accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
A0A075B6I6 | LV150_HUMAN | Probable non-functional immunoglobulin lambda variable 1-50 | Homo | <M><A><W><S><S><L><L><L><T><L><L><A><H><C><T><G><S><W><A><Q><S><V><L><T><Q><P><P><S><V><S><G><A><P><G><Q><R><V><T><I><S><C><T><G><S><S><S><N><I><G><A><G><Y><V><V><H><W><Y><Q><Q><L><P><G><T><A><P><K><L><L><I><Y><G><N><S><N><R><P><S><G><V><P><D><Q><F><S><G><S><K><S><G><T><S><A><S><L><A><I><T><G><L><Q><S><E><D><E><A><D><Y><Y><C><K><A><W><D><N><S><L><N><A> | Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection | A0A075B6I6 |
Q7Z404 | TMC4_HUMAN | Transmembrane channel-like protein 4 | Homo | <M><E><E><N><P><T><L><E><S><E><A><W><G><S><S><R><G><W><L><A><P><R><E><A><R><G><A><P><C><S><S><P><G><P><S><L><S><S><V><L><N><E><L><P><S><A><A><T><L><R><Y><R><D><P><G><V><L><P><W><G><A><L><E><E><E><E><E><D><G><G><R><S><R><K><A><F><T><E><V><T><Q><T><E><L><Q><D><P><H><P><S><R><E><L><P><W><P><M><Q><A><R><R><A><H><R><Q><R><N><A><S><R><D><Q><V><V><Y><G><S><G><T><K><T><D><R><W><A><R><L><L><R><R><S><K><E><K><T><K><E><G><L><R><S><L><Q><P><W><A><W><T><L><K><R><I><G><G><Q><F><G><A><G><T><E><S><Y><F><S><L><L><R><F><L><L><L><L><N><V><L><A><S><V><L><M><A><C><M><T><L><L><P><T><W><L><G><G><A><P><P><G><P><P><G><P><D><I><S><S><P><C><G><S><Y><N><P><H><S><Q><G><L><V><T><F><A><T><Q><L><F><N><L><L><S><G><E><G><Y><L><E><W><S><P><L><F><Y><G><F><Y><P><P><R><P><R><L><A><V><T><Y><L><C><W><A><F><A><V><G><L><I><C><L><L><L><I><L><H><R><S><V><S><G><L><K><Q><T><L><L><A><E><S><E><A><L><T><S><Y><S><H><R><V><F><S><A><W><D><F><G><L><C><G><D><V><H><V><R><L><R><Q><R><I><I><L><Y><E><L><K><V><E><L><E><E><T><V><V><R><R><Q><A><A><V><R><T><L><G><Q><Q><A><R><V><W><L><V><R><V><L><L><N><L><L><V><V><A><L><L><G><A><A><F><Y><G><V><Y><W><A><T><G><C><T><V><E><L><Q><E><M><P><L><V><Q><E><L><P><L><L><K><L><G><V><N><Y><L><P><S><I><F><I><A><G><V><N><F><V><L><P><P><V><F><K><L><I><A><P><L><E><G><Y><T><R><S><R><Q><I><V><F><I><L><L><R><T><V><F><L><R><L><A><S><L><V><V><L><L><F><S><L><W><N><Q><I><T><C><G><G><D><S><E><A><E><D><C><K><T><C><G><Y><N><Y><K><Q><L><P><C><W><E><T><V><L><G><Q><E><M><Y><K><L><L><L><F><D><L><L><T><V><L><A><V><A><L><L><I><Q><F><P><R><K><L><L><C><G><L><C><P><G><A><L><G><R><L><A><G><T><Q><E><F><Q><V><P><D><E><V><L><G><L><I><Y><A><Q><T><V><V><W><V><G><S><F><F><C><P><L><L><P><L><L><N><T><V><K><F><L><L><L><F><Y><L><K><K><L><T><L><F><S><T><C><S><P><A><A><R><T><F><R><A><S><A><A><N><F><F><F><P><L><V><L><L><L><G><L><A><I><S><S><V><P><L><L><Y><S><I><F><L><I><P><P><S><K><L><C><G><P><F><R><G><Q><S><S><I><W><A><Q><I><P><E><S><I><S><S><L><P><E><T><T><Q><N><F><L><F><F><L><G><T><Q><A><F><A><V><P><L><L><L><I><S><S><I><L><M><A><Y><T><V><A><L><A><N><S><Y><G><R><L><I><S><E><L><K><R><Q><R><Q><T><E><A><Q><N><K><V><F><L><A><R><R><A><V><A><L><T><S><T><K><P><A><L> | Probable ion channel.<BOP> | Q7Z404 |
P34903 | GBRA3_HUMAN | GABA(A) receptor subunit alpha-3 | Homo | <M><I><I><T><Q><T><S><H><C><Y><M><T><S><L><G><I><L><F><L><I><N><I><L><P><G><T><T><G><Q><G><E><S><R><R><Q><E><P><G><D><F><V><K><Q><D><I><G><G><L><S><P><K><H><A><P><D><I><P><D><D><S><T><D><N><I><T><I><F><T><R><I><L><D><R><L><L><D><G><Y><D><N><R><L><R><P><G><L><G><D><A><V><T><E><V><K><T><D><I><Y><V><T><S><F><G><P><V><S><D><T><D><M><E><Y><T><I><D><V><F><F><R><Q><T><W><H><D><E><R><L><K><F><D><G><P><M><K><I><L><P><L><N><N><L><L><A><S><K><I><W><T><P><D><T><F><F><H><N><G><K><K><S><V><A><H><N><M><T><T><P><N><K><L><L><R><L><V><D><N><G><T><L><L><Y><T><M><R><L><T><I><H><A><E><C><P><M><H><L><E><D><F><P><M><D><V><H><A><C><P><L><K><F><G><S><Y><A><Y><T><T><A><E><V><V><Y><S><W><T><L><G><K><N><K><S><V><E><V><A><Q><D><G><S><R><L><N><Q><Y><D><L><L><G><H><V><V><G><T><E><I><I><R><S><S><T><G><E><Y><V><V><M><T><T><H><F><H><L><K><R><K><I><G><Y><F><V><I><Q><T><Y><L><P><C><I><M><T><V><I><L><S><Q><V><S><F><W><L><N><R><E><S><V><P><A><R><T><V><F><G><V><T><T><V><L><T><M><T><T><L><S><I><S><A><R><N><S><L><P><K><V><A><Y><A><T><A><M><D><W><F><I><A><V><C><Y><A><F><V><F><S><A><L><I><E><F><A><T><V><N><Y><F><T><K><R><S><W><A><W><E><G><K><K><V><P><E><A><L><E><M><K><K><K><T><P><A><A><P><A><K><K><T><S><T><T><F><N><I><V><G><T><T><Y><P><I><N><L><A><K><D><T><E><F><S><T><I><S><K><G><A><A><P><S><A><S><S><T><P><T><I><I><A><S><P><K><A><T><Y><V><Q><D><S><P><T><E><T><K><T><Y><N><S><V><S><K><V><D><K><I><S><R><I><I><F><P><V><L><F><A><I><F><N><L><V><Y><W><A><T><Y><V><N><R><E><S><A><I><K><G><M><I><R><K><Q> | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.<BOP> | P34903 |
P0CW00 | TSPY8_HUMAN | Testis-specific Y-encoded protein 8 | Homo | <M><R><P><E><G><S><L><T><Y><W><V><P><E><R><L><R><Q><G><F><C><G><V><G><R><A><A><Q><A><L><V><C><A><S><A><K><E><G><T><A><F><R><M><E><A><V><Q><E><G><A><A><G><V><E><S><E><Q><A><A><L><G><E><E><A><V><L><L><L><D><D><I><M><A><E><V><E><V><V><A><E><E><E><G><L><V><E><R><R><E><E><A><Q><R><A><Q><Q><A><V><P><G><P><G><P><M><T><P><E><S><A><L><E><E><L><L><A><V><Q><V><E><L><E><P><V><N><A><Q><A><R><K><A><F><S><R><Q><R><E><K><M><E><R><R><R><K><P><H><L><D><R><R><G><A><V><I><Q><S><V><P><G><F><W><A><N><V><I><A><N><H><P><Q><M><S><A><L><I><T><D><E><D><E><D><M><L><S><Y><M><V><S><L><E><V><E><E><E><K><H><P><V><H><L><C><K><I><M><L><F><F><R><S><N><P><Y><F><Q><N><K><V><I><T><K><E><Y><L><V><N><I><T><E><Y><R><A><S><H><S><T><P><I><E><W><Y><L><D><Y><E><V><E><A><Y><R><R><R><H><H><N><S><S><L><N><F><F><N><W><F><S><D><H><N><F><A><G><S><N><K><I><A><E><I><L><C><K><D><L><W><R><N><P><L><Q><Y><Y><K><R><M><K><P><P><E><E><G><T><E><T><S><G><D><S><Q><L><L><S> | May be involved in sperm differentiation and proliferation.<BOP> | P0CW00 |
Q9ULX9 | MAFF_HUMAN | V-maf musculoaponeurotic fibrosarcoma oncogene homolog F | Homo | <M><S><V><D><P><L><S><S><K><A><L><K><I><K><R><E><L><S><E><N><T><P><H><L><S><D><E><A><L><M><G><L><S><V><R><E><L><N><R><H><L><R><G><L><S><A><E><E><V><T><R><L><K><Q><R><R><R><T><L><K><N><R><G><Y><A><A><S><C><R><V><K><R><V><C><Q><K><E><E><L><Q><K><Q><K><S><E><L><E><R><E><V><D><K><L><A><R><E><N><A><A><M><R><L><E><L><D><A><L><R><G><K><C><E><A><L><Q><G><F><A><R><S><V><A><A><A><R><G><P><A><T><L><V><A><P><A><S><V><I><T><I><V><K><S><T><P><G><S><G><S><G><P><A><H><G><P><D><P><A><H><G><P><A><S><C><S> | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves . However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene . May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition .<BOP> | Q9ULX9 |
P04198 | MYCN_HUMAN | Class E basic helix-loop-helix protein 37 | Homo | <M><P><S><C><S><T><S><T><M><P><G><M><I><C><K><N><P><D><L><E><F><D><S><L><Q><P><C><F><Y><P><D><E><D><D><F><Y><F><G><G><P><D><S><T><P><P><G><E><D><I><W><K><K><F><E><L><L><P><T><P><P><L><S><P><S><R><G><F><A><E><H><S><S><E><P><P><S><W><V><T><E><M><L><L><E><N><E><L><W><G><S><P><A><E><E><D><A><F><G><L><G><G><L><G><G><L><T><P><N><P><V><I><L><Q><D><C><M><W><S><G><F><S><A><R><E><K><L><E><R><A><V><S><E><K><L><Q><H><G><R><G><P><P><T><A><G><S><T><A><Q><S><P><G><A><G><A><A><S><P><A><G><R><G><H><G><G><A><A><G><A><G><R><A><G><A><A><L><P><A><E><L><A><H><P><A><A><E><C><V><D><P><A><V><V><F><P><F><P><V><N><K><R><E><P><A><P><V><P><A><A><P><A><S><A><P><A><A><G><P><A><V><A><S><G><A><G><I><A><A><P><A><G><A><P><G><V><A><P><P><R><P><G><G><R><Q><T><S><G><G><D><H><K><A><L><S><T><S><G><E><D><T><L><S><D><S><D><D><E><D><D><E><E><E><D><E><E><E><E><I><D><V><V><T><V><E><K><R><R><S><S><S><N><T><K><A><V><T><T><F><T><I><T><V><R><P><K><N><A><A><L><G><P><G><R><A><Q><S><S><E><L><I><L><K><R><C><L><P><I><H><Q><Q><H><N><Y><A><A><P><S><P><Y><V><E><S><E><D><A><P><P><Q><K><K><I><K><S><E><A><S><P><R><P><L><K><S><V><I><P><P><K><A><K><S><L><S><P><R><N><S><D><S><E><D><S><E><R><R><R><N><H><N><I><L><E><R><Q><R><R><N><D><L><R><S><S><F><L><T><L><R><D><H><V><P><E><L><V><K><N><E><K><A><A><K><V><V><I><L><K><K><A><T><E><Y><V><H><S><L><Q><A><E><E><H><Q><L><L><L><E><K><E><K><L><Q><A><R><Q><Q><Q><L><L><K><K><I><E><H><A><R><T><C> | Positively regulates the transcription of MYCNOS in neuroblastoma cells.<BOP> | P04198 |
Q14978 | NOLC1_HUMAN | Nucleolar phosphoprotein p130 | Homo | <M><A><D><A><G><I><R><R><V><V><P><S><D><L><Y><P><L><V><L><G><F><L><R><D><N><Q><L><S><E><V><A><N><K><F><A><K><A><T><G><A><T><Q><Q><D><A><N><A><S><S><L><L><D><I><Y><S><F><W><L><K><S><A><K><V><P><E><R><K><L><Q><A><N><G><P><V><A><K><K><A><K><K><K><A><S><S><S><D><S><E><D><S><S><E><E><E><E><E><V><Q><G><P><P><A><K><K><A><A><V><P><A><K><R><V><G><L><P><P><G><K><A><A><A><K><A><S><E><S><S><S><S><E><E><S><S><D><D><D><D><E><E><D><Q><K><K><Q><P><V><Q><K><G><V><K><P><Q><A><K><A><A><K><A><P><P><K><K><A><K><S><S><D><S><D><S><D><S><S><S><E><D><E><P><P><K><N><Q><K><P><K><I><T><P><V><T><V><K><A><Q><T><K><A><P><P><K><P><A><R><A><A><P><K><I><A><N><G><K><A><A><S><S><S><S><S><S><S><S><S><S><S><S><D><D><S><E><E><E><K><A><A><A><T><P><K><K><T><V><P><K><K><Q><V><V><A><K><A><P><V><K><A><A><T><T><P><T><R><K><S><S><S><S><E><D><S><S><S><D><E><E><E><E><Q><K><K><P><M><K><N><K><P><G><P><Y><S><S><V><P><P><P><S><A><P><P><P><K><K><S><L><G><T><Q><P><P><K><K><A><V><E><K><Q><Q><P><V><E><S><S><E><D><S><S><D><E><S><D><S><S><S><E><E><E><K><K><P><P><T><K><A><V><V><S><K><A><T><T><K><P><P><P><A><K><K><A><A><E><S><S><S><D><S><S><D><S><D><S><S><E><D><D><E><A><P><S><K><P><A><G><T><T><K><N><S><S><N><K><P><A><V><T><T><K><S><P><A><V><K><P><A><A><A><P><K><Q><P><V><G><G><G><Q><K><L><L><T><R><K><A><D><S><S><S><S><E><E><E><S><S><S><S><E><E><E><K><T><K><K><M><V><A><T><T><K><P><K><A><T><A><K><A><A><L><S><L><P><A><K><Q><A><P><Q><G><S><R><D><S><S><S><D><S><D><S><S><S><S><E><E><E><E><E><K><T><S><K><S><A><V><K><K><K><P><Q><K><V><A><G><G><A><A><P><S><K><P><A><S><A><K><K><G><K><A><E><S><S><N><S><S><S><S><D><D><S><S><E><E><E><E><E><K><L><K><G><K><G><S><P><R><P><Q><A><P><K><A><N><G><T><S><A><L><T><A><Q><N><G><K><A><A><K><N><S><E><E><E><E><E><E><K><K><K><A><A><V><V><V><S><K><S><G><S><L><K><K><R><K><Q><N><E><A><A><K><E><A><E><T><P><Q><A><K><K><I><K><L><Q><T><P><N><T><F><P><K><R><K><K><G><E><K><R><A><S><S><P><F><R><R><V><R><E><E><E><I><E><V><D><S><R><V><A><D><N><S><F><D><A><K><R><G><A><A><G><D><W><G><E><R><A><N><Q><V><L><K><F><T><K><G><K><S><F><R><H><E><K><T><K><K><K><R><G><S><Y><R><G><G><S><I><S><V><Q><V><N><S><I><K><F><D><S><E> | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification . Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification . Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus . It has intrinsic GTPase and ATPase activities .<BOP> | Q14978 |
O43164 | PJA2_HUMAN | RING-type E3 ubiquitin transferase Praja-2 | Homo | <M><S><Q><Y><T><E><K><E><P><A><A><M><D><Q><E><S><G><K><A><V><W><P><K><P><A><G><G><Y><Q><T><I><T><G><R><R><Y><G><R><R><H><A><Y><V><S><F><K><P><C><M><T><R><H><E><R><S><L><G><R><A><G><D><D><Y><E><V><L><E><L><D><D><V><P><K><E><N><S><S><G><S><S><P><L><D><Q><V><D><S><S><L><P><S><E><P><I><F><E><K><S><E><T><E><I><P><T><C><G><S><A><L><N><Q><T><T><E><S><S><Q><S><F><V><A><V><H><H><S><E><E><G><R><D><T><L><G><S><S><T><N><L><H><N><H><S><E><G><E><Y><I><P><G><A><C><S><A><S><S><V><Q><N><G><I><A><L><V><H><T><D><S><Y><D><P><D><G><K><H><G><E><D><N><D><H><L><Q><L><S><A><E><V><V><E><G><S><R><Y><Q><E><S><L><G><N><T><V><F><E><L><E><N><R><E><A><E><A><Y><T><G><L><S><P><P><V><P><S><F><N><C><E><V><R><D><E><F><E><E><L><D><S><V><P><L><V><K><S><S><A><G><D><T><E><F><V><H><Q><N><S><Q><E><I><Q><R><S><S><Q><D><E><M><V><S><T><K><Q><Q><N><N><T><S><Q><E><R><Q><T><E><H><S><P><E><D><A><A><C><G><P><G><H><I><C><S><E><Q><N><T><N><D><R><E><K><N><H><G><S><S><P><E><Q><V><V><R><P><K><V><R><K><L><I><S><S><S><Q><V><D><Q><E><T><G><F><N><R><H><E><A><K><Q><R><S><V><Q><R><W><R><E><A><L><E><V><E><E><S><G><S><D><D><L><L><I><K><C><E><E><Y><D><G><E><H><D><C><M><F><L><D><P><P><Y><S><R><V><I><T><Q><R><E><T><E><N><N><Q><M><T><S><E><S><G><A><T><A><G><R><Q><E><V><D><N><T><F><W><N><G><C><G><D><Y><Y><Q><L><Y><D><K><D><E><D><S><S><E><C><S><D><G><E><W><S><A><S><L><P><H><R><F><S><G><T><E><K><D><Q><S><S><S><D><E><S><W><E><T><L><P><G><K><D><E><N><E><P><E><L><Q><S><D><S><S><G><P><E><E><E><N><Q><E><L><S><L><Q><E><G><E><Q><T><S><L><E><E><G><E><I><P><W><L><Q><Y><N><E><V><N><E><S><S><S><D><E><G><N><E><P><A><N><E><F><A><Q><P><A><F><M><L><D><G><N><N><N><L><E><D><D><S><S><V><S><E><D><L><D><V><D><W><S><L><F><D><G><F><A><D><G><L><G><V><A><E><A><I><S><Y><V><D><P><Q><F><L><T><Y><M><A><L><E><E><R><L><A><Q><A><M><E><T><A><L><A><H><L><E><S><L><A><V><D><V><E><V><A><N><P><P><A><S><K><E><S><I><D><G><L><P><E><T><L><V><L><E><D><H><T><A><I><G><Q><E><Q><C><C><P><I><C><C><S><E><Y><I><K><D><D><I><A><T><E><L><P><C><H><H><F><F><H><K><P><C><V><S><I><W><L><Q><K><S><G><T><C><P><V><C><R><R><H><F><P><P><A><V><I><E><A><S><A><A><P><S><S><E><P><D><P><D><A><P><P><S><N><D><S><I><A><E><A><P> | Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype .<BOP> | O43164 |
P02654 | APOC1_HUMAN | Truncated apolipoprotein C-I | Homo | <M><R><L><F><L><S><L><P><V><L><V><V><V><L><S><I><V><L><E><G><P><A><P><A><Q><G><T><P><D><V><S><S><A><L><D><K><L><K><E><F><G><N><T><L><E><D><K><A><R><E><L><I><S><R><I><K><Q><S><E><L><S><A><K><M><R><E><W><F><S><E><T><F><Q><K><V><K><E><K><L><K><I><D><S> | Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.<BOP> | P02654 |
Q13257 | MD2L1_HUMAN | Mitotic arrest deficient 2-like protein 1 | Homo | <M><A><L><Q><L><S><R><E><Q><G><I><T><L><R><G><S><A><E><I><V><A><E><F><F><S><F><G><I><N><S><I><L><Y><Q><R><G><I><Y><P><S><E><T><F><T><R><V><Q><K><Y><G><L><T><L><L><V><T><T><D><L><E><L><I><K><Y><L><N><N><V><V><E><Q><L><K><D><W><L><Y><K><C><S><V><Q><K><L><V><V><V><I><S><N><I><E><S><G><E><V><L><E><R><W><Q><F><D><I><E><C><D><K><T><A><K><D><D><S><A><P><R><E><K><S><Q><K><A><I><Q><D><E><I><R><S><V><I><R><Q><I><T><A><T><V><T><F><L><P><L><L><E><V><S><C><S><F><D><L><L><I><Y><T><D><K><D><L><V><V><P><E><K><W><E><E><S><G><P><Q><F><I><T><N><S><E><E><V><R><L><R><S><F><T><T><T><I><H><K><V><N><S><M><V><A><Y><K><I><P><V><N><D> | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate . In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 . Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate .<BOP> | Q13257 |
Q01740 | FMO1_HUMAN | Fetal hepatic flavin-containing monooxygenase 1 | Homo | <M><A><K><R><V><A><I><V><G><A><G><V><S><G><L><A><S><I><K><C><C><L><E><E><G><L><E><P><T><C><F><E><R><S><D><D><L><G><G><L><W><R><F><T><E><H><V><E><E><G><R><A><S><L><Y><K><S><V><V><S><N><S><C><K><E><M><S><C><Y><S><D><F><P><F><P><E><D><Y><P><N><Y><V><P><N><S><Q><F><L><E><Y><L><K><M><Y><A><N><H><F><D><L><L><K><H><I><Q><F><K><T><K><V><C><S><V><T><K><C><S><D><S><A><V><S><G><Q><W><E><V><V><T><M><H><E><E><K><Q><E><S><A><I><F><D><A><V><M><V><C><T><G><F><L><T><N><P><Y><L><P><L><D><S><F><P><G><I><N><A><F><K><G><Q><Y><F><H><S><R><Q><Y><K><H><P><D><I><F><K><D><K><R><V><L><V><I><G><M><G><N><S><G><T><D><I><A><V><E><A><S><H><L><A><E><K><V><F><L><S><T><T><G><G><G><W><V><I><S><R><I><F><D><S><G><Y><P><W><D><M><V><F><M><T><R><F><Q><N><M><L><R><N><S><L><P><T><P><I><V><T><W><L><M><E><R><K><I><N><N><W><L><N><H><A><N><Y><G><L><I><P><E><D><R><T><Q><L><K><E><F><V><L><N><D><E><L><P><G><R><I><I><T><G><K><V><F><I><R><P><S><I><K><E><V><K><E><N><S><V><I><F><N><N><T><S><K><E><E><P><I><D><I><I><V><F><A><T><G><Y><T><F><A><F><P><F><L><D><E><S><V><V><K><V><E><D><G><Q><A><S><L><Y><K><Y><I><F><P><A><H><L><Q><K><P><T><L><A><I><I><G><L><I><K><P><L><G><S><M><I><P><T><G><E><T><Q><A><R><W><A><V><R><V><L><K><G><V><N><K><L><P><P><P><S><V><M><I><E><E><I><N><A><R><K><E><N><K><P><S><W><F><G><L><C><Y><C><K><A><L><Q><S><D><Y><I><T><Y><I><D><E><L><L><T><Y><I><N><A><K><P><N><L><F><S><M><L><L><T><D><P><H><L><A><L><T><V><F><F><G><P><C><S><P><Y><Q><F><R><L><T><G><P><G><K><W><E><G><A><R><N><A><I><M><T><Q><W><D><R><T><F><K><V><I><K><A><R><V><V><Q><E><S><P><S><P><F><E><S><F><L><K><V><F><S><F><L><A><L><L><V><A><I><F><L><I><F><L> | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.<BOP> | Q01740 |
