accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q96SB4 | SRPK1_HUMAN | Serine/arginine-rich protein-specific kinase 1 | Homo | <M><E><R><K><V><L><A><L><Q><A><R><K><K><R><T><K><A><K><K><D><K><A><Q><R><K><S><E><T><Q><H><R><G><S><A><P><H><S><E><S><D><L><P><E><Q><E><E><E><I><L><G><S><D><D><D><E><Q><E><D><P><N><D><Y><C><K><G><G><Y><H><L><V><K><I><G><D><L><F><N><G><R><Y><H><V><I><R><K><L><G><W><G><H><F><S><T><V><W><L><S><W><D><I><Q><G><K><K><F><V><A... | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory... | Q96SB4 |
Q9UHV2 | SRTD1_HUMAN | Transcriptional regulator interacting with the PHD-bromodomain 1 | Homo | <M><L><S><K><G><L><K><R><K><R><E><E><E><E><E><K><E><P><L><A><V><D><S><W><W><L><D><P><G><H><T><A><V><A><Q><A><P><P><A><V><A><S><S><S><L><F><D><L><S><V><L><K><L><H><H><S><L><Q><Q><S><E><P><D><L><R><H><L><V><L><V><V><N><T><L><R><R><I><Q><A><S><M><A><P><A><A><A><L><P><P><V><P><S><P><P><A><A><P><S><V><A><D><N><L><L><A><S><S... | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.<BOP> | Q9UHV2 |
Q9HCP6 | HHATL_HUMAN | Hedgehog acyltransferase-like protein | Homo | <M><G><I><K><T><A><L><P><A><A><E><L><G><L><Y><S><L><V><L><S><G><A><L><A><Y><A><G><R><G><L><L><E><A><S><Q><D><G><A><H><R><K><A><F><R><E><S><V><R><P><G><W><E><Y><I><G><R><K><M><D><V><A><D><F><E><W><V><M><W><F><T><S><F><R><N><V><I><I><F><A><L><S><G><H><V><L><F><A><K><L><C><T><M><V><A><P><K><L><R><S><W><M><Y><A><V><Y><G><A... | Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.<BOP> | Q9HCP6 |
Q9H9H4 | VP37B_HUMAN | ESCRT-I complex subunit VPS37B | Homo | <M><A><G><A><G><S><E><A><R><F><A><G><L><S><L><V><Q><L><N><E><L><L><E><D><E><G><Q><L><T><E><M><V><Q><K><M><E><E><T><Q><N><V><Q><L><N><K><E><M><T><L><A><S><N><R><S><L><A><E><G><N><L><L><Y><Q><P><Q><L><D><T><L><K><A><R><L><T><Q><K><Y><Q><E><L><Q><V><L><F><E><A><Y><Q><I><K><K><T><K><L><D><R><Q><S><S><S><A><S><L><E><T><L><L... | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.<BOP> | Q9H9H4 |
Q01664 | TFAP4_HUMAN | Class C basic helix-loop-helix protein 41 | Homo | <M><E><Y><F><M><V><P><T><Q><K><V><P><S><L><Q><H><F><R><K><T><E><K><E><V><I><G><G><L><C><S><L><A><N><I><P><L><T><P><E><T><Q><R><D><Q><E><R><R><I><R><R><E><I><A><N><S><N><E><R><R><R><M><Q><S><I><N><A><G><F><Q><S><L><K><T><L><I><P><H><T><D><G><E><K><L><S><K><A><A><I><L><Q><Q><T><A><E><Y><I><F><S><L><E><Q><E><K><T><R><L><L... | Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.<BOP> | Q01664 |
Q9P287 | BCCIP_HUMAN | Protein TOK-1 | Homo | <M><A><S><R><S><K><R><R><A><V><E><S><G><V><P><Q><P><P><D><P><P><V><Q><R><D><E><E><E><E><K><E><V><E><N><E><D><E><D><D><D><D><S><D><K><E><K><D><E><E><D><E><V><I><D><E><E><V><N><I><E><F><E><A><Y><S><L><S><D><N><D><Y><D><G><I><K><K><L><L><Q><Q><L><F><L><K><A><P><V><N><T><A><E><L><T><D><L><L><I><Q><Q><N><H><I><G><S><V><I><K... | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole . Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientatio... | Q9P287 |
Q3YEC7 | RABL6_HUMAN | Rab-like protein 1 | Homo | <M><F><S><A><L><K><K><L><V><G><S><D><Q><A><P><G><R><D><K><N><I><P><A><G><L><Q><S><M><N><Q><A><L><Q><R><R><F><A><K><G><V><Q><Y><N><M><K><I><V><I><R><G><D><R><N><T><G><K><T><A><L><W><H><R><L><Q><G><R><P><F><V><E><E><Y><I><P><T><Q><E><I><Q><V><T><S><I><H><W><S><Y><K><T><T><D><D><I><V><K><V><E><V><W><D><V><V><D><K><G><K><C... | May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.<BOP> | Q3YEC7 |
P50539 | MXI1_HUMAN | Class C basic helix-loop-helix protein 11 | Homo | <M><E><R><V><K><M><I><N><V><Q><R><L><L><E><A><A><E><F><L><E><R><R><E><R><E><C><E><H><G><Y><A><S><S><F><P><S><M><P><S><P><R><L><Q><H><S><K><P><P><R><R><L><S><R><A><Q><K><H><S><S><G><S><S><N><T><S><T><A><N><R><S><T><H><N><E><L><E><K><N><R><R><A><H><L><R><L><C><L><E><R><L><K><V><L><I><P><L><G><P><D><C><T><R><H><T><T><L><G... | Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.<BOP> | P50539 |
P08651 | NFIC_HUMAN | TGGCA-binding protein | Homo | <M><Y><S><S><P><L><C><L><T><Q><D><E><F><H><P><F><I><E><A><L><L><P><H><V><R><A><F><A><Y><T><W><F><N><L><Q><A><R><K><R><K><Y><F><K><K><H><E><K><R><M><S><K><D><E><E><R><A><V><K><D><E><L><L><G><E><K><P><E><V><K><Q><K><W><A><S><R><L><L><A><K><L><R><K><D><I><R><P><E><C><R><E><D><F><V><L><S><I><T><G><K><K><A><P><G><C><V><L><S... | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.<BOP> | P08651 |
Q16630 | CPSF6_HUMAN | Protein HPBRII-4/7 | Homo | <M><A><D><G><V><D><H><I><D><I><Y><A><D><V><G><E><E><F><N><Q><E><A><E><Y><G><G><H><D><Q><I><D><L><Y><D><D><V><I><S><P><S><A><N><N><G><D><A><P><E><D><R><D><Y><M><D><T><L><P><P><T><V><G><D><D><V><G><K><G><A><A><P><N><V><V><Y><T><Y><T><G><K><R><I><A><L><Y><I><G><N><L><T><W><W><T><T><D><E><D><L><T><E><A><V><H><S><L><G><V><N... | (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).<BOP> | Q16630 |
Q96A61 | TRI52_HUMAN | Tripartite motif-containing protein 52 | Homo | <M><A><G><Y><A><T><T><P><S><P><M><Q><T><L><Q><E><E><A><V><C><A><I><C><L><D><Y><F><K><D><P><V><S><I><S><C><G><H><N><F><C><R><G><C><V><T><Q><L><W><S><K><E><D><E><E><D><Q><N><E><E><E><D><E><W><E><E><E><E><D><E><E><A><V><G><A><M><D><G><W><D><G><S><I><R><E><V><L><Y><R><G><N><A><D><E><E><L><F><Q><D><Q><D><D><D><E><L><W><L><G... | (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.<BOP> | Q96A61 |
Q07812 | BAX_HUMAN | Bcl-2-like protein 4 | Homo | <M><D><G><S><G><E><Q><P><R><G><G><G><P><T><S><S><E><Q><I><M><K><T><G><A><L><L><L><Q><G><F><I><Q><D><R><A><G><R><M><G><G><E><A><P><E><L><A><L><D><P><V><P><Q><D><A><S><T><K><K><L><S><E><C><L><K><R><I><G><D><E><L><D><S><N><M><E><L><Q><R><M><I><A><A><V><D><T><D><S><P><R><E><V><F><F><R><V><A><A><D><M><F><S><D><G><N><F><N><W... | Plays a role in the mitochondrial apoptotic process . Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) . Under stress conditions, undergoes... | Q07812 |
