accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P32969 | RL9_HUMAN | Large ribosomal subunit protein uL6 | Homo | <M><K><T><I><L><S><N><Q><T><V><D><I><P><E><N><V><D><I><T><L><K><G><R><T><V><I><V><K><G><P><R><G><T><L><R><R><D><F><N><H><I><N><V><E><L><S><L><L><G><K><K><K><K><R><L><R><V><D><K><W><W><G><N><R><K><E><L><A><T><V><R><T><I><C><S><H><V><Q><N><M><I><K><G><V><T><L><G><F><R><Y><K><M><R><S><V><Y><A><H><F><P><I><N><V><V><I><Q><E><N><G><S><L><V><E><I><R><N><F><L><G><E><K><Y><I><R><R><V><R><M><R><P><G><V><A><C><S><V><S><Q><A><Q><K><D><E><L><I><L><E><G><N><D><I><E><L><V><S><N><S><A><A><L><I><Q><Q><A><T><T><V><K><N><K><D><I><R><K><F><L><D><G><I><Y><V><S><E><K><G><T><V><Q><Q><A><D><E> | Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP> | P32969 |
P49336 | CDK8_HUMAN | Protein kinase K35 | Homo | <M><D><Y><D><F><K><V><K><L><S><S><E><R><E><R><V><E><D><L><F><E><Y><E><G><C><K><V><G><R><G><T><Y><G><H><V><Y><K><A><K><R><K><D><G><K><D><D><K><D><Y><A><L><K><Q><I><E><G><T><G><I><S><M><S><A><C><R><E><I><A><L><L><R><E><L><K><H><P><N><V><I><S><L><Q><K><V><F><L><S><H><A><D><R><K><V><W><L><L><F><D><Y><A><E><H><D><L><W><H><I><I><K><F><H><R><A><S><K><A><N><K><K><P><V><Q><L><P><R><G><M><V><K><S><L><L><Y><Q><I><L><D><G><I><H><Y><L><H><A><N><W><V><L><H><R><D><L><K><P><A><N><I><L><V><M><G><E><G><P><E><R><G><R><V><K><I><A><D><M><G><F><A><R><L><F><N><S><P><L><K><P><L><A><D><L><D><P><V><V><V><T><F><W><Y><R><A><P><E><L><L><L><G><A><R><H><Y><T><K><A><I><D><I><W><A><I><G><C><I><F><A><E><L><L><T><S><E><P><I><F><H><C><R><Q><E><D><I><K><T><S><N><P><Y><H><H><D><Q><L><D><R><I><F><N><V><M><G><F><P><A><D><K><D><W><E><D><I><K><K><M><P><E><H><S><T><L><M><K><D><F><R><R><N><T><Y><T><N><C><S><L><I><K><Y><M><E><K><H><K><V><K><P><D><S><K><A><F><H><L><L><Q><K><L><L><T><M><D><P><I><K><R><I><T><S><E><Q><A><M><Q><D><P><Y><F><L><E><D><P><L><P><T><S><D><V><F><A><G><C><Q><I><P><Y><P><K><R><E><F><L><T><E><E><E><P><D><D><K><G><D><K><K><N><Q><Q><Q><Q><Q><G><N><N><H><T><N><G><T><G><H><P><G><N><Q><D><S><S><H><T><Q><G><P><P><L><K><K><V><R><V><V><P><P><T><T><T><S><G><G><L><I><M><T><S><D><Y><Q><R><S><N><P><H><A><A><Y><P><N><P><G><P><S><T><S><Q><P><Q><S><S><M><G><Y><S><A><T><S><Q><Q><P><P><Q><Y><S><H><Q><T><H><R><Y> | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.<BOP> | P49336 |
