accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P28908 | TNR8_HUMAN | Lymphocyte activation antigen CD30 | Homo | <M><R><V><L><L><A><A><L><G><L><L><F><L><G><A><L><R><A><F><P><Q><D><R><P><F><E><D><T><C><H><G><N><P><S><H><Y><Y><D><K><A><V><R><R><C><C><Y><R><C><P><M><G><L><F><P><T><Q><Q><C><P><Q><R><P><T><D><C><R><K><Q><C><E><P><D><Y><Y><L><D><E><A><D><R><C><T><A><C><V><T><C><S><R><D><D><L><V><E><K><T><P><C><A><W><N><S><S><R><V><C><E><C><R><P><G><M><F><C><S><T><S><A><V><N><S><C><A><R><C><F><F><H><S><V><C><P><A><G><M><I><V><K><F><P><G><T><A><Q><K><N><T><V><C><E><P><A><S><P><G><V><S><P><A><C><A><S><P><E><N><C><K><E><P><S><S><G><T><I><P><Q><A><K><P><T><P><V><S><P><A><T><S><S><A><S><T><M><P><V><R><G><G><T><R><L><A><Q><E><A><A><S><K><L><T><R><A><P><D><S><P><S><S><V><G><R><P><S><S><D><P><G><L><S><P><T><Q><P><C><P><E><G><S><G><D><C><R><K><Q><C><E><P><D><Y><Y><L><D><E><A><G><R><C><T><A><C><V><S><C><S><R><D><D><L><V><E><K><T><P><C><A><W><N><S><S><R><T><C><E><C><R><P><G><M><I><C><A><T><S><A><T><N><S><C><A><R><C><V><P><Y><P><I><C><A><A><E><T><V><T><K><P><Q><D><M><A><E><K><D><T><T><F><E><A><P><P><L><G><T><Q><P><D><C><N><P><T><P><E><N><G><E><A><P><A><S><T><S><P><T><Q><S><L><L><V><D><S><Q><A><S><K><T><L><P><I><P><T><S><A><P><V><A><L><S><S><T><G><K><P><V><L><D><A><G><P><V><L><F><W><V><I><L><V><L><V><V><V><V><G><S><S><A><F><L><L><C><H><R><R><A><C><R><K><R><I><R><Q><K><L><H><L><C><Y><P><V><Q><T><S><Q><P><K><L><E><L><V><D><S><R><P><R><R><S><S><T><Q><L><R><S><G><A><S><V><T><E><P><V><A><E><E><R><G><L><M><S><Q><P><L><M><E><T><C><H><S><V><G><A><A><Y><L><E><S><L><P><L><Q><D><A><S><P><A><G><G><P><S><S><P><R><D><L><P><E><P><R><V><S><T><E><H><T><N><N><K><I><E><K><I><Y><I><M><K><A><D><T><V><I><V><G><T><V><K><A><E><L><P><E><G><R><G><L><A><G><P><A><E><P><E><L><E><E><E><L><E><A><D><H><T><P><H><Y><P><E><Q><E><T><E><P><P><L><G><S><C><S><D><V><M><L><S><V><E><E><E><G><K><E><D><P><L><P><T><A><A><S><G><K> | Receptor for TNFSF8/CD30L . May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B .<BOP> | P28908 |
Q9BPZ3 | PAIP2_HUMAN | Polyadenylate-binding protein-interacting protein 2 | Homo | <M><K><D><P><S><R><S><S><T><S><P><S><I><I><N><E><D><V><I><I><N><G><H><S><H><E><D><D><N><P><F><A><E><Y><M><W><M><E><N><E><E><E><F><N><R><Q><I><E><E><E><L><W><E><E><E><F><I><E><R><C><F><Q><E><M><L><E><E><E><E><E><H><E><W><F><I><P><A><R><D><L><P><Q><T><M><D><Q><I><Q><D><Q><F><N><D><L><V><I><S><D><G><S><S><L><E><D><L><V><V><K><S><N><L><N><P><N><A><K><E><F><V><P><G><V><K><Y><G><N><I> | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.<BOP> | Q9BPZ3 |
O14950 | ML12B_HUMAN | SHUJUN-1 | Homo | <M><S><S><K><K><A><K><T><K><T><T><K><K><R><P><Q><R><A><T><S><N><V><F><A><M><F><D><Q><S><Q><I><Q><E><F><K><E><A><F><N><M><I><D><Q><N><R><D><G><F><I><D><K><E><D><L><H><D><M><L><A><S><L><G><K><N><P><T><D><A><Y><L><D><A><M><M><N><E><A><P><G><P><I><N><F><T><M><F><L><T><M><F><G><E><K><L><N><G><T><D><P><E><D><V><I><R><N><A><F><A><C><F><D><E><E><A><T><G><T><I><Q><E><D><Y><L><R><E><L><L><T><T><M><G><D><R><F><T><D><E><E><V><D><E><L><Y><R><E><A><P><I><D><K><K><G><N><F><N><Y><I><E><F><T><R><I><L><K><H><G><A><K><D><K><D><D> | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.<BOP> | O14950 |
Q9Y6E0 | STK24_HUMAN | Mammalian STE20-like protein kinase 3 C-terminal | Homo | <M><D><S><R><A><Q><L><W><G><L><A><L><N><K><R><R><A><T><L><P><H><P><G><G><S><T><N><L><K><A><D><P><E><E><L><F><T><K><L><E><K><I><G><K><G><S><F><G><E><V><F><K><G><I><D><N><R><T><Q><K><V><V><A><I><K><I><I><D><L><E><E><A><E><D><E><I><E><D><I><Q><Q><E><I><T><V><L><S><Q><C><D><S><P><Y><V><T><K><Y><Y><G><S><Y><L><K><D><T><K><L><W><I><I><M><E><Y><L><G><G><G><S><A><L><D><L><L><E><P><G><P><L><D><E><T><Q><I><A><T><I><L><R><E><I><L><K><G><L><D><Y><L><H><S><E><K><K><I><H><R><D><I><K><A><A><N><V><L><L><S><E><H><G><E><V><K><L><A><D><F><G><V><A><G><Q><L><T><D><T><Q><I><K><R><N><T><F><V><G><T><P><F><W><M><A><P><E><V><I><K><Q><S><A><Y><D><S><K><A><D><I><W><S><L><G><I><T><A><I><E><L><A><R><G><E><P><P><H><S><E><L><H><P><M><K><V><L><F><L><I><P><K><N><N><P><P><T><L><E><G><N><Y><S><K><P><L><K><E><F><V><E><A><C><L><N><K><E><P><S><F><R><P><T><A><K><E><L><L><K><H><K><F><I><L><R><N><A><K><K><T><S><Y><L><T><E><L><I><D><R><Y><K><R><W><K><A><E><Q><S><H><D><D><S><S><S><E><D><S><D><A><E><T><D><G><Q><A><S><G><G><S><D><S><G><D><W><I><F><T><I><R><E><K><D><P><K><N><L><E><N><G><A><L><Q><P><S><D><L><D><R><N><K><M><K><D><I><P><K><R><P><F><S><Q><C><L><S><T><I><I><S><P><L><F><A><E><L><K><E><K><S><Q><A><C><G><G><N><L><G><S><I><E><E><L><R><G><A><I><Y><L><A><E><E><A><C><P><G><I><S><D><T><M><V><A><Q><L><V><Q><R><L><Q><R><Y><S><L><S><G><G><G><T><S><S><H> | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation . Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<BOP> | Q9Y6E0 |
Q53H82 | LACB2_HUMAN | Beta-lactamase-like protein 2 | Homo | <M><A><A><V><L><Q><R><V><E><R><L><S><N><R><V><V><R><V><L><G><C><N><P><G><P><M><T><L><Q><G><T><N><T><Y><L><V><G><T><G><P><R><R><I><L><I><D><T><G><E><P><A><I><P><E><Y><I><S><C><L><K><Q><A><L><T><E><F><N><T><A><I><Q><E><I><V><V><T><H><W><H><R><D><H><S><G><G><I><G><D><I><C><K><S><I><N><N><D><T><T><Y><C><I><K><K><L><P><R><N><P><Q><R><E><E><I><I><G><N><G><E><Q><Q><Y><V><Y><L><K><D><G><D><V><I><K><T><E><G><A><T><L><R><V><L><Y><T><P><G><H><T><D><D><H><M><A><L><L><L><E><E><E><N><A><I><F><S><G><D><C><I><L><G><E><G><T><T><V><F><E><D><L><Y><D><Y><M><N><S><L><K><E><L><L><K><I><K><A><D><I><I><Y><P><G><H><G><P><V><I><H><N><A><E><A><K><I><Q><Q><Y><I><S><H><R><N><I><R><E><Q><Q><I><L><T><L><F><R><E><N><F><E><K><S><F><T><V><M><E><L><V><K><I><I><Y><K><N><T><P><E><N><L><H><E><M><A><K><H><N><L><L><L><H><L><K><K><L><E><K><E><G><K><I><F><S><N><T><D><P><D><K><K><W><K><A><H><L> | Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.<BOP> | Q53H82 |
O75689 | ADAP1_HUMAN | Putative MAPK-activating protein PM25 | Homo | <M><A><K><E><R><R><R><A><V><L><E><L><L><Q><R><P><G><N><A><R><C><A><D><C><G><A><P><D><P><D><W><A><S><Y><T><L><G><V><F><I><C><L><S><C><S><G><I><H><R><N><I><P><Q><V><S><K><V><K><S><V><R><L><D><A><W><E><E><A><Q><V><E><F><M><A><S><H><G><N><D><A><A><R><A><R><F><E><S><K><V><P><S><F><Y><Y><R><P><T><P><S><D><C><Q><L><L><R><E><Q><W><I><R><A><K><Y><E><R><Q><E><F><I><Y><P><E><K><Q><E><P><Y><S><A><G><Y><R><E><G><F><L><W><K><R><G><R><D><N><G><Q><F><L><S><R><K><F><V><L><T><E><R><E><G><A><L><K><Y><F><N><R><N><D><A><K><E><P><K><A><V><M><K><I><E><H><L><N><A><T><F><Q><P><A><K><I><G><H><P><H><G><L><Q><V><T><Y><L><K><D><N><S><T><R><N><I><F><I><Y><H><E><D><G><K><E><I><V><D><W><F><N><A><L><R><A><A><R><F><H><Y><L><Q><V><A><F><P><G><A><G><D><A><D><L><V><P><K><L><S><R><N><Y><L><K><E><G><Y><M><E><K><T><G><P><K><Q><T><E><G><F><R><K><R><W><F><T><M><D><D><R><R><L><M><Y><F><K><D><P><L><D><A><F><A><R><G><E><V><F><I><G><S><K><E><S><G><Y><T><V><L><H><G><F><P><P><S><T><Q><G><H><H><W><P><H><G><I><T><I><V><T><P><D><R><K><F><L><F><A><C><E><T><E><S><D><Q><R><E><W><V><A><A><F><Q><K><A><V><D><R><P><M><L><P><Q><E><Y><A><V><E><A><H><F><K><H><K><P> | GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).<BOP> | O75689 |
A0A1B0GX49 | TVB64_HUMAN | T cell receptor beta variable 6-4 | Homo | <M><S><I><R><L><L><C><C><V><A><F><S><L><L><W><A><G><P><V><T><A><G><I><T><Q><A><P><T><S><Q><I><L><A><A><G><R><S><M><T><L><R><C><T><Q><D><M><R><H><N><A><M><Y><W><Y><R><Q><D><L><G><L><G><L><R><L><I><H><Y><S><N><T><A><G><T><T><G><K><G><E><V><P><D><G><Y><S><V><S><R><A><N><T><D><D><F><P><L><T><L><A><S><A><V><P><S><Q><T><S><V><Y><F><C><A><S><S><D> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A1B0GX49 |
P31949 | S10AB_HUMAN | Protein S100-A11, N-terminally processed | Homo | <M><A><K><I><S><S><P><T><E><T><E><R><C><I><E><S><L><I><A><V><F><Q><K><Y><A><G><K><D><G><Y><N><Y><T><L><S><K><T><E><F><L><S><F><M><N><T><E><L><A><A><F><T><K><N><Q><K><D><P><G><V><L><D><R><M><M><K><K><L><D><T><N><S><D><G><Q><L><D><F><S><E><F><L><N><L><I><G><G><L><A><M><A><C><H><D><S><F><L><K><A><V><P><S><Q><K><R><T> | Facilitates the differentiation and the cornification of keratinocytes.<BOP> | P31949 |
Q9UHI5 | LAT2_HUMAN | Solute carrier family 7 member 8 | Homo | <M><E><E><G><A><R><H><R><N><N><T><E><K><K><H><P><G><G><G><E><S><D><A><S><P><E><A><G><S><G><G><G><G><V><A><L><K><K><E><I><G><L><V><S><A><C><G><I><I><V><G><N><I><I><G><S><G><I><F><V><S><P><K><G><V><L><E><N><A><G><S><V><G><L><A><L><I><V><W><I><V><T><G><F><I><T><V><V><G><A><L><C><Y><A><E><L><G><V><T><I><P><K><S><G><G><D><Y><S><Y><V><K><D><I><F><G><G><L><A><G><F><L><R><L><W><I><A><V><L><V><I><Y><P><T><N><Q><A><V><I><A><L><T><F><S><N><Y><V><L><Q><P><L><F><P><T><C><F><P><P><E><S><G><L><R><L><L><A><A><I><C><L><L><L><L><T><W><V><N><C><S><S><V><R><W><A><T><R><V><Q><D><I><F><T><A><G><K><L><L><A><L><A><L><I><I><I><M><G><I><V><Q><I><C><K><G><E><Y><F><W><L><E><P><K><N><A><F><E><N><F><Q><E><P><D><I><G><L><V><A><L><A><F><L><Q><G><S><F><A><Y><G><G><W><N><F><L><N><Y><V><T><E><E><L><V><D><P><Y><K><N><L><P><R><A><I><F><I><S><I><P><L><V><T><F><V><Y><V><F><A><N><V><A><Y><V><T><A><M><S><P><Q><E><L><L><A><S><N><A><V><A><V><T><F><G><E><K><L><L><G><V><M><A><W><I><M><P><I><S><V><A><L><S><T><F><G><G><V><N><G><S><L><F><T><S><S><R><L><F><F><A><G><A><R><E><G><H><L><P><S><V><L><A><M><I><H><V><K><R><C><T><P><I><P><A><L><L><F><T><C><I><S><T><L><L><M><L><V><T><S><D><M><Y><T><L><I><N><Y><V><G><F><I><N><Y><L><F><Y><G><V><T><V><A><G><Q><I><V><L><R><W><K><K><P><D><I><P><R><P><I><K><I><N><L><L><F><P><I><I><Y><L><L><F><W><A><F><L><L><V><F><S><L><W><S><E><P><V><V><C><G><I><G><L><A><I><M><L><T><G><V><P><V><Y><F><L><G><V><Y><W><Q><H><K><P><K><C><F><S><D><F><I><E><L><L><T><L><V><S><Q><K><M><C><V><V><V><Y><P><E><V><E><R><G><S><G><T><E><E><A><N><E><D><M><E><E><Q><Q><Q><P><M><Y><Q><P><T><P><T><K><D><K><D><V><A><G><Q><P><Q><P> | Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.<BOP> | Q9UHI5 |
P29373 | RABP2_HUMAN | Cellular retinoic acid-binding protein II | Homo | <M><P><N><F><S><G><N><W><K><I><I><R><S><E><N><F><E><E><L><L><K><V><L><G><V><N><V><M><L><R><K><I><A><V><A><A><A><S><K><P><A><V><E><I><K><Q><E><G><D><T><F><Y><I><K><T><S><T><T><V><R><T><T><E><I><N><F><K><V><G><E><E><F><E><E><Q><T><V><D><G><R><P><C><K><S><L><V><K><W><E><S><E><N><K><M><V><C><E><Q><K><L><L><K><G><E><G><P><K><T><S><W><T><R><E><L><T><N><D><G><E><L><I><L><T><M><T><A><D><D><V><V><C><T><R><V><Y><V><R><E> | Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.<BOP> | P29373 |
Q9BQ90 | KLDC3_HUMAN | Testis intracellular mediator protein | Homo | <M><L><R><W><T><V><H><L><E><G><G><P><R><R><V><N><H><A><A><V><A><V><G><H><R><V><Y><S><F><G><G><Y><C><S><G><E><D><Y><E><T><L><R><Q><I><D><V><H><I><F><N><A><V><S><L><R><W><T><K><L><P><P><V><K><S><A><I><R><G><Q><A><P><V><V><P><Y><M><R><Y><G><H><S><T><V><L><I><D><D><T><V><L><L><W><G><G><R><N><D><T><E><G><A><C><N><V><L><Y><A><F><D><V><N><T><H><K><W><F><T><P><R><V><S><G><T><V><P><G><A><R><D><G><H><S><A><C><V><L><G><K><I><M><Y><I><F><G><G><Y><E><Q><Q><A><D><C><F><S><N><D><I><H><K><L><D><T><S><T><M><T><W><T><L><I><C><T><K><G><S><P><A><R><W><R><D><F><H><S><A><T><M><L><G><S><H><M><Y><V><F><G><G><R><A><D><R><F><G><P><F><H><S><N><N><E><I><Y><C><N><R><I><R><V><F><D><T><R><T><E><A><W><L><D><C><P><P><T><P><V><L><P><E><G><R><R><S><H><S><A><F><G><Y><N><G><E><L><Y><I><F><G><G><Y><N><A><R><L><N><R><H><F><H><D><L><W><K><F><N><P><V><S><F><T><W><K><K><I><E><P><K><G><K><G><P><C><P><R><R><R><Q><C><C><C><I><V><G><D><K><I><V><L><F><G><G><T><S><P><S><P><E><E><G><L><G><D><E><F><D><L><I><D><H><S><D><L><H><I><L><D><F><S><P><S><L><K><T><L><C><K><L><A><V><I><Q><Y><N><L><D><Q><S><C><L><P><H><D><I><R><W><E><L><N><A><M><T><T><N><S><N><I><S><R><P><I><V><S><S><H><G> | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons . The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine . May be involved in meiotic recombination process .<BOP> | Q9BQ90 |
Q8N4P3 | MESH1_HUMAN | Penta-phosphate guanosine-3'-pyrophosphohydrolase | Homo | <M><G><S><E><A><A><Q><L><L><E><A><A><D><F><A><A><R><K><H><R><Q><Q><R><R><K><D><P><E><G><T><P><Y><I><N><H><P><I><G><V><A><R><I><L><T><H><E><A><G><I><T><D><I><V><V><L><Q><A><A><L><L><H><D><T><V><E><D><T><D><T><T><L><D><E><V><E><L><H><F><G><A><Q><V><R><R><L><V><E><E><V><T><D><D><K><T><L><P><K><L><E><R><K><R><L><Q><V><E><Q><A><P><H><S><S><P><G><A><K><L><V><K><L><A><D><K><L><Y><N><L><R><D><L><N><R><C><T><P><E><G><W><S><E><H><R><V><Q><E><Y><F><E><W><A><A><Q><V><V><K><G><L><Q><G><T><N><R><Q><L><E><E><A><L><K><H><L><F><K><Q><R><G><L><T><I> | ppGpp hydrolyzing enzyme involved in starvation response.<BOP> | Q8N4P3 |
Q7Z4H4 | ADM2_HUMAN | Intermedin-short | Homo | <M><A><R><I><P><T><A><A><L><G><C><I><S><L><L><C><L><Q><L><P><G><S><L><S><R><S><L><G><G><D><P><R><P><V><K><P><R><E><P><P><A><R><S><P><S><S><S><L><Q><P><R><H><P><A><P><R><P><V><V><W><K><L><H><R><A><L><Q><A><Q><R><G><A><G><L><A><P><V><M><G><Q><P><L><R><D><G><G><R><Q><H><S><G><P><R><R><H><S><G><P><R><R><T><Q><A><Q><L><L><R><V><G><C><V><L><G><T><C><Q><V><Q><N><L><S><H><R><L><W><Q><L><M><G><P><A><G><R><Q><D><S><A><P><V><D><P><S><S><P><H><S><Y><G> | May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.<BOP> | Q7Z4H4 |
P38571 | LICH_HUMAN | Sterol esterase | Homo | <M><K><M><R><F><L><G><L><V><V><C><L><V><L><W><T><L><H><S><E><G><S><G><G><K><L><T><A><V><D><P><E><T><N><M><N><V><S><E><I><I><S><Y><W><G><F><P><S><E><E><Y><L><V><E><T><E><D><G><Y><I><L><C><L><N><R><I><P><H><G><R><K><N><H><S><D><K><G><P><K><P><V><V><F><L><Q><H><G><L><L><A><D><S><S><N><W><V><T><N><L><A><N><S><S><L><G><F><I><L><A><D><A><G><F><D><V><W><M><G><N><S><R><G><N><T><W><S><R><K><H><K><T><L><S><V><S><Q><D><E><F><W><A><F><S><Y><D><E><M><A><K><Y><D><L><P><A><S><I><N><F><I><L><N><K><T><G><Q><E><Q><V><Y><Y><V><G><H><S><Q><G><T><T><I><G><F><I><A><F><S><Q><I><P><E><L><A><K><R><I><K><M><F><F><A><L><G><P><V><A><S><V><A><F><C><T><S><P><M><A><K><L><G><R><L><P><D><H><L><I><K><D><L><F><G><D><K><E><F><L><P><Q><S><A><F><L><K><W><L><G><T><H><V><C><T><H><V><I><L><K><E><L><C><G><N><L><C><F><L><L><C><G><F><N><E><R><N><L><N><M><S><R><V><D><V><Y><T><T><H><S><P><A><G><T><S><V><Q><N><M><L><H><W><S><Q><A><V><K><F><Q><K><F><Q><A><F><D><W><G><S><S><A><K><N><Y><F><H><Y><N><Q><S><Y><P><P><T><Y><N><V><K><D><M><L><V><P><T><A><V><W><S><G><G><H><D><W><L><A><D><V><Y><D><V><N><I><L><L><T><Q><I><T><N><L><V><F><H><E><S><I><P><E><W><E><H><L><D><F><I><W><G><L><D><A><P><W><R><L><Y><N><K><I><I><N><L><M><R><K><Y><Q> | Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.<BOP> | P38571 |
O14718 | OPSX_HUMAN | Visual pigment-like receptor peropsin | Homo | <M><L><R><N><N><L><G><N><S><S><D><S><K><N><E><D><G><S><V><F><S><Q><T><E><H><N><I><V><A><T><Y><L><I><M><A><G><M><I><S><I><I><S><N><I><I><V><L><G><I><F><I><K><Y><K><E><L><R><T><P><T><N><A><I><I><I><N><L><A><V><T><D><I><G><V><S><S><I><G><Y><P><M><S><A><A><S><D><L><Y><G><S><W><K><F><G><Y><A><G><C><Q><V><Y><A><G><L><N><I><F><F><G><M><A><S><I><G><L><L><T><V><V><A><V><D><R><Y><L><T><I><C><L><P><D><V><G><R><R><M><T><T><N><T><Y><I><G><L><I><L><G><A><W><I><N><G><L><F><W><A><L><M><P><I><I><G><W><A><S><Y><A><P><D><P><T><G><A><T><C><T><I><N><W><R><K><N><D><R><S><F><V><S><Y><T><M><T><V><I><A><I><N><F><I><V><P><L><T><V><M><F><Y><C><Y><Y><H><V><T><L><S><I><K><H><H><T><T><S><D><C><T><E><S><L><N><R><D><W><S><D><Q><I><D><V><T><K><M><S><V><I><M><I><C><M><F><L><V><A><W><S><P><Y><S><I><V><C><L><W><A><S><F><G><D><P><K><K><I><P><P><P><M><A><I><I><A><P><L><F><A><K><S><S><T><F><Y><N><P><C><I><Y><V><V><A><N><K><K><F><R><R><A><M><L><A><M><F><K><C><Q><T><H><Q><T><M><P><V><T><S><I><L><P><M><D><V><S><Q><N><P><L><A><S><G><R><I> | May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.<BOP> | O14718 |
P54105 | ICLN_HUMAN | Reticulocyte pICln | Homo | <M><S><F><L><K><S><F><P><P><P><G><P><A><E><G><L><L><R><Q><Q><P><D><T><E><A><V><L><N><G><K><G><L><G><T><G><T><L><Y><I><A><E><S><R><L><S><W><L><D><G><S><G><L><G><F><S><L><E><Y><P><T><I><S><L><H><A><L><S><R><D><R><S><D><C><L><G><E><H><L><Y><V><M><V><N><A><K><F><E><E><E><S><K><E><P><V><A><D><E><E><E><E><D><S><D><D><D><V><E><P><I><T><E><F><R><F><V><P><S><D><K><S><A><L><E><A><M><F><T><A><M><C><E><C><Q><A><L><H><P><D><P><E><D><E><D><S><D><D><Y><D><G><E><E><Y><D><V><E><A><H><E><Q><G><Q><G><D><I><P><T><F><Y><T><Y><E><E><G><L><S><H><L><T><A><E><G><Q><A><T><L><E><R><L><E><G><M><L><S><Q><S><V><S><S><Q><Y><N><M><A><G><V><R><T><E><D><S><I><R><D><Y><E><D><G><M><E><V><D><T><T><P><T><V><A><G><Q><F><E><D><A><D><V><D><H> | Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins . Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs . Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) . In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP . Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport | P54105 |