Q8IXW5 | RPAP2_HUMAN | RNA polymerase II-associated protein 2 | Homo | <M><A><D><F><A><G><P><S><S><A><G><R><K><A><G><A><P><R><C><S><R><K><A><A><G><T><K><Q><T><S><T><L><K><Q><E><D><A><S><K><R><K><A><E><L><E><A><A><V><R><K><K><I><E><F><E><R><K><A><L><H><I><V><E><Q><L><L><E><E><N><I><T><E><E><F><L><M><E><C><G><R><F><I><T><P><A><H><Y><S><D><V><V><D><E><R><S><I><V><K><L><C><G><Y><P><L><C><Q><K><K><L><G><I><V><P><K><Q><K><Y><K><I><S><T><K><T><N><K><V><Y><D><I><T><E><R><K><S><F><C><S><N><F><C><Y><Q><A><S><K><F><F><E><A><Q><I><P><K><T><P><V><W><V><R><E><E><E><R><H><P><D><F><Q><L><L><K><E><E><Q><S><G><H><S><G><E><E><V><Q><L><C><S><K><A><I><K><T><S><D><I><D><N><P><S><H><F><E><K><Q><Y><E><S><S><S><S><S><T><H><S><D><S><S><S><D><N><E><Q><D><F><V><S><S><I><L><P><G><N><R><P><N><S><T><N><I><R><P><Q><L><H><Q><K><S><I><M><K><K><K><A><G><H><K><A><N><S><K><H><K><D><K><E><Q><T><V><V><D><V><T><E><Q><L><G><D><C><K><L><D><S><Q><E><K><D><A><T><C><E><L><P><L><Q><K><V><N><T><Q><S><S><S><N><S><T><L><P><E><R><L><K><A><S><E><N><S><E><S><E><Y><S><R><S><E><I><T><L><V><G><I><S><K><K><S><A><E><H><F><K><R><K><F><A><K><S><N><Q><V><S><R><S><V><S><S><S><V><Q><V><C><P><E><V><G><K><R><N><L><L><K><V><L><K><E><T><L><I><E><W><K><T><E><E><T><L><R><F><L><Y><G><Q><N><Y><A><S><V><C><L><K><P><E><A><S><L><V><K><E><E><L><D><E><D><D><I><I><S><D><P><D><S><H><F><P><A><W><R><E><S><Q><N><S><L><D><E><S><L><P><F><R><G><S><G><T><A><I><K><P><L><P><S><Y><E><N><L><K><K><E><T><E><K><L><N><L><R><I><R><E><F><Y><R><G><R><Y><V><L><G><E><E><T><T><K><S><Q><D><S><E><E><H><D><S><T><F><P><L><I><D><S><S><S><Q><N><Q><I><R><K><R><I><V><L><E><K><L><S><K><V><L><P><G><L><L><V><P><L><Q><I><T><L><G><D><I><Y><T><Q><L><K><N><L><V><R><T><F><R><L><T><N><R><N><I><I><H><K><P><A><E><W><T><L><I><A><M><V><L><L><S><L><L><T><P><I><L><G><I><Q><K><H><S><Q><E><G><M><V><F><T><R><F><L><D><T><L><L><E><E><L><H><L><K><N><E><D><L><E><S><L><T><I><I><F><R><T><S><C><L><P><E> | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.<BOP> | Q8IXW5 |
A6NK59 | ASB14_HUMAN | Ankyrin repeat and SOCS box protein 14 | Homo | <M><D><N><Y><T><S><D><E><D><I><D><E><D><F><D><T><Q><L><I><I><Q><Q><S><L><Q><D><I><Y><K><P><G><T><A><Q><H><A><P><K><D><E><S><L><H><S><F><L><S><A><D><Y><K><K><I><V><E><T><I><E><K><V><G><K><E><D><A><L><S><H><L><T><K><Y><H><S><A><F><G><E><A><D><E><I><G><W><I><P><L><H><K><A><A><V><Q><L><N><R><K><I><L><E><I><T><L><S><A><S><D><P><S><L><W><E><Q><T><T><H><N><G><E><T><P><L><F><L><A><V><S><S><C><L><L><E><N><A><T><F><L><L><L><N><G><C><N><P><N><A><K><N><F><E><G><N><S><P><L><L><A><A><V><L><R><D><C><Y><D><M><A><A><L><L><I><N><Y><G><A><D><V><N><L><R><C><A><N><E><R><T><A><L><H><E><A><A><K><L><G><R><E><D><M><V><K><L><M><L><V><S><G><A><H><P><D><P><Q><S><T><Y><G><F><T><P><L><A><L><A><A><Q><S><G><H><T><E><I><M><E><M><L><L><R><K><G><K><I><F><C><L><A><S><D><S><S><S><I><L><L><E><A><A><S><G><G><N><P><D><A><V><A><L><L><L><E><Y><G><A><D><A><N><I><P><K><N><S><G><H><L><P><I><H><V><A><A><D><R><G><H><L><L><A><L><K><I><L><I><P><V><T><D><L><A><A><I><K><Q><S><G><I><S><P><V><H><C><A><A><A><G><A><H><P><Q><C><L><E><L><L><I><Q><A><G><F><D><V><N><F><M><L><D><Q><R><I><N><K><H><Y><D><D><H><R><K><S><A><L><Y><F><A><V><S><N><S><D><L><S><S><V><K><L><L><L><S><A><G><A><L><P><N><Q><D><P><V><N><C><L><Q><I><A><L><R><M><G><N><Y><E><L><I><S><L><L><L><R><H><G><A><N><V><N><Y><F><C><R><V><N><P><L><H><F><P><S><A><L><Q><Y><T><L><K><D><E><V><M><L><R><M><L><L><N><Y><G><Y><D><T><E><R><C><F><D><C><P><H><G><D><K><V><H><P><S><Y><T><V><E><G><W><T><S><T><V><I><K><D><T><K><F><C><E><V><I><T><L><S><W><L><Q><H><L><S><G><K><V><V><R><V><M><L><D><Y><V><D><Q><V><R><I><C><S><K><L><K><A><V><L><Q><K><Q><G><I><W><S><E><I><H><F><I><L><T><N><P><R><S><L><K><H><L><C><R><L><K><I><R><K><C><M><G><R><L><H><L><R><C><P><V><F><M><S><F><L><P><L><P><N><R><L><K><A><Y><V><L><Y><K><E><Y><D><L><Y><G><Q><G><I><F><T><G><T><W> | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.<BOP> | A6NK59 |
Q330K2 | NDUF6_HUMAN | Putative phytoene synthase | Homo | <M><A><A><S><A><H><G><S><V><W><G><P><L><R><L><G><I><P><G><L><C><C><R><R><P><P><L><G><L><Y><A><R><M><R><R><L><P><G><P><E><V><S><G><R><S><V><A><A><A><S><G><P><G><A><W><G><T><D><H><Y><C><L><E><L><L><R><K><R><D><Y><E><G><Y><L><C><S><L><L><L><P><A><E><S><R><S><S><V><F><A><L><R><A><F><N><V><E><L><A><Q><V><K><D><S><V><S><E><K><T><I><G><L><M><R><M><Q><F><W><K><K><T><V><E><D><I><Y><C><D><N><P><P><H><Q><P><V><A><I><E><L><W><K><A><V><K><R><H><N><L><T><K><R><W><L><M><K><I><V><D><E><R><E><K><N><L><D><D><K><A><Y><R><N><I><K><E><L><E><N><Y><A><E><N><T><Q><S><S><L><L><Y><L><T><L><E><I><L><G><I><K><D><L><H><A><D><H><A><A><S><H><I><G><K><A><Q><G><I><V><T><C><L><R><A><T><P><Y><H><G><S><R><R><K><V><F><L><P><M><D><I><C><M><L><H><G><V><S><Q><E><D><F><L><R><R><N><Q><D><K><N><V><R><D><V><I><Y><D><I><A><S><Q><A><H><L><H><L><K><H><A><R><S><F><H><K><T><V><P><V><K><A><F><P><A><F><L><Q><T><V><S><L><E><D><F><L><K><K><I><Q><R><V><D><F><D><I><F><H><P><S><L><Q><Q><K><N><T><L><L><P><L><Y><L><Y><I><Q><S><W><R><K><T><Y> | Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1.<BOP> | Q330K2 |
P98182 | ZN200_HUMAN | Zinc finger protein 200 | Homo | <M><M><A><A><K><V><V><P><M><P><P><K><P><K><Q><S><F><I><L><R><V><P><P><D><S><K><L><G><Q><D><L><L><R><D><A><T><N><G><P><K><T><I><H><Q><L><V><L><E><H><F><L><T><F><L><P><K><P><S><L><V><Q><P><S><Q><K><V><K><E><T><L><V><I><M><K><D><V><S><S><S><L><Q><N><R><V><H><P><R><P><L><V><K><L><L><P><K><G><V><Q><K><E><Q><E><T><V><S><L><Y><L><K><A><N><P><E><E><L><V><V><F><E><D><L><N><V><F><H><C><Q><E><E><C><V><S><L><D><P><T><Q><Q><L><T><S><E><K><E><D><D><S><S><V><G><E><M><M><L><L><A><V><N><G><S><N><P><E><G><E><D><P><E><R><E><P><V><E><N><E><D><Y><R><E><K><S><S><D><D><D><E><M><D><S><S><L><V><S><Q><Q><P><P><D><N><Q><E><K><E><R><L><N><T><S><I><P><Q><K><R><K><M><R><N><L><L><V><T><I><E><N><D><T><P><L><E><E><L><S><K><Y><V><D><I><S><I><I><A><L><T><R><N><R><R><T><R><R><W><Y><T><C><P><L><C><G><K><Q><F><N><E><S><S><Y><L><I><S><H><Q><R><T><H><T><G><E><K><P><Y><D><C><N><H><C><G><K><S><F><N><H><K><T><N><L><N><K><H><E><R><I><H><T><G><E><K><P><Y><S><C><S><Q><C><G><K><N><F><R><Q><N><S><H><R><S><R><H><E><G><I><H><I><R><E><K><I><F><K><C><P><E><C><G><K><T><F><P><K><N><E><E><F><V><L><H><L><Q><S><H><E><A><E><R><P><Y><G><C><K><K><C><G><R><R><F><G><R><L><S><N><C><T><R><H><E><K><T><H><S><A><C><K><T><R><K><Q><K> | Could have a role in spermatogenesis.<BOP> | P98182 |
Q969G6 | RIFK_HUMAN | Flavokinase | Homo | <M><R><H><L><P><Y><F><C><R><G><Q><V><V><R><G><F><G><R><G><S><K><Q><L><G><I><P><T><A><N><F><P><E><Q><V><V><D><N><L><P><A><D><I><S><T><G><I><Y><Y><G><W><A><S><V><G><S><G><D><V><H><K><M><V><V><S><I><G><W><N><P><Y><Y><K><N><T><K><K><S><M><E><T><H><I><M><H><T><F><K><E><D><F><Y><G><E><I><L><N><V><A><I><V><G><Y><L><R><P><E><K><N><F><D><S><L><E><S><L><I><S><A><I><Q><G><D><I><E><E><A><K><K><R><L><E><L><P><E><H><L><K><I><K><E><D><N><F><F><Q><V><S><K><S><K><I><M><N><G><H> | Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.<BOP> | Q969G6 |
Q9H0Z9 | RBM38_HUMAN | ssDNA-binding protein SEB4 | Homo | <M><L><L><Q><P><A><P><C><A><P><S><A><G><F><P><R><P><L><A><A><P><G><A><M><H><G><S><Q><K><D><T><T><F><T><K><I><F><V><G><G><L><P><Y><H><T><T><D><A><S><L><R><K><Y><F><E><G><F><G><D><I><E><E><A><V><V><I><T><D><R><Q><T><G><K><S><R><G><Y><G><F><V><T><M><A><D><R><A><A><A><E><R><A><C><K><D><P><N><P><I><I><D><G><R><K><A><N><V><N><L><A><Y><L><G><A><K><P><R><S><L><Q><T><G><F><A><I><G><V><Q><Q><L><H><P><T><L><I><Q><R><T><Y><G><L><T><P><H><Y><I><Y><P><P><A><I><V><Q><P><S><V><V><I><P><A><A><P><V><P><S><L><S><S><P><Y><I><E><Y><T><P><A><S><P><A><Y><A><Q><Y><P><P><A><T><Y><D><Q><Y><P><Y><A><A><S><P><A><T><A><A><S><F><V><G><Y><S><Y><P><A><A><V><P><Q><A><L><S><A><A><A><P><A><G><T><T><F><V><Q><Y><Q><A><P><Q><L><Q><P><D><R><M><Q> | (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.<BOP> | Q9H0Z9 |
Q96D05 | F241B_HUMAN | Protein FAM241B | Homo | <M><V><R><I><L><A><N><G><E><I><V><Q><D><D><D><P><R><V><R><T><T><T><Q><P><P><R><G><S><I><P><R><Q><S><F><F><N><R><G><H><G><A><P><P><G><G><P><G><P><R><Q><Q><Q><A><G><A><R><L><G><A><A><Q><S><P><F><N><D><L><N><R><Q><L><V><N><M><G><F><P><Q><W><H><L><G><N><H><A><V><E><P><V><T><S><I><L><L><L><F><L><L><M><M><L><G><V><R><G><L><L><L><V><G><L><V><Y><L><V><S><H><L><S><Q><R> | May play a role in lysosome homeostasis.<BOP> | Q96D05 |
Q8N6M5 | ALLC_HUMAN | Allantoate amidinohydrolase | Homo | <M><D><M><A><S><E><S><V><G><G><K><I><L><F><A><T><D><D><F><F><A><P><A><E><N><L><I><K><S><D><S><P><C><F><K><E><H><E><Y><T><E><F><G><K><W><M><D><G><W><E><T><R><R><K><R><I><P><G><H><D><W><C><V><L><R><L><G><I><Q><G><V><I><R><G><F><D><V><D><V><S><Y><F><T><G><D><Y><A><P><R><V><S><I><Q><A><A><N><L><E><E><D><K><L><P><E><I><P><E><R><G><T><R><T><G><A><A><A><T><P><E><E><F><E><A><I><A><E><L><K><S><D><D><W><S><Y><L><V><P><M><T><E><L><K><P><G><N><P><A><S><G><H><N><Y><F><L><V><N><S><Q><Q><R><W><T><H><I><R><L><N><I><F><P><D><G><G><I><A><R><L><R><V><F><G><T><G><Q><K><D><W><T><A><T><D><P><K><E><P><A><D><L><V><A><I><A><F><G><G><V><C><V><G><F><S><N><A><K><F><G><H><P><N><N><I><I><G><V><G><G><A><K><S><M><A><D><G><W><E><T><A><R><R><L><D><R><P><P><I><L><E><N><D><E><N><G><I><L><L><V><P><G><C><E><W><A><V><F><R><L><A><H><P><G><V><I><T><R><I><E><I><D><T><K><Y><F><E><G><N><A><P><D><S><C><K><V><D><G><C><I><L><T><T><Q><E><E><E><A><V><I><R><Q><K><W><I><L><P><A><H><K><W><K><P><L><L><P><V><T><K><L><S><P><N><Q><S><H><L><F><D><S><L><T><L><E><L><Q><D><V><I><T><H><A><R><L><T><I><V><P><D><G><G><V><S><R><L><R><L><R><G><F><P><S><S><I><C><L><L><R><P><R><E><K><P><M><L><K><F><S><V><S><F><K><A><N><P> | The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.<BOP> | Q8N6M5 |
O75365 | TP4A3_HUMAN | Protein-tyrosine phosphatase of regenerating liver 3 | Homo | <M><A><R><M><N><R><P><A><P><V><E><V><S><Y><K><H><M><R><F><L><I><T><H><N><P><T><N><A><T><L><S><T><F><I><E><D><L><K><K><Y><G><A><T><T><V><V><R><V><C><E><V><T><Y><D><K><T><P><L><E><K><D><G><I><T><V><V><D><W><P><F><D><D><G><A><P><P><P><G><K><V><V><E><D><W><L><S><L><V><K><A><K><F><C><E><A><P><G><S><C><V><A><V><H><C><V><A><G><L><G><R><A><P><V><L><V><A><L><A><L><I><E><S><G><M><K><Y><E><D><A><I><Q><F><I><R><Q><K><R><R><G><A><I><N><S><K><Q><L><T><Y><L><E><K><Y><R><P><K><Q><R><L><R><F><K><D><P><H><T><H><K><T><R><C><C><V><M> | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<BOP> | O75365 |
Q9HCU9 | BRMS1_HUMAN | Breast cancer metastasis-suppressor 1 | Homo | <M><P><V><Q><P><P><S><K><D><T><E><E><M><E><A><E><G><D><S><A><A><E><M><N><G><E><E><E><E><S><E><E><E><R><S><G><S><Q><T><E><S><E><E><E><S><S><E><M><D><D><E><D><Y><E><R><R><R><S><E><C><V><S><E><M><L><D><L><E><K><Q><F><S><E><L><K><E><K><L><F><R><E><R><L><S><Q><L><R><L><R><L><E><E><V><G><A><E><R><A><P><E><Y><T><E><P><L><G><G><L><Q><R><S><L><K><I><R><I><Q><V><A><G><I><Y><K><G><F><C><L><D><V><I><R><N><K><Y><E><C><E><L><Q><G><A><K><Q><H><L><E><S><E><K><L><L><L><Y><D><T><L><Q><G><E><L><Q><E><R><I><Q><R><L><E><E><D><R><Q><S><L><D><L><S><S><E><W><W><D><D><K><L><H><A><R><G><S><S><R><S><W><D><S><L><P><P><S><K><R><K><K><A><P><L><V><S><G><P><Y><I><V><Y><M><L><Q><E><I><D><I><L><E><D><W><T><A><I><K><K><A><R><A><A><V><S><P><Q><K><R><K><S><D><G><P> | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<BOP> | Q9HCU9 |
Q96E93 | KLRG1_HUMAN | Mast cell function-associated antigen | Homo | <M><T><D><S><V><I><Y><S><M><L><E><L><P><T><A><T><Q><A><Q><N><D><Y><G><P><Q><Q><K><S><S><S><S><R><P><S><C><S><C><L><V><A><I><A><L><G><L><L><T><A><V><L><L><S><V><L><L><Y><Q><W><I><L><C><Q><G><S><N><Y><S><T><C><A><S><C><P><S><C><P><D><R><W><M><K><Y><G><N><H><C><Y><Y><F><S><V><E><E><K><D><W><N><S><S><L><E><F><C><L><A><R><D><S><H><L><L><V><I><T><D><N><Q><E><M><S><L><L><Q><V><F><L><S><E><A><F><C><W><I><G><L><R><N><N><S><G><W><R><W><E><D><G><S><P><L><N><F><S><R><I><S><S><N><S><F><V><Q><T><C><G><A><I><N><K><N><G><L><Q><A><S><S><C><E><V><P><L><H><W><V><C><K><K><C><P><F><A><D><Q><A><L><F> | Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.<BOP> | Q96E93 |
P28074 | PSB5_HUMAN | Proteasome subunit X | Homo | <M><A><L><A><S><V><L><E><R><P><L><P><V><N><Q><R><G><F><F><G><L><G><G><R><A><D><L><L><D><L><G><P><G><S><L><S><D><G><L><S><L><A><A><P><G><W><G><V><P><E><E><P><G><I><E><M><L><H><G><T><T><T><L><A><F><K><F><R><H><G><V><I><V><A><A><D><S><R><A><T><A><G><A><Y><I><A><S><Q><T><V><K><K><V><I><E><I><N><P><Y><L><L><G><T><M><A><G><G><A><A><D><C><S><F><W><E><R><L><L><A><R><Q><C><R><I><Y><E><L><R><N><K><E><R><I><S><V><A><A><A><S><K><L><L><A><N><M><V><Y><Q><Y><K><G><M><G><L><S><M><G><T><M><I><C><G><W><D><K><R><G><P><G><L><Y><Y><V><D><S><E><G><N><R><I><S><G><A><T><F><S><V><G><S><G><S><V><Y><A><Y><G><V><M><D><R><G><Y><S><Y><D><L><E><V><E><Q><A><Y><D><L><A><R><R><A><I><Y><Q><A><T><Y><R><D><A><Y><S><G><G><A><V><N><L><Y><H><V><R><E><D><G><W><I><R><V><S><S><D><N><V><A><D><L><H><E><K><Y><S><G><S><T><P> | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.<BOP> | P28074 |
Q96G28 | CFA36_HUMAN | Coiled-coil domain-containing protein 104 | Homo | <M><A><A><E><E><E><D><E><V><E><W><V><V><E><S><I><A><G><F><L><R><G><P><D><W><S><I><P><I><L><D><F><V><E><Q><K><C><E><V><F><D><D><E><E><E><S><K><L><T><Y><T><E><I><H><Q><E><Y><K><E><L><V><E><K><L><L><E><G><Y><L><K><E><I><G><I><N><E><D><Q><F><Q><E><A><C><T><S><P><L><A><K><T><H><T><S><Q><A><I><L><Q><P><V><L><A><A><E><D><F><T><I><F><K><A><M><M><V><Q><K><N><I><E><M><Q><L><Q><A><I><R><I><I><Q><E><R><N><G><V><L><P><D><C><L><T><D><G><S><D><V><V><S><D><L><E><H><E><E><M><K><I><L><R><E><V><L><R><K><S><K><E><E><Y><D><Q><E><E><E><R><K><R><K><K><Q><L><S><E><A><K><T><E><E><P><T><V><H><S><S><E><A><A><I><M><N><N><S><Q><G><D><G><E><H><F><A><H><P><P><S><E><V><K><M><H><F><A><N><Q><S><I><E><P><L><G><R><K><V><E><R><S><E><T><S><S><L><P><Q><K><D><L><K><I><P><G><L><E><H><A><S><I><E><G><P><I><A><N><L><S><V><L><G><T><E><E><L><R><Q><R><E><H><Y><L><K><Q><K><R><D><K><L><M><S><M><R><K><D><M><R><T><K><Q><I><Q><N><M><E><Q><K><G><K><P><T><G><E><V><E><E><M><T><E><K><P><E><M><T><A><E><E><K><Q><T><L><L><K><R><R><L><L><A><E><K><L><K><E><E><V><I><N><K> | May act as an effector for ARL3.<BOP> | Q96G28 |
P09466 | PAEP_HUMAN | Zona-binding inhibitory factor-1 | Homo | <M><L><C><L><L><L><T><L><G><V><A><L><V><C><G><V><P><A><M><D><I><P><Q><T><K><Q><D><L><E><L><P><K><L><A><G><T><W><H><S><M><A><M><A><T><N><N><I><S><L><M><A><T><L><K><A><P><L><R><V><H><I><T><S><L><L><P><T><P><E><D><N><L><E><I><V><L><H><R><W><E><N><N><S><C><V><E><K><K><V><L><G><E><K><T><E><N><P><K><K><F><K><I><N><Y><T><V><A><N><E><A><T><L><L><D><T><D><Y><D><N><F><L><F><L><C><L><Q><D><T><T><T><P><I><Q><S><M><M><C><Q><Y><L><A><R><V><L><V><E><D><D><E><I><M><Q><G><F><I><R><A><F><R><P><L><P><R><H><L><W><Y><L><L><D><L><K><Q><M><E><E><P><C><R><F> | Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities . Glycodelin-C stimulates binding of spermatozoa to the zona pellucida . Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa . Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa .<BOP> | P09466 |
Q9Y478 | AAKB1_HUMAN | 5'-AMP-activated protein kinase subunit beta-1 | Homo | <M><G><N><T><S><S><E><R><A><A><L><E><R><H><G><G><H><K><T><P><R><R><D><S><S><G><G><T><K><D><G><D><R><P><K><I><L><M><D><S><P><E><D><A><D><L><F><H><S><E><E><I><K><A><P><E><K><E><E><F><L><A><W><Q><H><D><L><E><V><N><D><K><A><P><A><Q><A><R><P><T><V><F><R><W><T><G><G><G><K><E><V><Y><L><S><G><S><F><N><N><W><S><K><L><P><L><T><R><S><H><N><N><F><V><A><I><L><D><L><P><E><G><E><H><Q><Y><K><F><F><V><D><G><Q><W><T><H><D><P><S><E><P><I><V><T><S><Q><L><G><T><V><N><N><I><I><Q><V><K><K><T><D><F><E><V><F><D><A><L><M><V><D><S><Q><K><C><S><D><V><S><E><L><S><S><S><P><P><G><P><Y><H><Q><E><P><Y><V><C><K><P><E><E><R><F><R><A><P><P><I><L><P><P><H><L><L><Q><V><I><L><N><K><D><T><G><I><S><C><D><P><A><L><L><P><E><P><N><H><V><M><L><N><H><L><Y><A><L><S><I><K><D><G><V><M><V><L><S><A><T><H><R><Y><K><K><K><Y><V><T><T><L><L><Y><K><P><I> | Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).<BOP> | Q9Y478 |