Q12796 | PNRC1_HUMAN | Protein B4-2 | Homo | <M><T><V><V><S><V><P><Q><R><E><P><L><V><L><G><G><R><L><A><P><L><G><F><S><S><R><G><Y><F><G><A><L><P><M><V><T><T><A><P><P><P><L><P><R><I><P><D><P><R><A><L><P><P><T><L><F><L><P><H><F><L><G><G><D><G><P><C><L><T><P><Q><P><R><A><P><A><A><L><P><N><R><S><L><A><V><A><G><G><T><P><R><A><A><P><K><K><R><R><K><K><K><V><R><A><S><P><A><G><Q><L><P><S><R><F><H><Q><Y><Q><Q><H><R><P><S><L><E><G><G><R><S><P><A><T><G><P><S><G><A><Q><E><V><P><G><P><A><A><A><L><A><P><S><P><A><A><A><A><G><T><E><G><A><S><P><D><L><A><P><L><R><P><A><A><P><G><Q><T><P><L><R><K><E><V><L><K><S><K><M><G><K><S><E><K><I><A><L><P><H><G><Q><L><V><H><G><I><H><L><Y><E><Q><P><K><I><N><R><Q><K><S><K><Y><N><L><P><L><T><K><I><T><S><A><K><R><N><E><N><N><F><W><Q><D><S><V><S><S><D><R><I><Q><K><Q><E><K><K><P><F><K><N><T><E><N><I><K><N><S><H><L><K><K><S><A><F><L><T><E><V><S><Q><K><E><N><Y><A><G><A><K><F><S><D><P><P><S><P><S><V><L><P><K><P><P><S><H><W><M><G><S><T><V><E><N><S><N><Q><N><R><E><L><M><A><V><H><L><K><T><L><L><K><V><Q><T> | Nuclear receptor coactivator. May play a role in signal transduction.<BOP> | Q12796 |
Q8IZN3 | ZDH14_HUMAN | Zinc finger DHHC domain-containing protein 14 | Homo | <M><P><P><G><G><G><G><P><M><K><D><C><E><Y><S><Q><I><S><T><H><S><S><S><P><M><E><S><P><H><K><K><K><K><I><A><A><R><R><K><W><E><V><F><P><G><R><N><K><F><F><C><N><G><R><I><M><M><A><R><Q><T><G><V><F><Y><L><T><L><V><L><I><L><V><T><S><G><L><F><F><A><F><D><C><P><Y><L><A><V><K><I><T><P><A><I><P><A><V><A><G><I><L><F><F><F><V><M><G><T><L><L><R><T><S><F><S><D><P><G><V><L><P><R><A><T><P><D><E><A><A><D><L><E><R><Q><I><D><I><A><N><G><T><S><S><G><G><Y><R><P><P><P><R><T><K><E><V><I><I><N><G><Q><T><V><K><L><K><Y><C><F><T><C><K><I><F><R><P><P><R><A><S><H><C><S><L><C><D><N><C><V><E><R><F><D><H><H><C><P><W><V><G><N><C><V><G><K><R><N><Y><R><F><F><Y><M><F><I><L><S><L><S><F><L><T><V><F><I><F><A><F><V><I><T><H><V><I><L><R><S><Q><Q><T><G><F><L><N><A><L><K><D><S><P><A><S><V><L><E><A><V><V><C><F><F><S><V><W><S><I><V><G><L><S><G><F><H><T><Y><L><I><S><S><N><Q><T><T><N><E><D><I><K><G><S><W><S><N><K><R><G><K><E><N><Y><N><P><Y><S><Y><G><N><I><F><T><N><C><C><V><A><L><C><G><P><I><S><P><S><L><I><D><R><R><G><Y><I><Q><P><D><T><P><Q><P><A><A><P><S><N><G><I><T><M><Y><G><A><T><Q><S><Q><S><D><M><C><D><Q><D><Q><C><I><Q><S><T><K><F><V><L><Q><A><A><A><T><P><L><L><Q><S><E><P><S><L><T><S><D><E><L><H><L><P><G><K><P><G><L><G><T><P><C><A><S><L><T><L><G><P><P><T><P><P><A><S><M><P><N><L><A><E><A><T><L><A><D><V><M><P><R><K><D><E><H><M><G><H><Q><F><L><T><P><D><E><A><P><S><P><P><R><L><L><A><A><G><S><P><L><A><H><S><R><T><M><H><V><L><G><L><A><S><Q><D><S><L><H><E><D><S><V><R><G><L><V><K><L><S><S><V> | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and thereby regulate G protein-coupled receptor signaling . May play a role in cell differentiation and apoptosis .<BOP> | Q8IZN3 |
