accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q7Z3V5
ZN571_HUMAN
Zinc finger protein 571
Homo
<M><P><H><L><L><V><T><F><R><D><V><A><I><D><F><S><Q><E><E><W><E><C><L><D><P><A><Q><R><D><L><Y><R><D><V><M><L><E><N><Y><S><N><L><I><S><L><D><L><E><S><S><C><V><T><K><K><L><S><P><E><K><E><I><Y><E><M><E><S><L><Q><W><E><N><M><G><K><R><I><N><H><H><L><Q><Y><N><G><L><G><D><N><M><E><C><K><G><N><L><E><G><Q><E><A><S><Q><E><G><L><Y><M><C><V><K><I><T><C><E><E><K><A><T><E><S><H><S><T><S><S><T><F><H><R><I><I><P><T><K><E><K><L><Y><K><C><K><E><C><R><Q><G><F><S><Y><L><S><C><L><I><Q><H><E><E><N><H><N><I><E><K><C><S><E><V><K><K><H><R><N><T><F><S><K><K><P><S><Y><I><Q><H><Q><R><I><Q><T><G><E><K><P><Y><E><C><M><E><C><G><K><A><F><G><R><T><S><D><L><I><Q><H><Q><K><I><H><T><N><E><K><P><Y><Q><C><N><A><C><G><K><A><F><I><R><G><S><Q><L><T><E><H><Q><R><V><H><T><G><E><K><P><Y><E><C><K><K><C><G><K><A><F><S><Y><C><S><Q><Y><T><L><H><Q><R><I><H><S><G><E><K><P><Y><E><C><K><D><C><G><K><A><F><I><L><G><S><Q><L><T><Y><H><Q><R><I><H><S><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><I><L><G><S><H><L><T><Y><H><Q><R><V><H><T><G><E><K><P><Y><I><C><K><E><C><G><K><A><F><L><C><A><S><Q><L><N><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><T><F><F><R><G><S><Q><L><T><Y><H><L><R><V><H><S><G><E><R><P><Y><K><C><K><E><C><G><K><A><F><I><S><N><S><N><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><I><C><G><K><Q><L><S><E><H><Q><R><I><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><I><R><V><A><Y><L><T><Q><H><E><K><I><H><G><E><K><H><Y><E><C><K><E><C><G><K><T><F><V><R><A><T><Q><L><T><Y><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><D><K><A><F><I><Y><G><S><Q><L><S><E><H><Q><R><I><H><R><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><I><R><G><S><H><L><T><E><H><L><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><R><A><F><S><R><G><S><E><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><T><C><V><Q><C><G><K><D><F><R><C><P><S><Q><L><T><Q><H><T><R><L><H><N>
May be involved in transcriptional regulation.<BOP>
Q7Z3V5
Q9Y275
TN13B_HUMAN
Tumor necrosis factor ligand superfamily member 13b, soluble form
Homo
<M><D><D><S><T><E><R><E><Q><S><R><L><T><S><C><L><K><K><R><E><E><M><K><L><K><E><C><V><S><I><L><P><R><K><E><S><P><S><V><R><S><S><K><D><G><K><L><L><A><A><T><L><L><L><A><L><L><S><C><C><L><T><V><V><S><F><Y><Q><V><A><A><L><Q><G><D><L><A><S><L><R><A><E><L><Q><G><H><H><A><E><K><L><P><A><G><A><G><A><P><K><A><G><L><E><E><A><P><A><V><T><A><G><L><K><I><F><E><P><P><A><P><G><E><G><N><S><S><Q><N><S><R><N><K><R><A><V><Q><G><P><E><E><T><V><T><Q><D><C><L><Q><L><I><A><D><S><E><T><P><T><I><Q><K><G><S><Y><T><F><V><P><W><L><L><S><F><K><R><G><S><A><L><E><E><K><E><N><K><I><L><V><K><E><T><G><Y><F><F><I><Y><G><Q><V><L><Y><T><D><K><T><Y><A><M><G><H><L><I><Q><R><K><K><V><H><V><F><G><D><E><L><S><L><V><T><L><F><R><C><I><Q><N><M><P><E><T><L><P><N><N><S><C><Y><S><A><G><I><A><K><L><E><E><G><D><E><L><Q><L><A><I><P><R><E><N><A><Q><I><S><L><D><G><D><V><T><F><F><G><A><L><K><L><L>
Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.<BOP>
Q9Y275
Q8IYK4
GT252_HUMAN
Hydroxylysine galactosyltransferase 2
Homo
<M><A><A><R><P><A><A><T><L><A><W><S><L><L><L><L><S><S><A><L><L><R><E><G><C><R><A><R><F><V><A><E><R><D><S><E><D><D><G><E><E><P><V><V><F><P><E><S><P><L><Q><S><P><T><V><L><V><A><V><L><A><R><N><A><A><H><T><L><P><H><F><L><G><C><L><E><R><L><D><Y><P><K><S><R><M><A><I><W><A><A><T><D><H><N><V><D><N><T><T><E><I><F><R><E><W><L><K><N><V><Q><R><L><Y><H><Y><V><E><W><R><P><M><D><E><P><E><S><Y><P><D><E><I><G><P><K><H><W><P><T><S><R><F><A><H><V><M><K><L><R><Q><A><A><L><R><T><A><R><E><K><W><S><D><Y><I><L><F><I><D><V><D><N><F><L><T><N><P><Q><T><L><N><L><L><I><A><E><N><K><T><I><V><A><P><M><L><E><S><R><G><L><Y><S><N><F><W><C><G><I><T><P><K><G><F><Y><K><R><T><P><D><Y><V><Q><I><R><E><W><K><R><T><G><C><F><P><V><P><M><V><H><S><T><F><L><I><D><L><R><K><E><A><S><D><K><L><T><F><Y><P><P><H><Q><D><Y><T><W><T><F><D><D><I><I><V><F><A><F><S><S><R><Q><A><G><I><Q><M><Y><L><C><N><R><E><H><Y><G><Y><L><P><I><P><L><K><P><H><Q><T><L><Q><E><D><I><E><N><L><I><H><V><Q><I><E><A><M><I><D><R><P><P><M><E><P><S><Q><Y><V><S><V><V><P><K><Y><P><D><K><M><G><F><D><E><I><F><M><I><N><L><K><R><R><K><D><R><R><D><R><M><L><R><T><L><Y><E><Q><E><I><E><V><K><I><V><E><A><V><D><G><K><A><L><N><T><S><Q><L><K><A><L><N><I><E><M><L><P><G><Y><R><D><P><Y><S><S><R><P><L><T><R><G><E><I><G><C><F><L><S><H><Y><S><V><W><K><E><V><I><D><R><E><L><E><K><T><L><V><I><E><D><D><V><R><F><E><H><Q><F><K><K><K><L><M><K><L><M><D><N><I><D><Q><A><Q><L><D><W><E><L><I><Y><I><G><R><K><R><M><Q><V><K><E><P><E><K><A><V><P><N><V><A><N><L><V><E><A><D><Y><S><Y><W><T><L><G><Y><V><I><S><L><E><G><A><Q><K><L><V><G><A><N><P><F><G><K><M><L><P><V><D><E><F><L><P><V><M><Y><N><K><H><P><V><A><E><Y><K><E><Y><Y><E><S><R><D><L><K><A><F><S><A><E><P><L><L><I><Y><P><T><H><Y><T><G><Q><P><G><Y><L><S><D><T><E><T><S><T><I><W><D><N><E><T><V><A><T><D><W><D><R><T><H><A><W><K><S><R><K><Q><S><R><I><Y><S><N><A><K><N><T><E><A><L><P><P><P><T><S><L><D><T><V><P><S><R><D><E><L>
Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen.<BOP>
Q8IYK4
Q9NRG9
AAAS_HUMAN
Adracalin
Homo
<M><C><S><L><G><L><F><P><P><P><P><P><R><G><Q><V><T><L><Y><E><H><N><N><E><L><V><T><G><S><S><Y><E><S><P><P><P><D><F><R><G><Q><W><I><N><L><P><V><L><Q><L><T><K><D><P><L><K><T><P><G><R><L><D><H><G><T><R><T><A><F><I><H><H><R><E><Q><V><W><K><R><C><I><N><I><W><R><D><V><G><L><F><G><V><L><N><E><I><A><N><S><E><E><E><V><F><E><W><V><K><T><A><S><G><W><A><L><A><L><C><R><W><A><S><S><L><H><G><S><L><F><P><H><L><S><L><R><S><E><D><L><I><A><E><F><A><Q><V><T><N><W><S><S><C><C><L><R><V><F><A><W><H><P><H><T><N><K><F><A><V><A><L><L><D><D><S><V><R><V><Y><N><A><S><S><T><I><V><P><S><L><K><H><R><L><Q><R><N><V><A><S><L><A><W><K><P><L><S><A><S><V><L><A><V><A><C><Q><S><C><I><L><I><W><T><L><D><P><T><S><L><S><T><R><P><S><S><G><C><A><Q><V><L><S><H><P><G><H><T><P><V><T><S><L><A><W><A><P><S><G><G><R><L><L><S><A><S><P><V><D><A><A><I><R><V><W><D><V><S><T><E><T><C><V><P><L><P><W><F><R><G><G><G><V><T><N><L><L><W><S><P><D><G><S><K><I><L><A><T><T><P><S><A><V><F><R><V><W><E><A><Q><M><W><T><C><E><R><W><P><T><L><S><G><R><C><Q><T><G><C><W><S><P><D><G><S><R><L><L><F><T><V><L><G><E><P><L><I><Y><S><L><S><F><P><E><R><C><G><E><G><K><G><C><V><G><G><A><K><S><A><T><I><V><A><D><L><S><E><T><T><I><Q><T><P><D><G><E><E><R><L><G><G><E><A><H><S><M><V><W><D><P><S><G><E><R><L><A><V><L><M><K><G><K><P><R><V><Q><D><G><K><P><V><I><L><L><F><R><T><R><N><S><P><V><F><E><L><L><P><C><G><I><I><Q><G><E><P><G><A><Q><P><Q><L><I><T><F><H><P><S><F><N><K><G><A><L><L><S><V><G><W><S><T><G><R><I><A><H><I><P><L><Y><F><V><N><A><Q><F><P><R><F><S><P><V><L><G><R><A><Q><E><P><P><A><G><G><G><G><S><I><H><D><L><P><L><F><T><E><T><S><P><T><S><A><P><W><D><P><L><P><G><P><P><P><V><L><P><H><S><P><H><S><H><L>
Plays a role in the normal development of the peripheral and central nervous system . Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment .<BOP>
Q9NRG9
O95500
CLD14_HUMAN
Claudin-14
Homo
<M><A><S><T><A><V><Q><L><L><G><F><L><L><S><F><L><G><M><V><G><T><L><I><T><T><I><L><P><H><W><R><R><T><A><H><V><G><T><N><I><L><T><A><V><S><Y><L><K><G><L><W><M><E><C><V><W><H><S><T><G><I><Y><Q><C><Q><I><Y><R><S><L><L><A><L><P><Q><D><L><Q><A><A><R><A><L><M><V><I><S><C><L><L><S><G><I><A><C><A><C><A><V><I><G><M><K><C><T><R><C><A><K><G><T><P><A><K><T><T><F><A><I><L><G><G><T><L><F><I><L><A><G><L><L><C><M><V><A><V><S><W><T><T><N><D><V><V><Q><N><F><Y><N><P><L><L><P><S><G><M><K><F><E><I><G><Q><A><L><Y><L><G><F><I><S><S><S><L><S><L><I><G><G><T><L><L><C><L><S><C><Q><D><E><A><P><Y><R><P><Y><Q><A><P><P><R><A><T><T><T><T><A><N><T><A><P><A><Y><Q><P><P><A><A><Y><K><D><N><R><A><P><S><V><T><S><A><T><H><S><G><Y><R><L><N><D><Y><V>
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<BOP>
O95500
P11686
PSPC_HUMAN
SP5
Homo
<M><D><V><G><S><K><E><V><L><M><E><S><P><P><D><Y><S><A><A><P><R><G><R><F><G><I><P><C><C><P><V><H><L><K><R><L><L><I><V><V><V><V><V><V><L><I><V><V><V><I><V><G><A><L><L><M><G><L><H><M><S><Q><K><H><T><E><M><V><L><E><M><S><I><G><A><P><E><A><Q><Q><R><L><A><L><S><E><H><L><V><T><T><A><T><F><S><I><G><S><T><G><L><V><V><Y><D><Y><Q><Q><L><L><I><A><Y><K><P><A><P><G><T><C><C><Y><I><M><K><I><A><P><E><S><I><P><S><L><E><A><L><N><R><K><V><H><N><F><Q><M><E><C><S><L><Q><A><K><P><A><V><P><T><S><K><L><G><Q><A><E><G><R><D><A><G><S><A><P><S><G><G><D><P><A><F><L><G><M><A><V><N><T><L><C><G><E><V><P><L><Y><Y><I>
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.<BOP>
P11686
Q495M3
S36A2_HUMAN
Transmembrane domain rich protein 1
Homo
<M><S><V><T><K><S><T><E><G><P><Q><G><A><V><A><I><K><L><D><L><M><S><P><P><E><S><A><K><K><L><E><N><K><D><S><T><F><L><D><E><S><P><S><E><S><A><G><L><K><K><T><K><G><I><T><V><F><Q><A><L><I><H><L><V><K><G><N><M><G><T><G><I><L><G><L><P><L><A><V><K><N><A><G><I><L><M><G><P><L><S><L><L><V><M><G><F><I><A><C><H><C><M><H><I><L><V><K><C><A><Q><R><F><C><K><R><L><N><K><P><F><M><D><Y><G><D><T><V><M><H><G><L><E><A><N><P><N><A><W><L><Q><N><H><A><H><W><G><R><H><I><V><S><F><F><L><I><I><T><Q><L><G><F><C><C><V><Y><I><V><F><L><A><D><N><L><K><Q><V><V><E><A><V><N><S><T><T><N><N><C><Y><S><N><E><T><V><I><L><T><P><T><M><D><S><R><L><Y><M><L><S><F><L><P><F><L><V><L><L><V><L><I><R><N><L><R><I><L><T><I><F><S><M><L><A><N><I><S><M><L><V><S><L><V><I><I><I><Q><Y><I><T><Q><E><I><P><D><P><S><R><L><P><L><V><A><S><W><K><T><Y><P><L><F><F><G><T><A><I><F><S><F><E><S><I><G><V><V><L><P><L><E><N><K><M><K><N><A><R><H><F><P><A><I><L><S><L><G><M><S><I><V><T><S><L><Y><I><G><M><A><A><L><G><Y><L><R><F><G><D><D><I><K><A><S><I><S><L><N><L><P><N><C><W><L><Y><Q><S><V><K><L><L><Y><I><A><G><I><L><C><T><Y><A><L><Q><F><Y><V><P><A><E><I><I><I><P><F><A><I><S><R><V><S><T><R><W><A><L><P><L><D><L><S><I><R><L><V><M><V><C><L><T><C><L><L><A><I><L><I><P><R><L><D><L><V><I><S><L><V><G><S><V><S><G><T><A><L><A><L><I><I><P><P><L><L><E><V><T><T><F><Y><S><E><G><M><S><P><L><T><I><F><K><D><A><L><I><S><I><L><G><F><V><G><F><V><V><G><T><Y><Q><A><L><D><E><L><L><K><S><E><D><S><H><P><F><S><N><S><T><T><F><V><R>
Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred.<BOP>
Q495M3
Q99972
MYOC_HUMAN
Myocilin 35 kDa N-terminal fragment
Homo
<M><R><F><F><C><A><R><C><C><S><F><G><P><E><M><P><A><V><Q><L><L><L><L><A><C><L><V><W><D><V><G><A><R><T><A><Q><L><R><K><A><N><D><Q><S><G><R><C><Q><Y><T><F><S><V><A><S><P><N><E><S><S><C><P><E><Q><S><Q><A><M><S><V><I><H><N><L><Q><R><D><S><S><T><Q><R><L><D><L><E><A><T><K><A><R><L><S><S><L><E><S><L><L><H><Q><L><T><L><D><Q><A><A><R><P><Q><E><T><Q><E><G><L><Q><R><E><L><G><T><L><R><R><E><R><D><Q><L><E><T><Q><T><R><E><L><E><T><A><Y><S><N><L><L><R><D><K><S><V><L><E><E><E><K><K><R><L><R><Q><E><N><E><N><L><A><R><R><L><E><S><S><S><Q><E><V><A><R><L><R><R><G><Q><C><P><Q><T><R><D><T><A><R><A><V><P><P><G><S><R><E><V><S><T><W><N><L><D><T><L><A><F><Q><E><L><K><S><E><L><T><E><V><P><A><S><R><I><L><K><E><S><P><S><G><Y><L><R><S><G><E><G><D><T><G><C><G><E><L><V><W><V><G><E><P><L><T><L><R><T><A><E><T><I><T><G><K><Y><G><V><W><M><R><D><P><K><P><T><Y><P><Y><T><Q><E><T><T><W><R><I><D><T><V><G><T><D><V><R><Q><V><F><E><Y><D><L><I><S><Q><F><M><Q><G><Y><P><S><K><V><H><I><L><P><R><P><L><E><S><T><G><A><V><V><Y><S><G><S><L><Y><F><Q><G><A><E><S><R><T><V><I><R><Y><E><L><N><T><E><T><V><K><A><E><K><E><I><P><G><A><G><Y><H><G><Q><F><P><Y><S><W><G><G><Y><T><D><I><D><L><A><V><D><E><A><G><L><W><V><I><Y><S><T><D><E><A><K><G><A><I><V><L><S><K><L><N><P><E><N><L><E><L><E><Q><T><W><E><T><N><I><R><K><Q><S><V><A><N><A><F><I><I><C><G><T><L><Y><T><V><S><S><Y><T><S><A><D><A><T><V><N><F><A><Y><D><T><G><T><G><I><S><K><T><L><T><I><P><F><K><N><R><Y><K><Y><S><S><M><I><D><Y><N><P><L><E><K><K><L><F><A><W><D><N><L><N><M><V><T><Y><D><I><K><L><S><K><M>
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.<BOP>
Q99972
Q9Y234
LIPT_HUMAN
Lipoyl ligase
Homo
<M><L><I><P><F><S><M><K><N><C><F><Q><L><L><C><N><C><Q><V><P><A><A><G><F><K><K><T><V><K><N><G><L><I><L><Q><S><I><S><N><D><V><Y><Q><N><L><A><V><E><D><W><I><H><D><H><M><N><L><E><G><K><P><I><L><F><F><W><Q><N><S><P><S><V><V><I><G><R><H><Q><N><P><W><Q><E><C><N><L><N><L><M><R><E><E><G><I><K><L><A><R><R><R><S><G><G><G><T><V><Y><H><D><M><G><N><I><N><L><T><F><F><T><T><K><K><K><Y><D><R><M><E><N><L><K><L><I><V><R><A><L><N><A><V><Q><P><Q><L><D><V><Q><A><T><K><R><F><D><L><L><L><D><G><Q><F><K><I><S><G><T><A><S><K><I><G><R><T><T><A><Y><H><H><C><T><L><L><C><S><T><D><G><T><F><L><S><S><L><L><K><S><P><Y><Q><G><I><R><S><N><A><T><A><S><I><P><S><L><V><K><N><L><L><E><K><D><P><T><L><T><C><E><V><L><M><N><A><V><A><T><E><Y><A><A><Y><H><Q><I><D><N><H><I><H><L><I><N><P><T><D><E><T><L><F><P><G><I><N><S><K><A><K><E><L><Q><T><W><E><W><I><Y><G><K><T><P><K><F><S><I><N><T><S><F><H><V><L><Y><E><Q><S><H><L><E><I><K><V><F><I><D><I><K><N><G><R><I><E><I><C><N><I><E><A><P><D><H><W><L><P><L><E><I><R><D><K><L><N><S><S><L><I><G><S><K><F><C><P><T><E><T><T><M><L><T><N><I><L><L><R><T><C><P><Q><D><H><K><L><N><S><K><W><N><I><L><C><E><K><I><K><G><I><M>
Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.<BOP>
Q9Y234
P48544
KCNJ5_HUMAN
Potassium channel, inwardly rectifying subfamily J member 5
Homo
<M><A><G><D><S><R><N><A><M><N><Q><D><M><E><I><G><V><T><P><W><D><P><K><K><I><P><K><Q><A><R><D><Y><V><P><I><A><T><D><R><T><R><L><L><A><E><G><K><K><P><R><Q><R><Y><M><E><K><S><G><K><C><N><V><H><H><G><N><V><Q><E><T><Y><R><Y><L><S><D><L><F><T><T><L><V><D><L><K><W><R><F><N><L><L><V><F><T><M><V><Y><T><V><T><W><L><F><F><G><F><I><W><W><L><I><A><Y><I><R><G><D><L><D><H><V><G><D><Q><E><W><I><P><C><V><E><N><L><S><G><F><V><S><A><F><L><F><S><I><E><T><E><T><T><I><G><Y><G><F><R><V><I><T><E><K><C><P><E><G><I><I><L><L><L><V><Q><A><I><L><G><S><I><V><N><A><F><M><V><G><C><M><F><V><K><I><S><Q><P><K><K><R><A><E><T><L><M><F><S><N><N><A><V><I><S><M><R><D><E><K><L><C><L><M><F><R><V><G><D><L><R><N><S><H><I><V><E><A><S><I><R><A><K><L><I><K><S><R><Q><T><K><E><G><E><F><I><P><L><N><Q><T><D><I><N><V><G><F><D><T><G><D><D><R><L><F><L><V><S><P><L><I><I><S><H><E><I><N><Q><K><S><P><F><W><E><M><S><Q><A><Q><L><H><Q><E><E><F><E><V><V><V><I><L><E><G><M><V><E><A><T><G><M><T><C><Q><A><R><S><S><Y><M><D><T><E><V><L><W><G><H><R><F><T><P><V><L><T><L><E><K><G><F><Y><E><V><D><Y><N><T><F><H><D><T><Y><E><T><N><T><P><S><C><C><A><K><E><L><A><E><M><K><R><E><G><R><L><L><Q><Y><L><P><S><P><P><L><L><G><G><C><A><E><A><G><L><D><A><E><A><E><Q><N><E><E><D><E><P><K><G><L><G><G><S><R><E><A><R><G><S><V>
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.<BOP>
P48544
Q9Y2U2
KCNK7_HUMAN
Potassium channel subfamily K member 7
Homo
<M><G><G><L><R><P><W><S><R><Y><G><L><L><V><V><A><H><L><L><A><L><G><L><G><A><V><V><F><Q><A><L><E><G><P><P><A><C><R><L><Q><A><E><L><R><A><E><L><A><A><F><Q><A><E><H><R><A><C><L><P><P><G><A><L><E><E><L><L><G><T><A><L><A><T><Q><A><H><G><V><S><T><L><G><N><S><S><E><G><R><T><W><D><L><P><S><A><L><L><F><A><A><S><I><L><T><T><T><G><Y><G><H><M><A><P><L><S><P><G><G><K><A><F><C><M><V><Y><A><A><L><G><L><P><A><S><L><A><L><V><A><T><L><R><H><C><L><L><P><V><L><S><R><P><R><A><W><V><A><V><H><W><Q><L><S><P><A><R><A><A><L><L><Q><A><V><A><L><G><L><L><V><A><S><S><F><V><L><L><P><A><L><V><L><W><G><L><Q><G><D><C><S><L><L><G><A><V><Y><F><C><F><S><S><L><S><T><I><G><L><E><D><L><L><P><G><R><G><R><S><L><H><P><V><I><Y><H><L><G><Q><L><A><L><L><G><Y><L><L><L><G><L><L><A><M><L><L><A><V><E><T><F><S><E><L><P><Q><V><R><A><M><G><K><F><F><R><P><S><G><P><V><T><A><E><D><Q><G><G><I><L><G><Q><D><E><L><A><L><S><T><L><P><P><A><A><P><A><S><G><Q><A><P><A><C>
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.<BOP>
Q9Y2U2
Q02040
AK17A_HUMAN
Splicing factor, arginine/serine-rich 17A
Homo
<M><A><A><A><T><I><V><H><D><T><S><E><A><V><E><L><C><P><A><Y><G><L><Y><L><K><P><I><T><K><M><T><I><S><V><A><L><P><Q><L><K><Q><P><G><K><S><I><S><N><W><E><V><M><E><R><L><K><G><M><V><Q><N><H><Q><F><S><T><L><R><I><S><K><S><T><M><D><F><I><R><F><E><G><E><V><E><N><K><S><L><V><K><S><F><L><A><C><L><D><G><K><T><I><K><L><S><G><F><S><D><I><L><K><V><R><A><A><E><F><K><I><D><F><P><T><R><H><D><W><D><S><F><F><R><D><A><K><D><M><N><E><T><L><P><G><E><R><P><D><T><I><H><L><E><G><L><P><C><K><W><F><A><L><K><E><S><G><S><E><K><P><S><E><D><V><L><V><K><V><F><E><K><F><G><E><I><R><N><V><D><I><P><M><L><D><P><Y><R><E><E><M><T><G><R><N><F><H><T><F><S><F><G><G><H><L><N><F><E><A><Y><V><Q><Y><R><E><Y><M><G><F><I><Q><A><M><S><A><L><R><G><M><K><L><M><Y><K><G><E><D><G><K><A><V><A><C><N><I><K><V><S><F><D><S><T><K><H><L><S><D><A><S><I><K><K><R><Q><L><E><R><Q><K><L><Q><E><L><E><Q><Q><R><E><E><Q><K><R><R><E><K><E><A><E><E><R><Q><R><A><E><E><R><K><Q><K><E><L><E><E><L><E><R><E><R><K><R><E><E><K><L><R><K><R><E><Q><K><Q><R><D><R><E><L><R><R><N><Q><K><K><L><E><K><L><Q><A><E><E><Q><K><Q><L><Q><E><K><I><K><L><E><E><R><K><L><L><L><A><Q><R><N><L><Q><S><I><R><L><I><A><E><L><L><S><R><A><K><A><V><K><L><R><E><Q><E><Q><K><E><E><K><L><R><L><Q><Q><Q><E><E><R><R><R><L><Q><E><A><E><L><R><R><V><E><E><E><K><E><R><A><L><G><L><Q><R><K><E><R><E><L><R><E><R><L><L><S><I><L><L><S><K><K><P><D><D><S><H><T><H><D><E><L><G><V><A><H><A><D><L><L><Q><P><V><L><D><I><L><Q><T><V><S><S><G><C><V><S><A><T><T><L><H><P><L><G><G><Q><P><P><A><G><A><P><K><E><S><P><A><H><P><E><A><D><G><A><P><K><S><V><N><G><S><V><A><E><E><A><P><C><K><E><V><Q><S><S><C><R><V><V><P><E><D><G><S><P><E><K><R><C><P><G><G><V><L><S><C><I><P><D><N><N><Q><Q><P><K><G><I><P><A><C><E><Q><N><V><S><R><K><D><T><R><S><E><Q><D><K><C><N><R><E><P><S><K><G><R><G><R><A><T><G><D><G><L><A><D><R><H><K><R><E><R><S><R><A><R><R><A><S><S><R><E><D><G><R><P><R><K><E><R><R><P><H><K><K><H><A><Y><K><D><D><S><P><R><R><R><S><T><S><P><D><H><T><R><S><R><R><S><H><S><K><D><R><H><R><R><E><R><S><R><E><R><R><G><S><A><S><R><K><H><S><R><H><R><R><R><S><E><R><S><R><S><R><S><P><S><R><H><R><S><T><W><N><R>