Q8N4T8 | CBR4_HUMAN | Short chain dehydrogenase/reductase family 45C member 1 | Homo | <M><D><K><V><C><A><V><F><G><G><S><R><G><I><G><R><A><V><A><Q><L><M><A><R><K><G><Y><R><L><A><V><I><A><R><N><L><E><G><A><K><A><A><A><G><D><L><G><G><D><H><L><A><F><S><C><D><V><A><K><E><H><D><V><Q><N><T><F><E><E><L><E><K><H><L><G><R><V><N><F><L><V><N><A><A><G><I><N><R><D><G><L><L><V><R><T><K><T><E><D><M><V><S><Q><L><H><T><N><L><L><G><S><M><L><T><C><K><A><A><M><R><T><M><I><Q><Q><Q><G><G><S><I><V><N><V><G><S><I><V><G><L><K><G><N><S><G><Q><S><V><Y><S><A><S><K><G><G><L><V><G><F><S><R><A><L><A><K><E><V><A><R><K><K><I><R><V><N><V><V><A><P><G><F><V><H><T><D><M><T><K><D><L><K><E><E><H><L><K><K><N><I><P><L><G><R><F><G><E><T><I><E><V><A><H><A><V><V><F><L><L><E><S><P><Y><I><T><G><H><V><L><V><V><D><G><G><L><Q><L><I><L> | Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis . The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones . As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) .<BOP> | Q8N4T8 |
Q9NX08 | COMD8_HUMAN | COMM domain-containing protein 8 | Homo | <M><E><P><E><E><G><T><P><L><W><R><L><Q><K><L><P><A><E><L><G><P><Q><L><L><H><K><I><I><D><G><I><C><G><R><A><Y><P><V><Y><Q><D><Y><H><T><V><W><E><S><E><E><W><M><H><V><L><E><D><I><A><K><F><F><K><A><I><V><G><K><N><L><P><D><E><E><I><F><Q><Q><L><N><Q><L><N><S><L><H><Q><E><T><I><M><K><C><V><K><S><R><K><D><E><I><K><Q><A><L><S><R><E><I><V><A><I><S><S><A><Q><L><Q><D><F><D><W><Q><V><K><L><A><L><S><S><D><K><I><A><A><L><R><M><P><L><L><S><L><H><L><D><V><K><E><N><G><E><V><K><P><Y><S><I><E><M><S><R><E><E><L><Q><N><L><I><Q><S><L><E><A><A><N><K><V><V><L><Q><L><K> | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . May down-regulate activation of NF-kappa-B .<BOP> | Q9NX08 |
Q9H322 | VCX2_HUMAN | Variably charged protein X-B | Homo | <M><S><P><K><P><R><A><S><G><P><P><A><K><A><T><E><A><G><K><R><K><S><S><S><Q><P><S><P><S><D><P><K><K><K><T><T><K><V><A><K><K><G><K><A><V><R><R><G><R><R><G><K><K><G><A><A><T><K><M><A><A><V><T><A><P><E><A><E><S><A><P><A><A><P><G><P><S><D><Q><P><S><Q><E><L><P><Q><H><E><L><P><P><E><E><P><V><S><E><G><T><Q><H><D><P><L><S><Q><E><S><E><V><E><E><P><L><S><Q><E><S><E><V><E><E><P><L><T><V><W><M><A><S><F><S><P><V><S><E><S><T><D> | May mediate a process in spermatogenesis or may play a role in sex ratio distortion.<BOP> | Q9H322 |
P17027 | ZNF23_HUMAN | Zinc finger protein KOX16 | Homo | <M><L><E><N><Y><G><N><V><A><S><L><G><F><P><L><L><K><P><A><V><I><S><Q><L><E><G><G><S><E><L><G><G><S><S><P><L><A><A><G><T><G><L><Q><G><L><Q><T><D><I><Q><T><D><N><D><L><T><K><E><M><Y><E><G><K><E><N><V><S><F><E><L><Q><R><D><F><S><Q><E><T><D><F><S><E><A><S><L><L><E><K><Q><Q><E><V><H><S><A><G><N><I><K><K><E><K><S><N><T><I><D><G><T><V><K><D><E><T><S><P><V><E><E><C><F><F><S><Q><S><S><N><S><Y><Q><C><H><T><I><T><G><E><Q><P><S><G><C><T><G><L><G><K><S><I><S><F><D><T><K><L><V><K><H><E><I><I><N><S><E><E><R><P><F><K><C><E><E><L><V><E><P><F><R><C><D><S><Q><L><I><Q><H><Q><E><N><N><T><E><E><K><P><Y><Q><C><S><E><C><G><K><A><F><S><I><N><E><K><L><I><W><H><Q><R><L><H><S><G><E><K><P><F><K><C><V><E><C><G><K><S><F><S><Y><S><S><H><Y><I><T><H><Q><T><I><H><S><G><E><K><P><Y><Q><C><K><M><C><G><K><A><F><S><V><N><G><S><L><S><R><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><N><G><F><S><C><S><S><A><Y><I><T><H><Q><R><V><H><T><G><E><K><P><Y><E><C><N><D><C><G><K><A><F><N><V><N><A><K><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><G><F><R><C><S><S><Q><L><R><Q><H><Q><S><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><G><F><N><N><N><T><K><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><T><E><C><G><K><A><F><S><V><K><G><K><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><R><C><N><S><Q><F><R><Q><H><L><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><V><N><G><K><L><M><R><H><Q><R><I><H><T><G><E><K><P><F><E><C><N><E><C><G><R><C><F><T><S><K><R><N><L><L><D><H><H><R><I><H><T><G><E><K><P><Y><Q><C><K><E><C><G><K><A><F><S><I><N><A><K><L><T><R><H><Q><R><I><H><T><G><E><K><P><F><K><C><M><E><C><E><K><A><F><S><C><S><S><N><Y><I><V><H><Q><R><I><H><T><G><E><K><P><F><Q><C><K><E><C><G><K><A><F><H><V><N><A><H><L><I><R><H><Q><R><S><H><T><G><E><K><P><F><R><C><V><E><C><G><K><G><F><S><F><S><S><D><Y><I><I><H><Q><T><V><H><T><W><K><K><P><Y><M><C><S><V><C><G><K><A><F><R><F><S><F><Q><L><S><Q><H><Q><S><V><H><S><E><G><K><S> | May be involved in transcriptional regulation. May have a role in embryonic development.<BOP> | P17027 |
O76099 | OR7C1_HUMAN | Olfactory receptor TPCR86 | Homo | <M><E><T><G><N><Q><T><H><A><Q><E><F><L><L><L><G><F><S><A><T><S><E><I><Q><F><I><L><F><G><L><F><L><S><M><Y><L><V><T><F><T><G><N><L><L><I><I><L><A><I><C><S><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><A><D><L><C><F><T><S><T><T><V><P><K><M><L><L><N><I><L><T><Q><N><K><F><I><T><Y><A><G><C><L><S><Q><I><F><F><F><T><S><F><G><C><L><D><N><L><L><L><T><V><M><A><Y><D><R><F><V><A><V><C><H><P><L><H><Y><T><V><I><M><N><P><Q><L><C><G><L><L><V><L><G><S><W><C><I><S><V><M><G><S><L><L><E><T><L><T><V><L><R><L><S><F><C><T><E><M><E><I><P><H><F><F><C><D><L><L><E><V><L><K><L><A><C><S><D><T><F><I><N><N><V><V><I><Y><F><A><T><G><V><L><G><V><I><S><F><T><G><I><F><F><S><Y><Y><K><I><V><F><S><I><L><R><I><S><S><A><G><R><K><H><K><A><F><S><T><C><G><S><H><L><S><V><V><T><L><F><Y><G><T><G><F><G><V><Y><L><S><S><A><A><T><P><S><S><R><T><S><L><V><A><S><V><M><Y><T><M><V><T><P><M><L><N><P><F><I><Y><S><L><R><N><T><D><M><K><R><A><L><G><R><L><L><S><R><A><T><F><F><N><G><D><I><T><A><G><L><S> | Odorant receptor.<BOP> | O76099 |
Q9Y6F7 | CDY2_HUMAN | Testis-specific chromodomain protein Y 2 | Homo | <M><A><S><Q><E><F><E><V><E><A><I><V><D><K><R><Q><D><K><N><G><N><T><Q><Y><L><V><R><W><K><G><Y><D><K><Q><D><D><T><W><E><P><E><Q><H><L><M><N><C><E><K><C><V><H><D><F><N><R><R><Q><T><E><K><Q><K><K><L><T><W><T><T><T><S><R><I><F><S><N><N><A><R><R><R><T><S><R><S><T><K><A><N><Y><S><K><N><S><P><K><T><P><V><T><D><K><H><H><R><S><K><N><C><K><L><F><A><A><S><K><N><V><R><R><K><A><A><S><T><L><S><D><T><K><N><M><E><I><I><N><S><T><I><E><T><L><A><P><D><S><P><F><D><H><K><K><T><V><S><G><F><Q><K><L><E><K><L><D><P><I><A><A><D><Q><Q><D><T><V><V><F><K><V><T><E><G><K><L><L><R><D><P><L><S><H><P><G><A><E><Q><T><G><I><Q><N><K><T><Q><M><H><P><L><M><S><Q><M><S><G><S><V><T><A><S><M><A><T><G><S><A><T><R><K><G><I><V><V><L><I><D><P><L><A><A><N><G><T><T><D><M><H><T><S><V><P><R><V><K><G><G><Q><R><N><I><T><D><D><S><R><G><Q><P><F><I><K><K><M><H><F><T><I><R><L><T><E><S><A><I><T><Y><R><D><I><V><V><K><K><E><D><G><F><T><Q><I><V><L><S><T><R><S><T><E><K><N><A><L><N><T><E><V><I><K><E><M><V><N><A><L><N><S><A><A><A><D><D><S><K><L><V><L><F><S><A><A><G><S><V><F><C><C><G><L><D><F><G><Y><F><V><R><H><L><R><N><D><R><N><T><A><S><L><E><M><V><D><T><I><K><N><F><V><N><T><F><I><Q><F><K><K><P><I><V><V><S><V><N><G><P><A><I><G><L><G><A><S><I><L><P><L><C><D><L><V><W><A><N><E><K><A><W><F><Q><T><P><Y><T><T><F><G><Q><S><P><D><G><C><S><S><I><T><F><P><K><M><M><G><K><A><S><A><N><E><M><L><I><A><G><R><K><L><T><A><R><E><A><C><A><K><G><L><V><S><Q><V><F><L><T><G><T><F><T><Q><E><V><M><I><Q><I><K><E><L><A><S><Y><N><A><I><V><L><E><E><C><K><A><L><V><R><C><N><I><K><L><E><L><E><Q><A><N><E><R><E><C><E><V><L><R><K><I><W><S><S><A><Q><G><I><E><S><M><L><K><Y><V><E><N><K><I><D><E><F> | May have histone acetyltransferase activity.<BOP> | Q9Y6F7 |
P09067 | HXB5_HUMAN | Homeobox protein Hu-1 | Homo | <M><S><S><Y><F><V><N><S><F><S><G><R><Y><P><N><G><P><D><Y><Q><L><L><N><Y><G><S><G><S><S><L><S><G><S><Y><R><D><P><A><A><M><H><T><G><S><Y><G><Y><N><Y><N><G><M><D><L><S><V><N><R><S><S><A><S><S><S><H><F><G><A><V><G><E><S><S><R><A><F><P><A><P><A><Q><E><P><R><F><R><Q><A><A><S><S><C><S><L><S><S><P><E><S><L><P><C><T><N><G><D><S><H><G><A><K><P><S><A><S><S><P><S><D><Q><A><T><S><A><S><S><S><A><N><F><T><E><I><D><E><A><S><A><S><S><E><P><E><E><A><A><S><Q><L><S><S><P><S><L><A><R><A><Q><P><E><P><M><A><T><S><T><A><A><P><E><G><Q><T><P><Q><I><F><P><W><M><R><K><L><H><I><S><H><D><M><T><G><P><D><G><K><R><A><R><T><A><Y><T><R><Y><Q><T><L><E><L><E><K><E><F><H><F><N><R><Y><L><T><R><R><R><R><I><E><I><A><H><A><L><C><L><S><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><W><K><K><D><N><K><L><K><S><M><S><L><A><T><A><G><S><A><F><Q><P> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P09067 |
Q9BY15 | AGRE3_HUMAN | EGF-like module-containing mucin-like hormone receptor-like 3 | Homo | <M><Q><G><P><L><L><L><P><G><L><C><F><L><L><S><L><F><G><A><V><T><Q><K><T><K><T><S><C><A><K><C><P><P><N><A><S><C><V><N><N><T><H><C><T><C><N><H><G><Y><T><S><G><S><G><Q><K><L><F><T><F><P><L><E><T><C><N><D><I><N><E><C><T><P><P><Y><S><V><Y><C><G><F><N><A><V><C><Y><N><V><E><G><S><F><Y><C><Q><C><V><P><G><Y><R><L><H><S><G><N><E><Q><F><S><N><S><N><E><N><T><C><Q><D><T><T><S><S><K><T><T><E><G><R><K><E><L><Q><K><I><V><D><K><F><E><S><L><L><T><N><Q><T><L><W><R><T><E><G><R><Q><E><I><S><S><T><A><T><T><I><L><R><D><V><E><S><K><V><L><E><T><A><L><K><D><P><E><Q><K><V><L><K><I><Q><N><D><S><V><A><I><E><T><Q><A><I><T><D><N><C><S><E><E><R><K><T><F><N><L><N><V><Q><M><N><S><M><D><I><R><C><S><D><I><I><Q><G><D><T><Q><G><P><S><A><I><A><F><I><S><Y><S><S><L><G><N><I><I><N><A><T><F><F><E><E><M><D><K><K><D><Q><V><Y><L><N><S><Q><V><V><S><A><A><I><G><P><K><R><N><V><S><L><S><K><S><V><T><L><T><F><Q><H><V><K><M><T><P><S><T><K><K><V><F><C><V><Y><W><K><S><T><G><Q><G><S><Q><W><S><R><D><G><C><F><L><I><H><V><N><K><S><H><T><M><C><N><C><S><H><L><S><S><F><A><V><L><M><A><L><T><S><Q><E><E><D><P><V><L><T><V><I><T><Y><V><G><L><S><V><S><L><L><C><L><L><L><A><A><L><T><F><L><L><C><K><A><I><R><N><T><S><T><S><L><H><L><Q><L><S><L><C><L><F><L><A><H><L><L><F><L><V><G><I><D><R><T><E><P><K><V><L><C><S><I><I><A><G><A><L><H><Y><L><Y><L><A><A><F><T><W><M><L><L><E><G><V><H><L><F><L><T><A><R><N><L><T><V><V><N><Y><S><S><I><N><R><L><M><K><W><I><M><F><P><V><G><Y><G><V><P><A><V><T><V><A><I><S><A><A><S><W><P><H><L><Y><G><T><A><D><R><C><W><L><H><L><D><Q><G><F><M><W><S><F><L><G><P><V><C><A><I><F><S><A><N><L><V><L><F><I><L><V><F><W><I><L><K><R><K><L><S><S><L><N><S><E><V><S><T><I><Q><N><T><R><M><L><A><F><K><A><T><A><Q><L><F><I><L><G><C><T><W><C><L><G><L><L><Q><V><G><P><A><A><Q><V><M><A><Y><L><F><T><I><I><N><S><L><Q><G><F><F><I><F><L><V><Y><C><L><L><S><Q><Q><V><Q><K><Q><Y><Q><K><W><F><R><E><I><V><K><S><K><S><E><S><E><T><Y><T><L><S><S><K><M><G><P><D><S><K><P><S><E><G><D><V><F><P><G><Q><V><K><R><K><Y> | Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.<BOP> | Q9BY15 |
Q8TB61 | S35B2_HUMAN | Solute carrier family 35 member B2 | Homo | <M><D><A><R><W><W><A><V><V><V><L><A><A><F><P><S><L><G><A><G><G><E><T><P><E><A><P><P><E><S><W><T><Q><L><W><F><F><R><F><V><V><N><A><A><G><Y><A><S><F><M><V><P><G><Y><L><L><V><Q><Y><F><R><R><K><N><Y><L><E><T><G><R><G><L><C><F><P><L><V><K><A><C><V><F><G><N><E><P><K><A><S><D><E><V><P><L><A><P><R><T><E><A><A><E><T><T><P><M><W><Q><A><L><K><L><L><F><C><A><T><G><L><Q><V><S><Y><L><T><W><G><V><L><Q><E><R><V><M><T><R><S><Y><G><A><T><A><T><S><P><G><E><R><F><T><D><S><Q><F><L><V><L><M><N><R><V><L><A><L><I><V><A><G><L><S><C><V><L><C><K><Q><P><R><H><G><A><P><M><Y><R><Y><S><F><A><S><L><S><N><V><L><S><S><W><C><Q><Y><E><A><L><K><F><V><S><F><P><T><Q><V><L><A><K><A><S><K><V><I><P><V><M><L><M><G><K><L><V><S><R><R><S><Y><E><H><W><E><Y><L><T><A><T><L><I><S><I><G><V><S><M><F><L><L><S><S><G><P><E><P><R><S><S><P><A><T><T><L><S><G><L><I><L><L><A><G><Y><I><A><F><D><S><F><T><S><N><W><Q><D><A><L><F><A><Y><K><M><S><S><V><Q><M><M><F><G><V><N><F><F><S><C><L><F><T><V><G><S><L><L><E><Q><G><A><L><L><E><G><T><R><F><M><G><R><H><S><E><F><A><A><H><A><L><L><L><S><I><C><S><A><C><G><Q><L><F><I><F><Y><T><I><G><Q><F><G><A><A><V><F><T><I><I><M><T><L><R><Q><A><F><A><I><L><L><S><C><L><L><Y><G><H><T><V><T><V><V><G><G><L><G><V><A><V><V><F><A><A><L><L><L><R><V><Y><A><R><G><R><L><K><Q><R><G><K><K><A><V><P><V><E><S><P><V><Q><K><V> | Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.<BOP> | Q8TB61 |
Q9H161 | ALX4_HUMAN | Homeobox protein aristaless-like 4 | Homo | <M><N><A><E><T><C><V><S><Y><C><E><S><P><A><A><A><M><D><A><Y><Y><S><P><V><S><Q><S><R><E><G><S><S><P><F><R><A><F><P><G><G><D><K><F><G><T><T><F><L><S><A><A><A><K><A><Q><G><F><G><D><A><K><S><R><A><R><Y><G><A><G><Q><Q><D><L><A><T><P><L><E><S><G><A><G><A><R><G><S><F><N><K><F><Q><P><Q><P><S><T><P><Q><P><Q><P><P><P><Q><P><Q><P><Q><Q><Q><Q><P><Q><P><Q><P><P><A><Q><P><H><L><Y><L><Q><R><G><A><C><K><T><P><P><D><G><S><L><K><L><Q><E><G><S><S><G><H><S><A><A><L><Q><V><P><C><Y><A><K><E><S><S><L><G><E><P><E><L><P><P><D><S><D><T><V><G><M><D><S><S><Y><L><S><V><K><E><A><G><V><K><G><P><Q><D><R><A><S><S><D><L><P><S><P><L><E><K><A><D><S><E><S><N><K><G><K><K><R><R><N><R><T><T><F><T><S><Y><Q><L><E><E><L><E><K><V><F><Q><K><T><H><Y><P><D><V><Y><A><R><E><Q><L><A><M><R><T><D><L><T><E><A><R><V><Q><V><W><F><Q><N><R><R><A><K><W><R><K><R><E><R><F><G><Q><M><Q><Q><V><R><T><H><F><S><T><A><Y><E><L><P><L><L><T><R><A><E><N><Y><A><Q><I><Q><N><P><S><W><L><G><N><N><G><A><A><S><P><V><P><A><C><V><V><P><C><D><P><V><P><A><C><M><S><P><H><A><H><P><P><G><S><G><A><S><S><V><T><D><F><L><S><V><S><G><A><G><S><H><V><G><Q><T><H><M><G><S><L><F><G><A><A><S><L><S><P><G><L><N><G><Y><E><L><N><G><E><P><D><R><K><T><S><S><I><A><A><L><R><M><K><A><K><E><H><S><A><A><I><S><W><A><T> | Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.<BOP> | Q9H161 |
O75663 | TIPRL_HUMAN | Type 2A-interacting protein | Homo | <M><M><I><H><G><F><Q><S><S><H><R><D><F><C><F><G><P><W><K><L><T><A><S><K><T><H><I><M><K><S><A><D><V><E><K><L><A><D><E><L><H><M><P><S><L><P><E><M><M><F><G><D><N><V><L><R><I><Q><H><G><S><G><F><G><I><E><F><N><A><T><D><A><L><R><C><V><N><N><Y><Q><G><M><L><K><V><A><C><A><E><E><W><Q><E><S><R><T><E><G><E><H><S><K><E><V><I><K><P><Y><D><W><T><Y><T><T><D><Y><K><G><T><L><L><G><E><S><L><K><L><K><V><V><P><T><T><D><H><I><D><T><E><K><L><K><A><R><E><Q><I><K><F><F><E><E><V><L><L><F><E><D><E><L><H><D><H><G><V><S><S><L><S><V><K><I><R><V><M><P><S><S><F><F><L><L><L><R><F><F><L><R><I><D><G><V><L><I><R><M><N><D><T><R><L><Y><H><E><A><D><K><T><Y><M><L><R><E><Y><T><S><R><E><S><K><I><S><S><L><M><H><V><P><P><S><L><F><T><E><P><N><E><I><S><Q><Y><L><P><I><K><E><A><V><C><E><K><L><I><F><P><E><R><I><D><P><N><P><A><D><S><Q><K><S><T><Q><V><E> | May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.<BOP> | O75663 |