P52737 | ZN136_HUMAN | Zinc finger protein 136 | Homo | <M><D><S><V><A><F><E><D><V><D><V><N><F><T><Q><E><E><W><A><L><L><D><P><S><Q><K><N><L><Y><R><D><V><M><W><E><T><M><R><N><L><A><S><I><G><K><K><W><K><D><Q><N><I><K><D><H><Y><K><H><R><G><R><N><L><R><S><H><M><L><E><R><L><Y><Q><T><K><D><G><S><Q><R><G><G><I><F><S><Q><F><A><N><Q><N><L><S><K><K><I><P><G><V><K><L><C><E><S><I><V><Y><G><E><V><S><M><G><Q><S><S><L><N><R><H><I><K><D><H><S><G><H><E><P><K><E><Y><Q><E><Y><G><E><K><P><D><T><R><N><Q><C><W><K><P><F><S><S><H><H><S><F><R><T><H><E><I><I><H><T><G><E><K><L><Y><D><C><K><E><C><G><K><T><F><F><S><L><K><R><I><R><R><H><I><I><T><H><S><G><Y><T><P><Y><K><C><K><V><C><G><K><A><F><D><Y><P><S><R><F><R><T><H><E><R><S><H><T><G><E><K><P><Y><E><C><Q><E><C><G><K><A><F><T><C><I><T><S><V><R><R><H><M><I><K><H><T><G><D><G><P><Y><K><C><K><V><C><G><K><P><F><H><S><L><S><S><F><Q><V><H><E><R><I><H><T><G><E><K><P><F><K><C><K><Q><C><G><K><A><F><S><C><S><P><T><L><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><Y><L><P><S><L><R><L><H><E><R><I><H><T><G><E><K><P><F><V><C><K><Q><C><G><K><A><F><R><S><A><S><T><F><Q><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><E><A><F><S><C><I><P><S><M><R><R><H><M><I><K><H><T><G><E><G><P><Y><K><C><K><V><C><G><K><P><F><H><S><L><S><P><F><R><I><H><E><R><T><H><T><G><E><K><P><Y><V><C><K><H><C><G><K><A><F><V><S><S><T><S><I><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><Y><L><N><S><F><R><T><H><E><M><I><H><T><G><E><K><P><F><E><C><K><R><C><G><K><A><F><R><S><S><S><S><F><R><L><H><E><R><T><H><T><G><Q><K><P><Y><H><C><K><E><C><G><K><A><Y><S><C><R><A><S><F><Q><R><H><M><L><T><H><A><E><D><G><P><P><Y><K><C><M><W><E><S><L> | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.<BOP> | P52737 |
Q9HC21 | TPC_HUMAN | Solute carrier family 25 member 19 | Homo | <M><V><G><Y><D><P><K><P><D><G><R><N><N><T><K><F><Q><V><A><V><A><G><S><V><S><G><L><V><T><R><A><L><I><S><P><F><D><V><I><K><I><R><F><Q><L><Q><H><E><R><L><S><R><S><D><P><S><A><K><Y><H><G><I><L><Q><A><S><R><Q><I><L><Q><E><E><G><P><T><A><F><W><K><G><H><V><P><A><Q><I><L><S><I><G><Y><G><A><V><Q><F><L><S><F><E><M><L><T><E><L><V><H><R><G><S><V><Y><D><A><R><E><F><S><V><H><F><V><C><G><G><L><A><A><C><M><A><T><L><T><V><H><P><V><D><V><L><R><T><R><F><A><A><Q><G><E><P><K><V><Y><N><T><L><R><H><A><V><G><T><M><Y><R><S><E><G><P><Q><V><F><Y><K><G><L><A><P><T><L><I><A><I><F><P><Y><A><G><L><Q><F><S><C><Y><S><S><L><K><H><L><Y><K><W><A><I><P><A><E><G><K><K><N><E><N><L><Q><N><L><L><C><G><S><G><A><G><V><I><S><K><T><L><T><Y><P><L><D><L><F><K><K><R><L><Q><V><G><G><F><E><H><A><R><A><A><F><G><Q><V><R><R><Y><K><G><L><M><D><C><A><K><Q><V><L><Q><K><E><G><A><L><G><F><F><K><G><L><S><P><S><L><L><K><A><A><L><S><T><G><F><M><F><F><S><Y><E><F><F><C><N><V><F><H><C><M><N><R><T><A><S><Q><R> | Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.<BOP> | Q9HC21 |
