accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q96SB4
SRPK1_HUMAN
Serine/arginine-rich protein-specific kinase 1
Homo
<M><E><R><K><V><L><A><L><Q><A><R><K><K><R><T><K><A><K><K><D><K><A><Q><R><K><S><E><T><Q><H><R><G><S><A><P><H><S><E><S><D><L><P><E><Q><E><E><E><I><L><G><S><D><D><D><E><Q><E><D><P><N><D><Y><C><K><G><G><Y><H><L><V><K><I><G><D><L><F><N><G><R><Y><H><V><I><R><K><L><G><W><G><H><F><S><T><V><W><L><S><W><D><I><Q><G><K><K><F><V><A><M><K><V><V><K><S><A><E><H><Y><T><E><T><A><L><D><E><I><R><L><L><K><S><V><R><N><S><D><P><N><D><P><N><R><E><M><V><V><Q><L><L><D><D><F><K><I><S><G><V><N><G><T><H><I><C><M><V><F><E><V><L><G><H><H><L><L><K><W><I><I><K><S><N><Y><Q><G><L><P><L><P><C><V><K><K><I><I><Q><Q><V><L><Q><G><L><D><Y><L><H><T><K><C><R><I><I><H><T><D><I><K><P><E><N><I><L><L><S><V><N><E><Q><Y><I><R><R><L><A><A><E><A><T><E><W><Q><R><S><G><A><P><P><P><S><G><S><A><V><S><T><A><P><Q><P><K><P><A><D><K><M><S><K><N><K><K><K><K><L><K><K><K><Q><K><R><Q><A><E><L><L><E><K><R><M><Q><E><I><E><E><M><E><K><E><S><G><P><G><Q><K><R><P><N><K><Q><E><E><S><E><S><P><V><E><R><P><L><K><E><N><P><P><N><K><M><T><Q><E><K><L><E><E><S><S><T><I><G><Q><D><Q><T><L><M><E><R><D><T><E><G><G><A><A><E><I><N><C><N><G><V><I><E><V><I><N><Y><T><Q><N><S><N><N><E><T><L><R><H><K><E><D><L><H><N><A><N><D><C><D><V><Q><N><L><N><Q><E><S><S><F><L><S><S><Q><N><G><D><S><S><T><S><Q><E><T><D><S><C><T><P><I><T><S><E><V><S><D><T><M><V><C><Q><S><S><S><T><V><G><Q><S><F><S><E><Q><H><I><S><Q><L><Q><E><S><I><R><A><E><I><P><C><E><D><E><Q><E><Q><E><H><N><G><P><L><D><N><K><G><K><S><T><A><G><N><F><L><V><N><P><L><E><P><K><N><A><E><K><L><K><V><K><I><A><D><L><G><N><A><C><W><V><H><K><H><F><T><E><D><I><Q><T><R><Q><Y><R><S><L><E><V><L><I><G><S><G><Y><N><T><P><A><D><I><W><S><T><A><C><M><A><F><E><L><A><T><G><D><Y><L><F><E><P><H><S><G><E><E><Y><T><R><D><E><D><H><I><A><L><I><I><E><L><L><G><K><V><P><R><K><L><I><V><A><G><K><Y><S><K><E><F><F><T><K><K><G><D><L><K><H><I><T><K><L><K><P><W><G><L><F><E><V><L><V><E><K><Y><E><W><S><Q><E><E><A><A><G><F><T><D><F><L><L><P><M><L><E><L><I><P><E><K><R><A><T><A><A><E><C><L><R><H><P><W><L><N><S>
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SR
Q96SB4
Q9UHV2
SRTD1_HUMAN
Transcriptional regulator interacting with the PHD-bromodomain 1
Homo
<M><L><S><K><G><L><K><R><K><R><E><E><E><E><E><K><E><P><L><A><V><D><S><W><W><L><D><P><G><H><T><A><V><A><Q><A><P><P><A><V><A><S><S><S><L><F><D><L><S><V><L><K><L><H><H><S><L><Q><Q><S><E><P><D><L><R><H><L><V><L><V><V><N><T><L><R><R><I><Q><A><S><M><A><P><A><A><A><L><P><P><V><P><S><P><P><A><A><P><S><V><A><D><N><L><L><A><S><S><D><A><A><L><S><A><S><M><A><S><L><L><E><D><L><S><H><I><E><G><L><S><Q><A><P><Q><P><L><A><D><E><G><P><P><G><R><S><I><G><G><A><A><P><S><L><G><A><L><D><L><L><G><P><A><T><G><C><L><L><D><D><G><L><E><G><L><F><E><D><I><D><T><S><M><Y><D><N><E><L><W><A><P><A><S><E><G><L><K><P><G><P><E><D><G><P><G><K><E><E><A><P><E><L><D><E><A><E><L><D><Y><L><M><D><V><L><V><G><T><Q><A><L><E><R><P><P><G><P><G><R>
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.<BOP>
Q9UHV2
Q9HCP6
HHATL_HUMAN
Hedgehog acyltransferase-like protein
Homo
<M><G><I><K><T><A><L><P><A><A><E><L><G><L><Y><S><L><V><L><S><G><A><L><A><Y><A><G><R><G><L><L><E><A><S><Q><D><G><A><H><R><K><A><F><R><E><S><V><R><P><G><W><E><Y><I><G><R><K><M><D><V><A><D><F><E><W><V><M><W><F><T><S><F><R><N><V><I><I><F><A><L><S><G><H><V><L><F><A><K><L><C><T><M><V><A><P><K><L><R><S><W><M><Y><A><V><Y><G><A><L><A><V><M><G><T><M><G><P><W><Y><L><L><L><L><L><G><H><C><V><G><L><Y><V><A><S><L><L><G><Q><P><W><L><C><L><G><L><G><L><A><S><L><A><S><F><K><M><D><P><L><I><S><W><Q><S><G><F><V><T><G><T><F><D><L><Q><E><V><L><F><H><G><G><S><S><F><T><V><L><R><C><T><S><F><A><L><E><S><C><A><H><P><D><R><H><Y><S><L><A><D><L><L><K><Y><N><F><Y><L><P><F><F><F><F><G><P><I><M><T><F><D><R><F><H><A><Q><V><S><Q><V><E><P><V><R><R><E><G><E><L><W><H><I><R><A><Q><A><G><L><S><V><V><A><I><M><A><V><D><I><F><F><H><F><F><Y><I><L><T><I><P><S><D><L><K><F><A><N><R><L><P><D><S><A><L><A><G><L><A><Y><S><N><L><V><Y><D><W><V><K><A><A><V><L><F><G><V><V><N><T><V><A><C><L><D><H><L><D><P><P><Q><P><P><K><C><I><T><A><L><Y><V><F><A><E><T><H><F><D><R><G><I><N><D><W><L><C><K><Y><V><Y><N><H><I><G><G><E><H><S><A><V><I><P><E><L><A><A><T><V><A><T><F><A><I><T><T><L><W><L><G><P><C><D><I><V><Y><L><W><S><F><L><N><C><F><G><L><N><F><E><L><W><M><Q><K><L><A><E><W><G><P><L><A><R><I><E><A><S><L><S><V><Q><M><S><R><R><V><R><A><L><F><G><A><M><N><F><W><A><I><I><M><Y><N><L><V><S><L><N><S><L><K><F><T><E><L><V><A><R><R><L><L><L><T><G><F><P><Q><T><T><L><S><I><L><F><V><T><Y><C><G><V><Q><L><V><K><E><R><E><R><T><L><A><L><E><E><E><Q><K><Q><D><K><E><K><P><E>
Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.<BOP>
Q9HCP6
Q9H9H4
VP37B_HUMAN
ESCRT-I complex subunit VPS37B
Homo
<M><A><G><A><G><S><E><A><R><F><A><G><L><S><L><V><Q><L><N><E><L><L><E><D><E><G><Q><L><T><E><M><V><Q><K><M><E><E><T><Q><N><V><Q><L><N><K><E><M><T><L><A><S><N><R><S><L><A><E><G><N><L><L><Y><Q><P><Q><L><D><T><L><K><A><R><L><T><Q><K><Y><Q><E><L><Q><V><L><F><E><A><Y><Q><I><K><K><T><K><L><D><R><Q><S><S><S><A><S><L><E><T><L><L><A><L><L><Q><A><E><G><A><K><I><E><E><D><T><E><N><M><A><E><K><F><L><D><G><E><L><P><L><D><S><F><I><D><V><Y><Q><S><K><R><K><L><A><H><M><R><R><V><K><I><E><K><L><Q><E><M><V><L><K><G><Q><R><L><P><Q><A><L><A><P><L><P><P><R><L><P><E><L><A><P><T><A><P><L><P><Y><P><A><P><E><A><S><G><P><P><A><V><A><P><R><R><I><P><P><P><P><P><P><V><P><A><G><R><L><A><T><P><F><T><A><A><M><S><S><G><Q><A><V><P><Y><P><G><L><Q><C><P><P><L><P><P><R><V><G><L><P><T><Q><Q><G><F><S><S><Q><F><V><S><P><Y><P><P><P><L><P><Q><R><P><P><P><R><L><P><P><H><Q><P><G><F><I><L><Q>
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.<BOP>
Q9H9H4
Q01664
TFAP4_HUMAN
Class C basic helix-loop-helix protein 41
Homo
<M><E><Y><F><M><V><P><T><Q><K><V><P><S><L><Q><H><F><R><K><T><E><K><E><V><I><G><G><L><C><S><L><A><N><I><P><L><T><P><E><T><Q><R><D><Q><E><R><R><I><R><R><E><I><A><N><S><N><E><R><R><R><M><Q><S><I><N><A><G><F><Q><S><L><K><T><L><I><P><H><T><D><G><E><K><L><S><K><A><A><I><L><Q><Q><T><A><E><Y><I><F><S><L><E><Q><E><K><T><R><L><L><Q><Q><N><T><Q><L><K><R><F><I><Q><E><L><S><G><S><S><P><K><R><R><R><A><E><D><K><D><E><G><I><G><S><P><D><I><W><E><D><E><K><A><E><D><L><R><R><E><M><I><E><L><R><Q><Q><L><D><K><E><R><S><V><R><M><M><L><E><E><Q><V><R><S><L><E><A><H><M><Y><P><E><K><L><K><V><I><A><Q><Q><V><Q><L><Q><Q><Q><Q><E><Q><V><R><L><L><H><Q><E><K><L><E><R><E><Q><Q><Q><L><R><T><Q><L><L><P><P><P><A><P><T><H><H><P><T><V><I><V><P><A><P><P><P><P><P><S><H><H><I><N><V><V><T><M><G><P><S><S><V><I><N><S><V><S><T><S><R><Q><N><L><D><T><I><V><Q><A><I><Q><H><I><E><G><T><Q><E><K><Q><E><L><E><E><E><Q><R><R><A><V><I><V><K><P><V><R><S><C><P><E><A><P><T><S><D><T><A><S><D><S><E><A><S><D><S><D><A><M><D><Q><S><R><E><E><P><S><G><D><G><E><L><P>
Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.<BOP>
Q01664
Q9P287
BCCIP_HUMAN
Protein TOK-1
Homo
<M><A><S><R><S><K><R><R><A><V><E><S><G><V><P><Q><P><P><D><P><P><V><Q><R><D><E><E><E><E><K><E><V><E><N><E><D><E><D><D><D><D><S><D><K><E><K><D><E><E><D><E><V><I><D><E><E><V><N><I><E><F><E><A><Y><S><L><S><D><N><D><Y><D><G><I><K><K><L><L><Q><Q><L><F><L><K><A><P><V><N><T><A><E><L><T><D><L><L><I><Q><Q><N><H><I><G><S><V><I><K><Q><T><D><V><S><E><D><S><N><D><D><M><D><E><D><E><V><F><G><F><I><S><L><L><N><L><T><E><R><K><G><T><Q><C><V><E><Q><I><Q><E><L><V><L><R><F><C><E><K><N><C><E><K><S><M><V><E><Q><L><D><K><F><L><N><D><T><T><K><P><V><G><L><L><L><S><E><R><F><I><N><V><P><P><Q><I><A><L><P><M><Y><Q><Q><L><Q><K><E><L><A><G><A><H><R><T><N><K><P><C><G><K><C><Y><F><Y><L><L><I><S><K><T><F><V><E><A><G><K><N><N><S><K><K><K><P><S><N><K><K><K><A><A><L><M><F><A><N><A><E><E><E><F><F><Y><E><K><A><I><L><K><F><N><Y><S><V><Q><E><E><S><D><T><C><L><G><G><K><W><S><F><D><D><V><P><M><T><P><L><R><T><V><M><L><I><P><G><D><K><M><N><E><I><M><D><K><L><K><E><Y><L><S><V>
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole . Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta . May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).<BOP>
Q9P287
Q3YEC7
RABL6_HUMAN
Rab-like protein 1
Homo
<M><F><S><A><L><K><K><L><V><G><S><D><Q><A><P><G><R><D><K><N><I><P><A><G><L><Q><S><M><N><Q><A><L><Q><R><R><F><A><K><G><V><Q><Y><N><M><K><I><V><I><R><G><D><R><N><T><G><K><T><A><L><W><H><R><L><Q><G><R><P><F><V><E><E><Y><I><P><T><Q><E><I><Q><V><T><S><I><H><W><S><Y><K><T><T><D><D><I><V><K><V><E><V><W><D><V><V><D><K><G><K><C><K><K><R><G><D><G><L><K><M><E><N><D><P><Q><E><A><E><S><E><M><A><L><D><A><E><F><L><D><V><Y><K><N><C><N><G><V><V><M><M><F><D><I><T><K><Q><W><T><F><N><Y><I><L><R><E><L><P><K><V><P><T><H><V><P><V><C><V><L><G><N><Y><R><D><M><G><E><H><R><V><I><L><P><D><D><V><R><D><F><I><D><N><L><D><R><P><P><G><S><S><Y><F><R><Y><A><E><S><S><M><K><N><S><F><G><L><K><Y><L><H><K><F><F><N><I><P><F><L><Q><L><Q><R><E><T><L><L><R><Q><L><E><T><N><Q><L><D><M><D><A><T><L><E><E><L><S><V><Q><Q><E><T><E><D><Q><N><Y><G><I><F><L><E><M><M><E><A><R><S><R><G><H><A><S><P><L><A><A><N><G><Q><S><P><S><P><G><S><Q><S><P><V><V><P><A><G><A><V><S><T><G><S><S><S><P><G><T><P><Q><P><A><P><Q><L><P><L><N><A><A><P><P><S><S><V><P><P><V><P><P><S><E><A><L><P><P><P><A><C><P><S><A><P><A><P><R><R><S><I><I><S><R><L><F><G><T><S><P><A><T><E><A><A><P><P><P><P><E><P><V><P><A><A><E><G><P><A><T><V><Q><S><V><E><D><F><V><P><D><D><R><L><D><R><S><F><L><E><D><T><T><P><A><R><D><E><K><K><V><G><A><K><A><A><Q><Q><D><S><D><S><D><G><E><A><L><G><G><N><P><M><V><A><G><F><Q><D><D><V><D><L><E><D><Q><P><R><G><S><P><P><L><P><A><G><P><V><P><S><Q><D><I><T><L><S><S><E><E><E><A><E><V><A><A><P><T><K><G><P><A><P><A><P><Q><Q><C><S><E><P><E><T><K><W><S><S><I><P><A><S><K><P><R><R><G><T><A><P><T><R><T><A><A><P><P><W><P><G><G><V><S><V><R><T><G><P><E><K><R><S><S><T><R><P><P><A><E><M><E><P><G><K><G><E><Q><A><S><S><S><E><S><D><P><E><G><P><I><A><A><Q><M><L><S><F><V><M><D><D><P><D><F><E><S><E><G><S><D><T><Q><R><R><A><D><D><F><P><V><R><D><D><P><S><D><V><T><D><E><D><E><G><P><A><E><P><P><P><P><P><K><L><P><L><P><A><F><R><L><K><N><D><S><D><L><F><G><L><G><L><E><E><A><G><P><K><E><S><S><E><E><G><K><E><G><K><T><P><S><K><E><K><K><K><K><K><K><K><G><K><E><E><E><E><K><A><A><K><K><K><S><K><H><K><K><S><K><D><K><E><E><G><K><E><E><R><R><R><R><Q><Q><R><P><P><R><S><R><E><R><T><A><A><D><E><L><E><A><F><L><G><G><G><A><P><G><G><R><H><P><G><G><G><D><Y><E><E><L>
May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.<BOP>
Q3YEC7
P50539
MXI1_HUMAN
Class C basic helix-loop-helix protein 11
Homo
<M><E><R><V><K><M><I><N><V><Q><R><L><L><E><A><A><E><F><L><E><R><R><E><R><E><C><E><H><G><Y><A><S><S><F><P><S><M><P><S><P><R><L><Q><H><S><K><P><P><R><R><L><S><R><A><Q><K><H><S><S><G><S><S><N><T><S><T><A><N><R><S><T><H><N><E><L><E><K><N><R><R><A><H><L><R><L><C><L><E><R><L><K><V><L><I><P><L><G><P><D><C><T><R><H><T><T><L><G><L><L><N><K><A><K><A><H><I><K><K><L><E><E><A><E><R><K><S><Q><H><Q><L><E><N><L><E><R><E><Q><R><F><L><K><W><R><L><E><Q><L><Q><G><P><Q><E><M><E><R><I><R><M><D><S><I><G><S><T><I><S><S><D><R><S><D><S><E><R><E><E><I><E><V><D><V><E><S><T><E><F><S><H><G><E><V><D><N><I><S><T><T><S><I><S><D><I><D><D><H><S><S><L><P><S><I><G><S><D><E><G><Y><S><S><A><S><V><K><L><S><F><T><S>
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.<BOP>
P50539
P08651
NFIC_HUMAN
TGGCA-binding protein
Homo
<M><Y><S><S><P><L><C><L><T><Q><D><E><F><H><P><F><I><E><A><L><L><P><H><V><R><A><F><A><Y><T><W><F><N><L><Q><A><R><K><R><K><Y><F><K><K><H><E><K><R><M><S><K><D><E><E><R><A><V><K><D><E><L><L><G><E><K><P><E><V><K><Q><K><W><A><S><R><L><L><A><K><L><R><K><D><I><R><P><E><C><R><E><D><F><V><L><S><I><T><G><K><K><A><P><G><C><V><L><S><N><P><D><Q><K><G><K><M><R><R><I><D><C><L><R><Q><A><D><K><V><W><R><L><D><L><V><M><V><I><L><F><K><G><I><P><L><E><S><T><D><G><E><R><L><V><K><A><A><Q><C><G><H><P><V><L><C><V><Q><P><H><H><I><G><V><A><V><K><E><L><D><L><Y><L><A><Y><F><V><R><E><R><D><A><E><Q><S><G><S><P><R><T><G><M><G><S><D><Q><E><D><S><K><P><I><T><L><D><T><T><D><F><Q><E><S><F><V><T><S><G><V><F><S><V><T><E><L><I><Q><V><S><R><T><P><V><V><T><G><T><G><P><N><F><S><L><G><E><L><Q><G><H><L><A><Y><D><L><N><P><A><S><T><G><L><R><R><T><L><P><S><T><S><S><S><G><S><K><R><H><K><S><G><S><M><E><E><D><V><D><T><S><P><G><G><D><Y><Y><T><S><P><S><S><P><T><S><S><S><R><N><W><T><E><D><M><E><G><G><I><S><S><P><V><K><K><T><E><M><D><K><S><P><F><N><S><P><S><P><Q><D><S><P><R><L><S><S><F><T><Q><H><H><R><P><V><I><A><V><H><S><G><I><A><R><S><P><H><P><S><S><A><L><H><F><P><T><T><S><I><L><P><Q><T><A><S><T><Y><F><P><H><T><A><I><R><Y><P><P><H><L><N><P><Q><D><P><L><K><D><L><V><S><L><A><C><D><P><A><S><Q><Q><P><G><P><L><N><G><S><G><Q><L><K><M><P><S><H><C><L><S><A><Q><M><L><A><P><P><P><P><G><L><P><R><L><A><L><P><P><A><T><K><P><A><T><T><S><E><G><G><A><T><S><P><T><S><P><S><Y><S><P><P><D><T><S><P><A><N><R><S><F><V><G><L><G><P><R><D><P><A><G><I><Y><Q><A><Q><S><W><Y><L><G>
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.<BOP>
P08651
Q16630
CPSF6_HUMAN
Protein HPBRII-4/7
Homo
<M><A><D><G><V><D><H><I><D><I><Y><A><D><V><G><E><E><F><N><Q><E><A><E><Y><G><G><H><D><Q><I><D><L><Y><D><D><V><I><S><P><S><A><N><N><G><D><A><P><E><D><R><D><Y><M><D><T><L><P><P><T><V><G><D><D><V><G><K><G><A><A><P><N><V><V><Y><T><Y><T><G><K><R><I><A><L><Y><I><G><N><L><T><W><W><T><T><D><E><D><L><T><E><A><V><H><S><L><G><V><N><D><I><L><E><I><K><F><F><E><N><R><A><N><G><Q><S><K><G><F><A><L><V><G><V><G><S><E><A><S><S><K><K><L><M><D><L><L><P><K><R><E><L><H><G><Q><N><P><V><V><T><P><C><N><K><Q><F><L><S><Q><F><E><M><Q><S><R><K><T><T><Q><S><G><Q><M><S><G><E><G><K><A><G><P><P><G><G><S><S><R><A><A><F><P><Q><G><G><R><G><R><G><R><F><P><G><A><V><P><G><G><D><R><F><P><G><P><A><G><P><G><G><P><P><P><P><F><P><A><G><Q><T><P><P><R><P><P><L><G><P><P><G><P><P><G><P><P><G><P><P><P><P><G><Q><V><L><P><P><P><L><A><G><P><P><N><R><G><D><R><P><P><P><P><V><L><F><P><G><Q><P><F><G><Q><P><P><L><G><P><L><P><P><G><P><P><P><P><V><P><G><Y><G><P><P><P><G><P><P><P><P><Q><Q><G><P><P><P><P><P><G><P><F><P><P><R><P><P><G><P><L><G><P><P><L><T><L><A><P><P><P><H><L><P><G><P><P><P><G><A><P><P><P><A><P><H><V><N><P><A><F><F><P><P><P><T><N><S><G><M><P><T><S><D><S><R><G><P><P><P><T><D><P><Y><G><R><P><P><P><Y><D><R><G><D><Y><G><P><P><G><R><E><M><D><T><A><R><T><P><L><S><E><A><E><F><E><E><I><M><N><R><N><R><A><I><S><S><S><A><I><S><R><A><V><S><D><A><S><A><G><D><Y><G><S><A><I><E><T><L><V><T><A><I><S><L><I><K><Q><S><K><V><S><A><D><D><R><C><K><V><L><I><S><S><L><Q><D><C><L><H><G><I><E><S><K><S><Y><G><S><G><S><R><R><E><R><S><R><E><R><D><H><S><R><S><R><E><K><S><R><R><H><K><S><R><S><R><D><R><H><D><D><Y><Y><R><E><R><S><R><E><R><E><R><H><R><D><R><D><R><D><R><D><R><E><R><D><R><E><R><E><Y><R><H><R>
(Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).<BOP>
Q16630
Q96A61
TRI52_HUMAN
Tripartite motif-containing protein 52
Homo
<M><A><G><Y><A><T><T><P><S><P><M><Q><T><L><Q><E><E><A><V><C><A><I><C><L><D><Y><F><K><D><P><V><S><I><S><C><G><H><N><F><C><R><G><C><V><T><Q><L><W><S><K><E><D><E><E><D><Q><N><E><E><E><D><E><W><E><E><E><E><D><E><E><A><V><G><A><M><D><G><W><D><G><S><I><R><E><V><L><Y><R><G><N><A><D><E><E><L><F><Q><D><Q><D><D><D><E><L><W><L><G><D><S><G><I><T><N><W><D><N><V><D><Y><M><W><D><E><E><E><E><E><E><E><E><D><Q><D><Y><Y><L><G><G><L><R><P><D><L><R><I><D><V><Y><R><E><E><E><I><L><E><A><Y><D><E><D><E><D><E><E><L><Y><P><D><I><H><P><P><P><S><L><P><L><P><G><Q><F><T><C><P><Q><C><R><K><S><F><T><R><R><S><F><R><P><N><L><Q><L><A><N><M><V><Q><I><I><R><Q><M><C><P><T><P><Y><R><G><N><R><S><N><D><Q><G><M><C><F><K><H><Q><E><A><L><K><L><F><C><E><V><D><K><E><A><I><C><V><V><C><R><E><S><R><S><H><K><Q><H><S><V><L><P><L><E><E><V><V><Q><E><Y><Q><E><I><K><L><E><T><T><L><V><G><I><L><Q><I><E><Q><E><S><I><H><S><K><A><Y><N><Q>
(Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.<BOP>
Q96A61
Q07812
BAX_HUMAN
Bcl-2-like protein 4
Homo