Q8IYI6 | EXOC8_HUMAN | Exocyst complex 84 kDa subunit | Homo | <M><A><M><A><M><S><D><S><G><A><S><R><L><R><R><Q><L><E><S><G><G><F><E><A><R><L><Y><V><K><Q><L><S><Q><Q><S><D><G><D><R><D><L><Q><E><H><R><Q><R><I><Q><A><L><A><E><E><T><A><Q><N><L><K><R><N><V><Y><Q><N><Y><R><Q><F><I><E><T><A><R><E><I><S><Y><L><E><S><E><M><Y><Q><L><S><H><L><L><T><E><Q><K><S><S><L><E><S><I><P><L><T><L><L><P><A><A><A><A><A><G><A><A><A><A><S><G><G><E><E><G><V><G><G><A><G><G><R><D><H><L><R><G><Q><A><G><F><F><S><T><P><G><G><A><S><R><D><G><S><G><P><G><E><E><G><K><Q><R><T><L><T><T><L><L><E><K><V><E><G><C><R><H><L><L><E><T><P><G><Q><Y><L><V><Y><N><G><D><L><V><E><Y><D><A><D><H><M><A><Q><L><Q><R><V><H><G><F><L><M><N><D><C><L><L><V><A><T><W><L><P><Q><R><R><G><M><Y><R><Y><N><A><L><Y><S><L><D><G><L><A><V><V><N><V><K><D><N><P><P><M><K><D><M><F><K><L><L><M><F><P><E><S><R><I><F><Q><A><E><N><A><K><I><K><R><E><W><L><E><V><L><E><D><T><K><R><A><L><S><E><K><R><R><R><E><Q><E><E><A><A><A><P><R><G><P><P><Q><V><T><S><K><A><T><N><P><F><E><D><D><E><E><E><E><P><A><V><P><E><V><E><E><E><K><V><D><L><S><M><E><W><I><Q><E><L><P><E><D><L><D><V><C><I><A><Q><R><D><F><E><G><A><V><D><L><L><D><K><L><N><H><Y><L><E><D><K><P><S><P><P><P><V><K><E><L><R><A><K><V><E><E><R><V><R><Q><L><T><E><V><L><V><F><E><L><S><P><D><R><S><L><R><G><G><P><K><A><T><R><R><A><V><S><Q><L><I><R><L><G><Q><C><T><K><A><C><E><L><F><L><R><N><R><A><A><A><V><H><T><A><I><R><Q><L><R><I><E><G><A><T><L><L><Y><I><H><K><L><C><H><V><F><F><T><S><L><L><E><T><A><R><E><F><E><I><D><F><A><G><T><D><S><G><C><Y><S><A><F><V><V><W><A><R><S><A><M><G><M><F><V><D><A><F><S><K><Q><V><F><D><S><K><E><S><L><S><T><A><A><E><C><V><K><V><A><K><E><H><C><Q><Q><L><G><D><I><G><L><D><L><T><F><I><I><H><A><L><L><V><K><D><I><Q><G><A><L><H><S><Y><K><E><I><I><I><E><A><T><K><H><R><N><S><E><E><M><W><R><R><M><N><L><M><T><P><E><A><L><G><K><L><K><E><E><M><K><S><C><G><V><S><N><F><E><Q><Y><T><G><D><D><C><W><V><N><L><S><Y><T><V><V><A><F><T><K><Q><T><M><G><F><L><E><E><A><L><K><L><Y><F><P><E><L><H><M><V><L><L><E><S><L><V><E><I><I><L><V><A><V><Q><H><V><D><Y><S><L><R><C><E><Q><D><P><E><K><K><A><F><I><R><Q><N><A><S><F><L><Y><E><T><V><L><P><V><V><E><K><R><F><E><E><G><V><G><K><P><A><K><Q><L><Q><D><L><R><N><A><S><R><L><I><R><V><N><P><E><S><T><T><S><V><V> | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.<BOP> | Q8IYI6 |
Q14254 | FLOT2_HUMAN | Membrane component chromosome 17 surface marker 1 | Homo | <M><G><N><C><H><T><V><G><P><N><E><A><L><V><V><S><G><G><C><C><G><S><D><Y><K><Q><Y><V><F><G><G><W><A><W><A><W><W><C><I><S><D><T><Q><R><I><S><L><E><I><M><T><L><Q><P><R><C><E><D><V><E><T><A><E><G><V><A><L><T><V><T><G><V><A><Q><V><K><I><M><T><E><K><E><L><L><A><V><A><C><E><Q><F><L><G><K><N><V><Q><D><I><K><N><V><V><L><Q><T><L><E><G><H><L><R><S><I><L><G><T><L><T><V><E><Q><I><Y><Q><D><R><D><Q><F><A><K><L><V><R><E><V><A><A><P><D><V><G><R><M><G><I><E><I><L><S><F><T><I><K><D><V><Y><D><K><V><D><Y><L><S><S><L><G><K><T><Q><T><A><V><V><Q><R><D><A><D><I><G><V><A><E><A><E><R><D><A><G><I><R><E><A><E><C><K><K><E><M><L><D><V><K><F><M><A><D><T><K><I><A><D><S><K><R><A><F><E><L><Q><K><S><A><F><S><E><E><V><N><I><K><T><A><E><A><Q><L><A><Y><E><L><Q><G><A><R><E><Q><Q><K><I><R><Q><E><E><I><E><I><E><V><V><Q><R><K><K><Q><I><A><V><E><A><Q><E><I><L><R><T><D><K><E><L><I><A><T><V><R><R><P><A><E><A><E><A><H><R><I><Q><Q><I><A><E><G><E><K><V><K><Q><V><L><L><A><Q><A><E><A><E><K><I><R><K><I><G><E><A><E><A><A><V><I><E><A><M><G><K><A><E><A><E><R><M><K><L><K><A><E><A><Y><Q><K><Y><G><D><A><A><K><M><A><L><V><L><E><A><L><P><Q><I><A><A><K><I><A><A><P><L><T><K><V><D><E><I><V><V><L><S><G><D><N><S><K><V><T><S><E><V><N><R><L><L><A><E><L><P><A><S><V><H><A><L><T><G><V><D><L><S><K><I><P><L><I><K><K><A><T><G><V><Q><V> | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.<BOP> | Q14254 |
P51522 | ZNF83_HUMAN | Zinc finger protein HPF1 | Homo | <M><H><G><R><K><D><D><A><Q><K><Q><P><V><K><N><Q><L><G><L><N><P><Q><S><H><L><P><E><L><Q><L><F><Q><A><E><G><K><I><Y><K><Y><D><H><M><E><K><S><V><N><S><S><S><L><V><S><P><P><Q><R><I><S><S><T><V><K><T><H><I><S><H><T><Y><E><C><N><F><V><D><S><L><F><T><Q><K><E><K><A><N><I><G><T><E><H><Y><K><C><S><E><R><G><K><A><F><H><Q><G><L><H><F><T><I><H><Q><I><I><H><T><K><E><T><Q><F><K><C><D><I><C><G><K><I><F><N><K><K><S><N><L><A><S><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><H><N><M><S><H><L><A><Q><H><R><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><N><Q><I><S><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><H><Q><I><S><H><L><A><Q><H><R><T><I><H><T><G><E><K><P><Y><E><C><N><K><C><G><K><V><F><S><R><N><S><Y><L><V><Q><H><L><I><I><H><T><G><E><K><P><Y><R><C><N><V><C><G><K><V><F><H><H><I><S><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><S><H><K><S><S><L><V><N><H><W><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><S><H><K><S><S><L><V><N><H><W><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><V><F><S><R><N><S><Y><L><A><Q><H><L><I><I><H><A><G><E><K><P><Y><K><C><D><E><C><D><K><A><F><S><Q><N><S><H><L><V><Q><H><H><R><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><V><F><S><Q><N><S><Y><L><A><Y><H><W><R><I><H><T><G><E><K><A><Y><K><C><N><E><C><G><K><V><F><G><L><N><S><S><L><A><H><H><R><K><I><H><T><G><E><K><P><F><K><C><N><E><C><G><K><A><F><S><M><R><S><S><L><T><N><H><H><A><I><H><T><G><E><K><H><F><K><C><N><E><C><G><K><L><F><R><D><N><S><Y><L><V><R><H><Q><R><F><H><A><G><K><K><S><N><T><C><N> | May be involved in transcriptional regulation.<BOP> | P51522 |
Q9UBU8 | MO4L1_HUMAN | Transcription factor-like protein MRG15 | Homo | <M><A><P><K><Q><D><P><K><P><K><F><Q><E><G><E><R><V><L><C><F><H><G><P><L><L><Y><E><A><K><C><V><K><V><A><I><K><D><K><Q><V><K><Y><F><I><H><Y><S><G><W><N><K><K><S><A><V><R><P><R><R><S><E><K><S><L><K><T><H><E><D><I><V><A><L><F><P><V><P><E><G><A><P><S><V><H><H><P><L><L><T><S><S><W><D><E><W><V><P><E><S><R><V><L><K><Y><V><D><T><N><L><Q><K><Q><R><E><L><Q><K><A><N><Q><E><Q><Y><A><E><G><K><M><R><G><A><A><P><G><K><K><T><S><G><L><Q><Q><K><N><V><E><V><K><T><K><K><N><K><Q><K><T><P><G><N><G><D><G><G><S><T><S><E><T><P><Q><P><P><R><K><K><R><A><R><V><D><P><T><V><E><N><E><E><T><F><M><N><R><V><E><V><K><V><K><I><P><E><E><L><K><P><W><L><V><D><D><W><D><L><I><T><R><Q><K><Q><L><F><Y><L><P><A><K><K><N><V><D><S><I><L><E><D><Y><A><N><Y><K><K><S><R><G><N><T><D><N><K><E><Y><A><V><N><E><V><V><A><G><I><K><E><Y><F><N><V><M><L><G><T><Q><L><L><Y><K><F><E><R><P><Q><Y><A><E><I><L><A><D><H><P><D><A><P><M><S><Q><V><Y><G><A><P><H><L><L><R><L><F><V><R><I><G><A><M><L><A><Y><T><P><L><D><E><K><S><L><A><L><L><L><N><Y><L><H><D><F><L><K><Y><L><A><K><N><S><A><T><L><F><S><A><S><D><Y><E><V><A><P><P><E><Y><H><R><K><A><V> | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. | Q9UBU8 |
Q3LI73 | KR194_HUMAN | Keratin-associated protein 19-4 | Homo | <M><S><Y><Y><G><S><Y><Y><R><G><L><G><Y><G><C><G><G><F><G><G><L><G><Y><G><Y><G><C><G><C><G><S><F><R><R><L><G><Y><G><C><G><F><G><G><N><G><Y><G><Y><C><R><P><S><C><Y><G><G><Y><G><F><S><I><L><L><K><S><Y><P><E><D><T><I><S><E><V><I><R><R><S><F><N><L><T><K><Y> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q3LI73 |
Q5HYK3 | COQ5_HUMAN | Ubiquinone biosynthesis methyltransferase COQ5 | Homo | <M><A><A><P><G><S><C><A><L><W><S><Y><C><G><R><G><W><S><R><A><M><R><G><C><Q><L><L><G><L><R><S><S><W><P><G><D><L><L><S><A><R><L><L><S><Q><E><K><R><A><A><E><T><H><F><G><F><E><T><V><S><E><E><E><K><G><G><K><V><Y><Q><V><F><E><S><V><A><K><K><Y><D><V><M><N><D><M><M><S><L><G><I><H><R><V><W><K><D><L><L><L><W><K><M><H><P><L><P><G><T><Q><L><L><D><V><A><G><G><T><G><D><I><A><F><R><F><L><N><Y><V><Q><S><Q><H><Q><R><K><Q><K><R><Q><L><R><A><Q><Q><N><L><S><W><E><E><I><A><K><E><Y><Q><N><E><E><D><S><L><G><G><S><R><V><V><V><C><D><I><N><K><E><M><L><K><V><G><K><Q><K><A><L><A><Q><G><Y><R><A><G><L><A><W><V><L><G><D><A><E><E><L><P><F><D><D><D><K><F><D><I><Y><T><I><A><F><G><I><R><N><V><T><H><I><D><Q><A><L><Q><E><A><H><R><V><L><K><P><G><G><R><F><L><C><L><E><F><S><Q><V><N><N><P><L><I><S><R><L><Y><D><L><Y><S><F><Q><V><I><P><V><L><G><E><V><I><A><G><D><W><K><S><Y><Q><Y><L><V><E><S><I><R><R><F><P><S><Q><E><E><F><K><D><M><I><E><D><A><G><F><H><K><V><T><Y><E><S><L><T><S><G><I><V><A><I><H><S><G><F><K><L> | Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).<BOP> | Q5HYK3 |
Q3SY52 | ZIK1_HUMAN | Zinc finger protein 762 | Homo | <M><A><A><A><A><L><R><A><P><T><Q><V><T><V><S><P><E><T><H><M><D><L><T><K><G><C><V><T><F><E><D><I><A><I><Y><F><S><Q><D><E><W><G><L><L><D><E><A><Q><R><L><L><Y><L><E><V><M><L><E><N><F><A><L><V><A><S><L><G><C><G><H><G><T><E><D><E><E><T><P><S><D><Q><N><V><S><V><G><V><S><Q><S><K><A><G><S><S><T><Q><K><T><Q><S><C><E><M><C><V><P><V><L><K><D><I><L><H><L><A><D><L><P><G><Q><K><P><Y><L><V><G><E><C><T><N><H><H><Q><H><Q><K><H><H><S><A><K><K><S><L><K><R><D><M><D><R><A><S><Y><V><K><C><C><L><F><C><M><S><L><K><P><F><R><K><W><E><V><G><K><D><L><P><A><M><L><R><L><L><R><S><L><V><F><P><G><G><K><K><P><G><T><I><T><E><C><G><E><D><I><R><S><Q><K><S><H><Y><K><S><G><E><C><G><K><A><S><R><H><K><H><T><P><V><Y><H><P><R><V><Y><T><G><K><K><L><Y><E><C><S><K><C><G><K><A><F><R><G><K><Y><S><L><V><Q><H><Q><R><V><H><T><G><E><R><P><W><E><C><N><E><C><G><K><F><F><S><Q><T><S><H><L><N><D><H><R><R><I><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><L><F><R><Q><N><S><S><L><V><D><H><Q><K><I><H><T><G><A><R><P><Y><E><C><S><Q><C><G><K><S><F><S><Q><K><A><T><L><V><K><H><Q><R><V><H><T><G><E><R><P><Y><K><C><G><E><C><G><N><S><F><S><Q><S><A><I><L><N><Q><H><R><R><I><H><T><G><A><K><P><Y><E><C><G><Q><C><G><K><S><F><S><Q><K><A><T><L><I><K><H><Q><R><V><H><T><G><E><R><P><Y><K><C><G><D><C><G><K><S><F><S><Q><S><S><I><L><I><Q><H><R><R><I><H><T><G><A><R><P><Y><E><C><G><Q><C><G><K><S><F><S><Q><K><S><G><L><I><Q><H><Q><V><V><H><T><G><E><R><P><Y><E><C><N><K><C><G><N><S><F><S><Q><C><S><S><L><I><H><H><Q><K><C><H><N><T> | May be a transcriptional repressor.<BOP> | Q3SY52 |
Q8NGF7 | OR5BH_HUMAN | Olfactory receptor OR11-237 | Homo | <M><E><N><N><T><E><V><S><E><F><I><L><L><G><L><T><N><A><P><E><L><Q><V><P><L><F><I><M><F><T><L><I><Y><L><I><T><L><T><G><N><L><G><M><I><I><L><I><L><L><D><S><H><L><H><T><P><M><Y><F><F><L><S><N><L><S><L><A><G><I><G><Y><S><S><A><V><T><P><K><V><L><T><G><L><L><I><E><D><K><A><I><S><Y><S><A><C><A><A><Q><M><F><F><C><A><V><F><A><T><V><E><N><Y><L><L><S><S><M><A><Y><D><R><Y><A><A><V><C><N><P><L><H><Y><T><T><T><M><T><T><R><V><C><A><C><L><A><I><G><C><Y><V><I><G><F><L><N><A><S><I><Q><I><G><D><T><F><R><L><S><F><C><M><S><N><V><I><H><H><F><F><C><D><K><P><A><V><I><T><L><T><C><S><E><K><H><I><S><E><L><I><L><V><L><I><S><S><F><N><V><F><F><A><L><L><V><T><L><I><S><Y><L><F><I><L><I><T><I><L><K><R><H><T><G><K><G><Y><Q><K><P><L><S><T><C><G><S><H><L><I><A><I><F><L><F><Y><I><T><V><I><I><M><Y><I><R><P><S><S><S><H><S><M><D><T><D><K><I><A><S><V><F><Y><T><M><I><I><P><M><L><S><P><I><V><Y><T><L><R><N><K><D><V><K><N><A><F><M><K><V><V><E><K><A><K><Y><S><L><D><S><V><F> | Odorant receptor.<BOP> | Q8NGF7 |
P48728 | GCST_HUMAN | Glycine cleavage system T protein | Homo | <M><Q><R><A><V><S><V><V><A><R><L><G><F><R><L><Q><A><F><P><P><A><L><C><R><P><L><S><C><A><Q><E><V><L><R><R><T><P><L><Y><D><F><H><L><A><H><G><G><K><M><V><A><F><A><G><W><S><L><P><V><Q><Y><R><D><S><H><T><D><S><H><L><H><T><R><Q><H><C><S><L><F><D><V><S><H><M><L><Q><T><K><I><L><G><S><D><R><V><K><L><M><E><S><L><V><V><G><D><I><A><E><L><R><P><N><Q><G><T><L><S><L><F><T><N><E><A><G><G><I><L><D><D><L><I><V><T><N><T><S><E><G><H><L><Y><V><V><S><N><A><G><C><W><E><K><D><L><A><L><M><Q><D><K><V><R><E><L><Q><N><Q><G><R><D><V><G><L><E><V><L><D><N><A><L><L><A><L><Q><G><P><T><A><A><Q><V><L><Q><A><G><V><A><D><D><L><R><K><L><P><F><M><T><S><A><V><M><E><V><F><G><V><S><G><C><R><V><T><R><C><G><Y><T><G><E><D><G><V><E><I><S><V><P><V><A><G><A><V><H><L><A><T><A><I><L><K><N><P><E><V><K><L><A><G><L><A><A><R><D><S><L><R><L><E><A><G><L><C><L><Y><G><N><D><I><D><E><H><T><T><P><V><E><G><S><L><S><W><T><L><G><K><R><R><R><A><A><M><D><F><P><G><A><K><V><I><V><P><Q><L><K><G><R><V><Q><R><R><R><V><G><L><M><C><E><G><A><P><M><R><A><H><S><P><I><L><N><M><E><G><T><K><I><G><T><V><T><S><G><C><P><S><P><S><L><K><K><N><V><A><M><G><Y><V><P><C><E><Y><S><R><P><G><T><M><L><L><V><E><V><R><R><K><Q><Q><M><A><V><V><S><K><M><P><F><V><P><T><N><Y><Y><T><L><K> | The glycine cleavage system catalyzes the degradation of glycine.<BOP> | P48728 |
P19440 | GGT1_HUMAN | Glutathione hydrolase 1 light chain | Homo | <M><K><K><K><L><V><V><L><G><L><L><A><V><V><L><V><L><V><I><V><G><L><C><L><W><L><P><S><A><S><K><E><P><D><N><H><V><Y><T><R><A><A><V><A><A><D><A><K><Q><C><S><K><I><G><R><D><A><L><R><D><G><G><S><A><V><D><A><A><I><A><A><L><L><C><V><G><L><M><N><A><H><S><M><G><I><G><G><G><L><F><L><T><I><Y><N><S><T><T><R><K><A><E><V><I><N><A><R><E><V><A><P><R><L><A><F><A><T><M><F><N><S><S><E><Q><S><Q><K><G><G><L><S><V><A><V><P><G><E><I><R><G><Y><E><L><A><H><Q><R><H><G><R><L><P><W><A><R><L><F><Q><P><S><I><Q><L><A><R><Q><G><F><P><V><G><K><G><L><A><A><A><L><E><N><K><R><T><V><I><E><Q><Q><P><V><L><C><E><V><F><C><R><D><R><K><V><L><R><E><G><E><R><L><T><L><P><Q><L><A><D><T><Y><E><T><L><A><I><E><G><A><Q><A><F><Y><N><G><S><L><T><A><Q><I><V><K><D><I><Q><A><A><G><G><I><V><T><A><E><D><L><N><N><Y><R><A><E><L><I><E><H><P><L><N><I><S><L><G><D><V><V><L><Y><M><P><S><A><P><L><S><G><P><V><L><A><L><I><L><N><I><L><K><G><Y><N><F><S><R><E><S><V><E><S><P><E><Q><K><G><L><T><Y><H><R><I><V><E><A><F><R><F><A><Y><A><K><R><T><L><L><G><D><P><K><F><V><D><V><T><E><V><V><R><N><M><T><S><E><F><F><A><A><Q><L><R><A><Q><I><S><D><D><T><T><H><P><I><S><Y><Y><K><P><E><F><Y><T><P><D><D><G><G><T><A><H><L><S><V><V><A><E><D><G><S><A><V><S><A><T><S><T><I><N><L><Y><F><G><S><K><V><R><S><P><V><S><G><I><L><F><N><N><E><M><D><D><F><S><S><P><S><I><T><N><E><F><G><V><P><P><S><P><A><N><F><I><Q><P><G><K><Q><P><L><S><S><M><C><P><T><I><M><V><G><Q><D><G><Q><V><R><M><V><V><G><A><A><G><G><T><Q><I><T><T><A><T><A><L><A><I><I><Y><N><L><W><F><G><Y><D><V><K><R><A><V><E><E><P><R><L><H><N><Q><L><L><P><N><V><T><T><V><E><R><N><I><D><Q><A><V><T><A><A><L><E><T><R><H><H><H><T><Q><I><A><S><T><F><I><A><V><V><Q><A><I><V><R><T><A><G><G><W><A><A><A><S><D><S><R><K><G><G><E><P><A><G><Y> | Seems to be inactive.<BOP> | P19440 |
O43365 | HXA3_HUMAN | Homeobox protein Hox-1E | Homo | <M><Q><K><A><T><Y><Y><D><S><S><A><I><Y><G><G><Y><P><Y><Q><A><A><N><G><F><A><Y><N><A><N><Q><Q><P><Y><P><A><S><A><A><L><G><A><D><G><E><Y><H><R><P><A><C><S><L><Q><S><P><S><S><A><G><G><H><P><K><A><H><E><L><S><E><A><C><L><R><T><L><S><A><P><P><S><Q><P><P><S><L><G><E><P><P><L><H><P><P><P><P><Q><A><A><P><P><A><P><Q><P><P><Q><P><A><P><Q><P><P><A><P><T><P><A><A><P><P><P><P><S><S><A><S><P><P><Q><N><A><S><N><N><P><T><P><A><N><A><A><K><S><P><L><L><N><S><P><T><V><A><K><Q><I><F><P><W><M><K><E><S><R><Q><N><T><K><Q><K><T><S><S><S><S><S><G><E><S><C><A><G><D><K><S><P><P><G><Q><A><S><S><K><R><A><R><T><A><Y><T><S><A><Q><L><V><E><L><E><K><E><F><H><F><N><R><Y><L><C><R><P><R><R><V><E><M><A><N><L><L><N><L><T><E><R><Q><I><K><I><W><F><Q><N><R><R><M><K><Y><K><K><D><Q><K><G><K><G><M><L><T><S><S><G><G><Q><S><P><S><R><S><P><V><P><P><G><A><G><G><Y><L><N><S><M><H><S><L><V><N><S><V><P><Y><E><P><Q><S><P><P><P><F><S><K><P><P><Q><G><T><Y><G><L><P><P><A><S><Y><P><A><S><L><P><S><C><A><P><P><P><P><P><Q><K><R><Y><T><A><A><G><A><G><A><G><G><T><P><D><Y><D><P><H><A><H><G><L><Q><G><N><G><S><Y><G><T><P><H><I><Q><G><S><P><V><F><V><G><G><S><Y><V><E><P><M><S><N><S><G><P><A><L><F><G><L><T><H><L><P><H><A><A><S><G><A><M><D><Y><G><G><A><G><P><L><G><S><G><H><H><H><G><P><G><P><G><E><P><H><P><T><Y><T><D><L><T><G><H><H><P><S><Q><G><R><I><Q><E><A><P><K><L><T><H><L> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | O43365 |
Q96T92 | INSM2_HUMAN | Zinc finger protein IA-6 | Homo | <M><P><R><G><F><L><V><K><R><T><K><R><T><G><G><L><Y><R><V><R><L><A><E><R><V><F><P><L><L><G><P><Q><G><A><P><P><F><L><E><E><A><P><S><A><S><L><P><G><A><E><R><A><T><P><P><T><R><E><E><P><G><K><G><L><T><A><E><A><A><R><E><Q><S><G><S><P><C><R><A><A><G><V><S><P><G><T><G><G><R><E><G><A><E><W><R><A><G><G><R><E><G><P><G><P><S><P><S><P><S><P><S><P><A><K><P><A><G><A><E><L><R><R><A><F><L><E><R><C><L><S><S><P><V><S><A><E><S><F><P><G><G><A><A><A><V><A><A><F><S><C><S><V><A><P><A><A><A><P><T><P><G><E><Q><F><L><L><P><L><R><A><P><F><P><E><P><A><L><Q><P><D><P><A><P><L><S><A><A><L><Q><S><L><K><R><A><A><G><G><E><R><R><G><K><A><P><T><D><C><A><S><G><P><A><A><A><G><I><K><K><P><K><A><M><R><K><L><S><F><A><D><E><V><T><T><S><P><V><L><G><L><K><I><K><E><E><E><P><G><A><P><S><R><G><L><G><G><S><R><T><P><L><G><E><F><I><C><Q><L><C><K><E><Q><Y><A><D><P><F><A><L><A><Q><H><R><C><S><R><I><V><R><V><E><Y><R><C><P><E><C><D><K><V><F><S><C><P><A><N><L><A><S><H><R><R><W><H><K><P><R><P><A><A><A><N><A><A><T><V><S><S><A><D><G><K><P><P><S><S><S><S><S><S><S><R><D><S><G><A><I><A><S><F><L><A><E><G><K><E><N><S><R><I><E><R><T><A><D><Q><H><P><Q><A><R><D><S><S><G><A><D><Q><H><P><D><S><A><P><R><Q><G><L><Q><V><L><T><H><P><E><P><P><L><P><Q><G><P><Y><T><E><G><V><L><G><R><R><V><P><V><P><G><S><T><S><G><G><R><G><S><E><I><F><V><C><P><Y><C><H><K><K><F><R><R><Q><A><Y><L><R><K><H><L><S><T><H><E><A><G><S><A><R><A><L><A><P><G><F><G><S><E><R><G><A><P><L><A><F><A><C><P><L><C><G><A><H><F><P><T><A><D><I><R><E><K><H><R><L><W><H><A><V><R><E><E><L><L><L><P><A><L><A><G><A><P><P><E><T><S><G><P><S><G><P><S><D><G><S><A><Q><Q><I><F><S><C><K><H><C><P><S><T><F><F><S><S><P><G><L><T><R><H><I><N><K><C><H><P><S><E><S><R><Q><V><L><L><L><Q><M><P><L><R><P><G><C> | May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.<BOP> | Q96T92 |