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.<BOP>
Q02040
Q8TAG5
VTM2A_HUMAN
V-set and transmembrane domain-containing protein 2A
Homo
<M><M><G><I><F><L><V><Y><V><G><F><V><F><F><S><V><L><Y><V><Q><Q><G><L><S><S><Q><A><K><F><T><E><F><P><R><N><V><T><A><T><E><G><Q><N><V><E><M><S><C><A><F><Q><S><G><S><A><S><V><Y><L><E><I><Q><W><W><F><L><R><G><P><E><D><L><D><P><G><A><E><G><A><G><A><Q><V><E><L><L><P><D><R><D><P><D><S><D><G><T><K><I><S><T><V><K><V><Q><G><N><D><I><S><H><K><L><Q><I><S><K><V><R><K><K><D><E><G><L><Y><E><C><R><V><T><D><A><N><Y><G><E><L><Q><E><H><K><A><Q><A><Y><L><K><V><N><A><N><S><H><A><R><R><M><Q><A><F><E><A><S><P><M><W><L><Q><D><M><K><P><R><K><N><V><S><A><A><I><P><S><S><I><H><G><S><A><N><Q><R><T><H><S><T><S><S><P><Q><V><V><A><K><I><P><K><Q><S><P><Q><S><G><A><R><I><A><T><S><H><G><L><S><V><L><L><L><V><C><G><F><V><K><G><A><L><L>
Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.<BOP>
Q8TAG5
P32247
BRS3_HUMAN
Bombesin receptor subtype-3
Homo
<M><A><Q><R><Q><P><H><S><P><N><Q><T><L><I><S><I><T><N><D><T><E><S><S><S><S><V><V><S><N><D><N><T><N><K><G><W><S><G><D><N><S><P><G><I><E><A><L><C><A><I><Y><I><T><Y><A><V><I><I><S><V><G><I><L><G><N><A><I><L><I><K><V><F><F><K><T><K><S><M><Q><T><V><P><N><I><F><I><T><S><L><A><F><G><D><L><L><L><L><L><T><C><V><P><V><D><A><T><H><Y><L><A><E><G><W><L><F><G><R><I><G><C><K><V><L><S><F><I><R><L><T><S><V><G><V><S><V><F><T><L><T><I><L><S><A><D><R><Y><K><A><V><V><K><P><L><E><R><Q><P><S><N><A><I><L><K><T><C><V><K><A><G><C><V><W><I><V><S><M><I><F><A><L><P><E><A><I><F><S><N><V><Y><T><F><R><D><P><N><K><N><M><T><F><E><S><C><T><S><Y><P><V><S><K><K><L><L><Q><E><I><H><S><L><L><C><F><L><V><F><Y><I><I><P><L><S><I><I><S><V><Y><Y><S><L><I><A><R><T><L><Y><K><S><T><L><N><I><P><T><E><E><Q><S><H><A><R><K><Q><I><E><S><R><K><R><I><A><R><T><V><L><V><L><V><A><L><F><A><L><C><W><L><P><N><H><L><L><Y><L><Y><H><S><F><T><S><Q><T><Y><V><D><P><S><A><M><H><F><I><F><T><I><F><S><R><V><L><A><F><S><N><S><C><V><N><P><F><A><L><Y><W><L><S><K><S><F><Q><K><H><F><K><A><Q><L><F><C><C><K><A><E><R><P><E><P><P><V><A><D><T><S><L><T><T><L><A><V><M><G><T><V><P><G><T><G><S><I><Q><M><S><E><I><S><V><T><S><F><T><G><C><S><V><K><Q><A><E><D><R><F>
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<BOP>
P32247
Q9UBU9
NXF1_HUMAN
mRNA export factor TAP
Homo
<M><A><D><E><G><K><S><Y><S><E><H><D><D><E><R><V><N><F><P><Q><R><K><K><K><G><R><G><P><F><R><W><K><Y><G><E><G><N><R><R><S><G><R><G><G><S><G><I><R><S><S><R><L><E><E><D><D><G><D><V><A><M><S><D><A><Q><D><G><P><R><V><R><Y><N><P><Y><T><T><R><P><N><R><R><G><D><T><W><H><D><R><D><R><I><H><V><T><V><R><R><D><R><A><P><P><E><R><G><G><A><G><T><S><Q><D><G><T><S><K><N><W><F><K><I><T><I><P><Y><G><R><K><Y><D><K><A><W><L><L><S><M><I><Q><S><K><C><S><V><P><F><T><P><I><E><F><H><Y><E><N><T><R><A><Q><F><F><V><E><D><A><S><T><A><S><A><L><K><A><V><N><Y><K><I><L><D><R><E><N><R><R><I><S><I><I><I><N><S><S><A><P><P><H><T><I><L><N><E><L><K><P><E><Q><V><E><Q><L><K><L><I><M><S><K><R><Y><D><G><S><Q><Q><A><L><D><L><K><G><L><R><S><D><P><D><L><V><A><Q><N><I><D><V><V><L><N><R><R><S><C><M><A><A><T><L><R><I><I><E><E><N><I><P><E><L><L><S><L><N><L><S><N><N><R><L><Y><R><L><D><D><M><S><S><I><V><Q><K><A><P><N><L><K><I><L><N><L><S><G><N><E><L><K><S><E><R><E><L><D><K><I><K><G><L><K><L><E><E><L><W><L><D><G><N><S><L><C><D><T><F><R><D><Q><S><T><Y><I><S><A><I><R><E><R><F><P><K><L><L><R><L><D><G><H><E><L><P><P><P><I><A><F><D><V><E><A><P><T><T><L><P><P><C><K><G><S><Y><F><G><T><E><N><L><K><S><L><V><L><H><F><L><Q><Q><Y><Y><A><I><Y><D><S><G><D><R><Q><G><L><L><D><A><Y><H><D><G><A><C><C><S><L><S><I><P><F><I><P><Q><N><P><A><R><S><S><L><A><E><Y><F><K><D><S><R><N><V><K><K><L><K><D><P><T><L><R><F><R><L><L><K><H><T><R><L><N><V><V><A><F><L><N><E><L><P><K><T><Q><H><D><V><N><S><F><V><V><D><I><S><A><Q><T><S><T><L><L><C><F><S><V><N><G><V><F><K><E><V><D><G><K><S><R><D><S><L><R><A><F><T><R><T><F><I><A><V><P><A><S><N><S><G><L><C><I><V><N><D><E><L><F><V><R><N><A><S><S><E><E><I><Q><R><A><F><A><M><P><A><P><T><P><S><S><S><P><V><P><T><L><S><P><E><Q><Q><E><M><L><Q><A><F><S><T><Q><S><G><M><N><L><E><W><S><Q><K><C><L><Q><D><N><N><W><D><Y><T><R><S><A><Q><A><F><T><H><L><K><A><K><G><E><I><P><E><V><A><F><M><K>
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) . The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex . ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export . Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export .<BOP>
Q9UBU9
P78348
ASIC1_HUMAN
Brain sodium channel 2
Homo
<M><E><L><K><A><E><E><E><E><V><G><G><V><Q><P><V><S><I><Q><A><F><A><S><S><S><T><L><H><G><L><A><H><I><F><S><Y><E><R><L><S><L><K><R><A><L><W><A><L><C><F><L><G><S><L><A><V><L><L><C><V><C><T><E><R><V><Q><Y><Y><F><H><Y><H><H><V><T><K><L><D><E><V><A><A><S><Q><L><T><F><P><A><V><T><L><C><N><L><N><E><F><R><F><S><Q><V><S><K><N><D><L><Y><H><A><G><E><L><L><A><L><L><N><N><R><Y><E><I><P><D><T><Q><M><A><D><E><K><Q><L><E><I><L><Q><D><K><A><N><F><R><S><F><K><P><K><P><F><N><M><R><E><F><Y><D><R><A><G><H><D><I><R><D><M><L><L><S><C><H><F><R><G><E><V><C><S><A><E><D><F><K><V><V><F><T><R><Y><G><K><C><Y><T><F><N><S><G><R><D><G><R><P><R><L><K><T><M><K><G><G><T><G><N><G><L><E><I><M><L><D><I><Q><Q><D><E><Y><L><P><V><W><G><E><T><D><E><T><S><F><E><A><G><I><K><V><Q><I><H><S><Q><D><E><P><P><F><I><D><Q><L><G><F><G><V><A><P><G><F><Q><T><F><V><A><C><Q><E><Q><R><L><I><Y><L><P><P><P><W><G><T><C><K><A><V><T><M><D><S><D><L><D><F><F><D><S><Y><S><I><T><A><C><R><I><D><C><E><T><R><Y><L><V><E><N><C><N><C><R><M><V><H><M><P><G><D><A><P><Y><C><T><P><E><Q><Y><K><E><C><A><D><P><A><L><D><F><L><V><E><K><D><Q><E><Y><C><V><C><E><M><P><C><N><L><T><R><Y><G><K><E><L><S><M><V><K><I><P><S><K><A><S><A><K><Y><L><A><K><K><F><N><K><S><E><Q><Y><I><G><E><N><I><L><V><L><D><I><F><F><E><V><L><N><Y><E><T><I><E><Q><K><K><A><Y><E><I><A><G><L><L><G><D><I><G><G><Q><M><G><L><F><I><G><A><S><I><L><T><V><L><E><L><F><D><Y><A><Y><E><V><I><K><H><K><L><C><R><R><G><K><C><Q><K><E><A><K><R><S><S><A><D><K><G><V><A><L><S><L><D><D><V><K><R><H><N><P><C><E><S><L><R><G><H><P><A><G><M><T><Y><A><A><N><I><L><P><H><H><P><A><R><G><T><F><E><D><F><T><C>
Isoform 1 does not display proton-gated cation channel activity.<BOP>
P78348
Q5UCC4
EMC10_HUMAN
Hematopoietic signal peptide-containing membrane domain-containing protein 1
Homo
<M><A><A><A><S><A><G><A><T><R><L><L><L><L><L><L><M><A><V><A><A><P><S><R><A><R><G><S><G><C><R><A><G><T><G><A><R><G><A><G><A><E><G><R><E><G><E><A><C><G><T><V><G><L><L><L><E><H><S><F><E><I><D><D><S><A><N><F><R><K><R><G><S><L><L><W><N><Q><Q><D><G><T><L><S><L><S><Q><R><Q><L><S><E><E><E><R><G><R><L><R><D><V><A><A><L><N><G><L><Y><R><V><R><I><P><R><R><P><G><A><L><D><G><L><E><A><G><G><Y><V><S><S><F><V><P><A><C><S><L><V><E><S><H><L><S><D><Q><L><T><L><H><V><D><V><A><G><N><V><V><G><V><S><V><V><T><H><P><G><G><C><R><G><H><E><V><E><D><V><D><L><E><L><F><N><T><S><V><Q><L><Q><P><P><T><T><A><P><G><P><E><T><A><A><F><I><E><R><L><E><M><E><Q><A><Q><K><A><K><N><P><Q><E><Q><K><S><F><F><A><K><Y><W><M><Y><I><I><P><V><V><L><F><L><M><M><S><G><A><P><D><T><G><G><Q><G><G><G><G><G><G><G><G><G><G><G><S><G><R>
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways .<BOP>
Q5UCC4
Q9NPF4
OSGEP_HUMAN
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP
Homo
<M><P><A><V><L><G><F><E><G><S><A><N><K><I><G><V><G><V><V><R><D><G><K><V><L><A><N><P><R><R><T><Y><V><T><P><P><G><T><G><F><L><P><G><D><T><A><R><H><H><R><A><V><I><L><D><L><L><Q><E><A><L><T><E><S><G><L><T><S><Q><D><I><D><C><I><A><Y><T><K><G><P><G><M><G><A><P><L><V><S><V><A><V><V><A><R><T><V><A><Q><L><W><N><K><P><L><V><G><V><N><H><C><I><G><H><I><E><M><G><R><L><I><T><G><A><T><S><P><T><V><L><Y><V><S><G><G><N><T><Q><V><I><A><Y><S><E><H><R><Y><R><I><F><G><E><T><I><D><I><A><V><G><N><C><L><D><R><F><A><R><V><L><K><I><S><N><D><P><S><P><G><Y><N><I><E><Q><M><A><K><R><G><K><K><L><V><E><L><P><Y><T><V><K><G><M><D><V><S><F><S><G><I><L><S><F><I><E><D><V><A><H><R><M><L><A><T><G><E><C><T><P><E><D><L><C><F><S><L><Q><E><T><V><F><A><M><L><V><E><I><T><E><R><A><M><A><H><C><G><S><Q><E><A><L><I><V><G><G><V><G><C><N><V><R><L><Q><E><M><M><A><T><M><C><Q><E><R><G><A><R><L><F><A><T><D><E><R><F><C><I><D><N><G><A><M><I><A><Q><A><G><W><E><M><F><R><A><G><H><R><T><P><L><S><D><S><G><V><T><Q><R><Y><R><T><D><E><V><E><V><T><W><R><D>
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.<BOP>
Q9NPF4
Q8N162
OR8H2_HUMAN
Olfactory receptor OR11-171
Homo
<M><M><G><R><R><N><N><T><N><V><A><D><F><I><L><M><G><L><T><L><S><E><E><I><Q><M><A><L><F><M><L><F><L><L><I><Y><L><I><T><M><L><G><N><V><G><M><I><L><I><I><R><L><D><L><Q><L><H><T><P><M><Y><F><F><L><T><H><L><S><F><I><D><L><S><Y><S><T><V><V><T><P><K><T><L><A><N><L><L><T><S><N><Y><I><S><F><T><G><C><F><A><Q><M><F><F><F><A><F><L><G><T><A><E><C><Y><L><L><S><S><M><A><H><D><R><Y><A><A><I><C><S><P><L><H><Y><T><V><I><M><S><K><R><L><C><L><A><L><I><T><G><P><Y><V><I><G><F><I><D><S><F><V><N><V><V><S><M><S><R><L><H><F><Y><D><S><N><V><I><H><H><F><F><C><D><T><S><P><I><L><A><L><S><C><T><D><T><Y><N><T><E><I><L><I><F><I><I><V><G><S><T><L><M><V><S><L><F><T><I><S><A><S><Y><V><F><I><L><F><T><I><L><K><I><N><S><T><S><G><K><Q><K><A><F><S><T><C><V><S><H><L><L><G><V><T><I><F><Y><S><T><L><I><F><T><Y><L><K><P><R><K><S><Y><S><L><G><R><D><Q><V><A><S><V><F><Y><T><I><V><I><P><V><L><N><P><L><I><Y><S><L><R><N><K><E><V><K><N><A><V><I><R><V><M><Q><R><R><Q><D><S><R>
Odorant receptor.<BOP>
Q8N162
Q9UK99
FBX3_HUMAN
F-box only protein 3
Homo
<M><A><A><M><E><T><E><T><A><P><L><T><L><E><S><L><P><T><D><P><L><L><L><I><L><S><F><L><D><Y><R><D><L><I><N><C><C><Y><V><S><R><R><L><S><Q><L><S><S><H><D><P><L><W><R><R><H><C><K><K><Y><W><L><I><S><E><E><E><K><T><Q><K><N><Q><C><W><K><S><L><F><I><D><T><Y><S><D><V><G><R><Y><I><D><H><Y><A><A><I><K><K><A><W><D><D><L><K><K><Y><L><E><P><R><C><P><R><M><V><L><S><L><K><E><G><A><R><E><E><D><L><D><A><V><E><A><Q><I><G><C><K><L><P><D><D><Y><R><C><S><Y><R><I><H><N><G><Q><K><L><V><V><P><G><L><L><G><S><M><A><L><S><N><H><Y><R><S><E><D><L><L><D><V><D><T><A><A><G><G><F><Q><Q><R><Q><G><L><K><Y><C><L><P><L><T><F><C><I><H><T><G><L><S><Q><Y><I><A><V><E><A><A><E><G><R><N><K><N><E><V><F><Y><Q><C><P><D><Q><M><A><R><N><P><A><A><I><D><M><F><I><I><G><A><T><F><T><D><W><F><T><S><Y><V><K><N><V><V><S><G><G><F><P><I><I><R><D><Q><I><F><R><Y><V><H><D><P><E><C><V><A><T><T><G><D><I><T><V><S><V><S><T><S><F><L><P><E><L><S><S><V><H><P><P><H><Y><F><F><T><Y><R><I><R><I><E><M><S><K><D><A><L><P><E><K><A><C><Q><L><D><S><R><Y><W><R><I><T><N><A><K><G><D><V><E><E><V><Q><G><P><G><V><V><G><E><F><P><I><I><S><P><G><R><V><Y><E><Y><T><S><C><T><T><F><S><T><T><S><G><Y><M><E><G><Y><Y><T><F><H><F><L><Y><F><K><D><K><I><F><N><V><A><I><P><R><F><H><M><A><C><P><T><F><R><V><S><I><A><R><L><E><M><G><P><D><E><Y><E><E><M><E><E><E><E><E><E><E><E><E><E><D><E><D><D><D><S><A><D><M><D><E><S><D><E><D><D><E><E><E><R><R><R><R><V><F><D><V><P><I><R><R><R><R><C><S><R><L><F>
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.<BOP>
Q9UK99
Q14314
FGL2_HUMAN
pT49
Homo
<M><K><L><A><N><W><Y><W><L><S><S><A><V><L><A><T><Y><G><F><L><V><V><A><N><N><E><T><E><E><I><K><D><E><R><A><K><D><V><C><P><V><R><L><E><S><R><G><K><C><E><E><A><G><E><C><P><Y><Q><V><S><L><P><P><L><T><I><Q><L><P><K><Q><F><S><R><I><E><E><V><F><K><E><V><Q><N><L><K><E><I><V><N><S><L><K><K><S><C><Q><D><C><K><L><Q><A><D><D><N><G><D><P><G><R><N><G><L><L><L><P><S><T><G><A><P><G><E><V><G><D><N><R><V><R><E><L><E><S><E><V><N><K><L><S><S><E><L><K><N><A><K><E><E><I><N><V><L><H><G><R><L><E><K><L><N><L><V><N><M><N><N><I><E><N><Y><V><D><S><K><V><A><N><L><T><F><V><V><N><S><L><D><G><K><C><S><K><C><P><S><Q><E><Q><I><Q><S><R><P><V><Q><H><L><I><Y><K><D><C><S><D><Y><Y><A><I><G><K><R><S><S><E><T><Y><R><V><T><P><D><P><K><N><S><S><F><E><V><Y><C><D><M><E><T><M><G><G><G><W><T><V><L><Q><A><R><L><D><G><S><T><N><F><T><R><T><W><Q><D><Y><K><A><G><F><G><N><L><R><R><E><F><W><L><G><N><D><K><I><H><L><L><T><K><S><K><E><M><I><L><R><I><D><L><E><D><F><N><G><V><E><L><Y><A><L><Y><D><Q><F><Y><V><A><N><E><F><L><K><Y><R><L><H><V><G><N><Y><N><G><T><A><G><D><A><L><R><F><N><K><H><Y><N><H><D><L><K><F><F><T><T><P><D><K><D><N><D><R><Y><P><S><G><N><C><G><L><Y><Y><S><S><G><W><W><F><D><A><C><L><S><A><N><L><N><G><K><Y><Y><H><Q><K><Y><R><G><V><R><N><G><I><F><W><G><T><W><P><G><V><S><E><A><H><P><G><G><Y><K><S><S><F><K><E><A><K><M><M><I><R><P><K><H><F><K><P>
May play a role in physiologic lymphocyte functions at mucosal sites.<BOP>
Q14314
Q02363
ID2_HUMAN
Inhibitor of differentiation 2
Homo
<M><K><A><F><S><P><V><R><S><V><R><K><N><S><L><S><D><H><S><L><G><I><S><R><S><K><T><P><V><D><D><P><M><S><L><L><Y><N><M><N><D><C><Y><S><K><L><K><E><L><V><P><S><I><P><Q><N><K><K><V><S><K><M><E><I><L><Q><H><V><I><D><Y><I><L><D><L><Q><I><A><L><D><S><H><P><T><I><V><S><L><H><H><Q><R><P><G><Q><N><Q><A><S><R><T><P><L><T><T><L><N><T><D><I><S><I><L><S><L><Q><A><S><E><F><P><S><E><L><M><S><N><D><S><K><A><L><C><G>
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.<BOP>
Q02363
Q9UKL0
RCOR1_HUMAN
Protein CoREST
Homo
<M><P><A><M><V><E><K><G><P><E><V><S><G><K><R><R><G><R><N><N><A><A><A><S><A><S><A><A><A><A><S><A><A><A><S><A><A><C><A><S><P><A><A><T><A><A><S><G><A><A><A><S><S><A><S><A><A><A><A><S><A><A><A><A><P><N><N><G><Q><N><K><S><L><A><A><A><A><P><N><G><N><S><S><S><N><S><W><E><E><G><S><S><G><S><S><S><D><E><E><H><G><G><G><G><M><R><V><G><P><Q><Y><Q><A><V><V><P><D><F><D><P><A><K><L><A><R><R><S><Q><E><R><D><N><L><G><M><L><V><W><S><P><N><Q><N><L><S><E><A><K><L><D><E><Y><I><A><I><A><K><E><K><H><G><Y><N><M><E><Q><A><L><G><M><L><F><W><H><K><H><N><I><E><K><S><L><A><D><L><P><N><F><T><P><F><P><D><E><W><T><V><E><D><K><V><L><F><E><Q><A><F><S><F><H><G><K><T><F><H><R><I><Q><Q><M><L><P><D><K><S><I><A><S><L><V><K><F><Y><Y><S><W><K><K><T><R><T><K><T><S><V><M><D><R><H><A><R><K><Q><K><R><E><R><E><E><S><E><D><E><L><E><E><A><N><G><N><N><P><I><D><I><E><V><D><Q><N><K><E><S><K><K><E><V><P><P><T><E><T><V><P><Q><V><K><K><E><K><H><S><T><Q><A><K><N><R><A><K><R><K><P><P><K><G><M><F><L><S><Q><E><D><V><E><A><V><S><A><N><A><T><A><A><T><T><V><L><R><Q><L><D><M><E><L><V><S><V><K><R><Q><I><Q><N><I><K><Q><T><N><S><A><L><K><E><K><L><D><G><G><I><E><P><Y><R><L><P><E><V><I><Q><K><C><N><A><R><W><T><T><E><E><Q><L><L><A><V><Q><A><I><R><K><Y><G><R><D><F><Q><A><I><S><D><V><I><G><N><K><S><V><V><Q><V><K><N><F><F><V><N><Y><R><R><R><F><N><I><D><E><V><L><Q><E><W><E><A><E><H><G><K><E><E><T><N><G><P><S><N><Q><K><P><V><K><S><P><D><N><S><I><K><M><P><E><E><E><D><E><A><P><V><L><D><V><R><Y><A><S><A><S>
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<BOP>
Q9UKL0
Q969X6
UTP4_HUMAN
UTP4 small subunit processome component
Homo
<M><G><E><F><K><V><H><R><V><R><F><F><N><Y><V><P><S><G><I><R><C><V><A><Y><N><N><Q><S><N><R><L><A><V><S><R><T><D><G><T><V><E><I><Y><N><L><S><A><N><Y><F><Q><E><K><F><F><P><G><H><E><S><R><A><T><E><A><L><C><W><A><E><G><Q><R><L><F><S><A><G><L><N><G><E><I><M><E><Y><D><L><Q><A><L><N><I><K><Y><A><M><D><A><F><G><G><P><I><W><S><M><A><A><S><P><S><G><S><Q><L><L><V><G><C><E><D><G><S><V><K><L><F><Q><I><T><P><D><K><I><Q><F><E><R><N><F><D><R><Q><K><S><R><I><L><S><L><S><W><H><P><S><G><T><H><I><A><A><G><S><I><D><Y><I><S><V><F><D><V><K><S><G><S><A><V><H><K><M><I><V><D><R><Q><Y><M><G><V><S><K><R><K><C><I><V><W><G><V><A><F><L><S><D><G><T><I><I><S><V><D><S><A><G><K><V><Q><F><W><D><S><A><T><G><T><L><V><K><S><H><L><I><A><N><A><D><V><Q><S><I><A><V><A><D><Q><E><D><S><F><V><V><G><T><A><E><G><T><V><F><H><F><Q><L><V><P><V><T><S><N><S><S><E><K><Q><W><V><R><T><K><P><F><Q><H><H><T><H><D><V><R><T><V><A><H><S><P><T><A><L><I><S><G><G><T><D><T><H><L><V><F><R><P><L><M><E><K><V><E><V><K><N><Y><D><A><A><L><R><K><I><T><F><P><H><R><C><L><I><S><C><S><K><K><R><Q><L><L><L><F><Q><F><A><H><H><L><E><L><W><R><L><G><S><T><V><A><T><G><K><N><G><D><T><L><P><L><S><K><N><A><D><H><L><L><H><L><K><T><K><G><P><E><N><I><I><C><S><C><I><S><P><C><G><S><W><I><A><Y><S><T><V><S><R><F><F><L><Y><R><L><N><Y><E><H><D><N><I><S><L><K><R><V><S><K><M><P><A><F><L><R><S><A><L><Q><I><L><F><S><E><D><S><T><K><L><F><V><A><S><N><Q><G><A><L><H><I><V><Q><L><S><G><G><S><F><K><H><L><H><A><F><Q><P><Q><S><G><T><V><E><A><M><C><L><L><A><V><S><P><D><G><N><W><L><A><A><S><G><T><S><A><G><V><H><V><Y><N><V><K><Q><L><K><L><H><C><T><V><P><A><Y><N><F><P><V><T><A><M><A><I><A><P><N><T><N><N><L><V><I><A><H><S><D><Q><Q><V><F><E><Y><S><I><P><D><K><Q><Y><T><D><W><S><R><T><V><Q><K><Q><G><F><H><H><L><W><L><Q><R><D><T><P><I><T><H><I><S><F><H><P><K><R><P><M><H><I><L><L><H><D><A><Y><M><F><C><I><I><D><K><S><L><P><L><P><N><D><K><T><L><L><Y><N><P><F><P><P><T><N><E><S><D><V><I><R><R><R><T><A><H><A><F><K><I><S><K><I><Y><K><P><L><L><F><M><D><L><L><D><E><R><T><L><V><A><V><E><R><P><L><D><D><I><I><A><Q><L><P><P><P><I><K><K><K><K><F><G><T>