<M><D><G><S><G><E><Q><P><R><G><G><G><P><T><S><S><E><Q><I><M><K><T><G><A><L><L><L><Q><G><F><I><Q><D><R><A><G><R><M><G><G><E><A><P><E><L><A><L><D><P><V><P><Q><D><A><S><T><K><K><L><S><E><C><L><K><R><I><G><D><E><L><D><S><N><M><E><L><Q><R><M><I><A><A><V><D><T><D><S><P><R><E><V><F><F><R><V><A><A><D><M><F><S><D><G><N><F><N><W><G><R><V><V><A><L><F><Y><F><A><S><K><L><V><L><K><A><L><C><T><K><V><P><E><L><I><R><T><I><M><G><W><T><L><D><F><L><R><E><R><L><L><G><W><I><Q><D><Q><G><G><W><D><G><L><L><S><Y><F><G><T><P><T><W><Q><T><V><T><I><F><V><A><G><V><L><T><A><S><L><T><I><W><K><K><M><G>
Plays a role in the mitochondrial apoptotic process . Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) . Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis . Promotes activation of CASP3, and thereby apoptosis .<BOP>
Q07812
P0DMM9
ST1A3_HUMAN
Thermolabile phenol sulfotransferase
Homo
<M><E><L><I><Q><D><T><S><R><P><P><L><E><Y><V><K><G><V><P><L><I><K><Y><F><A><E><A><L><G><P><L><Q><S><F><Q><A><R><P><D><D><L><L><I><N><T><Y><P><K><S><G><T><T><W><V><S><Q><I><L><D><M><I><Y><Q><G><G><D><L><E><K><C><N><R><A><P><I><Y><V><R><V><P><F><L><E><V><N><D><P><G><E><P><S><G><L><E><T><L><K><D><T><P><P><P><R><L><I><K><S><H><L><P><L><A><L><L><P><Q><T><L><L><D><Q><K><V><K><V><V><Y><V><A><R><N><P><K><D><V><A><V><S><Y><Y><H><F><H><R><M><E><K><A><H><P><E><P><G><T><W><D><S><F><L><E><K><F><M><A><G><E><V><S><Y><G><S><W><Y><Q><H><V><Q><E><W><W><E><L><S><R><T><H><P><V><L><Y><L><F><Y><E><D><M><K><E><N><P><K><R><E><I><Q><K><I><L><E><F><V><G><R><S><L><P><E><E><T><M><D><F><M><V><Q><H><T><S><F><K><E><M><K><K><N><P><M><T><N><Y><T><T><V><P><Q><E><L><M><D><H><S><I><S><P><F><M><R><K><G><M><A><G><D><W><K><T><T><F><T><V><A><Q><N><E><R><F><D><A><D><Y><A><E><K><M><A><G><C><S><L><S><F><R><S><E><L>
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.<BOP>
P0DMM9
A6NEQ0
RBY1E_HUMAN
RNA-binding motif protein, Y chromosome, family 1 member E
Homo
<M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G><S><L><R><S><A><R><G><S><R><G><G><T><R><G><W><L><P><S><Q><E><G><H><L><D><D><G><G><Y><T><P><D><L><K><M><S><Y><S><R><G><L><I><P><V><K><R><G><P><S><S><R><S><G><G><P><P><P><K><K><S><A><P><S><A><V><A><R><S><N><S><W><M><G><S><Q><G><P><M><S><Q><R><R><E><N><Y><G><V><P><P><R><R><A><T><I><S><S><W><R><N><D><R><M><S><T><R><H><D><G><Y><A><T><N><D><G><N><H><P><S><C><Q><E><T><R><D><Y><A><P><P><S><R><G><Y><A><Y><R><D><N><G><H><S><N><R><D><E><H><S><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><D><Y><A><P><P><S><R><G><H><A><Y><R><D><Y><G><H><S><R><R><D><E><S><Y><S><R><G><Y><R><N><R><R><S><S><R><E><T><R><E><Y><A><P><P><S><R><G><H><G><Y><R><D><Y><G><H><S><R><R><H><E><S><Y><S><R><G><Y><R><N><H><P><S><S><R><E><T><R><D><Y><A><P><P><H><R><D><Y><A><Y><R><D><Y><G><H><S><S><W><D><E><H><S><S><R><G><Y><S><Y><H><D><G><Y><G><E><A><L><G><R><D><H><S><E><H><L><S><G><S><S><Y><R><D><A><L><Q><R><Y><G><T><A><H><G><A><P><P><A><R><G><P><R><M><S><Y><G><G><S><T><C><H><A><Y><S><N><T><R><D><R><Y><G><R><S><W><E><S><Y><S><S><C><G><D><F><H><Y><C><D><R><E><H><V><C><R><K><D><Q><R><N><P><P><S><L><G><R><V><L><P><D><P><R><E><A><C><G><S><S><S><Y><V><A><S><I><V><D><G><G><E><S><R><S><E><K><G><D><S><S><R><Y>
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.<BOP>
A6NEQ0
Q6IV72
ZN425_HUMAN
Zinc finger protein 425
Homo
<M><A><E><P><A><S><V><T><V><T><F><D><D><V><A><L><Y><F><S><E><Q><E><W><E><I><L><E><K><W><Q><K><Q><M><Y><K><Q><E><M><K><T><N><Y><E><T><L><D><S><L><G><Y><A><F><S><K><P><D><L><I><T><W><M><E><Q><G><R><M><L><L><I><S><E><Q><G><C><L><D><K><T><R><R><T><T><S><P><P><T><D><E><Q><L><N><M><K><N><T><G><K><L><L><C><F><D><D><E><G><T><P><R><T><K><E><E><D><C><R><L><N><G><P><Q><K><Q><D><L><C><A><A><L><R><G><K><E><R><K><I><L><L><A><Q><T><A><T><F><Q><S><P><S><L><R><E><T><E><I><L><N><K><K><V><S><I><T><A><Y><D><P><D><K><K><D><L><R><H><K><P><R><E><T><P><G><R><L><E><I><P><T><G><P><R><C><Y><S><C><Y><V><C><R><K><V><F><Q><V><R><R><D><L><L><K><H><K><R><S><H><S><K><S><Q><L><C><R><Y><P><K><Y><K><N><S><S><R><G><K><S><E><L><R><R><T><Q><R><L><L><C><Q><K><K><R><F><Q><C><S><E><C><E><K><S><Y><F><L><K><G><S><L><V><T><H><Q><V><V><H><T><G><Q><R><P><Y><P><C><P><E><C><D><K><T><F><R><Y><R><A><N><L><K><K><H><L><C><L><H><R><G><E><R><P><F><C><C><G><E><C><G><R><A><F><V><Q><Q><C><E><L><T><E><H><L><R><L><H><S><G><E><K><P><F><Q><C><P><Q><C><D><R><C><F><R><L><K><R><G><M><K><V><H><L><T><Q><H><S><G><K><R><P><F><H><C><P><E><C><G><R><S><F><S><R><K><A><A><L><K><T><H><Q><R><T><H><S><E><E><K><P><F><S><C><G><E><C><G><R><K><F><I><Y><K><I><K><L><D><E><H><I><R><V><H><T><G><E><K><P><F><S><C><P><E><C><N><K><S><F><R><L><K><R><S><L><K><A><H><G><L><Q><H><I><G><K><R><P><F><Q><C><P><E><C><S><R><G><F><F><W><R><N><A><M><R><A><H><Q><R><L><H><S><E><Q><K><P><F><P><C><A><E><C><G><K><R><F><T><R><P><S><K><L><A><C><H><T><R><V><H><D><R><Q><K><E><F><P><C><G><E><C><K><K><T><F><S><Q><Q><S><R><L><T><Q><H><L><K><V><H><T><T><E><K><P><F><S><C><A><E><C><G><R><S><F><R><R><R><A><H><L><T><E><H><T><R><L><H><S><G><E><E><P><F><Q><C><P><E><C><D><K><S><F><S><W><K><A><S><M><K><F><H><Q><R><M><H><R><D><E><K><P><F><A><C><G><E><C><D><K><T><Y><T><H><Q><S><Q><L><T><E><H><L><R><L><H><S><G><E><K><P><Y><Q><C><P><E><C><E><K><T><F><R><L><K><G><N><L><K><S><H><L><L><Q><H><S><G><Q><K><P><F><S><C><V><M><C><G><K><S><F><T><Q><Q><Y><R><L><T><E><H><I><R><V><H><S><G><E><K><P><F><Q><C><P><E><C><D><K><S><Y><C><I><R><G><S><L><K><V><H><L><Y><K><H><S><G><E><R><P><F><Q><C><P><E><C><G><K><G><F><L><Q><K><R><S><L><K><A><H><L><C><L><H><S><G><E><R><P><F><S><C><D><E><C><G><R><S><F><T><Y><V><G><A><L><K><T><H><I><A><V><H><A><K><E><K><P><S><S><L>
Acts as a transcriptional repressor.<BOP>
Q6IV72
Q9NTM9
CUTC_HUMAN
Copper homeostasis protein cutC homolog
Homo
<M><K><R><Q><G><A><S><S><E><R><K><R><A><R><I><P><S><G><K><A><G><A><A><N><G><F><L><M><E><V><C><V><D><S><V><E><S><A><V><N><A><E><R><G><G><A><D><R><I><E><L><C><S><G><L><S><E><G><G><T><T><P><S><M><G><V><L><Q><V><V><K><Q><S><V><Q><I><P><V><F><V><M><I><R><P><R><G><G><D><F><L><Y><S><D><R><E><I><E><V><M><K><A><D><I><R><L><A><K><L><Y><G><A><D><G><L><V><F><G><A><L><T><E><D><G><H><I><D><K><E><L><C><M><S><L><M><A><I><C><R><P><L><P><V><T><F><H><R><A><F><D><M><V><H><D><P><M><A><A><L><E><T><L><L><T><L><G><F><E><R><V><L><T><S><G><C><D><S><S><A><L><E><G><L><P><L><I><K><R><L><I><E><Q><A><K><G><R><I><V><V><M><P><G><G><G><I><T><D><R><N><L><Q><R><I><L><E><G><S><G><A><T><E><F><H><C><S><A><R><S><T><R><D><S><G><M><K><F><R><N><S><S><V><A><M><G><A><S><L><S><C><S><E><Y><S><L><K><V><T><D><V><T><K><V><R><T><L><N><A><I><A><K><N><I><L><V>
May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.<BOP>
Q9NTM9
A6NMN3
F170B_HUMAN
Acrosome-related protein
Homo
<M><K><C><Y><F><T><D><H><R><G><E><Q><S><P><T><D><G><T><T><L><S><L><T><S><P><E><S><T><E><E><S><V><E><V><F><W><P><G><T><I><Q><R><E><G><S><S><P><R><P><G><P><A><I><P><R><E><E><G><L><Y><F><A><A><R><D><R><G><M><R><D><W><S><S><S><P><S><S><E><S><S><E><Y><Q><S><Y><S><Q><Y><Q><S><C><C><S><C><M><C><D><E><D><N><A><A><P><Q><S><V><C><A><F><Y><T><H><V><Q><T><V><R><G><V><A><V><A><W><E><T><E><A><G><F><E><P><V><T><R><K><P><R><I><H><E><A><Q><F><I><K><R><Q><R><W><N><G><S><S><F><E><M><A><S><N><T><D><M><R><W><D><L><E><A><C><K><S><N><C><S><P><E><P><E><D><I><D><L><L><E><C><C><L><Q><E><L><R><E><P><P><D><W><L><V><T><T><N><Y><G><V><R><C><V><A><C><C><R><V><L><P><S><L><D><A><L><L><E><H><A><Q><H><G><I><R><E><G><F><S><C><Q><I><F><F><E><E><M><L><E><R><R><R><A><Q><G><Q><A><H><D><Q><Q><L><E><E><E><Q><S><P><S><D><N><S><E><C><S><R><P><Q><G><E><V><L><S><A><Q><Q><Q><E><K><Q>
Plays a role in fertilization through the acrosome reaction.<BOP>
A6NMN3
O75818
RPP40_HUMAN
RNase P subunit 1
Homo
<M><A><T><L><R><R><L><R><E><A><P><R><H><L><L><V><C><E><K><S><N><F><G><N><H><K><S><R><H><R><H><L><V><Q><T><H><Y><Y><N><Y><R><V><S><F><L><I><P><E><C><G><I><L><S><E><E><L><K><N><L><V><M><N><T><G><P><Y><Y><F><V><K><N><L><P><L><H><E><L><I><T><P><E><F><I><S><T><F><I><K><K><G><S><C><Y><A><L><T><Y><N><T><H><I><D><E><D><N><T><V><A><L><L><P><N><G><K><L><I><L><S><L><D><K><D><T><Y><E><E><T><G><L><Q><G><H><P><S><Q><F><S><G><R><K><I><M><K><F><I><V><S><I><D><L><M><E><L><S><L><N><L><D><S><K><K><Y><E><R><I><S><W><S><F><K><E><K><K><P><L><K><F><D><F><L><L><A><W><H><K><T><G><S><E><E><S><T><M><M><S><Y><F><S><K><Y><Q><I><Q><E><H><Q><P><K><V><A><L><S><T><L><R><D><L><Q><C><P><V><L><Q><S><S><E><L><E><G><T><P><E><V><S><C><R><A><L><E><L><F><D><W><L><G><A><V><F><S><N><V><D><L><N><N><E><P><N><N><F><I><S><T><Y><C><C><P><E><P><S><T><V><V><A><K><A><Y><L><C><T><I><T><G><F><I><L><P><E><K><I><C><L><L><L><E><H><L><C><H><Y><F><D><E><P><K><L><A><P><W><V><T><L><S><V><Q><G><F><A><D><S><P><V><S><W><E><K><N><E><H><G><F><R><K><G><G><E><H><L><Y><N><F><V><I><F><N><N><Q><D><Y><W><L><Q><M><A><V><G><A><N><D><H><C><P><P>
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends . Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences .<BOP>
O75818
Q9UK33
ZN580_HUMAN
LDL-induced EC protein
Homo
<M><L><L><L><P><P><R><P><P><H><P><R><S><S><S><P><E><A><M><D><P><P><P><P><K><A><P><P><F><P><K><A><E><G><P><S><S><T><P><S><S><A><A><G><P><R><P><P><R><L><G><R><H><L><L><I><D><A><N><G><V><P><Y><T><Y><T><V><Q><L><E><E><E><P><R><G><P><P><Q><R><E><A><P><P><G><E><P><G><P><R><K><G><Y><S><C><P><E><C><A><R><V><F><A><S><P><L><R><L><Q><S><H><R><V><S><H><S><D><L><K><P><F><T><C><G><A><C><G><K><A><F><K><R><S><S><H><L><S><R><H><R><A><T><H><R><A><R><A><G><P><P><H><T><C><P><L><C><P><R><R><F><Q><D><A><A><E><L><A><Q><H><V><R><L><H>
Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.<BOP>
Q9UK33
Q96R54
O14A2_HUMAN
Olfactory receptor OR1-31
Homo
<M><A><N><V><T><L><V><T><G><F><L><L><M><G><F><S><N><I><Q><K><L><R><I><L><Y><G><V><L><F><L><L><I><Y><L><A><A><L><M><S><N><L><L><I><I><T><L><I><T><L><D><V><K><L><Q><T><P><M><Y><F><F><L><K><N><L><S><F><L><D><V><F><L><V><S><V><P><I><P><K><F><I><V><N><N><L><T><H><N><N><S><I><S><I><L><G><C><A><F><Q><L><L><L><M><T><S><F><S><A><G><E><I><F><I><L><T><A><M><S><Y><D><R><Y><V><A><I><C><C><P><L><N><Y><E><V><I><M><N><T><G><V><C><V><L><M><A><S><V><S><W><A><I><G><G><L><F><G><T><A><Y><T><A><G><T><F><S><M><P><F><C><G><S><S><V><I><P><Q><F><F><C><D><V><P><S><L><L><R><I><S><C><S><E><T><L><M><V><I><Y><A><G><I><G><V><G><A><C><L><S><I><S><C><F><I><C><I><V><I><S><Y><I><Y><I><F><S><T><V><L><K><I><P><T><T><K><G><Q><S><K><A><F><S><T><C><F><P><H><L><T><V><F><T><V><F><I><I><T><A><Y><F><V><Y><L><K><P><P><S><N><S><P><S><V><I><D><R><L><L><S><V><I><Y><T><V><M><P><P><V><F><N><P><V><T><Y><S><L><R><N><N><D><M><K><C><A><L><I><R><L><L><Q><K><T><Y><G><Q><E><A><Y><F><I>
Odorant receptor.<BOP>
Q96R54
Q8N428
GLT16_HUMAN
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
Homo
<M><R><K><I><R><A><N><A><I><A><I><L><T><V><A><W><I><L><G><T><F><Y><Y><L><W><Q><D><N><R><A><H><A><A><S><S><G><G><R><G><A><Q><R><A><G><R><R><S><E><Q><L><R><E><D><R><T><I><P><L><I><V><T><G><T><P><S><K><G><F><D><E><K><A><Y><L><S><A><K><Q><L><K><A><G><E><D><P><Y><R><Q><H><A><F><N><Q><L><E><S><D><K><L><S><P><D><R><P><I><R><D><T><R><H><Y><S><C><P><S><V><S><Y><S><S><D><L><P><A><T><S><V><I><I><T><F><H><N><E><A><R><S><T><L><L><R><T><V><K><S><V><L><N><R><T><P><A><N><L><I><Q><E><I><I><L><V><D><D><F><S><S><D><P><E><D><C><L><L><L><T><R><I><P><K><V><K><C><L><R><N><D><R><R><E><G><L><I><R><S><R><V><R><G><A><D><V><A><A><A><T><V><L><T><F><L><D><S><H><C><E><V><N><T><E><W><L><P><P><M><L><Q><R><V><K><E><D><H><T><R><V><V><S><P><I><I><D><V><I><S><L><D><N><F><A><Y><L><A><A><S><A><D><L><R><G><G><F><D><W><S><L><H><F><K><W><E><Q><I><P><L><E><Q><K><M><T><R><T><D><P><T><R><P><I><R><T><P><V><I><A><G><G><I><F><V><I><D><K><S><W><F><N><H><L><G><K><Y><D><A><Q><M><D><I><W><G><G><E><N><F><E><L><S><F><R><V><W><M><C><G><G><S><L><E><I><V><P><C><S><R><V><G><H><V><F><R><K><R><H><P><Y><N><F><P><E><G><N><A><L><T><Y><I><R><N><T><K><R><T><A><E><V><W><M><D><E><Y><K><Q><Y><Y><Y><E><A><R><P><S><A><I><G><K><A><F><G><S><V><A><T><R><I><E><Q><R><K><K><M><N><C><K><S><F><R><W><Y><L><E><N><V><Y><P><E><L><T><V><P><V><K><E><A><L><P><G><I><I><K><Q><G><V><N><C><L><E><S><Q><G><Q><N><T><A><G><D><F><L><L><G><M><G><I><C><R><G><S><A><K><N><P><Q><P><A><Q><A><W><L><F><S><D><H><L><I><Q><Q><Q><G><K><C><L><A><A><T><S><T><L><M><S><S><P><G><S><P><V><I><L><Q><M><C><N><P><R><E><G><K><Q><K><W><R><R><K><G><S><F><I><Q><H><S><V><S><G><L><C><L><E><T><K><P><A><Q><L><V><T><S><K><C><Q><A><D><A><Q><A><Q><Q><W><Q><L><L><P><H><T>
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.<BOP>
Q8N428
Q9UBE0
SAE1_HUMAN
SUMO-activating enzyme subunit 1, N-terminally processed
Homo
<M><V><E><K><E><E><A><G><G><G><I><S><E><E><E><A><A><Q><Y><D><R><Q><I><R><L><W><G><L><E><A><Q><K><R><L><R><A><S><R><V><L><L><V><G><L><K><G><L><G><A><E><I><A><K><N><L><I><L><A><G><V><K><G><L><T><M><L><D><H><E><Q><V><T><P><E><D><P><G><A><Q><F><L><I><R><T><G><S><V><G><R><N><R><A><E><A><S><L><E><R><A><Q><N><L><N><P><M><V><D><V><K><V><D><T><E><D><I><E><K><K><P><E><S><F><F><T><Q><F><D><A><V><C><L><T><C><C><S><R><D><V><I><V><K><V><D><Q><I><C><H><K><N><S><I><K><F><F><T><G><D><V><F><G><Y><H><G><Y><T><F><A><N><L><G><E><H><E><F><V><E><E><K><T><K><V><A><K><V><S><Q><G><V><E><D><G><P><D><T><K><R><A><K><L><D><S><S><E><T><T><M><V><K><K><K><V><V><F><C><P><V><K><E><A><L><E><V><D><W><S><S><E><K><A><K><A><A><L><K><R><T><T><S><D><Y><F><L><L><Q><V><L><L><K><F><R><T><D><K><G><R><D><P><S><S><D><T><Y><E><E><D><S><E><L><L><L><Q><I><R><N><D><V><L><D><S><L><G><I><S><P><D><L><L><P><E><D><F><V><R><Y><C><F><S><E><M><A><P><V><C><A><V><V><G><G><I><L><A><Q><E><I><V><K><A><L><S><Q><R><D><P><P><H><N><N><F><F><F><F><D><G><M><K><G><N><G><I><V><E><C><L><G><P><K>
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<BOP>
Q9UBE0
O94952
FBX21_HUMAN
F-box only protein 21
Homo
<M><A><A><A><A><V><D><S><A><M><E><V><V><P><A><L><A><E><E><A><A><P><E><V><A><G><L><S><C><L><V><N><L><P><G><E><V><L><E><Y><I><L><C><C><G><S><L><T><A><A><D><I><G><R><V><S><S><T><C><R><R><L><R><E><L><C><Q><S><S><G><K><V><W><K><E><Q><F><R><V><R><W><P><S><L><M><K><H><Y><S><P><T><D><Y><V><N><W><L><E><E><Y><K><V><R><Q><K><A><G><L><E><A><R><K><I><V><A><S><F><S><K><R><F><F><S><E><H><V><P><C><N><G><F><S><D><I><E><N><L><E><G><P><E><I><F><F><E><D><E><L><V><C><I><L><N><M><E><G><R><K><A><L><T><W><K><Y><Y><A><K><K><I><L><Y><Y><L><R><Q><Q><K><I><L><N><N><L><K><A><F><L><Q><Q><P><D><D><Y><E><S><Y><L><E><G><A><V><Y><I><D><Q><Y><C><N><P><L><S><D><I><S><L><K><D><I><Q><A><Q><I><D><S><I><V><E><L><V><C><K><T><L><R><G><I><N><S><R><H><P><S><L><A><F><K><A><G><E><S><S><M><I><M><E><I><E><L><Q><S><Q><V><L><D><A><M><N><Y><V><L><Y><D><Q><L><K><F><K><G><N><R><M><D><Y><Y><N><A><L><N><L><Y><M><H><Q><V><L><I><R><R><T><G><I><P><I><S><M><S><L><L><Y><L><T><I><A><R><Q><L><G><V><P><L><E><P><V><N><F><P><S><H><F><L><L><R><W><C><Q><G><A><E><G><A><T><L><D><I><F><D><Y><I><Y><I><D><A><F><G><K><G><K><Q><L><T><V><K><E><C><E><Y><L><I><G><Q><H><V><T><A><A><L><Y><G><V><V><N><V><K><K><V><L><Q><R><M><V><G><N><L><L><S><L><G><K><R><E><G><I><D><Q><S><Y><Q><L><L><R><D><S><L><D><L><Y><L><A><M><Y><P><D><Q><V><Q><L><L><L><L><Q><A><R><L><Y><F><H><L><G><I><W><P><E><K><S><F><C><L><V><L><K><V><L><D><I><L><Q><H><I><Q><T><L><D><P><G><Q><H><G><A><V><G><Y><L><V><Q><H><T><L><E><H><I><E><R><K><K><E><E><V><G><V><E><V><K><L><R><S><D><E><K><H><R><D><V><C><Y><S><I><G><L><I><M><K><H><K><R><Y><G><Y><N><C><V><I><Y><G><W><D><P><T><C><M><M><G><H><E><W><I><R><N><M><N><V><H><S><L><P><H><G><H><H><Q><P><F><Y><N><V><L><V><E><D><G><S><C><R><Y><A><A><Q><E><N><L><E><Y><N><V><E><P><Q><E><I><S><H><P><D><V><G><R><Y><F><S><E><F><T><G><T><H><Y><I><P><N><A><E><L><E><I><R><Y><P><E><D><L><E><F><V><Y><E><T><V><Q><N><I><Y><S><A><K><K><E><N><I><D><E>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
O94952
P14091
CATE_HUMAN
Cathepsin E form II
Homo