Q01638 | ILRL1_HUMAN | Protein ST2 | Homo | <M><G><F><W><I><L><A><I><L><T><I><L><M><Y><S><T><A><A><K><F><S><K><Q><S><W><G><L><E><N><E><A><L><I><V><R><C><P><R><Q><G><K><P><S><Y><T><V><D><W><Y><Y><S><Q><T><N><K><S><I><P><T><Q><E><R><N><R><V><F><A><S><G><Q><L><L><K><F><L><P><A><A><V><A><D><S><G><I><Y><T><C><I><V><R><S><P><T><F><N><R><T><G><Y><A><N><V><T><I><Y><K><K><Q><S><D><C><N><V><P><D><Y><L><M><Y><S><T><V><S><G><S><E><K><N><S><K><I><Y><C><P><T><I><D><L><Y><N><W><T><A><P><L><E><W><F><K><N><C><Q><A><L><Q><G><S><R><Y><R><A><H><K><S><F><L><V><I><D><N><V><M><T><E><D><A><G><D><Y><T><C><K><F><I><H><N><E><N><G><A><N><Y><S><V><T><A><T><R><S><F><T><V><K><D><E><Q><G><F><S><L><F><P><V><I><G><A><P><A><Q><N><E><I><K><E><V><E><I><G><K><N><A><N><L><T><C><S><A><C><F><G><K><G><T><Q><F><L><A><A><V><L><W><Q><L><N><G><T><K><I><T><D><F><G><E><P><R><I><Q><Q><E><E><G><Q><N><Q><S><F><S><N><G><L><A><C><L><D><M><V><L><R><I><A><D><V><K><E><E><D><L><L><L><Q><Y><D><C><L><A><L><N><L><H><G><L><R><R><H><T><V><R><L><S><R><K><N><P><I><D><H><H><S><I><Y><C><I><I><A><V><C><S><V><F><L><M><L><I><N><V><L><V><I><I><L><K><M><F><W><I><E><A><T><L><L><W><R><D><I><A><K><P><Y><K><T><R><N><D><G><K><L><Y><D><A><Y><V><V><Y><P><R><N><Y><K><S><S><T><D><G><A><S><R><V><E><H><F><V><H><Q><I><L><P><D><V><L><E><N><K><C><G><Y><T><L><C><I><Y><G><R><D><M><L><P><G><E><D><V><V><T><A><V><E><T><N><I><R><K><S><R><R><H><I><F><I><L><T><P><Q><I><T><H><N><K><E><F><A><Y><E><Q><E><V><A><L><H><C><A><L><I><Q><N><D><A><K><V><I><L><I><E><M><E><A><L><S><E><L><D><M><L><Q><A><E><A><L><Q><D><S><L><Q><H><L><M><K><V><Q><G><T><I><K><W><R><E><D><H><I><A><N><K><R><S><L><N><S><K><F><W><K><H><V><R><Y><Q><M><P><V><P><S><K><I><P><R><K><A><S><S><L><T><P><L><A><A><Q><K><Q> | Inhibits IL-33 signaling.<BOP> | Q01638 |
Q9P270 | SLAI2_HUMAN | SLAIN motif-containing protein 2 | Homo | <M><E><D><V><N><S><N><V><N><A><D><Q><E><V><R><K><L><Q><E><L><V><K><K><L><E><K><Q><N><E><Q><L><R><S><R><S><G><A><V><Q><G><A><G><S><L><G><P><G><S><P><V><R><A><G><A><S><I><P><S><S><G><A><A><S><P><R><G><F><P><L><G><L><S><A><K><S><G><G><G><P><G><S><G><P><R><R><T><S><S><E><E><L><R><D><A><T><S><L><L><A><A><G><E><G><G><L><L><D><E><V><E><P><L><R><P><D><E><L><E><R><L><S><G><W><E><E><E><E><E><S><W><L><Y><S><S><P><K><K><K><L><T><P><M><Q><K><S><V><S><P><L><V><W><C><R><Q><V><L><D><Y><P><S><P><D><V><E><C><A><K><K><S><L><I><H><K><L><D><Q><T><M><S><A><L><K><R><Q><N><L><Y><N><N><P><F><N><S><M><S><Y><T><S><P><Y><S><P><N><A><S><S><P><Y><S><S><G><F><N><S><P><S><S><T><P><V><R><P><P><I><V><K><Q><L><I><L><P><G><N><S><G><N><L><K><S><S><D><R><N><P><P><L><S><P><Q><S><S><I><D><S><E><L><S><A><S><E><L><D><E><D><S><I><G><S><N><Y><K><L><N><D><V><T><D><V><Q><I><L><A><R><M><Q><E><E><S><L><R><Q><E><Y><A><A><T><T><S><R><R><S><S><G><S><S><C><N><S><T><R><R><G><T><F><S><D><Q><E><L><D><A><Q><S><L><D><D><E><D><D><N><M><H><H><A><V><Y><P><A><V><N><R><F><S><P><S><P><R><N><S><P><R><P><S><P><K><Q><S><P><R><N><S><P><R><S><R><S><P><A><R><G><I><E><Y><S><R><V><S><P><Q><P><M><I><S><R><L><Q><Q><P><R><L><S><L><Q><G><H><P><T><D><L><Q><T><S><N><V><K><N><E><E><K><L><R><R><S><L><P><N><L><S><R><T><S><N><T><Q><V><D><S><V><K><S><S><R><S><D><S><N><F><Q><V><P><N><G><G><I><P><R><M><Q><P><Q><A><S><A><I><P><S><P><G><K><F><R><S><P><A><A><P><S><P><L><A><L><R><Q><P><V><K><A><F><S><N><H><G><S><G><S><P><G><S><Q><E><I><T><Q><L><T><Q><T><T><S><S><P><G><P><P><M><V><Q><S><T><V><S><A><N><P><P><S><N><I><N><S><A><T><L><T><R><P><A><G><T><T><A><M><R><S><G><L><P><R><P><S><A><P><S><A><G><G><I><P><V><P><R><S><K><L><A><Q><P><V><R><R><S><L><P><A><P><K><T><Y><G><S><M><K><D><D><S><W><K><D><G><C><Y> | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.<BOP> | Q9P270 |
Q99929 | ASCL2_HUMAN | Mash2 | Homo | <M><D><G><G><T><L><P><R><S><A><P><P><A><P><P><V><P><V><G><C><A><A><R><R><R><P><A><S><P><E><L><L><R><C><S><R><R><R><R><P><A><T><A><E><T><G><G><G><A><A><A><V><A><R><R><N><E><R><E><R><N><R><V><K><L><V><N><L><G><F><Q><A><L><R><Q><H><V><P><H><G><G><A><S><K><K><L><S><K><V><E><T><L><R><S><A><V><E><Y><I><R><A><L><Q><R><L><L><A><E><H><D><A><V><R><N><A><L><A><G><G><L><R><P><Q><A><V><R><P><S><A><P><R><G><P><P><G><T><T><P><V><A><A><S><P><S><R><A><S><S><S><P><G><R><G><G><S><S><E><P><G><S><P><R><S><A><Y><S><S><D><D><S><G><C><E><G><A><L><S><P><A><E><R><E><L><L><D><F><S><S><W><L><G><G><Y> | AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.<BOP> | Q99929 |
Q0VDF9 | HSP7E_HUMAN | Heat shock protein HSP60 | Homo | <M><A><A><I><G><V><H><L><G><C><T><S><A><C><V><A><V><Y><K><D><G><R><A><G><V><V><A><N><D><A><G><D><R><V><T><P><A><V><V><A><Y><S><E><N><E><E><I><V><G><L><A><A><K><Q><S><R><I><R><N><I><S><N><T><V><M><K><V><K><Q><I><L><G><R><S><S><S><D><P><Q><A><Q><K><Y><I><A><E><S><K><C><L><V><I><E><K><N><G><K><L><R><Y><E><I><D><T><G><E><E><T><K><F><V><N><P><E><D><V><A><R><L><I><F><S><K><M><K><E><T><A><H><S><V><L><G><S><D><A><N><D><V><V><I><T><V><P><F><D><F><G><E><K><Q><K><N><A><L><G><E><A><A><R><A><A><G><F><N><V><L><R><L><I><H><E><P><S><A><A><L><L><A><Y><G><I><G><Q><D><S><P><T><G><K><S><N><I><L><V><F><K><L><G><G><T><S><L><S><L><S><V><M><E><V><N><S><G><I><Y><R><V><L><S><T><N><T><D><D><N><I><G><G><A><H><F><T><E><T><L><A><Q><Y><L><A><S><E><F><Q><R><S><F><K><H><D><V><R><G><N><A><R><A><M><M><K><L><T><N><S><A><E><V><A><K><H><S><L><S><T><L><G><S><A><N><C><F><L><D><S><L><Y><E><G><Q><D><F><D><C><N><V><S><R><A><R><F><E><L><L><C><S><P><L><F><N><K><C><I><E><A><I><R><G><L><L><D><Q><N><G><F><T><A><D><D><I><N><K><V><V><L><C><G><G><S><S><R><I><P><K><L><Q><Q><L><I><K><D><L><F><P><A><V><E><L><L><N><S><I><P><P><D><E><V><I><P><I><G><A><A><I><E><A><G><I><L><I><G><K><E><N><L><L><V><E><D><S><L><M><I><E><C><S><A><R><D><I><L><V><K><G><V><D><E><S><G><A><S><R><F><T><V><L><F><P><S><G><T><P><L><P><A><R><R><Q><H><T><L><Q><A><P><G><S><I><S><S><V><C><L><E><L><Y><E><S><D><G><K><N><S><A><K><E><E><T><K><F><A><Q><V><V><L><Q><D><L><D><K><K><E><N><G><L><R><D><I><L><A><V><L><T><M><K><R><D><G><S><L><H><V><T><C><T><D><Q><E><T><G><K><C><E><A><I><S><I><E><I><A><S> | Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.<BOP> | Q0VDF9 |
Q8NH48 | OR5B3_HUMAN | Olfactory receptor OR11-239 | Homo | <M><E><N><K><T><E><V><T><Q><F><I><L><L><G><L><T><N><D><S><E><L><Q><V><P><L><F><I><T><F><P><F><I><Y><I><I><T><L><V><G><N><L><G><I><I><V><L><I><F><W><D><S><C><L><H><N><P><M><Y><F><F><L><S><N><L><S><L><V><D><F><C><Y><S><S><A><V><T><P><I><V><M><A><G><F><L><I><E><D><K><V><I><S><Y><N><A><C><A><A><Q><M><Y><I><F><V><A><F><A><T><V><E><N><Y><L><L><A><S><M><A><Y><D><R><Y><A><A><V><C><K><P><L><H><Y><T><T><T><M><T><T><T><V><C><A><R><L><A><I><G><S><Y><L><C><G><F><L><N><A><S><I><H><T><G><D><T><F><S><L><S><F><C><K><S><N><E><V><H><H><F><F><C><D><I><P><A><V><M><V><L><S><C><S><D><R><H><I><S><E><L><V><L><I><Y><V><V><S><F><N><I><F><I><A><L><L><V><I><L><I><S><Y><T><F><I><F><I><T><I><L><K><M><H><S><A><S><V><Y><Q><K><P><L><S><T><C><A><S><H><F><I><A><V><G><I><F><Y><G><T><I><I><F><M><Y><L><Q><P><S><S><S><H><S><M><D><T><D><K><M><A><P><V><F><Y><T><M><V><I><P><M><L><N><P><L><V><Y><S><L><R><N><K><E><V><K><S><A><F><K><K><V><V><E><K><A><K><L><S><V><G><W><S><V> | Odorant receptor.<BOP> | Q8NH48 |
A0A0J9YX75 | TVB69_HUMAN | T cell receptor beta variable 6-9 | Homo | <M><S><I><G><L><L><C><C><V><A><F><S><L><L><W><A><G><P><V><N><A><G><V><T><Q><T><P><K><F><H><I><L><K><T><G><Q><S><M><T><L><Q><C><A><Q><D><M><N><H><G><Y><L><S><W><Y><R><Q><D><P><G><M><G><L><R><R><I><H><Y><S><V><A><A><G><I><T><D><K><G><E><V><P><D><G><Y><N><V><S><R><S><N><T><E><D><F><P><L><R><L><E><S><A><A><P><S><Q><T><S><V><Y><F><C><A><S><S><Y> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0J9YX75 |
Q502X0 | MORN2_HUMAN | MORN motif protein in testis | Homo | <M><N><G><F><G><R><L><E><H><F><S><G><A><V><Y><E><G><Q><F><K><D><N><M><F><H><G><L><G><T><Y><T><F><P><N><G><A><K><Y><T><G><N><F><N><E><N><R><V><E><G><E><G><E><Y><T><D><I><Q><G><L><E><W><S><G><N><F><H><F><T><A><A><P><D><L><K><L><K><L><H><M> | Might have a role in spermatogenesis.<BOP> | Q502X0 |
Q5GJ75 | TP8L3_HUMAN | Tumor necrosis factor alpha-induced protein 8-like protein 3 | Homo | <M><G><K><P><R><Q><N><P><S><T><L><V><S><T><L><C><E><A><E><P><K><G><K><L><W><V><N><G><Y><A><G><T><Q><G><T><R><D><A><T><L><Q><T><R><L><I><P><L><S><F><H><L><Q><R><G><K><G><L><A><A><P><L><S><A><L><S><A><P><R><L><P><E><R><P><A><D><G><R><V><A><V><D><A><Q><P><A><A><R><S><M><D><S><D><S><G><E><Q><S><E><G><E><P><V><T><A><A><G><P><D><V><F><S><S><K><S><L><A><L><Q><A><Q><K><K><I><L><S><K><I><A><S><K><T><V><A><N><M><L><I><D><D><T><S><S><E><I><F><D><E><L><Y><K><V><T><K><E><H><T><H><N><K><K><E><A><H><K><I><M><K><D><L><I><K><V><A><I><K><I><G><I><L><Y><R><N><N><Q><F><S><Q><E><E><L><V><I><V><E><K><F><R><K><K><L><N><Q><T><A><M><T><I><V><S><F><Y><E><V><E><Y><T><F><D><R><N><V><L><S><N><L><L><H><E><C><K><D><L><V><H><E><L><V><Q><R><H><L><T><P><R><T><H><G><R><I><N><H><V><F><N><H><F><A><D><V><E><F><L><S><T><L><Y><S><L><D><G><D><C><R><P><N><L><K><R><I><C><E><G><I><N><K><L><L><D><E><K><V><L> | Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.<BOP> | Q5GJ75 |
Q00325 | MPCP_HUMAN | Solute carrier family 25 member 3 | Homo | <M><F><S><S><V><A><H><L><A><R><A><N><P><F><N><T><P><H><L><Q><L><V><H><D><G><L><G><D><L><R><S><S><S><P><G><P><T><G><Q><P><R><R><P><R><N><L><A><A><A><A><V><E><E><Q><Y><S><C><D><Y><G><S><G><R><F><F><I><L><C><G><L><G><G><I><I><S><C><G><T><T><H><T><A><L><V><P><L><D><L><V><K><C><R><M><Q><V><D><P><Q><K><Y><K><G><I><F><N><G><F><S><V><T><L><K><E><D><G><V><R><G><L><A><K><G><W><A><P><T><F><L><G><Y><S><M><Q><G><L><C><K><F><G><F><Y><E><V><F><K><V><L><Y><S><N><M><L><G><E><E><N><T><Y><L><W><R><T><S><L><Y><L><A><A><S><A><S><A><E><F><F><A><D><I><A><L><A><P><M><E><A><A><K><V><R><I><Q><T><Q><P><G><Y><A><N><T><L><R><D><A><A><P><K><M><Y><K><E><E><G><L><K><A><F><Y><K><G><V><A><P><L><W><M><R><Q><I><P><Y><T><M><M><K><F><A><C><F><E><R><T><V><E><A><L><Y><K><F><V><V><P><K><P><R><S><E><C><S><K><P><E><Q><L><V><V><T><F><V><A><G><Y><I><A><G><V><F><C><A><I><V><S><H><P><A><D><S><V><V><S><V><L><N><K><E><K><G><S><S><A><S><L><V><L><K><R><L><G><F><K><G><V><W><K><G><L><F><A><R><I><I><M><I><G><T><L><T><A><L><Q><W><F><I><Y><D><S><V><K><V><Y><F><R><L><P><R><P><P><P><P><E><M><P><E><S><L><K><K><K><L><G><L><T><Q> | Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).<BOP> | Q00325 |
A6NNF4 | ZN726_HUMAN | Zinc finger protein 726 | Homo | <M><G><L><L><T><F><R><D><V><A><I><E><F><S><L><E><E><W><Q><C><L><D><T><A><Q><K><N><L><Y><R><N><V><M><L><E><N><Y><R><N><L><A><F><L><G><I><A><V><S><K><P><D><L><I><I><C><L><E><K><E><K><E><P><W><N><M><K><R><D><E><M><V><D><E><P><P><G><I><C><P><H><F><A><Q><D><I><W><P><E><Q><G><V><E><D><S><F><Q><K><V><I><L><R><R><F><E><K><C><G><H><E><N><L><Q><L><R><K><G><C><K><S><V><D><E><C><K><V><H><K><E><G><Y><N><G><L><N><Q><C><F><T><T><T><Q><G><K><A><S><Q><C><G><K><Y><L><K><V><F><Y><K><F><I><N><L><N><R><Y><K><I><R><H><T><R><K><K><P><F><K><C><K><N><C><V><K><S><F><C><M><F><S><H><K><T><Q><H><K><S><I><Y><T><T><E><K><S><Y><K><C><K><E><C><G><K><T><F><N><W><S><S><T><L><T><N><H><K><K><T><H><T><E><E><K><P><Y><K><C><E><E><Y><G><K><A><F><N><Q><S><S><N><Y><T><T><H><K><V><T><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><Q><S><S><T><L><T><I><H><K><R><I><H><T><G><E><K><P><C><K><C><E><E><C><G><K><A><F><S><Q><P><S><A><L><T><I><H><K><R><M><H><I><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><V><W><S><S><T><L><T><R><H><K><R><L><H><S><G><E><K><P><Y><K><C><E><E><C><A><K><A><F><S><Q><F><G><H><L><T><T><H><R><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><I><W><P><S><T><L><T><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><H><R><S><S><N><L><T><K><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><I><W><S><S><N><L><T><E><H><K><K><I><H><T><R><E><K><P><Y><K><C><E><E><C><S><K><A><F><S><R><S><S><A><L><T><T><H><K><R><M><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><S><Q><S><S><T><L><T><A><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><I><L><S><S><T><L><S><K><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><T><F><N><Q><S><S><N><L><S><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><N><L><S><T><H><K><I><I><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><S><F><I><W><S><S><T><L><F><K><H><K><R><I><H><T> | May be involved in transcriptional regulation.<BOP> | A6NNF4 |
O60774 | FMO6_HUMAN | Flavin-containing monooxygenase 6 | Homo | <M><S><K><R><V><G><I><I><G><A><G><V><S><G><L><A><A><I><W><C><C><L><E><E><G><L><E><P><T><C><F><E><R><S><D><D><V><G><G><L><W><K><F><S><D><H><T><E><E><G><R><A><S><I><Y><Q><S><V><F><T><N><S><S><K><E><M><M><C><F><P><D><F><P><Y><P><D><D><Y><P><N><Y><I><H><H><S><K><L><Q><E><Y><I><K><T><Y><A><Q><K><K><D><L><L><R><Y><I><Q><F><E><T><L><V><S><G><I><K><K><C><P><S><F><L><V><T><G><Q><W><V><V><V><T><E><K><D><G><K><Q><E><S><T><I><F><D><A><V><M><I><C><S><G><H><H><V><Y><P><N><L><P><T><D><S><F><P><G><L><D><Q><F><R><G><N><Y><L><H><S><R><D><Y><K><N><P><E><A><F><K><G><K><R><V><L><V><I><G><L><G><N><S><G><S><D><I><A><V><E><L><S><R><L><A><T><Q><V><I><I><S><T><R><S><A><S><W><V><M><S><R><V><W><D><D><G><Y><P><W><D><M><M><Y><V><T><R><F><A><S><F><L><R><N><V><L><P><S><F><I><S><D><W><L><Y><V><Q><K><M><N><T><W><F><K><H><E><N><Y><G><L><M><P><L><N><G><S><L><R><K><E><P><V><F><N><D><E><L><P><S><R><I><L><C><G><T><L><S><I><K><P><S><V><K><E><F><T><E><T><S><A><V><F><E><D><G><T><M><F><E><A><I><D><S><V><I><F><A><T><G><Y><D><Y><S><Y><P><F><L><D><E><T><I><M><K><S><R><N><N><E><V><T><L><F><K><G><I><F><P><P><L><M><E><K><P><T><L><A><V><I><G><L><V><Q><S><L><G><A><A><I><P><T><A><D><L><Q><A><W><W><A><A><K><V><F><A><N><S><C><T><L><P><T><T><N><E><M><M><D><D><T><D><E><K><M><G><K><K><L><K><C><M><F><S><S><F><F><M><F><G><Q><S><Q><T><L><Q><T><D><Y><I><T><Y><V><D><E><L><G><S><F><I><G><A><K><P><N><I><P><W><L><F><L><T><D><P><R><L><A><L><E><V><Y><F><G><P><C><S><P><Y><Q><F><R><L><M><G><P><G><K><W><D><G><A><R><N><A><I><L><T><Q><W><N><R><T><V><K><P><T><R><T><R><V><V><S><E><V><Q><R><P><H><P><F><Y><N><L><L><K><M><L><S><F><P><L><L><L><L><A><V><T><L><T><F><Y> | It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full-length transcripts.<BOP> | O60774 |
Q8IW45 | NNRD_HUMAN | NAD(P)HX dehydratase | Homo | <M><V><T><R><A><G><A><G><T><A><V><A><G><A><V><V><V><A><L><L><S><A><A><L><A><L><Y><G><P><P><L><D><A><V><L><E><R><A><F><S><L><R><K><A><H><S><I><K><D><M><E><N><T><L><Q><L><V><R><N><I><I><P><P><L><S><S><T><K><H><K><G><Q><D><G><R><I><G><V><V><G><G><C><Q><E><Y><T><G><A><P><Y><F><A><A><I><S><A><L><K><V><G><A><D><L><S><H><V><F><C><A><S><A><A><A><P><V><I><K><A><Y><S><P><E><L><I><V><H><P><V><L><D><S><P><N><A><V><H><E><V><E><K><W><L><P><R><L><H><A><L><V><V><G><P><G><L><G><R><D><D><A><L><L><R><N><V><Q><G><I><L><E><V><S><K><A><R><D><I><P><V><V><I><D><A><D><G><L><W><L><V><A><Q><Q><P><A><L><I><H><G><Y><R><K><A><V><L><T><P><N><H><V><E><F><S><R><L><Y><D><A><V><L><R><G><P><M><D><S><D><D><S><H><G><S><V><L><R><L><S><Q><A><L><G><N><V><T><V><V><Q><K><G><E><R><D><I><L><S><N><G><Q><Q><V><L><V><C><S><Q><E><G><S><S><R><R><C><G><G><Q><G><D><L><L><S><G><S><L><G><V><L><V><H><W><A><L><L><A><G><P><Q><K><T><N><G><S><S><P><L><L><V><A><A><F><G><A><C><S><L><T><R><Q><C><N><H><Q><A><F><Q><K><H><G><R><S><T><T><T><S><D><M><I><A><E><V><G><A><A><F><S><K><L><F><E><T> | Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.<BOP> | Q8IW45 |
