accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q8NHW5
RLA0L_HUMAN
Large ribosomal subunit protein uL10-like
Homo
<M><P><R><E><D><R><A><T><W><K><S><N><Y><F><L><K><I><I><Q><L><L><D><D><Y><P><K><C><F><I><V><G><A><D><N><V><G><S><K><Q><M><Q><Q><I><R><M><S><L><R><G><K><V><V><V><L><M><G><K><N><T><M><M><R><K><A><I><R><G><H><L><E><N><N><P><A><L><E><K><L><L><P><H><I><W><G><N><V><G><F><V><F><T><K><E><D><L><T><E><I><R><D><M><L><L><A><N><K><V><P><A><A><A><R><A><G><A><I><A><P><C><E><V><T><V><P><A><Q><N><T><G><L><G><P><E><K><T><S><F><F><Q><A><L><G><I><T><T><K><I><S><R><G><T><I><E><I><L><S><D><V><Q><L><I><K><T><G><D><K><V><G><A><S><E><A><T><L><L><N><M><L><N><I><S><P><F><S><F><G><L><V><I><Q><Q><V><F><D><N><G><S><I><Y><N><P><E><V><L><D><K><T><E><E><T><L><H><S><R><F><L><E><G><V><R><N><V><A><S><V><C><L><Q><T><G><Y><P><T><V><A><S><V><P><H><S><I><I><N><G><Y><K><R><V><L><A><L><S><V><E><T><D><Y><T><F><P><L><A><E><N><V><K><A><F><L><A><D><P><S><A><F><V><A><A><A><P><V><A><A><D><T><T><A><A><P><A><A><A><A><A><P><A><K><V><E><A><K><E><E><S><E><E><S><D><E><D><M><G><F><G><L><F><D>
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.<BOP>
Q8NHW5
Q9H8X2
IPPK_HUMAN
Ins(1,3,4,5,6)P5 2-kinase
Homo
<M><E><E><G><K><M><D><E><N><E><W><G><Y><H><G><E><G><N><K><S><L><V><V><A><H><A><Q><R><C><V><V><L><R><F><L><K><F><P><P><N><R><K><K><T><S><E><E><I><F><Q><H><L><Q><N><I><V><D><F><G><K><N><V><M><K><E><F><L><G><E><N><Y><V><H><Y><G><E><V><V><Q><L><P><L><E><F><V><K><Q><L><C><L><K><I><Q><S><E><R><P><E><S><R><C><D><K><D><L><D><T><L><S><G><Y><A><M><C><L><P><N><L><T><R><L><Q><T><Y><R><F><A><E><H><R><P><I><L><C><V><E><I><K><P><K><C><G><F><I><P><F><S><S><D><V><T><H><E><M><K><H><K><V><C><R><Y><C><M><H><Q><H><L><K><V><A><T><G><K><W><K><Q><I><S><K><Y><C><P><L><D><L><Y><S><G><N><K><Q><R><M><H><F><A><L><K><S><L><L><Q><E><A><Q><N><N><L><K><I><F><K><N><G><E><L><I><Y><G><C><K><D><A><R><S><P><V><A><D><W><S><E><L><A><H><H><L><K><P><F><F><F><P><S><N><G><L><A><S><G><P><H><C><T><R><A><V><I><R><E><L><V><H><V><I><T><R><V><L><L><S><G><S><D><K><G><R><A><G><T><L><S><P><G><L><G><P><Q><G><P><R><V><C><E><A><S><P><F><S><R><S><L><R><C><Q><G><K><N><T><P><E><R><S><G><L><P><K><G><C><L><L><Y><K><T><L><Q><V><Q><M><L><D><L><L><D><I><E><G><L><Y><P><L><Y><N><R><V><E><R><Y><L><E><E><F><P><E><E><R><K><T><L><Q><I><D><G><P><Y><D><E><A><F><Y><Q><K><L><L><D><L><S><T><E><D><D><G><T><V><A><F><A><L><T><K><V><Q><Q><Y><R><V><A><M><T><A><K><D><C><S><I><M><I><A><L><S><P><C><L><Q><D><A><S><S><D><Q><R><P><V><V><P><S><S><R><S><R><F><A><F><S><V><S><V><L><D><L><D><L><K><P><Y><E><S><I><P><H><Q><Y><K><L><D><G><K><I><V><N><Y><Y><S><K><T><V><R><A><K><D><N><A><V><M><S><T><R><F><K><E><S><E><D><C><T><L><V><L><H><K><V>
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.<BOP>
Q9H8X2
P0DP04
HV43D_HUMAN
Immunoglobulin heavy variable 3-43D
Homo
<M><E><F><G><L><S><W><V><F><L><V><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><V><V><V><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><D><D><Y><A><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><S><L><I><S><W><D><G><G><S><T><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><S><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><L><Y><Y><C><A><K><D>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DP04
Q8WVZ7
RN133_HUMAN
RING-type E3 ubiquitin transferase RNF133
Homo
<M><H><L><L><K><V><G><T><W><R><N><N><T><A><S><S><W><L><M><K><F><S><V><L><W><L><V><S><Q><N><C><C><R><A><S><V><V><W><M><A><Y><M><N><I><S><F><H><V><G><N><H><V><L><S><E><L><G><E><T><G><V><F><G><R><S><S><T><L><K><R><V><A><G><V><I><V><P><P><E><G><K><I><Q><N><A><C><N><P><N><T><I><F><S><R><S><K><Y><S><E><T><W><L><A><L><I><E><R><G><G><C><T><F><T><Q><K><I><K><V><A><T><E><K><G><A><S><G><V><I><I><Y><N><V><P><G><T><G><N><Q><V><F><P><M><F><H><Q><A><F><E><D><V><V><V><V><M><I><G><N><L><K><G><T><E><I><F><H><L><I><K><K><G><V><L><I><T><A><V><V><E><V><G><R><K><H><I><I><W><M><N><H><Y><L><V><S><F><V><I><V><T><T><A><T><L><A><Y><F><I><F><Y><H><I><H><R><L><C><L><A><R><I><Q><N><R><R><W><Q><R><L><T><T><D><L><Q><N><T><F><G><Q><L><Q><L><R><V><V><K><E><G><D><E><E><I><N><P><N><G><D><S><C><V><I><C><F><E><R><Y><K><P><N><D><I><V><R><I><L><T><C><K><H><F><F><H><K><N><C><I><D><P><W><I><L><P><H><G><T><C><P><I><C><K><C><D><I><L><K><V><L><G><I><Q><V><V><V><E><N><G><T><E><P><L><Q><V><L><M><S><N><E><L><P><E><T><L><S><P><S><E><E><E><T><N><N><E><V><S><P><A><G><T><S><D><K><V><I><H><V><E><E><N><P><T><S><Q><N><N><D><I><Q><P><H><S><V><V><E><D><V><H><P><S><P>
Has E3 ubiquitin-protein ligase activity.<BOP>
Q8WVZ7
Q86XF0
DYR2_HUMAN
Dihydrofolate reductase-like protein 1
Homo
<M><F><L><L><L><N><C><I><V><A><V><S><Q><N><M><G><I><G><K><N><G><D><L><P><R><P><P><L><R><N><E><F><R><Y><F><Q><R><M><T><T><T><S><S><V><E><G><K><Q><N><L><V><I><M><G><R><K><T><W><F><S><I><P><E><K><N><R><P><L><K><D><R><I><N><L><V><L><S><R><E><L><K><E><P><P><Q><G><A><H><F><L><A><R><S><L><D><D><A><L><K><L><T><E><R><P><E><L><A><N><K><V><D><M><I><W><I><V><G><G><S><S><V><Y><K><E><A><M><N><H><L><G><H><L><K><L><F><V><T><R><I><M><Q><D><F><E><S><D><T><F><F><S><E><I><D><L><E><K><Y><K><L><L><P><E><Y><P><G><V><L><S><D><V><Q><E><G><K><H><I><K><Y><K><F><E><V><C><E><K><D><D>
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.<BOP>
Q86XF0
Q9NZ72
STMN3_HUMAN
SCG10-like protein
Homo
<M><A><S><T><I><S><A><Y><K><E><K><M><K><E><L><S><V><L><S><L><I><C><S><C><F><Y><T><Q><P><H><P><N><T><V><Y><Q><Y><G><D><M><E><V><K><Q><L><D><K><R><A><S><G><Q><S><F><E><V><I><L><K><S><P><S><D><L><S><P><E><S><P><M><L><S><S><P><P><K><K><K><D><T><S><L><E><E><L><Q><K><R><L><E><A><A><E><E><R><R><K><T><Q><E><A><Q><V><L><K><Q><L><A><E><R><R><E><H><E><R><E><V><L><H><K><A><L><E><E><N><N><N><F><S><R><Q><A><E><E><K><L><N><Y><K><M><E><L><S><K><E><I><R><E><A><H><L><A><A><L><R><E><R><L><R><E><K><E><L><H><A><A><E><V><R><R><N><K><E><Q><R><E><E><M><S><G>
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.<BOP>
Q9NZ72
Q6PD74
AAGAB_HUMAN
Alpha- and gamma-adaptin-binding protein p34
Homo
<M><A><A><G><V><P><C><A><L><V><T><S><C><S><S><V><F><S><G><D><Q><L><V><Q><H><I><L><G><T><E><D><L><I><V><E><V><T><S><N><D><A><V><R><F><Y><P><W><T><I><D><N><K><Y><Y><S><A><D><I><N><L><C><V><V><P><N><K><F><L><V><T><A><E><I><A><E><S><V><Q><A><F><V><V><Y><F><D><S><T><Q><K><S><G><L><D><S><V><S><S><W><L><P><L><A><K><A><W><L><P><E><V><M><I><L><V><C><D><R><V><S><E><D><G><I><N><R><Q><K><A><Q><E><W><C><I><K><H><G><F><E><L><V><E><L><S><P><E><E><L><P><E><E><D><D><D><F><P><E><S><T><G><V><K><R><I><V><Q><A><L><N><A><N><V><W><S><N><V><V><M><K><N><D><R><N><Q><G><F><S><L><L><N><S><L><T><G><T><N><H><S><I><G><S><A><D><P><C><H><P><E><Q><P><H><L><P><A><A><D><S><T><E><S><L><S><D><H><R><G><G><A><S><N><T><T><D><A><Q><V><D><S><I><V><D><P><M><L><D><L><D><I><Q><E><L><A><S><L><T><T><G><G><G><D><V><E><N><F><E><R><L><F><S><K><L><K><E><M><K><D><K><A><A><T><L><P><H><E><Q><R><K><V><H><A><E><K><V><A><K><A><F><W><M><A><I><G><G><D><R><D><E><I><E><G><L><S><S><D><E><E><H>
May be involved in endocytic recycling of growth factor receptors such as EGFR.<BOP>
Q6PD74
P51161
FABP6_HUMAN
Intestinal bile acid-binding protein
Homo
<M><A><F><T><G><K><F><E><M><E><S><E><K><N><Y><D><E><F><M><K><L><L><G><I><S><S><D><V><I><E><K><A><R><N><F><K><I><V><T><E><V><Q><Q><D><G><Q><D><F><T><W><S><Q><H><Y><S><G><G><H><T><M><T><N><K><F><T><V><G><K><E><S><N><I><Q><T><M><G><G><K><T><F><K><A><T><V><Q><M><E><G><G><K><L><V><V><N><F><P><N><Y><H><Q><T><S><E><I><V><G><D><K><L><V><E><V><S><T><I><G><G><V><T><Y><E><R><V><S><K><R><L><A>
Essential for the survival of colon cancer cells to bile acid-induced apoptosis.<BOP>
P51161
Q14332
FZD2_HUMAN
FzE2
Homo
<M><R><P><R><S><A><L><P><R><L><L><L><P><L><L><L><L><P><A><A><G><P><A><Q><F><H><G><E><K><G><I><S><I><P><D><H><G><F><C><Q><P><I><S><I><P><L><C><T><D><I><A><Y><N><Q><T><I><M><P><N><L><L><G><H><T><N><Q><E><D><A><G><L><E><V><H><Q><F><Y><P><L><V><K><V><Q><C><S><P><E><L><R><F><F><L><C><S><M><Y><A><P><V><C><T><V><L><E><Q><A><I><P><P><C><R><S><I><C><E><R><A><R><Q><G><C><E><A><L><M><N><K><F><G><F><Q><W><P><E><R><L><R><C><E><H><F><P><R><H><G><A><E><Q><I><C><V><G><Q><N><H><S><E><D><G><A><P><A><L><L><T><T><A><P><P><P><G><L><Q><P><G><A><G><G><T><P><G><G><P><G><G><G><G><A><P><P><R><Y><A><T><L><E><H><P><F><H><C><P><R><V><L><K><V><P><S><Y><L><S><Y><K><F><L><G><E><R><D><C><A><A><P><C><E><P><A><R><P><D><G><S><M><F><F><S><Q><E><E><T><R><F><A><R><L><W><I><L><T><W><S><V><L><C><C><A><S><T><F><F><T><V><T><T><Y><L><V><D><M><Q><R><F><R><Y><P><E><R><P><I><I><F><L><S><G><C><Y><T><M><V><S><V><A><Y><I><A><G><F><V><L><Q><E><R><V><V><C><N><E><R><F><S><E><D><G><Y><R><T><V><V><Q><G><T><K><K><E><G><C><T><I><L><F><M><M><L><Y><F><F><S><M><A><S><S><I><W><W><V><I><L><S><L><T><W><F><L><A><A><G><M><K><W><G><H><E><A><I><E><A><N><S><Q><Y><F><H><L><A><A><W><A><V><P><A><V><K><T><I><T><I><L><A><M><G><Q><I><D><G><D><L><L><S><G><V><C><F><V><G><L><N><S><L><D><P><L><R><G><F><V><L><A><P><L><F><V><Y><L><F><I><G><T><S><F><L><L><A><G><F><V><S><L><F><R><I><R><T><I><M><K><H><D><G><T><K><T><E><K><L><E><R><L><M><V><R><I><G><V><F><S><V><L><Y><T><V><P><A><T><I><V><I><A><C><Y><F><Y><E><Q><A><F><R><E><H><W><E><R><S><W><V><S><Q><H><C><K><S><L><A><I><P><C><P><A><H><Y><T><P><R><M><S><P><D><F><T><V><Y><M><I><K><Y><L><M><T><L><I><V><G><I><T><S><G><F><W><I><W><S><G><K><T><L><H><S><W><R><K><F><Y><T><R><L><T><N><S><R><H><G><E><T><T><V>
(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium . TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling .<BOP>
Q14332
Q8NBN3
TM87A_HUMAN
Transmembrane protein 87A
Homo
<M><A><A><A><A><W><L><Q><V><L><P><V><I><L><L><L><L><G><A><H><P><S><P><L><S><F><F><S><A><G><P><A><T><V><A><A><A><D><R><S><K><W><H><I><P><I><P><S><G><K><N><Y><F><S><F><G><K><I><L><F><R><N><T><T><I><F><L><K><F><D><G><E><P><C><D><L><S><L><N><I><T><W><Y><L><K><S><A><D><C><Y><N><E><I><Y><N><F><K><A><E><E><V><E><L><Y><L><E><K><L><K><E><K><R><G><L><S><G><K><Y><Q><T><S><S><K><L><F><Q><N><C><S><E><L><F><K><T><Q><T><F><S><G><D><F><M><H><R><L><P><L><L><G><E><K><Q><E><A><K><E><N><G><T><N><L><T><F><I><G><D><K><T><A><M><H><E><P><L><Q><T><W><Q><D><A><P><Y><I><F><I><V><H><I><G><I><S><S><S><K><E><S><S><K><E><N><S><L><S><N><L><F><T><M><T><V><E><V><K><G><P><Y><E><Y><L><T><L><E><D><Y><P><L><M><I><F><F><M><V><M><C><I><V><Y><V><L><F><G><V><L><W><L><A><W><S><A><C><Y><W><R><D><L><L><R><I><Q><F><W><I><G><A><V><I><F><L><G><M><L><E><K><A><V><F><Y><A><E><F><Q><N><I><R><Y><K><G><E><S><V><Q><G><A><L><I><L><A><E><L><L><S><A><V><K><R><S><L><A><R><T><L><V><I><I><V><S><L><G><Y><G><I><V><K><P><R><L><G><V><T><L><H><K><V><V><V><A><G><A><L><Y><L><L><F><S><G><M><E><G><V><L><R><V><T><G><A><Q><T><D><L><A><S><L><A><F><I><P><L><A><F><L><D><T><A><L><C><W><W><I><F><I><S><L><T><Q><T><M><K><L><L><K><L><R><R><N><I><V><K><L><S><L><Y><R><H><F><T><N><T><L><I><L><A><V><A><A><S><I><V><F><I><I><W><T><T><M><K><F><R><I><V><T><C><Q><S><D><W><R><E><L><W><V><D><D><A><I><W><R><L><L><F><S><M><I><L><F><V><I><M><V><L><W><R><P><S><A><N><N><Q><R><F><A><F><S><P><L><S><E><E><E><E><E><D><E><Q><K><E><P><M><L><K><E><S><F><E><G><M><K><M><R><S><T><K><Q><E><P><N><G><N><S><K><V><N><K><A><Q><E><D><D><L><K><W><V><E><E><N><V><P><S><S><V><T><D><V><A><L><P><A><L><L><D><S><D><E><E><R><M><I><T><H><F><E><R><S><K><M><E>
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).<BOP>
Q8NBN3
Q8WTW4
NPRL2_HUMAN
Tumor suppressor candidate 4
Homo
<M><G><S><G><C><R><I><E><C><I><F><F><S><E><F><H><P><T><L><G><P><K><I><T><Y><Q><V><P><E><D><F><I><S><R><E><L><F><D><T><V><Q><V><Y><I><I><T><K><P><E><L><Q><N><K><L><I><T><V><T><A><M><E><K><K><L><I><G><C><P><V><C><I><E><H><K><K><Y><S><R><N><A><L><L><F><N><L><G><F><V><C><D><A><Q><A><K><T><C><A><L><E><P><I><V><K><K><L><A><G><Y><L><T><T><L><E><L><E><S><S><F><V><S><M><E><E><S><K><Q><K><L><V><P><I><M><T><I><L><L><E><E><L><N><A><S><G><R><C><T><L><P><I><D><E><S><N><T><I><H><L><K><V><I><E><Q><R><P><D><P><P><V><A><Q><E><Y><D><V><P><V><F><T><K><D><K><E><D><F><F><N><S><Q><W><D><L><T><T><Q><Q><I><L><P><Y><I><D><G><F><R><H><I><Q><K><I><S><A><E><A><D><V><E><L><N><L><V><R><I><A><I><Q><N><L><L><Y><Y><G><V><V><T><L><V><S><I><L><Q><Y><S><N><V><Y><C><P><T><P><K><V><Q><D><L><V><D><D><K><S><L><Q><E><A><C><L><S><Y><V><T><K><Q><G><H><K><R><A><S><L><R><D><V><F><Q><L><Y><C><S><L><S><P><G><T><T><V><R><D><L><I><G><R><H><P><Q><Q><L><Q><H><V><D><E><R><K><L><I><Q><F><G><L><M><K><N><L><I><R><R><L><Q><K><Y><P><V><R><V><T><R><E><E><Q><S><H><P><A><R><L><Y><T><G><C><H><S><Y><D><E><I><C><C><K><T><G><M><S><Y><H><E><L><D><E><R><L><E><N><D><P><N><I><I><I><C><W><K>
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.<BOP>
Q8WTW4
Q13042
CDC16_HUMAN
Cyclosome subunit 6
Homo
<M><N><L><E><R><L><R><K><R><V><R><Q><Y><L><D><Q><Q><Q><Y><Q><S><A><L><F><W><A><D><K><V><A><S><L><S><R><E><E><P><Q><D><I><Y><W><L><A><Q><C><L><Y><L><T><A><Q><Y><H><R><A><A><H><A><L><R><S><R><K><L><D><K><L><Y><E><A><C><R><Y><L><A><A><R><C><H><Y><A><A><K><E><H><Q><Q><A><L><D><V><L><D><M><E><E><P><I><N><K><R><L><F><E><K><Y><L><K><D><E><S><G><F><K><D><P><S><S><D><W><E><M><S><Q><S><S><I><K><S><S><I><C><L><L><R><G><K><I><Y><D><A><L><D><N><R><T><L><A><T><Y><S><Y><K><E><A><L><K><L><D><V><Y><C><F><E><A><F><D><L><L><T><S><H><H><M><L><T><A><Q><E><E><K><E><L><L><E><S><L><P><L><S><K><L><C><N><E><E><Q><E><L><L><R><F><L><F><E><N><K><L><K><K><Y><N><K><P><S><E><T><V><I><P><E><S><V><D><G><L><Q><E><N><L><D><V><V><V><S><L><A><E><R><H><Y><Y><N><C><D><F><K><M><C><Y><K><L><T><S><V><V><M><E><K><D><P><F><H><A><S><C><L><P><V><H><I><G><T><L><V><E><L><N><K><A><N><E><L><F><Y><L><S><H><K><L><V><D><L><Y><P><S><N><P><V><S><W><F><A><V><G><C><Y><Y><L><M><V><G><H><K><N><E><H><A><R><R><Y><L><S><K><A><T><T><L><E><K><T><Y><G><P><A><W><I><A><Y><G><H><S><F><A><V><E><S><E><H><D><Q><A><M><A><A><Y><F><T><A><A><Q><L><M><K><G><C><H><L><P><M><L><Y><I><G><L><E><Y><G><L><T><N><N><S><K><L><A><E><R><F><F><S><Q><A><L><S><I><A><P><E><D><P><F><V><M><H><E><V><G><V><V><A><F><Q><N><G><E><W><K><T><A><E><K><W><F><L><D><A><L><E><K><I><K><A><I><G><N><E><V><T><V><D><K><W><E><P><L><L><N><N><L><G><H><V><C><R><K><L><K><K><Y><A><E><A><L><D><Y><H><R><Q><A><L><V><L><I><P><Q><N><A><S><T><Y><S><A><I><G><Y><I><H><S><L><M><G><N><F><E><N><A><V><D><Y><F><H><T><A><L><G><L><R><R><D><D><T><F><S><V><T><M><L><G><H><C><I><E><M><Y><I><G><D><S><E><A><Y><I><G><A><D><I><K><D><K><L><K><C><Y><D><F><D><V><H><T><M><K><T><L><K><N><I><I><S><P><P><W><D><F><R><E><F><E><V><E><K><Q><T><A><E><E><T><G><L><T><P><L><E><T><S><R><K><T><P><D><S><R><P><S><L><E><E><T><F><E><I><E><M><N><E><S><D><M><M><L><E><T><S><M><S><D><H><S><T>
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<BOP>
Q13042
Q8IU54
IFNL1_HUMAN
Interleukin-29
Homo
<M><A><A><A><W><T><V><V><L><V><T><L><V><L><G><L><A><V><A><G><P><V><P><T><S><K><P><T><T><T><G><K><G><C><H><I><G><R><F><K><S><L><S><P><Q><E><L><A><S><F><K><K><A><R><D><A><L><E><E><S><L><K><L><K><N><W><S><C><S><S><P><V><F><P><G><N><W><D><L><R><L><L><Q><V><R><E><R><P><V><A><L><E><A><E><L><A><L><T><L><K><V><L><E><A><A><A><G><P><A><L><E><D><V><L><D><Q><P><L><H><T><L><H><H><I><L><S><Q><L><Q><A><C><I><Q><P><Q><P><T><A><G><P><R><P><R><G><R><L><H><H><W><L><H><R><L><Q><E><A><P><K><K><E><S><A><G><C><L><E><A><S><V><T><F><N><L><F><R><L><L><T><R><D><L><K><Y><V><A><D><G><N><L><C><L><R><T><S><T><H><P><E><S><T>
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.<BOP>
Q8IU54
P34969
5HT7R_HUMAN
Serotonin receptor 7
Homo
<M><M><D><V><N><S><S><G><R><P><D><L><Y><G><H><L><R><S><F><L><L><P><E><V><G><R><G><L><P><D><L><S><P><D><G><G><A><D><P><V><A><G><S><W><A><P><H><L><L><S><E><V><T><A><S><P><A><P><T><W><D><A><P><P><D><N><A><S><G><C><G><E><Q><I><N><Y><G><R><V><E><K><V><V><I><G><S><I><L><T><L><I><T><L><L><T><I><A><G><N><C><L><V><V><I><S><V><C><F><V><K><K><L><R><Q><P><S><N><Y><L><I><V><S><L><A><L><A><D><L><S><V><A><V><A><V><M><P><F><V><S><V><T><D><L><I><G><G><K><W><I><F><G><H><F><F><C><N><V><F><I><A><M><D><V><M><C><C><T><A><S><I><M><T><L><C><V><I><S><I><D><R><Y><L><G><I><T><R><P><L><T><Y><P><V><R><Q><N><G><K><C><M><A><K><M><I><L><S><V><W><L><L><S><A><S><I><T><L><P><P><L><F><G><W><A><Q><N><V><N><D><D><K><V><C><L><I><S><Q><D><F><G><Y><T><I><Y><S><T><A><V><A><F><Y><I><P><M><S><V><M><L><F><M><Y><Y><Q><I><Y><K><A><A><R><K><S><A><A><K><H><K><F><P><G><F><P><R><V><E><P><D><S><V><I><A><L><N><G><I><V><K><L><Q><K><E><V><E><E><C><A><N><L><S><R><L><L><K><H><E><R><K><N><I><S><I><F><K><R><E><Q><K><A><A><T><T><L><G><I><I><V><G><A><F><T><V><C><W><L><P><F><F><L><L><S><T><A><R><P><F><I><C><G><T><S><C><S><C><I><P><L><W><V><E><R><T><F><L><W><L><G><Y><A><N><S><L><I><N><P><F><I><Y><A><F><F><N><R><D><L><R><T><T><Y><R><S><L><L><Q><C><Q><Y><R><N><I><N><R><K><L><S><A><A><G><M><H><E><A><L><K><L><A><E><R><P><E><R><P><E><F><V><L><R><A><C><T><R><R><V><L><L><R><P><E><K><R><P><P><V><S><V><W><V><L><Q><S><P><D><H><H><N><W><L><A><D><K><M><L><T><T><V><E><K><K><V><M><I><H><D>
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.<BOP>
P34969
Q7Z5R6
AB1IP_HUMAN