<M><K><T><L><L><L><L><L><L><V><L><L><E><L><G><E><A><Q><G><S><L><H><R><V><P><L><R><R><H><P><S><L><K><K><K><L><R><A><R><S><Q><L><S><E><F><W><K><S><H><N><L><D><M><I><Q><F><T><E><S><C><S><M><D><Q><S><A><K><E><P><L><I><N><Y><L><D><M><E><Y><F><G><T><I><S><I><G><S><P><P><Q><N><F><T><V><I><F><D><T><G><S><S><N><L><W><V><P><S><V><Y><C><T><S><P><A><C><K><T><H><S><R><F><Q><P><S><Q><S><S><T><Y><S><Q><P><G><Q><S><F><S><I><Q><Y><G><T><G><S><L><S><G><I><I><G><A><D><Q><V><S><V><E><G><L><T><V><V><G><Q><Q><F><G><E><S><V><T><E><P><G><Q><T><F><V><D><A><E><F><D><G><I><L><G><L><G><Y><P><S><L><A><V><G><G><V><T><P><V><F><D><N><M><M><A><Q><N><L><V><D><L><P><M><F><S><V><Y><M><S><S><N><P><E><G><G><A><G><S><E><L><I><F><G><G><Y><D><H><S><H><F><S><G><S><L><N><W><V><P><V><T><K><Q><A><Y><W><Q><I><A><L><D><N><I><Q><V><G><G><T><V><M><F><C><S><E><G><C><Q><A><I><V><D><T><G><T><S><L><I><T><G><P><S><D><K><I><K><Q><L><Q><N><A><I><G><A><A><P><V><D><G><E><Y><A><V><E><C><A><N><L><N><V><M><P><D><V><T><F><T><I><N><G><V><P><Y><T><L><S><P><T><A><Y><T><L><L><D><F><V><D><G><M><Q><F><C><S><S><G><F><Q><G><L><D><I><H><P><P><A><G><P><L><W><I><L><G><D><V><F><I><R><Q><F><Y><S><V><F><D><R><G><N><N><R><V><G><L><A><P><A><V><P>
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.<BOP>
P14091
P53990
IST1_HUMAN
Putative MAPK-activating protein PM28
Homo
<M><L><G><S><G><F><K><A><E><R><L><R><V><N><L><R><L><V><I><N><R><L><K><L><L><E><K><K><K><T><E><L><A><Q><K><A><R><K><E><I><A><D><Y><L><A><A><G><K><D><E><R><A><R><I><R><V><E><H><I><I><R><E><D><Y><L><V><E><A><M><E><I><L><E><L><Y><C><D><L><L><L><A><R><F><G><L><I><Q><S><M><K><E><L><D><S><G><L><A><E><S><V><S><T><L><I><W><A><A><P><R><L><Q><S><E><V><A><E><L><K><I><V><A><D><Q><L><C><A><K><Y><S><K><E><Y><G><K><L><C><R><T><N><Q><I><G><T><V><N><D><R><L><M><H><K><L><S><V><E><A><P><P><K><I><L><V><E><R><Y><L><I><E><I><A><K><N><Y><N><V><P><Y><E><P><D><S><V><V><M><A><E><A><P><P><G><V><E><T><D><L><I><D><V><G><F><T><D><D><V><K><K><G><G><P><G><R><G><G><S><G><G><F><T><A><P><V><G><G><P><D><G><T><V><P><M><P><M><P><M><P><M><P><S><A><N><T><P><F><S><Y><P><L><P><K><G><P><S><D><F><N><G><L><P><M><G><T><Y><Q><A><F><P><N><I><H><P><P><Q><I><P><A><T><P><P><S><Y><E><S><V><D><D><I><N><A><D><K><N><I><S><S><A><Q><I><V><G><P><G><P><K><P><E><A><S><A><K><L><P><S><R><P><A><D><N><Y><D><N><F><V><L><P><E><L><P><S><V><P><D><T><L><P><T><A><S><A><G><A><S><T><S><A><S><E><D><I><D><F><D><D><L><S><R><R><F><E><E><L><K><K><K><T>
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation . Is required for efficient abscission during cytokinesis . Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells . During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing . Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 . Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST .<BOP>
P53990
P0C645
OR4E1_HUMAN
Olfactory receptor OR14-43
Homo
<M><E><E><A><I><L><L><N><Q><T><S><L><V><T><Y><F><R><L><R><G><L><S><V><N><H><K><A><R><I><A><M><F><S><M><F><L><I><F><Y><V><L><T><L><I><G><N><V><L><I><V><I><T><I><I><Y><D><H><R><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><I><D><V><C><H><S><T><V><T><V><P><K><M><L><R><D><V><W><S><E><E><K><L><I><S><F><D><A><C><V><T><Q><M><F><F><L><H><L><F><A><C><T><E><I><F><L><L><T><V><M><A><Y><D><R><Y><V><A><I><C><K><P><L><Q><Y><M><I><V><M><N><W><K><V><C><V><L><L><A><V><A><L><W><T><G><G><T><I><H><S><I><A><L><T><S><L><T><I><K><L><P><Y><C><G><P><D><E><I><D><N><F><F><C><D><V><P><Q><V><I><K><L><A><C><I><D><T><H><V><I><E><I><L><I><V><S><N><S><G><L><I><S><V><V><C><F><V><V><L><V><V><S><Y><A><V><I><L><V><S><L><R><Q><Q><I><S><K><G><K><R><K><A><L><S><T><C><A><A><H><L><T><V><V><T><L><F><L><G><H><C><I><F><I><Y><S><R><P><S><T><S><L><P><E><D><K><V><V><S><V><F><F><T><A><V><T><P><L><L><N><P><I><I><Y><T><L><R><N><E><E><M><K><S><A><L><N><K><L><V><G><R><K><E><R><K><E><E><K>
Odorant receptor.<BOP>
P0C645
O75712
CXB3_HUMAN
Connexin-31
Homo
<M><D><W><K><T><L><Q><A><L><L><S><G><V><N><K><Y><S><T><A><F><G><R><I><W><L><S><V><V><F><V><F><R><V><L><V><Y><V><V><A><A><E><R><V><W><G><D><E><Q><K><D><F><D><C><N><T><K><Q><P><G><C><T><N><V><C><Y><D><N><Y><F><P><I><S><N><I><R><L><W><A><L><Q><L><I><F><V><T><C><P><S><L><L><V><I><L><H><V><A><Y><R><E><E><R><E><R><R><H><R><Q><K><H><G><D><Q><C><A><K><L><Y><D><N><A><G><K><K><H><G><G><L><W><W><T><Y><L><F><S><L><I><F><K><L><I><I><E><F><L><F><L><Y><L><L><H><T><L><W><H><G><F><N><M><P><R><L><V><Q><C><A><N><V><A><P><C><P><N><I><V><D><C><Y><I><A><R><P><T><E><K><K><I><F><T><Y><F><M><V><G><A><S><A><V><C><I><V><L><T><I><C><E><L><C><Y><L><I><C><H><R><V><L><R><G><L><H><K><D><K><P><R><G><G><C><S><P><S><S><S><A><S><R><A><S><T><C><R><C><H><H><K><L><V><E><A><G><E><V><D><P><D><P><G><N><N><K><L><Q><A><S><A><P><N><L><T><P><I>
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP>
O75712
Q9Y471
CMAH_HUMAN
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene
Homo
<M><D><E><N><N><G><L><L><L><L><E><L><N><P><P><N><P><W><D><L><Q><P><R><S><P><E><E><L><A><F><G><E><V><Q><I><T><Y><L><T><H><A><C><M><D><L><K><L><G><D><K><R><M><V><F><D><P><W><L><I><G><P><A><F><A><R><G><W><W><L><L><H><E><P><P><S><D><W><L><E><R><L><C><Q><A><D><L><I><Y><I><S><H><L><H><S><D><H><L><S><Y><P><T><L><K><K><L><A><G><R><R><P><D><I><P><I><Y><V><G><N><T><E><R><P><V><F><W><N><L><N><Q><S><G><V><Q><L><T><N><I><N><V><V><P><F><G><I><W><Q><Q><V><D><K><N><L><R><F><M><I><L><M><D><G><V><H><P><E><M><D><T><C><I><I><V><E><Y><K><G><H><K><I><L><N><I><V><D><C><T><R><P><N><G><G><R><L><P><M><K><V><A><L><M><M><S><D><F><A><G><G><A><S><G><F><P><M><T><F><S><G><G><K><F><T><E><E><W><K><A><Q><F><I><K><T><E><R><K><K><L><L><N><Y><K><A><R><L><V><K><N><L><Q><P><R><I><Y><C><P><F><A><G><Y><F><V><E><S><H><P><S><D><K><Y><I><K><E><T><N><T><K><N><D><P><N><E><L><N><N><L><I><K><K><N><S><D><V><I><T><W><T><P><R><P><G><A><T><L><D><L><G><R><M><L><K><D><R><T><D><S><K><G><I><I><E><P><P><E><G><T><K><I><Y><K><D><S><W><D><F><E><P><Y><L><E><I><L><N><A><A><L><G><D><E><I><F><L><H><S><S><W><I><K><E><Y><F><T><W><A><G><F><K><D><Y><N><L><V><V><R><M><I><E><T><D><E><D><F><N><P><F><P><G><G><Y><D><Y><L><V><D><F><L><D><L><S><F><P><K><E><R><P><Q><R><E><H><P><Y><E><E><I><H><S><R><V><D><V><I><R><H><V><V><K><N><G><L><L><W><D><E><L><Y><I><G><F><Q><T><R><L><Q><R><D><P><D><I><Y><H><H><L><F><W><N><H><F><Q><I><K><L><P><L><T><P><P><N><W><K><S><F><L><M><C><C><E><Q><N><G><P><V><I><L><Q><F><S><T><E><R><T><N><E><P><N><R><N><K><F><S><V><E><N><K><A>
Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates . However, it may play a role in Wnt signaling .<BOP>
Q9Y471
Q8NET1
D108B_HUMAN
Defensin, beta 108B
Homo
<M><R><I><A><V><L><L><F><A><I><F><F><F><M><S><Q><V><L><P><A><R><G><K><F><K><E><I><C><E><R><P><N><G><S><C><R><D><F><C><L><E><T><E><I><H><V><G><R><C><L><N><S><Q><P><C><C><L><P><L><G><H><Q><P><R><I><E><S><T><T><P><K><K><D>
Has antibacterial activity.<BOP>
Q8NET1
Q9H1K1
ISCU_HUMAN
NifU-like protein
Homo
<M><A><A><A><G><A><F><R><L><R><R><A><A><S><A><L><L><L><R><S><P><R><L><P><A><R><E><L><S><A><P><A><R><L><Y><H><K><K><V><V><D><H><Y><E><N><P><R><N><V><G><S><L><D><K><T><S><K><N><V><G><T><G><L><V><G><A><P><A><C><G><D><V><M><K><L><Q><I><Q><V><D><E><K><G><K><I><V><D><A><R><F><K><T><F><G><C><G><S><A><I><A><S><S><S><L><A><T><E><W><V><K><G><K><T><V><E><E><A><L><T><I><K><N><T><D><I><A><K><E><L><C><L><P><P><V><K><L><H><C><S><M><L><A><E><D><A><I><K><A><A><L><A><D><Y><K><L><K><Q><E><P><K><K><G><E><A><E><K><K>
Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm.<BOP>
Q9H1K1
Q9NQB0
TF7L2_HUMAN
T-cell-specific transcription factor 4
Homo
<M><P><Q><L><N><G><G><G><G><D><D><L><G><A><N><D><E><L><I><S><F><K><D><E><G><E><Q><E><E><K><S><S><E><N><S><S><A><E><R><D><L><A><D><V><K><S><S><L><V><N><E><S><E><T><N><Q><N><S><S><S><D><S><E><A><E><R><R><P><P><P><R><S><E><S><F><R><D><K><S><R><E><S><L><E><E><A><A><K><R><Q><D><G><G><L><F><K><G><P><P><Y><P><G><Y><P><F><I><M><I><P><D><L><T><S><P><Y><L><P><N><G><S><L><S><P><T><A><R><T><L><H><F><Q><S><G><S><T><H><Y><S><A><Y><K><T><I><E><H><Q><I><A><V><Q><Y><L><Q><M><K><W><P><L><L><D><V><Q><A><G><S><L><Q><S><R><Q><A><L><K><D><A><R><S><P><S><P><A><H><I><V><S><N><K><V><P><V><V><Q><H><P><H><H><V><H><P><L><T><P><L><I><T><Y><S><N><E><H><F><T><P><G><N><P><P><P><H><L><P><A><D><V><D><P><K><T><G><I><P><R><P><P><H><P><P><D><I><S><P><Y><Y><P><L><S><P><G><T><V><G><Q><I><P><H><P><L><G><W><L><V><P><Q><Q><G><Q><P><V><Y><P><I><T><T><G><G><F><R><H><P><Y><P><T><A><L><T><V><N><A><S><M><S><R><F><P><P><H><M><V><P><P><H><H><T><L><H><T><T><G><I><P><H><P><A><I><V><T><P><T><V><K><Q><E><S><S><Q><S><D><V><G><S><L><H><S><S><K><H><Q><D><S><K><K><E><E><E><K><K><K><P><H><I><K><K><P><L><N><A><F><M><L><Y><M><K><E><M><R><A><K><V><V><A><E><C><T><L><K><E><S><A><A><I><N><Q><I><L><G><R><R><W><H><A><L><S><R><E><E><Q><A><K><Y><Y><E><L><A><R><K><E><R><Q><L><H><M><Q><L><Y><P><G><W><S><A><R><D><N><Y><G><K><K><K><K><R><K><R><D><K><Q><P><G><E><T><N><E><H><S><E><C><F><L><N><P><C><L><S><L><P><P><I><T><D><L><S><A><P><K><K><C><R><A><R><F><G><L><D><Q><Q><N><N><W><C><G><P><C><R><R><K><K><K><C><V><R><Y><I><Q><G><E><G><S><C><L><S><P><P><S><S><D><G><S><L><L><D><S><P><P><P><S><P><N><L><L><G><S><P><P><R><D><A><K><S><Q><T><E><Q><T><Q><P><L><S><L><S><L><K><P><D><P><L><A><H><L><S><M><M><P><P><P><P><A><L><L><L><A><E><A><T><H><K><A><S><A><L><C><P><N><G><A><L><D><L><P><P><A><A><L><Q><P><A><A><P><S><S><S><I><A><Q><P><S><T><S><S><L><H><S><H><S><S><L><A><G><T><Q><P><Q><P><L><S><L><V><T><K><S><L><E>
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.<BOP>
Q9NQB0
Q96BF6
NACC2_HUMAN
Repressor with BTB domain and BEN domain
Homo
<M><S><Q><M><L><H><I><E><I><P><N><F><G><N><T><V><L><G><C><L><N><E><Q><R><L><L><G><L><Y><C><D><V><S><I><V><V><K><G><Q><A><F><K><A><H><R><A><V><L><A><A><S><S><L><Y><F><R><D><L><F><S><G><N><S><K><S><A><F><E><L><P><G><S><V><P><P><A><C><F><Q><Q><I><L><S><F><C><Y><T><G><R><L><T><M><T><A><S><E><Q><L><V><V><M><Y><T><A><G><F><L><Q><I><Q><H><I><V><E><R><G><T><D><L><M><F><K><V><S><S><P><H><C><D><S><Q><T><A><V><I><E><D><A><G><S><E><P><Q><S><P><C><N><Q><L><Q><P><A><A><A><A><A><A><P><Y><V><V><S><P><S><V><P><I><P><L><L><T><R><V><K><H><E><A><M><E><L><P><P><A><G><P><G><L><A><P><K><R><P><L><E><T><G><P><R><D><G><V><A><V><A><A><G><A><A><V><A><A><G><T><A><P><L><K><L><P><R><V><S><Y><Y><G><V><P><S><L><A><T><L><I><P><G><I><Q><Q><M><P><Y><P><Q><G><E><R><T><S><P><G><A><S><S><L><P><T><T><D><S><P><T><S><Y><H><N><E><E><D><E><E><D><D><E><A><Y><D><T><M><V><E><E><Q><Y><G><Q><M><Y><I><K><A><S><G><S><Y><A><V><Q><E><K><P><E><P><V><P><L><E><S><R><S><C><V><L><I><R><R><D><L><V><A><L><P><A><S><L><I><S><Q><I><G><Y><R><C><H><P><K><L><Y><S><E><G><D><P><G><E><K><L><E><L><V><A><G><S><G><V><Y><I><T><R><G><Q><L><M><N><C><H><L><C><A><G><V><K><H><K><V><L><L><R><R><L><L><A><T><F><F><D><R><N><T><L><A><N><S><C><G><T><G><I><R><S><S><T><S><D><P><S><R><K><P><L><D><S><R><V><L><N><A><V><K><L><Y><C><Q><N><F><A><P><S><F><K><E><S><E><M><N><V><I><A><A><D><M><C><T><N><A><R><R><V><R><K><R><W><L><P><K><I><K><S><M><L><P><E><G><V><E><M><Y><R><T><V><M><G><S><A><A><A><S><V><P><L><D><P><E><F><P><P><A><A><A><Q><V><F><E><Q><R><I><Y><A><E><R><R><G><D><A><A><T><I><V><A><L><R><T><D><A><V><N><V><D><L><S><A><A><A><N><P><A><F><D><A><G><E><E><V><D><G><A><G><S><V><I><Q><E><V><A><A><P><E><P><L><P><A><D><G><Q><S><P><P><Q><P><F><E><Q><G><G><G><G><P><S><R><P><Q><T><P><A><A><A><A><R><R><P><E><G><T><Y><A><G><T><L>
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.<BOP>
Q96BF6
Q9NXK8
FXL12_HUMAN
F-box protein FBL12
Homo
<M><A><T><L><V><E><L><P><D><S><V><L><L><E><I><F><S><Y><L><P><V><R><D><R><I><R><I><S><R><V><C><H><R><W><K><R><L><V><D><D><R><W><L><W><R><H><V><D><L><T><L><Y><T><M><R><P><K><V><M><W><H><L><L><R><R><Y><M><A><S><R><L><H><S><L><R><M><G><G><Y><L><F><S><G><S><Q><A><P><Q><L><S><P><A><L><L><R><A><L><G><Q><K><C><P><N><L><K><R><L><C><L><H><V><A><D><L><S><M><V><P><I><T><S><L><P><S><T><L><R><T><L><E><L><H><S><C><E><I><S><M><A><W><L><H><K><Q><Q><D><P><T><V><L><P><L><L><E><C><I><V><L><D><R><V><P><A><F><R><D><E><H><L><Q><G><L><T><R><F><R><A><L><R><S><L><V><L><G><G><T><Y><R><V><T><E><T><G><L><D><A><G><L><Q><E><L><S><Y><L><Q><R><L><E><V><L><G><C><T><L><S><A><D><S><T><L><L><A><I><S><R><H><L><R><D><V><R><K><I><R><L><T><V><R><G><L><S><A><P><G><L><A><V><L><E><G><M><P><A><L><E><S><L><C><L><Q><G><P><L><V><T><P><E><M><P><S><P><T><E><I><L><S><S><C><L><T><M><P><K><L><R><V><L><E><L><Q><G><L><G><W><E><G><Q><E><A><E><K><I><L><C><K><G><L><P><H><C><M><V><I><V><R><A><C><P><K><E><S><M><D><W><W><M>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.<BOP>
Q9NXK8
Q8TDN2
KCNV2_HUMAN
Voltage-gated potassium channel subunit Kv8.2
Homo
<M><L><K><Q><S><E><R><R><R><S><W><S><Y><R><P><W><N><T><T><E><N><E><G><S><Q><H><R><R><S><I><C><S><L><G><A><R><S><G><S><Q><A><S><I><H><G><W><T><E><G><N><Y><N><Y><Y><I><E><E><D><E><D><G><E><E><E><D><Q><W><K><D><D><L><A><E><E><D><Q><Q><A><G><E><V><T><T><A><K><P><E><G><P><S><D><P><P><A><L><L><S><T><L><N><V><N><V><G><G><H><S><Y><Q><L><D><Y><C><E><L><A><G><F><P><K><T><R><L><G><R><L><A><T><S><T><S><R><S><R><Q><L><S><L><C><D><D><Y><E><E><Q><T><D><E><Y><F><F><D><R><D><P><A><V><F><Q><L><V><Y><N><F><Y><L><S><G><V><L><L><V><L><D><G><L><C><P><R><R><F><L><E><E><L><G><Y><W><G><V><R><L><K><Y><T><P><R><C><C><R><I><C><F><E><E><R><R><D><E><L><S><E><R><L><K><I><Q><H><E><L><R><A><Q><A><Q><V><E><E><A><E><E><L><F><R><D><M><R><F><Y><G><P><Q><R><R><R><L><W><N><L><M><E><K><P><F><S><S><V><A><A><K><A><I><G><V><A><S><S><T><F><V><L><V><S><V><V><A><L><A><L><N><T><V><E><E><M><Q><Q><H><S><G><Q><G><E><G><G><P><D><L><R><P><I><L><E><H><V><E><M><L><C><M><G><F><F><T><L><E><Y><L><L><R><L><A><S><T><P><D><L><R><R><F><A><R><S><A><L><N><L><V><D><L><V><A><I><L><P><L><Y><L><Q><L><L><L><E><C><F><T><G><E><G><H><Q><R><G><Q><T><V><G><S><V><G><K><V><G><Q><V><L><R><V><M><R><L><M><R><I><F><R><I><L><K><L><A><R><H><S><T><G><L><R><A><F><G><F><T><L><R><Q><C><Y><Q><Q><V><G><C><L><L><L><F><I><A><M><G><I><F><T><F><S><A><A><V><Y><S><V><E><H><D><V><P><S><T><N><F><T><T><I><P><H><S><W><W><W><A><A><V><S><I><S><T><V><G><Y><G><D><M><Y><P><E><T><H><L><G><R><F><F><A><F><L><C><I><A><F><G><I><I><L><N><G><M><P><I><S><I><L><Y><N><K><F><S><D><Y><Y><S><K><L><K><A><Y><E><Y><T><T><I><R><R><E><R><G><E><V><N><F><M><Q><R><A><R><K><K><I><A><E><C><L><L><G><S><N><P><Q><L><T><P><R><Q><E><N>
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.<BOP>
Q8TDN2
Q96RP9
EFGM_HUMAN
Elongation factor G1
Homo
<M><R><L><L><G><A><A><A><V><A><A><L><G><R><G><R><A><P><A><S><L><G><W><Q><R><K><Q><V><N><W><K><A><C><R><W><S><S><S><G><V><I><P><N><E><K><I><R><N><I><G><I><S><A><H><I><D><S><G><K><T><T><L><T><E><R><V><L><Y><Y><T><G><R><I><A><K><M><H><E><V><K><G><K><D><G><V><G><A><V><M><D><S><M><E><L><E><R><Q><R><G><I><T><I><Q><S><A><A><T><Y><T><M><W><K><D><V><N><I><N><I><I><D><T><P><G><H><V><D><F><T><I><E><V><E><R><A><L><R><V><L><D><G><A><V><L><V><L><C><A><V><G><G><V><Q><C><Q><T><M><T><V><N><R><Q><M><K><R><Y><N><V><P><F><L><T><F><I><N><K><L><D><R><M><G><S><N><P><A><R><A><L><Q><Q><M><R><S><K><L><N><H><N><A><A><F><M><Q><I><P><M><G><L><E><G><N><F><K><G><I><V><D><L><I><E><E><R><A><I><Y><F><D><G><D><F><G><Q><I><V><R><Y><G><E><I><P><A><E><L><R><A><A><A><T><D><H><R><Q><E><L><I><E><C><V><A><N><S><D><E><Q><L><G><E><M><F><L><E><E><K><I><P><S><I><S><D><L><K><L><A><I><R><R><A><T><L><K><R><S><F><T><P><V><F><L><G><S><A><L><K><N><K><G><V><Q><P><L><L><D><A><V><L><E><Y><L><P><N><P><S><E><V><Q><N><Y><A><I><L><N><K><E><D><D><S><K><E><K><T><K><I><L><M><N><S><S><R><D><N><S><H><P><F><V><G><L><A><F><K><L><E><V><G><R><F><G><Q><L><T><Y><V><R><S><Y><Q><G><E><L><K><K><G><D><T><I><Y><N><T><R><T><R><K><K><V><R><L><Q><R><L><A><R><M><H><A><D><M><M><E><D><V><E><E><V><Y><A><G><D><I><C><A><L><F><G><I><D><C><A><S><G><D><T><F><T><D><K><A><N><S><G><L><S><M><E><S><I><H><V><P><D><P><V><I><S><I><A><M><K><P><S><N><K><N><D><L><E><K><F><S><K><G><I><G><R><F><T><R><E><D><P><T><F><K><V><Y><F><D><T><E><N><K><E><T><V><I><S><G><M><G><E><L><H><L><E><I><Y><A><Q><R><L><E><R><E><Y><G><C><P><C><I><T><G><K><P><K><V><A><F><R><E><T><I><T><A><P><V><P><F><D><F><T><H><K><K><Q><S><G><G><A><G><Q><Y><G><K><V><I><G><V><L><E><P><L><D><P><E><D><Y><T><K><L><E><F><S><D><E><T><F><G><S><N><I><P><K><Q><F><V><P><A><V><E><K><G><F><L><D><A><C><E><K><G><P><L><S><G><H><K><L><S><G><L><R><F><V><L><Q><D><G><A><H><H><M><V><D><S><N><E><I><S><F><I><R><A><G><E><G><A><L><K><Q><A><L><A><N><A><T><L><C><I><L><E><P><I><M><A><V><E><V><V><A><P><N><E><F><Q><G><Q><V><I><A><G><I><N><R><R><H><G><V><I><T><G><Q><D><G><V><E><D><Y><F><T><L><Y><A><D><V><P><L><N><D><M><F><G><Y><S><T><E><L><R><S><C><T><E><G><K><G><E><Y><T><M><E><Y><S><R><Y><Q><P><C><L><P><S><T><Q><E><D><V><I><N><K><Y><L><E><A><T><G><Q><L><P><V><K><K><G><K><A><K><N>