P78330 | SERB_HUMAN | O-phosphoserine phosphohydrolase | Homo | <M><V><S><H><S><E><L><R><K><L><F><Y><S><A><D><A><V><C><F><D><V><D><S><T><V><I><R><E><E><G><I><D><E><L><A><K><I><C><G><V><E><D><A><V><S><E><M><T><R><R><A><M><G><G><A><V><P><F><K><A><A><L><T><E><R><L><A><L><I><Q><P><S><R><E><Q><V><Q><R><L><I><A><E><Q><P><P><H><L><T><P><G><I><R><E><L><V><S><R><L><Q><E><R><N><V><Q><V><F><L><I><S><G><G><F><R><S><I><V><E><H><V><A><S><K><L><N><I><P><A><T><N><V><F><A><N><R><L><K><F><Y><F><N><G><E><Y><A><G><F><D><E><T><Q><P><T><A><E><S><G><G><K><G><K><V><I><K><L><L><K><E><K><F><H><F><K><K><I><I><M><I><G><D><G><A><T><D><M><E><A><C><P><P><A><D><A><F><I><G><F><G><G><N><V><I><R><Q><Q><V><K><D><N><A><K><W><Y><I><T><D><F><V><E><L><L><G><E><L><E><E> | Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine . L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator . May also act on O-phospho-D-serine (Probable).<BOP> | P78330 |
O15318 | RPC7_HUMAN | RNA polymerase III 32 kDa subunit | Homo | <M><A><G><N><K><G><R><G><R><A><A><Y><T><F><N><I><E><A><V><G><F><S><K><G><E><K><L><P><D><V><V><L><K><P><P><P><L><F><P><D><T><D><Y><K><P><V><P><L><K><T><G><E><G><E><E><Y><M><L><A><L><K><Q><E><L><R><E><T><M><K><R><M><P><Y><F><I><E><T><P><E><E><R><Q><D><I><E><R><Y><S><K><R><Y><M><K><V><Y><K><E><E><W><I><P><D><W><R><R><L><P><R><E><M><M><P><R><N><K><C><K><K><A><G><P><K><P><K><K><A><K><D><A><G><K><G><T><P><L><T><N><T><E><D><V><L><K><K><M><E><E><L><E><K><R><G><D><G><E><K><S><D><E><E><N><E><E><K><E><G><S><K><E><K><S><K><E><G><D><D><D><D><D><D><D><A><A><E><Q><E><E><Y><D><E><E><E><Q><E><E><E><N><D><Y><I><N><S><Y><F><E><D><G><D><D><F><G><A><D><S><D><D><N><M><D><E><A><T><Y> | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs . May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway .<BOP> | O15318 |
Q7Z4V5 | HDGR2_HUMAN | Hepatoma-derived growth factor 2 | Homo | <M><P><H><A><F><K><P><G><D><L><V><F><A><K><M><K><G><Y><P><H><W><P><A><R><I><D><D><I><A><D><G><A><V><K><P><P><P><N><K><Y><P><I><F><F><F><G><T><H><E><T><A><F><L><G><P><K><D><L><F><P><Y><D><K><C><K><D><K><Y><G><K><P><N><K><R><K><G><F><N><E><G><L><W><E><I><Q><N><N><P><H><A><S><Y><S><A><P><P><P><V><S><S><S><D><S><E><A><P><E><A><N><P><A><D><G><S><D><A><D><E><D><D><E><D><R><G><V><M><A><V><T><A><V><T><A><T><A><A><S><D><R><M><E><S><D><S><D><S><D><K><S><S><D><N><S><G><L><K><R><K><T><P><A><L><K><M><S><V><S><K><R><A><R><K><A><S><S><D><L><D><Q><A><