accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
P49802
RGS7_HUMAN
Regulator of G-protein signaling 7
Homo
<M><A><Q><G><N><N><Y><G><Q><T><S><N><G><V><A><D><E><S><P><N><M><L><V><Y><R><K><M><E><D><V><I><A><R><M><Q><D><E><K><N><G><I><P><I><R><T><V><K><S><F><L><S><K><I><P><S><V><F><S><G><S><D><I><V><Q><W><L><I><K><N><L><T><I><E><D><P><V><E><A><L><H><L><G><T><L><M><A><A><H><G><Y><F><F><P><I><S><D><H><V><L><T><L><K><D><D><G><T><F><Y><R><F><Q><T><P><Y><F><W><P><S><N><C><W><E><P><E><N><T><D><Y><A><V><Y><L><C><K><R><T><M><Q><N><K><A><R><L><E><L><A><D><Y><E><A><E><S><L><A><R><L><Q><R><A><F><A><R><K><W><E><F><I><F><M><Q><A><E><A><Q><A><K><V><D><K><K><R><D><K><I><E><R><K><I><L><D><S><Q><E><R><A><F><W><D><V><H><R><P><V><P><G><C><V><N><T><T><E><V><D><I><K><K><S><S><R><M><R><N><P><H><K><T><R><K><S><V><Y><G><L><Q><N><D><I><R><S><H><S><P><T><H><T><P><T><P><E><T><K><P><P><T><E><D><E><L><Q><Q><Q><I><K><Y><W><Q><I><Q><L><D><R><H><R><L><K><M><S><K><V><A><D><S><L><L><S><Y><T><E><Q><Y><L><E><Y><D><P><F><L><L><P><P><D><P><S><N><P><W><L><S><D><D><T><T><F><W><E><L><E><A><S><K><E><P><S><Q><Q><R><V><K><R><W><G><F><G><M><D><E><A><L><K><D><P><V><G><R><E><Q><F><L><K><F><L><E><S><E><F><S><S><E><N><L><R><F><W><L><A><V><E><D><L><K><K><R><P><I><K><E><V><P><S><R><V><Q><E><I><W><Q><E><F><L><A><P><G><A><P><S><A><I><N><L><D><S><K><S><Y><D><K><T><T><Q><N><V><K><E><P><G><R><Y><T><F><E><D><A><Q><E><H><I><Y><K><L><M><K><S><D><S><Y><P><R><F><I><R><S><S><A><Y><Q><E><L><L><Q><A><K><K><K><S><G><N><S><M><D><R><R><T><S><F><E><K><F><A><Q><N><V><G><R><N><I><P><I><F><P><C><H><K><N><C><T><P><T><L><R><A><S><T><N><L><L>
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . The RGS7/GNB5 dimer enhances GNAO1 GTPase activity . May play a role in synaptic vesicle exocytosis . Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling .<BOP>
P49802
O94830
DDHD2_HUMAN
SAM, WWE and DDHD domain-containing protein 1
Homo
<M><S><S><V><Q><S><Q><Q><E><Q><L><S><Q><S><D><P><S><P><S><P><N><S><C><S><S><F><E><L><I><D><M><D><A><G><S><L><Y><E><P><V><S><P><H><W><F><Y><C><K><I><I><D><S><K><E><T><W><I><P><F><N><S><E><D><S><Q><Q><L><E><E><A><Y><S><S><G><K><G><C><N><G><R><V><V><P><T><D><G><G><R><Y><D><V><H><L><G><E><R><M><R><Y><A><V><Y><W><D><E><L><A><S><E><V><R><R><C><T><W><F><Y><K><G><D><K><D><N><K><Y><V><P><Y><S><E><S><F><S><Q><V><L><E><E><T><Y><M><L><A><V><T><L><D><E><W><K><K><K><L><E><S><P><N><R><E><I><I><I><L><H><N><P><K><L><M><V><H><Y><Q><P><V><A><G><S><D><D><W><G><S><T><P><T><E><Q><G><R><P><R><T><V><K><R><G><V><E><N><I><S><V><D><I><H><C><G><E><P><L><Q><I><D><H><L><V><F><V><V><H><G><I><G><P><A><C><D><L><R><F><R><S><I><V><Q><C><V><N><D><F><R><S><V><S><L><N><L><L><Q><T><H><F><K><K><A><Q><E><N><Q><Q><I><G><R><V><E><F><L><P><V><N><W><H><S><P><L><H><S><T><G><V><D><V><D><L><Q><R><I><T><L><P><S><I><N><R><L><R><H><F><T><N><D><T><I><L><D><V><F><F><Y><N><S><P><T><Y><C><Q><T><I><V><D><T><V><A><S><E><M><N><R><I><Y><T><L><F><L><Q><R><N><P><D><F><K><G><G><V><S><I><A><G><H><S><L><G><S><L><I><L><F><D><I><L><T><N><Q><K><D><S><L><G><D><I><D><S><E><K><D><S><L><N><I><V><M><D><Q><G><D><T><P><T><L><E><E><D><L><K><K><L><Q><L><S><E><F><F><D><I><F><E><K><E><K><V><D><K><E><A><L><A><L><C><T><D><R><D><L><Q><E><I><G><I><P><L><G><P><R><K><K><I><L><N><Y><F><S><T><R><K><N><S><M><G><I><K><R><P><A><P><Q><P><A><S><G><A><N><I><P><K><E><S><E><F><C><S><S><S><N><T><R><N><G><D><Y><L><D><V><G><I><G><Q><V><S><V><K><Y><P><R><L><I><Y><K><P><E><I><F><F><A><F><G><S><P><I><G><M><F><L><T><V><R><G><L><K><R><I><D><P><N><Y><R><F><P><T><C><K><G><F><F><N><I><Y><H><P><F><D><P><V><A><Y><R><I><E><P><M><V><V><P><G><V><E><F><E><P><M><L><I><P><H><H><K><G><R><K><R><M><H><L><E><L><R><E><G><L><T><R><M><S><M><D><L><K><N><N><L><L><G><S><L><R><M><A><W><K><S><F><T><R><A><P><Y><P><A><L><Q><A><S><E><T><P><E><E><T><E><A><E><P><E><S><T><S><E><K><P><S><D><V><N><T><E><E><T><S><V><A><V><K><E><E><V><L><P><I><N><V><G><M><L><N><G><G><Q><R><I><D><Y><V><L><Q><E><K><P><I><E><S><F><N><E><Y><L><F><A><L><Q><S><H><L><C><Y><W><E><S><E><D><T><V><L><L><V><L><K><E><I><Y><Q><T><Q><G><I><F><L><D><Q><P><L><Q>
Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.<BOP>
O94830
Q8NB59
SYT14_HUMAN
Synaptotagmin XIV
Homo
<M><A><I><E><G><G><E><R><T><C><G><V><H><E><L><I><C><I><R><K><V><S><P><E><A><V><G><F><L><S><A><V><G><V><F><I><I><L><M><L><L><L><F><L><Y><I><N><K><K><F><C><F><E><N><V><G><G><F><P><D><L><G><S><E><Y><S><T><R><K><N><S><Q><D><K><I><Y><N><S><Y><M><D><K><D><E><H><G><S><S><S><E><S><E><D><E><A><L><G><K><Y><H><E><A><L><S><R><T><H><N><S><R><L><P><L><A><D><S><R><Q><R><N><Y><A><W><E><T><R><Q><K><Y><S><P><L><S><A><E><Y><D><G><Y><S><S><E><A><S><I><D><E><G><N><C><I><Q><R><M><R><R><T><P><P><L><D><E><L><Q><P><P><P><Y><Q><D><D><S><G><S><P><H><L><S><C><T><P><S><E><I><G><D><S><K><C><E><F><S><H><C><S><N><S><P><R><C><S><Y><N><K><C><P><S><E><G><S><T><G><H><E><I><E><S><F><H><N><K><G><Y><E><E><D><V><P><S><D><S><T><A><V><L><S><P><E><D><M><S><A><Q><G><S><S><S><Q><L><P><K><P><F><D><P><E><P><E><A><K><Y><G><T><L><D><V><T><F><D><Y><D><S><Q><E><Q><K><L><L><V><T><V><T><A><V><T><D><I><P><T><Y><N><R><T><G><G><N><S><W><Q><V><H><L><V><L><L><P><I><K><K><Q><R><A><K><T><S><I><Q><R><G><P><C><P><V><F><T><E><T><F><K><F><N><H><V><E><S><E><M><I><G><N><Y><A><V><R><F><R><L><Y><G><V><H><R><M><K><K><E><K><I><V><G><E><K><I><F><Y><L><T><K><L><N><L><Q><G><K><M><S><L><P><V><I><L><E><P><S><Y><N><H><S><G><C><D><S><Q><M><S><V><S><E><M><S><C><S><E><S><T><S><S><C><Q><S><L><E><H><G><S><V><P><E><I><L><I><G><L><L><Y><N><A><T><T><G><R><L><S><A><E><V><I><K><G><S><H><F><K><N><L><A><A><N><R><P><P><N><T><Y><V><K><L><T><L><L><N><S><M><G><Q><E><M><S><K><C><K><T><S><I><R><R><G><Q><P><N><P><V><Y><K><E><T><F><V><F><Q><V><A><L><F><Q><L><S><D><V><T><L><I><L><S><V><Y><N><K><R><S><M><K><R><K><E><M><I><G><W><I><S><L><G><L><N><S><S><G><E><E><E><L><N><H><W><T><E><M><K><E><S><K><G><Q><Q><V><C><R><W><H><A><L><L><E><S>
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.<BOP>
Q8NB59
Q3ZCX4
ZN568_HUMAN
Zinc finger protein 568
Homo
<M><T><S><Q><S><S><V><I><S><N><S><C><V><T><M><E><R><L><S><H><M><M><E><R><K><A><W><C><S><Q><E><S><A><L><S><E><E><E><E><D><T><T><R><P><L><E><T><V><T><F><K><D><V><A><V><D><L><T><Q><E><E><W><E><Q><M><K><P><A><Q><R><N><L><Y><R><D><V><M><L><E><N><Y><S><N><L><V><T><V><G><C><Q><V><T><K><P><D><V><I><F><K><L><E><Q><E><E><E><P><W><V><M><E><E><E><M><F><G><R><H><C><P><E><V><W><E><V><D><E><Q><I><K><K><Q><Q><E><T><L><V><R><K><V><T><S><I><S><K><K><I><L><I><K><E><K><V><I><E><C><K><K><V><A><K><I><F><P><L><S><S><D><I><V><T><S><R><Q><S><F><Y><D><C><D><S><L><D><K><G><L><E><H><N><L><D><L><L><R><Y><E><K><G><C><V><R><E><K><Q><S><N><E><F><G><K><P><F><Y><H><C><A><S><Y><V><V><T><P><F><K><C><N><Q><C><G><Q><D><F><S><H><K><F><D><L><I><R><H><E><R><I><H><A><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><R><K><E><N><L><I><T><H><Q><K><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><I><Q><M><S><N><L><I><R><H><H><R><I><H><T><G><E><K><P><Y><A><C><K><D><C><W><K><A><F><S><Q><K><S><N><L><I><E><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><S><F><S><Q><K><Q><N><L><I><E><H><E><K><I><H><T><G><E><K><P><Y><A><C><N><E><C><G><R><A><F><S><R><M><S><S><V><T><L><H><M><R><S><H><T><G><E><K><P><Y><K><C><N><K><C><G><K><A><F><S><Q><C><S><V><F><I><I><H><M><R><S><H><T><G><E><K><P><Y><V><C><S><E><C><G><K><A><F><S><Q><S><S><S><L><T><V><H><M><R><N><H><T><A><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><R><K><E><N><L><I><T><H><Q><K><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><I><Q><M><S><N><L><I><R><H><Q><R><I><H><T><G><E><K><P><Y><A><C><T><V><C><G><K><A><F><S><Q><K><S><N><L><T><E><H><E><K><I><H><T><G><E><K><P><Y><H><C><N><Q><C><G><K><A><F><S><Q><R><Q><N><L><L><E><H><E><K><I><H><T><G><E><K><P><F><K><C><N><E><C><G><K><A><F><S><R><I><S><S><L><T><L><H><V><R><S><H><T><G><E><K><P><Y><E><C><N><K><C><G><K><A><F><S><Q><C><S><L><L><I><I><H><M><R><S><H><T><G><E><K><P><F><E><C><N><E><C><G><K><A><F><S><Q><R><A><S><L><S><I><H><K><R><G><H><T><G><E><R><H><Q><V><Y>
Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.<BOP>
Q3ZCX4
Q8N6F7
GCSAM_HUMAN
Germinal center-associated lymphoma protein
Homo
<M><G><N><S><L><L><R><E><N><R><R><Q><Q><N><T><Q><E><M><P><W><N><V><R><M><Q><S><P><K><Q><R><T><S><R><C><W><D><H><H><I><A><E><G><C><F><C><L><P><W><K><K><I><L><I><F><E><K><R><Q><D><S><Q><N><E><N><E><R><M><S><S><T><P><I><Q><D><N><V><D><Q><T><Y><S><E><E><L><C><Y><T><L><I><N><H><R><V><L><C><T><R><P><S><G><N><S><A><E><E><Y><Y><E><N><V><P><C><K><A><E><R><P><R><E><S><L><G><G><T><E><T><E><Y><S><L><L><H><M><P><S><T><D><P><R><H><A><R><S><P><E><D><E><Y><E><L><L><M><P><H><R><I><S><S><H><F><L><Q><Q><P><R><P><L><M><A><P><S><E><T><Q><F><S><H><L>
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.<BOP>
Q8N6F7
A6NHX0
CAST2_HUMAN
GATS-like protein 2
Homo
<M><E><L><H><I><L><E><H><R><L><Q><V><A><S><V><A><K><E><S><I><P><L><F><T><Y><G><L><I><K><L><A><F><L><S><S><K><T><R><C><K><F><F><S><L><T><E><T><P><E><D><Y><T><I><I><V><D><E><E><G><F><L><E><L><P><S><S><E><H><L><S><V><A><D><A><T><W><L><A><L><N><V><V><S><G><G><G><S><F><S><S><S><Q><P><I><G><V><T><K><I><A><K><S><V><I><A><P><L><A><D><Q><N><I><S><V><F><M><L><S><T><Y><Q><T><D><F><I><L><V><R><E><R><D><L><P><F><V><T><H><T><L><S><S><E><F><T><I><L><R><V><V><N><G><E><T><V><A><A><E><N><L><G><I><T><N><G><F><V><K><P><K><L><V><Q><R><P><V><I><H><P><L><S><S><P><S><N><R><F><C><V><T><S><L><D><P><D><T><L><P><A><V><A><T><L><L><M><D><V><M><F><Y><S><N><G><V><K><D><P><M><A><T><G><D><D><C><G><H><I><R><F><F><S><F><S><L><I><E><G><Y><I><S><L><V><M><D><V><Q><T><Q><Q><R><F><P><S><N><L><L><F><T><S><A><S><G><E><L><W><K><M><V><R><I><G><G><Q><P><L><G><F><D><E><C><G><I><V><A><Q><I><S><E><P><L><A><A><A><D><I><P><A><Y><Y><I><S><T><F><K><F><D><H><A><L><V><P><E><E><N><I><N><G><V><I><S><A><L><K><V><S><Q><A><E><K><H>
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.<BOP>
A6NHX0
Q9NZS2
KLRF1_HUMAN
C-type lectin domain family 5 member C
Homo
<M><Q><D><E><E><R><Y><M><T><L><N><V><Q><S><K><K><R><S><S><A><Q><T><S><Q><L><T><F><K><D><Y><S><V><T><L><H><W><Y><K><I><L><L><G><I><S><G><T><V><N><G><I><L><T><L><T><L><I><S><L><I><L><L><V><S><Q><G><V><L><L><K><C><Q><K><G><S><C><S><N><A><T><Q><Y><E><D><T><G><D><L><K><V><N><N><G><T><R><R><N><I><S><N><K><D><L><C><A><S><R><S><A><D><Q><T><V><L><C><Q><S><E><W><L><K><Y><Q><G><K><C><Y><W><F><S><N><E><M><K><S><W><S><D><S><Y><V><Y><C><L><E><R><K><S><H><L><L><I><I><H><D><Q><L><E><M><A><F><I><Q><K><N><L><R><Q><L><N><Y><V><W><I><G><L><N><F><T><S><L><K><M><T><W><T><W><V><D><G><S><P><I><D><S><K><I><F><F><I><K><G><P><A><K><E><N><S><C><A><A><I><K><E><S><K><I><F><S><E><T><C><S><S><V><F><K><W><I><C><Q><Y>
Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.<BOP>
Q9NZS2
Q8N8C0
ZN781_HUMAN
Zinc finger protein 781
Homo
<M><Q><R><N><A><M><Y><L><K><N><V><A><E><T><A><C><N><F><Q><L><T><Q><Y><Q><I><S><H><A><N><Q><K><P><Y><E><C><Q><I><C><G><K><P><F><R><K><R><A><H><L><T><Q><H><N><R><I><H><T><G><G><K><P><Y><E><C><K><E><C><G><K><V><F><I><C><C><S><T><L><I><Q><H><K><R><T><H><T><S><E><K><P><Y><E><C><L><E><C><R><K><T><F><R><R><S><A><H><L><I><R><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><Q><C><W><K><A><F><A><S><V><S><D><L><I><D><I><G><K><F><T><L><M><R><D><F><T><N><V><Q><N><V><G><R><H><L><T><I><A><Q><L><L><F><S><I><R><E><F><T><L><V><R><S><P><L><N><V><R><N><V><A><K><H><S><I><I><A><Q><H><L><L><N><T><R><E><L><I><L><M><R><N><L><M><N><V><R><N><V><K><R><L><L><G><K><V><H><I><L><L><N><I><K><E><F><I><L><V><R><N><H><M><S><V><S><N><V><G><R><L><S><L><V><F><L><I><L><I><D><I><R><E><F><T><L><V><K><N><P><M><N><V><K><N><V><V><E><L><L><T><I><V><Q><L><L><F><N><T><R><E><F><T><L><V><R><R><L><M><N><I><S><S><V><G><R><F><L><S><P><V><Q><H><L><F><N><I><R><E><H><I><L><M><K><N><L><M><N><V><S><N><A><R><R><P><S><S><I><M><H><I><L><F><D><I><K><E><F><I><L><V><R><N><L><I><N><V><S><N><V><G><R><P><L><L><L><F><L><I>
May be involved in transcriptional regulation.<BOP>
Q8N8C0
P36578
RL4_HUMAN
Large ribosomal subunit protein uL4
Homo
<M><A><C><A><R><P><L><I><S><V><Y><S><E><K><G><E><S><S><G><K><N><V><T><L><P><A><V><F><K><A><P><I><R><P><D><I><V><N><F><V><H><T><N><L><R><K><N><N><R><Q><P><Y><A><V><S><E><L><A><G><H><Q><T><S><A><E><S><W><G><T><G><R><A><V><A><R><I><P><R><V><R><G><G><G><T><H><R><S><G><Q><G><A><F><G><N><M><C><R><G><G><R><M><F><A><P><T><K><T><W><R><R><W><H><R><R><V><N><T><T><Q><K><R><Y><A><I><C><S><A><L><A><A><S><A><L><P><A><L><V><M><S><K><G><H><R><I><E><E><V><P><E><L><P><L><V><V><E><D><K><V><E><G><Y><K><K><T><K><E><A><V><L><L><L><K><K><L><K><A><W><N><D><I><K><K><V><Y><A><S><Q><R><M><R><A><G><K><G><K><M><R><N><R><R><R><I><Q><R><R><G><P><C><I><I><Y><N><E><D><N><G><I><I><K><A><F><R><N><I><P><G><I><T><L><L><N><V><S><K><L><N><I><L><K><L><A><P><G><G><H><V><G><R><F><C><I><W><T><E><S><A><F><R><K><L><D><E><L><Y><G><T><W><R><K><A><A><S><L><K><S><N><Y><N><L><P><M><H><K><M><I><N><T><D><L><S><R><I><L><K><S><P><E><I><Q><R><A><L><R><A><P><R><K><K><I><H><R><R><V><L><K><K><N><P><L><K><N><L><R><I><M><L><K><L><N><P><Y><A><K><T><M><R><R><N><T><I><L><R><Q><A><R><N><H><K><L><R><V><D><K><A><A><A><A><A><A><A><L><Q><A><K><S><D><E><K><A><A><V><A><G><K><K><P><V><V><G><K><K><G><K><K><A><A><V><G><V><K><K><Q><K><K><P><L><V><G><K><K><A><A><A><T><K><K><P><A><P><E><K><K><P><A><E><K><K><P><T><T><E><E><K><K><P><A><A>
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.<BOP>
P36578
Q9Y5J5
PHLA3_HUMAN
TDAG51/Ipl homolog 1
Homo
<M><T><A><A><A><T><A><T><V><L><K><E><G><V><L><E><K><R><S><G><G><L><L><Q><L><W><K><R><K><R><C><V><L><T><E><R><G><L><Q><L><F><E><A><K><G><T><G><G><R><P><K><E><L><S><F><A><R><I><K><A><V><E><C><V><E><S><T><G><R><H><I><Y><F><T><L><V><T><E><G><G><G><E><I><D><F><R><C><P><L><E><D><P><G><W><N><A><Q><I><T><L><G><L><V><K><F><K><N><Q><Q><A><I><Q><T><V><R><A><R><Q><S><L><G><T><G><T><L><V><S>
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.<BOP>
Q9Y5J5
P25774
CATS_HUMAN
Cathepsin S
Homo
<M><K><R><L><V><C><V><L><L><V><C><S><S><A><V><A><Q><L><H><K><D><P><T><L><D><H><H><W><H><L><W><K><K><T><Y><G><K><Q><Y><K><E><K><N><E><E><A><V><R><R><L><I><W><E><K><N><L><K><F><V><M><L><H><N><L><E><H><S><M><G><M><H><S><Y><D><L><G><M><N><H><L><G><D><M><T><S><E><E><V><M><S><L><M><S><S><L><R><V><P><S><Q><W><Q><R><N><I><T><Y><K><S><N><P><N><R><I><L><P><D><S><V><D><W><R><E><K><G><C><V><T><E><V><K><Y><Q><G><S><C><G><A><C><W><A><F><S><A><V><G><A><L><E><A><Q><L><K><L><K><T><G><K><L><V><S><L><S><A><Q><N><L><V><D><C><S><T><E><K><Y><G><N><K><G><C><N><G><G><F><M><T><T><A><F><Q><Y><I><I><D><N><K><G><I><D><S><D><A><S><Y><P><Y><K><A><M><D><Q><K><C><Q><Y><D><S><K><Y><R><A><A><T><C><S><K><Y><T><E><L><P><Y><G><R><E><D><V><L><K><E><A><V><A><N><K><G><P><V><S><V><G><V><D><A><R><H><P><S><F><F><L><Y><R><S><G><V><Y><Y><E><P><S><C><T><Q><N><V><N><H><G><V><L><V><V><G><Y><G><D><L><N><G><K><E><Y><W><L><V><K><N><S><W><G><H><N><F><G><E><E><G><Y><I><R><M><A><R><N><K><G><N><H><C><G><I><A><S><F><P><S><Y><P><E><I>
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation . The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.<BOP>
P25774
Q04609
FOLH1_HUMAN
Pteroylpoly-gamma-glutamate carboxypeptidase
Homo
<M><W><N><L><L><H><E><T><D><S><A><V><A><T><A><R><R><P><R><W><L><C><A><G><A><L><V><L><A><G><G><F><F><L><L><G><F><L><F><G><W><F><I><K><S><S><N><E><A><T><N><I><T><P><K><H><N><M><K><A><F><L><D><E><L><K><A><E><N><I><K><K><F><L><Y><N><F><T><Q><I><P><H><L><A><G><T><E><Q><N><F><Q><L><A><K><Q><I><Q><S><Q><W><K><E><F><G><L><D><S><V><E><L><A><H><Y><D><V><L><L><S><Y><P><N><K><T><H><P><N><Y><I><S><I><I><N><E><D><G><N><E><I><F><N><T><S><L><F><E><P><P><P><P><G><Y><E><N><V><S><D><I><V><P><P><F><S><A><F><S><P><Q><G><M><P><E><G><D><L><V><Y><V><N><Y><A><R><T><E><D><F><F><K><L><E><R><D><M><K><I><N><C><S><G><K><I><V><I><A><R><Y><G><K><V><F><R><G><N><K><V><K><N><A><Q><L><A><G><A><K><G><V><I><L><Y><S><D><P><A><D><Y><F><A><P><G><V><K><S><Y><P><D><G><W><N><L><P><G><G><G><V><Q><R><G><N><I><L><N><L><N><G><A><G><D><P><L><T><P><G><Y><P><A><N><E><Y><A><Y><R><R><G><I><A><E><A><V><G><L><P><S><I><P><V><H><P><I><G><Y><Y><D><A><Q><K><L><L><E><K><M><G><G><S><A><P><P><D><S><S><W><R><G><S><L><K><V><P><Y><N><V><G><P><G><F><T><G><N><F><S><T><Q><K><V><K><M><H><I><H><S><T><N><E><V><T><R><I><Y><N><V><I><G><T><L><R><G><A><V><E><P><D><R><Y><V><I><L><G><G><H><R><D><S><W><V><F><G><G><I><D><P><Q><S><G><A><A><V><V><H><E><I><V><R><S><F><G><T><L><K><K><E><G><W><R><P><R><R><T><I><L><F><A><S><W><D><A><E><E><F><G><L><L><G><S><T><E><W><A><E><E><N><S><R><L><L><Q><E><R><G><V><A><Y><I><N><A><D><S><S><I><E><G><N><Y><T><L><R><V><D><C><T><P><L><M><Y><S><L><V><H><N><L><T><K><E><L><K><S><P><D><E><G><F><E><G><K><S><L><Y><E><S><W><T><K><K><S><P><S><P><E><F><S><G><M><P><R><I><S><K><L><G><S><G><N><D><F><E><V><F><F><Q><R><L><G><I><A><S><G><R><A><R><Y><T><K><N><W><E><T><N><K><F><S><G><Y><P><L><Y><H><S><V><Y><E><T><Y><E><L><V><E><K><F><Y><D><P><M><F><K><Y><H><L><T><V><A><Q><V><R><G><G><M><V><F><E><L><A><N><S><I><V><L><P><F><D><C><R><D><Y><A><V><V><L><R><K><Y><A><D><K><I><Y><S><I><S><M><K><H><P><Q><E><M><K><T><Y><S><V><S><F><D><S><L><F><S><A><V><K><N><F><T><E><I><A><S><K><F><S><E><R><L><Q><D><F><D><K><S><N><P><I><V><L><R><M><M><N><D><Q><L><M><F><L><E><R><A><F><I><D><P><L><G><L><P><D><R><P><F><Y><R><H><V><I><Y><A><P><S><S><H><N><K><Y><A><G><E><S><F><P><G><I><Y><D><A><L><F><D><I><E><S><K><V><D><P><S><K><A><W><G><E><V><K><R><Q><I><Y><V><A><A><F><T><V><Q><A><A><A><E><T><L><S><E><V><A>
Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.<BOP>
Q04609
O15079
SNPH_HUMAN
Syntaphilin
Homo
<M><A><M><S><L><P><G><S><R><R><T><S><A><G><S><R><R><R><T><S><P><P><V><S><V><R><D><A><Y><G><T><S><S><L><S><S><S><S><N><S><G><S><Y><K><G><S><D><S><S><P><T><P><R><R><S><M><K><Y><T><L><C><S><D><N><H><G><I><K><P><P><T><P><E><Q><Y><L><T><P><L><Q><Q><K><E><V><C><I><R><H><L><K><A><R><L><K><D><T><Q><D><R><L><Q><D><R><D><T><E><I><D><D><L><K><T><Q><L><S><R><M><Q><E><D><W><I><E><E><E><C><H><R><V><E><A><Q><L><A><L><K><E><A><R><K><E><I><K><Q><L><K><Q><V><I><D><T><V><K><N><N><L><I><D><K><D><K><G><L><Q><K><Y><F><V><D><I><N><I><Q><N><K><K><L><E><T><L><L><H><S><M><E><V><A><Q><N><G><M><A><K><E><D><G><T><G><E><S><A><G><G><S><P><A><R><S><L><T><R><S><S><T><Y><T><K><L><S><D><P><A><V><C><G><D><R><Q><P><G><D><P><S><S><G><S><A><E><D><G><A><D><S><G><F><A><A><A><D><D><T><L><S><R><T><D><A><L><E><A><S><S><L><L><S><S><G><V><D><C><G><T><E><E><T><S><L><H><S><S><F><G><L><G><P><R><F><P><A><S><N><T><Y><E><K><L><L><C><G><M><E><A><G><V><Q><A><S><C><M><Q><E><R><A><I><Q><T><D><F><V><Q><Y><Q><P><D><L><D><T><I><L><E><K><V><T><Q><A><Q><V><C><G><T><D><P><E><S><G><D><R><C><P><E><L><D><A><H><P><S><G><P><R><D><P><N><S><A><V><V><V><T><V><G><D><E><L><E><A><P><E><P><I><T><R><G><P><T><P><Q><R><P><G><A><N><P><N><P><G><Q><S><V><S><V><V><C><P><M><E><E><E><E><E><A><A><V><A><E><K><E><P><K><S><Y><W><S><R><H><Y><I><V><D><L><L><A><V><V><V><P><A><V><P><T><V><A><W><L><C><R><S><Q><R><R><Q><G><Q><P><I><Y><N><I><S><S><L><L><R><G><C><C><T><V><A><L><H><S><I><R><R><I><S><C><R><S><L><S><Q><P><S><P><S><P><A><G><G><G><S><Q><L>
Inhibits SNARE complex formation by absorbing free syntaxin-1.<BOP>
O15079
Q99598
TSNAX_HUMAN
Translin-associated factor X
Homo
<M><S><N><K><E><G><S><G><G><F><R><K><R><K><H><D><N><F><P><H><N><Q><R><R><E><G><K><D><V><N><S><S><S><P><V><M><L><A><F><K><S><F><Q><Q><E><L><D><A><R><H><D><K><Y><E><R><L><V><K><L><S><R><D><I><T><V><E><S><K><R><T><I><F><L><L><H><R><I><T><S><A><P><D><M><E><D><I><L><T><E><S><E><I><K><L><D><G><V><R><Q><K><I><F><Q><V><A><Q><E><L><S><G><E><D><M><H><Q><F><H><R><A><I><T><T><G><L><Q><E><Y><V><E><A><V><S><F><Q><H><F><I><K><T><R><S><L><I><S><M><D><E><I><N><K><Q><L><I><F><T><T><E><D><N><G><K><E><N><K><T><P><S><S><D><A><Q><D><K><Q><F><G><T><W><R><L><R><V><T><P><V><D><Y><L><L><G><V><A><D><L><T><G><E><L><M><R><M><C><I><N><S><V><G><N><G><D><I><D><T><P><F><E><V><S><Q><F><L><R><Q><V><Y><D><G><F><S><F><I><G><N><T><G><P><Y><E><V><S><K><K><L><Y><T><L><K><Q><S><L><A><K><V><E><N><A><C><Y><A><L><K><V><R><G><S><E><I><P><K><H><M><L><A><D><V><F><S><V><K><T><E><M><I><D><Q><E><E><G><I><S>
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.<BOP>
Q99598
P00338
LDHA_HUMAN
Renal carcinoma antigen NY-REN-59
Homo
<M><A><T><L><K><D><Q><L><I><Y><N><L><L><K><E><E><Q><T><P><Q><N><K><I><T><V><V><G><V><G><A><V><G><M><A><C><A><I><S><I><L><M><K><D><L><A><D><E><L><A><L><V><D><V><I><E><D><K><L><K><G><E><M><M><D><L><Q><H><G><S><L><F><L><R><T><P><K><I><V><S><G><K><D><Y><N><V><T><A><N><S><K><L><V><I><I><T><A><G><A><R><Q><Q><E><G><E><S><R><L><N><L><V><Q><R><N><V><N><I><F><K><F><I><I><P><N><V><V><K><Y><S><P><N><C><K><L><L><I><V><S><N><P><V><D><I><L><T><Y><V><A><W><K><I><S><G><F><P><K><N><R><V><I><G><S><G><C><N><L><D><S><A><R><F><R><Y><L><M><G><E><R><L><G><V><H><P><L><S><C><H><G><W><V><L><G><E><H><G><D><S><S><V><P><V><W><S><G><M><N><V><A><G><V><S><L><K><T><L><H><P><D><L><G><T><D><K><D><K><E><Q><W><K><E><V><H><K><Q><V><V><E><S><A><Y><E><V><I><K><L><K><G><Y><T><S><W><A><I><G><L><S><V><A><D><L><A><E><S><I><M><K><N><L><R><R><V><H><P><V><S><T><M><I><K><G><L><Y><G><I><K><D><D><V><F><L><S><V><P><C><I><L><G><Q><N><G><I><S><D><L><V><K><V><T><L><T><S><E><E><E><A><R><L><K><K><S><A><D><T><L><W><G><I><Q><K><E><L><Q><F>
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).<BOP>
P00338
Q8NHJ6
LIRB4_HUMAN
Monocyte inhibitory receptor HM18
Homo
<M><I><P><T><F><T><A><L><L><C><L><G><L><S><L><G><P><R><T><H><M><Q><A><G><P><L><P><K><P><T><L><W><A><E><P><G><S><V><I><S><W><G><N><S><V><T><I><W><C><Q><G><T><L><E><A><R><E><Y><R><L><D><K><E><E><S><P><A><P><W><D><R><Q><N><P><L><E><P><K><N><K><A><R><F><S><I><P><S><M><T><E><D><Y><A><G><R><Y><R><C><Y><Y><R><S><P><V><G><W><S><Q><P><S><D><P><L><E><L><V><M><T><G><A><Y><S><K><P><T><L><S><A><L><P><S><P><L><V><T><S><G><K><S><V><T><L><L><C><Q><S><R><S><P><M><D><T><F><L><L><I><K><E><R><A><A><H><P><L><L><H><L><R><S><E><H><G><A><Q><Q><H><Q><A><E><F><P><M><S><P><V><T><S><V><H><G><G><T><Y><R><C><F><S><S><H><G><F><S><H><Y><L><L><S><H><P><S><D><P><L><E><L><I><V><S><G><S><L><E><D><P><R><P><S><P><T><R><S><V><S><T><A><A><G><P><E><D><Q><P><L><M><P><T><G><S><V><P><H><S><G><L><R><R><H><W><E><V><L><I><G><V><L><V><V><S><I><L><L><L><S><L><L><L><F><L><L><L><Q><H><W><R><Q><G><K><H><R><T><L><A><Q><R><Q><A><D><F><Q><R><P><P><G><A><A><E><P><E><P><K><D><G><G><L><Q><R><R><S><S><P><A><A><D><V><Q><G><E><N><F><C><A><A><V><K><N><T><Q><P><E><D><G><V><E><M><D><T><R><Q><S><P><H><D><E><D><P><Q><A><V><T><Y><A><K><V><K><H><S><R><P><R><R><E><M><A><S><P><P><S><P><L><S><G><E><F><L><D><T><K><D><R><Q><A><E><E><D><R><Q><M><D><T><E><A><A><A><S><E><A><P><Q><D><V><T><Y><A><Q><L><H><S><F><T><L><R><Q><K><A><T><E><P><P><P><S><Q><E><G><A><S><P><A><E><P><S><V><Y><A><T><L><A><I><H>
Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance . Receptor for FN1 . Receptor for apolipoprotein APOE . Receptor for ALCAM/CD166 . Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production . This inhibition of monocyte activation occurs at least in part via binding to FN1 . Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells . Induces up-regulation of CD86 on dendritic cells . Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation .<BOP>
Q8NHJ6
Q6PCE3
PGM2L_HUMAN
Phosphoglucomutase-2-like 1
Homo
<M><A><E><N><T><E><G><D><L><N><S><N><L><L><H><A><P><Y><H><T><G><D><P><Q><L><D><T><A><I><G><Q><W><L><R><W><D><K><N><P><K><T><K><E><Q><I><E><N><L><L><R><N><G><M><N><K><E><L><R><D><R><L><C><C><R><M><T><F><G><T><A><G><L><R><S><A><M><G><A><G><F><C><Y><I><N><D><L><T><V><I><Q><S><T><Q><G><M><Y><K><Y><L><E><R><C><F><S><D><F><K><Q><R><G><F><V><V><G><Y><D><T><R><G><Q><V><T><S><S><C><S><S><Q><R><L><A><K><L><T><A><A><V><L><L><A><K><D><V><P><V><Y><L><F><S><R><Y><V><P><T><P><F><V><P><Y><A><V><Q><K><L><K><A><V><A><G><V><M><I><T><A><S><H><N><R><K><E><D><N><G><Y><K><V><Y><W><E><T><G><A><Q><I><T><S><P><H><D><K><E><I><L><K><C><I><E><E><C><V><E><P><W><N><G><S><W><N><D><N><L><V><D><T><S><P><L><K><R><D><P><L><Q><D><I><C><R><R><Y><M><E><D><L><K><K><I><C><F><Y><R><E><L><N><S><K><T><T><L><K><F><V><H><T><S><F><H><G><V><G><H><D><Y><V><Q><L><A><F><K><V><F><G><F><K><P><P><I><P><V><P><E><Q><K><D><P><D><P><D><F><S><T><V><K><C><P><N><P><E><E><G><E><S><V><L><E><L><S><L><R><L><A><E><K><E><N><A><R><V><V><L><A><T><D><P><D><A><D><R><L><A><A><A><E><L><Q><E><N><G><C><W><K><V><F><T><G><N><E><L><A><A><L><F><G><W><W><M><F><D><C><W><K><K><N><K><S><R><N><A><D><V><K><N><V><Y><M><L><A><T><T><V><S><S><K><I><L><K><A><I><A><L><K><E><G><F><H><F><E><E><T><L><P><G><F><K><W><I><G><S><R><I><I><D><L><L><E><N><G><K><E><V><L><F><A><F><E><E><S><I><G><F><L><C><G><T><S><V><L><D><K><D><G><V><S><A><A><V><V><V><A><E><M><A><S><Y><L><E><T><M><N><I><T><L><K><Q><Q><L><V><K><V><Y><E><K><Y><G><Y><H><I><S><K><T><S><Y><F><L><C><Y><E><P><P><T><I><K><S><I><F><E><R><L><R><N><F><D><S><P><K><E><Y><P><K><F><C><G><T><F><A><I><L><H><V><R><D><V><T><T><G><Y><D><S><S><Q><P><N><K><K><S><V><L><P><V><S><K><N><S><Q><M><I><T><F><T><F><Q><N><G><C><V><A><T><L><R><T><S><G><T><E><P><K><I><K><Y><Y><A><E><M><C><A><S><P><D><Q><S><D><T><A><L><L><E><E><E><L><K><K><L><I><D><A><L><I><E><N><F><L><Q><P><S><K><N><G><L><I><W><R><S><V>
Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors . In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant .<BOP>
Q6PCE3
Q8NDV2
GPR26_HUMAN
G-protein coupled receptor 26
Homo
<M><N><S><W><D><A><G><L><A><G><L><L><V><G><T><M><G><V><S><L><L><S><N><A><L><V><L><L><C><L><L><H><S><A><D><I><R><R><Q><A><P><A><L><F><T><L><N><L><T><C><G><N><L><L><C><T><V><V><N><M><P><L><T><L><A><G><V><V><A><Q><R><Q><P><A><G><D><R><L><C><R><L><A><A><F><L><D><T><F><L><A><A><N><S><M><L><S><M><A><A><L><S><I><D><R><W><V><A><V><V><F><P><L><S><Y><R><A><K><M><R><L><R><D><A><A><L><M><V><A><Y><T><W><L><H><A><L><T><F><P><A><A><A><L><A><L><S><W><L><G><F><H><Q><L><Y><A><S><C><T><L><C><S><R><R><P><D><E><R><L><R><F><A><V><F><T><G><A><F><H><A><L><S><F><L><L><S><F><V><V><L><C><C><T><Y><L><K><V><L><K><V><A><R><F><H><C><K><R><I><D><V><I><T><M><Q><T><L><V><L><L><V><D><L><H><P><S><V><R><E><R><C><L><E><E><Q><K><R><R><R><Q><R><A><T><K><K><I><S><T><F><I><G><T><F><L><V><C><F><A><P><Y><V><I><T><R><L><V><E><L><F><S><T><V><P><I><G><S><H><W><G><V><L><S><K><C><L><A><Y><S><K><A><A><S><D><P><F><V><Y><S><L><L><R><H><Q><Y><R><K><S><C><K><E><I><L><N><R><L><L><H><R><R><S><I><H><S><S><G><L><T><G><D><S><H><S><Q><N><I><L><P><V><S><E>
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.<BOP>
Q8NDV2
Q9P1U1
ARP3B_HUMAN
Actin-related protein ARP4
Homo
<M><A><G><S><L><P><P><C><V><V><D><C><G><T><G><Y><T><K><L><G><Y><A><G><N><T><E><P><Q><F><I><I><P><S><C><I><A><I><R><E><S><A><K><V><V><D><Q><A><Q><R><R><V><L><R><G><V><D><D><L><D><F><F><I><G><D><E><A><I><D><K><P><T><Y><A><T><K><W><P><I><R><H><G><I><I><E><D><W><D><L><M><E><R><F><M><E><Q><V><V><F><K><Y><L><R><A><E><P><E><D><H><Y><F><L><M><T><E><P><P><L><N><T><P><E><N><R><E><Y><L><A><E><I><M><F><E><S><F><N><V><P><G><L><Y><I><A><V><Q><A><V><L><A><L><A><A><S><W><T><S><R><Q><V><G><E><R><T><L><T><G><I><V><I><D><S><G><D><G><V><T><H><V><I><P><V><A><E><G><Y><V><I><G><S><C><I><K><H><I><P><I><A><G><R><D><I><T><Y><F><I><Q><Q><L><L><R><E><R><E><V><G><I><P><P><E><Q><S><L><E><T><A><K><A><I><K><E><K><Y><C><Y><I><C><P><D><I><V><K><E><F><A><K><Y><D><V><D><P><R><K><W><I><K><Q><Y><T><G><I><N><A><I><N><Q><K><K><F><V><I><D><V><G><Y><E><R><F><L><G><P><E><I><F><F><H><P><E><F><A><N><P><D><F><M><E><S><I><S><D><V><V><D><E><V><I><Q><N><C><P><I><D><V><R><R><P><L><Y><K><N><V><V><L><S><G><G><S><T><M><F><R><D><F><G><R><R><L><Q><R><D><L><K><R><V><V><D><A><R><L><R><L><S><E><E><L><S><G><G><R><I><K><P><K><P><V><E><V><Q><V><V><T><H><H><M><Q><R><Y><A><V><W><F><G><G><S><M><L><A><S><T><P><E><F><F><Q><V><C><H><T><K><K><D><Y><E><E><Y><G><P><S><I><C><R><H><N><P><V><F><G><V><M><S>
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.<BOP>
Q9P1U1
Q9P0J7
KCMF1_HUMAN
ZZ-type zinc finger-containing protein 1
Homo
<M><S><R><H><E><G><V><S><C><D><A><C><L><K><G><N><F><R><G><R><R><Y><K><C><L><I><C><Y><D><Y><D><L><C><A><S><C><Y><E><S><G><A><T><T><T><R><H><T><T><D><H><P><M><Q><C><I><L><T><R><V><D><F><D><L><Y><Y><G><G><E><A><F><S><V><E><Q><P><Q><S><F><T><C><P><Y><C><G><K><M><G><Y><T><E><T><S><L><Q><E><H><V><T><S><E><H><A><E><T><S><T><E><V><I><C><P><I><C><A><A><L><P><G><G><D><P><N><H><V><T><D><D><F><A><A><H><L><T><L><E><H><R><A><P><R><D><L><D><E><S><S><G><V><R><H><V><R><R><M><F><H><P><G><R><G><L><G><G><P><R><A><R><R><S><N><M><H><F><T><S><S><S><T><G><G><L><S><S><S><Q><S><S><Y><S><P><S><N><R><E><A><M><D><P><I><A><E><L><L><S><Q><L><S><G><V><R><R><S><A><G><G><Q><L><N><S><S><G><P><S><A><S><Q><L><Q><Q><L><Q><M><Q><L><Q><L><E><R><Q><H><A><Q><A><A><R><Q><Q><L><E><T><A><R><N><A><T><R><R><T><N><T><S><S><V><T><T><T><I><T><Q><S><T><A><T><T><N><I><A><N><T><E><S><S><Q><Q><T><L><Q><N><S><Q><F><L><L><T><R><L><N><D><P><K><M><S><E><T><E><R><Q><S><M><E><S><E><R><A><D><R><S><L><F><V><Q><E><L><L><L><S><T><L><V><R><E><E><S><S><S><S><D><E><D><D><R><G><E><M><A><D><F><G><A><M><G><C><V><D><I><M><P><L><D><V><A><L><E><N><L><N><L><K><E><S><N><K><G><N><E><P><P><P><P><P><L>
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.<BOP>
Q9P0J7
Q9NX62
IMPA3_HUMAN
Phosphoadenosine phosphate 3'-nucleotidase
Homo
<M><A><P><M><G><I><R><L><S><P><L><G><V><A><V><F><C><L><L><G><L><G><V><L><Y><H><L><Y><S><G><F><L><A><G><R><F><S><L><F><G><L><G><G><E><P><G><G><G><A><A><G><P><A><A><A><A><D><G><G><T><V><D><L><R><E><M><L><A><V><S><V><L><A><A><V><R><G><G><D><E><V><R><R><V><R><E><S><N><V><L><H><E><K><S><K><G><K><T><R><E><G><A><E><D><K><M><T><S><G><D><V><L><S><N><R><K><M><F><Y><L><L><K><T><A><F><P><S><V><Q><I><N><T><E><E><H><V><D><A><A><D><Q><E><V><I><L><W><D><H><K><I><P><E><D><I><L><K><E><V><T><T><P><K><E><V><P><A><E><S><V><T><V><W><I><D><P><L><D><A><T><Q><E><Y><T><E><D><L><R><K><Y><V><T><T><M><V><C><V><A><V><N><G><K><P><M><L><G><V><I><H><K><P><F><S><E><Y><T><A><W><A><M><V><D><G><G><S><N><V><K><A><R><S><S><Y><N><E><K><T><P><R><I><V><V><S><R><S><H><S><G><M><V><K><Q><V><A><L><Q><T><F><G><N><Q><T><T><I><I><P><A><G><G><A><G><Y><K><V><L><A><L><L><D><V><P><D><K><S><Q><E><K><A><D><L><Y><I><H><V><T><Y><I><K><K><W><D><I><C><A><G><N><A><I><L><K><A><L><G><G><H><M><T><T><L><S><G><E><E><I><S><Y><T><G><S><D><G><I><E><G><G><L><L><A><S><I><R><M><N><H><Q><A><L><V><R><K><L><P><D><L><E><K><T><G><H><K>
Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.<BOP>
Q9NX62
P29372
3MG_HUMAN
N-methylpurine-DNA glycosylase
Homo
<M><V><T><P><A><L><Q><M><K><K><P><K><Q><F><C><R><R><M><G><Q><K><K><Q><R><P><A><R><A><G><Q><P><H><S><S><S><D><A><A><Q><A><P><A><E><Q><P><H><S><S><S><D><A><A><Q><A><P><C><P><R><E><R><C><L><G><P><P><T><T><P><G><P><Y><R><S><I><Y><F><S><S><P><K><G><H><L><T><R><L><G><L><E><F><F><D><Q><P><A><V><P><L><A><R><A><F><L><G><Q><V><L><V><R><R><L><P><N><G><T><E><L><R><G><R><I><V><E><T><E><A><Y><L><G><P><E><D><E><A><A><H><S><R><G><G><R><Q><T><P><R><N><R><G><M><F><M><K><P><G><T><L><Y><V><Y><I><I><Y><G><M><Y><F><C><M><N><I><S><S><Q><G><D><G><A><C><V><L><L><R><A><L><E><P><L><E><G><L><E><T><M><R><Q><L><R><S><T><L><R><K><G><T><A><S><R><V><L><K><D><R><E><L><C><S><G><P><S><K><L><C><Q><A><L><A><I><N><K><S><F><D><Q><R><D><L><A><Q><D><E><A><V><W><L><E><R><G><P><L><E><P><S><E><P><A><V><V><A><A><A><R><V><G><V><G><H><A><G><E><W><A><R><K><P><L><R><F><Y><V><R><G><S><P><W><V><S><V><V><D><R><V><A><E><Q><D><T><Q><A>
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.<BOP>
P29372
Q86WV6
STING_HUMAN
Transmembrane protein 173
Homo
<M><P><H><S><S><L><H><P><S><I><P><C><P><R><G><H><G><A><Q><K><A><A><L><V><L><L><S><A><C><L><V><T><L><W><G><L><G><E><P><P><E><H><T><L><R><Y><L><V><L><H><L><A><S><L><Q><L><G><L><L><L><N><G><V><C><S><L><A><E><E><L><R><H><I><H><S><R><Y><R><G><S><Y><W><R><T><V><R><A><C><L><G><C><P><L><R><R><G><A><L><L><L><L><S><I><Y><F><Y><Y><S><L><P><N><A><V><G><P><P><F><T><W><M><L><A><L><L><G><L><S><Q><A><L><N><I><L><L><G><L><K><G><L><A><P><A><E><I><S><A><V><C><E><K><G><N><F><N><V><A><H><G><L><A><W><S><Y><Y><I><G><Y><L><R><L><I><L><P><E><L><Q><A><R><I><R><T><Y><N><Q><H><Y><N><N><L><L><R><G><A><V><S><Q><R><L><Y><I><L><L><P><L><D><C><G><V><P><D><N><L><S><M><A><D><P><N><I><R><F><L><D><K><L><P><Q><Q><T><G><D><H><A><G><I><K><D><R><V><Y><S><N><S><I><Y><E><L><L><E><N><G><Q><R><A><G><T><C><V><L><E><Y><A><T><P><L><Q><T><L><F><A><M><S><Q><Y><S><Q><A><G><F><S><R><E><D><R><L><E><Q><A><K><L><F><C><R><T><L><E><D><I><L><A><D><A><P><E><S><Q><N><N><C><R><L><I><A><Y><Q><E><P><A><D><D><S><S><F><S><L><S><Q><E><V><L><R><H><L><R><Q><E><E><K><E><E><V><T><V><G><S><L><K><T><S><A><V><P><S><T><S><T><M><S><Q><E><P><E><L><L><I><S><G><M><E><K><P><L><P><L><R><T><D><F><S>
(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein . Such oncoproteins prevent the ability to sense cytosolic DNA .<BOP>
Q86WV6
O14828
SCAM3_HUMAN
Secretory carrier-associated membrane protein 3
Homo
<M><A><Q><S><R><D><G><G><N><P><F><A><E><P><S><E><L><D><N><P><F><Q><D><P><A><V><I><Q><H><R><P><S><R><Q><Y><A><T><L><D><V><Y><N><P><F><E><T><R><E><P><P><P><A><Y><E><P><P><A><P><A><P><L><P><P><P><S><A><P><S><L><Q><P><S><R><K><L><S><P><T><E><P><K><N><Y><G><S><Y><S><T><Q><A><S><A><A><A><A><T><A><E><L><L><K><K><Q><E><E><L><N><R><K><A><E><E><L><D><R><R><E><R><E><L><Q><H><A><A><L><G><G><T><A><T><R><Q><N><N><W><P><P><L><P><S><F><C><P><V><Q><P><C><F><F><Q><D><I><S><M><E><I><P><Q><E><F><Q><K><T><V><S><T><M><Y><Y><L><W><M><C><S><T><L><A><L><L><L><N><F><L><A><C><L><A><S><F><C><V><E><T><N><N><G><A><G><F><G><L><S><I><L><W><V><L><L><F><T><P><C><S><F><V><C><W><Y><R><P><M><Y><K><A><F><R><S><D><S><S><F><N><F><F><V><F><F><F><I><F><F><V><Q><D><V><L><F><V><L><Q><A><I><G><I><P><G><W><G><F><S><G><W><I><S><A><L><V><V><P><K><G><N><T><A><V><S><V><L><M><L><L><V><A><L><L><F><T><G><I><A><V><L><G><I><V><M><L><K><R><I><H><S><L><Y><R><R><T><G><A><S><F><Q><K><A><Q><Q><E><F><A><A><G><V><F><S><N><P><A><V><R><T><A><A><A><N><A><A><A><G><A><A><E><N><A><F><R><A><P>
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.<BOP>