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.<BOP>
Q96RP9
Q14592
ZN460_HUMAN
Zinc finger protein HZF8
Homo
<M><A><A><A><W><M><A><P><A><Q><E><S><V><T><F><E><D><V><A><V><T><F><T><Q><E><E><W><G><Q><L><D><V><T><Q><R><A><L><Y><V><E><V><M><L><E><T><C><G><L><L><V><A><L><G><D><S><T><K><P><E><T><V><E><P><I><P><S><H><L><A><L><P><E><E><V><S><L><Q><E><Q><L><A><Q><G><V><P><R><Y><S><Y><L><G><Q><A><M><D><Q><D><G><P><S><E><M><Q><E><Y><F><L><R><P><G><T><D><P><Q><S><E><K><L><H><G><K><M><S><L><E><H><E><G><L><A><T><A><D><G><I><C><S><M><M><I><Q><N><Q><V><S><P><E><D><A><L><Y><G><F><D><S><Y><G><P><V><T><D><S><L><I><H><E><G><E><N><S><Y><K><F><E><E><M><F><N><E><N><C><F><L><V><Q><H><E><Q><I><L><P><R><V><K><P><Y><D><C><P><E><C><G><K><A><F><G><K><S><K><H><L><L><Q><H><H><I><I><H><T><G><E><K><P><Y><K><C><L><E><C><G><K><D><F><N><R><R><S><H><L><T><R><H><Q><R><T><H><N><G><D><K><P><F><V><C><S><E><C><G><R><T><F><N><R><G><S><H><L><T><R><H><Q><R><V><H><S><G><E><K><P><F><V><C><N><E><C><G><K><A><F><T><Y><R><S><N><F><V><L><H><N><K><S><H><N><E><K><K><P><F><A><C><S><E><C><G><K><G><F><Y><E><S><T><A><L><I><Q><H><F><I><I><H><T><G><E><R><P><F><K><C><L><E><C><G><K><A><F><N><C><R><S><H><L><K><Q><H><E><R><I><H><T><G><E><K><P><F><V><C><S><Q><C><G><K><A><F><T><H><Y><S><T><Y><V><L><H><E><R><A><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><S><I><R><K><D><L><I><R><H><F><N><I><H><T><G><E><K><P><Y><E><C><L><Q><C><G><K><A><F><T><R><M><S><G><L><T><R><H><Q><W><I><H><T><G><E><K><P><Y><V><C><I><Q><C><G><K><A><F><C><R><T><T><N><L><I><R><H><F><S><I><H><T><G><E><K><P><Y><E><C><V><E><C><G><K><A><F><N><R><R><S><P><L><T><R><H><Q><R><I><H><T><A><E><K><S><H><E><P><I><Q><S><G><N><V><S><C><E><S><T><D><L><I><Q><H><S><I><I><H><T><E><S><S><P><V><S><A><V><N><M><E><T><P><S><I><A><A><H><S><S><S><L><D><I><N><G><F><I><V><E><E><T><L><P><L>
May be involved in transcriptional regulation.<BOP>
Q14592
Q9Y2T3
GUAD_HUMAN
p51-nedasin
Homo
<M><C><A><A><Q><M><P><P><L><A><H><I><F><R><G><T><F><V><H><S><T><W><T><C><P><M><E><V><L><R><D><H><L><L><G><V><S><D><S><G><K><I><V><F><L><E><E><A><S><Q><Q><E><K><L><A><K><E><W><C><F><K><P><C><E><I><R><E><L><S><H><H><E><F><F><M><P><G><L><V><D><T><H><I><H><A><S><Q><Y><S><F><A><G><S><S><I><D><L><P><L><L><E><W><L><T><K><Y><T><F><P><A><E><H><R><F><Q><N><I><D><F><A><E><E><V><Y><T><R><V><V><R><R><T><L><K><N><G><T><T><T><A><C><Y><F><A><T><I><H><T><D><S><S><L><L><L><A><D><I><T><D><K><F><G><Q><R><A><F><V><G><K><V><C><M><D><L><N><D><T><F><P><E><Y><K><E><T><T><E><E><S><I><K><E><T><E><R><F><V><S><E><M><L><Q><K><N><Y><S><R><V><K><P><I><V><T><P><R><F><S><L><S><C><S><E><T><L><M><G><E><L><G><N><I><A><K><T><R><D><L><H><I><Q><S><H><I><S><E><N><R><D><E><V><E><A><V><K><N><L><Y><P><S><Y><K><N><Y><T><S><V><Y><D><K><N><N><L><L><T><N><K><T><V><M><A><H><G><C><Y><L><S><A><E><E><L><N><V><F><H><E><R><G><A><S><I><A><H><C><P><N><S><N><L><S><L><S><S><G><F><L><N><V><L><E><V><L><K><H><E><V><K><I><G><L><G><T><D><V><A><G><G><Y><S><Y><S><M><L><D><A><I><R><R><A><V><M><V><S><N><I><L><L><I><N><K><V><N><E><K><S><L><T><L><K><E><V><F><R><L><A><T><L><G><G><S><Q><A><L><G><L><D><G><E><I><G><N><F><E><V><G><K><E><F><D><A><I><L><I><N><P><K><A><S><D><S><P><I><D><L><F><Y><G><D><F><F><G><D><I><S><E><A><V><I><Q><K><F><L><Y><L><G><D><D><R><N><I><E><E><V><Y><V><G><G><K><Q><V><V><P><F><S><S><S><V>
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.<BOP>
Q9Y2T3
Q96LX8
ZN597_HUMAN
Zinc finger protein 597
Homo
<M><A><S><M><P><P><T><P><E><A><Q><G><P><I><L><F><E><D><L><A><V><Y><F><S><Q><E><E><C><V><T><L><H><P><A><Q><R><S><L><S><K><D><G><T><K><E><S><L><E><D><A><A><L><M><G><E><E><G><K><P><E><I><N><Q><Q><L><S><L><E><S><M><E><L><D><E><L><A><L><E><K><Y><P><I><A><A><P><L><V><P><Y><P><E><K><S><S><E><D><G><V><G><N><P><E><A><K><I><L><S><G><T><P><T><Y><K><R><R><V><I><S><L><L><V><T><I><E><N><H><T><P><L><V><E><L><S><E><Y><L><G><T><N><T><L><S><E><I><L><D><S><P><W><E><G><A><K><N><V><Y><K><C><P><E><C><D><Q><N><F><S><D><H><S><Y><L><V><L><H><Q><K><I><H><S><G><E><K><K><H><K><C><G><D><C><G><K><I><F><N><H><R><A><N><L><R><T><H><R><R><I><H><T><G><E><K><P><Y><K><C><A><K><C><S><A><S><F><R><Q><H><S><H><L><S><R><H><M><N><S><H><V><K><E><K><P><Y><T><C><S><I><C><G><R><G><F><M><W><L><P><G><L><A><Q><H><Q><K><S><H><S><A><E><N><T><Y><E><S><T><N><C><D><K><H><F><N><E><K><P><N><L><A><L><P><E><E><T><F><V><S><G><P><Q><Y><Q><H><T><K><C><M><K><S><F><R><Q><S><L><Y><P><A><L><S><E><K><S><H><D><E><D><S><E><R><C><S><D><D><G><D><N><F><F><S><F><S><K><F><K><P><L><Q><C><P><D><C><D><M><T><F><P><C><F><S><E><L><I><S><H><Q><N><I><H><T><E><E><R><P><H><K><C><K><T><C><E><E><S><F><A><L><D><S><E><L><A><C><H><Q><K><S><H><M><L><A><E><P><F><K><C><T><V><C><G><K><T><F><K><S><N><L><H><L><I><T><H><K><R><T><H><I><K><N><T><T>
May be involved in transcriptional regulation.<BOP>
Q96LX8
P01589
IL2RA_HUMAN
p55
Homo
<M><D><S><Y><L><L><M><W><G><L><L><T><F><I><M><V><P><G><C><Q><A><E><L><C><D><D><D><P><P><E><I><P><H><A><T><F><K><A><M><A><Y><K><E><G><T><M><L><N><C><E><C><K><R><G><F><R><R><I><K><S><G><S><L><Y><M><L><C><T><G><N><S><S><H><S><S><W><D><N><Q><C><Q><C><T><S><S><A><T><R><N><T><T><K><Q><V><T><P><Q><P><E><E><Q><K><E><R><K><T><T><E><M><Q><S><P><M><Q><P><V><D><Q><A><S><L><P><G><H><C><R><E><P><P><P><W><E><N><E><A><T><E><R><I><Y><H><F><V><V><G><Q><M><V><Y><Y><Q><C><V><Q><G><Y><R><A><L><H><R><G><P><A><E><S><V><C><K><M><T><H><G><K><T><R><W><T><Q><P><Q><L><I><C><T><G><E><M><E><T><S><Q><F><P><G><E><E><K><P><Q><A><S><P><E><G><R><P><E><S><E><T><S><C><L><V><T><T><T><D><F><Q><I><Q><T><E><M><A><A><T><M><E><T><S><I><F><T><T><E><Y><Q><V><A><V><A><G><C><V><F><L><L><I><S><V><L><L><L><S><G><L><T><W><Q><R><R><Q><R><K><S><R><R><T><I>
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.<BOP>
P01589
Q9UBM7
DHCR7_HUMAN
Sterol reductase SR-2
Homo
<M><A><A><K><S><Q><P><N><I><P><K><A><K><S><L><D><G><V><T><N><D><R><T><A><S><Q><G><Q><W><G><R><A><W><E><V><D><W><F><S><L><A><S><V><I><F><L><L><L><F><A><P><F><I><V><Y><Y><F><I><M><A><C><D><Q><Y><S><C><A><L><T><G><P><V><V><D><I><V><T><G><H><A><R><L><S><D><I><W><A><K><T><P><P><I><T><R><K><A><A><Q><L><Y><T><L><W><V><T><F><Q><V><L><L><Y><T><S><L><P><D><F><C><H><K><F><L><P><G><Y><V><G><G><I><Q><E><G><A><V><T><P><A><G><V><V><N><K><Y><Q><I><N><G><L><Q><A><W><L><L><T><H><L><L><W><F><A><N><A><H><L><L><S><W><F><S><P><T><I><I><F><D><N><W><I><P><L><L><W><C><A><N><I><L><G><Y><A><V><S><T><F><A><M><V><K><G><Y><F><F><P><T><S><A><R><D><C><K><F><T><G><N><F><F><Y><N><Y><M><M><G><I><E><F><N><P><R><I><G><K><W><F><D><F><K><L><F><F><N><G><R><P><G><I><V><A><W><T><L><I><N><L><S><F><A><A><K><Q><R><E><L><H><S><H><V><T><N><A><M><V><L><V><N><V><L><Q><A><I><Y><V><I><D><F><F><W><N><E><T><W><Y><L><K><T><I><D><I><C><H><D><H><F><G><W><Y><L><G><W><G><D><C><V><W><L><P><Y><L><Y><T><L><Q><G><L><Y><L><V><Y><H><P><V><Q><L><S><T><P><H><A><V><G><V><L><L><L><G><L><V><G><Y><Y><I><F><R><V><A><N><H><Q><K><D><L><F><R><R><T><D><G><R><C><L><I><W><G><R><K><P><K><V><I><E><C><S><Y><T><S><A><D><G><Q><R><H><H><S><K><L><L><V><S><G><F><W><G><V><A><R><H><F><N><Y><V><G><D><L><M><G><S><L><A><Y><C><L><A><C><G><G><G><H><L><L><P><Y><F><Y><I><I><Y><M><A><I><L><L><T><H><R><C><L><R><D><E><H><R><C><A><S><K><Y><G><R><D><W><E><R><Y><T><A><A><V><P><Y><R><L><L><P><G><I><F>
7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway.<BOP>
Q9UBM7
Q8WUJ1
NEUFC_HUMAN
Cytochrome b5 domain-containing protein 2
Homo
<M><L><R><C><G><G><R><G><L><L><L><G><L><A><V><A><A><A><A><V><M><A><A><R><L><M><G><W><W><G><P><R><A><G><F><R><L><F><I><P><E><E><L><S><R><Y><R><G><G><P><G><D><P><G><L><Y><L><A><L><L><G><R><V><Y><D><V><S><S><G><R><R><H><Y><E><P><G><S><H><Y><S><G><F><A><G><R><D><A><S><R><A><F><V><T><G><D><C><S><E><A><G><L><V><D><D><V><S><D><L><S><A><A><E><M><L><T><L><H><N><W><L><S><F><Y><E><K><N><Y><V><C><V><G><R><V><T><G><R><F><Y><G><E><D><G><L><P><T><P><A><L><T><Q><V><E><A><A><I><T><R><G><L><E><A><N><K><L><Q><L><Q><E><K><Q><T><F><P><P><C><N><A><E><W><S><S><A><R><G><S><R><L><W><C><S><Q><K><S><G><G><V><S><R><D><W><I><G><V><P><R><K><L><Y><K><P><G><A><K><E><P><R><C><V><C><V><R><T><T><G><P><P><S><G><Q><M><P><D><N><P><P><H><R><N><R><G><D><L><D><H><P><N><L><A><E><Y><T><G><C><P><P><L><A><I><T><C><S><F><P><L>
Heme-binding protein which promotes neuronal but not astrocyte differentiation.<BOP>
Q8WUJ1
Q93038
TNR25_HUMAN
Protein WSL-1
Homo
<M><E><Q><R><P><R><G><C><A><A><V><A><A><A><L><L><L><V><L><L><G><A><R><A><Q><G><G><T><R><S><P><R><C><D><C><A><G><D><F><H><K><K><I><G><L><F><C><C><R><G><C><P><A><G><H><Y><L><K><A><P><C><T><E><P><C><G><N><S><T><C><L><V><C><P><Q><D><T><F><L><A><W><E><N><H><H><N><S><E><C><A><R><C><Q><A><C><D><E><Q><A><S><Q><V><A><L><E><N><C><S><A><V><A><D><T><R><C><G><C><K><P><G><W><F><V><E><C><Q><V><S><Q><C><V><S><S><S><P><F><Y><C><Q><P><C><L><D><C><G><A><L><H><R><H><T><R><L><L><C><S><R><R><D><T><D><C><G><T><C><L><P><G><F><Y><E><H><G><D><G><C><V><S><C><P><T><S><T><L><G><S><C><P><E><R><C><A><A><V><C><G><W><R><Q><M><F><W><V><Q><V><L><L><A><G><L><V><V><P><L><L><L><G><A><T><L><T><Y><T><Y><R><H><C><W><P><H><K><P><L><V><T><A><D><E><A><G><M><E><A><L><T><P><P><P><A><T><H><L><S><P><L><D><S><A><H><T><L><L><A><P><P><D><S><S><E><K><I><C><T><V><Q><L><V><G><N><S><W><T><P><G><Y><P><E><T><Q><E><A><L><C><P><Q><V><T><W><S><W><D><Q><L><P><S><R><A><L><G><P><A><A><A><P><T><L><S><P><E><S><P><A><G><S><P><A><M><M><L><Q><P><G><P><Q><L><Y><D><V><M><D><A><V><P><A><R><R><W><K><E><F><V><R><T><L><G><L><R><E><A><E><I><E><A><V><E><V><E><I><G><R><F><R><D><Q><Q><Y><E><M><L><K><R><W><R><Q><Q><Q><P><A><G><L><G><A><V><Y><A><A><L><E><R><M><G><L><D><G><C><V><E><D><L><R><S><R><L><Q><R><G><P>
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.<BOP>
Q93038
Q96FV9
THOC1_HUMAN
hTREX84
Homo
<M><S><P><T><P><P><L><F><S><L><P><E><A><R><T><R><F><T><K><S><T><R><E><A><L><N><N><K><N><I><K><P><L><L><S><T><F><S><Q><V><P><G><S><E><N><E><K><K><C><T><L><D><Q><A><F><R><G><I><L><E><E><E><I><I><N><H><S><S><C><E><N><V><L><A><I><I><S><L><A><I><G><G><V><T><E><G><I><C><T><A><S><T><P><F><V><L><L><G><D><V><L><D><C><L><P><L><D><Q><C><D><T><I><F><T><F><V><E><K><N><V><A><T><W><K><S><N><T><F><Y><S><A><G><K><N><Y><L><L><R><M><C><N><D><L><L><R><R><L><S><K><S><Q><N><T><V><F><C><G><R><I><Q><L><F><L><A><R><L><F><P><L><S><E><K><S><G><L><N><L><Q><S><Q><F><N><L><E><N><V><T><V><F><N><T><N><E><Q><E><S><T><L><G><Q><K><H><T><E><D><R><E><E><G><M><D><V><E><E><G><E><M><G><D><E><E><A><P><T><T><C><S><I><P><I><D><Y><N><L><Y><R><K><F><W><S><L><Q><D><Y><F><R><N><P><V><Q><C><Y><E><K><I><S><W><K><T><F><L><K><Y><S><E><E><V><L><A><V><F><K><S><Y><K><L><D><D><T><Q><A><S><R><K><K><M><E><E><L><K><T><G><G><E><H><V><Y><F><A><K><F><L><T><S><E><K><L><M><D><L><Q><L><S><D><S><N><F><R><R><H><I><L><L><Q><Y><L><I><L><F><Q><Y><L><K><G><Q><V><K><F><K><S><S><N><Y><V><L><T><D><E><Q><S><L><W><I><E><D><T><T><K><S><V><Y><Q><L><L><S><E><N><P><P><D><G><E><R><F><S><K><M><V><E><H><I><L><N><T><E><E><N><W><N><S><W><K><N><E><G><C><P><S><F><V><K><E><R><T><S><D><T><K><P><T><R><I><I><R><K><R><T><A><P><E><D><F><L><G><K><G><P><T><K><K><I><L><M><G><N><E><E><L><T><R><L><W><N><L><C><P><D><N><M><E><A><C><K><S><E><T><R><E><H><M><P><T><L><E><E><F><F><E><E><A><I><E><Q><A><D><P><E><N><M><V><E><N><E><Y><K><A><V><N><N><S><N><Y><G><W><R><A><L><R><L><L><A><R><R><S><P><H><F><F><Q><P><T><N><Q><Q><F><K><S><L><P><E><Y><L><E><N><M><V><I><K><L><A><K><E><L><P><P><P><S><E><E><I><K><T><G><E><D><E><D><E><E><D><N><D><A><L><L><K><E><N><E><S><P><D><V><R><R><D><K><P><V><T><G><E><Q><I><E><V><F><A><N><K><L><G><E><Q><W><K><I><L><A><P><Y><L><E><M><K><D><S><E><I><R><Q><I><E><C><D><S><E><D><M><K><M><R><A><K><Q><L><L><V><A><W><Q><D><Q><E><G><V><H><A><T><P><E><N><L><I><N><A><L><N><K><S><G><L><S><D><L><A><E><S><L><T><N><D><N><E><T><N><S>
Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.<BOP>
Q96FV9
Q6P1L8
RM14_HUMAN
Mitochondrial large ribosomal subunit protein uL14m
Homo
<M><A><F><F><T><G><L><W><G><P><F><T><C><V><S><R><V><L><S><H><H><C><F><S><T><T><G><S><L><S><A><I><Q><K><M><T><R><V><R><V><V><D><N><S><A><L><G><N><S><P><Y><H><R><A><P><R><C><I><H><V><Y><K><K><N><G><V><G><K><V><G><D><Q><I><L><L><A><I><K><G><Q><K><K><K><A><L><I><V><G><H><C><M><P><G><P><R><M><T><P><R><F><D><S><N><N><V><V><L><I><E><D><N><G><N><P><V><G><T><R><I><K><T><P><I><P><T><S><L><R><K><R><E><G><E><Y><S><K><V><L><A><I><A><Q><N><F><V>
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).<BOP>
Q6P1L8
Q9H3U5
MFSD1_HUMAN
Smooth muscle cell-associated protein 4
Homo
<M><E><E><E><D><E><E><A><R><A><L><L><A><G><G><P><D><E><A><D><R><G><A><P><A><A><P><G><A><L><P><A><L><C><D><P><S><R><L><A><H><R><L><L><V><L><L><L><M><C><F><L><G><F><G><S><Y><F><C><Y><D><N><P><A><A><L><Q><T><Q><V><K><R><D><M><Q><V><N><T><T><K><F><M><L><L><Y><A><W><Y><S><W><P><N><V><V><L><C><F><F><G><G><F><L><I><D><R><V><F><G><I><R><W><G><T><I><I><F><S><C><F><V><C><I><G><Q><V><V><F><A><L><G><G><I><F><N><A><F><W><L><M><E><F><G><R><F><V><F><G><I><G><G><E><S><L><A><V><A><Q><N><T><Y><A><V><S><W><F><K><G><K><E><L><N><L><V><F><G><L><Q><L><S><M><A><R><I><G><S><T><V><N><M><N><L><M><G><W><L><Y><S><K><I><E><A><L><L><G><S><A><G><H><T><T><L><G><I><T><L><M><I><G><G><I><T><C><I><L><S><L><I><C><A><L><A><L><A><Y><L><D><Q><R><A><E><R><I><L><H><K><E><Q><G><K><T><G><E><V><I><K><L><T><D><V><K><D><F><S><L><P><L><W><L><I><F><I><I><C><V><C><Y><Y><V><A><V><F><P><F><I><G><L><G><K><V><F><F><T><E><K><F><G><F><S><S><Q><A><A><S><A><I><N><S><V><V><Y><V><I><S><A><P><M><S><P><V><F><G><L><L><V><D><K><T><G><K><N><I><I><W><V><L><C><A><V><A><A><T><L><V><S><H><M><M><L><A><F><T><M><W><N><P><W><I><A><M><C><L><L><G><L><S><Y><S><L><L><A><C><A><L><W><P><M><V><A><F><V><V><P><E><H><Q><L><G><T><A><Y><G><F><M><Q><S><I><Q><N><L><G><L><A><I><I><S><I><I><A><G><M><I><L><D><S><R><G><Y><L><F><L><E><V><F><F><I><A><C><V><S><L><S><L><L><S><V><V><L><L><Y><L><V><N><R><A><Q><G><G><N><L><N><Y><S><A><R><Q><R><E><E><I><K><F><S><H><T><E>
Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.<BOP>
Q9H3U5
Q14568
HS902_HUMAN
Heat shock protein HSP 90-alpha A2 pseudogene
Homo
<M><P><E><E><T><Q><T><Q><D><Q><P><M><E><E><E><E><V><E><T><F><A><F><Q><A><E><I><A><Q><L><M><S><L><I><I><N><T><F><Y><S><N><K><E><I><F><L><R><E><L><I><S><N><S><S><D><A><L><D><K><I><W><Y><E><S><L><T><D><P><S><K><L><D><S><G><K><E><L><H><I><N><L><I><P><N><K><Q><D><Q><T><L><T><I><V><D><T><G><I><G><M><T><K><A><D><L><I><N><N><L><G><T><I><A><K><S><G><T><K><A><F><M><E><A><L><Q><A><G><A><D><I><S><M><I><G><Q><F><G><V><S><F><Y><S><A><Y><L><V><A><E><K><V><T><V><I><T><K><H><N><D><D><E><Q><Y><A><W><E><S><S><A><G><G><S><F><T><V><R><T><D><T><G><E><R><M><G><R><G><T><K><V><I><L><H><L><K><E><D><Q><T><E><Y><L><E><E><Q><R><I><K><E><I><V><K><K><H><S><Q><L><I><G><Y><P><I><T><L><F><V><E><K><E><C><D><K><E><V><S><D><D><E><T><E><E><K><E><D><K><E><E><E><K><E><K><E><E><K><E><S><K><D><K><P><E><I><E><D><V><G><S><D><E><E><E><E><K><K><D><G><D><K><K><K><K><K><T><K><E><K><Y><I><D><Q><E><E><L><N><K><T><K><P><I><W><T><R><N><P><D><D><I><T><N><E><E><Y><G><E><F><C><K><N><L><T><N><D><W><E><D><H><L><A><V><K><H><F><S><V><E><G><Q><L><E><F><R><A><L><L><F><V><P>
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.<BOP>
Q14568
A2RU49
HYKK_HUMAN
Aminoglycoside phosphotransferase domain-containing protein 1
Homo