A6NKX4 | S22AV_HUMAN | Putative solute carrier family 22 member 31 | Homo | <M><E><Q><E><A><R><V><L><R><A><A><G><G><F><G><R><A><R><R><L><L><A><S><A><S><W><V><P><C><I><V><L><G><L><V><L><S><S><E><E><L><L><T><A><Q><P><A><P><H><C><R><P><D><P><T><L><L><P><P><A><L><R><A><L><R><G><P><A><L><L><D><A><A><I><P><R><L><G><P><T><R><A><P><A><E><A><L><G><V><L><S><P><S><Y><L><A><P><L><T><R><A><P><R><P><S><S><W><A><S><C><S><G><A><A><A><G><P><T><W><N><L><V><C><G><D><G><W><K><V><P><L><E><Q><V><S><H><L><L><G><W><L><L><G><C><V><I><L><G><A><G><C><D><R><F><G><R><R><A><V><F><V><A><S><L><V><L><T><T><G><L><G><A><S><E><A><L><A><A><S><F><P><T><L><L><V><L><R><L><L><H><G><G><T><L><A><G><A><L><L><A><L><Y><L><A><R><L><E><L><C><D><P><P><H><R><L><A><F><S><M><G><A><G><L><F><S><V><V><G><T><L><L><L><P><G><L><A><A><L><V><Q><D><W><R><L><L><Q><G><L><G><A><L><M><S><G><L><L><L><L><F><W><G><F><P><A><L><F><P><E><S><P><C><W><L><L><A><T><G><Q><V><A><R><A><R><K><I><L><W><R><F><A><E><A><S><G><V><G><P><G><D><S><S><L><E><E><N><S><L><A><T><E><L><T><M><L><S><A><R><S><P><Q><P><R><Y><H><S><P><L><G><L><L><R><T><R><V><T><W><R><N><G><L><I><L><G><F><S><S><L><V><G><G><G><I><R><A><S><F><R><R><S><L><A><P><Q><V><P><T><F><Y><L><P><Y><F><L><E><A><G><L><E><A><A><A><L><V><F><L><L><L><T><A><D><C><C><G><R><R><P><V><L><L><L><G><T><M><V><T><G><L><A><S><L><L><L><L><A><G><A><Q><Y><L><P><G><W><T><V><L><F><L><S><V><L><G><L><L><A><S><R><A><V><S><A><L><S><S><L><F><A><A><E><V><F><P><T><V><I><R><G><A><G><L><G><L><V><L><G><A><G><F><L><G><Q><A><A><G><P><L><D><T><L><H><G><R><Q><G><F><F><L><Q><Q><V><V><F><A><S><L><A><V><L><A><L><L><C><V><L><L><L><P><E><S><R><S><R><G><L><P><Q><S><L><Q><D><A><D><R><L><R><R><S><P><L><L><R><G><R><P><R><Q><D><H><L><P><L><L><P><P><S><N><S><Y><W><A><G><H><T><P><E><Q><H> | Organic anion transporter that mediates the uptake of ions.<BOP> | A6NKX4 |
Q13425 | SNTB2_HUMAN | Syntrophin-like | Homo | <M><R><V><A><A><A><T><A><A><A><G><A><G><P><A><M><A><V><W><T><R><A><T><K><A><G><L><V><E><L><L><L><R><E><R><W><V><R><V><V><A><E><L><S><G><E><S><L><S><L><T><G><D><A><A><A><A><E><L><E><P><A><L><G><P><A><A><A><A><F><N><G><L><P><N><G><G><G><A><G><D><S><L><P><G><S><P><S><R><G><L><G><P><P><S><P><P><A><P><P><R><G><P><A><G><E><A><G><A><S><P><P><V><R><R><V><R><V><V><K><Q><E><A><G><G><L><G><I><S><I><K><G><G><R><E><N><R><M><P><I><L><I><S><K><I><F><P><G><L><A><A><D><Q><S><R><A><L><R><L><G><D><A><I><L><S><V><N><G><T><D><L><R><Q><A><T><H><D><Q><A><V><Q><A><L><K><R><A><G><K><E><V><L><L><E><V><K><F><I><R><E><V><T><P><Y><I><K><K><P><S><L><V><S><D><L><P><W><E><G><A><A><P><Q><S><P><S><F><S><G><S><E><D><S><G><S><P><K><H><Q><N><S><T><K><D><R><K><I><I><P><L><K><M><C><F><A><A><R><N><L><S><M><P><D><L><E><N><R><L><I><E><L><H><S><P><D><S><R><N><T><L><I><L><R><C><K><D><T><A><T><A><H><S><W><F><V><A><I><H><T><N><I><M><A><L><L><P><Q><V><L><A><E><L><N><A><M><L><G><A><T><S><T><A><G><G><S><K><E><V><K><H><I><A><W><L><A><E><Q><A><K><L><D><G><G><R><Q><Q><W><R><P><V><L><M><A><V><T><E><K><D><L><L><L><Y><D><C><M><P><W><T><R><D><A><W><A><S><P><C><H><S><Y><P><L><V><A><T><R><L><V><H><S><G><S><G><C><R><S><P><S><L><G><S><D><L><T><F><A><T><R><T><G><S><R><Q><G><I><E><M><H><L><F><R><V><E><T><H><R><D><L><S><S><W><T><R><I><L><V><Q><G><C><H><A><A><A><E><L><I><K><E><V><S><L><G><C><M><L><N><G><Q><E><V><R><L><T><I><H><Y><E><N><G><F><T><I><S><R><E><N><G><G><S><S><S><I><L><Y><R><Y><P><F><E><R><L><K><M><S><A><D><D><G><I><R><N><L><Y><L><D><F><G><G><P><E><G><E><L><T><M><D><L><H><S><C><P><K><P><I><V><F><V><L><H><T><F><L><S><A><K><V><T><R><M><G><L><L><V> | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.<BOP> | Q13425 |
Q8N4P2 | TT30B_HUMAN | Tetratricopeptide repeat protein 30B | Homo | <M><A><G><L><S><G><A><Q><I><P><D><G><E><F><T><A><V><V><Y><R><L><I><R><N><A><R><Y><A><E><A><V><Q><L><L><G><G><E><L><Q><R><S><P><R><S><R><A><G><L><S><L><L><G><Y><C><Y><Y><R><L><Q><E><F><A><L><A><A><E><C><Y><E><Q><L><G><Q><L><H><P><E><L><E><Q><Y><R><L><Y><Q><A><Q><A><L><Y><K><A><C><L><Y><A><E><A><T><R><V><A><F><L><L><L><D><N><P><A><Y><H><S><R><V><L><R><L><Q><A><A><I><K><Y><S><E><G><D><L><P><G><S><R><S><L><V><E><Q><L><P><S><R><E><G><G><E><E><S><G><G><E><N><E><T><D><G><Q><I><N><L><G><C><L><L><Y><K><E><G><Q><Y><E><A><A><C><S><K><F><F><A><A><L><Q><A><S><G><Y><Q><P><D><L><S><Y><N><L><A><L><A><Y><Y><S><S><R><Q><Y><A><S><A><L><K><H><I><A><E><I><I><E><R><G><I><R><Q><H><P><E><L><G><V><G><M><T><T><E><G><I><D><V><R><S><V><G><N><T><L><V><L><H><Q><T><A><L><V><E><A><F><N><L><K><A><A><I><E><Y><Q><L><R><N><Y><E><A><A><Q><E><A><L><T><D><M><P><P><R><A><E><E><E><L><D><P><V><T><L><H><N><Q><A><L><M><N><M><D><A><R><P><T><E><G><F><E><K><L><Q><F><L><L><Q><Q><N><P><F><P><P><E><T><F><G><N><L><L><L><L><Y><C><K><Y><E><Y><F><D><L><A><A><D><V><L><A><E><N><A><H><L><I><Y><K><F><L><T><P><Y><L><Y><D><F><L><D><A><V><I><T><C><Q><T><A><P><E><E><A><F><I><K><L><D><G><L><A><G><M><L><T><E><V><L><R><K><L><T><I><Q><V><Q><E><A><R><H><N><R><D><D><E><A><I><K><K><A><V><N><E><Y><D><E><T><M><E><K><Y><I><P><V><L><M><A><Q><A><K><I><Y><W><N><L><E><N><Y><P><M><V><E><K><I><F><R><K><S><V><E><F><C><N><D><H><D><V><W><K><L><N><V><A><H><V><L><F><M><Q><E><N><K><Y><K><E><A><I><G><F><Y><E><P><I><V><K><K><H><Y><D><N><I><L><N><V><S><A><I><V><L><A><N><L><C><V><S><Y><I><M><T><S><Q><N><E><E><A><E><E><L><M><R><K><I><E><K><E><E><E><Q><L><S><Y><D><D><P><D><K><K><M><Y><H><L><C><I><V><N><L><V><I><G><T><L><Y><C><A><K><G><N><Y><D><F><G><I><S><R><V><I><K><S><L><E><P><Y><N><K><K><L><G><T><D><T><W><Y><Y><A><K><R><C><F><L><S><L><L><E><N><M><S><K><H><T><I><M><L><R><D><S><V><I><Q><E><C><V><Q><F><L><E><H><C><E><L><H><G><R><N><I><P><A><V><I><E><Q><P><L><E><E><E><R><M><H><V><G><K><N><T><V><T><Y><E><S><R><Q><L><K><A><L><I><Y><E><I><I><G><W><N><I> | Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.<BOP> | Q8N4P2 |
Q8N187 | CARTF_HUMAN | Testis development protein NYD-SP24 | Homo | <M><E><Q><S><N><D><S><L><R><V><N><H><N><D><G><E><E><S><K><T><S><A><Q><V><F><E><H><L><I><C><M><D><S><R><D><S><S><F><G><Q><N><D><S><P><T><V><L><P><I><T><T><R><E><A><N><N><S><L><I><S><Q><N><I><P><G><P><L><T><Q><T><Q><T><L><S><A><E><Q><F><H><L><V><D><Q><N><G><Q><A><I><Q><Y><E><L><Q><S><L><G><E><S><N><A><Q><M><M><I><V><A><S><P><T><E><N><G><Q><V><L><R><V><I><P><P><T><Q><T><G><M><A><Q><V><I><I><P><Q><G><Q><L><V><D><V><N><S><P><R><D><V><P><E><E><K><P><S><N><R><N><L><P><T><V><R><V><D><T><L><A><D><N><T><S><N><Y><I><L><H><P><Q><T><S><F><P><L><P><K><K><S><V><T><G><M><L><E><E><P><L><L><G><P><L><Q><P><L><S><S><N><T><P><I><W><A><C><R><L><R><S><C><E><K><I><G><D><S><Y><R><G><Y><C><V><S><E><T><E><L><E><S><V><L><T><F><H><K><Q><Q><T><Q><S><V><W><G><T><R><Q><S><P><S><P><A><K><P><A><T><R><L><M><W><K><S><Q><Y><V><P><Y><D><G><I><P><F><V><N><A><G><S><R><A><V><V><M><E><C><Q><Y><G><P><R><R><K><G><F><Q><L><K><K><V><S><E><Q><E><S><R><S><C><Q><L><Y><K><A><T><C><P><A><R><I><Y><I><K><K><V><Q><K><F><P><E><Y><R><V><P><T><D><P><K><I><D><K><K><I><I><R><M><E><Q><E><K><A><F><N><M><L><K><K><N><L><V><D><A><G><G><V><L><R><W><Y><V><Q><L><P><T><Q><Q><A><H><Q><Y><H><E><L><E><T><P><C><L><T><L><S><P><S><P><F><P><V><S><S><L><E><E><E><E><T><A><V><R><D><E><N><C><A><L><P><S><R><L><H><P><Q><V><A><H><K><I><Q><E><L><V><S><Q><G><I><E><Q><V><Y><A><V><R><K><Q><L><R><K><F><V><E><R><E><L><F><K><P><D><E><V><P><E><R><H><N><L><S><F><F><P><T><V><N><D><I><K><N><H><I><H><E><V><Q><K><S><L><R><N><G><D><T><V><Y><N><S><E><I><I><P><A><T><L><Q><W><T><T><D><S><G><N><I><L><K><E><T><M><T><V><T><F><A><E><G><N><S><P><G><E><S><I><T><T><K><V><E><T><N><Q><T><R><G><S><L><S><P><E><P><T><H><L><L><S><S><L><S><S><F><Q><P><K><I><F><T><Q><L><Q><G><L><Q><L><Q><P><R><Y><T><S><P><D><E><S><P><A><V><V><S><V><N><N><Q><P><S><S><S><P><S><G><L><L><D><T><I><G><S><A><V><M><N><N><N><S><L><L><L><G><Q><S><H><S><L><Q><R><D><T><C><L><T><Q><N><N><S><T><A><S><T><M><G><N><L><P><E><P><D><Q><N><L><V><A><M><D><E><L><V><E><V><G><D><V><E><D><T><G><N><L><E><G><T><V><H><R><I><L><L><G><D><V><Q><T><I><P><I><Q><I><I><D><N><H><S><A><L><I><E><E><N><P><E><S><T><I><S><V><S><Q><V><K><Q><E><P><K><E><P><A><L><S><M><E><A><K><K><T><V><D><Y><K><K><L><S><A><T> | Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.<BOP> | Q8N187 |
P23677 | IP3KA_HUMAN | Inositol 1,4,5-trisphosphate 3-kinase A | Homo | <M><T><L><P><G><G><P><T><G><M><A><R><P><G><G><A><R><P><C><S><P><G><L><E><R><A><P><R><R><S><V><G><E><L><R><L><L><F><E><A><R><C><A><A><V><A><A><A><A><A><A><G><E><P><R><A><R><G><A><K><R><R><G><G><Q><V><P><N><G><L><P><R><A><P><P><A><P><V><I><P><Q><L><T><V><T><A><E><E><P><D><V><P><P><T><S><P><G><P><P><E><R><E><R><D><C><L><P><A><A><G><S><S><H><L><Q><Q><P><R><R><L><S><T><S><S><V><S><S><T><G><S><S><S><L><L><E><D><S><E><D><D><L><L><S><D><S><E><S><R><S><R><G><N><V><Q><L><E><A><G><E><D><V><G><Q><K><N><H><W><Q><K><I><R><T><M><V><N><L><P><V><I><S><P><F><K><K><R><Y><A><W><V><Q><L><A><G><H><T><G><S><F><K><A><A><G><T><S><G><L><I><L><K><R><C><S><E><P><E><R><Y><C><L><A><R><L><M><A><D><A><L><R><G><C><V><P><A><F><H><G><V><V><E><R><D><G><E><S><Y><L><Q><L><Q><D><L><L><D><G><F><D><G><P><C><V><L><D><C><K><M><G><V><R><T><Y><L><E><E><E><L><T><K><A><R><E><R><P><K><L><R><K><D><M><Y><K><K><M><L><A><V><D><P><E><A><P><T><E><E><E><H><A><Q><R><A><V><T><K><P><R><Y><M><Q><W><R><E><G><I><S><S><S><T><T><L><G><F><R><I><E><G><I><K><K><A><D><G><S><C><S><T><D><F><K><T><T><R><S><R><E><Q><V><L><R><V><F><E><E><F><V><Q><G><D><E><E><V><L><R><R><Y><L><N><R><L><Q><Q><I><R><D><T><L><E><V><S><E><F><F><R><R><H><E><V><I><G><S><S><L><L><F><V><H><D><H><C><H><R><A><G><V><W><L><I><D><F><G><K><T><T><P><L><P><D><G><Q><I><L><D><H><R><R><P><W><E><E><G><N><R><E><D><G><Y><L><L><G><L><D><N><L><I><G><I><L><A><S><L><A><E><R> | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.<BOP> | P23677 |
C9JN71 | ZN878_HUMAN | Zinc finger protein 878 | Homo | <M><D><S><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><A><L><L><D><P><S><Q><K><N><L><Y><R><E><V><M><Q><E><T><L><R><N><L><T><S><I><G><K><K><W><N><N><Q><Y><I><E><D><E><H><Q><N><P><R><R><N><L><R><R><L><I><G><E><R><L><S><E><S><K><E><S><H><Q><H><G><E><V><L><T><Q><V><P><D><D><T><L><K><K><K><T><P><G><V><Q><S><Y><E><S><S><V><C><G><E><I><G><I><G><L><S><S><L><N><R><H><L><R><A><F><S><Y><S><S><S><L><A><I><H><G><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><F><P><S><S><V><R><R><H><E><R><I><H><S><A><K><K><P><Y><E><C><K><Q><C><G><K><A><F><S><F><P><S><S><V><R><R><H><E><R><I><H><S><A><K><K><P><Y><E><C><K><Q><C><G><K><A><L><S><Y><L><V><S><F><Q><T><H><M><R><M><H><T><G><E><R><P><H><K><C><N><I><C><G><K><A><F><F><S><P><S><S><L><K><R><H><E><K><S><H><T><G><E><K><R><Y><K><C><K><Q><C><D><K><A><F><N><C><P><S><S><F><Q><Y><H><E><R><T><H><S><G><E><K><P><Y><E><C><T><Q><C><R><K><A><F><R><S><V><K><Y><L><R><V><H><E><R><K><H><T><G><E><K><P><Y><E><C><K><L><C><G><K><G><F><I><S><S><T><S><F><R><Y><H><E><K><T><H><T><G><E><K><P><Y><E><C><K><K><C><V><K><A><F><S><F><V><K><D><L><R><I><H><E><R><T><H><T><G><E><K><P><F><E><C><K><Q><C><G><K><T><F><T><S><S><N><S><F><H><Y><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><V><L><Q><K><H><I><R><T><H><T><G><E><K><P><Y><G><C><K><Q><C><G><K><V><F><R><V><A><S><Q><L><K><M><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><I><S><S><N><S><I><R><Y><H><K><R><T><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><I><S><S><N><S><F><L><Y><H><E><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><S><A><S><I><L><Q><K><H><V><R><T><H><A><G> | May be involved in transcriptional regulation.<BOP> | C9JN71 |
Q969G2 | LHX4_HUMAN | LIM/homeobox protein Lhx4 | Homo | <M><M><Q><S><A><T><V><P><A><E><G><A><V><K><G><L><P><E><M><L><G><V><P><M><Q><Q><I><P><Q><C><A><G><C><N><Q><H><I><L><D><K><F><I><L><K><V><L><D><R><H><W><H><S><S><C><L><K><C><A><D><C><Q><M><Q><L><A><D><R><C><F><S><R><A><G><S><V><Y><C><K><E><D><F><F><K><R><F><G><T><K><C><T><A><C><Q><Q><G><I><P><P><T><Q><V><V><R><K><A><Q><D><F><V><Y><H><L><H><C><F><A><C><I><I><C><N><R><Q><L><A><T><G><D><E><F><Y><L><M><E><D><G><R><L><V><C><K><E><D><Y><E><T><A><K><Q><N><D><D><S><E><A><G><A><K><R><P><R><T><T><I><T><A><K><Q><L><E><T><L><K><N><A><Y><K><N><S><P><K><P><A><R><H><V><R><E><Q><L><S><S><E><T><G><L><D><M><R><V><V><Q><V><W><F><Q><N><R><R><A><K><E><K><R><L><K><K><D><A><G><R><H><R><W><G><Q><F><Y><K><S><V><K><R><S><R><G><S><S><K><Q><E><K><E><S><S><A><E><D><C><G><V><S><D><S><E><L><S><F><R><E><D><Q><I><L><S><E><L><G><H><T><N><R><I><Y><G><N><V><G><D><V><T><G><G><Q><L><M><N><G><S><F><S><M><D><G><T><G><Q><S><Y><Q><D><L><R><D><G><S><P><Y><G><I><P><Q><S><P><S><S><I><S><S><L><P><S><H><A><P><L><L><N><G><L><D><Y><T><V><D><S><N><L><G><I><I><A><H><A><G><Q><G><V><S><Q><T><L><R><A><M><A><G><G><P><T><S><D><I><S><T><G><S><S><V><G><Y><P><D><F><P><T><S><P><G><S><W><L><D><E><M><D><H><P><P><F> | May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA .<BOP> | Q969G2 |
A0A087WXM9 | MEIKN_HUMAN | Meiosis-specific kinetochore protein | Homo | <M><W><P><L><R><V><Y><T><R><K><K><R><E><G><Q><R><L><N><L><T><P><T><P><D><L><G><S><P><A><K><A><E><A><P><P><G><S><K><R><K><G><K><V><H><G><L><S><K><I><A><E><K><A><E><R><S><R><Q><G><G><S><G><S><G><P><F><S><P><R><L><G><V><T><G><E><K><S><L><Q><E><N><R><S><S><E><D><T><Q><D><E><K><I><A><S><L><R><E><S><V><T><D><D><L><Q><V><D><S><S><S><S><N><S><E><L><V><S><G><L><S><L><H><H><G><M><A><S><S><L><L><S><Y><S><V><T><D><S><Y><A><E><Y><K><S><F><E><E><S><F><P><S><P><E><L><F><R><K><S><D><Y><L><D><W><E><C><P><N><L><E><E><H><M><Q><W><K><N><S><T><L><L><D><T><S><K><A><V><A><I><E><K><A><P><Q><F><S><N><V><S><A><I><F><S><T><S><S><E><D><Y><Q><K><C><H><R><K><T><V><M><T><V><A><D><Q><N><V><S><P><K><A><K><C><A><S><N><S><E><S><D><N><A><A><C><E><I><L><L><A><E><K><T><C><P><S><T><P><E><K><T><K><K><K><K><T><N><S><S><T><P><G><K><K><N><R><G><L><L><T><S><T><P><S><S><E><T><A><G><F><V><I><D><L><S><S><V><Q><K><A><S><F><E><E><L><F><P><N><V><S><N><Y><V><N><S><N><E><I><V><P><V><S><S><L><Q><E><N><S><S><N><E><F><P><A><N><A><S><E><I><C><C><I><I><R><T><S><P><G><T><R><Q><V><K><N><K><G><V><I><V><K><K><K><K><Y><S><L><P><K><D><T><P><Q><D><I><I><I><K><M><A> | Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.<BOP> | A0A087WXM9 |
O14770 | MEIS2_HUMAN | Meis1-related protein 1 | Homo | <M><A><Q><R><Y><D><E><L><P><H><Y><G><G><M><D><G><V><G><V><P><A><S><M><Y><G><D><P><H><A><P><R><P><I><P><P><V><H><H><L><N><H><G><P><P><L><H><A><T><Q><H><Y><G><A><H><A><P><H><P><N><V><M><P><A><S><M><G><S><A><V><N><D><A><L><K><R><D><K><D><A><I><Y><G><H><P><L><F><P><L><L><A><L><V><F><E><K><C><E><L><A><T><C><T><P><R><E><P><G><V><A><G><G><D><V><C><S><S><D><S><F><N><E><D><I><A><V><F><A><K><Q><V><R><A><E><K><P><L><F><S><S><N><P><E><L><D><N><L><M><I><Q><A><I><Q><V><L><R><F><H><L><L><E><L><E><K><V><H><E><L><C><D><N><F><C><H><R><Y><I><S><C><L><K><G><K><M><P><I><D><L><V><I><D><E><R><D><G><S><S><K><S><D><H><E><E><L><S><G><S><S><T><N><L><A><D><H><N><P><S><S><W><R><D><H><D><D><A><T><S><T><H><S><A><G><T><P><G><P><S><S><G><G><H><A><S><Q><S><G><D><N><S><S><E><Q><G><D><G><L><D><N><S><V><A><S><P><G><T><G><D><D><D><D><P><D><K><D><K><K><R><Q><K><K><R><G><I><F><P><K><V><A><T><N><I><M><R><A><W><L><F><Q><H><L><T><H><P><Y><P><S><E><E><Q><K><K><Q><L><A><Q><D><T><G><L><T><I><L><Q><V><N><N><W><F><I><N><A><R><R><R><I><V><Q><P><M><I><D><Q><S><N><R><A><G><F><L><L><D><P><S><V><S><Q><G><A><A><Y><S><P><E><G><Q><P><M><G><S><F><V><L><D><G><Q><Q><H><M><G><I><R><P><A><G><L><Q><S><M><P><G><D><Y><V><S><Q><G><G><P><M><G><M><S><M><A><Q><P><S><Y><T><P><P><Q><M><T><P><H><P><T><Q><L><R><H><G><P><P><M><H><S><Y><L><P><S><H><P><H><H><P><A><M><M><M><H><G><G><P><P><T><H><P><G><M><T><M><S><A><Q><S><P><T><M><L><N><S><V><D><P><N><V><G><G><Q><V><M><D><I><H><A><Q> | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the | O14770 |
P0DOX4 | IGE_HUMAN | Immunoglobulin epsilon heavy chain ND | Homo | <Q><V><Q><L><V><Q><S><G><A><E><V><R><K><P><G><A><S><V><R><V><S><C><K><A><S><G><Y><T><F><I><D><S><Y><V><G><W><I><R><Q><A><P><G><H><G><L><E><W><I><H><W><I><N><P><N><S><G><G><T><N><Y><A><P><R><F><Q><G><R><V><T><M><T><R><D><A><S><F><S><T><A><Y><M><D><L><R><S><L><R><S><D><D><S><A><V><F><Y><C><A><K><S><D><P><F><W><S><D><Y><N><F><D><Y><S><S><S><E><E><G><T><E><V><T><Y><T><V><S><G><A><W><T><L><P><S><V><F><P><L><T><R><C><C><K><N><I><P><S><N><A><T><S><V><T><L><G><C><L><A><T><G><Y><F><P><E><P><V><M><V><T><W><D><T><G><S><L><N><G><T><T><L><P><A><T><T><L><T><L><S><G><H><Y><A><T><I><S><L><L><T><V><S><G><A><W><A><K><Q><M><F><T><C><R><V><A><H><T><P><S><S><T><V><D><N><K><T><F><S><V><C><S><R><D><F><T><P><P><T><V><K><I><L><Q><S><S><C><D><G><L><G><H><F><P><P><T><I><Q><L><C><L><V><S><G><Y><T><P><G><T><I><N><I><T><W><L><E><D><G><Q><V><M><D><V><D><L><S><T><A><S><T><E><S><Q><G><E><L><A><S><T><E><S><Q><L><T><L><S><Q><K><H><W><L><S><D><R><T><Y><T><C><Q><V><T><Y><Q><G><H><T><F><Q><D><S><T><K><K><C><A><D><S><N><P><R><G><V><S><A><Y><L><S><R><P><S><P><F><D><L><F><I><R><K><S><P><T><I><T><C><L><V><V><D><L><A><P><S><K><G><T><V><N><L><T><W><S><R><A><S><G><K><P><V><N><H><S><T><R><K><E><E><K><Q><R><N><G><T><L><T><V><T><S><T><L><P><V><G><T><R><D><W><I><E><G><E><T><Y><Q><C><R><V><T><H><P><H><L><P><R><A><L><M><R><S><T><T><K><T><S><G><P><R><A><A><P><E><V><Y><A><F><A><T><P><E><W><P><G><S><R><D><K><R><T><L><A><C><L><I><Q><N><F><M><P><E><D><I><S><V><Q><W><L><H><N><E><V><Q><L><P><D><A><R><H><S><T><T><Q><P><R><K><T><K><G><S><G><F><F><V><F><S><R><L><E><V><T><R><A><E><W><Q><E><K><D><E><F><I><C><R><A><V><H><E><A><A><S><P><S><Q><T><V><Q><R><A><V><S><V><N><P><G><K> | Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P0DOX4 |