Retinoic acid-responsive proline-rich protein 1
Homo
<M><G><E><S><S><E><D><I><D><Q><M><F><S><T><L><L><G><E><M><D><L><L><T><Q><S><L><G><V><D><T><L><P><P><P><D><P><N><P><P><R><A><E><F><N><Y><S><V><G><F><K><D><L><N><E><S><L><N><A><L><E><D><Q><D><L><D><A><L><M><A><D><L><V><A><D><I><S><E><A><E><Q><R><T><I><Q><A><Q><K><E><S><L><Q><N><Q><H><H><S><A><S><L><Q><A><S><I><F><S><G><A><A><S><L><G><Y><G><T><N><V><A><A><T><G><I><S><Q><Y><E><D><D><L><P><P><P><P><A><D><P><V><L><D><L><P><L><P><P><P><P><P><E><P><L><S><Q><E><E><E><E><A><Q><A><K><A><D><K><I><K><L><A><L><E><K><L><K><E><A><K><V><K><K><L><V><V><K><V><H><M><N><D><N><S><T><K><S><L><M><V><D><E><R><Q><L><A><R><D><V><L><D><N><L><F><E><K><T><H><C><D><C><N><V><D><W><C><L><Y><E><I><Y><P><E><L><Q><I><E><R><F><F><E><D><H><E><N><V><V><E><V><L><S><D><W><T><R><D><T><E><N><K><I><L><F><L><E><K><E><E><K><Y><A><V><F><K><N><P><Q><N><F><Y><L><D><N><R><G><K><K><E><S><K><E><T><N><E><K><M><N><A><K><N><K><E><S><L><L><E><E><S><F><C><G><T><S><I><I><V><P><E><L><E><G><A><L><Y><L><K><E><D><G><K><K><S><W><K><R><R><Y><F><L><L><R><A><S><G><I><Y><Y><V><P><K><G><K><T><K><T><S><R><D><L><A><C><F><I><Q><F><E><N><V><N><I><Y><Y><G><T><Q><H><K><M><K><Y><K><A><P><T><D><Y><C><F><V><L><K><H><P><Q><I><Q><K><E><S><Q><Y><I><K><Y><L><C><C><D><D><T><R><T><L><N><Q><W><V><M><G><I><R><I><A><K><Y><G><K><T><L><Y><D><N><Y><Q><R><A><V><A><K><A><G><L><A><S><R><W><T><N><L><G><T><V><N><A><A><A><P><A><Q><P><S><T><G><P><K><T><G><T><T><Q><P><N><G><Q><I><P><Q><A><T><H><S><V><S><A><V><L><Q><E><A><Q><R><H><A><E><T><S><K><D><K><K><P><A><L><G><N><H><H><D><P><A><V><P><R><A><P><H><A><P><K><S><S><L><P><P><P><P><P><V><R><R><S><S><D><T><S><G><S><P><A><T><P><L><K><A><K><G><T><G><G><G><G><L><P><A><P><P><D><D><F><L><P><P><P><P><P><P><P><P><L><D><D><P><E><L><P><P><P><P><P><D><F><M><E><P><P><P><D><F><V><P><P><P><P><P><S><Y><A><G><I><A><G><S><E><L><P><P><P><P><P><P><P><P><A><P><A><P><A><P><V><P><D><S><A><R><P><P><P><A><V><A><K><R><P><P><V><P><P><K><R><Q><E><N><P><G><H><P><G><G><A><G><G><G><E><Q><D><F><M><S><D><L><M><K><A><L><Q><K><K><R><G><N><V><S>
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.<BOP>
Q7Z5R6
Q9P2T0
THEG_HUMAN
Cancer/testis antigen 56
Homo
<M><G><D><S><R><R><R><S><L><G><N><Q><P><S><S><E><A><A><G><R><S><E><R><E><Q><D><G><D><P><R><G><L><Q><S><S><V><Y><E><S><R><R><V><T><D><P><E><R><Q><D><L><D><N><A><E><L><G><P><E><D><P><E><E><E><L><P><P><E><E><V><A><G><E><E><F><P><E><T><L><D><P><K><E><A><L><S><E><L><E><R><V><L><D><K><D><L><E><E><D><I><P><E><I><S><R><L><S><I><S><Q><K><L><P><S><T><T><M><T><K><A><R><K><R><R><R><R><R><R><L><M><E><L><A><E><P><K><I><N><W><Q><V><L><K><D><R><K><G><R><C><G><K><G><Y><A><W><I><S><P><C><K><M><S><L><H><F><C><L><C><W><P><S><V><Y><W><T><E><R><F><L><E><D><T><T><L><T><I><T><V><P><A><V><S><R><R><V><E><E><L><S><R><P><K><R><F><Y><L><E><Y><Y><N><N><N><R><T><T><P><V><W><P><I><P><R><S><S><L><E><Y><R><A><S><S><R><L><K><E><L><A><A><P><K><I><R><D><N><F><W><S><M><P><M><S><E><V><S><Q><V><S><R><A><A><Q><M><A><V><P><S><S><R><I><L><Q><L><S><K><P><K><A><P><A><T><L><L><E><E><W><D><P><V><P><K><P><K><P><H><V><S><D><H><N><R><L><L><H><L><A><R><P><K><A><Q><S><D><K><C><V><P><D><R><D><P><R><W><E><V><L><D><V><T><K><K><V><V><A><S><P><R><I><I><S><L><A><K><P><K><V><R><K><G><L><N><E><G><Y><D><R><R><P><L><A><S><M><S><L><P><P><P><K><A><S><P><E><K><C><D><Q><P><R><P><G><L>
May be involved (but not essential) in spermatogenesis.<BOP>
Q9P2T0
P61026
RAB10_HUMAN
Ras-related protein Rab-10
Homo
<M><A><K><K><T><Y><D><L><L><F><K><L><L><L><I><G><D><S><G><V><G><K><T><C><V><L><F><R><F><S><D><D><A><F><N><T><T><F><I><S><T><I><G><I><D><F><K><I><K><T><V><E><L><Q><G><K><K><I><K><L><Q><I><W><D><T><A><G><Q><E><R><F><H><T><I><T><T><S><Y><Y><R><G><A><M><G><I><M><L><V><Y><D><I><T><N><G><K><S><F><E><N><I><S><K><W><L><R><N><I><D><E><H><A><N><E><D><V><E><R><M><L><L><G><N><K><C><D><M><D><D><K><R><V><V><P><K><G><K><G><E><Q><I><A><R><E><H><G><I><R><F><F><E><T><S><A><K><A><N><I><N><I><E><K><A><F><L><T><L><A><E><D><I><L><R><K><T><P><V><K><E><P><N><S><E><N><V><D><I><S><S><G><G><G><V><T><G><W><K><S><K><C><C>
(Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.<BOP>
P61026
Q9NPH2
INO1_HUMAN
Myo-inositol 1-phosphate synthase A1
Homo
<M><E><A><A><A><Q><F><F><V><E><S><P><D><V><V><Y><G><P><E><A><I><E><A><Q><Y><E><Y><R><T><T><R><V><S><R><E><G><G><V><L><K><V><H><P><T><S><T><R><F><T><F><R><T><A><R><Q><V><P><R><L><G><V><M><L><V><G><W><G><G><N><N><G><S><T><L><T><A><A><V><L><A><N><R><L><R><L><S><W><P><T><R><S><G><R><K><E><A><N><Y><Y><G><S><L><T><Q><A><G><T><V><S><L><G><L><D><A><E><G><Q><E><V><F><V><P><F><S><A><V><L><P><M><V><A><P><N><D><L><V><F><D><G><W><D><I><S><S><L><N><L><A><E><A><M><R><R><A><K><V><L><D><W><G><L><Q><E><Q><L><W><P><H><M><E><A><L><R><P><R><P><S><V><Y><I><P><E><F><I><A><A><N><Q><S><A><R><A><D><N><L><I><P><G><S><R><A><Q><Q><L><E><Q><I><R><R><D><I><R><D><F><R><S><S><A><G><L><D><K><V><I><V><L><W><T><A><N><T><E><R><F><C><E><V><I><P><G><L><N><D><T><A><E><N><L><L><R><T><I><E><L><G><L><E><V><S><P><S><T><L><F><A><V><A><S><I><L><E><G><C><A><F><L><N><G><S><P><Q><N><T><L><V><P><G><A><L><E><L><A><W><Q><H><R><V><F><V><G><G><D><D><F><K><S><G><Q><T><K><V><K><S><V><L><V><D><F><L><I><G><S><G><L><K><T><M><S><I><V><S><Y><N><H><L><G><N><N><D><G><E><N><L><S><A><P><L><Q><F><R><S><K><E><V><S><K><S><N><V><V><D><D><M><V><Q><S><N><P><V><L><Y><T><P><G><E><E><P><D><H><C><V><V><I><K><Y><V><P><Y><V><G><D><S><K><R><A><L><D><E><Y><T><S><E><L><M><L><G><G><T><N><T><L><V><L><H><N><T><C><E><D><S><L><L><A><A><P><I><M><L><D><L><A><L><L><T><E><L><C><Q><R><V><S><F><C><T><D><M><D><P><E><P><Q><T><F><H><P><V><L><S><L><L><S><F><L><F><K><A><P><L><V><P><P><G><S><P><V><V><N><A><L><F><R><Q><R><S><C><I><E><N><I><L><R><A><C><V><G><L><P><P><Q><N><H><M><L><L><E><H><K><M><E><R><P><G><P><S><L><K><R><V><G><P><V><A><A><T><Y><P><M><L><N><K><K><G><P><V><P><A><A><T><N><G><C><T><G><D><A><N><G><H><L><Q><E><E><P><P><M><P><T><T>
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner . Rate-limiting enzyme in the synthesis of all inositol-containing compounds .<BOP>
Q9NPH2
Q32P28
P3H1_HUMAN
Leucine- and proline-enriched proteoglycan 1
Homo
<M><A><V><R><A><L><K><L><L><T><T><L><L><A><V><V><A><A><A><S><Q><A><E><V><E><S><E><A><G><W><G><M><V><T><P><D><L><L><F><A><E><G><T><A><A><Y><A><R><G><D><W><P><G><V><V><L><S><M><E><R><A><L><R><S><R><A><A><L><R><A><L><R><L><R><C><R><T><Q><C><A><A><D><F><P><W><E><L><D><P><D><W><S><P><S><P><A><Q><A><S><G><A><A><A><L><R><D><L><S><F><F><G><G><L><L><R><R><A><A><C><L><R><R><C><L><G><P><P><A><A><H><S><L><S><E><E><M><E><L><E><F><R><K><R><S><P><Y><N><Y><L><Q><V><A><Y><F><K><I><N><K><L><E><K><A><V><A><A><A><H><T><F><F><V><G><N><P><E><H><M><E><M><Q><Q><N><L><D><Y><Y><Q><T><M><S><G><V><K><E><A><D><F><K><D><L><E><T><Q><P><H><M><Q><E><F><R><L><G><V><R><L><Y><S><E><E><Q><P><Q><E><A><V><P><H><L><E><A><A><L><Q><E><Y><F><V><A><Y><E><E><C><R><A><L><C><E><G><P><Y><D><Y><D><G><Y><N><Y><L><E><Y><N><A><D><L><F><Q><A><I><T><D><H><Y><I><Q><V><L><N><C><K><Q><N><C><V><T><E><L><A><S><H><P><S><R><E><K><P><F><E><D><F><L><P><S><H><Y><N><Y><L><Q><F><A><Y><Y><N><I><G><N><Y><T><Q><A><V><E><C><A><K><T><Y><L><L><F><F><P><N><D><E><V><M><N><Q><N><L><A><Y><Y><A><A><M><L><G><E><E><H><T><R><S><I><G><P><R><E><S><A><K><E><Y><R><Q><R><S><L><L><E><K><E><L><L><F><F><A><Y><D><V><F><G><I><P><F><V><D><P><D><S><W><T><P><E><E><V><I><P><K><R><L><Q><E><K><Q><K><S><E><R><E><T><A><V><R><I><S><Q><E><I><G><N><L><M><K><E><I><E><T><L><V><E><E><K><T><K><E><S><L><D><V><S><R><L><T><R><E><G><G><P><L><L><Y><E><G><I><S><L><T><M><N><S><K><L><L><N><G><S><Q><R><V><V><M><D><G><V><I><S><D><H><E><C><Q><E><L><Q><R><L><T><N><V><A><A><T><S><G><D><G><Y><R><G><Q><T><S><P><H><T><P><N><E><K><F><Y><G><V><T><V><F><K><A><L><K><L><G><Q><E><G><K><V><P><L><Q><S><A><H><L><Y><Y><N><V><T><E><K><V><R><R><I><M><E><S><Y><F><R><L><D><T><P><L><Y><F><S><Y><S><H><L><V><C><R><T><A><I><E><E><V><Q><A><E><R><K><D><D><S><H><P><V><H><V><D><N><C><I><L><N><A><E><T><L><V><C><V><K><E><P><P><A><Y><T><F><R><D><Y><S><A><I><L><Y><L><N><G><D><F><D><G><G><N><F><Y><F><T><E><L><D><A><K><T><V><T><A><E><V><Q><P><Q><C><G><R><A><V><G><F><S><S><G><T><E><N><P><H><G><V><K><A><V><T><R><G><Q><R><C><A><I><A><L><W><F><T><L><D><P><R><H><S><E><R><D><R><V><Q><A><D><D><L><V><K><M><L><F><S><P><E><E><M><D><L><S><Q><E><Q><P><L><D><A><Q><Q><G><P><P><E><P><A><Q><E><S><L><S><G><S><E><S><K><P><K><D><E><L>
Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.<BOP>
Q32P28
Q5TDH0
DDI2_HUMAN
Protein DDI1 homolog 2
Homo
<M><L><L><T><V><Y><C><V><R><R><D><L><S><E><V><T><F><S><L><Q><V><D><A><D><F><E><L><H><N><F><R><A><L><C><E><L><E><S><G><I><P><A><A><E><S><Q><I><V><Y><A><E><R><P><L><T><D><N><H><R><S><L><A><S><Y><G><L><K><D><G><D><V><V><I><L><R><Q><K><E><N><A><D><P><R><P><P><V><Q><F><P><N><L><P><R><I><D><F><S><S><I><A><V><P><G><T><S><S><P><R><Q><R><Q><P><P><G><T><Q><Q><S><H><S><S><P><G><E><I><T><S><S><P><Q><G><L><D><N><P><A><L><L><R><D><M><L><L><A><N><P><H><E><L><S><L><L><K><E><R><N><P><P><L><A><E><A><L><L><S><G><D><L><E><K><F><S><R><V><L><V><E><Q><Q><Q><D><R><A><R><R><E><Q><E><R><I><R><L><F><S><A><D><P><F><D><L><E><A><Q><A><K><I><E><E><D><I><R><Q><Q><N><I><E><E><N><M><T><I><A><M><E><E><A><P><E><S><F><G><Q><V><V><M><L><Y><I><N><C><K><V><N><G><H><P><V><K><A><F><V><D><S><G><A><Q><M><T><I><M><S><Q><A><C><A><E><R><C><N><I><M><R><L><V><D><R><R><W><A><G><I><A><K><G><V><G><T><Q><K><I><I><G><R><V><H><L><A><Q><V><Q><I><E><G><D><F><L><P><C><S><F><S><I><L><E><E><Q><P><M><D><M><L><L><G><L><D><M><L><K><R><H><Q><C><S><I><D><L><K><K><N><V><L><V><I><G><T><T><G><S><Q><T><T><F><L><P><E><G><E><L><P><E><C><A><R><L><A><Y><G><A><G><R><E><D><V><R><P><E><E><I><A><D><Q><E><L><A><E><A><L><Q><K><S><A><E><D><A><E><R><Q><K><P>
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane . Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 . Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity .<BOP>
Q5TDH0
Q9UDX3
S14L4_HUMAN
Tocopherol-associated protein 3
Homo
<M><S><S><R><V><G><D><L><S><P><Q><Q><Q><E><A><L><A><R><F><R><E><N><L><Q><D><L><L><P><I><L><P><N><A><D><D><Y><F><L><L><R><W><L><R><A><R><N><F><D><L><Q><K><S><E><D><M><L><R><R><H><M><E><F><R><K><Q><Q><D><L><D><N><I><V><T><W><Q><P><P><E><V><I><Q><L><Y><D><S><G><G><L><C><G><Y><D><Y><E><G><C><P><V><Y><F><N><I><I><G><S><L><D><P><K><G><L><L><L><S><A><S><K><Q><D><M><I><R><K><R><I><K><V><C><E><L><L><L><H><E><C><E><L><Q><T><Q><K><L><G><R><K><I><E><M><A><L><M><V><F><D><M><E><G><L><S><L><K><H><L><W><K><P><A><V><E><V><Y><Q><Q><F><F><S><I><L><E><A><N><Y><P><E><T><L><K><N><L><I><V><I><R><A><P><K><L><F><P><V><A><F><N><L><V><K><S><F><M><S><E><E><T><R><R><K><I><V><I><L><G><D><N><W><K><Q><E><L><T><K><F><I><S><P><D><Q><L><P><V><E><F><G><G><T><M><T><D><P><D><G><N><P><K><C><L><T><K><I><N><Y><G><G><E><V><P><K><S><Y><Y><L><C><E><Q><V><R><L><Q><Y><E><H><T><R><S><V><G><R><G><S><S><L><Q><V><E><N><E><I><L><F><P><G><C><V><L><R><W><Q><F><A><S><D><G><G><D><I><G><F><G><V><F><L><K><T><K><M><G><E><Q><Q><S><A><R><E><M><T><E><V><L><P><S><Q><R><Y><N><A><H><M><V><P><E><D><G><S><L><T><C><L><Q><A><G><V><Y><V><L><R><F><D><N><T><Y><S><R><M><H><A><K><K><L><S><Y><T><V><E><V><L><L><P><D><K><A><S><E><E><T><L><Q><S><L><K><A><M><R><P><S><P><T><Q>
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.<BOP>
Q9UDX3
Q9NUM4
T106B_HUMAN
Transmembrane protein 106B
Homo
<M><G><K><S><L><S><H><L><P><L><H><S><S><K><E><D><A><Y><D><G><V><T><S><E><N><M><R><N><G><L><V><N><S><E><V><H><N><E><D><G><R><N><G><D><V><S><Q><F><P><Y><V><E><F><T><G><R><D><S><V><T><C><P><T><C><Q><G><T><G><R><I><P><R><G><Q><E><N><Q><L><V><A><L><I><P><Y><S><D><Q><R><L><R><P><R><R><T><K><L><Y><V><M><A><S><V><F><V><C><L><L><L><S><G><L><A><V><F><F><L><F><P><R><S><I><D><V><K><Y><I><G><V><K><S><A><Y><V><S><Y><D><V><Q><K><R><T><I><Y><L><N><I><T><N><T><L><N><I><T><N><N><N><Y><Y><S><V><E><V><E><N><I><T><A><Q><V><Q><F><S><K><T><V><I><G><K><A><R><L><N><N><I><T><I><I><G><P><L><D><M><K><Q><I><D><Y><T><V><P><T><V><I><A><E><E><M><S><Y><M><Y><D><F><C><T><L><I><S><I><K><V><H><N><I><V><L><M><M><Q><V><T><V><T><T><T><Y><F><G><H><S><E><Q><I><S><Q><E><R><Y><Q><Y><V><D><C><G><R><N><T><T><Y><Q><L><G><Q><S><E><Y><L><N><V><L><Q><P><Q><Q>
(Microbial infection) May act as a proviral host factor for SARS-CoV-2, but not for common cold coronaviruses HCoV-229E and HCoV-OC43.<BOP>
Q9NUM4
P31431
SDC4_HUMAN
Ryudocan core protein
Homo
<M><A><P><A><R><L><F><A><L><L><L><F><F><V><G><G><V><A><E><S><I><R><E><T><E><V><I><D><P><Q><D><L><L><E><G><R><Y><F><S><G><A><L><P><D><D><E><D><V><V><G><P><G><Q><E><S><D><D><F><E><L><S><G><S><G><D><L><D><D><L><E><D><S><M><I><G><P><E><V><V><H><P><L><V><P><L><D><N><H><I><P><E><R><A><G><S><G><S><Q><V><P><T><E><P><K><K><L><E><E><N><E><V><I><P><K><R><I><S><P><V><E><E><S><E><D><V><S><N><K><V><S><M><S><S><T><V><Q><G><S><N><I><F><E><R><T><E><V><L><A><A><L><I><V><G><G><I><V><G><I><L><F><A><V><F><L><I><L><L><L><M><Y><R><M><K><K><K><D><E><G><S><Y><D><L><G><K><K><P><I><Y><K><K><A><P><T><N><E><F><Y><A>
Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP .<BOP>
P31431
P41240
CSK_HUMAN
Protein-tyrosine kinase CYL
Homo
<M><S><A><I><Q><A><A><W><P><S><G><T><E><C><I><A><K><Y><N><F><H><G><T><A><E><Q><D><L><P><F><C><K><G><D><V><L><T><I><V><A><V><T><K><D><P><N><W><Y><K><A><K><N><K><V><G><R><E><G><I><I><P><A><N><Y><V><Q><K><R><E><G><V><K><A><G><T><K><L><S><L><M><P><W><F><H><G><K><I><T><R><E><Q><A><E><R><L><L><Y><P><P><E><T><G><L><F><L><V><R><E><S><T><N><Y><P><G><D><Y><T><L><C><V><S><C><D><G><K><V><E><H><Y><R><I><M><Y><H><A><S><K><L><S><I><D><E><E><V><Y><F><E><N><L><M><Q><L><V><E><H><Y><T><S><D><A><D><G><L><C><T><R><L><I><K><P><K><V><M><E><G><T><V><A><A><Q><D><E><F><Y><R><S><G><W><A><L><N><M><K><E><L><K><L><L><Q><T><I><G><K><G><E><F><G><D><V><M><L><G><D><Y><R><G><N><K><V><A><V><K><C><I><K><N><D><A><T><A><Q><A><F><L><A><E><A><S><V><M><T><Q><L><R><H><S><N><L><V><Q><L><L><G><V><I><V><E><E><K><G><G><L><Y><I><V><T><E><Y><M><A><K><G><S><L><V><D><Y><L><R><S><R><G><R><S><V><L><G><G><D><C><L><L><K><F><S><L><D><V><C><E><A><M><E><Y><L><E><G><N><N><F><V><H><R><D><L><A><A><R><N><V><L><V><S><E><D><N><V><A><K><V><S><D><F><G><L><T><K><E><A><S><S><T><Q><D><T><G><K><L><P><V><K><W><T><A><P><E><A><L><R><E><K><K><F><S><T><K><S><D><V><W><S><F><G><I><L><L><W><E><I><Y><S><F><G><R><V><P><Y><P><R><I><P><L><K><D><V><V><P><R><V><E><K><G><Y><K><M><D><A><P><D><G><C><P><P><A><V><Y><E><V><M><K><N><C><W><H><L><D><A><A><M><R><P><S><F><L><Q><L><R><E><Q><L><E><H><I><K><T><H><E><L><H><L>
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.<BOP>
P41240
P37288
V1AR_HUMAN
Vascular/hepatic-type arginine vasopressin receptor
Homo
<M><R><L><S><A><G><P><D><A><G><P><S><G><N><S><S><P><W><W><P><L><A><T><G><A><G><N><T><S><R><E><A><E><A><L><G><E><G><N><G><P><P><R><D><V><R><N><E><E><L><A><K><L><E><I><A><V><L><A><V><T><F><A><V><A><V><L><G><N><S><S><V><L><L><A><L><H><R><T><P><R><K><T><S><R><M><H><L><F><I><R><H><L><S><L><A><D><L><A><V><A><F><F><Q><V><L><P><Q><M><C><W><D><I><T><Y><R><F><R><G><P><D><W><L><C><R><V><V><K><H><L><Q><V><F><G><M><F><A><S><A><Y><M><L><V><V><M><T><A><D><R><Y><I><A><V><C><H><P><L><K><T><L><Q><Q><P><A><R><R><S><R><L><M><I><A><A><A><W><V><L><S><F><V><L><S><T><P><Q><Y><F><V><F><S><M><I><E><V><N><N><V><T><K><A><R><D><C><W><A><T><F><I><Q><P><W><G><S><R><A><Y><V><T><W><M><T><G><G><I><F><V><A><P><V><V><I><L><G><T><C><Y><G><F><I><C><Y><N><I><W><C><N><V><R><G><K><T><A><S><R><Q><S><K><G><A><E><Q><A><G><V><A><F><Q><K><G><F><L><L><A><P><C><V><S><S><V><K><S><I><S><R><A><K><I><R><T><V><K><M><T><F><V><I><V><T><A><Y><I><V><C><W><A><P><F><F><I><I><Q><M><W><S><V><W><D><P><M><S><V><W><T><E><S><E><N><P><T><I><T><I><T><A><L><L><G><S><L><N><S><C><C><N><P><W><I><Y><M><F><F><S><G><H><L><L><Q><D><C><V><Q><S><F><P><C><C><Q><N><M><K><E><K><F><N><K><E><D><T><D><S><M><S><R><R><Q><T><F><Y><S><N><N><R><S><P><T><N><S><T><G><M><W><K><D><S><P><K><S><S><K><S><I><K><F><I><P><V><S><T>
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.<BOP>
P37288
Q6ZMR3
LDH6A_HUMAN
L-lactate dehydrogenase A-like 6A
Homo
<M><A><T><I><K><S><E><L><I><K><N><F><A><E><E><E><A><I><H><H><N><K><I><S><I><V><G><T><G><S><V><G><V><A><C><A><I><S><I><L><L><K><G><L><S><D><E><L><V><L><V><D><V><D><E><G><K><L><K><G><E><T><M><D><L><Q><H><G><S><P><F><M><K><M><P><N><I><V><S><S><K><D><Y><L><V><T><A><N><S><N><L><V><I><I><T><A><G><A><R><Q><K><K><G><E><T><R><L><D><L><V><Q><R><N><V><S><I><F><K><L><M><I><P><N><I><T><Q><Y><S><P><H><C><K><L><L><I><V><T><N><P><V><D><I><L><T><Y><V><A><W><K><L><S><G><F><P><K><N><R><V><I><G><S><G><C><N><L><D><S><A><R><F><R><Y><F><I><G><Q><R><L><G><I><H><S><E><S><C><H><G><L><I><L><G><E><H><G><D><S><S><V><P><V><W><S><G><V><N><I><A><G><V><P><L><K><D><L><N><P><D><I><G><T><D><K><D><P><E><Q><W><E><N><V><H><K><K><V><I><S><S><G><Y><E><M><V><K><M><K><G><Y><T><S><W><G><I><S><L><S><V><A><D><L><T><E><S><I><L><K><N><L><R><R><V><H><P><V><S><T><L><S><K><G><L><Y><G><I><N><E><D><I><F><L><S><V><P><C><I><L><G><E><N><G><I><T><D><L><I><K><V><K><L><T><L><E><E><E><A><C><L><Q><K><S><A><E><T><L><W><E><I><Q><K><E><L><K><L>
Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme . Significantly increases the transcriptional activity of JUN, when overexpressed.<BOP>
Q6ZMR3
Q9UJS0
S2513_HUMAN
Solute carrier family 25 member 13
Homo
<M><A><A><A><K><V><A><L><T><K><R><A><D><P><A><E><L><R><T><I><F><L><K><Y><A><S><I><E><K><N><G><E><F><F><M><S><P><N><D><F><V><T><R><Y><L><N><I><F><G><E><S><Q><P><N><P><K><T><V><E><L><L><S><G><V><V><D><Q><T><K><D><G><L><I><S><F><Q><E><F><V><A><F><E><S><V><L><C><A><P><D><A><L><F><M><V><A><F><Q><L><F><D><K><A><G><K><G><E><V><T><F><E><D><V><K><Q><V><F><G><Q><T><T><I><H><Q><H><I><P><F><N><W><D><S><E><F><V><Q><L><H><F><G><K><E><R><K><R><H><L><T><Y><A><E><F><T><Q><F><L><L><E><I><Q><L><E><H><A><K><Q><A><F><V><Q><R><D><N><A><R><T><G><R><V><T><A><I><D><F><R><D><I><M><V><T><I><R><P><H><V><L><T><P><F><V><E><E><C><L><V><A><A><A><G><G><T><T><S><H><Q><V><S><F><S><Y><F><N><G><F><N><S><L><L><N><N><M><E><L><I><R><K><I><Y><S><T><L><A><G><T><R><K><D><V><E><V><T><K><E><E><F><V><L><A><A><Q><K><F><G><Q><V><T><P><M><E><V><D><I><L><F><Q><L><A><D><L><Y><E><P><R><G><R><M><T><L><A><D><I><E><R><I><A><P><L><E><E><G><T><L><P><F><N><L><A><E><A><Q><R><Q><K><A><S><G><D><S><A><R><P><V><L><L><Q><V><A><E><S><A><Y><R><F><G><L><G><S><V><A><G><A><V><G><A><T><A><V><Y><P><I><D><L><V><K><T><R><M><Q><N><Q><R><S><T><G><S><F><V><G><E><L><M><Y><K><N><S><F><D><C><F><K><K><V><L><R><Y><E><G><F><F><G><L><Y><R><G><L><L><P><Q><L><L><G><V><A><P><E><K><A><I><K><L><T><V><N><D><F><V><R><D><K><F><M><H><K><D><G><S><V><P><L><A><A><E><I><L><A><G><G><C><A><G><G><S><Q><V><I><F><T><N><P><L><E><I><V><K><I><R><L><Q><V><A><G><E><I><T><T><G><P><R><V><S><A><L><S><V><V><R><D><L><G><F><F><G><I><Y><K><G><A><K><A><C><F><L><R><D><I><P><F><S><A><I><Y><F><P><C><Y><A><H><V><K><A><S><F><A><N><E><D><G><Q><V><S><P><G><S><L><L><L><A><G><A><I><A><G><M><P><A><A><S><L><V><T><P><A><D><V><I><K><T><R><L><Q><V><A><A><R><A><G><Q><T><T><Y><S><G><V><I><D><C><F><R><K><I><L><R><E><E><G><P><K><A><L><W><K><G><A><G><A><R><V><F><R><S><S><P><Q><F><G><V><T><L><L><T><Y><E><L><L><Q><R><W><F><Y><I><D><F><G><G><V><K><P><M><G><S><E><P><V><P><K><S><R><I><N><L><P><A><P><N><P><D><H><V><G><G><Y><K><L><A><V><A><T><F><A><G><I><E><N><K><F><G><L><Y><L><P><L><F><K><P><S><V><S><T><S><K><A><I><G><G><G><P>
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle . Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation .<BOP>
Q9UJS0
Q96KW9
SPAC7_HUMAN
Sperm acrosome-associated protein 7
Homo
<M><A><V><S><Q><G><D><G><T><L><C><F><V><L><L><L><C><C><W><Q><E><T><E><L><R><P><R><T><V><I><P><G><S><P><T><E><I><P><F><S><S><K><Q><E><D><M><S><E><L><L><D><E><I><L><V><Q><E><I><L><D><L><N><K><T><T><P><S><E><M><P><S><T><A><S><T><L><S><T><P><L><H><A><G><I><D><E><N><Y><Q><A><G><G><S><E><N><Y><H><E><L><L><E><N><L><Q><F><S><P><G><I><E><V><K><I><S><N><D><E><A><N><A><N><A><N><L><H><G><D><P><S><E><N><Y><R><G><P><Q><V><S><P><G><S><E><K><S><V><S><S><K><E><K><N><S><K><N><T><Q><Y><E><N><L><S><I><L><D><Q><I><L><Q><N><I><G><R><S><S><G><N><I><F><H><K><E><Q><Q><R><T><S><A><Q><R><R><S><Q><G><S><Q>
Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.<BOP>
Q96KW9
Q8IWV1
LAX1_HUMAN
Membrane-associated adapter protein LAX
Homo
<M><D><G><V><T><P><T><L><S><T><I><R><G><R><T><L><E><S><S><T><L><H><V><T><P><R><S><L><D><R><N><K><D><Q><I><T><N><I><F><S><G><F><A><G><L><L><A><I><L><L><V><V><A><V><F><C><I><L><W><N><W><N><K><R><K><K><R><Q><V><P><Y><L><R><V><T><V><M><P><L><L><T><L><P><Q><T><R><Q><R><A><K><N><I><Y><D><I><L><P><W><R><Q><E><D><L><G><R><H><E><S><R><S><M><R><I><F><S><T><E><S><L><L><S><R><N><S><E><S><P><E><H><V><P><S><Q><A><G><N><A><F><Q><E><H><T><A><H><I><H><A><T><E><Y><A><V><G><I><Y><D><N><A><M><V><P><Q><M><C><G><N><L><T><P><S><A><H><C><I><N><V><R><A><S><R><D><C><A><S><I><S><S><E><D><S><H><D><Y><V><N><V><P><T><A><E><E><I><A><E><T><L><A><S><T><K><S><P><S><R><N><L><F><V><L><P><S><T><Q><K><L><E><F><T><E><E><R><D><E><G><C><G><D><A><G><D><C><T><S><L><Y><S><P><G><A><E><D><S><D><S><L><S><N><G><E><G><S><S><Q><I><S><N><D><Y><V><N><M><T><G><L><D><L><S><A><I><Q><E><R><Q><L><W><V><A><F><Q><C><C><R><D><Y><E><N><V><P><A><A><D><P><S><G><S><Q><Q><Q><A><E><K><D><V><P><S><S><N><I><G><H><V><E><D><K><T><D><D><P><G><T><H><V><Q><C><V><K><R><T><F><L><A><S><G><D><Y><A><D><F><Q><P><F><T><Q><S><E><D><S><Q><M><K><H><R><E><E><M><S><N><E><D><S><S><D><Y><E><N><V><L><T><A><K><L><G><G><R><D><S><E><Q><G><P><G><T><Q><L><L><P><D><E>
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.<BOP>
Q8IWV1
Q03924
ZN117_HUMAN
Zinc finger protein HPF9
Homo
<M><K><R><H><E><M><V><A><K><H><L><V><M><F><Y><Y><F><A><Q><H><L><W><P><E><Q><N><I><R><D><S><F><Q><K><V><T><L><R><R><Y><R><K><C><G><Y><E><N><L><Q><L><R><K><G><C><K><S><V><V><E><C><K><Q><H><K><G><D><Y><S><G><L><N><Q><C><L><K><T><T><L><S><K><I><F><Q><C><N><K><Y><V><E><V><F><H><K><I><S><N><S><N><R><H><K><M><R><H><T><E><N><K><H><F><K><C><K><E><C><R><K><T><F><C><M><L><S><H><L><T><Q><H><K><R><I><Q><T><R><V><N><F><Y><K><C><E><A><Y><G><R><A><F><N><W><S><S><T><L><N><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><N><Q><T><S><H><L><I><R><H><K><R><I><H><T><E><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><N><I><I><H><T><G><E><I><P><Y><K><C><E><K><C><V><R><A><F><N><Q><A><S><K><L><T><E><H><K><L><I><H><T><G><E><K><R><Y><E><C><E><E><C><G><K><A><F><N><R><S><S><K><L><T><E><H><K><Y><I><H><T><G><E><K><L><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><K><R><I><H><S><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><K><Q><F><S><N><L><T><D><H><K><K><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><L><S><N><L><T><R><H><K><V><I><H><T><G><E><K><P><Y><K><C><G><E><C><G><K><A><F><N><Q><S><S><A><L><N><T><H><K><I><I><H><T><G><E><N><P><H><K><C><R><E><S><G><K><V><F><H><L><S><S><K><L><S><T><C><K><K><I><H><T><G><E><K><L><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><T><L><I><G><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><T><L><T><T><H><K><I><I><H><T><E><E><K><Q><Y><K><C><D><E><C><G><K><A><S><T>
May be involved in transcriptional regulation.<BOP>
Q03924
O43187
IRAK2_HUMAN
Interleukin-1 receptor-associated kinase-like 2
Homo
<M><A><C><Y><I><Y><Q><L><P><S><W><V><L><D><D><L><C><R><N><M><D><A><L><S><E><W><D><W><M><E><F><A><S><Y><V><I><T><D><L><T><Q><L><R><K><I><K><S><M><E><R><V><Q><G><V><S><I><T><R><E><L><L><W><W><W><G><M><R><Q><A><T><V><Q><Q><L><V><D><L><L><C><R><L><E><L><Y><R><A><A><Q><I><I><L><N><W><K><P><A><P><E><I><R><C><P><I><P><A><F><P><D><S><V><K><P><E><K><P><L><A><A><S><V><R><K><A><E><D><E><Q><E><E><G><Q><P><V><R><M><A><T><F><P><G><P><G><S><S><P><A><R><A><H><Q><P><A><F><L><Q><P><P><E><E><D><A><P><H><S><L><R><S><D><L><P><T><S><S><D><S><K><D><F><S><T><S><I><P><K><Q><E><K><L><L><S><L><A><G><D><S><L><F><W><S><E><A><D><V><V><Q><A><T><D><D><F><N><Q><N><R><K><I><S><Q><G><T><F><A><D><V><Y><R><G><H><R><H><G><K><P><F><V><F><K><K><L><R><E><T><A><C><S><S><P><G><S><I><E><R><F><F><Q><A><E><L><Q><I><C><L><R><C><C><H><P><N><V><L><P><V><L><G><F><C><A><A><R><Q><F><H><S><F><I><Y><P><Y><M><A><N><G><S><L><Q><D><R><L><Q><G><Q><G><G><S><D><P><L><P><W><P><Q><R><V><S><I><C><S><G><L><L><C><A><V><E><Y><L><H><G><L><E><I><I><H><S><N><V><K><S><S><N><V><L><L><D><Q><N><L><T><P><K><L><A><H><P><M><A><H><L><C><P><V><N><K><R><S><K><Y><T><M><M><K><T><H><L><L><R><T><S><A><A><Y><L><P><E><D><F><I><R><V><G><Q><L><T><K><R><V><D><I><F><S><C><G><I><V><L><A><E><V><L><T><G><I><P><A><M><D><N><N><R><S><P><V><Y><L><K><D><L><L><L><S><D><I><P><S><S><T><A><S><L><C><S><R><K><T><G><V><E><N><V><M><A><K><E><I><C><Q><K><Y><L><E><K><G><A><G><R><L><P><E><D><C><A><E><A><L><A><T><A><A><C><L><C><L><R><R><R><N><T><S><L><Q><E><V><C><G><S><V><A><A><V><E><E><R><L><R><G><R><E><T><L><L><P><W><S><G><L><S><E><G><T><G><S><S><S><N><T><P><E><E><T><D><D><V><D><N><S><S><L><D><A><S><S><S><M><S><V><A><P><W><A><G><A><A><T><P><L><L><P><T><E><N><G><E><G><R><L><R><V><I><V><G><R><E><A><D><S><S><S><E><A><C><V><G><L><E><P><P><Q><D><V><T><E><T><S><W><Q><I><E><I><N><E><A><K><R><K><L><M><E><N><I><L><L><Y><K><E><E><K><V><D><S><I><E><L><F><G><P>
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.<BOP>
O43187
Q9BRB3
PIGQ_HUMAN
Phosphatidylinositol-glycan biosynthesis class Q protein
Homo
<M><V><L><K><A><F><F><P><T><C><C><V><S><T><D><S><G><L><L><V><G><R><W><V><P><E><Q><S><S><A><V><V><L><A><V><L><H><F><P><F><I><P><I><Q><V><K><Q><L><L><A><Q><V><R><Q><A><S><Q><V><G><V><A><V><L><G><T><W><C><H><C><R><Q><E><P><E><E><S><L><G><R><F><L><E><S><L><G><A><V><F><P><H><E><P><W><L><R><L><C><R><E><R><G><G><T><F><W><S><C><E><A><T><H><R><Q><A><P><T><A><P><G><A><P><G><E><D><Q><V><M><L><I><F><Y><D><Q><R><Q><V><L><L><S><Q><L><H><L><P><T><V><L><P><D><R><Q><A><G><A><T><T><A><S><T><G><G><L><A><A><V><F><D><T><V><A><R><S><E><V><L><F><R><S><D><R><F><D><E><G><P><V><R><L><S><H><W><Q><S><E><G><V><E><A><S><I><L><A><E><L><A><R><R><A><S><G><P><I><C><L><L><L><A><S><L><L><S><L><V><S><A><V><S><A><C><R><V><F><K><L><W><P><L><S><F><L><G><S><K><L><S><T><C><E><Q><L><R><H><R><L><E><H><L><T><L><I><F><S><T><R><K><A><E><N><P><A><Q><L><M><R><K><A><N><T><V><A><S><V><L><L><D><V><A><L><G><L><M><L><L><S><W><L><H><G><R><S><R><I><G><H><L><A><D><A><L><V><P><V><A><D><H><V><A><E><E><L><Q><H><L><L><Q><W><L><M><G><A><P><A><G><L><K><M><N><R><A><L><D><Q><V><L><G><R><F><F><L><Y><H><I><H><L><W><I><S><Y><I><H><L><M><S><P><F><V><E><H><I><L><W><H><V><G><L><S><A><C><L><G><L><T><V><A><L><S><L><L><S><D><I><I><A><L><L><T><F><H><I><Y><C><F><Y><V><Y><G><A><R><L><Y><C><L><K><I><H><G><L><S><S><L><W><R><L><F><R><G><K><K><W><N><V><L><R><Q><R><V><D><S><C><S><Y><D><L><D><Q><L><F><I><G><T><L><L><F><T><I><L><L><F><L><L><P><T><T><A><L><Y><Y><L><V><F><T><L><L><R><L><L><V><V><A><V><Q><G><L><I><H><L><L><V><D><L><I><N><S><L><P><L><Y><S><L><G><L><R><L><C><R><P><Y><R><L><A><D><K><P><T><A><L><Q><P><R><G><A><H><L><P><P><P><Q><L><W><L><P><P><Q><A><L><L><G><R><P><V><P><Q><A><V><P><W><G><A><H><L><P><L><E><A><E><R><G><Q><A><G><L><R><E><L><L><A><R><L><A><P><P><H><G><H><S><Q><P><S><A><L><P><G><W><H><Q><L><S><W><R><M><S><C><A><L><W><T><L><L><C><A><P><E><H><G><R><P><C><Y><H><T><L><G><L><E><V><I><G><S><E><Q><M><W><G><W><P><A><R><L><A><A><L><H><H><W><H><C><L><P><W><D><P><L><P><T><C><C><G><H><H><G><G><E><H><S><N><P><R><C><P><E><H><C><P><M><P><T><L><C><T><Q><V><Q><R><V><R><P><P><Q><Q><P><Q><V><E><G><W><S><P><W><G><L><P><S><G><S><A><L><A><V><G><V><E><G><P><C><Q><D><E><P><P><S><P><R><H><P><L><A><P><S><A><E><Q><H><P><A><S><G><G><L><K><Q><S><L><T><P><V><P><S><G><P><G><P><S><L><P><E><P><H><G><V><Y><L><R><M><F><P><G><E><V><A><L>
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP>
Q9BRB3
O43927
CXL13_HUMAN
Small-inducible cytokine B13
Homo
<M><K><F><I><S><T><S><L><L><L><M><L><L><V><S><S><L><S><P><V><Q><G><V><L><E><V><Y><Y><T><S><L><R><C><R><C><V><Q><E><S><S><V><F><I><P><R><R><F><I><D><R><I><Q><I><L><P><R><G><N><G><C><P><R><K><E><I><I><V><W><K><K><N><K><S><I><V><C><V><D><P><Q><A><E><W><I><Q><R><M><M><E><V><L><R><K><R><S><S><S><T><L><P><V><P><V><F><K><R><K><I><P>
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.<BOP>
O43927
O15305
PMM2_HUMAN
Phosphomannomutase 2
Homo
<M><A><A><P><G><P><A><L><C><L><F><D><V><D><G><T><L><T><A><P><R><Q><K><I><T><K><E><M><D><D><F><L><Q><K><L><R><Q><K><I><K><I><G><V><V><G><G><S><D><F><E><K><V><Q><E><Q><L><G><N><D><V><V><E><K><Y><D><Y><V><F><P><E><N><G><L><V><A><Y><K><D><G><K><L><L><C><R><Q><N><I><Q><S><H><L><G><E><A><L><I><Q><D><L><I><N><Y><C><L><S><Y><I><A><K><I><K><L><P><K><K><R><G><T><F><I><E><F><R><N><G><M><L><N><V><S><P><I><G><R><S><C><S><Q><E><E><R><I><E><F><Y><E><L><D><K><K><E><N><I><R><Q><K><F><V><A><D><L><R><K><E><F><A><G><K><G><L><T><F><S><I><G><G><Q><I><S><F><D><V><F><P><D><G><W><D><K><R><Y><C><L><R><H><V><E><N><D><G><Y><K><T><I><Y><F><F><G><D><K><T><M><P><G><G><N><D><H><E><I><F><T><D><P><R><T><M><G><Y><S><V><T><A><P><E><D><T><R><R><I><C><E><L><L><F><S>
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.<BOP>
O15305
P23381
SYWC_HUMAN
T2-TrpRS
Homo
<M><P><N><S><E><P><A><S><L><L><E><L><F><N><S><I><A><T><Q><G><E><L><V><R><S><L><K><A><G><N><A><S><K><D><E><I><D><S><A><V><K><M><L><V><S><L><K><M><S><Y><K><A><A><A><G><E><D><Y><K><A><D><C><P><P><G><N><P><A><P><T><S><N><H><G><P><D><A><T><E><A><E><E><D><F><V><D><P><W><T><V><Q><T><S><S><A><K><G><I><D><Y><D><K><L><I><V><R><F><G><S><S><K><I><D><K><E><L><I><N><R><I><E><R><A><T><G><Q><R><P><H><H><F><L><R><R><G><I><F><F><S><H><R><D><M><N><Q><V><L><D><A><Y><E><N><K><K><P><F><Y><L><Y><T><G><R><G><P><S><S><E><A><M><H><V><G><H><L><I><P><F><I><F><T><K><W><L><Q><D><V><F><N><V><P><L><V><I><Q><M><T><D><D><E><K><Y><L><W><K><D><L><T><L><D><Q><A><Y><S><Y><A><V><E><N><A><K><D><I><I><A><C><G><F><D><I><N><K><T><F><I><F><S><D><L><D><Y><M><G><M><S><S><G><F><Y><K><N><V><V><K><I><Q><K><H><V><T><F><N><Q><V><K><G><I><F><G><F><T><D><S><D><C><I><G><K><I><S><F><P><A><I><Q><A><A><P><S><F><S><N><S><F><P><Q><I><F><R><D><R><T><D><I><Q><C><L><I><P><C><A><I><D><Q><D><P><Y><F><R><M><T><R><D><V><A><P><R><I><G><Y><P><K><P><A><L><L><H><S><T><F><F><P><A><L><Q><G><A><Q><T><K><M><S><A><S><D><P><N><S><S><I><F><L><T><D><T><A><K><Q><I><K><T><K><V><N><K><H><A><F><S><G><G><R><D><T><I><E><E><H><R><Q><F><G><G><N><C><D><V><D><V><S><F><M><Y><L><T><F><F><L><E><D><D><D><K><L><E><Q><I><R><K><D><Y><T><S><G><A><M><L><T><G><E><L><K><K><A><L><I><E><V><L><Q><P><L><I><A><E><H><Q><A><R><R><K><E><V><T><D><E><I><V><K><E><F><M><T><P><R><K><L><S><F><D><F><Q>
Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.<BOP>
P23381
O15144
ARPC2_HUMAN
Arp2/3 complex 34 kDa subunit
Homo
<M><I><L><L><E><V><N><N><R><I><I><E><E><T><L><A><L><K><F><E><N><A><A><A><G><N><K><P><E><A><V><E><V><T><F><A><D><F><D><G><V><L><Y><H><I><S><N><P><N><G><D><K><T><K><V><M><V><S><I><S><L><K><F><Y><K><E><L><Q><A><H><G><A><D><E><L><L><K><R><V><Y><G><S><F><L><V><N><P><E><S><G><Y><N><V><S><L><L><Y><D><L><E><N><L><P><A><S><K><D><S><I><V><H><Q><A><G><M><L><K><R><N><C><F><A><S><V><F><E><K><Y><F><Q><F><Q><E><E><G><K><E><G><E><N><R><A><V><I><H><Y><R><D><D><E><T><M><Y><V><E><S><K><K><D><R><V><T><V><V><F><S><T><V><F><K><D><D><D><D><V><V><I><G><K><V><F><M><Q><E><F><K><E><G><R><R><A><S><H><T><A><P><Q><V><L><F><S><H><R><E><P><P><L><E><L><K><D><T><D><A><A><V><G><D><N><I><G><Y><I><T><F><V><L><F><P><R><H><T><N><A><S><A><R><D><N><T><I><N><L><I><H><T><F><R><D><Y><L><H><Y><H><I><K><C><S><K><A><Y><I><H><T><R><M><R><A><K><T><S><D><F><L><K><V><L><N><R><A><R><P><D><A><E><K><K><E><M><K><T><I><T><G><K><T><F><S><S><R>
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the mother actin filament . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .<BOP>
O15144
Q13123
RED_HUMAN
Protein RER
Homo
<M><P><E><R><D><S><E><P><F><S><N><P><L><A><P><D><G><H><D><V><D><D><P><H><S><F><H><Q><S><K><L><T><N><E><D><F><R><K><L><L><M><T><P><R><A><A><P><T><S><A><P><P><S><K><S><R><H><H><E><M><P><R><E><Y><N><E><D><E><D><P><A><A><R><R><R><K><K><K><S><Y><Y><A><K><L><R><Q><Q><E><I><E><R><E><R><E><L><A><E><K><Y><R><D><R><A><K><E><R><R><D><G><V><N><K><D><Y><E><E><T><E><L><I><S><T><T><A><N><Y><R><A><V><G><P><T><A><E><A><D><K><S><A><A><E><K><R><R><Q><L><I><Q><E><S><K><F><L><G><G><D><M><E><H><T><H><L><V><K><G><L><D><F><A><L><L><Q><K><V><R><A><E><I><A><S><K><E><K><E><E><E><E><L><M><E><K><P><Q><K><E><T><K><K><D><E><D><P><E><N><K><I><E><F><K><T><R><L><G><R><N><V><Y><R><M><L><F><K><S><K><A><Y><E><R><N><E><L><F><L><P><G><R><M><A><Y><V><V><D><L><D><D><E><Y><A><D><T><D><I><P><T><T><L><I><R><S><K><A><D><C><P><T><M><E><A><Q><T><T><L><T><T><N><D><I><V><I><S><K><L><T><Q><I><L><S><Y><L><R><Q><G><T><R><N><K><K><L><K><K><K><D><K><G><K><L><E><E><K><K><P><P><E><A><D><M><N><I><F><E><D><I><G><D><Y><V><P><S><T><T><K><T><P><R><D><K><E><R><E><R><Y><R><E><R><E><R><D><R><E><R><D><R><D><R><D><R><E><R><E><R><E><R><D><R><E><R><E><R><E><R><D><R><E><R><E><E><E><K><K><R><H><S><Y><F><E><K><P><K><V><D><D><E><P><M><D><V><D><K><G><P><G><S><T><K><E><L><I><K><S><I><N><E><K><F><A><G><S><A><G><W><E><G><T><E><S><L><K><K><P><E><D><K><K><Q><L><G><D><F><F><G><M><S><N><S><Y><A><E><C><Y><P><A><T><M><D><D><M><A><V><D><S><D><E><E><V><D><Y><S><K><M><D><Q><G><N><K><K><G><P><L><G><R><W><D><F><D><T><Q><E><E><Y><S><E><Y><M><N><N><K><E><A><L><P><K><A><A><F><Q><Y><G><I><K><M><S><E><G><R><K><T><R><R><F><K><E><T><N><D><K><A><E><L><D><R><Q><W><K><K><I><S><A><I><I><E><K><R><K><K><M><E><A><D><G><V><E><V><K><R><P><K><Y>
(Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.<BOP>
Q13123
Q5VX71
SUSD4_HUMAN
Sushi domain-containing protein 4
Homo