P0DMM9 | ST1A3_HUMAN | Thermolabile phenol sulfotransferase | Homo | <M><E><L><I><Q><D><T><S><R><P><P><L><E><Y><V><K><G><V><P><L><I><K><Y><F><A><E><A><L><G><P><L><Q><S><F><Q><A><R><P><D><D><L><L><I><N><T><Y><P><K><S><G><T><T><W><V><S><Q><I><L><D><M><I><Y><Q><G><G><D><L><E><K><C><N><R><A><P><I><Y><V><R><V><P><F><L><E><V><N><D><P><G><E><P><S><G><L><E><T><L><K><D><T><P><P><P><R><L><I><K><S... | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.<BOP> | P0DMM9 |
A6NEQ0 | RBY1E_HUMAN | RNA-binding motif protein, Y chromosome, family 1 member E | Homo | <M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G... | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.<BOP> | A6NEQ0 |
Q6IV72 | ZN425_HUMAN | Zinc finger protein 425 | Homo | <M><A><E><P><A><S><V><T><V><T><F><D><D><V><A><L><Y><F><S><E><Q><E><W><E><I><L><E><K><W><Q><K><Q><M><Y><K><Q><E><M><K><T><N><Y><E><T><L><D><S><L><G><Y><A><F><S><K><P><D><L><I><T><W><M><E><Q><G><R><M><L><L><I><S><E><Q><G><C><L><D><K><T><R><R><T><T><S><P><P><T><D><E><Q><L><N><M><K><N><T><G><K><L><L><C><F><D><D><E><G><T><P... | Acts as a transcriptional repressor.<BOP> | Q6IV72 |
Q9NTM9 | CUTC_HUMAN | Copper homeostasis protein cutC homolog | Homo | <M><K><R><Q><G><A><S><S><E><R><K><R><A><R><I><P><S><G><K><A><G><A><A><N><G><F><L><M><E><V><C><V><D><S><V><E><S><A><V><N><A><E><R><G><G><A><D><R><I><E><L><C><S><G><L><S><E><G><G><T><T><P><S><M><G><V><L><Q><V><V><K><Q><S><V><Q><I><P><V><F><V><M><I><R><P><R><G><G><D><F><L><Y><S><D><R><E><I><E><V><M><K><A><D><I><R><L><A><K... | May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.<BOP> | Q9NTM9 |
A6NMN3 | F170B_HUMAN | Acrosome-related protein | Homo | <M><K><C><Y><F><T><D><H><R><G><E><Q><S><P><T><D><G><T><T><L><S><L><T><S><P><E><S><T><E><E><S><V><E><V><F><W><P><G><T><I><Q><R><E><G><S><S><P><R><P><G><P><A><I><P><R><E><E><G><L><Y><F><A><A><R><D><R><G><M><R><D><W><S><S><S><P><S><S><E><S><S><E><Y><Q><S><Y><S><Q><Y><Q><S><C><C><S><C><M><C><D><E><D><N><A><A><P><Q><S><V><C... | Plays a role in fertilization through the acrosome reaction.<BOP> | A6NMN3 |
O75818 | RPP40_HUMAN | RNase P subunit 1 | Homo | <M><A><T><L><R><R><L><R><E><A><P><R><H><L><L><V><C><E><K><S><N><F><G><N><H><K><S><R><H><R><H><L><V><Q><T><H><Y><Y><N><Y><R><V><S><F><L><I><P><E><C><G><I><L><S><E><E><L><K><N><L><V><M><N><T><G><P><Y><Y><F><V><K><N><L><P><L><H><E><L><I><T><P><E><F><I><S><T><F><I><K><K><G><S><C><Y><A><L><T><Y><N><T><H><I><D><E><D><N><T><V... | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends . Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences .<BOP> | O75818 |
Q9UK33 | ZN580_HUMAN | LDL-induced EC protein | Homo | <M><L><L><L><P><P><R><P><P><H><P><R><S><S><S><P><E><A><M><D><P><P><P><P><K><A><P><P><F><P><K><A><E><G><P><S><S><T><P><S><S><A><A><G><P><R><P><P><R><L><G><R><H><L><L><I><D><A><N><G><V><P><Y><T><Y><T><V><Q><L><E><E><E><P><R><G><P><P><Q><R><E><A><P><P><G><E><P><G><P><R><K><G><Y><S><C><P><E><C><A><R><V><F><A><S><P><L><R><L... | Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.<BOP> | Q9UK33 |
Q96R54 | O14A2_HUMAN | Olfactory receptor OR1-31 | Homo | <M><A><N><V><T><L><V><T><G><F><L><L><M><G><F><S><N><I><Q><K><L><R><I><L><Y><G><V><L><F><L><L><I><Y><L><A><A><L><M><S><N><L><L><I><I><T><L><I><T><L><D><V><K><L><Q><T><P><M><Y><F><F><L><K><N><L><S><F><L><D><V><F><L><V><S><V><P><I><P><K><F><I><V><N><N><L><T><H><N><N><S><I><S><I><L><G><C><A><F><Q><L><L><L><M><T><S><F><S><A... | Odorant receptor.<BOP> | Q96R54 |
Q8N428 | GLT16_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1 | Homo | <M><R><K><I><R><A><N><A><I><A><I><L><T><V><A><W><I><L><G><T><F><Y><Y><L><W><Q><D><N><R><A><H><A><A><S><S><G><G><R><G><A><Q><R><A><G><R><R><S><E><Q><L><R><E><D><R><T><I><P><L><I><V><T><G><T><P><S><K><G><F><D><E><K><A><Y><L><S><A><K><Q><L><K><A><G><E><D><P><Y><R><Q><H><A><F><N><Q><L><E><S><D><K><L><S><P><D><R><P><I><R><D... | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.<BOP> | Q8N428 |
Q9UBE0 | SAE1_HUMAN | SUMO-activating enzyme subunit 1, N-terminally processed | Homo | <M><V><E><K><E><E><A><G><G><G><I><S><E><E><E><A><A><Q><Y><D><R><Q><I><R><L><W><G><L><E><A><Q><K><R><L><R><A><S><R><V><L><L><V><G><L><K><G><L><G><A><E><I><A><K><N><L><I><L><A><G><V><K><G><L><T><M><L><D><H><E><Q><V><T><P><E><D><P><G><A><Q><F><L><I><R><T><G><S><V><G><R><N><R><A><E><A><S><L><E><R><A><Q><N><L><N><P><M><V><D... | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<BOP> | Q9UBE0 |
O94952 | FBX21_HUMAN | F-box only protein 21 | Homo | <M><A><A><A><A><V><D><S><A><M><E><V><V><P><A><L><A><E><E><A><A><P><E><V><A><G><L><S><C><L><V><N><L><P><G><E><V><L><E><Y><I><L><C><C><G><S><L><T><A><A><D><I><G><R><V><S><S><T><C><R><R><L><R><E><L><C><Q><S><S><G><K><V><W><K><E><Q><F><R><V><R><W><P><S><L><M><K><H><Y><S><P><T><D><Y><V><N><W><L><E><E><Y><K><V><R><Q><K><A><G... | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP> | O94952 |
P14091 | CATE_HUMAN | Cathepsin E form II | Homo | <M><K><T><L><L><L><L><L><L><V><L><L><E><L><G><E><A><Q><G><S><L><H><R><V><P><L><R><R><H><P><S><L><K><K><K><L><R><A><R><S><Q><L><S><E><F><W><K><S><H><N><L><D><M><I><Q><F><T><E><S><C><S><M><D><Q><S><A><K><E><P><L><I><N><Y><L><D><M><E><Y><F><G><T><I><S><I><G><S><P><P><Q><N><F><T><V><I><F><D><T><G><S><S><N><L><W><V><P><S><V... | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.<BOP> | P14091 |
P53990 | IST1_HUMAN | Putative MAPK-activating protein PM28 | Homo | <M><L><G><S><G><F><K><A><E><R><L><R><V><N><L><R><L><V><I><N><R><L><K><L><L><E><K><K><K><T><E><L><A><Q><K><A><R><K><E><I><A><D><Y><L><A><A><G><K><D><E><R><A><R><I><R><V><E><H><I><I><R><E><D><Y><L><V><E><A><M><E><I><L><E><L><Y><C><D><L><L><L><A><R><F><G><L><I><Q><S><M><K><E><L><D><S><G><L><A><E><S><V><S><T><L><I><W><A><A... | ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation . Is required for efficient abscission during cytokinesis . Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells . During late anaphase, involved in nuclear envelope reassembly and mitotic spindle ... | P53990 |