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase . May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV .<BOP>
Q969X6
Q9Y3A3
PHOCN_HUMAN
Preimplantation protein 3
Homo
<M><V><M><A><E><G><T><A><V><L><R><R><N><R><P><G><T><K><A><Q><D><F><Y><N><W><P><D><E><S><F><D><E><M><D><S><T><L><A><V><Q><Q><Y><I><Q><Q><N><I><R><A><D><C><S><N><I><D><K><I><L><E><P><P><E><G><Q><D><E><G><V><W><K><Y><E><H><L><R><Q><F><C><L><E><L><N><G><L><A><V><K><L><Q><S><E><C><H><P><D><T><C><T><Q><M><T><A><T><E><Q><W><I><F><L><C><A><A><H><K><T><P><K><E><C><P><A><I><D><Y><T><R><H><T><L><D><G><A><A><C><L><L><N><S><N><K><Y><F><P><S><R><V><S><I><K><E><S><S><V><A><K><L><G><S><V><C><R><R><I><Y><R><I><F><S><H><A><Y><F><H><H><R><Q><I><F><D><E><Y><E><N><E><T><F><L><C><H><R><F><T><K><F><V><M><K><Y><N><L><M><S><K><D><N><L><I><V><P><I><L><E><E><E><V><Q><N><S><V><S><G><E><S><E><A>
May play a role in membrane trafficking, specifically in membrane budding reactions.<BOP>
Q9Y3A3
Q3B820
F161A_HUMAN
Protein FAM161A
Homo
<M><A><T><S><H><R><V><A><K><L><V><A><S><S><L><Q><T><P><V><N><P><I><T><G><A><R><V><A><Q><Y><E><R><E><D><P><L><K><A><L><A><A><A><E><A><I><L><E><D><E><E><E><E><K><V><A><Q><P><A><G><A><S><A><D><L><N><T><S><F><S><G><V><D><E><H><A><P><I><S><Y><E><D><F><V><N><F><P><D><I><H><H><S><N><E><E><Y><F><K><K><V><E><E><L><K><A><A><H><I><E><T><M><A><K><L><E><K><M><Y><Q><D><K><L><H><L><K><E><V><Q><P><V><V><I><R><E><D><S><L><S><D><S><S><R><S><V><S><E><K><N><S><Y><H><P><V><S><L><M><T><S><F><S><E><P><D><L><G><Q><S><S><S><L><Y><V><S><S><S><E><E><E><L><P><N><L><E><K><E><Y><P><R><K><N><R><M><M><T><Y><A><K><E><L><I><N><N><M><W><T><D><F><C><V><E><D><Y><I><R><C><K><D><T><G><F><H><A><A><E><K><R><R><K><K><R><K><E><W><V><P><T><I><T><V><P><E><P><F><Q><M><M><I><R><E><Q><K><K><K><E><E><S><M><K><S><K><S><D><I><E><M><V><H><K><A><L><K><K><Q><E><E><D><P><E><Y><K><K><K><F><R><A><N><P><V><P><A><S><V><F><L><P><L><Y><H><D><L><V><K><Q><K><E><E><R><R><R><S><L><K><E><K><S><K><E><A><L><L><A><S><Q><K><P><F><K><F><I><A><R><E><E><Q><K><R><A><A><R><E><K><Q><L><R><D><F><L><K><Y><K><K><K><T><N><R><F><K><A><R><P><I><P><R><S><T><Y><G><S><T><T><N><D><K><L><K><E><E><E><L><Y><R><N><L><R><T><Q><L><R><A><Q><E><H><L><Q><N><S><S><P><L><P><C><R><S><A><C><G><C><R><N><P><R><C><P><E><Q><A><V><K><L><K><C><K><H><K><V><R><C><P><T><P><D><F><E><D><L><P><E><R><Y><Q><K><H><L><S><E><H><K><S><P><K><L><L><T><V><C><K><P><F><D><L><H><A><S><P><H><A><S><I><K><R><E><K><I><L><A><D><I><E><A><D><E><E><N><L><K><E><T><R><W><P><Y><L><S><P><R><R><K><S><P><V><R><C><A><G><V><N><P><V><P><C><N><C><N><P><P><V><P><T><V><S><S><R><G><R><E><Q><A><V><R><K><S><E><K><E><R><M><R><E><Y><Q><R><E><L><E><E><R><E><E><K><L><K><K><R><P><L><L><F><E><R><V><A><Q><K><N><A><R><M><A><A><E><K><H><Y><S><N><T><L><K><A><L><G><I><S><D><E><F><V><S><K><K><G><Q><S><G><K><V><L><E><Y><F><N><N><Q><E><T><K><S><V><T><E><D><K><E><S><F><N><E><E><E><K><I><E><E><R><E><N><G><E><E><N><Y><F><I><D><T><N><S><Q><D><S><Y><K><E><K><D><E><A><N><E><E><S><E><E><E><K><S><V><E><E><S><H>
Involved in ciliogenesis.<BOP>
Q3B820
Q92988
DLX4_HUMAN
Homeobox protein DLX-8
Homo
<M><T><S><L><P><C><P><L><P><G><R><D><A><S><K><A><V><F><P><D><L><A><P><V><P><S><V><A><A><A><Y><P><L><G><L><S><P><T><T><A><A><S><P><N><L><S><Y><S><R><P><Y><G><H><L><L><S><Y><P><Y><T><E><P><A><N><P><G><D><S><Y><L><S><C><Q><Q><P><A><A><L><S><Q><P><L><C><G><P><A><E><H><P><Q><E><L><E><A><D><S><E><K><P><R><L><S><P><E><P><S><E><R><R><P><Q><A><P><A><K><K><L><R><K><P><R><T><I><Y><S><S><L><Q><L><Q><H><L><N><Q><R><F><Q><H><T><Q><Y><L><A><L><P><E><R><A><Q><L><A><A><Q><L><G><L><T><Q><T><Q><V><K><I><W><F><Q><N><K><R><S><K><Y><K><K><L><L><K><Q><N><S><G><G><Q><E><G><D><F><P><G><R><T><F><S><V><S><P><C><S><P><P><L><P><S><L><W><D><L><P><K><A><G><T><L><P><T><S><G><Y><G><N><S><F><G><A><W><Y><Q><H><H><S><S><D><V><L><A><S><P><Q><M><M>
May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.<BOP>
Q92988
Q15758
AAAT_HUMAN
Solute carrier family 1 member 5
Homo
<M><V><A><D><P><P><R><D><S><K><G><L><A><A><A><E><P><T><A><N><G><G><L><A><L><A><S><I><E><D><Q><G><A><A><A><G><G><Y><C><G><S><R><D><Q><V><R><R><C><L><R><A><N><L><L><V><L><L><T><V><V><A><V><V><A><G><V><A><L><G><L><G><V><S><G><A><G><G><A><L><A><L><G><P><E><R><L><S><A><F><V><F><P><G><E><L><L><L><R><L><L><R><M><I><I><L><P><L><V><V><C><S><L><I><G><G><A><A><S><L><D><P><G><A><L><G><R><L><G><A><W><A><L><L><F><F><L><V><T><T><L><L><A><S><A><L><G><V><G><L><A><L><A><L><Q><P><G><A><A><S><A><A><I><N><A><S><V><G><A><A><G><S><A><E><N><A><P><S><K><E><V><L><D><S><F><L><D><L><A><R><N><I><F><P><S><N><L><V><S><A><A><F><R><S><Y><S><T><T><Y><E><E><R><N><I><T><G><T><R><V><K><V><P><V><G><Q><E><V><E><G><M><N><I><L><G><L><V><V><F><A><I><V><F><G><V><A><L><R><K><L><G><P><E><G><E><L><L><I><R><F><F><N><S><F><N><E><A><T><M><V><L><V><S><W><I><M><W><Y><A><P><V><G><I><M><F><L><V><A><G><K><I><V><E><M><E><D><V><G><L><L><F><A><R><L><G><K><Y><I><L><C><C><L><L><G><H><A><I><H><G><L><L><V><L><P><L><I><Y><F><L><F><T><R><K><N><P><Y><R><F><L><W><G><I><V><T><P><L><A><T><A><F><G><T><S><S><S><S><A><T><L><P><L><M><M><K><C><V><E><E><N><N><G><V><A><K><H><I><S><R><F><I><L><P><I><G><A><T><V><N><M><D><G><A><A><L><F><Q><C><V><A><A><V><F><I><A><Q><L><S><Q><Q><S><L><D><F><V><K><I><I><T><I><L><V><T><A><T><A><S><S><V><G><A><A><G><I><P><A><G><G><V><L><T><L><A><I><I><L><E><A><V><N><L><P><V><D><H><I><S><L><I><L><A><V><D><W><L><V><D><R><S><C><T><V><L><N><V><E><G><D><A><L><G><A><G><L><L><Q><N><Y><V><D><R><T><E><S><R><S><T><E><P><E><L><I><Q><V><K><S><E><L><P><L><D><P><L><P><V><P><T><E><E><G><N><P><L><L><K><H><Y><R><G><P><A><G><D><A><T><V><A><S><E><K><E><S><V><M>
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<BOP>
Q15758
Q9UC07
ZNF69_HUMAN
hZNF3
Homo
<M><P><C><C><S><H><R><R><C><R><E><D><P><G><T><S><E><S><Q><E><M><D><P><V><A><F><D><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><D><I><S><Q><R><K><L><Y><K><E><V><M><L><E><T><F><R><N><L><T><S><V><G><K><S><W><K><D><Q><N><I><E><Y><E><Y><Q><N><P><R><R><N><F><R><S><L><I><E><K><K><V><N><E><I><K><D><D><S><H><C><G><E><T><F><T><Q><V><P><D><D><R><L><N><F><Q><E><K><K><A><S><P><E><I><K><S><C><D><S><F><V><C><G><E><V><G><L><G><N><S><S><F><N><M><N><I><R><G><D><I><G><H><K><A><Y><E><Y><Q><E><Y><G><P><K><P><C><K><C><Q><Q><P><K><K><A><F><R><Y><H><P><S><F><R><T><P><Q><R><D><H><T><G><E><K><P><Y><A><C><K><E><C><G><K><T><F><I><S><H><S><S><I><Q><R><H><V><V><M><H><S><G><D><G><P><Y><K><C><K><F><C><G><K><A><F><H><C><L><S><L><Y><L><I><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><S><F><S><Y><S><A><T><L><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><Q><Q><C><G><K><A><F><H><S><P><R><C><Y><R><R><H><E><R><I><H><T><G><E><K><A><Y><Q><C><K><E><C><G><K><A><F><T><C><P><Q><Y><V><R><I><H><E><R><T><H><S><R><K><K><P><Y><E><C><T><Q><C><G><K><A><L><S><S><L><T><S><F><Q><T><H><I><R><M><H><S><G><E><R><P><Y><E><C><K><I><C><G><K><G><F><C><S><A><N><S><F><Q><R><H><E><K><T><H><S><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><I><H><S><S><S><L><R><Y><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><S><S><H><L><Q><L><H><G><R><T><H><T><G><E><K><P><Y><E><C><Q><E><C><G><K><A><F><R><S><M><K><N><L><Q><S><H><E><R><T><Q><T><H><V><R><I><H><S><G><E><R><P><Y><K><C><K><L><C><G><K><G><F><Y><C><P><K><S><L><Q><R><H><E><K><T><H><T><G><E><K><L><Y><E><C><K><Q><C><G><E><A><F><S><S><S><S><S><F><R><Y><H><E><R><T><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><R><A><A><S><V><L><R><M><H><G><R><T><H><P><E><D><K><P><Y><E><C><K><Q>
May be involved in transcriptional regulation.<BOP>
Q9UC07
Q8NH04
O2T27_HUMAN
Olfactory receptor OR1-67
Homo
<M><E><Q><S><N><Y><S><V><Y><A><D><F><I><L><L><G><L><F><S><N><A><R><F><P><W><L><L><F><A><L><I><L><L><V><F><L><T><S><I><A><S><N><V><V><K><I><I><L><I><H><I><D><S><R><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><R><D><I><L><Y><I><S><T><I><V><P><K><M><L><V><D><Q><V><M><S><Q><R><A><I><S><F><A><G><C><T><A><Q><H><F><L><Y><L><T><L><A><G><A><E><F><F><L><L><G><L><M><S><Y><D><R><Y><V><A><I><C><N><P><L><H><Y><P><V><L><M><S><R><K><I><C><W><L><I><V><A><A><A><W><L><G><G><S><I><D><G><F><L><L><T><P><V><T><M><Q><F><P><F><C><A><S><R><E><I><N><H><F><F><C><E><V><P><A><L><L><K><L><S><C><T><D><T><S><A><Y><E><T><A><M><Y><V><C><C><I><M><M><L><L><I><P><F><S><V><I><S><G><S><Y><T><R><I><L><I><T><V><Y><R><M><S><E><A><E><G><R><G><K><A><V><A><T><C><S><S><H><M><V><V><V><S><L><F><Y><G><A><A><M><Y><T><Y><V><L><P><H><S><Y><H><T><P><E><Q><D><K><A><V><S><A><F><Y><T><I><L><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><T><G><A><L><Q><K><V><V><G><R><C><V><S><S><G><K><V><T><T><F>
Odorant receptor.<BOP>
Q8NH04
Q9Y3D0
CIA2B_HUMAN
Protein FAM96B
Homo
<M><V><G><G><G><G><V><G><G><G><L><L><E><N><A><N><P><L><I><Y><Q><R><S><G><E><R><P><V><T><A><G><E><E><D><E><Q><V><P><D><S><I><D><A><R><E><I><F><D><L><I><R><S><I><N><D><P><E><H><P><L><T><L><E><E><L><N><V><V><E><Q><V><R><V><Q><V><S><D><P><E><S><T><V><A><V><A><F><T><P><T><I><P><H><C><S><M><A><T><L><I><G><L><S><I><K><V><K><L><L><R><S><L><P><Q><R><F><K><M><D><V><H><I><T><P><G><T><H><A><S><E><H><A><V><N><K><Q><L><A><D><K><E><R><V><A><A><A><L><E><N><T><H><L><L><E><V><V><N><Q><C><L><S><A><R><S>
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins . As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD . Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis .<BOP>
Q9Y3D0
P11021
BIP_HUMAN
Immunoglobulin heavy chain-binding protein
Homo
<M><K><L><S><L><V><A><A><M><L><L><L><L><S><A><A><R><A><E><E><E><D><K><K><E><D><V><G><T><V><V><G><I><D><L><G><T><T><Y><S><C><V><G><V><F><K><N><G><R><V><E><I><I><A><N><D><Q><G><N><R><I><T><P><S><Y><V><A><F><T><P><E><G><E><R><L><I><G><D><A><A><K><N><Q><L><T><S><N><P><E><N><T><V><F><D><A><K><R><L><I><G><R><T><W><N><D><P><S><V><Q><Q><D><I><K><F><L><P><F><K><V><V><E><K><K><T><K><P><Y><I><Q><V><D><I><G><G><G><Q><T><K><T><F><A><P><E><E><I><S><A><M><V><L><T><K><M><K><E><T><A><E><A><Y><L><G><K><K><V><T><H><A><V><V><T><V><P><A><Y><F><N><D><A><Q><R><Q><A><T><K><D><A><G><T><I><A><G><L><N><V><M><R><I><I><N><E><P><T><A><A><A><I><A><Y><G><L><D><K><R><E><G><E><K><N><I><L><V><F><D><L><G><G><G><T><F><D><V><S><L><L><T><I><D><N><G><V><F><E><V><V><A><T><N><G><D><T><H><L><G><G><E><D><F><D><Q><R><V><M><E><H><F><I><K><L><Y><K><K><K><T><G><K><D><V><R><K><D><N><R><A><V><Q><K><L><R><R><E><V><E><K><A><K><R><A><L><S><S><Q><H><Q><A><R><I><E><I><E><S><F><Y><E><G><E><D><F><S><E><T><L><T><R><A><K><F><E><E><L><N><M><D><L><F><R><S><T><M><K><P><V><Q><K><V><L><E><D><S><D><L><K><K><S><D><I><D><E><I><V><L><V><G><G><S><T><R><I><P><K><I><Q><Q><L><V><K><E><F><F><N><G><K><E><P><S><R><G><I><N><P><D><E><A><V><A><Y><G><A><A><V><Q><A><G><V><L><S><G><D><Q><D><T><G><D><L><V><L><L><D><V><C><P><L><T><L><G><I><E><T><V><G><G><V><M><T><K><L><I><P><R><N><T><V><V><P><T><K><K><S><Q><I><F><S><T><A><S><D><N><Q><P><T><V><T><I><K><V><Y><E><G><E><R><P><L><T><K><D><N><H><L><L><G><T><F><D><L><T><G><I><P><P><A><P><R><G><V><P><Q><I><E><V><T><F><E><I><D><V><N><G><I><L><R><V><T><A><E><D><K><G><T><G><N><K><N><K><I><T><I><T><N><D><Q><N><R><L><T><P><E><E><I><E><R><M><V><N><D><A><E><K><F><A><E><E><D><K><K><L><K><E><R><I><D><T><R><N><E><L><E><S><Y><A><Y><S><L><K><N><Q><I><G><D><K><E><K><L><G><G><K><L><S><S><E><D><K><E><T><M><E><K><A><V><E><E><K><I><E><W><L><E><S><H><Q><D><A><D><I><E><D><F><K><A><K><K><K><E><L><E><E><I><V><Q><P><I><I><S><K><L><Y><G><S><A><G><P><P><P><T><G><E><E><D><T><A><E><K><D><E><L>
(Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi . Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression .<BOP>
P11021
P04066
FUCO_HUMAN
Alpha-L-fucoside fucohydrolase 1
Homo
<M><R><A><P><G><M><R><S><R><P><A><G><P><A><L><L><L><L><L><L><F><L><G><A><A><E><S><V><R><R><A><Q><P><P><R><R><Y><T><P><D><W><P><S><L><D><S><R><P><L><P><A><W><F><D><E><A><K><F><G><V><F><I><H><W><G><V><F><S><V><P><A><W><G><S><E><W><F><W><W><H><W><Q><G><E><G><R><P><Q><Y><Q><R><F><M><R><D><N><Y><P><P><G><F><S><Y><A><D><F><G><P><Q><F><T><A><R><F><F><H><P><E><E><W><A><D><L><F><Q><A><A><G><A><K><Y><V><V><L><T><T><K><H><H><E><G><F><T><N><W><P><S><P><V><S><W><N><W><N><S><K><D><V><G><P><H><R><D><L><V><G><E><L><G><T><A><L><R><K><R><N><I><R><Y><G><L><Y><H><S><L><L><E><W><F><H><P><L><Y><L><L><D><K><K><N><G><F><K><T><Q><H><F><V><S><A><K><T><M><P><E><L><Y><D><L><V><N><S><Y><K><P><D><L><I><W><S><D><G><E><W><E><C><P><D><T><Y><W><N><S><T><N><F><L><S><W><L><Y><N><D><S><P><V><K><D><E><V><V><V><N><D><R><W><G><Q><N><C><S><C><H><H><G><G><Y><Y><N><C><E><D><K><F><K><P><Q><S><L><P><D><H><K><W><E><M><C><T><S><I><D><K><F><S><W><G><Y><R><R><D><M><A><L><S><D><V><T><E><E><S><E><I><I><S><E><L><V><Q><T><V><S><L><G><G><N><Y><L><L><N><I><G><P><T><K><D><G><L><I><V><P><I><F><Q><E><R><L><L><A><V><G><K><W><L><S><I><N><G><E><A><I><Y><A><S><K><P><W><R><V><Q><W><E><K><N><T><T><S><V><W><Y><T><S><K><G><S><A><V><Y><A><I><F><L><H><W><P><E><N><G><V><L><N><L><E><S><P><I><T><T><S><T><T><K><I><T><M><L><G><I><Q><G><D><L><K><W><S><T><D><P><D><K><G><L><F><I><S><L><P><Q><L><P><P><S><A><V><P><A><E><F><A><W><T><I><K><L><T><G><V><K>
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.<BOP>
P04066
B2RXH4
BTBDI_HUMAN
BTB/POZ domain-containing protein 18
Homo
<M><C><S><P><A><S><P><K><I><L><Y><R><N><P><R><F><L><R><L><A><F><L><Q><L><H><H><Q><Q><Q><S><D><V><F><C><D><V><L><L><Q><A><E><G><E><A><V><P><A><H><C><C><I><L><S><A><C><S><P><F><F><T><E><R><L><E><R><E><R><P><A><Q><G><G><K><V><V><L><E><L><G><G><L><K><I><S><T><L><R><K><L><V><D><F><L><Y><T><S><E><M><E><V><S><Q><E><E><A><Q><D><V><L><S><A><A><R><Q><L><R><V><S><E><L><E><S><L><Q><L><E><G><G><K><L><V><K><A><P><Q><G><R><R><L><N><R><E><C><L><Q><P><T><S><A><A><P><I><S><A><R><V><V><T><P><S><H><H><P><H><T><P><L><P><T><N><Q><T><P><C><P><L><G><A><I><R><L><K><S><L><G><K><E><E><G><P><Q><E><N><N><R><Q><N><A><D><N><L><S><G><T><L><L><L><K><R><K><A><R><A><C><P><T><P><Q><E><K><N><S><S><P><S><S><H><S><Q><E><P><R><E><N><K><N><D><T><A><L><D><P><T><V><L><S><P><P><S><L><Y><P><S><V><D><K><H><L><L><P><R><K><I><R><L><S><R><S><K><P><S><P><G><I><C><T><S><K><P><S><S><I><L><S><G><S><S><S><V><P><A><T><P><G><R><R><L><W><R><Q><R><S><V><N><K><E><T><P><E><D><K><P><K><P><G><R><A><S><P><L><Q><S><T><P><N><P><S><G><L><G><K><T><G><G><S><R><K><R><S><P><E><V><R><A><P><N><S><D><S><A><E><E><G><Q><V><G><R><V><K><L><R><K><I><V><N><G><T><C><W><E><V><V><Q><E><T><P><L><K><N><T><Q><D><S><P><Q><I><P><D><P><G><G><D><F><Q><E><P><S><G><T><Q><P><F><S><S><N><E><Q><E><M><S><P><T><R><T><E><L><C><Q><D><S><P><M><C><T><K><L><Q><D><I><L><V><S><A><S><H><S><P><D><H><P><V><V><K><S><E><F><E><S><S><P><E><L><V><E><K><E><P><M><L><A><I><D><C><R><E><P><Y><A><F><D><T><A><L><L><E><Q><P><C><E><A><E><E><Y><R><I><T><S><A><A><A><T><S><E><L><E><E><I><L><D><F><M><L><C><G><S><D><I><E><P><P><I><G><S><L><E><S><P><G><A><E><G><C><R><T><P><T><Y><H><L><T><E><T><G><K><N><W><I><E><G><E><E><W><C><L><P><D><M><E><L><W><P><R><E><L><T><E><L><E><K><E><P><A><G><E><N><R><G><P><T><E><L><L><S><P><L><V><M><P><S><E><V><S><E><V><L><S><V><G><G><R><W><T><P><D><L><E><I><T><S><S><Q><P><L><D><G><Q><E><D><K><L><L><H><V><S><S><L><D><T><P><Q><R><S><Y><G><D><L><S><P><P><C><S><N><W><V><E><T><G><L><E><V><S><L><T><T><D><E><L><L><Y><P><S><P><K><A><G><K><E><V><S><G><H><S><E><L><L><G><S><L><P><A><S><S><E><E><E><E><I><D><V><V><D><W><T><A><E><G><R><L><V><P><T><T><V><P><S><V><W><P><D><P><S><S><E><S><E><T><E><V><D><I><L><T>
Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.<BOP>
B2RXH4
Q8IUB9
KR191_HUMAN
High tyrosine-glycine keratin-associated protein 19.1
Homo
<M><S><H><Y><G><S><Y><Y><G><G><L><G><Y><S><C><G><G><F><G><G><L><G><Y><G><Y><G><C><G><C><G><S><F><C><R><R><G><S><G><C><G><Y><G><G><Y><G><Y><G><S><G><F><G><S><Y><G><Y><G><S><G><F><G><G><Y><G><Y><G><S><G><F><G><G><Y><G><Y><G><C><C><R><P><S><Y><N><G><G><Y><G><F><S><G><F><Y>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q8IUB9
Q8NH59
O51Q1_HUMAN
Olfactory receptor 51Q1
Homo