<M><Y><H><G><M><N><P><S><N><G><D><G><F><L><E><Q><Q><Q><Q><Q><Q><Q><P><Q><S><P><Q><R><L><L><A><V><I><L><W><F><Q><L><A><L><C><F><G><P><A><Q><L><T><G><G><F><D><D><L><Q><V><C><A><D><P><G><I><P><E><N><G><F><R><T><P><S><G><G><V><F><F><E><G><S><V><A><R><F><H><C><Q><D><G><F><K><L><K><G><A><T><K><R><L><C><L><K><H><F><N><G><T><L><G><W><I><P><S><D><N><S><I><C><V><Q><E><D><C><R><I><P><Q><I><E><D><A><E><I><H><N><K><T><Y><R><H><G><E><K><L><I><I><T><C><H><E><G><F><K><I><R><Y><P><D><L><H><N><M><V><S><L><C><R><D><D><G><T><W><N><N><L><P><I><C><Q><G><C><L><R><P><L><A><S><S><N><G><Y><V><N><I><S><E><L><Q><T><S><F><P><V><G><T><V><I><S><Y><R><C><F><P><G><F><K><L><D><G><S><A><Y><L><E><C><L><Q><N><L><I><W><S><S><S><P><P><R><C><L><A><L><E><V><C><P><L><P><P><M><V><S><H><G><D><F><V><C><H><P><R><P><C><E><R><Y><N><H><G><T><V><V><E><F><Y><C><D><P><G><Y><S><L><T><S><D><Y><K><Y><I><T><C><Q><Y><G><E><W><F><P><S><Y><Q><V><Y><C><I><K><S><E><Q><T><W><P><S><T><H><E><T><L><L><T><T><W><K><I><V><A><F><T><A><T><S><V><L><L><V><L><L><L><V><I><L><A><R><M><F><Q><T><K><F><K><A><H><F><P><P><R><G><P><P><R><S><S><S><S><D><P><D><F><V><V><V><D><G><V><P><V><M><L><P><S><Y><D><E><A><V><S><G><G><L><S><A><L><G><P><G><Y><M><A><S><V><G><Q><G><C><P><L><P><V><D><D><Q><S><P><P><A><Y><P><G><S><G><D><T><D><T><G><P><G><E><S><E><T><C><D><S><V><S><G><S><S><E><L><L><Q><S><L><Y><S><P><P><R><C><Q><E><S><T><H><P><A><S><D><N><P><D><I><I><A><S><T><A><E><E><V><A><S><T><S><P><G><I><D><I><A><D><E><I><P><L><M><E><E><D><P>
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.<BOP>
Q5VX71
O95202
LETM1_HUMAN
Leucine zipper-EF-hand-containing transmembrane protein 1
Homo
<M><A><S><I><L><L><R><S><C><R><G><R><A><P><A><R><L><P><P><P><P><R><Y><T><V><P><R><G><S><P><G><D><P><A><H><L><S><C><A><S><T><L><G><L><R><N><C><L><N><V><P><F><G><C><C><T><P><I><H><P><V><Y><T><S><S><R><G><D><H><L><G><C><W><A><L><R><P><E><C><L><R><I><V><S><R><A><P><W><T><S><T><S><V><G><F><V><A><V><G><P><Q><C><L><P><V><R><G><W><H><S><S><R><P><V><R><D><D><S><V><V><E><K><S><L><K><S><L><K><D><K><N><K><K><L><E><E><G><G><P><V><Y><S><P><P><A><E><V><V><V><K><K><S><L><G><Q><R><V><L><D><E><L><K><H><Y><Y><H><G><F><R><L><L><W><I><D><T><K><I><A><A><R><M><L><W><R><I><L><N><G><H><S><L><T><R><R><E><R><R><Q><F><L><R><I><C><A><D><L><F><R><L><V><P><F><L><V><F><V><V><V><P><F><M><E><F><L><L><P><V><A><V><K><L><F><P><N><M><L><P><S><T><F><E><T><Q><S><L><K><E><E><R><L><K><K><E><L><R><V><K><L><E><L><A><K><F><L><Q><D><T><I><E><E><M><A><L><K><N><K><A><A><K><G><S><A><T><K><D><F><S><V><F><F><Q><K><I><R><E><T><G><E><R><P><S><N><E><E><I><M><R><F><S><K><L><F><E><D><E><L><T><L><D><N><L><T><R><P><Q><L><V><A><L><C><K><L><L><E><L><Q><S><I><G><T><N><N><F><L><R><F><Q><L><T><M><R><L><R><S><I><K><A><D><D><K><L><I><A><E><E><G><V><D><S><L><N><V><K><E><L><Q><A><A><C><R><A><R><G><M><R><A><L><G><V><T><E><D><R><L><R><G><Q><L><K><Q><W><L><D><L><H><L><H><Q><E><I><P><T><S><L><L><I><L><S><R><A><M><Y><L><P><D><T><L><S><P><A><D><Q><L><K><S><T><L><Q><T><L><P><E><I><V><A><K><E><A><Q><V><K><V><A><E><V><E><G><E><Q><V><D><N><K><A><K><L><E><A><T><L><Q><E><E><A><A><I><Q><Q><E><H><R><E><K><E><L><Q><K><R><S><E><V><A><K><D><F><E><P><E><R><V><V><A><A><P><Q><R><P><G><T><E><P><Q><P><E><M><P><D><T><V><L><Q><S><E><T><L><K><D><T><A><P><V><L><E><G><L><K><E><E><E><I><T><K><E><E><I><D><I><L><S><D><A><C><S><K><L><Q><E><Q><K><K><S><L><T><K><E><K><E><E><L><E><L><L><K><E><D><V><Q><D><Y><S><E><D><L><Q><E><I><K><K><E><L><S><K><T><G><E><E><K><Y><V><E><E><S><K><A><S><K><R><L><T><K><R><V><Q><Q><M><I><G><Q><I><D><G><L><I><S><Q><L><E><M><D><Q><Q><A><G><K><L><A><P><A><N><G><M><P><T><G><E><N><V><I><S><V><A><E><L><I><N><A><M><K><Q><V><K><H><I><P><E><S><K><L><T><S><L><A><A><A><L><D><E><N><K><D><G><K><V><N><I><D><D><L><V><K><V><I><E><L><V><D><K><E><D><V><H><I><S><T><S><Q><V><A><E><I><V><A><T><L><E><K><E><E><K><V><E><E><K><E><K><A><K><E><K><A><E><K><E><V><A><E><V><K><S>
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion . Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain . Required for the maintenance of the tubular shape and cristae organization . In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion .<BOP>
O95202
Q9Y6I7
WSB1_HUMAN
SOCS box-containing WD protein SWiP-1
Homo
<M><A><S><F><P><P><R><V><N><E><K><E><I><V><R><L><R><T><I><G><E><L><L><A><P><A><A><P><F><D><K><K><C><G><R><E><N><W><T><V><A><F><A><P><D><G><S><Y><F><A><W><S><Q><G><H><R><T><V><K><L><V><P><W><S><Q><C><L><Q><N><F><L><L><H><G><T><K><N><V><T><N><S><S><S><L><R><L><P><R><Q><N><S><D><G><G><Q><K><N><K><P><R><E><H><I><I><D><C><G><D><I><V><W><S><L><A><F><G><S><S><V><P><E><K><Q><S><R><C><V><N><I><E><W><H><R><F><R><F><G><Q><D><Q><L><L><L><A><T><G><L><N><N><G><R><I><K><I><W><D><V><Y><T><G><K><L><L><L><N><L><V><D><H><T><E><V><V><R><D><L><T><F><A><P><D><G><S><L><I><L><V><S><A><S><R><D><K><T><L><R><V><W><D><L><K><D><D><G><N><M><M><K><V><L><R><G><H><Q><N><W><V><Y><S><C><A><F><S><P><D><S><S><M><L><C><S><V><G><A><S><K><A><V><F><L><W><N><M><D><K><Y><T><M><I><R><K><L><E><G><H><H><H><D><V><V><A><C><D><F><S><P><D><G><A><L><L><A><T><A><S><Y><D><T><R><V><Y><I><W><D><P><H><N><G><D><I><L><M><E><F><G><H><L><F><P><P><P><T><P><I><F><A><G><G><A><N><D><R><W><V><R><S><V><S><F><S><H><D><G><L><H><V><A><S><L><A><D><D><K><M><V><R><F><W><R><I><D><E><D><Y><P><V><Q><V><A><P><L><S><N><G><L><C><C><A><F><S><T><D><G><S><V><L><A><A><G><T><H><D><G><S><V><Y><F><W><A><T><P><R><Q><V><P><S><L><Q><H><L><C><R><M><S><I><R><R><V><M><P><T><Q><E><V><Q><E><L><P><I><P><S><K><L><L><E><F><L><S><Y><R><I>
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.<BOP>
Q9Y6I7
Q9NWX6
THG1_HUMAN
tRNA-histidine guanylyltransferase
Homo
<M><W><G><A><C><K><V><K><V><H><D><S><L><A><T><I><S><I><T><L><R><R><Y><L><R><L><G><A><T><M><A><K><S><K><F><E><Y><V><R><D><F><E><A><D><D><T><C><L><A><H><C><W><V><V><V><R><L><D><G><R><N><F><H><R><F><A><E><K><H><N><F><A><K><P><N><D><S><R><A><L><Q><L><M><T><K><C><A><Q><T><V><M><E><E><L><E><D><I><V><I><A><Y><G><Q><S><D><E><Y><S><F><V><F><K><R><K><T><N><W><F><K><R><R><A><S><K><F><M><T><H><V><A><S><Q><F><A><S><S><Y><V><F><Y><W><R><D><Y><F><E><D><Q><P><L><L><Y><P><P><G><F><D><G><R><V><V><V><Y><P><S><N><Q><T><L><K><D><Y><L><S><W><R><Q><A><D><C><H><I><N><N><L><Y><N><T><V><F><W><A><L><I><Q><Q><S><G><L><T><P><V><Q><A><Q><G><R><L><Q><G><T><L><A><A><D><K><N><E><I><L><F><S><E><F><N><I><N><Y><N><N><E><L><P><M><Y><R><K><G><T><V><L><I><W><Q><K><V><D><E><V><M><T><K><E><I><K><L><P><T><E><M><E><G><K><K><M><A><V><T><R><T><R><T><K><P><V><P><L><H><C><D><I><I><G><D><A><F><W><K><E><H><P><E><I><L><D><E><D><S>
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion . By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress .<BOP>
Q9NWX6
P04437
TVA29_HUMAN
T cell receptor alpha variable 29/delta variable 5
Homo
<M><A><M><L><L><G><A><S><V><L><I><L><W><L><Q><P><D><W><V><N><S><Q><Q><K><N><D><D><Q><Q><V><K><Q><N><S><P><S><L><S><V><Q><E><G><R><I><S><I><L><N><C><D><Y><T><N><S><M><F><D><Y><F><L><W><Y><K><K><Y><P><A><E><G><P><T><F><L><I><S><I><S><S><I><K><D><K><N><E><D><G><R><F><T><V><F><L><N><K><S><A><K><H><L><S><L><H><I><V><P><S><Q><P><G><D><S><A><V><Y><F><C><A><A><S>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
P04437
Q8NCW0
KREM2_HUMAN
Kringle-containing protein marking the eye and the nose
Homo
<M><G><T><Q><A><L><Q><G><F><L><F><L><L><F><L><P><L><L><Q><P><R><G><A><S><A><G><S><L><H><S><P><G><L><S><E><C><F><Q><V><N><G><A><D><Y><R><G><H><Q><N><R><T><G><P><R><G><A><G><R><P><C><L><F><W><D><Q><T><Q><Q><H><S><Y><S><S><A><S><D><P><H><G><R><W><G><L><G><A><H><N><F><C><R><N><P><D><G><D><V><Q><P><W><C><Y><V><A><E><T><E><E><G><I><Y><W><R><Y><C><D><I><P><S><C><H><M><P><G><Y><L><G><C><F><V><D><S><G><A><P><P><A><L><S><G><P><S><G><T><S><T><K><L><T><V><Q><V><C><L><R><F><C><R><M><K><G><Y><Q><L><A><G><V><E><A><G><Y><A><C><F><C><G><S><E><S><D><L><A><R><G><R><L><A><P><A><T><D><C><D><Q><I><C><F><G><H><P><G><Q><L><C><G><G><D><G><R><L><G><V><Y><E><V><S><V><G><S><C><Q><G><N><W><T><A><P><Q><G><V><I><Y><S><P><D><F><P><D><E><Y><G><P><D><R><N><C><S><W><A><L><G><P><P><G><A><A><L><E><L><T><F><R><L><F><E><L><A><D><P><R><D><R><L><E><L><R><D><A><A><S><G><S><L><L><R><A><F><D><G><A><R><P><P><P><S><G><P><L><R><L><G><T><A><A><L><L><L><T><F><R><S><D><A><R><G><H><A><Q><G><F><A><L><T><Y><R><G><L><Q><D><A><A><E><D><P><E><A><P><E><G><S><A><Q><T><P><A><A><P><L><D><G><A><N><V><S><C><S><P><R><P><G><A><P><P><A><A><I><G><A><R><V><F><S><T><V><T><A><V><S><V><L><L><L><L><L><L><G><L><L><R><P><L><R><R><R><S><C><L><L><A><P><G><K><G><P><P><A><L><G><A><S><R><G><P><R><R><S><W><A><V><W><Y><Q><Q><P><R><G><V><A><L><P><C><S><P><G><D><P><Q><A><E><G><S><A><A><G><Y><R><P><L><S><A><S><S><Q><S><S><L><R><S><L><I><S><A><L>
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.<BOP>
Q8NCW0
Q8WTX9
ZDHC1_HUMAN
Zinc finger protein 377
Homo
<M><Y><K><M><N><I><C><N><K><P><S><N><K><T><A><P><E><K><S><V><W><T><A><P><A><Q><P><S><G><P><S><P><E><L><Q><G><Q><R><S><R><R><N><G><W><S><W><P><P><H><P><L><Q><I><V><A><W><L><L><Y><L><F><F><A><V><I><G><F><G><I><L><V><P><L><L><P><H><H><W><V><P><A><G><Y><A><C><M><G><A><I><F><A><G><H><L><V><V><H><L><T><A><V><S><I><D><P><A><D><A><N><V><R><D><K><S><Y><A><G><P><L><P><I><F><N><R><S><Q><H><A><H><V><I><E><D><L><H><C><N><L><C><N><V><D><V><S><A><R><S><K><H><C><S><A><C><N><K><C><V><C><G><F><D><H><H><C><K><W><L><N><N><C><V><G><E><R><N><Y><R><L><F><L><H><S><V><A><S><A><L><L><G><V><L><L><L><V><L><V><A><T><Y><V><F><V><E><F><F><V><N><P><M><R><L><R><T><N><R><H><F><E><V><L><K><N><H><T><D><V><W><F><V><F><L><P><A><A><P><V><E><T><Q><A><P><A><I><L><A><L><A><A><L><L><I><L><L><G><L><L><S><T><A><L><L><G><H><L><L><C><F><H><I><Y><L><M><W><H><K><L><T><T><Y><E><Y><I><V><Q><H><R><P><P><Q><E><A><K><G><V><H><R><E><L><E><S><C><P><P><K><M><R><P><I><Q><E><M><E><F><Y><M><R><T><F><R><H><M><R><P><E><P><P><G><Q><A><G><P><A><A><V><N><A><K><H><S><R><P><A><S><P><D><P><T><P><G><R><R><D><C><A><G><P><P><V><Q><V><E><W><D><R><K><K><P><L><P><W><R><S><P><L><L><L><L><A><M><W><G><P><Q><A><P><P><C><L><C><R><K><R><G><R><G><A><C><I><K><C><E><R><L><R><P><R><I><R><R><R><G><L><G><P><P><A><A><A><P><A><R><R><R><I><P><R><T><P><A><L><C><T><P><L><A><L><P><A><P><T><T><R><R><R><Q><S><P><W><T><R><F><Q><W><R><R><R><A><W><A><A><P><L><W><P><P><R><G><A><G><A><D><S><P><R><W><R><G><R><R><V><R><P><P><F><S>
Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response . Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components .<BOP>
Q8WTX9
O95721
SNP29_HUMAN
Vesicle-membrane fusion protein SNAP-29
Homo
<M><S><A><Y><P><K><S><Y><N><P><F><D><D><D><G><E><D><E><G><A><R><P><A><P><W><R><D><A><R><D><L><P><D><G><P><D><A><P><A><D><R><Q><Q><Y><L><R><Q><E><V><L><R><R><A><E><A><T><A><A><S><T><S><R><S><L><A><L><M><Y><E><S><E><K><V><G><V><A><S><S><E><E><L><A><R><Q><R><G><V><L><E><R><T><E><K><M><V><D><K><M><D><Q><D><L><K><I><S><Q><K><H><I><N><S><I><K><S><V><F><G><G><L><V><N><Y><F><K><S><K><P><V><E><T><P><P><E><Q><N><G><T><L><T><S><Q><P><N><N><R><L><K><E><A><I><S><T><S><K><E><Q><E><A><K><Y><Q><A><S><H><P><N><L><R><K><L><D><D><T><D><P><V><P><R><G><A><G><S><A><M><S><T><D><A><Y><P><K><N><P><H><L><R><A><Y><H><Q><K><I><D><S><N><L><D><E><L><S><M><G><L><G><R><L><K><D><I><A><L><G><M><Q><T><E><I><E><E><Q><D><D><I><L><D><R><L><T><T><K><V><D><K><L><D><V><N><I><K><S><T><E><R><K><V><R><Q><L>
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.<BOP>
O95721
Q9H3Q1
BORG4_HUMAN
Binder of Rho GTPases 4
Homo
<M><P><I><L><K><Q><L><V><S><S><S><V><H><S><K><R><R><S><R><A><D><L><T><A><E><M><I><S><A><P><L><G><D><F><R><H><T><M><H><V><G><R><A><G><D><A><F><G><D><T><S><F><L><N><S><K><A><G><E><P><D><G><E><S><L><D><E><Q><P><S><S><S><S><S><K><R><S><L><L><S><R><K><F><R><G><S><K><R><S><Q><S><V><T><R><G><E><R><E><Q><R><D><M><L><G><S><L><R><D><S><A><L><F><V><K><N><A><M><S><L><P><Q><L><N><E><K><E><A><A><E><K><G><T><S><K><L><P><K><S><L><S><S><S><P><V><K><K><A><N><D><G><E><G><G><D><E><E><A><G><T><E><E><A><V><P><R><R><N><G><A><A><G><P><H><S><P><D><P><L><L><D><E><Q><A><F><G><D><L><T><D><L><P><V><V><P><K><A><T><Y><G><L><K><H><A><E><S><I><M><S><F><H><I><D><L><G><P><S><M><L><G><D><V><L><S><I><M><D><K><E><E><W><D><P><E><E><G><E><G><G><Y><H><G><D><E><G><A><A><G><T><I><T><Q><A><P><P><Y><A><V><A><A><P><P><L><A><R><Q><E><G><K><A><G><P><D><L><P><S><L><P><S><H><A><L><E><D><E><G><W><A><A><A><A><P><S><P><G><S><A><R><S><M><G><S><H><T><T><R><D><S><S><S><L><S><S><C><T><S><G><I><L><E><E><R><S><P><A><F><R><G><P><D><R><A><R><A><A><V><S><R><Q><P><D><K><E><F><S><F><M><D><E><E><E><E><D><E><I><R><V>
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.<BOP>
Q9H3Q1
Q6NSI8
SANBR_HUMAN
SANT and BTB domain regulator of class switch recombination
Homo
<M><S><R><G><Y><S><E><N><N><N><F><L><N><N><N><N><Q><M><V><L><D><M><I><L><Y><P><L><I><G><I><P><Q><T><I><N><W><E><T><I><A><R><L><V><P><G><L><T><P><K><E><C><A><K><R><F><D><E><L><K><S><S><G><S><S><P><V><D><N><Q><Y><N><S><L><M><A><A><G><E><S><P><V><E><T><L><A><T><Y><I><K><S><S><L><L><D><I><H><G><E><F><Q><E><T><P><V><G><H><D><A><V><S><K><T><G><R><H><S><I><A><S><T><R><N><C><S><S><E><S><E><N><C><T><T><H><N><G><G><E><M><T><E><E><S><E><G><P><N><M><V><I><H><V><C><D><E><A><K><N><L><K><E><D><F><T><C><P><R><D><L><L><I><S><E><M><K><Y><F><A><E><Y><L><S><M><D><A><Q><R><W><E><E><V><D><I><S><V><H><C><D><V><H><I><F><N><W><L><I><K><Y><I><K><R><N><T><K><E><N><K><D><C><E><M><P><T><L><E><P><G><N><V><I><S><I><L><I><S><S><E><F><L><K><M><D><S><L><V><E><Q><C><I><Q><Y><C><H><K><N><M><N><A><I><V><A><T><P><C><N><M><N><C><I><N><A><N><L><L><T><R><I><A><D><L><F><S><H><N><E><V><D><D><L><K><D><K><K><D><K><F><K><S><K><L><F><C><K><K><I><E><R><L><F><D><P><E><Y><L><N><P><D><S><R><S><N><A><A><T><L><Y><R><C><C><L><C><K><K><L><L><T><K><E><T><E><R><R><I><P><C><I><P><G><K><I><N><V><D><R><R><G><N><I><V><Y><I><H><I><R><D><K><T><W><D><V><H><E><Y><L><N><S><L><F><E><E><L><K><S><W><R><D><V><Y><W><R><L><W><G><T><I><N><W><L><T><C><S><R><C><Y><Q><A><F><L><C><I><E><F><S><H><C><Q><Y><H><S><E><T><V><V><Y><P><T><A><A><S><S><L><N><T><V><G><T><G><I><Y><P><C><C><N><Q><K><V><L><R><F><D><P><T><Q><L><T><K><G><C><K><V><R><D><H><M><V><T><L><R><D><Q><G><E><G><G><D><L><P><S><C><P><T><A><R><M><L><D><D><L><H><K><Y><R><D><V><I><V><V><P><F><S><K><D><T><V><S><D><V><G><V><G><L><C><D><E><K><G><I><E><C><D><V><L><L><E><P><N><T><P><W><G><P><K><T><G><E><L><N><A><F><L><S><L><K><N><W><T><L><Q><L><K><Q><Q><S><L><F><S><E><E><E><E><Y><T><T><G><S><E><V><T><E><D><E><V><G><D><E><E><E><V><S><K><K><Q><R><K><K><E><K><P><K><K><F><T><R><Q><P><K><K><Q><V><S><S><P><C><A><Q><R><K><E><K><A><L><E><K><S><A><S><R><D><V><S><P><F><V><M><S><M><Q><K><N><K><W><D><A><T><R><S><L><R><F><N><Q><D><A><Q><R><E><D><D><Q><R><R><M><T><E><I><T><G><H><L><I><K><M><R><L><G><D><L><D><R><V><K><S><K><E><A><K><E><F><A><G><G><I><Y><S><R><L><E><A><Q><I><K><A><S><V><P><V><S><A><R><Q><S><S><S><E><K><N><T><R><S><K><S><R><F><G><Q><G><R><P><A>
Negatively regulates class switch recombination or isotype switching in splenic B-cells.<BOP>
Q6NSI8
Q8NCR3
MFI_HUMAN
Mitochondrial fission factor interactor
Homo
<M><P><W><K><E><E><S><E><F><T><K><Q><D><K><A><A><R><V><I><Q><Q><A><W><K><S><F><L><N><V><A><I><F><Q><H><F><K><S><L><I><D><L><R><R><Q><G><E><P><R><Q><I><V><K><Y><I><N><P><K><E><A><E><L><L><D><A><A><A><G><I><H><V><R><F><R><L><G><G><V><K><F><P><P><D><I><Y><Y><K><I><F><T><H><R><P><I><E><D><L><C><A><N><S><P><R><N><Y><A><K><L><P><A><K><H><T><S><H><N><K><N><D><H><L><Q><E><E><D><H><S><G><W><Y><H><R><I><E><N><N><G><W><R><P><V><S><D><T><F><W><L><S><T><D><G><M><V><V><E><D><K><K><E><S><E><F><H><F><S><K><L><K><R><R><Q><D><L><E><K><K><R><K><L><R><K><I><E><W><M><R><Q><M><Y><Y><S><G><S><L><E><A><K><S><T><H><H><E><T><L><G><L><I><H><T><A><T><K><G><L><I><R><A><F><E><D><G><G><I><D><S><V><M><E><W><E><V><D><E><V><L><N><W><T><N><T><L><N><F><D><E><Y><I><A><S><W><K><E><I><A><T><S><N><S><S><A><N><F><K><G><F><R><F><N><Q><A><Q><K><N><I><Y><N><Y><G><G><D><I><S><K><M><Q><M><G><I><P><D><D><T><Y><Y><E><N><V><Y><Q><E><P><N><V><T><R><L><T><P><D><S><T><Y><G><L>
Acts as an inhibitor of mitochondrial fission. Interacts with MFF and prevents DNM1L recruitment to mitochondria, promoting a more fused mitochondrial network.<BOP>
Q8NCR3
P22891
PROZ_HUMAN
Vitamin K-dependent protein Z
Homo
<M><A><G><C><V><P><L><L><Q><G><L><V><L><V><L><A><L><H><R><V><E><P><S><V><F><L><P><A><S><K><A><N><D><V><L><V><R><W><K><R><A><G><S><Y><L><L><E><E><L><F><E><G><N><L><E><K><E><C><Y><E><E><I><C><V><Y><E><E><A><R><E><V><F><E><N><E><V><V><T><D><E><F><W><R><R><Y><K><G><G><S><P><C><I><S><Q><P><C><L><H><N><G><S><C><Q><D><S><I><W><G><Y><T><C><T><C><S><P><G><Y><E><G><S><N><C><E><L><A><K><N><E><C><H><P><E><R><T><D><G><C><Q><H><F><C><L><P><G><Q><E><S><Y><T><C><S><C><A><Q><G><Y><R><L><G><E><D><H><K><Q><C><V><P><H><D><Q><C><A><C><G><V><L><T><S><E><K><R><A><P><D><L><Q><D><L><P><W><Q><V><K><L><T><N><S><E><G><K><D><F><C><G><G><V><I><I><R><E><N><F><V><L><T><T><A><K><C><S><L><L><H><R><N><I><T><V><K><T><Y><F><N><R><T><S><Q><D><P><L><M><I><K><I><T><H><V><H><V><H><M><R><Y><D><A><D><A><G><E><N><D><L><S><L><L><E><L><E><W><P><I><Q><C><P><G><A><G><L><P><V><C><T><P><E><K><D><F><A><E><H><L><L><I><P><R><T><R><G><L><L><S><G><W><A><R><N><G><T><D><L><G><N><S><L><T><T><R><P><V><T><L><V><E><G><E><E><C><G><Q><V><L><N><V><T><V><T><T><R><T><Y><C><E><R><S><S><V><A><A><M><H><W><M><D><G><S><V><V><T><R><E><H><R><G><S><W><F><L><T><G><V><L><G><S><Q><P><V><G><G><Q><A><H><M><V><L><V><T><K><V><S><R><Y><S><L><W><F><K><Q><I><M><N>