O14828
P09238
MMP10_HUMAN
Transin-2
Homo
<M><M><H><L><A><F><L><V><L><L><C><L><P><V><C><S><A><Y><P><L><S><G><A><A><K><E><E><D><S><N><K><D><L><A><Q><Q><Y><L><E><K><Y><Y><N><L><E><K><D><V><K><Q><F><R><R><K><D><S><N><L><I><V><K><K><I><Q><G><M><Q><K><F><L><G><L><E><V><T><G><K><L><D><T><D><T><L><E><V><M><R><K><P><R><C><G><V><P><D><V><G><H><F><S><S><F><P><G><M><P><K><W><R><K><T><H><L><T><Y><R><I><V><N><Y><T><P><D><L><P><R><D><A><V><D><S><A><I><E><K><A><L><K><V><W><E><E><V><T><P><L><T><F><S><R><L><Y><E><G><E><A><D><I><M><I><S><F><A><V><K><E><H><G><D><F><Y><S><F><D><G><P><G><H><S><L><A><H><A><Y><P><P><G><P><G><L><Y><G><D><I><H><F><D><D><D><E><K><W><T><E><D><A><S><G><T><N><L><F><L><V><A><A><H><E><L><G><H><S><L><G><L><F><H><S><A><N><T><E><A><L><M><Y><P><L><Y><N><S><F><T><E><L><A><Q><F><R><L><S><Q><D><D><V><N><G><I><Q><S><L><Y><G><P><P><P><A><S><T><E><E><P><L><V><P><T><K><S><V><P><S><G><S><E><M><P><A><K><C><D><P><A><L><S><F><D><A><I><S><T><L><R><G><E><Y><L><F><F><K><D><R><Y><F><W><R><R><S><H><W><N><P><E><P><E><F><H><L><I><S><A><F><W><P><S><L><P><S><Y><L><D><A><A><Y><E><V><N><S><R><D><T><V><F><I><F><K><G><N><E><F><W><A><I><R><G><N><E><V><Q><A><G><Y><P><R><G><I><H><T><L><G><F><P><P><T><I><R><K><I><D><A><A><V><S><D><K><E><K><K><K><T><Y><F><F><A><A><D><K><Y><W><R><F><D><E><N><S><Q><S><M><E><Q><G><F><P><R><L><I><A><D><D><F><P><G><V><E><P><K><V><D><A><V><L><Q><A><F><G><F><F><Y><F><F><S><G><S><S><Q><F><E><F><D><P><N><A><R><M><V><T><H><I><L><K><S><N><S><W><L><H><C>
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.<BOP>
P09238
Q86VI1
EX3L1_HUMAN
Protein Jiangli
Homo
<M><D><S><A><A><K><D><E><M><Q><P><A><L><S><P><G><P><E><W><P><E><Q><E><R><A><E><Q><L><A><R><G><A><A><L><K><W><A><S><G><I><F><Y><R><P><E><Q><L><A><R><L><G><Q><Y><R><S><R><E><V><Q><R><T><C><S><L><E><S><R><L><K><S><V><M><Q><S><Y><L><E><G><V><Q><T><G><V><W><Q><L><A><Q><A><I><E><V><V><Q><G><T><R><E><A><L><S><Q><A><R><G><L><L><Q><G><M><S><Q><A><L><Q><T><L><E><P><L><R><E><R><V><A><Q><H><K><Q><L><Q><A><L><S><H><L><L><P><R><L><R><A><V><P><A><A><V><S><H><T><Q><T><L><I><D><G><Q><Q><F><L><E><A><Y><V><S><L><R><E><L><E><Q><L><R><E><D><T><W><A><P><L><G><G><L><E><L><P><V><F><Q><G><L><D><L><L><F><E><A><L><G><Q><A><V><E><A><A><A><G><A><A><G><K><L><A><R><E><D><P><A><L><L><V><A><A><V><R><V><A><E><V><E><T><G><R><T><T><P><L><G><Q><V><P><R><D><W><R><Q><R><C><L><R><A><L><Q><E><G><L><E><Q><A><H><F><G><S><P><L><L><P><A><P><G><A><L><P><G><W><L><E><A><L><R><V><A><L><P><V><E><L><A><T><A><E><A><L><V><A><P><C><C><P><P><Q><Y><N><V><V><Q><L><W><A><H><T><L><H><S><G><L><R><R><S><L><Q><N><L><L><A><G><P><E><L><E><A><A><D><A><F><A><L><L><H><W><A><L><H><V><Y><L><G><Q><E><M><M><G><S><L><E><L><G><P><E><A><D><V><S><Q><L><E><P><L><L><T><L><E><N><I><E><Q><L><E><A><T><F><V><A><N><I><Q><A><S><V><S><Q><W><L><Q><N><A><L><D><G><E><V><A><E><W><G><R><E><H><G><P><N><T><D><P><S><G><S><Y><Y><S><P><M><P><A><I><V><L><Q><I><L><E><E><N><I><R><V><A><S><L><V><S><E><S><L><Q><Q><R><V><H><G><M><A><L><S><E><L><G><T><F><L><R><S><F><S><D><A><L><I><R><F><S><R><D><H><F><R><G><K><S><M><A><P><H><Y><V><P><Y><L><L><A><A><L><N><H><K><S><A><L><S><S><S><V><S><V><L><Q><L><D><G><A><P><S><G><A><L><A><P><V><E><A><A><L><D><E><L><Q><R><R><I><Y><R><L><V><L><E><A><L><Q><A><E><L><Q><P><L><F><A><D><L><P><S><R><Q><W><L><S><S><P><E><L><L><Q><S><V><C><E><R><T><G><R><F><C><R><D><F><W><R><V><R><N><P><T><V><Q><L><L><L><A><E><A><E><R><A><V><V><L><Q><Y><L><S><A><L><M><Q><G><R><L><V><C><R><G><A><D><E><R><T><Q><A><A><E><R><L><R><H><D><A><A><Q><L><Q><Q><L><F><L><S><L><G><L><E><E><N><A><H><C><A><P><V><L><L><A><L><R><E><L><L><N><L><R><D><P><A><L><L><G><L><E><V><A><G><L><R><Q><Q><F><P><D><V><S><E><D><H><V><S><A><L><L><G><L><R><G><D><L><S><R><E><Q><H><L><A><A><L><S><S><L><Q><A><A><L><P><P><S><P><R><A><S><R><R><V><L><F><S><L><V><P><A><P><A><L><A><P><A><S><C><L><P><S><G><S><C><A><R><A><L><L><L><A><E>
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.<BOP>
Q86VI1
Q6ZS10
CL17A_HUMAN
Prolectin
Homo
<M><H><N><L><Y><S><I><T><G><Y><P><D><P><P><G><T><M><E><E><E><E><E><D><D><D><Y><E><N><S><T><P><P><Y><K><D><L><P><P><K><P><G><T><M><E><E><E><E><E><D><D><D><Y><E><N><S><T><P><P><Y><K><D><L><P><P><K><P><G><T><M><E><E><E><E><E><D><D><D><Y><E><N><S><T><P><P><Y><K><D><L><P><P><K><P><G><S><S><A><P><P><R><P><P><R><A><A><K><E><T><E><K><P><P><L><P><C><K><P><R><N><M><T><G><L><D><L><A><A><V><T><C><P><P><P><Q><L><A><V><N><L><E><P><S><P><L><Q><P><S><L><A><A><T><P><V><P><W><L><N><Q><R><S><G><G><P><G><C><C><Q><K><R><W><M><V><Y><L><C><L><L><V><V><T><S><L><F><L><G><C><L><G><L><T><V><T><L><I><K><Y><Q><E><L><M><E><E><L><R><M><L><S><F><Q><Q><M><T><W><R><T><N><M><T><G><M><A><G><L><A><G><L><K><H><D><I><A><R><V><R><A><D><T><N><Q><S><L><V><E><L><W><G><L><L><D><C><R><R><I><T><C><P><E><G><W><L><P><F><E><G><K><C><Y><Y><F><S><P><S><T><K><S><W><D><E><A><R><M><F><C><Q><E><N><Y><S><H><L><V><I><I><N><S><F><A><E><H><N><F><V><A><K><A><H><G><S><P><R><V><Y><W><L><G><L><N><D><R><A><Q><E><G><D><W><R><W><L><D><G><S><P><V><T><L><S><F><W><E><P><E><E><P><N><N><I><H><D><E><D><C><A><T><M><N><K><G><G><T><W><N><D><L><S><C><Y><K><T><T><Y><W><I><C><E><R><K><C><S><C>
Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.<BOP>
Q6ZS10
P32238
CCKAR_HUMAN
Cholecystokinin-1 receptor
Homo
<M><D><V><V><D><S><L><L><V><N><G><S><N><I><T><P><P><C><E><L><G><L><E><N><E><T><L><F><C><L><D><Q><P><R><P><S><K><E><W><Q><P><A><V><Q><I><L><L><Y><S><L><I><F><L><L><S><V><L><G><N><T><L><V><I><T><V><L><I><R><N><K><R><M><R><T><V><T><N><I><F><L><L><S><L><A><V><S><D><L><M><L><C><L><F><C><M><P><F><N><L><I><P><N><L><L><K><D><F><I><F><G><S><A><V><C><K><T><T><T><Y><F><M><G><T><S><V><S><V><S><T><F><N><L><V><A><I><S><L><E><R><Y><G><A><I><C><K><P><L><Q><S><R><V><W><Q><T><K><S><H><A><L><K><V><I><A><A><T><W><C><L><S><F><T><I><M><T><P><Y><P><I><Y><S><N><L><V><P><F><T><K><N><N><N><Q><T><A><N><M><C><R><F><L><L><P><N><D><V><M><Q><Q><S><W><H><T><F><L><L><L><I><L><F><L><I><P><G><I><V><M><M><V><A><Y><G><L><I><S><L><E><L><Y><Q><G><I><K><F><E><A><S><Q><K><K><S><A><K><E><R><K><P><S><T><T><S><S><G><K><Y><E><D><S><D><G><C><Y><L><Q><K><T><R><P><P><R><K><L><E><L><R><Q><L><S><T><G><S><S><S><R><A><N><R><I><R><S><N><S><S><A><A><N><L><M><A><K><K><R><V><I><R><M><L><I><V><I><V><V><L><F><F><L><C><W><M><P><I><F><S><A><N><A><W><R><A><Y><D><T><A><S><A><E><R><R><L><S><G><T><P><I><S><F><I><L><L><L><S><Y><T><S><S><C><V><N><P><I><I><Y><C><F><M><N><K><R><F><R><L><G><F><M><A><T><F><P><C><C><P><N><P><G><P><P><G><A><R><G><E><V><G><E><E><E><E><G><G><T><T><G><A><S><L><S><R><F><S><Y><S><H><M><S><A><S><V><P><P><Q>
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<BOP>
P32238
A8MUZ8
Z705G_HUMAN
Putative zinc finger protein 705G
Homo
<M><H><S><L><K><K><L><T><F><E><D><V><A><I><D><F><T><Q><E><E><W><A><M><M><D><T><S><K><R><K><L><Y><R><D><V><M><L><E><N><I><S><H><L><V><S><L><G><Y><Q><I><S><K><S><Y><I><I><L><Q><L><E><Q><G><K><E><L><W><R><E><G><R><V><F><L><Q><D><Q><N><P><N><R><E><S><A><L><K><K><T><H><M><I><S><M><H><P><I><T><R><K><D><A><S><T><S><M><T><M><E><N><S><L><I><L><E><D><P><F><E><C><N><D><S><G><E><D><C><T><R><S><S><T><I><T><Q><C><L><L><T><H><S><G><K><K><P><Y><V><S><K><Q><C><G><K><S><L><R><N><L><L><S><T><E><P><H><K><Q><I><H><T><K><G><K><S><Y><Q><C><N><L><C><E><K><A><Y><T><N><C><F><H><L><R><R><H><K><M><T><H><T><G><E><R><P><Y><A><C><H><L><C><R><K><A><F><T><Q><C><S><H><L><R><R><H><E><K><T><H><T><G><Q><R><P><Y><K><C><H><Q><Y><G><K><V><F><I><Q><S><F><N><L><Q><R><H><E><R><T><H><L><G><K><K><C><Y><E><C><D><K><S><G><K><A><F><S><Q><S><S><G><F><R><G><N><K><I><I><H><T><G><E><K><P><H><A><C><L><L><C><G><K><A><F><S><L><S><S><N><L><R>
May be involved in transcriptional regulation.<BOP>
A8MUZ8
Q9UBB5
MBD2_HUMAN
Methyl-CpG-binding protein MBD2
Homo
<M><R><A><H><P><G><G><G><R><C><C><P><E><Q><E><E><G><E><S><A><A><G><G><S><G><A><G><G><D><S><A><I><E><Q><G><G><Q><G><S><A><L><A><P><S><P><V><S><G><V><R><R><E><G><A><R><G><G><G><R><G><R><G><R><W><K><Q><A><G><R><G><G><G><V><C><G><R><G><R><G><R><G><R><G><R><G><R><G><R><G><R><G><R><G><R><G><R><P><P><S><G><G><S><G><L><G><G><D><G><G><G><C><G><G><G><G><S><G><G><G><G><A><P><R><R><E><P><V><P><F><P><S><G><S><A><G><P><G><P><R><G><P><R><A><T><E><S><G><K><R><M><D><C><P><A><L><P><P><G><W><K><K><E><E><V><I><R><K><S><G><L><S><A><G><K><S><D><V><Y><Y><F><S><P><S><G><K><K><F><R><S><K><P><Q><L><A><R><Y><L><G><N><T><V><D><L><S><S><F><D><F><R><T><G><K><M><M><P><S><K><L><Q><K><N><K><Q><R><L><R><N><D><P><L><N><Q><N><K><G><K><P><D><L><N><T><T><L><P><I><R><Q><T><A><S><I><F><K><Q><P><V><T><K><V><T><N><H><P><S><N><K><V><K><S><D><P><Q><R><M><N><E><Q><P><R><Q><L><F><W><E><K><R><L><Q><G><L><S><A><S><D><V><T><E><Q><I><I><K><T><M><E><L><P><K><G><L><Q><G><V><G><P><G><S><N><D><E><T><L><L><S><A><V><A><S><A><L><H><T><S><S><A><P><I><T><G><Q><V><S><A><A><V><E><K><N><P><A><V><W><L><N><T><S><Q><P><L><C><K><A><F><I><V><T><D><E><D><I><R><K><Q><E><E><R><V><Q><Q><V><R><K><K><L><E><E><A><L><M><A><D><I><L><S><R><A><A><D><T><E><E><M><D><I><E><M><D><S><G><D><E><A>
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<BOP>
Q9UBB5
P14406
CX7A2_HUMAN
Cytochrome c oxidase subunit VIIa-liver/heart
Homo
<M><L><R><N><L><L><A><L><R><Q><I><G><Q><R><T><I><S><T><A><S><R><R><H><F><K><N><K><V><P><E><K><Q><K><L><F><Q><E><D><D><E><I><P><L><Y><L><K><G><G><V><A><D><A><L><L><Y><R><A><T><M><I><L><T><V><G><G><T><A><Y><A><I><Y><E><L><A><V><A><S><F><P><K><K><Q><E>
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from
P14406
P45983
MK08_HUMAN
c-Jun N-terminal kinase 1
Homo
<M><S><R><S><K><R><D><N><N><F><Y><S><V><E><I><G><D><S><T><F><T><V><L><K><R><Y><Q><N><L><K><P><I><G><S><G><A><Q><G><I><V><C><A><A><Y><D><A><I><L><E><R><N><V><A><I><K><K><L><S><R><P><F><Q><N><Q><T><H><A><K><R><A><Y><R><E><L><V><L><M><K><C><V><N><H><K><N><I><I><G><L><L><N><V><F><T><P><Q><K><S><L><E><E><F><Q><D><V><Y><I><V><M><E><L><M><D><A><N><L><C><Q><V><I><Q><M><E><L><D><H><E><R><M><S><Y><L><L><Y><Q><M><L><C><G><I><K><H><L><H><S><A><G><I><I><H><R><D><L><K><P><S><N><I><V><V><K><S><D><C><T><L><K><I><L><D><F><G><L><A><R><T><A><G><T><S><F><M><M><T><P><Y><V><V><T><R><Y><Y><R><A><P><E><V><I><L><G><M><G><Y><K><E><N><V><D><L><W><S><V><G><C><I><M><G><E><M><V><C><H><K><I><L><F><P><G><R><D><Y><I><D><Q><W><N><K><V><I><E><Q><L><G><T><P><C><P><E><F><M><K><K><L><Q><P><T><V><R><T><Y><V><E><N><R><P><K><Y><A><G><Y><S><F><E><K><L><F><P><D><V><L><F><P><A><D><S><E><H><N><K><L><K><A><S><Q><A><R><D><L><L><S><K><M><L><V><I><D><A><S><K><R><I><S><V><D><E><A><L><Q><H><P><Y><I><N><V><W><Y><D><P><S><E><A><E><A><P><P><P><K><I><P><D><K><Q><L><D><E><R><E><H><T><I><E><E><W><K><E><L><I><Y><K><E><V><M><D><L><E><E><R><T><K><N><G><V><I><R><G><Q><P><S><P><L><G><A><A><V><I><N><G><S><Q><H><P><S><S><S><S><S><V><N><D><V><S><S><M><S><T><D><P><T><L><A><S><D><T><D><S><S><L><E><A><A><A><G><P><L><G><C><C><R>
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.<BOP>
P45983
O75072
FKTN_HUMAN
Ribitol-5-phosphate transferase
Homo
<M><S><R><I><N><K><N><V><V><L><A><L><L><T><L><T><S><S><A><F><L><L><F><Q><L><Y><Y><Y><K><H><Y><L><S><T><K><N><G><A><G><L><S><K><S><K><G><S><R><I><G><F><D><S><T><Q><W><R><A><V><K><K><F><I><M><L><T><S><N><Q><N><V><P><V><F><L><I><D><P><L><I><L><E><L><I><N><K><N><F><E><Q><V><K><N><T><S><H><G><S><T><S><Q><C><K><F><F><C><V><P><R><D><F><T><A><F><A><L><Q><Y><H><L><W><K><N><E><E><G><W><F><R><I><A><E><N><M><G><F><Q><C><L><K><I><E><S><K><D><P><R><L><D><G><I><D><S><L><S><G><T><E><I><P><L><H><Y><I><C><K><L><A><T><H><A><I><H><L><V><V><F><H><E><R><S><G><N><Y><L><W><H><G><H><L><R><L><K><E><H><I><D><R><K><F><V><P><F><R><K><L><Q><F><G><R><Y><P><G><A><F><D><R><P><E><L><Q><Q><V><T><V><D><G><L><E><V><L><I><P><K><D><P><M><H><F><V><E><E><V><P><H><S><R><F><I><E><C><R><Y><K><E><A><R><A><F><F><Q><Q><Y><L><D><D><N><T><V><E><A><V><A><F><R><K><S><A><K><E><L><L><Q><L><A><A><K><T><L><N><K><L><G><V><P><F><W><L><S><S><G><T><C><L><G><W><Y><R><Q><C><N><I><I><P><Y><S><K><D><V><D><L><G><I><F><I><Q><D><Y><K><S><D><I><I><L><A><F><Q><D><A><G><L><P><L><K><H><K><F><G><K><V><E><D><S><L><E><L><S><F><Q><G><K><D><D><V><K><L><D><V><F><F><F><Y><E><E><T><D><H><M><W><N><G><G><T><Q><A><K><T><G><K><K><F><K><Y><L><F><P><K><F><T><L><C><W><T><E><F><V><D><M><K><V><H><V><P><C><E><T><L><E><Y><I><E><A><N><Y><G><K><T><W><K><I><P><V><K><T><W><D><W><K><R><S><P><P><N><V><Q><P><N><G><I><W><P><I><S><E><W><D><E><V><I><Q><L><Y>
Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) . This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 . Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity . May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes . Could be involved in brain development (Probable).<BOP>
O75072
Q8WVP5
TP8L1_HUMAN
Oxidative stress-regulated gene-beta
Homo
<M><D><T><F><S><T><K><S><L><A><L><Q><A><Q><K><K><L><L><S><K><M><A><S><K><A><V><V><A><V><L><V><D><D><T><S><S><E><V><L><D><E><L><Y><R><A><T><R><E><F><T><R><S><R><K><E><A><Q><K><M><L><K><N><L><V><K><V><A><L><K><L><G><L><L><L><R><G><D><Q><L><G><G><E><E><L><A><L><L><R><R><F><R><H><R><A><R><C><L><A><M><T><A><V><S><F><H><Q><V><D><F><T><F><D><R><R><V><L><A><A><G><L><L><E><C><R><D><L><L><H><Q><A><V><G><P><H><L><T><A><K><S><H><G><R><I><N><H><V><F><G><H><L><A><D><C><D><F><L><A><A><L><Y><G><P><A><E><P><Y><R><S><H><L><R><R><I><C><E><G><L><G><R><M><L><D><E><G><S><L>
Acts as a negative regulator of mTOR activity.<BOP>
Q8WVP5
P56202
CATW_HUMAN
Lymphopain
Homo
<M><A><L><T><A><H><P><S><C><L><L><A><L><L><V><A><G><L><A><Q><G><I><R><G><P><L><R><A><Q><D><L><G><P><Q><P><L><E><L><K><E><A><F><K><L><F><Q><I><Q><F><N><R><S><Y><L><S><P><E><E><H><A><H><R><L><D><I><F><A><H><N><L><A><Q><A><Q><R><L><Q><E><E><D><L><G><T><A><E><F><G><V><T><P><F><S><D><L><T><E><E><E><F><G><Q><L><Y><G><Y><R><R><A><A><G><G><V><P><S><M><G><R><E><I><R><S><E><E><P><E><E><S><V><P><F><S><C><D><W><R><K><V><A><S><A><I><S><P><I><K><D><Q><K><N><C><N><C><C><W><A><M><A><A><A><G><N><I><E><T><L><W><R><I><S><F><W><D><F><V><D><V><S><V><Q><E><L><L><D><C><G><R><C><G><D><G><C><H><G><G><F><V><W><D><A><F><I><T><V><L><N><N><S><G><L><A><S><E><K><D><Y><P><F><Q><G><K><V><R><A><H><R><C><H><P><K><K><Y><Q><K><V><A><W><I><Q><D><F><I><M><L><Q><N><N><E><H><R><I><A><Q><Y><L><A><T><Y><G><P><I><T><V><T><I><N><M><K><P><L><Q><L><Y><R><K><G><V><I><K><A><T><P><T><T><C><D><P><Q><L><V><D><H><S><V><L><L><V><G><F><G><S><V><K><S><E><E><G><I><W><A><E><T><V><S><S><Q><S><Q><P><Q><P><P><H><P><T><P><Y><W><I><L><K><N><S><W><G><A><Q><W><G><E><K><G><Y><F><R><L><H><R><G><S><N><T><C><G><I><T><K><F><P><L><T><A><R><V><Q><K><P><D><M><K><P><R><V><S><C><P><P>
(Microbial infection) Plays a role during influenza virus infection in lungs cells ex vivo. Acts at the level of virus entering host cytoplasm from late endosome.<BOP>
P56202
Q9BW91
NUDT9_HUMAN
Nucleoside diphosphate-linked moiety X motif 9
Homo
<M><A><G><R><L><L><G><K><A><L><A><A><V><S><L><S><L><A><L><A><S><V><T><I><R><S><S><R><C><R><G><I><Q><A><F><R><N><S><F><S><S><S><W><F><H><L><N><T><N><V><M><S><G><S><N><G><S><K><E><N><S><H><N><K><A><R><T><S><P><Y><P><G><S><K><V><E><R><S><Q><V><P><N><E><K><V><G><W><L><V><E><W><Q><D><Y><K><P><V><E><Y><T><A><V><S><V><L><A><G><P><R><W><A><D><P><Q><I><S><E><S><N><F><S><P><K><F><N><E><K><D><G><H><V><E><R><K><S><K><N><G><L><Y><E><I><E><N><G><R><P><R><N><P><A><G><R><T><G><L><V><G><R><G><L><L><G><R><W><G><P><N><H><A><A><D><P><I><I><T><R><W><K><R><D><S><S><G><N><K><I><M><H><P><V><S><G><K><H><I><L><Q><F><V><A><I><K><R><K><D><C><G><E><W><A><I><P><G><G><M><V><D><P><G><E><K><I><S><A><T><L><K><R><E><F><G><E><E><A><L><N><S><L><Q><K><T><S><A><E><K><R><E><I><E><E><K><L><H><K><L><F><S><Q><D><H><L><V><I><Y><K><G><Y><V><D><D><P><R><N><T><D><N><A><W><M><E><T><E><A><V><N><Y><H><D><E><T><G><E><I><M><D><N><L><M><L><E><A><G><D><D><A><G><K><V><K><W><V><D><I><N><D><K><L><K><L><Y><A><S><H><S><Q><F><I><K><L><V><A><E><K><R><D><A><H><W><S><E><D><S><E><A><D><C><H><A><L>
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.<BOP>
Q9BW91
Q9UGI9
AAKG3_HUMAN
5'-AMP-activated protein kinase subunit gamma-3
Homo
<M><E><P><G><L><E><H><A><L><R><R><T><P><S><W><S><S><L><G><G><S><E><H><Q><E><M><S><F><L><E><Q><E><N><S><S><S><W><P><S><P><A><V><T><S><S><S><E><R><I><R><G><K><R><R><A><K><A><L><R><W><T><R><Q><K><S><V><E><E><G><E><P><P><G><Q><G><E><G><P><R><S><R><P><A><A><E><S><T><G><L><E><A><T><F><P><K><T><T><P><L><A><Q><A><D><P><A><G><V><G><T><P><P><T><G><W><D><C><L><P><S><D><C><T><A><S><A><A><G><S><S><T><D><D><V><E><L><A><T><E><F><P><A><T><E><A><W><E><C><E><L><E><G><L><L><E><E><R><P><A><L><C><L><S><P><Q><A><P><F><P><K><L><G><W><D><D><E><L><R><K><P><G><A><Q><I><Y><M><R><F><M><Q><E><H><T><C><Y><D><A><M><A><T><S><S><K><L><V><I><F><D><T><M><L><E><I><K><K><A><F><F><A><L><V><A><N><G><V><R><A><A><P><L><W><D><S><K><K><Q><S><F><V><G><M><L><T><I><T><D><F><I><L><V><L><H><R><Y><Y><R><S><P><L><V><Q><I><Y><E><I><E><Q><H><K><I><E><T><W><R><E><I><Y><L><Q><G><C><F><K><P><L><V><S><I><S><P><N><D><S><L><F><E><A><V><Y><T><L><I><K><N><R><I><H><R><L><P><V><L><D><P><V><S><G><N><V><L><H><I><L><T><H><K><R><L><L><K><F><L><H><I><F><G><S><L><L><P><R><P><S><F><L><Y><R><T><I><Q><D><L><G><I><G><T><F><R><D><L><A><V><V><L><E><T><A><P><I><L><T><A><L><D><I><F><V><D><R><R><V><S><A><L><P><V><V><N><E><C><G><Q><V><V><G><L><Y><S><R><F><D><V><I><H><L><A><A><Q><Q><T><Y><N><H><L><D><M><S><V><G><E><A><L><R><Q><R><T><L><C><L><E><G><V><L><S><C><Q><P><H><E><S><L><G><E><V><I><D><R><I><A><R><E><Q><V><H><R><L><V><L><V><D><E><T><Q><H><L><L><G><V><V><S><L><S><D><I><L><Q><A><L><V><L><S><P><A><G><I><D><A><L><G><A>