P0C645 | OR4E1_HUMAN | Olfactory receptor OR14-43 | Homo | <M><E><E><A><I><L><L><N><Q><T><S><L><V><T><Y><F><R><L><R><G><L><S><V><N><H><K><A><R><I><A><M><F><S><M><F><L><I><F><Y><V><L><T><L><I><G><N><V><L><I><V><I><T><I><I><Y><D><H><R><L><H><T><P><M><Y><F><F><L><S><N><L><S><F><I><D><V><C><H><S><T><V><T><V><P><K><M><L><R><D><V><W><S><E><E><K><L><I><S><F><D><A><C><V><T><Q><M><F><F... | Odorant receptor.<BOP> | P0C645 |
O75712 | CXB3_HUMAN | Connexin-31 | Homo | <M><D><W><K><T><L><Q><A><L><L><S><G><V><N><K><Y><S><T><A><F><G><R><I><W><L><S><V><V><F><V><F><R><V><L><V><Y><V><V><A><A><E><R><V><W><G><D><E><Q><K><D><F><D><C><N><T><K><Q><P><G><C><T><N><V><C><Y><D><N><Y><F><P><I><S><N><I><R><L><W><A><L><Q><L><I><F><V><T><C><P><S><L><L><V><I><L><H><V><A><Y><R><E><E><R><E><R><R><H><R><Q... | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP> | O75712 |
Q9Y471 | CMAH_HUMAN | Cytidine monophosphate-N-acetylneuraminic acid hydroxylase pseudogene | Homo | <M><D><E><N><N><G><L><L><L><L><E><L><N><P><P><N><P><W><D><L><Q><P><R><S><P><E><E><L><A><F><G><E><V><Q><I><T><Y><L><T><H><A><C><M><D><L><K><L><G><D><K><R><M><V><F><D><P><W><L><I><G><P><A><F><A><R><G><W><W><L><L><H><E><P><P><S><D><W><L><E><R><L><C><Q><A><D><L><I><Y><I><S><H><L><H><S><D><H><L><S><Y><P><T><L><K><K><L><A><G... | Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-gl... | Q9Y471 |
Q8NET1 | D108B_HUMAN | Defensin, beta 108B | Homo | <M><R><I><A><V><L><L><F><A><I><F><F><F><M><S><Q><V><L><P><A><R><G><K><F><K><E><I><C><E><R><P><N><G><S><C><R><D><F><C><L><E><T><E><I><H><V><G><R><C><L><N><S><Q><P><C><C><L><P><L><G><H><Q><P><R><I><E><S><T><T><P><K><K><D> | Has antibacterial activity.<BOP> | Q8NET1 |
Q9H1K1 | ISCU_HUMAN | NifU-like protein | Homo | <M><A><A><A><G><A><F><R><L><R><R><A><A><S><A><L><L><L><R><S><P><R><L><P><A><R><E><L><S><A><P><A><R><L><Y><H><K><K><V><V><D><H><Y><E><N><P><R><N><V><G><S><L><D><K><T><S><K><N><V><G><T><G><L><V><G><A><P><A><C><G><D><V><M><K><L><Q><I><Q><V><D><E><K><G><K><I><V><D><A><R><F><K><T><F><G><C><G><S><A><I><A><S><S><S><L><A><T><E... | Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm.<BOP> | Q9H1K1 |
Q9NQB0 | TF7L2_HUMAN | T-cell-specific transcription factor 4 | Homo | <M><P><Q><L><N><G><G><G><G><D><D><L><G><A><N><D><E><L><I><S><F><K><D><E><G><E><Q><E><E><K><S><S><E><N><S><S><A><E><R><D><L><A><D><V><K><S><S><L><V><N><E><S><E><T><N><Q><N><S><S><S><D><S><E><A><E><R><R><P><P><P><R><S><E><S><F><R><D><K><S><R><E><S><L><E><E><A><A><K><R><Q><D><G><G><L><F><K><G><P><P><Y><P><G><Y><P><F><I><M... | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CT... | Q9NQB0 |
Q96BF6 | NACC2_HUMAN | Repressor with BTB domain and BEN domain | Homo | <M><S><Q><M><L><H><I><E><I><P><N><F><G><N><T><V><L><G><C><L><N><E><Q><R><L><L><G><L><Y><C><D><V><S><I><V><V><K><G><Q><A><F><K><A><H><R><A><V><L><A><A><S><S><L><Y><F><R><D><L><F><S><G><N><S><K><S><A><F><E><L><P><G><S><V><P><P><A><C><F><Q><Q><I><L><S><F><C><Y><T><G><R><L><T><M><T><A><S><E><Q><L><V><V><M><Y><T><A><G><F><L... | Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.<BOP> | Q96BF6 |
Q9NXK8 | FXL12_HUMAN | F-box protein FBL12 | Homo | <M><A><T><L><V><E><L><P><D><S><V><L><L><E><I><F><S><Y><L><P><V><R><D><R><I><R><I><S><R><V><C><H><R><W><K><R><L><V><D><D><R><W><L><W><R><H><V><D><L><T><L><Y><T><M><R><P><K><V><M><W><H><L><L><R><R><Y><M><A><S><R><L><H><S><L><R><M><G><G><Y><L><F><S><G><S><Q><A><P><Q><L><S><P><A><L><L><R><A><L><G><Q><K><C><P><N><L><K><R><L... | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.<BOP> | Q9NXK8 |
Q8TDN2 | KCNV2_HUMAN | Voltage-gated potassium channel subunit Kv8.2 | Homo | <M><L><K><Q><S><E><R><R><R><S><W><S><Y><R><P><W><N><T><T><E><N><E><G><S><Q><H><R><R><S><I><C><S><L><G><A><R><S><G><S><Q><A><S><I><H><G><W><T><E><G><N><Y><N><Y><Y><I><E><E><D><E><D><G><E><E><E><D><Q><W><K><D><D><L><A><E><E><D><Q><Q><A><G><E><V><T><T><A><K><P><E><G><P><S><D><P><P><A><L><L><S><T><L><N><V><N><V><G><G><H><S... | Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.<BOP> | Q8TDN2 |
Q96RP9 | EFGM_HUMAN | Elongation factor G1 | Homo | <M><R><L><L><G><A><A><A><V><A><A><L><G><R><G><R><A><P><A><S><L><G><W><Q><R><K><Q><V><N><W><K><A><C><R><W><S><S><S><G><V><I><P><N><E><K><I><R><N><I><G><I><S><A><H><I><D><S><G><K><T><T><L><T><E><R><V><L><Y><Y><T><G><R><I><A><K><M><H><E><V><K><G><K><D><G><V><G><A><V><M><D><S><M><E><L><E><R><Q><R><G><I><T><I><Q><S><A><A><T... | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the... | Q96RP9 |
Q14592 | ZN460_HUMAN | Zinc finger protein HZF8 | Homo | <M><A><A><A><W><M><A><P><A><Q><E><S><V><T><F><E><D><V><A><V><T><F><T><Q><E><E><W><G><Q><L><D><V><T><Q><R><A><L><Y><V><E><V><M><L><E><T><C><G><L><L><V><A><L><G><D><S><T><K><P><E><T><V><E><P><I><P><S><H><L><A><L><P><E><E><V><S><L><Q><E><Q><L><A><Q><G><V><P><R><Y><S><Y><L><G><Q><A><M><D><Q><D><G><P><S><E><M><Q><E><Y><F><L... | May be involved in transcriptional regulation.<BOP> | Q14592 |
Q9Y2T3 | GUAD_HUMAN | p51-nedasin | Homo | <M><C><A><A><Q><M><P><P><L><A><H><I><F><R><G><T><F><V><H><S><T><W><T><C><P><M><E><V><L><R><D><H><L><L><G><V><S><D><S><G><K><I><V><F><L><E><E><A><S><Q><Q><E><K><L><A><K><E><W><C><F><K><P><C><E><I><R><E><L><S><H><H><E><F><F><M><P><G><L><V><D><T><H><I><H><A><S><Q><Y><S><F><A><G><S><S><I><D><L><P><L><L><E><W><L><T><K><Y><T... | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.<BOP> | Q9Y2T3 |