Q5VXH4 | PRAM6_HUMAN | PRAME family member 6 | Homo | <M><S><I><R><T><P><P><R><L><L><E><L><A><G><R><S><L><L><R><D><Q><A><L><A><M><S><T><L><E><E><L><P><T><E><L><F><P><P><L><F><M><E><A><F><S><R><R><R><C><E><A><L><K><L><M><V><Q><A><W><P><F><R><R><L><P><L><R><P><L><I><K><M><P><C><L><E><A><F><Q><A><V><L><D><G><L><D><A><L><L><T><Q><G><V><H><P><R><R><W><K><L><Q><V><L><D><L><Q><D><V><C><E><N><F><W><M><V><W><S><E><A><M><A><R><G><C><F><L><N><A><K><R><N><K><T><P><V><Q><D><C><P><R><M><R><G><Q><Q><P><L><T><V><F><V><E><L><W><L><K><N><R><T><L><D><E><Y><L><T><C><L><L><L><W><V><K><Q><R><K><D><L><L><H><L><C><C><K><K><L><K><I><L><G><M><P><F><R><N><I><R><S><I><L><K><M><V><N><L><D><C><I><Q><E><V><E><V><N><C><K><W><V><L><P><I><L><T><Q><F><T><P><Y><L><G><H><M><R><N><L><Q><K><L><V><L><S><H><M><D><V><S><R><Y><V><S><P><E><Q><K><K><E><I><V><T><Q><F><T><T><Q><F><L><K><L><C><C><L><Q><K><L><S><M><N><S><V><S><F><L><E><G><H><L><D><Q><L><L><S><C><L><K><T><S><L><K><V><L><T><I><T><N><C><V><L><L><E><S><D><L><K><H><L><S><Q><C><P><S><I><S><Q><L><K><T><L><D><L><S><G><I><R><L><T><N><Y><S><L><V><P><L><Q><I><L><L><E><K><V><A><A><T><L><E><Y><L><D><L><D><D><C><G><I><I><D><S><Q><V><N><A><I><L><P><A><L><S><R><C><F><E><L><N><T><F><S><F><C><G><N><P><I><S><M><A><T><L><E><N><L><L><S><H><T><I><I><L><K><N><L><C><V><E><L><Y><P><A><P><R><E><S><Y><D><A><D><G><T><L><C><W><S><R><F><A><Q><I><R><A><E><L><M><K><R><V><R><D><L><R><H><P><K><R><I><L><F><C><T><D><C><C><P><D><C><G><N><R><S><F><Y><D><L><E><A><D><Q><C><C><C> | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation . The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding .<BOP> | Q5VXH4 |
Q9HC24 | LFG4_HUMAN | Z-protein | Homo | <M><A><D><P><D><P><R><Y><P><R><S><S><I><E><D><D><F><N><Y><G><S><S><V><A><S><A><T><V><H><I><R><M><A><F><L><R><K><V><Y><S><I><L><S><L><Q><V><L><L><T><T><V><T><S><T><V><F><L><Y><F><E><S><V><R><T><F><V><H><E><S><P><A><L><I><L><L><F><A><L><G><S><L><G><L><I><F><A><L><I><L><N><R><H><K><Y><P><L><N><L><Y><L><L><F><G><F><T><L><L><E><A><L><T><V><A><V><V><V><T><F><Y><D><V><Y><I><I><L><Q><A><F><I><L><T><T><T><V><F><F><G><L><T><V><Y><T><L><Q><S><K><K><D><F><S><K><F><G><A><G><L><F><A><L><L><W><I><L><C><L><S><G><F><L><K><F><F><F><Y><S><E><I><M><E><L><V><L><A><A><A><G><A><L><L><F><C><G><F><I><I><Y><D><T><H><S><L><M><H><K><L><S><P><E><E><Y><V><L><A><A><I><S><L><Y><L><D><I><I><N><L><F><L><H><L><L><R><F><L><E><A><V><N><K><K> | Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.<BOP> | Q9HC24 |
P09131 | P3_HUMAN | Solute carrier family 10 member 3 | Homo | <M><V><L><M><Q><D><K><G><S><S><Q><Q><W><P><G><L><G><G><E><G><G><G><T><G><P><L><S><M><L><R><A><A><L><L><L><I><S><L><P><W><G><A><Q><G><T><A><S><T><S><L><S><T><A><G><G><H><T><V><P><P><T><G><G><R><Y><L><S><I><G><D><G><S><V><M><E><F><E><F><P><E><D><S><E><G><I><I><V><I><S><S><Q><Y><P><G><Q><A><N><R><T><A><P><G><P><M><L><R><V><T><S><L><D><T><E><V><L><T><I><K><N><V><S><A><I><T><W><G><G><G><G><G><F><V><V><S><I><H><S><G><L><A><G><L><A><P><L><H><I><Q><L><V><D><A><H><E><A><P><P><T><L><I><E><E><R><R><D><F><C><I><K><V><S><P><A><E><D><T><P><A><T><L><S><A><D><L><A><H><F><S><E><N><P><I><L><Y><L><L><L><P><L><I><F><V><N><K><C><S><F><G><C><K><V><E><L><E><V><L><K><G><L><M><Q><S><P><Q><P><M><L><L><G><L><L><G><Q><F><L><V><M><P><L><Y><A><F><L><M><A><K><V><F><M><L><P><K><A><L><A><L><G><L><I><I><T><C><S><S><P><G><G><G><G><S><Y><L><F><S><L><L><L><G><G><D><V><T><L><A><I><S><M><T><F><L><S><T><V><A><A><T><G><F><L><P><L><S><S><A><I><Y><S><R><L><L><S><I><H><E><T><L><H><V><P><I><S><K><I><L><G><T><L><L><F><I><A><I><P><I><A><V><G><V><L><I><K><S><K><L><P><K><F><S><Q><L><L><L><Q><V><V><K><P><F><S><F><V><L><L><L><G><G><L><F><L><A><Y><R><M><G><V><F><I><L><A><G><I><R><L><P><I><V><L><V><G><I><T><V><P><L><V><G><L><L><V><G><Y><C><L><A><T><C><L><K><L><P><V><A><Q><R><R><T><V><S><I><E><V><G><V><Q><N><S><L><L><A><L><A><M><L><Q><L><S><L><R><R><L><Q><A><D><Y><A><S><Q><A><P><F><I><V><A><L><S><G><T><S><E><M><L><A><L><V><I><G><H><F><I><Y><S><S><L><F><P><V><P> | The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.<BOP> | P09131 |
P01241 | SOMA_HUMAN | Pituitary growth hormone | Homo | <M><A><T><G><S><R><T><S><L><L><L><A><F><G><L><L><C><L><P><W><L><Q><E><G><S><A><F><P><T><I><P><L><S><R><L><F><D><N><A><M><L><R><A><H><R><L><H><Q><L><A><F><D><T><Y><Q><E><F><E><E><A><Y><I><P><K><E><Q><K><Y><S><F><L><Q><N><P><Q><T><S><L><C><F><S><E><S><I><P><T><P><S><N><R><E><E><T><Q><Q><K><S><N><L><E><L><L><R><I><S><L><L><L><I><Q><S><W><L><E><P><V><Q><F><L><R><S><V><F><A><N><S><L><V><Y><G><A><S><D><S><N><V><Y><D><L><L><K><D><L><E><E><G><I><Q><T><L><M><G><R><L><E><D><G><S><P><R><T><G><Q><I><F><K><Q><T><Y><S><K><F><D><T><N><S><H><N><D><D><A><L><L><K><N><Y><G><L><L><Y><C><F><R><K><D><M><D><K><V><E><T><F><L><R><I><V><Q><C><R><S><V><E><G><S><C><G><F> | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.<BOP> | P01241 |
Q6XQN6 | PNCB_HUMAN | Nicotinate phosphoribosyltransferase domain-containing protein 1 | Homo | <M><A><A><E><Q><D><P><E><A><R><A><A><A><R><P><L><L><T><D><L><Y><Q><A><T><M><A><L><G><Y><W><R><A><G><R><A><R><D><A><A><E><F><E><L><F><F><R><R><C><P><F><G><G><A><F><A><L><A><A><G><L><R><D><C><V><R><F><L><R><A><F><R><L><R><D><A><D><V><Q><F><L><A><S><V><L><P><P><D><T><D><P><A><F><F><E><H><L><R><A><L><D><C><S><E><V><T><V><R><A><L><P><E><G><S><L><A><F><P><G><V><P><L><L><Q><V><S><G><P><L><L><V><V><Q><L><L><E><T><P><L><L><C><L><V><S><Y><A><S><L><V><A><T><N><A><A><R><L><R><L><I><A><G><P><E><K><R><L><L><E><M><G><L><R><R><A><Q><G><P><D><G><G><L><T><A><S><T><Y><S><Y><L><G><G><F><D><S><S><S><N><V><L><A><G><Q><L><R><G><V><P><V><A><G><T><L><A><H><S><F><V><T><S><F><S><G><S><E><V><P><P><D><P><M><L><A><P><A><A><G><E><G><P><G><V><D><L><A><A><K><A><Q><V><W><L><E><Q><V><C><A><H><L><G><L><G><V><Q><E><P><H><P><G><E><R><A><A><F><V><A><Y><A><L><A><F><P><R><A><F><Q><G><L><L><D><T><Y><S><V><W><R><S><G><L><P><N><F><L><A><V><A><L><A><L><G><E><L><G><Y><R><A><V><G><V><R><L><D><S><G><D><L><L><Q><Q><A><Q><E><I><R><K><V><F><R><A><A><A><A><Q><F><Q><V><P><W><L><E><S><V><L><I><V><V><S><N><N><I><D><E><E><A><L><A><R><L><A><Q><E><G><S><E><V><N><V><I><G><I><G><T><S><V><V><T><C><P><Q><Q><P><S><L><G><G><V><Y><K><L><V><A><V><G><G><Q><P><R><M><K><L><T><E><D><P><E><K><Q><T><L><P><G><S><K><A><A><F><R><L><L><G><S><D><G><S><P><L><M><D><M><L><Q><L><A><E><E><P><V><P><Q><A><G><Q><E><L><R><V><W><P><P><G><A><Q><E><P><C><T><V><R><P><A><Q><V><E><P><L><L><R><L><C><L><Q><Q><G><Q><L><C><E><P><L><P><S><L><A><E><S><R><A><L><A><Q><L><S><L><S><R><L><S><P><E><H><R><R><L><R><S><P><A><Q><Y><Q><V><V><L><S><E><R><L><Q><A><L><V><N><S><L><C><A><G><Q><S><P> | Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate . Helps prevent cellular oxidative stress via its role in NAD biosynthesis .<BOP> | Q6XQN6 |
Q9Y5P4 | CERT_HUMAN | StAR-related lipid transfer protein 11 | null | <M><S><D><N><Q><S><W><N><S><S><G><S><E><E><D><P><E><T><E><S><G><P><P><V><E><R><C><G><V><L><S><K><W><T><N><Y><I><H><G><W><Q><D><R><W><V><V><L><K><N><N><A><L><S><Y><Y><K><S><E><D><E><T><E><Y><G><C><R><G><S><I><C><L><S><K><A><V><I><T><P><H><D><F><D><E><C><R><F><D><I><S><V><N><D><S><V><W><Y><L><R><A><Q><D><P><D><H><R><Q><Q><W><I><D><A><I><E><Q><H><K><T><E><S><G><Y><G><S><E><S><S><L><R><R><H><G><S><M><V><S><L><V><S><G><A><S><G><Y><S><A><T><S><T><S><S><F><K><K><G><H><S><L><R><E><K><L><A><E><M><E><T><F><R><D><I><L><C><R><Q><V><D><T><L><Q><K><Y><F><D><A><C><A><D><A><V><S><K><D><E><L><Q><R><D><K><V><V><E><D><D><E><D><D><F><P><T><T><R><S><D><G><D><F><L><H><S><T><N><G><N><K><E><K><L><F><P><H><V><T><P><K><G><I><N><G><I><D><F><K><G><E><A><I><T><F><K><A><T><T><A><G><I><L><A><T><L><S><H><C><I><E><L><M><V><K><R><E><D><S><W><Q><K><R><L><D><K><E><T><E><K><K><R><R><T><E><E><A><Y><K><N><A><M><T><E><L><K><K><K><S><H><F><G><G><P><D><Y><E><E><G><P><N><S><L><I><N><E><E><E><F><F><D><A><V><E><A><A><L><D><R><Q><D><K><I><E><E><Q><S><Q><S><E><K><V><R><L><H><W><P><T><S><L><P><S><G><D><A><F><S><S><V><G><T><H><R><F><V><Q><K><P><Y><S><R><S><S><S><M><S><S><I><D><L><V><S><A><S><D><D><V><H><R><F><S><S><Q><V><E><E><M><V><Q><N><H><M><T><Y><S><L><Q><D><V><G><G><D><A><N><W><Q><L><V><V><E><E><G><E><M><K><V><Y><R><R><E><V><E><E><N><G><I><V><L><D><P><L><K><A><T><H><A><V><K><G><V><T><G><H><E><V><C><N><Y><F><W><N><V><D><V><R><N><D><W><E><T><T><I><E><N><F><H><V><V><E><T><L><A><D><N><A><I><I><I><Y><Q><T><H><K><R><V><W><P><A><S><Q><R><D><V><L><Y><L><S><V><I><R><K><I><P><A><L><T><E><N><D><P><E><T><W><I><V><C><N><F><S><V><D><H><D><S><A><P><L><N><N><R><C><V><R><A><K><I><N><V><A><M><I><C><Q><T><L><V><S><P><P><E><G><N><Q><E><I><S><R><D><N><I><L><C><K><I><T><Y><V><A><N><V><N><P><G><G><W><A><P><A><S><V><L><R><A><V><A><K><R><E><Y><P><K><F><L><K><R><F><T><S><Y><V><Q><E><K><T><A><G><K><P><I><L><F> | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<BOP> | Q9Y5P4 |
Q6UY09 | CEA20_HUMAN | Carcinoembryonic antigen-related cell adhesion molecule 20 | Homo | <M><G><P><A><D><S><W><G><H><H><W><M><G><I><L><L><S><A><S><L><C><T><V><W><S><P><P><A><A><A><Q><L><T><L><N><A><N><P><L><D><A><T><Q><S><E><D><V><V><L><P><V><F><G><T><P><R><T><P><Q><I><H><G><R><S><R><E><L><A><K><P><S><I><A><V><S><P><G><T><A><I><E><Q><K><D><M><V><T><F><Y><C><T><T><K><D><V><N><I><T><I><H><W><V><S><N><N><L><S><I><V><F><H><E><R><M><Q><L><S><K><D><G><K><I><L><T><I><L><I><V><Q><R><E><D><S><G><T><Y><Q><C><E><A><R><D><A><L><L><S><Q><R><S><D><P><I><F><L><D><V><K><Y><G><P><D><P><V><E><I><K><L><E><S><G><V><A><S><G><E><V><V><E><V><M><E><G><S><S><M><T><F><L><A><E><T><K><S><H><P><P><C><A><Y><T><W><F><L><L><D><S><I><L><S><H><T><T><R><T><F><T><I><H><A><V><S><R><E><H><E><G><L><Y><R><C><L><V><S><N><S><A><T><H><L><S><S><L><G><T><L><K><V><R><V><L><E><T><L><T><M><P><Q><V><V><P><S><S><L><N><L><V><E><N><A><R><S><V><D><L><T><C><Q><T><V><N><Q><S><V><N><V><Q><W><F><L><S><G><Q><P><L><L><P><S><E><H><L><Q><L><S><A><D><N><R><T><L><I><I><H><G><L><Q><R><N><D><T><G><P><Y><A><C><E><V><W><N><W><G><S><R><A><R><S><E><P><L><E><L><T><I><N><Y><G><P><D><Q><V><H><I><T><R><E><S><A><S><E><M><I><S><T><I><E><A><E><L><N><S><S><L><T><L><Q><C><W><A><E><S><K><P><G><A><E><Y><R><W><T><L><E><H><S><T><G><E><H><L><G><E><Q><L><I><I><R><A><L><T><W><E><H><D><G><I><Y><N><C><T><A><S><N><S><L><T><G><L><A><R><S><T><S><V><L><V><K><V><V><G><P><Q><S><S><S><L><S><S><G><A><I><A><G><I><V><I><G><I><L><A><V><I><A><V><A><S><E><L><G><Y><F><L><C><I><R><N><A><R><R><P><S><R><K><T><T><E><D><P><S><H><E><T><S><Q><P><I><P><K><E><E><H><P><T><E><P><S><S><E><S><L><S><P><E><Y><R><N><I><S><Q><L><Q><G><R><I><R><V><E><L><M><Q><P><P><D><L><P><E><E><T><Y><E><T><K><L><P><S><A><S><R><R><G><N><S><F><S><P><W><K><P><P><P><K><P><L><M><P><P><L><R><L><V><S><T><V><P><K><N><M><E><S><I><Y><E><E><L><V><N><P><E><P><N><T><Y><I><Q><I><N><P><S><V> | Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.<BOP> | Q6UY09 |
P25325 | THTM_HUMAN | 3-mercaptopyruvate sulfurtransferase | Homo | <M><A><S><P><Q><L><C><R><A><L><V><S><A><Q><W><V><A><E><A><L><R><A><P><R><A><G><Q><P><L><Q><L><L><D><A><S><W><Y><L><P><K><L><G><R><D><A><R><R><E><F><E><E><R><H><I><P><G><A><A><F><F><D><I><D><Q><C><S><D><R><T><S><P><Y><D><H><M><L><P><G><A><E><H><F><A><E><Y><A><G><R><L><G><V><G><A><A><T><H><V><V><I><Y><D><A><S><D><Q><G><L><Y><S><A><P><R><V><W><W><M><F><R><A><F><G><H><H><A><V><S><L><L><D><G><G><L><R><H><W><L><R><Q><N><L><P><L><S><S><G><K><S><Q><P><A><P><A><E><F><R><A><Q><L><D><P><A><F><I><K><T><Y><E><D><I><K><E><N><L><E><S><R><R><F><Q><V><V><D><S><R><A><T><G><R><F><R><G><T><E><P><E><P><R><D><G><I><E><P><G><H><I><P><G><T><V><N><I><P><F><T><D><F><L><S><Q><E><G><L><E><K><S><P><E><E><I><R><H><L><F><Q><E><K><K><V><D><L><S><K><P><L><V><A><T><C><G><S><G><V><T><A><C><H><V><A><L><G><A><Y><L><C><G><K><P><D><V><P><I><Y><D><G><S><W><V><E><W><Y><M><R><A><R><P><E><D><V><I><S><E><G><R><G><K><T><H> | Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.<BOP> | P25325 |
P56270 | MAZ_HUMAN | Zinc finger protein 801 | Homo | <M><F><P><V><F><P><C><T><L><L><A><P><P><F><P><V><L><G><L><D><S><R><G><V><G><G><L><M><N><S><F><P><P><P><Q><G><H><A><Q><N><P><L><Q><V><G><A><E><L><Q><S><R><F><F><A><S><Q><G><C><A><Q><S><P><F><Q><A><A><P><A><P><P><P><T><P><Q><A><P><A><A><E><P><L><Q><V><D><L><L><P><V><L><A><A><A><Q><E><S><A><A><A><A><A><A><A><A><A><A><A><A><A><V><A><A><A><P><P><A><P><A><A><A><S><T><V><D><T><A><A><L><K><Q><P><P><A><P><P><P><P><P><P><P><V><S><A><P><A><A><E><A><A><P><P><A><S><A><A><T><I><A><A><A><A><A><T><A><V><V><A><P><T><S><T><V><A><V><A><P><V><A><S><A><L><E><K><K><T><K><S><K><G><P><Y><I><C><A><L><C><A><K><E><F><K><N><G><Y><N><L><R><R><H><E><A><I><H><T><G><A><K><A><G><R><V><P><S><G><A><M><K><M><P><T><M><V><P><L><S><L><L><S><V><P><Q><L><S><G><A><G><G><G><G><G><E><A><G><A><G><G><G><A><A><A><V><A><A><G><G><V><V><T><T><T><A><S><G><K><R><I><R><K><N><H><A><C><E><M><C><G><K><A><F><R><D><V><Y><H><L><N><R><H><K><L><S><H><S><D><E><K><P><Y><Q><C><P><V><C><Q><Q><R><F><K><R><K><D><R><M><S><Y><H><V><R><S><H><D><G><A><V><H><K><P><Y><N><C><S><H><C><G><K><S><F><S><R><P><D><H><L><N><S><H><V><R><Q><V><H><S><T><E><R><P><F><K><C><E><K><C><E><A><A><F><A><T><K><D><R><L><R><A><H><T><V><R><H><E><E><K><V><P><C><H><V><C><G><K><M><L><S><S><A><Y><I><S><D><H><M><K><V><H><S><Q><G><P><H><H><V><C><E><L><C><N><K><G><T><G><E><V><C><P><M><A><A><A><A><A><A><A><A><A><A><A><A><A><A><V><A><A><P><P><T><A><V><G><S><L><S><G><A><E><G><V><P><V><S><S><Q><P><L><P><S><Q><P><W> | Binds DNA and functions as a transcriptional activator.<BOP> | P56270 |
A6NK89 | RASFA_HUMAN | Ras association domain-containing protein 10 | Homo | <M><D><P><S><E><K><K><I><S><V><W><I><C><Q><E><E><K><L><V><S><G><L><S><R><R><T><T><C><S><D><V><V><R><V><L><L><E><D><G><C><R><R><R><R><R><Q><R><R><S><R><R><L><G><S><A><G><D><P><H><G><P><G><E><L><P><E><P><P><N><E><D><D><E><D><D><D><E><A><L><P><Q><G><M><L><C><G><P><P><Q><C><Y><C><I><V><E><K><W><R><G><F><E><R><I><L><P><N><K><T><R><I><L><R><L><W><A><A><W><G><E><E><Q><E><N><V><R><F><V><L><V><R><S><E><A><S><L><P><N><A><G><P><R><S><A><E><A><R><V><V><L><S><R><E><R><P><C><P><A><R><G><A><P><A><R><P><S><L><A><M><T><Q><E><K><Q><R><R><V><V><R><K><A><F><R><K><L><A><K><L><N><R><R><R><Q><Q><Q><T><P><S><S><C><S><S><T><S><S><S><T><A><S><S><C><S><S><S><P><R><T><H><E><S><A><S><V><E><R><M><E><T><L><V><H><L><V><L><S><Q><D><H><T><I><R><Q><Q><V><Q><R><L><H><E><L><D><R><E><I><D><H><Y><E><A><K><V><H><L><D><R><M><R><R><H><G><V><N><Y><V><Q><D><T><Y><L><V><G><A><G><I><E><L><D><G><S><R><P><G><E><E><P><E><E><V><A><A><E><A><E><E><A><A><A><A><P><P><L><A><G><E><A><Q><A><A><A><L><E><E><L><A><R><R><C><D><D><L><L><R><L><Q><E><Q><R><V><Q><Q><E><E><L><L><E><R><L><S><A><E><I><Q><E><E><L><N><Q><R><W><M><R><R><R><Q><E><E><L><A><A><R><E><E><P><L><E><P><D><G><G><P><D><G><E><L><L><L><E><Q><E><R><V><R><T><Q><L><S><T><S><L><Y><I><G><L><R><L><N><T><D><L><E><A><V><K><S><D><L><D><Y><S><Q><Q><Q><W><D><S><K><K><R><E><L><Q><G><L><L><Q><T><L><H><T><L><E><L><T><V><A><P><D><G><A><P><G><S><G><S><P><S><R><E><P><G><P><Q><A><C><A><D><M><W><V><D><Q><A><R><G><L><A><K><S><G><P><G><N><D><E><D><S><D><T><G><L><S><S><M><H><S><Q><D><S><D><S><L><P><M><C><E><S><L><V> | Plays an important role in regulating embryonic neurogenesis.<BOP> | A6NK89 |
