><P><Q><P><V><Q><P><Q><P><H><Q><P><M><Q><P><Q><P><P><V><H><P><M><Q><P><L><P><P><Q><P><P><L><P><P><M><F><P><M><Q><P><L><P><P><M><L><P><D><L><T><L><E><A><W><P><S><T><D><K><T><K><R><E><E><V><D>
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.<BOP>
Q99217
P11182
ODB2_HUMAN
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Homo
<M><A><A><V><R><M><L><R><T><W><S><R><N><A><G><K><L><I><C><V><R><Y><F><Q><T><C><G><N><V><H><V><L><K><P><N><Y><V><C><F><F><G><Y><P><S><F><K><Y><S><H><P><H><H><F><L><K><T><T><A><A><L><R><G><Q><V><V><Q><F><K><L><S><D><I><G><E><G><I><R><E><V><T><V><K><E><W><Y><V><K><E><G><D><T><V><S><Q><F><D><S><I><C><E><V><Q><S><D><K><A><S><V><T><I><T><S><R><Y><D><G><V><I><K><K><L><Y><Y><N><L><D><D><I><A><Y><V><G><K><P><L><V><D><I><E><T><E><A><L><K><D><S><E><E><D><V><V><E><T><P><A><V><S><H><D><E><H><T><H><Q><E><I><K><G><R><K><T><L><A><T><P><A><V><R><R><L><A><M><E><N><N><I><K><L><S><E><V><V><G><S><G><K><D><G><R><I><L><K><E><D><I><L><N><Y><L><E><K><Q><T><G><A><I><L><P><P><S><P><K><V><E><I><M><P><P><P><P><K><P><K><D><M><T><V><P><I><L><V><S><K><P><P><V><F><T><G><K><D><K><T><E><P><I><K><G><F><Q><K><A><M><V><K><T><M><S><A><A><L><K><I><P><H><F><G><Y><C><D><E><I><D><L><T><E><L><V><K><L><R><E><E><L><K><P><I><A><F><A><R><G><I><K><L><S><F><M><P><F><F><L><K><A><A><S><L><G><L><L><Q><F><P><I><L><N><A><S><V><D><E><N><C><Q><N><I><T><Y><K><A><S><H><N><I><G><I><A><M><D><T><E><Q><G><L><I><V><P><N><V><K><N><V><Q><I><C><S><I><F><D><I><A><T><E><L><N><R><L><Q><K><L><G><S><V><G><Q><L><S><T><T><D><L><T><G><G><T><F><T><L><S><N><I><G><S><I><G><G><T><F><A><K><P><V><I><M><P><P><E><V><A><I><G><A><L><G><S><I><K><A><I><P><R><F><N><Q><K><G><E><V><Y><K><A><Q><I><M><N><V><S><W><S><A><D><H><R><V><I><D><G><A><T><M><S><R><F><S><N><L><W><K><S><Y><L><E><N><P><A><F><M><L><L><D><L><K>
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.<BOP>
P11182
O43252
PAPS1_HUMAN
Adenylylsulfate 3'-phosphotransferase
Homo
<M><E><I><P><G><S><L><C><K><K><V><K><L><S><N><N><A><Q><N><W><G><M><Q><R><A><T><N><V><T><Y><Q><A><H><H><V><S><R><N><K><R><G><Q><V><V><G><T><R><G><G><F><R><G><C><T><V><W><L><T><G><L><S><G><A><G><K><T><T><V><S><M><A><L><E><E><Y><L><V><C><H><G><I><P><C><Y><T><L><D><G><D><N><I><R><Q><G><L><N><K><N><L><G><F><S><P><E><D><R><E><E><N><V><R><R><I><A><E><V><A><K><L><F><A><D><A><G><L><V><C><I><T><S><F><I><S><P><Y><T><Q><D><R><N><N><A><R><Q><I><H><E><G><A><S><L><P><F><F><E><V><F><V><D><A><P><L><H><V><C><E><Q><R><D><V><K><G><L><Y><K><K><A><R><A><G><E><I><K><G><F><T><G><I><D><S><E><Y><E><K><P><E><A><P><E><L><V><L><K><T><D><S><C><D><V><N><D><C><V><Q><Q><V><V><E><L><L><Q><E><R><D><I><V><P><V><D><A><S><Y><E><V><K><E><L><Y><V><P><E><N><K><L><H><L><A><K><T><D><A><E><T><L><P><A><L><K><I><N><K><V><D><M><Q><W><V><Q><V><L><A><E><G><W><A><T><P><L><N><G><F><M><R><E><R><E><Y><L><Q><C><L><H><F><D><C><L><L><D><G><G><V><I><N><L><S><V><P><I><V><L><T><A><T><H><E><D><K><E><R><L><D><G><C><T><A><F><A><L><M><Y><E><G><R><R><V><A><I><L><R><N><P><E><F><F><E><H><R><K><E><E><R><C><A><R><Q><W><G><T><T><C><K><N><H><P><Y><I><K><M><V><M><E><Q><G><D><W><L><I><G><G><D><L><Q><V><L><D><R><V><Y><W><N><D><G><L><D><Q><Y><R><L><T><P><T><E><L><K><Q><K><F><K><D><M><N><A><D><A><V><F><A><F><Q><L><R><N><P><V><H><N><G><H><A><L><L><M><Q><D><T><H><K><Q><L><L><E><R><G><Y><R><R><P><V><L><L><L><H><P><L><G><G><W><T><K><D><D><D><V><P><L><M><W><R><M><K><Q><H><A><A><V><L><E><E><G><V><L><N><P><E><T><T><V><V><A><I><F><P><S><P><M><M><Y><A><G><P><T><E><V><Q><W><H><C><R><A><R><M><V><A><G><A><N><F><Y><I><V><G><R><D><P><A><G><M><P><H><P><E><T><G><K><D><L><Y><E><P><S><H><G><A><K><V><L><T><M><A><P><G><L><I><T><L><E><I><V><P><F><R><V><A><A><Y><N><K><K><K><K><R><M><D><Y><Y><D><S><E><H><H><E><D><F><E><F><I><S><G><T><R><M><R><K><L><A><R><E><G><Q><K><P><P><E><G><F><M><A><P><K><A><W><T><V><L><T><E><Y><Y><K><S><L><E><K><A>
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway . Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells .<BOP>
O43252
Q9NP98
MYOZ1_HUMAN
Protein FATZ
Homo
<M><P><L><S><G><T><P><A><P><N><K><K><R><K><S><S><K><L><I><M><E><L><T><G><G><G><Q><E><S><S><G><L><N><L><G><K><K><I><S><V><P><R><D><V><M><L><E><E><L><S><L><L><T><N><R><G><S><K><M><F><K><L><R><Q><M><R><V><E><K><F><I><Y><E><N><H><P><D><V><F><S><D><S><S><M><D><H><F><Q><K><F><L><P><T><V><G><G><Q><L><G><T><A><G><Q><G><F><S><Y><S><K><S><N><G><R><G><G><S><Q><A><G><G><S><G><S><A><G><Q><Y><G><S><D><Q><Q><H><H><L><G><S><G><S><G><A><G><G><T><G><G><P><A><G><Q><A><G><R><G><G><A><A><G><T><A><G><V><G><E><T><G><S><G><D><Q><A><G><G><E><G><K><H><I><T><V><F><K><T><Y><I><S><P><W><E><R><A><M><G><V><D><P><Q><Q><K><M><E><L><G><I><D><L><L><A><Y><G><A><K><A><E><L><P><K><Y><K><S><F><N><R><T><A><M><P><Y><G><G><Y><E><K><A><S><K><R><M><T><F><Q><M><P><K><F><D><L><G><P><L><L><S><E><P><L><V><L><Y><N><Q><N><L><S><N><R><P><S><F><N><R><T><P><I><P><W><L><S><S><G><E><P><V><D><Y><N><V><D><I><G><I><P><L><D><G><E><T><E><E><L>
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.<BOP>
Q9NP98
Q8NGS2
OR1J2_HUMAN
Olfactory receptor OR9-19
Homo
<M><S><P><E><N><Q><S><S><V><S><E><F><L><L><L><G><L><P><I><R><P><E><Q><Q><A><V><F><F><T><L><F><L><G><M><Y><L><T><T><V><L><G><N><L><L><I><M><L><L><I><Q><L><D><S><H><L><H><T><P><M><Y><F><F><L><S><H><L><A><L><T><D><I><S><F><S><S><V><T><V><P><K><M><L><M><D><M><R><T><K><Y><K><S><I><L><Y><E><E><C><I><S><Q><M><Y><F><F><I><F><F><T><D><L><D><S><F><L><I><T><S><M><A><Y><D><R><Y><V><A><I><C><H><P><L><H><Y><T><V><I><M><R><E><E><L><C><V><F><L><V><A><V><S><W><I><L><S><C><A><S><S><L><S><H><T><L><L><L><T><R><L><S><F><C><A><A><N><T><I><P><H><V><F><C><D><L><A><A><L><L><K><L><S><C><S><D><I><F><L><N><E><L><V><M><F><T><V><G><V><V><V><I><T><L><P><F><M><C><I><L><V><S><Y><G><Y><I><G><A><T><I><L><R><V><P><S><T><K><G><I><H><K><A><L><S><T><C><G><S><H><L><S><V><V><S><L><Y><Y><G><S><I><F><G><Q><Y><L><F><P><T><V><S><S><S><I><D><K><D><V><I><V><A><L><M><Y><T><V><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><R><D><M><K><E><A><L><G><K><L><F><S><R><A><T><F><F><S><W>
Odorant receptor.<BOP>
Q8NGS2
Q96AY3
FKB10_HUMAN
Rotamase
Homo
<M><F><P><A><G><P><P><S><H><S><L><L><R><L><P><L><L><Q><L><L><L><L><V><V><Q><A><V><G><R><G><L><G><R><A><S><P><A><G><G><P><L><E><D><V><V><I><E><R><Y><H><I><P><R><A><C><P><R><E><V><Q><M><G><D><F><V><R><Y><H><Y><N><G><T><F><E><D><G><K><K><F><D><S><S><Y><D><R><N><T><L><V><A><I><V><V><G><V><G><R><L><I><T><G><M><D><R><G><L><M><G><M><C><V><N><E><R><R><R><L><I><V><P><P><H><L><G><Y><G><S><I><G><L><A><G><L><I><P><P><D><A><T><L><Y><F><D><V><V><L><L><D><V><W><N><K><E><D><T><V><Q><V><S><T><L><L><R><P><P><H><C><P><R><M><V><Q><D><G><D><F><V><R><Y><H><Y><N><G><T><L><L><D><G><T><S><F><D><T><S><Y><S><K><G><G><T><Y><D><T><Y><V><G><S><G><W><L><I><K><G><M><D><Q><G><L><L><G><M><C><P><G><E><R><R><K><I><I><I><P><P><F><L><A><Y><G><E><K><G><Y><G><T><V><I><P><P><Q><A><S><L><V><F><H><V><L><L><I><D><V><H><N><P><K><D><A><V><Q><L><E><T><L><E><L><P><P><G><C><V><R><R><A><G><A><G><D><F><M><R><Y><H><Y><N><G><S><L><M><D><G><T><L><F><D><S><S><Y><S><R><N><H><T><Y><N><T><Y><I><G><Q><G><Y><I><I><P><G><M><D><Q><G><L><Q><G><A><C><M><G><E><R><R><R><I><T><I><P><P><H><L><A><Y><G><E><N><G><T><G><D><K><I><P><G><S><A><V><L><I><F><N><V><H><V><I><D><F><H><N><P><A><D><V><V><E><I><R><T><L><S><R><P><S><E><T><C><N><E><T><T><K><L><G><D><F><V><R><Y><H><Y><N><C><S><L><L><D><G><T><Q><L><F><T><S><H><D><Y><G><A><P><Q><E><A><T><L><G><A><N><K><V><I><E><G><L><D><T><G><L><Q><G><M><C><V><G><E><R><R><Q><L><I><V><P><P><H><L><A><H><G><E><S><G><A><R><G><V><P><G><S><A><V><L><L><F><E><V><E><L><V><S><R><E><D><G><L><P><T><G><Y><L><F><V><W><H><K><D><P><P><A><N><L><F><E><D><M><D><L><N><K><D><G><E><V><P><P><E><E><F><S><T><F><I><K><A><Q><V><S><E><G><K><G><R><L><M><P><G><Q><D><P><E><K><T><I><G><D><M><F><Q><N><Q><D><R><N><Q><D><G><K><I><T><V><D><E><L><K><L><K><S><D><E><D><E><E><R><V><H><E><E><L>
PPIases accelerate the folding of proteins during protein synthesis.<BOP>
Q96AY3
P34913
HYES_HUMAN
Lipid-phosphate phosphatase
Homo
<M><T><L><R><A><A><V><F><D><L><D><G><V><L><A><L><P><A><V><F><G><V><L><G><R><T><E><E><A><L><A><L><P><R><G><L><L><N><D><A><F><Q><K><G><G><P><E><G><A><T><T><R><L><M><K><G><E><I><T><L><S><Q><W><I><P><L><M><E><E><N><C><R><K><C><S><E><T><A><K><V><C><L><P><K><N><F><S><I><K><E><I><F><D><K><A><I><S><A><R><K><I><N><R><P><M><L><Q><A><A><L><M><L><R><K><K><G><F><T><T><A><I><L><T><N><T><W><L><D><D><R><A><E><R><D><G><L><A><Q><L><M><C><E><L><K><M><H><F><D><F><L><I><E><S><C><Q><V><G><M><V><K><P><E><P><Q><I><Y><K><F><L><L><D><T><L><K><A><S><P><S><E><V><V><F><L><D><D><I><G><A><N><L><K><P><A><R><D><L><G><M><V><T><I><L><V><Q><D><T><D><T><A><L><K><E><L><E><K><V><T><G><I><Q><L><L><N><T><P><A><P><L><P><T><S><C><N><P><S><D><M><S><H><G><Y><V><T><V><K><P><R><V><R><L><H><F><V><E><L><G><S><G><P><A><V><C><L><C><H><G><F><P><E><S><W><Y><S><W><R><Y><Q><I><P><A><L><A><Q><A><G><Y><R><V><L><A><M><D><M><K><G><Y><G><E><S><S><A><P><P><E><I><E><E><Y><C><M><E><V><L><C><K><E><M><V><T><F><L><D><K><L><G><L><S><Q><A><V><F><I><G><H><D><W><G><G><M><L><V><W><Y><M><A><L><F><Y><P><E><R><V><R><A><V><A><S><L><N><T><P><F><I><P><A><N><P><N><M><S><P><L><E><S><I><K><A><N><P><V><F><D><Y><Q><L><Y><F><Q><E><P><G><V><A><E><A><E><L><E><Q><N><L><S><R><T><F><K><S><L><F><R><A><S><D><E><S><V><L><S><M><H><K><V><C><E><A><G><G><L><F><V><N><S><P><E><E><P><S><L><S><R><M><V><T><E><E><E><I><Q><F><Y><V><Q><Q><F><K><K><S><G><F><R><G><P><L><N><W><Y><R><N><M><E><R><N><W><K><W><A><C><K><S><L><G><R><K><I><L><I><P><A><L><M><V><T><A><E><K><D><F><V><L><V><P><Q><M><S><Q><H><M><E><D><W><I><P><H><L><K><R><G><H><I><E><D><C><G><H><W><T><Q><M><D><K><P><T><E><V><N><Q><I><L><I><K><W><L><D><S><D><A><R><N><P><P><V><V><S><K><M>
Bifunctional enzyme . The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid . Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates .<BOP>
P34913
Q9P0G3
KLK14_HUMAN
Kallikrein-like protein 6
Homo
<M><S><L><R><V><L><G><S><G><T><W><P><S><A><P><K><M><F><L><L><L><T><A><L><Q><V><L><A><I><A><M><T><Q><S><Q><E><D><E><N><K><I><I><G><G><H><T><C><T><R><S><S><Q><P><W><Q><A><A><L><L><A><G><P><R><R><R><F><L><C><G><G><A><L><L><S><G><Q><W><V><I><T><A><A><H><C><G><R><P><I><L><Q><V><A><L><G><K><H><N><L><R><R><W><E><A><T><Q><Q><V><L><R><V><V><R><Q><V><T><H><P><N><Y><N><S><R><T><H><D><N><D><L><M><L><L><Q><L><Q><Q><P><A><R><I><G><R><A><V><R><P><I><E><V><T><Q><A><C><A><S><P><G><T><S><C><R><V><S><G><W><G><T><I><S><S><P><I><A><R><Y><P><A><S><L><Q><C><V><N><I><N><I><S><P><D><E><V><C><Q><K><A><Y><P><R><T><I><T><P><G><M><V><C><A><G><V><P><Q><G><G><K><D><S><C><Q><G><D><S><G><G><P><L><V><C><R><G><Q><L><Q><G><L><V><S><W><G><M><E><R><C><A><L><P><G><Y><P><G><V><Y><T><N><L><C><K><Y><R><S><W><I><E><E><T><M><R><D><K>
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.<BOP>
Q9P0G3
Q12931
TRAP1_HUMAN
Tumor necrosis factor type 1 receptor-associated protein
Homo
<M><A><R><E><L><R><A><L><L><L><W><G><R><R><L><R><P><L><L><R><A><P><A><L><A><A><V><P><G><G><K><P><I><L><C><P><R><R><T><T><A><Q><L><G><P><R><R><N><P><A><W><S><L><Q><A><G><R><L><F><S><T><Q><T><A><E><D><K><E><E><P><L><H><S><I><I><S><S><T><E><S><V><Q><G><S><T><S><K><H><E><F><Q><A><E><T><K><K><L><L><D><I><V><A><R><S><L><Y><S><E><K><E><V><F><I><R><E><L><I><S><N><A><S><D><A><L><E><K><L><R><H><K><L><V><S><D><G><Q><A><L><P><E><M><E><I><H><L><Q><T><N><A><E><K><G><T><I><T><I><Q><D><T><G><I><G><M><T><Q><E><E><L><V><S><N><L><G><T><I><A><R><S><G><S><K><A><F><L><D><A><L><Q><N><Q><A><E><A><S><S><K><I><I><G><Q><F><G><V><G><F><Y><S><A><F><M><V><A><D><R><V><E><V><Y><S><R><S><A><A><P><G><S><L><G><Y><Q><W><L><S><D><G><S><G><V><F><E><I><A><E><A><S><G><V><R><T><G><T><K><I><I><I><H><L><K><S><D><C><K><E><F><S><S><E><A><R><V><R><D><V><V><T><K><Y><S><N><F><V><S><F><P><L><Y><L><N><G><R><R><M><N><T><L><Q><A><I><W><M><M><D><P><K><D><V><R><E><W><Q><H><E><E><F><Y><R><Y><V><A><Q><A><H><D><K><P><R><Y><T><L><H><Y><K><T><D><A><P><L><N><I><R><S><I><F><Y><V><P><D><M><K><P><S><M><F><D><V><S><R><E><L><G><S><S><V><A><L><Y><S><R><K><V><L><I><Q><T><K><A><T><D><I><L><P><K><W><L><R><F><I><R><G><V><V><D><S><E><D><I><P><L><N><L><S><R><E><L><L><Q><E><S><A><L><I><R><K><L><R><D><V><L><Q><Q><R><L><I><K><F><F><I><D><Q><S><K><K><D><A><E><K><Y><A><K><F><F><E><D><Y><G><L><F><M><R><E><G><I><V><T><A><T><E><Q><E><V><K><E><D><I><A><K><L><L><R><Y><E><S><S><A><L><P><S><G><Q><L><T><S><L><S><E><Y><A><S><R><M><R><A><G><T><R><N><I><Y><Y><L><C><A><P><N><R><H><L><A><E><H><S><P><Y><Y><E><A><M><K><K><K><D><T><E><V><L><F><C><F><E><Q><F><D><E><L><T><L><L><H><L><R><E><F><D><K><K><K><L><I><S><V><E><T><D><I><V><V><D><H><Y><K><E><E><K><F><E><D><R><S><P><A><A><E><C><L><S><E><K><E><T><E><E><L><M><A><W><M><R><N><V><L><G><S><R><V><T><N><V><K><V><T><L><R><L><D><T><H><P><A><M><V><T><V><L><E><M><G><A><A><R><H><F><L><R><M><Q><Q><L><A><K><T><Q><E><E><R><A><Q><L><L><Q><P><T><L><E><I><N><P><R><H><A><L><I><K><K><L><N><Q><L><R><A><S><E><P><G><L><A><Q><L><L><V><D><Q><I><Y><E><N><A><M><I><A><A><G><L><V><D><D><P><R><A><M><V><G><R><L><N><E><L><L><V><K><A><L><E><R><H>
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<BOP>
Q12931
A2A3K4
PTPC1_HUMAN
Protein tyrosine phosphatase domain-containing protein 1
Homo
<M><A><A><G><V><L><P><Q><N><E><Q><P><Y><S><T><L><V><N><N><S><E><C><V><A><N><M><K><G><N><L><E><R><P><T><P><K><Y><T><K><V><G><E><R><L><R><H><V><I><P><G><H><M><A><C><S><M><A><C><G><G><R><A><C><K><Y><E><N><P><A><R><W><S><E><Q><E><Q><A><I><K><G><V><Y><S><S><W><V><T><D><N><I><L><A><M><A><R><P><S><S><E><L><L><E><K><Y><H><I><I><D><Q><F><L><S><H><G><I><K><T><I><I><N><L><Q><R><P><G><E><H><A><S><C><G><N><P><L><E><Q><E><S><G><F><T><Y><L><P><E><A><F><M><E><A><G><I><Y><F><Y><N><F><G><W><K><D><Y><G><V><A><S><L><T><T><I><L><D><M><V><K><V><M><T><F><A><L><Q><E><G><K><V><A><I><H><C><H><A><G><L><G><R><T><G><V><L><I><A><C><Y><L><V><F><A><T><R><M><T><A><D><Q><A><I><I><F><V><R><A><K><R><P><N><S><I><Q><T><R><G><Q><L><L><C><V><R><E><F><T><Q><F><L><T><P><L><R><N><I><F><S><C><C><D><P><K><A><H><A><V><T><L><P><Q><Y><L><I><R><Q><R><H><L><L><H><G><Y><E><A><R><L><L><K><H><V><P><K><I><I><H><L><V><C><K><L><L><L><D><L><A><E><N><R><P><V><M><M><K><D><V><S><E><G><P><G><L><S><A><E><I><E><K><T><M><S><E><M><V><T><M><Q><L><D><K><E><L><L><R><H><D><S><D><V><S><N><P><P><N><P><T><A><V><A><A><D><F><D><N><R><G><M><I><F><S><N><E><Q><Q><F><D><P><L><W><K><R><R><N><V><E><C><L><Q><P><L><T><H><L><K><R><R><L><S><Y><S><D><S><D><L><K><R><A><E><N><L><L><E><Q><G><E><T><P><Q><T><V><P><A><Q><I><L><V><G><H><K><P><R><Q><Q><K><L><I><S><H><C><Y><I><P><Q><S><P><E><P><D><L><H><K><E><A><L><V><R><S><T><L><S><F><W><S><Q><S><K><F><G><G><L><E><G><L><K><D><N><G><S><P><I><F><H><G><R><I><I><P><K><E><A><Q><Q><S><G><A><F><S><A><D><V><S><G><S><H><S><P><G><E><P><V><S><P><S><F><A><N><V><H><K><D><P><N><P><A><H><Q><Q><V><S><H><C><Q><C><K><T><H><G><V><G><S><P><G><S><V><R><Q><N><S><R><T><P><R><S><P><L><D><C><G><S><S><P><K><A><Q><F><L><V><E><H><E><T><Q><D><S><K><D><L><S><E><A><A><S><H><S><A><L><Q><S><E><L><S><A><E><A><R><R><I><L><A><A><K><A><L><A><N><L><N><E><S><V><E><K><E><E><L><K><R><K><V><E><M><W><Q><K><E><L><N><S><R><D><G><A><W><E><R><I><C><G><E><R><D><P><F><I><L><C><S><L><M><W><S><W><V><E><Q><L><K><E><P><V><I><T><K><E><D><V><D><M><L><V><D><R><R><A><D><A><A><E><A><L><F><L><L><E><K><G><Q><H><Q><T><I><L><C><V><L><H><C><I><V><N><L><Q><T><I><P><V><D><V><E><E><A><F><L><A><H><A><I><K><A><F><T><K><V><N><F><D><S><E><N><G><P><T><V><Y><N><T><L><K><K><I><F><K><H><T><L><E><E><K><R><K><M><T><K><D><G><P><K><P><G><L>