Q96LX8 | ZN597_HUMAN | Zinc finger protein 597 | Homo | <M><A><S><M><P><P><T><P><E><A><Q><G><P><I><L><F><E><D><L><A><V><Y><F><S><Q><E><E><C><V><T><L><H><P><A><Q><R><S><L><S><K><D><G><T><K><E><S><L><E><D><A><A><L><M><G><E><E><G><K><P><E><I><N><Q><Q><L><S><L><E><S><M><E><L><D><E><L><A><L><E><K><Y><P><I><A><A><P><L><V><P><Y><P><E><K><S><S><E><D><G><V><G><N><P><E><A><K><I><L><S... | May be involved in transcriptional regulation.<BOP> | Q96LX8 |
P01589 | IL2RA_HUMAN | p55 | Homo | <M><D><S><Y><L><L><M><W><G><L><L><T><F><I><M><V><P><G><C><Q><A><E><L><C><D><D><D><P><P><E><I><P><H><A><T><F><K><A><M><A><Y><K><E><G><T><M><L><N><C><E><C><K><R><G><F><R><R><I><K><S><G><S><L><Y><M><L><C><T><G><N><S><S><H><S><S><W><D><N><Q><C><Q><C><T><S><S><A><T><R><N><T><T><K><Q><V><T><P><Q><P><E><E><Q><K><E><R><K><T><T... | Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.<BOP> | P01589 |
Q9UBM7 | DHCR7_HUMAN | Sterol reductase SR-2 | Homo | <M><A><A><K><S><Q><P><N><I><P><K><A><K><S><L><D><G><V><T><N><D><R><T><A><S><Q><G><Q><W><G><R><A><W><E><V><D><W><F><S><L><A><S><V><I><F><L><L><L><F><A><P><F><I><V><Y><Y><F><I><M><A><C><D><Q><Y><S><C><A><L><T><G><P><V><V><D><I><V><T><G><H><A><R><L><S><D><I><W><A><K><T><P><P><I><T><R><K><A><A><Q><L><Y><T><L><W><V><T><F><Q... | 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway.<BOP> | Q9UBM7 |
Q8WUJ1 | NEUFC_HUMAN | Cytochrome b5 domain-containing protein 2 | Homo | <M><L><R><C><G><G><R><G><L><L><L><G><L><A><V><A><A><A><A><V><M><A><A><R><L><M><G><W><W><G><P><R><A><G><F><R><L><F><I><P><E><E><L><S><R><Y><R><G><G><P><G><D><P><G><L><Y><L><A><L><L><G><R><V><Y><D><V><S><S><G><R><R><H><Y><E><P><G><S><H><Y><S><G><F><A><G><R><D><A><S><R><A><F><V><T><G><D><C><S><E><A><G><L><V><D><D><V><S><D... | Heme-binding protein which promotes neuronal but not astrocyte differentiation.<BOP> | Q8WUJ1 |
Q93038 | TNR25_HUMAN | Protein WSL-1 | Homo | <M><E><Q><R><P><R><G><C><A><A><V><A><A><A><L><L><L><V><L><L><G><A><R><A><Q><G><G><T><R><S><P><R><C><D><C><A><G><D><F><H><K><K><I><G><L><F><C><C><R><G><C><P><A><G><H><Y><L><K><A><P><C><T><E><P><C><G><N><S><T><C><L><V><C><P><Q><D><T><F><L><A><W><E><N><H><H><N><S><E><C><A><R><C><Q><A><C><D><E><Q><A><S><Q><V><A><L><E><N><C... | Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.<BOP> | Q93038 |
Q96FV9 | THOC1_HUMAN | hTREX84 | Homo | <M><S><P><T><P><P><L><F><S><L><P><E><A><R><T><R><F><T><K><S><T><R><E><A><L><N><N><K><N><I><K><P><L><L><S><T><F><S><Q><V><P><G><S><E><N><E><K><K><C><T><L><D><Q><A><F><R><G><I><L><E><E><E><I><I><N><H><S><S><C><E><N><V><L><A><I><I><S><L><A><I><G><G><V><T><E><G><I><C><T><A><S><T><P><F><V><L><L><G><D><V><L><D><C><L><P><L><D... | Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint pri... | Q96FV9 |
Q6P1L8 | RM14_HUMAN | Mitochondrial large ribosomal subunit protein uL14m | Homo | <M><A><F><F><T><G><L><W><G><P><F><T><C><V><S><R><V><L><S><H><H><C><F><S><T><T><G><S><L><S><A><I><Q><K><M><T><R><V><R><V><V><D><N><S><A><L><G><N><S><P><Y><H><R><A><P><R><C><I><H><V><Y><K><K><N><G><V><G><K><V><G><D><Q><I><L><L><A><I><K><G><Q><K><K><K><A><L><I><V><G><H><C><M><P><G><P><R><M><T><P><R><F><D><S><N><N><V><V><L... | Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).<BOP> | Q6P1L8 |
Q9H3U5 | MFSD1_HUMAN | Smooth muscle cell-associated protein 4 | Homo | <M><E><E><E><D><E><E><A><R><A><L><L><A><G><G><P><D><E><A><D><R><G><A><P><A><A><P><G><A><L><P><A><L><C><D><P><S><R><L><A><H><R><L><L><V><L><L><L><M><C><F><L><G><F><G><S><Y><F><C><Y><D><N><P><A><A><L><Q><T><Q><V><K><R><D><M><Q><V><N><T><T><K><F><M><L><L><Y><A><W><Y><S><W><P><N><V><V><L><C><F><F><G><G><F><L><I><D><R><V><F... | Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.<BOP> | Q9H3U5 |
Q14568 | HS902_HUMAN | Heat shock protein HSP 90-alpha A2 pseudogene | Homo | <M><P><E><E><T><Q><T><Q><D><Q><P><M><E><E><E><E><V><E><T><F><A><F><Q><A><E><I><A><Q><L><M><S><L><I><I><N><T><F><Y><S><N><K><E><I><F><L><R><E><L><I><S><N><S><S><D><A><L><D><K><I><W><Y><E><S><L><T><D><P><S><K><L><D><S><G><K><E><L><H><I><N><L><I><P><N><K><Q><D><Q><T><L><T><I><V><D><T><G><I><G><M><T><K><A><D><L><I><N><N><L... | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.<BOP> | Q14568 |
A2RU49 | HYKK_HUMAN | Aminoglycoside phosphotransferase domain-containing protein 1 | Homo | <M><S><S><G><N><Y><Q><Q><S><E><A><L><S><K><P><T><F><S><E><E><Q><A><S><A><L><V><E><S><V><F><G><L><K><V><S><K><V><R><P><L><P><S><Y><D><D><Q><N><F><H><V><Y><V><S><K><T><K><D><G><P><T><E><Y><V><L><K><I><S><N><T><K><A><S><K><N><P><D><L><I><E><V><Q><N><H><I><I><M><F><L><K><A><A><G><F><P><T><A><S><V><C><H><T><K><G><D><N><T><A... | Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.<BOP> | A2RU49 |
P62324 | BTG1_HUMAN | B-cell translocation gene 1 protein | Homo | <M><H><P><F><Y><T><R><A><A><T><M><I><G><E><I><A><A><A><V><S><F><I><S><K><F><L><R><T><K><G><L><T><S><E><R><Q><L><Q><T><F><S><Q><S><L><Q><E><L><L><A><E><H><Y><K><H><H><W><F><P><E><K><P><C><K><G><S><G><Y><R><C><I><R><I><N><H><K><M><D><P><L><I><G><Q><A><A><Q><R><I><G><L><S><S><Q><E><L><F><R><L><L><P><S><E><L><T><L><W><V><D... | Anti-proliferative protein.<BOP> | P62324 |
P51857 | AK1D1_HUMAN | Delta(4)-3-oxosteroid 5-beta-reductase | Homo | <M><D><L><S><A><A><S><H><R><I><P><L><S><D><G><N><S><I><P><I><I><G><L><G><T><Y><S><E><P><K><S><T><P><K><G><A><C><A><T><S><V><K><V><A><I><D><T><G><Y><R><H><I><D><G><A><Y><I><Y><Q><N><E><H><E><V><G><E><A><I><R><E><K><I><A><E><G><K><V><R><R><E><D><I><F><Y><C><G><K><L><W><A><T><N><H><V><P><E><M><V><R><P><T><L><E><R><T><L><R... | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of ... | P51857 |
Q8IZN7 | D107A_HUMAN | Defensin, beta 107 | Homo | <M><P><G><A><M><K><I><F><V><F><I><L><A><A><L><I><L><L><A><Q><I><F><Q><A><R><T><A><I><H><R><A><L><I><S><K><R><M><E><G><H><C><E><A><E><C><L><T><F><E><V><K><I><G><G><C><R><A><E><L><A><P><F><C><C><K><N><R><K><K><H> | Has antibacterial activity.<BOP> | Q8IZN7 |