S><V><S><P><S><E><E><E><N><S><E><S><S><S><E><S><E><K><T><S><D><Q><D><F><T><P><E><K><K><A><A><V><R><A><P><R><R><G><P><L><G><G><R><K><K><K><K><A><P><S><A><S><D><S><D><S><K><A><D><S><D><G><A><K><P><E><P><V><A><M><A><R><S><A><S><S><S><S><S><S><S><S><S><S><D><S><D><V><S><V><K><K><P><P><R><G><R><K><P><A><E><K><P><L><P><K><P><R><G><R><K><P><K><P><E><R><P><P><S><S><S><S><S><D><S><D><S><D><E><V><D><R><I><S><E><W><K><R><R><D><E><A><R><R><R><E><L><E><A><R><R><R><R><E><Q><E><E><E><L><R><R><L><R><E><Q><E><K><E><E><K><E><R><R><R><E><R><A><D><R><G><E><A><E><R><G><S><G><G><S><S><G><D><E><L><R><E><D><D><E><P><V><K><K><R><G><R><K><G><R><G><R><G><P><P><S><S><S><D><S><E><P><E><A><E><L><E><R><E><A><K><K><S><A><K><K><P><Q><S><S><S><T><E><P><A><R><K><P><G><Q><K><E><K><R><V><R><P><E><E><K><Q><Q><A><K><P><V><K><V><E><R><T><R><K><R><S><E><G><F><S><M><D><R><K><V><E><K><K><K><E><P><S><V><E><E><K><L><Q><K><L><H><S><E><I><K><F><A><L><K><V><D><S><P><D><V><K><R><C><L><N><A><L><E><E><L><G><T><L><Q><V><T><S><Q><I><L><Q><K><N><T><D><V><V><A><T><L><K><K><I><R><R><Y><K><A><N><K><D><V><M><E><K><A><A><E><V><Y><T><R><L><K><S><R><V><L><G><P><K><I><E><A><V><Q><K><V><N><K><A><G><M><E><K><E><K><A><E><E><K><L><A><G><E><E><L><A><G><E><E><A><P><Q><E><K><A><E><D><K><P><S><T><D><L><S><A><P><V><N><G><E><A><T><S><Q><K><G><E><S><A><E><D><K><E><H><E><E><G><R><D><S><E><E><G><P><R><C><G><S><S><E><D><L><H><D><S><V><R><E><G><P><D><L><D><R><P><G><S><D><R><Q><E><R><E><R><A><R><G><D><S><E><A><L><D><E><E><S> | Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) . Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters . Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs . Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 . Involved in cellular growth control, through the regulation of cyclin D1 expression .<BOP> | Q7Z4V5 |
P59780 | AP3S2_HUMAN | Sigma-adaptin 3b | Homo | <M><I><Q><A><I><L><V><F><N><N><H><G><K><P><R><L><V><R><F><Y><Q><R><F><P><E><E><I><Q><Q><Q><I><V><R><E><T><F><H><L><V><L><K><R><D><D><N><I><C><N><F><L><E><G><G><S><L><I><G><G><S><D><Y><K><L><I><Y><R><H><Y><A><T><L><Y><F><V><F><C><V><D><S><S><E><S><E><L><G><I><L><D><L><I><Q><V><F><V><E><T><L><D><K><C><F><E><N><V><C><E><L><D><L><I><F><H><M><D><K><V><H><Y><I><L><Q><E><V><V><M><G><G><M><V><L><E><T><N><M><N><E><I><V><A><Q><I><E><A><Q><N><R><L><E><K><S><E><G><G><L><S><A><A><P><A><R><A><V><S><A><V><K><N><I><N><L><P><E><I><P><R><N><I><N><I><G><D><L><N><I><K><V><P><N><L><S><Q><F><V> | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.<BOP> | P59780 |