May play roles in cilia formation and/or maintenance.<BOP>
A2A3K4
Q9ULC4
MCTS1_HUMAN
Multiple copies T-cell malignancies
Homo
<M><F><K><K><F><D><E><K><E><N><V><S><N><C><I><Q><L><K><T><S><V><I><K><G><I><K><N><Q><L><I><E><Q><F><P><G><I><E><P><W><L><N><Q><I><M><P><K><K><D><P><V><K><I><V><R><C><H><E><H><I><E><I><L><T><V><N><G><E><L><L><F><F><R><Q><R><E><G><P><F><Y><P><T><L><R><L><L><H><K><Y><P><F><I><L><P><H><Q><Q><V><D><K><G><A><I><K><F><V><L><S><G><A><N><I><M><C><P><G><L><T><S><P><G><A><K><L><Y><P><A><A><V><D><T><I><V><A><I><M><A><E><G><K><Q><H><A><L><C><V><G><V><M><K><M><S><A><E><D><I><E><K><V><N><K><G><I><G><I><E><N><I><H><Y><L><N><D><G><L><W><H><M><K><T><Y><K>
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall
Q9ULC4
Q9NYW5
TA2R4_HUMAN
Taste receptor type 2 member 4
Homo
<M><L><R><L><F><Y><F><S><A><I><I><A><S><V><I><L><N><F><V><G><I><I><M><N><L><F><I><T><V><V><N><C><K><T><W><V><K><S><H><R><I><S><S><S><D><R><I><L><F><S><L><G><I><T><R><F><L><M><L><G><L><F><L><V><N><T><I><Y><F><V><S><S><N><T><E><R><S><V><Y><L><S><A><F><F><V><L><C><F><M><F><L><D><S><S><S><V><W><F><V><T><L><L><N><I><L><Y><C><V><K><I><T><N><F><Q><H><S><V><F><L><L><L><K><R><N><I><S><P><K><I><P><R><L><L><L><A><C><V><L><I><S><A><F><T><T><C><L><Y><I><T><L><S><Q><A><S><P><F><P><E><L><V><T><T><R><N><N><T><S><F><N><I><S><E><G><I><L><S><L><V><V><S><L><V><L><S><S><S><L><Q><F><I><I><N><V><T><S><A><S><L><L><I><H><S><L><R><R><H><I><Q><K><M><Q><K><N><A><T><G><F><W><N><P><Q><T><E><A><H><V><G><A><M><K><L><M><V><Y><F><L><I><L><Y><I><P><Y><S><V><A><T><L><V><Q><Y><L><P><F><Y><A><G><M><D><M><G><T><K><S><I><C><L><I><F><A><T><L><Y><S><P><G><H><S><V><L><I><I><I><T><H><P><K><L><K><T><T><A><K><K><I><L><C><F><K><K>
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.<BOP>
Q9NYW5
Q5MNV8
FBX47_HUMAN
F-box only protein 47
Homo
<M><A><S><R><I><N><T><N><F><T><L><I><P><N><Q><K><L><R><R><S><N><R><Q><T><S><C><Y><S><K><T><L><G><S><G><F><Q><P><I><S><T><F><G><N><F><K><A><L><P><L><E><I><F><Q><I><I><L><K><Y><L><S><V><K><D><I><S><M><L><S><M><V><S><K><T><V><S><Q><H><I><I><N><Y><I><S><T><S><S><G><S><K><R><L><L><L><Q><D><F><H><N><L><E><L><P><D><R><R><Q><D><S><A><I><L><E><H><Y><R><S><L><G><L><L><F><K><R><C><T><L><L><L><P><T><K><E><R><L><K><Y><I><H><K><I><L><T><E><V><S><C><F><K><F><N><G><C><A><A><P><M><Q><C><L><G><L><T><C><Y><G><M><F><L><Q><T><L><T><A><G><W><D><E><L><E><C><H><R><V><Y><N><F><L><C><E><L><T><N><L><C><R><K><I><Q><M><A><V><C><S><K><P><G><S><A><Q><K><L><E><L><R><I><R><L><F><C><R><N><V><L><L><D><H><W><T><H><R><S><D><S><A><F><W><L><T><R><I><L><K><P><W><P><M><V><N><Q><A><R><L><L><Y><I><I><F><G><P><I><S><P><Q><D><G><Q><V><V><W><Q><E><M><I><E><E><P><T><D><E><F><S><L><K><G><L><A><D><A><I><K><L><L><Y><D><A><S><T><K><E><W><T><A><D><D><V><I><S><L><V><D><E><L><S><V><V><P><R><E><W><L><L><E><N><N><A><R><L><L><M><L><S><G><N><N><I><C><F><S><F><M><A><S><K><A><V><N><G><R><T><I><E><L><A><R><L><V><V><F><L><A><L><V><C><E><K><E><L><Y><C><M><D><W><T><V><K><M><M><Q><K><V><C><K><V><F><S><T><P><V><E><R><K><N><F><L><Q><N><V><A><N><A><F><A><C><V><I><M><E><M><L><Q><S><I><M><S><G><D><R><D><E><D><D><R><S><F><L><N><L><F><H><L><V><H><A><Q><A><N><F><H><K><E><V><L><Y><L><T><M><N><T><P><L><S><T>
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.<BOP>
Q5MNV8
Q9BRS8
LARP6_HUMAN
La ribonucleoprotein domain family member 6
Homo
<M><A><Q><S><G><G><E><A><R><P><G><P><K><T><A><V><Q><I><R><V><A><I><Q><E><A><E><D><V><D><E><L><E><D><E><E><E><G><A><E><T><R><G><A><G><D><P><A><R><Y><L><S><P><G><W><G><S><A><S><E><E><E><P><S><R><G><H><S><G><T><T><A><S><G><G><E><N><E><R><E><D><L><E><Q><E><W><K><P><P><D><E><E><L><I><K><K><L><V><D><Q><I><E><F><Y><F><S><D><E><N><L><E><K><D><A><F><L><L><K><H><V><R><R><N><K><L><G><Y><V><S><V><K><L><L><T><S><F><K><K><V><K><H><L><T><R><D><W><R><T><T><A><H><A><L><K><Y><S><V><V><L><E><L><N><E><D><H><R><K><V><R><R><T><T><P><V><P><L><F><P><N><E><N><L><P><S><K><M><L><L><V><Y><D><L><Y><L><S><P><K><L><W><A><L><A><T><P><Q><K><N><G><R><V><Q><E><K><V><M><E><H><L><L><K><L><F><G><T><F><G><V><I><S><S><V><R><I><L><K><P><G><R><E><L><P><P><D><I><R><R><I><S><S><R><Y><S><Q><V><G><T><Q><E><C><A><I><V><E><F><E><E><V><E><A><A><I><K><A><H><E><F><M><I><T><E><S><Q><G><K><E><N><M><K><A><V><L><I><G><M><K><P><P><K><K><K><P><A><K><D><K><N><H><D><E><E><P><T><A><S><I><H><L><N><K><S><L><N><K><R><V><E><E><L><Q><Y><M><G><D><E><S><S><A><N><S><S><S><D><P><E><S><N><P><T><S><P><M><A><G><R><R><H><A><A><T><N><K><L><S><P><S><G><H><Q><N><L><F><L><S><P><N><A><S><P><C><T><S><P><W><S><S><P><L><A><Q><R><K><G><V><S><R><K><S><P><L><A><E><E><G><R><L><N><C><S><T><S><P><E><I><F><R><K><C><M><D><Y><S><S><D><S><S><V><T><P><S><G><S><P><W><V><R><R><R><R><Q><A><E><M><G><T><Q><E><K><S><P><G><T><S><P><L><L><S><R><K><M><Q><T><A><D><G><L><P><V><G><V><L><R><L><P><R><G><P><D><N><T><R><G><F><H><G><H><E><R><S><R><A><C><V>
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.<BOP>
Q9BRS8
Q9H112
CST11_HUMAN
Cystatin-11
Homo
<M><M><A><E><P><W><Q><A><L><Q><L><L><L><A><I><L><L><T><L><M><A><L><P><Y><Q><A><R><K><K><T><F><L><S><V><H><E><V><M><A><V><E><N><Y><A><K><D><S><L><Q><W><I><T><D><Q><Y><N><K><E><S><D><D><K><Y><H><F><R><I><F><R><V><L><K><V><Q><R><Q><V><T><D><H><L><E><Y><H><L><N><V><E><M><Q><W><T><T><C><Q><K><P><E><T><T><N><C><V><P><Q><E><R><E><L><H><K><Q><V><N><C><F><F><S><V><F><A><V><P><W><F><E><Q><Y><K><I><L><N><K><S><C><S><S><D>
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.<BOP>
Q9H112
P01593
KVD33_HUMAN
Ig kappa chain V-I region WAT
Homo
<M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><S><G><A><R><C><D><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><Q><A><S><Q><D><I><S><N><Y><L><N><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><D><A><S><N><L><E><T><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><F><T><I><S><S><L><Q><P><E><D><I><A><T><Y><Y><C><Q><Q><Y><D><N><L><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P01593
P29762
RABP1_HUMAN
Cellular retinoic acid-binding protein I
Homo
<M><P><N><F><A><G><T><W><K><M><R><S><S><E><N><F><D><E><L><L><K><A><L><G><V><N><A><M><L><R><K><V><A><V><A><A><A><S><K><P><H><V><E><I><R><Q><D><G><D><Q><F><Y><I><K><T><S><T><T><V><R><T><T><E><I><N><F><K><V><G><E><G><F><E><E><E><T><V><D><G><R><K><C><R><S><L><A><T><W><E><N><E><N><K><I><H><C><T><Q><T><L><L><E><G><D><G><P><K><T><Y><W><T><R><E><L><A><N><D><E><L><I><L><T><F><G><A><D><D><V><V><C><T><R><I><Y><V><R><E>
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.<BOP>
P29762
Q9P2B4
CT2NL_HUMAN
CTTNBP2 N-terminal-like protein
Homo
<M><N><L><E><K><L><S><K><P><E><L><L><T><L><F><S><I><L><E><G><E><L><E><A><R><D><L><V><I><E><A><L><K><A><Q><H><R><D><T><F><I><E><E><R><Y><G><K><Y><N><I><S><D><P><L><M><A><L><Q><R><D><F><E><T><L><K><E><K><N><D><G><E><K><Q><P><V><C><T><N><P><L><S><I><L><K><V><V><M><K><Q><C><K><N><M><Q><E><R><M><L><S><Q><L><A><A><A><E><S><R><H><R><K><V><I><L><D><L><E><E><E><R><Q><R><H><A><Q><D><T><A><E><G><D><D><V><T><Y><M><L><E><K><E><R><E><R><L><T><Q><Q><L><E><F><E><K><S><Q><V><K><K><F><E><K><E><Q><K><K><L><S><S><Q><L><E><E><E><R><S><R><H><K><Q><L><S><S><M><L><V><L><E><C><K><K><A><T><N><K><A><A><E><E><G><Q><K><A><G><E><L><S><L><K><L><E><K><E><K><S><R><V><S><K><L><E><E><E><L><A><A><E><R><K><R><G><L><Q><T><E><A><Q><V><E><K><Q><L><S><E><F><D><I><E><R><E><Q><L><R><A><K><L><N><R><E><E><N><R><T><K><T><L><K><E><E><M><E><S><L><K><K><I><V><K><D><L><E><A><S><H><Q><H><S><S><P><N><E><Q><L><K><K><P><V><T><V><S><K><G><T><A><T><E><P><L><M><L><M><S><V><F><C><Q><T><E><S><F><P><A><E><R><T><H><G><S><N><I><A><K><M><T><N><T><G><L><P><G><P><A><T><P><A><Y><S><Y><A><K><T><N><G><H><C><D><P><E><I><Q><T><T><R><E><L><T><A><G><N><N><V><E><N><Q><V><P><P><R><E><K><S><V><A><L><A><Q><E><K><P><V><E><N><G><G><C><P><V><G><I><E><T><P><V><P><M><P><S><P><L><S><S><S><G><S><S><L><S><P><S><S><T><A><S><S><S><L><T><S><S><P><C><S><S><P><V><L><T><K><R><L><L><G><S><S><A><S><S><P><G><Y><Q><S><S><Y><Q><V><G><I><N><Q><R><F><H><A><A><R><H><K><F><Q><S><Q><A><D><Q><D><Q><Q><A><S><G><L><Q><S><P><P><S><R><D><L><S><P><T><L><I><D><N><S><A><A><K><Q><L><A><R><N><T><V><T><Q><V><L><S><R><F><T><S><Q><Q><G><P><I><K><P><V><S><P><N><S><S><P><F><G><T><D><Y><R><N><L><A><N><T><A><N><P><R><G><D><T><S><H><S><P><T><P><G><K><V><S><S><P><L><S><P><L><S><P><G><I><K><S><P><T><I><P><R><A><E><R><G><N><P><P><P><I><P><P><K><K><P><G><L><T><P><S><P><S><A><T><T><P><L><T><K><T><H><S><Q><A><A><S><L><T><T><A><E><D><L><A><S><S><C><S><S><N><T><V><V><A><N><G><K><D><V><E><L><L><L><P><T><S><S>
Regulates lamellipodial actin dynamics in a CTTN-dependent manner.<BOP>
Q9P2B4
A6NP11
ZN716_HUMAN
Zinc finger protein 716
Homo
<M><A><K><R><P><G><P><P><G><S><R><E><M><G><L><L><T><F><R><D><I><A><I><E><F><S><L><A><E><W><Q><C><L><D><H><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><I><A><V><S><K><P><D><L><I><T><C><L><E><Q><N><K><E><P><Q><N><I><K><R><N><E><M><V><A><K><H><P><V><T><C><S><H><F><T><Q><D><L><Q><S><E><Q><G><I><K><D><S><L><Q><K><V><I><L><R><R><Y><G><K><C><G><Q><E><D><L><Q><V><K><K><C><C><K><S><V><G><E><C><E><V><H><K><G><G><Y><N><Y><V><N><Q><C><L><S><A><T><Q><N><K><T><F><Q><T><H><K><C><V><K><V><F><G><K><F><S><N><S><N><R><H><K><T><R><H><T><G><K><K><H><F><K><C><K><N><D><G><K><S><F><C><M><L><S><R><L><N><Q><H><Q><I><I><H><T><R><E><K><S><Y><K><C><E><E><C><G><K><S><F><N><C><S><S><T><L><T><R><H><K><R><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><S><W><S><A><S><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><R><G><K><V><F><S><R><S><T><L><T><N><Y><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><S><R><S><S><T><L><T><N><H><K><R><I><H><T><G><E><R><P><Y><K><C><E><E><C><G><K><A><F><S><L><S><S><T><L><K><K><H><K><I><V><H><T><G><E><K><L><Y><T><C><E><E><C><G><K><A><F><T><F><S><S><T><L><N><T><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><K><A><F><S><L><P><S><T><F><T><Y><H><K><R><T><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><C><S><S><T><L><K><K><H><K><I><I><H><T><G><E><K><L><Y><K><C><K><E><C><G><K><A><F><T><F><S><S><T><L><N><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><D><Q><T><F><K><W><H><S><S><L><A><N><H><K><N><M><H><T><G><E><K><P><Y><K><Y><E>
May be involved in transcriptional regulation.<BOP>
A6NP11
Q96BW9
TAM41_HUMAN
Mitochondrial translocator assembly and maintenance protein 41 homolog
Homo
<M><A><L><Q><T><L><Q><S><S><W><V><T><F><R><K><I><L><S><H><F><P><E><E><L><S><L><A><F><V><Y><G><S><G><V><Y><R><Q><A><G><P><S><S><D><Q><K><N><A><M><L><D><F><V><F><T><V><D><D><P><V><A><W><H><S><K><N><L><K><K><N><W><S><H><Y><S><F><L><K><V><L><G><P><K><I><I><T><S><I><Q><N><N><Y><G><A><G><V><Y><Y><N><S><L><I><M><C><N><G><R><L><I><K><Y><G><V><I><S><T><N><V><L><I><E><D><L><L><N><W><N><N><L><Y><I><A><G><R><L><Q><K><P><V><K><I><I><S><V><N><E><D><V><T><L><R><S><A><L><D><R><N><L><K><S><A><V><T><A><A><F><L><M><L><P><E><S><F><S><E><E><D><L><F><I><E><I><A><G><L><S><Y><S><G><D><F><R><M><V><V><G><E><D><K><T><K><V><L><N><I><V><K><P><N><I><A><H><F><R><E><L><Y><G><S><I><L><Q><E><N><P><Q><V><V><Y><K><S><Q><Q><G><W><L><E><I><D><K><S><P><E><G><Q><F><T><Q><L><M><T><L><P><K><T><L><Q><Q><Q><I><N><H><I><M><D><P><P><G><K><N><R><D><V><E><E><T><L><F><Q><V><A><H><D><P><D><C><G><D><V><V><R><L><G><L><S><A><I><V><R><P><S><S><I><R><Q><S><T><K><G><I><F><T><A><G><K><S><F><G><N><P><C><V><T><Y><L><L><T><E><W><L><P><H><S><W><L><Q><C><K><A><L><Y><L><L><G><A><C><E><M><L><S><F><D><G><H><K><L><G><Y><C><S><K><V><Q><T><G><I><T><A><A><E><P><G><G><R><T><M><S><D><H><W><Q><C><C><W><K><L><Y><C><P><S><E><F><S><E><T><L><P><V><C><R><V><F><P><S><Y><C><F><I><Y><Q><S><Y><R><C><I><G><L><Q><K><Q><Q><H><L><C><S><P><S><S><S><P><S><L><R><Q><L><L><P><S><V><L><V><G><Y><F><C><C><Y><C><H><F><S><K><W>
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.<BOP>
Q96BW9
Q7L804
RFIP2_HUMAN
NRip11
Homo
<M><M><L><S><E><Q><A><Q><K><W><F><P><T><H><V><Q><V><T><V><L><Q><A><K><D><L><K><P><K><G><K><S><G><T><N><D><T><Y><T><I><I><Q><L><G><K><E><K><Y><S><T><S><V><A><E><K><T><L><E><P><V><W><K><E><E><A><S><F><E><L><P><G><L><L><I><Q><G><S><P><E><K><Y><I><L><F><L><I><V><M><H><R><S><L><V><G><L><D><K><F><L><G><Q><V><A><I><N><L><N><D><I><F><E><D><K><Q><R><R><K><T><E><W><F><R><L><E><S><K><Q><G><K><R><I><K><N><R><G><E><I><K><V><N><I><Q><F><M><R><N><N><M><T><A><S><M><F><D><L><S><M><K><D><K><T><R><S><P><F><A><K><L><K><D><K><M><K><G><R><K><N><D><G><T><F><S><D><T><S><S><A><I><I><P><S><T><H><M><P><D><A><N><S><E><F><S><S><G><E><I><Q><M><K><S><K><P><K><K><P><F><L><L><G><P><Q><R><L><S><S><A><H><S><M><S><D><L><S><G><S><H><M><S><S><E><K><L><K><A><G><T><I><G><Q><T><H><L><L><G><H><Q><L><D><S><F><G><T><V><P><E><S><G><S><L><K><S><P><H><R><R><T><L><S><F><D><T><S><K><M><N><Q><P><D><S><I><V><D><E><G><E><L><C><F><G><R><Q><N><D><P><F><T><N><V><T><A><S><L><P><Q><K><F><A><T><L><P><R><K><K><N><P><F><E><E><S><S><E><T><W><D><S><S><M><N><L><F><S><K><P><I><E><I><R><K><E><N><K><R><E><K><R><E><K><V><S><L><F><E><R><V><T><G><K><K><D><S><R><R><S><D><K><L><N><N><G><G><S><D><S><P><C><D><L><K><S><P><N><A><F><S><E><N><R><Q><D><Y><F><D><Y><E><S><T><N><P><F><T><A><K><F><R><A><S><N><I><M><P><S><S><S><F><H><M><S><P><T><S><N><E><D><L><R><K><I><P><D><S><N><P><F><D><A><T><A><G><Y><R><S><L><T><Y><E><E><V><L><Q><E><L><V><K><H><K><E><L><L><R><R><K><D><T><H><I><R><E><L><E><D><Y><I><D><N><L><L><V><R><V><M><E><E><T><P><S><I><L><R><V><P><Y><E><P><S><R><K><A><G><K><F><S><N><S>
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.<BOP>
Q7L804
Q8NGK2
O52B4_HUMAN
Olfactory receptor OR11-3
Homo
<M><P><T><V><N><H><S><G><T><S><H><T><V><F><H><L><L><G><I><P><G><L><Q><D><Q><H><M><W><I><S><I><P><F><F><I><S><Y><V><T><A><L><L><G><N><S><L><L><I><F><I><I><L><T><K><R><S><L><H><E><P><M><Y><L><F><L><C><M><L><A><G><A><D><I><V><L><S><T><C><T><I><P><Q><A><L><A><I><F><W><F><R><A><G><D><I><S><L><D><R><C><I><T><Q><L><F><F><I><H><S><T><F><I><S><E><S><G><I><L><L><V><M><A><F><D><H><Y><I><A><I><C><Y><P><L><R><Y><T><T><I><L><T><N><A><L><I><K><K><I><C><V><T><V><S><L><R><S><Y><G><T><I><F><P><I><I><F><L><L><K><R><L><T><F><C><Q><N><N><I><I><P><H><T><F><C><E><H><I><G><L><A><K><Y><A><C><N><D><I><R><I><N><I><W><Y><G><F><S><I><L><M><S><T><V><V><L><D><V><V><L><I><F><I><S><Y><M><L><I><L><H><A><V><F><H><M><P><S><P><D><A><C><H><K><A><L><N><T><F><G><S><H><V><C><I><I><I><L><F><Y><G><S><G><I><F><T><I><L><T><Q><R><F><G><R><H><I><P><P><C><I><H><I><P><L><A><N><V><C><I><L><A><P><P><M><L><N><P><I><I><Y><G><I><K><T><K><Q><I><Q><E><Q><V><V><Q><F><L><F><I><K><Q><K>
Odorant receptor.<BOP>
Q8NGK2
Q8TDE3
RNAS8_HUMAN
Ribonuclease 8
Homo
<M><A><P><A><R><A><G><C><C><P><L><L><L><L><L><L><G><L><W><V><A><E><V><L><V><R><A><K><P><K><D><M><T><S><S><Q><W><F><K><T><Q><H><V><Q><P><S><P><Q><A><C><N><S><A><M><S><I><I><N><K><Y><T><E><R><C><K><D><L><N><T><F><L><H><E><P><F><S><S><V><A><I><T><C><Q><T><P><N><I><A><C><K><N><S><C><K><N><C><H><Q><S><H><G><P><M><S><L><T><M><G><E><L><T><S><G><K><Y><P><N><C><R><Y><K><E><K><H><L><N><T><P><Y><I><V><A><C><D><P><P><Q><Q><G><D><P><G><Y><P><L><V><P><V><H><L><D><K><V><V>
Has a low ribonuclease activity.<BOP>
Q8TDE3
Q9Y697
NFS1_HUMAN
Cysteine desulfurase, mitochondrial
Homo