Q8N2Z9 | CENPS_HUMAN | Fanconi anemia-associated polypeptide of 16 kDa | Homo | <M><E><E><E><A><E><T><E><E><Q><Q><R><F><S><Y><Q><Q><R><L><K><A><A><V><H><Y><T><V><G><C><L><C><E><E><V><A><L><D><K><E><M><Q><F><S><K><Q><T><I><A><A><I><S><E><L><T><F><R><Q><C><E><N><F><A><K><D><L><E><M><F><A><R><H><A><K><R><T><T><I><N><T><E><D><V><K><L><L><A><R><R><S><N><S><L><L><K><Y><I><T><D><K><S><E><E><I><A><Q><I><N... | DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage . In complex with CENPX (MHF he... | Q8N2Z9 |
A0A075B6T8 | TVA91_HUMAN | T cell receptor alpha variable 9-1 | Homo | <M><N><S><S><P><G><P><A><I><A><L><F><L><M><F><G><G><I><N><G><D><S><V><V><Q><T><E><G><Q><V><L><P><S><E><G><D><S><L><I><V><N><C><S><Y><E><T><T><Q><Y><P><S><L><F><W><Y><V><Q><Y><P><G><E><G><P><Q><L><H><L><K><A><M><K><A><N><D><K><G><R><N><K><G><F><E><A><M><Y><R><K><E><T><T><S><F><H><L><E><K><D><S><V><Q><E><S><D><S><A><V><Y... | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (... | A0A075B6T8 |
Q08257 | QOR_HUMAN | Zeta-crystallin | Homo | <M><A><T><G><Q><K><L><M><R><A><V><R><V><F><E><F><G><G><P><E><V><L><K><L><R><S><D><I><A><V><P><I><P><K><D><H><Q><V><L><I><K><V><H><A><C><G><V><N><P><V><E><T><Y><I><R><S><G><T><Y><S><R><K><P><L><L><P><Y><T><P><G><S><D><V><A><G><V><I><E><A><V><G><D><N><A><S><A><F><K><K><G><D><R><V><F><T><S><S><T><I><S><G><G><Y><A><E><Y><A... | Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of tar... | Q08257 |
Q8NGH7 | O52L1_HUMAN | Olfactory receptor OR11-50 | Homo | <M><T><L><V><S><F><F><S><F><L><S><K><P><L><I><M><L><L><S><N><S><S><W><R><L><S><Q><P><S><F><L><L><V><G><I><P><G><L><E><E><S><Q><H><W><I><A><L><P><L><G><I><L><Y><L><L><A><L><V><G><N><V><T><I><L><F><I><I><W><M><D><P><S><L><H><Q><S><M><Y><L><F><L><S><M><L><A><A><I><D><L><V><L><A><S><S><T><A><P><K><A><L><A><V><L><L><V><H><A... | Odorant receptor.<BOP> | Q8NGH7 |
Q9P0V9 | SEP10_HUMAN | Septin-10 | Homo | <M><A><S><S><E><V><A><R><H><L><L><F><Q><S><H><M><A><T><K><T><T><C><M><S><S><Q><G><S><D><D><E><Q><I><K><R><E><N><I><R><S><L><T><M><S><G><H><V><G><F><E><S><L><P><D><Q><L><V><N><R><S><I><Q><Q><G><F><C><F><N><I><L><C><V><G><E><T><G><I><G><K><S><T><L><I><D><T><L><F><N><T><N><F><E><D><Y><E><S><S><H><F><C><P><N><V><K><L><K><A... | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential).<BOP> | Q9P0V9 |
P17023 | ZNF19_HUMAN | Zinc finger protein KOX12 | Homo | <M><A><A><M><P><L><K><A><Q><Y><Q><E><M><V><T><F><E><D><V><A><V><H><F><T><K><T><E><W><T><G><L><S><P><A><Q><R><A><L><Y><R><S><V><M><L><E><N><F><G><N><L><T><A><L><G><Y><P><V><P><K><P><A><L><I><S><L><L><E><R><G><D><M><A><W><G><L><E><A><Q><D><D><P><P><A><E><R><T><K><N><V><C><K><D><V><E><T><N><I><D><S><E><S><T><L><I><Q><G><I... | May be involved in transcriptional regulation.<BOP> | P17023 |
Q99733 | NP1L4_HUMAN | Nucleosome assembly protein 2 | Homo | <M><A><D><H><S><F><S><D><G><V><P><S><D><S><V><E><A><A><K><N><A><S><N><T><E><K><L><T><D><Q><V><M><Q><N><P><R><V><L><A><A><L><Q><E><R><L><D><N><V><P><H><T><P><S><S><Y><I><E><T><L><P><K><A><V><K><R><R><I><N><A><L><K><Q><L><Q><V><R><C><A><H><I><E><A><K><F><Y><E><E><V><H><D><L><E><R><K><Y><A><A><L><Y><Q><P><L><F><D><K><R><R... | Acts as histone chaperone in nucleosome assembly.<BOP> | Q99733 |
Q8NH19 | O10AG_HUMAN | Olfactory receptor OR11-160 | Homo | <M><E><F><V><L><L><G><F><S><D><I><P><N><L><H><W><M><L><F><S><I><F><L><L><M><Y><L><M><I><L><M><C><N><G><I><I><I><L><L><I><K><I><H><P><A><L><Q><T><P><M><Y><F><F><L><S><N><F><S><L><L><E><I><C><Y><V><T><I><I><I><P><R><M><L><M><D><I><W><T><Q><K><G><N><I><S><L><F><A><C><A><T><Q><M><C><F><F><L><M><L><G><G><T><E><C><L><L><L><T... | Odorant receptor.<BOP> | Q8NH19 |
Q9NR22 | ANM8_HUMAN | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | Homo | <M><G><M><K><H><S><S><R><C><L><L><L><R><R><K><M><A><E><N><A><A><E><S><T><E><V><N><S><P><P><S><Q><P><P><Q><P><V><V><P><A><K><P><V><Q><C><V><H><H><V><S><T><Q><P><S><C><P><G><R><G><K><M><S><K><L><L><N><P><E><E><M><T><S><R><D><Y><Y><F><D><S><Y><A><H><F><G><I><H><E><E><M><L><K><D><E><V><R><T><L><T><Y><R><N><S><M><Y><H><N><K... | S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer . Able to mono- and dimethylate EWS pro... | Q9NR22 |
Q86UE6 | LRRT1_HUMAN | Leucine-rich repeat transmembrane neuronal protein 1 | Homo | <M><D><F><L><L><L><G><L><C><L><Y><W><L><L><R><R><P><S><G><V><V><L><C><L><L><G><A><C><F><Q><M><L><P><A><A><P><S><G><C><P><Q><L><C><R><C><E><G><R><L><L><Y><C><E><A><L><N><L><T><E><A><P><H><N><L><S><G><L><L><G><L><S><L><R><Y><N><S><L><S><E><L><R><A><G><Q><F><T><G><L><M><Q><L><T><W><L><Y><L><D><H><N><H><I><C><S><V><Q><G><D... | Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.<BOP> | Q86UE6 |
P15291 | B4GT1_HUMAN | Processed beta-1,4-galactosyltransferase 1 | Homo | <M><R><L><R><E><P><L><L><S><G><S><A><A><M><P><G><A><S><L><Q><R><A><C><R><L><L><V><A><V><C><A><L><H><L><G><V><T><L><V><Y><Y><L><A><G><R><D><L><S><R><L><P><Q><L><V><G><V><S><T><P><L><Q><G><G><S><N><S><A><A><A><I><G><Q><S><S><G><E><L><R><T><G><G><A><R><P><P><P><P><L><G><A><S><S><Q><P><R><P><G><G><D><S><S><P><V><V><D><S><G... | The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.<BOP> | P15291 |
P82251 | BAT1_HUMAN | Solute carrier family 7 member 9 | Homo | <M><G><D><T><G><L><R><K><R><R><E><D><E><K><S><I><Q><S><Q><E><P><K><T><T><S><L><Q><K><E><L><G><L><I><S><G><I><S><I><I><V><G><T><I><I><G><S><G><I><F><V><S><P><K><S><V><L><S><N><T><E><A><V><G><P><C><L><I><I><W><A><A><C><G><V><L><A><T><L><G><A><L><C><F><A><E><L><G><T><M><I><T><K><S><G><G><E><Y><P><Y><L><M><E><A><Y><G><P><I... | Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule.<BOP> | P82251 |