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism . It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.<BOP>
Q9UGI9
Q96BA8
CR3L1_HUMAN
Processed cyclic AMP-responsive element-binding protein 3-like protein 1
Homo
<M><D><A><V><L><E><P><F><P><A><D><R><L><F><P><G><S><S><F><L><D><L><G><D><L><N><E><S><D><F><L><N><N><A><H><F><P><E><H><L><D><H><F><T><E><N><M><E><D><F><S><N><D><L><F><S><S><F><F><D><D><P><V><L><D><E><K><S><P><L><L><D><M><E><L><D><S><P><T><P><G><I><Q><A><E><H><S><Y><S><L><S><G><D><S><A><P><Q><S><P><L><V><P><I><K><M><E><D><T><T><Q><D><A><E><H><G><A><W><A><L><G><H><K><L><C><S><I><M><V><K><Q><E><Q><S><P><E><L><P><V><D><P><L><A><A><P><S><A><M><A><A><A><A><A><M><A><T><T><P><L><L><G><L><S><P><L><S><R><L><P><I><P><H><Q><A><P><G><E><M><T><Q><L><P><V><I><K><A><E><P><L><E><V><N><Q><F><L><K><V><T><P><E><D><L><V><Q><M><P><P><T><P><P><S><S><H><G><S><D><S><D><G><S><Q><S><P><R><S><L><P><P><S><S><P><V><R><P><M><A><R><S><S><T><A><I><S><T><S><P><L><L><T><A><P><H><K><L><Q><G><T><S><G><P><L><L><L><T><E><E><E><K><R><T><L><I><A><E><G><Y><P><I><P><T><K><L><P><L><T><K><A><E><E><K><A><L><K><R><V><R><R><K><I><K><N><K><I><S><A><Q><E><S><R><R><K><K><K><E><Y><V><E><C><L><E><K><K><V><E><T><F><T><S><E><N><N><E><L><W><K><K><V><E><T><L><E><N><A><N><R><T><L><L><Q><Q><L><Q><K><L><Q><T><L><V><T><N><K><I><S><R><P><Y><K><M><A><A><T><Q><T><G><T><C><L><M><V><A><A><L><C><F><V><L><V><L><G><S><L><V><P><C><L><P><E><F><S><S><G><S><Q><T><V><K><E><D><P><L><A><A><D><G><V><Y><T><A><S><Q><M><P><S><R><S><L><L><F><Y><D><D><G><A><G><L><W><E><D><G><R><S><T><L><L><P><M><E><P><P><D><G><W><E><I><N><P><G><G><P><A><E><Q><R><P><R><D><H><L><Q><H><D><H><L><D><S><T><H><E><T><T><K><Y><L><S><E><A><W><P><K><D><G><G><N><G><T><S><P><D><F><S><H><S><K><E><W><F><H><D><R><D><L><G><P><N><T><T><I><K><L><S>
(Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A .<BOP>
Q96BA8
Q96FX8
PERP_HUMAN
Transmembrane protein THW
Homo
<M><I><R><C><G><L><A><C><E><R><C><R><W><I><L><P><L><L><L><L><S><A><I><A><F><D><I><I><A><L><A><G><R><G><W><L><Q><S><S><D><H><G><Q><T><S><S><L><W><W><K><C><S><Q><E><G><G><G><S><G><S><Y><E><E><G><C><Q><S><L><M><E><Y><A><W><G><R><A><A><A><A><M><L><F><C><G><F><I><I><L><V><I><C><F><I><L><S><F><F><A><L><C><G><P><Q><M><L><V><F><L><R><V><I><G><G><L><L><A><L><A><A><V><F><Q><I><I><S><L><V><I><Y><P><V><K><Y><T><Q><T><F><T><L><H><A><N><P><A><V><T><Y><I><Y><N><W><A><Y><G><F><G><W><A><A><T><I><I><L><I><G><C><A><F><F><F><C><C><L><P><N><Y><E><D><D><L><L><G><N><A><K><P><R><Y><F><Y><T><S><A>
Plays a role as an effector in the TP53-dependent apoptotic pathway.<BOP>
Q96FX8
Q86VL8
S47A2_HUMAN
Solute carrier family 47 member 2
Homo
<M><D><S><L><Q><D><T><V><A><L><D><H><G><G><C><C><P><A><L><S><R><L><V><P><R><G><F><G><T><E><M><W><T><L><F><A><L><S><G><P><L><F><L><F><Q><V><L><T><F><M><I><Y><I><V><S><T><V><F><C><G><H><L><G><K><V><E><L><A><S><V><T><L><A><V><A><F><V><N><V><C><G><V><S><V><G><V><G><L><S><S><A><C><D><T><L><M><S><Q><S><F><G><S><P><N><K><K><H><V><G><V><I><L><Q><R><G><A><L><V><L><L><L><C><C><L><P><C><W><A><L><F><L><N><T><Q><H><I><L><L><L><F><R><Q><D><P><D><V><S><R><L><T><Q><D><Y><V><M><I><F><I><P><G><L><P><V><I><F><L><Y><N><L><L><A><K><Y><L><Q><N><Q><G><W><L><K><G><Q><E><E><E><S><P><F><Q><T><P><G><L><S><I><L><H><P><S><H><S><H><L><S><R><A><S><F><H><L><F><Q><K><I><T><W><P><Q><V><L><S><G><V><V><G><N><C><V><N><G><V><A><N><Y><A><L><V><S><V><L><N><L><G><V><R><G><S><A><Y><A><N><I><I><S><Q><F><A><Q><T><V><F><L><L><L><Y><I><V><L><K><K><L><H><L><E><T><W><A><G><W><S><S><Q><C><L><Q><D><W><G><P><F><F><S><L><A><V><P><S><M><L><M><I><C><V><E><W><W><A><Y><E><I><G><S><F><L><M><G><L><L><S><V><V><D><L><S><A><Q><A><V><I><Y><E><V><A><T><V><T><Y><M><I><P><L><G><L><S><I><G><V><C><V><R><V><G><M><A><L><G><A><A><D><T><V><Q><A><K><R><S><A><V><S><G><V><L><S><I><V><G><I><S><L><V><L><G><T><L><I><S><I><L><K><N><Q><L><G><H><I><F><T><N><D><E><D><V><I><A><L><V><S><Q><V><L><P><V><Y><S><V><F><H><V><F><E><A><I><C><C><V><Y><G><G><V><L><R><G><T><G><K><Q><A><F><G><A><A><V><N><A><I><T><Y><Y><I><I><G><L><P><L><G><I><L><L><T><F><V><V><R><M><R><I><M><G><L><W><L><G><M><L><A><C><V><F><L><A><T><A><A><F><V><A><Y><T><A><R><L><D><W><K><L><A><A><E><E><A><K><K><H><S><G><R><Q><Q><Q><Q><R><A><E><S><T><A><T><R><P><G><P><E><K><A><V><L><S><S><V><A><T><G><S><S><P><G><I><T><L><T><T><Y><S><R><S><E><C><H><V><D><F><F><R><T><P><E><E><A><H><A><L><S><A><P><T><S><R><L><S><V><K><Q><L><V><I><R><R><G><A><A><L><G><A><A><S><A><T><L><M><V><G><L><T><V><R><I><L><A><T><R><H>
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.<BOP>
Q86VL8
O60812
HNRC1_HUMAN
hnRNP core protein C-like 1
Homo
<M><A><S><N><V><T><N><K><M><D><P><H><S><M><N><S><R><V><F><I><G><N><L><N><T><L><V><V><K><K><S><D><V><E><A><I><F><S><K><Y><G><K><I><A><G><C><S><V><H><K><G><F><A><F><V><Q><Y><D><K><E><K><N><A><R><A><A><V><A><G><E><D><G><R><M><I><A><S><Q><V><V><D><I><N><L><A><A><E><P><K><V><N><R><G><N><A><G><V><K><R><S><A><A><E><M><Y><G><S><S><F><D><L><D><Y><G><F><Q><R><D><Y><Y><D><G><M><Y><S><F><P><A><R><V><P><P><P><P><P><I><A><L><A><V><V><P><S><K><R><Q><R><L><S><G><N><T><S><R><R><G><K><S><G><F><N><S><K><S><G><K><R><G><S><S><K><S><G><K><L><K><G><D><D><L><Q><A><I><K><Q><E><L><T><Q><I><K><Q><K><V><D><S><L><L><E><N><L><E><K><I><E><K><E><Q><S><K><Q><E><V><E><V><K><N><A><K><S><E><E><E><Q><S><S><S><S><M><K><K><D><E><T><H><V><K><M><E><S><E><G><G><A><E><D><S><A><E><E><G><D><P><L><D><D><D><V><N><E><D><Q><G><D><D><Q><L><E><L><I><K><D><D><E><K><E><A><E><E><G><E><D><D><R><D><S><T><N><G><Q><D><D><S>
May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.<BOP>
O60812
Q8NC60
NOA1_HUMAN
Nitric oxide-associated protein 1
Homo
<M><L><P><A><R><L><P><F><R><L><L><S><L><F><L><R><G><S><A><P><T><A><A><R><H><G><L><R><E><P><L><L><E><R><R><C><A><A><A><S><S><F><Q><H><S><S><S><L><G><R><E><L><P><Y><D><P><V><D><T><E><G><F><G><E><G><G><D><M><Q><E><R><F><L><F><P><E><Y><I><L><D><P><E><P><Q><P><T><R><E><K><Q><L><Q><E><L><Q><Q><Q><Q><E><E><E><E><R><Q><R><Q><Q><R><R><E><E><R><R><Q><Q><N><L><R><A><R><S><R><E><H><P><V><V><G><H><P><D><P><A><L><P><P><S><G><V><N><C><S><G><C><G><A><E><L><H><C><Q><D><A><G><V><P><G><Y><L><P><R><E><K><F><L><R><T><A><E><A><D><G><G><L><A><R><T><V><C><Q><R><C><W><L><L><S><H><H><R><R><A><L><R><L><Q><V><S><R><E><Q><Y><L><E><L><V><S><A><A><L><R><R><P><G><P><S><L><V><L><Y><M><V><D><L><L><D><L><P><D><A><L><L><P><D><L><P><A><L><V><G><P><K><Q><L><I><V><L><G><N><K><V><D><L><L><P><Q><D><A><P><G><Y><R><Q><R><L><R><E><R><L><W><E><D><C><A><R><A><G><L><L><L><A><P><G><H><Q><G><P><Q><R><P><V><K><D><E><P><Q><D><G><E><N><P><N><P><P><N><W><S><R><T><V><V><R><D><V><R><L><I><S><A><K><T><G><Y><G><V><E><E><L><I><S><A><L><Q><R><S><W><R><Y><R><G><D><V><Y><L><V><G><A><T><N><A><G><K><S><T><L><F><N><T><L><L><E><S><D><Y><C><T><A><K><G><S><E><A><I><D><R><A><T><I><S><P><W><P><G><T><T><L><N><L><L><K><F><P><I><C><N><P><T><P><Y><R><M><F><K><R><H><Q><R><L><K><K><D><S><T><Q><A><E><E><D><L><S><E><Q><E><Q><N><Q><L><N><V><L><K><K><H><G><Y><V><V><G><R><V><G><R><T><F><L><Y><S><E><E><Q><K><D><N><I><P><F><E><F><D><A><D><S><L><A><F><D><M><E><N><D><P><V><M><G><T><H><K><S><T><K><Q><V><E><L><T><A><Q><D><V><K><D><A><H><W><F><Y><D><T><P><G><I><T><K><E><N><C><I><L><N><L><L><T><E><K><E><V><N><I><V><L><P><T><Q><S><I><V><P><R><T><F><V><L><K><P><G><M><V><L><F><L><G><A><I><G><R><I><D><F><L><Q><G><N><Q><S><A><W><F><T><V><V><A><S><N><I><L><P><V><H><I><T><S><L><D><R><A><D><A><L><Y><Q><K><H><A><G><H><T><L><L><Q><I><P><M><G><G><K><E><R><M><A><G><F><P><P><L><V><A><E><D><I><M><L><K><E><G><L><G><A><S><E><A><V><A><D><I><K><F><S><S><A><G><W><V><S><V><T><P><N><F><K><D><R><L><H><L><R><G><Y><T><P><E><G><T><V><L><T><V><R><P><P><L><L><P><Y><I><V><N><I><K><G><Q><R><I><K><K><S><V><A><Y><K><T><K><K><P><P><S><L><M><Y><N><V><R><K><K><K><G><K><I><N><V>
Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.<BOP>
Q8NC60
Q92743
HTRA1_HUMAN
Serine protease 11
Homo
<M><Q><I><P><R><A><A><L><L><P><L><L><L><L><L><L><A><A><P><A><S><A><Q><L><S><R><A><G><R><S><A><P><L><A><A><G><C><P><D><R><C><E><P><A><R><C><P><P><Q><P><E><H><C><E><G><G><R><A><R><D><A><C><G><C><C><E><V><C><G><A><P><E><G><A><A><C><G><L><Q><E><G><P><C><G><E><G><L><Q><C><V><V><P><F><G><V><P><A><S><A><T><V><R><R><R><A><Q><A><G><L><C><V><C><A><S><S><E><P><V><C><G><S><D><A><N><T><Y><A><N><L><C><Q><L><R><A><A><S><R><R><S><E><R><L><H><R><P><P><V><I><V><L><Q><R><G><A><C><G><Q><G><Q><E><D><P><N><S><L><R><H><K><Y><N><F><I><A><D><V><V><E><K><I><A><P><A><V><V><H><I><E><L><F><R><K><L><P><F><S><K><R><E><V><P><V><A><S><G><S><G><F><I><V><S><E><D><G><L><I><V><T><N><A><H><V><V><T><N><K><H><R><V><K><V><E><L><K><N><G><A><T><Y><E><A><K><I><K><D><V><D><E><K><A><D><I><A><L><I><K><I><D><H><Q><G><K><L><P><V><L><L><L><G><R><S><S><E><L><R><P><G><E><F><V><V><A><I><G><S><P><F><S><L><Q><N><T><V><T><T><G><I><V><S><T><T><Q><R><G><G><K><E><L><G><L><R><N><S><D><M><D><Y><I><Q><T><D><A><I><I><N><Y><G><N><S><G><G><P><L><V><N><L><D><G><E><V><I><G><I><N><T><L><K><V><T><A><G><I><S><F><A><I><P><S><D><K><I><K><K><F><L><T><E><S><H><D><R><Q><A><K><G><K><A><I><T><K><K><K><Y><I><G><I><R><M><M><S><L><T><S><S><K><A><K><E><L><K><D><R><H><R><D><F><P><D><V><I><S><G><A><Y><I><I><E><V><I><P><D><T><P><A><E><A><G><G><L><K><E><N><D><V><I><I><S><I><N><G><Q><S><V><V><S><A><N><D><V><S><D><V><I><K><R><E><S><T><L><N><M><V><V><R><R><G><N><E><D><I><M><I><T><V><I><P><E><E><I><D><P>
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.<BOP>
Q92743
O75829
CNMD_HUMAN
Chondromodulin-I
Homo
<M><T><E><N><S><D><K><V><P><I><A><L><V><G><P><D><D><V><E><F><C><S><P><P><A><Y><A><T><L><T><V><K><P><S><S><P><A><R><L><L><K><V><G><A><V><V><L><I><S><G><A><V><L><L><L><F><G><A><I><G><A><F><Y><F><W><K><G><S><D><S><H><I><Y><N><V><H><Y><T><M><S><I><N><G><K><L><Q><D><G><S><M><E><I><D><A><G><N><N><L><E><T><F><K><M><G><S><G><A><E><E><A><I><A><V><N><D><F><Q><N><G><I><T><G><I><R><F><A><G><G><E><K><C><Y><I><K><A><Q><V><K><A><R><I><P><E><V><G><A><V><T><K><Q><S><I><S><S><K><L><E><G><K><I><M><P><V><K><Y><E><E><N><S><L><I><W><V><A><V><D><Q><P><V><K><D><N><S><F><L><S><S><K><V><L><E><L><C><G><D><L><P><I><F><W><L><K><P><T><Y><P><K><E><I><Q><R><E><R><R><E><V><V><R><K><I><V><P><T><T><T><K><R><P><H><S><G><P><R><S><N><P><G><A><G><R><L><N><N><E><T><R><P><S><V><Q><E><D><S><Q><A><F><N><P><D><N><P><Y><H><Q><Q><E><G><E><S><M><T><F><D><P><R><L><D><H><E><G><I><C><C><I><E><C><R><R><S><Y><T><H><C><Q><K><I><C><E><P><L><G><G><Y><Y><P><W><P><Y><N><Y><Q><G><C><R><S><A><C><R><V><I><M><P><C><S><W><W><V><A><R><I><L><G><M><V>
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.<BOP>
O75829
Q96D98
EID2B_HUMAN
EID-2-like inhibitor of differentiation 3
Homo
<M><A><E><P><T><G><L><L><E><M><S><E><L><P><G><D><S><S><V><P><Q><V><G><T><A><S><G><V><S><D><V><L><R><G><A><V><G><G><G><V><R><V><Q><E><A><R><E><G><P><V><A><E><A><A><R><S><M><A><R><M><P><G><P><V><P><G><P><I><P><S><S><V><P><G><L><A><S><A><P><D><P><H><Q><Q><L><A><F><L><E><I><N><R><Q><L><L><F><R><E><Y><L><D><G><S><S><M><I><P><V><R><L><L><R><D><F><E><E><R><R><R><L><F><V><E><G><C><K><A><R><E><A><A><F><D><A><D><P><P><Q><M><D><F><A><A><V><A><F><T><V><A><L><T><A><S><E><A><L><S><P><L><A><D>
Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.<BOP>
Q96D98
Q86TP1
PRUN1_HUMAN
Protein prune homolog 1
Homo
<M><E><D><Y><L><Q><G><C><R><A><A><L><Q><E><S><R><P><L><H><V><V><L><G><N><E><A><C><D><L><D><S><T><V><S><A><L><A><L><A><F><Y><L><A><K><T><T><E><A><E><E><V><F><V><P><V><L><N><I><K><R><S><E><L><P><L><R><G><D><I><V><F><F><L><Q><K><V><H><I><P><E><S><I><L><I><F><R><D><E><I><D><L><H><A><L><Y><Q><A><G><Q><L><T><L><I><L><V><D><H><H><I><L><S><K><S><D><T><A><L><E><E><A><V><A><E><V><L><D><H><R><P><I><E><P><K><H><C><P><P><C><H><V><S><V><E><L><V><G><S><C><A><T><L><V><T><E><R><I><L><Q><G><A><P><E><I><L><D><R><Q><T><A><A><L><L><H><G><T><I><I><L><D><C><V><N><M><D><L><K><I><G><K><A><T><P><K><D><S><K><Y><V><E><K><L><E><A><L><F><P><D><L><P><K><R><N><D><I><F><D><S><L><Q><K><A><K><F><D><V><S><G><L><T><T><E><Q><M><L><R><K><D><Q><K><T><I><Y><R><Q><G><V><K><V><A><I><S><A><I><Y><M><D><L><E><A><F><L><Q><R><S><N><L><L><A><D><L><H><A><F><C><Q><A><H><S><Y><D><V><L><V><A><M><T><I><F><F><N><T><H><N><E><P><V><R><Q><L><A><I><F><C><P><H><V><A><L><Q><T><T><I><C><E><V><L><E><R><S><H><S><P><P><L><K><L><T><P><A><S><S><T><H><P><N><L><H><A><Y><L><Q><G><N><T><Q><V><S><R><K><K><L><L><P><L><L><Q><E><A><L><S><A><Y><F><D><S><M><K><I><P><S><G><Q><P><E><T><A><D><V><S><R><E><Q><V><D><K><E><L><D><R><A><S><N><S><L><I><S><G><L><S><Q><D><E><E><D><P><P><L><P><P><T><P><M><N><S><L><V><D><E><C><P><L><D><Q><G><L><P><K><L><S><A><E><A><V><F><E><K><C><S><Q><I><S><L><S><Q><S><T><T><A><S><L><S><K><K>
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis . Involved in the regulation of microtubule polymerization .<BOP>
Q86TP1
O14672
ADA10_HUMAN
Mammalian disintegrin-metalloprotease
Homo
<M><V><L><L><R><V><L><I><L><L><L><S><W><A><A><G><M><G><G><Q><Y><G><N><P><L><N><K><Y><I><R><H><Y><E><G><L><S><Y><N><V><D><S><L><H><Q><K><H><Q><R><A><K><R><A><V><S><H><E><D><Q><F><L><R><L><D><F><H><A><H><G><R><H><F><N><L><R><M><K><R><D><T><S><L><F><S><D><E><F><K><V><E><T><S><N><K><V><L><D><Y><D><T><S><H><I><Y><T><G><H><I><Y><G><E><E><G><S><F><S><H><G><S><V><I><D><G><R><F><E><G><F><I><Q><T><R><G><G><T><F><Y><V><E><P><A><E><R><Y><I><K><D><R><T><L><P><F><H><S><V><I><Y><H><E><D><D><I><N><Y><P><H><K><Y><G><P><Q><G><G><C><A><D><H><S><V><F><E><R><M><R><K><Y><Q><M><T><G><V><E><E><V><T><Q><I><P><Q><E><E><H><A><A><N><G><P><E><L><L><R><K><K><R><T><T><S><A><E><K><N><T><C><Q><L><Y><I><Q><T><D><H><L><F><F><K><Y><Y><G><T><R><E><A><V><I><A><Q><I><S><S><H><V><K><A><I><D><T><I><Y><Q><T><T><D><F><S><G><I><R><N><I><S><F><M><V><K><R><I><R><I><N><T><T><A><D><E><K><D><P><T><N><P><F><R><F><P><N><I><G><V><E><K><F><L><E><L><N><S><E><Q><N><H><D><D><Y><C><L><A><Y><V><F><T><D><R><D><F><D><D><G><V><L><G><L><A><W><V><G><A><P><S><G><S><S><G><G><I><C><E><K><S><K><L><Y><S><D><G><K><K><K><S><L><N><T><G><I><I><T><V><Q><N><Y><G><S><H><V><P><P><K><V><S><H><I><T><F><A><H><E><V><G><H><N><F><G><S><P><H><D><S><G><T><E><C><T><P><G><E><S><K><N><L><G><Q><K><E><N><G><N><Y><I><M><Y><A><R><A><T><S><G><D><K><L><N><N><N><K><F><S><L><C><S><I><R><N><I><S><Q><V><L><E><K><K><R><N><N><C><F><V><E><S><G><Q><P><I><C><G><N><G><M><V><E><Q><G><E><E><C><D><C><G><Y><S><D><Q><C><K><D><E><C><C><F><D><A><N><Q><P><E><G><R><K><C><K><L><K><P><G><K><Q><C><S><P><S><Q><G><P><C><C><T><A><Q><C><A><F><K><S><K><S><E><K><C><R><D><D><S><D><C><A><R><E><G><I><C><N><G><F><T><A><L><C><P><A><S><D><P><K><P><N><F><T><D><C><N><R><H><T><Q><V><C><I><N><G><Q><C><A><G><S><I><C><E><K><Y><G><L><E><E><C><T><C><A><S><S><D><G><K><D><D><K><E><L><C><H><V><C><C><M><K><K><M><D><P><S><T><C><A><S><T><G><S><V><Q><W><S><R><H><F><S><G><R><T><I><T><L><Q><P><G><S><P><C><N><D><F><R><G><Y><C><D><V><F><M><R><C><R><L><V><D><A><D><G><P><L><A><R><L><K><K><A><I><F><S><P><E><L><Y><E><N><I><A><E><W><I><V><A><H><W><W><A><V><L><L><M><G><I><A><L><I><M><L><M><A><G><F><I><K><I><C><S><V><H><T><P><S><S><N><P><K><L><P><P><P><K><P><L><P><G><T><L><K><R><R><R><P><P><Q><P><I><Q><Q><P><Q><R><Q><R><P><R><E><S><Y><Q><M><G><H><M><R><R>
(Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores.<BOP>
O14672
Q8WXH5
SOCS4_HUMAN
Suppressor of cytokine signaling 7
Homo
<M><A><E><N><N><E><N><I><S><K><N><V><D><V><R><P><K><T><S><R><S><R><S><A><D><R><K><D><G><Y><V><W><S><G><K><K><L><S><W><S><K><K><S><E><S><Y><S><D><A><E><T><V><N><G><I><E><K><T><E><V><S><L><R><N><Q><E><R><K><H><S><C><S><S><I><E><L><D><L><D><H><S><C><G><H><R><F><L><G><R><S><L><K><Q><K><L><Q><D><A><V><G><Q><C><F><P><I><K><N><C><S><S><R><H><S><S><G><L><P><S><K><R><K><I><H><I><S><E><L><M><L><D><K><C><P><F><P><P><R><S><D><L><A><F><R><W><H><F><I><K><R><H><T><A><P><I><N><S><K><S><D><E><W><V><S><T><D><L><S><Q><T><E><L><R><D><G><Q><L><K><R><R><N><M><E><E><N><I><N><C><F><S><H><T><N><V><Q><P><C><V><I><T><T><D><N><A><L><C><R><E><G><P><M><T><G><S><V><M><N><L><V><S><N><N><S><I><E><D><S><D><M><D><S><D><D><E><I><L><T><L><C><T><S><S><R><K><R><N><K><P><K><W><D><L><D><D><E><I><L><Q><L><E><T><P><P><K><Y><H><T><Q><I><D><Y><V><H><C><L><V><P><D><L><L><Q><I><N><N><N><P><C><Y><W><G><V><M><D><K><Y><A><A><E><A><L><L><E><G><K><P><E><G><T><F><L><L><R><D><S><A><Q><E><D><Y><L><F><S><V><S><F><R><R><Y><S><R><S><L><H><A><R><I><E><Q><W><N><H><N><F><S><F><D><A><H><D><P><C><V><F><H><S><P><D><I><T><G><L><L><E><H><Y><K><D><P><S><A><C><M><F><F><E><P><L><L><S><T><P><L><I><R><T><F><P><F><S><L><Q><H><I><C><R><T><V><I><C><N><C><T><T><Y><D><G><I><D><A><L><P><I><P><S><S><M><K><L><Y><L><K><E><Y><H><Y><K><S><K><V><R><V><L><R><I><D><A><P><E><Q><Q><C>