<M><L><L><R><A><A><W><R><R><A><A><V><A><V><T><A><A><P><G><P><K><P><A><A><P><T><R><G><L><R><L><R><V><G><D><R><A><P><Q><S><A><V><P><A><D><T><A><A><A><P><E><V><G><P><V><L><R><P><L><Y><M><D><V><Q><A><T><T><P><L><D><P><R><V><L><D><A><M><L><P><Y><L><I><N><Y><Y><G><N><P><H><S><R><T><H><A><Y><G><W><E><S><E><A><A><M><E><R><A><R><Q><Q><V><A><S><L><I><G><A><D><P><R><E><I><I><F><T><S><G><A><T><E><S><N><N><I><A><I><K><G><V><A><R><F><Y><R><S><R><K><K><H><L><I><T><T><Q><T><E><H><K><C><V><L><D><S><C><R><S><L><E><A><E><G><F><Q><V><T><Y><L><P><V><Q><K><S><G><I><I><D><L><K><E><L><E><A><A><I><Q><P><D><T><S><L><V><S><V><M><T><V><N><N><E><I><G><V><K><Q><P><I><A><E><I><G><R><I><C><S><S><R><K><V><Y><F><H><T><D><A><A><Q><A><V><G><K><I><P><L><D><V><N><D><M><K><I><D><L><M><S><I><S><G><H><K><I><Y><G><P><K><G><V><G><A><I><Y><I><R><R><R><P><R><V><R><V><E><A><L><Q><S><G><G><G><Q><E><R><G><M><R><S><G><T><V><P><T><P><L><V><V><G><L><G><A><A><C><E><V><A><Q><Q><E><M><E><Y><D><H><K><R><I><S><K><L><S><E><R><L><I><Q><N><I><M><K><S><L><P><D><V><V><M><N><G><D><P><K><H><H><Y><P><G><C><I><N><L><S><F><A><Y><V><E><G><E><S><L><L><M><A><L><K><D><V><A><L><S><S><G><S><A><C><T><S><A><S><L><E><P><S><Y><V><L><R><A><I><G><T><D><E><D><L><A><H><S><S><I><R><F><G><I><G><R><F><T><T><E><E><E><V><D><Y><T><V><E><K><C><I><Q><H><V><K><R><L><R><E><M><S><P><L><W><E><M><V><Q><D><G><I><D><L><K><S><I><K><W><T><Q><H>
Catalyzes the removal of elemental sulfur from cysteine to produce alanine . It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor .<BOP>
Q9Y697
Q8IUW5
RELL1_HUMAN
RELT-like protein 1
Homo
<M><A><P><R><A><L><P><G><S><A><V><L><A><A><A><V><F><V><G><G><A><V><S><S><P><L><V><A><P><D><N><G><S><S><R><T><L><H><S><R><T><E><T><T><P><S><P><S><N><D><T><G><N><G><H><P><E><Y><I><A><Y><A><L><V><P><V><F><F><I><M><G><L><F><G><V><L><I><C><H><L><L><K><K><K><G><Y><R><C><T><T><E><A><E><Q><D><I><E><E><E><K><V><E><K><I><E><L><N><D><S><V><N><E><N><S><D><T><V><G><Q><I><V><H><Y><I><M><K><N><E><A><N><A><D><V><L><K><A><M><V><A><D><N><S><L><Y><D><P><E><S><P><V><T><P><S><T><P><G><S><P><P><V><S><P><G><P><L><S><P><G><G><T><P><G><K><H><V><C><G><H><H><L><H><T><V><G><G><V><V><E><R><D><V><C><H><R><C><R><H><K><R><W><H><F><I><K><P><T><N><K><S><R><E><S><R><P><R><R><Q><G><E><V><T><V><L><S><V><G><R><F><R><V><T><K><V><E><H><K><S><N><Q><K><E><R><R><S><L><M><S><V><S><G><A><E><T><V><N><G><E><V><P><A><T><P><V><K><R><E><R><S><G><T><E>
Induces activation of MAPK14/p38 cascade, when overexpressed . Induces apoptosis, when overexpressed .<BOP>
Q8IUW5
Q8WWT9
S13A3_HUMAN
Solute carrier family 13 member 3
Homo
<M><A><A><L><A><A><A><A><K><K><V><W><S><A><R><R><L><L><V><L><L><F><T><P><L><A><L><L><P><V><V><F><A><L><P><P><K><E><G><R><C><L><F><V><I><L><L><M><A><V><Y><W><C><T><E><A><L><P><L><S><V><T><A><L><L><P><I><V><L><F><P><F><M><G><I><L><P><S><N><K><V><C><P><Q><Y><F><L><D><T><N><F><L><F><L><S><G><L><I><M><A><S><A><I><E><E><W><N><L><H><R><R><I><A><L><K><I><L><M><L><V><G><V><Q><P><A><R><L><I><L><G><M><M><V><T><T><S><F><L><S><M><W><L><S><N><T><A><S><T><A><M><M><L><P><I><A><N><A><I><L><K><S><L><F><G><Q><K><E><V><R><K><D><P><S><Q><E><S><E><E><N><T><A><A><V><R><R><N><G><L><H><T><V><P><T><E><M><Q><F><L><A><S><T><E><A><K><D><H><P><G><E><T><E><V><P><L><D><L><P><A><D><S><R><K><E><D><E><Y><R><R><N><I><W><K><G><F><L><I><S><I><P><Y><S><A><S><I><G><G><T><A><T><L><T><G><T><A><P><N><L><I><L><L><G><Q><L><K><S><F><F><P><Q><C><D><V><V><N><F><G><S><W><F><I><F><A><F><P><L><M><L><L><F><L><L><A><G><W><L><W><I><S><F><L><Y><G><G><L><S><F><R><G><W><R><K><N><K><S><E><I><R><T><N><A><E><D><R><A><R><A><V><I><R><E><E><Y><Q><N><L><G><P><I><K><F><A><E><Q><A><V><F><I><L><F><C><M><F><A><I><L><L><F><T><R><D><P><K><F><I><P><G><W><A><S><L><F><N><P><G><F><L><S><D><A><V><T><G><V><A><I><V><T><I><L><F><F><F><P><S><Q><R><P><S><L><K><W><W><F><D><F><K><A><P><N><T><E><T><E><P><L><L><T><W><K><K><A><Q><E><T><V><P><W><N><I><I><L><L><L><G><G><G><F><A><M><A><K><G><C><E><E><S><G><L><S><V><W><I><G><G><Q><L><H><P><L><E><N><V><P><P><A><L><A><V><L><L><I><T><V><V><I><A><F><F><T><E><F><A><S><N><T><A><T><I><I><I><F><L><P><V><L><A><E><L><A><I><R><L><R><V><H><P><L><Y><L><M><I><P><G><T><V><G><C><S><F><A><F><M><L><P><V><S><T><P><P><N><S><I><A><F><A><S><G><H><L><L><V><K><D><M><V><R><T><G><L><L><M><N><L><M><G><V><L><L><L><S><L><A><M><N><T><W><A><Q><T><I><F><Q><L><G><T><F><P><D><W><A><D><M><Y><S><V><N><V><T><A><L><P><P><T><L><A><N><D><T><F><R><T><L>
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate . Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic . Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood .<BOP>
Q8WWT9
Q9GZK6
OR2J1_HUMAN
Olfactory receptor 6-5
Homo
<M><L><M><K><K><N><A><S><F><E><D><F><F><L><L><L><G><F><S><N><W><P><H><L><E><V><V><L><F><V><V><I><L><I><F><Y><L><I><T><L><I><G><N><L><F><I><I><I><L><S><Y><L><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><L><D><L><C><Y><T><T><S><S><I><P><Q><L><L><V><N><L><W><G><P><E><K><T><I><S><Y><A><G><C><T><V><Q><L><Y><F><V><L><A><L><G><T><A><E><C><V><L><L><V><V><M><S><Y><D><R><Y><A><A><V><C><R><P><L><H><Y><T><V><L><M><H><P><R><F><C><R><L><L><A><A><A><S><W><V><S><G><F><T><T><S><A><L><H><S><S><F><T><F><W><I><P><L><C><R><H><R><L><V><D><H><F><F><C><E><V><P><A><L><L><R><L><S><C><V><D><T><Q><A><N><E><L><T><L><M><V><M><S><S><I><F><V><L><I><P><L><I><L><I><L><T><S><Y><G><A><I><A><R><A><V><L><S><M><Q><S><T><T><G><L><Q><K><V><L><R><T><C><G><A><H><L><M><V><V><S><L><F><F><I><P><V><M><C><M><Y><L><Q><P><P><S><E><N><S><Q><D><Q><G><K><F><I><A><L><F><Y><T><V><V><T><P><S><L><N><P><L><I><Y><T><F><R><N><K><D><V><R><G><A><V><K><R><L><M><G><W><E><W><G><M>
Odorant receptor.<BOP>
Q9GZK6
Q99501
GA2L1_HUMAN
Growth arrest-specific protein 2-like 1
Homo
<M><A><D><P><V><A><G><I><A><G><S><A><A><K><S><V><R><P><F><R><S><S><E><A><Y><V><E><A><M><K><E><D><L><A><E><W><L><N><A><L><Y><G><L><G><L><P><G><G><G><D><G><F><L><T><G><L><A><T><G><T><T><L><C><Q><H><A><N><A><V><T><E><A><A><R><A><L><A><A><A><R><P><A><R><G><V><A><F><Q><A><H><S><V><V><P><G><S><F><M><A><R><D><N><V><A><T><F><I><G><W><C><R><V><E><L><G><V><P><E><V><L><M><F><E><T><E><D><L><V><L><R><K><N><E><K><S><V><V><L><C><L><L><E><V><A><R><R><G><A><R><L><G><L><L><A><P><R><L><V><Q><F><E><Q><E><I><E><R><E><L><R><A><A><P><P><A><P><N><A><P><A><A><G><E><D><T><T><E><T><A><P><A><P><G><T><P><A><R><G><P><R><M><T><P><S><D><L><R><N><L><D><E><L><V><R><E><I><L><G><R><C><T><C><P><D><Q><F><P><M><I><K><V><S><E><G><K><Y><R><V><G><D><S><S><L><L><I><F><V><R><V><L><R><S><H><V><M><V><R><V><G><G><G><W><D><T><L><E><H><Y><L><D><K><H><D><P><C><R><C><S><S><T><A><H><R><P><P><Q><P><R><V><C><T><F><S><P><Q><R><V><S><P><T><T><S><P><R><P><A><S><P><V><P><G><S><E><R><R><G><S><R><P><E><M><T><P><V><S><L><R><S><T><K><E><G><P><E><T><P><P><R><P><R><D><Q><L><P><P><H><P><R><S><R><R><Y><S><G><D><S><D><S><S><A><S><S><A><Q><S><G><P><L><G><T><R><S><D><D><T><G><T><G><P><R><R><E><R><P><S><R><R><L><T><T><G><T><P><A><S><P><R><R><P><P><A><L><R><S><Q><S><R><D><R><L><D><R><G><R><P><R><G><A><P><G><G><R><G><A><Q><L><S><V><P><S><P><A><R><R><A><R><S><Q><S><R><E><E><Q><A><V><L><L><V><R><R><D><R><D><G><Q><H><S><W><V><P><R><G><R><G><S><G><G><S><G><R><S><T><P><Q><T><P><R><A><R><S><P><A><A><P><R><L><S><R><V><S><S><P><S><P><E><L><G><T><T><P><A><S><I><F><R><T><P><L><Q><L><D><P><Q><Q><E><Q><Q><L><F><R><R><L><E><E><E><F><L><A><N><A><R><A><L><E><A><V><A><S><V><T><P><T><G><P><V><P><D><P><A><R><A><P><D><P><P><A><P><D><S><A><Y><C><S><S><S><S><S><S><S><S><L><S><V><L><G><G><K><C><G><Q><P><G><D><S><G><R><T><A><N><G><L><P><G><P><R><S><Q><A><L><S><S><S><S><D><E><G><S><P><C><P><G><M><G><G><P><L><D><A><P><G><S><P><L><A><C><T><E><P><S><R><T><W><A><R><G><R><M><D><T><Q><P><D><R><K><P><S><R><I><P><T><P><R><G><P><R><R><P><S><G><P><A><E><L><G><T><W><H><A><L><H><S><V><T><P><R><A><E><P><D><S><W><M>
Involved in the cross-linking of microtubules and microfilaments . Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers .<BOP>
Q99501
Q15084
PDIA6_HUMAN
Thioredoxin domain-containing protein 7
Homo
<M><A><L><L><V><L><G><L><V><S><C><T><F><F><L><A><V><N><G><L><Y><S><S><S><D><D><V><I><E><L><T><P><S><N><F><N><R><E><V><I><Q><S><D><S><L><W><L><V><E><F><Y><A><P><W><C><G><H><C><Q><R><L><T><P><E><W><K><K><A><A><T><A><L><K><D><V><V><K><V><G><A><V><D><A><D><K><H><H><S><L><G><G><Q><Y><G><V><Q><G><F><P><T><I><K><I><F><G><S><N><K><N><R><P><E><D><Y><Q><G><G><R><T><G><E><A><I><V><D><A><A><L><S><A><L><R><Q><L><V><K><D><R><L><G><G><R><S><G><G><Y><S><S><G><K><Q><G><R><S><D><S><S><S><K><K><D><V><I><E><L><T><D><D><S><F><D><K><N><V><L><D><S><E><D><V><W><M><V><E><F><Y><A><P><W><C><G><H><C><K><N><L><E><P><E><W><A><A><A><A><S><E><V><K><E><Q><T><K><G><K><V><K><L><A><A><V><D><A><T><V><N><Q><V><L><A><S><R><Y><G><I><R><G><F><P><T><I><K><I><F><Q><K><G><E><S><P><V><D><Y><D><G><G><R><T><R><S><D><I><V><S><R><A><L><D><L><F><S><D><N><A><P><P><P><E><L><L><E><I><I><N><E><D><I><A><K><R><T><C><E><E><H><Q><L><C><V><V><A><V><L><P><H><I><L><D><T><G><A><A><G><R><N><S><Y><L><E><V><L><L><K><L><A><D><K><Y><K><K><K><M><W><G><W><L><W><T><E><A><G><A><Q><S><E><L><E><T><A><L><G><I><G><G><F><G><Y><P><A><M><A><A><I><N><A><R><K><M><K><F><A><L><L><K><G><S><F><S><E><Q><G><I><N><E><F><L><R><E><L><S><F><G><R><G><S><T><A><P><V><G><G><G><A><F><P><T><I><V><E><R><E><P><W><D><G><R><D><G><E><L><P><V><E><D><D><I><D><L><S><D><V><E><L><D><D><L><G><K><D><E><L>
May function as a chaperone that inhibits aggregation of misfolded proteins . Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling . May also regulate the UPR via the EIF2AK3 UPR sensor . Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin .<BOP>
Q15084
Q5VWP2
TET5C_HUMAN
Non-canonical poly(A) polymerase FAM46C
Homo
<M><A><E><E><S><S><C><T><R><D><C><M><S><F><S><V><L><N><W><D><Q><V><S><R><L><H><E><V><L><T><E><V><V><P><I><H><G><R><G><N><F><P><T><L><E><I><T><L><K><D><I><V><Q><T><V><R><S><R><L><E><E><A><G><I><K><V><H><D><V><R><L><N><G><S><A><A><G><H><V><L><V><K><D><N><G><L><G><C><K><D><L><D><L><I><F><H><V><A><L><P><T><E><A><E><F><Q><L><V><R><D><V><V><L><C><S><L><L><N><F><L><P><E><G><V><N><K><L><K><I><S><P><V><T><L><K><E><A><Y><V><Q><K><L><V><K><V><C><T><D><T><D><R><W><S><L><I><S><L><S><N><K><N><G><K><N><V><E><L><K><F><V><D><S><I><R><R><Q><F><E><F><S><V><D><S><F><Q><I><I><L><D><S><L><L><F><F><Y><D><C><S><N><N><P><I><S><E><H><F><H><P><T><V><I><G><E><S><M><Y><G><D><F><E><E><A><F><D><H><L><Q><N><R><L><I><A><T><K><N><P><E><E><I><R><G><G><G><L><L><K><Y><S><N><L><L><V><R><D><F><R><P><T><D><Q><E><E><I><K><T><L><E><R><Y><M><C><S><R><F><F><I><D><F><P><D><I><L><E><Q><Q><R><K><L><E><T><Y><L><Q><N><H><F><A><E><E><E><R><S><K><Y><D><Y><L><M><I><L><R><R><V><V><N><E><S><T><V><C><L><M><G><H><E><R><R><Q><T><L><N><L><I><S><L><L><A><L><R><V><L><A><E><Q><N><I><I><P><S><A><T><N><V><T><C><Y><Y><Q><P><A><P><Y><V><S><D><G><N><F><S><N><Y><Y><V><A><H><P><P><V><T><Y><S><Q><P><Y><P><T><W><L><P><C><N>
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.<BOP>
Q5VWP2
Q9UIL1
SCOC_HUMAN
Short coiled-coil protein
Homo
<M><R><R><R><V><F><S><S><Q><D><W><R><A><S><G><W><D><G><M><G><F><F><S><R><R><T><F><C><G><R><S><G><R><S><C><R><G><Q><L><V><Q><V><S><R><P><E><V><S><A><G><S><L><L><L><P><A><P><Q><A><E><D><H><S><S><R><I><L><Y><P><R><P><K><S><L><L><P><K><M><M><N><A><D><M><D><A><V><D><A><E><N><Q><V><E><L><E><E><K><T><R><L><I><N><Q><V><L><E><L><Q><H><T><L><E><D><L><S><A><R><V><D><A><V><K><E><E><N><L><K><L><K><S><E><N><Q><V><L><G><Q><Y><I><E><N><L><M><S><A><S><S><V><F><Q><T><T><D><T><K><S><K><R><K>
Positive regulator of amino acid starvation-induced autophagy.<BOP>
Q9UIL1
Q6NSJ0
MYORG_HUMAN
Uncharacterized family 31 glucosidase KIAA1161
Homo
<M><L><Q><N><P><Q><E><K><S><Q><A><Y><P><R><R><R><R><P><G><C><Y><A><Y><R><Q><N><P><E><A><I><A><A><A><A><M><Y><T><F><L><P><D><N><F><S><P><A><K><P><K><P><S><K><D><L><K><P><L><L><G><S><A><V><L><G><L><L><L><V><L><A><A><V><V><A><W><C><Y><Y><S><V><S><L><R><K><A><E><R><L><R><A><E><L><L><D><L><K><A><G><G><F><S><I><R><N><Q><K><G><E><Q><V><F><R><L><A><F><R><S><G><A><L><D><L><D><S><C><S><R><D><G><A><L><L><G><C><S><L><T><A><D><G><L><P><L><H><F><F><I><Q><T><V><R><P><K><D><T><V><M><C><Y><R><V><R><W><E><E><A><A><P><G><R><A><V><E><H><A><M><F><L><G><D><A><A><A><H><W><Y><G><G><A><E><M><R><T><Q><H><W><P><I><R><L><D><G><Q><Q><E><P><Q><P><F><V><T><S><D><V><Y><S><S><D><A><A><F><G><G><I><L><E><R><Y><W><L><S><S><R><A><A><A><I><K><V><N><D><S><V><P><F><H><L><G><W><N><S><T><E><R><S><L><R><L><Q><A><R><Y><H><D><T><P><Y><K><P><P><A><G><R><A><A><A><P><E><L><S><Y><R><V><C><V><G><S><D><V><T><S><I><H><K><Y><M><V><R><R><Y><F><N><K><P><S><R><V><P><A><P><E><A><F><R><D><P><I><W><S><T><W><A><L><Y><G><R><A><V><D><Q><D><K><V><L><R><F><A><Q><Q><I><R><L><H><H><F><N><S><S><H><L><E><I><D><D><M><Y><T><P><A><Y><G><D><F><D><F><D><E><V><K><F><P><N><A><S><D><M><F><R><R><L><R><D><A><G><F><R><V><T><L><W><V><H><P><F><V><N><Y><N><S><S><R><F><G><E><G><V><E><R><E><L><F><V><R><E><P><T><G><R><L><P><A><L><V><R><W><W><N><G><I><G><A><V><L><D><F><T><H><P><K><A><R><D><W><F><Q><G><H><L><R><R><L><R><S><R><Y><S><V><A><S><F><K><F><D><A><G><E><V><S><Y><L><P><R><D><F><S><T><Y><R><P><L><P><D><P><S><V><W><S><R><R><Y><T><E><M><A><L><P><F><F><S><L><A><E><V><R><V><G><Y><Q><S><Q><N><I><S><C><F><F><R><L><V><D><R><D><S><V><W><G><Y><D><L><G><L><R><S><L><I><P><A><V><L><T><V><S><M><L><G><Y><P><F><I><L><P><D><M><V><G><G><N><A><V><P><Q><R><T><A><G><G><D><V><P><E><R><E><L><Y><I><R><W><L><E><V><A><A><F><M><P><A><M><Q><F><S><I><P><P><W><R><Y><D><A><E><V><V><A><I><A><Q><K><F><A><A><L><R><A><S><L><V><A><P><L><L><L><E><L><A><G><E><V><T><D><T><G><D><P><I><V><R><P><L><W><W><I><A><P><G><D><E><T><A><H><R><I><D><S><Q><F><L><I><G><D><T><L><L><V><A><P><V><L><E><P><G><K><Q><E><R><D><V><Y><L><P><A><G><K><W><R><S><Y><K><G><E><L><F><D><K><T><P><V><L><L><T><D><Y><P><V><D><L><D><E><I><A><Y><F><T><W><A><S>
Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2.<BOP>
Q6NSJ0
Q05516
ZBT16_HUMAN
Zinc finger protein PLZF
Homo
<M><D><L><T><K><M><G><M><I><Q><L><Q><N><P><S><H><P><T><G><L><L><C><K><A><N><Q><M><R><L><A><G><T><L><C><D><V><V><I><M><V><D><S><Q><E><F><H><A><H><R><T><V><L><A><C><T><S><K><M><F><E><I><L><F><H><R><N><S><Q><H><Y><T><L><D><F><L><S><P><K><T><F><Q><Q><I><L><E><Y><A><Y><T><A><T><L><Q><A><K><A><E><D><L><D><D><L><L><Y><A><A><E><I><L><E><I><E><Y><L><E><E><Q><C><L><K><M><L><E><T><I><Q><A><S><D><D><N><D><T><E><A><T><M><A><D><G><G><A><E><E><E><E><D><R><K><A><R><Y><L><K><N><I><F><I><S><K><H><S><S><E><E><S><G><Y><A><S><V><A><G><Q><S><L><P><G><P><M><V><D><Q><S><P><S><V><S><T><S><F><G><L><S><A><M><S><P><T><K><A><A><V><D><S><L><M><T><I><G><Q><S><L><L><Q><G><T><L><Q><P><P><A><G><P><E><E><P><T><L><A><G><G><G><R><H><P><G><V><A><E><V><K><T><E><M><M><Q><V><D><E><V><P><S><Q><D><S><P><G><A><A><E><S><S><I><S><G><G><M><G><D><K><V><E><E><R><G><K><E><G><P><G><T><P><T><R><S><S><V><I><T><S><A><R><E><L><H><Y><G><R><E><E><S><A><E><Q><V><P><P><P><A><E><A><G><Q><A><P><T><G><R><P><E><H><P><A><P><P><P><E><K><H><L><G><I><Y><S><V><L><P><N><H><K><A><D><A><V><L><S><M><P><S><S><V><T><S><G><L><H><V><Q><P><A><L><A><V><S><M><D><F><S><T><Y><G><G><L><L><P><Q><G><F><I><Q><R><E><L><F><S><K><L><G><E><L><A><V><G><M><K><S><E><S><R><T><I><G><E><Q><C><S><V><C><G><V><E><L><P><D><N><E><A><V><E><Q><H><R><K><L><H><S><G><M><K><T><Y><G><C><E><L><C><G><K><R><F><L><D><S><L><R><L><R><M><H><L><L><A><H><S><A><G><A><K><A><F><V><C><D><Q><C><G><A><Q><F><S><K><E><D><A><L><E><T><H><R><Q><T><H><T><G><T><D><M><A><V><F><C><L><L><C><G><K><R><F><Q><A><Q><S><A><L><Q><Q><H><M><E><V><H><A><G><V><R><S><Y><I><C><S><E><C><N><R><T><F><P><S><H><T><A><L><K><R><H><L><R><S><H><T><G><D><H><P><Y><E><C><E><F><C><G><S><C><F><R><D><E><S><T><L><K><S><H><K><R><I><H><T><G><E><K><P><Y><E><C><N><G><C><G><K><K><F><S><L><K><H><Q><L><E><T><H><Y><R><V><H><T><G><E><K><P><F><E><C><K><L><C><H><Q><R><S><R><D><Y><S><A><M><I><K><H><L><R><T><H><N><G><A><S><P><Y><Q><C><T><I><C><T><E><Y><C><P><S><L><S><S><M><Q><K><H><M><K><G><H><K><P><E><E><I><P><P><D><W><R><I><E><K><T><Y><L><Y><L><C><Y><V>