<M><S><S><G><N><Y><Q><Q><S><E><A><L><S><K><P><T><F><S><E><E><Q><A><S><A><L><V><E><S><V><F><G><L><K><V><S><K><V><R><P><L><P><S><Y><D><D><Q><N><F><H><V><Y><V><S><K><T><K><D><G><P><T><E><Y><V><L><K><I><S><N><T><K><A><S><K><N><P><D><L><I><E><V><Q><N><H><I><I><M><F><L><K><A><A><G><F><P><T><A><S><V><C><H><T><K><G><D><N><T><A><S><L><V><S><V><D><S><G><S><E><I><K><S><Y><L><V><R><L><L><T><Y><L><P><G><R><P><I><A><E><L><P><V><S><P><Q><L><L><Y><E><I><G><K><L><A><A><K><L><D><K><T><L><Q><R><F><H><H><P><K><L><S><S><L><H><R><E><N><F><I><W><N><L><K><N><V><P><L><L><E><K><Y><L><Y><A><L><G><Q><N><R><N><R><E><I><V><E><H><V><I><H><L><F><K><E><E><V><M><T><K><L><S><H><F><R><E><C><I><N><H><G><D><L><N><D><H><N><I><L><I><E><S><S><K><S><A><S><G><N><A><E><Y><Q><V><S><G><I><L><D><F><G><D><M><S><Y><G><Y><Y><V><F><E><V><A><I><T><I><M><Y><M><M><I><E><S><K><S><P><I><Q><V><G><G><H><V><L><A><G><F><E><S><I><T><P><L><T><A><V><E><K><G><A><L><F><L><L><V><C><S><R><F><C><Q><S><L><V><M><A><A><Y><S><C><Q><L><Y><P><E><N><K><D><Y><L><M><V><T><A><K><T><G><W><K><H><L><Q><Q><M><F><D><M><G><Q><K><A><V><E><E><I><W><F><E><T><A><K><S><Y><E><S><G><I><S><M>
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.<BOP>
A2RU49
P62324
BTG1_HUMAN
B-cell translocation gene 1 protein
Homo
<M><H><P><F><Y><T><R><A><A><T><M><I><G><E><I><A><A><A><V><S><F><I><S><K><F><L><R><T><K><G><L><T><S><E><R><Q><L><Q><T><F><S><Q><S><L><Q><E><L><L><A><E><H><Y><K><H><H><W><F><P><E><K><P><C><K><G><S><G><Y><R><C><I><R><I><N><H><K><M><D><P><L><I><G><Q><A><A><Q><R><I><G><L><S><S><Q><E><L><F><R><L><L><P><S><E><L><T><L><W><V><D><P><Y><E><V><S><Y><R><I><G><E><D><G><S><I><C><V><L><Y><E><A><S><P><A><G><G><S><T><Q><N><S><T><N><V><Q><M><V><D><S><R><I><S><C><K><E><E><L><L><L><G><R><T><S><P><S><K><N><Y><N><M><M><T><V><S><G>
Anti-proliferative protein.<BOP>
P62324
P51857
AK1D1_HUMAN
Delta(4)-3-oxosteroid 5-beta-reductase
Homo
<M><D><L><S><A><A><S><H><R><I><P><L><S><D><G><N><S><I><P><I><I><G><L><G><T><Y><S><E><P><K><S><T><P><K><G><A><C><A><T><S><V><K><V><A><I><D><T><G><Y><R><H><I><D><G><A><Y><I><Y><Q><N><E><H><E><V><G><E><A><I><R><E><K><I><A><E><G><K><V><R><R><E><D><I><F><Y><C><G><K><L><W><A><T><N><H><V><P><E><M><V><R><P><T><L><E><R><T><L><R><V><L><Q><L><D><Y><V><D><L><Y><I><I><E><V><P><M><A><F><K><P><G><D><E><I><Y><P><R><D><E><N><G><K><W><L><Y><H><K><S><N><L><C><A><T><W><E><A><M><E><A><C><K><D><A><G><L><V><K><S><L><G><V><S><N><F><N><R><R><Q><L><E><L><I><L><N><K><P><G><L><K><H><K><P><V><S><N><Q><V><E><C><H><P><Y><F><T><Q><P><K><L><L><K><F><C><Q><Q><H><D><I><V><I><T><A><Y><S><P><L><G><T><S><R><N><P><I><W><V><N><V><S><S><P><P><L><L><K><D><A><L><L><N><S><L><G><K><R><Y><N><K><T><A><A><Q><I><V><L><R><F><N><I><Q><R><G><V><V><V><I><P><K><S><F><N><L><E><R><I><K><E><N><F><Q><I><F><D><F><S><L><T><E><E><E><M><K><D><I><E><A><L><N><K><N><V><R><F><V><E><L><L><M><W><R><D><H><P><E><Y><P><F><H><D><E><Y>
Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).<BOP>
P51857
Q8IZN7
D107A_HUMAN
Defensin, beta 107
Homo
<M><P><G><A><M><K><I><F><V><F><I><L><A><A><L><I><L><L><A><Q><I><F><Q><A><R><T><A><I><H><R><A><L><I><S><K><R><M><E><G><H><C><E><A><E><C><L><T><F><E><V><K><I><G><G><C><R><A><E><L><A><P><F><C><C><K><N><R><K><K><H>
Has antibacterial activity.<BOP>
Q8IZN7
Q8N2Z9
CENPS_HUMAN
Fanconi anemia-associated polypeptide of 16 kDa
Homo
<M><E><E><E><A><E><T><E><E><Q><Q><R><F><S><Y><Q><Q><R><L><K><A><A><V><H><Y><T><V><G><C><L><C><E><E><V><A><L><D><K><E><M><Q><F><S><K><Q><T><I><A><A><I><S><E><L><T><F><R><Q><C><E><N><F><A><K><D><L><E><M><F><A><R><H><A><K><R><T><T><I><N><T><E><D><V><K><L><L><A><R><R><S><N><S><L><L><K><Y><I><T><D><K><S><E><E><I><A><Q><I><N><L><E><R><K><A><Q><K><K><K><K><S><E><D><G><S><K><N><S><R><Q><P><A><E><A><G><V><V><E><S><E><N>
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage . In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM . In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks . In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression . As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure . DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay
Q8N2Z9
A0A075B6T8
TVA91_HUMAN
T cell receptor alpha variable 9-1
Homo
<M><N><S><S><P><G><P><A><I><A><L><F><L><M><F><G><G><I><N><G><D><S><V><V><Q><T><E><G><Q><V><L><P><S><E><G><D><S><L><I><V><N><C><S><Y><E><T><T><Q><Y><P><S><L><F><W><Y><V><Q><Y><P><G><E><G><P><Q><L><H><L><K><A><M><K><A><N><D><K><G><R><N><K><G><F><E><A><M><Y><R><K><E><T><T><S><F><H><L><E><K><D><S><V><Q><E><S><D><S><A><V><Y><F><C><A><L><S>
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A075B6T8
Q08257
QOR_HUMAN
Zeta-crystallin
Homo
<M><A><T><G><Q><K><L><M><R><A><V><R><V><F><E><F><G><G><P><E><V><L><K><L><R><S><D><I><A><V><P><I><P><K><D><H><Q><V><L><I><K><V><H><A><C><G><V><N><P><V><E><T><Y><I><R><S><G><T><Y><S><R><K><P><L><L><P><Y><T><P><G><S><D><V><A><G><V><I><E><A><V><G><D><N><A><S><A><F><K><K><G><D><R><V><F><T><S><S><T><I><S><G><G><Y><A><E><Y><A><L><A><A><D><H><T><V><Y><K><L><P><E><K><L><D><F><K><Q><G><A><A><I><G><I><P><Y><F><T><A><Y><R><A><L><I><H><S><A><C><V><K><A><G><E><S><V><L><V><H><G><A><S><G><G><V><G><L><A><A><C><Q><I><A><R><A><Y><G><L><K><I><L><G><T><A><G><T><E><E><G><Q><K><I><V><L><Q><N><G><A><H><E><V><F><N><H><R><E><V><N><Y><I><D><K><I><K><K><Y><V><G><E><K><G><I><D><I><I><I><E><M><L><A><N><V><N><L><S><K><D><L><S><L><L><S><H><G><G><R><V><I><V><V><G><S><R><G><T><I><E><I><N><P><R><D><T><M><A><K><E><S><S><I><I><G><V><T><L><F><S><S><T><K><E><E><F><Q><Q><Y><A><A><A><L><Q><A><G><M><E><I><G><W><L><K><P><V><I><G><S><Q><Y><P><L><E><K><V><A><E><A><H><E><N><I><I><H><G><S><G><A><T><G><K><M><I><L><L><L>
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.<BOP>
Q08257
Q8NGH7
O52L1_HUMAN
Olfactory receptor OR11-50
Homo
<M><T><L><V><S><F><F><S><F><L><S><K><P><L><I><M><L><L><S><N><S><S><W><R><L><S><Q><P><S><F><L><L><V><G><I><P><G><L><E><E><S><Q><H><W><I><A><L><P><L><G><I><L><Y><L><L><A><L><V><G><N><V><T><I><L><F><I><I><W><M><D><P><S><L><H><Q><S><M><Y><L><F><L><S><M><L><A><A><I><D><L><V><L><A><S><S><T><A><P><K><A><L><A><V><L><L><V><H><A><H><E><I><G><Y><I><V><C><L><I><Q><M><F><F><I><H><A><F><S><S><M><E><S><G><V><L><V><A><M><A><L><D><C><Y><V><A><I><C><H><P><L><H><H><S><T><I><L><H><P><G><V><I><G><C><I><G><M><V><V><L><V><R><G><L><L><L><L><I><P><F><P><I><L><L><G><K><L><I><F><C><Q><A><T><I><I><G><H><A><Y><C><E><H><M><A><V><V><K><L><A><C><S><E><T><T><V><N><R><A><Y><G><L><T><M><A><L><L><V><I><G><L><D><V><L><A><I><G><V><S><Y><A><H><I><L><Q><A><V><L><K><V><P><G><S><E><A><R><L><K><A><F><S><T><C><G><S><H><I><C><V><I><L><V><F><Y><V><P><G><I><F><S><F><L><T><H><R><F><G><H><H><V><P><H><H><V><H><V><L><L><A><T><W><Y><L><L><M><P><P><A><L><N><P><L><V><Y><G><V><K><T><Q><Q><I><R><Q><R><V><L><R><V><F><T><Q><K><D>
Odorant receptor.<BOP>
Q8NGH7
Q9P0V9
SEP10_HUMAN
Septin-10
Homo
<M><A><S><S><E><V><A><R><H><L><L><F><Q><S><H><M><A><T><K><T><T><C><M><S><S><Q><G><S><D><D><E><Q><I><K><R><E><N><I><R><S><L><T><M><S><G><H><V><G><F><E><S><L><P><D><Q><L><V><N><R><S><I><Q><Q><G><F><C><F><N><I><L><C><V><G><E><T><G><I><G><K><S><T><L><I><D><T><L><F><N><T><N><F><E><D><Y><E><S><S><H><F><C><P><N><V><K><L><K><A><Q><T><Y><E><L><Q><E><S><N><V><Q><L><K><L><T><I><V><N><T><V><G><F><G><D><Q><I><N><K><E><E><S><Y><Q><P><I><V><D><Y><I><D><A><Q><F><E><A><Y><L><Q><E><E><L><K><I><K><R><S><L><F><T><Y><H><D><S><R><I><H><V><C><L><Y><F><I><S><P><T><G><H><S><L><K><T><L><D><L><L><T><M><K><N><L><D><S><K><V><N><I><I><P><V><I><A><K><A><D><T><V><S><K><T><E><L><Q><K><F><K><I><K><L><M><S><E><L><V><S><N><G><V><Q><I><Y><Q><F><P><T><D><D><D><T><I><A><K><V><N><A><A><M><N><G><Q><L><P><F><A><V><V><G><S><M><D><E><V><K><V><G><N><K><M><V><K><A><R><Q><Y><P><W><G><V><V><Q><V><E><N><E><N><H><C><D><F><V><K><L><R><E><M><L><I><C><T><N><M><E><D><L><R><E><Q><T><H><T><R><H><Y><E><L><Y><R><R><C><K><L><E><E><M><G><F><T><D><V><G><P><E><N><K><P><V><S><V><Q><E><T><Y><E><A><K><R><H><E><F><H><G><E><R><Q><R><K><E><E><E><M><K><Q><M><F><V><Q><R><V><K><E><K><E><A><I><L><K><E><A><E><R><E><L><Q><A><K><F><E><H><L><K><R><L><H><Q><E><E><R><M><K><L><E><E><K><R><R><L><L><E><E><E><I><I><A><F><S><K><K><K><A><T><S><E><I><F><H><S><Q><S><F><L><A><T><G><S><N><L><R><K><D><K><D><R><K><N><S><N><F><L>
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).<BOP>
Q9P0V9
P17023
ZNF19_HUMAN
Zinc finger protein KOX12
Homo
<M><A><A><M><P><L><K><A><Q><Y><Q><E><M><V><T><F><E><D><V><A><V><H><F><T><K><T><E><W><T><G><L><S><P><A><Q><R><A><L><Y><R><S><V><M><L><E><N><F><G><N><L><T><A><L><G><Y><P><V><P><K><P><A><L><I><S><L><L><E><R><G><D><M><A><W><G><L><E><A><Q><D><D><P><P><A><E><R><T><K><N><V><C><K><D><V><E><T><N><I><D><S><E><S><T><L><I><Q><G><I><S><E><E><R><D><G><M><M><S><H><G><Q><L><K><S><V><P><Q><R><T><D><F><P><E><T><R><N><V><E><K><H><Q><D><I><P><T><V><K><N><I><Q><G><K><V><P><R><I><P><C><A><R><K><P><F><I><C><E><E><C><G><K><S><F><S><Y><F><S><Y><Y><A><R><H><Q><R><I><H><T><G><E><K><P><F><E><C><S><E><C><G><K><A><F><N><G><N><S><S><L><I><R><H><Q><R><I><H><T><G><E><R><P><Y><Q><C><E><E><C><G><R><A><F><N><D><N><A><N><L><I><R><H><Q><R><I><H><S><G><D><R><P><Y><Y><C><T><E><C><G><N><S><F><T><S><S><S><E><F><V><I><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><V><G><N><S><P><L><L><R><H><Q><K><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><S><F><G><R><T><S><H><L><S><Q><H><Q><R><I><H><T><G><E><K><P><Y><S><C><K><V><C><G><Q><A><F><N><F><H><T><K><L><T><R><H><Q><R><I><H><S><E><E><K><P><F><D><C><V><D><C><G><K><A><F><S><A><Q><E><Q><L><K><R><H><L><R><I><H><T><Q><E><S><S><Y><V><C><D><E><C><G><K><A><L><T><S><K><R><N><L><H><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><K><Y><E><K><A><F><G><T><S><S><Q><L><G><H><L><E><H><V><Y><S><G><E><K><P><V><L><D><I><C><R><F><G><L><P><E><F><F><T><P><F><Y><W>
May be involved in transcriptional regulation.<BOP>
P17023
Q99733
NP1L4_HUMAN
Nucleosome assembly protein 2
Homo
<M><A><D><H><S><F><S><D><G><V><P><S><D><S><V><E><A><A><K><N><A><S><N><T><E><K><L><T><D><Q><V><M><Q><N><P><R><V><L><A><A><L><Q><E><R><L><D><N><V><P><H><T><P><S><S><Y><I><E><T><L><P><K><A><V><K><R><R><I><N><A><L><K><Q><L><Q><V><R><C><A><H><I><E><A><K><F><Y><E><E><V><H><D><L><E><R><K><Y><A><A><L><Y><Q><P><L><F><D><K><R><R><E><F><I><T><G><D><V><E><P><T><D><A><E><S><E><W><H><S><E><N><E><E><E><E><K><L><A><G><D><M><K><S><K><V><V><V><T><E><K><A><A><A><T><A><E><E><P><D><P><K><G><I><P><E><F><W><F><T><I><F><R><N><V><D><M><L><S><E><L><V><Q><E><Y><D><E><P><I><L><K><H><L><Q><D><I><K><V><K><F><S><D><P><G><Q><P><M><S><F><V><L><E><F><H><F><E><P><N><D><Y><F><T><N><S><V><L><T><K><T><Y><K><M><K><S><E><P><D><K><A><D><P><F><S><F><E><G><P><E><I><V><D><C><D><G><C><T><I><D><W><K><K><G><K><N><V><T><V><K><T><I><K><K><K><Q><K><H><K><G><R><G><T><V><R><T><I><T><K><Q><V><P><N><E><S><F><F><N><F><F><N><P><L><K><A><S><G><D><G><E><S><L><D><E><D><S><E><F><T><L><A><S><D><F><E><I><G><H><F><F><R><E><R><I><V><P><R><A><V><L><Y><F><T><G><E><A><I><E><D><D><D><N><F><E><E><G><E><E><G><E><E><E><E><L><E><G><D><E><E><G><E><D><E><D><D><A><E><I><N><P><K><V>
Acts as histone chaperone in nucleosome assembly.<BOP>
Q99733
Q8NH19
O10AG_HUMAN
Olfactory receptor OR11-160
Homo
<M><E><F><V><L><L><G><F><S><D><I><P><N><L><H><W><M><L><F><S><I><F><L><L><M><Y><L><M><I><L><M><C><N><G><I><I><I><L><L><I><K><I><H><P><A><L><Q><T><P><M><Y><F><F><L><S><N><F><S><L><L><E><I><C><Y><V><T><I><I><I><P><R><M><L><M><D><I><W><T><Q><K><G><N><I><S><L><F><A><C><A><T><Q><M><C><F><F><L><M><L><G><G><T><E><C><L><L><L><T><V><M><A><Y><D><R><Y><V><A><I><C><K><P><L><Q><Y><P><L><V><M><N><H><K><V><C><I><Q><L><I><I><A><S><W><T><I><T><I><P><V><V><I><G><E><T><C><Q><I><F><L><L><P><F><C><G><T><N><T><I><N><H><F><F><C><D><I><P><P><I><L><K><L><A><C><G><N><I><F><V><N><E><I><T><V><H><V><V><A><V><V><F><I><T><V><P><F><L><L><I><V><V><S><Y><G><K><I><I><S><N><I><L><K><L><S><S><A><R><G><K><A><K><A><F><S><T><C><S><S><H><L><I><V><V><I><L><F><F><G><A><G><T><I><T><Y><L><Q><P><K><P><H><Q><F><Q><R><M><G><K><L><I><S><L><F><Y><T><I><L><I><P><T><L><N><P><I><I><Y><T><L><R><N><K><D><I><M><V><A><L><R><K><L><L><A><K><L><L><T>
Odorant receptor.<BOP>
Q8NH19
Q9NR22
ANM8_HUMAN
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4
Homo
<M><G><M><K><H><S><S><R><C><L><L><L><R><R><K><M><A><E><N><A><A><E><S><T><E><V><N><S><P><P><S><Q><P><P><Q><P><V><V><P><A><K><P><V><Q><C><V><H><H><V><S><T><Q><P><S><C><P><G><R><G><K><M><S><K><L><L><N><P><E><E><M><T><S><R><D><Y><Y><F><D><S><Y><A><H><F><G><I><H><E><E><M><L><K><D><E><V><R><T><L><T><Y><R><N><S><M><Y><H><N><K><H><V><F><K><D><K><V><V><L><D><V><G><S><G><T><G><I><L><S><M><F><A><A><K><A><G><A><K><K><V><F><G><I><E><C><S><S><I><S><D><Y><S><E><K><I><I><K><A><N><H><L><D><N><I><I><T><I><F><K><G><K><V><E><E><V><E><L><P><V><E><K><V><D><I><I><I><S><E><W><M><G><Y><C><L><F><Y><E><S><M><L><N><T><V><I><F><A><R><D><K><W><L><K><P><G><G><L><M><F><P><D><R><A><A><L><Y><V><V><A><I><E><D><R><Q><Y><K><D><F><K><I><H><W><W><E><N><V><Y><G><F><D><M><T><C><I><R><D><V><A><M><K><E><P><L><V><D><I><V><D><P><K><Q><V><V><T><N><A><C><L><I><K><E><V><D><I><Y><T><V><K><T><E><E><L><S><F><T><S><A><F><C><L><Q><I><Q><R><N><D><Y><V><H><A><L><V><T><Y><F><N><I><E><F><T><K><C><H><K><K><M><G><F><S><T><A><P><D><A><P><Y><T><H><W><K><Q><T><V><F><Y><L><E><D><Y><L><T><V><R><R><G><E><E><I><Y><G><T><I><S><M><K><P><N><A><K><N><V><R><D><L><D><F><T><V><D><L><D><F><K><G><Q><L><C><E><T><S><V><S><N><D><Y><K><M><R>
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer . Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS .<BOP>
Q9NR22
Q86UE6
LRRT1_HUMAN
Leucine-rich repeat transmembrane neuronal protein 1
Homo
<M><D><F><L><L><L><G><L><C><L><Y><W><L><L><R><R><P><S><G><V><V><L><C><L><L><G><A><C><F><Q><M><L><P><A><A><P><S><G><C><P><Q><L><C><R><C><E><G><R><L><L><Y><C><E><A><L><N><L><T><E><A><P><H><N><L><S><G><L><L><G><L><S><L><R><Y><N><S><L><S><E><L><R><A><G><Q><F><T><G><L><M><Q><L><T><W><L><Y><L><D><H><N><H><I><C><S><V><Q><G><D><A><F><Q><K><L><R><R><V><K><E><L><T><L><S><S><N><Q><I><T><Q><L><P><N><T><T><F><R><P><M><P><N><L><R><S><V><D><L><S><Y><N><K><L><Q><A><L><A><P><D><L><F><H><G><L><R><K><L><T><T><L><H><M><R><A><N><A><I><Q><F><V><P><V><R><I><F><Q><D><C><R><S><L><K><F><L><D><I><G><Y><N><Q><L><K><S><L><A><R><N><S><F><A><G><L><F><K><L><T><E><L><H><L><E><H><N><D><L><V><K><V><N><F><A><H><F><P><R><L><I><S><L><H><S><L><C><L><R><R><N><K><V><A><I><V><V><S><S><L><D><W><V><W><N><L><E><K><M><D><L><S><G><N><E><I><E><Y><M><E><P><H><V><F><E><T><V><P><H><L><Q><S><L><Q><L><D><S><N><R><L><T><Y><I><E><P><R><I><L><N><S><W><K><S><L><T><S><I><T><L><A><G><N><L><W><D><C><G><R><N><V><C><A><L><A><S><W><L><N><N><F><Q><G><R><Y><D><G><N><L><Q><C><A><S><P><E><Y><A><Q><G><E><D><V><L><D><A><V><Y><A><F><H><L><C><E><D><G><A><E><P><T><S><G><H><L><L><S><A><V><T><N><R><S><D><L><G><P><P><A><S><S><A><T><T><L><A><D><G><G><E><G><Q><H><D><G><T><F><E><P><A><T><V><A><L><P><G><G><E><H><A><E><N><A><V><Q><I><H><K><V><V><T><G><T><M><A><L><I><F><S><F><L><I><V><V><L><V><L><Y><V><S><W><K><C><F><P><A><S><L><R><Q><L><R><Q><C><F><V><T><Q><R><R><K><Q><K><Q><K><Q><T><M><H><Q><M><A><A><M><S><A><Q><E><Y><Y><V><D><Y><K><P><N><H><I><E><G><A><L><V><I><I><N><E><Y><G><S><C><T><C><H><Q><Q><P><A><R><E><C><E><V>
Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.<BOP>
Q86UE6
P15291
B4GT1_HUMAN
Processed beta-1,4-galactosyltransferase 1
Homo
<M><R><L><R><E><P><L><L><S><G><S><A><A><M><P><G><A><S><L><Q><R><A><C><R><L><L><V><A><V><C><A><L><H><L><G><V><T><L><V><Y><Y><L><A><G><R><D><L><S><R><L><P><Q><L><V><G><V><S><T><P><L><Q><G><G><S><N><S><A><A><A><I><G><Q><S><S><G><E><L><R><T><G><G><A><R><P><P><P><P><L><G><A><S><S><Q><P><R><P><G><G><D><S><S><P><V><V><D><S><G><P><G><P><A><S><N><L><T><S><V><P><V><P><H><T><T><A><L><S><L><P><A><C><P><E><E><S><P><L><L><V><G><P><M><L><I><E><F><N><M><P><V><D><L><E><L><V><A><K><Q><N><P><N><V><K><M><G><G><R><Y><A><P><R><D><C><V><S><P><H><K><V><A><I><I><I><P><F><R><N><R><Q><E><H><L><K><Y><W><L><Y><Y><L><H><P><V><L><Q><R><Q><Q><L><D><Y><G><I><Y><V><I><N><Q><A><G><D><T><I><F><N><R><A><K><L><L><N><V><G><F><Q><E><A><L><K><D><Y><D><Y><T><C><F><V><F><S><D><V><D><L><I><P><M><N><D><H><N><A><Y><R><C><F><S><Q><P><R><H><I><S><V><A><M><D><K><F><G><F><S><L><P><Y><V><Q><Y><F><G><G><V><S><A><L><S><K><Q><Q><F><L><T><I><N><G><F><P><N><N><Y><W><G><W><G><G><E><D><D><D><I><F><N><R><L><V><F><R><G><M><S><I><S><R><P><N><A><V><V><G><R><C><R><M><I><R><H><S><R><D><K><K><N><E><P><N><P><Q><R><F><D><R><I><A><H><T><K><E><T><M><L><S><D><G><L><N><S><L><T><Y><Q><V><L><D><V><Q><R><Y><P><L><Y><T><Q><I><T><V><D><I><G><T><P><S>