P49585 | PCY1A_HUMAN | Phosphorylcholine transferase A | Homo | <M><D><A><Q><C><S><A><K><V><N><A><R><K><R><R><K><E><A><P><G><P><N><G><A><T><E><E><D><G><V><P><S><K><V><Q><R><C><A><V><G><L><R><Q><P><A><P><F><S><D><E><I><E><V><D><F><S><K><P><Y><V><R><V><T><M><E><E><A><S><R><G><T><P><C><E><R><P><V><R><V><Y><A><D><G><I><F><D><L><F><H><S><G><H><A><R><A><L><M><Q><A><K><N><L><F><P><N><T><Y><L><I><V><G><V><C><S><D><E><L><T><H><N><F><K><G><F><T><V><M><N><E><N><E><R><Y><D><A><V><Q><H><C><R><Y><V><D><E><V><V><R><N><A><P><W><T><L><T><P><E><F><L><A><E><H><R><I><D><F><V><A><H><D><D><I><P><Y><S><S><A><G><S><D><D><V><Y><K><H><I><K><E><A><G><M><F><A><P><T><Q><R><T><E><G><I><S><T><S><D><I><I><T><R><I><V><R><D><Y><D><V><Y><A><R><R><N><L><Q><R><G><Y><T><A><K><E><L><N><V><S><F><I><N><E><K><K><Y><H><L><Q><E><R><V><D><K><V><K><K><K><V><K><D><V><E><E><K><S><K><E><F><V><Q><K><V><E><E><K><S><I><D><L><I><Q><K><W><E><E><K><S><R><E><F><I><G><S><F><L><E><M><F><G><P><E><G><A><L><K><H><M><L><K><E><G><K><G><R><M><L><Q><A><I><S><P><K><Q><S><P><S><S><S><P><T><R><E><R><S><P><S><P><S><F><R><W><P><F><S><G><K><T><S><P><P><C><S><P><A><N><L><S><R><H><K><A><A><A><Y><D><I><S><E><D><E><E><D> | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.<BOP> | P49585 |
Q9UHK0 | NUFP1_HUMAN | Nuclear FMRP-interacting protein 1 | Homo | <M><A><E><P><T><S><D><F><E><T><P><I><G><W><H><A><S><P><E><L><T><P><T><L><G><P><L><S><D><T><A><P><P><R><D><S><W><M><F><W><A><M><L><P><P><P><P><P><P><L><T><S><S><L><P><A><A><G><S><K><P><S><S><E><S><Q><P><P><M><E><A><Q><S><L><P><G><A><P><P><P><F><D><A><Q><I><L><P><G><A><Q><P><P><F><D><A><Q><S><P><L><D><S><Q><P><Q><P><S><G><Q><P><W><N><F><H><A><S><T><S><W><Y><W><R><Q><S><S><D><R><F><P><R><H><Q><K><S><F><N><P><A><V><K><N><S><Y><Y><P><R><K><Y><D><A><K><F><T><D><F><S><L><P><P><S><R><K><Q><K><K><K><K><R><K><E><P><V><F><H><F><F><C><D><T><C><D><R><G><F><K><N><Q><E><K><Y><D><K><H><M><S><E><H><T><K><C><P><E><L><D><C><S><F><T><A><H><E><K><I><V><Q><F><H><W><R><N><M><H><A><P><G><M><K><K><I><K><L><D><T><P><E><E><I><A><R><W><R><E><E><R><R><K><N><Y><P><T><L><A><N><I><E><R><K><K><K><L><K><L><E><K><E><K><R><G><A><V><L><T><T><T><Q><Y><G><K><M><K><G><M><S><R><H><S><Q><M><A><K><I><R><S><P><G><K><N><H><K><W><K><N><D><N><S><R><Q><R><A><V><T><G><S><G><S><H><L><C><D><L><K><L><E><G><P><P><E><A><N><A><D><P><L><G><V><L><I><N><S><D><S><E><S><D><K><E><E><K><P><Q><H><S><V><I><P><K><E><V><T><P><A><L><C><S><L><M><S><S><Y><G><S><L><S><G><S><E><S><E><P><E><E><T><P><I><K><T><E><A><D><V><L><A><E><N><Q><V><L><D><S><S><A><P><K><S><P><S><Q><D><V><K><A><T><V><R><N><F><S><E><A><K><S><E><N><R><K><K><S><F><E><K><T><N><P><K><R><K><K><D><Y><H><N><Y><Q><T><L><F><E><P><R><T><H><H><P><Y><L><L><E><M><L><L><A><P><D><I><R><H><E><R><N><V><I><L><Q><C><V><R><Y><I><I><K><K><D><F><F><G><L><D><T><N><S><A><K><S><K><D><V> | Binds RNA.<BOP> | Q9UHK0 |
Q9NP95 | FGF20_HUMAN | Fibroblast growth factor 20 | Homo | <M><A><P><L><A><E><V><G><G><F><L><G><G><L><E><G><L><G><Q><Q><V><G><S><H><F><L><L><P><P><A><G><E><R><P><P><L><L><G><E><R><R><S><A><A><E><R><S><A><R><G><G><P><G><A><A><Q><L><A><H><L><H><G><I><L><R><R><R><Q><L><Y><C><R><T><G><F><H><L><Q><I><L><P><D><G><S><V><Q><G><T><R><Q><D><H><S><L><F><G><I><L><E><F><I><S><V><A><V><G><L><V><S><I><R><G><V><D><S><G><L><Y><L><G><M><N><D><K><G><E><L><Y><G><S><E><K><L><T><S><E><C><I><F><R><E><Q><F><E><E><N><W><Y><N><T><Y><S><S><N><I><Y><K><H><G><D><T><G><R><R><Y><F><V><A><L><N><K><D><G><T><P><R><D><G><A><R><S><K><R><H><Q><K><F><T><H><F><L><P><R><P><V><D><P><E><R><V><P><E><L><Y><K><D><L><L><M><Y><T> | Neurotrophic factor that regulates central nervous development and function.<BOP> | Q9NP95 |
Q9UHQ9 | NB5R1_HUMAN | NAD(P)H:quinone oxidoreductase type 3 polypeptide A2 | Homo | <M><G><I><Q><T><S><P><V><L><L><A><S><L><G><V><G><L><V><T><L><L><G><L><A><V><G><S><Y><L><V><R><R><S><R><R><P><Q><V><T><L><L><D><P><N><E><K><Y><L><L><R><L><L><D><K><T><T><V><S><H><N><T><K><R><F><R><F><A><L><P><T><A><H><H><T><L><G><L><P><V><G><K><H><I><Y><L><S><T><R><I><D><G><S><L><V><I><R><P><Y><T><P><V><T><S><D><E><D><Q><G><Y><V><D><L><V><I><K><V><Y><L><K><G><V><H><P><K><F><P><E><G><G><K><M><S><Q><Y><L><D><S><L><K><V><G><D><V><V><E><F><R><G><P><S><G><L><L><T><Y><T><G><K><G><H><F><N><I><Q><P><N><K><K><S><P><P><E><P><R><V><A><K><K><L><G><M><I><A><G><G><T><G><I><T><P><M><L><Q><L><I><R><A><I><L><K><V><P><E><D><P><T><Q><C><F><L><L><F><A><N><Q><T><E><K><D><I><I><L><R><E><D><L><E><E><L><Q><A><R><Y><P><N><R><F><K><L><W><F><T><L><D><H><P><P><K><D><W><A><Y><S><K><G><F><V><T><A><D><M><I><R><E><H><L><P><A><P><G><D><D><V><L><V><L><L><C><G><P><P><P><M><V><Q><L><A><C><H><P><N><L><D><K><L><G><Y><S><Q><K><M><R><F><T><Y> | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.<BOP> | Q9UHQ9 |
P17987 | TCPA_HUMAN | CCT-alpha | Homo | <M><E><G><P><L><S><V><F><G><D><R><S><T><G><E><T><I><R><S><Q><N><V><M><A><A><A><S><I><A><N><I><V><K><S><S><L><G><P><V><G><L><D><K><M><L><V><D><D><I><G><D><V><T><I><T><N><D><G><A><T><I><L><K><L><L><E><V><E><H><P><A><A><K><V><L><C><E><L><A><D><L><Q><D><K><E><V><G><D><G><T><T><S><V><V><I><I><A><A><E><L><L><K><N><A><D><E><L><V><K><Q><K><I><H><P><T><S><V><I><S><G><Y><R><L><A><C><K><E><A><V><R><Y><I><N><E><N><L><I><V><N><T><D><E><L><G><R><D><C><L><I><N><A><A><K><T><S><M><S><S><K><I><I><G><I><N><G><D><F><F><A><N><M><V><V><D><A><V><L><A><I><K><Y><T><D><I><R><G><Q><P><R><Y><P><V><N><S><V><N><I><L><K><A><H><G><R><S><Q><M><E><S><M><L><I><S><G><Y><A><L><N><C><V><V><G><S><Q><G><M><P><K><R><I><V><N><A><K><I><A><C><L><D><F><S><L><Q><K><T><K><M><K><L><G><V><Q><V><V><I><T><D><P><E><K><L><D><Q><I><R><Q><R><E><S><D><I><T><K><E><R><I><Q><K><I><L><A><T><G><A><N><V><I><L><T><T><G><G><I><D><D><M><C><L><K><Y><F><V><E><A><G><A><M><A><V><R><R><V><L><K><R><D><L><K><R><I><A><K><A><S><G><A><T><I><L><S><T><L><A><N><L><E><G><E><E><T><F><E><A><A><M><L><G><Q><A><E><E><V><V><Q><E><R><I><C><D><D><E><L><I><L><I><K><N><T><K><A><R><T><S><A><S><I><I><L><R><G><A><N><D><F><M><C><D><E><M><E><R><S><L><H><D><A><L><C><V><V><K><R><V><L><E><S><K><S><V><V><P><G><G><G><A><V><E><A><A><L><S><I><Y><L><E><N><Y><A><T><S><M><G><S><R><E><Q><L><A><I><A><E><F><A><R><S><L><L><V><I><P><N><T><L><A><V><N><A><A><Q><D><S><T><D><L><V><A><K><L><R><A><F><H><N><E><A><Q><V><N><P><E><R><K><N><L><K><W><I><G><L><D><L><S><N><G><K><P><R><D><N><K><Q><A><G><V><F><E><P><T><I><V><K><V><K><S><L><K><F><A><T><E><A><A><I><T><I><L><R><I><D><D><L><I><K><L><H><P><E><S><K><D><D><K><H><G><S><Y><E><D><A><V><H><S><G><A><L><N><D> | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable).<BOP> | P17987 |
P60370 | KR105_HUMAN | Keratin-associated protein 18.5 | Homo | <M><A><A><C><T><M><S><V><C><S><S><A><C><S><D><S><W><R><V><D><D><C><P><E><S><C><C><E><P><P><C><G><T><A><P><C><L><T><L><V><C><T><P><V><S><C><V><S><S><P><C><C><Q><A><A><C><E><P><S><P><C><Q><S><G><C><T><S><S><C><T><P><S><C><C><Q><P><A><C><C><A><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><P><V><C><C><L><P><T><C><S><K><D><S><S><S><C><C><Q><Q><S><S><C><Q><P><T><C><C><A><S><S><S><C><Q><Q><S><C><C><V><P><V><C><C><K><P><V><C><C><V><P><T><C><S><E><D><S><S><S><C><C><Q><H><S><S><C><Q><P><T><C><C><T><S><S><P><C><Q><Q><S><C><Y><V><P><V><C><C><K><P><V><C><C><K><P><I><C><C><V><P><V><C><S><G><A><S><T><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><I><C><R><P><A><C><C><L><P><I><S><S><C><C><A><P><A><S><S><Y><Q><A><S><C><C><R><P><A><S><C><V><S><L><L><C><R><P><A><C><S><P><L><A><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | P60370 |
Q16585 | SGCB_HUMAN | A3b | Homo | <M><A><A><A><A><A><A><A><A><E><Q><Q><S><S><N><G><P><V><K><K><S><M><R><E><K><A><V><E><R><R><S><V><N><K><E><H><N><S><N><F><K><A><G><Y><I><P><I><D><E><D><R><L><H><K><T><G><L><R><G><R><K><G><N><L><A><I><C><V><I><I><L><L><F><I><L><A><V><I><N><L><I><I><T><L><V><I><W><A><V><I><R><I><G><P><N><G><C><D><S><M><E><F><H><E><S><G><L><L><R><F><K><Q><V><S><D><M><G><V><I><H><P><L><Y><K><S><T><V><G><G><R><R><N><E><N><L><V><I><T><G><N><N><Q><P><I><V><F><Q><Q><G><T><T><K><L><S><V><E><N><N><K><T><S><I><T><S><D><I><G><M><Q><F><F><D><P><R><T><Q><N><I><L><F><S><T><D><Y><E><T><H><E><F><H><L><P><S><G><V><K><S><L><N><V><Q><K><A><S><T><E><R><I><T><S><N><A><T><S><D><L><N><I><K><V><D><G><R><A><I><V><R><G><N><E><G><V><F><I><M><G><K><T><I><E><F><H><M><G><G><N><M><E><L><K><A><E><N><S><I><I><L><N><G><S><V><M><V><S><T><T><R><L><P><S><S><S><S><G><D><Q><L><G><S><G><D><W><V><R><Y><K><L><C><M><C><A><D><G><T><L><F><K><V><Q><V><T><S><Q><N><M><G><C><Q><I><S><D><N><P><C><G><N><T><H> | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.<BOP> | Q16585 |
O60669 | MOT2_HUMAN | Solute carrier family 16 member 7 | Homo | <M><P><P><M><P><S><A><P><P><V><H><P><P><P><D><G><G><W><G><W><I><V><V><G><A><A><F><I><S><I><G><F><S><Y><A><F><P><K><A><V><T><V><F><F><K><E><I><Q><Q><I><F><H><T><T><Y><S><E><I><A><W><I><S><S><I><M><L><A><V><M><Y><A><G><G><P><V><S><S><V><L><V><N><K><Y><G><S><R><P><V><V><I><A><G><G><L><L><C><C><L><G><M><V><L><A><S><F><S><S><S><V><V><Q><L><Y><L><T><M><G><F><I><T><G><L><G><L><A><F><N><L><Q><P><A><L><T><I><I><G><K><Y><F><Y><R><K><R><P><M><A><N><G><L><A><M><A><G><S><P><V><F><L><S><S><L><A><P><F><N><Q><Y><L><F><N><T><F><G><W><K><G><S><F><L><I><L><G><S><L><L><L><N><A><C><V><A><G><S><L><M><R><P><L><G><P><N><Q><T><T><S><K><S><K><N><K><T><G><K><T><E><D><D><S><S><P><K><K><I><K><T><K><K><S><T><W><E><K><V><N><K><Y><L><D><F><S><L><F><K><H><R><G><F><L><I><Y><L><S><G><N><V><I><M><F><L><G><F><F><A><P><I><I><F><L><A><P><Y><A><K><D><Q><G><I><D><E><Y><S><A><A><F><L><L><S><V><M><A><F><V><D><M><F><A><R><P><S><V><G><L><I><A><N><S><K><Y><I><R><P><R><I><Q><Y><F><F><S><F><A><I><M><F><N><G><V><C><H><L><L><C><P><L><A><Q><D><Y><T><S><L><V><L><Y><A><V><F><F><G><L><G><F><G><S><V><S><S><V><L><F><E><T><L><M><D><L><V><G><A><P><R><F><S><S><A><V><G><L><V><T><I><V><E><C><G><P><V><L><L><G><P><P><L><A><G><K><L><V><D><L><T><G><E><Y><K><Y><M><Y><M><S><C><G><A><I><V><V><A><A><S><V><W><L><L><I><G><N><A><I><N><Y><R><L><L><A><K><E><R><K><E><E><N><A><R><Q><K><T><R><E><S><E><P><L><S><K><S><K><H><S><E><D><V><N><V><K><V><S><N><A><Q><S><V><T><S><E><R><E><T><N><I> | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate . Dimerization is functionally required and both subunits work cooperatively in transporting substrate .<BOP> | O60669 |
Q05952 | STP2_HUMAN | Nuclear transition protein 2 | Homo | <M><D><T><Q><T><H><S><L><P><I><T><H><T><Q><L><H><S><N><S><Q><P><Q><S><R><T><C><T><R><H><C><Q><T><F><S><Q><S><C><R><Q><S><H><R><G><S><R><S><Q><S><S><S><Q><S><P><A><S><H><R><N><P><T><G><A><H><S><S><S><G><H><Q><S><Q><S><P><N><T><S><P><P><P><K><R><H><K><K><T><M><N><S><H><H><S><P><M><R><P><T><I><L><H><C><R><C><P><K><N><R><K><N><L><E><G><K><L><K><K><K><K><M><A><K><R><I><Q><Q><V><Y><K><T><K><T><R><S><S><G><W><K><S><N> | Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.<BOP> | Q05952 |
Q9H3H1 | MOD5_HUMAN | tRNA isopentenyltransferase 1 | Homo | <M><A><S><V><A><A><A><R><A><V><P><V><G><S><G><L><R><G><L><Q><R><T><L><P><L><V><V><I><L><G><A><T><G><T><G><K><S><T><L><A><L><Q><L><G><Q><R><L><G><G><E><I><V><S><A><D><S><M><Q><V><Y><E><G><L><D><I><I><T><N><K><V><S><A><Q><E><Q><R><I><C><R><H><H><M><I><S><F><V><D><P><L><V><T><N><Y><T><V><V><D><F><R><N><R><A><T><A><L><I><E><D><I><F><A><R><D><K><I><P><I><V><V><G><G><T><N><Y><Y><I><E><S><L><L><W><K><V><L><V><N><T><K><P><Q><E><M><G><T><E><K><V><I><D><R><K><V><E><L><E><K><E><D><G><L><V><L><H><K><R><L><S><Q><V><D><P><E><M><A><A><K><L><H><P><H><D><K><R><K><V><A><R><S><L><Q><V><F><E><E><T><G><I><S><H><S><E><F><L><H><R><Q><H><T><E><E><G><G><G><P><L><G><G><P><L><K><F><S><N><P><C><I><L><W><L><H><A><D><Q><A><V><L><D><E><R><L><D><K><R><V><D><D><M><L><A><A><G><L><L><E><E><L><R><D><F><H><R><R><Y><N><Q><K><N><V><S><E><N><S><Q><D><Y><Q><H><G><I><F><Q><S><I><G><F><K><E><F><H><E><Y><L><I><T><E><G><K><C><T><L><E><T><S><N><Q><L><L><K><K><G><I><E><A><L><K><Q><V><T><K><R><Y><A><R><K><Q><N><R><W><V><K><N><R><F><L><S><R><P><G><P><I><V><P><P><V><Y><G><L><E><V><S><D><V><S><K><W><E><E><S><V><L><E><P><A><L><E><I><V><Q><S><F><I><Q><G><H><K><P><T><A><T><P><I><K><M><P><Y><N><E><A><E><N><K><R><S><Y><H><L><C><D><L><C><D><R><I><I><I><G><D><R><E><W><A><A><H><I><K><S><K><S><H><L><N><Q><L><K><K><R><R><R><L><D><S><D><A><V><N><T><I><E><S><Q><S><V><S><P><D><H><N><K><E><P><K><E><K><G><S><P><G><Q><N><D><Q><E><L><K><C><S><V> | Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) . Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) . TRIT1 is therefore required for selenoprotein expression .<BOP> | Q9H3H1 |
Q8TAC9 | SCAM5_HUMAN | Secretory carrier-associated membrane protein 5 | Homo | <M><A><E><K><V><N><N><F><P><P><L><P><K><F><I><P><L><K><P><C><F><Y><Q><D><F><E><A><D><I><P><P><Q><H><V><S><M><T><K><R><L><Y><Y><L><W><M><L><N><S><V><T><L><A><V><N><L><V><G><C><L><A><W><L><I><G><G><G><G><A><T><N><F><G><L><A><F><L><W><L><I><L><F><T><P><C><S><Y><V><C><W><F><R><P><I><Y><K><A><F><K><T><D><S><S><F><S><F><M><A><F><F><F><T><F><M><A><Q><L><V><I><S><I><I><Q><A><V><G><I><P><G><W><G><V><C><G><W><I><A><T><I><S><F><F><G><T><N><I><G><S><A><V><V><M><L><I><P><T><V><M><F><T><V><M><A><V><F><S><F><I><A><L><S><M><V><H><K><F><Y><R><G><S><G><G><S><F><S><K><A><Q><E><E><W><T><T><G><A><W><K><N><P><H><V><Q><Q><A><A><Q><N><A><A><M><G><A><A><Q><G><A><M><N><Q><P><Q><T><Q><Y><S><A><T><P><N><Y><T><Y><S><N><E><M> | Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway.<BOP> | Q8TAC9 |
Q8NHQ9 | DDX55_HUMAN | DEAD box protein 55 | Homo | <M><E><H><V><T><E><G><S><W><E><S><L><P><V><P><L><H><P><Q><V><L><G><A><L><R><E><L><G><F><P><Y><M><T><P><V><Q><S><A><T><I><P><L><F><M><R><N><K><D><V><A><A><E><A><V><T><G><S><G><K><T><L><A><F><V><I><P><I><L><E><I><L><L><R><R><E><E><K><L><K><K><S><Q><V><G><A><I><I><I><T><P><T><R><E><L><A><I><Q><I><D><E><V><L><S><H><F><T><K><H><F><P><E><F><S><Q><I><L><W><I><G><G><R><N><P><G><E><D><V><E><R><F><K><Q><Q><G><G><N><I><I><V><A><T><P><G><R><L><E><D><M><F><R><R><K><A><E><G><L><D><L><A><S><C><V><R><S><L><D><V><L><V><L><D><E><A><D><R><L><L><D><M><G><F><E><A><S><I><N><T><I><L><E><F><L><P><K><Q><R><R><T><G><L><F><S><A><T><Q><T><Q><E><V><E><N><L><V><R><A><G><L><R><N><P><V><R><V><S><V><K><E><K><G><V><A><A><S><S><A><Q><K><T><P><S><R><L><E><N><Y><Y><M><V><C><K><A><D><E><K><F><N><Q><L><V><H><F><L><R><N><H><K><Q><E><K><H><L><V><F><F><S><T><C><A><C><V><E><Y><Y><G><K><A><L><E><V><L><V><K><G><V><K><I><M><C><I><H><G><K><M><K><Y><K><R><N><K><I><F><M><E><F><R><K><L><Q><S><G><I><L><V><C><T><D><V><M><A><R><G><I><D><I><P><E><V><N><W><V><L><Q><Y><D><P><P><S><N><A><S><A><F><V><H><R><C><G><R><T><A><R><I><G><H><G><G><S><A><L><V><F><L><L><P><M><E><E><S><Y><I><N><F><L><A><I><N><Q><K><C><P><L><Q><E><M><K><P><Q><R><N><T><A><D><L><L><P><K><L><K><S><M><A><L><A><D><R><A><V><F><E><K><G><M><K><A><F><V><S><Y><V><Q><A><Y><A><K><H><E><C><N><L><I><F><R><L><K><D><L><D><F><A><S><L><A><R><G><F><A><L><L><R><M><P><K><M><P><E><L><R><G><K><Q><F><P><D><F><V><P><V><D><V><N><T><D><T><I><P><F><K><D><K><I><R><E><K><Q><R><Q><K><L><L><E><Q><Q><R><R><E><K><T><E><N><E><G><R><R><K><F><I><K><N><K><A><W><S><K><Q><K><A><K><K><E><K><K><K><K><M><N><E><K><R><K><R><E><E><G><S><D><I><E><D><E><D><M><E><E><L><L><N><D><T><R><L><L><K><K><L><K><K><G><K><I><T><E><E><E><F><E><K><G><L><L><T><T><G><K><R><T><I><K><T><V><D><L><G><I><S><D><L><E><D><D><C> | Probable ATP-binding RNA helicase.<BOP> | Q8NHQ9 |