Q15024 | EXOS7_HUMAN | p8 | Homo | <M><A><S><V><T><L><S><E><A><E><K><V><Y><I><V><H><G><V><Q><E><D><L><R><V><D><G><R><G><C><E><D><Y><R><C><V><E><V><E><T><D><V><V><S><N><T><S><G><S><A><R><V><K><L><G><H><T><D><I><L><V><G><V><K><A><E><M><G><T><P><K><L><E><K><P><N><E><G><Y><L><E><F><F><V><D><C><S><A><S><A><T><P><E><F><E><G><R><G><G><D><D><L><G><T><E><I><A><N><T><L><Y><R><I><F><N><N><K><S><S><V><D><L><K><T><L><C><I><S><P><R><E><H><C><W><V><L><Y><V><D><V><L><L><L><E><C><G><G><N><L><F><D><A><I><S><I><A><V><K><A><A><L><F><N><T><R><I><P><R><V><R><V><L><E><D><E><E><G><S><K><D><I><E><L><S><D><D><P><Y><D><C><I><R><L><S><V><E><N><V><P><C><I><V><T><L><C><K><I><G><Y><R><H><V><V><D><A><T><L><Q><E><E><A><C><S><L><A><S><L><L><V><S><V><T><S><K><G><V><V><T><C><M><R><K><V><G><K><G><S><L><D><P><E><S><I><F><E><M><M><E><T><G><K><R><V><G><K><V><L><H><A><S><L><Q><S><V><V><H><K><E><E><S><L><G><P><K><R><Q><K><V><G><F><L><G> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q15024 |
Q8N8N0 | RN152_HUMAN | RING-type E3 ubiquitin transferase RNF152 | Homo | <M><E><T><L><S><Q><D><S><L><L><E><C><Q><I><C><F><N><Y><Y><S><P><R><R><R><P><K><L><L><D><C><K><H><T><C><C><S><V><C><L><Q><Q><M><R><T><S><Q><K><D><V><R><C><P><W><C><R><G><V><T><K><L><P><P><G><F><S><V><S><Q><L><P><D><D><P><E><V><L><A><V><I><A><I><P><H><T><S><E><H><T><P><V><F><I><K><L><P><S><N><G><C><Y><M><L><P><L><P><I><S><K><E><R><A><L><L><P><G><D><M><G><C><R><L><L><P><G><S><Q><Q><K><S><V><T><V><V><T><I><P><A><E><Q><Q><P><L><Q><G><G><A><P><Q><E><A><V><E><E><E><Q><D><R><R><G><V><V><K><S><S><T><W><S><G><V><C><T><V><I><L><V><A><C><V><L><V><F><L><L><G><I><V><L><H><N><M><S><C><I><S><K><R><F><T><V><I><S><C><G> | E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability . Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed .<BOP> | Q8N8N0 |
P51813 | BMX_HUMAN | NTK38 | Homo | <M><D><T><K><S><I><L><E><E><L><L><L><K><R><S><Q><Q><K><K><K><M><S><P><N><N><Y><K><E><R><L><F><V><L><T><K><T><N><L><S><Y><Y><E><Y><D><K><M><K><R><G><S><R><K><G><S><I><E><I><K><K><I><R><C><V><E><K><V><N><L><E><E><Q><T><P><V><E><R><Q><Y><P><F><Q><I><V><Y><K><D><G><L><L><Y><V><Y><A><S><N><E><E><S><R><S><Q><W><L><K><A><L><Q><K><E><I><R><G><N><P><H><L><L><V><K><Y><H><S><G><F><F><V><D><G><K><F><L><C><C><Q><Q><S><C><K><A><A><P><G><C><T><L><W><E><A><Y><A><N><L><H><T><A><V><N><E><E><K><H><R><V><P><T><F><P><D><R><V><L><K><I><P><R><A><V><P><V><L><K><M><D><A><P><S><S><S><T><T><L><A><Q><Y><D><N><E><S><K><K><N><Y><G><S><Q><P><P><S><S><S><T><S><L><A><Q><Y><D><S><N><S><K><K><I><Y><G><S><Q><P><N><F><N><M><Q><Y><I><P><R><E><D><F><P><D><W><W><Q><V><R><K><L><K><S><S><S><S><S><E><D><V><A><S><S><N><Q><K><E><R><N><V><N><H><T><T><S><K><I><S><W><E><F><P><E><S><S><S><S><E><E><E><E><N><L><D><D><Y><D><W><F><A><G><N><I><S><R><S><Q><S><E><Q><L><L><R><Q><K><G><K><E><G><A><F><M><V><R><N><S><S><Q><V><G><M><Y><T><V><S><L><F><S><K><A><V><N><D><K><K><G><T><V><K><H><Y><H><V><H><T><N><A><E><N><K><L><Y><L><A><E><N><Y><C><F><D><S><I><P><K><L><I><H><Y><H><Q><H><N><S><A><G><M><I><T><R><L><R><H><P><V><S><T><K><A><N><K><V><P><D><S><V><S><L><G><N><G><I><W><E><L><K><R><E><E><I><T><L><L><K><E><L><G><S><G><Q><F><G><V><V><Q><L><G><K><W><K><G><Q><Y><D><V><A><V><K><M><I><K><E><G><S><M><S><E><D><E><F><F><Q><E><A><Q><T><M><M><K><L><S><H><P><K><L><V><K><F><Y><G><V><C><S><K><E><Y><P><I><Y><I><V><T><E><Y><I><S><N><G><C><L><L><N><Y><L><R><S><H><G><K><G><L><E><P><S><Q><L><L><E><M><C><Y><D><V><C><E><G><M><A><F><L><E><S><H><Q><F><I><H><R><D><L><A><A><R><N><C><L><V><D><R><D><L><C><V><K><V><S><D><F><G><M><T><R><Y><V><L><D><D><Q><Y><V><S><S><V><G><T><K><F><P><V><K><W><S><A><P><E><V><F><H><Y><F><K><Y><S><S><K><S><D><V><W><A><F><G><I><L><M><W><E><V><F><S><L><G><K><Q><P><Y><D><L><Y><D><N><S><Q><V><V><L><K><V><S><Q><G><H><R><L><Y><R><P><H><L><A><S><D><T><I><Y><Q><I><M><Y><S><C><W><H><E><L><P><E><K><R><P><T><F><Q><Q><L><L><S><S><I><E><P><L><R><E><K><D><K><H> | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal | P51813 |
P0CG22 | DR4L1_HUMAN | Short chain dehydrogenase/reductase family 25C member 4 | Homo | <M><H><K><A><R><L><R><G><H><C><A><R><A><G><K><S><V><R><L><A><S><S><G><M><T><R><R><D><P><L><T><N><K><V><A><L><V><T><A><S><T><D><W><I><G><F><A><V><A><Q><R><L><A><Q><D><G><A><H><V><V><V><S><R><R><K><Q><Q><N><V><D><Q><A><V><A><T><L><Q><G><E><G><L><S><M><T><G><T><V><C><H><V><G><K><M><K><D><W><E><R><L><V><A><T><A><M><K><L><H><G><V><I><D><I><L><S><L><S><I><T><N><S><K><R><G><L><F><W><F><T><L><L><Q><T><A><E><E><A><W><D><R><N><L><D><I><N><G><K><A><L><A><L><M><I><K><A><V><V><P><E><M><E><K><R><G><G><G><S><V><G><F><L><A><S><V><A><A><F><R><P><L><P><G><F><S><P><Y><N><V><S><K><T><A><L><L><G><L><N><K><T><L><A><I><E><L><A><P><R><N><I><R><V><N><C><L><A><P><G><L><I><K><T><S><F><S><R><M><L><W><M><D><K><E><K><E><E><S><M><K><E><T><L><R><I><R><R><L><G><E><P><E><D><S><L><G><I><V><S><F><L><C><S><E><D><A><S><Y><L><T><G><E><T><V><M><V><G><G><G><T><P><S><R><L> | Putative oxidoreductase.<BOP> | P0CG22 |
A3KFT3 | OR2M5_HUMAN | Olfactory receptor 2M5 | Homo | <M><A><W><E><N><Q><T><F><N><S><D><F><I><L><L><G><I><F><N><H><S><P><T><H><T><F><L><F><F><L><V><L><A><I><F><S><V><A><F><M><G><N><S><V><M><V><L><L><I><Y><L><D><T><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><F><L><M><D><L><M><L><I><C><S><T><V><P><K><M><A><F><N><Y><L><S><G><S><K><S><I><S><M><A><G><C><A><T><Q><I><F><F><Y><V><S><L><L><G><S><E><C><F><L><L><A><V><M><S><Y><D><R><Y><I><A><I><C><H><P><L><R><Y><T><N><L><M><R><P><K><I><C><G><L><M><T><A><F><S><W><I><L><G><S><M><D><A><I><I><D><A><V><A><T><F><S><F><S><Y><C><G><S><R><E><I><A><H><F><F><C><D><F><P><S><L><L><I><L><S><C><N><D><T><S><I><F><E><K><V><L><F><I><C><C><I><V><M><I><V><F><P><V><A><I><I><I><A><S><Y><A><R><V><I><L><A><V><I><H><M><G><S><G><E><G><R><R><K><A><F><T><T><C><S><S><H><L><M><V><V><G><M><Y><Y><G><A><G><L><F><M><Y><I><R><P><T><S><D><R><S><P><M><Q><D><K><L><V><S><V><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><T><R><A><L><R><K><V><L><G><K><G><K><C><G><E> | Odorant receptor.<BOP> | A3KFT3 |
Q8WWQ2 | HPSE2_HUMAN | Inactive heparanase-2 | Homo | <M><R><V><L><C><A><F><P><E><A><M><P><S><S><N><S><R><P><P><A><C><L><A><P><G><A><L><Y><L><A><L><L><L><H><L><S><L><S><S><Q><A><G><D><R><R><P><L><P><V><D><R><A><A><G><L><K><E><K><T><L><I><L><L><D><V><S><T><K><N><P><V><R><T><V><N><E><N><F><L><S><L><Q><L><D><P><S><I><I><H><D><G><W><L><D><F><L><S><S><K><R><L><V><T><L><A><R><G><L><S><P><A><F><L><R><F><G><G><K><R><T><D><F><L><Q><F><Q><N><L><R><N><P><A><K><S><R><G><G><P><G><P><D><Y><Y><L><K><N><Y><E><D><D><I><V><R><S><D><V><A><L><D><K><Q><K><G><C><K><I><A><Q><H><P><D><V><M><L><E><L><Q><R><E><K><A><A><Q><M><H><L><V><L><L><K><E><Q><F><S><N><T><Y><S><N><L><I><L><T><A><R><S><L><D><K><L><Y><N><F><A><D><C><S><G><L><H><L><I><F><A><L><N><A><L><R><R><N><P><N><N><S><W><N><S><S><S><A><L><S><L><L><K><Y><S><A><S><K><K><Y><N><I><S><W><E><L><G><N><E><P><N><N><Y><R><T><M><H><G><R><A><V><N><G><S><Q><L><G><K><D><Y><I><Q><L><K><S><L><L><Q><P><I><R><I><Y><S><R><A><S><L><Y><G><P><N><I><G><R><P><R><K><N><V><I><A><L><L><D><G><F><M><K><V><A><G><S><T><V><D><A><V><T><W><Q><H><C><Y><I><D><G><R><V><V><K><V><M><D><F><L><K><T><R><L><L><D><T><L><S><D><Q><I><R><K><I><Q><K><V><V><N><T><Y><T><P><G><K><K><I><W><L><E><G><V><V><T><T><S><A><G><G><T><N><N><L><S><D><S><Y><A><A><G><F><L><W><L><N><T><L><G><M><L><A><N><Q><G><I><D><V><V><I><R><H><S><F><F><D><H><G><Y><N><H><L><V><D><Q><N><F><N><P><L><P><D><Y><W><L><S><L><L><Y><K><R><L><I><G><P><K><V><L><A><V><H><V><A><G><L><Q><R><K><P><R><P><G><R><V><I><R><D><K><L><R><I><Y><A><H><C><T><N><H><H><N><H><N><Y><V><R><G><S><I><T><L><F><I><I><N><L><H><R><S><R><K><K><I><K><L><A><G><T><L><R><D><K><L><V><H><Q><Y><L><L><Q><P><Y><G><Q><E><G><L><K><S><K><S><V><Q><L><N><G><Q><P><L><V><M><V><D><D><G><T><L><P><E><L><K><P><R><P><L><R><A><G><R><T><L><V><I><P><P><V><T><M><G><F><Y><V><V><K><N><V><N><A><L><A><C><R><Y><R> | Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).<BOP> | Q8WWQ2 |
P60329 | KR124_HUMAN | Keratin-associated protein 12.4 | Homo | <M><C><H><T><S><H><S><S><G><C><P><M><A><C><P><G><S><P><C><C><V><P><S><T><C><Y><P><P><E><G><Y><G><T><S><C><C><C><S><A><P><C><V><A><L><L><C><R><P><L><C><G><V><S><T><C><C><Q><P><A><C><C><V><P><S><P><C><Q><V><A><C><C><V><P><V><S><C><K><P><V><L><C><V><A><S><F><C><P><T><S><G><C><C><Q><P><F><C><P><T><L><V><Y><R><P><V><T><W><S><T><P><T><G><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | P60329 |
Q9P0P0 | RN181_HUMAN | RING finger protein 181 | Homo | <M><A><S><Y><F><D><E><H><D><C><E><P><S><D><P><E><Q><E><T><R><T><N><M><L><L><E><L><A><R><S><L><F><N><R><M><D><F><E><D><L><G><L><V><V><D><W><D><H><H><L><P><P><P><A><A><K><T><V><V><E><N><L><P><R><T><V><I><R><G><S><Q><A><E><L><K><C><P><V><C><L><L><E><F><E><E><E><E><T><A><I><E><M><P><C><H><H><L><F><H><S><S><C><I><L><P><W><L><S><K><T><N><S><C><P><L><C><R><Y><E><L><P><T><D><D><D><T><Y><E><E><H><R><R><D><K><A><R><K><Q><Q><Q><Q><H><R><L><E><N><L><H><G><A><M><Y><T> | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1 .<BOP> | Q9P0P0 |
Q8TDV5 | GP119_HUMAN | G-protein coupled receptor 119 | Homo | <M><E><S><S><F><S><F><G><V><I><L><A><V><L><A><S><L><I><I><A><T><N><T><L><V><A><V><A><V><L><L><L><I><H><K><N><D><G><V><S><L><C><F><T><L><N><L><A><V><A><D><T><L><I><G><V><A><I><S><G><L><L><T><D><Q><L><S><S><P><S><R><P><T><Q><K><T><L><C><S><L><R><M><A><F><V><T><S><S><A><A><A><S><V><L><T><V><M><L><I><T><F><D><R><Y><L><A><I><K><Q><P><F><R><Y><L><K><I><M><S><G><F><V><A><G><A><C><I><A><G><L><W><L><V><S><Y><L><I><G><F><L><P><L><G><I><P><M><F><Q><Q><T><A><Y><K><G><Q><C><S><F><F><A><V><F><H><P><H><F><V><L><T><L><S><C><V><G><F><F><P><A><M><L><L><F><V><F><F><Y><C><D><M><L><K><I><A><S><M><H><S><Q><Q><I><R><K><M><E><H><A><G><A><M><A><G><G><Y><R><S><P><R><T><P><S><D><F><K><A><L><R><T><V><S><V><L><I><G><S><F><A><L><S><W><T><P><F><L><I><T><G><I><V><Q><V><A><C><Q><E><C><H><L><Y><L><V><L><E><R><Y><L><W><L><L><G><V><G><N><S><L><L><N><P><L><I><Y><A><Y><W><Q><K><E><V><R><L><Q><L><Y><H><M><A><L><G><V><K><K><V><L><T><S><F><L><L><F><L><S><A><R><N><C><G><P><E><R><P><R><E><S><S><C><H><I><V><T><I><S><S><S><E><F><D><G> | Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.<BOP> | Q8TDV5 |
P55795 | HNRH2_HUMAN | Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed | Homo | <M><M><L><S><T><E><G><R><E><G><F><V><V><K><V><R><G><L><P><W><S><C><S><A><D><E><V><M><R><F><F><S><D><C><K><I><Q><N><G><T><S><G><I><R><F><I><Y><T><R><E><G><R><P><S><G><E><A><F><V><E><L><E><S><E><E><E><V><K><L><A><L><K><K><D><R><E><T><M><G><H><R><Y><V><E><V><F><K><S><N><S><V><E><M><D><W><V><L><K><H><T><G><P><N><S><P><D><T><A><N><D><G><F><V><R><L><R><G><L><P><F><G><C><S><K><E><E><I><V><Q><F><F><S><G><L><E><I><V><P><N><G><M><T><L><P><V><D><F><Q><G><R><S><T><G><E><A><F><V><Q><F><A><S><Q><E><I><A><E><K><A><L><K><K><H><K><E><R><I><G><H><R><Y><I><E><I><F><K><S><S><R><A><E><V><R><T><H><Y><D><P><P><R><K><L><M><A><M><Q><R><P><G><P><Y><D><R><P><G><A><G><R><G><Y><N><S><I><G><R><G><A><G><F><E><R><M><R><R><G><A><Y><G><G><G><Y><G><G><Y><D><D><Y><G><G><Y><N><D><G><Y><G><F><G><S><D><R><F><G><R><D><L><N><Y><C><F><S><G><M><S><D><H><R><Y><G><D><G><G><S><S><F><Q><S><T><T><G><H><C><V><H><M><R><G><L><P><Y><R><A><T><E><N><D><I><Y><N><F><F><S><P><L><N><P><M><R><V><H><I><E><I><G><P><D><G><R><V><T><G><E><A><D><V><E><F><A><T><H><E><D><A><V><A><A><M><A><K><D><K><A><N><M><Q><H><R><Y><V><E><L><F><L><N><S><T><A><G><T><S><G><G><A><Y><D><H><S><Y><V><E><L><F><L><N><S><T><A><G><A><S><G><G><A><Y><G><S><Q><M><M><G><G><M><G><L><S><N><Q><S><S><Y><G><G><P><A><S><Q><Q><L><S><G><G><Y><G><G><G><Y><G><G><Q><S><S><M><S><G><Y><D><Q><V><L><Q><E><N><S><S><D><Y><Q><S><N><L><A> | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).<BOP> | P55795 |
O43819 | SCO2_HUMAN | Protein SCO2 homolog, mitochondrial | Homo | <M><L><L><L><T><R><S><P><T><A><W><H><R><L><S><Q><L><K><P><R><V><L><P><G><T><L><G><G><Q><A><L><H><L><R><S><W><L><L><S><R><Q><G><P><A><E><T><G><G><Q><G><Q><P><Q><G><P><G><L><R><T><R><L><L><I><T><G><L><F><G><A><G><L><G><G><A><W><L><A><L><R><A><E><K><E><R><L><Q><Q><Q><K><R><T><E><A><L><R><Q><A><A><V><G><Q><G><D><F><H><L><L><D><H><R><G><R><A><R><C><K><A><D><F><R><G><Q><W><V><L><M><Y><F><G><F><T><H><C><P><D><I><C><P><D><E><L><E><K><L><V><Q><V><V><R><Q><L><E><A><E><P><G><L><P><P><V><Q><P><V><F><I><T><V><D><P><E><R><D><D><V><E><A><M><A><R><Y><V><Q><D><F><H><P><R><L><L><G><L><T><G><S><T><K><Q><V><A><Q><A><S><H><S><Y><R><V><Y><Y><N><A><G><P><K><D><E><D><Q><D><Y><I><V><D><H><S><I><A><I><Y><L><L><N><P><D><G><L><F><T><D><Y><Y><G><R><S><R><S><A><E><Q><I><S><D><S><V><R><R><H><M><A><A><F><R><S><V><L><S> | Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 . Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 .<BOP> | O43819 |
P05026 | AT1B1_HUMAN | Sodium/potassium-dependent ATPase subunit beta-1 | Homo | <M><A><R><G><K><A><K><E><E><G><S><W><K><K><F><I><W><N><S><E><K><K><E><F><L><G><R><T><G><G><S><W><F><K><I><L><L><F><Y><V><I><F><Y><G><C><L><A><G><I><F><I><G><T><I><Q><V><M><L><L><T><I><S><E><F><K><P><T><Y><Q><D><R><V><A><P><P><G><L><T><Q><I><P><Q><I><Q><K><T><E><I><S><F><R><P><N><D><P><K><S><Y><E><A><Y><V><L><N><I><V><R><F><L><E><K><Y><K><D><S><A><Q><R><D><D><M><I><F><E><D><C><G><D><V><P><S><E><P><K><E><R><G><D><F><N><H><E><R><G><E><R><K><V><C><R><F><K><L><E><W><L><G><N><C><S><G><L><N><D><E><T><Y><G><Y><K><E><G><K><P><C><I><I><I><K><L><N><R><V><L><G><F><K><P><K><P><P><K><N><E><S><L><E><T><Y><P><V><M><K><Y><N><P><N><V><L><P><V><Q><C><T><G><K><R><D><E><D><K><D><K><V><G><N><V><E><Y><F><G><L><G><N><S><P><G><F><P><L><Q><Y><Y><P><Y><Y><G><K><L><L><Q><P><K><Y><L><Q><P><L><L><A><V><Q><F><T><N><L><T><M><D><T><E><I><R><I><E><C><K><A><Y><G><E><N><I><G><Y><S><E><K><D><R><F><Q><G><R><F><D><V><K><I><E><V><K><S> | Involved in cell adhesion and establishing epithelial cell polarity.<BOP> | P05026 |
Q8IYS8 | BD1L2_HUMAN | Protein FAM44C | Homo | <M><A><D><G><G><G><G><G><S><G><G><A><G><P><A><S><T><R><A><S><G><G><G><G><P><I><N><P><A><S><L><P><P><G><D><P><Q><L><I><A><I><I><V><G><Q><L><K><S><R><G><L><F><D><S><F><R><R><D><C><K><A><D><V><D><T><K><P><A><Y><Q><N><L><S><Q><K><A><D><N><F><V><S><T><H><L><D><K><Q><E><W><N><P><P><A><N><D><N><Q><L><H><D><G><L><R><Q><S><V><V><Q><S><G><R><S><E><A><G><V><D><R><I><S><S><Q><V><V><D><P><K><L><N><H><I><F><R><P><Q><I><E><Q><I><I><H><E><F><L><V><A><Q><K><E><A><A><V><P><A><L><P><P><E><P><E><G><Q><D><P><P><A><P><S><Q><D><T><S> | May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.<BOP> | Q8IYS8 |
Q8N8M0 | NAT16_HUMAN | Probable N-acetyltransferase 16 | Homo | <M><K><L><E><A><S><C><G><T><A><T><S><E><V><P><K><P><E><K><K><T><A><R><D><A><E><P><S><S><E><T><R><P><Q><E><V><E><A><E><P><R><S><G><S><G><P><E><A><E><A><E><P><L><D><F><V><V><A><T><E><R><E><F><E><E><V><L><A><I><S><G><G><I><Y><G><G><L><D><Y><L><P><S><R><Y><H><S><W><L><R><D><P><D><R><T><V><V><L><A><K><R><N><G><G><V><I><A><L><E><S><V><N><V><I><D><A><G><E><T><V><L><V><E><G><L><R><V><A><P><W><E><R><G><K><G><V><A><G><L><L><Q><R><F><C><S><Q><L><V><K><R><Q><H><P><G><V><K><V><A><R><L><T><R><D><D><Q><L><G><P><R><E><L><K><K><Y><R><L><I><T><K><Q><G><I><L><L><V><R><F><N><A><S><A><L><L><A><G><L><G><A><R><L><A><A><L><R><T><S><G><T><F><S><P><L><P><T><E><A><V><S><E><A><G><G><D><V><A><R><L><L><L><S><P><S><V><Q><R><D><V><L><P><G><G><T><I><I><Q><D><W><Q><P><Y><R><P><S><E><S><N><L><R><L><L><A><A><K><G><L><E><W><R><V><D><S><R><A><R><P><R><V><L><T><L><C><T><R><P><F><P><I><P><H><G><G><D><G><T><W><R><Y><L><N><I><D><A><F><G><S><D><G><A><Q><V><Q><S><Q><L><L><W><H><L><Q><R><Q><A><P><R><L><V><G><L><N><V><M><C><Q><L><F><L><E><P><Q><L><W><S><Q><L><A><D><F><C><Q><V><G><L><G><L><E><L><V><K><G><Y><T><E><Q><Y><L><L><E><A><D><I> | Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.<BOP> | Q8N8M0 |