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.<BOP>
Q8WXH5
A8K010
CF176_HUMAN
Putative transcriptional regulator encoded by LINC00473
Homo
<M><E><L><S><A><A><A><G><R><R><R><Q><A><P><W><R><E><F><T><G><R><H><R><T><E><R><S><Q><E><R><G><S><T><P><R><K><E><R><S><M><G><S><R><Q><P><R><K><R><E><R><E><P><R><D><C><T><P><T><C><T><N><A><A><S><V><S><R><S><G><A><R><R><A><P><G><C><A><G><R><C><I><T><M><K><N><C><A><R><A><W><R><E><L><S><E><R><A><C><C><F><Q><A><V><P><P><S><N><M><K><Q><S><W><L><I><F><L><D><T><T><L><C><S><A><W><L><L><A><S><S><C><P><R><L><Y><A><P><L><I><S><F><H><C><M><C><F><N><T><V><L><L><F><P><R><L><F><G><P><T><L><S><A><K><I><Q><F><N><T><D><L><S><L><R><A><I><A><W><K><C><T><K><D><T><T><T><Y><C>
May play a role in cAMP-mediated gene transcription.<BOP>
A8K010
Q9UHC7
MKRN1_HUMAN
RING-type E3 ubiquitin transferase makorin-1
Homo
<M><A><E><A><A><T><P><G><T><T><A><T><T><S><G><A><G><A><A><A><A><T><A><A><A><A><S><P><T><P><I><P><T><V><T><A><P><S><L><G><A><G><G><G><G><G><G><S><D><G><S><G><G><G><W><T><K><Q><V><T><C><R><Y><F><M><H><G><V><C><K><E><G><D><N><C><R><Y><S><H><D><L><S><D><S><P><Y><S><V><V><C><K><Y><F><Q><R><G><Y><C><I><Y><G><D><R><C><R><Y><E><H><S><K><P><L><K><Q><E><E><A><T><A><T><E><L><T><T><K><S><S><L><A><A><S><S><S><L><S><S><I><V><G><P><L><V><E><M><N><T><G><E><A><E><S><R><N><S><N><F><A><T><V><G><A><G><S><E><D><W><V><N><A><I><E><F><V><P><G><Q><P><Y><C><G><R><T><A><P><S><C><T><E><A><P><L><Q><G><S><V><T><K><E><E><S><E><K><E><Q><T><A><V><E><T><K><K><Q><L><C><P><Y><A><A><V><G><E><C><R><Y><G><E><N><C><V><Y><L><H><G><D><S><C><D><M><C><G><L><Q><V><L><H><P><M><D><A><A><Q><R><S><Q><H><I><K><S><C><I><E><A><H><E><K><D><M><E><L><S><F><A><V><Q><R><S><K><D><M><V><C><G><I><C><M><E><V><V><Y><E><K><A><N><P><S><E><R><R><F><G><I><L><S><N><C><N><H><T><Y><C><L><K><C><I><R><K><W><R><S><A><K><Q><F><E><S><K><I><I><K><S><C><P><E><C><R><I><T><S><N><F><V><I><P><S><E><Y><W><V><E><E><K><E><E><K><Q><K><L><I><L><K><Y><K><E><A><M><S><N><K><A><C><R><Y><F><D><E><G><R><G><S><C><P><F><G><G><N><C><F><Y><K><H><A><Y><P><D><G><R><R><E><E><P><Q><R><Q><K><V><G><T><S><S><R><Y><R><A><Q><R><R><N><H><F><W><E><L><I><E><E><R><E><N><S><N><P><F><D><N><D><E><E><E><V><V><T><F><E><L><G><E><M><L><L><M><L><L><A><A><G><G><D><D><E><L><T><D><S><E><D><E><W><D><L><F><H><D><E><L><E><D><F><Y><D><L><D><L>
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.<BOP>
Q9UHC7
Q9UJX2
CDC23_HUMAN
Cyclosome subunit 8
Homo
<M><A><A><S><T><S><M><V><P><V><A><V><T><A><A><V><A><P><V><L><S><I><N><S><D><F><S><D><L><R><E><I><K><K><Q><L><L><L><I><A><G><L><T><R><E><R><G><L><L><H><S><S><K><W><S><A><E><L><A><F><S><L><P><A><L><P><L><A><E><L><Q><P><P><P><P><I><T><E><E><D><A><Q><D><M><D><A><Y><T><L><A><K><A><Y><F><D><V><K><E><Y><D><R><A><A><H><F><L><H><G><C><N><S><K><K><A><Y><F><L><Y><M><Y><S><R><Y><L><S><G><E><K><K><K><D><D><E><T><V><D><S><L><G><P><L><E><K><G><Q><V><K><N><E><A><L><R><E><L><R><V><E><L><S><K><K><H><Q><A><R><E><L><D><G><F><G><L><Y><L><Y><G><V><V><L><R><K><L><D><L><V><K><E><A><I><D><V><F><V><E><A><T><H><V><L><P><L><H><W><G><A><W><L><E><L><C><N><L><I><T><D><K><E><M><L><K><F><L><S><L><P><D><T><W><M><K><E><F><F><L><A><H><I><Y><T><E><L><Q><L><I><E><E><A><L><Q><K><Y><Q><N><L><I><D><V><G><F><S><K><S><S><Y><I><V><S><Q><I><A><V><A><Y><H><N><I><R><D><I><D><K><A><L><S><I><F><N><E><L><R><K><Q><D><P><Y><R><I><E><N><M><D><T><F><S><N><L><L><Y><V><R><S><M><K><S><E><L><S><Y><L><A><H><N><L><C><E><I><D><K><Y><R><V><E><T><C><C><V><I><G><N><Y><Y><S><L><R><S><Q><H><E><K><A><A><L><Y><F><Q><R><A><L><K><L><N><P><R><Y><L><G><A><W><T><L><M><G><H><E><Y><M><E><M><K><N><T><S><A><A><I><Q><A><Y><R><H><A><I><E><V><N><K><R><D><Y><R><A><W><Y><G><L><G><Q><T><Y><E><I><L><K><M><P><F><Y><C><L><Y><Y><Y><R><R><A><H><Q><L><R><P><N><D><S><R><M><L><V><A><L><G><E><C><Y><E><K><L><N><Q><L><V><E><A><K><K><C><Y><W><R><A><Y><A><V><G><D><V><E><K><M><A><L><V><K><L><A><K><L><H><E><Q><L><T><E><S><E><Q><A><A><Q><C><Y><I><K><Y><I><Q><D><I><Y><S><C><G><E><I><V><E><H><L><E><E><S><T><A><F><R><Y><L><A><Q><Y><Y><F><K><C><K><L><W><D><E><A><S><T><C><A><Q><K><C><C><A><F><N><D><T><R><E><E><G><K><A><L><L><R><Q><I><L><Q><L><R><N><Q><G><E><T><P><T><T><E><V><P><A><P><F><F><L><P><A><S><L><S><A><N><N><T><P><T><R><R><V><S><P><L><N><L><S><S><V><T><P>
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<BOP>
Q9UJX2
Q6PIU1
KCNV1_HUMAN
Voltage-gated potassium channel subunit Kv8.1
Homo
<M><P><S><S><G><R><A><L><L><D><S><P><L><D><S><G><S><L><T><S><L><D><S><S><V><F><C><S><E><G><E><G><E><P><L><A><L><G><D><C><F><T><V><N><V><G><G><S><R><F><V><L><S><Q><Q><A><L><S><C><F><P><H><T><R><L><G><K><L><A><V><V><V><A><S><Y><R><R><P><G><A><L><A><A><V><P><S><P><L><E><L><C><D><D><A><N><P><V><D><N><E><Y><F><F><D><R><S><S><Q><A><F><R><Y><V><L><H><Y><Y><R><T><G><R><L><H><V><M><E><Q><L><C><A><L><S><F><L><Q><E><I><Q><Y><W><G><I><D><E><L><S><I><D><S><C><C><R><D><R><Y><F><R><R><K><E><L><S><E><T><L><D><F><K><K><D><T><E><D><Q><E><S><Q><H><E><S><E><Q><D><F><S><Q><G><P><C><P><T><V><R><Q><K><L><W><N><I><L><E><K><P><G><S><S><T><A><A><R><I><F><G><V><I><S><I><I><F><V><V><V><S><I><I><N><M><A><L><M><S><A><E><L><S><W><L><D><L><Q><L><L><E><I><L><E><Y><V><C><I><S><W><F><T><G><E><F><V><L><R><F><L><C><V><R><D><R><C><R><F><L><R><K><V><P><N><I><I><D><L><L><A><I><L><P><F><Y><I><T><L><L><V><E><S><L><S><G><S><Q><T><T><Q><E><L><E><N><V><G><R><I><V><Q><V><L><R><L><L><R><A><L><R><M><L><K><L><G><R><H><S><T><G><L><R><S><L><G><M><T><I><T><Q><C><Y><E><E><V><G><L><L><L><L><F><L><S><V><G><I><S><I><F><S><T><V><E><Y><F><A><E><Q><S><I><P><D><T><T><F><T><S><V><P><C><A><W><W><W><A><T><T><S><M><T><T><V><G><Y><G><D><I><R><P><D><T><T><T><G><K><I><V><A><F><M><C><I><L><S><G><I><L><V><L><A><L><P><I><A><I><I><N><D><R><F><S><A><C><Y><F><T><L><K><L><K><E><A><A><V><R><Q><R><E><A><L><K><K><L><T><K><N><I><A><T><D><S><Y><I><S><V><N><L><R><D><V><Y><A><R><S><I><M><E><M><L><R><L><K><G><R><E><R><A><S><T><R><S><S><G><G><D><D><F><W><F>
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.<BOP>
Q6PIU1
O60269
GRIN2_HUMAN
G protein-regulated inducer of neurite outgrowth 2
Homo
<M><S><S><S><R><P><E><P><G><P><W><A><P><L><S><P><R><L><Q><P><L><S><Q><S><S><S><S><L><L><G><E><G><R><E><Q><R><P><E><L><R><K><T><A><S><S><T><V><W><Q><A><Q><L><G><E><A><S><T><R><P><Q><A><P><E><E><E><G><N><P><P><E><S><M><K><P><A><R><A><S><G><P><K><A><R><P><S><A><G><G><H><W><W><S><S><T><V><G><N><V><S><T><M><G><G><S><D><L><C><R><L><R><A><P><S><A><A><A><M><Q><R><S><H><S><D><L><V><R><S><T><Q><M><R><G><H><S><G><A><R><K><A><S><L><S><C><S><A><L><G><S><S><P><V><H><R><A><Q><L><Q><P><G><G><T><S><G><Q><G><G><Q><A><P><A><G><L><E><R><D><L><A><P><E><D><E><T><S><N><S><A><W><M><L><G><A><S><Q><L><S><V><P><P><L><D><L><G><D><T><T><A><H><S><S><S><A><Q><A><E><P><K><A><A><E><Q><L><A><T><T><T><C><H><A><L><P><P><A><A><L><L><C><G><M><R><E><V><R><A><G><G><C><C><H><A><L><P><A><T><G><I><L><A><F><P><K><L><V><A><S><V><S><E><S><G><L><Q><A><Q><H><G><V><K><I><H><C><R><L><S><G><G><L><P><G><H><S><H><C><C><A><H><L><W><G><P><A><G><L><V><P><E><P><G><S><R><T><K><D><V><W><T><M><T><S><A><N><D><L><A><P><A><E><A><S><P><L><S><A><Q><D><A><G><V><Q><A><A><P><V><A><A><C><K><A><V><A><T><S><P><S><L><E><A><P><A><A><L><H><V><F><P><E><V><T><L><G><S><S><L><E><E><V><P><S><P><V><R><D><V><R><W><D><A><E><G><M><T><W><E><V><Y><G><A><A><V><D><L><E><V><L><G><V><A><I><Q><K><H><L><E><M><Q><F><E><Q><L><Q><R><A><P><A><S><E><D><S><L><S><V><E><G><R><R><G><P><L><R><A><V><M><Q><S><L><R><R><P><S><C><C><G><C><S><G><A><A><P><E>
May be involved in neurite outgrowth.<BOP>
O60269
Q6L8Q7
PDE12_HUMAN
Mitochondrial deadenylase
Homo
<M><W><R><L><P><G><A><R><A><A><L><R><V><I><R><T><A><V><E><K><L><S><R><A><E><A><G><S><Q><T><A><A><G><A><M><E><R><A><V><V><R><C><V><P><S><E><P><K><L><S><L><S><F><A><L><A><D><G><S><H><K><N><M><Q><R><D><Q><S><E><P><L><G><R><V><L><S><R><I><A><T><N><A><L><K><G><H><A><K><A><A><A><A><K><K><S><R><K><S><R><P><N><A><S><G><G><A><A><C><S><G><P><G><P><E><P><A><V><F><C><E><P><V><V><K><L><Y><Y><R><E><E><A><V><A><E><D><V><L><N><V><D><A><W><Q><D><G><A><V><L><Q><I><G><D><V><K><Y><K><V><E><R><N><P><P><A><F><T><E><L><Q><L><P><R><Y><I><M><A><G><F><P><V><C><P><K><L><S><L><E><F><G><D><P><A><S><S><L><F><R><W><Y><K><E><A><K><P><G><A><A><E><P><E><V><G><V><P><S><S><L><S><P><S><S><P><S><S><S><W><T><E><T><D><V><E><E><R><V><Y><T><P><S><N><A><D><I><G><L><R><L><K><L><H><C><T><P><G><D><G><Q><R><F><G><H><S><R><E><L><E><S><V><C><V><V><E><A><G><P><G><T><C><T><F><D><H><R><H><L><Y><T><K><K><V><T><E><D><A><L><I><R><T><V><S><Y><N><I><L><A><D><T><Y><A><Q><T><E><F><S><R><T><V><L><Y><P><Y><C><A><P><Y><A><L><E><L><D><Y><R><Q><N><L><I><Q><K><E><L><T><G><Y><N><A><D><V><I><C><L><Q><E><V><D><R><A><V><F><S><D><S><L><V><P><A><L><E><A><F><G><L><E><G><V><F><R><I><K><Q><H><E><G><L><A><T><F><Y><R><K><S><K><F><S><L><L><S><Q><H><D><I><S><F><Y><E><A><L><E><S><D><P><L><H><K><E><L><L><E><K><L><V><L><Y><P><S><A><Q><E><K><V><L><Q><R><S><S><V><L><Q><V><S><V><L><Q><S><T><K><D><S><S><K><R><I><C><V><A><N><T><H><L><Y><W><H><P><K><G><G><Y><I><R><L><I><Q><M><A><V><A><L><A><H><I><R><H><V><S><C><D><L><Y><P><G><I><P><V><I><F><C><G><D><F><N><S><T><P><S><T><G><M><Y><H><F><V><I><N><G><S><I><P><E><D><H><E><D><W><A><S><N><G><E><E><E><R><C><N><M><S><L><T><H><F><F><K><L><K><S><A><C><G><E><P><A><Y><T><N><Y><V><G><G><F><H><G><C><L><D><Y><I><F><I><D><L><N><A><L><E><V><E><Q><V><I><P><L><P><S><H><E><E><V><T><T><H><Q><A><L><P><S><V><S><H><P><S><D><H><I><A><L><V><C><D><L><K><W><K>
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP . Also cleaves 3',5'-phosphodiester bond of oligoadenylates . Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells .<BOP>
Q6L8Q7
Q6PJ61
FBX46_HUMAN
F-box only protein 34-like
Homo
<M><D><R><G><S><L><L><P><F><Q><L><W><C><P><R><P><F><G><T><Y><S><Q><N><Q><P><R><P><P><S><A><A><L><K><P><S><A><C><P><E><P><G><G><G><A><E><P><D><H><G><P><A><H><S><E><N><T><P><P><A><L><A><T><E><V><P><A><S><Q><P><A><P><L><L><S><A><A><A><A><G><D><E><G><R><V><L><L><D><T><W><Y><V><I><K><P><G><N><T><K><E><K><V><A><F><F><V><A><H><Q><C><G><G><G><S><R><A><S><S><M><K><V><K><G><H><W><G><S><D><S><S><K><A><K><R><R><R><R><C><L><D><P><T><K><A><P><P><D><P><G><G><R><E><G><P><P><A><A><E><E><G><P><A><S><A><G><E><D><V><D><L><L><S><V><A><E><M><V><A><L><V><E><Q><R><A><A><L><A><L><Q><S><Y><P><R><P><T><T><P><A><P><V><V><F><V><S><A><E><Q><G><G><P><A><K><G><V><G><S><E><R><R><S><G><G><G><D><C><S><R><V><A><E><A><V><A><H><F><E><A><Q><R><D><S><P><P><T><K><G><L><R><K><E><E><R><P><G><P><G><P><G><E><V><R><I><A><F><R><I><S><N><G><R><E><P><R><A><P><D><S><G><L><P><S><G><G><G><G><R><P><G><C><A><Y><P><G><S><P><G><P><G><A><R><A><K><D><K><I><T><C><D><L><Y><Q><L><I><S><P><S><R><D><A><L><P><S><N><V><E><F><L><L><A><R><A><D><E><A><S><E><G><D><S><P><A><P><A><R><P><E><D><T><P><P><A><P><P><P><P><P><A><R><D><C><G><A><S><G><F><H><V><D><V><V><V><T><G><V><V><D><E><C><I><F><F><G><K><D><G><T><K><N><V><K><E><E><T><V><C><L><T><V><S><P><E><E><P><P><P><P><G><Q><L><F><F><L><Q><N><R><G><P><D><G><P><P><E><P><P><P><A><D><S><P><A><T><A><P><G><P><D><D><A><E><G><T><A><D><T><S><L><C><R><L><Y><R><H><V><S><H><D><F><L><E><I><R><F><K><I><Q><R><L><L><E><P><R><Q><Y><M><L><L><L><P><E><H><V><L><V><K><I><F><S><F><L><P><T><R><A><L><A><A><L><K><C><T><C><H><H><F><K><G><I><I><E><A><F><G><V><R><A><T><D><S><R><W><S><R><D><P><L><Y><R><D><D><P><C><K><Q><C><R><K><R><Y><E><K><G><D><V><S><L><C><R><W><H><P><K><P><Y><H><H><D><L><P><Y><G><R><S><Y><W><M><C><C><R><R><A><D><R><E><T><P><G><C><R><L><G><L><H><D><N><N><W><V><L><P><C><N><G><P><G><G><G><R><A><G><R><E><E><G><R>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
Q6PJ61
Q8TB40
ABHD4_HUMAN
Alpha/beta-hydrolase 4
Homo
<M><A><D><D><L><E><Q><Q><S><Q><G><W><L><S><S><W><L><P><T><W><R><P><T><S><M><S><Q><L><K><N><V><E><A><R><I><L><Q><C><L><Q><N><K><F><L><A><R><Y><V><S><L><P><N><Q><N><K><I><W><T><V><T><V><S><P><E><Q><N><D><R><T><P><L><V><M><V><H><G><F><G><G><G><V><G><L><W><I><L><N><M><D><S><L><S><A><R><R><T><L><H><T><F><D><L><L><G><F><G><R><S><S><R><P><A><F><P><R><D><P><E><G><A><E><D><E><F><V><T><S><I><E><T><W><R><E><T><M><G><I><P><S><M><I><L><L><G><H><S><L><G><G><F><L><A><T><S><Y><S><I><K><Y><P><D><R><V><K><H><L><I><L><V><D><P><W><G><F><P><L><R><P><T><N><P><S><E><I><R><A><P><P><A><W><V><K><A><V><A><S><V><L><G><R><S><N><P><L><A><V><L><R><V><A><G><P><W><G><P><G><L><V><Q><R><F><R><P><D><F><K><R><K><F><A><D><F><F><E><D><D><T><I><S><E><Y><I><Y><H><C><N><A><Q><N><P><S><G><E><T><A><F><K><A><M><M><E><S><F><G><W><A><R><R><P><M><L><E><R><I><H><L><I><R><K><D><V><P><I><T><M><I><Y><G><S><D><T><W><I><D><T><S><T><G><K><K><V><K><M><Q><R><P><D><S><Y><V><R><D><M><E><I><K><G><A><S><H><H><V><Y><A><D><Q><P><H><I><F><N><A><V><V><E><E><I><C><D><S><V><D>
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.<BOP>
Q8TB40
P20340
RAB6A_HUMAN
Ras-related protein Rab-6A
Homo
<M><S><T><G><G><D><F><G><N><P><L><R><K><F><K><L><V><F><L><G><E><Q><S><V><G><K><T><S><L><I><T><R><F><M><Y><D><S><F><D><N><T><Y><Q><A><T><I><G><I><D><F><L><S><K><T><M><Y><L><E><D><R><T><V><R><L><Q><L><W><D><T><A><G><Q><E><R><F><R><S><L><I><P><S><Y><I><R><D><S><T><V><A><V><V><V><Y><D><I><T><N><V><N><S><F><Q><Q><T><T><K><W><I><D><D><V><R><T><E><R><G><S><D><V><I><I><M><L><V><G><N><K><T><D><L><A><D><K><R><Q><V><S><I><E><E><G><E><R><K><A><K><E><L><N><V><M><F><I><E><T><S><A><K><A><G><Y><N><V><K><Q><L><F><R><R><V><A><A><A><L><P><G><M><E><S><T><Q><D><R><S><R><E><D><M><I><D><I><K><L><E><K><P><Q><E><Q><P><V><S><E><G><G><C><S><C>
Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) . Has a low GTPase activity . Recruits VPS13B to the Golgi membrane . Plays a role in neuron projection development (Probable).<BOP>
P20340
P15151
PVR_HUMAN
Nectin-like protein 5
Homo
<M><A><R><A><M><A><A><A><W><P><L><L><L><V><A><L><L><V><L><S><W><P><P><P><G><T><G><D><V><V><V><Q><A><P><T><Q><V><P><G><F><L><G><D><S><V><T><L><P><C><Y><L><Q><V><P><N><M><E><V><T><H><V><S><Q><L><T><W><A><R><H><G><E><S><G><S><M><A><V><F><H><Q><T><Q><G><P><S><Y><S><E><S><K><R><L><E><F><V><A><A><R><L><G><A><E><L><R><N><A><S><L><R><M><F><G><L><R><V><E><D><E><G><N><Y><T><C><L><F><V><T><F><P><Q><G><S><R><S><V><D><I><W><L><R><V><L><A><K><P><Q><N><T><A><E><V><Q><K><V><Q><L><T><G><E><P><V><P><M><A><R><C><V><S><T><G><G><R><P><P><A><Q><I><T><W><H><S><D><L><G><G><M><P><N><T><S><Q><V><P><G><F><L><S><G><T><V><T><V><T><S><L><W><I><L><V><P><S><S><Q><V><D><G><K><N><V><T><C><K><V><E><H><E><S><F><E><K><P><Q><L><L><T><V><N><L><T><V><Y><Y><P><P><E><V><S><I><S><G><Y><D><N><N><W><Y><L><G><Q><N><E><A><T><L><T><C><D><A><R><S><N><P><E><P><T><G><Y><N><W><S><T><T><M><G><P><L><P><P><F><A><V><A><Q><G><A><Q><L><L><I><R><P><V><D><K><P><I><N><T><T><L><I><C><N><V><T><N><A><L><G><A><R><Q><A><E><L><T><V><Q><V><K><E><G><P><P><S><E><H><S><G><I><S><R><N><A><I><I><F><L><V><L><G><I><L><V><F><L><I><L><L><G><I><G><I><Y><F><Y><W><S><K><C><S><R><E><V><L><W><H><C><H><L><C><P><S><S><T><E><H><A><S><A><S><A><N><G><H><V><S><Y><S><A><V><S><R><E><N><S><S><S><Q><D><P><Q><T><E><G><T><R>
(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.<BOP>
P15151
Q9Y2C4
EXOG_HUMAN
Endonuclease G-like 1
Homo
<M><A><I><K><S><I><A><S><R><L><R><G><S><R><R><F><L><S><G><F><V><A><G><A><V><V><G><A><A><G><A><G><L><A><A><L><Q><F><F><R><S><Q><G><A><E><G><A><L><T><G><K><Q><P><D><G><S><A><E><K><A><V><L><E><Q><F><G><F><P><L><T><G><T><E><A><R><C><Y><T><N><H><A><L><S><Y><D><Q><A><K><R><V><P><R><W><V><L><E><H><I><S><K><S><K><I><M><G><D><A><D><R><K><H><C><K><F><K><P><D><P><N><I><P><P><T><F><S><A><F><N><E><D><Y><V><G><S><G><W><S><R><G><H><M><A><P><A><G><N><N><K><F><S><S><K><A><M><A><E><T><F><Y><L><S><N><I><V><P><Q><D><F><D><N><N><S><G><Y><W><N><R><I><E><M><Y><C><R><E><L><T><E><R><F><E><D><V><W><V><V><S><G><P><L><T><L><P><Q><T><R><G><D><G><K><K><I><V><S><Y><Q><V><I><G><E><D><N><V><A><V><P><S><H><L><Y><K><V><I><L><A><R><R><S><S><V><S><T><E><P><L><A><L><G><A><F><V><V><P><N><E><A><I><G><F><Q><P><Q><L><T><E><F><Q><V><S><L><Q><D><L><E><K><L><S><G><L><V><F><F><P><H><L><D><R><T><S><D><I><R><N><I><C><S><V><D><T><C><K><L><L><D><F><Q><E><F><T><L><Y><L><S><T><R><K><I><E><G><A><R><S><V><L><R><L><E><K><I><M><E><N><L><K><N><A><E><I><E><P><D><D><Y><F><M><S><R><Y><E><K><K><L><E><E><L><K><A><K><E><Q><S><G><T><Q><I><R><K><P><S>
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.<BOP>
Q9Y2C4
Q53HC0
CCD92_HUMAN
Limkain beta-2
Homo