Q9H1B4 | NXF5_HUMAN | TAP-like protein 1 | Homo | <M><R><R><N><T><Q><D><E><N><M><R><K><W><F><K><V><T><I><P><Y><G><I><K><Y><D><K><A><W><L><M><N><S><I><Q><S><N><C><S><V><P><F><T><P><V><D><F><H><Y><I><R><N><R><A><C><F><F><V><Q><V><A><S><A><A><S><A><L><K><D><V><S><Y><K><I><Y><D><D><E><N><Q><K><I><C><I><F><V><S><H><F><T><A><P><Y><S><V><K><N><K><L><K><P><G><Q><M><E><M><L><K><L><T><M><N><K><R><Y><N><V><S><Q><Q><A><L><D><L><Q><N><L><R><F><D><P><D><L><M><G><R><D><I><D><I><I><L><N><R><R><N><C><M><A><A><T><L><K><I><T><E><R><N><F><P><E><L><L><S><L><N><L><C><N><N><K><L><Y><Q><L><D><G><L><S><D><I><T><E><K><A><P><K><V><K><T><L><N><L><S><K><N><K><L><E><S><A><W><E><L><G><K><V><K><G><L><K><L><E><E><L><W><L><E><G><N><P><L><C><S><T><F><S><D><Q><S><A><Y><V><S><A><I><R><D><C><F><P><K><L><L><R><L><D><G><R><E><L><S><A><P><V><I><V><D><I><D><S><S><E><T><M><K><P><C><K><E><N><F><T><G><S><E><T><L><K><H><L><V><L><Q><F><L><Q><Q><S><N><L><C><K><Y><F><K><D><S><R><N><I><K><I><L><K><D><P><Y><L><Q><R><K><L><L><K><H><T><K><C><P><R><N><V><D><S><L><S><A><L><P><E><T><Q><H><D><F><T><S><I><L><V><D><M><W><Y><Q><T><V><N><T><C><F><L><P><R><A><G><P><E><S><Q><R><W><W><C><L><L><S><L><K><W><K><D><G><L><R><V><L><I><L><P><S><C><G><P><S><S><L><P><L><A><A><I><P><V><C><A><S> | Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.<BOP> | Q9H1B4 |
Q9H1Y0 | ATG5_HUMAN | Apoptosis-specific protein | Homo | <M><T><D><D><K><D><V><L><R><D><V><W><F><G><R><I><P><T><C><F><T><L><Y><Q><D><E><I><T><E><R><E><A><E><P><Y><Y><L><L><L><P><R><V><S><Y><L><T><L><V><T><D><K><V><K><K><H><F><Q><K><V><M><R><Q><E><D><I><S><E><I><W><F><E><Y><E><G><T><P><L><K><W><H><Y><P><I><G><L><L><F><D><L><L><A><S><S><S><A><L><P><W><N><I><T><V><H><F><K><S><F><P><E><K><D><L><L><H><C><P><S><K><D><A><I><E><A><H><F><M><S><C><M><K><E><A><D><A><L><K><H><K><S><Q><V><I><N><E><M><Q><K><K><D><H><K><Q><L><W><M><G><L><Q><N><D><R><F><D><Q><F><W><A><I><N><R><K><L><M><E><Y><P><A><E><E><N><G><F><R><Y><I><P><F><R><I><Y><Q><T><T><T><E><R><P><F><I><Q><K><L><F><R><P><V><A><A><D><G><Q><L><H><T><L><G><D><L><L><K><E><V><C><P><S><A><I><D><P><E><D><G><E><K><K><N><Q><V><M><I><H><G><I><E><P><M><L><E><T><P><L><Q><W><L><S><E><H><L><S><Y><P><D><N><F><L><H><I><S><I><I><P><Q><P><T><D> | (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection . Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for initiation of HCV replication, but not required once infection is established .<BOP> | Q9H1Y0 |
Q8N9N2 | ASCC1_HUMAN | Trip4 complex subunit p50 | Homo | <M><E><V><L><R><P><Q><L><I><R><I><D><G><R><N><Y><R><K><N><P><V><Q><E><Q><T><Y><Q><H><E><E><D><E><E><D><F><Y><Q><G><S><M><E><C><A><D><E><P><C><D><A><Y><E><V><E><Q><T><P><Q><G><F><R><S><T><L><R><A><P><S><L><L><Y><N><L><I><H><L><N><T><S><N><D><C><G><F><Q><K><I><T><L><D><C><Q><N><I><Y><T><W><K><S><R><H><I><V><G><K><R><G><D><T><R><K><K><I><E><M><E><T><K><T><S><I><S><I><P><K><P><G><Q><D><G><E><I><V><I><T><G><Q><H><R><N><G><V><I><S><A><R><T><R><I><D><V><L><L><D><T><F><R><R><K><Q><P><F><T><H><F><L><A><F><F><L><N><E><V><E><V><Q><E><G><F><L><R><F><Q><E><E><V><L><A><K><C><S><M><D><H><G><V><D><S><S><I><F><Q><N><P><K><K><L><H><L><T><I><G><M><L><V><L><L><S><E><E><E><I><Q><Q><T><C><E><M><L><Q><Q><C><K><E><E><F><I><N><D><I><S><G><G><K><P><L><E><V><E><M><A><G><I><E><Y><M><N><D><D><P><G><M><V><D><V><L><Y><A><K><V><H><M><K><D><G><S><N><R><L><Q><E><L><V><D><R><V><L><E><R><F><Q><A><S><G><L><I><V><K><E><W><N><S><V><K><L><H><A><T><V><M><N><T><L><F><R><K><D><P><N><A><E><G><R><Y><N><L><Y><T><A><E><G><K><Y><I><F><K><E><R><E><S><F><D><G><R><N><I><L><K><S><F><A><L><L><P><R><L><E><Y><N><D><A><I><S><A><H><C><N><L><C><L><P><G><S><S><D><S><P><A><S><A><S><Q><V><A><G><I><T><G><V><S><D><A><Y><S><Q><S><L><P><G><K><S> | Plays a role in DNA damage repair as component of the ASCC complex . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation . In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.<BOP> | Q8N9N2 |
Q14137 | BOP1_HUMAN | Block of proliferation 1 protein | Homo | <M><A><G><S><R><G><A><G><R><T><A><A><P><S><V><R><P><E><K><R><R><S><E><P><E><L><E><P><E><P><E><P><E><P><P><L><L><C><T><S><P><L><S><H><S><T><G><S><D><S><G><V><S><D><S><E><E><S><V><F><S><G><L><E><D><S><G><S><D><S><S><E><D><D><D><E><G><D><E><E><G><E><D><G><A><L><D><D><E><G><H><S><G><I><K><K><T><T><E><E><Q><V><Q><A><S><T><P><C><P><R><T><E><M><A><S><A><R><I><G><D><E><Y><A><E><D><S><S><D><E><E><D><I><R><N><T><V><G><N><V><P><L><E><W><Y><D><D><F><P><H><V><G><Y><D><L><D><G><R><R><I><Y><K><P><L><R><T><R><D><E><L><D><Q><F><L><D><K><M><D><D><P><D><Y><W><R><T><V><Q><D><P><M><T><G><R><D><L><R><L><T><D><E><Q><V><A><L><V><R><R><L><Q><S><G><Q><F><G><D><V><G><F><N><P><Y><E><P><A><V><D><F><F><S><G><D><V><M><I><H><P><V><T><N><R><P><A><D><K><R><S><F><I><P><S><L><V><E><K><E><K><V><S><R><M><V><H><A><I><K><M><G><W><I><Q><P><R><R><P><R><D><P><T><P><S><F><Y><D><L><W><A><Q><E><D><P><N><A><V><L><G><R><H><K><M><H><V><P><A><P><K><L><A><L><P><G><H><A><E><S><Y><N><P><P><P><E><Y><L><L><S><E><E><E><R><L><A><W><E><Q><Q><E><P><G><E><R><K><L><S><F><L><P><R><K><F><P><S><L><R><A><V><P><A><Y><G><R><F><I><Q><E><R><F><E><R><C><L><D><L><Y><L><C><P><R><Q><R><K><M><R><V><N><V><D><P><E><D><L><I><P><K><L><P><R><P><R><D><L><Q><P><F><P><T><C><Q><A><L><V><Y><R><G><H><S><D><L><V><R><C><L><S><V><S><P><G><G><Q><W><L><V><S><G><S><D><D><G><S><L><R><L><W><E><V><A><T><A><R><C><V><R><T><V><P><V><G><G><V><V><K><S><V><A><W><N><P><S><P><A><V><C><L><V><A><A><A><V><E><D><S><V><L><L><L><N><P><A><L><G><D><R><L><V><A><G><S><T><D><Q><L><L><S><A><F><V><P><P><E><E><P><P><L><Q><P><A><R><W><L><E><A><S><E><E><E><R><Q><V><G><L><R><L><R><I><C><H><G><K><P><V><T><Q><V><T><W><H><G><R><G><D><Y><L><A><V><V><L><A><T><Q><G><H><T><Q><V><L><I><H><Q><L><S><R><R><R><S><Q><S><P><F><R><R><S><H><G><Q><V><Q><R><V><A><F><H><P><A><R><P><F><L><L><V><A><S><Q><R><S><V><R><L><Y><H><L><L><R><Q><E><L><T><K><K><L><M><P><N><C><K><W><V><S><S><L><A><V><H><P><A><G><D><N><V><I><C><G><S><Y><D><S><K><L><V><W><F><D><L><D><L><S><T><K><P><Y><R><M><L><R><H><H><K><K><A><L><R><A><V><A><F><H><P><R><Y><P><L><F><A><S><G><S><D><D><G><S><V><I><V><C><H><G><M><V><Y><N><D><L><L><Q><N><P><L><L><V><P><V><K><V><L><K><G><H><V><L><T><R><D><L><G><V><L><D><V><I><F><H><P><T><Q><P><W><V><F><S><S><G><A><D><G><T><V><R><L><F><T> | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.<BOP> | Q14137 |
P52954 | LBX1_HUMAN | Ladybird homeobox protein homolog 1 | Homo | <M><T><S><K><E><D><G><K><A><A><P><G><E><E><R><R><R><S><P><L><D><H><L><P><P><P><A><N><S><N><K><P><L><T><P><F><S><I><E><D><I><L><N><K><P><S><V><R><R><S><Y><S><L><C><G><A><A><H><L><L><A><A><A><D><K><H><A><Q><G><G><L><P><L><A><G><R><A><L><L><S><Q><T><S><P><L><C><A><L><E><E><L><A><S><K><T><F><K><G><L><E><V><S><V><L><Q><A><A><E><G><R><D><G><M><T><I><F><G><Q><R><Q><T><P><K><K><R><R><K><S><R><T><A><F><T><N><H><Q><I><Y><E><L><E><K><R><F><L><Y><Q><K><Y><L><S><P><A><D><R><D><Q><I><A><Q><Q><L><G><L><T><N><A><Q><V><I><T><W><F><Q><N><R><R><A><K><L><K><R><D><L><E><E><M><K><A><D><V><E><S><A><K><K><L><G><P><S><G><Q><M><D><I><V><A><L><A><E><L><E><Q><N><S><E><A><T><A><G><G><G><G><G><C><G><R><A><K><S><R><P><G><S><P><V><L><P><P><G><A><P><K><A><P><G><A><G><A><L><Q><L><S><P><A><S><P><L><T><D><Q><P><A><S><S><Q><D><C><S><E><D><E><E><D><E><E><I><D><V><D><D> | Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.<BOP> | P52954 |
A0A075B6Y9 | TJA42_HUMAN | T cell receptor alpha joining 42 | Homo | <Y><G><G><S><Q><G><N><L><I><F><G><K><G><T><K><L><S><V><K><P> | J region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearr | A0A075B6Y9 |
P55899 | FCGRN_HUMAN | Neonatal Fc receptor | Homo | <M><G><V><P><R><P><Q><P><W><A><L><G><L><L><L><F><L><L><P><G><S><L><G><A><E><S><H><L><S><L><L><Y><H><L><T><A><V><S><S><P><A><P><G><T><P><A><F><W><V><S><G><W><L><G><P><Q><Q><Y><L><S><Y><N><S><L><R><G><E><A><E><P><C><G><A><W><V><W><E><N><Q><V><S><W><Y><W><E><K><E><T><T><D><L><R><I><K><E><K><L><F><L><E><A><F><K><A><L><G><G><K><G><P><Y><T><L><Q><G><L><L><G><C><E><L><G><P><D><N><T><S><V><P><T><A><K><F><A><L><N><G><E><E><F><M><N><F><D><L><K><Q><G><T><W><G><G><D><W><P><E><A><L><A><I><S><Q><R><W><Q><Q><Q><D><K><A><A><N><K><E><L><T><F><L><L><F><S><C><P><H><R><L><R><E><H><L><E><R><G><R><G><N><L><E><W><K><E><P><P><S><M><R><L><K><A><R><P><S><S><P><G><F><S><V><L><T><C><S><A><F><S><F><Y><P><P><E><L><Q><L><R><F><L><R><N><G><L><A><A><G><T><G><Q><G><D><F><G><P><N><S><D><G><S><F><H><A><S><S><S><L><T><V><K><S><G><D><E><H><H><Y><C><C><I><V><Q><H><A><G><L><A><Q><P><L><R><V><E><L><E><S><P><A><K><S><S><V><L><V><V><G><I><V><I><G><V><L><L><L><T><A><A><A><V><G><G><A><L><L><W><R><R><M><R><S><G><L><P><A><P><W><I><S><L><R><G><D><D><T><G><V><L><L><P><T><P><G><E><A><Q><D><A><D><L><K><D><V><N><V><I><P><A><T><A> | (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.<BOP> | P55899 |
Q9NRG4 | SMYD2_HUMAN | SET and MYND domain-containing protein 2 | Homo | <M><R><A><E><G><L><G><G><L><E><R><F><C><S><P><G><K><G><R><G><L><R><A><L><Q><P><F><Q><V><G><D><L><L><F><S><C><P><A><Y><A><Y><V><L><T><V><N><E><R><G><N><H><C><E><Y><C><F><T><R><K><E><G><L><S><K><C><G><R><C><K><Q><A><F><Y><C><N><V><E><C><Q><K><E><D><W><P><M><H><K><L><E><C><S><P><M><V><V><F><G><E><N><W><N><P><S><E><T><V><R><L><T><A><R><I><L><A><K><Q><K><I><H><P><E><R><T><P><S><E><K><L><L><A><V><K><E><F><E><S><H><L><D><K><L><D><N><E><K><K><D><L><I><Q><S><D><I><A><A><L><H><H><F><Y><S><K><H><L><G><F><P><D><N><D><S><L><V><V><L><F><A><Q><V><N><C><N><G><F><T><I><E><D><E><E><L><S><H><L><G><S><A><I><F><P><D><V><A><L><M><N><H><S><C><C><P><N><V><I><V><T><Y><K><G><T><L><A><E><V><R><A><V><Q><E><I><K><P><G><E><E><V><F><T><S><Y><I><D><L><L><Y><P><T><E><D><R><N><D><R><L><R><D><S><Y><F><F><T><C><E><C><Q><E><C><T><T><K><D><K><D><K><A><K><V><E><I><R><K><L><S><D><P><P><K><A><E><A><I><R><D><M><V><R><Y><A><R><N><V><I><E><E><F><R><R><A><K><H><Y><K><S><P><S><E><L><L><E><I><C><E><L><S><Q><E><K><M><S><S><V><F><E><D><S><N><V><Y><M><L><H><M><M><Y><Q><A><M><G><V><C><L><Y><M><Q><D><W><E><G><A><L><Q><Y><G><Q><K><I><I><K><P><Y><S><K><H><Y><P><L><Y><S><L><N><V><A><S><M><W><L><K><L><G><R><L><Y><M><G><L><E><H><K><A><A><G><E><K><A><L><K><K><A><I><A><I><M><E><V><A><H><G><K><D><H><P><Y><I><S><E><I><K><Q><E><I><E><S><H> | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.<BOP> | Q9NRG4 |
Q8N5S1 | S2541_HUMAN | Solute carrier family 25 member 41 | Homo | <M><G><A><Q><P><G><E><P><Q><N><T><C><S><R><I><Q><T><L><F><R><R><V><K><T><L><L><I><K><A><P><P><P><P><Q><P><P><P><P><P><P><S><W><N><P><G><C><T><H><V><Y><G><Y><A><F><G><H><M><H><D><N><N><L><E><H><L><P><S><Q><Q><V><L><D><T><G><E><Q><L><M><V><P><V><E><V><L><E><V><D><N><K><E><A><L><W><K><F><L><L><S><G><A><M><A><G><A><V><S><R><T><G><T><A><P><L><D><R><A><K><V><Y><M><Q><V><Y><S><S><K><T><N><F><T><N><L><L><G><G><L><Q><S><M><V><Q><E><G><G><F><R><S><L><W><R><G><N><G><I><N><V><L><K><I><A><P><E><Y><A><I><K><F><S><V><F><E><Q><C><K><N><Y><F><C><G><I><Q><G><S><P><P><F><Q><E><R><L><L><A><G><S><L><A><V><A><I><S><Q><T><L><I><N><P><M><E><V><L><K><T><R><L><T><L><R><R><T><G><Q><Y><K><G><L><L><D><C><A><R><Q><I><L><Q><R><E><G><T><R><A><L><Y><R><G><Y><L><P><N><M><L><G><I><I><P><Y><A><C><T><D><L><A><V><Y><E><M><L><Q><C><F><W><V><K><S><G><R><D><M><G><D><P><S><G><L><V><S><L><S><S><V><T><L><S><T><T><C><G><Q><M><A><S><Y><P><L><T><L><V><R><T><R><M><Q><A><Q><D><T><V><E><G><S><N><P><T><M><R><G><V><L><Q><R><I><L><A><Q><Q><G><W><L><G><L><Y><R><G><M><T><P><T><L><L><K><V><L><P><A><G><G><I><S><Y><V><V><Y><E><A><M><K><K><T><L><G><I> | Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane.<BOP> | Q8N5S1 |
Q9NWS1 | PARI_HUMAN | PARP1-binding protein | Homo | <M><A><V><F><N><Q><K><S><V><S><D><M><I><K><E><F><R><K><N><W><R><A><L><C><N><S><E><R><T><T><L><C><G><A><D><S><M><L><L><A><L><Q><L><S><M><A><E><N><N><K><Q><H><S><G><E><F><T><V><S><L><S><D><V><L><L><T><W><K><Y><L><L><H><E><K><L><N><L><P><V><E><N><M><D><V><T><D><H><Y><E><D><V><R><K><I><Y><D><D><F><L><K><N><S><N><M><L><D><L><I><D><V><Y><Q><K><C><R><A><L><T><S><N><C><E><N><Y><N><T><V><S><P><S><Q><L><L><D><F><L><S><G><K><Q><Y><A><V><G><D><E><T><D><L><S><I><P><T><S><P><T><S><K><Y><N><R><D><N><E><K><V><Q><L><L><A><R><K><I><I><F><S><Y><L><N><L><L><V><N><S><K><N><D><L><A><V><A><Y><I><L><N><I><P><D><R><G><L><G><R><E><A><F><T><D><L><K><H><A><A><R><E><K><Q><M><S><I><F><L><V><A><T><S><F><I><R><T><I><E><L><G><G><K><G><Y><A><P><P><P><S><D><P><L><R><T><H><V><K><G><L><S><N><F><I><N><F><I><D><K><L><D><E><I><L><G><E><I><P><N><P><S><I><A><G><G><Q><I><L><S><V><I><K><M><Q><L><I><K><G><Q><N><S><R><D><P><F><C><K><A><I><E><E><V><A><Q><D><L><D><L><R><I><K><N><I><I><N><S><Q><E><G><V><V><A><L><S><T><T><D><I><S><P><A><R><P><K><S><H><A><I><N><H><G><T><A><Y><C><G><R><D><T><V><K><A><L><L><V><L><L><D><E><E><A><A><N><A><P><T><K><N><K><A><E><L><L><Y><D><E><E><N><T><I><H><H><H><G><T><S><I><L><T><L><F><R><S><P><T><Q><V><N><N><S><I><K><P><L><R><E><R><I><C><V><S><M><Q><E><K><K><I><K><M><K><Q><T><L><I><R><S><Q><F><A><C><T><Y><K><D><D><Y><M><I><S><K><D><N><W><N><N><V><N><L><A><S><K><P><L><C><V><L><Y><M><E><N><D><L><S><E><G><V><N><P><S><V><G><R><S><T><I><G><T><S><F><G><N><V><H><L><D><R><S><K><N><E><K><V><S><R><K><S><T><S><Q><T><G><N><K><S><S><K><R><K><Q><V><D><L><D><G><E><N><I><L><C><D><N><R><N><E><P><P><Q><H><K><N><A><K><I><P><K><K><S><N><D><S><Q><N><R><L><Y><G><K><L><A><K><V><A><K><S><N><K><C><T><A><K><D><K><L><I><S><G><Q><A><K><L><T><Q><F><F><R><L> | Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.<BOP> | Q9NWS1 |
O95007 | OR6B1_HUMAN | Olfactory receptor OR7-9 | Homo | <M><E><L><E><N><Q><T><R><V><T><K><F><I><L><V><G><F><P><G><S><L><S><M><R><A><A><M><F><L><I><F><L><V><A><Y><I><L><T><V><A><E><N><V><I><I><I><L><L><V><L><Q><N><R><P><L><H><K><P><M><Y><F><F><L><A><N><L><S><F><L><E><T><W><Y><I><S><V><T><V><P><K><L><L><F><S><F><W><S><V><N><N><S><I><S><F><T><L><C><M><I><Q><L><Y><F><F><I><A><L><M><C><T><E><C><V><L><L><A><A><M><A><Y><D><R><Y><V><A><I><C><R><P><L><H><Y><P><T><I><M><S><H><G><L><C><F><R><L><A><L><G><S><W><A><I><G><F><G><I><S><L><A><K><I><Y><F><I><S><C><L><S><F><C><G><P><N><V><I><N><H><F><F><C><D><I><S><P><V><L><N><L><S><C><T><D><M><S><I><T><E><L><V><D><F><I><L><A><L><V><I><F><L><F><P><L><F><I><T><V><L><S><Y><G><C><I><L><A><T><I><L><C><M><P><T><G><K><Q><K><A><F><S><T><C><A><S><H><L><V><V><V><T><I><F><Y><S><A><I><I><F><M><Y><A><R><P><R><V><I><H><A><F><N><M><N><K><I><I><S><I><F><Y><A><I><V><T><P><S><L><N><P><F><I><Y><C><L><R><N><R><E><V><K><E><A><L><K><K><L><A><Y><C><Q><A><S><R><S><D> | Odorant receptor.<BOP> | O95007 |
Q9GZT4 | SRR_HUMAN | L-serine dehydratase | Homo | <M><C><A><Q><Y><C><I><S><F><A><D><V><E><K><A><H><I><N><I><R><D><S><I><H><L><T><P><V><L><T><S><S><I><L><N><Q><L><T><G><R><N><L><F><F><K><C><E><L><F><Q><K><T><G><S><F><K><I><R><G><A><L><N><A><V><R><S><L><V><P><D><A><L><E><R><K><P><K><A><V><V><T><H><S><S><G><N><H><G><Q><A><L><T><Y><A><A><K><L><E><G><I><P><A><Y><I><V><V><P><Q><T><A><P><D><C><K><K><L><A><I><Q><A><Y><G><A><S><I><V><Y><C><E><P><S><D><E><S><R><E><N><V><A><K><R><V><T><E><E><T><E><G><I><M><V><H><P><N><Q><E><P><A><V><I><A><G><Q><G><T><I><A><L><E><V><L><N><Q><V><P><L><V><D><A><L><V><V><P><V><G><G><G><G><M><L><A><G><I><A><I><T><V><K><A><L><K><P><S><V><K><V><Y><A><A><E><P><S><N><A><D><D><C><Y><Q><S><K><L><K><G><K><L><M><P><N><L><Y><P><P><E><T><I><A><D><G><V><K><S><S><I><G><L><N><T><W><P><I><I><R><D><L><V><D><D><I><F><T><V><T><E><D><E><I><K><C><A><T><Q><L><V><W><E><R><M><K><L><L><I><E><P><T><A><G><V><G><V><A><A><V><L><S><Q><H><F><Q><T><V><S><P><E><V><K><N><I><C><I><V><L><S><G><G><N><V><D><L><T><S><S><I><T><W><V><K><Q><A><E><R><P><A><S><Y><Q><S><V><S><V> | Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<BOP> | Q9GZT4 |