P20472 | PRVA_HUMAN | Parvalbumin alpha | Homo | <M><S><M><T><D><L><L><N><A><E><D><I><K><K><A><V><G><A><F><S><A><T><D><S><F><D><H><K><K><F><F><Q><M><V><G><L><K><K><K><S><A><D><D><V><K><K><V><F><H><M><L><D><K><D><K><S><G><F><I><E><E><D><E><L><G><F><I><L><K><G><F><S><P><D><A><R><D><L><S><A><K><E><T><K><M><L><M><A><A><G><D><K><D><G><D><G><K><I><G><V><D><E><F><S><T><L><V><A><E><S> | In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.<BOP> | P20472 |
Q96B26 | EXOS8_HUMAN | p9 | Homo | <M><A><A><G><F><K><T><V><E><P><L><E><Y><Y><R><R><F><L><K><E><N><C><R><P><D><G><R><E><L><G><E><F><R><T><T><T><V><N><I><G><S><I><S><T><A><D><G><S><A><L><V><K><L><G><N><T><T><V><I><C><G><V><K><A><E><F><A><A><P><S><T><D><A><P><D><K><G><Y><V><V><P><N><V><D><L><P><P><L><C><S><S><R><F><R><S><G><P><P><G><E><E><A><Q><V><A><S><Q><F><I><A><D><V><I><E><N><S><Q><I><I><Q><K><E><D><L><C><I><S><P><G><K><L><V><W><V><L><Y><C><D><L><I><C><L><D><Y><D><G><N><I><L><D><A><C><T><F><A><L><L><A><A><L><K><N><V><Q><L><P><E><V><T><I><N><E><E><T><A><L><A><E><V><N><L><K><K><K><S><Y><L><N><I><R><T><H><P><V><A><T><S><F><A><V><F><D><D><T><L><L><I><V><D><P><T><G><E><E><E><H><L><A><T><G><T><L><T><I><V><M><D><E><E><G><K><L><C><C><L><H><K><P><G><G><S><G><L><T><G><A><K><L><Q><D><C><M><S><R><A><V><T><R><H><K><E><V><K><K><L><M><D><E><V><I><K><S><M><K><P><K> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q96B26 |
P55773 | CCL23_HUMAN | CCL23(30-99) | Homo | <M><K><V><S><V><A><A><L><S><C><L><M><L><V><T><A><L><G><S><Q><A><R><V><T><K><D><A><E><T><E><F><M><M><S><K><L><P><L><E><N><P><V><L><L><D><R><F><H><A><T><S><A><D><C><C><I><S><Y><T><P><R><S><I><P><C><S><L><L><E><S><Y><F><E><T><N><S><E><C><S><K><P><G><V><I><F><L><T><K><K><G><R><R><F><C><A><N><P><S><D><K><Q><V><Q><V><C><M><R><M><L><K><L><D><T><R><I><K><T><R><K><N> | Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.<BOP> | P55773 |
P41273 | TNFL9_HUMAN | 4-1BB ligand | Homo | <M><E><Y><A><S><D><A><S><L><D><P><E><A><P><W><P><P><A><P><R><A><R><A><C><R><V><L><P><W><A><L><V><A><G><L><L><L><L><L><L><L><A><A><A><C><A><V><F><L><A><C><P><W><A><V><S><G><A><R><A><S><P><G><S><A><A><S><P><R><L><R><E><G><P><E><L><S><P><D><D><P><A><G><L><L><D><L><R><Q><G><M><F><A><Q><L><V><A><Q><N><V><L><L><I><D><G><P><L><S><W><Y><S><D><P><G><L><A><G><V><S><L><T><G><G><L><S><Y><K><E><D><T><K><E><L><V><V><A><K><A><G><V><Y><Y><V><F><F><Q><L><E><L><R><R><V><V><A><G><E><G><S><G><S><V><S><L><A><L><H><L><Q><P><L><R><S><A><A><G><A><A><A><L><A><L><T><V><D><L><P><P><A><S><S><E><A><R><N><S><A><F><G><F><Q><G><R><L><L><H><L><S><A><G><Q><R><L><G><V><H><L><H><T><E><A><R><A><R><H><A><W><Q><L><T><Q><G><A><T><V><L><G><L><F><R><V><T><P><E><I><P><A><G><L><P><S><P><R><S><E> | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.<BOP> | P41273 |
P22888 | LSHR_HUMAN | Luteinizing hormone receptor | Homo | <M><K><Q><R><F><S><A><L><Q><L><L><K><L><L><L><L><L><Q><P><P><L><P><R><A><L><R><E><A><L><C><P><E><P><C><N><C><V><P><D><G><A><L><R><C><P><G><P><T><A><G><L><T><R><L><S><L><A><Y><L><P><V><K><V><I><P><S><Q><A><F><R><G><L><N><E><V><I><K><I><E><I><S><Q><I><D><S><L><E><R><I><E><A><N><A><F><D><N><L><L><N><L><S><E><I><L><I><Q><N><T><K><N><L><R><Y><I><E><P><G><A><F><I><N><L><P><R><L><K><Y><L><S><I><C><N><T><G><I><R><K><F><P><D><V><T><K><V><F><S><S><E><S><N><F><I><L><E><I><C><D><N><L><H><I><T><T><I><P><G><N><A><F><Q><G><M><N><N><E><S><V><T><L><K><L><Y><G><N><G><F><E><E><V><Q><S><H><A><F><N><G><T><T><L><T><S><L><E><L><K><E><N><V><H><L><E><K><M><H><N><G><A><F><R><G><A><T><G><P><K><T><L><D><I><S><S><T><K><L><Q><A><L><P><S><Y><G><L><E><S><I><Q><R><L><I><A><T><S><S><Y><S><L><K><K><L><P><S><R><E><T><F><V><N><L><L><E><A><T><L><T><Y><P><S><H><C><C><A><F><R><N><L><P><T><K><E><Q><N><F><S><H><S><I><S><E><N><F><S><K><Q><C><E><S><T><V><R><K><V><N><N><K><T><L><Y><S><S><M><L><A><E><S><E><L><S><G><W><D><Y><E><Y><G><F><C><L><P><K><T><P><R><C><A><P><E><P><D><A><F><N><P><C><E><D><I><M><G><Y><D><F><L><R><V><L><I><W><L><I><N><I><L><A><I><M><G><N><M><T><V><L><F><V><L><L><T><S><R><Y><K><L><T><V><P><R><F><L><M><C><N><L><S><F><A><D><F><C><M><G><L><Y><L><L><L><I><A><S><V><D><S><Q><T><K><G><Q><Y><Y><N><H><A><I><D><W><Q><T><G><S><G><C><S><T><A><G><F><F><T><V><F><A><S><E><L><S><V><Y><T><L><T><V><I><T><L><E><R><W><H><T><I><T><Y><A><I><H><L><D><Q><K><L><R><L><R><H><A><I><L><I><M><L><G><G><W><L><F><S><S><L><I><A><M><L><P><L><V><G><V><S><N><Y><M><K><V><S><I><C><F><P><M><D><V><E><T><T><L><S><Q><V><Y><I><L><T><I><L><I><L><N><V><V><A><F><F><I><I><C><A><C><Y><I><K><I><Y><F><A><V><R><N><P><E><L><M><A><T><N><K><D><T><K><I><A><K><K><M><A><I><L><I><F><T><D><F><T><C><M><A><P><I><S><F><F><A><I><S><A><A><F><K><V><P><L><I><T><V><T><N><S><K><V><L><L><V><L><F><Y><P><I><N><S><C><A><N><P><F><L><Y><A><I><F><T><K><T><F><Q><R><D><F><F><L><L><L><S><K><F><G><C><C><K><R><R><A><E><L><Y><R><R><K><D><F><S><A><Y><T><S><N><C><K><N><G><F><T><G><S><N><K><P><S><Q><S><T><L><K><L><S><T><L><H><C><Q><G><T><A><L><L><D><K><T><R><Y><T><E><C> | Receptor for lutropin-choriogonadotropic hormone . The activity of this receptor is mediated by G proteins which activate adenylate cyclase .<BOP> | P22888 |
Q8IV31 | TM139_HUMAN | Transmembrane protein 139 | Homo | <M><V><P><M><H><L><L><G><R><L><E><K><P><L><L><L><L><C><C><A><S><F><L><L><G><L><A><L><L><G><I><K><T><D><I><T><P><V><A><Y><F><F><L><T><L><G><G><F><F><L><F><A><Y><L><L><V><R><F><L><E><W><G><L><R><S><Q><L><Q><S><M><Q><T><E><S><P><G><P><S><G><N><A><R><D><N><E><A><F><E><V><P><V><Y><E><E><A><V><V><G><L><E><S><Q><C><R><P><Q><E><L><D><Q><P><P><P><Y><S><T><V><V><I><P><P><A><P><E><E><E><Q><P><S><H><P><E><G><S><R><R><A><K><L><E><Q><R><R><M><A><S><E><G><S><M><A><Q><E><G><S><P><G><R><A><P><I><N><L><R><L><R><G><P><R><A><V><S><T><A><P><D><L><Q><S><L><A><A><V><P><T><L><E><P><L><T><P><P><P><A><Y><D><V><C><F><G><H><P><D><D><D><S><V><F><Y><E><D><N><W><A><P><P> | May be involved in cellular trafficking of proteins such as SLC4A1.<BOP> | Q8IV31 |
Q9NY64 | GTR8_HUMAN | Glucose transporter type X1 | Homo | <M><T><P><E><D><P><E><E><T><Q><P><L><L><G><P><P><G><G><S><A><P><R><G><R><R><V><F><L><A><A><F><A><A><A><L><G><P><L><S><F><G><F><A><L><G><Y><S><S><P><A><I><P><S><L><Q><R><A><A><P><P><A><P><R><L><D><D><A><A><A><S><W><F><G><A><V><V><T><L><G><A><A><A><G><G><V><L><G><G><W><L><V><D><R><A><G><R><K><L><S><L><L><L><C><S><V><P><F><V><A><G><F><A><V><I><T><A><A><Q><D><V><W><M><L><L><G><G><R><L><L><T><G><L><A><C><G><V><A><S><L><V><A><P><V><Y><I><S><E><I><A><Y><P><A><V><R><G><L><L><G><S><C><V><Q><L><M><V><V><V><G><I><L><L><A><Y><L><A><G><W><V><L><E><W><R><W><L><A><V><L><G><C><V><P><P><S><L><M><L><L><L><M><C><F><M><P><E><T><P><R><F><L><L><T><Q><H><R><R><Q><E><A><M><A><A><L><R><F><L><W><G><S><E><Q><G><W><E><D><P><P><I><G><A><E><Q><S><F><H><L><A><L><L><R><Q><P><G><I><Y><K><P><F><I><I><G><V><S><L><M><A><F><Q><Q><L><S><G><V><N><A><V><M><F><Y><A><E><T><I><F><E><E><A><K><F><K><D><S><S><L><A><S><V><V><V><G><V><I><Q><V><L><F><T><A><V><A><A><L><I><M><D><R><A><G><R><R><L><L><L><V><L><S><G><V><V><M><V><F><S><T><S><A><F><G><A><Y><F><K><L><T><Q><G><G><P><G><N><S><S><H><V><A><I><S><A><P><V><S><A><Q><P><V><D><A><S><V><G><L><A><W><L><A><V><G><S><M><C><L><F><I><A><G><F><A><V><G><W><G><P><I><P><W><L><L><M><S><E><I><F><P><L><H><V><K><G><V><A><T><G><I><C><V><L><T><N><W><L><M><A><F><L><V><T><K><E><F><S><S><L><M><E><V><L><R><P><Y><G><A><F><W><L><A><S><A><F><C><I><F><S><V><L><F><T><L><F><C><V><P><E><T><K><G><K><T><L><E><Q><I><T><A><H><F><E><G><R> | Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.<BOP> | Q9NY64 |
Q8N136 | DAW1_HUMAN | WD repeat-containing protein 69 | Homo | <M><K><L><K><S><L><L><L><R><Y><Y><P><P><G><I><M><L><E><Y><E><K><H><G><E><L><K><T><K><S><I><D><L><L><D><L><G><P><S><T><D><V><S><A><L><V><E><E><I><Q><K><A><E><P><L><L><T><A><S><R><T><E><Q><V><K><L><L><I><Q><R><L><Q><E><K><L><G><Q><N><S><N><H><T><F><Y><L><F><K><V><L><K><A><H><I><L><P><L><T><N><V><A><L><N><K><S><G><S><C><F><I><T><G><S><Y><D><R><T><C><K><L><W><D><T><A><S><G><E><E><L><N><T><L><E><G><H><R><N><V><V><Y><A><I><A><F><N><N><P><Y><G><D><K><I><A><T><G><S><F><D><K><T><C><K><L><W><S><V><E><T><G><K><C><Y><H><T><F><R><G><H><T><A><E><I><V><C><L><S><F><N><P><Q><S><T><L><V><A><T><G><S><M><D><T><T><A><K><L><W><D><I><Q><N><G><E><E><V><Y><T><L><R><G><H><S><A><E><I><I><S><L><S><F><N><T><S><G><D><R><I><I><T><G><S><F><D><H><T><V><V><V><W><D><A><D><T><G><R><K><V><N><I><L><I><G><H><C><A><E><I><S><S><A><S><F><N><W><D><C><S><L><I><L><T><G><S><M><D><K><T><C><K><L><W><D><A><T><N><G><K><C><V><A><T><L><T><G><H><D><D><E><I><L><D><S><C><F><D><Y><T><G><K><L><I><A><T><A><S><A><D><G><T><A><R><I><F><S><A><A><T><R><K><C><I><A><K><L><E><G><H><E><G><E><I><S><K><I><S><F><N><P><Q><G><N><H><L><L><T><G><S><S><D><K><T><A><R><I><W><D><A><Q><T><G><Q><C><L><Q><V><L><E><G><H><T><D><E><I><F><S><C><A><F><N><Y><K><G><N><I><V><I><T><G><S><K><D><N><T><C><R><I><W><R> | May play a role in axonemal outer row dynein assembly.<BOP> | Q8N136 |
Q9UK08 | GBG8_HUMAN | Gamma-9 | Homo | <M><S><N><N><M><A><K><I><A><E><A><R><K><T><V><E><Q><L><K><L><E><V><N><I><D><R><M><K><V><S><Q><A><A><A><E><L><L><A><F><C><E><T><H><A><K><D><D><P><L><V><T><P><V><P><A><A><E><N><P><F><R><D><K><R><L><F><C><V><L><L> | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<BOP> | Q9UK08 |
P49411 | EFTU_HUMAN | P43 | Homo | <M><A><A><A><T><L><L><R><A><T><P><H><F><S><G><L><A><A><G><R><T><F><L><L><Q><G><L><L><R><L><L><K><A><P><A><L><P><L><L><C><R><G><L><A><V><E><A><K><K><T><Y><V><R><D><K><P><H><V><N><V><G><T><I><G><H><V><D><H><G><K><T><T><L><T><A><A><I><T><K><I><L><A><E><G><G><G><A><K><F><K><K><Y><E><E><I><D><N><A><P><E><E><R><A><R><G><I><T><I><N><A><A><H><V><E><Y><S><T><A><A><R><H><Y><A><H><T><D><C><P><G><H><A><D><Y><V><K><N><M><I><T><G><T><A><P><L><D><G><C><I><L><V><V><A><A><N><D><G><P><M><P><Q><T><R><E><H><L><L><L><A><R><Q><I><G><V><E><H><V><V><V><Y><V><N><K><A><D><A><V><Q><D><S><E><M><V><E><L><V><E><L><E><I><R><E><L><L><T><E><F><G><Y><K><G><E><E><T><P><V><I><V><G><S><A><L><C><A><L><E><G><R><D><P><E><L><G><L><K><S><V><Q><K><L><L><D><A><V><D><T><Y><I><P><V><P><A><R><D><L><E><K><P><F><L><L><P><V><E><A><V><Y><S><V><P><G><R><G><T><V><V><T><G><T><L><E><R><G><I><L><K><K><G><D><E><C><E><L><L><G><H><S><K><N><I><R><T><V><V><T><G><I><E><M><F><H><K><S><L><E><R><A><E><A><G><D><N><L><G><A><L><V><R><G><L><K><R><E><D><L><R><R><G><L><V><M><V><K><P><G><S><I><K><P><H><Q><K><V><E><A><Q><V><Y><I><L><S><K><E><E><G><G><R><H><K><P><F><V><S><H><F><M><P><V><M><F><S><L><T><W><D><M><A><C><R><I><I><L><P><P><E><K><E><L><A><M><P><G><E><D><L><K><F><N><L><I><L><R><Q><P><M><I><L><E><K><G><Q><R><F><T><L><R><D><G><N><R><T><I><G><T><G><L><V><T><N><T><L><A><M><T><E><E><E><K><N><I><K><W><G> | Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.<BOP> | P49411 |
Q14657 | LAGE3_HUMAN | Protein ITBA2 | Homo | <M><R><D><A><D><A><D><A><G><G><G><A><D><G><G><D><G><R><G><G><H><S><C><R><G><G><V><D><T><A><A><A><P><A><G><G><A><P><P><A><H><A><P><G><P><G><R><D><A><A><S><A><A><R><G><S><R><M><R><P><H><I><F><T><L><S><V><P><F><P><T><P><L><E><A><E><I><A><H><G><S><L><A><P><D><A><E><P><H><Q><R><V><V><G><K><D><L><T><V><S><G><R><I><L><V><V><R><W><K><A><E><D><C><R><L><L><R><I><S><V><I><N><F><L><D><Q><L><S><L><V><V><R><T><M><Q><R><F><G><P><P><V><S><R> | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 . LAGE3 functions as a dimerization module for the complex .<BOP> | Q14657 |
P30281 | CCND3_HUMAN | G1/S-specific cyclin-D3 | Homo | <M><E><L><L><C><C><E><G><T><R><H><A><P><R><A><G><P><D><P><R><L><L><G><D><Q><R><V><L><Q><S><L><L><R><L><E><E><R><Y><V><P><R><A><S><Y><F><Q><C><V><Q><R><E><I><K><P><H><M><R><K><M><L><A><Y><W><M><L><E><V><C><E><E><Q><R><C><E><E><E><V><F><P><L><A><M><N><Y><L><D><R><Y><L><S><C><V><P><T><R><K><A><Q><L><Q><L><L><G><A><V><C><M><L><L><A><S><K><L><R><E><T><T><P><L><T><I><E><K><L><C><I><Y><T><D><H><A><V><S><P><R><Q><L><R><D><W><E><V><L><V><L><G><K><L><K><W><D><L><A><A><V><I><A><H><D><F><L><A><F><I><L><H><R><L><S><L><P><R><D><R><Q><A><L><V><K><K><H><A><Q><T><F><L><A><L><C><A><T><D><Y><T><F><A><M><Y><P><P><S><M><I><A><T><G><S><I><G><A><A><V><Q><G><L><G><A><C><S><M><S><G><D><E><L><T><E><L><L><A><G><I><T><G><T><E><V><D><C><L><R><A><C><Q><E><Q><I><E><A><A><L><R><E><S><L><R><E><A><S><Q><T><S><S><S><P><A><P><K><A><P><R><G><S><S><S><Q><G><P><S><Q><T><S><T><P><T><D><V><T><A><I><H><L> | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase . Hypophosphorylates RB1 in early G(1) phase . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals . Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex . Shows transcriptional coactivator activity with ATF5 independently of CDK4 .<BOP> | P30281 |
Q9ULC8 | ZDHC8_HUMAN | Zinc finger protein 378 | Homo | <M><P><R><S><P><G><T><R><L><K><P><A><K><Y><I><P><V><A><T><A><A><A><L><L><V><G><S><S><T><L><F><F><V><F><T><C><P><W><L><T><R><A><V><S><P><A><V><P><V><Y><N><G><I><I><F><L><F><V><L><A><N><F><S><M><A><T><F><M><D><P><G><V><F><P><R><A><D><E><D><E><D><K><E><D><D><F><R><A><P><L><Y><K><N><V><D><V><R><G><I><Q><V><R><M><K><W><C><A><T><C><H><F><Y><R><P><P><R><C><S><H><C><S><V><C><D><N><C><V><E><D><F><D><H><H><C><P><W><V><N><N><C><I><G><R><R><N><Y><R><Y><F><F><L><F><L><L><S><L><S><A><H><M><V><G><V><V><A><F><G><L><V><Y><V><L><N><H><A><E><G><L><G><A><A><H><T><T><I><T><M><A><V><M><C><V><A><G><L><F><F><I><P><V><I><G><L><T><G><F><H><V><V><L><V><T><R><G><R><T><T><N><E><Q><V><T><G><K><F><R><G><G><V><N><P><F><T><R><G><C><C><G><N><V><E><H><V><L><C><S><P><L><A><P><R><Y><V><V><E><P><P><R><L><P><L><A><V><S><L><K><P><P><F><L><R><P><E><L><L><D><R><A><A><P><L><K><V><K><L><S><D><N><G><L><K><A><G><L><G><R><S><K><S><K><G><S><L><D><R><L><D><E><K><P><L><D><L><G><P><P><L><P><P><K><I><E><A><G><T><F><S><S><D><L><Q><T><P><R><P><G><S><A><E><S><A><L><S><V><Q><R><T><S><P><P><T><P><A><M><Y><K><F><R><P><A><F><P><T><G><P><K><V><P><F><C><G><P><G><E><Q><V><P><G><P><D><S><L><T><L><G><D><D><S><I><R><S><L><D><F><V><S><E><P><S><L><D><L><P><D><Y><G><P><G><G><L><H><A><A><Y><P><P><S><P><P><L><S><A><S><D><A><F><S><G><A><L><R><S><L><S><L><K><A><S><S><R><R><G><G><D><H><V><A><L><Q><P><L><R><S><E><G><G><P><P><T><P><H><R><S><I><F><A><P><H><A><L><P><N><R><N><G><S><L><S><Y><D><S><L><L><N><P><G><S><P><G><G><H><A><C><P><A><H><P><A><V><G><V><A><G><Y><H><S><P><Y><L><H><P><G><A><T><G><D><P><P><R><P><L><P><R><S><F><S><P><V><L><G><P><R><P><R><E><P><S><P><V><R><Y><D><N><L><S><R><T><I><M><A><S><I><Q><E><R><K><D><R><E><E><R><E><R><L><L><R><S><Q><A><D><S><L><F><G><D><S><G><V><Y><D><A><P><S><S><Y><S><L><Q><Q><A><S><V><L><S><E><G><P><R><G><P><A><L><R><Y><G><S><R><D><D><L><V><A><G><P><G><F><G><G><A><R><N><P><A><L><Q><T><S><L><S><S><L><S><S><S><V><S><R><A><P><R><T><S><S><S><S><L><Q><A><D><Q><A><S><S><N><A><P><G><P><R><P><S><S><G><S><H><R><S><P><A><R><Q><G><L><P><S><P><P><G><T><P><H><S><P><S><Y><A><G><P><K><A><V><A><F><I><H><T><D><L><P><E><P><P><P><S><L><T><V><Q><R><D><H><P><Q><L><K><T><P><P><S><K><L><N><G><Q><S><P><G><L><A><R><L><G><P><A><T><G><P><P><G><P><S><A><S><P><T><R><H><T><L><V><K><K><V><S><G><V><G><G><T><T><Y><E><I><S><V> | (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.<BOP> | Q9ULC8 |