<M><S><Q><V><T><N><T><T><Q><E><G><I><Y><F><I><L><T><D><I><P><G><F><E><A><S><H><I><W><I><S><I><P><V><C><C><L><Y><T><I><S><I><M><G><N><T><T><I><L><T><V><I><R><T><E><P><S><V><H><Q><R><M><Y><L><F><L><S><M><L><A><L><T><D><L><G><L><T><L><T><T><L><P><T><V><M><Q><L><L><W><F><N><V><R><R><I><S><S><E><A><C><F><A><Q><F><F><F><L><H><G><F><S><F><M><E><S><S><V><L><L><A><M><S><V><D><C><Y><V><A><I><C><C><P><L><H><Y><A><S><I><L><T><N><E><V><I><G><R><T><G><L><A><I><I><C><C><C><V><L><A><V><L><P><S><L><F><L><L><K><R><L><P><F><C><H><S><H><L><L><S><R><S><Y><C><L><H><Q><D><M><I><R><L><V><C><A><D><I><R><L><N><S><W><Y><G><F><A><L><A><L><L><I><I><I><V><D><P><L><L><I><V><I><S><Y><T><L><I><L><K><N><I><L><G><T><A><T><W><A><E><R><L><R><A><L><N><N><C><L><S><H><I><L><A><V><L><V><L><Y><I><P><M><V><G><V><S><M><T><H><R><F><A><K><H><A><S><P><L><V><H><V><I><M><A><N><I><Y><L><L><A><P><P><V><M><N><P><I><I><Y><S><V><K><N><K><Q><I><Q><W><G><M><L><N><F><L><S><L><K><N><M><H><S><R>
Odorant receptor.<BOP>
Q8NH59
Q96EH8
NEUL3_HUMAN
RING-type E3 ubiquitin transferase NEURL3
Homo
<M><G><A><Q><L><C><F><E><A><N><A><K><A><P><R><E><A><L><R><F><H><A><E><A><K><G><A><Q><V><R><L><D><T><R><G><C><I><A><H><R><R><T><T><F><H><D><G><I><V><F><S><Q><R><P><V><R><L><G><E><R><V><A><L><R><V><L><R><E><E><S><G><W><C><G><G><L><R><V><G><F><T><R><L><D><P><A><C><V><S><V><P><S><L><P><P><F><L><C><P><D><L><E><E><Q><S><P><T><W><A><A><V><L><P><E><G><C><A><L><T><G><D><L><V><R><F><W><V><D><R><R><G><C><L><F><A><K><V><N><A><G><C><R><L><L><L><R><E><G><V><P><V><G><A><P><L><W><A><V><M><D><V><Y><G><T><T><K><A><I><E><L><L><D><P><T><A><S><R><L><P><T><P><M><P><W><D><L><S><N><K><A><V><P><E><P><K><A><T><P><G><E><E><C><A><I><C><F><Y><H><A><A><N><T><R><L><V><P><C><G><H><T><Y><F><C><R><Y><C><A><W><R><V><F><S><D><T><A><K><C><P><V><C><R><W><Q><I><E><A><V><A><P><A><Q><G><P><P><A><L><R><V><E><E><G><S>
E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity . Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 . Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 .<BOP>
Q96EH8
P19438
TNR1A_HUMAN
Tumor necrosis factor-binding protein 1
Homo
<M><G><L><S><T><V><P><D><L><L><L><P><L><V><L><L><E><L><L><V><G><I><Y><P><S><G><V><I><G><L><V><P><H><L><G><D><R><E><K><R><D><S><V><C><P><Q><G><K><Y><I><H><P><Q><N><N><S><I><C><C><T><K><C><H><K><G><T><Y><L><Y><N><D><C><P><G><P><G><Q><D><T><D><C><R><E><C><E><S><G><S><F><T><A><S><E><N><H><L><R><H><C><L><S><C><S><K><C><R><K><E><M><G><Q><V><E><I><S><S><C><T><V><D><R><D><T><V><C><G><C><R><K><N><Q><Y><R><H><Y><W><S><E><N><L><F><Q><C><F><N><C><S><L><C><L><N><G><T><V><H><L><S><C><Q><E><K><Q><N><T><V><C><T><C><H><A><G><F><F><L><R><E><N><E><C><V><S><C><S><N><C><K><K><S><L><E><C><T><K><L><C><L><P><Q><I><E><N><V><K><G><T><E><D><S><G><T><T><V><L><L><P><L><V><I><F><F><G><L><C><L><L><S><L><L><F><I><G><L><M><Y><R><Y><Q><R><W><K><S><K><L><Y><S><I><V><C><G><K><S><T><P><E><K><E><G><E><L><E><G><T><T><T><K><P><L><A><P><N><P><S><F><S><P><T><P><G><F><T><P><T><L><G><F><S><P><V><P><S><S><T><F><T><S><S><S><T><Y><T><P><G><D><C><P><N><F><A><A><P><R><R><E><V><A><P><P><Y><Q><G><A><D><P><I><L><A><T><A><L><A><S><D><P><I><P><N><P><L><Q><K><W><E><D><S><A><H><K><P><Q><S><L><D><T><D><D><P><A><T><L><Y><A><V><V><E><N><V><P><P><L><R><W><K><E><F><V><R><R><L><G><L><S><D><H><E><I><D><R><L><E><L><Q><N><G><R><C><L><R><E><A><Q><Y><S><M><L><A><T><W><R><R><R><T><P><R><R><E><A><T><L><E><L><L><G><R><V><L><R><D><M><D><L><L><G><C><L><E><D><I><E><E><A><L><C><G><P><A><A><L><P><P><A><P><S><L><L><R>
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.<BOP>
P19438
Q9HAJ7
SP30L_HUMAN
Sin3-associated protein p30-like
Homo
<M><N><G><F><S><T><E><E><D><S><R><E><G><P><P><A><A><P><A><A><A><A><P><G><Y><G><Q><S><C><C><L><I><E><D><G><E><R><C><V><R><P><A><G><N><A><S><F><S><K><R><V><Q><K><S><I><S><Q><K><K><L><K><L><D><I><D><K><S><V><R><H><L><Y><I><C><D><F><H><K><N><F><I><Q><S><V><R><N><K><R><K><R><K><T><S><D><D><G><G><D><S><P><E><H><D><T><D><I><P><E><V><D><L><F><Q><L><Q><V><N><T><L><R><R><Y><K><R><H><Y><K><L><Q><T><R><P><G><F><N><K><A><Q><L><A><E><T><V><S><R><H><F><R><N><I><P><V><N><E><K><E><T><L><A><Y><F><I><Y><M><V><K><S><N><K><S><R><L><D><Q><K><S><E><G><G><K><Q><L><E>
Functions as transcription repressor; its activity is marginally lower than that of isoform 1.<BOP>
Q9HAJ7
Q8NGL3
OR5DE_HUMAN
Olfactory receptor OR11-150
Homo
<M><M><M><V><L><R><N><L><S><M><E><P><T><F><A><L><L><G><F><T><D><Y><P><K><L><Q><I><P><L><F><L><V><F><L><L><M><Y><V><I><T><V><V><G><N><L><G><M><I><I><I><I><K><I><N><P><K><F><H><T><P><M><Y><F><F><L><S><H><L><S><F><V><D><F><C><Y><S><S><I><V><T><P><K><L><L><E><N><L><V><M><A><D><K><S><I><F><Y><F><S><C><M><M><Q><Y><F><L><S><C><T><A><V><V><T><E><S><F><L><L><A><V><M><A><Y><D><R><F><V><A><I><C><N><P><L><L><Y><T><V><A><M><S><Q><R><L><C><A><L><L><V><A><G><S><Y><L><W><G><M><F><G><P><L><V><L><L><C><Y><A><L><R><L><N><F><S><G><P><N><V><I><N><H><F><F><C><E><Y><T><A><L><I><S><V><S><G><S><D><I><L><I><P><H><L><L><L><F><S><F><A><T><F><N><E><M><C><T><L><L><I><I><L><T><S><Y><V><F><I><F><V><T><V><L><K><I><R><S><V><S><G><R><H><K><A><F><S><T><W><A><S><H><L><T><S><I><T><I><F><H><G><T><I><L><F><L><Y><C><V><P><N><S><K><N><S><R><Q><T><V><K><V><A><S><V><F><Y><T><V><V><N><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><D><A><F><W><K><L><I><H><T><Q><V><P><F><H>
Odorant receptor.<BOP>
Q8NGL3
O43174
CP26A_HUMAN
Retinoic acid-metabolizing cytochrome
Homo
<M><G><L><P><A><L><L><A><S><A><L><C><T><F><V><L><P><L><L><L><F><L><A><A><I><K><L><W><D><L><Y><C><V><S><G><R><D><R><S><C><A><L><P><L><P><P><G><T><M><G><F><P><F><F><G><E><T><L><Q><M><V><L><Q><R><R><K><F><L><Q><M><K><R><R><K><Y><G><F><I><Y><K><T><H><L><F><G><R><P><T><V><R><V><M><G><A><D><N><V><R><R><I><L><L><G><E><H><R><L><V><S><V><H><W><P><A><S><V><R><T><I><L><G><S><G><C><L><S><N><L><H><D><S><S><H><K><Q><R><K><K><V><I><M><R><A><F><S><R><E><A><L><E><C><Y><V><P><V><I><T><E><E><V><G><S><S><L><E><Q><W><L><S><C><G><E><R><G><L><L><V><Y><P><E><V><K><R><L><M><F><R><I><A><M><R><I><L><L><G><C><E><P><Q><L><A><G><D><G><D><S><E><Q><Q><L><V><E><A><F><E><E><M><T><R><N><L><F><S><L><P><I><D><V><P><F><S><G><L><Y><R><G><M><K><A><R><N><L><I><H><A><R><I><E><Q><N><I><R><A><K><I><C><G><L><R><A><S><E><A><G><Q><G><C><K><D><A><L><Q><L><L><I><E><H><S><W><E><R><G><E><R><L><D><M><Q><A><L><K><Q><S><S><T><E><L><L><F><G><G><H><E><T><T><A><S><A><A><T><S><L><I><T><Y><L><G><L><Y><P><H><V><L><Q><K><V><R><E><E><L><K><S><K><G><L><L><C><K><S><N><Q><D><N><K><L><D><M><E><I><L><E><Q><L><K><Y><I><G><C><V><I><K><E><T><L><R><L><N><P><P><V><P><G><G><F><R><V><A><L><K><T><F><E><L><N><G><Y><Q><I><P><K><G><W><N><V><I><Y><S><I><C><D><T><H><D><V><A><E><I><F><T><N><K><E><E><F><N><P><D><R><F><M><L><P><H><P><E><D><A><S><R><F><S><F><I><P><F><G><G><G><L><R><S><C><V><G><K><E><F><A><K><I><L><L><K><I><F><T><V><E><L><A><R><H><C><D><W><Q><L><L><N><G><P><P><T><M><K><T><S><P><T><V><Y><P><V><D><N><L><P><A><R><F><T><H><F><H><G><E><I>
A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers . May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid .<BOP>
O43174
P36871
PGM1_HUMAN
Glucose phosphomutase 1
Homo
<M><V><K><I><V><T><V><K><T><Q><A><Y><Q><D><Q><K><P><G><T><S><G><L><R><K><R><V><K><V><F><Q><S><S><A><N><Y><A><E><N><F><I><Q><S><I><I><S><T><V><E><P><A><Q><R><Q><E><A><T><L><V><V><G><G><D><G><R><F><Y><M><K><E><A><I><Q><L><I><A><R><I><A><A><A><N><G><I><G><R><L><V><I><G><Q><N><G><I><L><S><T><P><A><V><S><C><I><I><R><K><I><K><A><I><G><G><I><I><L><T><A><S><H><N><P><G><G><P><N><G><D><F><G><I><K><F><N><I><S><N><G><G><P><A><P><E><A><I><T><D><K><I><F><Q><I><S><K><T><I><E><E><Y><A><V><C><P><D><L><K><V><D><L><G><V><L><G><K><Q><Q><F><D><L><E><N><K><F><K><P><F><T><V><E><I><V><D><S><V><E><A><Y><A><T><M><L><R><S><I><F><D><F><S><A><L><K><E><L><L><S><G><P><N><R><L><K><I><R><I><D><A><M><H><G><V><V><G><P><Y><V><K><K><I><L><C><E><E><L><G><A><P><A><N><S><A><V><N><C><V><P><L><E><D><F><G><G><H><H><P><D><P><N><L><T><Y><A><A><D><L><V><E><T><M><K><S><G><E><H><D><F><G><A><A><F><D><G><D><G><D><R><N><M><I><L><G><K><H><G><F><F><V><N><P><S><D><S><V><A><V><I><A><A><N><I><F><S><I><P><Y><F><Q><Q><T><G><V><R><G><F><A><R><S><M><P><T><S><G><A><L><D><R><V><A><S><A><T><K><I><A><L><Y><E><T><P><T><G><W><K><F><F><G><N><L><M><D><A><S><K><L><S><L><C><G><E><E><S><F><G><T><G><S><D><H><I><R><E><K><D><G><L><W><A><V><L><A><W><L><S><I><L><A><T><R><K><Q><S><V><E><D><I><L><K><D><H><W><Q><K><Y><G><R><N><F><F><T><R><Y><D><Y><E><E><V><E><A><E><G><A><N><K><M><M><K><D><L><E><A><L><M><F><D><R><S><F><V><G><K><Q><F><S><A><N><D><K><V><Y><T><V><E><K><A><D><N><F><E><Y><S><D><P><V><D><G><S><I><S><R><N><Q><G><L><R><L><I><F><T><D><G><S><R><I><V><F><R><L><S><G><T><G><S><A><G><A><T><I><R><L><Y><I><D><S><Y><E><K><D><V><A><K><I><N><Q><D><P><Q><V><M><L><A><P><L><I><S><I><A><L><K><V><S><Q><L><Q><E><R><T><G><R><T><A><P><T><V><I><T>
This enzyme participates in both the breakdown and synthesis of glucose.<BOP>
P36871
Q8IYG6
LRC56_HUMAN
Leucine-rich repeat-containing protein 56
Homo
<M><D><L><G><W><D><R><S><R><G><P><R><R><S><T><S><S><V><R><V><R><E><L><S><W><Q><G><L><H><N><P><C><P><Q><S><K><G><P><G><S><Q><R><D><R><L><G><E><Q><L><V><E><E><Y><L><S><P><A><R><L><Q><A><L><A><R><V><D><D><L><R><L><V><R><T><L><E><M><C><V><D><T><R><E><G><S><L><G><N><F><G><V><H><L><P><N><L><D><Q><L><K><L><N><G><S><H><L><G><S><L><R><D><L><G><T><S><L><G><H><L><Q><V><L><W><L><A><R><C><G><L><A><D><L><D><G><I><A><S><L><P><A><L><K><E><L><Y><A><S><Y><N><N><I><S><D><L><S><P><L><C><L><L><E><Q><L><E><V><L><D><L><E><G><N><S><V><E><D><L><G><Q><V><R><Y><L><Q><L><C><P><R><L><A><M><L><T><L><E><G><N><L><V><C><L><Q><P><A><P><G><P><T><N><K><V><P><R><G><Y><N><Y><R><A><E><V><R><K><L><I><P><Q><L><Q><V><L><D><E><V><P><A><A><H><T><G><P><P><A><P><P><R><L><S><Q><D><W><L><A><V><K><E><A><I><K><K><G><N><G><L><P><P><L><D><C><P><R><G><A><P><I><R><R><L><D><P><E><L><S><L><P><E><T><Q><S><R><A><S><R><P><W><P><F><S><L><L><V><R><G><G><P><L><P><E><G><L><L><S><E><D><L><A><P><E><D><N><T><S><S><L><T><H><G><A><G><Q><V><L><C><G><N><P><T><K><G><L><R><E><R><R><H><Q><C><Q><A><R><E><P><P><E><Q><L><P><Q><H><R><P><G><D><P><A><A><S><T><S><T><P><E><P><D><P><A><D><S><S><D><F><L><A><L><A><G><L><R><A><W><R><E><H><G><V><R><P><L><P><Y><R><H><P><E><S><Q><Q><E><G><A><V><A><P><W><G><P><R><R><V><P><E><E><Q><V><H><Q><A><E><P><K><T><P><S><S><P><P><S><L><A><S><E><P><S><G><T><S><S><Q><H><L><V><P><S><P><P><K><H><P><R><P><R><D><S><G><S><S><S><P><R><W><S><T><D><L><Q><S><R><G><R><R><L><R><V><L><G><S><W><G><P><G><L><G><D><G><V><A><A><V><P><V><L><R><A><L><E><V><A><S><R><L><S><P><R><A><Q><G><C><P><G><P><K><P><A><P><D><A><A><A><R><P><P><R><A><A><E><L><S><H><P><S><P><V><P><T>
Required for the assembly of dynein arms.<BOP>
Q8IYG6
Q8N883
ZN614_HUMAN
Zinc finger protein 614
Homo
<M><I><K><T><Q><E><S><L><T><L><E><D><V><A><V><E><F><S><W><E><E><W><Q><L><L><D><T><A><Q><K><N><L><Y><R><D><V><M><V><E><N><Y><N><H><L><V><S><L><G><Y><Q><T><S><K><P><D><V><L><S><K><L><A><H><G><Q><E><P><W><T><T><D><A><K><I><Q><N><K><N><C><P><G><I><G><K><V><D><S><H><L><Q><E><H><S><P><N><Q><R><L><L><K><S><V><Q><Q><C><N><G><Q><N><T><L><R><N><I><V><H><L><S><K><T><H><F><P><I><V><Q><N><H><D><T><F><D><L><Y><R><K><N><L><K><S><S><L><S><L><I><N><Q><K><R><R><H><G><I><N><N><P><V><E><F><I><G><G><E><K><T><L><L><H><G><K><H><E><R><T><H><T><K><T><R><F><S><E><N><A><K><C><I><H><T><K><F><Q><V><F><K><H><Q><R><T><Q><K><I><E><K><P><H><A><C><I><E><C><E><Q><T><F><L><R><K><S><Q><L><I><Y><H><E><N><I><C><I><Q><E><N><P><G><S><G><Q><C><E><K><L><S><R><S><V><L><F><T><K><H><L><K><T><N><T><T><D><K><I><C><I><P><N><E><Y><R><K><G><S><T><V><K><S><S><L><I><T><H><Q><Q><T><H><T><E><E><K><S><Y><M><C><S><E><C><G><K><G><F><T><M><K><R><Y><L><I><A><H><Q><R><T><H><S><G><E><K><P><Y><V><C><K><E><C><G><K><G><F><T><V><K><S><N><L><I><V><H><Q><R><T><H><T><G><E><K><P><Y><I><C><S><E><C><G><K><G><F><T><M><K><R><Y><L><V><V><H><Q><R><T><H><T><G><E><K><P><Y><M><C><S><E><C><G><K><G><F><T><V><K><S><N><L><I><V><H><Q><R><S><H><T><G><E><K><S><Y><I><C><S><E><C><G><K><G><F><T><V><K><R><T><L><V><I><H><Q><R><T><H><T><G><E><K><S><Y><I><C><N><E><C><G><K><G><F><T><T><K><R><T><L><I><I><H><Q><R><T><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><S><Q><K><I><C><L><I><Q><H><E><R><C><H><T><G><K><T><P><F><V><C><T><E><C><G><K><S><Y><S><H><K><Y><G><L><I><T><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><T><T><K><S><V><L><N><V><H><Q><R><T><H><T><G><E><R><P><Y><G><C><S><D><C><E><K><A><F><S><H><L><S><N><L><V><K><H><K><K><M><H><T><R><E><M><G><R><I><S><Q><V><E><N><S><C><N><G><E><S><Q><L><L><P><Y><K>
May be involved in transcriptional regulation.<BOP>
Q8N883
Q8IUR0
TPPC5_HUMAN
Trafficking protein particle complex subunit 5
Homo
<M><E><A><R><F><T><R><G><K><S><A><L><L><E><R><A><L><A><R><P><R><T><E><V><S><L><S><A><F><A><L><L><F><S><E><L><V><Q><H><C><Q><S><R><V><F><S><V><A><E><L><Q><S><R><L><A><A><L><G><R><Q><V><G><A><R><V><L><D><A><L><V><A><R><E><K><G><A><R><R><E><T><K><V><L><G><A><L><L><F><V><K><G><A><V><W><K><A><L><F><G><K><E><A><D><K><L><E><Q><A><N><D><D><A><R><T><F><Y><I><I><E><R><E><P><L><I><N><T><Y><I><S><V><P><K><E><N><S><T><L><N><C><A><S><F><T><A><G><I><V><E><A><V><L><T><H><S><G><F><P><A><K><V><T><A><H><W><H><K><G><T><T><L><M><I><K><F><E><E><A><V><I><A><R><D><R><A><L><E><G><R>
May play a role in vesicular transport from endoplasmic reticulum to Golgi.<BOP>
Q8IUR0
A6NFH5
FBP12_HUMAN
Fatty acid-binding protein 12
Homo
<M><I><D><Q><L><Q><G><T><W><K><S><I><S><C><E><N><S><E><D><Y><M><K><E><L><G><I><G><R><A><S><R><K><L><G><R><L><A><K><P><T><V><T><I><S><T><D><G><D><V><I><T><I><K><T><K><S><I><F><K><N><N><E><I><S><F><K><L><G><E><E><F><E><E><I><T><P><G><G><H><K><T><K><S><K><V><T><L><D><K><E><S><L><I><Q><V><Q><D><W><D><G><K><E><T><T><I><T><R><K><L><V><D><G><K><M><V><V><E><S><T><V><N><S><V><I><C><T><R><T><Y><E><K><V><S><S><N><S><V><S><N><S>
May play a role in lipid transport.<BOP>
A6NFH5
Q9NYV9
T2R13_HUMAN
Taste receptor family B member 3
Homo
<M><E><S><A><L><P><S><I><F><T><L><V><I><I><A><E><F><I><I><G><N><L><S><N><G><F><I><V><L><I><N><C><I><D><W><V><S><K><R><E><L><S><S><V><D><K><L><L><I><I><L><A><I><S><R><I><G><L><I><W><E><I><L><V><S><W><F><L><A><L><H><Y><L><A><I><F><V><S><G><T><G><L><R><I><M><I><F><S><W><I><V><S><N><H><F><N><L><W><L><A><T><I><F><S><I><F><Y><L><L><K><I><A><S><F><S><S><P><A><F><L><Y><L><K><W><R><V><N><K><V><I><L><M><I><L><L><G><T><L><V><F><L><F><L><N><L><I><Q><I><N><M><H><I><K><D><W><L><D><R><Y><E><R><N><T><T><W><N><F><S><M><S><D><F><E><T><F><S><V><S><V><K><F><T><M><T><M><F><S><L><T><P><F><T><V><A><F><I><S><F><L><L><L><I><F><S><L><Q><K><H><L><Q><K><M><Q><L><N><Y><K><G><H><R><D><P><R><T><K><V><H><T><N><A><L><K><I><V><I><S><F><L><L><F><Y><A><S><F><F><L><C><V><L><I><S><W><I><S><E><L><Y><Q><N><T><V><I><Y><M><L><C><E><T><I><G><V><F><S><P><S><S><H><S><F><L><L><I><L><G><N><A><K><L><R><Q><A><F><L><L><V><A><A><K><V><W><A><K><R>
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.<BOP>
Q9NYV9
Q08431
MFGM_HUMAN
Medin
Homo
<M><P><R><P><R><L><L><A><A><L><C><G><A><L><L><C><A><P><S><L><L><V><A><L><D><I><C><S><K><N><P><C><H><N><G><G><L><C><E><E><I><S><Q><E><V><R><G><D><V><F><P><S><Y><T><C><T><C><L><K><G><Y><A><G><N><H><C><E><T><K><C><V><E><P><L><G><L><E><N><G><N><I><A><N><S><Q><I><A><A><S><S><V><R><V><T><F><L><G><L><Q><H><W><V><P><E><L><A><R><L><N><R><A><G><M><V><N><A><W><T><P><S><S><N><D><D><N><P><W><I><Q><V><N><L><L><R><R><M><W><V><T><G><V><V><T><Q><G><A><S><R><L><A><S><H><E><Y><L><K><A><F><K><V><A><Y><S><L><N><G><H><E><F><D><F><I><H><D><V><N><K><K><H><K><E><F><V><G><N><W><N><K><N><A><V><H><V><N><L><F><E><T><P><V><E><A><Q><Y><V><R><L><Y><P><T><S><C><H><T><A><C><T><L><R><F><E><L><L><G><C><E><L><N><G><C><A><N><P><L><G><L><K><N><N><S><I><P><D><K><Q><I><T><A><S><S><S><Y><K><T><W><G><L><H><L><F><S><W><N><P><S><Y><A><R><L><D><K><Q><G><N><F><N><A><W><V><A><G><S><Y><G><N><D><Q><W><L><Q><V><D><L><G><S><S><K><E><V><T><G><I><I><T><Q><G><A><R><N><F><G><S><V><Q><F><V><A><S><Y><K><V><A><Y><S><N><D><S><A><N><W><T><E><Y><Q><D><P><R><T><G><S><S><K><I><F><P><G><N><W><D><N><H><S><H><K><K><N><L><F><E><T><P><I><L><A><R><Y><V><R><I><L><P><V><A><W><H><N><R><I><A><L><R><L><E><L><L><G><C>
Main constituent of aortic medial amyloid.<BOP>
Q08431
Q96QD9
UIF_HUMAN
Forty-two-three domain-containing protein 1
Homo
<M><N><R><F><G><T><R><L><V><G><A><T><A><T><S><S><P><P><P><K><A><R><S><N><E><N><L><D><K><I><D><M><S><L><D><D><I><I><K><L><N><R><K><E><G><K><K><Q><N><F><P><R><L><N><R><R><L><L><Q><Q><S><G><A><Q><Q><F><R><M><R><V><R><W><G><I><Q><Q><N><S><G><F><G><K><T><S><L><N><R><R><G><R><V><M><P><G><K><R><R><P><N><G><V><I><T><G><L><A><A><R><K><T><T><G><I><R><K><G><I><S><P><M><N><R><P><P><L><S><D><K><N><I><E><Q><Y><F><P><V><L><K><R><K><A><N><L><L><R><Q><N><E><G><Q><R><K><P><V><A><V><L><K><R><P><S><Q><L><S><R><K><N><N><I><P><A><N><F><T><R><S><G><N><K><L><N><H><Q><K><D><T><R><Q><A><T><F><L><F><R><R><G><L><K><V><Q><A><Q><L><N><T><E><Q><L><L><D><D><V><V><A><K><R><T><R><Q><W><R><T><S><T><T><N><G><G><I><L><T><V><S><I><D><N><P><G><A><V><Q><C><P><V><T><Q><K><P><R><L><T><R><T><A><V><P><S><F><L><T><K><R><E><Q><S><D><V><K><K><V><P><K><G><V><P><L><Q><F><D><I><N><S><V><G><K><Q><T><G><M><T><L><N><E><R><F><G><I><L><K><E><Q><R><A><T><L><T><Y><N><K><G><G><S><R><F><V><T><V><G>
Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.<BOP>
Q96QD9
Q30201
HFE_HUMAN
HLA-H
Homo
<M><G><P><R><A><R><P><A><L><L><L><L><M><L><L><Q><T><A><V><L><Q><G><R><L><L><R><S><H><S><L><H><Y><L><F><M><G><A><S><E><Q><D><L><G><L><S><L><F><E><A><L><G><Y><V><D><D><Q><L><F><V><F><Y><D><H><E><S><R><R><V><E><P><R><T><P><W><V><S><S><R><I><S><S><Q><M><W><L><Q><L><S><Q><S><L><K><G><W><D><H><M><F><T><V><D><F><W><T><I><M><E><N><H><N><H><S><K><E><S><H><T><L><Q><V><I><L><G><C><E><M><Q><E><D><N><S><T><E><G><Y><W><K><Y><G><Y><D><G><Q><D><H><L><E><F><C><P><D><T><L><D><W><R><A><A><E><P><R><A><W><P><T><K><L><E><W><E><R><H><K><I><R><A><R><Q><N><R><A><Y><L><E><R><D><C><P><A><Q><L><Q><Q><L><L><E><L><G><R><G><V><L><D><Q><Q><V><P><P><L><V><K><V><T><H><H><V><T><S><S><V><T><T><L><R><C><R><A><L><N><Y><Y><P><Q><N><I><T><M><K><W><L><K><D><K><Q><P><M><D><A><K><E><F><E><P><K><D><V><L><P><N><G><D><G><T><Y><Q><G><W><I><T><L><A><V><P><P><G><E><E><Q><R><Y><T><C><Q><V><E><H><P><G><L><D><Q><P><L><I><V><I><W><E><P><S><P><S><G><T><L><V><I><G><V><I><S><G><I><A><V><F><V><V><I><L><F><I><G><I><L><F><I><I><L><R><K><R><Q><G><S><R><G><A><M><G><H><Y><V><L><A><E><R><E>
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.<BOP>
Q30201
Q13126
MTAP_HUMAN
5'-methylthioadenosine phosphorylase
Homo
<M><A><S><G><T><T><T><T><A><V><K><I><G><I><I><G><G><T><G><L><D><D><P><E><I><L><E><G><R><T><E><K><Y><V><D><T><P><F><G><K><P><S><D><A><L><I><L><G><K><I><K><N><V><D><C><V><L><L><A><R><H><G><R><Q><H><T><I><M><P><S><K><V><N><Y><Q><A><N><I><W><A><L><K><E><E><G><C><T><H><V><I><V><T><T><A><C><G><S><L><R><E><E><I><Q><P><G><D><I><V><I><I><D><Q><F><I><D><R><T><T><M><R><P><Q><S><F><Y><D><G><S><H><S><C><A><R><G><V><C><H><I><P><M><A><E><P><F><C><P><K><T><R><E><V><L><I><E><T><A><K><K><L><G><L><R><C><H><S><K><G><T><M><V><T><I><E><G><P><R><F><S><S><R><A><E><S><F><M><F><R><T><W><G><A><D><V><I><N><M><T><T><V><P><E><V><V><L><A><K><E><A><G><I><C><Y><A><S><I><A><M><A><T><D><Y><D><C><W><K><E><H><E><E><A><V><S><V><D><R><V><L><K><T><L><K><E><N><A><N><K><A><K><S><L><L><L><T><T><I><P><Q><I><G><S><T><E><W><S><E><T><L><H><N><L><K><N><M><A><Q><F><S><V><L><L><P><R><H>
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<BOP>
Q13126
A8MW95
BECN2_HUMAN
Beclin-1-like protein 1
Homo
<M><S><S><I><R><F><L><C><Q><R><C><H><Q><A><L><K><L><S><G><S><S><E><S><R><S><L><P><A><A><P><A><P><T><S><G><Q><A><E><P><G><D><T><R><E><P><G><V><T><T><R><E><V><T><D><A><E><E><Q><Q><D><G><A><S><S><R><S><P><P><G><D><G><S><V><S><K><G><H><A><N><I><F><T><L><L><G><E><L><G><A><M><H><M><L><S><S><I><Q><K><A><A><G><D><I><F><D><I><V><S><G><Q><A><V><V><D><H><P><L><C><E><E><C><T><D><S><L><L><E><Q><L><D><I><Q><L><A><L><T><E><A><D><S><Q><N><Y><Q><R><C><L><E><T><G><E><L><A><T><S><E><D><E><A><A><A><L><R><A><E><L><R><D><L><E><L><E><E><A><R><L><V><Q><E><L><E><D><V><D><R><N><N><A><R><A><A><A><D><L><Q><A><A><Q><A><E><A><A><E><L><D><Q><Q><E><R><Q><H><Y><R><D><Y><S><A><L><K><R><Q><Q><L><E><L><L><D><Q><L><G><N><V><E><N><Q><L><Q><Y><A><R><V><Q><R><D><R><L><K><E><I><N><C><F><T><A><T><F><E><I><W><V><E><G><P><L><G><V><I><N><N><F><R><L><G><R><L><P><T><V><R><V><G><W><N><E><I><N><T><A><W><G><Q><A><A><L><L><L><L><T><L><A><N><T><I><G><L><Q><F><Q><R><Y><R><L><I><P><C><G><N><H><S><Y><L><K><S><L><T><D><D><R><T><E><L><P><L><F><C><Y><G><G><Q><D><V><F><L><N><N><K><Y><D><R><A><M><V><A><F><L><D><C><M><Q><Q><F><K><E><E><A><E><K><G><E><L><G><L><S><L><P><Y><G><I><Q><V><E><T><G><L><M><E><D><V><G><G><R><G><E><C><Y><S><I><R><T><H><L><N><T><Q><E><L><W><T><K><A><L><K><F><M><L><I><N><F><K><W><S><L><I><W><V><A><S><R><Y><Q><K>
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.<BOP>
A8MW95
Q8NBQ5
DHB11_HUMAN
Short chain dehydrogenase/reductase family 16C member 2
Homo
<M><K><F><L><L><D><I><L><L><L><L><P><L><L><I><V><C><S><L><E><S><F><V><K><L><F><I><P><K><R><R><K><S><V><T><G><E><I><V><L><I><T><G><A><G><H><G><I><G><R><L><T><A><Y><E><F><A><K><L><K><S><K><L><V><L><W><D><I><N><K><H><G><L><E><E><T><A><A><K><C><K><G><L><G><A><K><V><H><T><F><V><V><D><C><S><N><R><E><D><I><Y><S><S><A><K><K><V><K><A><E><I><G><D><V><S><I><L><V><N><N><A><G><V><V><Y><T><S><D><L><F><A><T><Q><D><P><Q><I><E><K><T><F><E><V><N><V><L><A><H><F><W><T><T><K><A><F><L><P><A><M><T><K><N><N><H><G><H><I><V><T><V><A><S><A><A><G><H><V><S><V><P><F><L><L><A><Y><C><S><S><K><F><A><A><V><G><F><H><K><T><L><T><D><E><L><A><A><L><Q><I><T><G><V><K><T><T><C><L><C><P><N><F><V><N><T><G><F><I><K><N><P><S><T><S><L><G><P><T><L><E><P><E><E><V><V><N><R><L><M><H><G><I><L><T><E><Q><K><M><I><F><I><P><S><S><I><A><F><L><T><T><L><E><R><I><L><P><E><R><F><L><A><V><L><K><Q><K><I><S><V><K><F><D><A><V><I><G><Y><K><M><K><A><Q>
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.<BOP>
Q8NBQ5
Q8IWL1
SFPA2_HUMAN
Collectin-5
Homo
<M><W><L><C><P><L><A><L><T><L><I><L><M><A><A><S><G><A><A><C><E><V><K><D><V><C><V><G><S><P><G><I><P><G><T><P><G><S><H><G><L><P><G><R><D><G><R><D><G><V><K><G><D><P><G><P><P><G><P><M><G><P><P><G><E><T><P><C><P><P><G><N><N><G><L><P><G><A><P><G><V><P><G><E><R><G><E><K><G><E><A><G><E><R><G><P><P><G><L><P><A><H><L><D><E><E><L><Q><A><T><L><H><D><F><R><H><Q><I><L><Q><T><R><G><A><L><S><L><Q><G><S><I><M><T><V><G><E><K><V><F><S><S><N><G><Q><S><I><T><F><D><A><I><Q><E><A><C><A><R><A><G><G><R><I><A><V><P><R><N><P><E><E><N><E><A><I><A><S><F><V><K><K><Y><N><T><Y><A><Y><V><G><L><T><E><G><P><S><P><G><D><F><R><Y><S><D><G><T><P><V><N><Y><T><N><W><Y><R><G><E><P><A><G><R><G><K><E><Q><C><V><E><M><Y><T><D><G><Q><W><N><D><R><N><C><L><Y><S><R><L><T><I><C><E><F>
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.<BOP>
Q8IWL1
Q9UNF1
MAGD2_HUMAN
MAGE-D2 antigen
Homo
<M><S><D><T><S><E><S><G><A><G><L><T><R><F><Q><A><E><A><S><E><K><D><S><S><S><M><M><Q><T><L><L><T><V><T><Q><N><V><E><V><P><E><T><P><K><A><S><K><A><L><E><V><S><E><D><V><K><V><S><K><A><S><G><V><S><K><A><T><E><V><S><K><T><P><E><A><R><E><A><P><A><T><Q><A><S><S><T><T><Q><L><T><D><T><Q><V><L><A><A><E><N><K><S><L><A><A><D><T><K><K><Q><N><A><D><P><Q><A><V><T><M><P><A><T><E><T><K><K><V><S><H><V><A><D><T><K><V><N><T><K><A><Q><E><T><E><A><A><P><S><Q><A><P><A><D><E><P><E><P><E><S><A><A><A><Q><S><Q><E><N><Q><D><T><R><P><K><V><K><A><K><K><A><R><K><V><K><H><L><D><G><E><E><D><G><S><S><D><Q><S><Q><A><S><G><T><T><G><G><R><R><V><S><K><A><L><M><A><S><M><A><R><R><A><S><R><G><P><I><A><F><W><A><R><R><A><S><R><T><R><L><A><A><W><A><R><R><A><L><L><S><L><R><S><P><K><A><R><R><G><K><A><R><R><R><A><A><K><L><Q><S><S><Q><E><P><E><A><P><P><P><R><D><V><A><L><L><Q><G><R><A><N><D><L><V><K><Y><L><L><A><K><D><Q><T><K><I><P><I><K><R><S><D><M><L><K><D><I><I><K><E><Y><T><D><V><Y><P><E><I><I><E><R><A><G><Y><S><L><E><K><V><F><G><I><Q><L><K><E><I><D><K><N><D><H><L><Y><I><L><L><S><T><L><E><P><T><D><A><G><I><L><G><T><T><K><D><S><P><K><L><G><L><L><M><V><L><L><S><I><I><F><M><N><G><N><R><S><S><E><A><V><I><W><E><V><L><R><K><L><G><L><R><P><G><I><H><H><S><L><F><G><D><V><K><K><L><I><T><D><E><F><V><K><Q><K><Y><L><D><Y><A><R><V><P><N><S><N><P><P><E><Y><E><F><F><W><G><L><R><S><Y><Y><E><T><S><K><M><K><V><L><K><F><A><C><K><V><Q><K><K><D><P><K><E><W><A><A><Q><Y><R><E><A><M><E><A><D><L><K><A><A><A><E><A><A><A><E><A><K><A><R><A><E><I><R><A><R><M><G><I><G><L><G><S><E><N><A><A><G><P><C><N><W><D><E><A><D><I><G><P><W><A><K><A><R><I><Q><A><G><A><E><A><K><A><K><A><Q><E><S><G><S><A><S><T><G><A><S><T><S><T><N><N><S><A><S><A><S><A><S><T><S><G><G><F><S><A><G><A><S><L><T><A><T><L><T><F><G><L><F><A><G><L><G><G><A><G><A><S><T><S><G><S><S><G><A><C><G><F><S><Y><K>
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.<BOP>
Q9UNF1
P02787
TRFE_HUMAN
Siderophilin
Homo
<M><R><L><A><V><G><A><L><L><V><C><A><V><L><G><L><C><L><A><V><P><D><K><T><V><R><W><C><A><V><S><E><H><E><A><T><K><C><Q><S><F><R><D><H><M><K><S><V><I><P><S><D><G><P><S><V><A><C><V><K><K><A><S><Y><L><D><C><I><R><A><I><A><A><N><E><A><D><A><V><T><L><D><A><G><L><V><Y><D><A><Y><L><A><P><N><N><L><K><P><V><V><A><E><F><Y><G><S><K><E><D><P><Q><T><F><Y><Y><A><V><A><V><V><K><K><D><S><G><F><Q><M><N><Q><L><R><G><K><K><S><C><H><T><G><L><G><R><S><A><G><W><N><I><P><I><G><L><L><Y><C><D><L><P><E><P><R><K><P><L><E><K><A><V><A><N><F><F><S><G><S><C><A><P><C><A><D><G><T><D><F><P><Q><L><C><Q><L><C><P><G><C><G><C><S><T><L><N><Q><Y><F><G><Y><S><G><A><F><K><C><L><K><D><G><A><G><D><V><A><F><V><K><H><S><T><I><F><E><N><L><A><N><K><A><D><R><D><Q><Y><E><L><L><C><L><D><N><T><R><K><P><V><D><E><Y><K><D><C><H><L><A><Q><V><P><S><H><T><V><V><A><R><S><M><G><G><K><E><D><L><I><W><E><L><L><N><Q><A><Q><E><H><F><G><K><D><K><S><K><E><F><Q><L><F><S><S><P><H><G><K><D><L><L><F><K><D><S><A><H><G><F><L><K><V><P><P><R><M><D><A><K><M><Y><L><G><Y><E><Y><V><T><A><I><R><N><L><R><E><G><T><C><P><E><A><P><T><D><E><C><K><P><V><K><W><C><A><L><S><H><H><E><R><L><K><C><D><E><W><S><V><N><S><V><G><K><I><E><C><V><S><A><E><T><T><E><D><C><I><A><K><I><M><N><G><E><A><D><A><M><S><L><D><G><G><F><V><Y><I><A><G><K><C><G><L><V><P><V><L><A><E><N><Y><N><K><S><D><N><C><E><D><T><P><E><A><G><Y><F><A><I><A><V><V><K><K><S><A><S><D><L><T><W><D><N><L><K><G><K><K><S><C><H><T><A><V><G><R><T><A><G><W><N><I><P><M><G><L><L><Y><N><K><I><N><H><C><R><F><D><E><F><F><S><E><G><C><A><P><G><S><K><K><D><S><S><L><C><K><L><C><M><G><S><G><L><N><L><C><E><P><N><N><K><E><G><Y><Y><G><Y><T><G><A><F><R><C><L><V><E><K><G><D><V><A><F><V><K><H><Q><T><V><P><Q><N><T><G><G><K><N><P><D><P><W><A><K><N><L><N><E><K><D><Y><E><L><L><C><L><D><G><T><R><K><P><V><E><E><Y><A><N><C><H><L><A><R><A><P><N><H><A><V><V><T><R><K><D><K><E><A><C><V><H><K><I><L><R><Q><Q><Q><H><L><F><G><S><N><V><T><D><C><S><G><N><F><C><L><F><R><S><E><T><K><D><L><L><F><R><D><D><T><V><C><L><A><K><L><H><D><R><N><T><Y><E><K><Y><L><G><E><E><Y><V><K><A><V><G><N><L><R><K><C><S><T><S><S><L><L><E><A><C><T><F><R><R><P>
(Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.<BOP>
P02787
Q9NR80
ARHG4_HUMAN
APC-stimulated guanine nucleotide exchange factor 1
Homo
<M><P><W><E><E><P><A><G><E><K><P><S><C><S><H><S><Q><K><A><F><H><M><E><P><A><Q><K><P><C><F><T><T><D><M><V><T><W><A><L><L><C><I><S><A><E><T><V><R><G><E><A><P><S><Q><P><R><G><I><P><H><R><S><P><V><S><V><D><D><L><W><L><E><K><T><Q><R><K><K><L><Q><K><Q><A><H><V><E><R><R><L><H><I><G><A><V><H><K><D><G><V><K><C><W><R><K><T><I><I><T><S><P><E><S><L><N><L><P><R><R><S><H><P><L><S><Q><S><A><P><T><G><L><N><H><M><G><W><P><E><H><T><P><G><T><A><M><P><D><G><A><L><D><T><A><V><C><A><D><E><V><G><S><E><E><D><L><Y><D><D><L><H><S><S><S><H><H><Y><S><H><P><G><G><G><G><E><Q><L><A><I><N><E><L><I><S><D><G><S><V><V><C><A><E><A><L><W><D><H><V><T><M><D><D><Q><E><L><G><F><K><A><G><D><V><I><E><V><M><D><A><T><N><R><E><W><W><W><G><R><V><A><D><G><E><G><W><F><P><A><S><F><V><R><L><R><V><N><Q><D><E><P><A><D><D><D><A><P><L><A><G><N><S><G><A><E><D><G><G><A><E><A><Q><S><S><K><D><Q><M><R><T><N><V><I><N><E><I><L><S><T><E><R><D><Y><I><K><H><L><R><D><I><C><E><G><Y><V><R><Q><C><R><K><R><A><D><M><F><S><E><E><Q><L><R><T><I><F><G><N><I><E><D><I><Y><R><C><Q><K><A><F><V><K><A><L><E><Q><R><F><N><R><E><R><P><H><L><S><E><L><G><A><C><F><L><E><H><Q><A><D><F><Q><I><Y><S><E><Y><C><N><N><H><P><N><A><C><V><E><L><S><R><L><T><K><L><S><K><Y><V><Y><F><F><E><A><C><R><L><L><Q><K><M><I><D><I><S><L><D><G><F><L><L><T><P><V><Q><K><I><C><K><Y><P><L><Q><L><A><E><L><L><K><Y><T><H><P><Q><H><R><D><F><K><D><V><E><A><A><L><H><A><M><K><N><V><A><Q><L><I><N><E><R><K><R><R><L><E><N><I><D><K><I><A><Q><W><Q><S><S><I><E><D><W><E><G><E><D><L><L><V><R><S><S><E><L><I><Y><S><G><E><L><T><R><V><T><Q><P><Q><A><K><S><Q><Q><R><M><F><F><L><F><D><H><Q><L><I><Y><C><K><K><D><L><L><R><R><D><V><L><Y><Y><K><G><R><L><D><M><D><G><L><E><V><V><D><L><E><D><G><K><D><R><D><L><H><V><S><I><K><N><A><F><R><L><H><R><G><A><T><G><D><S><H><L><L><C><T><R><K><P><E><Q><K><Q><R><W><L><K><A><F><A><R><E><R><E><Q><V><Q><L><D><Q><E><T><G><F><S><I><T><E><L><Q><R><K><Q><A><M><L><N><A><S><K><Q><Q><V><T><G><K><P><K><A><V><G><R><P><C><Y><L><T><R><Q><K><H><P><A><L><P><S><N><R><P><Q><Q><Q><V><L><V><L><A><E><P><R><R><K><P><S><T><F><W><H><S><I><S><R><L><A><P><F><R><K>
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.<BOP>
Q9NR80
Q9BYR8
KRA31_HUMAN
Keratin-associated protein 3.1
Homo
<M><Y><C><C><A><L><R><S><C><S><V><P><T><G><P><A><T><T><F><C><S><F><D><K><S><C><R><C><G><V><C><L><P><S><T><C><P><H><E><I><S><L><L><Q><P><I><C><C><D><T><C><P><P><P><C><C><K><P><D><T><Y><V><P><T><C><W><L><L><N><N><C><H><P><T><P><G><L><S><G><I><N><L><T><T><Y><V><Q><P><G><C><E><S><P><C><E><P><R><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BYR8
P39748
FEN1_HUMAN
Maturation factor 1
Homo
<M><G><I><Q><G><L><A><K><L><I><A><D><V><A><P><S><A><I><R><E><N><D><I><K><S><Y><F><G><R><K><V><A><I><D><A><S><M><S><I><Y><Q><F><L><I><A><V><R><Q><G><G><D><V><L><Q><N><E><E><G><E><T><T><S><H><L><M><G><M><F><Y><R><T><I><R><M><M><E><N><G><I><K><P><V><Y><V><F><D><G><K><P><P><Q><L><K><S><G><E><L><A><K><R><S><E><R><R><A><E><A><E><K><Q><L><Q><Q><A><Q><A><A><G><A><E><Q><E><V><E><K><F><T><K><R><L><V><K><V><T><K><Q><H><N><D><E><C><K><H><L><L><S><L><M><G><I><P><Y><L><D><A><P><S><E><A><E><A><S><C><A><A><L><V><K><A><G><K><V><Y><A><A><A><T><E><D><M><D><C><L><T><F><G><S><P><V><L><M><R><H><L><T><A><S><E><A><K><K><L><P><I><Q><E><F><H><L><S><R><I><L><Q><E><L><G><L><N><Q><E><Q><F><V><D><L><C><I><L><L><G><S><D><Y><C><E><S><I><R><G><I><G><P><K><R><A><V><D><L><I><Q><K><H><K><S><I><E><E><I><V><R><R><L><D><P><N><K><Y><P><V><P><E><N><W><L><H><K><E><A><H><Q><L><F><L><E><P><E><V><L><D><P><E><S><V><E><L><K><W><S><E><P><N><E><E><E><L><I><K><F><M><C><G><E><K><Q><F><S><E><E><R><I><R><S><G><V><K><R><L><S><K><S><R><Q><G><S><T><Q><G><R><L><D><D><F><F><K><V><T><G><S><L><S><S><A><K><R><K><E><P><E><P><K><G><S><T><K><K><K><A><K><T><G><A><A><G><K><F><K><R><G><K>
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.<BOP>
P39748
Q86TJ2
TAD2B_HUMAN
ADA2-like protein beta
Homo
<M><A><E><L><G><K><K><Y><C><V><Y><C><L><A><E><V><S><P><L><R><F><R><C><T><E><C><Q><D><I><E><L><C><P><E><C><F><S><A><G><A><E><I><G><H><H><R><R><Y><H><G><Y><Q><L><V><D><G><G><R><F><T><L><W><G><P><E><A><E><G><G><W><T><S><R><E><E><Q><L><L><L><D><A><I><E><Q><F><G><F><G><N><W><E><D><M><A><A><H><V><G><A><S><R><T><P><Q><E><V><M><E><H><Y><V><S><M><Y><I><H><G><N><L><G><K><A><C><I><P><D><T><I><P><N><R><V><T><D><H><T><C><P><S><G><G><P><L><S><P><S><L><T><T><P><L><P><P><L><D><I><S><V><A><E><Q><Q><Q><L><G><Y><M><P><L><R><D><D><Y><E><I><E><Y><D><Q><D><A><E><T><L><I><S><G><L><S><V><N><Y><D><D><D><D><V><E><I><E><L><K><R><A><H><V><D><M><Y><V><R><K><L><K><E><R><Q><R><R><K><N><I><A><R><D><Y><N><L><V><P><A><F><L><G><K><D><K><K><E><K><E><K><A><L><K><R><K><I><T><K><E><E><K><E><L><R><L><K><L><R><P><L><Y><Q><F><M><S><C><K><E><F><D><D><L><F><E><N><M><H><K><E><K><M><L><R><A><K><I><R><E><L><Q><R><Y><R><R><N><G><I><T><K><M><E><E><S><A><E><Y><E><A><A><R><H><K><R><E><K><R><K><E><N><K><N><L><A><G><S><K><R><G><K><E><D><G><K><D><S><E><F><A><A><I><E><N><L><P><G><F><E><L><L><S><D><R><E><K><V><L><C><S><S><L><N><L><S><P><A><R><Y><V><T><V><K><T><I><I><I><K><D><H><L><Q><K><R><Q><G><I><P><S><K><S><R><L><P><S><Y><L><D><K><V><L><K><K><R><I><L><N><F><L><T><E><S><G><W><I><S><R><D><A><S>
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.<BOP>
Q86TJ2
P01568
IFN21_HUMAN
Interferon alpha-F
Homo
<M><A><L><S><F><S><L><L><M><A><V><L><V><L><S><Y><K><S><I><C><S><L><G><C><D><L><P><Q><T><H><S><L><G><N><R><R><A><L><I><L><L><A><Q><M><G><R><I><S><P><F><S><C><L><K><D><R><H><D><F><G><F><P><Q><E><E><F><D><G><N><Q><F><Q><K><A><Q><A><I><S><V><L><H><E><M><I><Q><Q><T><F><N><L><F><S><T><K><D><S><S><A><T><W><E><Q><S><L><L><E><K><F><S><T><E><L><N><Q><Q><L><N><D><L><E><A><C><V><I><Q><E><V><G><V><E><E><T><P><L><M><N><V><D><S><I><L><A><V><K><K><Y><F><Q><R><I><T><L><Y><L><T><E><K><K><Y><S><P><C><A><W><E><V><V><R><A><E><I><M><R><S><F><S><L><S><K><I><F><Q><E><R><L><R><R><K><E>
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.<BOP>
P01568
Q8NI37
PPTC7_HUMAN
T-cell activation protein phosphatase 2C-like
Homo
<M><F><S><V><L><S><Y><G><R><L><V><A><R><A><V><L><G><G><L><S><Q><T><D><P><R><A><G><G><G><G><G><G><D><Y><G><L><V><T><A><G><C><G><F><G><K><D><F><R><K><G><L><L><K><K><G><A><C><Y><G><D><D><A><C><F><V><A><R><H><R><S><A><D><V><L><G><V><A><D><G><V><G><G><W><R><D><Y><G><V><D><P><S><Q><F><S><G><T><L><M><R><T><C><E><R><L><V><K><E><G><R><F><V><P><S><N><P><I><G><I><L><T><T><S><Y><C><E><L><L><Q><N><K><V><P><L><L><G><S><S><T><A><C><I><V><V><L><D><R><T><S><H><R><L><H><T><A><N><L><G><D><S><G><F><L><V><V><R><G><G><E><V><V><H><R><S><D><E><Q><Q><H><Y><F><N><T><P><F><Q><L><S><I><A><P><P><E><A><E><G><V><V><L><S><D><S><P><D><A><A><D><S><T><S><F><D><V><Q><L><G><D><I><I><L><T><A><T><D><G><L><F><D><N><M><P><D><Y><M><I><L><Q><E><L><K><K><L><K><N><S><N><Y><E><S><I><Q><Q><T><A><R><S><I><A><E><Q><A><H><E><L><A><Y><D><P><N><Y><M><S><P><F><A><Q><F><A><C><D><N><G><L><N><V><R><G><G><K><P><D><D><I><T><V><L><L><S><I><V><A><E><Y><T><D>
Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q . Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation .<BOP>
Q8NI37
P55774
CCL18_HUMAN
CCL18(4-69)
Homo
<M><K><G><L><A><A><A><L><L><V><L><V><C><T><M><A><L><C><S><C><A><Q><V><G><T><N><K><E><L><C><C><L><V><Y><T><S><W><Q><I><P><Q><K><F><I><V><D><Y><S><E><T><S><P><Q><C><P><K><P><G><V><I><L><L><T><K><R><G><R><Q><I><C><A><D><P><N><K><K><W><V><Q><K><Y><I><S><D><L><K><L><N><A>
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.<BOP>
P55774
Q8NGG1
OR8J2_HUMAN
Olfactory receptor 8J2
Homo
<M><A><S><G><N><L><T><W><V><T><E><F><I><L><V><G><V><S><D><D><P><E><L><Q><I><P><L><F><L><V><F><L><V><L><Y><L><L><T><V><A><G><N><L><G><I><I><T><L><T><S><V><D><P><Q><L><Q><T><P><M><Y><F><F><L><R><H><L><A><I><I><N><L><C><N><S><T><V><V><A><P><K><M><L><V><N><F><L><V><T><K><K><T><I><S><Y><Y><G><C><A><A><Q><L><G><G><F><L><V><F><I><V><A><E><I><F><T><L><A><A><M><A><Y><D><R><Y><V><A><I><W><S><P><L><L><Y><A><V><V><V><S><P><K><V><C><R><L><L><V><S><L><T><Y><L><Q><S><L><I><T><A><L><T><V><S><S><C><V><F><S><V><S><Y><C><S><S><N><I><I><N><H><F><Y><C><D><D><V><P><L><L><A><L><S><C><S><D><T><Y><I><P><E><T><A><V><F><I><F><S><G><T><N><L><L><F><S><M><I><V><V><L><I><S><Y><F><N><I><V><I><T><I><L><R><I><R><S><S><E><G><R><Q><K><A><F><S><T><C><A><S><H><M><I><A><V><V><V><F><Y><G><T><L><L><F><M><Y><L><Q><P><R><S><N><H><S><L><D><T><D><K><M><A><S><V><F><Y><T><L><V><I><P><V><L><N><P><L><I><Y><S><L><R><N><K><N><V><K><D><A><L><K><R><F><L><D><N><P><C><R><S><L><K><L><M>
Odorant receptor.<BOP>
Q8NGG1
Q7Z4H3
HDDC2_HUMAN
Hepatitis C virus NS5A-transactivated protein 2
Homo
<M><A><S><V><S><S><A><T><F><S><G><H><G><A><R><S><L><L><Q><F><L><R><L><V><G><Q><L><K><R><V><P><R><T><G><W><V><Y><R><N><V><Q><R><P><E><S><V><S><D><H><M><Y><R><M><A><V><M><A><M><V><I><K><D><D><R><L><N><K><D><R><C><V><R><L><A><L><V><H><D><M><A><E><C><I><V><G><D><I><A><P><A><D><N><I><P><K><E><E><K><H><R><R><E><E><E><A><M><K><Q><I><T><Q><L><L><P><E><D><L><R><K><E><L><Y><E><L><W><E><E><Y><E><T><Q><S><S><A><E><A><K><F><V><K><Q><L><D><Q><C><E><M><I><L><Q><A><S><E><Y><E><D><L><E><H><K><P><G><R><L><Q><D><F><Y><D><S><T><A><G><K><F><N><H><P><E><I><V><Q><L><V><S><E><L><E><A><E><R><S><T><N><I><A><A><A><A><S><E><P><H><S>
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).<BOP>
Q7Z4H3
P31371
FGF9_HUMAN
Heparin-binding growth factor 9
Homo
<M><A><P><L><G><E><V><G><N><Y><F><G><V><Q><D><A><V><P><F><G><N><V><P><V><L><P><V><D><S><P><V><L><L><S><D><H><L><G><Q><S><E><A><G><G><L><P><R><G><P><A><V><T><D><L><D><H><L><K><G><I><L><R><R><R><Q><L><Y><C><R><T><G><F><H><L><E><I><F><P><N><G><T><I><Q><G><T><R><K><D><H><S><R><F><G><I><L><E><F><I><S><I><A><V><G><L><V><S><I><R><G><V><D><S><G><L><Y><L><G><M><N><E><K><G><E><L><Y><G><S><E><K><L><T><Q><E><C><V><F><R><E><Q><F><E><E><N><W><Y><N><T><Y><S><S><N><L><Y><K><H><V><D><T><G><R><R><Y><Y><V><A><L><N><K><D><G><T><P><R><E><G><T><R><T><K><R><H><Q><K><F><T><H><F><L><P><R><P><V><D><P><D><K><V><P><E><L><Y><K><D><I><L><S><Q><S>
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.<BOP>
P31371
Q2MKA7
RSPO1_HUMAN
Roof plate-specific spondin-1
Homo
<M><R><L><G><L><C><V><V><A><L><V><L><S><W><T><H><L><T><I><S><S><R><G><I><K><G><K><R><Q><R><R><I><S><A><E><G><S><Q><A><C><A><K><G><C><E><L><C><S><E><V><N><G><C><L><K><C><S><P><K><L><F><I><L><L><E><R><N><D><I><R><Q><V><G><V><C><L><P><S><C><P><P><G><Y><F><D><A><R><N><P><D><M><N><K><C><I><K><C><K><I><E><H><C><E><A><C><F><S><H><N><F><C><T><K><C><K><E><G><L><Y><L><H><K><G><R><C><Y><P><A><C><P><E><G><S><S><A><A><N><G><T><M><E><C><S><S><P><A><Q><C><E><M><S><E><W><S><P><W><G><P><C><S><K><K><Q><Q><L><C><G><F><R><R><G><S><E><E><R><T><R><R><V><L><H><A><P><V><G><D><H><A><A><C><S><D><T><K><E><T><R><R><C><T><V><R><R><V><P><C><P><E><G><Q><K><R><R><K><G><G><Q><G><R><R><E><N><A><N><R><N><L><A><R><K><E><S><K><E><A><G><A><G><S><R><R><R><K><G><Q><Q><Q><Q><Q><Q><Q><G><T><V><G><P><L><T><S><A><G><P><A>
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors . Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 .<BOP>
Q2MKA7
Q8NGT0
O13C9_HUMAN
Olfactory receptor OR9-13
Homo
<M><E><W><E><N><Q><T><I><L><V><E><F><F><L><K><G><H><S><V><H><P><R><L><E><L><L><F><F><V><L><I><F><I><M><Y><V><V><I><L><L><G><N><G><T><L><I><L><I><S><I><L><D><P><H><L><H><T><P><M><Y><F><F><L><G><N><L><S><F><L><D><I><C><Y><T><T><T><S><I><P><S><T><L><V><S><F><L><S><E><R><K><T><I><S><F><S><G><C><A><V><Q><M><F><L><G><L><A><M><G><T><T><E><C><V><L><L><G><M><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><P><I><I><M><S><K><N><A><Y><V><P><M><A><V><G><S><W><F><A><G><I><V><N><S><A><V><Q><T><T><F><V><V><Q><L><P><F><C><R><K><N><V><I><N><H><F><S><C><E><I><L><A><V><M><K><L><A><C><A><D><I><S><G><N><E><F><L><M><L><V><A><T><I><L><F><T><L><M><P><L><L><L><I><V><I><S><Y><S><L><I><I><S><S><I><L><K><I><H><S><S><E><G><R><S><K><A><F><S><T><C><S><A><H><L><T><V><V><I><I><F><Y><G><T><I><L><F><M><Y><M><K><P><K><S><K><E><T><L><N><S><D><D><L><D><A><T><D><K><I><I><S><M><F><Y><G><V><M><T><P><M><M><N><P><L><I><Y><S><L><R><N><K><D><V><K><E><A><V><K><H><L><P><N><R><R><F><F><S><K>
Odorant receptor.<BOP>
Q8NGT0
Q6ZRF8
RN207_HUMAN
RING finger protein 207
Homo
<M><S><G><A><I><F><G><P><L><E><G><P><S><S><L><D><A><P><S><I><H><P><L><V><C><P><L><C><H><V><Q><Y><E><R><P><C><L><L><D><C><F><H><D><F><C><A><G><C><L><R><G><R><A><T><D><G><R><L><T><C><P><L><C><Q><H><Q><T><V><L><K><G><P><S><G><L><P><P><V><D><R><L><L><Q><F><L><V><D><S><S><G><D><G><V><E><A><V><R><C><A><N><C><D><L><E><C><S><E><Q><D><V><E><T><T><Y><F><C><N><T><C><G><Q><P><L><C><A><R><C><R><D><E><T><H><R><A><R><M><F><A><R><H><D><I><V><A><L><G><Q><R><S><R><D><V><P><Q><K><C><T><L><H><A><E><P><Y><L><L><F><S><T><D><K><K><L><L><L><C><I><R><C><F><R><D><M><Q><K><E><S><R><A><H><C><V><D><L><E><S><A><Y><V><Q><G><C><E><R><L><E><Q><A><V><L><A><V><K><A><L><Q><T><A><T><R><E><A><I><A><L><L><Q><A><M><V><E><E><V><R><H><S><A><A><E><E><E><D><A><I><H><A><L><F><G><S><M><Q><D><R><L><A><E><R><K><A><L><L><L><Q><A><V><Q><S><Q><Y><E><E><K><D><K><A><F><K><E><Q><L><S><H><L><A><T><L><L><P><T><L><Q><V><H><L><V><I><C><S><S><F><L><S><L><A><N><K><A><E><F><L><D><L><G><Y><E><L><M><E><R><L><Q><G><I><V><T><R><P><H><H><L><R><P><I><Q><S><S><K><I><A><S><D><H><R><A><E><F><A><R><C><L><E><P><L><L><L><L><G><P><R><R><V><A><A><A><A><S><G><A><N><T><L><A><G><G><L><G><P><K><A><L><T><G><P><H><C><P><S><P><V><G><K><M><S><G><S><P><V><Q><K><P><T><L><H><R><S><I><S><T><K><V><L><L><A><E><G><E><N><T><P><F><A><E><H><C><R><H><Y><E><D><S><Y><R><H><L><Q><A><E><M><Q><S><L><K><D><Q><V><Q><E><L><H><R><D><L><T><K><H><H><S><L><I><K><A><E><I><M><G><D><V><L><H><K><S><L><Q><L><D><V><Q><I><A><S><E><H><A><S><L><E><G><M><R><V><V><F><Q><E><I><W><E><E><A><Y><Q><R><V><A><N><E><Q><E><I><Y><E><A><Q><L><H><D><L><L><Q><L><R><Q><E><N><A><Y><L><T><T><I><T><K><Q><I><T><P><Y><V><R><S><I><A><K><V><K><E><R><L><E><P><R><F><Q><A><P><V><D><E><Q><S><E><S><L><Q><N><T><H><D><D><S><R><N><N><A><A><S><A><R><N><N><P><G><S><V><P><E><K><R><E><K><T><S><E><P><K><G><N><S><W><A><P><N><G><L><S><E><E><P><L><L><K><N><M><D><H><H><R><S><K><Q><K><N><G><G><D><V><P><T><W><R><E><H><P><T>
Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.<BOP>
Q6ZRF8
Q8WTU0
DDI1_HUMAN
Protein DDI1 homolog 1
Homo
<M><L><I><T><V><Y><C><V><R><R><D><L><S><E><V><T><F><S><L><Q><V><S><P><D><F><E><L><R><N><F><K><V><L><C><E><A><E><S><R><V><P><V><E><E><I><Q><I><I><H><M><E><R><L><L><I><E><D><H><C><S><L><G><S><Y><G><L><K><D><G><D><I><V><V><L><L><Q><K><D><N><V><G><P><R><A><P><G><R><A><P><N><Q><P><R><V><D><F><S><G><I><A><V><P><G><T><S><S><S><R><P><Q><H><P><G><Q><Q><Q><Q><R><T><P><A><A><Q><R><S><Q><G><L><A><S><G><E><K><V><A><G><L><Q><G><L><G><S><P><A><L><I><R><S><M><L><L><S><N><P><H><D><L><S><L><L><K><E><R><N><P><P><L><A><E><A><L><L><S><G><S><L><E><T><F><S><Q><V><L><M><E><Q><Q><R><E><K><A><L><R><E><Q><E><R><L><R><L><Y><T><A><D><P><L><D><R><E><A><Q><A><K><I><E><E><E><I><R><Q><Q><N><I><E><E><N><M><N><I><A><I><E><E><A><P><E><S><F><G><Q><V><T><M><L><Y><I><N><C><K><V><N><G><H><P><L><K><A><F><V><D><S><G><A><Q><M><T><I><M><S><Q><A><C><A><E><R><C><N><I><M><R><L><V><D><R><R><W><A><G><V><A><K><G><V><G><T><Q><R><I><I><G><R><V><H><L><A><Q><I><Q><I><E><G><D><F><L><Q><C><S><F><S><I><L><E><D><Q><P><M><D><M><L><L><G><L><D><M><L><R><R><H><Q><C><S><I><D><L><K><K><N><V><L><V><I><G><T><T><G><T><Q><T><Y><F><L><P><E><G><E><L><P><L><C><S><R><M><V><S><G><Q><D><E><S><S><D><K><E><I><T><H><S><V><M><D><S><G><R><K><E><H>
Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity .<BOP>
Q8WTU0
P03886
NU1M_HUMAN
NADH dehydrogenase subunit 1
Homo
<M><P><M><A><N><L><L><L><L><I><V><P><I><L><I><A><M><A><F><L><M><L><T><E><R><K><I><L><G><Y><M><Q><L><R><K><G><P><N><V><V><G><P><Y><G><L><L><Q><P><F><A><D><A><M><K><L><F><T><K><E><P><L><K><P><A><T><S><T><I><T><L><Y><I><T><A><P><T><L><A><L><T><I><A><L><L><L><W><T><P><L><P><M><P><N><P><L><V><N><L><N><L><G><L><L><F><I><L><A><T><S><S><L><A><V><Y><S><I><L><W><S><G><W><A><S><N><S><N><Y><A><L><I><G><A><L><R><A><V><A><Q><T><I><S><Y><E><V><T><L><A><I><I><L><L><S><T><L><L><M><S><G><S><F><N><L><S><T><L><I><T><T><Q><E><H><L><W><L><L><L><P><S><W><P><L><A><M><M><W><F><I><S><T><L><A><E><T><N><R><T><P><F><D><L><A><E><G><E><S><E><L><V><S><G><F><N><I><E><Y><A><A><G><P><F><A><L><F><F><M><A><E><Y><T><N><I><I><M><M><N><T><L><T><T><T><I><F><L><G><T><T><Y><D><A><L><S><P><E><L><Y><T><T><Y><F><V><T><K><T><L><L><L><T><S><L><F><L><W><I><R><T><A><Y><P><R><F><R><Y><D><Q><L><M><H><L><L><W><K><N><F><L><P><L><T><L><A><L><L><M><W><Y><V><S><M><P><I><T><I><S><S><I><P><P><Q><T>
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I .<BOP>
P03886
Q16671
AMHR2_HUMAN
MIS type II receptor
Homo
<M><L><G><S><L><G><L><W><A><L><L><P><T><A><V><E><A><P><P><N><R><R><T><C><V><F><F><E><A><P><G><V><R><G><S><T><K><T><L><G><E><L><L><D><T><G><T><E><L><P><R><A><I><R><C><L><Y><S><R><C><C><F><G><I><W><N><L><T><Q><D><R><A><Q><V><E><M><Q><G><C><R><D><S><D><E><P><G><C><E><S><L><H><C><D><P><S><P><R><A><H><P><S><P><G><S><T><L><F><T><C><S><C><G><T><D><F><C><N><A><N><Y><S><H><L><P><P><P><G><S><P><G><T><P><G><S><Q><G><P><Q><A><A><P><G><E><S><I><W><M><A><L><V><L><L><G><L><F><L><L><L><L><L><L><L><G><S><I><I><L><A><L><L><Q><R><K><N><Y><R><V><R><G><E><P><V><P><E><P><R><P><D><S><G><R><D><W><S><V><E><L><Q><E><L><P><E><L><C><F><S><Q><V><I><R><E><G><G><H><A><V><V><W><A><G><Q><L><Q><G><K><L><V><A><I><K><A><F><P><P><R><S><V><A><Q><F><Q><A><E><R><A><L><Y><E><L><P><G><L><Q><H><D><H><I><V><R><F><I><T><A><S><R><G><G><P><G><R><L><L><S><G><P><L><L><V><L><E><L><H><P><K><G><S><L><C><H><Y><L><T><Q><Y><T><S><D><W><G><S><S><L><R><M><A><L><S><L><A><Q><G><L><A><F><L><H><E><E><R><W><Q><N><G><Q><Y><K><P><G><I><A><H><R><D><L><S><S><Q><N><V><L><I><R><E><D><G><S><C><A><I><G><D><L><G><L><A><L><V><L><P><G><L><T><Q><P><P><A><W><T><P><T><Q><P><Q><G><P><A><A><I><M><E><A><G><T><Q><R><Y><M><A><P><E><L><L><D><K><T><L><D><L><Q><D><W><G><M><A><L><R><R><A><D><I><Y><S><L><A><L><L><L><W><E><I><L><S><R><C><P><D><L><R><P><D><S><S><P><P><P><F><Q><L><A><Y><E><A><E><L><G><N><T><P><T><S><D><E><L><W><A><L><A><V><Q><E><R><R><R><P><Y><I><P><S><T><W><R><C><F><A><T><D><P><D><G><L><R><E><L><L><E><D><C><W><D><A><D><P><E><A><R><L><T><A><E><C><V><Q><Q><R><L><A><A><L><A><H><P><Q><E><S><H><P><F><P><E><S><C><P><R><G><C><P><P><L><C><P><E><D><C><T><S><I><P><A><P><T><I><L><P><C><R><P><Q><R><S><A><C><H><F><S><V><Q><Q><G><P><C><S><R><N><P><Q><P><A><C><T><L><S><P><V>
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.<BOP>
Q16671
Q53EU6
GPAT3_HUMAN
MAG-1
Homo
<M><E><G><A><E><L><A><G><K><I><L><S><T><W><L><T><L><V><L><G><F><I><L><L><P><S><V><F><G><V><S><L><G><I><S><E><I><Y><M><K><I><L><V><K><T><L><E><W><A><T><I><R><I><E><K><G><T><P><K><E><S><I><L><K><N><S><A><S><V><G><I><I><Q><R><D><E><S><P><M><E><K><G><L><S><G><L><R><G><R><D><F><E><L><S><D><V><F><Y><F><S><K><K><G><L><E><A><I><V><E><D><E><V><T><Q><R><F><S><S><E><E><L><V><S><W><N><L><L><T><R><T><N><V><N><F><Q><Y><I><S><L><R><L><T><M><V><W><V><L><G><V><I><V><R><Y><C><V><L><L><P><L><R><V><T><L><A><F><I><G><I><S><L><L><V><I><G><T><T><L><V><G><Q><L><P><D><S><S><L><K><N><W><L><S><E><L><V><H><L><T><C><C><R><I><C><V><R><A><L><S><G><T><I><H><Y><H><N><K><Q><Y><R><P><Q><K><G><G><I><C><V><A><N><H><T><S><P><I><D><V><L><I><L><T><T><D><G><C><Y><A><M><V><G><Q><V><H><G><G><L><M><G><I><I><Q><R><A><M><V><K><A><C><P><H><V><W><F><E><R><S><E><M><K><D><R><H><L><V><T><K><R><L><K><E><H><I><A><D><K><K><K><L><P><I><L><I><F><P><E><G><T><C><I><N><N><T><S><V><M><M><F><K><K><G><S><F><E><I><G><G><T><I><H><P><V><A><I><K><Y><N><P><Q><F><G><D><A><F><W><N><S><S><K><Y><N><M><V><S><Y><L><L><R><M><M><T><S><W><A><I><V><C><D><V><W><Y><M><P><P><M><T><R><E><E><G><E><D><A><V><Q><F><A><N><R><V><K><S><A><I><A><I><Q><G><G><L><T><E><L><P><W><D><G><G><L><K><R><A><K><V><K><D><I><F><K><E><E><Q><Q><K><N><Y><S><K><M><I><V><G><N><G><S><L><S>
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone . Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone . Protects cells against lipotoxicity .<BOP>
Q53EU6
P07550
ADRB2_HUMAN
Beta-2 adrenoreceptor
Homo
<M><G><Q><P><G><N><G><S><A><F><L><L><A><P><N><G><S><H><A><P><D><H><D><V><T><Q><E><R><D><E><V><W><V><V><G><M><G><I><V><M><S><L><I><V><L><A><I><V><F><G><N><V><L><V><I><T><A><I><A><K><F><E><R><L><Q><T><V><T><N><Y><F><I><T><S><L><A><C><A><D><L><V><M><G><L><A><V><V><P><F><G><A><A><H><I><L><M><K><M><W><T><F><G><N><F><W><C><E><F><W><T><S><I><D><V><L><C><V><T><A><S><I><E><T><L><C><V><I><A><V><D><R><Y><F><A><I><T><S><P><F><K><Y><Q><S><L><L><T><K><N><K><A><R><V><I><I><L><M><V><W><I><V><S><G><L><T><S><F><L><P><I><Q><M><H><W><Y><R><A><T><H><Q><E><A><I><N><C><Y><A><N><E><T><C><C><D><F><F><T><N><Q><A><Y><A><I><A><S><S><I><V><S><F><Y><V><P><L><V><I><M><V><F><V><Y><S><R><V><F><Q><E><A><K><R><Q><L><Q><K><I><D><K><S><E><G><R><F><H><V><Q><N><L><S><Q><V><E><Q><D><G><R><T><G><H><G><L><R><R><S><S><K><F><C><L><K><E><H><K><A><L><K><T><L><G><I><I><M><G><T><F><T><L><C><W><L><P><F><F><I><V><N><I><V><H><V><I><Q><D><N><L><I><R><K><E><V><Y><I><L><L><N><W><I><G><Y><V><N><S><G><F><N><P><L><I><Y><C><R><S><P><D><F><R><I><A><F><Q><E><L><L><C><L><R><R><S><S><L><K><A><Y><G><N><G><Y><S><S><N><G><N><T><G><E><Q><S><G><Y><H><V><E><Q><E><K><E><N><K><L><L><C><E><D><L><P><G><T><E><D><F><V><G><H><Q><G><T><V><P><S><D><N><I><D><S><Q><G><R><N><C><S><T><N><D><S><L><L>
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.<BOP>
P07550
Q9P0U4
CXXC1_HUMAN
PHD finger and CXXC domain-containing protein 1
Homo
<M><E><G><D><G><S><D><P><E><P><P><D><A><G><E><D><S><K><S><E><N><G><E><N><A><P><I><Y><C><I><C><R><K><P><D><I><N><C><F><M><I><G><C><D><N><C><N><E><W><F><H><G><D><C><I><R><I><T><E><K><M><A><K><A><I><R><E><W><Y><C><R><E><C><R><E><K><D><P><K><L><E><I><R><Y><R><H><K><K><S><R><E><R><D><G><N><E><R><D><S><S><E><P><R><D><E><G><G><G><R><K><R><P><V><P><D><P><D><L><Q><R><R><A><G><S><G><T><G><V><G><A><M><L><A><R><G><S><A><S><P><H><K><S><S><P><Q><P><L><V><A><T><P><S><Q><H><H><Q><Q><Q><Q><Q><Q><I><K><R><S><A><R><M><C><G><E><C><E><A><C><R><R><T><E><D><C><G><H><C><D><F><C><R><D><M><K><K><F><G><G><P><N><K><I><R><Q><K><C><R><L><R><Q><C><Q><L><R><A><R><E><S><Y><K><Y><F><P><S><S><L><S><P><V><T><P><S><E><S><L><P><R><P><R><R><P><L><P><T><Q><Q><Q><P><Q><P><S><Q><K><L><G><R><I><R><E><D><E><G><A><V><A><S><S><T><V><K><E><P><P><E><A><T><A><T><P><E><P><L><S><D><E><D><L><P><L><D><P><D><L><Y><Q><D><F><C><A><G><A><F><D><D><H><G><L><P><W><M><S><D><T><E><E><S><P><F><L><D><P><A><L><R><K><R><A><V><K><V><K><H><V><K><R><R><E><K><K><S><E><K><K><K><E><E><R><Y><K><R><H><R><Q><K><Q><K><H><K><D><K><W><K><H><P><E><R><A><D><A><K><D><P><A><S><L><P><Q><C><L><G><P><G><C><V><R><P><A><Q><P><S><S><K><Y><C><S><D><D><C><G><M><K><L><A><A><N><R><I><Y><E><I><L><P><Q><R><I><Q><Q><W><Q><Q><S><P><C><I><A><E><E><H><G><K><K><L><L><E><R><I><R><R><E><Q><Q><S><A><R><T><R><L><Q><E><M><E><R><R><F><H><E><L><E><A><I><I><L><R><A><K><Q><Q><A><V><R><E><D><E><E><S><N><E><G><D><S><D><D><T><D><L><Q><I><F><C><V><S><C><G><H><P><I><N><P><R><V><A><L><R><H><M><E><R><C><Y><A><K><Y><E><S><Q><T><S><F><G><S><M><Y><P><T><R><I><E><G><A><T><R><L><F><C><D><V><Y><N><P><Q><S><K><T><Y><C><K><R><L><Q><V><L><C><P><E><H><S><R><D><P><K><V><P><A><D><E><V><C><G><C><P><L><V><R><D><V><F><E><L><T><G><D><F><C><R><L><P><K><R><Q><C><N><R><H><Y><C><W><E><K><L><R><R><A><E><V><D><L><E><R><V><R><V><W><Y><K><L><D><E><L><F><E><Q><E><R><N><V><R><T><A><M><T><N><R><A><G><L><L><A><L><M><L><H><Q><T><I><Q><H><D><P><L><T><T><D><L><R><S><S><A><D><R>
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<BOP>
Q9P0U4
P31941
ABC3A_HUMAN