<M><T><S><P><H><F><S><S><Y><D><E><G><P><L><D><V><S><M><A><A><T><N><L><E><N><Q><L><H><S><A><Q><K><N><L><L><F><L><Q><R><E><H><A><S><T><L><K><G><L><H><S><E><I><R><R><L><Q><Q><H><C><T><D><L><T><Y><E><L><T><V><K><S><S><E><Q><T><G><D><G><T><S><K><S><S><E><L><K><K><R><C><E><E><L><E><A><Q><L><K><V><K><E><N><E><N><A><E><L><L><K><E><L><E><Q><K><N><A><M><I><T><V><L><E><N><T><I><K><E><R><E><K><K><Y><L><E><E><L><K><A><K><S><H><K><L><T><L><L><S><S><E><L><E><Q><R><A><S><T><I><A><Y><L><T><S><Q><L><H><A><A><K><K><K><L><M><S><S><S><G><T><S><D><A><S><P><S><G><S><P><V><L><A><S><Y><K><P><A><P><P><K><D><K><L><P><E><T><P><R><R><R><M><K><K><S><L><S><A><P><L><H><P><E><F><E><E><V><Y><R><F><G><A><E><S><R><K><L><L><L><R><E><P><V><D><A><M><P><D><P><T><P><F><L><L><A><R><E><S><A><E><V><H><L><I><K><E><R><P><L><V><I><P><P><I><A><S><D><R><S><G><E><Q><H><S><P><A><R><E><K><P><H><K><A><H><V><G><V><A><H><R><I><H><H><A><T><P><P><Q><A><Q><P><E><V><K><T><L><A><V><D><Q><V><N><G><G><K><V><V><R><K><H><S><G><T><D><R><T><V>
Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface.<BOP>
Q53HC0
Q9UHF5
IL17B_HUMAN
Neuronal interleukin-17-related factor
Homo
<M><D><W><P><H><N><L><L><F><L><L><T><I><S><I><F><L><G><L><G><Q><P><R><S><P><K><S><K><R><K><G><Q><G><R><P><G><P><L><A><P><G><P><H><Q><V><P><L><D><L><V><S><R><M><K><P><Y><A><R><M><E><E><Y><E><R><N><I><E><E><M><V><A><Q><L><R><N><S><S><E><L><A><Q><R><K><C><E><V><N><L><Q><L><W><M><S><N><K><R><S><L><S><P><W><G><Y><S><I><N><H><D><P><S><R><I><P><V><D><L><P><E><A><R><C><L><C><L><G><C><V><N><P><F><T><M><Q><E><D><R><S><M><V><S><V><P><V><F><S><Q><V><P><V><R><R><R><L><C><P><P><P><P><R><T><G><P><C><R><Q><R><A><V><M><E><T><I><A><V><G><C><T><C><I><F>
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.<BOP>
Q9UHF5
P0DJI9
SAA2_HUMAN
Amyloid A2 protein
Homo
<M><K><L><L><T><G><L><V><F><C><S><L><V><L><S><V><S><S><R><S><F><F><S><F><L><G><E><A><F><D><G><A><R><D><M><W><R><A><Y><S><D><M><R><E><A><N><Y><I><G><S><D><K><Y><F><H><A><R><G><N><Y><D><A><A><K><R><G><P><G><G><A><W><A><A><E><V><I><S><N><A><R><E><N><I><Q><R><L><T><G><R><G><A><E><D><S><L><A><D><Q><A><A><N><K><W><G><R><S><G><R><D><P><N><H><F><R><P><A><G><L><P><E><K><Y>
Major acute phase reactant.<BOP>
P0DJI9
Q9Y5N1
HRH3_HUMAN
G-protein coupled receptor 97
Homo
<M><E><R><A><P><P><D><G><P><L><N><A><S><G><A><L><A><G><E><A><A><A><A><G><G><A><R><G><F><S><A><A><W><T><A><V><L><A><A><L><M><A><L><L><I><V><A><T><V><L><G><N><A><L><V><M><L><A><F><V><A><D><S><S><L><R><T><Q><N><N><F><F><L><L><N><L><A><I><S><D><F><L><V><G><A><F><C><I><P><L><Y><V><P><Y><V><L><T><G><R><W><T><F><G><R><G><L><C><K><L><W><L><V><V><D><Y><L><L><C><T><S><S><A><F><N><I><V><L><I><S><Y><D><R><F><L><S><V><T><R><A><V><S><Y><R><A><Q><Q><G><D><T><R><R><A><V><R><K><M><L><L><V><W><V><L><A><F><L><L><Y><G><P><A><I><L><S><W><E><Y><L><S><G><G><S><S><I><P><E><G><H><C><Y><A><E><F><F><Y><N><W><Y><F><L><I><T><A><S><T><L><E><F><F><T><P><F><L><S><V><T><F><F><N><L><S><I><Y><L><N><I><Q><R><R><T><R><L><R><L><D><G><A><R><E><A><A><G><P><E><P><P><P><E><A><Q><P><S><P><P><P><P><P><G><C><W><G><C><W><Q><K><G><H><G><E><A><M><P><L><H><R><Y><G><V><G><E><A><A><V><G><A><E><A><G><E><A><T><L><G><G><G><G><G><G><G><S><V><A><S><P><T><S><S><S><G><S><S><S><R><G><T><E><R><P><R><S><L><K><R><G><S><K><P><S><A><S><S><A><S><L><E><K><R><M><K><M><V><S><Q><S><F><T><Q><R><F><R><L><S><R><D><R><K><V><A><K><S><L><A><V><I><V><S><I><F><G><L><C><W><A><P><Y><T><L><L><M><I><I><R><A><A><C><H><G><H><C><V><P><D><Y><W><Y><E><T><S><F><W><L><L><W><A><N><S><A><V><N><P><V><L><Y><P><L><C><H><H><S><F><R><R><A><F><T><K><L><L><C><P><Q><K><L><K><I><Q><P><H><S><S><L><E><H><C><W><K>
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.<BOP>
Q9Y5N1
Q8NGT7
O2A12_HUMAN
Olfactory receptor OR7-10
Homo
<M><E><S><N><Q><T><W><I><T><E><V><I><L><L><G><F><Q><V><D><P><A><L><E><L><F><L><F><G><F><F><L><L><F><Y><S><L><T><L><M><G><N><G><I><I><L><G><L><I><Y><L><D><S><R><L><H><T><P><M><Y><V><F><L><S><H><L><A><I><V><D><M><S><Y><A><S><S><T><V><P><K><M><L><A><N><L><V><M><H><K><K><V><I><S><F><A><P><C><I><L><Q><T><F><L><Y><L><A><F><A><I><T><E><C><L><I><L><V><M><M><C><Y><D><R><Y><V><A><I><C><H><P><L><Q><Y><T><L><I><M><N><W><R><V><C><T><V><L><A><S><T><C><W><I><F><S><F><L><L><A><L><V><H><I><T><L><I><L><R><L><P><F><C><G><P><Q><K><I><N><H><F><F><C><Q><I><M><S><V><F><K><L><A><C><A><D><T><R><L><N><Q><V><V><L><F><A><G><S><A><F><I><L><V><G><P><L><C><L><V><L><V><S><Y><L><H><I><L><V><A><I><L><R><I><Q><S><G><E><G><R><R><K><A><F><S><T><C><S><S><H><L><C><V><V><G><L><F><F><G><S><A><I><V><M><Y><M><A><P><K><S><S><H><S><Q><E><R><R><K><I><L><S><L><F><Y><S><L><F><N><P><I><L><N><P><L><I><Y><S><L><R><N><A><E><V><K><G><A><L><K><R><V><L><W><K><Q><R><S><M>
Odorant receptor.<BOP>
Q8NGT7
Q4ZJI4
SL9B1_HUMAN
Solute carrier family 9, subfamily B member 1
Homo
<M><H><T><T><E><S><K><N><E><H><L><E><D><E><N><F><Q><T><S><T><T><P><Q><S><L><I><D><P><N><N><T><A><Q><E><E><T><K><T><V><L><S><D><T><E><E><I><K><P><Q><T><K><K><E><T><Y><I><S><C><P><L><R><G><V><L><N><V><I><I><T><N><G><V><I><L><F><V><I><W><C><M><T><W><S><I><L><G><S><E><A><L><P><G><G><N><L><F><G><L><F><I><I><F><Y><S><A><I><I><G><G><K><I><L><Q><L><I><R><I><P><L><V><P><P><L><P><P><L><L><G><M><L><L><A><G><F><T><I><R><N><V><P><F><I><N><E><H><V><H><V><P><N><T><W><S><S><I><L><R><S><I><A><L><T><I><I><L><I><R><A><G><L><G><L><D><P><Q><A><L><R><H><L><K><V><V><C><F><R><L><A><V><G><P><C><L><M><E><A><S><A><A><A><V><F><S><H><F><I><M><K><F><P><W><Q><W><A><F><L><L><G><F><V><L><G><A><V><S><P><A><V><V><V><P><Y><M><M><V><L><Q><E><N><G><Y><G><V><E><E><G><I><P><T><L><L><M><A><A><S><S><M><D><D><I><L><A><I><T><G><F><N><T><C><L><S><I><V><F><S><S><G><G><I><L><N><N><A><I><A><S><I><R><N><V><C><I><S><L><L><A><G><I><V><L><G><F><F><V><R><Y><F><P><S><E><D><Q><K><K><L><T><L><K><R><G><F><L><V><L><T><M><C><V><S><A><V><L><G><S><Q><R><I><G><L><H><G><S><G><G><L><C><T><L><V><L><S><F><I><A><G><T><K><W><S><Q><E><K><M><K><V><Q><K><I><I><T><T><V><W><D><I><F><Q><P><L><L><F><G><L><V><G><A><E><V><S><V><S><S><L><E><S><N><I><V><G><I><S><V><A><T><L><S><L><A><L><C><V><R><I><L><T><T><Y><L><L><M><C><F><A><G><F><S><F><K><E><K><I><F><I><A><L><A><W><M><P><K><A><T><V><Q><A><V><L><G><P><L><A><L><E><T><A><R><V><S><A><P><H><L><E><P><Y><A><K><D><V><M><T><V><A><F><L><A><I><L><I><T><A><P><N><G><A><L><L><M><G><I><L><G><P><K><M><L><T><R><H><Y><D><P><S><K><I><K><L><Q><L><S><T><L><E><H><H>
Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility.<BOP>
Q4ZJI4
Q8NGC9
O11H4_HUMAN
Olfactory receptor OR14-36
Homo
<M><S><F><F><F><V><D><L><R><P><M><N><R><S><A><T><H><I><V><T><E><F><I><L><L><G><F><P><G><C><W><K><I><Q><I><F><L><F><S><L><F><L><V><I><Y><V><L><T><L><L><G><N><G><A><I><I><Y><A><V><R><C><N><P><L><L><H><T><P><M><Y><F><L><L><G><N><F><A><F><L><E><I><W><Y><V><S><S><T><I><P><N><M><L><V><N><I><L><S><K><T><K><A><I><S><F><S><G><C><F><L><Q><F><Y><F><F><F><S><L><G><T><T><E><C><L><F><L><A><V><M><A><Y><D><R><Y><L><A><I><C><H><P><L><Q><Y><P><A><I><M><T><V><R><F><C><G><K><L><V><S><F><C><W><L><I><G><F><L><G><Y><P><I><P><I><F><Y><I><S><Q><L><P><F><C><G><P><N><I><I><D><H><F><L><C><D><M><D><P><L><M><A><L><S><C><A><P><A><P><I><T><E><C><I><F><Y><T><Q><S><S><L><V><L><F><F><T><S><M><Y><I><L><R><S><Y><I><L><L><L><T><A><V><F><Q><V><P><S><A><A><G><R><R><K><A><F><S><T><C><G><S><H><L><V><V><V><S><L><F><Y><G><T><V><M><V><M><Y><V><S><P><T><Y><G><I><P><T><L><L><Q><K><I><L><T><L><V><Y><S><V><T><T><P><L><F><N><P><L><I><Y><T><L><R><N><K><D><M><K><L><A><L><R><N><V><L><F><G><M><R><I><R><Q><N><S>
Odorant receptor.<BOP>
Q8NGC9
Q9BZG2
PPAT_HUMAN
Acid phosphatase 4
Homo
<M><A><G><L><G><F><W><G><H><P><A><G><P><L><L><L><L><L><L><L><V><L><P><P><R><A><L><P><E><G><P><L><V><F><V><A><L><V><F><R><H><G><D><R><A><P><L><A><S><Y><P><M><D><P><H><K><E><V><A><S><T><L><W><P><R><G><L><G><Q><L><T><T><E><G><V><R><Q><Q><L><E><L><G><R><F><L><R><S><R><Y><E><A><F><L><S><P><E><Y><R><R><E><E><V><Y><I><R><S><T><D><F><D><R><T><L><E><S><A><Q><A><N><L><A><G><L><F><P><E><A><A><P><G><S><P><E><A><R><W><R><P><I><P><V><H><T><V><P><V><A><E><D><K><L><L><R><F><P><M><R><S><C><P><R><Y><H><E><L><L><R><E><A><T><E><A><A><E><Y><Q><E><A><L><E><G><W><T><G><F><L><S><R><L><E><N><F><T><G><L><S><L><V><G><E><P><L><R><R><A><W><K><V><L><D><T><L><M><C><Q><Q><A><H><G><L><P><L><P><A><W><A><S><P><D><V><L><R><T><L><A><Q><I><S><A><L><D><I><G><A><H><V><G><P><P><R><A><A><E><K><A><Q><L><T><G><G><I><L><L><N><A><I><L><A><N><F><S><R><V><Q><R><L><G><L><P><L><K><M><V><M><Y><S><A><H><D><S><T><L><L><A><L><Q><G><A><L><G><L><Y><D><G><H><T><P><P><Y><A><A><C><L><G><F><E><F><R><K><H><L><G><N><P><A><K><D><G><G><N><V><T><V><S><L><F><Y><R><N><D><S><A><H><L><P><L><P><L><S><L><P><G><C><P><A><P><C><P><L><G><R><F><Y><Q><L><T><A><P><A><R><P><P><A><H><G><V><S><C><H><G><P><Y><E><A><A><I><P><P><A><P><V><V><P><L><L><A><G><A><V><A><V><L><V><A><L><S><L><G><L><G><L><L><A><W><R><P><G><C><L><R><A><L><G><G><P><V>
May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage . May play a role in odontogenesis .<BOP>
Q9BZG2
Q8N6G5
CGAT2_HUMAN
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2
Homo
<M><P><R><R><G><L><I><L><H><T><R><T><H><W><L><L><L><G><L><A><L><L><C><S><L><V><L><F><M><Y><L><L><E><C><A><P><Q><T><D><G><N><A><S><L><P><G><V><V><G><E><N><Y><G><K><E><Y><Y><Q><A><L><L><Q><E><Q><E><E><H><Y><Q><T><R><A><T><S><L><K><R><Q><I><A><Q><L><K><Q><E><L><Q><E><M><S><E><K><M><R><S><L><Q><E><R><R><N><V><G><A><N><G><I><G><Y><Q><S><N><K><E><Q><A><P><S><D><L><L><E><F><L><H><S><Q><I><D><K><A><E><V><S><I><G><A><K><L><P><S><E><Y><G><V><I><P><F><E><S><F><T><L><M><K><V><F><Q><L><E><M><G><L><T><R><H><P><E><E><K><P><V><R><K><D><K><R><D><E><L><V><E><V><I><E><A><G><L><E><V><I><N><N><P><D><E><D><D><E><Q><E><D><E><E><G><P><L><G><E><K><L><I><F><N><E><N><D><F><V><E><G><Y><Y><R><T><E><R><D><K><G><T><Q><Y><E><L><F><F><K><K><A><D><L><T><E><Y><R><H><V><T><L><F><R><P><F><G><P><L><M><K><V><K><S><E><M><I><D><I><T><R><S><I><I><N><I><I><V><P><L><A><E><R><T><E><A><F><V><Q><F><M><Q><N><F><R><D><V><C><I><H><Q><D><K><K><I><H><L><T><V><V><Y><F><G><K><E><G><L><S><K><V><K><S><I><L><E><S><V><T><S><E><S><N><F><H><N><Y><T><L><V><S><L><N><E><E><F><N><R><G><R><G><L><N><V><G><A><R><A><W><D><K><G><E><V><L><M><F><F><C><D><V><D><I><Y><F><S><A><E><F><L><N><S><C><R><L><N><A><E><P><G><K><K><V><F><Y><P><V><V><F><S><L><Y><N><P><A><I><V><Y><A><N><Q><E><V><P><P><P><V><E><Q><Q><L><V><H><K><K><D><S><G><F><W><R><D><F><G><F><G><M><T><C><Q><Y><R><S><D><F><L><T><I><G><G><F><D><M><E><V><K><G><W><G><G><E><D><V><H><L><Y><R><K><Y><L><H><G><D><L><I><V><I><R><T><P><V><P><G><L><F><H><L><W><H><E><K><R><C><A><D><E><L><T><P><E><Q><Y><R><M><C><I><Q><S><K><A><M><N><E><A><S><H><S><H><L><G><M><L><V><F><R><E><E><I><E><T><H><L><H><K><Q><A><Y><R><T><N><S><E><A><V><G>
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.<BOP>
Q8N6G5
A0A286YF60
SCGR3_HUMAN
Keratin-associated protein 28-3
Homo
<M><G><C><C><G><C><G><S><C><G><G><C><G><G><G><C><G><G><C><G><G><G><C><G><G><G><C><G><G><G><C><G><G><V><C><G><S><C><T><T><C><R><C><Y><R><V><G><C><C><S><S><C><C><P><C><C><R><G><C><C><G><G><C><C><S><T><P><V><I><C><C><C><R><R><T><C><R><S><C><G><C><G><C><R><K><G><C><C><Q><Q><K><C><C><C><Q><K><Q><C><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
A0A286YF60
Q5VZE5
NAA35_HUMAN
Protein MAK10 homolog
Homo
<M><V><M><K><A><S><V><D><D><D><D><S><G><W><E><L><S><M><P><E><K><M><E><K><S><N><T><N><W><V><D><I><T><Q><D><F><E><E><A><C><R><E><L><K><L><G><E><L><L><H><D><K><L><F><G><L><F><E><A><M><S><A><I><E><M><M><D><P><K><M><D><A><G><M><I><G><N><Q><V><N><R><K><V><L><N><F><E><Q><A><I><K><D><G><T><I><K><I><K><D><L><T><L><P><E><L><I><G><I><M><D><T><C><F><C><C><L><I><T><W><L><E><G><H><S><L><A><Q><T><V><F><T><C><L><Y><I><H><N><P><D><F><I><E><D><P><A><M><K><A><F><A><L><G><I><L><K><I><C><D><I><A><R><E><K><V><N><K><A><A><V><F><E><E><E><D><F><Q><S><M><T><Y><G><F><K><M><A><N><S><V><T><D><L><R><V><T><G><M><L><K><D><V><E><D><D><M><Q><R><R><V><K><S><T><R><S><R><Q><G><E><E><R><D><P><E><V><E><L><E><H><Q><Q><C><L><A><V><F><S><R><V><K><F><T><R><V><L><L><T><V><L><I><A><F><T><K><K><E><T><S><A><V><A><E><A><Q><K><L><M><V><Q><A><A><D><L><L><S><A><I><H><N><S><L><H><H><G><I><Q><A><Q><N><D><T><T><K><G><D><H><P><I><M><M><G><F><E><P><L><V><N><Q><R><L><L><P><P><T><F><P><R><Y><A><K><I><I><K><R><E><E><M><V><N><Y><F><A><R><L><I><D><R><I><K><T><V><C><E><V><V><N><L><T><N><L><H><C><I><L><D><F><F><C><E><F><S><E><Q><S><P><C><V><L><S><R><S><L><L><Q><T><T><F><L><V><D><N><K><K><V><F><G><T><H><L><M><Q><D><M><V><K><D><A><L><R><S><F><V><S><P><P><V><L><S><P><K><C><Y><L><Y><N><N><H><Q><A><K><D><C><I><D><S><F><V><T><H><C><V><R><P><F><C><S><L><I><Q><I><H><G><H><N><R><A><R><Q><R><D><K><L><G><H><I><L><E><E><F><A><T><L><Q><D><E><A><E><K><V><D><A><A><L><H><T><M><L><L><K><Q><E><P><Q><R><Q><H><L><A><C><L><G><T><W><V><L><Y><H><N><L><R><I><M><I><Q><Y><L><L><S><G><F><E><L><E><L><Y><S><M><H><E><Y><Y><Y><I><Y><W><Y><L><S><E><F><L><Y><A><W><L><M><S><T><L><S><R><A><D><G><S><Q><M><A><E><E><R><I><M><E><E><Q><Q><K><G><R><S><S><K><K><T><K><K><K><K><K><V><R><P><L><S><R><E><I><T><M><S><Q><A><Y><Q><N><M><C><A><G><M><F><K><T><M><V><A><F><D><M><D><G><K><V><R><K><P><K><F><E><L><D><S><E><Q><V><R><Y><E><H><R><F><A><P><F><N><S><V><M><T><P><P><P><V><H><Y><L><Q><F><K><E><M><S><D><L><N><K><Y><S><P><P><P><Q><S><P><E><L><Y><V><A><A><S><K><H><F><Q><Q><A><K><M><I><L><E><N><I><P><N><P><D><H><E><V><N><R><I><L><K><V><A><K><P><N><F><V><V><M><K><L><L><A><G><G><H><K><K><E><S><K><V><P><P><E><F><D><F><S><A><H><K><Y><F><P><V><V><K><L><V>
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.<BOP>
Q5VZE5
Q9P2M1
LR2BP_HUMAN
Megalin-binding protein
Homo
<M><K><L><T><S><E><K><L><P><K><N><P><F><Y><A><S><V><S><Q><Y><A><A><K><N><Q><K><F><F><Q><W><K><K><E><K><T><D><Y><T><H><A><N><L><V><D><K><A><L><Q><L><L><K><E><R><I><L><K><G><D><T><L><A><Y><F><L><R><G><Q><L><Y><F><E><E><G><W><Y><E><E><A><L><E><Q><F><E><E><I><K><E><K><D><H><Q><A><T><Y><Q><L><G><V><M><Y><Y><D><G><L><G><T><T><L><D><A><E><K><G><V><D><Y><M><K><K><I><L><D><S><P><C><P><K><A><R><H><L><K><F><A><A><A><Y><N><L><G><R><A><Y><Y><E><G><K><G><V><K><R><S><N><E><E><A><E><R><L><W><L><I><A><A><D><N><G><N><P><K><A><S><V><K><A><Q><S><M><L><G><L><Y><Y><S><T><K><E><P><K><E><L><E><K><A><F><Y><W><H><S><E><A><C><G><N><G><N><L><E><S><Q><G><A><L><G><L><M><Y><L><Y><G><Q><G><I><R><Q><D><T><E><A><A><L><Q><C><L><R><E><A><A><E><R><G><N><V><Y><A><Q><G><N><L><V><E><Y><Y><Y><K><M><K><F><F><T><K><C><V><A><F><S><K><R><I><A><D><Y><D><E><V><H><D><I><P><M><I><A><Q><V><T><D><C><L><P><E><F><I><G><R><G><M><A><M><A><S><F><Y><H><A><R><C><L><Q><L><G><L><G><I><T><R><D><E><T><T><A><K><H><Y><Y><S><K><A><C><R><L><N><P><A><L><A><D><E><L><H><S><L><L><I><R><Q><R><I>
May act as an adapter that regulates LRP2 function.<BOP>
Q9P2M1
P31270
HXA11_HUMAN
Homeobox protein Hox-1I
Homo
<M><D><F><D><E><R><G><P><C><S><S><N><M><Y><L><P><S><C><T><Y><Y><V><S><G><P><D><F><S><S><L><P><S><F><L><P><Q><T><P><S><S><R><P><M><T><Y><S><Y><S><S><N><L><P><Q><V><Q><P><V><R><E><V><T><F><R><E><Y><A><I><E><P><A><T><K><W><H><P><R><G><N><L><A><H><C><Y><S><A><E><E><L><V><H><R><D><C><L><Q><A><P><S><A><A><G><V><P><G><D><V><L><A><K><S><S><A><N><V><Y><H><H><P><T><P><A><V><S><S><N><F><Y><S><T><V><G><R><N><G><V><L><P><Q><A><F><D><Q><F><F><E><T><A><Y><G><T><P><E><N><L><A><S><S><D><Y><P><G><D><K><S><A><E><K><G><P><P><A><A><T><A><T><S><A><A><A><A><A><A><A><T><G><A><P><A><T><S><S><S><D><S><G><G><G><G><G><C><R><E><T><A><A><A><A><E><E><K><E><R><R><R><R><P><E><S><S><S><S><P><E><S><S><S><G><H><T><E><D><K><A><G><G><S><S><G><Q><R><T><R><K><K><R><C><P><Y><T><K><Y><Q><I><R><E><L><E><R><E><F><F><F><S><V><Y><I><N><K><E><K><R><L><Q><L><S><R><M><L><N><L><T><D><R><Q><V><K><I><W><F><Q><N><R><R><M><K><E><K><K><I><N><R><D><R><L><Q><Y><Y><S><A><N><P><L><L>
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP>
P31270
P50452
SPB8_HUMAN
Peptidase inhibitor 8
Homo
<M><D><D><L><C><E><A><N><G><T><F><A><I><S><L><F><K><I><L><G><E><E><D><N><S><R><N><V><F><F><S><P><M><S><I><S><S><A><L><A><M><V><F><M><G><A><K><G><S><T><A><A><Q><M><S><Q><A><L><C><L><Y><K><D><G><D><I><H><R><G><F><Q><S><L><L><S><E><V><N><R><T><G><T><Q><Y><L><L><R><T><A><N><R><L><F><G><E><K><T><C><D><F><L><P><D><F><K><E><Y><C><Q><K><F><Y><Q><A><E><L><E><E><L><S><F><A><E><D><T><E><E><C><R><K><H><I><N><D><W><V><A><E><K><T><E><G><K><I><S><E><V><L><D><A><G><T><V><D><P><L><T><K><L><V><L><V><N><A><I><Y><F><K><G><K><W><N><E><Q><F><D><R><K><Y><T><R><G><M><L><F><K><T><N><E><E><K><K><T><V><Q><M><M><F><K><E><A><K><F><K><M><G><Y><A><D><E><V><H><T><Q><V><L><E><L><P><Y><V><E><E><E><L><S><M><V><I><L><L><P><D><D><N><T><D><L><A><V><V><E><K><A><L><T><Y><E><K><F><K><A><W><T><N><S><E><K><L><T><K><S><K><V><Q><V><F><L><P><R><L><K><L><E><E><S><Y><D><L><E><P><F><L><R><R><L><G><M><I><D><A><F><D><E><A><K><A><D><F><S><G><M><S><T><E><K><N><V><P><L><S><K><V><A><H><K><C><F><V><E><V><N><E><E><G><T><E><A><A><A><A><T><A><V><V><R><N><S><R><C><S><R><M><E><P><R><F><C><A><D><H><P><F><L><F><F><I><R><H><H><K><T><N><C><I><L><F><C><G><R><F><S><S><P>
Has an important role in epithelial desmosome-mediated cell-cell adhesion.<BOP>
P50452
Q8NH10
OR8U1_HUMAN
Olfactory receptor 8U1
Homo