Q15828 | CYTM_HUMAN | Cystatin-E | Homo | <M><A><R><S><N><L><P><L><A><L><G><L><A><L><V><A><F><C><L><L><A><L><P><R><D><A><R><A><R><P><Q><E><R><M><V><G><E><L><R><D><L><S><P><D><D><P><Q><V><Q><K><A><A><Q><A><A><V><A><S><Y><N><M><G><S><N><S><I><Y><Y><F><R><D><T><H><I><I><K><A><Q><S><Q><L><V><A><G><I><K><Y><F><L><T><M><E><M><G><S><T><D><C><R><K><T><R><V><T><G><D><H><V><D><L><T><T><C><P><L><A><A><G><A><Q><Q><E><K><L><R><C><D><F><E><V><L><V><V><P><W><Q><N><S><S><Q><L><L><K><H><N><C><V><Q><M> | High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain . Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance .<BOP> | Q15828 |
Q14153 | FA53B_HUMAN | Protein simplet | Homo | <M><V><M><V><L><S><E><S><L><S><T><R><G><A><D><S><I><A><C><G><T><F><S><R><E><L><H><T><P><K><K><M><S><Q><G><P><T><L><F><S><C><G><I><M><E><N><D><R><W><R><D><L><D><R><K><C><P><L><Q><I><D><Q><P><S><T><S><I><W><E><C><L><P><E><K><D><S><S><L><W><H><R><E><A><V><T><A><C><A><V><T><S><L><I><K><D><L><S><I><S><D><H><N><G><N><P><S><A><P><P><S><K><R><Q><C><R><S><L><S><F><S><D><E><M><S><S><C><R><T><S><W><R><P><L><G><S><K><V><W><T><P><V><E><K><R><R><C><Y><S><G><G><S><V><Q><R><Y><S><N><G><F><S><T><M><Q><R><S><S><S><F><S><L><P><S><R><A><N><V><L><S><S><P><C><D><Q><A><G><L><H><H><R><F><G><G><Q><P><C><Q><G><V><P><G><S><A><P><C><G><Q><A><G><D><T><W><S><P><D><L><H><P><V><G><G><G><R><L><D><L><Q><R><S><L><S><C><S><H><E><Q><F><S><F><V><E><Y><C><P><P><S><A><N><S><T><P><A><S><T><P><E><L><A><R><R><S><S><G><L><S><R><S><R><S><Q><P><C><V><L><N><D><K><K><V><G><V><K><R><R><R><P><E><E><V><Q><E><Q><R><P><S><L><D><L><A><K><M><A><Q><N><C><Q><T><F><S><S><L><S><C><L><S><A><G><T><E><D><C><G><P><Q><S><P><F><A><R><H><V><S><N><T><R><A><W><T><A><L><L><S><A><S><G><P><G><G><R><T><P><A><G><T><P><V><P><E><P><L><P><P><S><F><D><D><H><L><A><C><Q><E><D><L><S><C><E><E><S><D><S><C><A><L><D><E><D><C><G><R><R><A><E><P><A><A><A><W><R><D><R><G><A><P><G><N><S><L><C><S><L><D><G><E><L><D><I><E><Q><I><E><K><N> | Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization.<BOP> | Q14153 |
Q13569 | TDG_HUMAN | Thymine-DNA glycosylase | Homo | <M><E><A><E><N><A><G><S><Y><S><L><Q><Q><A><Q><A><F><Y><T><F><P><F><Q><Q><L><M><A><E><A><P><N><M><A><V><V><N><E><Q><Q><M><P><E><E><V><P><A><P><A><P><A><Q><E><P><V><Q><E><A><P><K><G><R><K><R><K><P><R><T><T><E><P><K><Q><P><V><E><P><K><K><P><V><E><S><K><K><S><G><K><S><A><K><S><K><E><K><Q><E><K><I><T><D><T><F><K><V><K><R><K><V><D><R><F><N><G><V><S><E><A><E><L><L><T><K><T><L><P><D><I><L><T><F><N><L><D><I><V><I><I><G><I><N><P><G><L><M><A><A><Y><K><G><H><H><Y><P><G><P><G><N><H><F><W><K><C><L><F><M><S><G><L><S><E><V><Q><L><N><H><M><D><D><H><T><L><P><G><K><Y><G><I><G><F><T><N><M><V><E><R><T><T><P><G><S><K><D><L><S><S><K><E><F><R><E><G><G><R><I><L><V><Q><K><L><Q><K><Y><Q><P><R><I><A><V><F><N><G><K><C><I><Y><E><I><F><S><K><E><V><F><G><V><K><V><K><N><L><E><F><G><L><Q><P><H><K><I><P><D><T><E><T><L><C><Y><V><M><P><S><S><S><A><R><C><A><Q><F><P><R><A><Q><D><K><V><H><Y><Y><I><K><L><K><D><L><R><D><Q><L><K><G><I><E><R><N><M><D><V><Q><E><V><Q><Y><T><F><D><L><Q><L><A><Q><E><D><A><K><K><M><A><V><K><E><E><K><Y><D><P><G><Y><E><A><A><Y><G><G><A><Y><G><E><N><P><C><S><S><E><P><C><G><F><S><S><N><G><L><I><E><S><V><E><L><R><G><E><S><A><F><S><G><I><P><N><G><Q><W><M><T><Q><S><F><T><D><Q><I><P><S><F><S><N><H><C><G><T><Q><E><Q><E><E><E><S><H><A> | DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a | Q13569 |
P51878 | CASP5_HUMAN | Caspase-5 subunit p10 | Homo | <M><A><E><D><S><G><K><K><K><R><R><K><N><F><E><A><M><F><K><G><I><L><Q><S><G><L><D><N><F><V><I><N><H><M><L><K><N><N><V><A><G><Q><T><S><I><Q><T><L><V><P><N><T><D><Q><K><S><T><S><V><K><K><D><N><H><K><K><K><T><V><K><M><L><E><Y><L><G><K><D><V><L><H><G><V><F><N><Y><L><A><K><H><D><V><L><T><L><K><E><E><E><K><K><K><Y><Y><D><T><K><I><E><D><K><A><L><I><L><V><D><S><L><R><K><N><R><V><A><H><Q><M><F><T><Q><T><L><L><N><M><D><Q><K><I><T><S><V><K><P><L><L><Q><I><E><A><G><P><P><E><S><A><E><S><T><N><I><L><K><L><C><P><R><E><E><F><L><R><L><C><K><K><N><H><D><E><I><Y><P><I><K><K><R><E><D><R><R><R><L><A><L><I><I><C><N><T><K><F><D><H><L><P><A><R><N><G><A><H><Y><D><I><V><G><M><K><R><L><L><Q><G><L><G><Y><T><V><V><D><E><K><N><L><T><A><R><D><M><E><S><V><L><R><A><F><A><A><R><P><E><H><K><S><S><D><S><T><F><L><V><L><M><S><H><G><I><L><E><G><I><C><G><T><A><H><K><K><K><K><P><D><V><L><L><Y><D><T><I><F><Q><I><F><N><N><R><N><C><L><S><L><K><D><K><P><K><V><I><I><V><Q><A><C><R><G><E><K><H><G><E><L><W><V><R><D><S><P><A><S><L><A><L><I><S><S><Q><S><S><E><N><L><E><A><D><S><V><C><K><I><H><E><E><K><D><F><I><A><F><C><S><S><T><P><H><N><V><S><W><R><D><R><T><R><G><S><I><F><I><T><E><L><I><T><C><F><Q><K><Y><S><C><C><C><H><L><M><E><I><F><R><K><V><Q><K><S><F><E><V><P><Q><A><K><A><Q><M><P><T><I><E><R><A><T><L><T><R><D><F><Y><L><F><P><G><N> | Thiol protease that acts as a mediator of programmed cell death . Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis . During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation .<BOP> | P51878 |
O94921 | CDK14_HUMAN | Serine/threonine-protein kinase PFTAIRE-1 | Homo | <M><C><D><L><I><E><P><Q><P><A><E><K><I><G><K><M><K><K><L><R><R><T><L><S><E><S><F><S><R><I><A><L><K><K><D><D><T><T><F><D><E><I><C><V><T><K><M><S><T><R><N><C><Q><G><M><D><S><V><I><K><P><L><D><T><I><P><E><D><K><K><V><R><V><Q><R><T><Q><S><T><F><D><P><F><E><K><P><A><N><Q><V><K><R><V><H><S><E><N><N><A><C><I><N><F><K><T><S><S><T><G><K><E><S><P><K><V><R><R><H><S><S><P><S><S><P><T><S><P><K><F><G><K><A><D><S><Y><E><K><L><E><K><L><G><E><G><S><Y><A><T><V><Y><K><G><K><S><K><V><N><G><K><L><V><A><L><K><V><I><R><L><Q><E><E><E><G><T><P><F><T><A><I><R><E><A><S><L><L><K><G><L><K><H><A><N><I><V><L><L><H><D><I><I><H><T><K><E><T><L><T><L><V><F><E><Y><V><H><T><D><L><C><Q><Y><M><D><K><H><P><G><G><L><H><P><D><N><V><K><L><F><L><F><Q><L><L><R><G><L><S><Y><I><H><Q><R><Y><I><L><H><R><D><L><K><P><Q><N><L><L><I><S><D><T><G><E><L><K><L><A><D><F><G><L><A><R><A><K><S><V><P><S><H><T><Y><S><N><E><V><V><T><L><W><Y><R><P><P><D><V><L><L><G><S><T><E><Y><S><T><C><L><D><M><W><G><V><G><C><I><F><V><E><M><I><Q><G><V><A><A><F><P><G><M><K><D><I><Q><D><Q><L><E><R><I><F><L><V><L><G><T><P><N><E><D><T><W><P><G><V><H><S><L><P><H><F><K><P><E><R><F><T><L><Y><S><S><K><N><L><R><Q><A><W><N><K><L><S><Y><V><N><H><A><E><D><L><A><S><K><L><L><Q><C><S><P><K><N><R><L><S><A><Q><A><A><L><S><H><E><Y><F><S><D><L><P><P><R><L><W><E><L><T><D><M><S><S><I><F><T><V><P><N><V><R><L><Q><P><E><A><G><E><S><M><R><A><F><G><K><N><N><S><Y><G><K><S><L><S><N><S><K><H> | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.<BOP> | O94921 |
Q8NGI9 | OR5A2_HUMAN | Olfactory receptor OR11-248 | Homo | <M><A><V><G><R><N><N><T><I><V><T><K><F><I><L><L><G><L><S><D><H><P><Q><M><K><I><F><L><F><M><L><F><L><G><L><Y><L><L><T><L><A><W><N><L><S><L><I><A><L><I><K><M><D><S><H><L><H><M><P><M><Y><F><F><L><S><N><L><S><F><L><D><I><C><Y><V><S><S><T><A><P><K><M><L><S><D><I><I><T><E><Q><K><T><I><S><F><V><G><C><A><T><Q><Y><F><V><F><C><G><M><G><L><T><E><C><F><L><L><A><A><M><A><Y><D><R><Y><A><A><I><C><N><P><L><L><Y><T><V><L><I><S><H><T><L><C><L><K><M><V><V><G><A><Y><V><G><G><F><L><S><S><F><I><E><T><Y><S><V><Y><Q><H><D><F><C><G><P><Y><M><I><N><H><F><F><C><D><L><P><P><V><L><A><L><S><C><S><D><T><F><T><S><E><V><V><T><F><I><V><S><V><V><V><G><I><V><S><V><L><V><V><L><I><S><Y><G><Y><I><V><A><A><V><V><K><I><S><S><A><T><G><R><T><K><A><F><S><T><C><A><S><H><L><T><A><V><T><L><F><Y><G><S><G><F><F><M><Y><M><R><P><S><S><S><Y><S><L><N><R><D><K><V><V><S><I><F><Y><A><L><V><I><P><V><V><N><P><I><I><Y><S><F><R><N><K><E><I><K><N><A><M><R><K><A><M><E><R><D><P><G><I><S><H><G><G><P><F><I><F><M><T><L><G> | Odorant receptor.<BOP> | Q8NGI9 |
Q6UW32 | IGFL1_HUMAN | Insulin growth factor-like family member 1 | Homo | <M><A><P><R><G><C><I><V><A><V><F><A><I><F><C><I><S><R><L><L><C><S><H><G><A><P><V><A><P><M><T><P><Y><L><M><L><C><Q><P><H><K><R><C><G><D><K><F><Y><D><P><L><Q><H><C><C><Y><D><D><A><V><V><P><L><A><R><T><Q><T><C><G><N><C><T><F><R><V><C><F><E><Q><C><C><P><W><T><F><M><V><K><L><I><N><Q><N><C><D><S><A><R><T><S><D><D><R><L><C><R><S><V><S> | Probable ligand of the IGFLR1 cell membrane receptor.<BOP> | Q6UW32 |
Q8IZY5 | BLID_HUMAN | Breast cancer cell protein 2 | Homo | <M><V><T><L><L><P><I><E><G><Q><E><I><H><F><F><E><I><L><E><S><E><C><V><L><Y><T><G><W><I><E><R><A><S><G><S><S><I><Y><P><E><A><K><A><R><L><P><L><E><A><L><L><G><S><N><K><E><P><M><L><P><K><E><T><V><L><S><L><K><R><Y><N><L><G><S><S><A><M><K><R><N><V><P><G><H><V><L><Q><R><P><S><Y><L><T><R><I><Q><V><T><L><L><C><N><S><S><A><E><A><L> | Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.<BOP> | Q8IZY5 |
P31153 | METK2_HUMAN | Methionine adenosyltransferase II | Homo | <M><N><G><Q><L><N><G><F><H><E><A><F><I><E><E><G><T><F><L><F><T><S><E><S><V><G><E><G><H><P><D><K><I><C><D><Q><I><S><D><A><V><L><D><A><H><L><Q><Q><D><P><D><A><K><V><A><C><E><T><V><A><K><T><G><M><I><L><L><A><G><E><I><T><S><R><A><A><V><D><Y><Q><K><V><V><R><E><A><V><K><H><I><G><Y><D><D><S><S><K><G><F><D><Y><K><T><C><N><V><L><V><A><L><E><Q><Q><S><P><D><I><A><Q><G><V><H><L><D><R><N><E><E><D><I><G><A><G><D><Q><G><L><M><F><G><Y><A><T><D><E><T><E><E><C><M><P><L><T><I><V><L><A><H><K><L><N><A><K><L><A><E><L><R><R><N><G><T><L><P><W><L><R><P><D><S><K><T><Q><V><T><V><Q><Y><M><Q><D><R><G><A><V><L><P><I><R><V><H><T><I><V><I><S><V><Q><H><D><E><E><V><C><L><D><E><M><R><D><A><L><K><E><K><V><I><K><A><V><V><P><A><K><Y><L><D><E><D><T><I><Y><H><L><Q><P><S><G><R><F><V><I><G><G><P><Q><G><D><A><G><L><T><G><R><K><I><I><V><D><T><Y><G><G><W><G><A><H><G><G><G><A><F><S><G><K><D><Y><T><K><V><D><R><S><A><A><Y><A><A><R><W><V><A><K><S><L><V><K><G><G><L><C><R><R><V><L><V><Q><V><S><Y><A><I><G><V><S><H><P><L><S><I><S><I><F><H><Y><G><T><S><Q><K><S><E><R><E><L><L><E><I><V><K><K><N><F><D><L><R><P><G><V><I><V><R><D><L><D><L><K><K><P><I><Y><Q><R><T><A><A><Y><G><H><F><G><R><D><S><F><P><W><E><V><P><K><K><L><K><Y> | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.<BOP> | P31153 |
Q9NNX6 | CD209_HUMAN | Dendritic cell-specific ICAM-3-grabbing non-integrin 1 | Homo | <M><S><D><S><K><E><P><R><L><Q><Q><L><G><L><L><E><E><E><Q><L><R><G><L><G><F><R><Q><T><R><G><Y><K><S><L><A><G><C><L><G><H><G><P><L><V><L><Q><L><L><S><F><T><L><L><A><G><L><L><V><Q><V><S><K><V><P><S><S><I><S><Q><E><Q><S><R><Q><D><A><I><Y><Q><N><L><T><Q><L><K><A><A><V><G><E><L><S><E><K><S><K><L><Q><E><I><Y><Q><E><L><T><Q><L><K><A><A><V><G><E><L><P><E><K><S><K><L><Q><E><I><Y><Q><E><L><T><R><L><K><A><A><V><G><E><L><P><E><K><S><K><L><Q><E><I><Y><Q><E><L><T><W><L><K><A><A><V><G><E><L><P><E><K><S><K><M><Q><E><I><Y><Q><E><L><T><R><L><K><A><A><V><G><E><L><P><E><K><S><K><Q><Q><E><I><Y><Q><E><L><T><R><L><K><A><A><V><G><E><L><P><E><K><S><K><Q><Q><E><I><Y><Q><E><L><T><R><L><K><A><A><V><G><E><L><P><E><K><S><K><Q><Q><E><I><Y><Q><E><L><T><Q><L><K><A><A><V><E><R><L><C><H><P><C><P><W><E><W><T><F><F><Q><G><N><C><Y><F><M><S><N><S><Q><R><N><W><H><D><S><I><T><A><C><K><E><V><G><A><Q><L><V><V><I><K><S><A><E><E><Q><N><F><L><Q><L><Q><S><S><R><S><N><R><F><T><W><M><G><L><S><D><L><N><Q><E><G><T><W><Q><W><V><D><G><S><P><L><L><P><S><F><K><Q><Y><W><N><R><G><E><P><N><N><V><G><E><E><D><C><A><E><F><S><G><N><G><W><N><D><D><K><C><N><L><A><K><F><W><I><C><K><K><S><A><A><S><C><S><R><D><E><E><Q><F><L><S><P><A><P><A><T><P><N><P><P><P><A> | (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA . Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule .<BOP> | Q9NNX6 |
P01242 | SOM2_HUMAN | Placenta-specific growth hormone | Homo | <M><A><A><G><S><R><T><S><L><L><L><A><F><G><L><L><C><L><S><W><L><Q><E><G><S><A><F><P><T><I><P><L><S><R><L><F><D><N><A><M><L><R><A><R><R><L><Y><Q><L><A><Y><D><T><Y><Q><E><F><E><E><A><Y><I><L><K><E><Q><K><Y><S><F><L><Q><N><P><Q><T><S><L><C><F><S><E><S><I><P><T><P><S><N><R><V><K><T><Q><Q><K><S><N><L><E><L><L><R><I><S><L><L><L><I><Q><S><W><L><E><P><V><Q><L><L><R><S><V><F><A><N><S><L><V><Y><G><A><S><D><S><N><V><Y><R><H><L><K><D><L><E><E><G><I><Q><T><L><M><W><R><L><E><D><G><S><P><R><T><G><Q><I><F><N><Q><S><Y><S><K><F><D><T><K><S><H><N><D><D><A><L><L><K><N><Y><G><L><L><Y><C><F><R><K><D><M><D><K><V><E><T><F><L><R><I><V><Q><C><R><S><V><E><G><S><C><G><F> | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.<BOP> | P01242 |
O43463 | SUV91_HUMAN | Suppressor of variegation 3-9 homolog 1 | Homo | <M><A><E><N><L><K><G><C><S><V><C><C><K><S><S><W><N><Q><L><Q><D><L><C><R><L><A><K><L><S><C><P><A><L><G><I><S><K><R><N><L><Y><D><F><E><V><E><Y><L><C><D><Y><K><K><I><R><E><Q><E><Y><Y><L><V><K><W><R><G><Y><P><D><S><E><S><T><W><E><P><R><Q><N><L><K><C><V><R><I><L><K><Q><F><H><K><D><L><E><R><E><L><L><R><R><H><H><R><S><K><T><P><R><H><L><D><P><S><L><A><N><Y><L><V><Q><K><A><K><Q><R><R><A><L><R><R><W><E><Q><E><L><N><A><K><R><S><H><L><G><R><I><T><V><E><N><E><V><D><L><D><G><P><P><R><A><F><V><Y><I><N><E><Y><R><V><G><E><G><I><T><L><N><Q><V><A><V><G><C><E><C><Q><D><C><L><W><A><P><T><G><G><C><C><P><G><A><S><L><H><K><F><A><Y><N><D><Q><G><Q><V><R><L><R><A><G><L><P><I><Y><E><C><N><S><R><C><R><C><G><Y><D><C><P><N><R><V><V><Q><K><G><I><R><Y><D><L><C><I><F><R><T><D><D><G><R><G><W><G><V><R><T><L><E><K><I><R><K><N><S><F><V><M><E><Y><V><G><E><I><I><T><S><E><E><A><E><R><R><G><Q><I><Y><D><R><Q><G><A><T><Y><L><F><D><L><D><Y><V><E><D><V><Y><T><V><D><A><A><Y><Y><G><N><I><S><H><F><V><N><H><S><C><D><P><N><L><Q><V><Y><N><V><F><I><D><N><L><D><E><R><L><P><R><I><A><F><F><A><T><R><T><I><R><A><G><E><E><L><T><F><D><Y><N><M><Q><V><D><P><V><D><M><E><S><T><R><M><D><S><N><F><G><L><A><G><L><P><G><S><P><K><K><R><V><R><I><E><C><K><C><G><T><E><S><C><R><K><Y><L><F> | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex | O43463 |
Q9H1J5 | WNT8A_HUMAN | Protein Wnt-8d | Homo | <M><G><N><L><F><M><L><W><A><A><L><G><I><C><C><A><A><F><S><A><S><A><W><S><V><N><N><F><L><I><T><G><P><K><A><Y><L><T><Y><T><T><S><V><A><L><G><A><Q><S><G><I><E><E><C><K><F><Q><F><A><W><E><R><W><N><C><P><E><N><A><L><Q><L><S><T><H><N><R><L><R><S><A><T><R><E><T><S><F><I><H><A><I><S><S><A><G><V><M><Y><I><I><T><K><N><C><S><M><G><D><F><E><N><C><G><C><D><G><S><N><N><G><K><T><G><G><H><G><W><I><W><G><G><C><S><D><N><V><E><F><G><E><R><I><S><K><L><F><V><D><S><L><E><K><G><K><D><A><R><A><L><M><N><L><H><N><N><R><A><G><R><L><A><V><R><A><T><M><K><R><T><C><K><C><H><G><I><S><G><S><C><S><I><Q><T><C><W><L><Q><L><A><E><F><R><E><M><G><D><Y><L><K><A><K><Y><D><Q><A><L><K><I><E><M><D><K><R><Q><L><R><A><G><N><S><A><E><G><H><W><V><P><A><E><A><F><L><P><S><A><E><A><E><L><I><F><L><E><E><S><P><D><Y><C><T><C><N><S><S><L><G><I><Y><G><T><E><G><R><E><C><L><Q><N><S><H><N><T><S><R><W><E><R><R><S><C><G><R><L><C><T><E><C><G><L><Q><V><E><E><R><K><T><E><V><I><S><S><C><N><C><K><F><Q><W><C><C><T><V><K><C><D><Q><C><R><H><V><V><S><K><Y><Y><C><A><R><S><P><G><S><A><Q><S><L><G><K><G><S><A> | Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.<BOP> | Q9H1J5 |
Q15631 | TSN_HUMAN | Component 3 of promoter of RISC | Homo | <M><S><V><S><E><I><F><V><E><L><Q><G><F><L><A><A><E><Q><D><I><R><E><E><I><R><K><V><V><Q><S><L><E><Q><T><A><R><E><I><L><T><L><L><Q><G><V><H><Q><G><A><G><F><Q><D><I><P><K><R><C><L><K><A><R><E><H><F><G><T><V><K><T><H><L><T><S><L><K><T><K><F><P><A><E><Q><Y><Y><R><F><H><E><H><W><R><F><V><L><Q><R><L><V><F><L><A><A><F><V><V><Y><L><E><T><E><T><L><V><T><R><E><A><V><T><E><I><L><G><I><E><P><D><R><E><K><G><F><H><L><D><V><E><D><Y><L><S><G><V><L><I><L><A><S><E><L><S><R><L><S><V><N><S><V><T><A><G><D><Y><S><R><P><L><H><I><S><T><F><I><N><E><L><D><S><G><F><R><L><L><N><L><K><N><D><S><L><R><K><R><Y><D><G><L><K><Y><D><V><K><K><V><E><E><V><V><Y><D><L><S><I><R><G><F><N><K><E><T><A><A><A><C><V><E><K> | Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<BOP> | Q15631 |
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