P22830 | HEMH_HUMAN | Protoheme ferro-lyase | Homo | <M><R><S><L><G><A><N><M><A><A><A><L><R><A><A><G><V><L><L><R><D><P><L><A><S><S><S><W><R><V><C><Q><P><W><R><W><K><S><G><A><A><A><A><A><V><T><T><E><T><A><Q><H><A><Q><G><A><K><P><Q><V><Q><P><Q><K><R><K><P><K><T><G><I><L><M><L><N><M><G><G><P><E><T><L><G><D><V><H><D><F><L><L><R><L><F><L><D><R><D><L><M><T><L><P><I><Q><N><K><L><A><P><F><I><A><K><R><R><T><P><K><I><Q><E><Q><Y><R><R><I><G><G><G><S><P><I><K><I><W><T><S><K><Q><G><E><G><M><V><K><L><L><D><E><L><S><P><N><T><A><P><H><K><Y><Y><I><G><F><R><Y><V><H><P><L><T><E><E><A><I><E><E><M><E><R><D><G><L><E><R><A><I><A><F><T><Q><Y><P><Q><Y><S><C><S><T><T><G><S><S><L><N><A><I><Y><R><Y><Y><N><Q><V><G><R><K><P><T><M><K><W><S><T><I><D><R><W><P><T><H><H><L><L><I><Q><C><F><A><D><H><I><L><K><E><L><D><H><F><P><L><E><K><R><S><E><V><V><I><L><F><S><A><H><S><L><P><M><S><V><V><N><R><G><D><P><Y><P><Q><E><V><S><A><T><V><Q><K><V><M><E><R><L><E><Y><C><N><P><Y><R><L><V><W><Q><S><K><V><G><P><M><P><W><L><G><P><Q><T><D><E><S><I><K><G><L><C><E><R><G><R><K><N><I><L><L><V><P><I><A><F><T><S><D><H><I><E><T><L><Y><E><L><D><I><E><Y><S><Q><V><L><A><K><E><C><G><V><E><N><I><R><R><A><E><S><L><N><G><N><P><L><F><S><K><A><L><A><D><L><V><H><S><H><I><Q><S><N><E><L><C><S><K><Q><L><T><L><S><C><P><L><C><V><N><P><V><C><R><E><T><K><S><F><F><T><S><Q><Q><L> | Catalyzes the ferrous insertion into protoporphyrin IX.<BOP> | P22830 |
Q6PI73 | LIRA6_HUMAN | Leukocyte Ig-like receptor | Homo | <M><T><P><A><L><T><A><L><L><C><L><G><L><S><L><G><P><R><T><R><V><Q><A><G><P><F><P><K><P><T><L><W><A><E><P><G><S><V><I><S><W><G><S><P><V><T><I><W><C><Q><G><S><L><E><A><Q><E><Y><Q><L><D><K><E><G><S><P><E><P><L><D><R><N><N><P><L><E><P><K><N><K><A><R><F><S><I><P><S><M><T><Q><H><H><A><G><R><Y><R><C><H><Y><Y><S><S><A><G><W><S><E><P><S><D><P><L><E><L><V><M><T><G><F><Y><N><K><P><T><L><S><A><L><P><S><P><V><V><A><S><G><G><N><M><T><L><R><C><G><S><Q><K><G><Y><H><H><F><V><L><M><K><E><G><E><H><Q><L><P><R><T><L><D><S><Q><Q><L><H><S><G><G><F><Q><A><L><F><P><V><G><P><V><T><P><S><H><R><W><R><F><T><C><Y><Y><Y><Y><T><N><T><P><R><V><W><S><H><P><S><D><P><L><E><I><L><P><S><G><V><S><R><K><P><S><L><L><T><L><Q><G><P><V><L><A><P><G><Q><S><L><T><L><Q><C><G><S><D><V><G><Y><D><R><F><V><L><Y><K><E><G><E><R><D><F><L><Q><R><P><G><Q><Q><P><Q><A><G><L><S><Q><A><N><F><T><L><G><P><V><S><P><S><H><G><G><Q><Y><R><C><Y><G><A><H><N><L><S><S><E><W><S><A><P><S><D><P><L><N><I><L><M><A><G><Q><I><Y><D><T><V><S><L><S><A><Q><P><G><P><T><V><A><S><G><E><N><V><T><L><L><C><Q><S><R><G><Y><F><D><T><F><L><L><T><K><E><G><A><A><H><P><P><L><R><L><R><S><M><Y><G><A><H><K><Y><Q><A><E><F><P><M><S><P><V><T><S><A><H><A><G><T><Y><R><C><Y><G><S><Y><S><S><N><P><H><L><L><S><F><P><S><E><P><L><E><L><M><V><S><G><H><S><G><G><S><S><L><P><P><T><G><P><P><S><T><P><A><S><H><A><K><D><Y><T><V><E><N><L><I><R><M><G><M><A><G><L><V><L><V><F><L><G><I><L><L><F><E><A><Q><H><S><Q><R><N><P><Q><D><A><A><G><R> | May act as receptor for class I MHC antigens.<BOP> | Q6PI73 |
O75419 | CDC45_HUMAN | PORC-PI-1 | Homo | <M><F><V><S><D><F><R><K><E><F><Y><E><V><V><Q><S><Q><R><V><L><L><F><V><A><S><D><V><D><A><L><C><A><C><K><I><L><Q><A><L><F><Q><C><D><H><V><Q><Y><T><L><V><P><V><S><G><W><Q><E><L><E><T><A><F><L><E><H><K><E><Q><F><H><Y><F><I><L><I><N><C><G><A><N><V><D><L><L><D><I><L><Q><P><D><E><D><T><I><F><F><V><C><D><T><H><R><P><V><N><V><V><N><V><Y><N><D><T><Q><I><K><L><L><I><K><Q><D><D><D><L><E><V><P><A><Y><E><D><I><F><R><D><E><E><E><D><E><E><H><S><G><N><D><S><D><G><S><E><P><S><E><K><R><T><R><L><E><E><E><I><V><E><Q><T><M><R><R><R><Q><R><R><E><W><E><A><R><R><R><D><I><L><F><D><Y><E><Q><Y><E><Y><H><G><T><S><S><A><M><V><M><F><E><L><A><W><M><L><S><K><D><L><N><D><M><L><W><W><A><I><V><G><L><T><D><Q><W><V><Q><D><K><I><T><Q><M><K><Y><V><T><D><V><G><V><L><Q><R><H><V><S><R><H><N><H><R><N><E><D><E><E><N><T><L><S><V><D><C><T><R><I><S><F><E><Y><D><L><R><L><V><L><Y><Q><H><W><S><L><H><D><S><L><C><N><T><S><Y><T><A><A><R><F><K><L><W><S><V><H><G><Q><K><R><L><Q><E><F><L><A><D><M><G><L><P><L><K><Q><V><K><Q><K><F><Q><A><M><D><I><S><L><K><E><N><L><R><E><M><I><E><E><S><A><N><K><F><G><M><K><D><M><R><V><Q><T><F><S><I><H><F><G><F><K><H><K><F><L><A><S><D><V><V><F><A><T><M><S><L><M><E><S><P><E><K><D><G><S><G><T><D><H><F><I><Q><A><L><D><S><L><S><R><S><N><L><D><K><L><Y><H><G><L><E><L><A><K><K><Q><L><R><A><T><Q><Q><T><I><A><S><C><L><C><T><N><L><V><I><S><Q><G><P><F><L><Y><C><S><L><M><E><G><T><P><D><V><M><L><F><S><R><P><A><S><L><S><L><L><S><K><H><L><L><K><S><F><V><C><S><T><K><N><R><R><C><K><L><L><P><L><V><M><A><A><P><L><S><M><E><H><G><T><V><T><V><V><G><I><P><P><E><T><D><S><S><D><R><K><N><F><F><G><R><A><F><E><K><A><A><E><S><T><S><S><R><M><L><H><N><H><F><D><L><S><V><I><E><L><K><A><E><D><R><S><K><F><L><D><A><L><I><S><L><L><S> | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.<BOP> | O75419 |
A6NJB7 | PRR19_HUMAN | Proline-rich protein 19 | Homo | <M><D><T><Q><G><P><V><S><Q><P><F><Q><Q><P><E><K><P><G><R><V><R><R><R><K><T><R><R><E><R><N><K><A><L><V><G><S><R><R><P><L><A><H><H><D><P><P><V><A><I><R><D><P><P><V><V><P><T><A><S><K><L><V><V><I><T><Q><G><R><L><S><R><E><H><R><G><L><F><N><H><E><V><K><S><L><D><V><A><R><L><L><S><S><G><T><L><V><P><G><S><P><T><L><P><A><K><P><S><P><S><P><G><R><A><Q><E><P><A><P><R><S><R><D><K><E><N><Q><V><P><G><G><S><G><P><G><P><P><S><S><P><E><L><S><G><V><G><Q><L><L><A><E><L><Q><C><Q><L><S><L><P><Q><A><F><P><R><R><N><L><I><Q><D><A><R><D><A><I><V><H><T><L><Q><A><C><H><G><C><V><P><D><L><A><L><V><L><R><G><C><Q><P><P><L><P><G><A><K><P><G><V><S><E><R><K><M><T><P><F><W><I><N><S><P><D><Q><V><P><E><Q><E><R><Q><R><K><Q><Q><G><T><K><E><F><T><F><P><M><P><Y><T><S><S><M><P><T><A><H><R><G><S><L><A><P><P><R><G><P><W><P><P><Y><F><P><S><L><S><S><P><S><G><T><A><W><G><P><P><T><A><F><D><L><L><K><S><I><W><L><V><A><T><P><P><P><P><R><P><W><G><V><G><L><P><Q><P><L><P><Q><P><S><S><P><L><L><P><R><T><S><V><L><D><W><S><P><S><P><P><S><P><L><P><S><L><S><W><V><V><A><Q><S><S><P><E><A><W><S><F><P><P><M><R><L><Y> | Promotes meiotic crossing over formation through its interaction with CNTD1 by participating in the crossover differentiation step of crossover-specific recombination intermediates.<BOP> | A6NJB7 |
O95396 | MOCS3_HUMAN | Sulfurtransferase MOCS3 | Homo | <M><A><S><R><E><E><V><L><A><L><Q><A><E><V><A><Q><R><E><E><E><L><N><S><L><K><Q><K><L><A><S><A><L><L><A><E><Q><E><P><Q><P><E><R><L><V><P><V><S><P><L><P><P><K><A><A><L><S><R><D><E><I><L><R><Y><S><R><Q><L><V><L><P><E><L><G><V><H><G><Q><L><R><L><G><T><A><C><V><L><I><V><G><C><G><G><L><G><C><P><L><A><Q><Y><L><A><A><A><G><V><G><R><L><G><L><V><D><Y><D><V><V><E><M><S><N><L><A><R><Q><V><L><H><G><E><A><L><A><G><Q><A><K><A><F><S><A><A><A><S><L><R><R><L><N><S><A><V><E><C><V><P><Y><T><Q><A><L><T><P><A><T><A><L><D><L><V><R><R><Y><D><V><V><A><D><C><S><D><N><V><P><T><R><Y><L><V><N><D><A><C><V><L><A><G><R><P><L><V><S><A><S><A><L><R><F><E><G><Q><I><T><V><Y><H><Y><D><G><G><P><C><Y><R><C><I><F><P><Q><P><P><P><A><E><T><V><T><N><C><A><D><G><G><V><L><G><V><V><T><G><V><L><G><C><L><Q><A><L><E><V><L><K><I><A><A><G><L><G><P><S><Y><S><G><S><L><L><L><F><D><A><L><R><G><H><F><R><S><I><R><L><R><S><R><R><L><D><C><A><A><C><G><E><R><P><T><V><T><D><L><L><D><Y><E><A><F><C><G><S><S><A><T><D><K><C><R><S><L><Q><L><L><S><P><E><E><R><V><S><V><T><D><Y><K><R><L><L><D><S><G><A><F><H><L><L><L><D><V><R><P><Q><V><E><V><D><I><C><R><L><P><H><A><L><H><I><P><L><K><H><L><E><R><R><D><A><E><S><L><K><L><L><K><E><A><I><W><E><E><K><Q><G><T><Q><E><G><A><A><V><P><I><Y><V><I><C><K><L><G><N><D><S><Q><K><A><V><K><I><L><Q><S><L><S><A><A><Q><E><L><D><P><L><T><V><R><D><V><V><G><G><L><M><A><W><A><A><K><I><D><G><T><F><P><Q><Y> | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.<BOP> | O95396 |
Q8N687 | DB125_HUMAN | Defensin, beta 125 | Homo | <M><N><I><L><M><L><T><F><I><I><C><G><L><L><T><R><V><T><K><G><S><F><E><P><Q><K><C><W><K><N><N><V><G><H><C><R><R><R><C><L><D><T><E><R><Y><I><L><L><C><R><N><K><L><S><C><C><I><S><I><I><S><H><E><Y><T><R><R><P><A><F><P><V><I><H><L><E><D><I><T><L><D><Y><S><D><V><D><S><F><T><G><S><P><V><S><M><L><N><D><L><I><T><F><D><T><T><K><F><G><E><T><M><T><P><E><T><N><T><P><E><T><T><M><P><P><S><E><A><T><T><P><E><T><T><M><P><P><S><E><T><A><T><S><E><T><M><P><P><P><S><Q><T><A><L><T><H><N> | Has antibacterial activity.<BOP> | Q8N687 |
Q92535 | PIGC_HUMAN | Phosphatidylinositol-glycan biosynthesis class C protein | Homo | <M><Y><A><Q><P><V><T><N><T><K><E><V><K><W><Q><K><V><L><Y><E><R><Q><P><F><P><D><N><Y><V><D><R><R><F><L><E><E><L><R><K><N><I><H><A><R><K><Y><Q><Y><W><A><V><V><F><E><S><S><V><V><I><Q><Q><L><C><S><V><C><V><F><V><V><I><W><W><Y><M><D><E><G><L><L><A><P><H><W><L><L><G><T><G><L><A><S><S><L><I><G><Y><V><L><F><D><L><I><D><G><G><E><G><R><K><K><S><G><Q><T><R><W><A><D><L><K><S><A><L><V><F><I><T><F><T><Y><G><F><S><P><V><L><K><T><L><T><E><S><V><S><T><D><T><I><Y><A><M><S><V><F><M><L><L><G><H><L><I><F><F><D><Y><G><A><N><A><A><I><V><S><S><T><L><S><L><N><M><A><I><F><A><S><V><C><L><A><S><R><L><P><R><S><L><H><A><F><I><M><V><T><F><A><I><Q><I><F><A><L><W><P><M><L><Q><K><K><L><K><A><C><T><P><R><S><Y><V><G><V><T><L><L><F><A><F><S><A><V><G><G><L><L><S><I><S><A><V><G><A><V><L><F><A><L><L><L><M><S><I><S><C><L><C><P><F><Y><L><I><R><L><Q><L><F><K><E><N><I><H><G><P><W><D><E><A><E><I><K><E><D><L><S><R><F><L><S> | Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.<BOP> | Q92535 |
P55344 | LMIP_HUMAN | MP20 | Homo | <M><Y><S><F><M><G><G><G><L><F><C><A><W><V><G><T><I><L><L><V><V><A><M><A><T><D><H><W><M><Q><Y><R><L><S><G><S><F><A><H><Q><G><L><W><R><Y><C><L><G><N><K><C><Y><L><Q><T><D><S><I><A><Y><W><N><A><T><R><A><F><M><I><L><S><A><L><C><A><I><S><G><I><I><M><G><I><M><A><F><A><H><Q><P><T><F><S><R><I><S><R><P><F><S><A><G><I><M><F><F><S><S><T><L><F><V><V><L><A><L><A><I><Y><T><G><V><T><V><S><F><L><G><R><R><F><G><D><W><R><F><S><W><S><Y><I><L><G><W><V><A><V><L><M><T><F><F><A><G><I><F><Y><M><C><A><Y><R><V><H><E><C><R><R><L><S><T><P><R> | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.<BOP> | P55344 |
Q13875 | MOBP_HUMAN | Myelin-associated oligodendrocyte basic protein | Homo | <M><S><Q><K><P><A><K><E><G><P><R><L><S><K><N><Q><K><Y><S><E><H><F><S><I><H><C><C><P><P><F><T><F><L><N><S><K><K><E><I><V><D><R><K><Y><S><I><C><K><S><G><C><F><Y><Q><K><K><E><E><D><W><I><C><C><A><C><Q><K><T><R><T><S><R><R><A><K><S><P><Q><R><P><K><Q><Q><P><A><A><P><P><A><V><V><R><A><P><A><K><P><R><S><P><P><R><S><E><R><Q><P><R><S><P><P><R><S><E><R><Q><P><R><S><P><P><R><S><E><R><Q><P><R><S><P><P><R><S><E><R><Q><P><R><P><R><P><E><V><R><P><P><P><A><K><Q><R><P><P><Q><K><S><K><Q><Q><P><R><S><S><P><L><R><G><P><G><A><S><R><G><G><S><P><V><K><A><S><R><F><W> | May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.<BOP> | Q13875 |
O15198 | SMAD9_HUMAN | SMAD family member 9 | Homo | <M><H><S><T><T><P><I><S><S><L><F><S><F><T><S><P><A><V><K><R><L><L><G><W><K><Q><G><D><E><E><E><K><W><A><E><K><A><V><D><S><L><V><K><K><L><K><K><K><K><G><A><M><D><E><L><E><R><A><L><S><C><P><G><Q><P><S><K><C><V><T><I><P><R><S><L><D><G><R><L><Q><V><S><H><R><K><G><L><P><H><V><I><Y><C><R><V><W><R><W><P><D><L><Q><S><H><H><E><L><K><P><L><E><C><C><E><F><P><F><G><S><K><Q><K><E><V><C><I><N><P><Y><H><Y><R><R><V><E><T><P><V><L><P><P><V><L><V><P><R><H><S><E><Y><N><P><Q><L><S><L><L><A><K><F><R><S><A><S><L><H><S><E><P><L><M><P><H><N><A><T><Y><P><D><S><F><Q><Q><P><P><C><S><A><L><P><P><S><P><S><H><A><F><S><Q><S><P><C><T><A><S><Y><P><H><S><P><G><S><P><S><E><P><E><S><P><Y><Q><H><S><V><D><T><P><P><L><P><Y><H><A><T><E><A><S><E><T><Q><S><G><Q><P><V><D><A><T><A><D><R><H><V><V><L><S><I><P><N><G><D><F><R><P><V><C><Y><E><E><P><Q><H><W><C><S><V><A><Y><Y><E><L><N><N><R><V><G><E><T><F><Q><A><S><S><R><S><V><L><I><D><G><F><T><D><P><S><N><N><R><N><R><F><C><L><G><L><L><S><N><V><N><R><N><S><T><I><E><N><T><R><R><H><I><G><K><G><V><H><L><Y><Y><V><G><G><E><V><Y><A><E><C><V><S><D><S><S><I><F><V><Q><S><R><N><C><N><Y><Q><H><G><F><H><P><A><T><V><C><K><I><P><S><G><C><S><L><K><V><F><N><N><Q><L><F><A><Q><L><L><A><Q><S><V><H><H><G><F><E><V><V><Y><E><L><T><K><M><C><T><I><R><M><S><F><V><K><G><W><G><A><E><Y><H><R><Q><D><V><T><S><T><P><C><W><I><E><I><H><L><H><G><P><L><Q><W><L><D><K><V><L><T><Q><M><G><S><P><H><N><P><I><S><S><V><S> | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).<BOP> | O15198 |
P05549 | AP2A_HUMAN | Activator protein 2 | Homo | <M><L><W><K><L><T><D><N><I><K><Y><E><D><C><E><D><R><H><D><G><T><S><N><G><T><A><R><L><P><Q><L><G><T><V><G><Q><S><P><Y><T><S><A><P><P><L><S><H><T><P><N><A><D><F><Q><P><P><Y><F><P><P><P><Y><Q><P><I><Y><P><Q><S><Q><D><P><Y><S><H><V><N><D><P><Y><S><L><N><P><L><H><A><Q><P><Q><P><Q><H><P><G><W><P><G><Q><R><Q><S><Q><E><S><G><L><L><H><T><H><R><G><L><P><H><Q><L><S><G><L><D><P><R><R><D><Y><R><R><H><E><D><L><L><H><G><P><H><A><L><S><S><G><L><G><D><L><S><I><H><S><L><P><H><A><I><E><E><V><P><H><V><E><D><P><G><I><N><I><P><D><Q><T><V><I><K><K><G><P><V><S><L><S><K><S><N><S><N><A><V><S><A><I><P><I><N><K><D><N><L><F><G><G><V><V><N><P><N><E><V><F><C><S><V><P><G><R><L><S><L><L><S><S><T><S><K><Y><K><V><T><V><A><E><V><Q><R><R><L><S><P><P><E><C><L><N><A><S><L><L><G><G><V><L><R><R><A><K><S><K><N><G><G><R><S><L><R><E><K><L><D><K><I><G><L><N><L><P><A><G><R><R><K><A><A><N><V><T><L><L><T><S><L><V><E><G><E><A><V><H><L><A><R><D><F><G><Y><V><C><E><T><E><F><P><A><K><A><V><A><E><F><L><N><R><Q><H><S><D><P><N><E><Q><V><T><R><K><N><M><L><L><A><T><K><Q><I><C><K><E><F><T><D><L><L><A><Q><D><R><S><P><L><G><N><S><R><P><N><P><I><L><E><P><G><I><Q><S><C><L><T><H><F><N><L><I><S><H><G><F><G><S><P><A><V><C><A><A><V><T><A><L><Q><N><Y><L><T><E><A><L><K><A><M><D><K><M><Y><L><S><N><N><P><N><S><H><T><D><N><N><A><K><S><S><D><K><E><E><K><H><R><K> | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.<BOP> | P05549 |
Q5H9I0 | TFDP3_HUMAN | Hepatocellular carcinoma-associated antigen 661 | Homo | <M><A><K><Y><V><S><L><T><E><A><N><E><E><L><K><V><L><M><D><E><N><Q><T><S><R><P><V><A><V><H><T><S><T><V><N><P><L><G><K><Q><L><L><P><K><T><F><G><Q><S><S><V><N><I><D><Q><Q><V><V><I><G><M><P><Q><R><P><A><A><S><N><I><P><V><V><G><S><P><N><P><P><S><T><H><F><A><S><Q><N><Q><H><S><Y><S><S><P><P><W><A><G><Q><H><N><R><K><G><E><K><N><G><M><G><L><C><R><L><S><M><K><V><W><E><T><V><Q><R><K><G><T><T><S><C><Q><E><V><V><G><E><L><V><A><K><F><R><A><A><S><N><H><A><S><P><N><E><S><A><Y><D><V><K><N><I><K><R><R><T><Y><D><A><L><N><V><L><M><A><M><N><I><I><S><R><E><K><K><K><I><K><W><I><G><L><T><T><N><S><A><Q><N><C><Q><N><L><R><V><E><R><Q><K><R><L><E><R><I><K><Q><K><Q><S><E><L><Q><Q><L><I><L><Q><Q><I><A><F><K><N><L><V><L><R><N><Q><Y><V><E><E><Q><V><S><Q><R><P><L><P><N><S><V><I><H><V><P><F><I><I><I><S><S><S><K><K><T><V><I><N><C><S><I><S><D><D><K><S><E><Y><L><F><K><F><N><S><S><F><E><I><H><D><D><T><E><V><L><M><W><M><G><M><T><F><G><L><E><S><G><S><C><S><A><E><D><L><K><M><A><R><N><L><V><P><K><A><L><E><P><Y><V><T><E><M><A><Q><G><T><F><G><G><V><F><T><T><A><G><S><R><S><N><G><T><W><L><S><A><S><D><L><T><N><I><A><I><G><M><L><A><T><S><S><G><G><S><Q><Y><S><G><S><R><V><E><T><P><A><V><E><E><E><E><E><E><D><N><N><D><D><D><L><S><E><N><D><E><D><D> | Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.<BOP> | Q5H9I0 |
O00566 | MPP10_HUMAN | M phase phosphoprotein 10 | Homo | <M><A><P><Q><V><W><R><R><R><T><L><E><R><C><L><T><E><V><G><K><A><T><G><R><P><E><C><F><L><T><I><Q><E><G><L><A><S><K><F><T><S><L><T><K><V><L><Y><D><F><N><K><I><L><E><N><G><R><I><H><G><S><P><L><Q><K><L><V><I><E><N><F><D><D><E><Q><I><W><Q><Q><L><E><L><Q><N><E><P><I><L><Q><Y><F><Q><N><A><V><S><E><T><I><N><D><E><D><I><S><L><L><P><E><S><E><E><Q><E><R><E><E><D><G><S><E><I><E><A><D><D><K><E><D><L><E><D><L><E><E><E><E><V><S><D><M><G><N><D><D><P><E><M><G><E><R><A><E><N><S><S><K><S><D><L><R><K><S><P><V><F><S><D><E><D><S><D><L><D><F><D><I><S><K><L><E><Q><Q><S><K><V><Q><N><K><G><Q><G><K><P><R><E><K><S><I><V><D><D><K><F><F><K><L><S><E><M><E><A><Y><L><E><N><I><E><K><E><E><E><R><K><D><D><N><D><E><E><E><E><D><I><D><F><F><E><D><I><D><S><D><E><D><E><G><G><L><F><G><S><K><K><L><K><S><G><K><S><S><R><N><L><K><Y><K><D><F><F><D><P><V><E><S><D><E><D><I><T><N><V><H><D><D><E><L><D><S><N><K><E><D><D><E><I><A><E><E><E><A><E><E><L><S><I><S><E><T><D><E><D><D><D><L><Q><E><N><E><D><N><K><Q><H><K><E><S><L><K><R><V><T><F><A><L><P><D><D><A><E><T><E><D><T><G><V><L><N><V><K><K><N><S><D><E><V><K><S><S><F><E><K><R><Q><E><K><M><N><E><K><I><A><S><L><E><K><E><L><L><E><K><K><P><W><Q><L><Q><G><E><V><T><A><Q><K><R><P><E><N><S><L><L><E><E><T><L><H><F><D><H><A><V><R><M><A><P><V><I><T><E><E><T><T><L><Q><L><E><D><I><I><K><Q><R><I><R><D><Q><A><W><D><D><V><V><R><K><E><K><P><K><E><D><A><Y><E><Y><K><K><R><L><T><L><D><H><E><K><S><K><L><S><L><A><E><I><Y><E><Q><E><Y><I><K><L><N><Q><Q><K><T><A><E><E><E><N><P><E><H><V><E><I><Q><K><M><M><D><S><L><F><L><K><L><D><A><L><S><N><F><H><F><I><P><K><P><P><V><P><E><I><K><V><V><S><N><L><P><A><I><T><M><E><E><V><A><P><V><S><V><S><D><A><A><L><L><A><P><E><E><I><K><E><K><N><K><A><G><D><I><K><T><A><A><E><K><T><A><T><D><K><K><R><E><R><R><K><K><K><Y><Q><K><R><M><K><I><K><E><K><E><K><R><R><K><L><L><E><K><S><S><V><D><Q><A><G><K><Y><S><K><T><V><A><S><E><K><L><K><Q><L><T><K><T><G><K><A><S><F><I><K><D><E><G><K><D><K><A><L><K><S><S><Q><A><F><F><S><K><L><Q><D><Q><V><K><M><Q><I><N><D><A><K><K><T><E><K><K><K><K><K><R><Q><D><I><S><V><H><K><L><K><L> | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.<BOP> | O00566 |