<M><A><H><I><N><C><T><Q><A><T><E><F><I><L><V><G><L><T><D><H><Q><E><L><K><M><P><L><F><V><L><F><L><S><I><Y><L><F><T><V><V><G><N><L><G><L><I><L><L><I><R><A><D><T><S><L><N><T><P><M><Y><F><F><L><S><N><L><A><F><V><D><F><C><Y><S><S><V><I><T><P><K><M><L><G><N><F><L><Y><K><Q><N><V><I><S><F><D><A><C><A><T><Q><L><G><C><F><L><T><F><M><I><S><E><S><L><L><L><A><S><M><A><Y><D><R><Y><V><A><I><C><N><P><L><L><Y><M><V><V><M><T><P><G><I><C><I><Q><L><V><A><V><P><Y><S><Y><S><F><L><M><A><L><F><H><T><I><L><T><F><R><L><S><Y><C><H><S><N><I><V><N><H><F><Y><C><D><D><M><P><L><L><R><L><T><C><S><D><T><R><F><K><Q><L><W><I><F><A><C><A><G><I><M><F><I><S><S><L><L><I><V><F><V><S><Y><M><F><I><I><S><A><I><L><R><M><H><S><A><E><G><R><Q><K><A><F><S><T><C><G><S><H><M><L><A><V><T><I><F><Y><G><T><L><I><F><M><Y><L><Q><P><S><S><S><H><A><L><D><T><D><K><M><A><S><V><F><Y><T><V><I><I><P><M><L><N><P><L><I><Y><S><L><Q><N><K><E><V><K><E><A><L><K><K><I><I><I><N><K><N>
Odorant receptor.<BOP>
Q8NH10
Q16322
KCA10_HUMAN
Voltage-gated potassium channel subunit Kv1.8
Homo
<M><D><V><C><G><W><K><E><M><E><V><A><L><V><N><F><D><N><S><D><E><I><Q><E><E><P><G><Y><A><T><D><F><D><S><T><S><P><K><G><R><P><G><G><S><S><F><S><N><G><K><I><L><I><S><E><S><T><N><H><E><T><A><F><S><K><L><P><G><D><Y><A><D><P><P><G><P><E><P><V><V><L><N><E><G><N><Q><R><V><I><I><N><I><A><G><L><R><F><E><T><Q><L><R><T><L><S><Q><F><P><E><T><L><L><G><D><R><E><K><R><M><Q><F><F><D><S><M><R><N><E><Y><F><F><D><R><N><R><P><S><F><D><G><I><L><Y><Y><Y><Q><S><G><G><K><I><R><R><P><A><N><V><P><I><D><I><F><A><D><E><I><S><F><Y><E><L><G><S><E><A><M><D><Q><F><R><E><D><E><G><F><I><K><D><P><E><T><L><L><P><T><N><D><I><H><R><Q><F><W><L><L><F><E><Y><P><E><S><S><S><A><A><R><A><V><A><V><V><S><V><L><V><V><V><I><S><I><T><I><F><C><L><E><T><L><P><E><F><R><E><D><R><E><L><K><V><V><R><D><P><N><L><N><M><S><K><T><V><L><S><Q><T><M><F><T><D><P><F><F><M><V><E><S><T><C><I><V><W><F><T><F><E><L><V><L><R><F><V><V><C><P><S><K><T><D><F><F><R><N><I><M><N><I><I><D><I><I><S><I><I><P><Y><F><A><T><L><I><T><E><L><V><Q><E><T><E><P><S><A><Q><Q><N><M><S><L><A><I><L><R><I><I><R><L><V><R><V><F><R><I><F><K><L><S><R><H><S><K><G><L><Q><I><L><G><Q><T><L><K><A><S><M><R><E><L><G><L><L><I><F><F><L><F><I><G><V><I><L><F><S><S><A><V><Y><F><A><E><V><D><E><P><E><S><H><F><S><S><I><P><D><G><F><W><W><A><V><V><T><M><T><T><V><G><Y><G><D><M><C><P><T><T><P><G><G><K><I><V><G><T><L><C><A><I><A><G><V><L><T><I><A><L><P><V><P><V><I><V><S><N><F><N><Y><F><Y><H><R><E><T><E><N><E><E><K><Q><N><I><P><G><E><I><E><R><I><L><N><S><V><G><S><R><M><G><S><T><D><S><L><N><K><T><N><G><G><C><S><T><E><K><S><R><K>
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.<BOP>
Q16322
Q9H7V2
SYNG1_HUMAN
Transmembrane protein 90B
Homo
<M><D><G><I><I><E><Q><K><S><M><L><V><H><S><K><I><S><D><A><G><K><R><N><G><L><I><N><T><R><N><L><M><A><E><S><R><D><G><L><V><S><V><Y><P><A><P><Q><Y><Q><S><H><R><V><G><A><S><T><V><P><A><S><L><D><S><S><R><S><E><P><M><Q><Q><L><L><D><P><N><T><L><Q><Q><S><V><E><S><R><Y><R><P><N><I><I><L><Y><S><E><G><V><L><R><S><W><G><D><G><V><A><A><D><C><C><E><T><T><F><I><E><D><R><S><P><T><K><D><S><L><E><Y><P><D><G><K><F><I><D><L><S><A><D><D><I><K><I><H><T><L><S><Y><D><V><E><E><E><E><E><F><Q><E><L><E><S><D><Y><S><S><D><T><E><S><E><D><N><F><L><M><M><P><P><R><D><H><L><G><L><S><V><F><S><M><L><C><C><F><W><P><L><G><I><A><A><F><Y><L><S><H><E><T><N><K><A><V><A><K><G><D><L><H><Q><A><S><T><S><S><R><R><A><L><F><L><A><V><L><S><I><T><I><G><T><G><V><Y><V><G><V><A><V><A><L><I><A><Y><L><S><K><N><N><H><L>
May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.<BOP>
Q9H7V2
Q96N21
AP4AT_HUMAN
Tetra-epsin
Homo
<M><A><A><A><P><P><L><R><D><R><L><S><F><L><H><R><L><P><I><L><L><K><G><T><S><D><D><D><V><P><C><P><G><Y><L><F><E><E><I><A><K><I><S><H><E><S><P><G><S><S><Q><C><L><L><E><Y><L><L><S><R><L><H><S><S><S><G><H><G><K><L><K><V><L><K><I><L><L><Y><L><C><S><H><G><S><S><F><F><L><L><I><L><K><R><N><S><A><F><I><Q><E><A><A><A><F><A><G><P><P><D><P><L><H><G><N><S><L><Y><Q><K><V><R><A><A><A><Q><D><L><G><S><T><L><F><S><D><T><V><L><P><L><A><P><S><Q><P><L><G><T><P><P><A><T><G><M><G><S><Q><A><R><P><H><S><T><L><Q><G><F><G><Y><S><K><E><H><G><R><T><A><V><R><H><Q><P><G><Q><A><G><G><G><W><D><E><L><D><S><G><P><S><S><Q><N><S><S><Q><N><S><D><L><S><R><V><S><D><S><G><S><H><S><G><S><D><S><H><S><G><A><S><R><E><P><G><D><L><A><E><R><V><E><V><V><A><L><S><D><C><Q><Q><E><L><S><L><V><R><T><V><T><R><G><P><R><A><F><L><S><R><E><E><A><Q><H><F><I><K><A><C><G><L><L><N><C><E><A><V><L><Q><L><L><T><C><H><L><R><G><T><S><E><C><T><Q><L><R><A><L><C><A><I><A><S><L><G><S><S><D><L><L><P><Q><E><H><I><L><L><R><T><R><P><W><L><Q><E><L><S><M><G><S><P><G><P><V><T><N><K><A><T><K><I><L><R><H><F><E><A><S><C><G><Q><L><S><P><A><R><G><T><S><A><E><P><G><P><T><A><A><L><P><G><P><S><D><L><L><T><D><A><V><P><L><P><G><S><Q><V><F><L><Q><P><L><S><S><T><P><V><S><S><R><S><P><A><P><S><S><G><M><P><S><S><P><V><P><T><P><P><P><D><A><S><P><I><P><A><P><G><D><P><S><E><A><E><A><R><L><A><E><S><R><R><W><R><P><E><R><I><P><G><G><T><D><S><P><K><R><G><P><S><S><C><A><W><S><R><D><S><L><F><A><G><M><E><L><V><A><C><P><R><L><V><G><A><G><A><A><A><G><E><S><C><P><D><A><P><R><A><P><Q><T><S><S><Q><R><T><A><A><K><E><P><P><G><S><E><P><S><A><F><A><F><L><N><A>
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.<BOP>
Q96N21
P57057
G6PT2_HUMAN
Solute carrier family 37 member 1
Homo
<M><A><R><L><P><A><G><I><R><F><I><I><S><F><S><R><D><Q><W><Y><R><A><F><I><F><I><L><T><F><L><L><Y><A><S><F><H><L><S><R><K><P><I><S><I><V><K><G><E><L><H><K><Y><C><T><A><W><D><E><A><D><V><R><F><S><S><Q><N><R><K><S><G><S><A><A><P><H><Q><L><P><D><N><E><T><D><C><G><W><A><P><F><D><K><N><N><Y><Q><Q><L><L><G><A><L><D><Y><S><F><L><C><A><Y><A><V><G><M><Y><L><S><G><I><I><G><E><R><L><P><I><R><Y><Y><L><T><F><G><M><L><A><S><G><A><F><T><A><L><F><G><L><G><Y><F><Y><N><I><H><S><F><G><F><Y><V><V><T><Q><V><I><N><G><L><V><Q><T><T><G><W><P><S><V><V><T><C><L><G><N><W><F><G><K><G><R><R><G><L><I><M><G><V><W><N><S><H><T><S><V><G><N><I><L><G><S><L><I><A><G><Y><W><V><S><T><C><W><G><L><S><F><V><V><P><G><A><I><V><A><A><M><G><I><V><C><F><L><F><L><I><E><H><P><N><D><V><R><C><S><S><T><L><V><T><H><S><K><G><Y><E><N><G><T><N><R><L><R><L><Q><K><Q><I><L><K><S><E><K><N><K><P><L><D><P><E><M><Q><C><L><L><L><S><D><G><K><G><S><I><H><P><N><H><V><V><I><L><P><G><D><G><G><S><G><T><A><A><I><S><F><T><G><A><L><K><I><P><G><V><I><E><F><S><L><C><L><L><F><A><K><L><V><S><Y><T><F><L><F><W><L><P><L><Y><I><T><N><V><D><H><L><D><A><K><K><A><G><E><L><S><T><L><F><D><V><G><G><I><F><G><G><I><L><A><G><V><I><S><D><R><L><E><K><R><A><S><T><C><G><L><M><L><L><L><A><A><P><T><L><Y><I><F><S><T><V><S><K><M><G><L><E><A><T><I><A><M><L><L><L><S><G><A><L><V><S><G><P><Y><T><L><I><T><T><A><V><S><A><D><L><G><T><H><K><S><L><K><G><N><A><H><A><L><S><T><V><T><A><I><I><D><G><T><G><S><V><G><A><A><L><G><P><L><L><A><G><L><L><S><P><S><G><W><S><N><V><F><Y><M><L><M><F><A><D><A><C><A><L><L><F><L><I><R><L><I><H><K><E><L><S><C><P><G><S><A><T><G><D><Q><V><P><F><K><E><Q>
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.<BOP>
P57057
P49902
5NTC_HUMAN
High Km 5'-nucleotidase
Homo
<M><S><T><S><W><S><D><R><L><Q><N><A><A><D><M><P><A><N><M><D><K><H><A><L><K><K><Y><R><R><E><A><Y><H><R><V><F><V><N><R><S><L><A><M><E><K><I><K><C><F><G><F><D><M><D><Y><T><L><A><V><Y><K><S><P><E><Y><E><S><L><G><F><E><L><T><V><E><R><L><V><S><I><G><Y><P><Q><E><L><L><S><F><A><Y><D><S><T><F><P><T><R><G><L><V><F><D><T><L><Y><G><N><L><L><K><V><D><A><Y><G><N><L><L><V><C><A><H><G><F><N><F><I><R><G><P><E><T><R><E><Q><Y><P><N><K><F><I><Q><R><D><D><T><E><R><F><Y><I><L><N><T><L><F><N><L><P><E><T><Y><L><L><A><C><L><V><D><F><F><T><N><C><P><R><Y><T><S><C><E><T><G><F><K><D><G><D><L><F><M><S><Y><R><S><M><F><Q><D><V><R><D><A><V><D><W><V><H><Y><K><G><S><L><K><E><K><T><V><E><N><L><E><K><Y><V><V><K><D><G><K><L><P><L><L><L><S><R><M><K><E><V><G><K><V><F><L><A><T><N><S><D><Y><K><Y><T><D><K><I><M><T><Y><L><F><D><F><P><H><G><P><K><P><G><S><S><H><R><P><W><Q><S><Y><F><D><L><I><L><V><D><A><R><K><P><L><F><F><G><E><G><T><V><L><R><Q><V><D><T><K><T><G><K><L><K><I><G><T><Y><T><G><P><L><Q><H><G><I><V><Y><S><G><G><S><S><D><T><I><C><D><L><L><G><A><K><G><K><D><I><L><Y><I><G><D><H><I><F><G><D><I><L><K><S><K><K><R><Q><G><W><R><T><F><L><V><I><P><E><L><A><Q><E><L><H><V><W><T><D><K><S><S><L><F><E><E><L><Q><S><L><D><I><F><L><A><E><L><Y><K><H><L><D><S><S><S><N><E><R><P><D><I><S><S><I><Q><R><R><I><K><K><V><T><H><D><M><D><M><C><Y><G><M><M><G><S><L><F><R><S><G><S><R><Q><T><L><F><A><S><Q><V><M><R><Y><A><D><L><Y><A><A><S><F><I><N><L><L><Y><Y><P><F><S><Y><L><F><R><A><A><H><V><L><M><P><H><E><S><T><V><E><H><T><H><V><D><I><N><E><M><E><S><P><L><A><T><R><N><R><T><S><V><D><F><K><D><T><D><Y><K><R><H><Q><L><T><R><S><I><S><E><I><K><P><P><N><L><F><P><L><A><P><Q><E><I><T><H><C><H><D><E><D><D><D><E><E><E><E><E><E><E><E>
Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates . In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine . Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP . Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency . Through these activities regulates the purine nucleoside/nucleotide pools within the cell .<BOP>
P49902
O00273
DFFA_HUMAN
Inhibitor of CAD
Homo
<M><E><V><T><G><D><A><G><V><P><E><S><G><E><I><R><T><L><K><P><C><L><L><R><R><N><Y><S><R><E><Q><H><G><V><A><A><S><C><L><E><D><L><R><S><K><A><C><D><I><L><A><I><D><K><S><L><T><P><V><T><L><V><L><A><E><D><G><T><I><V><D><D><D><D><Y><F><L><C><L><P><S><N><T><K><F><V><A><L><A><S><N><E><K><W><A><Y><N><N><S><D><G><G><T><A><W><I><S><Q><E><S><F><D><V><D><E><T><D><S><G><A><G><L><K><W><K><N><V><A><R><Q><L><K><E><D><L><S><S><I><I><L><L><S><E><E><D><L><Q><M><L><V><D><A><P><C><S><D><L><A><Q><E><L><R><Q><S><C><A><T><V><Q><R><L><Q><H><T><L><Q><Q><V><L><D><Q><R><E><E><V><R><Q><S><K><Q><L><L><Q><L><Y><L><Q><A><L><E><K><E><G><S><L><L><S><K><Q><E><E><S><K><A><A><F><G><E><E><V><D><A><V><D><T><G><I><S><R><E><T><S><S><D><V><A><L><A><S><H><I><L><T><A><L><R><E><K><Q><A><P><E><L><S><L><S><S><Q><D><L><E><L><V><T><K><E><D><P><K><A><L><A><V><A><L><N><W><D><I><K><K><T><E><T><V><Q><E><A><C><E><R><E><L><A><L><R><L><Q><Q><T><Q><S><L><H><S><L><R><S><I><S><A><S><K><A><S><P><P><G><D><L><Q><N><P><K><R><A><R><Q><D><P><T>
Inhibitor of the caspase-activated DNase (DFF40).<BOP>
O00273
Q9NYK6
EURL_HUMAN
Protein EURL homolog
Homo
<M><N><E><E><E><Q><F><V><N><I><D><L><N><D><D><N><I><C><S><V><C><K><L><G><T><D><K><E><T><L><S><F><C><H><I><C><F><E><L><N><I><E><G><V><P><K><S><D><L><L><H><T><K><S><L><R><G><H><K><D><C><F><E><K><Y><H><L><I><A><N><Q><G><C><P><R><S><K><L><S><K><S><T><Y><E><E><V><K><T><I><L><S><K><K><I><N><W><I><V><Q><Y><A><Q><N><K><D><L><D><S><D><S><E><C><S><K><N><P><Q><H><H><L><F><N><F><R><H><K><P><E><E><K><L><L><P><Q><F><D><S><Q><V><P><K><Y><S><A><K><W><I><D><G><S><A><G><G><I><S><N><C><T><Q><R><I><L><E><Q><R><E><N><T><D><F><G><L><S><M><L><Q><D><S><G><A><T><L><C><R><N><S><V><L><W><P><H><S><H><N><Q><A><Q><K><K><E><E><T><I><S><S><P><E><A><N><V><Q><T><Q><H><P><H><Y><S><R><E><E><L><N><S><M><T><L><G><E><V><E><Q><L><N><A><K><L><L><Q><Q><I><Q><E><V><F><E><E><L><T><H><Q><V><Q><E><K><D><S><L><A><S><Q><L><H><V><R><H><V><A><I><E><Q><L><L><K><N><C><S><K><L><P><C><L><Q><V><G><R><T><G><M><K><S><H><L><P><I><N><N>
Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.<BOP>
Q9NYK6
Q8NBM8
PCYXL_HUMAN
Prenylcysteine oxidase-like
Homo
<M><A><R><A><A><P><L><L><A><A><L><T><A><L><L><A><A><A><A><A><G><G><D><A><P><P><G><K><I><A><V><V><G><A><G><I><G><G><S><A><V><A><H><F><L><Q><Q><H><F><G><P><R><V><Q><I><D><V><Y><E><K><G><T><V><G><G><R><L><A><T><I><S><V><N><K><Q><H><Y><E><S><G><A><A><S><F><H><S><L><S><L><H><M><Q><D><F><V><K><L><L><G><L><R><H><R><R><E><V><V><G><R><S><A><I><F><G><G><E><H><F><M><L><E><E><T><D><W><Y><L><L><N><L><F><R><L><W><W><H><Y><G><I><S><F><L><R><L><Q><M><W><V><E><E><V><M><E><K><F><M><R><I><Y><K><Y><Q><A><H><G><Y><A><F><S><G><V><E><E><L><L><Y><S><L><G><E><S><T><F><V><N><M><T><Q><H><S><V><A><E><S><L><L><Q><V><G><V><T><Q><R><F><I><D><D><V><V><S><A><V><L><R><A><S><Y><G><Q><S><A><A><M><P><A><F><A><G><A><M><S><L><A><G><A><Q><G><S><L><W><S><V><E><G><G><N><K><L><V><C><S><G><L><L><K><L><T><K><A><N><V><I><H><A><T><V><T><S><V><T><L><H><S><T><E><G><K><A><L><Y><Q><V><A><Y><E><N><E><V><G><N><S><S><D><F><Y><D><I><V><V><I><A><T><P><L><H><L><D><N><S><S><S><N><L><T><F><A><G><F><H><P><P><I><D><D><V><Q><G><S><F><Q><P><T><V><V><S><L><V><H><G><Y><L><N><S><S><Y><F><G><F><P><D><P><K><L><F><P><F><A><N><I><L><T><T><D><F><P><S><F><F><C><T><L><D><N><I><C><P><V><N><I><S><A><S><F><R><R><K><Q><P><Q><E><A><A><V><W><R><V><Q><S><P><K><P><L><F><R><T><Q><L><K><T><L><F><R><S><Y><Y><S><V><Q><T><A><E><W><Q><A><H><P><L><Y><G><S><R><P><T><L><P><R><F><A><L><H><D><Q><L><F><Y><L><N><A><L><E><W><A><A><S><S><V><E><V><M><A><V><A><A><K><N><V><A><L><L><A><Y><N><R><W><Y><Q><D><L><D><K><I><D><Q><K><D><L><M><H><K><V><K><T><E><L>
Probable oxidoreductase.<BOP>
Q8NBM8
Q2T9J0
TYSD1_HUMAN
Peroxisomal leader peptide-processing protease, 45 kDa form
Homo
<M><R><R><Q><W><G><S><A><M><R><A><A><E><Q><A><G><C><M><V><S><A><S><R><A><G><Q><P><E><A><G><P><W><S><C><S><G><V><I><L><S><R><S><P><G><L><V><L><C><H><G><G><I><F><V><P><F><L><R><A><G><S><E><V><L><T><A><A><G><A><V><F><L><P><G><D><S><C><R><D><D><L><R><L><H><V><Q><W><A><P><T><A><A><G><P><G><G><G><A><E><R><G><R><P><G><L><C><T><P><Q><C><A><S><L><E><P><G><P><P><A><P><S><R><G><R><P><L><Q><P><R><L><P><A><E><L><L><L><L><L><S><C><P><A><F><W><A><H><F><A><R><L><F><G><D><E><A><A><E><Q><W><R><F><S><S><A><A><R><D><D><E><V><S><E><D><E><E><A><D><Q><L><R><A><L><G><W><F><A><L><L><G><V><R><L><G><Q><E><E><V><E><E><E><R><G><P><A><M><A><V><S><P><L><G><A><V><P><K><G><A><P><L><L><V><C><G><S><P><F><G><A><F><C><P><D><I><F><L><N><T><L><S><C><G><V><L><S><N><V><A><G><P><L><L><L><T><D><A><R><C><L><P><G><T><E><G><G><G><V><F><T><A><R><P><A><G><A><L><V><A><L><V><V><A><P><L><C><W><K><A><G><E><W><V><G><F><T><L><L><C><A><A><A><P><L><F><R><A><A><R><D><A><L><H><R><L><P><H><S><T><A><A><L><A><A><L><L><P><P><E><V><G><V><P><W><G><L><P><L><R><D><S><G><P><L><W><A><A><A><A><V><L><V><E><C><G><T><V><W><G><S><G><V><A><V><A><P><R><L><V><V><T><C><R><H><V><S><P><R><E><A><A><R><V><L><V><R><S><T><T><P><K><S><V><A><I><W><G><R><V><V><F><A><T><Q><E><T><C><P><Y><D><I><A><V><V><S><L><E><E><D><L><D><D><V><P><I><P><V><P><A><E><H><F><H><E><G><E><A><V><S><V><V><G><F><G><V><F><G><Q><S><C><G><P><S><V><T><S><G><I><L><S><A><V><V><Q><V><N><G><T><P><V><M><L><Q><T><T><C><A><V><H><S><G><S><S><G><G><P><L><F><S><N><H><S><G><N><L><L><G><I><I><T><S><N><T><R><D><N><N><T><G><A><T><Y><P><H><L><N><F><S><I><P><I><T><V><L><Q><P><A><L><Q><Q><Y><S><Q><T><Q><D><L><G><G><L><R><E><L><D><R><A><A><E><P><V><R><V><V><W><R><L><Q><R><P><L><A><E><A><P><R><S><K><L>
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.<BOP>
Q2T9J0
Q00887
PSG9_HUMAN
Pregnancy-specific glycoprotein 7
Homo
<M><G><P><L><P><A><P><S><C><T><Q><R><I><T><W><K><G><L><L><L><T><A><S><L><L><N><F><W><N><P><P><T><T><A><E><V><T><I><E><A><Q><P><P><K><V><S><E><G><K><D><V><L><L><L><V><H><N><L><P><Q><N><L><P><G><Y><F><W><Y><K><G><E><M><T><D><L><Y><H><Y><I><I><S><Y><I><V><D><G><K><I><I><I><Y><G><P><A><Y><S><G><R><E><T><V><Y><S><N><A><S><L><L><I><Q><N><V><T><R><K><D><A><G><T><Y><T><L><H><I><I><K><R><G><D><E><T><R><E><E><I><R><H><F><T><F><T><L><Y><L><E><T><P><K><P><Y><I><S><S><S><N><L><N><P><R><E><A><M><E><A><V><R><L><I><C><D><P><E><T><L><D><A><S><Y><L><W><W><M><N><G><Q><S><L><P><V><T><H><R><L><Q><L><S><K><T><N><R><T><L><Y><L><F><G><V><T><K><Y><I><A><G><P><Y><E><C><E><I><R><N><P><V><S><A><S><R><S><D><P><V><T><L><N><L><L><P><K><L><P><I><P><Y><I><T><I><N><N><L><N><P><R><E><N><K><D><V><L><A><F><T><C><E><P><K><S><E><N><Y><T><Y><I><W><W><L><N><G><Q><S><L><P><V><S><P><G><V><K><R><P><I><E><N><R><I><L><I><L><P><S><V><T><R><N><E><T><G><P><Y><Q><C><E><I><R><D><R><Y><G><G><L><R><S><N><P><V><I><L><N><V><L><Y><G><P><D><L><P><R><I><Y><P><S><F><T><Y><Y><R><S><G><E><N><L><D><L><S><C><F><T><E><S><N><P><P><A><E><Y><F><W><T><I><N><G><K><F><Q><Q><S><G><Q><K><L><F><I><P><Q><I><T><R><N><H><S><G><L><Y><A><C><S><V><H><N><S><A><T><G><K><E><I><S><K><S><M><T><V><K><V><S><G><P><C><H><G><D><L><T><E><S><Q><S>
Binds to the small latent transforming growth factor-beta complex, consisting of the N-terminal TGFB1 latency-associated peptide (LAP) and the mature form of TGFB1, thereby leading to the activation of TGFB1 . The activation of TGFB1 leads to stimulation of naive CD4(+) T-cells to increase FoxP3 expression and to an increase in the number of FoxP3(+) regulatory T-cells . Induces the differentiation of a suppressive CD4(+)LAP(+)FoxP3(-) T-cell subset . Induces the secretion of TGFB1 in macrophages, but not in activated CD4(+) T-cells . May reduce the expression of several pro-inflammatory cytokines and chemokines by CD4(+) T-cells, including IL2 and IL6 .<BOP>
Q00887
Q15327
ANKR1_HUMAN
Cytokine-inducible nuclear protein
Homo