Q9NVW2 | RNF12_HUMAN | Renal carcinoma antigen NY-REN-43 | Homo | <M><E><N><S><D><S><N><D><K><G><S><G><D><Q><S><A><A><Q><R><R><S><Q><M><D><R><L><D><R><E><E><A><F><Y><Q><F><V><N><N><L><S><E><E><D><Y><R><L><M><R><D><N><N><L><L><G><T><P><G><E><S><T><E><E><E><L><L><R><R><L><Q><Q><I><K><E><G><P><P><P><Q><N><S><D><E><N><R><G><G><D><S><S><D><D><V><S><N><G><D><S><I><I><D><W><L><N><S><V><R><Q... | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofact... | Q9NVW2 |
Q9UM13 | APC10_HUMAN | Cyclosome subunit 10 | Homo | <M><T><T><P><N><K><T><P><P><G><A><D><P><K><Q><L><E><R><T><G><T><V><R><E><I><G><S><Q><A><V><W><S><L><S><S><C><K><P><G><F><G><V><D><Q><L><R><D><D><N><L><E><T><Y><W><Q><S><D><G><S><Q><P><H><L><V><N><I><Q><F><R><R><K><T><T><V><K><T><L><C><I><Y><A><D><Y><K><S><D><E><S><Y><T><P><S><K><I><S><V><R><V><G><N><N><F><H><N><L><Q><E... | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'L... | Q9UM13 |
O43325 | LYRM1_HUMAN | LYR motif-containing protein 1 | Homo | <M><T><T><A><T><R><Q><E><V><L><G><L><Y><R><S><I><F><R><L><A><R><K><W><Q><A><T><S><G><Q><M><E><D><T><I><K><E><K><Q><Y><I><L><N><E><A><R><T><L><F><R><K><N><K><N><L><T><D><T><D><L><I><K><Q><C><I><D><E><C><T><A><R><I><E><I><G><L><H><Y><K><I><P><Y><P><R><P><I><H><L><P><P><M><G><L><T><P><L><R><G><R><G><L><R><S><Q><E><K><L><R... | May promote cell proliferation and inhibition of apoptosis of preadipocytes.<BOP> | O43325 |
Q9BT17 | MTG1_HUMAN | Mitochondrial GTPase 1 | Homo | <M><R><L><T><P><R><A><L><C><S><A><A><Q><A><A><W><R><E><N><F><P><L><C><G><R><D><V><A><R><W><F><P><G><H><M><A><K><G><L><K><K><M><Q><S><S><L><K><L><V><D><C><I><I><E><V><H><D><A><R><I><P><L><S><G><R><N><P><L><F><Q><E><T><L><G><L><K><P><H><L><L><V><L><N><K><M><D><L><A><D><L><T><E><Q><Q><K><I><M><Q><H><L><E><G><E><G><L><K><N... | Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.<BOP> | Q9BT17 |
Q96FE7 | P3IP1_HUMAN | Kringle domain-containing protein HGFL | Homo | <M><L><L><A><W><V><Q><A><F><L><V><S><N><M><L><L><A><E><A><Y><G><S><G><G><C><F><W><D><N><G><H><L><Y><R><E><D><Q><T><S><P><A><P><G><L><R><C><L><N><W><L><D><A><Q><S><G><L><A><S><A><P><V><S><G><A><G><N><H><S><Y><C><R><N><P><D><E><D><P><R><G><P><W><C><Y><V><S><G><E><A><G><V><P><E><K><R><P><C><E><D><L><R><C><P><E><T><T><S><Q... | Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.<BOP> | Q96FE7 |
P41145 | OPRK_HUMAN | Kappa-type opioid receptor | Homo | <M><D><S><P><I><Q><I><F><R><G><E><P><G><P><T><C><A><P><S><A><C><L><P><P><N><S><S><A><W><F><P><G><W><A><E><P><D><S><N><G><S><A><G><S><E><D><A><Q><L><E><P><A><H><I><S><P><A><I><P><V><I><I><T><A><V><Y><S><V><V><F><V><V><G><L><V><G><N><S><L><V><M><F><V><I><I><R><Y><T><K><M><K><T><A><T><N><I><Y><I><F><N><L><A><L><A><D><A><L... | G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers si... | P41145 |
P22528 | SPR1B_HUMAN | Small proline-rich protein IB | Homo | <M><S><S><Q><Q><Q><K><Q><P><C><T><P><P><P><Q><L><Q><Q><Q><Q><V><K><Q><P><C><Q><P><P><P><Q><E><P><C><I><P><K><T><K><E><P><C><H><P><K><V><P><E><P><C><H><P><K><V><P><E><P><C><Q><P><K><V><P><E><P><C><H><P><K><V><P><E><P><C><P><S><I><V><T><P><A><P><A><Q><Q><K><T><K><Q><K> | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and ... | P22528 |
Q6XLA1 | CSC2A_HUMAN | Cancer susceptibility candidate gene 2 protein, isoform 3 | Homo | <M><T><Q><E><K><M><Y><P><H><L><F><S><E><R><C><A><N><Q><H><Q><H><R><T><A><E><E><K><K><Y><V><S><E><K><Q><L><I><H><W><R><C><E><E><P><S><A><H><H><N><S><I><D><I><K><R><M><K><H><F><G><S><A><L><R><L><R><Q><T><F><H><L><D><T><A><D><H><P><C><V><I><T><M><N><P><A><L><P><W><K><L><E><G><S><N><S><T><S><T><L><P><L><P><A> | May act as a potential tumor suppressor.<BOP> | Q6XLA1 |
Q92783 | STAM1_HUMAN | Signal transducing adapter molecule 1 | Homo | <M><P><L><F><A><T><N><P><F><D><Q><D><V><E><K><A><T><S><E><M><N><T><A><E><D><W><G><L><I><L><D><I><C><D><K><V><G><Q><S><R><T><G><P><K><D><C><L><R><S><I><M><R><R><V><N><H><K><D><P><H><V><A><M><Q><A><L><T><L><L><G><A><C><V><S><N><C><G><K><I><F><H><L><E><V><C><S><R><D><F><A><S><E><V><S><N><V><L><N><K><G><H><P><K><V><C><E><K... | (Microbial infection) Plays an important role in Dengue virus entry.<BOP> | Q92783 |
Q70HW3 | SAMC_HUMAN | Solute carrier family 25 member 26 | Homo | <M><D><R><P><G><F><V><A><A><L><V><A><G><G><V><A><G><V><S><V><D><L><I><L><F><P><L><D><T><I><K><T><R><L><Q><S><P><Q><G><F><S><K><A><G><G><F><H><G><I><Y><A><G><V><P><S><A><A><I><G><S><F><P><N><A><A><A><F><F><I><T><Y><E><Y><V><K><W><F><L><H><A><D><S><S><S><Y><L><T><P><M><K><H><M><L><A><A><S><A><G><E><V><V><A><C><L><I><R><V... | Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.<BOP> | Q70HW3 |
P10606 | COX5B_HUMAN | Cytochrome c oxidase polypeptide Vb | Homo | <M><A><S><R><L><L><R><G><A><G><T><L><A><A><Q><A><L><R><A><R><G><P><S><G><A><A><A><M><R><S><M><A><S><G><G><G><V><P><T><D><E><E><Q><A><T><G><L><E><R><E><I><M><L><A><A><K><K><G><L><D><P><Y><N><V><L><A><P><K><G><A><S><G><T><R><E><D><P><N><L><V><P><S><I><S><N><K><R><I><V><G><C><I><C><E><E><D><N><T><S><V><V><W><F><W><L><H><K... | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII... | P10606 |
P42224 | STAT1_HUMAN | Transcription factor ISGF-3 components p91/p84 | Homo | <M><S><Q><W><Y><E><L><Q><Q><L><D><S><K><F><L><E><Q><V><H><Q><L><Y><D><D><S><F><P><M><E><I><R><Q><Y><L><A><Q><W><L><E><K><Q><D><W><E><H><A><A><N><D><V><S><F><A><T><I><R><F><H><D><L><L><S><Q><L><D><D><Q><Y><S><R><F><S><L><E><N><N><F><L><L><Q><H><N><I><R><K><S><K><R><N><L><Q><D><N><F><Q><E><D><P><I><Q><M><S><M><I><I><Y><S... | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 ... | P42224 |
Q8TAV3 | CP2W1_HUMAN | CYPIIW1 | Homo | <M><A><L><L><L><L><L><F><L><G><L><L><G><L><W><G><L><L><C><A><C><A><Q><D><P><S><P><A><A><R><W><P><P><G><P><R><P><L><P><L><V><G><N><L><H><L><L><R><L><S><Q><Q><D><R><S><L><M><E><L><S><E><R><Y><G><P><V><F><T><V><H><L><G><R><Q><K><T><V><V><L><T><G><F><E><A><V><K><E><A><L><A><G><P><G><Q><E><L><A><D><R><P><P><I><A><I><F><Q><L... | A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism . Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retina... | Q8TAV3 |