Phorbolin-1
Homo
<M><E><A><S><P><A><S><G><P><R><H><L><M><D><P><H><I><F><T><S><N><F><N><N><G><I><G><R><H><K><T><Y><L><C><Y><E><V><E><R><L><D><N><G><T><S><V><K><M><D><Q><H><R><G><F><L><H><N><Q><A><K><N><L><L><C><G><F><Y><G><R><H><A><E><L><R><F><L><D><L><V><P><S><L><Q><L><D><P><A><Q><I><Y><R><V><T><W><F><I><S><W><S><P><C><F><S><W><G><C><A><G><E><V><R><A><F><L><Q><E><N><T><H><V><R><L><R><I><F><A><A><R><I><Y><D><Y><D><P><L><Y><K><E><A><L><Q><M><L><R><D><A><G><A><Q><V><S><I><M><T><Y><D><E><F><K><H><C><W><D><T><F><V><D><H><Q><G><C><P><F><Q><P><W><D><G><L><D><E><H><S><Q><A><L><S><G><R><L><R><A><I><L><Q><N><Q><G><N>
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.<BOP>
P31941
Q7Z419
R144B_HUMAN
p53-inducible RING finger protein
Homo
<M><G><S><A><G><R><L><H><Y><L><A><M><T><A><E><N><P><T><P><G><D><L><A><P><A><P><L><I><T><C><K><L><C><L><C><E><Q><S><L><D><K><M><T><T><L><Q><E><C><Q><C><I><F><C><T><A><C><L><K><Q><Y><M><Q><L><A><I><R><E><G><C><G><S><P><I><T><C><P><D><M><V><C><L><N><H><G><T><L><Q><E><A><E><I><A><C><L><V><P><V><D><Q><F><Q><L><Y><Q><R><L><K><F><E><R><E><V><H><L><D><P><Y><R><T><W><C><P><V><A><D><C><Q><T><V><C><P><V><A><S><S><D><P><G><Q><P><V><L><V><E><C><P><S><C><H><L><K><F><C><S><C><C><K><D><A><W><H><A><E><V><S><C><R><D><S><Q><P><I><V><L><P><T><E><H><R><A><L><F><G><T><D><A><E><A><P><I><K><Q><C><P><V><C><R><V><Y><I><E><R><N><E><G><C><A><Q><M><M><C><K><N><C><K><H><T><F><C><W><Y><C><L><Q><N><L><D><N><D><I><F><L><R><H><Y><D><K><G><P><C><R><N><K><L><G><H><S><R><A><S><V><M><W><N><R><T><Q><V><V><G><I><L><V><G><L><G><I><I><A><L><V><T><S><P><L><L><L><L><A><S><P><C><I><I><C><C><V><C><K><S><C><R><G><K><K><K><K><H><D><P><S><T><T>
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.<BOP>
Q7Z419
P51617
IRAK1_HUMAN
Interleukin-1 receptor-associated kinase 1
Homo
<M><A><G><G><P><G><P><G><E><P><A><A><P><G><A><Q><H><F><L><Y><E><V><P><P><W><V><M><C><R><F><Y><K><V><M><D><A><L><E><P><A><D><W><C><Q><F><A><A><L><I><V><R><D><Q><T><E><L><R><L><C><E><R><S><G><Q><R><T><A><S><V><L><W><P><W><I><N><R><N><A><R><V><A><D><L><V><H><I><L><T><H><L><Q><L><L><R><A><R><D><I><I><T><A><W><H><P><P><A><P><L><P><S><P><G><T><T><A><P><R><P><S><S><I><P><A><P><A><E><A><E><A><W><S><P><R><K><L><P><S><S><A><S><T><F><L><S><P><A><F><P><G><S><Q><T><H><S><G><P><E><L><G><L><V><P><S><P><A><S><L><W><P><P><P><P><S><P><A><P><S><S><T><K><P><G><P><E><S><S><V><S><L><L><Q><G><A><R><P><F><P><F><C><W><P><L><C><E><I><S><R><G><T><H><N><F><S><E><E><L><K><I><G><E><G><G><F><G><C><V><Y><R><A><V><M><R><N><T><V><Y><A><V><K><R><L><K><E><N><A><D><L><E><W><T><A><V><K><Q><S><F><L><T><E><V><E><Q><L><S><R><F><R><H><P><N><I><V><D><F><A><G><Y><C><A><Q><N><G><F><Y><C><L><V><Y><G><F><L><P><N><G><S><L><E><D><R><L><H><C><Q><T><Q><A><C><P><P><L><S><W><P><Q><R><L><D><I><L><L><G><T><A><R><A><I><Q><F><L><H><Q><D><S><P><S><L><I><H><G><D><I><K><S><S><N><V><L><L><D><E><R><L><T><P><K><L><G><D><F><G><L><A><R><F><S><R><F><A><G><S><S><P><S><Q><S><S><M><V><A><R><T><Q><T><V><R><G><T><L><A><Y><L><P><E><E><Y><I><K><T><G><R><L><A><V><D><T><D><T><F><S><F><G><V><V><V><L><E><T><L><A><G><Q><R><A><V><K><T><H><G><A><R><T><K><Y><L><K><D><L><V><E><E><E><A><E><E><A><G><V><A><L><R><S><T><Q><S><T><L><Q><A><G><L><A><A><D><A><W><A><A><P><I><A><M><Q><I><Y><K><K><H><L><D><P><R><P><G><P><C><P><P><E><L><G><L><G><L><G><Q><L><A><C><C><C><L><H><R><R><A><K><R><R><P><P><M><T><Q><V><Y><E><R><L><E><K><L><Q><A><V><V><A><G><V><P><G><H><S><E><A><A><S><C><I><P><P><S><P><Q><E><N><S><Y><V><S><S><T><G><R><A><H><S><G><A><A><P><W><Q><P><L><A><A><P><S><G><A><S><A><Q><A><A><E><Q><L><Q><R><G><P><N><Q><P><V><E><S><D><E><S><L><G><G><L><S><A><A><L><R><S><W><H><L><T><P><S><C><P><L><D><P><A><P><L><R><E><A><G><C><P><Q><G><D><T><A><G><E><S><S><W><G><S><G><P><G><S><R><P><T><A><V><E><G><L><A><L><G><S><S><A><S><S><S><S><E><P><P><Q><I><I><I><N><P><A><R><Q><K><M><V><Q><K><L><A><L><Y><E><D><G><A><L><D><S><L><Q><L><L><S><S><S><S><L><P><G><L><G><L><E><Q><D><R><Q><G><P><E><E><S><D><E><F><Q><S>
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (
P51617
Q05932
FOLC_HUMAN
Tetrahydrofolylpolyglutamate synthase
Homo
<M><S><R><A><R><S><H><L><R><A><A><L><F><L><A><A><A><S><A><R><G><I><T><T><Q><V><A><A><R><R><G><L><S><A><W><P><V><P><Q><E><P><S><M><E><Y><Q><D><A><V><R><M><L><N><T><L><Q><T><N><A><G><Y><L><E><Q><V><K><R><Q><R><G><D><P><Q><T><Q><L><E><A><M><E><L><Y><L><A><R><S><G><L><Q><V><E><D><L><D><R><L><N><I><I><H><V><T><G><T><K><G><K><G><S><T><C><A><F><T><E><C><I><L><R><S><Y><G><L><K><T><G><F><F><S><S><P><H><L><V><Q><V><R><E><R><I><R><I><N><G><Q><P><I><S><P><E><L><F><T><K><Y><F><W><R><L><Y><H><R><L><E><E><T><K><D><G><S><C><V><S><M><P><P><Y><F><R><F><L><T><L><M><A><F><H><V><F><L><Q><E><K><V><D><L><A><V><V><E><V><G><I><G><G><A><Y><D><C><T><N><I><I><R><K><P><V><V><C><G><V><S><S><L><G><I><D><H><T><S><L><L><G><D><T><V><E><K><I><A><W><Q><K><G><G><I><F><K><Q><G><V><P><A><F><T><V><L><Q><P><E><G><P><L><A><V><L><R><D><R><A><Q><Q><I><S><C><P><L><Y><L><C><P><M><L><E><A><L><E><E><G><G><P><P><L><T><L><G><L><E><G><E><H><Q><R><S><N><A><A><L><A><L><Q><L><A><H><C><W><L><Q><R><Q><D><R><H><G><A><G><E><P><K><A><S><R><P><G><L><L><W><Q><L><P><L><A><P><V><F><Q><P><T><S><H><M><R><L><G><L><R><N><T><E><W><P><G><R><T><Q><V><L><R><R><G><P><L><T><W><Y><L><D><G><A><H><T><A><S><S><A><Q><A><C><V><R><W><F><R><Q><A><L><Q><G><R><E><R><P><S><G><G><P><E><V><R><V><L><L><F><N><A><T><G><D><R><D><P><A><A><L><L><K><L><L><Q><P><C><Q><F><D><Y><A><V><F><C><P><N><L><T><E><V><S><S><T><G><N><A><D><Q><Q><N><F><T><V><T><L><D><Q><V><L><L><R><C><L><E><H><Q><Q><H><W><N><H><L><D><E><E><Q><A><S><P><D><L><W><S><A><P><S><P><E><P><G><G><S><A><S><L><L><L><A><P><H><P><P><H><T><C><S><A><S><S><L><V><F><S><C><I><S><H><A><L><Q><W><I><S><Q><G><R><D><P><I><F><Q><P><P><S><P><P><K><G><L><L><T><H><P><V><A><H><S><G><A><S><I><L><R><E><A><A><A><I><H><V><L><V><T><G><S><L><H><L><V><G><G><V><L><K><L><L><E><P><A><L><S><Q>
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.<BOP>
Q05932
Q9BYQ4
KRA92_HUMAN
Ultrahigh sulfur keratin-associated protein 9.2
Homo
<M><T><H><C><C><S><P><C><C><Q><P><T><C><C><R><T><T><C><C><R><T><T><C><W><K><P><T><T><V><T><T><C><S><S><T><P><C><C><Q><P><A><C><C><V><S><S><C><C><Q><P><C><C><R><P><T><C><C><Q><N><T><C><C><R><T><T><C><C><Q><P><T><C><V><T><S><C><C><Q><P><S><C><C><S><T><P><C><C><Q><P><T><C><C><G><S><S><C><C><G><Q><T><S><C><G><S><S><C><G><Q><S><S><S><C><A><P><V><Y><C><R><R><T><C><Y><Y><P><T><T><V><C><L><P><G><C><L><N><Q><S><C><G><S><N><C><C><Q><P><C><C><R><P><A><C><C><E><T><T><C><C><R><T><T><C><F><Q><P><T><C><V><S><S><C><C><Q><P><S><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BYQ4
Q9NZ63
TLS1_HUMAN
Hepatocellular carcinoma-associated antigen 59
Homo
<M><P><V><V><R><K><I><F><R><R><R><R><G><D><S><E><S><E><E><D><E><Q><D><S><E><E><V><R><L><K><L><E><E><T><R><E><V><Q><N><L><R><K><R><P><N><G><V><S><A><V><A><L><L><V><G><E><K><V><Q><E><E><T><T><L><V><D><D><P><F><Q><M><K><T><G><G><M><V><D><M><K><K><L><K><E><R><G><K><D><K><I><S><E><E><E><D><L><H><L><G><T><S><F><S><A><E><T><N><R><R><D><E><D><A><D><M><M><K><Y><I><E><T><E><L><K><K><R><K><G><I><V><E><H><E><E><Q><K><V><K><P><K><N><A><E><D><C><L><Y><E><L><P><E><N><I><R><V><S><S><A><K><K><T><E><E><M><L><S><N><Q><M><L><S><G><I><P><E><V><D><L><G><I><D><A><K><I><K><N><I><I><S><T><E><D><A><K><A><R><L><L><A><E><Q><Q><N><K><K><K><D><S><E><T><S><F><V><P><T><N><M><A><V><N><Y><V><Q><H><N><R><F><Y><H><E><E><L><N><A><P><I><R><R><N><K><E><E><P><K><A><R><P><L><R><V><G><D><T><E><K><P><E><P><E><R><S><P><P><N><R><K><R><P><A><N><E><K><A><T><D><D><Y><H><Y><E><K><F><K><K><M><N><R><R><Y>
Involved in the regulation of telomeric heterochromatin assembly and control of telomere length.<BOP>
Q9NZ63
P56182
RRP1_HUMAN
RRP1-like protein
Homo
<M><V><S><R><V><Q><L><P><P><E><I><Q><L><A><Q><R><L><A><G><N><E><Q><V><T><R><D><R><A><V><R><K><L><R><K><Y><I><V><A><R><T><Q><R><A><A><G><G><F><T><H><D><E><L><L><K><V><W><K><G><L><F><Y><C><M><W><M><Q><D><K><P><L><L><Q><E><E><L><G><R><T><I><S><Q><L><V><H><A><F><Q><T><T><E><A><Q><H><L><F><L><Q><A><F><W><Q><T><M><N><R><E><W><T><G><I><D><R><L><R><L><D><K><F><Y><M><L><M><R><M><V><L><N><E><S><L><K><V><L><K><M><Q><G><W><E><E><R><Q><I><E><E><L><L><E><L><L><M><T><E><I><L><H><P><S><S><Q><A><P><N><G><V><K><S><H><F><I><E><I><F><L><E><E><L><T><K><V><G><A><E><E><L><T><A><D><Q><N><L><K><F><I><D><P><F><C><R><I><A><A><R><T><K><D><S><L><V><L><N><N><I><T><R><G><I><F><E><T><I><V><E><Q><A><P><L><A><I><E><D><L><L><N><E><L><D><T><Q><D><E><E><V><A><S><D><S><D><E><S><S><E><G><G><E><R><G><D><A><L><S><Q><K><R><S><E><K><P><P><A><G><S><I><C><R><A><E><P><E><A><G><E><E><Q><A><G><D><D><R><D><S><G><G><P><V><L><Q><F><D><Y><E><A><V><A><N><R><L><F><E><M><A><S><R><Q><S><T><P><S><Q><N><R><K><R><L><Y><K><V><I><R><K><L><Q><D><L><A><G><G><I><F><P><E><D><E><I><P><E><K><A><C><R><R><L><L><E><G><R><R><Q><K><K><T><K><K><Q><K><R><L><L><R><L><Q><Q><E><R><G><K><G><E><K><E><P><P><S><P><G><M><E><R><K><R><S><R><R><R><G><V><G><A><D><P><E><A><R><A><E><A><G><E><Q><P><G><T><A><E><R><A><L><L><R><D><Q><P><R><G><R><G><Q><R><G><A><R><Q><R><R><R><T><P><R><P><L><T><S><A><R><A><K><A><A><N><V><Q><E><P><E><K><K><K><K><R><R><E>
Plays a critical role in the generation of 28S rRNA.<BOP>
P56182
Q5RKV6
EXOS6_HUMAN
p11
Homo
<M><P><G><D><H><R><R><I><R><G><P><E><E><S><Q><P><P><Q><L><Y><A><A><D><E><E><E><A><P><G><T><R><D><P><T><R><L><R><P><V><Y><A><R><A><G><L><L><S><Q><A><K><G><S><A><Y><L><E><A><G><G><T><K><V><L><C><A><V><S><G><P><R><Q><A><E><G><G><E><R><G><G><G><P><A><G><A><G><G><E><A><P><A><A><L><R><G><R><L><L><C><D><F><R><R><A><P><F><A><G><R><R><R><R><A><P><P><G><G><C><E><E><R><E><L><A><L><A><L><Q><E><A><L><E><P><A><V><R><L><G><R><Y><P><R><A><Q><L><E><V><S><A><L><L><L><E><D><G><G><S><A><L><A><A><A><L><T><A><A><A><L><A><L><A><D><A><G><V><E><M><Y><D><L><V><V><G><C><G><L><S><L><A><P><G><P><A><P><T><W><L><L><D><P><T><R><L><E><E><E><R><A><A><A><G><L><T><V><A><L><M><P><V><L><N><Q><V><A><G><L><L><G><S><G><E><G><G><L><T><E><S><W><A><E><A><V><R><L><G><L><E><G><C><Q><R><L><Y><P><V><L><Q><Q><S><L><V><R><A><A><R><R><R><G><A><A><A><Q><P>
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex
Q5RKV6
O60762
DPM1_HUMAN
Mannose-P-dolichol synthase subunit 1
Homo
<M><A><S><L><E><V><S><R><S><P><R><R><S><R><R><E><L><E><V><R><S><P><R><Q><N><K><Y><S><V><L><L><P><T><Y><N><E><R><E><N><L><P><L><I><V><W><L><L><V><K><S><F><S><E><S><G><I><N><Y><E><I><I><I><I><D><D><G><S><P><D><G><T><R><D><V><A><E><Q><L><E><K><I><Y><G><S><D><R><I><L><L><R><P><R><E><K><K><L><G><L><G><T><A><Y><I><H><G><M><K><H><A><T><G><N><Y><I><I><I><M><D><A><D><L><S><H><H><P><K><F><I><P><E><F><I><R><K><Q><K><E><G><N><F><D><I><V><S><G><T><R><Y><K><G><N><G><G><V><Y><G><W><D><L><K><R><K><I><I><S><R><G><A><N><F><L><T><Q><I><L><L><R><P><G><A><S><D><L><T><G><S><F><R><L><Y><R><K><E><V><L><E><K><L><I><E><K><C><V><S><K><G><Y><V><F><Q><M><E><M><I><V><R><A><R><Q><L><N><Y><T><I><G><E><V><P><I><S><F><V><D><R><V><Y><G><E><S><K><L><G><G><N><E><I><V><S><F><L><K><G><L><L><T><L><F><A><T><T>
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.<BOP>
O60762
Q8NG81
OR2M7_HUMAN
Olfactory receptor OR1-58
Homo
<M><A><W><E><N><Q><T><F><N><S><D><F><L><L><L><G><I><F><N><H><S><P><T><H><T><F><L><F><F><L><V><L><A><I><F><S><V><A><F><M><G><N><S><I><M><V><L><L><I><Y><L><D><T><Q><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><M><D><L><M><L><I><C><T><T><V><P><K><M><A><F><N><Y><L><S><G><S><K><S><I><S><M><A><G><C><A><T><Q><I><F><F><Y><I><S><L><L><G><S><E><C><F><L><L><A><V><M><S><Y><D><R><Y><T><A><I><C><H><P><L><R><Y><T><N><L><M><R><P><K><I><C><G><L><M><T><A><F><S><W><I><L><G><S><T><D><G><I><I><D><A><V><A><T><F><S><F><S><Y><C><G><S><R><E><I><A><H><F><C><C><D><F><P><S><L><L><I><L><S><C><N><D><T><S><I><F><E><E><V><I><F><I><C><C><I><V><M><L><V><F><P><V><A><I><I><I><T><S><Y><A><R><V><I><L><A><V><I><H><M><G><S><G><E><G><R><R><K><A><F><T><T><C><S><S><H><L><M><V><V><G><M><Y><Y><G><A><G><L><F><M><C><I><Q><P><T><S><H><H><S><P><M><Q><D><K><M><V><S><V><F><Y><T><I><V><T><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><T><R><A><L><M><K><I><L><G><K><G><K><S><G><D>
Odorant receptor.<BOP>
Q8NG81
O95969
SG1D2_HUMAN
Lipophilin-B
Homo
<M><K><L><S><V><C><L><L><L><V><T><L><A><L><C><C><Y><Q><A><N><A><E><F><C><P><A><L><V><S><E><L><L><D><F><F><F><I><S><E><P><L><F><K><L><S><L><A><K><F><D><A><P><P><E><A><V><A><A><K><L><G><V><K><R><C><T><D><Q><M><S><L><Q><K><R><S><L><I><A><E><V><L><V><K><I><L><K><K><C><S><V>
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.<BOP>
O95969
Q8NFQ8
TOIP2_HUMAN
Lumenal domain-like LAP1
Homo
<M><A><D><S><G><L><R><E><P><Q><E><D><S><Q><K><D><L><E><N><D><P><S><V><N><S><Q><A><Q><E><T><T><I><I><A><S><N><A><E><E><A><E><I><L><H><S><A><C><G><L><S><K><D><H><Q><E><V><E><T><E><G><P><E><S><A><D><T><G><D><K><S><E><S><P><D><E><A><N><V><G><K><H><P><K><D><K><T><E><D><E><N><K><Q><S><F><L><D><G><G><K><G><H><H><L><P><S><E><N><L><G><K><E><P><L><D><P><D><P><S><H><S><P><S><D><K><V><G><R><A><D><A><H><L><G><S><S><S><V><A><L><P><K><E><A><S><D><G><T><G><A><S><Q><E><P><P><T><T><D><S><Q><E><A><Q><S><P><G><H><S><S><A><G><Q><E><G><E><D><T><L><R><R><R><L><L><A><P><E><A><G><S><H><P><Q><Q><T><Q><K><L><E><E><I><K><E><N><A><Q><D><T><M><R><Q><I><N><K><K><G><F><W><S><Y><G><P><V><I><L><V><V><L><V><V><A><V><V><A><S><S><V><N><S><Y><Y><S><S><P><A><Q><Q><V><P><K><N><P><A><L><E><A><F><L><A><Q><F><S><Q><L><E><D><K><F><P><G><Q><S><S><F><L><W><Q><R><G><R><K><F><L><Q><K><H><L><N><A><S><N><P><T><E><P><A><T><I><I><F><T><A><A><R><E><G><R><E><T><L><K><C><L><S><H><H><V><A><D><A><Y><T><S><S><Q><K><V><S><P><I><Q><I><D><G><A><G><R><T><W><Q><D><S><D><T><V><K><L><L><V><D><L><E><L><S><Y><G><F><E><N><G><Q><K><A><A><V><V><H><H><F><E><S><F><P><A><G><S><T><L><I><F><Y><K><Y><C><D><H><E><N><A><A><F><K><D><V><A><L><V><L><T><V><L><L><E><E><E><T><L><E><A><S><V><G><P><R><E><T><E><E><K><V><R><D><L><L><W><A><K><F><T><N><S><D><T><P><T><S><F><N><H><M><D><S><D><K><L><S><G><L><W><S><R><I><S><H><L><V><L><P><V><Q><P><V><S><S><I><E><E><Q><G><C><L><F>
Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.<BOP>
Q8NFQ8
Q9NQT6
FSCN3_HUMAN
Testis fascin
Homo
<M><D><E><T><E><W><I><H><R><H><P><K><A><E><D><L><R><V><G><L><I><S><W><A><G><T><Y><L><T><F><E><A><C><K><N><T><V><T><A><T><A><K><S><L><G><R><R><Q><T><W><E><I><L><V><S><N><E><H><E><T><Q><A><V><V><R><L><K><S><V><Q><G><L><Y><L><L><C><E><C><D><G><T><V><C><Y><G><R><P><R><T><S><H><H><G><C><F><L><L><R><F><H><R><N><S><K><W><T><L><Q><C><L><I><S><G><R><Y><L><E><S><N><G><K><D><V><F><C><T><S><H><V><L><S><A><Y><H><M><W><T><P><R><P><A><L><H><V><H><V><I><L><Y><S><P><I><H><R><C><Y><A><R><A><D><P><T><M><G><R><I><W><V><D><A><A><V><P><C><L><E><E><C><G><F><L><L><H><F><R><D><G><C><Y><H><L><E><T><S><T><H><H><F><L><S><H><V><D><R><L><F><S><Q><P><S><S><Q><T><A><F><H><M><Q><V><R><P><G><G><L><V><A><L><C><D><G><E><G><G><M><L><Y><P><Q><G><T><H><L><L><L><G><M><G><C><N><P><M><R><G><E><E><W><F><I><L><Q><H><C><P><T><W><V><S><L><R><S><K><T><G><R><F><I><S><V><I><Y><D><G><E><V><R><A><A><S><E><R><L><N><R><M><S><L><F><Q><F><E><C><D><S><E><S><P><T><V><Q><L><R><S><A><N><G><Y><Y><L><S><Q><R><R><H><R><A><V><M><A><D><G><H><P><L><E><S><D><T><F><F><R><M><H><W><N><C><G><R><I><I><L><Q><S><C><R><G><R><F><L><G><I><A><P><N><S><L><L><M><A><N><V><I><L><P><G><P><N><E><E><F><G><I><L><F><A><N><R><S><F><L><V><L><R><G><R><Y><G><Y><V><G><S><S><S><G><H><D><L><I><Q><C><N><Q><D><Q><P><D><R><I><H><L><L><P><C><R><P><G><I><Y><H><F><Q><A><Q><G><G><S><F><W><S><I><T><S><F><G><T><F><R><P><W><G><K><F><A><L><N><F><C><I><E><L><Q><G><S><N><L><L><T><V><L><A><P><N><G><F><Y><M><R><A><D><Q><S><G><T><L><L><A><D><S><E><D><I><T><R><E><C><I><W><E><F>
Acts as an actin bundling protein.<BOP>
Q9NQT6
P62993
GRB2_HUMAN
SH2/SH3 adapter GRB2
Homo
<M><E><A><I><A><K><Y><D><F><K><A><T><A><D><D><E><L><S><F><K><R><G><D><I><L><K><V><L><N><E><E><C><D><Q><N><W><Y><K><A><E><L><N><G><K><D><G><F><I><P><K><N><Y><I><E><M><K><P><H><P><W><F><F><G><K><I><P><R><A><K><A><E><E><M><L><S><K><Q><R><H><D><G><A><F><L><I><R><E><S><E><S><A><P><G><D><F><S><L><S><V><K><F><G><N><D><V><Q><H><F><K><V><L><R><D><G><A><G><K><Y><F><L><W><V><V><K><F><N><S><L><N><E><L><V><D><Y><H><R><S><T><S><V><S><R><N><Q><Q><I><F><L><R><D><I><E><Q><V><P><Q><Q><P><T><Y><V><Q><A><L><F><D><F><D><P><Q><E><D><G><E><L><G><F><R><R><G><D><F><I><H><V><M><D><N><S><D><P><N><W><W><K><G><A><C><H><G><Q><T><G><M><F><P><R><N><Y><V><T><P><V><N><R><N><V>
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<BOP>
P62993
Q5QJE6
TDIF2_HUMAN
Terminal deoxynucleotidyltransferase-interacting factor 2
Homo