Q6NXT2 | H3C_HUMAN | Histone H3.5 | Homo | <M><A><R><T><K><Q><T><A><R><K><S><T><G><G><K><A><P><R><K><Q><L><A><T><K><A><A><R><K><S><T><P><S><T><C><G><V><K><P><H><R><Y><R><P><G><T><V><A><L><R><E><I><R><R><Y><Q><K><S><T><E><L><L><I><R><K><L><P><F><Q><R><L><V><R><E><I><A><Q><D><F><N><T><D><L><R><F><Q><S><A><A><V><G><A><L><Q><E><A><S><E><A><Y><L><V><G><L><L><E><D><T><N><L><C><A><I><H><A><K><R><V><T><I><M><P><K><D><I><Q><L><A><R><R><I><R><G><E><R><A> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.<BOP> | Q6NXT2 |
P27695 | APEX1_HUMAN | DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial | Homo | <M><P><K><R><G><K><K><G><A><V><A><E><D><G><D><E><L><R><T><E><P><E><A><K><K><S><K><T><A><A><K><K><N><D><K><E><A><A><G><E><G><P><A><L><Y><E><D><P><P><D><Q><K><T><S><P><S><G><K><P><A><T><L><K><I><C><S><W><N><V><D><G><L><R><A><W><I><K><K><K><G><L><D><W><V><K><E><E><A><P><D><I><L><C><L><Q><E><T><K><C><S><E><N><K><L><P><A><E><L><Q><E><L><P><G><L><S><H><Q><Y><W><S><A><P><S><D><K><E><G><Y><S><G><V><G><L><L><S><R><Q><C><P><L><K><V><S><Y><G><I><G><D><E><E><H><D><Q><E><G><R><V><I><V><A><E><F><D><S><F><V><L><V><T><A><Y><V><P><N><A><G><R><G><L><V><R><L><E><Y><R><Q><R><W><D><E><A><F><R><K><F><L><K><G><L><A><S><R><K><P><L><V><L><C><G><D><L><N><V><A><H><E><E><I><D><L><R><N><P><K><G><N><K><K><N><A><G><F><T><P><Q><E><R><Q><G><F><G><E><L><L><Q><A><V><P><L><A><D><S><F><R><H><L><Y><P><N><T><P><Y><A><Y><T><F><W><T><Y><M><M><N><A><R><S><K><N><V><G><W><R><L><D><Y><F><L><L><S><H><S><L><L><P><A><L><C><D><S><K><I><R><S><K><A><L><G><S><D><H><C><P><I><T><L><Y><L><A><L> | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role | P27695 |
Q9H306 | MMP27_HUMAN | Matrix metalloproteinase-27 | Homo | <M><K><R><L><L><L><L><F><L><F><F><I><T><F><S><S><A><F><P><L><V><R><M><T><E><N><E><E><N><M><Q><L><A><Q><A><Y><L><N><Q><F><Y><S><L><E><I><E><G><N><H><L><V><Q><S><K><N><R><S><L><I><D><D><K><I><R><E><M><Q><A><F><F><G><L><T><V><T><G><K><L><D><S><N><T><L><E><I><M><K><T><P><R><C><G><V><P><D><V><G><Q><Y><G><Y><T><L><P><G><W><R><K><Y><N><L><T><Y><R><I><I><N><Y><T><P><D><M><A><R><A><A><V><D><E><A><I><Q><E><G><L><E><V><W><S><K><V><T><P><L><K><F><T><K><I><S><K><G><I><A><D><I><M><I><A><F><R><T><R><V><H><G><R><C><P><R><Y><F><D><G><P><L><G><V><L><G><H><A><F><P><P><G><P><G><L><G><G><D><T><H><F><D><E><D><E><N><W><T><K><D><G><A><G><F><N><L><F><L><V><A><A><H><E><F><G><H><A><L><G><L><S><H><S><N><D><Q><T><A><L><M><F><P><N><Y><V><S><L><D><P><R><K><Y><P><L><S><Q><D><D><I><N><G><I><Q><S><I><Y><G><G><L><P><K><E><P><A><K><P><K><E><P><T><I><P><H><A><C><D><P><D><L><T><F><D><A><I><T><T><F><R><R><E><V><M><F><F><K><G><R><H><L><W><R><I><Y><Y><D><I><T><D><V><E><F><E><L><I><A><S><F><W><P><S><L><P><A><D><L><Q><A><A><Y><E><N><P><R><D><K><I><L><V><F><K><D><E><N><F><W><M><I><R><G><Y><A><V><L><P><D><Y><P><K><S><I><H><T><L><G><F><P><G><R><V><K><K><I><D><A><A><V><C><D><K><T><T><R><K><T><Y><F><F><V><G><I><W><C><W><R><F><D><E><M><T><Q><T><M><D><K><G><F><P><Q><R><V><V><K><H><F><P><G><I><S><I><R><V><D><A><A><F><Q><Y><K><G><F><F><F><F><S><R><G><S><K><Q><F><E><Y><D><I><K><T><K><N><I><T><R><I><M><R><T><N><T><W><F><Q><C><K><E><P><K><N><S><S><F><G><F><D><I><N><K><E><K><A><H><S><G><G><I><K><I><L><Y><H><K><S><L><S><L><F><I><F><G><I><V><H><L><L><K><N><T><S><I><Y><Q> | Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.<BOP> | Q9H306 |
Q9H790 | EXO5_HUMAN | Defects in morphology protein 1 homolog | Homo | <M><A><E><T><R><E><E><E><T><V><S><A><E><A><S><G><F><S><D><L><S><D><S><E><F><L><E><F><L><D><L><E><D><A><Q><E><S><K><A><L><V><N><M><P><G><P><S><S><E><S><L><G><K><D><D><K><P><I><S><L><Q><N><W><K><R><G><L><D><I><L><S><P><M><E><R><F><H><L><K><Y><L><Y><V><T><D><L><A><T><Q><N><W><C><E><L><Q><T><A><Y><G><K><E><L><P><G><F><L><A><P><E><K><A><A><V><L><D><T><G><A><S><I><H><L><A><R><E><L><E><L><H><D><L><V><T><V><P><V><T><T><K><E><D><A><W><A><I><K><F><L><N><I><L><L><L><I><P><T><L><Q><S><E><G><H><I><R><E><F><P><V><F><G><E><G><E><G><V><L><L><V><G><V><I><D><E><L><H><Y><T><A><K><G><E><L><E><L><A><E><L><K><T><R><R><R><P><M><L><P><L><E><A><Q><K><K><K><D><C><F><Q><V><S><L><Y><K><Y><I><F><D><A><M><V><Q><G><K><V><T><P><A><S><L><I><H><H><T><K><L><C><L><E><K><P><L><G><P><S><V><L><R><H><A><Q><Q><G><G><F><S><V><K><S><L><G><D><L><M><E><L><V><F><L><S><L><T><L><S><D><L><P><V><I><D><I><L><K><I><E><Y><I><H><Q><E><T><A><T><V><L><G><T><E><I><V><A><F><K><E><K><E><V><R><A><K><V><Q><H><Y><M><A><Y><W><M><G><H><R><E><P><Q><G><V><D><V><E><E><A><W><K><C><R><T><C><T><Y><A><D><I><C><E><W><R><K><G><S><G><V><L><S><S><T><L><A><P><Q><V><K><K><A><K> | Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.<BOP> | Q9H790 |
O60909 | B4GT2_HUMAN | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2 | Homo | <M><S><R><L><L><G><G><T><L><E><R><V><C><K><A><V><L><L><L><C><L><L><H><F><L><V><A><V><I><L><Y><F><D><V><Y><A><Q><H><L><A><F><F><S><R><F><S><A><R><G><P><A><H><A><L><H><P><A><A><S><S><S><S><S><S><S><N><C><S><R><P><N><A><T><A><S><S><S><G><L><P><E><V><P><S><A><L><P><G><P><T><A><P><T><L><P><P><C><P><D><S><P><P><G><L><V><G><R><L><L><I><E><F><T><S><P><M><P><L><E><R><V><Q><R><E><N><P><G><V><L><M><G><G><R><Y><T><P><P><D><C><T><P><A><Q><T><V><A><V><I><I><P><F><R><H><R><E><H><H><L><R><Y><W><L><H><Y><L><H><P><I><L><R><R><Q><R><L><R><Y><G><V><Y><V><I><N><Q><H><G><E><D><T><F><N><R><A><K><L><L><N><V><G><F><L><E><A><L><K><E><D><A><A><Y><D><C><F><I><F><S><D><V><D><L><V><P><M><D><D><R><N><L><Y><R><C><G><D><Q><P><R><H><F><A><I><A><M><D><K><F><G><F><R><L><P><Y><A><G><Y><F><G><G><V><S><G><L><S><K><A><Q><F><L><R><I><N><G><F><P><N><E><Y><W><G><W><G><G><E><D><D><D><I><F><N><R><I><S><L><T><G><M><K><I><S><R><P><D><I><R><I><G><R><Y><R><M><I><K><H><D><R><D><K><H><N><E><P><N><P><Q><R><F><T><K><I><Q><N><T><K><L><T><M><K><R><D><G><I><G><S><V><R><Y><Q><V><L><E><V><S><R><Q><P><L><F><T><N><I><T><V><D><I><G><R><P><P><S><W><P><P><R><G> | Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids . Can produce lactose .<BOP> | O60909 |
A6NJ78 | MET15_HUMAN | Methyltransferase-like protein 15 | Homo | <M><L><R><Y><P><Y><F><C><R><M><Y><K><E><C><L><S><C><W><L><E><S><G><I><P><N><L><G><V><W><P><N><R><I><H><T><T><A><E><K><Y><R><E><Y><E><A><R><E><Q><T><D><Q><T><Q><A><Q><E><L><H><R><S><Q><D><R><D><F><E><T><M><A><K><L><H><I><P><V><M><V><D><E><V><V><H><C><L><S><P><Q><K><G><Q><I><F><L><D><M><T><F><G><S><G><G><H><T><K><A><I><L><Q><K><E><S><D><I><V><L><Y><A><L><D><R><D><P><T><A><Y><A><L><A><E><H><L><S><E><L><Y><P><K><Q><I><R><A><M><L><G><Q><F><S><Q><A><E><A><L><L><M><K><A><G><V><Q><P><G><T><F><D><G><V><L><M><D><L><G><C><S><S><M><Q><L><D><T><P><E><R><G><F><S><L><R><K><D><G><P><L><D><M><R><M><D><G><G><R><Y><P><D><M><P><T><A><A><D><V><V><N><A><L><D><Q><Q><A><L><A><S><I><L><R><T><Y><G><E><E><K><H><A><K><K><I><A><S><A><I><V><Q><A><R><S><I><Y><P><I><T><R><T><Q><Q><L><A><S><I><V><A><G><A><F><P><P><S><A><I><Y><T><R><K><D><L><L><Q><R><S><T><H><I><A><T><K><T><F><Q><A><L><R><I><F><V><N><N><E><L><N><E><L><Y><T><G><L><K><T><A><Q><K><F><L><R><P><G><G><R><L><V><A><L><S><F><H><S><L><E><D><R><I><V><K><R><F><L><L><G><I><S><M><T><E><R><F><N><L><S><V><R><Q><Q><V><M><K><T><S><Q><L><G><S><D><H><E><N><T><E><E><V><S><M><R><R><A><P><L><M><W><E><L><I><H><K><K><V><L><S><P><Q><D><Q><D><V><Q><D><N><P><R><G><R><S><A><K><L><R><A><A><I><K><L> | N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA . Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits .<BOP> | A6NJ78 |
Q5T013 | HYI_HUMAN | Endothelial cell apoptosis protein E-CE1 | Homo | <M><A><P><L><R><F><S><A><N><L><S><W><L><F><P><E><L><S><G><L><P><A><R><V><R><A><A><G><S><S><G><F><E><A><V><E><V><A><W><P><Y><A><E><T><P><E><A><L><A><R><A><A><R><E><A><G><L><R><L><V><L><I><N><T><P><P><G><D><Q><E><K><G><E><M><G><L><G><A><V><P><G><R><Q><A><A><F><R><E><G><L><E><Q><A><V><R><Y><A><K><A><L><G><C><P><R><I><H><L><M><A><G><R><V><P><Q><G><A><D><R><I><A><V><K><A><E><M><E><A><V><F><L><E><N><L><R><H><A><A><G><V><L><A><Q><E><D><L><V><G><L><L><E><P><I><N><T><R><I><T><D><P><Q><Y><F><L><D><T><P><Q><Q><A><A><A><I><L><Q><K><V><G><R><P><N><L><Q><L><Q><M><D><I><F><H><W><Q><I><M><D><G><N><L><T><G><N><I><R><E><F><L><P><I><V><G><H><V><Q><V><A><Q><V><P><G><R><G><E><P><S><S><P><G><E><L><N><F><P><Y><L><F><Q><L><L><E><D><E><G><Y><K><G><F><V><G><C><E><Y><Q><P><R><G><D><T><V><E><G><L><S><W><L><R><S><Y><W><D><R><R><G><H><P><E><A><G><Q> | Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).<BOP> | Q5T013 |
Q2T9L4 | INSY1_HUMAN | Inhibitory synaptic factor 1 | Homo | <M><N><I><R><G><A><P><D><L><G><Q><P><S><D><D><P><S><S><G><G><E><R><E><R><I><R><Q><R><M><K><M><V><I><G><Q><L><E><G><I><L><R><E><L><K><E><V><A><K><E><L><R><E><V><V><S><Q><I><D><K><L><T><S><D><F><D><F><E><L><E><P><D><D><W><T><T><A><T><V><S><S><T><S><S><S><D><K><A><G><M><G><G><P><F><D><L><G><H><L><D><F><M><T><A><D><I><L><S><D><S><W><E><F><C><S><F><L><D><V><S><T><P><S><D><S><V><D><G><P><E><S><T><R><P><G><A><G><P><D><Y><R><L><M><N><G><G><T><P><I><P><N><G><P><R><V><E><T><P><D><S><S><S><E><E><A><F><G><A><G><P><T><V><K><S><Q><L><P><Q><R><T><P><G><T><R><E><R><V><R><F><S><D><K><V><L><Y><H><A><L><C><C><D><D><E><E><G><D><G><E><Q><E><V><E><E><E><E><V><G><L><P><P><E><P><A><H><T><E><A><H><A><G><P><H><K><P><S><P><A><P><Y><K><S><R><R><S><P><L><T><S><R><H><S><G><S><T><L><A><P><E><Q><T><R><R><V><T><R><N><S><S><T><Q><T><V><S><D><K><S><T><Q><T><V><L><P><Y><T><A><T><R><Q><K><A><R><G><K><N> | Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.<BOP> | Q2T9L4 |
O43889 | CREB3_HUMAN | Processed cyclic AMP-responsive element-binding protein 3 | Homo | <M><E><L><E><L><D><A><G><D><Q><D><L><L><A><F><L><L><E><E><S><G><D><L><G><T><A><P><D><E><A><V><R><A><P><L><D><W><A><L><P><L><S><E><V><P><S><D><W><E><V><D><D><L><L><C><S><L><L><S><P><P><A><S><L><N><I><L><S><S><S><N><P><C><L><V><H><H><D><H><T><Y><S><L><P><R><E><T><V><S><M><D><L><E><S><E><S><C><R><K><E><G><T><Q><M><T><P><Q><H><M><E><E><L><A><E><Q><E><I><A><R><L><V><L><T><D><E><E><K><S><L><L><E><K><E><G><L><I><L><P><E><T><L><P><L><T><K><T><E><E><Q><I><L><K><R><V><R><R><K><I><R><N><K><R><S><A><Q><E><S><R><R><K><K><K><V><Y><V><G><G><L><E><S><R><V><L><K><Y><T><A><Q><N><M><E><L><Q><N><K><V><Q><L><L><E><E><Q><N><L><S><L><L><D><Q><L><R><K><L><Q><A><M><V><I><E><I><S><N><K><T><S><S><S><S><T><C><I><L><V><L><L><V><S><F><C><L><L><L><V><P><A><M><Y><S><S><D><T><R><G><S><L><P><A><E><H><G><V><L><S><R><Q><L><R><A><L><P><S><E><D><P><Y><Q><L><E><L><P><A><L><Q><S><E><V><P><K><D><S><T><H><Q><W><L><D><G><S><D><C><V><L><Q><A><P><G><N><T><S><C><L><L><H><Y><M><P><Q><A><P><S><A><E><P><P><L><E><W><P><F><P><D><L><F><S><E><P><L><C><R><G><P><I><L><P><L><Q><A><N><L><T><R><K><G><G><W><L><P><T><G><S><P><S><V><I><L><Q><D><R><Y><S><G> | (Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.<BOP> | O43889 |
Q9BUI4 | RPC3_HUMAN | RNA polymerase III 62 kDa subunit | Homo | <M><T><Q><A><E><I><K><L><C><S><L><L><L><Q><E><H><F><G><E><I><V><E><K><I><G><V><H><L><I><R><T><G><S><Q><P><L><R><V><I><A><H><D><T><G><T><S><L><D><Q><V><K><K><A><L><C><V><L><V><Q><H><N><L><V><S><Y><Q><V><H><K><R><G><V><V><E><Y><E><A><Q><C><S><R><V><L><R><M><L><R><Y><P><R><Y><I><Y><T><T><K><T><L><Y><S><D><T><G><E><L><I><V><E><E><L><L><L><N><G><K><L><T><M><S><A><V><V><K><K><V><A><D><R><L><T><E><T><M><E><D><G><K><T><M><D><Y><A><E><V><S><N><T><F><V><R><L><A><D><T><H><F><V><Q><R><C><P><S><V><P><T><T><E><N><S><D><P><G><P><P><P><P><A><P><T><L><V><I><N><E><K><D><M><Y><L><V><P><K><L><S><L><I><G><K><G><K><R><R><R><S><S><D><E><D><A><A><G><E><P><K><A><K><R><P><K><Y><T><T><D><N><K><E><P><I><P><D><D><G><I><Y><W><Q><A><N><L><D><R><F><H><Q><H><F><R><D><Q><A><I><V><S><A><V><A><N><R><M><D><Q><T><S><S><E><I><V><R><T><M><L><R><M><S><E><I><T><T><S><S><S><A><P><F><T><Q><P><L><S><S><N><E><I><F><R><S><L><P><V><G><Y><N><I><S><K><Q><V><L><D><Q><Y><L><T><L><L><A><D><D><P><L><E><F><V><G><K><S><G><D><S><G><G><G><M><Y><V><I><N><L><H><K><A><L><A><S><L><A><T><A><T><L><E><S><V><V><Q><E><R><F><G><S><R><C><A><R><I><F><R><L><V><L><Q><K><K><H><I><E><Q><K><Q><V><E><D><F><A><M><I><P><A><K><E><A><K><D><M><L><Y><K><M><L><S><E><N><F><M><S><L><Q><E><I><P><K><T><P><D><H><A><P><S><R><T><F><Y><L><Y><T><V><N><I><L><S><A><A><R><M><L><L><H><R><C><Y><K><S><I><A><N><L><I><E><R><R><Q><F><E><T><K><E><N><K><R><L><L><E><K><S><Q><R><V><E><A><I><I><A><S><M><Q><A><T><G><A><E><E><A><Q><L><Q><E><I><E><E><M><I><T><A><P><E><R><Q><Q><L><E><T><L><K><R><N><V><N><K><L><D><A><S><E><I><Q><V><D><E><T><I><F><L><L><E><S><Y><I><E><C><T><M><K><R><Q> | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner .<BOP> | Q9BUI4 |
Q15019 | SEPT2_HUMAN | Neural precursor cell expressed developmentally down-regulated protein 5 | Homo | <M><S><K><Q><Q><P><T><Q><F><I><N><P><E><T><P><G><Y><V><G><F><A><N><L><P><N><Q><V><H><R><K><S><V><K><K><G><F><E><F><T><L><M><V><V><G><E><S><G><L><G><K><S><T><L><I><N><S><L><F><L><T><D><L><Y><P><E><R><V><I><P><G><A><A><E><K><I><E><R><T><V><Q><I><E><A><S><T><V><E><I><E><E><R><G><V><K><L><R><L><T><V><V><D><T><P><G><Y><G><D><A><I><N><C><R><D><C><F><K><T><I><I><S><Y><I><D><E><Q><F><E><R><Y><L><H><D><E><S><G><L><N><R><R><H><I><I><D><N><R><V><H><C><C><F><Y><F><I><S><P><F><G><H><G><L><K><P><L><D><V><A><F><M><K><A><I><H><N><K><V><N><I><V><P><V><I><A><K><A><D><T><L><T><L><K><E><R><E><R><L><K><K><R><I><L><D><E><I><E><E><H><N><I><K><I><Y><H><L><P><D><A><E><S><D><E><D><E><D><F><K><E><Q><T><R><L><L><K><A><S><I><P><F><S><V><V><G><S><N><Q><L><I><E><A><K><G><K><K><V><R><G><R><L><Y><P><W><G><V><V><E><V><E><N><P><E><H><N><D><F><L><K><L><R><T><M><L><I><T><H><M><Q><D><L><Q><E><V><T><Q><D><L><H><Y><E><N><F><R><S><E><R><L><K><R><G><G><R><K><V><E><N><E><D><M><N><K><D><Q><I><L><L><E><K><E><A><E><L><R><R><M><Q><E><M><I><A><R><M><Q><A><Q><M><Q><M><Q><M><Q><G><G><D><G><D><G><G><A><L><G><H><H><V> | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May | Q15019 |
O75469 | NR1I2_HUMAN | Steroid and xenobiotic receptor | Homo | <M><E><V><R><P><K><E><S><W><N><H><A><D><F><V><H><C><E><D><T><E><S><V><P><G><K><P><S><V><N><A><D><E><E><V><G><G><P><Q><I><C><R><V><C><G><D><K><A><T><G><Y><H><F><N><V><M><T><C><E><G><C><K><G><F><F><R><R><A><M><K><R><N><A><R><L><R><C><P><F><R><K><G><A><C><E><I><T><R><K><T><R><R><Q><C><Q><A><C><R><L><R><K><C><L><E><S><G><M><K><K><E><M><I><M><S><D><E><A><V><E><E><R><R><A><L><I><K><R><K><K><S><E><R><T><G><T><Q><P><L><G><V><Q><G><L><T><E><E><Q><R><M><M><I><R><E><L><M><D><A><Q><M><K><T><F><D><T><T><F><S><H><F><K><N><F><R><L><P><G><V><L><S><S><G><C><E><L><P><E><S><L><Q><A><P><S><R><E><E><A><A><K><W><S><Q><V><R><K><D><L><C><S><L><K><V><S><L><Q><L><R><G><E><D><G><S><V><W><N><Y><K><P><P><A><D><S><G><G><K><E><I><F><S><L><L><P><H><M><A><D><M><S><T><Y><M><F><K><G><I><I><S><F><A><K><V><I><S><Y><F><R><D><L><P><I><E><D><Q><I><S><L><L><K><G><A><A><F><E><L><C><Q><L><R><F><N><T><V><F><N><A><E><T><G><T><W><E><C><G><R><L><S><Y><C><L><E><D><T><A><G><G><F><Q><Q><L><L><L><E><P><M><L><K><F><H><Y><M><L><K><K><L><Q><L><H><E><E><E><Y><V><L><M><Q><A><I><S><L><F><S><P><D><R><P><G><V><L><Q><H><R><V><V><D><Q><L><Q><E><Q><F><A><I><T><L><K><S><Y><I><E><C><N><R><P><Q><P><A><H><R><F><L><F><L><K><I><M><A><M><L><T><E><L><R><S><I><N><A><Q><H><T><Q><R><L><L><R><I><Q><D><I><H><P><F><A><T><P><L><M><Q><E><L><F><G><I><T><G><S> | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<BOP> | O75469 |