Acts as a transcriptional repressor . Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters . May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins .<BOP>
Q05516
P0C862
C1T9A_HUMAN
Complement C1q and tumor necrosis factor-related protein 9
Homo
<M><R><I><W><W><L><L><L><A><I><E><I><C><T><G><N><I><N><S><Q><D><T><C><R><Q><G><H><P><G><I><P><G><N><P><G><H><N><G><L><P><G><R><D><G><R><D><G><A><K><G><D><K><G><D><A><G><E><P><G><R><P><G><S><P><G><K><D><G><T><S><G><E><K><G><E><R><G><A><D><G><K><V><E><A><K><G><I><K><G><D><Q><G><S><R><G><S><P><G><K><H><G><P><K><G><L><A><G><P><M><G><E><K><G><L><R><G><E><T><G><P><Q><G><Q><K><G><N><K><G><D><V><G><P><T><G><P><E><G><P><R><G><N><I><G><P><L><G><P><T><G><L><P><G><P><M><G><P><I><G><K><P><G><P><K><G><E><A><G><P><T><G><P><Q><G><E><P><G><V><R><G><I><R><G><W><K><G><D><R><G><E><K><G><K><I><G><E><T><L><V><L><P><K><S><A><F><T><V><G><L><T><V><L><S><K><F><P><S><S><D><M><P><I><K><F><D><K><I><L><Y><N><E><F><N><H><Y><D><T><A><A><G><K><F><T><C><H><I><A><G><V><Y><Y><F><T><Y><H><I><T><V><F><S><R><N><V><Q><V><S><L><V><K><N><G><V><K><I><L><H><T><K><D><A><Y><M><S><S><E><D><Q><A><S><G><G><I><V><L><Q><L><K><L><G><D><E><V><W><L><Q><V><T><G><G><E><R><F><N><G><L><F><A><D><E><D><D><D><T><T><F><T><G><F><L><L><F><S><S><P>
Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.<BOP>
P0C862
Q9UBF1
MAGC2_HUMAN
MAGE-E1 antigen
Homo
<M><P><P><V><P><G><V><P><F><R><N><V><D><N><D><S><P><T><S><V><E><L><E><D><W><V><D><A><Q><H><P><T><D><E><E><E><E><E><A><S><S><A><S><S><T><L><Y><L><V><F><S><P><S><S><F><S><T><S><S><S><L><I><L><G><G><P><E><E><E><E><V><P><S><G><V><I><P><N><L><T><E><S><I><P><S><S><P><P><Q><G><P><P><Q><G><P><S><Q><S><P><L><S><S><C><C><S><S><F><S><W><S><S><F><S><E><E><S><S><S><Q><K><G><E><D><T><G><T><C><Q><G><L><P><D><S><E><S><S><F><T><Y><T><L><D><E><K><V><A><E><L><V><E><F><L><L><L><K><Y><E><A><E><E><P><V><T><E><A><E><M><L><M><I><V><I><K><Y><K><D><Y><F><P><V><I><L><K><R><A><R><E><F><M><E><L><L><F><G><L><A><L><I><E><V><G><P><D><H><F><C><V><F><A><N><T><V><G><L><T><D><E><G><S><D><D><E><G><M><P><E><N><S><L><L><I><I><I><L><S><V><I><F><I><K><G><N><C><A><S><E><E><V><I><W><E><V><L><N><A><V><G><V><Y><A><G><R><E><H><F><V><Y><G><E><P><R><E><L><L><T><K><V><W><V><Q><G><H><Y><L><E><Y><R><E><V><P><H><S><S><P><P><Y><Y><E><F><L><W><G><P><R><A><H><S><E><S><I><K><K><K><V><L><E><F><L><A><K><L><N><N><T><V><P><S><S><F><P><S><W><Y><K><D><A><L><K><D><V><E><E><R><V><Q><A><T><I><D><T><A><D><D><A><T><V><M><A><S><E><S><L><S><V><M><S><S><N><V><S><F><S><E>
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.<BOP>
Q9UBF1
Q9NRX6
KISHB_HUMAN
Transmembrane protein 167B
Homo
<M><T><N><V><Y><S><L><D><G><I><L><V><F><G><L><L><F><V><C><T><C><A><Y><F><K><K><V><P><R><L><K><T><W><L><L><S><E><K><K><G><V><W><G><V><F><Y><K><A><A><V><I><G><T><R><L><H><A><A><V><A><I><A><C><V><V><M><A><F><Y><V><L><F><I><K>
Involved in the early part of the secretory pathway.<BOP>
Q9NRX6
P0CG37
CFC1_HUMAN
Cryptic family protein 1
Homo
<M><T><W><R><H><H><V><R><L><L><F><T><V><S><L><A><L><Q><I><I><N><L><G><N><S><Y><Q><R><E><K><H><N><G><G><R><E><E><V><T><K><V><A><T><Q><K><H><R><Q><S><P><L><N><W><T><S><S><H><F><G><E><V><T><G><S><A><E><G><W><G><P><E><E><P><L><P><Y><S><R><A><F><G><E><G><A><S><A><R><P><R><C><C><R><N><G><G><T><C><V><L><G><S><F><C><V><C><P><A><H><F><T><G><R><Y><C><E><H><D><Q><R><R><S><E><C><G><A><L><E><H><G><A><W><T><L><R><A><C><H><L><C><R><C><I><F><G><A><L><H><C><L><P><L><Q><T><P><D><R><C><D><P><K><D><F><L><A><S><H><A><H><G><P><S><A><G><G><A><P><S><L><L><L><L><L><P><C><A><L><L><H><R><L><L><R><P><D><A><P><A><H><P><R><S><L><V><P><S><V><L><Q><R><E><R><R><P><C><G><R><P><G><L><G><H><R><L>
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.<BOP>
P0CG37
Q15329
E2F5_HUMAN
Transcription factor E2F5
Homo
<M><A><A><A><E><P><A><S><S><G><Q><Q><A><P><A><G><Q><G><Q><G><Q><R><P><P><P><Q><P><P><Q><A><Q><A><P><Q><P><P><P><P><P><Q><L><G><G><A><G><G><G><S><S><R><H><E><K><S><L><G><L><L><T><T><K><F><V><S><L><L><Q><E><A><K><D><G><V><L><D><L><K><A><A><A><D><T><L><A><V><R><Q><K><R><R><I><Y><D><I><T><N><V><L><E><G><I><D><L><I><E><K><K><S><K><N><S><I><Q><W><K><G><V><G><A><G><C><N><T><K><E><V><I><D><R><L><R><Y><L><K><A><E><I><E><D><L><E><L><K><E><R><E><L><D><Q><Q><K><L><W><L><Q><Q><S><I><K><N><V><M><D><D><S><I><N><N><R><F><S><Y><V><T><H><E><D><I><C><N><C><F><N><G><D><T><L><L><A><I><Q><A><P><S><G><T><Q><L><E><V><P><I><P><E><M><G><Q><N><G><Q><K><K><Y><Q><I><N><L><K><S><H><S><G><P><I><H><V><L><L><I><N><K><E><S><S><S><S><K><P><V><V><F><P><V><P><P><P><D><D><L><T><Q><P><S><S><Q><S><L><T><P><V><T><P><Q><K><S><S><M><A><T><Q><N><L><P><E><Q><H><V><S><E><R><S><Q><A><L><Q><Q><T><S><A><T><D><I><S><S><A><G><S><I><S><G><D><I><I><D><E><L><M><S><S><D><V><F><P><L><L><R><L><S><P><T><P><A><D><D><Y><N><F><N><L><D><D><N><E><G><V><C><D><L><F><D><V><Q><I><L><N><Y>
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.<BOP>
Q15329
P12544
GRAA_HUMAN
Hanukkah factor
Homo
<M><R><N><S><Y><R><F><L><A><S><S><L><S><V><V><V><S><L><L><L><I><P><E><D><V><C><E><K><I><I><G><G><N><E><V><T><P><H><S><R><P><Y><M><V><L><L><S><L><D><R><K><T><I><C><A><G><A><L><I><A><K><D><W><V><L><T><A><A><H><C><N><L><N><K><R><S><Q><V><I><L><G><A><H><S><I><T><R><E><E><P><T><K><Q><I><M><L><V><K><K><E><F><P><Y><P><C><Y><D><P><A><T><R><E><G><D><L><K><L><L><Q><L><M><E><K><A><K><I><N><K><Y><V><T><I><L><H><L><P><K><K><G><D><D><V><K><P><G><T><M><C><Q><V><A><G><W><G><R><T><H><N><S><A><S><W><S><D><T><L><R><E><V><N><I><T><I><I><D><R><K><V><C><N><D><R><N><H><Y><N><F><N><P><V><I><G><M><N><M><V><C><A><G><S><L><R><G><G><R><D><S><C><N><G><D><S><G><S><P><L><L><C><E><G><V><F><R><G><V><T><S><F><G><L><E><N><K><C><G><D><P><R><G><P><G><V><Y><I><L><L><S><K><K><H><L><N><W><I><I><M><T><I><K><G><A><V>
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse . It cleaves after Lys or Arg . Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death . Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity . Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA .<BOP>
P12544
A0A087WSZ9
TVA30_HUMAN
T cell receptor alpha variable 30
Homo
<M><E><T><L><L><K><V><L><S><G><T><L><L><W><Q><L><T><W><V><R><S><Q><Q><P><V><Q><S><P><Q><A><V><I><L><R><E><G><E><D><A><V><I><N><C><S><S><S><K><A><L><Y><S><V><H><W><Y><R><Q><K><H><G><E><A><P><V><F><L><M><I><L><L><K><G><G><E><Q><K><G><H><D><K><I><S><A><S><F><N><E><K><K><Q><Q><S><S><L><Y><L><T><A><S><Q><L><S><Y><S><G><T><Y><F><C><G><T><E>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A087WSZ9
Q6UX46
ALKL2_HUMAN
Augmentor alpha
Homo
<M><R><G><P><G><H><P><L><L><L><G><L><L><L><V><L><G><A><A><G><R><G><R><G><G><A><E><P><R><E><P><A><D><G><Q><A><L><L><R><L><V><V><E><L><V><Q><E><L><R><K><H><H><S><A><E><H><K><G><L><Q><L><L><G><R><D><C><A><L><G><R><A><E><A><A><G><L><G><P><S><P><E><Q><R><V><E><I><V><P><R><D><L><R><M><K><D><K><F><L><K><H><L><T><G><P><L><Y><F><S><P><K><C><S><K><H><F><H><R><L><Y><H><N><T><R><D><C><T><I><P><A><Y><Y><K><R><C><A><R><L><L><T><R><L><A><V><S><P><V><C><M><E><D><K><Q>
Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation . Cytokine-binding is sufficient to activate LTK . In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK . Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure .<BOP>
Q6UX46
Q9BRQ5
ORAI3_HUMAN
Transmembrane protein 142C
Homo
<M><K><G><G><E><G><D><A><G><E><Q><A><P><L><N><P><E><G><E><S><P><A><G><S><A><T><Y><R><E><F><V><H><R><G><Y><L><D><L><M><G><A><S><Q><H><S><L><R><A><L><S><W><R><R><L><Y><L><S><R><A><K><L><K><A><S><S><R><T><S><A><L><L><S><G><F><A><M><V><A><M><V><E><V><Q><L><E><S><D><H><E><Y><P><P><G><L><L><V><A><F><S><A><C><T><T><V><L><V><A><V><H><L><F><A><L><M><V><S><T><C><L><L><P><H><I><E><A><V><S><N><I><H><N><L><N><S><V><H><Q><S><P><H><Q><R><L><H><R><Y><V><E><L><A><W><G><F><S><T><A><L><G><T><F><L><F><L><A><E><V><V><L><V><G><W><V><K><F><V><P><I><G><A><P><L><D><T><P><T><P><M><V><P><T><S><R><V><P><G><T><L><A><P><V><A><T><S><L><S><P><A><S><N><L><P><R><S><S><A><S><A><A><P><S><Q><A><E><P><A><C><P><P><R><Q><A><C><G><G><G><G><A><H><G><P><G><W><Q><A><A><M><A><S><T><A><I><M><V><P><V><G><L><V><F><V><A><F><A><L><H><F><Y><R><S><L><V><A><H><K><T><D><R><Y><K><Q><E><L><E><E><L><N><R><L><Q><G><E><L><Q><A><V>
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.<BOP>
Q9BRQ5
Q14849
STAR3_HUMAN
START domain-containing protein 3
Homo
<M><S><K><L><P><R><E><L><T><R><D><L><E><R><S><L><P><A><V><A><S><L><G><S><S><L><S><H><S><Q><S><L><S><S><H><L><L><P><P><P><E><K><R><R><A><I><S><D><V><R><R><T><F><C><L><F><V><T><F><D><L><L><F><I><S><L><L><W><I><I><E><L><N><T><N><T><G><I><R><K><N><L><E><Q><E><I><I><Q><Y><N><F><K><T><S><F><F><D><I><F><V><L><A><F><F><R><F><S><G><L><L><L><G><Y><A><V><L><R><L><R><H><W><W><V><I><A><V><T><T><L><V><S><S><A><F><L><I><V><K><V><I><L><S><E><L><L><S><K><G><A><F><G><Y><L><L><P><I><V><S><F><V><L><A><W><L><E><T><W><F><L><D><F><K><V><L><P><Q><E><A><E><E><E><R><W><Y><L><A><A><Q><V><A><V><A><R><G><P><L><L><F><S><G><A><L><S><E><G><Q><F><Y><S><P><P><E><S><F><A><G><S><D><N><E><S><D><E><E><V><A><G><K><K><S><F><S><A><Q><E><R><E><Y><I><R><Q><G><K><E><A><T><A><V><V><D><Q><I><L><A><Q><E><E><N><W><K><F><E><K><N><N><E><Y><G><D><T><V><Y><T><I><E><V><P><F><H><G><K><T><F><I><L><K><T><F><L><P><C><P><A><E><L><V><Y><Q><E><V><I><L><Q><P><E><R><M><V><L><W><N><K><T><V><T><A><C><Q><I><L><Q><R><V><E><D><N><T><L><I><S><Y><D><V><S><A><G><A><A><G><G><V><V><S><P><R><D><F><V><N><V><R><R><I><E><R><R><R><D><R><Y><L><S><S><G><I><A><T><S><H><S><A><K><P><P><T><H><K><Y><V><R><G><E><N><G><P><G><G><F><I><V><L><K><S><A><S><N><P><R><V><C><T><F><V><W><I><L><N><T><D><L><K><G><R><L><P><R><Y><L><I><H><Q><S><L><A><A><T><M><F><E><F><A><F><H><L><R><Q><R><I><S><E><L><G><A><R><A>
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes . Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB . Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes . May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane . However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes . Does not activate transcriptional cholesterol sensing . Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina .<BOP>
Q14849
Q14103
HNRPD_HUMAN
AU-rich element RNA-binding protein 1
Homo
<M><S><E><E><Q><F><G><G><D><G><A><A><A><A><A><T><A><A><V><G><G><S><A><G><E><Q><E><G><A><M><V><A><A><T><Q><G><A><A><A><A><A><G><S><G><A><G><T><G><G><G><T><A><S><G><G><T><E><G><G><S><A><E><S><E><G><A><K><I><D><A><S><K><N><E><E><D><E><G><H><S><N><S><S><P><R><H><S><E><A><A><T><A><Q><R><E><E><W><K><M><F><I><G><G><L><S><W><D><T><T><K><K><D><L><K><D><Y><F><S><K><F><G><E><V><V><D><C><T><L><K><L><D><P><I><T><G><R><S><R><G><F><G><F><V><L><F><K><E><S><E><S><V><D><K><V><M><D><Q><K><E><H><K><L><N><G><K><V><I><D><P><K><R><A><K><A><M><K><T><K><E><P><V><K><K><I><F><V><G><G><L><S><P><D><T><P><E><E><K><I><R><E><Y><F><G><G><F><G><E><V><E><S><I><E><L><P><M><D><N><K><T><N><K><R><R><G><F><C><F><I><T><F><K><E><E><E><P><V><K><K><I><M><E><K><K><Y><H><N><V><G><L><S><K><C><E><I><K><V><A><M><S><K><E><Q><Y><Q><Q><Q><Q><Q><W><G><S><R><G><G><F><A><G><R><A><R><G><R><G><G><G><P><S><Q><N><W><N><Q><G><Y><S><N><Y><W><N><Q><G><Y><G><N><Y><G><Y><N><S><Q><G><Y><G><G><Y><G><G><Y><D><Y><T><G><Y><N><N><Y><Y><G><Y><G><D><Y><S><N><Q><Q><S><G><Y><G><K><V><S><R><R><G><G><H><Q><N><S><Y><K><P><Y>
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly
Q14103
P0CB38
PAB4L_HUMAN
Polyadenylate-binding protein 4-like
Homo
<M><N><V><A><A><K><Y><R><M><A><S><L><Y><V><G><D><L><H><A><D><V><T><E><D><L><L><F><R><K><F><S><T><V><G><P><V><L><S><I><R><I><C><R><D><Q><V><T><R><R><S><L><G><Y><A><Y><V><N><F><L><Q><L><A><D><A><Q><K><A><L><D><T><M><N><F><D><I><I><K><G><K><S><I><R><L><M><W><S><Q><R><D><A><Y><L><R><R><S><G><I><G><N><V><F><I><K><N><L><D><K><S><I><D><N><K><T><L><Y><E><H><F><S><A><F><G><K><I><L><S><S><K><V><M><S><D><D><Q><G><S><K><G><Y><A><F><V><H><F><Q><N><Q><S><A><A><D><R><A><I><E><E><M><N><G><K><L><L><K><G><C><K><V><F><V><G><R><F><K><N><R><K><D><R><E><A><E><L><R><S><K><A><S><E><F><T><N><V><Y><I><K><N><F><G><G><D><M><D><D><E><R><L><K><D><V><F><S><K><Y><G><K><T><L><S><V><K><V><M><T><D><S><S><G><K><S><K><G><F><G><F><V><S><F><D><S><H><E><A><A><K><K><A><V><E><E><M><N><G><R><D><I><N><G><Q><L><I><F><V><G><R><A><Q><K><K><V><E><R><Q><A><E><L><K><Q><M><F><E><Q><L><K><R><E><R><I><R><G><C><Q><G><V><K><L><Y><I><K><N><L><D><D><T><I><D><D><E><K><L><R><N><E><F><S><S><F><G><S><I><S><R><V><K><V><M><Q><E><E><G><Q><S><K><G><F><G><L><I><C><F><S><S><P><E><D><A><T><K><A><M><T><E><M><N><G><R><I><L><G><S><K><P><L><S><I><A><L><A><Q><R><H>
May bind RNA.<BOP>
P0CB38
Q9NWT1
PK1IP_HUMAN
WD repeat-containing protein 84
Homo
<M><E><L><V><A><G><C><Y><E><Q><V><L><F><G><F><A><V><H><P><E><P><E><A><C><G><D><H><E><Q><W><T><L><V><A><D><F><T><H><H><A><H><T><A><S><L><S><A><V><A><V><N><S><R><F><V><V><T><G><S><K><D><E><T><I><H><I><Y><D><M><K><K><K><I><E><H><G><A><L><V><H><H><S><G><T><I><T><C><L><K><F><Y><G><N><R><H><L><I><S><G><A><E><D><G><L><I><C><I><W><D><A><K><K><W><E><C><L><K><S><I><K><A><H><K><G><Q><V><T><F><L><S><I><H><P><S><G><K><L><A><L><S><V><G><T><D><K><T><L><R><T><W><N><L><V><E><G><R><S><A><F><I><K><N><I><K><Q><N><A><H><I><V><E><W><S><P><R><G><E><Q><Y><V><V><I><I><Q><N><K><I><D><I><Y><Q><L><D><T><A><S><I><S><G><T><I><T><N><E><K><R><I><S><S><V><K><F><L><S><E><S><V><L><A><V><A><G><D><E><E><V><I><R><F><F><D><C><D><S><L><V><C><L><C><E><F><K><A><H><E><N><R><V><K><D><M><F><S><F><E><I><P><E><H><H><V><I><V><S><A><S><S><D><G><F><I><K><M><W><K><L><K><Q><D><K><K><V><P><P><S><L><L><C><E><I><N><T><N><A><R><L><T><C><L><G><V><W><L><D><K><V><A><D><M><K><E><S><L><P><P><A><A><E><P><S><P><V><S><K><E><Q><S><K><I><G><K><K><E><P><G><D><T><V><H><K><E><E><K><R><S><K><P><N><T><K><K><R><G><L><T><G><D><S><K><K><A><T><K><E><S><G><L><I><S><T><K><K><R><K><M><V><E><M><L><E><K><K><R><K><K><K><K><I><K><T><M><Q>
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly .<BOP>
Q9NWT1
Q8NGN4
O10G9_HUMAN
Olfactory receptor 10G10
Homo
<M><S><K><T><S><L><V><T><A><F><I><L><T><G><L><P><H><A><P><G><L><D><A><P><L><F><G><I><F><L><V><V><Y><V><L><T><V><L><G><N><L><L><I><L><L><V><I><R><V><D><S><H><L><H><T><P><M><Y><Y><F><L><T><N><L><S><F><I><D><M><W><F><S><T><V><T><V><P><K><M><L><M><T><L><V><S><P><S><G><R><A><I><S><F><H><S><C><V><A><Q><L><Y><F><F><H><F><L><G><S><T><E><C><F><L><Y><T><V><M><S><Y><D><R><Y><L><A><I><S><Y><P><L><R><Y><T><S><M><M><S><G><S><R><C><A><L><L><A><T><S><T><W><L><S><G><S><L><H><S><A><V><Q><T><I><L><T><F><H><L><P><Y><C><G><P><N><Q><I><Q><H><Y><L><C><D><A><P><P><I><L><K><L><A><C><A><D><T><S><A><N><E><M><V><I><F><V><D><I><G><L><V><A><S><G><C><F><L><L><I><V><L><S><Y><V><S><I><V><C><S><I><L><R><I><H><T><S><E><G><R><H><R><A><F><Q><T><C><A><S><H><C><I><V><V><L><C><F><F><V><P><C><V><F><I><Y><L><R><P><G><S><R><D><V><V><D><G><V><V><A><I><F><Y><T><V><L><T><P><L><L><N><P><V><V><Y><T><L><R><N><K><E><V><K><K><A><V><L><K><L><R><D><K><V><A><H><S><Q><G><E>