The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.<BOP>
P15291
P82251
BAT1_HUMAN
Solute carrier family 7 member 9
Homo
<M><G><D><T><G><L><R><K><R><R><E><D><E><K><S><I><Q><S><Q><E><P><K><T><T><S><L><Q><K><E><L><G><L><I><S><G><I><S><I><I><V><G><T><I><I><G><S><G><I><F><V><S><P><K><S><V><L><S><N><T><E><A><V><G><P><C><L><I><I><W><A><A><C><G><V><L><A><T><L><G><A><L><C><F><A><E><L><G><T><M><I><T><K><S><G><G><E><Y><P><Y><L><M><E><A><Y><G><P><I><P><A><Y><L><F><S><W><A><S><L><I><V><I><K><P><T><S><F><A><I><I><C><L><S><F><S><E><Y><V><C><A><P><F><Y><V><G><C><K><P><P><Q><I><V><V><K><C><L><A><A><A><A><I><L><F><I><S><T><V><N><S><L><S><V><R><L><G><S><Y><V><Q><N><I><F><T><A><A><K><L><V><I><V><A><I><I><I><I><S><G><L><V><L><L><A><Q><G><N><T><K><N><F><D><N><S><F><E><G><A><Q><L><S><V><G><A><I><S><L><A><F><Y><N><G><L><W><A><Y><D><G><W><N><Q><L><N><Y><I><T><E><E><L><R><N><P><Y><R><N><L><P><L><A><I><I><I><G><I><P><L><V><T><A><C><Y><I><L><M><N><V><S><Y><F><T><V><M><T><A><T><E><L><L><Q><S><Q><A><V><A><V><T><F><G><D><R><V><L><Y><P><A><S><W><I><V><P><L><F><V><A><F><S><T><I><G><A><A><N><G><T><C><F><T><A><G><R><L><I><Y><V><A><G><R><E><G><H><M><L><K><V><L><S><Y><I><S><V><R><R><L><T><P><A><P><A><I><I><F><Y><G><I><I><A><T><I><Y><I><I><P><G><D><I><N><S><L><V><N><Y><F><S><F><A><A><W><L><F><Y><G><L><T><I><L><G><L><I><V><M><R><F><T><R><K><E><L><E><R><P><I><K><V><P><V><V><I><P><V><L><M><T><L><I><S><V><F><L><V><L><A><P><I><I><S><K><P><T><W><E><Y><L><Y><C><V><L><F><I><L><S><G><L><L><F><Y><F><L><F><V><H><Y><K><F><G><W><A><Q><K><I><S><K><P><I><T><M><H><L><Q><M><L><M><E><V><V><P><P><E><E><D><P><E>
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.<BOP>
P82251
Q9NVW2
RNF12_HUMAN
Renal carcinoma antigen NY-REN-43
Homo
<M><E><N><S><D><S><N><D><K><G><S><G><D><Q><S><A><A><Q><R><R><S><Q><M><D><R><L><D><R><E><E><A><F><Y><Q><F><V><N><N><L><S><E><E><D><Y><R><L><M><R><D><N><N><L><L><G><T><P><G><E><S><T><E><E><E><L><L><R><R><L><Q><Q><I><K><E><G><P><P><P><Q><N><S><D><E><N><R><G><G><D><S><S><D><D><V><S><N><G><D><S><I><I><D><W><L><N><S><V><R><Q><T><G><N><T><T><R><S><G><Q><R><G><N><Q><S><W><R><A><V><S><R><T><N><P><N><S><G><D><F><R><F><S><L><E><I><N><V><N><R><N><N><G><S><Q><N><S><E><N><E><N><E><P><S><A><R><R><S><S><G><E><N><V><E><N><N><S><Q><R><Q><V><E><N><P><R><S><E><S><T><S><A><R><P><S><R><S><E><R><N><S><T><E><A><L><T><E><V><P><P><T><R><G><Q><R><R><A><R><S><R><S><P><D><H><R><R><T><R><A><R><A><E><R><S><R><S><P><L><H><P><M><S><E><I><P><R><R><S><H><H><S><I><S><S><Q><T><F><E><H><P><L><V><N><E><T><E><G><S><S><R><T><R><H><H><V><T><L><R><Q><Q><I><S><G><P><E><L><L><S><R><G><L><F><A><A><S><G><T><R><N><A><S><Q><G><A><G><S><S><D><T><A><A><S><G><E><S><T><G><S><G><Q><R><P><P><T><I><V><L><D><L><Q><V><R><R><V><R><P><G><E><Y><R><Q><R><D><S><I><A><S><R><T><R><S><R><S><Q><T><P><N><N><T><V><T><Y><E><S><E><R><G><G><F><R><R><T><F><S><R><S><E><R><A><G><V><R><T><Y><V><S><T><I><R><I><P><I><R><R><I><L><N><T><G><L><S><E><T><T><S><V><A><I><Q><T><M><L><R><Q><I><M><T><G><F><G><E><L><S><Y><F><M><Y><S><D><S><D><S><E><P><T><G><S><V><S><N><R><N><M><E><R><A><E><S><R><S><G><R><G><G><S><G><G><G><S><S><S><G><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><S><P><S><S><S><S><G><G><E><S><S><E><T><S><S><D><L><F><E><G><S><N><E><G><S><S><S><S><G><S><S><G><A><R><R><E><G><R><H><R><A><P><V><T><F><D><E><S><G><S><L><P><F><L><S><L><A><Q><F><F><L><L><N><E><D><D><D><D><Q><P><R><G><L><T><K><E><Q><I><D><N><L><A><M><R><S><F><G><E><N><D><A><L><K><T><C><S><V><C><I><T><E><Y><T><E><G><N><K><L><R><K><L><P><C><S><H><E><Y><H><V><H><C><I><D><R><W><L><S><E><N><S><T><C><P><I><C><R><R><A><V><L><A><S><G><N><R><E><S><V><V>
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.<BOP>
Q9NVW2
Q9UM13
APC10_HUMAN
Cyclosome subunit 10
Homo
<M><T><T><P><N><K><T><P><P><G><A><D><P><K><Q><L><E><R><T><G><T><V><R><E><I><G><S><Q><A><V><W><S><L><S><S><C><K><P><G><F><G><V><D><Q><L><R><D><D><N><L><E><T><Y><W><Q><S><D><G><S><Q><P><H><L><V><N><I><Q><F><R><R><K><T><T><V><K><T><L><C><I><Y><A><D><Y><K><S><D><E><S><Y><T><P><S><K><I><S><V><R><V><G><N><N><F><H><N><L><Q><E><I><R><Q><L><E><L><V><E><P><S><G><W><I><H><V><P><L><T><D><N><H><K><K><P><T><R><T><F><M><I><Q><I><A><V><L><A><N><H><Q><N><G><R><D><T><H><M><R><Q><I><K><I><Y><T><P><V><E><E><S><S><I><G><K><F><P><R><C><T><T><I><D><F><M><M><Y><R><S><I><R>
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<BOP>
Q9UM13
O43325
LYRM1_HUMAN
LYR motif-containing protein 1
Homo
<M><T><T><A><T><R><Q><E><V><L><G><L><Y><R><S><I><F><R><L><A><R><K><W><Q><A><T><S><G><Q><M><E><D><T><I><K><E><K><Q><Y><I><L><N><E><A><R><T><L><F><R><K><N><K><N><L><T><D><T><D><L><I><K><Q><C><I><D><E><C><T><A><R><I><E><I><G><L><H><Y><K><I><P><Y><P><R><P><I><H><L><P><P><M><G><L><T><P><L><R><G><R><G><L><R><S><Q><E><K><L><R><K><L><S><K><P><V><Y><L><R><S><H><D><E><V><S>
May promote cell proliferation and inhibition of apoptosis of preadipocytes.<BOP>
O43325
Q9BT17
MTG1_HUMAN
Mitochondrial GTPase 1
Homo
<M><R><L><T><P><R><A><L><C><S><A><A><Q><A><A><W><R><E><N><F><P><L><C><G><R><D><V><A><R><W><F><P><G><H><M><A><K><G><L><K><K><M><Q><S><S><L><K><L><V><D><C><I><I><E><V><H><D><A><R><I><P><L><S><G><R><N><P><L><F><Q><E><T><L><G><L><K><P><H><L><L><V><L><N><K><M><D><L><A><D><L><T><E><Q><Q><K><I><M><Q><H><L><E><G><E><G><L><K><N><V><I><F><T><N><C><V><K><D><E><N><V><K><Q><I><I><P><M><V><T><E><L><I><G><R><S><H><R><Y><H><R><K><E><N><L><E><Y><C><I><M><V><I><G><V><P><N><V><G><K><S><S><L><I><N><S><L><R><R><Q><H><L><R><K><G><K><A><T><R><V><G><G><E><P><G><I><T><R><A><V><M><S><K><I><Q><V><S><E><R><P><L><M><F><L><L><D><T><P><G><V><L><A><P><R><I><E><S><V><E><T><G><L><K><L><A><L><C><G><T><V><L><D><H><L><V><G><E><E><T><M><A><D><Y><L><L><Y><T><L><N><K><H><Q><R><F><G><Y><V><Q><H><Y><G><L><G><S><A><C><D><N><V><E><R><V><L><K><S><V><A><V><K><L><G><K><T><Q><K><V><K><V><L><T><G><T><G><N><V><N><I><I><Q><P><N><Y><P><A><A><A><R><D><F><L><Q><T><F><R><R><G><L><L><G><S><V><M><L><D><L><D><V><L><R><G><H><P><P><A><E><T><L><P>
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.<BOP>
Q9BT17
Q96FE7
P3IP1_HUMAN
Kringle domain-containing protein HGFL
Homo
<M><L><L><A><W><V><Q><A><F><L><V><S><N><M><L><L><A><E><A><Y><G><S><G><G><C><F><W><D><N><G><H><L><Y><R><E><D><Q><T><S><P><A><P><G><L><R><C><L><N><W><L><D><A><Q><S><G><L><A><S><A><P><V><S><G><A><G><N><H><S><Y><C><R><N><P><D><E><D><P><R><G><P><W><C><Y><V><S><G><E><A><G><V><P><E><K><R><P><C><E><D><L><R><C><P><E><T><T><S><Q><A><L><P><A><F><T><T><E><I><Q><E><A><S><E><G><P><G><A><D><E><V><Q><V><F><A><P><A><N><A><L><P><A><R><S><E><A><A><A><V><Q><P><V><I><G><I><S><Q><R><V><R><M><N><S><K><E><K><K><D><L><G><T><L><G><Y><V><L><G><I><T><M><M><V><I><I><I><A><I><G><A><G><I><I><L><G><Y><S><Y><K><R><G><K><D><L><K><E><Q><H><D><Q><K><V><C><E><R><E><M><Q><R><I><T><L><P><L><S><A><F><T><N><P><T><C><E><I><V><D><E><K><T><V><V><V><H><T><S><Q><T><P><V><D><P><Q><E><G><T><T><P><L><M><G><Q><A><G><T><P><G><A>
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.<BOP>
Q96FE7
P41145
OPRK_HUMAN
Kappa-type opioid receptor
Homo
<M><D><S><P><I><Q><I><F><R><G><E><P><G><P><T><C><A><P><S><A><C><L><P><P><N><S><S><A><W><F><P><G><W><A><E><P><D><S><N><G><S><A><G><S><E><D><A><Q><L><E><P><A><H><I><S><P><A><I><P><V><I><I><T><A><V><Y><S><V><V><F><V><V><G><L><V><G><N><S><L><V><M><F><V><I><I><R><Y><T><K><M><K><T><A><T><N><I><Y><I><F><N><L><A><L><A><D><A><L><V><T><T><T><M><P><F><Q><S><T><V><Y><L><M><N><S><W><P><F><G><D><V><L><C><K><I><V><I><S><I><D><Y><Y><N><M><F><T><S><I><F><T><L><T><M><M><S><V><D><R><Y><I><A><V><C><H><P><V><K><A><L><D><F><R><T><P><L><K><A><K><I><I><N><I><C><I><W><L><L><S><S><S><V><G><I><S><A><I><V><L><G><G><T><K><V><R><E><D><V><D><V><I><E><C><S><L><Q><F><P><D><D><D><Y><S><W><W><D><L><F><M><K><I><C><V><F><I><F><A><F><V><I><P><V><L><I><I><I><V><C><Y><T><L><M><I><L><R><L><K><S><V><R><L><L><S><G><S><R><E><K><D><R><N><L><R><R><I><T><R><L><V><L><V><V><V><A><V><F><V><V><C><W><T><P><I><H><I><F><I><L><V><E><A><L><G><S><T><S><H><S><T><A><A><L><S><S><Y><Y><F><C><I><A><L><G><Y><T><N><S><S><L><N><P><I><L><Y><A><F><L><D><E><N><F><K><R><C><F><R><D><F><C><F><P><L><K><M><R><M><E><R><Q><S><T><S><R><V><R><N><T><V><Q><D><P><A><Y><L><R><D><I><D><G><M><N><K><P><V>
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<BOP>
P41145
P22528
SPR1B_HUMAN
Small proline-rich protein IB
Homo
<M><S><S><Q><Q><Q><K><Q><P><C><T><P><P><P><Q><L><Q><Q><Q><Q><V><K><Q><P><C><Q><P><P><P><Q><E><P><C><I><P><K><T><K><E><P><C><H><P><K><V><P><E><P><C><H><P><K><V><P><E><P><C><Q><P><K><V><P><E><P><C><H><P><K><V><P><E><P><C><P><S><I><V><T><P><A><P><A><Q><Q><K><T><K><Q><K>
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.<BOP>
P22528
Q6XLA1
CSC2A_HUMAN
Cancer susceptibility candidate gene 2 protein, isoform 3
Homo
<M><T><Q><E><K><M><Y><P><H><L><F><S><E><R><C><A><N><Q><H><Q><H><R><T><A><E><E><K><K><Y><V><S><E><K><Q><L><I><H><W><R><C><E><E><P><S><A><H><H><N><S><I><D><I><K><R><M><K><H><F><G><S><A><L><R><L><R><Q><T><F><H><L><D><T><A><D><H><P><C><V><I><T><M><N><P><A><L><P><W><K><L><E><G><S><N><S><T><S><T><L><P><L><P><A>
May act as a potential tumor suppressor.<BOP>
Q6XLA1
Q92783
STAM1_HUMAN
Signal transducing adapter molecule 1
Homo
<M><P><L><F><A><T><N><P><F><D><Q><D><V><E><K><A><T><S><E><M><N><T><A><E><D><W><G><L><I><L><D><I><C><D><K><V><G><Q><S><R><T><G><P><K><D><C><L><R><S><I><M><R><R><V><N><H><K><D><P><H><V><A><M><Q><A><L><T><L><L><G><A><C><V><S><N><C><G><K><I><F><H><L><E><V><C><S><R><D><F><A><S><E><V><S><N><V><L><N><K><G><H><P><K><V><C><E><K><L><K><A><L><M><V><E><W><T><D><E><F><K><N><D><P><Q><L><S><L><I><S><A><M><I><K><N><L><K><E><Q><G><V><T><F><P><A><I><G><S><Q><A><A><E><Q><A><K><A><S><P><A><L><V><A><K><D><P><G><T><V><A><N><K><K><E><E><E><D><L><A><K><A><I><E><L><S><L><K><E><Q><R><Q><Q><S><T><T><L><S><T><L><Y><P><S><T><S><S><L><L><T><N><H><Q><H><E><G><R><K><V><R><A><I><Y><D><F><E><A><A><E><D><N><E><L><T><F><K><A><G><E><I><I><T><V><L><D><D><S><D><P><N><W><W><K><G><E><T><H><Q><G><I><G><L><F><P><S><N><F><V><T><A><D><L><T><A><E><P><E><M><I><K><T><E><K><K><T><V><Q><F><S><D><D><V><Q><V><E><T><I><E><P><E><P><E><P><A><F><I><D><E><D><K><M><D><Q><L><L><Q><M><L><Q><S><T><D><P><S><D><D><Q><P><D><L><P><E><L><L><H><L><E><A><M><C><H><Q><M><G><P><L><I><D><E><K><L><E><D><I><D><R><K><H><S><E><L><S><E><L><N><V><K><V><M><E><A><L><S><L><Y><T><K><L><M><N><E><D><P><M><Y><S><M><Y><A><K><L><Q><N><Q><P><Y><Y><M><Q><S><S><G><V><S><G><S><Q><V><Y><A><G><P><P><P><S><G><A><Y><L><V><A><G><N><A><Q><M><S><H><L><Q><S><Y><S><L><P><P><E><Q><L><S><S><L><S><Q><A><V><V><P><P><S><A><N><P><A><L><P><S><Q><Q><T><Q><A><A><Y><P><N><T><M><V><S><S><V><Q><G><N><T><Y><P><S><Q><A><P><V><Y><S><P><P><P><A><A><T><A><A><A><A><T><A><D><V><T><L><Y><Q><N><A><G><P><N><M><P><Q><V><P><N><Y><N><L><T><S><S><T><L><P><Q><P><G><G><S><Q><Q><P><P><Q><P><Q><Q><P><Y><S><Q><K><A><L><L>
(Microbial infection) Plays an important role in Dengue virus entry.<BOP>
Q92783
Q70HW3
SAMC_HUMAN
Solute carrier family 25 member 26
Homo
<M><D><R><P><G><F><V><A><A><L><V><A><G><G><V><A><G><V><S><V><D><L><I><L><F><P><L><D><T><I><K><T><R><L><Q><S><P><Q><G><F><S><K><A><G><G><F><H><G><I><Y><A><G><V><P><S><A><A><I><G><S><F><P><N><A><A><A><F><F><I><T><Y><E><Y><V><K><W><F><L><H><A><D><S><S><S><Y><L><T><P><M><K><H><M><L><A><A><S><A><G><E><V><V><A><C><L><I><R><V><P><S><E><V><V><K><Q><R><A><Q><V><S><A><S><T><R><T><F><Q><I><F><S><N><I><L><Y><E><E><G><I><Q><G><L><Y><R><G><Y><K><S><T><V><L><R><E><I><P><F><S><L><V><Q><F><P><L><W><E><S><L><K><A><L><W><S><W><R><Q><D><H><V><V><D><S><W><Q><S><A><V><C><G><A><F><A><G><G><F><A><A><A><V><T><T><P><L><D><V><A><K><T><R><I><T><L><A><K><A><G><S><S><T><A><D><G><N><V><L><S><V><L><H><G><V><W><R><S><Q><G><L><A><G><L><F><A><G><V><F><P><R><M><A><A><I><S><L><G><G><F><I><F><L><G><A><Y><D><R><T><H><S><L><L><L><E><V><G><R><K><S><P>
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.<BOP>
Q70HW3
P10606
COX5B_HUMAN
Cytochrome c oxidase polypeptide Vb
Homo
<M><A><S><R><L><L><R><G><A><G><T><L><A><A><Q><A><L><R><A><R><G><P><S><G><A><A><A><M><R><S><M><A><S><G><G><G><V><P><T><D><E><E><Q><A><T><G><L><E><R><E><I><M><L><A><A><K><K><G><L><D><P><Y><N><V><L><A><P><K><G><A><S><G><T><R><E><D><P><N><L><V><P><S><I><S><N><K><R><I><V><G><C><I><C><E><E><D><N><T><S><V><V><W><F><W><L><H><K><G><E><A><Q><R><C><P><R><C><G><A><H><Y><K><L><V><P><Q><Q><L><A><H>
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from
P10606
P42224
STAT1_HUMAN
Transcription factor ISGF-3 components p91/p84
Homo
<M><S><Q><W><Y><E><L><Q><Q><L><D><S><K><F><L><E><Q><V><H><Q><L><Y><D><D><S><F><P><M><E><I><R><Q><Y><L><A><Q><W><L><E><K><Q><D><W><E><H><A><A><N><D><V><S><F><A><T><I><R><F><H><D><L><L><S><Q><L><D><D><Q><Y><S><R><F><S><L><E><N><N><F><L><L><Q><H><N><I><R><K><S><K><R><N><L><Q><D><N><F><Q><E><D><P><I><Q><M><S><M><I><I><Y><S><C><L><K><E><E><R><K><I><L><E><N><A><Q><R><F><N><Q><A><Q><S><G><N><I><Q><S><T><V><M><L><D><K><Q><K><E><L><D><S><K><V><R><N><V><K><D><K><V><M><C><I><E><H><E><I><K><S><L><E><D><L><Q><D><E><Y><D><F><K><C><K><T><L><Q><N><R><E><H><E><T><N><G><V><A><K><S><D><Q><K><Q><E><Q><L><L><L><K><K><M><Y><L><M><L><D><N><K><R><K><E><V><V><H><K><I><I><E><L><L><N><V><T><E><L><T><Q><N><A><L><I><N><D><E><L><V><E><W><K><R><R><Q><Q><S><A><C><I><G><G><P><P><N><A><C><L><D><Q><L><Q><N><W><F><T><I><V><A><E><S><L><Q><Q><V><R><Q><Q><L><K><K><L><E><E><L><E><Q><K><Y><T><Y><E><H><D><P><I><T><K><N><K><Q><V><L><W><D><R><T><F><S><L><F><Q><Q><L><I><Q><S><S><F><V><V><E><R><Q><P><C><M><P><T><H><P><Q><R><P><L><V><L><K><T><G><V><Q><F><T><V><K><L><R><L><L><V><K><L><Q><E><L><N><Y><N><L><K><V><K><V><L><F><D><K><D><V><N><E><R><N><T><V><K><G><F><R><K><F><N><I><L><G><T><H><T><K><V><M><N><M><E><E><S><T><N><G><S><L><A><A><E><F><R><H><L><Q><L><K><E><Q><K><N><A><G><T><R><T><N><E><G><P><L><I><V><T><E><E><L><H><S><L><S><F><E><T><Q><L><C><Q><P><G><L><V><I><D><L><E><T><T><S><L><P><V><V><V><I><S><N><V><S><Q><L><P><S><G><W><A><S><I><L><W><Y><N><M><L><V><A><E><P><R><N><L><S><F><F><L><T><P><P><C><A><R><W><A><Q><L><S><E><V><L><S><W><Q><F><S><S><V><T><K><R><G><L><N><V><D><Q><L><N><M><L><G><E><K><L><L><G><P><N><A><S><P><D><G><L><I><P><W><T><R><F><C><K><E><N><I><N><D><K><N><F><P><F><W><L><W><I><E><S><I><L><E><L><I><K><K><H><L><L><P><L><W><N><D><G><C><I><M><G><F><I><S><K><E><R><E><R><A><L><L><K><D><Q><Q><P><G><T><F><L><L><R><F><S><E><S><S><R><E><G><A><I><T><F><T><W><V><E><R><S><Q><N><G><G><E><P><D><F><H><A><V><E><P><Y><T><K><K><E><L><S><A><V><T><F><P><D><I><I><R><N><Y><K><V><M><A><A><E><N><I><P><E><N><P><L><K><Y><L><Y><P><N><I><D><K><D><H><A><F><G><K><Y><Y><S><R><P><K><E><A><P><E><P><M><E><L><D><G><P><K><G><T><G><Y><I><K><T><E><L><I><S><V><S><E><V><H><P><S><R><L><Q><T><T><D><N><L><L><P><M><S><P><E><E><F><D><E><V><S><R><I><V><G><S><V><E><F><D><S><M><M><N><T><V>
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus . ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated . It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to
P42224
Q8TAV3
CP2W1_HUMAN
CYPIIW1
Homo