P09960 | LKHA4_HUMAN | Tripeptide aminopeptidase LTA4H | Homo | <M><P><E><I><V><D><T><C><S><L><A><S><P><A><S><V><C><R><T><K><H><L><H><L><R><C><S><V><D><F><T><R><R><T><L><T><G><T><A><A><L><T><V><Q><S><Q><E><D><N><L><R><S><L><V><L><D><T><K><D><L><T><I><E><K><V><V><I><N><G><Q><E><V><K><Y><A><L><G><E><R><Q><S><Y><K><G><S><P><M><E><I><S><L><P><I><A><L><S><K><N><Q><E><I><V><I><E><I><S><F... | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) . Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synt... | P09960 |
Q92565 | RPGF5_HUMAN | Related to Epac | Homo | <M><G><S><S><R><L><R><V><F><D><P><H><L><E><R><K><D><S><A><A><A><L><S><D><R><E><L><P><L><P><T><F><D><V><P><Y><F><K><Y><I><D><E><E><D><E><D><D><E><W><S><S><R><S><Q><S><S><T><E><D><D><S><V><D><S><L><L><S><D><R><Y><V><V><V><S><G><T><P><E><K><I><L><E><H><L><L><N><D><L><H><L><E><E><V><Q><D><K><E><T><E><T><L><L><D><D><F><L><L... | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.<BOP> | Q92565 |
Q9Y573 | IPP_HUMAN | Kelch-like protein 27 | Homo | <M><A><N><E><D><C><P><K><A><A><D><S><P><F><S><S><D><K><H><A><Q><L><I><L><A><Q><I><N><K><M><R><N><G><Q><H><F><C><D><V><Q><L><Q><V><G><Q><E><S><F><K><A><H><R><L><V><L><A><A><S><S><P><Y><F><A><A><L><F><T><G><G><M><K><E><S><S><K><D><V><V><P><I><L><G><I><E><A><G><I><F><Q><I><L><L><D><F><I><Y><T><G><I><V><N><I><G><V><N><N><V... | May play a role in organizing the actin cytoskeleton.<BOP> | Q9Y573 |
P58004 | SESN2_HUMAN | Hypoxia-induced gene | Homo | <M><I><V><A><D><S><E><C><R><A><E><L><K><D><Y><L><R><F><A><P><G><G><V><G><D><S><G><P><G><E><E><Q><R><E><S><R><A><R><R><G><P><R><G><P><S><A><F><I><P><V><E><E><V><L><R><E><G><A><E><S><L><E><Q><H><L><G><L><E><A><L><M><S><S><G><R><V><D><N><L><A><V><V><M><G><L><H><P><D><Y><F><T><S><F><W><R><L><H><Y><L><L><L><H><T><D><G><P><L... | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex . In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling p... | P58004 |
Q6UVJ0 | SAS6_HUMAN | Spindle assembly abnormal protein 6 homolog | Homo | <M><S><Q><V><L><F><H><Q><L><V><P><L><Q><V><K><C><K><D><C><E><E><R><R><V><S><I><R><M><S><I><E><L><Q><S><V><S><N><P><V><H><R><K><D><L><V><I><R><L><T><D><D><T><D><P><F><F><L><Y><N><L><V><I><S><E><E><D><F><Q><S><L><K><F><Q><Q><G><L><L><V><D><F><L><A><F><P><Q><K><F><I><D><L><L><Q><Q><C><T><Q><E><H><A><K><E><I><P><R><F><L><L... | Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing c... | Q6UVJ0 |
Q8NCT3 | MACA2_HUMAN | Putative tyrosine carboxypeptidase MATCAP2 | Homo | <M><A><G><C><T><R><K><L><T><H><L><R><K><R><I><H><R><P><R><R><R><T><T><R><R><W><K><R><W><F><K><F><R><K><R><K><G><E><K><R><P><R><P><N><H><K><A><V><A><R><R><A><K><L><K><F><S><T><S><E><K><L><H><W><P><E><Q><E><L><A><K><K><S><I><L><N><A><E><D><S><L><I><I><D><N><K><R><S><I><S><H><L><S><S><G><V><L><K><D><I><F><T><T><G><T><S><S... | Putative tyrosine carboxypeptidase.<BOP> | Q8NCT3 |
Q8IUE1 | TF2LX_HUMAN | TGIF-like on the X | Homo | <M><E><A><A><A><D><G><P><A><E><T><Q><S><P><V><E><K><D><S><P><A><K><T><Q><S><P><A><Q><D><T><S><I><M><S><R><N><N><A><D><T><G><R><V><L><A><L><P><E><H><K><K><K><R><K><G><N><L><P><A><E><S><V><K><I><L><R><D><W><M><Y><K><H><R><F><K><A><Y><P><S><E><E><E><K><Q><M><L><S><E><K><T><N><L><S><L><L><Q><I><S><N><W><F><I><N><A><R><R><R... | May have a transcription role in testis.<BOP> | Q8IUE1 |
P03956 | MMP1_HUMAN | 27 kDa interstitial collagenase | Homo | <M><H><S><F><P><P><L><L><L><L><L><F><W><G><V><V><S><H><S><F><P><A><T><L><E><T><Q><E><Q><D><V><D><L><V><Q><K><Y><L><E><K><Y><Y><N><L><K><N><D><G><R><Q><V><E><K><R><R><N><S><G><P><V><V><E><K><L><K><Q><M><Q><E><F><F><G><L><K><V><T><G><K><P><D><A><E><T><L><K><V><M><K><Q><P><R><C><G><V><P><D><V><A><Q><F><V><L><T><E><G><N><P... | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X . In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity .<BOP> | P03956 |
O75462 | CRLF1_HUMAN | ZcytoR5 | Homo | <M><P><A><G><R><R><G><P><A><A><Q><S><A><R><R><P><P><P><L><L><P><L><L><L><L><L><C><V><L><G><A><P><R><A><G><S><G><A><H><T><A><V><I><S><P><Q><D><P><T><L><L><I><G><S><S><L><L><A><T><C><S><V><H><G><D><P><P><G><A><T><A><E><G><L><Y><W><T><L><N><G><R><R><L><P><P><E><L><S><R><V><L><N><A><S><T><L><A><L><A><L><A><N><L><N><G><S><R... | In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.<BOP> | O75462 |
A0A075B6S0 | TRGJ1_HUMAN | T cell receptor gamma joining 1 | Homo | <N><Y><Y><K><K><L><F><G><S><G><T><T><L><V><V><T> | J region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids present... | A0A075B6S0 |
Q9BY21 | GPR87_HUMAN | G-protein coupled receptor 95 | Homo | <M><G><F><N><L><T><L><A><K><L><P><N><N><E><L><H><G><Q><E><S><H><N><S><G><N><R><S><D><G><P><G><K><N><T><T><L><H><N><E><F><D><T><I><V><L><P><V><L><Y><L><I><I><F><V><A><S><I><L><L><N><G><L><A><V><W><I><F><F><H><I><R><N><K><T><S><F><I><F><Y><L><K><N><I><V><V><A><D><L><I><M><T><L><T><F><P><F><R><I><V><H><D><A><G><F><G><P><W... | Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.<BOP> | Q9BY21 |
Q9H707 | ZN552_HUMAN | Zinc finger protein 552 | Homo | <M><A><A><A><A><L><R><F><P><V><Q><G><T><V><T><F><E><D><V><A><V><K><F><T><Q><E><E><W><N><L><L><S><E><A><Q><R><C><L><Y><R><D><V><T><L><E><N><L><A><L><M><S><S><L><G><C><W><C><G><V><E><D><E><A><A><P><S><K><Q><S><I><Y><I><Q><R><E><T><Q><V><R><T><P><M><A><G><V><S><P><K><K><A><H><P><C><E><M><C><G><P><I><L><G><D><I><L><H><V><A... | May be involved in transcriptional regulation.<BOP> | Q9H707 |