<M><V><V><T><R><S><A><R><A><K><A><S><I><Q><A><A><S><A><E><S><S><G><Q><K><S><F><A><A><N><G><I><Q><A><H><P><E><S><S><T><G><S><D><A><R><T><T><A><E><S><Q><T><T><G><K><Q><S><L><I><P><R><T><P><K><A><R><K><R><K><S><R><T><T><G><S><L><P><K><G><T><E><P><S><T><D><G><E><T><S><E><A><E><S><N><Y><S><V><S><E><H><H><D><T><I><L><R><V><T><R><R><R><Q><I><L><I><A><C><S><P><V><S><S><V><R><K><K><P><K><V><T><P><T><K><E><S><Y><T><E><E><I><V><S><E><A><E><S><H><V><S><G><I><S><R><I><V><L><P><T><E><K><T><T><G><A><R><R><S><K><A><K><S><L><T><D><P><S><Q><E><S><H><T><E><A><I><S><D><A><E><T><S><S><S><D><I><S><F><S><G><I><A><T><R><R><T><R><S><M><Q><R><K><L><K><A><Q><T><E><K><K><D><S><K><I><V><P><G><N><E><K><Q><I><V><G><T><P><V><N><S><E><D><S><D><T><R><Q><T><S><H><L><Q><A><R><S><L><S><E><I><N><K><P><N><F><Y><N><N><D><F><D><D><D><F><S><H><R><S><S><E><N><I><L><T><V><H><E><Q><A><N><V><E><S><L><K><E><T><K><Q><N><C><K><D><L><D><E><D><A><N><G><I><T><D><E><G><K><E><I><N><E><K><S><S><Q><L><K><N><L><S><E><L><Q><D><T><S><L><Q><Q><L><V><S><Q><R><H><S><T><P><Q><N><K><N><A><V><S><V><H><S><N><L><N><S><E><A><V><M><K><S><L><T><Q><T><F><A><T><V><E><V><G><R><W><N><N><N><K><K><S><P><I><K><A><S><D><L><T><K><F><G><D><C><G><G><S><D><D><E><E><E><S><T><V><I><S><V><S><E><D><M><N><S><E><G><N><V><D><F><E><C><D><T><K><L><Y><T><S><A><P><N><T><S><Q><G><K><D><N><S><V><L><L><V><L><S><S><D><E><S><Q><Q><S><E><N><S><E><N><E><E><D><T><L><C><F><V><E><N><S><G><Q><R><E><S><L><S><G><D><T><G><S><L><S><C><D><N><A><L><F><V><I><D><T><T><P><G><M><S><A><D><K><N><F><Y><L><E><E><E><D><K><A><S><E><V><A><I><E><E><E><K><E><E><E><E><D><E><K><S><E><E><D><S><S><D><H><D><E><N><E><D><E><F><S><D><E><E><D><F><L><N><S><T><K><A><K><L><L><K><L><T><S><S><S><I><D><P><G><L><S><I><K><Q><L><G><G><L><Y><I><N><F><N><A><D><K><L><Q><S><N><K><R><T><L><T><Q><I><K><E><K><K><K><N><E><L><L><Q><K><A><V><I><T><P><D><F><E><K><N><H><C><V><P><P><Y><S><E><S><K><Y><Q><L><Q><K><K><R><R><K><E><R><Q><K><T><A><G><D><G><W><F><G><M><K><A><P><E><M><T><N><E><L><K><N><D><L><K><A><L><K><M><R><A><S><M><D><P><K><R><F><Y><K><K><N><D><R><D><G><F><P><K><Y><F><Q><I><G><T><I><V><D><N><P><A><D><F><Y><H><S><R><I><P><K><K><Q><R><K><R><T><I><V><E><E><L><L><A><D><S><E><F><R><R><Y><N><R><R><K><Y><S><E><I><M><A><E><K><A><A><N><A><A><G><K><K><F><R><K><K><K><K><F><R><N>
Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.<BOP>
Q5QJE6
Q92536
YLAT2_HUMAN
y(+)L-type amino acid transporter 2
Homo
<M><E><A><R><E><P><G><R><P><T><P><T><Y><H><L><V><P><N><T><S><Q><S><Q><V><E><E><D><V><S><S><P><P><Q><R><S><S><E><T><M><Q><L><K><K><E><I><S><L><L><N><G><V><S><L><V><V><G><N><M><I><G><S><G><I><F><V><S><P><K><G><V><L><V><H><T><A><S><Y><G><M><S><L><I><V><W><A><I><G><G><L><F><S><V><V><G><A><L><C><Y><A><E><L><G><T><T><I><T><K><S><G><A><S><Y><A><Y><I><L><E><A><F><G><G><F><I><A><F><I><R><L><W><V><S><L><L><V><V><E><P><T><G><Q><A><I><I><A><I><T><F><A><N><Y><I><I><Q><P><S><F><P><S><C><D><P><P><Y><L><A><C><R><L><L><A><A><A><C><I><C><L><L><T><F><V><N><C><A><Y><V><K><W><G><T><R><V><Q><D><T><F><T><Y><A><K><V><V><A><L><I><A><I><I><V><M><G><L><V><K><L><C><Q><G><H><S><E><H><F><Q><D><A><F><E><G><S><S><W><D><M><G><N><L><S><L><A><L><Y><S><A><L><F><S><Y><S><G><W><D><T><L><N><F><V><T><E><E><I><K><N><P><E><R><N><L><P><L><A><I><G><I><S><M><P><I><V><T><L><I><Y><I><L><T><N><V><A><Y><Y><T><V><L><N><I><S><D><V><L><S><S><D><A><V><A><V><T><F><A><D><Q><T><F><G><M><F><S><W><T><I><P><I><A><V><A><L><S><C><F><G><G><L><N><A><S><I><F><A><S><S><R><L><F><F><V><G><S><R><E><G><H><L><P><D><L><L><S><M><I><H><I><E><R><F><T><P><I><P><A><L><L><F><N><C><T><M><A><L><I><Y><L><I><V><E><D><V><F><Q><L><I><N><Y><F><S><F><S><Y><W><F><F><V><G><L><S><V><V><G><Q><L><Y><L><R><W><K><E><P><K><R><P><R><P><L><K><L><S><V><F><F><P><I><V><F><C><I><C><S><V><F><L><V><I><V><P><L><F><T><D><T><I><N><S><L><I><G><I><G><I><A><L><S><G><V><P><F><Y><F><M><G><V><Y><L><P><E><S><R><R><P><L><F><I><R><N><V><L><A><A><I><T><R><G><T><Q><Q><L><C><F><C><V><L><T><E><L><D><V><A><E><E><K><K><D><E><R><K><T><D>
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.<BOP>
Q92536
Q86Y29
BAGE3_HUMAN
Cancer/testis antigen 2.3
Homo
<M><A><A><G><V><V><F><L><A><L><S><A><Q><L><L><Q><A><R><L><M><K><E><E><S><P><V><V><S><W><R><L><E><P><E><D><G><T><A><L><D><V><H><F><V><S><T><L><E><P><L><S><N><A><V><K><R><N><V><P><R><C><I><I><I><L><V><L><Q><E><P><T><P><F><R><I><S><V><T><S><S><C><F><V><Q><N><T><L><T><K><L><L><K><D><R><R><K><M><Q><T><V><Q><C><A><T><A><Q><E><T><S>
Unknown. Candidate gene encoding tumor antigens.<BOP>
Q86Y29
P22001
KCNA3_HUMAN
Voltage-gated potassium channel subunit Kv1.3
Homo
<M><D><E><R><L><S><L><L><R><S><P><P><P><P><S><A><R><H><R><A><H><P><P><Q><R><P><A><S><S><G><G><A><H><T><L><V><N><H><G><Y><A><E><P><A><A><G><R><E><L><P><P><D><M><T><V><V><P><G><D><H><L><L><E><P><E><V><A><D><G><G><G><A><P><P><Q><G><G><C><G><G><G><G><C><D><R><Y><E><P><L><P><P><S><L><P><A><A><G><E><Q><D><C><C><G><E><R><V><V><I><N><I><S><G><L><R><F><E><T><Q><L><K><T><L><C><Q><F><P><E><T><L><L><G><D><P><K><R><R><M><R><Y><F><D><P><L><R><N><E><Y><F><F><D><R><N><R><P><S><F><D><A><I><L><Y><Y><Y><Q><S><G><G><R><I><R><R><P><V><N><V><P><I><D><I><F><S><E><E><I><R><F><Y><Q><L><G><E><E><A><M><E><K><F><R><E><D><E><G><F><L><R><E><E><E><R><P><L><P><R><R><D><F><Q><R><Q><V><W><L><L><F><E><Y><P><E><S><S><G><P><A><R><G><I><A><I><V><S><V><L><V><I><L><I><S><I><V><I><F><C><L><E><T><L><P><E><F><R><D><E><K><D><Y><P><A><S><T><S><Q><D><S><F><E><A><A><G><N><S><T><S><G><S><R><A><G><A><S><S><F><S><D><P><F><F><V><V><E><T><L><C><I><I><W><F><S><F><E><L><L><V><R><F><F><A><C><P><S><K><A><T><F><S><R><N><I><M><N><L><I><D><I><V><A><I><I><P><Y><F><I><T><L><G><T><E><L><A><E><R><Q><G><N><G><Q><Q><A><M><S><L><A><I><L><R><V><I><R><L><V><R><V><F><R><I><F><K><L><S><R><H><S><K><G><L><Q><I><L><G><Q><T><L><K><A><S><M><R><E><L><G><L><L><I><F><F><L><F><I><G><V><I><L><F><S><S><A><V><Y><F><A><E><A><D><D><P><T><S><G><F><S><S><I><P><D><A><F><W><W><A><V><V><T><M><T><T><V><G><Y><G><D><M><H><P><V><T><I><G><G><K><I><V><G><S><L><C><A><I><A><G><V><L><T><I><A><L><P><V><P><V><I><V><S><N><F><N><Y><F><Y><H><R><E><T><E><G><E><E><Q><S><Q><Y><M><H><V><G><S><C><Q><H><L><S><S><S><A><E><E><L><R><K><A><R><S><N><S><T><L><S><K><S><E><Y><M><V><I><E><E><G><G><M><N><H><S><A><F><P><Q><T><P><F><K><T><G><N><S><T><A><T><C><T><T><N><N><N><P><N><S><C><V><N><I><K><K><I><F><T><D><V>
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.<BOP>
P22001
Q9H867
MT21D_HUMAN
Valosin-containing protein lysine methyltransferase
Homo
<M><A><D><T><L><E><S><S><L><E><D><P><L><R><S><F><V><R><V><L><E><K><R><D><G><T><V><L><R><L><Q><Q><Y><S><S><G><G><V><G><C><V><V><W><D><A><A><I><V><L><S><K><Y><L><E><T><P><E><F><S><G><D><G><A><H><A><L><S><R><R><S><V><L><E><L><G><S><G><T><G><A><V><G><L><M><A><A><T><L><G><A><D><V><V><V><T><D><L><E><E><L><Q><D><L><L><K><M><N><I><N><M><N><K><H><L><V><T><G><S><V><Q><A><K><V><L><K><W><G><E><E><I><E><G><F><P><S><P><P><D><F><I><L><M><A><D><C><I><Y><Y><E><E><S><L><E><P><L><L><K><T><L><K><D><I><S><G><F><E><T><C><I><I><C><C><Y><E><Q><R><T><M><G><K><N><P><E><I><E><K><K><Y><F><E><L><L><Q><L><D><F><D><F><E><K><I><P><L><E><K><H><D><E><E><Y><R><S><E><D><I><H><I><I><Y><I><R><K><K><K><S><K><F><P><S>
Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.<BOP>
Q9H867
Q9UGJ0
AAKG2_HUMAN
H91620p
Homo
<M><G><S><A><V><M><D><T><K><K><K><K><D><V><S><S><P><G><G><S><G><G><K><K><N><A><S><Q><K><R><R><S><L><R><V><H><I><P><D><L><S><S><F><A><M><P><L><L><D><G><D><L><E><G><S><G><K><H><S><S><R><K><V><D><S><P><F><G><P><G><S><P><S><K><G><F><F><S><R><G><P><Q><P><R><P><S><S><P><M><S><A><P><V><R><P><K><T><S><P><G><S><P><K><T><V><F><P><F><S><Y><Q><E><S><P><P><R><S><P><R><R><M><S><F><S><G><I><F><R><S><S><S><K><E><S><S><P><N><S><N><P><A><T><S><P><G><G><I><R><F><F><S><R><S><R><K><T><S><G><L><S><S><S><P><S><T><P><T><Q><V><T><K><Q><H><T><F><P><L><E><S><Y><K><H><E><P><E><R><L><E><N><R><I><Y><A><S><S><S><P><P><D><T><G><Q><R><F><C><P><S><S><F><Q><S><P><T><R><P><P><L><A><S><P><T><H><Y><A><P><S><K><A><A><A><L><A><A><A><L><G><P><A><E><A><G><M><L><E><K><L><E><F><E><D><E><A><V><E><D><S><E><S><G><V><Y><M><R><F><M><R><S><H><K><C><Y><D><I><V><P><T><S><S><K><L><V><V><F><D><T><T><L><Q><V><K><K><A><F><F><A><L><V><A><N><G><V><R><A><A><P><L><W><E><S><K><K><Q><S><F><V><G><M><L><T><I><T><D><F><I><N><I><L><H><R><Y><Y><K><S><P><M><V><Q><I><Y><E><L><E><E><H><K><I><E><T><W><R><E><L><Y><L><Q><E><T><F><K><P><L><V><N><I><S><P><D><A><S><L><F><D><A><V><Y><S><L><I><K><N><K><I><H><R><L><P><V><I><D><P><I><S><G><N><A><L><Y><I><L><T><H><K><R><I><L><K><F><L><Q><L><F><M><S><D><M><P><K><P><A><F><M><K><Q><N><L><D><E><L><G><I><G><T><Y><H><N><I><A><F><I><H><P><D><T><P><I><I><K><A><L><N><I><F><V><E><R><R><I><S><A><L><P><V><V><D><E><S><G><K><V><V><D><I><Y><S><K><F><D><V><I><N><L><A><A><E><K><T><Y><N><N><L><D><I><T><V><T><Q><A><L><Q><H><R><S><Q><Y><F><E><G><V><V><K><C><N><K><L><E><I><L><E><T><I><V><D><R><I><V><R><A><E><V><H><R><L><V><V><V><N><E><A><D><S><I><V><G><I><I><S><L><S><D><I><L><Q><A><L><I><L><T><P><A><G><A><K><Q><K><E><T><E><T><E>
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.<BOP>
Q9UGJ0
Q5KU26
COL12_HUMAN
Scavenger receptor with C-type lectin
Homo
<M><K><D><D><F><A><E><E><E><E><V><Q><S><F><G><Y><K><R><F><G><I><Q><E><G><T><Q><C><T><K><C><K><N><N><W><A><L><K><F><S><I><I><L><L><Y><I><L><C><A><L><L><T><I><T><V><A><I><L><G><Y><K><V><V><E><K><M><D><N><V><T><G><G><M><E><T><S><R><Q><T><Y><D><D><K><L><T><A><V><E><S><D><L><K><K><L><G><D><Q><T><G><K><K><A><I><S><T><N><S><E><L><S><T><F><R><S><D><I><L><D><L><R><Q><Q><L><R><E><I><T><E><K><T><S><K><N><K><D><T><L><E><K><L><Q><A><S><G><D><A><L><V><D><R><Q><S><Q><L><K><E><T><L><E><N><N><S><F><L><I><T><T><V><N><K><T><L><Q><A><Y><N><G><Y><V><T><N><L><Q><Q><D><T><S><V><L><Q><G><N><L><Q><N><Q><M><Y><S><H><N><V><V><I><M><N><L><N><N><L><N><L><T><Q><V><Q><Q><R><N><L><I><T><N><L><Q><R><S><V><D><D><T><S><Q><A><I><Q><R><I><K><N><D><F><Q><N><L><Q><Q><V><F><L><Q><A><K><K><D><T><D><W><L><K><E><K><V><Q><S><L><Q><T><L><A><A><N><N><S><A><L><A><K><A><N><N><D><T><L><E><D><M><N><S><Q><L><N><S><F><T><G><Q><M><E><N><I><T><T><I><S><Q><A><N><E><Q><N><L><K><D><L><Q><D><L><H><K><D><A><E><N><R><T><A><I><K><F><N><Q><L><E><E><R><F><Q><L><F><E><T><D><I><V><N><I><I><S><N><I><S><Y><T><A><H><H><L><R><T><L><T><S><N><L><N><E><V><R><T><T><C><T><D><T><L><T><K><H><T><D><D><L><T><S><L><N><N><T><L><A><N><I><R><L><D><S><V><S><L><R><M><Q><Q><D><L><M><R><S><R><L><D><T><E><V><A><N><L><S><V><I><M><E><E><M><K><L><V><D><S><K><H><G><Q><L><I><K><N><F><T><I><L><Q><G><P><P><G><P><R><G><P><R><G><D><R><G><S><Q><G><P><P><G><P><T><G><N><K><G><Q><K><G><E><K><G><E><P><G><P><P><G><P><A><G><E><R><G><P><I><G><P><A><G><P><P><G><E><R><G><G><K><G><S><K><G><S><Q><G><P><K><G><S><R><G><S><P><G><K><P><G><P><Q><G><S><S><G><D><P><G><P><P><G><P><P><G><K><E><G><L><P><G><P><Q><G><P><P><G><F><Q><G><L><Q><G><T><V><G><E><P><G><V><P><G><P><R><G><L><P><G><L><P><G><V><P><G><M><P><G><P><K><G><P><P><G><P><P><G><P><S><G><A><V><V><P><L><A><L><Q><N><E><P><T><P><A><P><E><D><N><G><C><P><P><H><W><K><N><F><T><D><K><C><Y><Y><F><S><V><E><K><E><I><F><E><D><A><K><L><F><C><E><D><K><S><S><H><L><V><F><I><N><T><R><E><E><Q><Q><W><I><K><K><Q><M><V><G><R><E><S><H><W><I><G><L><T><D><S><E><R><E><N><E><W><K><W><L><D><G><T><S><P><D><Y><K><N><W><K><A><G><Q><P><D><N><W><G><H><G><H><G><P><G><E><D><C><A><G><L><I><Y><A><G><Q><W><N><D><F><Q><C><E><D><V><N><N><F><I><C><E><K><D><R><E><T><V><L><S><S><A><L>
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.<BOP>
Q5KU26
Q96A09
TET5B_HUMAN
Non-canonical poly(A) polymerase FAM46B
Homo
<M><M><P><S><E><S><G><A><E><R><R><D><R><A><A><A><Q><V><G><T><A><A><A><T><A><V><A><T><A><A><P><A><G><G><G><P><D><P><E><A><L><S><A><F><P><G><R><H><L><S><G><L><S><W><P><Q><V><K><R><L><D><A><L><L><S><E><P><I><P><I><H><G><R><G><N><F><P><T><L><S><V><Q><P><R><Q><I><V><Q><V><V><R><S><T><L><E><E><Q><G><L><H><V><H><S><V><R><L><H><G><S><A><A><S><H><V><L><H><P><E><S><G><L><G><Y><K><D><L><D><L><V><F><R><V><D><L><R><S><E><A><S><F><Q><L><T><K><A><V><V><L><A><C><L><L><D><F><L><P><A><G><V><S><R><A><K><I><T><P><L><T><L><K><E><A><Y><V><Q><K><L><V><K><V><C><T><D><S><D><R><W><S><L><I><S><L><S><N><K><S><G><K><N><V><E><L><K><F><V><D><S><V><R><R><Q><F><E><F><S><I><D><S><F><Q><I><I><L><D><S><L><L><L><F><G><Q><C><S><S><T><P><M><S><E><A><F><H><P><T><V><T><G><E><S><L><Y><G><D><F><T><E><A><L><E><H><L><R><H><R><V><I><A><T><R><S><P><E><E><I><R><G><G><G><L><L><K><Y><C><H><L><L><V><R><G><F><R><P><R><P><S><T><D><V><R><A><L><Q><R><Y><M><C><S><R><F><F><I><D><F><P><D><L><V><E><Q><R><R><T><L><E><R><Y><L><E><A><H><F><G><G><A><D><A><A><R><R><Y><A><C><L><V><T><L><H><R><V><V><N><E><S><T><V><C><L><M><N><H><E><R><R><Q><T><L><D><L><I><A><A><L><A><L><Q><A><L><A><E><Q><G><P><A><A><T><A><A><L><A><W><R><P><P><G><T><D><G><V><V><P><A><T><V><N><Y><Y><V><T><P><V><Q><P><L><L><A><H><A><Y><P><T><W><L><P><C><N>
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner . May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs . Prefers RNA molecules that are adenosine-rich close to 3'-end . In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 .<BOP>
Q96A09
Q8N6P7
I22R1_HUMAN
ZcytoR11
Homo
<M><R><T><L><L><T><I><L><T><V><G><S><L><A><A><H><A><P><E><D><P><S><D><L><L><Q><H><V><K><F><Q><S><S><N><F><E><N><I><L><T><W><D><S><G><P><E><G><T><P><D><T><V><Y><S><I><E><Y><K><T><Y><G><E><R><D><W><V><A><K><K><G><C><Q><R><I><T><R><K><S><C><N><L><T><V><E><T><G><N><L><T><E><L><Y><Y><A><R><V><T><A><V><S><A><G><G><R><S><A><T><K><M><T><D><R><F><S><S><L><Q><H><T><T><L><K><P><P><D><V><T><C><I><S><K><V><R><S><I><Q><M><I><V><H><P><T><P><T><P><I><R><A><G><D><G><H><R><L><T><L><E><D><I><F><H><D><L><F><Y><H><L><E><L><Q><V><N><R><T><Y><Q><M><H><L><G><G><K><Q><R><E><Y><E><F><F><G><L><T><P><D><T><E><F><L><G><T><I><M><I><C><V><P><T><W><A><K><E><S><A><P><Y><M><C><R><V><K><T><L><P><D><R><T><W><T><Y><S><F><S><G><A><F><L><F><S><M><G><F><L><V><A><V><L><C><Y><L><S><Y><R><Y><V><T><K><P><P><A><P><P><N><S><L><N><V><Q><R><V><L><T><F><Q><P><L><R><F><I><Q><E><H><V><L><I><P><V><F><D><L><S><G><P><S><S><L><A><Q><P><V><Q><Y><S><Q><I><R><V><S><G><P><R><E><P><A><G><A><P><Q><R><H><S><L><S><E><I><T><Y><L><G><Q><P><D><I><S><I><L><Q><P><S><N><V><P><P><P><Q><I><L><S><P><L><S><Y><A><P><N><A><A><P><E><V><G><P><P><S><Y><A><P><Q><V><T><P><E><A><Q><F><P><F><Y><A><P><Q><A><I><S><K><V><Q><P><S><S><Y><A><P><Q><A><T><P><D><S><W><P><P><S><Y><G><V><C><M><E><G><S><G><K><D><S><P><T><G><T><L><S><S><P><K><H><L><R><P><K><G><Q><L><Q><K><E><P><P><A><G><S><C><M><L><G><G><L><S><L><Q><E><V><T><S><L><A><M><E><E><S><Q><E><A><K><S><L><H><Q><P><L><G><I><C><T><D><R><T><S><D><P><N><V><L><H><S><G><E><E><G><T><P><Q><Y><L><K><G><Q><L><P><L><L><S><S><V><Q><I><E><G><H><P><M><S><L><P><L><Q><P><P><S><R><P><C><S><P><S><D><Q><G><P><S><P><W><G><L><L><E><S><L><V><C><P><K><D><E><A><K><S><P><A><P><E><T><S><D><L><E><Q><P><T><E><L><D><S><L><F><R><G><L><A><L><T><V><Q><W><E><S>
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.<BOP>
Q8N6P7
Q9P016
THYN1_HUMAN
Thymocyte protein Thy28
Homo
<M><S><R><P><R><K><R><L><A><G><T><S><G><S><D><K><G><L><S><G><K><R><T><K><T><E><N><S><G><E><A><L><A><K><V><E><D><S><N><P><Q><K><T><S><A><T><K><N><C><L><K><N><L><S><S><H><W><L><M><K><S><E><P><E><S><R><L><E><K><G><V><D><V><K><F><S><I><E><D><L><K><A><Q><P><K><Q><T><T><C><W><D><G><V><R><N><Y><Q><A><R><N><F><L><R><A><M><K><L><G><E><E><A><F><F><Y><H><S><N><C><K><E><P><G><I><A><G><L><M><K><I><V><K><E><A><Y><P><D><H><T><Q><F><E><K><N><N><P><H><Y><D><P><S><S><K><E><D><N><P><K><W><S><M><V><D><V><Q><F><V><R><M><M><K><R><F><I><P><L><A><E><L><K><S><Y><H><Q><A><H><K><A><T><G><G><P><L><K><N><M><V><L><F><T><R><Q><R><L><S><I><Q><P><L><T><Q><E><E><F><D><F><V><L><S><L><E><E><K><E><P><S>
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.<BOP>
Q9P016
O15535
ZSC9_HUMAN
Zinc finger protein 193
Homo
<M><N><T><N><S><K><E><V><L><S><L><G><V><Q><V><P><E><A><W><E><E><L><L><T><M><K><V><E><A><K><S><H><L><Q><W><Q><E><S><R><L><K><R><S><N><P><L><A><R><E><I><F><R><R><H><F><R><Q><L><C><Y><Q><E><T><P><G><P><R><E><A><L><T><R><L><Q><E><L><C><Y><Q><W><L><R><P><H><V><S><T><K><E><Q><I><L><D><L><L><V><L><E><Q><F><L><S><I><L><P><K><E><L><Q><G><W><V><R><E><H><C><P><E><S><G><E><E><A><V><I><L><L><E><D><L><E><R><E><L><D><E><P><Q><H><E><M><V><A><H><R><H><R><Q><E><V><L><C><K><E><M><V><P><L><A><E><Q><T><P><L><T><L><Q><S><Q><P><K><E><P><Q><L><T><C><D><S><A><Q><K><C><H><S><I><G><E><T><D><E><V><T><K><T><E><D><R><E><L><V><L><R><K><D><C><P><K><I><V><E><P><H><G><K><M><F><N><E><Q><T><W><E><V><S><Q><Q><D><P><S><H><G><E><V><G><E><H><K><D><R><I><E><R><Q><W><G><N><L><L><G><E><G><Q><H><K><C><D><E><C><G><K><S><F><T><Q><S><S><G><L><I><R><H><Q><R><I><H><T><G><E><R><P><Y><E><C><N><E><C><G><K><A><F><S><R><S><S><G><L><F><N><H><R><G><I><H><N><I><Q><K><R><Y><H><C><K><E><C><G><K><V><F><S><Q><S><A><G><L><I><Q><H><Q><R><I><H><K><G><E><K><P><Y><Q><C><S><Q><C><S><K><S><Y><S><R><R><S><F><L><I><E><H><Q><R><S><H><T><G><E><R><P><H><Q><C><I><E><C><G><K><S><F><N><R><H><C><N><L><I><R><H><Q><K><I><H><T><V><A><E><L><V>
May be involved in transcriptional regulation.<BOP>
O15535