<M><A><L><L><L><L><L><F><L><G><L><L><G><L><W><G><L><L><C><A><C><A><Q><D><P><S><P><A><A><R><W><P><P><G><P><R><P><L><P><L><V><G><N><L><H><L><L><R><L><S><Q><Q><D><R><S><L><M><E><L><S><E><R><Y><G><P><V><F><T><V><H><L><G><R><Q><K><T><V><V><L><T><G><F><E><A><V><K><E><A><L><A><G><P><G><Q><E><L><A><D><R><P><P><I><A><I><F><Q><L><I><Q><R><G><G><G><I><F><F><S><S><G><A><R><W><R><A><A><R><Q><F><T><V><R><A><L><H><S><L><G><V><G><R><E><P><V><A><D><K><I><L><Q><E><L><K><C><L><S><G><Q><L><D><G><Y><R><G><R><P><F><P><L><A><L><L><G><W><A><P><S><N><I><T><F><A><L><L><F><G><R><R><F><D><Y><R><D><P><V><F><V><S><L><L><G><L><I><D><E><V><M><V><L><L><G><S><P><G><L><Q><L><F><N><V><Y><P><W><L><G><A><L><L><Q><L><H><R><P><V><L><R><K><I><E><E><V><R><A><I><L><R><T><L><L><E><A><R><R><P><H><V><C><P><G><D><P><V><C><S><Y><V><D><A><L><I><Q><Q><G><Q><G><D><D><P><E><G><L><F><A><E><A><N><A><V><A><C><T><L><D><M><V><M><A><G><T><E><T><T><S><A><T><L><Q><W><A><A><L><L><M><G><R><H><P><D><V><Q><G><R><V><Q><E><E><L><D><R><V><L><G><P><G><R><T><P><R><L><E><D><Q><Q><A><L><P><Y><T><S><A><V><L><H><E><V><Q><R><F><I><T><L><L><P><H><V><P><R><C><T><A><A><D><T><Q><L><G><G><F><L><L><P><K><G><T><P><V><I><P><L><L><T><S><V><L><L><D><E><T><Q><W><Q><T><P><G><Q><F><N><P><G><H><F><L><D><A><N><G><H><F><V><K><R><E><A><F><L><P><F><S><A><G><R><R><V><C><V><G><E><R><L><A><R><T><E><L><F><L><L><F><A><G><L><L><Q><R><Y><R><L><L><P><P><P><G><V><S><P><A><S><L><D><T><T><P><A><R><A><F><T><M><R><P><R><A><Q><A><L><C><A><V><P><R><P>
A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism . Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates . Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) . Has low or no activity toward 2-acylphospholipids/1-lysophospholip
Q8TAV3
P09960
LKHA4_HUMAN
Tripeptide aminopeptidase LTA4H
Homo
<M><P><E><I><V><D><T><C><S><L><A><S><P><A><S><V><C><R><T><K><H><L><H><L><R><C><S><V><D><F><T><R><R><T><L><T><G><T><A><A><L><T><V><Q><S><Q><E><D><N><L><R><S><L><V><L><D><T><K><D><L><T><I><E><K><V><V><I><N><G><Q><E><V><K><Y><A><L><G><E><R><Q><S><Y><K><G><S><P><M><E><I><S><L><P><I><A><L><S><K><N><Q><E><I><V><I><E><I><S><F><E><T><S><P><K><S><S><A><L><Q><W><L><T><P><E><Q><T><S><G><K><E><H><P><Y><L><F><S><Q><C><Q><A><I><H><C><R><A><I><L><P><C><Q><D><T><P><S><V><K><L><T><Y><T><A><E><V><S><V><P><K><E><L><V><A><L><M><S><A><I><R><D><G><E><T><P><D><P><E><D><P><S><R><K><I><Y><K><F><I><Q><K><V><P><I><P><C><Y><L><I><A><L><V><V><G><A><L><E><S><R><Q><I><G><P><R><T><L><V><W><S><E><K><E><Q><V><E><K><S><A><Y><E><F><S><E><T><E><S><M><L><K><I><A><E><D><L><G><G><P><Y><V><W><G><Q><Y><D><L><L><V><L><P><P><S><F><P><Y><G><G><M><E><N><P><C><L><T><F><V><T><P><T><L><L><A><G><D><K><S><L><S><N><V><I><A><H><E><I><S><H><S><W><T><G><N><L><V><T><N><K><T><W><D><H><F><W><L><N><E><G><H><T><V><Y><L><E><R><H><I><C><G><R><L><F><G><E><K><F><R><H><F><N><A><L><G><G><W><G><E><L><Q><N><S><V><K><T><F><G><E><T><H><P><F><T><K><L><V><V><D><L><T><D><I><D><P><D><V><A><Y><S><S><V><P><Y><E><K><G><F><A><L><L><F><Y><L><E><Q><L><L><G><G><P><E><I><F><L><G><F><L><K><A><Y><V><E><K><F><S><Y><K><S><I><T><T><D><D><W><K><D><F><L><Y><S><Y><F><K><D><K><V><D><V><L><N><Q><V><D><W><N><A><W><L><Y><S><P><G><L><P><P><I><K><P><N><Y><D><M><T><L><T><N><A><C><I><A><L><S><Q><R><W><I><T><A><K><E><D><D><L><N><S><F><N><A><T><D><L><K><D><L><S><S><H><Q><L><N><E><F><L><A><Q><T><L><Q><R><A><P><L><P><L><G><H><I><K><R><M><Q><E><V><Y><N><F><N><A><I><N><N><S><E><I><R><F><R><W><L><R><L><C><I><Q><S><K><W><E><D><A><I><P><L><A><L><K><M><A><T><E><Q><G><R><M><K><F><T><R><P><L><F><K><D><L><A><A><F><D><K><S><H><D><Q><A><V><R><T><Y><Q><E><H><K><A><S><M><H><P><V><T><A><M><L><V><G><K><D><L><K><V><D>
Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) . Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides . In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) . Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions .<BOP>
P09960
Q92565
RPGF5_HUMAN
Related to Epac
Homo
<M><G><S><S><R><L><R><V><F><D><P><H><L><E><R><K><D><S><A><A><A><L><S><D><R><E><L><P><L><P><T><F><D><V><P><Y><F><K><Y><I><D><E><E><D><E><D><D><E><W><S><S><R><S><Q><S><S><T><E><D><D><S><V><D><S><L><L><S><D><R><Y><V><V><V><S><G><T><P><E><K><I><L><E><H><L><L><N><D><L><H><L><E><E><V><Q><D><K><E><T><E><T><L><L><D><D><F><L><L><T><Y><T><V><F><M><T><T><D><D><L><C><Q><A><L><L><R><H><Y><S><A><K><K><Y><Q><G><K><E><E><N><S><D><V><P><R><R><K><R><K><V><L><H><L><V><S><Q><W><I><A><L><Y><K><D><W><L><P><E><D><E><H><S><K><M><F><L><K><T><I><Y><R><N><V><L><D><D><V><Y><E><Y><P><I><L><E><K><E><L><K><E><F><Q><K><I><L><G><M><H><R><R><H><T><V><D><E><Y><S><P><Q><K><K><N><K><A><L><F><H><Q><F><S><L><K><E><N><W><L><Q><H><R><G><T><V><T><E><T><E><E><I><F><C><H><V><Y><I><T><E><H><S><Y><V><S><V><K><A><K><V><S><S><I><A><Q><E><I><L><K><V><V><A><E><K><I><Q><Y><A><E><E><D><L><A><L><V><A><I><T><F><S><G><E><K><H><E><L><Q><P><N><D><L><V><I><S><K><S><L><E><A><S><G><R><I><Y><V><Y><R><K><D><L><A><D><T><L><N><P><F><A><E><N><E><E><S><Q><Q><R><S><M><R><I><L><G><M><N><T><W><D><L><A><L><E><L><M><N><F><D><W><S><L><F><N><S><I><H><E><Q><E><L><I><Y><F><T><F><S><R><Q><G><S><G><E><H><T><A><N><L><S><L><L><L><Q><R><C><N><E><V><Q><L><W><V><A><T><E><I><L><L><C><S><Q><L><G><K><R><V><Q><L><V><K><K><F><I><K><I><A><A><H><C><K><A><Q><R><N><L><N><S><F><F><A><I><V><M><G><L><N><T><A><S><V><S><R><L><S><Q><T><W><E><K><I><P><G><K><F><K><K><L><F><S><E><L><E><S><L><T><D><P><S><L><N><H><K><A><Y><R><D><A><F><K><K><M><K><P><P><K><I><P><F><M><P><L><L><L><K><D><V><T><F><I><H><E><G><N><K><T><F><L><D><N><L><V><N><F><E><K><L><H><M><I><A><D><T><V><R><T><L><R><H><C><R><T><N><Q><F><G><D><L><S><P><K><E><H><Q><E><L><K><S><Y><V><N><H><L><Y><V><I><D><S><Q><Q><A><L><F><E><L><S><H><R><I><E><P><R><V>
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.<BOP>
Q92565
Q9Y573
IPP_HUMAN
Kelch-like protein 27
Homo
<M><A><N><E><D><C><P><K><A><A><D><S><P><F><S><S><D><K><H><A><Q><L><I><L><A><Q><I><N><K><M><R><N><G><Q><H><F><C><D><V><Q><L><Q><V><G><Q><E><S><F><K><A><H><R><L><V><L><A><A><S><S><P><Y><F><A><A><L><F><T><G><G><M><K><E><S><S><K><D><V><V><P><I><L><G><I><E><A><G><I><F><Q><I><L><L><D><F><I><Y><T><G><I><V><N><I><G><V><N><N><V><Q><E><L><I><I><A><A><D><M><L><Q><L><T><E><V><V><H><L><C><C><E><F><L><K><G><Q><I><D><P><L><N><C><I><G><I><F><Q><F><S><E><Q><I><A><C><H><D><L><L><E><F><S><E><N><Y><I><H><V><H><F><L><E><V><H><S><G><E><E><F><L><A><L><T><K><D><Q><L><I><K><I><L><R><S><E><E><L><S><I><E><D><E><Y><Q><V><F><L><A><A><M><Q><W><I><L><K><D><L><G><K><R><R><K><H><V><V><E><V><L><D><P><I><R><F><P><L><L><P><P><Q><R><L><L><K><Y><I><E><G><V><S><D><F><N><L><R><V><A><L><Q><T><L><L><K><E><Y><C><E><V><C><K><S><P><K><E><N><K><F><C><S><F><L><Q><T><S><K><V><R><P><R><K><K><A><R><K><Y><L><Y><A><V><G><G><Y><T><R><L><Q><G><G><R><W><S><D><S><R><A><L><S><C><V><E><R><F><D><T><F><S><Q><Y><W><T><T><V><S><S><L><H><Q><A><R><S><G><L><G><V><T><V><L><G><G><M><V><Y><A><I><G><G><E><K><D><S><M><I><F><D><C><T><E><C><Y><D><P><V><T><K><Q><W><T><T><V><A><S><M><N><H><P><R><C><G><L><G><V><C><V><C><Y><G><A><I><Y><A><L><G><G><W><V><G><A><E><I><G><N><T><I><E><R><F><D><P><D><E><N><K><W><E><V><V><G><N><M><A><V><S><R><Y><Y><F><G><C><C><E><M><Q><G><L><I><Y><V><I><G><G><I><S><N><E><G><I><E><L><R><S><F><E><V><Y><D><P><L><S><K><R><W><S><P><L><P><P><M><G><T><R><R><A><Y><L><G><V><A><A><L><N><D><C><I><Y><S><V><G><G><W><N><E><T><Q><D><A><L><H><T><V><E><K><Y><S><F><E><E><E><K><W><V><E><V><A><S><M><K><V><P><R><A><G><M><C><V><V><A><V><N><G><L><L><Y><V><S><G><G><R><S><S><S><H><D><F><L><A><P><G><T><L><D><S><V><E><V><Y><N><P><H><S><D><T><W><T><E><I><G><N><M><I><T><S><R><C><E><G><G><V><A><V><L>
May play a role in organizing the actin cytoskeleton.<BOP>
Q9Y573
P58004
SESN2_HUMAN
Hypoxia-induced gene
Homo
<M><I><V><A><D><S><E><C><R><A><E><L><K><D><Y><L><R><F><A><P><G><G><V><G><D><S><G><P><G><E><E><Q><R><E><S><R><A><R><R><G><P><R><G><P><S><A><F><I><P><V><E><E><V><L><R><E><G><A><E><S><L><E><Q><H><L><G><L><E><A><L><M><S><S><G><R><V><D><N><L><A><V><V><M><G><L><H><P><D><Y><F><T><S><F><W><R><L><H><Y><L><L><L><H><T><D><G><P><L><A><S><S><W><R><H><Y><I><A><I><M><A><A><A><R><H><Q><C><S><Y><L><V><G><S><H><M><A><E><F><L><Q><T><G><G><D><P><E><W><L><L><G><L><H><R><A><P><E><K><L><R><K><L><S><E><I><N><K><L><L><A><H><R><P><W><L><I><T><K><E><H><I><Q><A><L><L><K><T><G><E><H><T><W><S><L><A><E><L><I><Q><A><L><V><L><L><T><H><C><H><S><L><S><S><F><V><F><G><C><G><I><L><P><E><G><D><A><D><G><S><P><A><P><Q><A><P><T><P><P><S><E><Q><S><S><P><P><S><R><D><P><L><N><N><S><G><G><F><E><S><A><R><D><V><E><A><L><M><E><R><M><Q><Q><L><Q><E><S><L><L><R><D><E><G><T><S><Q><E><E><M><E><S><R><F><E><L><E><K><S><E><S><L><L><V><T><P><S><A><D><I><L><E><P><S><P><H><P><D><M><L><C><F><V><E><D><P><T><F><G><Y><E><D><F><T><R><R><G><A><Q><A><P><P><T><F><R><A><Q><D><Y><T><W><E><D><H><G><Y><S><L><I><Q><R><L><Y><P><E><G><G><Q><L><L><D><E><K><F><Q><A><A><Y><S><L><T><Y><N><T><I><A><M><H><S><G><V><D><T><S><V><L><R><R><A><I><W><N><Y><I><H><C><V><F><G><I><R><Y><D><D><Y><D><Y><G><E><V><N><Q><L><L><E><R><N><L><K><V><Y><I><K><T><V><A><C><Y><P><E><K><T><T><R><R><M><Y><N><L><F><W><R><H><F><R><H><S><E><K><V><H><V><N><L><L><L><L><E><A><R><M><Q><A><A><L><L><Y><A><L><R><A><I><T><R><Y><M><T>
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex . In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway . This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 . May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress . Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 . However, this could not be confirmed .<BOP>
P58004
Q6UVJ0
SAS6_HUMAN
Spindle assembly abnormal protein 6 homolog
Homo
<M><S><Q><V><L><F><H><Q><L><V><P><L><Q><V><K><C><K><D><C><E><E><R><R><V><S><I><R><M><S><I><E><L><Q><S><V><S><N><P><V><H><R><K><D><L><V><I><R><L><T><D><D><T><D><P><F><F><L><Y><N><L><V><I><S><E><E><D><F><Q><S><L><K><F><Q><Q><G><L><L><V><D><F><L><A><F><P><Q><K><F><I><D><L><L><Q><Q><C><T><Q><E><H><A><K><E><I><P><R><F><L><L><Q><L><V><S><P><A><A><I><L><D><N><S><P><A><F><L><N><V><V><E><T><N><P><F><K><H><L><T><H><L><S><L><K><L><L><P><G><N><D><V><E><I><K><K><F><L><A><G><C><L><K><C><S><K><E><E><K><L><S><L><M><Q><S><L><D><D><A><T><K><Q><L><D><F><T><R><K><T><L><A><E><K><K><Q><E><L><D><K><L><R><N><E><W><A><S><H><T><A><A><L><T><N><K><H><S><Q><E><L><T><N><E><K><E><K><A><L><Q><A><Q><V><Q><Y><Q><Q><Q><H><E><Q><Q><K><K><D><L><E><I><L><H><Q><Q><N><I><H><Q><L><Q><N><R><L><S><E><L><E><A><A><N><K><D><L><T><E><R><K><Y><K><G><D><S><T><I><R><E><L><K><A><K><L><S><G><V><E><E><E><L><Q><R><T><K><Q><E><V><L><S><L><R><R><E><N><S><T><L><D><V><E><C><H><E><K><E><K><H><V><N><Q><L><Q><T><K><V><A><V><L><E><Q><E><I><K><D><K><D><Q><L><V><L><R><T><K><E><A><F><D><T><I><Q><E><Q><K><V><V><L><E><E><N><G><E><K><N><Q><V><Q><L><G><K><L><E><A><T><I><K><S><L><S><A><E><L><L><K><A><N><E><I><I><K><K><L><Q><G><D><L><K><T><L><M><G><K><L><K><L><K><N><T><V><T><I><Q><Q><E><K><L><L><A><E><K><E><E><K><L><Q><K><E><Q><K><E><L><Q><D><V><G><Q><S><L><R><I><K><E><Q><E><V><C><K><L><Q><E><Q><L><E><A><T><V><K><K><L><E><E><S><K><Q><L><L><K><N><N><E><K><L><I><T><W><L><N><K><E><L><N><E><N><Q><L><V><R><K><Q><D><V><L><G><P><S><T><T><P><P><A><H><S><S><S><N><T><I><R><S><G><I><S><P><N><L><N><V><V><D><G><R><L><T><Y><P><T><C><G><I><G><Y><P><V><S><S><A><F><A><F><Q><N><T><F><P><H><S><I><S><A><K><N><T><S><H><P><G><S><G><T><K><V><Q><F><N><L><Q><F><T><K><P><N><A><S><L><G><D><V><Q><S><G><A><T><I><S><M><P><C><S><T><D><K><E><N><G><E><N><V><G><L><E><S><K><Y><L><K><K><R><E><D><S><I><P><L><R><G><L><S><Q><N><L><F><S><N><S><D><H><Q><R><D><G><T><L><G><A><L><H><T><S><S><K><P><T><A><L><P><S><A><S><S><A><Y><F><P><G><Q><L><P><N><S>
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification .<BOP>
Q6UVJ0
Q8NCT3
MACA2_HUMAN
Putative tyrosine carboxypeptidase MATCAP2
Homo
<M><A><G><C><T><R><K><L><T><H><L><R><K><R><I><H><R><P><R><R><R><T><T><R><R><W><K><R><W><F><K><F><R><K><R><K><G><E><K><R><P><R><P><N><H><K><A><V><A><R><R><A><K><L><K><F><S><T><S><E><K><L><H><W><P><E><Q><E><L><A><K><K><S><I><L><N><A><E><D><S><L><I><I><D><N><K><R><S><I><S><H><L><S><S><G><V><L><K><D><I><F><T><T><G><T><S><S><Y><N><V><L><L><Q><S><K><E><E><K><K><Y><H><S><Q><K><Q><S><S><S><T><Y><S><K><R><C><R><K><P><S><K><S><P><N><T><S><R><S><K><D><P><R><R><M><K><A><L><V><P><V><T><S><S><G><T><W><Y><C><L><E><R><R><P><A><V><F><V><T><S><S><V><S><S><P><V><K><F><T><H><D><I><S><V><T><G><N><G><I><V><L><P><P><K><P><K><S><K><V><K><W><C><H><F><S><T><L><P><K><P><K><P><Q><L><S><R><S><F><E><K><G><D><D><F><S><G><K><K><F><C><I><L><T><A><I><K><P><T><N><L><E><K><E><K><L><R><F><F><K><S><D><Y><T><Y><N><P><Q><F><E><Y><A><N><P><A><L><P><S><V><L><A><K><H><S><H><A><S><D><R><F><L><K><Q><I><V><V><H><L><T><E><D><L><L><S><R><A><S><M><T><V><V><N><G><C><P><T><L><T><I><N><V><S><T><A><R><E><H><W><L><E><G><M><L><R><H><E><I><G><T><H><Y><F><R><G><I><N><N><L><Q><Q><P><W><N><S><W><T><G><R><K><K><H><E><L><K><P><N><N><P><T><E><E><G><L><A><S><I><H><S><V><L><F><R><K><D><P><F><L><W><R><A><A><L><L><Y><Y><T><V><Y><Q><A><S><Q><M><S><F><C><E><L><F><K><D><I><G><R><F><V><K><D><P><N><T><R><W><D><Y><C><V><R><A><K><R><G><W><T><D><T><S><Q><P><G><C><F><S><K><D><Q><V><Y><L><D><G><I><L><Q><I><L><R><Y><R><D><T><I><D><F><H><L><L><T><A><L><G><K><V><S><Y><E><D><V><D><R><L><K><G><L><A><V><T><E><N><M><R><V><P><H><F><L><Q><D><H><G><R><Y><M><E><H><L><E><K><I><M><E><V><N><E><L><T><D><R><E><L><K><D><L><I>
Putative tyrosine carboxypeptidase.<BOP>
Q8NCT3
Q8IUE1
TF2LX_HUMAN
TGIF-like on the X
Homo
<M><E><A><A><A><D><G><P><A><E><T><Q><S><P><V><E><K><D><S><P><A><K><T><Q><S><P><A><Q><D><T><S><I><M><S><R><N><N><A><D><T><G><R><V><L><A><L><P><E><H><K><K><K><R><K><G><N><L><P><A><E><S><V><K><I><L><R><D><W><M><Y><K><H><R><F><K><A><Y><P><S><E><E><E><K><Q><M><L><S><E><K><T><N><L><S><L><L><Q><I><S><N><W><F><I><N><A><R><R><R><I><L><P><D><M><L><Q><Q><R><R><N><D><P><I><I><G><H><K><T><G><K><D><A><H><A><T><H><L><Q><S><T><E><A><S><V><P><A><K><S><G><P><S><G><P><D><N><V><Q><S><L><P><L><W><P><L><P><K><G><Q><M><S><R><E><K><Q><P><D><P><E><S><A><P><S><Q><K><L><T><G><I><A><Q><P><K><K><K><V><K><V><S><V><T><S><P><S><S><P><E><L><V><S><P><E><E><H><A><D><F><S><S><F><L><L><L><V><D><A><A><V><Q><R><A><A><E><L><E><L><E><K><K><Q><E><P><N><P>
May have a transcription role in testis.<BOP>
Q8IUE1
P03956
MMP1_HUMAN
27 kDa interstitial collagenase
Homo
<M><H><S><F><P><P><L><L><L><L><L><F><W><G><V><V><S><H><S><F><P><A><T><L><E><T><Q><E><Q><D><V><D><L><V><Q><K><Y><L><E><K><Y><Y><N><L><K><N><D><G><R><Q><V><E><K><R><R><N><S><G><P><V><V><E><K><L><K><Q><M><Q><E><F><F><G><L><K><V><T><G><K><P><D><A><E><T><L><K><V><M><K><Q><P><R><C><G><V><P><D><V><A><Q><F><V><L><T><E><G><N><P><R><W><E><Q><T><H><L><T><Y><R><I><E><N><Y><T><P><D><L><P><R><A><D><V><D><H><A><I><E><K><A><F><Q><L><W><S><N><V><T><P><L><T><F><T><K><V><S><E><G><Q><A><D><I><M><I><S><F><V><R><G><D><H><R><D><N><S><P><F><D><G><P><G><G><N><L><A><H><A><F><Q><P><G><P><G><I><G><G><D><A><H><F><D><E><D><E><R><W><T><N><N><F><R><E><Y><N><L><H><R><V><A><A><H><E><L><G><H><S><L><G><L><S><H><S><T><D><I><G><A><L><M><Y><P><S><Y><T><F><S><G><D><V><Q><L><A><Q><D><D><I><D><G><I><Q><A><I><Y><G><R><S><Q><N><P><V><Q><P><I><G><P><Q><T><P><K><A><C><D><S><K><L><T><F><D><A><I><T><T><I><R><G><E><V><M><F><F><K><D><R><F><Y><M><R><T><N><P><F><Y><P><E><V><E><L><N><F><I><S><V><F><W><P><Q><L><P><N><G><L><E><A><A><Y><E><F><A><D><R><D><E><V><R><F><F><K><G><N><K><Y><W><A><V><Q><G><Q><N><V><L><H><G><Y><P><K><D><I><Y><S><S><F><G><F><P><R><T><V><K><H><I><D><A><A><L><S><E><E><N><T><G><K><T><Y><F><F><V><A><N><K><Y><W><R><Y><D><E><Y><K><R><S><M><D><P><G><Y><P><K><M><I><A><H><D><F><P><G><I><G><H><K><V><D><A><V><F><M><K><D><G><F><F><Y><F><F><H><G><T><R><Q><Y><K><F><D><P><K><T><K><R><I><L><T><L><Q><K><A><N><S><W><F><N><C><R><K><N>
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X . In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity .<BOP>
P03956
O75462
CRLF1_HUMAN
ZcytoR5
Homo
<M><P><A><G><R><R><G><P><A><A><Q><S><A><R><R><P><P><P><L><L><P><L><L><L><L><L><C><V><L><G><A><P><R><A><G><S><G><A><H><T><A><V><I><S><P><Q><D><P><T><L><L><I><G><S><S><L><L><A><T><C><S><V><H><G><D><P><P><G><A><T><A><E><G><L><Y><W><T><L><N><G><R><R><L><P><P><E><L><S><R><V><L><N><A><S><T><L><A><L><A><L><A><N><L><N><G><S><R><Q><R><S><G><D><N><L><V><C><H><A><R><D><G><S><I><L><A><G><S><C><L><Y><V><G><L><P><P><E><K><P><V><N><I><S><C><W><S><K><N><M><K><D><L><T><C><R><W><T><P><G><A><H><G><E><T><F><L><H><T><N><Y><S><L><K><Y><K><L><R><W><Y><G><Q><D><N><T><C><E><E><Y><H><T><V><G><P><H><S><C><H><I><P><K><D><L><A><L><F><T><P><Y><E><I><W><V><E><A><T><N><R><L><G><S><A><R><S><D><V><L><T><L><D><I><L><D><V><V><T><T><D><P><P><P><D><V><H><V><S><R><V><G><G><L><E><D><Q><L><S><V><R><W><V><S><P><P><A><L><K><D><F><L><F><Q><A><K><Y><Q><I><R><Y><R><V><E><D><S><V><D><W><K><V><V><D><D><V><S><N><Q><T><S><C><R><L><A><G><L><K><P><G><T><V><Y><F><V><Q><V><R><C><N><P><F><G><I><Y><G><S><K><K><A><G><I><W><S><E><W><S><H><P><T><A><A><S><T><P><R><S><E><R><P><G><P><G><G><G><A><C><E><P><R><G><G><E><P><S><S><G><P><V><R><R><E><L><K><Q><F><L><G><W><L><K><K><H><A><Y><C><S><N><L><S><F><R><L><Y><D><Q><W><R><A><W><M><Q><K><S><H><K><T><R><N><Q><D><E><G><I><L><P><S><G><R><R><G><T><A><R><G><P><A><R>