Odorant receptor.<BOP>
Q8NGN4
O95800
GPR75_HUMAN
Probable G-protein coupled receptor 75
Homo
<M><N><S><T><G><H><L><Q><D><A><P><N><A><T><S><L><H><V><P><H><S><Q><E><G><N><S><T><S><L><Q><E><G><L><Q><D><L><I><H><T><A><T><L><V><T><C><T><F><L><L><A><V><I><F><C><L><G><S><Y><G><N><F><I><V><F><L><S><F><F><D><P><A><F><R><K><F><R><T><N><F><D><F><M><I><L><N><L><S><F><C><D><L><F><I><C><G><V><T><A><P><M><F><T><F><V><L><F><F><S><S><A><S><S><I><P><D><A><F><C><F><T><F><H><L><T><S><S><G><F><I><I><M><S><L><K><T><V><A><V><I><A><L><H><R><L><R><M><V><L><G><K><Q><P><N><R><T><A><S><F><P><C><T><V><L><L><T><L><L><L><W><A><T><S><F><T><L><A><T><L><A><T><L><K><T><S><K><S><H><L><C><L><P><M><S><S><L><I><A><G><K><G><K><A><I><L><S><L><Y><V><V><D><F><T><F><C><V><A><V><V><S><V><S><Y><I><M><I><A><Q><T><L><R><K><N><A><Q><V><R><K><C><P><P><V><I><T><V><D><A><S><R><P><Q><P><F><M><G><V><P><V><Q><G><G><G><D><P><I><Q><C><A><M><P><A><L><Y><R><N><Q><N><Y><N><K><L><Q><H><V><Q><T><R><G><Y><T><K><S><P><N><Q><L><V><T><P><A><A><S><R><L><Q><L><V><S><A><I><N><L><S><T><A><K><D><S><K><A><V><V><T><C><V><I><I><V><L><S><V><L><V><C><C><L><P><L><G><I><S><L><V><Q><V><V><L><S><S><N><G><S><F><I><L><Y><Q><F><E><L><F><G><F><T><L><I><F><F><K><S><G><L><N><P><F><I><Y><S><R><N><S><A><G><L><R><R><K><V><L><W><C><L><Q><Y><I><G><L><G><F><F><C><C><K><Q><K><T><R><L><R><A><M><G><K><G><N><L><E><V><N><R><N><K><S><S><H><H><E><T><N><S><A><Y><M><L><S><P><K><P><Q><K><K><F><V><D><Q><A><C><G><P><S><H><S><K><E><S><M><V><S><P><K><I><S><A><G><H><Q><H><C><G><Q><S><S><S><T><P><I><N><T><R><I><E><P><Y><Y><S><I><Y><N><S><S><P><S><Q><E><E><S><S><P><C><N><L><Q><P><V><N><S><F><G><F><A><N><S><Y><I><A><M><H><Y><H><T><T><N><D><L><V><Q><E><Y><D><S><T><S><A><K><Q><I><P><V><P><S><V>
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.<BOP>
O95800
Q9ULV5
HSF4_HUMAN
Heat shock transcription factor 4
Homo
<M><Q><E><A><P><A><A><L><P><T><E><P><G><P><S><P><V><P><A><F><L><G><K><L><W><A><L><V><G><D><P><G><T><D><H><L><I><R><W><S><P><S><G><T><S><F><L><V><S><D><Q><S><R><F><A><K><E><V><L><P><Q><Y><F><K><H><S><N><M><A><S><F><V><R><Q><L><N><M><Y><G><F><R><K><V><V><S><I><E><Q><G><G><L><L><R><P><E><R><D><H><V><E><F><Q><H><P><S><F><V><R><G><R><E><Q><L><L><E><R><V><R><R><K><V><P><A><L><R><G><D><D><G><R><W><R><P><E><D><L><G><R><L><L><G><E><V><Q><A><L><R><G><V><Q><E><S><T><E><A><R><L><R><E><L><R><Q><Q><N><E><I><L><W><R><E><V><V><T><L><R><Q><S><H><G><Q><Q><H><R><V><I><G><K><L><I><Q><C><L><F><G><P><L><Q><A><G><P><S><N><A><G><G><K><R><K><L><S><L><M><L><D><E><G><S><S><C><P><T><P><A><K><F><N><T><C><P><L><P><G><A><L><L><Q><D><P><Y><F><I><Q><S><P><L><P><E><T><N><L><G><L><S><P><H><R><A><R><G><P><I><I><S><D><I><P><E><D><S><P><S><P><E><G><T><R><L><S><P><S><S><D><G><R><R><E><K><G><L><A><L><L><K><E><E><P><A><S><P><G><G><D><G><E><A><G><L><A><L><A><P><N><E><C><D><F><C><V><T><A><P><P><P><L><P><V><A><V><V><Q><A><I><L><E><G><K><G><S><F><S><P><E><G><P><R><N><A><Q><Q><P><E><P><G><D><P><R><E><I><P><D><R><G><P><L><G><L><E><S><G><D><R><S><P><E><S><L><L><P><P><M><L><L><Q><P><P><Q><E><S><V><E><P><A><G><P><L><D><V><L><G><P><S><L><Q><G><R><E><W><T><L><M><D><L><D><M><E><L><S><L><M><Q><P><L><V><P><E><R><G><E><P><E><L><A><V><K><G><L><N><S><P><S><P><G><K><D><P><T><L><G><A><P><L><L><L><D><V><Q><A><A><L><G><G><P><A><L><G><L><P><G><A><L><T><I><Y><S><T><P><E><S><R><T><A><S><Y><L><G><P><E><A><S><P><S><P>
Transcriptional activator.<BOP>
Q9ULV5
Q9C0D3
ZY11B_HUMAN
Protein zyg-11 homolog B
Homo
<M><P><E><D><Q><A><G><A><A><M><E><E><A><S><P><Y><S><L><L><D><I><C><L><N><F><L><T><T><H><L><E><K><F><C><S><A><R><Q><D><G><T><L><C><L><Q><E><P><G><V><F><P><Q><E><V><A><D><R><L><L><R><T><M><A><F><H><G><L><L><N><D><G><T><V><G><I><F><R><G><N><Q><M><R><L><K><R><A><C><I><R><K><A><K><I><S><A><V><A><F><R><K><A><F><C><H><H><K><L><V><E><L><D><A><T><G><V><N><A><D><I><T><I><T><D><I><I><S><G><L><G><S><N><K><W><I><Q><Q><N><L><Q><C><L><V><L><N><S><L><T><L><S><L><E><D><P><Y><E><R><C><F><S><R><L><S><G><L><R><A><L><S><I><T><N><V><L><F><Y><N><E><D><L><A><E><V><A><S><L><P><R><L><E><S><L><D><I><S><N><T><S><I><T><D><I><T><A><L><L><A><C><K><D><R><L><K><S><L><T><M><H><H><L><K><C><L><K><M><T><T><T><Q><I><L><D><V><V><R><E><L><K><H><L><N><H><L><D><I><S><D><D><K><Q><F><T><S><D><I><A><L><R><L><L><E><Q><K><D><I><L><P><N><L><V><S><L><D><V><S><G><R><K><H><V><T><D><K><A><V><E><A><F><I><Q><Q><R><P><S><M><Q><F><V><G><L><L><A><T><D><A><G><Y><S><E><F><L><T><G><E><G><H><L><K><V><S><G><E><A><N><E><T><Q><I><A><E><A><L><K><R><Y><S><E><R><A><F><F><V><R><E><A><L><F><H><L><F><S><L><T><H><V><M><E><K><T><K><P><E><I><L><K><L><V><V><T><G><M><R><N><H><P><M><N><L><P><V><Q><L><A><A><S><A><C><V><F><N><L><T><K><Q><D><L><A><A><G><M><P><V><R><L><L><A><D><V><T><H><L><L><L><K><A><M><E><H><F><P><N><H><Q><Q><L><Q><K><N><C><L><L><S><L><C><S><D><R><I><L><Q><D><V><P><F><N><R><F><E><A><A><K><L><V><M><Q><W><L><C><N><H><E><D><Q><N><M><Q><R><M><A><V><A><I><I><S><I><L><A><A><K><L><S><T><E><Q><T><A><Q><L><G><T><E><L><F><I><V><R><Q><L><L><Q><I><V><K><Q><K><T><N><Q><N><S><V><D><T><T><L><K><F><T><L><S><A><L><W><N><L><T><D><E><S><P><T><T><C><R><H><F><I><E><N><Q><G><L><E><L><F><M><R><V><L><E><S><F><P><T><E><S><S><I><Q><Q><K><V><L><G><L><L><N><N><I><A><E><V><Q><E><L><H><S><E><L><M><W><K><D><F><I><D><H><I><S><S><L><L><H><S><V><E><V><E><V><S><Y><F><A><A><G><I><I><A><H><L><I><S><R><G><E><Q><A><W><T><L><S><R><S><Q><R><N><S><L><L><D><D><L><H><S><A><I><L><K><W><P><T><P><E><C><E><M><V><A><Y><R><S><F><N><P><F><F><P><L><L><G><C><F><T><T><P><G><V><Q><L><W><A><V><W><A><M><Q><H><V><C><S><K><N><P><S><R><Y><C><S><M><L><I><E><E><G><G><L><Q><H><L><Y><N><I><K><D><H><E><H><T><D><P><H><V><Q><Q><I><A><V><A><I><L><D><S><L><E><K><H><I><V><R><H><G><R><P><P><P><C><K><K><Q><P><Q><A><R><L><N>
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation . Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation .<BOP>
Q9C0D3
Q8TBC3
SHKB1_HUMAN
SETA-binding protein 1
Homo
<M><A><A><A><A><T><A><A><E><G><V><P><S><R><G><P><P><G><E><V><I><H><L><N><V><G><G><K><R><F><S><T><S><R><Q><T><L><T><W><I><P><D><S><F><F><S><S><L><L><S><G><R><I><S><T><L><K><D><E><T><G><A><I><F><I><D><R><D><P><T><V><F><A><P><I><L><N><F><L><R><T><K><E><L><D><P><R><G><V><H><G><S><S><L><L><H><E><A><Q><F><Y><G><L><T><P><L><V><R><R><L><Q><L><R><E><E><L><D><R><S><S><C><G><N><V><L><F><N><G><Y><L><P><P><P><V><F><P><V><K><R><R><N><R><H><S><L><V><G><P><Q><Q><L><G><G><R><P><A><P><V><R><R><S><N><T><M><P><P><N><L><G><N><A><G><L><L><G><R><M><L><D><E><K><T><P><P><S><P><S><G><Q><P><E><E><P><G><M><V><R><L><V><C><G><H><H><N><W><I><A><V><A><Y><T><Q><F><L><V><C><Y><R><L><K><E><A><S><G><W><Q><L><V><F><S><S><P><R><L><D><W><P><I><E><R><L><A><L><T><A><R><V><H><G><G><A><L><G><E><H><D><K><M><V><A><A><A><T><G><S><E><I><L><L><W><A><L><Q><A><E><G><G><G><S><E><I><G><V><F><H><L><G><V><P><V><E><A><L><F><F><V><G><N><Q><L><I><A><T><S><H><T><G><R><I><G><V><W><N><A><V><T><K><H><W><Q><V><Q><E><V><Q><P><I><T><S><Y><D><A><A><G><S><F><L><L><L><G><C><N><N><G><S><I><Y><Y><V><D><V><Q><K><F><P><L><R><M><K><D><N><D><L><L><V><S><E><L><Y><R><D><P><A><E><D><G><V><T><A><L><S><V><Y><L><T><P><K><T><S><D><S><G><N><W><I><E><I><A><Y><G><T><S><S><G><G><V><R><V><I><V><Q><H><P><E><T><V><G><S><G><P><Q><L><F><Q><T><F><T><V><H><R><S><P><V><T><K><I><M><L><S><E><K><H><L><I><S><V><C><A><D><N><N><H><V><R><T><W><S><V><T><R><F><R><G><M><I><S><T><Q><P><G><S><T><P><L><A><S><F><K><I><L><A><L><E><S><A><D><G><H><G><G><C><S><A><G><N><D><I><G><P><Y><G><E><R><D><D><Q><Q><V><F><I><Q><K><V><V><P><S><A><S><Q><L><F><V><R><L><S><S><T><G><Q><R><V><C><S><V><R><S><V><D><G><S><P><T><T><A><F><T><V><L><E><C><E><G><S><R><R><L><G><S><R><P><R><R><Y><L><L><T><G><Q><A><N><G><S><L><A><M><W><D><L><T><T><A><M><D><G><L><G><Q><A><P><A><G><G><L><T><E><Q><E><L><M><E><Q><L><E><H><C><E><L><A><P><P><A><P><S><A><P><S><W><G><C><L><P><S><P><S><P><R><I><S><L><T><S><L><H><S><A><S><S><N><T><S><L><S><G><H><R><G><S><P><S><P><P><Q><A><E><A><R><R><R><G><G><G><S><F><V><E><R><C><Q><E><L><V><R><S><G><P><D><L><R><R><P><P><T><P><A><P><W><P><S><S><G><L><G><T><P><L><T><P><P><K><M><K><L><N><E><T><S><F>
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.<BOP>
Q8TBC3
Q9UHK6
AMACR_HUMAN
2-methylacyl-CoA racemase
Homo
<M><A><L><Q><G><I><S><V><V><E><L><S><G><L><A><P><G><P><F><C><A><M><V><L><A><D><F><G><A><R><V><V><R><V><D><R><P><G><S><R><Y><D><V><S><R><L><G><R><G><K><R><S><L><V><L><D><L><K><Q><P><R><G><A><A><V><L><R><R><L><C><K><R><S><D><V><L><L><E><P><F><R><R><G><V><M><E><K><L><Q><L><G><P><E><I><L><Q><R><E><N><P><R><L><I><Y><A><R><L><S><G><F><G><Q><S><G><S><F><C><R><L><A><G><H><D><I><N><Y><L><A><L><S><G><V><L><S><K><I><G><R><S><G><E><N><P><Y><A><P><L><N><L><L><A><D><F><A><G><G><G><L><M><C><A><L><G><I><I><M><A><L><F><D><R><T><R><T><G><K><G><Q><V><I><D><A><N><M><V><E><G><T><A><Y><L><S><S><F><L><W><K><T><Q><K><L><S><L><W><E><A><P><R><G><Q><N><M><L><D><G><G><A><P><F><Y><T><T><Y><R><T><A><D><G><E><F><M><A><V><G><A><I><E><P><Q><F><Y><E><L><L><I><K><G><L><G><L><K><S><D><E><L><P><N><Q><M><S><M><D><D><W><P><E><M><K><K><K><F><A><D><V><F><A><E><K><T><K><A><E><W><C><Q><I><F><D><G><T><D><A><C><V><T><P><V><L><T><F><E><E><V><V><H><H><D><H><N><K><E><R><G><S><F><I><T><S><E><E><Q><D><V><S><P><R><P><A><P><L><L><L><N><T><P><A><I><P><S><F><K><R><D><P><F><I><G><E><H><T><E><E><I><L><E><E><F><G><F><S><R><E><E><I><Y><Q><L><N><S><D><K><I><I><E><S><N><K><V><K><A><S><L>
Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters . Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs .<BOP>
Q9UHK6
Q9BQQ7
RTP3_HUMAN
Transmembrane protein 7
Homo
<M><A><G><D><T><E><V><W><K><Q><M><F><Q><E><L><M><R><E><V><K><P><W><H><R><W><T><L><R><P><D><K><G><L><L><P><N><V><L><K><P><G><W><M><Q><Y><Q><Q><W><T><F><A><R><F><Q><C><S><S><C><S><R><N><W><A><S><A><Q><V><L><V><L><F><H><M><N><W><S><E><E><K><S><R><G><Q><V><K><M><R><V><F><T><Q><R><C><K><K><C><P><Q><P><L><F><E><D><P><E><F><T><Q><E><N><I><S><R><I><L><K><N><L><V><F><R><I><L><K><K><C><Y><R><G><R><F><Q><L><I><E><E><V><P><M><I><K><D><I><S><L><E><G><P><H><N><S><D><N><C><E><A><C><L><Q><G><F><C><A><G><P><I><Q><V><T><S><L><P><P><S><Q><T><P><R><V><H><S><I><Y><K><V><E><E><V><V><K><P><W><A><S><G><E><N><V><Y><S><Y><A><C><Q><N><H><I><C><R><N><L><S><I><F><C><C><C><V><I><L><I><V><I><V><V><I><V><V><K><T><A><I>
Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.<BOP>
Q9BQQ7
O00221
IKBE_HUMAN
I-kappa-B-epsilon
Homo
<M><N><Q><R><R><S><E><S><R><P><G><N><H><R><L><Q><A><Y><A><E><P><G><K><G><D><S><G><G><A><G><P><L><S><G><S><A><R><R><G><R><G><G><G><G><A><I><R><V><R><R><P><C><W><S><G><G><A><G><R><G><G><G><P><A><W><A><V><R><L><P><T><V><T><A><G><W><T><W><P><A><L><R><T><L><S><S><L><R><A><G><P><S><E><P><H><S><P><G><R><R><P><P><R><A><G><R><P><L><C><Q><A><D><P><Q><P><G><K><A><A><R><R><S><L><E><P><D><P><A><Q><T><G><P><R><P><A><R><A><A><G><M><S><E><A><R><K><G><P><D><E><A><E><E><S><Q><Y><D><S><G><I><E><S><L><R><S><L><R><S><L><P><E><S><T><S><A><P><A><S><G><P><S><D><G><S><P><Q><P><C><T><H><P><P><G><P><V><K><E><P><Q><E><K><E><D><A><D><G><E><R><A><D><S><T><Y><G><S><S><S><L><T><Y><T><L><S><L><L><G><G><P><E><A><E><D><P><A><P><R><L><P><L><P><H><V><G><A><L><S><P><Q><Q><L><E><A><L><T><Y><I><S><E><D><G><D><T><L><V><H><L><A><V><I><H><E><A><P><A><V><L><L><C><C><L><A><L><L><P><Q><E><V><L><D><I><Q><N><N><L><Y><Q><T><A><L><H><L><A><V><H><L><D><Q><P><G><A><V><R><A><L><V><L><K><G><A><S><R><A><L><Q><D><R><H><G><D><T><A><L><H><V><A><C><Q><R><Q><H><L><A><C><A><R><C><L><L><E><G><R><P><E><P><G><R><G><T><S><H><S><L><D><L><Q><L><Q><N><W><Q><G><L><A><C><L><H><I><A><T><L><Q><K><N><Q><P><L><M><E><L><L><L><R><N><G><A><D><I><D><V><Q><E><G><T><S><G><K><T><A><L><H><L><A><V><E><T><Q><E><R><G><L><V><Q><F><L><L><Q><A><G><A><Q><V><D><A><R><M><L><N><G><C><T><P><L><H><L><A><A><G><R><G><L><M><G><I><S><S><T><L><C><K><A><G><A><D><S><L><L><R><N><V><E><D><E><T><P><Q><D><L><T><E><E><S><L><V><L><L><P><F><D><D><L><K><I><S><G><K><L><L><L><C><T><D>
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.<BOP>
O00221
Q9NY65
TBA8_HUMAN
Dephenylalaninated tubulin alpha-8 chain
Homo
<M><R><E><C><I><S><V><H><V><G><Q><A><G><V><Q><I><G><N><A><C><W><E><L><F><C><L><E><H><G><I><Q><A><D><G><T><F><D><A><Q><A><S><K><I><N><D><D><D><S><F><T><T><F><F><S><E><T><G><N><G><K><H><V><P><R><A><V><M><I><D><L><E><P><T><V><V><D><E><V><R><A><G><T><Y><R><Q><L><F><H><P><E><Q><L><I><T><G><K><E><D><A><A><N><N><Y><A><R><G><H><Y><T><V><G><K><E><S><I><D><L><V><L><D><R><I><R><K><L><T><D><A><C><S><G><L><Q><G><F><L><I><F><H><S><F><G><G><G><T><G><S><G><F><T><S><L><L><M><E><R><L><S><L><D><Y><G><K><K><S><K><L><E><F><A><I><Y><P><A><P><Q><V><S><T><A><V><V><E><P><Y><N><S><I><L><T><T><H><T><T><L><E><H><S><D><C><A><F><M><V><D><N><E><A><I><Y><D><I><C><R><R><N><L><D><I><E><R><P><T><Y><T><N><L><N><R><L><I><S><Q><I><V><S><S><I><T><A><S><L><R><F><D><G><A><L><N><V><D><L><T><E><F><Q><T><N><L><V><P><Y><P><R><I><H><F><P><L><V><T><Y><A><P><I><I><S><A><E><K><A><Y><H><E><Q><L><S><V><A><E><I><T><S><S><C><F><E><P><N><S><Q><M><V><K><C><D><P><R><H><G><K><Y><M><A><C><C><M><L><Y><R><G><D><V><V><P><K><D><V><N><V><A><I><A><A><I><K><T><K><R><T><I><Q><F><V><D><W><C><P><T><G><F><K><V><G><I><N><Y><Q><P><P><T><V><V><P><G><G><D><L><A><K><V><Q><R><A><V><C><M><L><S><N><T><T><A><I><A><E><A><W><A><R><L><D><H><K><F><D><L><M><Y><A><K><R><A><F><V><H><W><Y><V><G><E><G><M><E><E><G><E><F><S><E><A><R><E><D><L><A><A><L><E><K><D><Y><E><E><V><G><T><D><S><F><E><E><E><N><E><G><E><E><F>
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.<BOP>
Q9NY65
Q96KP6
TNIP3_HUMAN
Listeria-induced gene protein
Homo
<M><A><H><F><V><Q><G><T><S><R><M><I><A><A><E><S><S><T><E><H><K><E><C><A><E><P><S><T><R><K><N><L><M><N><S><L><E><Q><K><I><R><C><L><E><K><Q><R><K><E><L><L><E><V><N><Q><Q><W><D><Q><Q><F><R><S><M><K><E><L><Y><E><R><K><V><A><E><L><K><T><K><L><D><A><A><E><R><F><L><S><T><R><E><K><D><P><H><Q><R><Q><R><K><D><D><R><Q><R><E><D><D><R><Q><R><D><L><T><R><D><R><L><Q><R><E><E><K><E><K><E><R><L><N><E><E><L><H><E><L><K><E><E><N><K><L><L><K><G><K><N><T><L><A><N><K><E><K><E><H><Y><E><C><E><I><K><R><L><N><K><A><L><Q><D><A><L><N><I><K><C><S><F><S><E><D><C><L><R><K><S><R><V><E><F><C><H><E><E><M><R><T><E><M><E><V><L><K><Q><Q><V><Q><I><Y><E><E><D><F><K><K><E><R><S><D><R><E><R><L><N><Q><E><K><E><E><L><Q><Q><I><N><E><T><S><Q><S><Q><L><N><R><L><N><S><Q><I><K><A><C><Q><M><E><K><E><K><L><E><K><Q><L><K><Q><M><Y><C><P><P><C><N><C><G><L><V><F><H><L><Q><D><P><W><V><P><T><G><P><G><A><V><Q><K><Q><R><E><H><P><P><D><Y><Q><W><Y><A><L><D><Q><L><P><P><D><V><Q><H><K><A><N><G><L><S><S><V><K><K><V><H><P>
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.<BOP>
Q96KP6
P10912
GHR_HUMAN
Serum-binding protein
Homo