Q01196 | RUNX1_HUMAN | SL3/AKV core-binding factor alpha B subunit | Homo | <M><R><I><P><V><D><A><S><T><S><R><R><F><T><P><P><S><T><A><L><S><P><G><K><M><S><E><A><L><P><L><G><A><P><D><A><G><A><A><L><A><G><K><L><R><S><G><D><R><S><M><V><E><V><L><A><D><H><P><G><E><L><V><R><T><D><S><P><N><F><L><C><S><V><L><P><T><H><W><R><C><N><K><T><L><P><I><A><F><K><V><V><A><L><G><D><V><P><D><G><T><L><V><T><V><M><A><G><N><D><E><N><Y><S><A><E><L><R><N><A><T><A><A><M><K><N><Q><V><A><R><F><N><D><L><R><F><V><G><R><S><G><R><G><K><S><F><T><L><T><I><T><V><F><T><N><P><P><Q><V><A><T><Y><H><R><A><I><K><I><T><V><D><G><P><R><E><P><R><R><H><R><Q><K><L><D><D><Q><T><K><P><G><S><L><S><F><S><E><R><L><S><E><L><E><Q><L><R><R><T><A><M><R><V><S><P><H><H><P><A><P><T><P><N><P><R><A><S><L><N><H><S><T><A><F><N><P><Q><P><Q><S><Q><M><Q><D><T><R><Q><I><Q><P><S><P><P><W><S><Y><D><Q><S><Y><Q><Y><L><G><S><I><A><S><P><S><V><H><P><A><T><P><I><S><P><G><R><A><S><G><M><T><T><L><S><A><E><L><S><S><R><L><S><T><A><P><D><L><T><A><F><S><D><P><R><Q><F><P><A><L><P><S><I><S><D><P><R><M><H><Y><P><G><A><F><T><Y><S><P><T><P><V><T><S><G><I><G><I><G><M><S><A><M><G><S><A><T><R><Y><H><T><Y><L><P><P><P><Y><P><G><S><S><Q><A><Q><G><G><P><F><Q><A><S><S><P><S><Y><H><L><Y><Y><G><A><S><A><G><S><Y><Q><F><S><M><V><G><G><E><R><S><P><P><R><I><L><P><P><C><T><N><A><S><T><G><S><A><L><L><N><P><S><L><P><N><Q><S><D><V><V><E><A><E><G><S><H><S><N><S><P><T><N><M><A><P><S><A><R><L><E><E><A><V><W><R><P><Y> | Isoform AML-1L interferes with the transactivation activity of RUNX1.<BOP> | Q01196 |
Q16778 | H2B2E_HUMAN | Histone H2B.q | Homo | <M><P><E><P><A><K><S><A><P><A><P><K><K><G><S><K><K><A><V><T><K><A><Q><K><K><D><G><K><K><R><K><R><S><R><K><E><S><Y><S><I><Y><V><Y><K><V><L><K><Q><V><H><P><D><T><G><I><S><S><K><A><M><G><I><M><N><S><F><V><N><D><I><F><E><R><I><A><G><E><A><S><R><L><A><H><Y><N><K><R><S><T><I><T><S><R><E><I><Q><T><A><V><R><L><L><L><P><G><E><L><A><K><H><A><V><S><E><G><T><K><A><V><T><K><Y><T><S><S><K> | Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<BOP> | Q16778 |
A0A0B4J272 | TVA24_HUMAN | T cell receptor alpha variable 24 | Homo | <M><E><K><N><P><L><A><A><P><L><L><I><L><W><F><H><L><D><C><V><S><S><I><L><N><V><E><Q><S><P><Q><S><L><H><V><Q><E><G><D><S><T><N><F><T><C><S><F><P><S><S><N><F><Y><A><L><H><W><Y><R><W><E><T><A><K><S><P><E><A><L><F><V><M><T><L><N><G><D><E><K><K><K><G><R><I><S><A><T><L><N><T><K><E><G><Y><S><Y><L><Y><I><K><G><S><Q><P><E><D><S><A><T><Y><L><C><A><F> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0B4J272 |