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.<BOP>
P22891
P30954
O10J1_HUMAN
Olfactory receptor-like protein HGMP07J
Homo
<M><L><L><C><F><R><F><G><N><Q><S><M><K><R><E><N><F><T><L><I><T><D><F><V><F><Q><G><F><S><S><F><H><E><Q><Q><I><T><L><F><G><V><F><L><A><L><Y><I><L><T><L><A><G><N><I><I><I><V><T><I><I><R><M><D><L><H><L><H><T><P><M><Y><F><F><L><S><M><L><S><T><S><E><T><V><Y><T><L><V><I><L><P><R><M><L><S><S><L><V><G><M><S><Q><P><I><S><L><A><G><C><A><T><Q><M><F><F><F><V><T><F><G><I><T><N><C><F><L><L><T><A><M><G><Y><D><R><Y><V><A><I><C><N><P><L><R><Y><M><V><I><M><N><K><R><L><R><I><Q><L><V><L><G><A><C><S><I><G><L><I><V><A><I><T><Q><V><T><S><V><F><R><L><P><F><C><A><R><K><V><P><H><F><F><C><D><I><R><P><V><M><K><L><S><C><I><D><T><T><V><N><E><I><L><T><L><I><I><S><V><L><V><L><V><V><P><M><G><L><V><F><I><S><Y><V><L><I><I><S><T><I><L><K><I><A><S><V><E><G><R><K><K><A><F><A><T><C><A><S><H><L><T><V><V><I><V><H><Y><S><C><A><S><I><A><Y><L><K><P><K><S><E><N><T><R><E><H><D><Q><L><I><S><V><T><Y><T><V><I><T><P><L><L><N><P><V><V><Y><T><L><R><N><K><E><V><K><D><A><L><C><R><A><V><G><G><K><F><S>
Odorant receptor.<BOP>
P30954
P08865
RSSA_HUMAN
Small ribosomal subunit protein uS2
Homo
<M><S><G><A><L><D><V><L><Q><M><K><E><E><D><V><L><K><F><L><A><A><G><T><H><L><G><G><T><N><L><D><F><Q><M><E><Q><Y><I><Y><K><R><K><S><D><G><I><Y><I><I><N><L><K><R><T><W><E><K><L><L><L><A><A><R><A><I><V><A><I><E><N><P><A><D><V><S><V><I><S><S><R><N><T><G><Q><R><A><V><L><K><F><A><A><A><T><G><A><T><P><I><A><G><R><F><T><P><G><T><F><T><N><Q><I><Q><A><A><F><R><E><P><R><L><L><V><V><T><D><P><R><A><D><H><Q><P><L><T><E><A><S><Y><V><N><L><P><T><I><A><L><C><N><T><D><S><P><L><R><Y><V><D><I><A><I><P><C><N><N><K><G><A><H><S><V><G><L><M><W><W><M><L><A><R><E><V><L><R><M><R><G><T><I><S><R><E><H><P><W><E><V><M><P><D><L><Y><F><Y><R><D><P><E><E><I><E><K><E><E><Q><A><A><A><E><K><A><V><T><K><E><E><F><Q><G><E><W><T><A><P><A><P><E><F><T><A><T><Q><P><E><V><A><D><W><S><E><G><V><Q><V><P><S><V><P><I><Q><Q><F><P><T><E><D><W><S><A><Q><P><A><T><E><D><W><S><A><A><P><T><A><Q><A><T><E><W><V><G><A><T><T><D><W><S>
(Microbial infection) Acts as a receptor for bacteria.<BOP>
P08865
Q9UMX3
BOK_HUMAN
Bcl-2-like protein 9
Homo
<M><E><V><L><R><R><S><S><V><F><A><A><E><I><M><D><A><F><D><R><S><P><T><D><K><E><L><V><A><Q><A><K><A><L><G><R><E><Y><V><H><A><R><L><L><R><A><G><L><S><W><S><A><P><E><R><A><A><P><V><P><G><R><L><A><E><V><C><A><V><L><L><R><L><G><D><E><L><E><M><I><R><P><S><V><Y><R><N><V><A><R><Q><L><H><I><S><L><Q><S><E><P><V><V><T><D><A><F><L><A><V><A><G><H><I><F><S><A><G><I><T><W><G><K><V><V><S><L><Y><A><V><A><A><G><L><A><V><D><C><V><R><Q><A><Q><P><A><M><V><H><A><L><V><D><C><L><G><E><F><V><R><K><T><L><A><T><W><L><R><R><R><G><G><W><T><D><V><L><K><C><V><V><S><T><D><P><G><L><R><S><H><W><L><V><A><A><L><C><S><F><G><R><F><L><K><A><A><F><F><V><L><L><P><E><R>
Pro-apoptotic molecule exerting its function through the mitochondrial pathway.<BOP>
Q9UMX3
Q8TDI8
TMC1_HUMAN
Transmembrane cochlear-expressed protein 1
Homo
<M><S><P><K><K><V><Q><I><K><V><E><E><K><E><D><E><T><E><E><S><S><S><E><E><E><E><E><V><E><D><K><L><P><R><R><E><S><L><R><P><K><R><K><R><T><R><D><V><I><N><E><D><D><P><E><P><E><P><E><D><E><E><T><R><K><A><R><E><K><E><R><R><R><R><L><K><R><G><A><E><E><E><E><I><D><E><E><E><L><E><R><L><K><A><E><L><D><E><K><R><Q><I><I><A><T><V><K><C><K><P><W><K><M><E><K><K><I><E><V><L><K><E><A><K><K><F><V><S><E><N><E><G><A><L><G><K><G><K><G><K><R><W><F><A><F><K><M><M><M><A><K><K><W><A><K><F><L><R><D><F><E><N><F><K><A><A><C><V><P><W><E><N><K><I><K><A><I><E><S><Q><F><G><S><S><V><A><S><Y><F><L><F><L><R><W><M><Y><G><V><N><M><V><L><F><I><L><T><F><S><L><I><M><L><P><E><Y><L><W><G><L><P><Y><G><S><L><P><R><K><T><V><P><R><A><E><E><A><S><A><A><N><F><G><V><L><Y><D><F><N><G><L><A><Q><Y><S><V><L><F><Y><G><Y><Y><D><N><K><R><T><I><G><W><M><N><F><R><L><P><L><S><Y><F><L><V><G><I><M><C><I><G><Y><S><F><L><V><V><L><K><A><M><T><K><N><I><G><D><D><G><G><G><D><D><N><T><F><N><F><S><W><K><V><F><T><S><W><D><Y><L><I><G><N><P><E><T><A><D><N><K><F><N><S><I><T><M><N><F><K><E><A><I><T><E><E><K><A><A><Q><V><E><E><N><V><H><L><I><R><F><L><R><F><L><A><N><F><F><V><F><L><T><L><G><G><S><G><Y><L><I><F><W><A><V><K><R><S><Q><E><F><A><Q><Q><D><P><D><T><L><G><W><W><E><K><N><E><M><N><M><V><M><S><L><L><G><M><F><C><P><T><L><F><D><L><F><A><E><L><E><D><Y><H><P><L><I><A><L><K><W><L><L><G><R><I><F><A><L><L><L><G><N><L><Y><V><F><I><L><A><L><M><D><E><I><N><N><K><I><E><E><E><K><L><V><K><A><N><I><T><L><W><E><A><N><M><I><K><A><Y><N><A><S><F><S><E><N><S><T><G><P><P><F><F><V><H><P><A><D><V><P><R><G><P><C><W><E><T><M><V><G><Q><E><F><V><R><L><T><V><S><D><V><L><T><T><Y><V><T><I><L><I><G><D><F><L><R><A><C><F><V><R><F><C><N><Y><C><W><C><W><D><L><E><Y><G><Y><P><S><Y><T><E><F><D><I><S><G><N><V><L><A><L><I><F><N><Q><G><M><I><W><M><G><S><F><F><A><P><S><L><P><G><I><N><I><L><R><L><H><T><S><M><Y><F><Q><C><W><A><V><M><C><C><N><V><P><E><A><R><V><F><K><A><S><R><S><N><N><F><Y><L><G><M><L><L><L><I><L><F><L><S><T><M><P><V><L><Y><M><I><V><S><L><P><P><S><F><D><C><G><P><F><S><G><K><N><R><M><F><E><V><I><G><E><T><L><E><H><D><F><P><S><W><M><A><K><I><L><R><Q><L><S><N><P><G><L><V><I><A><V><I><L><V><M><V><L><A><I><Y><Y><L><N><A><T><A><K><G><Q><K><A><A><N><L><D><L><K><K><K><M><K><M><Q><A><L><E><N><K><M><R><N><K><K><M><A><A><A><R><A><A><A><A><A><G><R><Q>
Probable ion channel required for the normal function of cochlear hair cells.<BOP>
Q8TDI8
Q9Y680
FKBP7_HUMAN
Rotamase
Homo
<M><P><K><T><M><H><F><L><F><R><F><I><V><F><F><Y><L><W><G><L><F><T><A><Q><R><Q><K><K><E><E><S><T><E><E><V><K><I><E><V><L><H><R><P><E><N><C><S><K><T><S><K><K><G><D><L><L><N><A><H><Y><D><G><Y><L><A><K><D><G><S><K><F><Y><C><S><R><T><Q><N><E><G><H><P><K><W><F><V><L><G><V><G><Q><V><I><K><G><L><D><I><A><M><T><D><M><C><P><G><E><K><R><K><V><V><I><P><P><S><F><A><Y><G><K><E><G><Y><A><E><G><K><I><P><P><D><A><T><L><I><F><E><I><E><L><Y><A><V><T><K><G><P><R><S><I><E><T><F><K><Q><I><D><M><D><N><D><R><Q><L><S><K><A><E><I><N><L><Y><L><Q><R><E><F><E><K><D><E><K><P><R><D><K><S><Y><Q><D><A><V><L><E><D><I><F><K><K><N><D><H><D><G><D><G><F><I><S><P><K><E><Y><N><V><Y><Q><H><D><E><L>
PPIases accelerate the folding of proteins during protein synthesis.<BOP>
Q9Y680
P02765
FETUA_HUMAN
Alpha-2-HS-glycoprotein chain B
Homo
<M><K><S><L><V><L><L><L><C><L><A><Q><L><W><G><C><H><S><A><P><H><G><P><G><L><I><Y><R><Q><P><N><C><D><D><P><E><T><E><E><A><A><L><V><A><I><D><Y><I><N><Q><N><L><P><W><G><Y><K><H><T><L><N><Q><I><D><E><V><K><V><W><P><Q><Q><P><S><G><E><L><F><E><I><E><I><D><T><L><E><T><T><C><H><V><L><D><P><T><P><V><A><R><C><S><V><R><Q><L><K><E><H><A><V><E><G><D><C><D><F><Q><L><L><K><L><D><G><K><F><S><V><V><Y><A><K><C><D><S><S><P><D><S><A><E><D><V><R><K><V><C><Q><D><C><P><L><L><A><P><L><N><D><T><R><V><V><H><A><A><K><A><A><L><A><A><F><N><A><Q><N><N><G><S><N><F><Q><L><E><E><I><S><R><A><Q><L><V><P><L><P><P><S><T><Y><V><E><F><T><V><S><G><T><D><C><V><A><K><E><A><T><E><A><A><K><C><N><L><L><A><E><K><Q><Y><G><F><C><K><A><T><L><S><E><K><L><G><G><A><E><V><A><V><T><C><M><V><F><Q><T><Q><P><V><S><S><Q><P><Q><P><E><G><A><N><E><A><V><P><T><P><V><V><D><P><D><A><P><P><S><P><P><L><G><A><P><G><L><P><P><A><G><S><P><P><D><S><H><V><L><L><A><A><P><P><G><H><Q><L><H><R><A><H><Y><D><L><R><H><T><F><M><G><V><V><S><L><G><S><P><S><G><E><V><S><H><P><R><K><T><R><T><V><V><Q><P><S><V><G><A><A><A><G><P><V><V><P><P><C><P><G><R><I><R><H><F><K><V>
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.<BOP>
P02765
P50443
S26A2_HUMAN
Solute carrier family 26 member 2
Homo
<M><S><S><E><S><K><E><Q><H><N><V><S><P><R><D><S><A><E><G><N><D><S><Y><P><S><G><I><H><L><E><L><Q><R><E><S><S><T><D><F><K><Q><F><E><T><N><D><Q><C><R><P><Y><H><R><I><L><I><E><R><Q><E><K><S><D><T><N><F><K><E><F><V><I><K><K><L><Q><K><N><C><Q><C><S><P><A><K><A><K><N><M><I><L><G><F><L><P><V><L><Q><W><L><P><K><Y><D><L><K><K><N><I><L><G><D><V><M><S><G><L><I><V><G><I><L><L><V><P><Q><S><I><A><Y><S><L><L><A><G><Q><E><P><V><Y><G><L><Y><T><S><F><F><A><S><I><I><Y><F><L><L><G><T><S><R><H><I><S><V><G><I><F><G><V><L><C><L><M><I><G><E><T><V><D><R><E><L><Q><K><A><G><Y><D><N><A><H><S><A><P><S><L><G><M><V><S><N><G><S><T><L><L><N><H><T><S><D><R><I><C><D><K><S><C><Y><A><I><M><V><G><S><T><V><T><F><I><A><G><V><Y><Q><V><A><M><G><F><F><Q><V><G><F><V><S><V><Y><L><S><D><A><L><L><S><G><F><V><T><G><A><S><F><T><I><L><T><S><Q><A><K><Y><L><L><G><L><N><L><P><R><T><N><G><V><G><S><L><I><T><T><W><I><H><V><F><R><N><I><H><K><T><N><L><C><D><L><I><T><S><L><L><C><L><L><V><L><L><P><T><K><E><L><N><E><H><F><K><S><K><L><K><A><P><I><P><I><E><L><V><V><V><V><A><A><T><L><A><S><H><F><G><K><L><H><E><N><Y><N><S><S><I><A><G><H><I><P><T><G><F><M><P><P><K><V><P><E><W><N><L><I><P><S><V><A><V><D><A><I><A><I><S><I><I><G><F><A><I><T><V><S><L><S><E><M><F><A><K><K><H><G><Y><T><V><K><A><N><Q><E><M><Y><A><I><G><F><C><N><I><I><P><S><F><F><H><C><F><T><T><S><A><A><L><A><K><T><L><V><K><E><S><T><G><C><H><T><Q><L><S><G><V><V><T><A><L><V><L><L><L><V><L><L><V><I><A><P><L><F><Y><S><L><Q><K><S><V><L><G><V><I><T><I><V><N><L><R><G><A><L><R><K><F><R><D><L><P><K><M><W><S><I><S><R><M><D><T><V><I><W><F><V><T><M><L><S><S><A><L><L><S><T><E><I><G><L><L><V><G><V><C><F><S><I><F><C><V><I><L><R><T><Q><K><P><K><S><S><L><L><G><L><V><E><E><S><E><V><F><E><S><V><S><A><Y><K><N><L><Q><I><K><P><G><I><K><I><F><R><F><V><A><P><L><Y><Y><I><N><K><E><C><F><K><S><A><L><Y><K><Q><T><V><N><P><I><L><I><K><V><A><W><K><K><A><A><K><R><K><I><K><E><K><V><V><T><L><G><G><I><Q><D><E><M><S><V><Q><L><S><H><D><P><L><E><L><H><T><I><V><I><D><C><S><A><I><Q><F><L><D><T><A><G><I><H><T><L><K><E><V><R><R><D><Y><E><A><I><G><I><Q><V><L><L><A><Q><C><N><P><T><V><R><D><S><L><T><N><G><E><Y><C><K><K><E><E><E><N><L><L><F><Y><S><V><Y><E><A><M><A><F><A><E><V><S><K><N><Q><K><G><V><C><V><P><N><G><L><S><L><S><S><D>
Sulfate transporter. May play a role in endochondral bone formation.<BOP>
P50443
P38159
RBMX_HUMAN
RNA-binding motif protein, X chromosome, N-terminally processed
Homo
<M><V><E><A><D><R><P><G><K><L><F><I><G><G><L><N><T><E><T><N><E><K><A><L><E><A><V><F><G><K><Y><G><R><I><V><E><V><L><L><M><K><D><R><E><T><N><K><S><R><G><F><A><F><V><T><F><E><S><P><A><D><A><K><D><A><A><R><D><M><N><G><K><S><L><D><G><K><A><I><K><V><E><Q><A><T><K><P><S><F><E><S><G><R><R><G><P><P><P><P><P><R><S><R><G><P><P><R><G><L><R><G><G><R><G><G><S><G><G><T><R><G><P><P><S><R><G><G><H><M><D><D><G><G><Y><S><M><N><F><N><M><S><S><S><R><G><P><L><P><V><K><R><G><P><P><P><R><S><G><G><P><P><P><K><R><S><A><P><S><G><P><V><R><S><S><S><G><M><G><G><R><A><P><V><S><R><G><R><D><S><Y><G><G><P><P><R><R><E><P><L><P><S><R><R><D><V><Y><L><S><P><R><D><D><G><Y><S><T><K><D><S><Y><S><S><R><D><Y><P><S><S><R><D><T><R><D><Y><A><P><P><P><R><D><Y><T><Y><R><D><Y><G><H><S><S><S><R><D><D><Y><P><S><R><G><Y><S><D><R><D><G><Y><G><R><D><R><D><Y><S><D><H><P><S><G><G><S><Y><R><D><S><Y><E><S><Y><G><N><S><R><S><A><P><P><T><R><G><P><P><P><S><Y><G><G><S><S><R><Y><D><D><Y><S><S><S><R><D><G><Y><G><G><S><R><D><S><Y><S><S><S><R><S><D><L><Y><S><S><G><R><D><R><V><G><R><Q><E><R><G><L><P><P><S><M><E><R><G><Y><P><P><P><R><D><S><Y><S><S><S><S><R><G><A><P><R><G><G><G><R><G><G><S><R><S><D><R><G><G><G><R><S><R><Y>
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of
P38159
A0A1W2PQL4
ZN722_HUMAN
Zinc finger protein 722
Homo
<M><A><E><R><P><G><S><P><G><S><R><E><M><R><L><L><T><F><R><D><I><A><I><E><F><S><L><E><E><W><Q><C><L><D><C><A><Q><Q><N><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><I><A><D><S><K><P><D><L><I><T><C><L><E><Q><N><K><E><A><W><N><I><K><R><N><E><M><V><A><K><H><P><V><T><C><S><H><F><T><Q><D><L><H><P><E><Q><G><I><K><H><S><L><Q><K><V><I><P><R><T><Y><G><K><C><G><H><E><N><L><Q><F><K><K><C><C><K><S><V><G><E><C><E><V><H><K><G><G><Y><N><E><V><K><Q><C><L><S><N><T><Q><N><K><I><F><Q><T><H><K><C><V><I><V><F><G><K><F><S><N><C><N><R><H><E><T><R><Y><T><G><K><K><H><F><K><C><K><K><Y><G><K><S><F><C><M><P><S><H><L><N><Q><H><Q><I><I><H><T><K><E><K><S><Y><K><C><E><E><C><G><K><S><F><K><R><S><S><N><C><T><T><H><K><R><I><H><T><G><E><K><P><Y><R><C><E><E><C><G><K><A><F><R><W><P><S><N><L><T><R><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><Q><A><F><R><R><S><S><T><L><T><N><H><K><R><I><H><T><G><E><R><P><Y><K><C><E><E><C><G><K><A><F><S><V><S><S><T><L><N><D><H><K><R><I><H><T><G><E><K><P><Y><T><C><E><E><C><G><R><A><F><N><C><S><S><T><L><K><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><D><K><A><F><K><R><H><S><S><L><A><K><H><K><I><I><H><T><G><E><K><P><Y><K><S><K>
May be involved in transcriptional regulation.<BOP>
A0A1W2PQL4
Q9BSF4
TIM29_HUMAN
Mitochondrial import inner membrane translocase subunit Tim29
Homo
<M><A><A><A><A><L><R><R><F><W><S><R><R><R><A><E><A><G><D><A><V><V><A><K><P><G><V><W><A><R><L><G><S><W><A><R><A><L><L><R><D><Y><A><E><A><C><R><D><A><S><A><E><A><R><A><R><P><G><R><A><A><V><Y><V><G><L><L><G><G><A><A><A><C><F><T><L><A><P><S><E><G><A><F><E><E><A><L><L><E><A><S><G><T><L><L><L><L><A><P><A><T><R><N><R><E><S><E><A><F><V><Q><R><L><L><W><L><R><G><R><G><R><L><R><Y><V><N><L><G><L><C><S><L><V><Y><E><A><P><F><D><A><Q><A><S><L><Y><Q><A><R><C><R><Y><L><Q><P><R><W><T><D><F><P><G><R><V><L><D><V><G><F><V><G><R><W><W><V><L><G><A><W><M><R><D><C><D><I><N><D><D><E><F><L><H><L><P><A><H><L><R><V><V><G><P><Q><Q><L><H><S><E><T><N><E><R><L><F><D><E><K><Y><K><P><V><V><L><T><D><D><Q><V><D><Q><A><L><W><E><E><Q><V><L><Q><K><E><K><K><D><R><L><A><L><S><Q><A><H><S><L><V><Q><A><E><A><P><R>
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.<BOP>
Q9BSF4
Q9P286
PAK5_HUMAN
p21-activated kinase 7
Homo
<M><F><G><K><K><K><K><K><I><E><I><S><G><P><S><N><F><E><H><R><V><H><T><G><F><D><P><Q><E><Q><K><F><T><G><L><P><Q><Q><W><H><S><L><L><A><D><T><A><N><R><P><K><P><M><V><D><P><S><C><I><T><P><I><Q><L><A><P><M><K><T><I><V><R><G><N><K><P><C><K><E><T><S><I><N><G><L><L><E><D><F><D><N><I><S><V><T><R><S><N><S><L><R><K><E><S><P><P><T><P><D><Q><G><A><S><S><H><G><P><G><H><A><E><E><N><G><F><I><T><F><S><Q><Y><S><S><E><S><D><T><T><A><D><Y><T><T><E><K><Y><R><E><K><S><L><Y><G><D><D><L><D><P><Y><Y><R><G><S><H><A><A><K><Q><N><G><H><V><M><K><M><K><H><G><E><A><Y><Y><S><E><V><K><P><L><K><S><D><F><A><R><F><S><A><D><Y><H><S><H><L><D><S><L><S><K><P><S><E><Y><S><D><L><K><W><E><Y><Q><R><A><S><S><S><S><P><L><D><Y><S><F><Q><F><T><P><S><R><T><A><G><T><S><G><C><S><K><E><S><L><A><Y><S><E><S><E><W><G><P><S><L><D><D><Y><D><R><R><P><K><S><S><Y><L><N><Q><T><S><P><Q><P><T><M><R><Q><R><S><R><S><G><S><G><L><Q><E><P><M><M><P><F><G><A><S><A><F><K><T><H><P><Q><G><H><S><Y><N><S><Y><T><Y><P><R><L><S><E><P><T><M><C><I><P><K><V><D><Y><D><R><A><Q><M><V><L><S><P><P><L><S><G><S><D><T><Y><P><R><G><P><A><K><L><P><Q><S><Q><S><K><S><G><Y><S><S><S><S><H><Q><Y><P><S><G><Y><H><K><A><T><L><Y><H><H><P><S><L><Q><S><S><S><Q><Y><I><S><T><A><S><Y><L><S><S><L><S><L><S><S><S><T><Y><P><P><P><S><W><G><S><S><S><D><Q><Q><P><S><R><V><S><H><E><Q><F><R><A><A><L><Q><L><V><V><S><P><G><D><P><R><E><Y><L><A><N><F><I><K><I><G><E><G><S><T><G><I><V><C><I><A><T><E><K><H><T><G><K><Q><V><A><V><K><K><M><D><L><R><K><Q><Q><R><R><E><L><L><F><N><E><V><V><I><M><R><D><Y><H><H><D><N><V><V><D><M><Y><S><S><Y><L><V><G><D><E><L><W><V><V><M><E><F><L><E><G><G><A><L><T><D><I><V><T><H><T><R><M><N><E><E><Q><I><A><T><V><C><L><S><V><L><R><A><L><S><Y><L><H><N><Q><G><V><I><H><R><D><I><K><S><D><S><I><L><L><T><S><D><G><R><I><K><L><S><D><F><G><F><C><A><Q><V><S><K><E><V><P><K><R><K><S><L><V><G><T><P><Y><W><M><A><P><E><V><I><S><R><L><P><Y><G><T><E><V><D><I><W><S><L><G><I><M><V><I><E><M><I><D><G><E><P><P><Y><F><N><E><P><P><L><Q><A><M><R><R><I><R><D><S><L><P><P><R><V><K><D><L><H><K><V><S><S><V><L><R><G><F><L><D><L><M><L><V><R><E><P><S><Q><R><A><T><A><Q><E><L><L><G><H><P><F><L><K><L><A><G><P><P><S><C><I><V><P><L><M><R><Q><Y><R><H><H>
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.<BOP>
Q9P286
O76071
CIAO1_HUMAN
WD repeat-containing protein 39
Homo
<M><K><D><S><L><V><L><L><G><R><V><P><A><H><P><D><S><R><C><W><F><L><A><W><N><P><A><G><T><L><L><A><S><C><G><G><D><R><R><I><R><I><W><G><T><E><G><D><S><W><I><C><K><S><V><L><S><E><G><H><Q><R><T><V><R><K><V><A><W><S><P><C><G><N><Y><L><A><S><A><S><F><D><A><T><T><C><I><W><K><K><N><Q><D><D><F><E><C><V><T><T><L><E><G><H><E><N><E><V><K><S><V><A><W><A><P><S><G><N><L><L><A><T><C><S><R><D><K><S><V><W><V><W><E><V><D><E><E><D><E><Y><E><C><V><S><V><L><N><S><H><T><Q><D><V><K><H><V><V><W><H><P><S><Q><E><L><L><A><S><A><S><Y><D><D><T><V><K><L><Y><R><E><E><E><D><D><W><V><C><C><A><T><L><E><G><H><E><S><T><V><W><S><L><A><F><D><P><S><G><Q><R><L><A><S><C><S><D><D><R><T><V><R><I><W><R><Q><Y><L><P><G><N><E><Q><G><V><A><C><S><G><S><D><P><S><W><K><C><I><C><T><L><S><G><F><H><S><R><T><I><Y><D><I><A><W><C><Q><L><T><G><A><L><A><T><A><C><G><D><D><A><I><R><V><F><Q><E><D><P><N><S><D><P><Q><Q><P><T><F><S><L><T><A><H><L><H><Q><A><H><S><Q><D><V><N><C><V><A><W><N><P><K><E><P><G><L><L><A><S><C><S><D><D><G><E><V><A><F><W><K><Y><Q><R><P><E><G><L>