<M><D><L><W><Q><L><L><L><T><L><A><L><A><G><S><S><D><A><F><S><G><S><E><A><T><A><A><I><L><S><R><A><P><W><S><L><Q><S><V><N><P><G><L><K><T><N><S><S><K><E><P><K><F><T><K><C><R><S><P><E><R><E><T><F><S><C><H><W><T><D><E><V><H><H><G><T><K><N><L><G><P><I><Q><L><F><Y><T><R><R><N><T><Q><E><W><T><Q><E><W><K><E><C><P><D><Y><V><S><A><G><E><N><S><C><Y><F><N><S><S><F><T><S><I><W><I><P><Y><C><I><K><L><T><S><N><G><G><T><V><D><E><K><C><F><S><V><D><E><I><V><Q><P><D><P><P><I><A><L><N><W><T><L><L><N><V><S><L><T><G><I><H><A><D><I><Q><V><R><W><E><A><P><R><N><A><D><I><Q><K><G><W><M><V><L><E><Y><E><L><Q><Y><K><E><V><N><E><T><K><W><K><M><M><D><P><I><L><T><T><S><V><P><V><Y><S><L><K><V><D><K><E><Y><E><V><R><V><R><S><K><Q><R><N><S><G><N><Y><G><E><F><S><E><V><L><Y><V><T><L><P><Q><M><S><Q><F><T><C><E><E><D><F><Y><F><P><W><L><L><I><I><I><F><G><I><F><G><L><T><V><M><L><F><V><F><L><F><S><K><Q><Q><R><I><K><M><L><I><L><P><P><V><P><V><P><K><I><K><G><I><D><P><D><L><L><K><E><G><K><L><E><E><V><N><T><I><L><A><I><H><D><S><Y><K><P><E><F><H><S><D><D><S><W><V><E><F><I><E><L><D><I><D><E><P><D><E><K><T><E><E><S><D><T><D><R><L><L><S><S><D><H><E><K><S><H><S><N><L><G><V><K><D><G><D><S><G><R><T><S><C><C><E><P><D><I><L><E><T><D><F><N><A><N><D><I><H><E><G><T><S><E><V><A><Q><P><Q><R><L><K><G><E><A><D><L><L><C><L><D><Q><K><N><Q><N><N><S><P><Y><H><D><A><C><P><A><T><Q><Q><P><S><V><I><Q><A><E><K><N><K><P><Q><P><L><P><T><E><G><A><E><S><T><H><Q><A><A><H><I><Q><L><S><N><P><S><S><L><S><N><I><D><F><Y><A><Q><V><S><D><I><T><P><A><G><S><V><V><L><S><P><G><Q><K><N><K><A><G><M><S><Q><C><D><M><H><P><E><M><V><S><L><C><Q><E><N><F><L><M><D><N><A><Y><F><C><E><A><D><A><K><K><C><I><P><V><A><P><H><I><K><V><E><S><H><I><Q><P><S><L><N><Q><E><D><I><Y><I><T><T><E><S><L><T><T><A><A><G><R><P><G><T><G><E><H><V><P><G><S><E><M><P><V><P><D><Y><T><S><I><H><I><V><Q><S><P><Q><G><L><I><L><N><A><T><A><L><P><L><P><D><K><E><F><L><S><S><C><G><Y><V><S><T><D><Q><L><N><K><I><M><P>
Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.<BOP>
P10912
Q9UGM1
ACHA9_HUMAN
Nicotinic acetylcholine receptor subunit alpha-9
Homo
<M><N><W><S><H><S><C><I><S><F><C><W><I><Y><F><A><A><S><R><L><R><A><A><E><T><A><D><G><K><Y><A><Q><K><L><F><N><D><L><F><E><D><Y><S><N><A><L><R><P><V><E><D><T><D><K><V><L><N><V><T><L><Q><I><T><L><S><Q><I><K><D><M><D><E><R><N><Q><I><L><T><A><Y><L><W><I><R><Q><I><W><H><D><A><Y><L><T><W><D><R><D><Q><Y><D><G><L><D><S><I><R><I><P><S><D><L><V><W><R><P><D><I><V><L><Y><N><K><A><D><D><E><S><S><E><P><V><N><T><N><V><V><L><R><Y><D><G><L><I><T><W><D><A><P><A><I><T><K><S><S><C><V><V><D><V><T><Y><F><P><F><D><N><Q><Q><C><N><L><T><F><G><S><W><T><Y><N><G><N><Q><V><D><I><F><N><A><L><D><S><G><D><L><S><D><F><I><E><D><V><E><W><E><V><H><G><M><P><A><V><K><N><V><I><S><Y><G><C><C><S><E><P><Y><P><D><V><T><F><T><L><L><L><K><R><R><S><S><F><Y><I><V><N><L><L><I><P><C><V><L><I><S><F><L><A><P><L><S><F><Y><L><P><A><A><S><G><E><K><V><S><L><G><V><T><I><L><L><A><M><T><V><F><Q><L><M><V><A><E><I><M><P><A><S><E><N><V><P><L><I><G><K><Y><Y><I><A><T><M><A><L><I><T><A><S><T><A><L><T><I><M><V><M><N><I><H><F><C><G><A><E><A><R><P><V><P><H><W><A><R><V><V><I><L><K><Y><M><S><R><V><L><F><V><Y><D><V><G><E><S><C><L><S><P><H><H><S><R><E><R><D><H><L><T><K><V><Y><S><K><L><P><E><S><N><L><K><A><A><R><N><K><D><L><S><R><K><K><D><M><N><K><R><L><K><N><D><L><G><C><Q><G><K><N><P><Q><E><A><E><S><Y><C><A><Q><Y><K><V><L><T><R><N><I><E><Y><I><A><K><C><L><K><D><H><K><A><T><N><S><K><G><S><E><W><K><K><V><A><K><V><I><D><R><F><F><M><W><I><F><F><I><M><V><F><V><M><T><I><L><I><I><A><R><A><D>
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane . The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane . In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion .<BOP>
Q9UGM1
Q86XR7
TCAM2_HUMAN
Toll/interleukin-1 receptor domain-containing protein
Homo
<M><G><I><G><K><S><K><I><N><S><C><P><L><S><L><S><W><G><K><R><H><S><V><D><T><S><P><G><Y><H><E><S><D><S><K><K><S><E><D><L><S><L><C><N><V><A><E><H><S><N><T><T><E><G><P><T><G><K><Q><E><G><A><Q><S><V><E><E><M><F><E><E><E><A><E><E><E><V><F><L><K><F><V><I><L><H><A><E><D><D><T><D><E><A><L><R><V><Q><N><L><L><Q><D><D><F><G><I><K><P><G><I><I><F><A><E><M><P><C><G><R><Q><H><L><Q><N><L><D><D><A><V><N><G><S><A><W><T><I><L><L><L><T><E><N><F><L><R><D><T><W><C><N><F><Q><F><Y><T><S><L><M><N><S><V><N><R><Q><H><K><Y><N><S><V><I><P><M><R><P><L><N><N><P><L><P><R><E><R><T><P><F><A><L><Q><T><I><N><A><L><E><E><E><S><R><G><F><P><T><Q><V><E><R><I><F><Q><E><S><V><Y><K><T><Q><Q><T><I><W><K><E><T><R><N><M><V><Q><R><Q><F><I><A>
Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.<BOP>
Q86XR7
Q96JQ5
M4A4A_HUMAN
Four-span transmembrane protein 1
Homo
<M><H><Q><T><Y><S><R><H><C><R><P><E><E><S><T><F><S><A><A><M><T><T><M><Q><G><M><E><Q><A><M><P><G><A><G><P><G><V><P><Q><L><G><N><M><A><V><I><H><S><H><L><W><K><G><L><Q><E><K><F><L><K><G><E><P><K><V><L><G><V><V><Q><I><L><T><A><L><M><S><L><S><M><G><I><T><M><M><C><M><A><S><N><T><Y><G><S><N><P><I><S><V><Y><I><G><Y><T><I><W><G><S><V><M><F><I><I><S><G><S><L><S><I><A><A><G><I><R><T><T><K><G><L><V><R><G><S><L><G><M><N><I><T><S><S><V><L><A><A><S><G><I><L><I><N><T><F><S><L><A><F><Y><S><F><H><H><P><Y><C><N><Y><Y><G><N><S><N><N><C><H><G><T><M><S><I><L><M><G><L><D><G><M><V><L><L><L><S><V><L><E><F><C><I><A><V><S><L><S><A><F><G><C><K><V><L><C><C><T><P><G><G><V><V><L><I><L><P><S><H><S><H><M><A><E><T><A><S><P><T><P><L><N><E><V>
May be involved in signal transduction as a component of a multimeric receptor complex.<BOP>
Q96JQ5
Q30KQ5
DB115_HUMAN
Defensin, beta 115
Homo
<M><L><P><D><H><F><S><P><L><S><G><D><I><K><L><S><V><L><A><L><V><V><L><V><V><L><A><Q><T><A><P><D><G><W><I><R><R><C><Y><Y><G><T><G><R><C><R><K><S><C><K><E><I><E><R><K><K><E><K><C><G><E><K><H><I><C><C><V><P><K><E><K><D><K><L><S><H><I><H><D><Q><K><E><T><S><E><L><Y><I>
Has antibacterial activity.<BOP>
Q30KQ5
P27216
ANX13_HUMAN
Intestine-specific annexin
Homo
<M><G><N><R><H><A><K><A><S><S><P><Q><G><F><D><V><D><R><D><A><K><K><L><N><K><A><C><K><G><M><G><T><N><E><A><A><I><I><E><I><L><S><G><R><T><S><D><E><R><Q><Q><I><K><Q><K><Y><K><A><T><Y><G><K><E><L><E><E><V><L><K><S><E><L><S><G><N><F><E><K><T><A><L><A><L><L><D><R><P><S><E><Y><A><A><R><Q><L><Q><K><A><M><K><G><L><G><T><D><E><S><V><L><I><E><V><L><C><T><R><T><N><K><E><I><I><A><I><K><E><A><Y><Q><R><L><F><D><R><S><L><E><S><D><V><K><G><D><T><S><G><N><L><K><K><I><L><V><S><L><L><Q><A><N><R><N><E><G><D><D><V><D><K><D><L><A><G><Q><D><A><K><D><L><Y><D><A><G><E><G><R><W><G><T><D><E><L><A><F><N><E><V><L><A><K><R><S><Y><K><Q><L><R><A><T><F><Q><A><Y><Q><I><L><I><G><K><D><I><E><E><A><I><E><E><E><T><S><G><D><L><Q><K><A><Y><L><T><L><V><R><C><A><Q><D><C><E><D><Y><F><A><E><R><L><Y><K><S><M><K><G><A><G><T><D><E><E><T><L><I><R><I><V><V><T><R><A><E><V><D><L><Q><G><I><K><A><K><F><Q><E><K><Y><Q><K><S><L><S><D><M><V><R><S><D><T><S><G><D><F><R><K><L><L><V><A><L><L><H>
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.<BOP>
P27216
Q9Y215
COLQ_HUMAN
Acetylcholinesterase-associated collagen
Homo
<M><V><V><L><N><P><M><T><L><G><I><Y><L><Q><L><F><F><L><S><I><V><S><Q><P><T><F><I><N><S><V><L><P><I><S><A><A><L><P><S><L><D><Q><K><K><R><G><G><H><K><A><C><C><L><L><T><P><P><P><P><P><L><F><P><P><P><F><F><R><G><G><R><S><P><L><L><S><P><D><M><K><N><L><M><L><E><L><E><T><S><Q><S><P><C><M><Q><G><S><L><G><S><P><G><P><P><G><P><Q><G><P><P><G><L><P><G><K><T><G><P><K><G><E><K><G><E><L><G><R><P><G><R><K><G><R><P><G><P><P><G><V><P><G><M><P><G><P><I><G><W><P><G><P><E><G><P><R><G><E><K><G><D><L><G><M><M><G><L><P><G><S><R><G><P><M><G><S><K><G><Y><P><G><S><R><G><E><K><G><S><R><G><E><K><G><D><L><G><P><K><G><E><K><G><F><P><G><F><P><G><M><L><G><Q><K><G><E><M><G><P><K><G><E><P><G><I><A><G><H><R><G><P><T><G><R><P><G><K><R><G><K><Q><G><Q><K><G><D><S><G><V><M><G><P><P><G><K><P><G><P><S><G><Q><P><G><R><P><G><P><P><G><P><P><P><A><G><Q><L><I><M><G><P><K><G><E><R><G><F><P><G><P><P><G><R><C><L><C><G><P><T><M><N><V><N><N><P><S><Y><G><E><S><V><Y><G><P><S><S><P><R><V><P><V><I><F><V><V><N><N><Q><E><E><L><E><R><L><N><T><Q><N><A><I><A><F><R><R><D><Q><R><S><L><Y><F><K><D><S><L><G><W><L><P><I><Q><L><T><P><F><Y><P><V><D><Y><T><A><D><Q><H><G><T><C><G><D><G><L><L><Q><P><G><E><E><C><D><D><G><N><S><D><V><G><D><D><C><I><R><C><H><R><A><Y><C><G><D><G><H><R><H><E><G><V><E><D><C><D><G><S><D><F><G><Y><L><T><C><E><T><Y><L><P><G><S><Y><G><D><L><Q><C><T><Q><Y><C><Y><I><D><S><T><P><C><R><Y><F><T>
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.<BOP>
Q9Y215
Q6UXH8
CCBE1_HUMAN
Full of fluid protein homolog
Homo
<M><V><P><P><P><P><S><R><G><G><A><A><R><G><Q><L><G><R><S><L><G><P><L><L><L><L><L><A><L><G><H><T><W><T><Y><R><E><E><P><E><D><G><D><R><E><I><C><S><E><S><K><I><A><T><T><K><Y><P><C><L><K><S><S><G><E><L><T><T><C><Y><R><K><K><C><C><K><G><Y><K><F><V><L><G><Q><C><I><P><E><D><Y><D><V><C><A><E><A><P><C><E><Q><Q><C><T><D><N><F><G><R><V><L><C><T><C><Y><P><G><Y><R><Y><D><R><E><R><H><R><K><R><E><K><P><Y><C><L><D><I><D><E><C><A><S><S><N><G><T><L><C><A><H><I><C><I><N><T><L><G><S><Y><R><C><E><C><R><E><G><Y><I><R><E><D><D><G><K><T><C><T><R><G><D><K><Y><P><N><D><T><G><H><E><K><S><E><N><M><V><K><A><G><T><C><C><A><T><C><K><E><F><Y><Q><M><K><Q><T><V><L><Q><L><K><Q><K><I><A><L><L><P><N><N><A><A><D><L><G><K><Y><I><T><G><D><K><V><L><A><S><N><T><Y><L><P><G><P><P><G><L><P><G><G><Q><G><P><P><G><S><P><G><P><K><G><S><P><G><F><P><G><M><P><G><P><P><G><Q><P><G><P><R><G><S><M><G><P><M><G><P><S><P><D><L><S><H><I><K><Q><G><R><R><G><P><V><G><P><P><G><A><P><G><R><D><G><S><K><G><E><R><G><A><P><G><P><R><G><S><P><G><P><P><G><S><F><D><F><L><L><L><M><L><A><D><I><R><N><D><I><T><E><L><Q><E><K><V><F><G><H><R><T><H><S><S><A><E><E><F><P><L><P><Q><E><F><P><S><Y><P><E><A><M><D><L><G><S><G><D><D><H><P><R><R><T><E><T><R><D><L><R><A><P><R><D><F><Y><P>
Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.<BOP>
Q6UXH8
P12271
RLBP1_HUMAN
Cellular retinaldehyde-binding protein
Homo
<M><S><E><G><V><G><T><F><R><M><V><P><E><E><E><Q><E><L><R><A><Q><L><E><Q><L><T><T><K><D><H><G><P><V><F><G><P><C><S><Q><L><P><R><H><T><L><Q><K><A><K><D><E><L><N><E><R><E><E><T><R><E><E><A><V><R><E><L><Q><E><M><V><Q><A><Q><A><A><S><G><E><E><L><A><V><A><V><A><E><R><V><Q><E><K><D><S><G><F><F><L><R><F><I><R><A><R><K><F><N><V><G><R><A><Y><E><L><L><R><G><Y><V><N><F><R><L><Q><Y><P><E><L><F><D><S><L><S><P><E><A><V><R><C><T><I><E><A><G><Y><P><G><V><L><S><S><R><D><K><Y><G><R><V><V><M><L><F><N><I><E><N><W><Q><S><Q><E><I><T><F><D><E><I><L><Q><A><Y><C><F><I><L><E><K><L><L><E><N><E><E><T><Q><I><N><G><F><C><I><I><E><N><F><K><G><F><T><M><Q><Q><A><A><S><L><R><T><S><D><L><R><K><M><V><D><M><L><Q><D><S><F><P><A><R><F><K><A><I><H><F><I><H><Q><P><W><Y><F><T><T><T><Y><N><V><V><K><P><F><L><K><S><K><L><L><E><R><V><F><V><H><G><D><D><L><S><G><F><Y><Q><E><I><D><E><N><I><L><P><S><D><F><G><G><T><L><P><K><Y><D><G><K><A><V><A><E><Q><L><F><G><P><Q><A><Q><A><E><N><T><A><F>
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.<BOP>
P12271
Q9H7X3
ZN696_HUMAN
Zinc finger protein 696
Homo
<M><E><P><G><G><E><P><T><G><A><K><E><S><S><T><L><M><E><S><L><A><A><V><K><A><A><F><L><A><Q><A><P><S><G><S><R><S><A><E><V><Q><A><A><Q><S><T><E><P><A><A><E><A><G><A><P><E><G><E><G><H><R><G><G><P><P><R><A><L><G><S><L><G><L><C><E><N><Q><E><A><R><E><R><P><G><G><S><P><R><G><P><V><T><S><E><K><T><G><G><Q><S><G><L><E><S><D><V><P><P><N><A><G><P><G><A><E><G><G><G><S><W><K><G><R><P><F><P><C><G><A><C><G><R><S><F><K><C><S><S><D><A><A><K><H><R><S><I><H><S><G><E><K><P><Y><E><C><S><D><C><G><K><A><F><I><H><S><S><H><V><V><R><H><Q><R><A><H><S><G><E><R><P><Y><A><C><A><E><C><G><K><A><F><G><Q><S><F><N><L><L><R><H><Q><R><V><H><T><G><E><K><P><Y><A><C><A><D><C><G><K><A><F><G><Q><R><S><D><A><A><K><H><R><R><T><H><T><G><E><R><L><Y><A><C><G><E><C><G><K><R><F><L><H><S><S><N><V><V><R><H><R><R><T><H><H><G><E><N><P><Y><E><C><R><E><C><G><Q><A><F><S><Q><S><S><N><L><L><Q><H><Q><R><V><H><T><G><E><R><P><F><A><C><Q><D><C><G><R><A><F><S><R><S><S><F><L><R><E><H><R><R><I><H><T><G><E><K><P><H><Q><C><G><H><C><G><R><A><F><R><A><L><S><G><F><F><R><H><Q><R><L><H><T><G><E><K><P><F><R><C><T><E><C><G><R><A><F><R><L><S><F><H><L><I><Q><H><R><R><V><H><G><A><E>
May be involved in transcriptional regulation.<BOP>
Q9H7X3
Q9BY49
PECR_HUMAN
pVI-ARL
Homo
<M><A><S><W><A><K><G><R><S><Y><L><A><P><G><L><L><Q><G><Q><V><A><I><V><T><G><G><A><T><G><I><G><K><A><I><V><K><E><L><L><E><L><G><S><N><V><V><I><A><S><R><K><L><E><R><L><K><S><A><A><D><E><L><Q><A><N><L><P><P><T><K><Q><A><R><V><I><P><I><Q><C><N><I><R><N><E><E><E><V><N><N><L><V><K><S><T><L><D><T><F><G><K><I><N><F><L><V><N><N><G><G><G><Q><F><L><S><P><A><E><H><I><S><S><K><G><W><H><A><V><L><E><T><N><L><T><G><T><F><Y><M><C><K><A><V><Y><S><S><W><M><K><E><H><G><G><S><I><V><N><I><I><V><P><T><K><A><G><F><P><L><A><V><H><S><G><A><A><R><A><G><V><Y><N><L><T><K><S><L><A><L><E><W><A><C><S><G><I><R><I><N><C><V><A><P><G><V><I><Y><S><Q><T><A><V><E><N><Y><G><S><W><G><Q><S><F><F><E><G><S><F><Q><K><I><P><A><K><R><I><G><V><P><E><E><V><S><S><V><V><C><F><L><L><S><P><A><A><S><F><I><T><G><Q><S><V><D><V><D><G><G><R><S><L><Y><T><H><S><Y><E><V><P><D><H><D><N><W><P><K><G><A><G><D><L><S><V><V><K><K><M><K><E><T><F><K><E><K><A><K><L>
Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.<BOP>
Q9BY49
A1L188
NDUF8_HUMAN
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8
Homo
<M><S><A><N><G><A><V><W><G><R><V><R><S><R><L><R><A><F><P><E><R><L><A><A><C><G><A><E><A><A><A><Y><G><R><C><V><Q><A><S><T><A><P><G><G><R><L><S><K><D><F><C><A><R><E><F><E><A><L><R><S><C><F><A><A><A><A><K><K><T><L><E><G><G><C>
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) . Required to stabilize NDUFAF5 .<BOP>
A1L188
Q9UJA9
ENPP5_HUMAN
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Homo
<M><T><S><K><F><L><L><V><S><F><I><L><A><A><L><S><L><S><T><T><F><S><L><Q><P><D><Q><Q><K><V><L><L><V><S><F><D><G><F><R><W><D><Y><L><Y><K><V><P><T><P><H><F><H><Y><I><M><K><Y><G><V><H><V><K><Q><V><T><N><V><F><I><T><K><T><Y><P><N><H><Y><T><L><V><T><G><L><F><A><E><N><H><G><I><V><A><N><D><M><F><D><P><I><R><N><K><S><F><S><L><D><H><M><N><I><Y><D><S><K><F><W><E><E><A><T><P><I><W><I><T><N><Q><R><A><G><H><T><S><G><A><A><M><W><P><G><T><D><V><K><I><H><K><R><F><P><T><H><Y><M><P><Y><N><E><S><V><S><F><E><D><R><V><A><K><I><I><E><W><F><T><S><K><E><P><I><N><L><G><L><L><Y><W><E><D><P><D><D><M><G><H><H><L><G><P><D><S><P><L><M><G><P><V><I><S><D><I><D><K><K><L><G><Y><L><I><Q><M><L><K><K><A><K><L><W><N><T><L><N><L><I><I><T><S><D><H><G><M><T><Q><C><S><E><E><R><L><I><E><L><D><Q><Y><L><D><K><D><H><Y><T><L><I><D><Q><S><P><V><A><A><I><L><P><K><E><G><K><F><D><E><V><Y><E><A><L><T><H><A><H><P><N><L><T><V><Y><K><K><E><D><V><P><E><R><W><H><Y><K><Y><N><S><R><I><Q><P><I><I><A><V><A><D><E><G><W><H><I><L><Q><N><K><S><D><D><F><L><L><G><N><H><G><Y><D><N><A><L><A><D><M><H><P><I><F><L><A><H><G><P><A><F><R><K><N><F><S><K><E><A><M><N><S><T><D><L><Y><P><L><L><C><H><L><L><N><I><T><A><M><P><H><N><G><S><F><W><N><V><Q><D><L><L><N><S><A><M><P><R><V><V><P><Y><T><Q><S><T><I><L><L><P><G><S><V><K><P><A><E><Y><D><Q><E><G><S><Y><P><Y><F><I><G><V><S><L><G><S><I><I><V><I><V><F><F><V><I><F><I><K><H><L><I><H><S><Q><I><P><A><L><Q><D><M><H><A><E><I><A><Q><P><L><L><Q><A>
Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication.<BOP>
Q9UJA9
Q96IV6
FXDC2_HUMAN
Fatty acid hydroxylase domain-containing protein 2
Homo
<M><K><G><E><A><G><H><M><L><H><N><E><K><S><K><Q><E><G><H><I><W><G><S><M><R><R><T><A><F><I><L><G><S><G><L><L><S><F><V><A><F><W><N><S><V><T><W><H><L><Q><R><F><W><G><A><S><G><Y><F><W><Q><A><Q><W><E><R><L><L><T><T><F><E><G><K><E><W><I><L><F><F><I><G><A><I><Q><V><P><C><L><F><F><W><S><F><N><G><L><L><L><V><V><D><T><T><G><K><P><N><F><I><S><R><Y><R><I><Q><V><G><K><N><E><P><V><D><P><V><K><L><R><Q><S><I><R><T><V><L><F><N><Q><C><M><I><S><F><P><M><V><V><F><L><Y><P><F><L><K><W><W><R><D><P><C><R><R><E><L><P><T><F><H><W><F><L><L><E><L><A><I><F><T><L><I><E><E><V><L><F><Y><Y><S><H><R><L><L><H><H><P><T><F><Y><K><K><I><H><K><K><H><H><E><W><T><A><P><I><G><V><I><S><L><Y><A><H><P><I><E><H><A><V><S><N><M><L><P><V><I><V><G><P><L><V><M><G><S><H><L><S><S><I><T><M><W><F><S><L><A><L><I><I><T><T><I><S><H><C><G><Y><H><L><P><F><L><P><S><P><E><F><H><D><Y><H><H><L><K><F><N><Q><C><Y><G><V><L><G><V><L><D><H><L><H><G><T><D><T><M><F><K><Q><T><K><A><Y><E><R><H><V><L><L><L><G><F><T><P><L><S><E><S><I><P><D><S><P><K><R><M><E>
Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.<BOP>
Q96IV6
Q86WA6
BPHL_HUMAN
Breast epithelial mucin-associated antigen
Homo
<M><V><A><V><L><G><G><R><G><V><L><R><L><R><L><L><L><S><A><L><K><P><G><I><H><V><P><R><A><G><P><A><A><A><F><G><T><S><V><T><S><A><K><V><A><V><N><G><V><Q><L><H><Y><Q><Q><T><G><E><G><D><H><A><V><L><L><L><P><G><M><L><G><S><G><E><T><D><F><G><P><Q><L><K><N><L><N><K><K><L><F><T><V><V><A><W><D><P><R><G><Y><G><H><S><R><P><P><D><R><D><F><P><A><D><F><F><E><R><D><A><K><D><A><V><D><L><M><K><A><L><K><F><K><K><V><S><L><L><G><W><S><D><G><G><I><T><A><L><I><A><A><A><K><Y><P><S><Y><I><H><K><M><V><I><W><G><A><N><A><Y><V><T><D><E><D><S><M><I><Y><E><G><I><R><D><V><S><K><W><S><E><R><T><R><K><P><L><E><A><L><Y><G><Y><D><Y><F><A><R><T><C><E><K><W><V><D><G><I><R><Q><F><K><H><L><P><D><G><N><I><C><R><H><L><L><P><R><V><Q><C><P><A><L><I><V><H><G><E><K><D><P><L><V><P><R><F><H><A><D><F><I><H><K><H><V><K><G><S><R><L><H><L><M><P><E><G><K><H><N><L><H><L><R><F><A><D><E><F><N><K><L><A><E><D><F><L><Q>
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.<BOP>
Q86WA6
Q9Y4X4
KLF12_HUMAN
Transcriptional repressor AP-2rep
Homo
<M><N><I><H><M><K><R><K><T><I><K><N><I><N><T><F><E><N><R><M><L><M><L><D><G><M><P><A><V><R><V><K><T><E><L><L><E><S><E><Q><G><S><P><N><V><H><N><Y><P><D><M><E><A><V><P><L><L><L><N><N><V><K><G><E><P><P><E><D><S><L><S><V><D><H><F><Q><T><Q><T><E><P><V><D><L><S><I><N><K><A><R><T><S><P><T><A><V><S><S><S><P><V><S><M><T><A><S><A><S><S><P><S><S><T><S><T><S><S><S><S><S><S><R><L><A><S><S><P><T><V><I><T><S><V><S><S><A><S><S><S><S><T><V><L><T><P><G><P><L><V><A><S><A><S><G><V><G><G><Q><Q><F><L><H><I><I><H><P><V><P><P><S><S><P><M><N><L><Q><S><N><K><L><S><H><V><H><R><I><P><V><V><V><Q><S><V><P><V><V><Y><T><A><V><R><S><P><G><N><V><N><N><T><I><V><V><P><L><L><E><D><G><R><G><H><G><K><A><Q><M><D><P><R><G><L><S><P><R><Q><S><K><S><D><S><D><D><D><D><L><P><N><V><T><L><D><S><V><N><E><T><G><S><T><A><L><S><I><A><R><A><V><Q><E><V><H><P><S><P><V><S><R><V><R><G><N><R><M><N><N><Q><K><F><P><C><S><I><S><P><F><S><I><E><S><T><R><R><Q><R><R><S><E><S><P><D><S><R><K><R><R><I><H><R><C><D><F><E><G><C><N><K><V><Y><T><K><S><S><H><L><K><A><H><R><R><T><H><T><G><E><K><P><Y><K><C><T><W><E><G><C><T><W><K><F><A><R><S><D><E><L><T><R><H><Y><R><K><H><T><G><V><K><P><F><K><C><A><D><C><D><R><S><F><S><R><S><D><H><L><A><L><H><R><R><R><H><M><L><V>
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.<BOP>
Q9Y4X4
Q8TED0
UTP15_HUMAN
U3 small nucleolar RNA-associated protein 15 homolog
Homo
<M><A><G><Y><K><P><V><A><I><Q><T><Y><P><I><L><G><E><K><I><T><Q><D><T><L><Y><W><N><N><Y><K><T><P><V><Q><I><K><E><F><G><A><V><S><K><V><D><F><S><P><Q><P><P><Y><N><Y><A><V><T><A><S><S><R><I><H><I><Y><G><R><Y><S><Q><E><P><I><K><T><F><S><R><F><K><D><T><A><Y><C><A><T><F><R><Q><D><G><R><L><L><V><A><G><S><E><D><G><G><V><Q><L><F><D><I><S><G><R><A><P><L><R><Q><F><E><G><H><T><K><A><V><H><T><V><D><F><T><A><D><K><Y><H><V><V><S><G><A><D><D><Y><T><V><K><L><W><D><I><P><N><S><K><E><I><L><T><F><K><E><H><S><D><Y><V><R><C><G><C><A><S><K><L><N><P><D><L><F><I><T><G><S><Y><D><H><T><V><K><M><F><D><A><R><T><S><E><S><V><L><S><V><E><H><G><Q><P><V><E><S><V><L><L><F><P><S><G><G><L><L><V><S><A><G><G><R><Y><V><K><V><W><D><M><L><K><G><G><Q><L><L><V><S><L><K><N><H><H><K><T><V><T><C><L><C><L><S><S><S><G><Q><R><L><L><S><G><S><L><D><R><K><V><K><V><Y><S><T><T><S><Y><K><V><V><H><S><F><D><Y><A><A><S><I><L><S><L><A><L><A><H><E><D><E><T><I><V><V><G><M><T><N><G><I><L><S><V><K><H><R><K><S><E><A><K><K><E><S><L><P><R><R><R><R><P><A><Y><R><T><F><I><K><G><K><N><Y><M><K><Q><R><D><D><I><L><I><N><R><P><A><K><K><H><L><E><L><Y><D><R><D><L><K><H><F><R><I><S><K><A><L><D><R><V><L><D><P><T><C><T><I><K><T><P><E><I><T><V><S><I><I><K><E><L><N><R><R><G><V><L><A><N><A><L><A><G><R><D><E><K><E><I><S><H><V><L><N><F><L><I><R><N><L><S><Q><P><R><F><A><P><V><L><I><N><A><A><E><I><I><I><D><I><Y><L><P><V><I><G><Q><S><P><V><V><D><K><K><F><L><L><L><Q><G><L><V><E><K><E><I><D><Y><Q><R><E><L><L><E><T><L><G><M><M><D><M><L><F><A><T><M><R><R><K><E><G><T><S><V><L><E><H><T><S><D><G><F><P><E><N><K><K><I><E><S>
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.<BOP>
Q8TED0
Q9Y3Y4
PYGO1_HUMAN
Pygopus homolog 1
Homo
<M><P><A><E><N><S><P><A><P><A><Y><K><V><S><S><H><G><G><D><S><G><L><D><G><L><G><G><P><G><V><Q><L><G><S><P><D><K><K><K><R><K><A><N><T><Q><G><P><S><F><P><P><L><S><E><Y><A><P><P><P><N><P><N><S><D><H><L><V><A><A><N><P><F><D><D><N><Y><N><T><I><S><Y><K><P><L><P><S><S><N><P><Y><L><G><P><G><Y><P><G><F><G><G><Y><S><T><F><R><M><P><P><H><V><P><P><R><M><S><S><P><Y><C><G><P><Y><S><L><R><N><Q><P><H><P><F><P><Q><N><P><L><G><M><G><F><N><R><P><H><A><F><N><F><G><P><H><D><N><S><S><F><G><N><P><S><Y><N><N><A><L><S><Q><N><V><N><M><P><N><Q><H><F><R><Q><N><P><A><E><N><F><S><Q><I><P><P><Q><N><A><S><Q><V><S><N><P><D><L><A><S><N><F><V><P><G><N><N><S><N><F><T><S><P><L><E><S><N><H><S><F><I><P><P><P><N><T><F><G><Q><A><K><A><P><P><P><K><Q><D><F><T><Q><G><A><T><K><N><T><N><Q><N><S><S><A><H><P><P><H><L><N><M><D><D><T><V><N><Q><S><N><I><E><L><K><N><V><N><R><N><N><A><V><N><Q><E><N><S><R><S><S><S><T><E><A><T><N><N><N><P><A><N><G><T><Q><N><K><P><R><Q><P><R><G><A><A><D><A><C><T><T><E><K><S><N><K><S><S><L><H><P><N><R><H><G><H><S><S><S><D><P><V><Y><P><C><G><I><C><T><N><E><V><N><D><D><Q><D><A><I><L><C><E><A><S><C><Q><K><W><F><H><R><I><C><T><G><M><T><E><T><A><Y><G><L><L><T><A><E><A><S><A><V><W><G><C><D><T><C><M><A><D><K><D><V><Q><L><M><R><T><R><E><T><F><G><P><S><A><V><G><S><D><A>
Involved in signal transduction through the Wnt pathway.<BOP>
Q9Y3Y4
Q8TBG4
AT2L1_HUMAN
Alanine--glyoxylate aminotransferase 2-like 1
Homo
<M><C><E><L><Y><S><K><R><D><T><L><G><L><R><K><K><H><I><G><P><S><C><K><V><F><F><A><S><D><P><I><K><I><V><R><A><Q><R><Q><Y><M><F><D><E><N><G><E><Q><Y><L><D><C><I><N><N><V><A><H><V><G><H><C><H><P><G><V><V><K><A><A><L><K><Q><M><E><L><L><N><T><N><S><R><F><L><H><D><N><I><V><E><Y><A><K><R><L><S><A><T><L><P><E><K><L><S><V><C><Y><F><T><N><S><G><S><E><A><N><D><L><A><L><R><L><A><R><Q><F><R><G><H><Q><D><V><I><T><L><D><H><A><Y><H><G><H><L><S><S><L><I><E><I><S><P><Y><K><F><Q><K><G><K><D><V><K><K><E><F><V><H><V><A><P><T><P><D><T><Y><R><G><K><Y><R><E><D><H><A><D><S><A><S><A><Y><A><D><E><V><K><K><I><I><E><D><A><H><N><S><G><R><K><I><A><A><F><I><A><E><S><M><Q><S><C><G><G><Q><I><I><P><P><A><G><Y><F><Q><K><V><A><E><Y><V><H><G><A><G><G><V><F><I><A><D><E><V><Q><V><G><F><G><R><V><G><K><H><F><W><S><F><Q><M><Y><G><E><D><F><V><P><D><I><V><T><M><G><K><P><M><G><N><G><H><P><V><A><C><V><V><T><T><K><E><I><A><E><A><F><S><S><S><G><M><E><Y><F><N><T><Y><G><G><N><P><V><S><C><A><V><G><L><A><V><L><D><I><I><E><N><E><D><L><Q><G><N><A><K><R><V><G><N><Y><L><T><E><L><L><K><K><Q><K><A><K><H><T><L><I><G><D><I><R><G><I><G><L><F><I><G><I><D><L><V><K><D><H><L><K><R><T><P><A><T><A><E><A><Q><H><I><I><Y><K><M><K><E><K><R><V><L><L><S><A><D><G><P><H><R><N><V><L><K><I><K><P><P><M><C><F><T><E><E><D><A><K><F><M><V><D><Q><L><D><R><I><L><T><V><L><E><E><A><M><G><T><K><T><E><S><V><T><S><E><N><T><P><C><K><T><K><M><L><K><E><A><H><I><E><L><L><R><D><S><T><T><D><S><K><E><N><P><S><R><K><R><N><G><M><C><T><D><T><H><S><L><L><S><K><R><L><K><T>
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.<BOP>
Q8TBG4
Q5VWT5
FYB2_HUMAN
Activation-dependent, raft-recruited ADAP-like phosphoprotein
Homo
<M><E><G><E><G><V><R><N><F><K><E><L><R><A><K><F><Q><N><L><D><A><P><P><L><P><G><P><I><K><F><P><A><G><V><S><P><K><G><D><I><G><G><T><Q><S><T><Q><I><L><A><N><G><K><P><L><S><S><N><H><K><Q><R><T><P><Y><C><S><S><S><E><S><Q><P><L><Q><P><Q><K><I><K><L><A><Q><K><S><E><I><P><K><C><S><N><S><P><G><P><L><G><K><S><T><V><C><S><A><T><S><S><Q><K><A><S><L><L><L><E><V><T><Q><S><N><V><E><I><I><T><K><E><K><V><M><V><A><N><S><F><R><N><K><L><W><N><W><E><K><V><S><S><Q><K><S><E><M><S><S><A><L><L><L><A><N><Y><G><S><K><A><I><H><L><E><G><Q><K><G><M><G><L><T><P><E><E><P><R><K><K><L><E><T><K><G><A><Q><T><L><P><S><Q><K><H><V><V><A><P><K><I><L><H><N><V><S><E><D><P><S><F><V><I><S><Q><H><I><R><K><S><W><E><N><P><P><P><E><R><S><P><A><S><S><P><C><Q><P><I><Y><E><C><E><L><A><S><Q><A><P><E><K><Q><P><D><V><R><H><H><H><L><P><K><T><K><P><L><P><S><I><D><S><L><G><P><P><P><P><K><P><S><R><P><P><I><V><N><L><Q><A><F><Q><R><Q><P><A><A><V><P><K><T><Q><G><E><V><T><V><E><E><G><S><L><S><P><E><R><L><F><N><A><E><F><E><E><P><H><N><Y><E><A><T><I><S><Y><L><R><H><S><G><N><S><I><N><L><C><T><A><K><E><I><A><D><P><T><Y><E><V><G><I><E><E><L><Q><K><P><G><K><N><F><P><Y><P><E><P><S><A><K><H><E><D><K><K><M><K><E><K><Q><P><C><E><L><K><P><K><N><T><E><K><E><P><Y><S><N><H><V><F><K><V><D><A><C><E><G><T><P><E><K><I><Q><M><T><N><V><H><T><G><R><R><N><M><L><A><G><K><Q><E><A><M><I><D><I><I><Q><T><N><P><C><P><E><G><P><K><L><A><R><H><S><Q><G><H><C><G><H><L><E><V><L><E><S><T><K><E><T><P><D><L><G><V><S><K><T><S><S><I><S><E><E><I><Y><D><D><V><E><Y><S><R><K><E><V><P><K><L><N><Y><S><S><S><L><A><S><S><S><E><E><N><R><E><L><Y><E><D><V><Y><K><T><K><N><N><Y><P><K><I><D><L><D><G><K><E><A><L><K><R><L><Q><Q><F><F><K><K><E><K><D><R><F><K><I><K><K><T><K><S><K><E><N><L><S><A><F><S><I><L><L><P><D><L><E><L><K><S><Q><E><V><I><I><Y><D><D><V><D><L><S><E><K><E><S><K><D><E><D><K><L><K><M><W><K><P><K><F><L><T><P><K><E><K><K><E><K><N><G><A><E><E><S><E><S><F><S><P><R><N><F><F><K><T><K><K><Q><N><L><E><K><N><R><M><K><R><E><E><K><L><F><R><E><R><F><K><Y><D><K><E><I><I><V><I><N><T><A><V><A><C><S><N><N><S><R><N><G><I><F><D><L><P><I><S><P><G><E><E><L><E><V><I><D><T><T><E><Q><N><L><V><I><C><R><N><S><K><G><K><Y><G><Y><V><L><I><E><H><L><D><F><K><H><Q><S><W><S><P>
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation .<BOP>
Q5VWT5
O75388
GPR32_HUMAN
Probable G-protein coupled receptor 32
Homo
<M><N><G><V><S><E><G><T><R><G><C><S><D><R><Q><P><G><V><L><T><R><D><R><S><C><S><R><K><M><N><S><S><G><C><L><S><E><E><V><G><S><L><R><P><L><T><V><V><I><L><S><A><S><I><V><V><G><V><L><G><N><G><L><V><L><W><M><T><V><F><R><M><A><R><T><V><S><T><V><C><F><F><H><L><A><L><A><D><F><M><L><S><L><S><L><P><I><A><M><Y><Y><I><V><S><R><Q><W><L><L><G><E><W><A><C><K><L><Y><I><T><F><V><F><L><S><Y><F><A><S><N><C><L><L><V><F><I><S><V><D><R><C><I><S><V><L><Y><P><V><W><A><L><N><H><R><T><V><Q><R><A><S><W><L><A><F><G><V><W><L><L><A><A><A><L><C><S><A><H><L><K><F><R><T><T><R><K><W><N><G><C><T><H><C><Y><L><A><F><N><S><D><N><E><T><A><Q><I><W><I><E><G><V><V><E><G><H><I><I><G><T><I><G><H><F><L><L><G><F><L><G><P><L><A><I><I><G><T><C><A><H><L><I><R><A><K><L><L><R><E><G><W><V><H><A><N><R><P><K><R><L><L><L><V><L><V><S><A><F><F><I><F><W><S><P><F><N><V><V><L><L><V><H><L><W><R><R><V><M><L><K><E><I><Y><H><P><R><M><L><L><I><L><Q><A><S><F><A><L><G><C><V><N><S><S><L><N><P><F><L><Y><V><F><V><G><R><D><F><Q><E><K><F><F><Q><S><L><T><S><A><L><A><R><A><F><G><E><E><E><F><L><S><S><C><P><R><G><N><A><P><R><E>
Orphan receptor.<BOP>
O75388
P12429
ANXA3_HUMAN
Placental anticoagulant protein III
Homo
<M><A><S><I><W><V><G><H><R><G><T><V><R><D><Y><P><D><F><S><P><S><V><D><A><E><A><I><Q><K><A><I><R><G><I><G><T><D><E><K><M><L><I><S><I><L><T><E><R><S><N><A><Q><R><Q><L><I><V><K><E><Y><Q><A><A><Y><G><K><E><L><K><D><D><L><K><G><D><L><S><G><H><F><E><H><L><M><V><A><L><V><T><P><P><A><V><F><D><A><K><Q><L><K><K><S><M><K><G><A><G><T><N><E><D><A><L><I><E><I><L><T><T><R><T><S><R><Q><M><K><D><I><S><Q><A><Y><Y><T><V><Y><K><K><S><L><G><D><D><I><S><S><E><T><S><G><D><F><R><K><A><L><L><T><L><A><D><G><R><R><D><E><S><L><K><V><D><E><H><L><A><K><Q><D><A><Q><I><L><Y><K><A><G><E><N><R><W><G><T><D><E><D><K><F><T><E><I><L><C><L><R><S><F><P><Q><L><K><L><T><F><D><E><Y><R><N><I><S><Q><K><D><I><V><D><S><I><K><G><E><L><S><G><H><F><E><D><L><L><L><A><I><V><N><C><V><R><N><T><P><A><F><L><A><E><R><L><H><R><A><L><K><G><I><G><T><D><E><F><T><L><N><R><I><M><V><S><R><S><E><I><D><L><L><D><I><R><T><E><F><K><K><H><Y><G><Y><S><L><Y><S><A><I><K><S><D><T><S><G><D><Y><E><I><T><L><L><K><I><C><G><G><D><D>
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.<BOP>
P12429
P35659
DEK_HUMAN
Protein DEK
Homo
<M><S><A><S><A><P><A><A><E><G><E><G><T><P><T><Q><P><A><S><E><K><E><P><E><M><P><G><P><R><E><E><S><E><E><E><E><D><E><D><D><E><E><E><E><E><E><E><K><E><K><S><L><I><V><E><G><K><R><E><K><K><K><V><E><R><L><T><M><Q><V><S><S><L><Q><R><E><P><F><T><I><A><Q><G><K><G><Q><K><L><C><E><I><E><R><I><H><F><F><L><S><K><K><K><T><D><E><L><R><N><L><H><K><L><L><Y><N><R><P><G><T><V><S><S><L><K><K><N><V><G><Q><F><S><G><F><P><F><E><K><G><S><V><Q><Y><K><K><K><E><E><M><L><K><K><F><R><N><A><M><L><K><S><I><C><E><V><L><D><L><E><R><S><G><V><N><S><E><L><V><K><R><I><L><N><F><L><M><H><P><K><P><S><G><K><P><L><P><K><S><K><K><T><C><S><K><G><S><K><K><E><R><N><S><S><G><M><A><R><K><A><K><R><T><K><C><P><E><I><L><S><D><E><S><S><S><D><E><D><E><K><K><N><K><E><E><S><S><D><D><E><D><K><E><S><E><E><E><P><P><K><K><T><A><K><R><E><K><P><K><Q><K><A><T><S><K><S><K><K><S><V><K><S><A><N><V><K><K><A><D><S><S><T><T><K><K><N><Q><N><S><S><K><K><E><S><E><S><E><D><S><S><D><D><E><P><L><I><K><K><L><K><K><P><P><T><D><E><E><L><K><E><T><I><K><K><L><L><A><S><A><N><L><E><E><V><T><M><K><Q><I><C><K><K><V><Y><E><N><Y><P><T><Y><D><L><T><E><R><K><D><F><I><K><T><T><V><K><E><L><I><S>
Involved in chromatin organization.<BOP>
P35659
Q49A17
GLTL6_HUMAN
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17
Homo
<M><K><R><K><Q><K><R><F><L><Q><M><T><L><L><F><T><V><A><L><I><F><L><P><N><V><G><L><W><S><L><Y><K><D><K><H><L><V><K><S><A><E><P><G><E><Q><Q><T><F><P><L><G><L><G><D><G><Q><F><Y><S><W><T><D><G><L><R><R><K><D><W><H><D><Y><E><S><I><Q><K><E><A><M><R><S><G><K><G><E><H><G><K><P><Y><P><L><T><E><E><D><H><D><D><S><A><Y><R><E><N><G><F><N><I><F><V><S><N><N><I><A><L><E><R><S><L><P><D><I><R><H><A><N><C><K><H><K><M><Y><L><E><R><L><P><N><T><S><I><I><I><P><F><H><N><E><G><W><T><S><L><L><R><T><I><H><S><I><I><N><R><T><P><G><S><L><I><A><E><I><I><L><V><D><D><F><S><E><R><E><H><L><K><D><K><L><E><E><Y><M><A><R><F><S><K><V><R><I><V><R><T><K><K><R><E><G><L><I><R><T><R><L><L><G><A><S><M><A><R><G><E><V><L><T><F><L><D><S><H><C><E><V><N><V><N><W><L><P><P><L><L><N><Q><I><A><L><N><H><K><T><I><V><C><P><M><I><D><V><I><D><H><N><H><F><G><Y><E><A><Q><A><G><D><A><M><R><G><A><F><D><W><E><M><Y><Y><K><R><I><P><I><P><P><E><L><Q><R><A><D><P><S><D><P><F><E><S><P><V><M><A><G><G><L><F><A><V><D><R><K><W><F><W><E><L><G><G><Y><D><P><G><L><E><I><W><G><G><E><Q><Y><E><I><S><F><K><V><W><M><C><G><G><E><M><F><D><V><P><C><S><R><V><G><H><I><Y><R><K><Y><V><P><Y><K><V><P><S><G><T><S><L><A><R><N><L><K><R><V><A><E><T><W><M><D><E><F><A><E><Y><I><Y><Q><R><R><P><E><Y><R><H><L><S><T><G><D><I><S><A><Q><K><E><L><R><K><Q><L><K><C><K><D><F><K><W><F><M><A><A><V><A><W><D><V><P><K><Y><Y><P><P><V><E><P><P><P><A><A><W><G><E><I><R><N><V><A><A><N><L><C><V><D><S><K><H><G><A><T><G><T><E><L><R><L><D><I><C><V><K><D><G><S><E><R><T><W><S><H><E><Q><L><F><T><F><G><W><R><E><D><I><R><P><G><E><P><L><H><T><R><K><F><C><F><D><A><I><S><H><N><S><P><V><T><L><Y><D><C><H><G><M><K><G><N><Q><L><W><G><Y><R><K><D><R><T><L><F><H><P><V><S><N><S><C><M><D><C><N><P><A><E><K><K><I><F><M><A><R><C><D><P><L><S><E><T><Q><Q><W><I><F><E><H><I><N><M><T><V><L><E><K><F><N><H><H><A><N><S>