P47992 | XCL1_HUMAN | XC chemokine ligand 1 | Homo | <M><R><L><L><I><L><A><L><L><G><I><C><S><L><T><A><Y><I><V><E><G><V><G><S><E><V><S><D><K><R><T><C><V><S><L><T><T><Q><R><L><P><V><S><R><I><K><T><Y><T><I><T><E><G><S><L><R><A><V><I><F><I><T><K><R><G><L><K><V><C><A><D><P><Q><A><T><W><V><R><D><V><V><R><S><M><D><R><K><S><N><T><R><N><N><M><I><Q><T><K><P><T><G><T><Q><Q><S><T><N... | Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.<BOP> | P47992 |
Q01546 | K22O_HUMAN | Type-II keratin Kb9 | Homo | <M><N><R><Q><V><C><K><K><S><F><S><G><R><S><Q><G><F><S><G><R><S><A><V><V><S><G><S><S><R><M><S><C><V><A><R><S><G><G><A><G><G><G><A><C><G><F><R><S><G><A><G><S><F><G><S><R><S><L><Y><N><L><G><S><N><K><S><I><S><I><S><V><A><A><G><S><S><R><A><G><G><F><G><G><G><R><S><S><C><G><F><A><G><G><Y><G><G><G><F><G><G><S><Y><G><G><G><F><G... | Probably contributes to terminal cornification.<BOP> | Q01546 |
Q9H5V9 | STEEP_HUMAN | STING ER exit protein | Homo | <M><P><K><V><V><S><R><S><V><V><C><S><D><T><R><D><R><E><E><Y><D><D><G><E><K><P><L><H><V><Y><Y><C><L><C><G><Q><M><V><L><V><L><D><C><Q><L><E><K><L><P><M><R><P><R><D><R><S><R><V><I><D><A><A><K><H><A><H><K><F><C><N><T><E><D><E><E><T><M><Y><L><R><R><P><E><G><I><E><R><Q><Y><R><K><K><C><A><K><C><G><L><P><L><F><Y><Q><S><Q><P><K... | Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport . Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers .<BOP> | Q9H5V9 |
Q9Y587 | AP4S1_HUMAN | Sigma-4-adaptin | Homo | <M><I><K><F><F><L><M><V><N><K><Q><G><Q><T><R><L><S><K><Y><Y><E><H><V><D><I><N><K><R><T><L><L><E><T><E><V><I><K><S><C><L><S><R><S><N><E><Q><C><S><F><I><E><Y><K><D><F><K><L><I><Y><R><Q><Y><A><A><L><F><I><V><V><G><V><N><D><T><E><N><E><M><A><I><Y><E><F><I><H><N><F><V><E><V><L><D><E><Y><F><S><R><V><S><E><L><D><I><M><F><N><L... | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways . AP-4 forms a non clathrin-associated coat on vesicles departing the trans-... | Q9Y587 |
O15264 | MK13_HUMAN | Stress-activated protein kinase 4 | Homo | <M><S><L><I><R><K><K><G><F><Y><K><Q><D><V><N><K><T><A><W><E><L><P><K><T><Y><V><S><P><T><H><V><G><S><G><A><Y><G><S><V><C><S><A><I><D><K><R><S><G><E><K><V><A><I><K><K><L><S><R><P><F><Q><S><E><I><F><A><K><R><A><Y><R><E><L><L><L><L><K><H><M><Q><H><E><N><V><I><G><L><L><D><V><F><T><P><A><S><S><L><R><N><F><Y><D><F><Y><L><V><M... | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activ... | O15264 |
P04839 | CY24B_HUMAN | p22 phagocyte B-cytochrome | Homo | <M><G><N><W><A><V><N><E><G><L><S><I><F><V><I><L><V><W><L><G><L><N><V><F><L><F><V><W><Y><Y><R><V><Y><D><I><P><P><K><F><F><Y><T><R><K><L><L><G><S><A><L><A><L><A><R><A><P><A><A><C><L><N><F><N><C><M><L><I><L><L><P><V><C><R><N><L><L><S><F><L><R><G><S><S><A><C><C><S><T><R><V><R><R><Q><L><D><R><N><L><T><F><H><K><M><V><A><W><M... | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that media... | P04839 |
Q9BUM1 | G6PC3_HUMAN | Ubiquitous glucose-6-phosphatase catalytic subunit-related protein | Homo | <M><E><S><T><L><G><A><G><I><V><I><A><E><A><L><Q><N><Q><L><A><W><L><E><N><V><W><L><W><I><T><F><L><G><D><P><K><I><L><F><L><F><Y><F><P><A><A><Y><Y><A><S><R><R><V><G><I><A><V><L><W><I><S><L><I><T><E><W><L><N><L><I><F><K><W><F><L><F><G><D><R><P><F><W><W><V><H><E><S><G><Y><Y><S><Q><A><P><A><Q><V><H><Q><F><P><S><S><C><E><T><G... | Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.<BOP> | Q9BUM1 |
P28360 | MSX1_HUMAN | Msh homeobox 1-like protein | Homo | <M><A><P><A><A><D><M><T><S><L><P><L><G><V><K><V><E><D><S><A><F><G><K><P><A><G><G><G><A><G><Q><A><P><S><A><A><A><A><T><A><A><A><M><G><A><D><E><E><G><A><K><P><K><V><S><P><S><L><L><P><F><S><V><E><A><L><M><A><D><H><R><K><P><G><A><K><E><S><A><L><A><P><S><E><G><V><Q><A><A><G><G><S><A><Q><P><L><G><V><P><P><G><S><L><G><A><P><D... | Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.<BOP> | P28360 |
A8K855 | EFCB7_HUMAN | EF-hand calcium-binding domain-containing protein 7 | Homo | <M><A><I><S><P><R><S><D><A><T><F><S><S><Q><K><S><T><P><S><E><S><P><R><T><K><K><F><P><L><T><E><E><E><I><F><Y><M><N><C><R><A><A><Y><L><T><V><F><K><S><S><L><E><N><I><I><S><K><D><Q><L><Y><L><A><L><Q><H><A><G><R><N><P><S><Q><K><T><I><N><K><Y><W><T><P><Q><T><A><K><L><N><F><D><D><F><C><I><I><L><R><K><E><K><P><T><S><K><A><E><L... | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia.<BOP> | A8K855 |
Q8TAP9 | MPLKI_HUMAN | TTD non-photosensitive 1 protein | Homo | <M><Q><R><Q><N><F><R><P><P><T><P><P><Y><P><G><P><G><G><G><G><W><G><S><G><S><S><F><R><G><T><P><G><G><G><G><P><R><P><P><S><P><R><D><G><Y><G><S><P><H><H><T><P><P><Y><G><P><R><S><R><P><Y><G><S><S><H><S><P><R><H><G><G><S><F><P><G><G><R><F><G><S><P><S><P><G><G><Y><P><G><S><Y><S><R><S><P><A><G><S><Q><Q><Q><F><G><Y><S><P><G><Q... | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.<BOP> | Q8TAP9 |
Q96GR4 | ZDH12_HUMAN | Zinc finger protein 400 | Homo | <M><A><P><W><A><L><L><S><P><G><V><L><V><R><T><G><H><T><V><L><T><W><G><I><T><L><V><L><F><L><H><D><T><E><L><R><Q><W><E><E><Q><G><E><L><L><L><P><L><T><F><L><L><L><V><L><G><S><L><L><L><Y><L><A><V><S><L><M><D><P><G><Y><V><N><V><Q><P><Q><P><Q><E><E><L><K><E><E><Q><T><A><M><V><P><P><A><I><P><L><R><R><C><R><Y><C><L><V><L><Q><P... | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmissi... | Q96GR4 |
P06331 | HV434_HUMAN | Ig heavy chain V-II region ARH-77 | Homo | <M><D><L><L><H><K><N><M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><V><Q><L><Q><Q><W><G><A><G><L><L><K><P><S><E><T><L><S><L><T><C><A><V><Y><G><G><S><F><S><G><Y><Y><W><S><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><E><I><N><H><S><G><S><T><N><Y><N><P><S><L><K><S><R><V><T><I><S><V><D><T><S><K><N><Q><F><S><L><K... | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P06331 |
D6RA61 | U17LM_HUMAN | Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 | Homo | <M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y... | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP> | D6RA61 |
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