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 . Seems to specifically modulate the transactivation activity of WT1 . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation .<BOP>
O76071
Q5UE93
PI3R6_HUMAN
p87 PI3K adapter protein
Homo
<M><E><S><S><D><V><E><L><D><L><Q><R><S><V><Q><A><V><L><R><E><L><S><T><Q><A><P><A><L><Q><S><N><Q><G><M><W><R><W><S><L><H><K><K><V><E><R><D><P><G><K><S><P><V><L><V><R><I><L><L><R><E><L><E><K><A><E><S><Q><D><L><R><H><V><I><I><P><L><L><H><T><V><M><Y><V><L><T><K><A><T><G><I><T><E><E><L><Y><Q><R><I><Y><A><F><C><T><R><L><L><T><L><P><T><P><Y><C><T><V><A><L><D><C><A><I><R><L><K><T><E><M><A><V><P><G><T><L><Y><Q><R><M><V><I><A><E><Q><N><L><T><N><E><L><Y><P><Y><Q><E><R><V><F><L><F><V><D><P><E><L><V><S><A><S><V><C><S><A><L><L><L><E><I><E><A><A><Q><A><Q><Q><T><P><E><T><C><M><R><H><V><V><S><H><A><L><Q><A><A><L><G><E><A><C><H><A><G><A><L><H><R><K><L><Q><A><S><P><R><R><T><L><E><H><Y><F><H><A><V><V><A><A><L><E><Q><M><A><S><E><A><S><P><S><R><E><G><H><V><E><R><L><E><E><I><Y><C><S><L><L><G><P><A><A><G><R><C><G><G><D><L><V><Q><E><R><P><P><S><I><P><L><P><S><P><Y><I><T><F><H><L><W><T><G><E><E><Q><L><W><K><E><L><V><L><F><L><R><P><R><S><Q><L><R><L><S><A><D><L><E><V><L><D><L><Q><G><L><R><P><D><R><E><L><A><R><V><S><V><L><S><T><D><S><G><I><E><R><D><L><P><T><G><A><D><E><L><P><A><P><G><S><P><E><M><E><R><A><G><L><Q><R><K><G><G><I><K><K><R><A><W><P><L><D><F><L><M><P><G><S><W><D><G><P><P><G><L><H><R><R><T><G><R><P><S><G><D><G><E><M><L><P><G><V><S><R><L><H><T><A><R><V><L><V><L><G><D><D><R><M><L><G><R><L><A><Q><A><Y><H><R><L><R><K><R><E><T><Q><K><F><C><L><T><P><R><L><S><L><Q><L><Y><Y><I><P><V><L><A><P><E><K><P><A><A><S><R><Q><P><E><L><G><E><L><A><T><F><L><G><R><V><D><P><W><Y><Q><S><N><V><N><T><L><C><P><A><I><H><K><L><A><E><M><P><P><S><L><D><T><S><R><T><V><D><P><F><I><L><D><V><I><T><Y><Y><I><R><M><G><T><Q><P><I><Y><F><Q><I><Y><T><V><K><I><F><F><S><D><L><S><Q><D><P><T><E><D><I><F><L><I><E><L><K><V><K><I><Q><D><S><K><F><P><K><D><G><F><S><P><R><R><R><G><V><A><E><G><P><G><A><E><L><S><L><C><Y><Q><K><A><L><L><S><H><R><P><R><E><V><T><V><S><L><R><A><T><G><L><I><L><K><A><I><P><A><S><D><T><E><V><S><G><S><S><H><C><P><L><P><A><A><P><V><T><D><H><T><C><L><N><V><N><V><T><E><V><V><K><S><S><N><L><A><G><K><S><F><S><T><V><T><N><T><F><R><T><N><N><I><Q><I><Q><S><R><D><Q><R><L><L><T><L><S><L><D><K><D><D><Q><R><T><F><R><D><V><V><R><F><E><V><A><P><C><P><E><P><C><S><G><A><Q><K><S><K><A><P><W><L><N><L><H><G><Q><Q><E><V><E><A><I><K><A><K><P><K><P><L><L><M><P><I><N><T><F><S><G><I><V><Q>
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.<BOP>
Q5UE93
O15554
KCNN4_HUMAN
Putative Gardos channel
Homo
<M><G><G><D><L><V><L><G><L><G><A><L><R><R><R><K><R><L><L><E><Q><E><K><S><L><A><G><W><A><L><V><L><A><G><T><G><I><G><L><M><V><L><H><A><E><M><L><W><F><G><G><C><S><W><A><L><Y><L><F><L><V><K><C><T><I><S><I><S><T><F><L><L><L><C><L><I><V><A><F><H><A><K><E><V><Q><L><F><M><T><D><N><G><L><R><D><W><R><V><A><L><T><G><R><Q><A><A><Q><I><V><L><E><L><V><V><C><G><L><H><P><A><P><V><R><G><P><P><C><V><Q><D><L><G><A><P><L><T><S><P><Q><P><W><P><G><F><L><G><Q><G><E><A><L><L><S><L><A><M><L><L><R><L><Y><L><V><P><R><A><V><L><L><R><S><G><V><L><L><N><A><S><Y><R><S><I><G><A><L><N><Q><V><R><F><R><H><W><F><V><A><K><L><Y><M><N><T><H><P><G><R><L><L><L><G><L><T><L><G><L><W><L><T><T><A><W><V><L><S><V><A><E><R><Q><A><V><N><A><T><G><H><L><S><D><T><L><W><L><I><P><I><T><F><L><T><I><G><Y><G><D><V><V><P><G><T><M><W><G><K><I><V><C><L><C><T><G><V><M><G><V><C><C><T><A><L><L><V><A><V><V><A><R><K><L><E><F><N><K><A><E><K><H><V><H><N><F><M><M><D><I><Q><Y><T><K><E><M><K><E><S><A><A><R><V><L><Q><E><A><W><M><F><Y><K><H><T><R><R><K><E><S><H><A><A><R><R><H><Q><R><K><L><L><A><A><I><N><A><F><R><Q><V><R><L><K><H><R><K><L><R><E><Q><V><N><S><M><V><D><I><S><K><M><H><M><I><L><Y><D><L><Q><Q><N><L><S><S><S><H><R><A><L><E><K><Q><I><D><T><L><A><G><K><L><D><A><L><T><E><L><L><S><T><A><L><G><P><R><Q><L><P><E><P><S><Q><Q><S><K>
Forms a voltage-independent potassium channel that is activated by intracellular calcium . Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells . Plays a role in the late stages of EGF-induced macropinocytosis .<BOP>
O15554
Q9P0M2
AKA7G_HUMAN
Protein kinase A-anchoring protein 7 isoform gamma
Homo
<M><E><R><P><E><A><G><G><I><N><S><N><E><C><E><N><V><S><R><K><K><K><M><S><E><E><F><E><A><N><T><M><D><S><L><V><D><M><P><F><A><T><V><D><I><Q><D><D><C><G><I><T><D><E><P><Q><I><N><L><K><R><S><Q><E><N><E><W><V><K><S><D><Q><V><K><K><R><K><K><K><R><K><D><Y><Q><P><N><Y><F><L><S><I><P><I><T><N><K><E><I><I><K><G><I><K><I><L><Q><N><A><I><I><Q><Q><D><E><R><L><A><K><A><M><V><S><D><G><S><F><H><I><T><L><L><V><M><Q><L><L><N><E><D><E><V><N><I><G><I><D><A><L><L><E><L><K><P><F><I><E><E><L><L><Q><G><K><H><L><T><L><P><F><Q><G><I><G><T><F><G><N><Q><V><G><F><V><K><L><A><E><G><D><H><V><N><S><L><L><E><I><A><E><T><A><N><R><T><F><Q><E><K><G><I><L><V><G><E><S><R><S><F><K><P><H><L><T><F><M><K><L><S><K><S><P><W><L><R><K><N><G><V><K><K><I><D><P><D><L><Y><E><K><F><I><S><H><R><F><G><E><E><I><L><Y><R><I><D><L><C><S><M><L><K><K><K><Q><S><N><G><Y><Y><H><C><E><S><S><I><V><I><G><E><K><N><G><G><E><P><D><D><A><E><L><V><R><L><S><K><R><L><V><E><N><A><V><L><K><A><V><Q><Q><Y><L><E><E><T><Q><N><K><N><K><P><G><E><G><S><S><V><K><T><E><A><A><D><Q><N><G><N><D><N><E><N><N><R><K>
Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<BOP>
Q9P0M2
O15120
PLCB_HUMAN
Lysophosphatidic acid acyltransferase beta
Homo
<M><E><L><W><P><C><L><A><A><A><L><L><L><L><L><L><L><V><Q><L><S><R><A><A><E><F><Y><A><K><V><A><L><Y><C><A><L><C><F><T><V><S><A><V><A><S><L><V><C><L><L><R><H><G><G><R><T><V><E><N><M><S><I><I><G><W><F><V><R><S><F><K><Y><F><Y><G><L><R><F><E><V><R><D><P><R><R><L><Q><E><A><R><P><C><V><I><V><S><N><H><Q><S><I><L><D><M><M><G><L><M><E><V><L><P><E><R><C><V><Q><I><A><K><R><E><L><L><F><L><G><P><V><G><L><I><M><Y><L><G><G><V><F><F><I><N><R><Q><R><S><S><T><A><M><T><V><M><A><D><L><G><E><R><M><V><R><E><N><L><K><V><W><I><Y><P><E><G><T><R><N><D><N><G><D><L><L><P><F><K><K><G><A><F><Y><L><A><V><Q><A><Q><V><P><I><V><P><V><V><Y><S><S><F><S><S><F><Y><N><T><K><K><K><F><F><T><S><G><T><V><T><V><Q><V><L><E><A><I><P><T><S><G><L><T><A><A><D><V><P><A><L><V><D><T><C><H><R><A><M><R><T><T><F><L><H><I><S><K><T><P><Q><E><N><G><A><T><A><G><S><G><V><Q><P><A><Q>
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.<BOP>
O15120
Q02928
CP4AB_HUMAN
Long-chain fatty acid omega-monooxygenase
Homo
<M><S><V><S><V><L><S><P><S><R><L><L><G><D><V><S><G><I><L><Q><A><A><S><L><L><I><L><L><L><L><L><I><K><A><V><Q><L><Y><L><H><R><Q><W><L><L><K><A><L><Q><Q><F><P><C><P><P><S><H><W><L><F><G><H><I><Q><E><L><Q><Q><D><Q><E><L><Q><R><I><Q><K><W><V><E><T><F><P><S><A><C><P><H><W><L><W><G><G><K><V><R><V><Q><L><Y><D><P><D><Y><M><K><V><I><L><G><R><S><D><P><K><S><H><G><S><Y><R><F><L><A><P><W><I><G><Y><G><L><L><L><L><N><G><Q><T><W><F><Q><H><R><R><M><L><T><P><A><F><H><Y><D><I><L><K><P><Y><V><G><L><M><A><D><S><V><R><V><M><L><D><K><W><E><E><L><L><G><Q><D><S><P><L><E><V><F><Q><H><V><S><L><M><T><L><D><T><I><M><K><C><A><F><S><H><Q><G><S><I><Q><V><D><R><N><S><Q><S><Y><I><Q><A><I><S><D><L><N><N><L><V><F><S><R><V><R><N><A><F><H><Q><N><D><T><I><Y><S><L><T><S><A><G><R><W><T><H><R><A><C><Q><L><A><H><Q><H><T><D><Q><V><I><Q><L><R><K><A><Q><L><Q><K><E><G><E><L><E><K><I><K><R><K><R><H><L><D><F><L><D><I><L><L><L><A><K><M><E><N><G><S><I><L><S><D><K><D><L><R><A><E><V><D><T><F><M><F><E><G><H><D><T><T><A><S><G><I><S><W><I><L><Y><A><L><A><T><H><P><K><H><Q><E><R><C><R><E><E><I><H><S><L><L><G><D><G><A><S><I><T><W><N><H><L><D><Q><M><P><Y><T><T><M><C><I><K><E><A><L><R><L><Y><P><P><V><P><G><I><G><R><E><L><S><T><P><V><T><F><P><D><G><R><S><L><P><K><G><I><M><V><L><L><S><I><Y><G><L><H><H><N><P><K><V><W><P><N><P><E><V><F><D><P><F><R><F><A><P><G><S><A><Q><H><S><H><A><F><L><P><F><S><G><G><S><R><N><C><I><G><K><Q><F><A><M><N><E><L><K><V><A><T><A><L><T><L><L><R><F><E><L><L><P><D><P><T><R><I><P><I><P><I><A><R><L><V><L><K><S><K><N><G><I><H><L><R><L><R><R><L><P><N><P><C><E><D><K><D><Q><L>
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid . Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver . Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting
Q02928
P11802
CDK4_HUMAN
PSK-J3
Homo
<M><A><T><S><R><Y><E><P><V><A><E><I><G><V><G><A><Y><G><T><V><Y><K><A><R><D><P><H><S><G><H><F><V><A><L><K><S><V><R><V><P><N><G><G><G><G><G><G><G><L><P><I><S><T><V><R><E><V><A><L><L><R><R><L><E><A><F><E><H><P><N><V><V><R><L><M><D><V><C><A><T><S><R><T><D><R><E><I><K><V><T><L><V><F><E><H><V><D><Q><D><L><R><T><Y><L><D><K><A><P><P><P><G><L><P><A><E><T><I><K><D><L><M><R><Q><F><L><R><G><L><D><F><L><H><A><N><C><I><V><H><R><D><L><K><P><E><N><I><L><V><T><S><G><G><T><V><K><L><A><D><F><G><L><A><R><I><Y><S><Y><Q><M><A><L><T><P><V><V><V><T><L><W><Y><R><A><P><E><V><L><L><Q><S><T><Y><A><T><P><V><D><M><W><S><V><G><C><I><F><A><E><M><F><R><R><K><P><L><F><C><G><N><S><E><A><D><Q><L><G><K><I><F><D><L><I><G><L><P><P><E><D><D><W><P><R><D><V><S><L><P><R><G><A><F><P><P><R><G><P><R><P><V><Q><S><V><V><P><E><M><E><E><S><G><A><Q><L><L><L><E><M><L><T><F><N><P><H><K><R><I><S><A><F><R><A><L><Q><H><S><Y><L><H><K><D><E><G><N><P><E>
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.<BOP>
P11802
Q59EK9
RUN3A_HUMAN
Rap2-interacting protein 8
Homo
<M><E><A><S><F><V><Q><T><T><M><A><L><G><L><S><S><K><K><A><S><S><R><N><V><A><V><E><R><K><N><L><I><T><V><C><R><F><S><V><K><T><L><L><E><K><Y><T><A><E><P><I><D><D><S><S><E><E><F><V><N><F><A><A><I><L><E><Q><I><L><S><H><R><F><K><A><C><A><P><A><G><P><V><S><W><F><S><S><D><G><Q><R><G><F><W><D><Y><I><R><L><A><C><S><K><V><P><N><N><C><V><S><S><I><E><N><M><E><N><I><S><T><A><R><A><K><G><R><A><W><I><R><V><A><L><M><E><K><R><M><S><E><Y><I><T><T><A><L><R><D><T><R><T><T><R><R><F><Y><D><S><G><A><I><M><L><R><D><E><A><T><I><L><T><G><M><L><I><G><L><S><A><I><D><F><S><F><C><L><K><G><E><V><L><D><G><K><T><P><V><V><I><D><Y><T><P><Y><L><K><F><T><Q><S><Y><D><Y><L><T><D><E><E><E><R><H><S><A><E><S><S><T><S><E><D><N><S><P><E><H><P><Y><L><P><L><V><T><D><E><D><S><W><Y><S><K><W><H><K><M><E><Q><K><F><R><I><V><Y><A><Q><K><G><Y><L><E><E><L><V><R><L><R><E><S><Q><L><K><D><L><E><A><E><N><R><R><L><Q><L><Q><L><E><E><A><A><A><Q><N><Q><R><E><K><R><E><L><E><G><V><I><L><E><L><Q><E><Q><L><T><G><L><I><P><S><D><H><A><P><L><A><Q><G><S><K><E><L><T><T><P><L><V><N><Q><W><P><S><L><G><T><L><N><G><A><E><G><A><S><N><S><K><L><Y><R><R><H><S><F><M><S><T><E><P><L><S><A><E><A><S><L><S><S><D><S><Q><R><L><G><E><G><T><R><D><E><E><P><W><G><P><I><G><K><D><P><T><P><S><M><L><G><L><C><G><S><L><A><S><I><P><S><C><K><S><L><A><S><F><K><S><N><E><C><L><V><S><D><S><P><E><G><S><P><A><L><S><P><S>
May act as an effector of RAP2A in neuronal cells.<BOP>
Q59EK9
Q9BQA1
MEP50_HUMAN
p44/Mep50
Homo
<M><R><K><E><T><P><P><P><L><V><P><P><A><A><R><E><W><N><L><P><P><N><A><P><A><C><M><E><R><Q><L><E><A><A><R><Y><R><S><D><G><A><L><L><L><G><A><S><S><L><S><G><R><C><W><A><G><S><L><W><L><F><K><D><P><C><A><A><P><N><E><G><F><C><S><A><G><V><Q><T><E><A><G><V><A><D><L><T><W><V><G><E><R><G><I><L><V><A><S><D><S><G><A><V><E><L><W><E><L><D><E><N><E><T><L><I><V><S><K><F><C><K><Y><E><H><D><D><I><V><S><T><V><S><V><L><S><S><G><T><Q><A><V><S><G><S><K><D><I><C><I><K><V><W><D><L><A><Q><Q><V><V><L><S><S><Y><R><A><H><A><A><Q><V><T><C><V><A><A><S><P><H><K><D><S><V><F><L><S><C><S><E><D><N><R><I><L><L><W><D><T><R><C><P><K><P><A><S><Q><I><G><C><S><A><P><G><Y><L><P><T><S><L><A><W><H><P><Q><Q><S><E><V><F><V><F><G><D><E><N><G><T><V><S><L><V><D><T><K><S><T><S><C><V><L><S><S><A><V><H><S><Q><C><V><T><G><L><V><F><S><P><H><S><V><P><F><L><A><S><L><S><E><D><C><S><L><A><V><L><D><S><S><L><S><E><L><F><R><S><Q><A><H><R><D><F><V><R><D><A><T><W><S><P><L><N><H><S><L><L><T><T><V><G><W><D><H><Q><V><V><H><H><V><V><P><T><E><P><L><P><A><P><G><P><A><S><V><T><E>
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones . This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage .<BOP>
Q9BQA1
Q6UW88
EPGN_HUMAN
Epithelial mitogen
Homo
<M><A><L><G><V><P><I><S><V><Y><L><L><F><N><A><M><T><A><L><T><E><E><A><A><V><T><V><T><P><P><I><T><A><Q><Q><G><N><W><T><V><N><K><T><E><A><D><N><I><E><G><P><I><A><L><K><F><S><H><L><C><L><E><D><H><N><S><Y><C><I><N><G><A><C><A><F><H><H><E><L><E><K><A><I><C><R><C><F><T><G><Y><T><G><E><R><C><E><H><L><T><L><T><S><Y><A><V><D><S><Y><E><K><Y><I><A><I><G><I><G><V><G><L><L><L><S><G><F><L><V><I><F><Y><C><Y><I><R><K><R><C><L><K><L><K><S><P><Y><N><V><C><S><G><E><R><R><P><L>
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.<BOP>
Q6UW88
P17482
HXB9_HUMAN
Homeobox protein Hox-2E
Homo
<M><S><I><S><G><T><L><S><S><Y><Y><V><D><S><I><I><S><H><E><S><E><D><A><P><P><A><K><F><P><S><G><Q><Y><A><S><S><R><Q><P><G><H><A><E><H><L><E><F><P><S><C><S><F><Q><P><K><A><P><V><F><G><A><S><W><A><P><L><S><P><H><A><S><G><S><L><P><S><V><Y><H><P><Y><I><Q><P><Q><G><V><P><P><A><E><S><R><Y><L><R><T><W><L><E><P><A><P><R><G><E><A><A><P><G><Q><G><Q><A><A><V><K><A><E><P><L><L><G><A><P><G><E><L><L><K><Q><G><T><P><E><Y><S><L><E><T><S><A><G><R><E><A><V><L><S><N><Q><R><P><G><Y><G><D><N><K><I><C><E><G><S><E><D><K><E><R><P><D><Q><T><N><P><S><A><N><W><L><H><A><R><S><S><R><K><K><R><C><P><Y><T><K><Y><Q><T><L><E><L><E><K><E><F><L><F><N><M><Y><L><T><R><D><R><R><H><E><V><A><R><L><L><N><L><S><E><R><Q><V><K><I><W><F><Q><N><R><R><M><K><M><K><K><M><N><K><E><Q><G><K><E>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P17482
Q7RTS6
OTOP2_HUMAN
Otopetrin-2
Homo
<M><S><E><E><L><A><Q><G><P><K><E><S><P><P><A><P><R><A><G><P><R><E><V><W><K><K><G><G><R><L><L><S><V><L><L><A><V><N><V><L><L><L><A><C><T><L><I><S><G><G><A><F><N><K><V><A><V><Y><D><T><D><V><F><A><L><L><T><A><M><M><L><L><A><T><L><W><I><L><F><Y><L><L><R><T><V><R><C><P><C><A><V><P><Y><R><D><A><H><A><G><P><I><W><L><R><G><G><L><V><L><F><G><I><C><T><L><I><M><D><V><F><K><T><G><Y><Y><S><S><F><F><E><C><Q><S><A><I><K><I><L><H><P><L><I><Q><A><V><F><V><I><I><Q><T><Y><F><L><W><V><S><A><K><D><C><V><H><V><H><L><D><L><T><W><C><G><L><M><F><T><L><T><T><N><L><A><I><W><M><A><A><V><V><D><E><S><V><H><Q><S><H><S><Y><S><S><S><H><S><N><A><S><H><A><R><L><I><S><D><Q><H><A><D><N><P><V><G><G><D><S><C><L><C><S><T><A><V><C><Q><I><F><Q><Q><G><Y><F><Y><L><Y><P><F><N><I><E><Y><S><L><F><A><S><T><M><L><Y><V><M><W><K><N><V><G><R><F><L><A><S><T><P><G><H><S><H><T><P><T><P><V><S><L><F><R><E><T><F><F><A><G><P><V><L><G><L><L><L><F><V><V><G><L><A><V><F><I><I><Y><E><V><Q><V><S><G><D><G><S><R><T><R><Q><A><L><V><I><Y><Y><S><F><N><I><V><C><L><G><L><T><T><L><V><S><L><S><G><S><I><I><Y><R><F><D><R><R><A><M><D><H><H><K><N><P><T><R><T><L><D><V><A><L><L><M><G><A><A><L><G><Q><Y><A><I><S><Y><Y><S><I><V><A><V><V><A><G><T><P><Q><D><L><L><A><G><L><N><L><T><H><A><L><L><M><I><A><Q><H><T><F><Q><N><M><F><I><I><E><S><L><H><R><G><P><P><G><A><E><P><H><S><T><H><P><K><E><P><C><Q><D><L><T><F><T><N><L><D><A><L><H><T><L><S><A><C><P><P><N><P><G><L><V><S><P><S><P><S><D><Q><R><E><A><V><A><I><V><S><T><P><R><S><Q><W><R><R><Q><C><L><K><D><I><S><L><F><L><L><L><C><N><V><I><L><W><I><M><P><A><F><G><A><R><P><H><F><S><N><T><V><E><V><D><F><Y><G><Y><S><L><W><A><V><I><V><N><I><C><L><P><F><G><I><F><Y><R><M><H><A><V><S><S><L><L><E><V><Y><V><L><S>
Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.<BOP>
Q7RTS6
Q8NBI3
DRAXI_HUMAN
Neucrin
Homo
<M><A><G><P><A><I><H><T><A><P><M><L><F><L><V><L><L><L><P><L><E><L><S><L><A><G><A><L><A><P><G><T><P><A><R><N><L><P><E><N><H><I><D><L><P><G><P><A><L><W><T><P><Q><A><S><H><H><R><R><R><G><P><G><K><K><E><W><G><P><G><L><P><S><Q><A><Q><D><G><A><V><V><T><A><T><R><Q><A><S><R><L><P><E><A><E><G><L><L><P><E><Q><S><P><A><G><L><L><Q><D><K><D><L><L><L><G><L><A><L><P><Y><P><E><K><E><N><R><P><P><G><W><E><R><T><R><K><R><S><R><E><H><K><R><R><R><D><R><L><R><L><H><Q><G><R><A><L><V><R><G><P><S><S><L><M><K><K><A><E><L><S><E><A><Q><V><L><D><A><A><M><E><E><S><S><T><S><L><A><P><T><M><F><F><L><T><T><F><E><A><A><P><A><T><E><E><S><L><I><L><P><V><T><S><L><R><P><Q><Q><A><Q><P><R><S><D><G><E><V><M><P><T><L><D><M><A><L><F><D><W><T><D><Y><E><D><L><K><P><D><G><W><P><S><A><K><K><K><E><K><H><R><G><K><L><S><S><D><G><N><E><T><S><P><A><E><G><E><P><C><D><H><H><Q><D><C><L><P><G><T><C><C><D><L><R><E><H><L><C><T><P><H><N><R><G><L><N><N><K><C><F><D><D><C><M><C><V><E><G><L><R><C><Y><A><K><F><H><R><N><R><R><V><T><R><R><K><G><R><C><V><E><P><E><T><A><N><G><D><Q><G><S><F><I><N><V>
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.<BOP>
Q8NBI3
Q86SG5
S1A7A_HUMAN
S100 calcium-binding protein A7A
Homo
<M><S><N><T><Q><A><E><R><S><I><I><G><M><I><D><M><F><H><K><Y><T><G><R><D><G><K><I><E><K><P><S><L><L><T><M><M><K><E><N><F><P><N><F><L><S><A><C><D><K><K><G><I><H><Y><L><A><T><V><F><E><K><K><D><K><N><E><D><K><K><I><D><F><S><E><F><L><S><L><L><G><D><I><A><A><D><Y><H><K><Q><S><H><G><A><A><P><C><S><G><G><S><Q>