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.<BOP>
Q49A17
Q9BUV8
RCAF1_HUMAN
Rab5-interacting protein
Homo
<M><S><G><G><R><R><K><E><E><P><P><Q><P><Q><L><A><N><G><A><L><K><V><S><V><W><S><K><V><L><R><S><D><A><A><W><E><D><K><D><E><F><L><D><V><I><Y><W><F><R><Q><I><I><A><V><V><L><G><V><I><W><G><V><L><P><L><R><G><F><L><G><I><A><G><F><C><L><I><N><A><G><V><L><Y><L><Y><F><S><N><Y><L><Q><I><D><E><E><E><Y><G><G><T><W><E><L><T><K><E><G><F><M><T><S><F><A><L><F><M><V><C><V><A><D><S><F><T><T><G><H><L><D><H><L><L><H><C><H><P><L>
Acts as an assembly factor for mitochondrial respiratory complexes.<BOP>
Q9BUV8
P10828
THB_HUMAN
c-erbA-beta
Homo
<M><T><P><N><S><M><T><E><N><G><L><T><A><W><D><K><P><K><H><C><P><D><R><E><H><D><W><K><L><V><G><M><S><E><A><C><L><H><R><K><S><H><S><E><R><R><S><T><L><K><N><E><Q><S><S><P><H><L><I><Q><T><T><W><T><S><S><I><F><H><L><D><H><D><D><V><N><D><Q><S><V><S><S><A><Q><T><F><Q><T><E><E><K><K><C><K><G><Y><I><P><S><Y><L><D><K><D><E><L><C><V><V><C><G><D><K><A><T><G><Y><H><Y><R><C><I><T><C><E><G><C><K><G><F><F><R><R><T><I><Q><K><N><L><H><P><S><Y><S><C><K><Y><E><G><K><C><V><I><D><K><V><T><R><N><Q><C><Q><E><C><R><F><K><K><C><I><Y><V><G><M><A><T><D><L><V><L><D><D><S><K><R><L><A><K><R><K><L><I><E><E><N><R><E><K><R><R><R><E><E><L><Q><K><S><I><G><H><K><P><E><P><T><D><E><E><W><E><L><I><K><T><V><T><E><A><H><V><A><T><N><A><Q><G><S><H><W><K><Q><K><R><K><F><L><P><E><D><I><G><Q><A><P><I><V><N><A><P><E><G><G><K><V><D><L><E><A><F><S><H><F><T><K><I><I><T><P><A><I><T><R><V><V><D><F><A><K><K><L><P><M><F><C><E><L><P><C><E><D><Q><I><I><L><L><K><G><C><C><M><E><I><M><S><L><R><A><A><V><R><Y><D><P><E><S><E><T><L><T><L><N><G><E><M><A><V><T><R><G><Q><L><K><N><G><G><L><G><V><V><S><D><A><I><F><D><L><G><M><S><L><S><S><F><N><L><D><D><T><E><V><A><L><L><Q><A><V><L><L><M><S><S><D><R><P><G><L><A><C><V><E><R><I><E><K><Y><Q><D><S><F><L><L><A><F><E><H><Y><I><N><Y><R><K><H><H><V><T><H><F><W><P><K><L><L><M><K><V><T><D><L><R><M><I><G><A><C><H><A><S><R><F><L><H><M><K><V><E><C><P><T><E><L><F><P><P><L><F><L><E><V><F><E><D>
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.<BOP>
P10828
P62253
UB2G1_HUMAN
Ubiquitin-conjugating enzyme E2 G1, N-terminally processed
Homo
<M><T><E><L><Q><S><A><L><L><L><R><R><Q><L><A><E><L><N><K><N><P><V><E><G><F><S><A><G><L><I><D><D><N><D><L><Y><R><W><E><V><L><I><I><G><P><P><D><T><L><Y><E><G><G><V><F><K><A><H><L><T><F><P><K><D><Y><P><L><R><P><P><K><M><K><F><I><T><E><I><W><H><P><N><V><D><K><N><G><D><V><C><I><S><I><L><H><E><P><G><E><D><K><Y><G><Y><E><K><P><E><E><R><W><L><P><I><H><T><V><E><T><I><M><I><S><V><I><S><M><L><A><D><P><N><G><D><S><P><A><N><V><D><A><A><K><E><W><R><E><D><R><N><G><E><F><K><R><K><V><A><R><C><V><R><K><S><Q><E><T><A><F><E>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.<BOP>
P62253
P59991
KR122_HUMAN
Keratin-associated protein 12.2
Homo
<M><C><H><T><S><C><S><S><G><C><Q><P><A><C><C><A><P><S><P><C><Q><P><A><C><C><V><P><S><S><C><Q><A><S><C><C><V><P><V><G><C><Q><S><S><V><C><V><P><V><S><F><K><P><A><V><C><L><P><V><S><C><Q><S><S><V><C><V><P><M><S><F><K><S><A><V><C><V><P><V><S><C><Q><S><S><V><C><V><P><V><S><C><R><P><I><V><C><A><A><P><S><C><Q><S><S><L><C><V><P><V><S><C><R><P><V><V><Y><A><A><P><S><C><Q><S><S><G><C><C><Q><P><S><C><T><S><V><L><C><R><P><I><S><Y><S><I><S><S><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
P59991
O95600
KLF8_HUMAN
Zinc finger protein 741
Homo
<M><V><D><M><D><K><L><I><N><N><L><E><V><Q><L><N><S><E><G><G><S><M><Q><V><F><K><Q><V><T><A><S><V><R><N><R><D><P><P><E><I><E><Y><R><S><N><M><T><S><P><T><L><L><D><A><N><P><M><E><N><P><A><L><F><N><D><I><K><I><E><P><P><E><E><L><L><A><S><D><F><S><L><P><Q><V><E><P><V><D><L><S><F><H><K><P><K><A><P><L><Q><P><A><S><M><L><Q><A><P><I><R><P><P><K><P><Q><S><S><P><Q><T><L><V><V><S><T><S><T><S><D><M><S><T><S><A><N><I><P><T><V><L><T><P><G><S><V><L><T><S><S><Q><S><T><G><S><Q><Q><I><L><H><V><I><H><T><I><P><S><V><S><L><P><N><K><M><G><G><L><K><T><I><P><V><V><V><Q><S><L><P><M><V><Y><T><T><L><P><A><D><G><G><P><A><A><I><T><V><P><L><I><G><G><D><G><K><N><A><G><S><V><K><V><D><P><T><S><M><S><P><L><E><I><P><S><D><S><E><E><S><T><I><E><S><G><S><S><A><L><Q><S><L><Q><G><L><Q><Q><E><P><A><A><M><A><Q><M><Q><G><E><E><S><L><D><L><K><R><R><R><I><H><Q><C><D><F><A><G><C><S><K><V><Y><T><K><S><S><H><L><K><A><H><R><R><I><H><T><G><E><K><P><Y><K><C><T><W><D><G><C><S><W><K><F><A><R><S><D><E><L><T><R><H><F><R><K><H><T><G><I><K><P><F><R><C><T><D><C><N><R><S><F><S><R><S><D><H><L><S><L><H><R><R><R><H><D><T><M>
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).<BOP>
O95600
Q96G61
NUD11_HUMAN
hAps1
Homo
<M><K><C><K><P><N><Q><T><R><T><Y><D><P><E><G><F><K><K><R><A><A><C><L><C><F><R><S><E><R><E><D><E><V><L><L><V><S><S><S><R><Y><P><D><R><W><I><V><P><G><G><G><M><E><P><E><E><E><P><G><G><A><A><V><R><E><V><Y><E><E><A><G><V><K><G><K><L><G><R><L><L><G><V><F><E><Q><N><Q><D><R><K><H><R><T><Y><V><Y><V><L><T><V><T><E><L><L><E><D><W><E><D><S><V><S><I><G><R><K><R><E><W><F><K><V><E><D><A><I><K><V><L><Q><C><H><K><P><V><H><A><E><Y><L><E><K><L><K><L><G><G><S><P><T><N><G><N><S><M><A><P><S><S><P><D><S><D><P>
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.<BOP>
Q96G61
O15519
CFLAR_HUMAN
CASP8 and FADD-like apoptosis regulator subunit p12
Homo
<M><S><A><E><V><I><H><Q><V><E><E><A><L><D><T><D><E><K><E><M><L><L><F><L><C><R><D><V><A><I><D><V><V><P><P><N><V><R><D><L><L><D><I><L><R><E><R><G><K><L><S><V><G><D><L><A><E><L><L><Y><R><V><R><R><F><D><L><L><K><R><I><L><K><M><D><R><K><A><V><E><T><H><L><L><R><N><P><H><L><V><S><D><Y><R><V><L><M><A><E><I><G><E><D><L><D><K><S><D><V><S><S><L><I><F><L><M><K><D><Y><M><G><R><G><K><I><S><K><E><K><S><F><L><D><L><V><V><E><L><E><K><L><N><L><V><A><P><D><Q><L><D><L><L><E><K><C><L><K><N><I><H><R><I><D><L><K><T><K><I><Q><K><Y><K><Q><S><V><Q><G><A><G><T><S><Y><R><N><V><L><Q><A><A><I><Q><K><S><L><K><D><P><S><N><N><F><R><L><H><N><G><R><S><K><E><Q><R><L><K><E><Q><L><G><A><Q><Q><E><P><V><K><K><S><I><Q><E><S><E><A><F><L><P><Q><S><I><P><E><E><R><Y><K><M><K><S><K><P><L><G><I><C><L><I><I><D><C><I><G><N><E><T><E><L><L><R><D><T><F><T><S><L><G><Y><E><V><Q><K><F><L><H><L><S><M><H><G><I><S><Q><I><L><G><Q><F><A><C><M><P><E><H><R><D><Y><D><S><F><V><C><V><L><V><S><R><G><G><S><Q><S><V><Y><G><V><D><Q><T><H><S><G><L><P><L><H><H><I><R><R><M><F><M><G><D><S><C><P><Y><L><A><G><K><P><K><M><F><F><I><Q><N><Y><V><V><S><E><G><Q><L><E><D><S><S><L><L><E><V><D><G><P><A><M><K><N><V><E><F><K><A><Q><K><R><G><L><C><T><V><H><R><E><A><D><F><F><W><S><L><C><T><A><D><M><S><L><L><E><Q><S><H><S><S><P><S><L><Y><L><Q><C><L><S><Q><K><L><R><Q><E><R><K><R><P><L><L><D><L><H><I><E><L><N><G><Y><M><Y><D><W><N><S><R><V><S><A><K><E><K><Y><Y><V><W><L><Q><H><T><L><R><K><K><L><I><L><S><Y><T>
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.<BOP>
O15519
Q8NBZ0
IN80E_HUMAN
Coiled-coil domain-containing protein 95
Homo
<M><N><G><P><A><D><G><E><V><D><Y><K><K><K><Y><R><N><L><K><R><K><L><K><F><L><I><Y><E><H><E><C><F><Q><E><E><L><R><K><A><Q><R><K><L><L><K><V><S><R><D><K><S><F><L><L><D><R><L><L><Q><Y><E><N><V><D><E><D><S><S><D><S><D><A><T><A><S><S><D><N><S><E><T><E><G><T><P><K><L><S><D><T><P><A><P><K><R><K><R><S><P><P><L><G><G><A><P><S><P><S><S><L><S><L><P><P><S><T><G><F><P><L><Q><A><S><G><V><P><S><P><Y><L><S><S><L><A><S><S><R><Y><P><P><F><P><S><D><Y><L><A><L><Q><L><P><E><P><S><P><L><R><P><K><R><E><K><R><P><R><L><P><R><K><L><K><M><A><V><G><P><P><D><C><P><V><G><G><P><L><T><F><P><G><R><G><S><G><A><G><V><G><T><T><L><T><P><L><P><P><P><K><M><P><P><P><T><I><L><S><T><V><P><R><Q><M><F><S><D><A><G><S><G><D><D><A><L><D><G><D><D><D><L><V><I><D><I><P><E>
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.<BOP>
Q8NBZ0
Q9NSA0
S22AB_HUMAN
Organic anion:dicarboxylate exchanger OAT4
Homo
<M><A><F><S><K><L><L><E><Q><A><G><G><V><G><L><F><Q><T><L><Q><V><L><T><F><I><L><P><C><L><M><I><P><S><Q><M><L><L><E><N><F><S><A><A><I><P><G><H><R><C><W><T><H><M><L><D><N><G><S><A><V><S><T><N><M><T><P><K><A><L><L><T><I><S><I><P><P><G><P><N><Q><G><P><H><Q><C><R><R><F><R><Q><P><Q><W><Q><L><L><D><P><N><A><T><A><T><S><W><S><E><A><D><T><E><P><C><V><D><G><W><V><Y><D><R><S><V><F><T><S><T><I><V><A><K><W><D><L><V><C><S><S><Q><G><L><K><P><L><S><Q><S><I><F><M><S><G><I><L><V><G><S><F><I><W><G><L><L><S><Y><R><F><G><R><K><P><M><L><S><W><C><C><L><Q><L><A><V><A><G><T><S><T><I><F><A><P><T><F><V><I><Y><C><G><L><R><F><V><A><A><F><G><M><A><G><I><F><L><S><S><L><T><L><M><V><E><W><T><T><T><S><R><R><A><V><T><M><T><V><V><G><C><A><F><S><A><G><Q><A><A><L><G><G><L><A><F><A><L><R><D><W><R><T><L><Q><L><A><A><S><V><P><F><F><A><I><S><L><I><S><W><W><L><P><E><S><A><R><W><L><I><I><K><G><K><P><D><Q><A><L><Q><E><L><R><K><V><A><R><I><N><G><H><K><E><A><K><N><L><T><I><E><V><L><M><S><S><V><K><E><E><V><A><S><A><K><E><P><R><S><V><L><D><L><F><C><V><P><V><L><R><W><R><S><C><A><M><L><V><V><N><F><S><L><L><I><S><Y><Y><G><L><V><F><D><L><Q><S><L><G><R><D><I><F><L><L><Q><A><L><F><G><A><V><D><F><L><G><R><A><T><T><A><L><L><L><S><F><L><G><R><R><T><I><Q><A><G><S><Q><A><M><A><G><L><A><I><L><A><N><M><L><V><P><Q><D><L><Q><T><L><R><V><V><F><A><V><L><G><K><G><C><F><G><I><S><L><T><C><L><T><I><Y><K><A><E><L><F><P><T><P><V><R><M><T><A><D><G><I><L><H><T><V><G><R><L><G><A><M><M><G><P><L><I><L><M><S><R><Q><A><L><P><L><L><P><P><L><L><Y><G><V><I><S><I><A><S><S><L><V><V><L><F><F><L><P><E><T><Q><G><L><P><L><P><D><T><I><Q><D><L><E><S><Q><K><S><T><A><A><Q><G><N><R><Q><E><A><V><T><V><E><S><T><S><L>
Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds . May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus . Maybe also be involved in placental urate homeostasis . Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates . Organic anion glutarate acts as conteranion for E1S renal uptake . Possible transport mode may also include DHEA-S/E1S exchange . Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) . Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha
Q9NSA0
P49335
PO3F4_HUMAN
Octamer-binding transcription factor 9
Homo
<M><A><T><A><A><S><N><P><Y><S><I><L><S><S><T><S><L><V><H><A><D><S><A><G><M><Q><Q><G><S><P><F><R><N><P><Q><K><L><L><Q><S><D><Y><L><Q><G><V><P><S><N><G><H><P><L><G><H><H><W><V><T><S><L><S><D><G><G><P><W><S><S><T><L><A><T><S><P><L><D><Q><Q><D><V><K><P><G><R><E><D><L><Q><L><G><A><I><I><H><H><R><S><P><H><V><A><H><H><S><P><H><T><N><H><P><N><A><W><G><A><S><P><A><P><N><P><S><I><T><S><S><G><Q><P><L><N><V><Y><S><Q><P><G><F><T><V><S><G><M><L><E><H><G><G><L><T><P><P><P><A><A><A><S><A><Q><S><L><H><P><V><L><R><E><P><P><D><H><G><E><L><G><S><H><H><C><Q><D><H><S><D><E><E><T><P><T><S><D><E><L><E><Q><F><A><K><Q><F><K><Q><R><R><I><K><L><G><F><T><Q><A><D><V><G><L><A><L><G><T><L><Y><G><N><V><F><S><Q><T><T><I><C><R><F><E><G><L><Q><L><S><F><K><N><M><C><K><L><K><P><L><L><N><K><W><L><E><E><A><D><S><S><T><G><S><P><T><S><I><D><K><I><A><A><Q><G><R><K><R><K><K><R><T><S><I><E><V><S><V><K><G><V><L><E><T><H><F><L><K><C><P><K><P><A><A><Q><E><I><S><S><L><A><D><S><L><Q><L><E><K><E><V><V><R><V><W><F><C><N><R><R><Q><K><E><K><R><M><T><P><P><G><D><Q><Q><P><H><E><V><Y><S><H><T><V><K><T><D><T><S><C><H><D><L>
Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.<BOP>
P49335
P30566
PUR8_HUMAN
Adenylosuccinase
Homo
<M><A><A><G><G><D><H><G><S><P><D><S><Y><R><S><P><L><A><S><R><Y><A><S><P><E><M><C><F><V><F><S><D><R><Y><K><F><R><T><W><R><Q><L><W><L><W><L><A><E><A><E><Q><T><L><G><L><P><I><T><D><E><Q><I><Q><E><M><K><S><N><L><E><N><I><D><F><K><M><A><A><E><E><E><K><R><L><R><H><D><V><M><A><H><V><H><T><F><G><H><C><C><P><K><A><A><G><I><I><H><L><G><A><T><S><C><Y><V><G><D><N><T><D><L><I><I><L><R><N><A><L><D><L><L><L><P><K><L><A><R><V><I><S><R><L><A><D><F><A><K><E><R><A><S><L><P><T><L><G><F><T><H><F><Q><P><A><Q><L><T><T><V><G><K><R><C><C><L><W><I><Q><D><L><C><M><D><L><Q><N><L><K><R><V><R><D><D><L><R><F><R><G><V><K><G><T><T><G><T><Q><A><S><F><L><Q><L><F><E><G><D><D><H><K><V><E><Q><L><D><K><M><V><T><E><K><A><G><F><K><R><A><F><I><I><T><G><Q><T><Y><T><R><K><V><D><I><E><V><L><S><V><L><A><S><L><G><A><S><V><H><K><I><C><T><D><I><R><L><L><A><N><L><K><E><M><E><E><P><F><E><K><Q><Q><I><G><S><S><A><M><P><Y><K><R><N><P><M><R><S><E><R><C><C><S><L><A><R><H><L><M><T><L><V><M><D><P><L><Q><T><A><S><V><Q><W><F><E><R><T><L><D><D><S><A><N><R><R><I><C><L><A><E><A><F><L><T><A><D><T><I><L><N><T><L><Q><N><I><S><E><G><L><V><V><Y><P><K><V><I><E><R><R><I><R><Q><E><L><P><F><M><A><T><E><N><I><I><M><A><M><V><K><A><G><G><S><R><Q><D><C><H><E><K><I><R><V><L><S><Q><Q><A><A><S><V><V><K><Q><E><G><G><D><N><D><L><I><E><R><I><Q><V><D><A><Y><F><S><P><I><H><S><Q><L><D><H><L><L><D><P><S><S><F><T><G><R><A><S><Q><Q><V><Q><R><F><L><E><E><E><V><Y><P><L><L><K><P><Y><E><S><V><M><K><V><K><A><E><L><C><L>
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.<BOP>
P30566
O43868
S28A2_HUMAN
Solute carrier family 28 member 2
Homo
<M><E><K><A><S><G><R><Q><S><I><A><L><S><T><V><E><T><G><T><V><N><P><G><L><E><L><M><E><K><E><V><E><P><E><G><S><K><R><T><D><A><Q><G><H><S><L><G><D><G><L><G><P><S><T><Y><Q><R><R><S><R><W><P><F><S><K><A><R><S><F><C><K><T><H><A><S><L><F><K><K><I><L><L><G><L><L><C><L><A><Y><A><A><Y><L><L><A><A><C><I><L><N><F><Q><R><A><L><A><L><F><V><I><T><C><L><V><I><F><V><L><V><H><S><F><L><K><K><L><L><G><K><K><L><T><R><C><L><K><P><F><E><N><S><R><L><R><L><W><T><K><W><V><F><A><G><V><S><L><V><G><L><I><L><W><L><A><L><D><T><A><Q><R><P><E><Q><L><I><P><F><A><G><I><C><M><F><I><L><I><L><F><A><C><S><K><H><H><S><A><V><S><W><R><T><V><F><S><G><L><G><L><Q><F><V><F><G><I><L><V><I><R><T><D><L><G><Y><T><V><F><Q><W><L><G><E><Q><V><Q><I><F><L><N><Y><T><V><A><G><S><S><F><V><F><G><D><T><L><V><K><D><V><F><A><F><Q><A><L><P><I><I><I><F><F><G><C><V><V><S><I><L><Y><Y><L><G><L><V><Q><W><V><V><Q><K><V><A><W><F><L><Q><I><T><M><G><T><T><A><T><E><T><L><A><V><A><G><N><I><F><V><G><M><T><E><A><P><L><L><I><R><P><Y><L><G><D><M><T><L><S><E><I><H><A><V><M><T><G><G><F><A><T><I><S><G><T><V><L><G><A><F><I><A><F><G><V><D><A><S><S><L><I><S><A><S><V><M><A><A><P><C><A><L><A><S><S><K><L><A><Y><P><E><V><E><E><S><K><F><K><S><E><E><G><V><K><L><P><R><G><K><E><R><N><V><L><E><A><A><S><N><G><A><V><D><A><I><G><L><A><T><N><V><A><A><N><L><I><A><F><L><A><V><L><A><F><I><N><A><A><L><S><W><L><G><E><L><V><D><I><Q><G><L><T><F><Q><V><I><C><S><Y><L><L><R><P><M><V><F><M><M><G><V><E><W><T><D><C><P><M><V><A><E><M><V><G><I><K><F><F><I><N><E><F><V><A><Y><Q><Q><L><S><Q><Y><K><N><K><R><L><S><G><M><E><E><W><I><E><G><E><K><Q><W><I><S><V><R><A><E><I><I><T><T><F><S><L><C><G><F><A><N><L><S><S><I><G><I><T><L><G><G><L><T><S><I><V><P><H><R><K><S><D><L><S><K><V><V><V><R><A><L><F><T><G><A><C><V><S><L><I><S><A><C><M><A><G><I><L><Y><V><P><R><G><A><E><A><D><C><V><S><F><P><N><T><S><F><T><N><R><T><Y><E><T><Y><M><C><C><R><G><L><F><Q><S><T><S><L><N><G><T><N><P><P><S><F><S><G><P><W><E><D><K><E><F><S><A><M><A><L><T><N><C><C><G><F><Y><N><N><T><V><C><A>
Sodium-dependent and purine-selective transporter . Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) . Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues .<BOP>
O43868
Q8N386
LRC25_HUMAN
Monocyte and plasmacytoid-activated protein
Homo
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Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy . Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.<BOP>
Q8N386
Q9H1M4
DB127_HUMAN
Defensin, beta 127
Homo
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Has antibacterial activity.<BOP>
Q9H1M4