<M><M><V><L><K><V><E><E><L><V><T><G><K><K><N><G><N><G><E><A><G><E><F><L><P><E><D><F><R><D><G><E><Y><E><A><A><V><T><L><E><K><Q><E><D><L><K><T><L><L><A><H><P><V><T><L><G><E><Q><Q><W><K><S><E><K><Q><R><E><A><E><L><K><K><K><K><L><E><Q><R><S><K><L><E><N><L><E><D><L><E><I><I><I><Q><L><K><K><R><K><K><Y><R><K><T><K><V><P><V><V><K><E><P><E><P><E><I><I><T><E><P><V><D><V><P><T><F><L><K><A><A><L><E><N><K><L><P><V><V><E><K><F><L><S><D><K><N><N><P><D><V><C><D><E><Y><K><R><T><A><L><H><R><A><C><L><E><G><H><L><A><I><V><E><K><L><M><E><A><G><A><Q><I><E><F><R><D><M><L><E><S><T><A><I><H><W><A><S><R><G><G><N><L><D><V><L><K><L><L><L><N><K><G><A><K><I><S><A><R><D><K><L><L><S><T><A><L><H><V><A><V><R><T><G><H><Y><E><C><A><E><H><L><I><A><C><E><A><D><L><N><A><K><D><R><E><G><D><T><P><L><H><D><A><V><R><L><N><R><Y><K><M><I><R><L><L><I><M><Y><G><A><D><L><N><I><K><N><C><A><G><K><T><P><M><D><L><V><L><H><W><Q><N><G><T><K><A><I><F><D><S><L><R><E><N><S><Y><K><T><S><R><I><A><T><F>
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.<BOP>
Q15327
Q8N690
DB119_HUMAN
ESC42-RELA
Homo
<M><K><L><L><Y><L><F><L><A><I><L><L><A><I><E><E><P><V><I><S><G><K><R><H><I><L><R><C><M><G><N><S><G><I><C><R><A><S><C><K><K><N><E><Q><P><Y><L><Y><C><R><N><C><Q><S><C><C><L><Q><S><Y><M><R><I><S><I><S><G><K><E><E><N><T><D><W><S><Y><E><K><Q><W><P><R><L><P>
Has antibacterial activity.<BOP>
Q8N690
Q9BRV8
SIKE1_HUMAN
Suppressor of IKK-epsilon
Homo
<M><S><C><T><I><E><K><I><L><T><D><A><K><T><L><L><E><R><L><R><E><H><D><A><A><A><E><S><L><V><D><Q><S><A><A><L><H><R><R><V><A><A><M><R><E><A><G><T><A><L><P><D><Q><Y><Q><E><D><A><S><D><M><K><D><M><S><K><Y><K><P><H><I><L><L><S><Q><E><N><T><Q><I><R><D><L><Q><Q><E><N><R><E><L><W><I><S><L><E><E><H><Q><D><A><L><E><L><I><M><S><K><Y><R><K><Q><M><L><Q><L><M><V><A><K><K><A><V><D><A><E><P><V><L><K><A><H><Q><S><H><S><A><E><I><E><S><Q><I><D><R><I><C><E><M><G><E><V><M><R><K><A><V><Q><V><D><D><D><Q><F><C><K><I><Q><E><K><L><A><Q><L><E><L><E><N><K><E><L><R><E><L><L><S><I><S><S><E><S><L><Q><A><R><K><E><N><S><M><D><T><A><S><Q><A><I><K>
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.<BOP>
Q9BRV8
Q9NY12
GAR1_HUMAN
snoRNP protein GAR1
Homo
<M><S><F><R><G><G><G><R><G><G><F><N><R><G><G><G><G><G><G><F><N><R><G><G><S><S><N><H><F><R><G><G><G><G><G><G><G><G><G><N><F><R><G><G><G><R><G><G><F><G><R><G><G><G><R><G><G><F><N><K><G><Q><D><Q><G><P><P><E><R><V><V><L><L><G><E><F><L><H><P><C><E><D><D><I><V><C><K><C><T><T><D><E><N><K><V><P><Y><F><N><A><P><V><Y><L><E><N><K><E><Q><I><G><K><V><D><E><I><F><G><Q><L><R><D><F><Y><F><S><V><K><L><S><E><N><M><K><A><S><S><F><K><K><L><Q><K><F><Y><I><D><P><Y><K><L><L><P><L><Q><R><F><L><P><R><P><P><G><E><K><G><P><P><R><G><G><G><R><G><G><R><G><G><G><R><G><G><G><G><R><G><G><G><R><G><G><G><F><R><G><G><R><G><G><G><G><G><G><F><R><G><G><R><G><G><G><F><R><G><R><G><H>
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.<BOP>
Q9NY12
Q8IXI1
MIRO2_HUMAN
Ras homolog gene family member T2
Homo
<M><R><R><D><V><R><I><L><L><L><G><E><A><Q><V><G><K><T><S><L><I><L><S><L><V><G><E><E><F><P><E><E><V><P><P><R><A><E><E><I><T><I><P><A><D><V><T><P><E><K><V><P><T><H><I><V><D><Y><S><E><A><E><Q><T><D><E><E><L><R><E><E><I><H><K><A><N><V><V><C><V><V><Y><D><V><S><E><E><A><T><I><E><K><I><R><T><K><W><I><P><L><V><N><G><G><T><T><Q><G><P><R><V><P><I><I><L><V><G><N><K><S><D><L><R><S><G><S><S><M><E><A><V><L><P><I><M><S><Q><F><P><E><I><E><T><C><V><E><C><S><A><K><N><L><R><N><I><S><E><L><F><Y><Y><A><Q><K><A><V><L><H><P><T><A><P><L><Y><D><P><E><A><K><Q><L><R><P><A><C><A><Q><A><L><T><R><I><F><R><L><S><D><Q><D><L><D><Q><A><L><S><D><E><E><L><N><A><F><Q><K><S><C><F><G><H><P><L><A><P><Q><A><L><E><D><V><K><T><V><V><C><R><N><V><A><G><G><V><R><E><D><R><L><T><L><D><G><F><L><F><L><N><T><L><F><I><Q><R><G><R><H><E><T><T><W><T><I><L><R><R><F><G><Y><S><D><A><L><E><L><T><A><D><Y><L><S><P><L><I><H><V><P><P><G><C><S><T><E><L><N><H><L><G><Y><Q><F><V><Q><R><V><F><E><K><H><D><Q><D><R><D><G><A><L><S><P><V><E><L><Q><S><L><F><S><V><F><P><A><A><P><W><G><P><E><L><P><R><T><V><R><T><E><A><G><R><L><P><L><H><G><Y><L><C><Q><W><T><L><V><T><Y><L><D><V><R><S><C><L><G><H><L><G><Y><L><G><Y><P><T><L><C><E><Q><D><Q><A><H><A><I><T><V><T><R><E><K><R><L><D><Q><E><K><G><Q><T><Q><R><S><V><L><L><C><K><V><V><G><A><R><G><V><G><K><S><A><F><L><Q><A><F><L><G><R><G><L><G><H><Q><D><T><R><E><Q><P><P><G><Y><A><I><D><T><V><Q><V><N><G><Q><E><K><Y><L><I><L><C><E><V><G><T><D><G><L><L><A><T><S><L><D><A><T><C><D><V><A><C><L><M><F><D><G><S><D><P><K><S><F><A><H><C><A><S><V><Y><K><H><H><Y><M><D><G><Q><T><P><C><L><F><V><S><S><K><A><D><L><P><E><G><V><A><V><S><G><P><S><P><A><E><F><C><R><K><H><R><L><P><A><P><V><P><F><S><C><A><G><P><A><E><P><S><T><T><I><F><T><Q><L><A><T><M><A><A><F><P><H><L><V><H><A><E><L><H><P><S><S><F><W><L><R><G><L><L><G><V><V><G><A><A><V><A><A><V><L><S><F><S><L><Y><R><V><L><V><K><S><Q>
Mitochondrial GTPase involved in mitochondrial trafficking . Probably involved in control of anterograde transport of mitochondria and their subcellular distribution .<BOP>
Q8IXI1
A0A0A0MS15
HV349_HUMAN
Immunoglobulin heavy variable 3-49
Homo
<M><E><F><G><L><S><W><V><F><L><V><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><R><S><L><R><L><S><C><T><A><S><G><F><T><F><G><D><Y><A><M><S><W><V><R><Q><A><P><G><K><G><L><E><W><V><G><F><I><R><S><K><A><Y><G><G><T><T><E><Y><A><A><S><V><K><G><R><F><T><I><S><R><D><D><S><K><S><I><A><Y><L><Q><M><N><S><L><K><T><E><D><T><A><V><Y><Y><C><T><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0A0MS15
O95848
NUD14_HUMAN
Nucleoside diphosphate-linked moiety X motif 14
Homo
<M><E><R><I><E><G><A><S><V><G><R><C><A><A><S><P><Y><L><R><P><L><T><L><H><Y><R><Q><N><G><A><Q><K><S><W><D><F><M><K><T><H><D><S><V><T><V><L><L><F><N><S><S><R><R><S><L><V><L><V><K><Q><F><R><P><A><V><Y><A><G><E><V><E><R><R><F><P><G><S><L><A><A><V><D><Q><D><G><P><R><E><L><Q><P><A><L><P><G><S><A><G><V><T><V><E><L><C><A><G><L><V><D><Q><P><G><L><S><L><E><E><V><A><C><K><E><A><W><E><E><C><G><Y><H><L><A><P><S><D><L><R><R><V><A><T><Y><W><S><G><V><G><L><T><G><S><R><Q><T><M><F><Y><T><E><V><T><D><A><Q><R><S><G><P><G><G><G><L><V><E><E><G><E><L><I><E><V><V><H><L><P><L><E><G><A><Q><A><F><A><D><D><P><D><I><P><K><T><L><G><V><I><F><G><V><S><W><F><L><S><Q><V><A><P><N><L><D><L><Q>
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.<BOP>
O95848
Q9UMS0
NFU1_HUMAN
HIRA-interacting protein 5
Homo
<M><A><A><T><A><R><R><G><W><G><A><A><A><V><A><A><G><L><R><R><R><F><C><H><M><L><K><N><P><Y><T><I><K><K><Q><P><L><H><Q><F><V><Q><R><P><L><F><P><L><P><A><A><F><Y><H><P><V><R><Y><M><F><I><Q><T><Q><D><T><P><N><P><N><S><L><K><F><I><P><G><K><P><V><L><E><T><R><T><M><D><F><P><T><P><A><A><A><F><R><S><P><L><A><R><Q><L><F><R><I><E><G><V><K><S><V><F><F><G><P><D><F><I><T><V><T><K><E><N><E><E><L><D><W><N><L><L><K><P><D><I><Y><A><T><I><M><D><F><F><A><S><G><L><P><L><V><T><E><E><T><P><S><G><E><A><G><S><E><E><D><D><E><V><V><A><M><I><K><E><L><L><D><T><R><I><R><P><T><V><Q><E><D><G><G><D><V><I><Y><K><G><F><E><D><G><I><V><Q><L><K><L><Q><G><S><C><T><S><C><P><S><S><I><I><T><L><K><N><G><I><Q><N><M><L><Q><F><Y><I><P><E><V><E><G><V><E><Q><V><M><D><D><E><S><D><E><K><E><A><N><S><P>
Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins.<BOP>
Q9UMS0
Q8NGJ1
OR4D6_HUMAN
Olfactory receptor OR11-250
Homo
<M><D><Q><I><N><H><T><N><V><K><E><F><F><F><L><E><L><T><R><S><R><E><L><E><F><F><L><F><V><V><F><F><A><V><Y><V><A><T><V><L><G><N><A><L><I><V><V><T><I><T><C><E><S><R><L><H><T><P><M><Y><F><L><L><R><N><K><S><V><L><D><I><V><F><S><S><I><T><V><P><K><F><L><V><D><L><L><S><D><R><K><T><I><S><Y><N><D><C><M><A><Q><I><F><F><F><H><F><A><G><G><A><D><I><F><F><L><S><V><M><A><Y><D><R><Y><L><A><I><A><K><P><L><H><Y><V><T><M><M><R><K><E><V><W><V><A><L><V><V><A><S><W><V><S><G><G><L><H><S><I><I><Q><V><I><L><M><L><P><F><P><F><C><G><P><N><T><L><D><A><F><Y><C><Y><V><L><Q><V><V><K><L><A><C><T><D><T><F><A><L><E><L><F><M><I><S><N><N><G><L><V><T><L><L><W><F><L><L><L><L><G><S><Y><T><V><I><L><V><M><L><R><S><H><S><G><E><G><R><N><K><A><L><S><T><C><T><S><H><M><L><V><V><T><L><H><F><V><P><C><V><Y><I><Y><C><R><P><F><M><T><L><P><M><D><T><T><I><S><I><N><N><T><V><I><T><P><M><L><N><P><I><I><Y><S><L><R><N><Q><E><M><K><S><A><M><Q><R><L><Q><R><R><L><G><P><S><E><S><R><K><W><G>
Odorant receptor.<BOP>
Q8NGJ1
Q14106
TOB2_HUMAN
Transducer of erbB-2 2
Homo
<M><Q><L><E><I><K><V><A><L><N><F><I><I><S><Y><L><Y><N><K><L><P><R><R><R><A><D><L><F><G><E><E><L><E><R><L><L><K><K><K><Y><E><G><H><W><Y><P><E><K><P><L><K><G><S><G><F><R><C><V><H><I><G><E><M><V><D><P><V><V><E><L><A><A><K><R><S><G><L><A><V><E><D><V><R><A><N><V><P><E><E><L><S><V><W><I><D><P><F><E><V><S><Y><Q><I><G><E><K><G><A><V><K><V><L><Y><L><D><D><S><E><G><C><G><A><P><E><L><D><K><E><I><K><S><S><F><N><P><D><A><Q><V><F><V><P><I><G><S><Q><D><S><S><L><S><N><S><P><S><P><S><F><G><Q><S><P><S><P><T><F><I><P><R><S><A><Q><P><I><T><F><T><T><A><S><F><A><A><T><K><F><G><S><T><K><M><K><K><G><G><G><A><A><S><G><G><G><V><A><S><S><G><A><G><G><Q><Q><P><P><Q><Q><P><R><M><A><R><S><P><T><N><S><L><L><K><H><K><S><L><S><L><S><M><H><S><L><N><F><I><T><A><N><P><A><P><Q><S><Q><L><S><P><N><A><K><E><F><V><Y><N><G><G><G><S><P><S><L><F><F><D><A><A><D><G><Q><G><S><G><T><P><G><P><F><G><G><S><G><A><G><T><C><N><S><S><S><F><D><M><A><Q><V><F><G><G><G><A><N><S><L><F><L><E><K><T><P><F><V><E><G><L><S><Y><N><L><N><T><M><Q><Y><P><S><Q><Q><F><Q><P><V><V><L><A><N>
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.<BOP>
Q14106
Q4G176
ACSF3_HUMAN
Acyl-CoA synthetase family member 3
Homo
<M><L><P><H><V><V><L><T><F><R><R><L><G><C><A><L><A><S><C><R><L><A><P><A><R><H><R><G><S><G><L><L><H><T><A><P><V><A><R><S><D><R><S><A><P><V><F><T><R><A><L><A><F><G><D><R><I><A><L><V><D><Q><H><G><R><H><T><Y><R><E><L><Y><S><R><S><L><R><L><S><Q><E><I><C><R><L><C><G><C><V><G><G><D><L><R><E><E><R><V><S><F><L><C><A><N><D><A><S><Y><V><V><A><Q><W><A><S><W><M><S><G><G><V><A><V><P><L><Y><R><K><H><P><A><A><Q><L><E><Y><V><I><C><D><S><Q><S><S><V><V><L><A><S><Q><E><Y><L><E><L><L><S><P><V><V><R><K><L><G><V><P><L><L><P><L><T><P><A><I><Y><T><G><A><V><E><E><P><A><E><V><P><V><P><E><Q><G><W><R><N><K><G><A><M><I><I><Y><T><S><G><T><T><G><R><P><K><G><V><L><S><T><H><Q><N><I><R><A><V><V><T><G><L><V><H><K><W><A><W><T><K><D><D><V><I><L><H><V><L><P><L><H><H><V><H><G><V><V><N><A><L><L><C><P><L><W><V><G><A><T><C><V><M><M><P><E><F><S><P><Q><Q><V><W><E><K><F><L><S><S><E><T><P><R><I><N><V><F><M><A><V><P><T><I><Y><T><K><L><M><E><Y><Y><D><R><H><F><T><Q><P><H><A><Q><D><F><L><R><A><V><C><E><E><K><I><R><L><M><V><S><G><S><A><A><L><P><L><P><V><L><E><K><W><K><N><I><T><G><H><T><L><L><E><R><Y><G><M><T><E><I><G><M><A><L><S><G><P><L><T><T><A><V><R><L><P><G><S><V><G><T><P><L><P><G><V><Q><V><R><I><V><S><E><N><P><Q><R><E><A><C><S><Y><T><I><H><A><E><G><D><E><R><G><T><K><V><T><P><G><F><E><E><K><E><G><E><L><L><V><R><G><P><S><V><F><R><E><Y><W><N><K><P><E><E><T><K><S><A><F><T><L><D><G><W><F><K><T><G><D><T><V><V><F><K><D><G><Q><Y><W><I><R><G><R><T><S><V><D><I><I><K><T><G><G><Y><K><V><S><A><L><E><V><E><W><H><L><L><A><H><P><S><I><T><D><V><A><V><I><G><V><P><D><M><T><W><G><Q><R><V><T><A><V><V><T><L><R><E><G><H><S><L><S><H><R><E><L><K><E><W><A><R><N><V><L><A><P><Y><A><V><P><S><E><L><V><L><V><E><E><I><P><R><N><Q><M><G><K><I><D><K><K><A><L><I><R><H><F><H><P><S>
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester . May have some preference toward very-long-chain substrates .<BOP>
Q4G176
Q5T686
AVPI1_HUMAN
Arginine vasopressin-induced protein 1
Homo
<M><G><T><P><A><S><V><V><S><E><P><P><P><W><Q><A><P><I><E><A><R><G><R><K><Q><A><S><A><N><I><F><Q><D><A><E><L><L><Q><I><Q><A><L><F><Q><R><S><G><D><Q><L><A><E><E><R><A><Q><I><I><W><E><C><A><G><D><H><R><V><A><E><A><L><K><R><L><R><R><K><R><P><P><R><Q><K><P><L><G><H><S><L><H><H><C><S><R><L><R><I><L><E><P><H><S><A><L><A><N><P><Q><S><A><T><E><T><A><S><S><E><Q><Y><L><H><S><R><K><K><S><A><R><I><R><R><N><W><R><K><S><G><P><T><S><Y><L><H><Q><I><R><H>
May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.<BOP>
Q5T686
O60383
GDF9_HUMAN
Growth/differentiation factor 9
Homo
<M><A><R><P><N><K><F><L><L><W><F><C><C><F><A><W><L><C><F><P><I><S><L><G><S><Q><A><S><G><G><E><A><Q><I><A><A><S><A><E><L><E><S><G><A><M><P><W><S><L><L><Q><H><I><D><E><R><D><R><A><G><L><L><P><A><L><F><K><V><L><S><V><G><R><G><G><S><P><R><L><Q><P><D><S><R><A><L><H><Y><M><K><K><L><Y><K><T><Y><A><T><K><E><G><I><P><K><S><N><R><S><H><L><Y><N><T><V><R><L><F><T><P><C><T><R><H><K><Q><A><P><G><D><Q><V><T><G><I><L><P><S><V><E><L><L><F><N><L><D><R><I><T><T><V><E><H><L><L><K><S><V><L><L><Y><N><I><N><N><S><V><S><F><S><S><A><V><K><C><V><C><N><L><M><I><K><E><P><K><S><S><S><R><T><L><G><R><A><P><Y><S><F><T><F><N><S><Q><F><E><F><G><K><K><H><K><W><I><Q><I><D><V><T><S><L><L><Q><P><L><V><A><S><N><K><R><S><I><H><M><S><I><N><F><T><C><M><K><D><Q><L><E><H><P><S><A><Q><N><G><L><F><N><M><T><L><V><S><P><S><L><I><L><Y><L><N><D><T><S><A><Q><A><Y><H><S><W><Y><S><L><H><Y><K><R><R><P><S><Q><G><P><D><Q><E><R><S><L><S><A><Y><P><V><G><E><E><A><A><E><D><G><R><S><S><H><H><R><H><R><R><G><Q><E><T><V><S><S><E><L><K><K><P><L><G><P><A><S><F><N><L><S><E><Y><F><R><Q><F><L><L><P><Q><N><E><C><E><L><H><D><F><R><L><S><F><S><Q><L><K><W><D><N><W><I><V><A><P><H><R><Y><N><P><R><Y><C><K><G><D><C><P><R><A><V><G><H><R><Y><G><S><P><V><H><T><M><V><Q><N><I><I><Y><E><K><L><D><S><S><V><P><R><P><S><C><V><P><A><K><Y><S><P><L><S><V><L><T><I><E><P><D><G><S><I><A><Y><K><E><Y><E><D><M><I><A><T><K><C><T><C><R>
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.<BOP>
O60383
P60006
APC15_HUMAN
Anaphase-promoting complex subunit 15
Homo
<M><S><T><L><F><P><S><L><F><P><R><V><T><E><T><L><W><F><N><L><D><R><P><C><V><E><E><T><E><L><Q><Q><Q><E><Q><Q><H><Q><A><W><L><Q><S><I><A><E><K><D><N><N><L><V><P><I><G><K><P><A><S><E><H><Y><D><D><E><E><E><E><D><D><E><D><D><E><D><S><E><E><D><S><E><D><D><E><D><M><Q><D><M><D><E><M><N><D><Y><N><E><S><P><D><D><G><E><V><N><E><V><D><M><E><G><N><E><Q><D><Q><D><Q><W><M><I>
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.<BOP>
P60006
P48147
PPCE_HUMAN
Post-proline cleaving enzyme
Homo
<M><L><S><L><Q><Y><P><D><V><Y><R><D><E><T><A><V><Q><D><Y><H><G><H><K><I><C><D><P><Y><A><W><L><E><D><P><D><S><E><Q><T><K><A><F><V><E><A><Q><N><K><I><T><V><P><F><L><E><Q><C><P><I><R><G><L><Y><K><E><R><M><T><E><L><Y><D><Y><P><K><Y><S><C><H><F><K><K><G><K><R><Y><F><Y><F><Y><N><T><G><L><Q><N><Q><R><V><L><Y><V><Q><D><S><L><E><G><E><A><R><V><F><L><D><P><N><I><L><S><D><D><G><T><V><A><L><R><G><Y><A><F><S><E><D><G><E><Y><F><A><Y><G><L><S><A><S><G><S><D><W><V><T><I><K><F><M><K><V><D><G><A><K><E><L><P><D><V><L><E><R><V><K><F><S><C><M><A><W><T><H><D><G><K><G><M><F><Y><N><S><Y><P><Q><Q><D><G><K><S><D><G><T><E><T><S><T><N><L><H><Q><K><L><Y><Y><H><V><L><G><T><D><Q><S><E><D><I><L><C><A><E><F><P><D><E><P><K><W><M><G><G><A><E><L><S><D><D><G><R><Y><V><L><L><S><I><R><E><G><C><D><P><V><N><R><L><W><Y><C><D><L><Q><Q><E><S><S><G><I><A><G><I><L><K><W><V><K><L><I><D><N><F><E><G><E><Y><D><Y><V><T><N><E><G><T><V><F><T><F><K><T><N><R><Q><S><P><N><Y><R><V><I><N><I><D><F><R><D><P><E><E><S><K><W><K><V><L><V><P><E><H><E><K><D><V><L><E><W><I><A><C><V><R><S><N><F><L><V><L><C><Y><L><H><D><V><K><N><I><L><Q><L><H><D><L><T><T><G><A><L><L><K><T><F><P><L><D><V><G><S><I><V><G><Y><S><G><Q><K><K><D><T><E><I><F><Y><Q><F><T><S><F><L><S><P><G><I><I><Y><H><C><D><L><T><K><E><E><L><E><P><R><V><F><R><E><V><T><V><K><G><I><D><A><S><D><Y><Q><T><V><Q><I><F><Y><P><S><K><D><G><T><K><I><P><M><F><I><V><H><K><K><G><I><K><L><D><G><S><H><P><A><F><L><Y><G><Y><G><G><F><N><I><S><I><T><P><N><Y><S><V><S><R><L><I><F><V><R><H><M><G><G><I><L><A><V><A><N><I><R><G><G><G><E><Y><G><E><T><W><H><K><G><G><I><L><A><N><K><Q><N><C><F><D><D><F><Q><C><A><A><E><Y><L><I><K><E><G><Y><T><S><P><K><R><L><T><I><N><G><G><S><N><G><G><L><L><V><A><A><C><A><N><Q><R><P><D><L><F><G><C><V><I><A><Q><V><G><V><M><D><M><L><K><F><H><K><Y><T><I><G><H><A><W><T><T><D><Y><G><C><S><D><S><K><Q><H><F><E><W><L><V><K><Y><S><P><L><H><N><V><K><L><P><E><A><D><D><I><Q><Y><P><S><M><L><L><L><T><A><D><H><D><D><R><V><V><P><L><H><S><L><K><F><I><A><T><L><Q><Y><I><V><G><R><S><R><K><Q><S><N><P><L><L><I><H><V><D><T><K><A><G><H><G><A><G><K><P><T><A><K><V><I><E><E><V><S><D><M><F><A><F><I><A><R><C><L><N><V><D><W><I><P>
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.<BOP>
P48147
Q9UGN4
CLM8_HUMAN
NK inhibitory receptor
Homo
<M><W><L><P><W><A><L><L><L><L><W><V><P><G><C><F><A><L><S><K><C><R><T><V><A><G><P><V><G><G><S><L><S><V><Q><C><P><Y><E><K><E><H><R><T><L><N><K><Y><W><C><R><P><P><Q><I><F><L><C><D><K><I><V><E><T><K><G><S><A><G><K><R><N><G><R><V><S><I><R><D><S><P><A><N><L><S><F><T><V><T><L><E><N><L><T><E><E><D><A><G><T><Y><W><C><G><V><D><T><P><W><L><R><D><F><H><D><P><V><V><E><V><E><V><S><V><F><P><A><S><T><S><M><T><P><A><S><I><T><A><A><K><T><S><T><I><T><T><A><F><P><P><V><S><S><T><T><L><F><A><V><G><A><T><H><S><A><S><I><Q><E><E><T><E><E><V><V><N><S><Q><L><P><L><L><L><S><L><L><A><L><L><L><L><L><L><V><G><A><S><L><L><A><W><R><M><F><Q><K><W><I><K><A><G><D><H><S><E><L><S><Q><N><P><K><Q><A><A><T><Q><S><E><L><H><Y><A><N><L><E><L><L><M><W><P><L><Q><E><K><P><A><P><P><R><E><V><E><V><E><Y><S><T><V><A><S><P><R><E><E><L><H><Y><A><S><V><V><F><D><S><N><T><N><R><I><A><A><Q><R><P><R><E><E><E><P><D><S><D><Y><S><V><I><R><K><T>
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 .<BOP>
Q9UGN4