May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.<BOP>
Q86SG5
P58335
ANTR2_HUMAN
Capillary morphogenesis gene 2 protein
Homo
<M><V><A><E><R><S><P><A><R><S><P><G><S><W><L><F><P><G><L><W><L><L><V><L><S><G><P><G><G><L><L><R><A><Q><E><Q><P><S><C><R><R><A><F><D><L><Y><F><V><L><D><K><S><G><S><V><A><N><N><W><I><E><I><Y><N><F><V><Q><Q><L><A><E><R><F><V><S><P><E><M><R><L><S><F><I><V><F><S><S><Q><A><T><I><I><L><P><L><T><G><D><R><G><K><I><S><K><G><L><E><D><L><K><R><V><S><P><V><G><E><T><Y><I><H><E><G><L><K><L><A><N><E><Q><I><Q><K><A><G><G><L><K><T><S><S><I><I><I><A><L><T><D><G><K><L><D><G><L><V><P><S><Y><A><E><K><E><A><K><I><S><R><S><L><G><A><S><V><Y><C><V><G><V><L><D><F><E><Q><A><Q><L><E><R><I><A><D><S><K><E><Q><V><F><P><V><K><G><G><F><Q><A><L><K><G><I><I><N><S><I><L><A><Q><S><C><T><E><I><L><E><L><Q><P><S><S><V><C><V><G><E><E><F><Q><I><V><L><S><G><R><G><F><M><L><G><S><R><N><G><S><V><L><C><T><Y><T><V><N><E><T><Y><T><T><S><V><K><P><V><S><V><Q><L><N><S><M><L><C><P><A><P><I><L><N><K><A><G><E><T><L><D><V><S><V><S><F><N><G><G><K><S><V><I><S><G><S><L><I><V><T><A><T><E><C><S><N><G><I><A><A><I><I><V><I><L><V><L><L><L><L><L><G><I><G><L><M><W><W><F><W><P><L><C><C><K><V><V><I><K><D><P><P><P><P><P><A><P><A><P><K><E><E><E><E><E><P><L><P><T><K><K><W><P><T><V><D><A><S><Y><Y><G><G><R><G><V><G><G><I><K><R><M><E><V><R><W><G><D><K><G><S><T><E><E><G><A><R><L><E><K><A><K><N><A><V><V><K><I><P><E><E><T><E><E><P><I><R><P><R><P><P><R><P><K><P><T><H><Q><P><P><Q><T><K><W><Y><T><P><I><K><G><R><L><D><A><L><W><A><L><L><R><R><Q><Y><D><R><V><S><L><M><R><P><Q><E><G><D><E><V><C><I><W><E><C><I><E><K><E><L><T><A>
(Microbial infection) Receptor for the protective antigen (PA) of B.anthracis . Binding of PA leads to heptamerization of the receptor-PA complex . Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway . In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm .<BOP>
P58335
Q9Y337
KLK5_HUMAN
Stratum corneum tryptic enzyme
Homo
<M><A><T><A><R><P><P><W><M><W><V><L><C><A><L><I><T><A><L><L><L><G><V><T><E><H><V><L><A><N><N><D><V><S><C><D><H><P><S><N><T><V><P><S><G><S><N><Q><D><L><G><A><G><A><G><E><D><A><R><S><D><D><S><S><S><R><I><I><N><G><S><D><C><D><M><H><T><Q><P><W><Q><A><A><L><L><L><R><P><N><Q><L><Y><C><G><A><V><L><V><H><P><Q><W><L><L><T><A><A><H><C><R><K><K><V><F><R><V><R><L><G><H><Y><S><L><S><P><V><Y><E><S><G><Q><Q><M><F><Q><G><V><K><S><I><P><H><P><G><Y><S><H><P><G><H><S><N><D><L><M><L><I><K><L><N><R><R><I><R><P><T><K><D><V><R><P><I><N><V><S><S><H><C><P><S><A><G><T><K><C><L><V><S><G><W><G><T><T><K><S><P><Q><V><H><F><P><K><V><L><Q><C><L><N><I><S><V><L><S><Q><K><R><C><E><D><A><Y><P><R><Q><I><D><D><T><M><F><C><A><G><D><K><A><G><R><D><S><C><Q><G><D><S><G><G><P><V><V><C><N><G><S><L><Q><G><L><V><S><W><G><D><Y><P><C><A><R><P><N><R><P><G><V><Y><T><N><L><C><K><F><T><K><W><I><Q><E><T><I><Q><A><N><S>
May be involved in desquamation.<BOP>
Q9Y337
Q8WU66
TSEAR_HUMAN
Thrombospondin-type laminin G domain and EAR repeat-containing protein
Homo
<M><S><A><L><L><S><L><C><F><V><L><P><L><A><A><P><G><H><G><T><Q><G><W><E><P><C><T><D><L><R><P><L><D><I><L><A><E><V><V><P><S><D><G><A><T><S><G><I><R><I><V><Q><V><H><G><A><R><G><L><Q><L><S><V><A><A><P><R><T><M><S><F><P><A><S><R><I><F><S><Q><C><D><L><F><P><E><E><F><S><I><V><V><T><L><R><V><P><N><L><P><P><K><R><N><E><Y><L><L><T><V><V><A><E><E><S><D><L><L><L><L><G><L><R><L><S><P><A><Q><L><H><F><L><F><L><R><E><D><T><A><G><A><W><Q><T><R><V><S><F><R><S><P><A><L><V><D><G><R><W><H><T><L><V><L><A><V><S><A><G><V><F><S><L><T><T><D><C><G><L><P><V><D><I><M><A><D><V><P><F><P><A><T><L><S><V><K><G><A><R><F><F><V><G><S><R><R><R><A><K><G><L><F><M><G><L><V><R><Q><L><V><L><L><P><G><S><D><A><T><P><R><L><C><P><S><R><N><A><P><L><A><V><L><S><I><P><R><V><L><Q><A><L><T><G><K><P><E><D><N><E><V><L><K><Y><P><Y><E><T><N><I><R><V><T><L><G><P><Q><P><P><C><T><E><V><E><D><A><Q><F><W><F><D><A><S><R><K><G><L><Y><L><C><V><G><N><E><W><V><S><V><L><A><A><K><E><R><L><D><Y><V><E><E><H><Q><N><L><S><T><N><S><E><T><L><G><I><E><V><F><R><I><P><Q><V><G><L><F><V><A><T><A><N><R><K><A><T><S><A><V><Y><K><W><T><E><E><K><F><V><S><Y><Q><N><I><P><T><H><Q><A><Q><A><W><R><H><F><T><I><G><K><K><I><F><L><A><V><A><N><F><E><P><D><E><K><G><Q><E><F><S><V><I><Y><K><W><S><H><R><K><L><K><F><T><P><Y><Q><S><I><A><T><H><S><A><R><D><W><E><A><F><E><V><D><G><E><H><F><L><A><V><A><N><H><R><E><G><D><N><H><N><I><D><S><V><I><Y><K><W><N><P><A><T><R><L><F><E><A><N><Q><T><I><A><T><S><G><A><Y><D><W><E><F><F><S><V><G><P><Y><S><F><L><V><V><A><N><T><F><N><G><T><S><T><K><V><H><S><H><L><Y><I><R><L><L><G><S><F><Q><L><F><Q><S><F><P><T><F><G><A><A><D><W><E><V><F><Q><I><G><E><R><I><F><L><A><V><A><N><S><H><S><Y><D><V><E><M><Q><V><Q><N><D><S><Y><V><I><N><S><V><I><Y><E><L><N><V><T><A><Q><A><F><V><K><F><Q><D><I><L><T><C><S><A><L><D><W><E><F><F><S><V><G><E><D><Y><F><L><V><V><A><N><S><F><D><G><R><T><F><S><V><N><S><I><I><Y><R><W><Q><G><Y><E><G><F><V><A><V><H><S><L><P><T><V><G><C><R><D><W><E><A><F><S><T><T><A><G><A><Y><L><I><Y><S><S><A><K><E><P><L><S><R><V><L><R><L><R><T><R>
Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway . May play a role in development or function of the auditory system .<BOP>
Q8WU66
Q9NQ89
CL004_HUMAN
Protein C12orf4
Homo
<M><K><K><N><R><E><R><F><C><N><R><E><R><E><F><V><Y><K><F><K><V><G><S><Q><C><L><E><L><R><V><P><L><K><F><P><V><Q><E><N><A><S><H><L><H><G><R><L><M><L><L><H><S><L><P><C><F><I><E><K><D><L><K><E><A><L><T><Q><F><I><E><E><E><S><L><S><D><Y><D><R><D><A><E><A><S><L><A><A><V><K><S><G><E><V><D><L><H><Q><L><A><S><T><W><A><K><A><Y><A><E><T><T><L><E><H><A><R><P><E><E><P><S><W><D><E><D><F><A><D><V><Y><H><D><L><I><H><S><P><A><S><E><T><L><L><N><L><E><H><N><Y><F><V><S><I><S><E><L><I><G><E><R><D><V><E><L><K><K><L><R><E><R><Q><G><I><E><M><E><K><V><M><Q><E><L><G><K><S><L><T><D><Q><D><V><N><S><L><A><A><Q><H><F><E><S><Q><Q><D><L><E><N><K><W><S><N><E><L><K><Q><S><T><A><I><Q><K><Q><E><Y><Q><E><W><V><I><K><L><H><Q><D><L><K><N><P><N><N><S><S><L><S><E><E><I><K><V><Q><P><S><Q><F><R><E><S><V><E><A><I><G><R><I><Y><E><E><Q><R><K><L><E><E><S><F><T><I><H><L><G><A><Q><L><K><T><M><H><N><L><R><L><L><R><A><D><M><L><D><F><C><K><H><K><R><N><H><R><S><G><V><K><L><H><R><L><Q><T><A><L><S><L><Y><S><T><S><L><C><G><L><V><L><L><V><D><N><R><I><N><S><Y><S><G><I><K><R><D><F><A><T><V><C><Q><E><C><T><D><F><H><F><P><R><I><E><E><Q><L><E><V><V><Q><Q><V><V><L><Y><A><R><T><Q><R><R><S><K><L><K><E><S><L><D><S><G><N><Q><N><G><G><N><D><D><K><T><K><N><A><E><R><N><Y><L><N><V><L><P><G><E><F><Y><I><T><R><H><S><N><L><S><E><I><H><V><A><F><H><L><C><V><D><D><H><V><K><S><G><N><I><T><A><R><D><P><A><I><M><G><L><R><N><I><L><K><V><C><C><T><H><D><I><T><T><I><S><I><P><L><L><L><V><H><D><M><S><E><E><M><T><I><P><W><C><L><R><R><A><E><L><V><F><K><C><V><K><G><F><M><M><E><M><A><S><W><D><G><G><I><S><R><T><V><Q><F><L><V><P><Q><S><I><S><E><E><M><F><Y><Q><L><S><N><M><L><P><Q><I><F><R><V><S><S><T><L><T><L><T><S><K><H>
Plays a role in mast cell degranulation.<BOP>
Q9NQ89
Q6UWK7
GP15L_HUMAN
Secreted protein C10orf99
Homo
<M><R><L><L><V><L><S><S><L><L><C><I><L><L><L><C><F><S><I><F><S><T><E><G><K><R><R><P><A><K><A><W><S><G><R><R><T><R><L><C><C><H><R><V><P><S><P><N><S><T><N><L><K><G><H><H><V><R><L><C><K><P><C><K><L><E><P><E><P><R><L><W><V><V><P><G><A><L><P><Q><V>
Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus .<BOP>
Q6UWK7
P07988
PSPB_HUMAN
Pulmonary surfactant-associated proteolipid SPL(Phe)
Homo
<M><A><E><S><H><L><L><Q><W><L><L><L><L><L><P><T><L><C><G><P><G><T><A><A><W><T><T><S><S><L><A><C><A><Q><G><P><E><F><W><C><Q><S><L><E><Q><A><L><Q><C><R><A><L><G><H><C><L><Q><E><V><W><G><H><V><G><A><D><D><L><C><Q><E><C><E><D><I><V><H><I><L><N><K><M><A><K><E><A><I><F><Q><D><T><M><R><K><F><L><E><Q><E><C><N><V><L><P><L><K><L><L><M><P><Q><C><N><Q><V><L><D><D><Y><F><P><L><V><I><D><Y><F><Q><N><Q><T><D><S><N><G><I><C><M><H><L><G><L><C><K><S><R><Q><P><E><P><E><Q><E><P><G><M><S><D><P><L><P><K><P><L><R><D><P><L><P><D><P><L><L><D><K><L><V><L><P><V><L><P><G><A><L><Q><A><R><P><G><P><H><T><Q><D><L><S><E><Q><Q><F><P><I><P><L><P><Y><C><W><L><C><R><A><L><I><K><R><I><Q><A><M><I><P><K><G><A><L><A><V><A><V><A><Q><V><C><R><V><V><P><L><V><A><G><G><I><C><Q><C><L><A><E><R><Y><S><V><I><L><L><D><T><L><L><G><R><M><L><P><Q><L><V><C><R><L><V><L><R><C><S><M><D><D><S><A><G><P><R><S><P><T><G><E><W><L><P><R><D><S><E><C><H><L><C><M><S><V><T><T><Q><A><G><N><S><S><E><Q><A><I><P><Q><A><M><L><Q><A><C><V><G><S><W><L><D><R><E><K><C><K><Q><F><V><E><Q><H><T><P><Q><L><L><T><L><V><P><R><G><W><D><A><H><T><T><C><Q><A><L><G><V><C><G><T><M><S><S><P><L><Q><C><I><H><S><P><D><L>
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.<BOP>
P07988
Q6P2I7
EBLN2_HUMAN
Endogenous Borna-like N element-2
Homo
<M><G><Y><F><L><K><L><Y><A><Y><V><N><S><H><S><L><F><V><W><V><C><D><R><S><Y><K><R><S><F><R><P><M><I><L><N><K><I><K><E><L><S><R><N><Q><F><S><T><M><S><H><L><R><K><D><S><Q><P><S><S><P><G><D><D><A><M><D><R><S><G><L><P><D><L><Q><G><R><F><E><L><S><G><K><N><R><Q><Y><P><L><D><A><L><E><P><Q><P><S><I><G><D><I><K><D><I><K><K><A><A><K><S><M><L><D><P><A><H><K><S><H><F><H><P><V><T><P><S><L><V><F><L><C><F><I><F><D><G><L><H><Q><A><L><L><S><V><G><V><S><K><R><S><N><T><V><V><G><N><E><N><E><E><R><G><T><P><Y><A><S><R><F><K><D><M><P><N><F><I><A><L><E><K><S><S><V><L><R><H><C><C><D><L><L><I><G><I><A><A><G><S><S><D><K><I><C><T><S><S><L><Q><V><Q><R><R><F><K><A><M><M><A><S><I><G><R><L><S><H><G><E><S><A><D><L><L><I><S><C><N><A><E><S><A><I><G><W><I><S><S><R><P><W><V><G><E><L><M><F><T><L><L><F><G><D><F><E><S><P><L><H><K><L><R><K><S><S>
May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.<BOP>
Q6P2I7
Q96T52
IMP2L_HUMAN
IMP2-like protein
Homo
<M><A><Q><S><Q><G><W><V><K><R><Y><I><K><A><F><C><K><G><F><F><V><A><V><P><V><A><V><T><F><L><D><R><V><A><C><V><A><R><V><E><G><A><S><M><Q><P><S><L><N><P><G><G><S><Q><S><S><D><V><V><L><L><N><H><W><K><V><R><N><F><E><V><H><R><G><D><I><V><S><L><V><S><P><K><N><P><E><Q><K><I><I><K><R><V><I><A><L><E><G><D><I><V><R><T><I><G><H><K><N><R><Y><V><K><V><P><R><G><H><I><W><V><E><G><D><H><H><G><H><S><F><D><S><N><S><F><G><P><V><S><L><G><L><L><H><A><H><A><T><H><I><L><W><P><P><E><R><W><Q><K><L><E><S><V><L><P><P><E><R><L><P><V><Q><R><E><E><E>
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.<BOP>
Q96T52
Q9H7X0
NAA60_HUMAN
N-alpha-acetyltransferase F
Homo
<M><T><E><V><V><P><S><S><A><L><S><E><V><S><L><R><L><L><C><H><D><D><I><D><T><V><K><H><L><C><G><D><W><F><P><I><E><Y><P><D><S><W><Y><R><D><I><T><S><N><K><K><F><F><S><L><A><A><T><Y><R><G><A><I><V><G><M><I><V><A><E><I><K><N><R><T><K><I><H><K><E><D><G><D><I><L><A><S><N><F><S><V><D><T><Q><V><A><Y><I><L><S><L><G><V><V><K><E><F><R><K><H><G><I><G><S><L><L><L><E><S><L><K><D><H><I><S><T><T><A><Q><D><H><C><K><A><I><Y><L><H><V><L><T><T><N><N><T><A><I><N><F><Y><E><N><R><D><F><K><Q><H><H><Y><L><P><Y><Y><Y><S><I><R><G><V><L><K><D><G><F><T><Y><V><L><Y><I><N><G><G><H><P><P><W><T><I><L><D><Y><I><Q><H><L><G><S><A><L><A><S><L><S><P><C><S><I><P><H><R><V><Y><R><Q><A><H><S><L><L><C><S><F><L><P><W><S><G><I><S><S><K><S><G><I><E><Y><S><R><T><M>
N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol . Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met . Required for normal chromosomal segregation during anaphase . May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences .<BOP>
Q9H7X0
Q9HCL3
ZFP14_HUMAN
Zinc finger protein 531
Homo
<M><A><H><G><S><V><T><F><R><D><V><A><I><D><F><S><Q><E><E><W><E><F><L><D><P><A><Q><R><D><L><Y><R><D><V><M><W><E><N><Y><S><N><F><I><S><L><G><P><S><I><S><K><P><D><V><I><T><L><L><D><E><E><R><K><E><P><G><M><V><V><R><E><G><T><R><R><Y><C><P><D><L><E><S><R><Y><R><T><N><T><L><S><P><E><K><D><I><Y><E><I><Y><S><F><Q><W><D><I><M><E><R><I><K><S><Y><S><L><Q><G><S><I><F><R><N><D><W><E><C><K><S><K><I><E><G><E><K><E><Q><Q><E><G><Y><F><G><Q><V><K><I><T><S><E><K><M><T><T><Y><K><R><H><N><F><L><T><E><Y><Q><I><V><H><N><G><E><K><V><Y><E><C><K><E><C><R><K><T><F><I><R><R><S><T><L><S><Q><H><L><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><Q><A><F><R><Q><R><A><H><L><I><R><H><H><K><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><T><V><L><Q><E><L><T><Q><H><Q><R><L><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><V><H><Q><Q><L><A><R><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><D><C><G><K><T><F><R><Q><C><T><H><L><T><R><H><Q><R><L><H><T><A><E><K><L><Y><E><C><K><E><C><G><K><A><F><V><C><G><P><D><L><R><V><H><Q><K><I><H><F><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><I><C><Q><Q><L><T><V><H><Q><S><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><R><L><R><Q><Q><L><V><R><H><Q><R><I><H><T><R><E><K><P><Y><E><C><M><E><C><W><K><T><F><S><S><Y><S><Q><L><I><S><H><Q><S><I><H><I><G><E><R><P><Y><E><C><E><E><C><G><K><A><F><R><L><L><S><Q><L><T><Q><H><Q><S><I><H><T><G><E><K><P><Y><E><C><K><E><C><R><K><P><F><R><L><L><S><Q><L><T><Q><H><Q><S><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><L><Y><S><F><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><K><K><A><F><R><Q><H><S><H><L><T><Q><H><Q><K><I><H><N><G><I>
May be involved in transcriptional regulation.<BOP>
Q9HCL3
O94941
RNF37_HUMAN
Ubiquitin-conjugating enzyme 7-interacting protein 5
Homo
<M><V><I><N><L><C><L><P><Q><F><R><P><R><I><H><C><N><K><I><S><A><D><G><Y><E><V><E><N><L><I><S><E><D><L><T><K><R><S><H><G><F><R><T><E><Y><F><I><K><P><P><V><Y><V><T><V><S><F><P><F><N><V><E><I><C><R><I><N><I><D><L><T><A><G><G><G><Q><N><V><T><G><L><E><M><Y><T><S><A><S><S><S><R><V><S><W><N><T><P><Q><C><R><T><L><G><P><A><E><P><S><V><P><D><K><E><A><F><T><L><V><G><K><V><L><L><K><N><Q><S><Q><V><V><F><S><H><R><G><F><K><A><R><P><P><F><G><A><M><E><A><T><L><P><S><P><A><V><V><A><Q><E><L><W><N><K><G><A><L><S><L><S><H><V><A><H><L><R><I><C><I><T><H><V><T><G><G><G><I><P><C><I><K><R><L><E><V><W><G><Q><P><A><K><T><C><S><Q><E><V><I><D><S><I><L><L><V><T><S><E><N><L><P><Q><D><V><A><L><Q><A><P><A><L><P><M><E><S><D><C><D><P><G><D><Q><P><E><S><Q><Q><A><P><S><S><L><Q><K><L><A><E><I><I><Q><D><V><P><E><E><F><L><D><P><I><T><L><E><I><M><P><C><P><M><L><L><P><S><G><K><V><I><D><Q><S><T><L><E><K><C><N><R><S><E><A><T><W><G><R><V><P><S><D><P><F><T><G><V><A><F><T><P><H><S><Q><P><L><P><H><P><S><L><K><A><R><I><D><H><F><L><L><Q><H><S><I><P><G><C><H><L><L><G><R><A><Q><T><A><L><A><V><I><P><S><S><I><V><L><P><S><Q><K><R><K><I><E><Q><A><E><H><V><P><D><S><N><F><G><V><N><A><S><C><F><S><A><T><S><P><L><V><L><P><T><T><S><E><H><T><A><K><K><M><K><A><T><N><E><P><S><L><T><H><M><D><C><S><T><G><P><L><S><H><E><Q><K><L><S><Q><S><L><E><I><A><L><A><S><T><L><G><S><M><P><S><F><T><A><R><L><T><R><G><Q><L><Q><H><L><G><T><R><G><S><N><T><S><W><R><P><G><T><G><S><E><Q><P><G><S><I><L><G><P><E><C><A><S><C><K><R><V><F><S><P><Y><F><K><K><E><P><V><Y><Q><L><P><C><G><H><L><L><C><R><P><C><L><G><E><K><Q><R><S><L><P><M><T><C><T><A><C><Q><R><P><V><A><S><Q><D><V><L><R><V><H><F>
May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.<BOP>
O94941
Q5SZQ8
CELF3_HUMAN
Trinucleotide repeat-containing gene 4 protein
Homo
<M><K><E><P><D><A><I><K><L><F><V><G><Q><I><P><R><H><L><E><E><K><D><L><K><P><I><F><E><Q><F><G><R><I><F><E><L><T><V><I><K><D><K><Y><T><G><L><H><K><G><C><A><F><L><T><Y><C><A><R><D><S><A><L><K><A><Q><S><A><L><H><E><Q><K><T><L><P><G><M><N><R><P><I><Q><V><K><P><A><D><S><E><S><R><G><E><D><R><K><L><F><V><G><M><L><G><K><Q><Q><T><D><E><D><V><R><K><M><F><E><P><F><G><T><I><D><E><C><T><V><L><R><G><P><D><G><T><S><K><G><C><A><F><V><K><F><Q><T><H><A><E><A><Q><A><A><I><N><T><L><H><S><S><R><T><L><P><G><A><S><S><S><L><V><V><K><F><A><D><T><E><K><E><R><G><L><R><R><M><Q><Q><V><A><T><Q><L><G><M><F><S><P><I><A><L><Q><F><G><A><Y><S><A><Y><T><Q><A><L><M><Q><Q><Q><A><A><L><V><A><A><H><S><A><Y><L><S><P><M><A><T><M><A><A><V><Q><M><Q><H><M><A><A><I><N><A><N><G><L><I><A><T><P><I><T><P><S><S><G><T><S><T><P><P><A><I><A><A><T><P><V><S><A><I><P><A><A><L><G><V><N><G><Y><S><P><V><P><T><Q><P><T><G><Q><P><A><P><D><A><L><Y><P><N><G><V><H><P><Y><P><A><Q><S><P><A><A><P><V><D><P><L><Q><Q><A><Y><A><G><M><Q><H><Y><T><A><A><Y><P><A><A><Y><S><L><V><A><P><A><F><P><Q><P><P><A><L><V><A><Q><Q><P><P><P><P><P><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><R><E><G><P><D><G><C><N><I><F><I><Y><H><L><P><Q><E><F><T><D><S><E><I><L><Q><M><F><V><P><F><G><H><V><I><S><A><K><V><F><V><D><R><A><T><N><Q><S><K><C><F><G><F><V><S><F><D><N><P><A><S><A><Q><A><A><I><Q><A><M><N><G><F><Q><I><G><M><K><R><L><K><V><Q><L><K><R><P><K><D><A><N><R><P><Y>
RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.<BOP>
Q5SZQ8
Q8TDP1
RNH2C_HUMAN
Ribonuclease HI subunit C
Homo
<M><E><S><G><D><E><A><A><I><E><R><H><R><V><H><L><R><S><A><T><L><R><D><A><V><P><A><T><L><H><L><L><P><C><E><V><A><V><D><G><P><A><P><V><G><R><F><F><T><P><A><I><R><Q><G><P><E><G><L><E><V><S><F><R><G><R><C><L><R><G><E><E><V><A><V><P><P><G><L><V><G><Y><V><M><V><T><E><E><K><K><V><S><M><G><K><P><D><P><L><R><D><S><G><T><D><D><Q><E><E><E><P><L><E><R><D><F><D><R><F><I><G><A><T><A><N><F><S><R><F><T><L><W><G><L><E><T><I><P><G><P><D><A><K><V><R><G><A><L><T><W><P><S><L><A><A><A><I><H><A><Q><V><P><E><D>