In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.<BOP>
O75462
A0A075B6S0
TRGJ1_HUMAN
T cell receptor gamma joining 1
Homo
<N><Y><Y><K><K><L><F><G><S><G><T><T><L><V><V><T>
J region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential
A0A075B6S0
Q9BY21
GPR87_HUMAN
G-protein coupled receptor 95
Homo
<M><G><F><N><L><T><L><A><K><L><P><N><N><E><L><H><G><Q><E><S><H><N><S><G><N><R><S><D><G><P><G><K><N><T><T><L><H><N><E><F><D><T><I><V><L><P><V><L><Y><L><I><I><F><V><A><S><I><L><L><N><G><L><A><V><W><I><F><F><H><I><R><N><K><T><S><F><I><F><Y><L><K><N><I><V><V><A><D><L><I><M><T><L><T><F><P><F><R><I><V><H><D><A><G><F><G><P><W><Y><F><K><F><I><L><C><R><Y><T><S><V><L><F><Y><A><N><M><Y><T><S><I><V><F><L><G><L><I><S><I><D><R><Y><L><K><V><V><K><P><F><G><D><S><R><M><Y><S><I><T><F><T><K><V><L><S><V><C><V><W><V><I><M><A><V><L><S><L><P><N><I><I><L><T><N><G><Q><P><T><E><D><N><I><H><D><C><S><K><L><K><S><P><L><G><V><K><W><H><T><A><V><T><Y><V><N><S><C><L><F><V><A><V><L><V><I><L><I><G><C><Y><I><A><I><S><R><Y><I><H><K><S><S><R><Q><F><I><S><Q><S><S><R><K><R><K><H><N><Q><S><I><R><V><V><V><A><V><F><F><T><C><F><L><P><Y><H><L><C><R><I><P><F><T><F><S><H><L><D><R><L><L><D><E><S><A><Q><K><I><L><Y><Y><C><K><E><I><T><L><F><L><S><A><C><N><V><C><L><D><P><I><I><Y><F><F><M><C><R><S><F><S><R><R><L><F><K><K><S><N><I><R><T><R><S><E><S><I><R><S><L><Q><S><V><R><R><S><E><V><R><I><Y><Y><D><Y><T><D><V>
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.<BOP>
Q9BY21
Q9H707
ZN552_HUMAN
Zinc finger protein 552
Homo
<M><A><A><A><A><L><R><F><P><V><Q><G><T><V><T><F><E><D><V><A><V><K><F><T><Q><E><E><W><N><L><L><S><E><A><Q><R><C><L><Y><R><D><V><T><L><E><N><L><A><L><M><S><S><L><G><C><W><C><G><V><E><D><E><A><A><P><S><K><Q><S><I><Y><I><Q><R><E><T><Q><V><R><T><P><M><A><G><V><S><P><K><K><A><H><P><C><E><M><C><G><P><I><L><G><D><I><L><H><V><A><D><H><Q><G><T><H><H><K><Q><K><L><H><R><C><E><A><W><G><N><K><L><Y><D><S><G><N><F><H><Q><H><Q><N><E><H><I><G><E><K><P><Y><R><G><S><V><E><E><A><L><F><A><K><R><C><K><L><H><V><S><G><E><S><S><V><F><S><E><S><G><K><D><F><L><L><R><S><G><L><L><Q><Q><E><A><T><H><T><G><K><S><N><S><K><T><E><C><V><S><L><F><H><G><G><K><S><H><Y><S><C><G><G><C><M><K><H><F><S><T><K><D><I><L><S><Q><H><E><R><L><L><P><T><E><E><P><S><V><W><C><E><C><G><K><S><S><S><K><Y><D><S><F><S><N><H><Q><G><V><H><T><R><E><K><P><Y><T><C><G><I><C><G><K><L><F><N><S><K><S><H><L><L><V><H><Q><R><I><H><T><G><E><K><P><Y><E><C><E><V><C><Q><K><F><F><R><H><K><Y><H><L><I><A><H><Q><R><V><H><T><G><E><R><P><Y><E><C><S><D><C><G><K><S><F><T><H><S><S><T><F><R><V><H><K><R><V><H><T><G><Q><K><P><Y><E><C><S><E><C><G><K><S><F><A><E><S><S><S><L><T><K><H><R><R><V><H><T><G><E><K><P><Y><G><C><S><E><C><E><K><K><F><R><Q><I><S><S><L><R><H><H><Q><R><V><H><K><R><K><G><L>
May be involved in transcriptional regulation.<BOP>
Q9H707
P47992
XCL1_HUMAN
XC chemokine ligand 1
Homo
<M><R><L><L><I><L><A><L><L><G><I><C><S><L><T><A><Y><I><V><E><G><V><G><S><E><V><S><D><K><R><T><C><V><S><L><T><T><Q><R><L><P><V><S><R><I><K><T><Y><T><I><T><E><G><S><L><R><A><V><I><F><I><T><K><R><G><L><K><V><C><A><D><P><Q><A><T><W><V><R><D><V><V><R><S><M><D><R><K><S><N><T><R><N><N><M><I><Q><T><K><P><T><G><T><Q><Q><S><T><N><T><A><V><T><L><T><G>
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.<BOP>
P47992
Q01546
K22O_HUMAN
Type-II keratin Kb9
Homo
<M><N><R><Q><V><C><K><K><S><F><S><G><R><S><Q><G><F><S><G><R><S><A><V><V><S><G><S><S><R><M><S><C><V><A><R><S><G><G><A><G><G><G><A><C><G><F><R><S><G><A><G><S><F><G><S><R><S><L><Y><N><L><G><S><N><K><S><I><S><I><S><V><A><A><G><S><S><R><A><G><G><F><G><G><G><R><S><S><C><G><F><A><G><G><Y><G><G><G><F><G><G><S><Y><G><G><G><F><G><G><G><R><G><V><G><S><G><F><G><G><A><G><G><F><G><G><A><G><G><F><G><G><P><G><V><F><G><G><P><G><S><F><G><G><P><G><G><F><G><P><G><G><F><P><G><G><I><Q><E><V><I><V><N><Q><S><L><L><Q><P><L><N><V><E><I><D><P><Q><I><G><Q><V><K><A><Q><E><R><E><Q><I><K><T><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><K><V><L><E><T><K><W><E><L><L><Q><Q><Q><T><T><G><S><G><P><S><S><L><E><P><C><F><E><S><Y><I><S><F><L><C><K><Q><L><D><S><L><L><G><E><R><G><N><L><E><G><E><L><K><S><M><Q><D><L><V><E><D><F><K><K><K><Y><E><D><E><I><N><K><R><T><A><A><E><N><E><F><V><G><L><K><K><D><V><D><A><A><F><M><N><K><V><E><L><Q><A><K><V><D><S><L><T><D><E><V><S><F><L><R><T><L><Y><E><M><E><L><S><Q><M><Q><S><H><A><S><D><T><S><V><V><L><S><M><D><N><N><R><C><L><D><L><G><S><I><I><A><E><V><R><A><Q><Y><E><E><I><A><Q><R><S><K><S><E><A><E><A><L><Y><Q><T><K><L><G><E><L><Q><T><T><A><G><R><H><G><D><D><L><R><N><T><K><S><E><I><M><E><L><N><R><M><I><Q><R><L><R><A><E><I><E><N><V><K><K><Q><N><A><N><L><Q><T><A><I><A><E><A><E><Q><R><G><E><M><A><L><K><D><A><N><A><K><L><Q><D><L><Q><T><A><L><Q><K><A><K><D><D><L><A><R><L><L><R><D><Y><Q><E><L><M><N><V><K><L><A><L><D><V><E><I><A><T><Y><R><K><L><L><E><G><E><E><C><R><M><S><G><E><C><Q><S><A><V><C><I><S><V><V><S><N><V><T><S><T><S><G><S><S><G><S><S><R><G><V><F><G><G><V><S><G><S><G><S><G><G><Y><K><G><G><S><S><S><S><S><S><S><G><Y><G><V><S><G><G><S><G><S><G><Y><G><G><V><S><S><G><S><T><G><G><R><G><S><S><G><S><Y><Q><S><S><S><S><G><S><R><L><G><G><A><G><S><I><S><V><S><H><S><G><M><G><S><S><S><G><S><I><Q><T><S><G><G><S><G><Y><K><S><G><G><G><G><S><T><S><I><R><F><S><Q><T><T><S><S><S><Q><H><S><S><T><K>
Probably contributes to terminal cornification.<BOP>
Q01546
Q9H5V9
STEEP_HUMAN
STING ER exit protein
Homo
<M><P><K><V><V><S><R><S><V><V><C><S><D><T><R><D><R><E><E><Y><D><D><G><E><K><P><L><H><V><Y><Y><C><L><C><G><Q><M><V><L><V><L><D><C><Q><L><E><K><L><P><M><R><P><R><D><R><S><R><V><I><D><A><A><K><H><A><H><K><F><C><N><T><E><D><E><E><T><M><Y><L><R><R><P><E><G><I><E><R><Q><Y><R><K><K><C><A><K><C><G><L><P><L><F><Y><Q><S><Q><P><K><N><A><P><V><T><F><I><V><D><G><A><V><V><K><F><G><Q><G><F><G><K><T><N><I><Y><T><Q><K><Q><E><P><P><K><K><V><M><M><T><K><R><T><K><D><M><G><K><F><S><S><V><T><V><S><T><I><D><E><E><E><E><E><I><E><A><R><E><V><A><D><S><Y><A><Q><N><A><K><V><I><E><K><Q><L><E><R><K><G><M><S><K><R><R><L><Q><E><L><A><E><L><E><A><K><K><A><K><M><K><G><T><L><I><D><N><Q><F><K>
Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport . Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers .<BOP>
Q9H5V9
Q9Y587
AP4S1_HUMAN
Sigma-4-adaptin
Homo
<M><I><K><F><F><L><M><V><N><K><Q><G><Q><T><R><L><S><K><Y><Y><E><H><V><D><I><N><K><R><T><L><L><E><T><E><V><I><K><S><C><L><S><R><S><N><E><Q><C><S><F><I><E><Y><K><D><F><K><L><I><Y><R><Q><Y><A><A><L><F><I><V><V><G><V><N><D><T><E><N><E><M><A><I><Y><E><F><I><H><N><F><V><E><V><L><D><E><Y><F><S><R><V><S><E><L><D><I><M><F><N><L><D><K><V><H><I><I><L><D><E><M><V><L><N><G><C><I><V><E><T><N><R><A><R><I><L><A><P><L><L><I><L><D><K><M><S><E><S>
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).<BOP>
Q9Y587
O15264
MK13_HUMAN
Stress-activated protein kinase 4
Homo
<M><S><L><I><R><K><K><G><F><Y><K><Q><D><V><N><K><T><A><W><E><L><P><K><T><Y><V><S><P><T><H><V><G><S><G><A><Y><G><S><V><C><S><A><I><D><K><R><S><G><E><K><V><A><I><K><K><L><S><R><P><F><Q><S><E><I><F><A><K><R><A><Y><R><E><L><L><L><L><K><H><M><Q><H><E><N><V><I><G><L><L><D><V><F><T><P><A><S><S><L><R><N><F><Y><D><F><Y><L><V><M><P><F><M><Q><T><D><L><Q><K><I><M><G><M><E><F><S><E><E><K><I><Q><Y><L><V><Y><Q><M><L><K><G><L><K><Y><I><H><S><A><G><V><V><H><R><D><L><K><P><G><N><L><A><V><N><E><D><C><E><L><K><I><L><D><F><G><L><A><R><H><A><D><A><E><M><T><G><Y><V><V><T><R><W><Y><R><A><P><E><V><I><L><S><W><M><H><Y><N><Q><T><V><D><I><W><S><V><G><C><I><M><A><E><M><L><T><G><K><T><L><F><K><G><K><D><Y><L><D><Q><L><T><Q><I><L><K><V><T><G><V><P><G><T><E><F><V><Q><K><L><N><D><K><A><A><K><S><Y><I><Q><S><L><P><Q><T><P><R><K><D><F><T><Q><L><F><P><R><A><S><P><Q><A><A><D><L><L><E><K><M><L><E><L><D><V><D><K><R><L><T><A><A><Q><A><L><T><H><P><F><F><E><P><F><R><D><P><E><E><E><T><E><A><Q><Q><P><F><D><D><S><L><E><H><E><K><L><T><V><D><E><W><K><Q><H><I><Y><K><E><I><V><N><F><S><P><I><A><R><K><D><S><R><R><R><S><G><M><K><L>
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB
O15264
P04839
CY24B_HUMAN
p22 phagocyte B-cytochrome
Homo
<M><G><N><W><A><V><N><E><G><L><S><I><F><V><I><L><V><W><L><G><L><N><V><F><L><F><V><W><Y><Y><R><V><Y><D><I><P><P><K><F><F><Y><T><R><K><L><L><G><S><A><L><A><L><A><R><A><P><A><A><C><L><N><F><N><C><M><L><I><L><L><P><V><C><R><N><L><L><S><F><L><R><G><S><S><A><C><C><S><T><R><V><R><R><Q><L><D><R><N><L><T><F><H><K><M><V><A><W><M><I><A><L><H><S><A><I><H><T><I><A><H><L><F><N><V><E><W><C><V><N><A><R><V><N><N><S><D><P><Y><S><V><A><L><S><E><L><G><D><R><Q><N><E><S><Y><L><N><F><A><R><K><R><I><K><N><P><E><G><G><L><Y><L><A><V><T><L><L><A><G><I><T><G><V><V><I><T><L><C><L><I><L><I><I><T><S><S><T><K><T><I><R><R><S><Y><F><E><V><F><W><Y><T><H><H><L><F><V><I><F><F><I><G><L><A><I><H><G><A><E><R><I><V><R><G><Q><T><A><E><S><L><A><V><H><N><I><T><V><C><E><Q><K><I><S><E><W><G><K><I><K><E><C><P><I><P><Q><F><A><G><N><P><P><M><T><W><K><W><I><V><G><P><M><F><L><Y><L><C><E><R><L><V><R><F><W><R><S><Q><Q><K><V><V><I><T><K><V><V><T><H><P><F><K><T><I><E><L><Q><M><K><K><K><G><F><K><M><E><V><G><Q><Y><I><F><V><K><C><P><K><V><S><K><L><E><W><H><P><F><T><L><T><S><A><P><E><E><D><F><F><S><I><H><I><R><I><V><G><D><W><T><E><G><L><F><N><A><C><G><C><D><K><Q><E><F><Q><D><A><W><K><L><P><K><I><A><V><D><G><P><F><G><T><A><S><E><D><V><F><S><Y><E><V><V><M><L><V><G><A><G><I><G><V><T><P><F><A><S><I><L><K><S><V><W><Y><K><Y><C><N><N><A><T><N><L><K><L><K><K><I><Y><F><Y><W><L><C><R><D><T><H><A><F><E><W><F><A><D><L><L><Q><L><L><E><S><Q><M><Q><E><R><N><N><A><G><F><L><S><Y><N><I><Y><L><T><G><W><D><E><S><Q><A><N><H><F><A><V><H><H><D><E><E><K><D><V><I><T><G><L><K><Q><K><T><L><Y><G><R><P><N><W><D><N><E><F><K><T><I><A><S><Q><H><P><N><T><R><I><G><V><F><L><C><G><P><E><A><L><A><E><T><L><S><K><Q><S><I><S><N><S><E><S><G><P><R><G><V><H><F><I><F><N><K><E><N><F>
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.<BOP>
P04839
Q9BUM1
G6PC3_HUMAN
Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Homo
<M><E><S><T><L><G><A><G><I><V><I><A><E><A><L><Q><N><Q><L><A><W><L><E><N><V><W><L><W><I><T><F><L><G><D><P><K><I><L><F><L><F><Y><F><P><A><A><Y><Y><A><S><R><R><V><G><I><A><V><L><W><I><S><L><I><T><E><W><L><N><L><I><F><K><W><F><L><F><G><D><R><P><F><W><W><V><H><E><S><G><Y><Y><S><Q><A><P><A><Q><V><H><Q><F><P><S><S><C><E><T><G><P><G><S><P><S><G><H><C><M><I><T><G><A><A><L><W><P><I><M><T><A><L><S><S><Q><V><A><T><R><A><R><S><R><W><V><R><V><M><P><S><L><A><Y><C><T><F><L><L><A><V><G><L><S><R><I><F><I><L><A><H><F><P><H><Q><V><L><A><G><L><I><T><G><A><V><L><G><W><L><M><T><P><R><V><P><M><E><R><E><L><S><F><Y><G><L><T><A><L><A><L><M><L><G><T><S><L><I><Y><W><T><L><F><T><L><G><L><D><L><S><W><S><I><S><L><A><F><K><W><C><E><R><P><E><W><I><H><V><D><S><R><P><F><A><S><L><S><R><D><S><G><A><A><L><G><L><G><I><A><L><H><S><P><C><Y><A><Q><V><R><R><A><Q><L><G><N><G><Q><K><I><A><C><L><V><L><A><M><G><L><L><G><P><L><D><W><L><G><H><P><P><Q><I><S><L><F><Y><I><F><N><F><L><K><Y><T><L><W><P><C><L><V><L><A><L><V><P><W><A><V><H><M><F><S><A><Q><E><A><P><P><I><H><S><S>
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.<BOP>
Q9BUM1
P28360
MSX1_HUMAN
Msh homeobox 1-like protein
Homo
<M><A><P><A><A><D><M><T><S><L><P><L><G><V><K><V><E><D><S><A><F><G><K><P><A><G><G><G><A><G><Q><A><P><S><A><A><A><A><T><A><A><A><M><G><A><D><E><E><G><A><K><P><K><V><S><P><S><L><L><P><F><S><V><E><A><L><M><A><D><H><R><K><P><G><A><K><E><S><A><L><A><P><S><E><G><V><Q><A><A><G><G><S><A><Q><P><L><G><V><P><P><G><S><L><G><A><P><D><A><P><S><S><P><R><P><L><G><H><F><S><V><G><G><L><L><K><L><P><E><D><A><L><V><K><A><E><S><P><E><K><P><E><R><T><P><W><M><Q><S><P><R><F><S><P><P><P><A><R><R><L><S><P><P><A><C><T><L><R><K><H><K><T><N><R><K><P><R><T><P><F><T><T><A><Q><L><L><A><L><E><R><K><F><R><Q><K><Q><Y><L><S><I><A><E><R><A><E><F><S><S><S><L><S><L><T><E><T><Q><V><K><I><W><F><Q><N><R><R><A><K><A><K><R><L><Q><E><A><E><L><E><K><L><K><M><A><A><K><P><M><L><P><P><A><A><F><G><L><S><F><P><L><G><G><P><A><A><V><A><A><A><A><G><A><S><L><Y><G><A><S><G><P><F><Q><R><A><A><L><P><V><A><P><V><G><L><Y><T><A><H><V><G><Y><S><M><Y><H><L><T>
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.<BOP>
P28360
A8K855
EFCB7_HUMAN
EF-hand calcium-binding domain-containing protein 7
Homo
<M><A><I><S><P><R><S><D><A><T><F><S><S><Q><K><S><T><P><S><E><S><P><R><T><K><K><F><P><L><T><E><E><E><I><F><Y><M><N><C><R><A><A><Y><L><T><V><F><K><S><S><L><E><N><I><I><S><K><D><Q><L><Y><L><A><L><Q><H><A><G><R><N><P><S><Q><K><T><I><N><K><Y><W><T><P><Q><T><A><K><L><N><F><D><D><F><C><I><I><L><R><K><E><K><P><T><S><K><A><E><L><L><K><S><F><K><Q><L><D><V><N><D><D><G><C><I><L><H><T><D><L><Y><K><F><L><T><K><R><G><E><K><M><T><R><E><E><V><N><A><I><I><N><L><A><D><V><N><A><D><G><K><F><D><Y><I><K><F><C><K><L><Y><M><T><T><N><E><Q><C><L><K><T><T><L><E><K><L><E><V><D><S><K><L><M><R><H><Q><F><G><N><H><I><E><G><S><P><E><R><D><P><S><P><V><P><K><P><S><P><K><I><T><R><K><T><D><P><E><T><F><L><N><K><G><D><T><R><S><S><L><L><S><A><T><R><K><F><K><T><S><V><S><F><T><V><T><M><G><A><N><G><N><R><N><S><K><L><M><E><P><N><L><I><K><D><W><Q><H><M><Q><S><K><G><C><F><F><L><E><E><D><G><E><I><I><S><H><Q><Y><R><M><Q><I><A><Q><R><S><M><V><Y><L><T><I><K><P><L><N><L><S><Q><V><E><G><K><P><S><P><W><L><S><V><D><T><A><L><Y><I><L><K><E><N><E><S><Q><A><N><L><Q><L><V><C><F><T><E><L><R><N><R><E><V><F><G><W><T><G><E><L><G><P><G><I><Y><W><L><I><P><S><T><T><G><C><R><L><R><K><K><I><K><P><V><T><D><E><A><Q><L><V><Y><R><D><E><T><G><E><L><F><L><T><K><E><F><K><S><T><L><S><D><I><F><E><V><I><D><L><D><G><N><G><L><L><S><L><E><E><Y><N><F><F><E><L><R><T><S><G><E><K><C><D><E><D><A><W><A><V><C><R><E><N><F><D><T><K><R><N><E><L><T><R><Q><G><F><M><D><L><N><L><M><E><A><N><D><R><E><G><D><P><C><D><L><W><V><T><L><H><S><M><G><Y><N><K><A><L><E><L><T><E><A><C><P><F><V><I><D><I><Y><A><E><K><C><K><P><K><I><K><A><V><H><M><E><A><C><S><G><Q><L><E><K><A><I><C><K><S><V><L><S><N><G><D><A><K><V><M><D><G><Y><E><N><I><I><V><H><T><Y><S><C><D><T><W><I><T><S><V><I><E><N><K><S><D><E><K><V><I><I><H><I><S><N><E><L><S><K><N><C><I><N><N><R><G><L><N><I><F><A><V><E><V><G><P><K><S><T><M><V><C><Q><H><V><M><P><L><N><E><R><Q><E><W><I><Y><Y><C><I><Y><S><L><I><S>
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.<BOP>
A8K855
Q8TAP9
MPLKI_HUMAN
TTD non-photosensitive 1 protein
Homo
<M><Q><R><Q><N><F><R><P><P><T><P><P><Y><P><G><P><G><G><G><G><W><G><S><G><S><S><F><R><G><T><P><G><G><G><G><P><R><P><P><S><P><R><D><G><Y><G><S><P><H><H><T><P><P><Y><G><P><R><S><R><P><Y><G><S><S><H><S><P><R><H><G><G><S><F><P><G><G><R><F><G><S><P><S><P><G><G><Y><P><G><S><Y><S><R><S><P><A><G><S><Q><Q><Q><F><G><Y><S><P><G><Q><Q><Q><T><H><P><Q><G><S><P><R><T><S><T><P><F><G><S><G><R><V><R><E><K><R><M><S><N><E><L><E><N><Y><F><K><P><S><M><L><E><D><P><W><A><G><L><E><P><V><S><V><V><D><I><S><Q><Q><Y><S><N><T><Q><T><F><T><G><K><K><G><R><Y><F><C>
May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.<BOP>
Q8TAP9
Q96GR4
ZDH12_HUMAN
Zinc finger protein 400
Homo
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Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission.<BOP>
Q96GR4
P06331
HV434_HUMAN
Ig heavy chain V-II region ARH-77
Homo
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V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P06331
D6RA61
U17LM_HUMAN
Ubiquitin carboxyl-terminal hydrolase 17-like protein 22
Homo
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Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
D6RA61