P08263 | GSTA1_HUMAN | Glutathione S-transferase A1, N-terminally processed | Homo | <M><A><E><K><P><K><L><H><Y><F><N><A><R><G><R><M><E><S><T><R><W><L><L><A><A><A><G><V><E><F><E><E><K><F><I><K><S><A><E><D><L><D><K><L><R><N><D><G><Y><L><M><F><Q><Q><V><P><M><V><E><I><D><G><M><K><L><V><Q><T><R><A><I><L><N><Y><I><A><S><K><Y><N><L><Y><G><K><D><I><K><E><R><A><L><I><D><M><Y><I><E><G><I><A><D><L><G><E><M><I><L><L><L><P><V><C><P><P><E><E><K><D><A><K><L><A><L><I><K><E><K><I><K><N><R><Y><F><P><A><F><E><K><V><L><K><S><H><G><Q><D><Y><L><V><G><N><K><L><S><R><A><D><I><H><L><V><E><L><L><Y><Y><V><E><E><L><D><S><S><L><I><S><S><F><P><L><L><K><A><L><K><T><R><I><S><N><L><P><T><V><K><K><F><L><Q><P><G><S><P><R><K><P><P><M><D><E><K><S><L><E><E><A><R><K><I><F><R><F> | Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) . It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis . Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid .<BOP> | P08263 |
Q9BQ83 | SLX1_HUMAN | GIY-YIG domain-containing protein 1 | Homo | <M><G><P><A><G><V><A><A><R><P><G><R><F><F><G><V><Y><L><L><Y><C><L><N><P><R><Y><R><G><R><V><Y><V><G><F><T><V><N><T><A><R><R><V><Q><Q><H><N><G><G><R><K><K><G><G><A><W><R><T><S><G><R><G><P><W><E><M><V><L><V><V><H><G><F><P><S><S><V><A><A><L><R><F><E><W><A><W><Q><H><P><H><A><S><R><R><L><A><H><V><G><P><R><L><R><G><E><T><A><F><A><F><H><L><R><V><L><A><H><M><L><R><A><P><P><W><A><R><L><P><L><T><L><R><W><V><R><P><D><L><R><Q><D><L><C><L><P><P><P><P><H><V><P><L><A><F><G><P><P><P><P><Q><A><P><A><P><R><R><R><A><G><P><F><D><D><A><E><P><E><P><D><Q><G><D><P><G><A><C><C><S><L><C><A><Q><T><I><Q><D><E><E><G><P><L><C><C><P><H><P><G><C><L><L><R><A><H><V><I><C><L><A><E><E><F><L><Q><E><E><P><G><Q><L><L><P><L><E><G><Q><C><P><C><C><E><K><S><L><L><W><G><D><L><I><W><L><C><Q><M><D><T><E><K><E><V><E><D><S><E><L><E><E><A><H><W><T><D><L><L><E><T> | Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.<BOP> | Q9BQ83 |
Q8WUM9 | S20A1_HUMAN | Solute carrier family 20 member 1 | Homo | <M><A><T><L><I><T><S><T><T><A><A><T><A><A><S><G><P><L><V><D><Y><L><W><M><L><I><L><G><F><I><I><A><F><V><L><A><F><S><V><G><A><N><D><V><A><N><S><F><G><T><A><V><G><S><G><V><V><T><L><K><Q><A><C><I><L><A><S><I><F><E><T><V><G><S><V><L><L><G><A><K><V><S><E><T><I><R><K><G><L><I><D><V><E><M><Y><N><S><T><Q><G><L><L><M><A><G><S><V><S><A><M><F><G><S><A><V><W><Q><L><V><A><S><F><L><K><L><P><I><S><G><T><H><C><I><V><G><A><T><I><G><F><S><L><V><A><K><G><Q><E><G><V><K><W><S><E><L><I><K><I><V><M><S><W><F><V><S><P><L><L><S><G><I><M><S><G><I><L><F><F><L><V><R><A><F><I><L><H><K><A><D><P><V><P><N><G><L><R><A><L><P><V><F><Y><A><C><T><V><G><I><N><L><F><S><I><M><Y><T><G><A><P><L><L><G><F><D><K><L><P><L><W><G><T><I><L><I><S><V><G><C><A><V><F><C><A><L><I><V><W><F><F><V><C><P><R><M><K><R><K><I><E><R><E><I><K><C><S><P><S><E><S><P><L><M><E><K><K><N><S><L><K><E><D><H><E><E><T><K><L><S><V><G><D><I><E><N><K><H><P><V><S><E><V><G><P><A><T><V><P><L><Q><A><V><V><E><E><R><T><V><S><F><K><L><G><D><L><E><E><A><P><E><R><E><R><L><P><S><V><D><L><K><E><E><T><S><I><D><S><T><V><N><G><A><V><Q><L><P><N><G><N><L><V><Q><F><S><Q><A><V><S><N><Q><I><N><S><S><G><H><Y><Q><Y><H><T><V><H><K><D><S><G><L><Y><K><E><L><L><H><K><L><H><L><A><K><V><G><D><C><M><G><D><S><G><D><K><P><L><R><R><N><N><S><Y><T><S><Y><T><M><A><I><C><G><M><P><L><D><S><F><R><A><K><E><G><E><Q><K><G><E><E><M><E><K><L><T><W><P><N><A><D><S><K><K><R><I><R><M><D><S><Y><T><S><Y><C><N><A><V><S><D><L><H><S><A><S><E><I><D><M><S><V><K><A><E><M><G><L><G><D><R><K><G><S><N><G><S><L><E><E><W><Y><D><Q><D><K><P><E><V><S><L><L><F><Q><F><L><Q><I><L><T><A><C><F><G><S><F><A><H><G><G><N><D><V><S><N><A><I><G><P><L><V><A><L><Y><L><V><Y><D><T><G><D><V><S><S><K><V><A><T><P><I><W><L><L><L><Y><G><G><V><G><I><C><V><G><L><W><V><W><G><R><R><V><I><Q><T><M><G><K><D><L><T><P><I><T><P><S><S><G><F><S><I><E><L><A><S><A><L><T><V><V><I><A><S><N><I><G><L><P><I><S><T><T><H><C><K><V><G><S><V><V><S><V><G><W><L><R><S><K><K><A><V><D><W><R><L><F><R><N><I><F><M><A><W><F><V><T><V><P><I><S><G><V><I><S><A><A><I><M><A><I><F><R><Y><V><I><L><R><M> | (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV).<BOP> | Q8WUM9 |
Q5J5C9 | DB121_HUMAN | Defensin, beta 121 | Homo | <M><K><L><L><L><L><L><L><T><V><T><L><L><L><A><Q><V><T><P><V><M><K><C><W><G><K><S><G><R><C><R><T><T><C><K><E><S><E><V><Y><Y><I><L><C><K><T><E><A><K><C><C><V><D><P><K><Y><V><P><V><K><P><K><L><T><D><T><N><T><S><L><E><S><T><S><A><V> | Has antibacterial activity.<BOP> | Q5J5C9 |
P15882 | CHIN_HUMAN | Rho GTPase-activating protein 2 | Homo | <M><A><L><T><L><F><D><T><D><E><Y><R><P><P><V><W><K><S><Y><L><Y><Q><L><Q><Q><E><A><P><H><P><R><R><I><T><C><T><C><E><V><E><N><R><P><K><Y><Y><G><R><E><F><H><G><M><I><S><R><E><A><A><D><Q><L><L><I><V><A><E><G><S><Y><L><I><R><E><S><Q><R><Q><P><G><T><Y><T><L><A><L><R><F><G><S><Q><T><R><N><F><R><L><Y><Y><D><G><K><H><F><V><G><E><K><R><F><E><S><I><H><D><L><V><T><D><G><L><I><T><L><Y><I><E><T><K><A><A><E><Y><I><A><K><M><T><I><N><P><I><Y><E><H><V><G><Y><T><T><L><N><R><E><P><A><Y><K><K><H><M><P><V><L><K><E><T><H><D><E><R><D><S><T><G><Q><D><G><V><S><E><K><R><L><T><S><L><V><R><R><A><T><L><K><E><N><E><Q><I><P><K><Y><E><K><I><H><N><F><K><V><H><T><F><R><G><P><H><W><C><E><Y><C><A><N><F><M><W><G><L><I><A><Q><G><V><K><C><A><D><C><G><L><N><V><H><K><Q><C><S><K><M><V><P><N><D><C><K><P><D><L><K><H><V><K><K><V><Y><S><C><D><L><T><T><L><V><K><A><H><T><T><K><R><P><M><V><V><D><M><C><I><R><E><I><E><S><R><G><L><N><S><E><G><L><Y><R><V><S><G><F><S><D><L><I><E><D><V><K><M><A><F><D><R><D><G><E><K><A><D><I><S><V><N><M><Y><E><D><I><N><I><I><T><G><A><L><K><L><Y><F><R><D><L><P><I><P><L><I><T><Y><D><A><Y><P><K><F><I><E><S><A><K><I><M><D><P><D><E><Q><L><E><T><L><H><E><A><L><K><L><L><P><P><A><H><C><E><T><L><R><Y><L><M><A><H><L><K><R><V><T><L><H><E><K><E><N><L><M><N><A><E><N><L><G><I><V><F><G><P><T><L><M><R><S><P><E><L><D><A><M><A><A><L><N><D><I><R><Y><Q><R><L><V><V><E><L><L><I><K><N><E><D><I><L><F> | GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.<BOP> | P15882 |
Q5JNZ3 | ZN311_HUMAN | Zinc finger protein zfp-31 | Homo | <M><Q><E><V><V><L><L><D><E><S><S><G><P><P><S><Q><L><L><W><T><R><Q><D><T><Q><L><P><Q><E><S><A><L><L><P><A><P><Y><P><A><F><T><K><D><G><S><Q><G><N><L><P><Q><A><D><I><T><L><M><S><Q><A><Q><E><S><V><T><F><E><D><V><A><V><N><F><T><N><R><E><W><Q><C><L><T><Y><A><Q><R><H><L><Y><K><D><V><M><L><E><N><Y><G><N><M><V><S><L><G><F><P><F><P><K><P><P><L><I><S><H><L><E><R><E><V><D><P><C><V><Q><D><P><Q><D><R><E><S><L><S><C><S><Y><P><V><S><A><D><K><M><W><P><E><N><E><K><A><S><S><Q><Q><E><I><F><E><N><G><E><A><Y><W><M><K><F><N><S><L><L><K><V><D><S><R><D><P><K><V><R><E><V><C><V><Q><D><V><K><L><E><N><Q><W><E><T><S><I><R><E><K><L><R><E><E><K><E><G><S><E><E><V><T><C><K><K><G><K><N><Q><K><V><L><S><K><N><L><N><P><N><S><K><H><S><Q><C><N><K><V><L><I><A><Q><K><L><H><E><C><A><R><C><G><K><N><F><S><W><H><S><D><L><I><L><H><E><Q><I><H><S><G><E><K><P><H><V><C><N><E><C><G><K><A><F><K><T><R><N><Q><L><S><M><H><R><I><I><H><T><G><E><K><P><F><N><C><T><Q><C><G><K><A><F><N><S><R><S><A><L><C><R><H><K><K><T><H><S><G><E><K><P><H><E><C><R><D><C><G><K><A><F><K><T><R><N><R><L><C><M><H><Q><L><I><H><T><G><E><K><P><Y><K><C><N><C><C><G><K><A><F><Q><F><K><H><S><L><T><I><H><G><R><I><H><T><G><E><K><P><Y><E><C><E><E><C><G><K><A><F><S><G><S><S><D><L><T><K><H><I><R><I><H><T><G><E><R><P><Y><E><C><S><K><C><G><R><A><F><S><R><S><S><D><L><S><K><H><K><R><I><H><T><R><E><K><H><Y><G><C><P><Q><C><G><K><D><F><S><I><K><A><E><L><T><K><H><R><R><I><H><T><E><E><K><R><Y><R><C><E><E><C><G><K><A><F><R><H><N><C><K><R><R><A><H><E><R><E><H><T><G><E><K><P><Y><Q><C><R><D><C><G><K><T><F><Q><D><K><H><C><L><T><I><H><Q><R><I><H><T><G><E><K><P><Y><K><C><L><E><C><G><K><A><F><S><G><K><S><N><L><T><N><H><R><R><I><H><T><G><E><K><P><H><K><C><E><V><C><G><M><A><F><H><H><S><S><V><L><R><Q><H><K><R><I><H><T><G><E><K><P><Y><T><C><S><E><C><G><T><S><F><R><Q><G><S><A><L><I><G><H><K><R><V><H><T><G><E><K><P><Y><E><C><E><E><C><G><K><A><F><R><V><S><S><N><L><T><G><H><K><K><R><K><H><Q><V><W><S><T><H><E><L><D><G><S><R><K><S><L><S><P><V><T><V><S><Q><T><S><V><V><S><I><L><T><S><A> | May be involved in transcriptional regulation.<BOP> | Q5JNZ3 |
O95476 | CNEP1_HUMAN | Serine/threonine-protein phosphatase dullard | Homo | <M><M><R><T><Q><C><L><L><G><L><R><T><F><V><A><F><A><A><K><L><W><S><F><F><I><Y><L><L><R><R><Q><I><R><T><V><I><Q><Y><Q><T><V><R><Y><D><I><L><P><L><S><P><V><S><R><N><R><L><A><Q><V><K><R><K><I><L><V><L><D><L><D><E><T><L><I><H><S><H><H><D><G><V><L><R><P><T><V><R><P><G><T><P><P><D><F><I><L><K><V><V><I><D><K><H><P><V><R><F><F><V><H><K><R><P><H><V><D><F><F><L><E><V><V><S><Q><W><Y><E><L><V><V><F><T><A><S><M><E><I><Y><G><S><A><V><A><D><K><L><D><N><S><R><S><I><L><K><R><R><Y><Y><R><Q><H><C><T><L><E><L><G><S><Y><I><K><D><L><S><V><V><H><S><D><L><S><S><I><V><I><L><D><N><S><P><G><A><Y><R><S><H><P><D><N><A><I><P><I><K><S><W><F><S><D><P><S><D><T><A><L><L><N><L><L><P><M><L><D><A><L><R><F><T><A><D><V><R><S><V><L><S><R><N><L><H><Q><H><R><L><W> | Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.<BOP> | O95476 |
Q8N4G2 | ARL14_HUMAN | ADP-ribosylation factor 7 | Homo | <M><G><S><L><G><S><K><N><P><Q><T><K><Q><A><Q><V><L><L><L><G><L><D><S><A><G><K><S><T><L><L><Y><K><L><K><L><A><K><D><I><T><T><I><P><T><I><G><F><N><V><E><M><I><E><L><E><R><N><L><S><L><T><V><W><D><V><G><G><Q><E><K><M><R><T><V><W><G><C><Y><C><E><N><T><D><G><L><V><Y><V><V><D><S><T><D><K><Q><R><L><E><E><S><Q><R><Q><F><E><H><I><L><K><N><E><H><I><K><N><V><P><V><V><L><L><A><N><K><Q><D><M><P><G><A><L><T><A><E><D><I><T><R><M><F><K><V><K><K><L><C><S><D><R><N><W><Y><V><Q><P><C><C><A><L><T><G><E><G><L><A><Q><G><F><R><K><L><T><G><F><V><K><S><H><M><K><S><R><G><D><T><L><A><F><F><K><Q><N> | GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.<BOP> | Q8N4G2 |
Q9BPW9 | DHRS9_HUMAN | Tracheobronchial epithelial cell-specific retinol dehydrogenase | Homo | <M><L><F><W><V><L><G><L><L><I><L><C><G><F><L><W><T><R><K><G><K><L><K><I><E><D><I><T><D><K><Y><I><F><I><T><G><C><D><S><G><F><G><N><L><A><A><R><T><F><D><K><K><G><F><H><V><I><A><A><C><L><T><E><S><G><S><T><A><L><K><A><E><T><S><E><R><L><R><T><V><L><L><D><V><T><D><P><E><N><V><K><R><T><A><Q><W><V><K><N><Q><V><G><E><K><G><L><W><G><L><I><N><N><A><G><V><P><G><V><L><A><P><T><D><W><L><T><L><E><D><Y><R><E><P><I><E><V><N><L><F><G><L><I><S><V><T><L><N><M><L><P><L><V><K><K><A><Q><G><R><V><I><N><V><S><S><V><G><G><R><L><A><I><V><G><G><G><Y><T><P><S><K><Y><A><V><E><G><F><N><D><S><L><R><R><D><M><K><A><F><G><V><H><V><S><C><I><E><P><G><L><F><K><T><N><L><A><D><P><V><K><V><I><E><K><K><L><A><I><W><E><Q><L><S><P><D><I><K><Q><Q><Y><G><E><G><Y><I><E><K><S><L><D><K><L><K><G><N><K><S><Y><V><N><M><D><L><S><P><V><V><E><C><M><D><H><A><L><T><S><L><F><P><K><T><H><Y><A><A><G><K><D><A><K><I><F><W><I><P><L><S><H><M><P><A><A><L><Q><D><F><L><L><L><K><Q><K><A><E><L><A><N><P><K><A><V> | 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone . Also plays a role in the biosynthesis of retinoic acid from retinaldehyde . Can utilize both NADH and NADPH.<BOP> | Q9BPW9 |
P38567 | HYALP_HUMAN | Sperm surface protein PH-20 | Homo | <M><G><V><L><K><F><K><H><I><F><F><R><S><F><V><K><S><S><G><V><S><Q><I><V><F><T><F><L><L><I><P><C><C><L><T><L><N><F><R><A><P><P><V><I><P><N><V><P><F><L><W><A><W><N><A><P><S><E><F><C><L><G><K><F><D><E><P><L><D><M><S><L><F><S><F><I><G><S><P><R><I><N><A><T><G><Q><G><V><T><I><F><Y><V><D><R><L><G><Y><Y><P><Y><I><D><S><I><T><G><V><T><V><N><G><G><I><P><Q><K><I><S><L><Q><D><H><L><D><K><A><K><K><D><I><T><F><Y><M><P><V><D><N><L><G><M><A><V><I><D><W><E><E><W><R><P><T><W><A><R><N><W><K><P><K><D><V><Y><K><N><R><S><I><E><L><V><Q><Q><Q><N><V><Q><L><S><L><T><E><A><T><E><K><A><K><Q><E><F><E><K><A><G><K><D><F><L><V><E><T><I><K><L><G><K><L><L><R><P><N><H><L><W><G><Y><Y><L><F><P><D><C><Y><N><H><H><Y><K><K><P><G><Y><N><G><S><C><F><N><V><E><I><K><R><N><D><D><L><S><W><L><W><N><E><S><T><A><L><Y><P><S><I><Y><L><N><T><Q><Q><S><P><V><A><A><T><L><Y><V><R><N><R><V><R><E><A><I><R><V><S><K><I><P><D><A><K><S><P><L><P><V><F><A><Y><T><R><I><V><F><T><D><Q><V><L><K><F><L><S><Q><D><E><L><V><Y><T><F><G><E><T><V><A><L><G><A><S><G><I><V><I><W><G><T><L><S><I><M><R><S><M><K><S><C><L><L><L><D><N><Y><M><E><T><I><L><N><P><Y><I><I><N><V><T><L><A><A><K><M><C><S><Q><V><L><C><Q><E><Q><G><V><C><I><R><K><N><W><N><S><S><D><Y><L><H><L><N><P><D><N><F><A><I><Q><L><E><K><G><G><K><F><T><V><R><G><K><P><T><L><E><D><L><E><Q><F><S><E><K><F><Y><C><S><C><Y><S><T><L><S><C><K><E><K><A><D><V><K><D><T><D><A><V><D><V><C><I><A><D><G><V><C><I><D><A><F><L><K><P><P><M><E><T><E><E><P><Q><I><F><Y><N><A><S><P><S><T><L><S><A><T><M><F><I><V><S><I><L><F><L><I><I><S><S><V><A><S><L> | Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.<BOP> | P38567 |
Q9Y5Z0 | BACE2_HUMAN | Theta-secretase | Homo | <M><G><A><L><A><R><A><L><L><L><P><L><L><A><Q><W><L><L><R><A><A><P><E><L><A><P><A><P><F><T><L><P><L><R><V><A><A><A><T><N><R><V><V><A><P><T><P><G><P><G><T><P><A><E><R><H><A><D><G><L><A><L><A><L><E><P><A><L><A><S><P><A><G><A><A><N><F><L><A><M><V><D><N><L><Q><G><D><S><G><R><G><Y><Y><L><E><M><L><I><G><T><P><P><Q><K><L><Q><I><L><V><D><T><G><S><S><N><F><A><V><A><G><T><P><H><S><Y><I><D><T><Y><F><D><T><E><R><S><S><T><Y><R><S><K><G><F><D><V><T><V><K><Y><T><Q><G><S><W><T><G><F><V><G><E><D><L><V><T><I><P><K><G><F><N><T><S><F><L><V><N><I><A><T><I><F><E><S><E><N><F><F><L><P><G><I><K><W><N><G><I><L><G><L><A><Y><A><T><L><A><K><P><S><S><S><L><E><T><F><F><D><S><L><V><T><Q><A><N><I><P><N><V><F><S><M><Q><M><C><G><A><G><L><P><V><A><G><S><G><T><N><G><G><S><L><V><L><G><G><I><E><P><S><L><Y><K><G><D><I><W><Y><T><P><I><K><E><E><W><Y><Y><Q><I><E><I><L><K><L><E><I><G><G><Q><S><L><N><L><D><C><R><E><Y><N><A><D><K><A><I><V><D><S><G><T><T><L><L><R><L><P><Q><K><V><F><D><A><V><V><E><A><V><A><R><A><S><L><I><P><E><F><S><D><G><F><W><T><G><S><Q><L><A><C><W><T><N><S><E><T><P><W><S><Y><F><P><K><I><S><I><Y><L><R><D><E><N><S><S><R><S><F><R><I><T><I><L><P><Q><L><Y><I><Q><P><M><M><G><A><G><L><N><Y><E><C><Y><R><F><G><I><S><P><S><T><N><A><L><V><I><G><A><T><V><M><E><G><F><Y><V><I><F><D><R><A><Q><K><R><V><G><F><A><A><S><P><C><A><E><I><A><G><A><A><V><S><E><I><S><G><P><F><S><T><E><D><V><A><S><N><C><V><P><A><Q><S><L><S><E><P><I><L><W><I><V><S><Y><A><L><M><S><V><C><G><A><I><L><L><V><L><I><V><L><L><L><L><P><F><R><C><Q><R><R><P><R><D><P><E><V><V><N><D><E><S><S><L><V><R><H><R><W><K> | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 . Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets . Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells .<BOP> | Q9Y5Z0 |
Q9BWV2 | SPAT9_HUMAN | Testis development protein NYD-SP16 | Homo | <M><P><I><K><P><V><G><W><I><C><G><Q><V><L><K><N><F><S><G><R><I><E><G><I><Q><K><A><I><M><D><L><V><D><E><F><K><D><E><F><P><T><I><L><R><L><S><Q><S><N><Q><K><R><E><P><A><Q><K><T><S><K><I><R><M><A><I><A><L><A><K><I><N><R><A><T><L><I><R><G><L><N><S><I><S><R><S><S><K><S><V><A><K><L><L><H><P><Q><L><A><C><R><L><L><E><L><R><D><I><S><G><R><L><L><R><E><V><N><A><P><R><Q><P><L><Y><N><I><Q><V><R><K><G><S><L><F><E><I><I><S><F><P><A><K><T><A><L><T><S><I><I><Y><A><S><Y><A><A><L><I><Y><L><A><V><C><V><N><A><V><L><K><K><V><K><N><I><F><Q><E><E><E><S><I><R><Q><N><R><E><E><S><E><N><C><R><K><A><F><S><E><P><V><L><S><E><P><M><F><A><E><G><E><I><K><A><K><P><Y><R><S><L><P><E><K><P><D><I><S><D><Y><P><K><L><L><A><N><K><Q><S><N><N><I><Q><V><L><H><S><V><F><D><Q><S><A><E><M><N><E><Q><I> | May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.<BOP> | Q9BWV2 |
Q9NPJ6 | MED4_HUMAN | Vitamin D3 receptor-interacting protein complex 36 kDa component | Homo | <M><A><A><S><S><S><G><E><K><E><K><E><R><L><G><G><G><L><G><V><A><G><G><N><S><T><R><E><R><L><L><S><A><L><E><D><L><E><V><L><S><R><E><L><I><E><M><L><A><I><S><R><N><Q><K><L><L><Q><A><G><E><E><N><Q><V><L><E><L><L><I><H><R><D><G><E><F><Q><E><L><M><K><L><A><L><N><Q><G><K><I><H><H><E><M><Q><V><L><E><K><E><V><E><K><R><D><S><D><I><Q><Q><L><Q><K><Q><L><K><E><A><E><Q><I><L><A><T><A><V><Y><Q><A><K><E><K><L><K><S><I><E><K><A><R><K><G><A><I><S><S><E><E><I><I><K><Y><A><H><R><I><S><A><S><N><A><V><C><A><P><L><T><W><V><P><G><D><P><R><R><P><Y><P><T><D><L><E><M><R><S><G><L><L><G><Q><M><N><N><P><S><T><N><G><V><N><G><H><L><P><G><D><A><L><A><A><G><R><L><P><D><V><L><A><P><Q><Y><P><W><Q><S><N><D><M><S><M><N><M><L><P><P><N><H><S><S><D><F><L><L><E><P><P><G><H><N><K><E><N><E><D><D><V><E><I><M><S><T><D><S><S><S><S><S><S><E><S><D> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP> | Q9NPJ6 |
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