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.<BOP>
Q8TDP1
Q3SXY8
AR13B_HUMAN
ADP-ribosylation factor-like protein 2-like 1
Homo
<M><F><S><L><M><A><S><C><C><G><W><F><K><R><W><R><E><P><V><R><K><V><T><L><L><M><V><G><L><D><N><A><G><K><T><A><T><A><K><G><I><Q><G><E><Y><P><E><D><V><A><P><T><V><G><F><S><K><I><N><L><R><Q><G><K><F><E><V><T><I><F><D><L><G><G><G><I><R><I><R><G><I><W><K><N><Y><Y><A><E><S><Y><G><V><I><F><V><V><D><S><S><D><E><E><R><M><E><E><T><K><E><A><M><S><E><M><L><R><H><P><R><I><S><G><K><P><I><L><V><L><A><N><K><Q><D><K><E><G><A><L><G><E><A><D><V><I><E><C><L><S><L><E><K><L><V><N><E><H><K><C><L><C><Q><I><E><P><C><S><A><I><S><G><Y><G><K><K><I><D><K><S><I><K><K><G><L><Y><W><L><L><H><V><I><A><R><D><F><D><A><L><N><E><R><I><Q><K><E><T><T><E><Q><R><A><L><E><E><Q><E><K><Q><E><R><A><E><R><V><R><K><L><R><E><E><R><K><Q><N><E><Q><E><Q><A><E><L><D><G><T><S><G><L><A><E><L><D><P><E><P><T><N><P><F><Q><P><I><A><S><V><I><I><E><N><E><G><K><L><E><R><E><K><K><N><Q><K><M><E><K><D><S><D><G><C><H><L><K><H><K><M><E><H><E><Q><I><E><T><Q><G><Q><V><N><H><N><G><Q><K><N><N><E><F><G><L><V><E><N><Y><K><E><A><L><T><Q><Q><L><K><N><E><D><E><T><D><R><P><S><L><E><S><A><N><G><K><K><K><T><K><K><L><R><M><K><R><N><H><R><V><E><P><L><N><I><D><D><C><A><P><E><S><P><T><P><P><P><P><P><P><P><V><G><W><G><T><P><K><V><T><R><L><P><K><L><E><P><L><G><E><T><H><H><N><D><F><Y><R><K><P><L><P><P><L><A><V><P><Q><R><P><N><S><D><A><H><D><V><I><S>
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidence is required to confirm these data.<BOP>
Q3SXY8
Q9Y316
MEMO1_HUMAN
Mediator of ErbB2-driven cell motility 1
Homo
<M><S><N><R><V><V><C><R><E><A><S><H><A><G><S><W><Y><T><A><S><G><P><Q><L><N><A><Q><L><E><G><W><L><S><Q><V><Q><S><T><K><R><P><A><R><A><I><I><A><P><H><A><G><Y><T><Y><C><G><S><C><A><A><H><A><Y><K><Q><V><D><P><S><I><T><R><R><I><F><I><L><G><P><S><H><H><V><P><L><S><R><C><A><L><S><S><V><D><I><Y><R><T><P><L><Y><D><L><R><I><D><Q><K><I><Y><G><E><L><W><K><T><G><M><F><E><R><M><S><L><Q><T><D><E><D><E><H><S><I><E><M><H><L><P><Y><T><A><K><A><M><E><S><H><K><D><E><F><T><I><I><P><V><L><V><G><A><L><S><E><S><K><E><Q><E><F><G><K><L><F><S><K><Y><L><A><D><P><S><N><L><F><V><V><S><S><D><F><C><H><W><G><Q><R><F><R><Y><S><Y><Y><D><E><S><Q><G><E><I><Y><R><S><I><E><H><L><D><K><M><G><M><S><I><I><E><Q><L><D><P><V><S><F><S><N><Y><L><K><K><Y><H><N><T><I><C><G><R><H><P><I><G><V><L><L><N><A><I><T><E><L><Q><K><N><G><M><N><M><S><F><S><F><L><N><Y><A><Q><S><S><Q><C><R><N><W><Q><D><S><S><V><S><Y><A><A><G><A><L><T><V><H>
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.<BOP>
Q9Y316
P30988
CALCR_HUMAN
Calcitonin receptor
Homo
<M><R><F><T><F><T><S><R><C><L><A><L><F><L><L><L><N><H><P><T><P><I><L><P><A><F><S><N><Q><T><Y><P><T><I><E><P><K><P><F><L><Y><V><V><G><R><K><K><M><M><D><A><Q><Y><K><C><Y><D><R><M><Q><Q><L><P><A><Y><Q><G><E><G><P><Y><C><N><R><T><W><D><G><W><L><C><W><D><D><T><P><A><G><V><L><S><Y><Q><F><C><P><D><Y><F><P><D><F><D><P><S><E><K><V><T><K><Y><C><D><E><K><G><V><W><F><K><H><P><E><N><N><R><T><W><S><N><Y><T><M><C><N><A><F><T><P><E><K><L><K><N><A><Y><V><L><Y><Y><L><A><I><V><G><H><S><L><S><I><F><T><L><V><I><S><L><G><I><F><V><F><F><R><S><L><G><C><Q><R><V><T><L><H><K><N><M><F><L><T><Y><I><L><N><S><M><I><I><I><I><H><L><V><E><V><V><P><N><G><E><L><V><R><R><D><P><V><S><C><K><I><L><H><F><F><H><Q><Y><M><M><A><C><N><Y><F><W><M><L><C><E><G><I><Y><L><H><T><L><I><V><V><A><V><F><T><E><K><Q><R><L><R><W><Y><Y><L><L><G><W><G><F><P><L><V><P><T><T><I><H><A><I><T><R><A><V><Y><F><N><D><N><C><W><L><S><V><E><T><H><L><L><Y><I><I><H><G><P><V><M><A><A><L><V><V><N><F><F><F><L><L><N><I><V><R><V><L><V><T><K><M><R><E><T><H><E><A><E><S><H><M><Y><L><K><A><V><K><A><T><M><I><L><V><P><L><L><G><I><Q><F><V><V><F><P><W><R><P><S><N><K><M><L><G><K><I><Y><D><Y><V><M><H><S><L><I><H><F><Q><G><F><F><V><A><T><I><Y><C><F><C><N><N><E><V><Q><T><T><V><K><R><Q><W><A><Q><F><K><I><Q><W><N><Q><R><W><G><R><R><P><S><N><R><S><A><R><A><A><A><A><A><A><E><A><G><D><I><P><I><Y><I><C><H><Q><E><L><R><N><E><P><A><N><N><Q><G><E><E><S><A><E><I><I><P><L><N><I><I><E><Q><E><S><S><A>
Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase . Does not undergo receptor internalization following ligand binding .<BOP>
P30988
P12074
CX6A1_HUMAN
Cytochrome c oxidase subunit VIA-liver
Homo
<M><A><V><V><G><V><S><S><V><S><R><L><L><G><R><S><R><P><Q><L><G><R><P><M><S><S><G><A><H><G><E><E><G><S><A><R><M><W><K><T><L><T><F><F><V><A><L><P><G><V><A><V><S><M><L><N><V><Y><L><K><S><H><H><G><E><H><E><R><P><E><F><I><A><Y><P><H><L><R><I><R><T><K><P><F><P><W><G><D><G><N><H><T><L><F><H><N><P><H><V><N><P><L><P><T><G><Y><E><D><E>
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons
P12074
Q8IWA4
MFN1_HUMAN
Transmembrane GTPase MFN1
Homo
<M><A><E><P><V><S><P><L><K><H><F><V><L><A><K><K><A><I><T><A><I><F><D><Q><L><L><E><F><V><T><E><G><S><H><F><V><E><A><T><Y><K><N><P><E><L><D><R><I><A><T><E><D><D><L><V><E><M><Q><G><Y><K><D><K><L><S><I><I><G><E><V><L><S><R><R><H><M><K><V><A><F><F><G><R><T><S><S><G><K><S><S><V><I><N><A><M><L><W><D><K><V><L><P><S><G><I><G><H><I><T><N><C><F><L><S><V><E><G><T><D><G><D><K><A><Y><L><M><T><E><G><S><D><E><K><K><S><V><K><T><V><N><Q><L><A><H><A><L><H><M><D><K><D><L><K><A><G><C><L><V><R><V><F><W><P><K><A><K><C><A><L><L><R><D><D><L><V><L><V><D><S><P><G><T><D><V><T><T><E><L><D><S><W><I><D><K><F><C><L><D><A><D><V><F><V><L><V><A><N><S><E><S><T><L><M><N><T><E><K><H><F><F><H><K><V><N><E><R><L><S><K><P><N><I><F><I><L><N><N><R><W><D><A><S><A><S><E><P><E><Y><M><E><D><V><R><R><Q><H><M><E><R><C><L><H><F><L><V><E><E><L><K><V><V><N><A><L><E><A><Q><N><R><I><F><F><V><S><A><K><E><V><L><S><A><R><K><Q><K><A><Q><G><M><P><E><S><G><V><A><L><A><E><G><F><H><A><R><L><Q><E><F><Q><N><F><E><Q><I><F><E><E><C><I><S><Q><S><A><V><K><T><K><F><E><Q><H><T><I><R><A><K><Q><I><L><A><T><V><K><N><I><M><D><S><V><N><L><A><A><E><D><K><R><H><Y><S><V><E><E><R><E><D><Q><I><D><R><L><D><F><I><R><N><Q><M><N><L><L><T><L><D><V><K><K><K><I><K><E><V><T><E><E><V><A><N><K><V><S><C><A><M><T><D><E><I><C><R><L><S><V><L><V><D><E><F><C><S><E><F><H><P><N><P><D><V><L><K><I><Y><K><S><E><L><N><K><H><I><E><D><G><M><G><R><N><L><A><D><R><C><T><D><E><V><N><A><L><V><L><Q><T><Q><Q><E><I><I><E><N><L><K><P><L><L><P><A><G><I><Q><D><K><L><H><T><L><I><P><C><K><K><F><D><L><S><Y><N><L><N><Y><H><K><L><C><S><D><F><Q><E><D><I><V><F><R><F><S><L><G><W><S><S><L><V><H><R><F><L><G><P><R><N><A><Q><R><V><L><L><G><L><S><E><P><I><F><Q><L><P><R><S><L><A><S><T><P><T><A><P><T><T><P><A><T><P><D><N><A><S><Q><E><E><L><M><I><T><L><V><T><G><L><A><S><V><T><S><R><T><S><M><G><I><I><I><V><G><G><V><I><W><K><T><I><G><W><K><L><L><S><V><S><L><T><M><Y><G><A><L><Y><L><Y><E><R><L><S><W><T><T><H><A><K><E><R><A><F><K><Q><Q><F><V><N><Y><A><T><E><K><L><R><M><I><V><S><S><T><S><A><N><C><S><H><Q><V><K><Q><Q><I><A><T><T><F><A><R><L><C><Q><Q><V><D><I><T><Q><K><Q><L><E><E><E><I><A><R><L><P><K><E><I><D><Q><L><E><K><I><Q><N><N><S><K><L><L><R><N><K><A><V><Q><L><E><N><E><L><E><N><F><T><K><Q><F><L><P><S><S><N><E><E><S>
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion . Membrane clustering requires GTPase activity . It may involve a major rearrangement of the coiled coil domains . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events . Overexpression induces the formation of mitochondrial networks (in vitro) . Has low GTPase activity .<BOP>
Q8IWA4
Q9BZM1
PG12A_HUMAN
Phosphatidylcholine 2-acylhydrolase 12A
Homo
<M><A><L><L><S><R><P><A><L><T><L><L><L><L><L><M><A><A><V><V><R><C><Q><E><Q><A><Q><T><T><D><W><R><A><T><L><K><T><I><R><N><G><V><H><K><I><D><T><Y><L><N><A><A><L><D><L><L><G><G><E><D><G><L><C><Q><Y><K><C><S><D><G><S><K><P><F><P><R><Y><G><Y><K><P><S><P><P><N><G><C><G><S><P><L><F><G><V><H><L><N><I><G><I><P><S><L><T><K><C><C><N><Q><H><D><R><C><Y><E><T><C><G><K><S><K><N><D><C><D><E><E><F><Q><Y><C><L><S><K><I><C><R><D><V><Q><K><T><L><G><L><T><Q><H><V><Q><A><C><E><T><T><V><E><L><L><F><D><S><V><I><H><L><G><C><K><P><Y><L><D><S><Q><R><A><A><C><R><C><H><Y><E><E><K><T><D><L>
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.<BOP>
Q9BZM1
Q9BZJ7
GPR62_HUMAN
G-protein coupled receptor KPG_005
Homo
<M><A><N><S><T><G><L><N><A><S><E><V><A><G><S><L><G><L><I><L><A><A><V><V><E><V><G><A><L><L><G><N><G><A><L><L><V><V><V><L><R><T><P><G><L><R><D><A><L><Y><L><A><H><L><C><V><V><D><L><L><A><A><A><S><I><M><P><L><G><L><L><A><A><P><P><P><G><L><G><R><V><R><L><G><P><A><P><C><R><A><A><R><F><L><S><A><A><L><L><P><A><C><T><L><G><V><A><A><L><G><L><A><R><Y><R><L><I><V><H><P><L><R><P><G><S><R><P><P><P><V><L><V><L><T><A><V><W><A><A><A><G><L><L><G><A><L><S><L><L><G><T><P><P><A><P><P><P><A><P><A><R><C><S><V><L><A><G><G><L><G><P><F><R><P><L><W><A><L><L><A><F><A><L><P><A><L><L><L><L><G><A><Y><G><G><I><F><V><V><A><R><R><A><A><L><R><P><P><R><P><A><R><G><S><R><L><H><S><D><S><L><D><S><R><L><S><I><L><P><P><L><R><P><R><L><P><G><G><K><A><A><L><A><P><A><L><A><V><G><Q><F><A><A><C><W><L><P><Y><G><C><A><C><L><A><P><A><A><R><A><A><E><A><E><A><A><V><T><W><V><A><Y><S><A><F><A><A><H><P><F><L><Y><G><L><L><Q><R><P><V><R><L><A><L><G><R><L><S><R><R><A><L><P><G><P><V><R><A><C><T><P><Q><A><W><H><P><R><A><L><L><Q><C><L><Q><R><P><P><E><G><P><A><V><G><P><S><E><A><P><E><Q><T><P><E><L><A><G><G><R><S><P><A><Y><Q><G><P><P><E><S><S><L><S>
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways . Has spontaneous activity for beta-arrestin recruitment . Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization .<BOP>
Q9BZJ7
Q06643
TNFC_HUMAN
Tumor necrosis factor ligand superfamily member 3
Homo
<M><G><A><L><G><L><E><G><R><G><G><R><L><Q><G><R><G><S><L><L><L><A><V><A><G><A><T><S><L><V><T><L><L><L><A><V><P><I><T><V><L><A><V><L><A><L><V><P><Q><D><Q><G><G><L><V><T><E><T><A><D><P><G><A><Q><A><Q><Q><G><L><G><F><Q><K><L><P><E><E><E><P><E><T><D><L><S><P><G><L><P><A><A><H><L><I><G><A><P><L><K><G><Q><G><L><G><W><E><T><T><K><E><Q><A><F><L><T><S><G><T><Q><F><S><D><A><E><G><L><A><L><P><Q><D><G><L><Y><Y><L><Y><C><L><V><G><Y><R><G><R><A><P><P><G><G><G><D><P><Q><G><R><S><V><T><L><R><S><S><L><Y><R><A><G><G><A><Y><G><P><G><T><P><E><L><L><L><E><G><A><E><T><V><T><P><V><L><D><P><A><R><R><Q><G><Y><G><P><L><W><Y><T><S><V><G><F><G><G><L><V><Q><L><R><R><G><E><R><V><Y><V><N><I><S><H><P><D><M><V><D><F><A><R><G><K><T><F><F><G><A><V><M><V><G>
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.<BOP>
Q06643
O14771
ZN213_HUMAN
Zinc finger protein with KRAB and SCAN domains 21
Homo
<M><A><A><P><L><E><A><Q><D><Q><A><P><G><E><G><E><G><L><L><I><V><K><V><E><D><S><S><W><E><Q><E><S><A><Q><H><E><D><G><R><D><S><E><A><C><R><Q><R><F><R><Q><F><C><Y><G><D><V><H><G><P><H><E><A><F><S><Q><L><W><E><L><C><C><R><W><L><R><P><E><L><R><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><V><L><P><G><E><I><Q><G><W><V><R><E><Q><H><P><G><S><G><E><E><A><V><A><L><V><E><D><L><Q><K><Q><P><V><K><A><W><R><Q><D><V><P><S><E><E><A><E><P><E><A><A><G><R><G><S><Q><A><T><G><P><P><P><T><V><G><A><R><R><R><P><S><V><P><Q><E><Q><H><S><H><S><A><Q><P><P><A><L><L><K><E><G><R><P><G><E><T><T><D><T><C><F><V><S><G><V><H><G><P><V><A><L><G><D><I><P><F><Y><F><S><R><E><E><W><G><T><L><D><P><A><Q><R><D><L><F><W><D><I><K><R><E><N><S><R><N><T><T><L><G><F><G><L><K><G><Q><S><E><K><S><L><L><Q><E><M><V><P><V><V><P><G><Q><T><G><S><D><V><T><V><S><W><S><P><E><E><A><E><A><W><E><S><E><N><R><P><R><A><A><L><G><P><V><V><G><A><R><R><G><R><P><P><T><R><R><R><Q><F><R><D><L><A><A><E><K><P><H><S><C><G><Q><C><G><K><R><F><R><W><G><S><D><L><A><R><H><Q><R><T><H><T><G><E><K><P><H><K><C><P><E><C><D><K><S><F><R><S><S><S><D><L><V><R><H><Q><G><V><H><T><G><E><K><P><F><S><C><S><E><C><G><K><S><F><S><R><S><A><Y><L><A><D><H><Q><R><I><H><T><G><E><K><P><F><G><C><S><D><C><G><K><S><F><S><L><R><S><Y><L><L><D><H><R><R><V><H><T><G><E><R><P><F><G><C><G><E><C><D><K><S><F><K><Q><R><A><H><L><I><A><H><Q><S><L><H><A><K><M><A><Q><P><V><G>
May be involved in transcriptional regulation.<BOP>
O14771
Q96D42
HAVR1_HUMAN
T-cell membrane protein 1
Homo
<M><H><P><Q><V><V><I><L><S><L><I><L><H><L><A><D><S><V><A><G><S><V><K><V><G><G><E><A><G><P><S><V><T><L><P><C><H><Y><S><G><A><V><T><S><M><C><W><N><R><G><S><C><S><L><F><T><C><Q><N><G><I><V><W><T><N><G><T><H><V><T><Y><R><K><D><T><R><Y><K><L><L><G><D><L><S><R><R><D><V><S><L><T><I><E><N><T><A><V><S><D><S><G><V><Y><C><C><R><V><E><H><R><G><W><F><N><D><M><K><I><T><V><S><L><E><I><V><P><P><K><V><T><T><T><P><I><V><T><T><V><P><T><V><T><T><V><R><T><S><T><T><V><P><T><T><T><T><V><P><M><T><T><V><P><T><T><T><V><P><T><T><M><S><I><P><T><T><T><T><V><L><T><T><M><T><V><S><T><T><T><S><V><P><T><T><T><S><I><P><T><T><T><S><V><P><V><T><T><T><V><S><T><F><V><P><P><M><P><L><P><R><Q><N><H><E><P><V><A><T><S><P><S><S><P><Q><P><A><E><T><H><P><T><T><L><Q><G><A><I><R><R><E><P><T><S><S><P><L><Y><S><Y><T><T><D><G><N><D><T><V><T><E><S><S><D><G><L><W><N><N><N><Q><T><Q><L><F><L><E><H><S><L><L><T><A><N><T><T><K><G><I><Y><A><G><V><C><I><S><V><L><V><L><L><A><L><L><G><V><I><I><A><K><K><Y><F><F><K><K><E><V><Q><Q><L><S><V><S><F><S><S><L><Q><I><K><A><L><Q><N><A><V><E><K><E><V><Q><A><E><D><N><I><Y><I><E><N><S><L><Y><A><T><D>
(Microbial infection) Plays a positive role in Chikungunya virus cell entry.<BOP>
Q96D42
Q96AC1
FERM2_HUMAN
Pleckstrin homology domain-containing family C member 1
Homo
<M><A><L><D><G><I><R><M><P><D><G><C><Y><A><D><G><T><W><E><L><S><V><H><V><T><D><L><N><R><D><V><T><L><R><V><T><G><E><V><H><I><G><G><V><M><L><K><L><V><E><K><L><D><V><K><K><D><W><S><D><H><A><L><W><W><E><K><K><R><T><W><L><L><K><T><H><W><T><L><D><K><Y><G><I><Q><A><D><A><K><L><Q><F><T><P><Q><H><K><L><L><R><L><Q><L><P><N><M><K><Y><V><K><V><K><V><N><F><S><D><R><V><F><K><A><V><S><D><I><C><K><T><F><N><I><R><H><P><E><E><L><S><L><L><K><K><P><R><D><P><T><K><K><K><K><K><K><L><D><D><Q><S><E><D><E><A><L><E><L><E><G><P><L><I><T><P><G><S><G><S><I><Y><S><S><P><G><L><Y><S><K><T><M><T><P><T><Y><D><A><H><D><G><S><P><L><S><P><T><S><A><W><F><G><D><S><A><L><S><E><G><N><P><G><I><L><A><V><S><Q><P><I><T><S><P><E><I><L><A><K><M><F><K><P><Q><A><L><L><D><K><A><K><I><N><Q><G><W><L><D><S><S><R><S><L><M><E><Q><D><V><K><E><N><E><A><L><L><L><R><F><K><Y><Y><S><F><F><D><L><N><P><K><Y><D><A><I><R><I><N><Q><L><Y><E><Q><A><K><W><A><I><L><L><E><E><I><E><C><T><E><E><E><M><M><M><F><A><A><L><Q><Y><H><I><N><K><L><S><I><M><T><S><E><N><H><L><N><N><S><D><K><E><V><D><E><V><D><A><A><L><S><D><L><E><I><T><L><E><G><G><K><T><S><T><I><L><G><D><I><T><S><I><P><E><L><A><D><Y><I><K><V><F><K><P><K><K><L><T><L><K><G><Y><K><Q><Y><W><C><T><F><K><D><T><S><I><S><C><Y><K><S><K><E><E><S><S><G><T><P><A><H><Q><M><N><L><R><G><C><E><V><T><P><D><V><N><I><S><G><Q><K><F><N><I><K><L><L><I><P><V><A><E><G><M><N><E><I><W><L><R><C><D><N><E><K><Q><Y><A><H><W><M><A><A><C><R><L><A><S><K><G><K><T><M><A><D><S><S><Y><N><L><E><V><Q><N><I><L><S><F><L><K><M><Q><H><L><N><P><D><P><Q><L><I><P><E><Q><I><T><T><D><I><T><P><E><C><L><V><S><P><R><Y><L><K><K><Y><K><N><K><Q><I><T><A><R><I><L><E><A><H><Q><N><V><A><Q><M><S><L><I><E><A><K><M><R><F><I><Q><A><W><Q><S><L><P><E><F><G><I><T><H><F><I><A><R><F><Q><G><G><K><K><E><E><L><I><G><I><A><Y><N><R><L><I><R><M><D><A><S><T><G><D><A><I><K><T><W><R><F><S><N><M><K><Q><W><N><V><N><W><E><I><K><M><V><T><V><E><F><A><D><E><V><R><L><S><F><I><C><T><E><V><D><C><K><V><V><H><E><F><I><G><G><Y><I><F><L><S><T><R><A><K><D><Q><N><E><S><L><D><E><E><M><F><Y><K><L><T><S><G><W><V>
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<BOP>
Q96AC1
P02724
GLPA_HUMAN
Sialoglycoprotein alpha
Homo
<M><Y><G><K><I><I><F><V><L><L><L><S><E><I><V><S><I><S><A><S><S><T><T><G><V><A><M><H><T><S><T><S><S><S><V><T><K><S><Y><I><S><S><Q><T><N><D><T><H><K><R><D><T><Y><A><A><T><P><R><A><H><E><V><S><E><I><S><V><R><T><V><Y><P><P><E><E><E><T><G><E><R><V><Q><L><A><H><H><F><S><E><P><E><I><T><L><I><I><F><G><V><M><A><G><V><I><G><T><I><L><L><I><S><Y><G><I><R><R><L><I><K><K><S><P><S><D><V><K><P><L><P><S><P><D><T><D><V><P><L><S><S><V><E><I><E><N><P><E><T><S><D><Q>
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).<BOP>
P02724
Q7Z4W1
DCXR_HUMAN
Sperm surface protein P34H
Homo
<M><E><L><F><L><A><G><R><R><V><L><V><T><G><A><G><K><G><I><G><R><G><T><V><Q><A><L><H><A><T><G><A><R><V><V><A><V><S><R><T><Q><A><D><L><D><S><L><V><R><E><C><P><G><I><E><P><V><C><V><D><L><G><D><W><E><A><T><E><R><A><L><G><S><V><G><P><V><D><L><L><V><N><N><A><A><V><A><L><L><Q><P><F><L><E><V><T><K><E><A><F><D><R><S><F><E><V><N><L><R><A><V><I><Q><V><S><Q><I><V><A><R><G><L><I><A><R><G><V><P><G><A><I><V><N><V><S><S><Q><C><S><Q><R><A><V><T><N><H><S><V><Y><C><S><T><K><G><A><L><D><M><L><T><K><V><M><A><L><E><L><G><P><H><K><I><R><V><N><A><V><N><P><T><V><V><M><T><S><M><G><Q><A><T><W><S><D><P><H><K><A><K><T><M><L><N><R><I><P><L><G><K><F><A><E><V><E><H><V><V><N><A><I><L><F><L><L><S><D><R><S><G><M><T><T><G><S><T><L><P><V><E><G><G><F><W><A><C>
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.<BOP>
Q7Z4W1