Q5TZ20 | OR2G6_HUMAN | Olfactory receptor 2G6 | Homo | <M><E><E><T><N><N><S><S><E><K><G><F><L><L><L><G><F><S><D><Q><P><Q><L><E><R><F><L><F><A><I><I><L><Y><F><Y><V><L><S><L><L><G><N><T><A><L><I><L><V><C><C><L><D><S><R><L><H><T><P><M><Y><F><F><L><S><N><L><S><C><V><D><I><C><F><T><T><S><V><A><P><Q><L><L><V><T><M><N><K><K><D><K><T><M><S><Y><G><G><C><V><A><Q><L><Y><V><A><M><G><L><G><S><S><E><C><I><L><L><A><V><M><A><Y><D><R><Y><A><A><V><C><R><P><L><R><Y><I><A><I><M><H><P><R><F><C><A><S><L><A><G><G><A><W><L><S><G><L><I><T><S><L><I><Q><C><S><L><T><V><Q><L><P><L><C><G><H><R><T><L><D><H><I><F><C><E><V><P><V><L><I><K><L><A><C><V><D><T><T><F><N><E><A><E><L><F><V><A><S><V><V><F><L><I><V><P><V><L><L><I><L><V><S><Y><G><F><I><T><Q><A><V><L><R><I><K><S><A><A><G><R><Q><K><A><F><G><T><C><S><S><H><L><V><V><V><I><I><F><Y><G><T><I><I><F><M><Y><L><Q><P><A><N><R><R><S><K><N><Q><G><K><F><V><S><L><F><Y><T><I><V><T><P><L><L><N><P><I><I><Y><T><L><R><N><K><D><V><K><G><A><L><R><T><L><I><L><G><S><A><A><G><Q><S><H><K><D> | Odorant receptor.<BOP> | Q5TZ20 |
Q6P587 | FAHD1_HUMAN | YisK-like protein | Homo | <M><G><I><M><A><A><S><R><P><L><S><R><F><W><E><W><G><K><N><I><V><C><V><G><R><N><Y><A><D><H><V><R><E><M><R><S><A><V><L><S><E><P><V><L><F><L><K><P><S><T><A><Y><A><P><E><G><S><P><I><L><M><P><A><Y><T><R><N><L><H><H><E><L><E><L><G><V><V><M><G><K><R><C><R><A><V><P><E><A><A><A><M><D><Y><V><G><G><Y><A><L><C><L><D><M><T><A><R><D><V><Q><D><E><C><K><K><K><G><L><P><W><T><L><A><K><S><F><T><A><S><C><P><V><S><A><F><V><P><K><E><K><I><P><D><P><H><K><L><K><L><W><L><K><V><N><G><E><L><R><Q><E><G><E><T><S><S><M><I><F><S><I><P><Y><I><I><S><Y><V><S><K><I><I><T><L><E><E><G><D><I><I><L><T><G><T><P><K><G><V><G><P><V><K><E><N><D><E><I><E><A><G><I><H><G><L><V><S><M><T><F><K><V><E><K><P><E><Y> | Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro . Also has oxaloacetate decarboxylase activity .<BOP> | Q6P587 |
O75820 | ZN189_HUMAN | Zinc finger protein 189 | Homo | <M><A><S><P><S><P><P><P><E><S><K><G><L><L><T><F><E><D><V><A><V><F><F><T><Q><E><E><W><D><Y><L><D><P><A><Q><R><S><L><Y><K><D><V><M><M><E><N><Y><G><N><L><V><S><L><D><V><L><N><R><D><K><D><E><E><P><T><V><K><Q><E><I><E><E><I><E><E><E><V><E><P><Q><G><V><I><V><T><R><I><K><S><E><I><D><Q><D><P><M><G><R><E><T><F><E><L><V><G><R><L><D><K><Q><R><G><I><F><L><W><E><I><P><R><E><S><L><T><Q><E><Q><R><M><F><R><E><N><T><N><I><I><R><K><R><P><N><S><E><E><K><C><H><K><C><E><E><C><G><K><G><F><V><R><K><A><H><F><I><Q><H><Q><R><V><H><T><G><E><K><P><F><Q><C><N><E><C><G><K><S><F><S><R><S><S><F><V><I><E><H><Q><R><I><H><T><G><E><R><P><Y><E><C><N><Y><C><G><K><T><F><S><V><S><S><T><L><I><R><H><Q><R><I><H><T><G><E><R><P><Y><Q><C><N><Q><C><K><Q><S><F><S><Q><R><R><S><L><V><K><H><Q><R><I><H><T><G><E><K><P><H><K><C><S><D><C><G><K><A><F><S><W><K><S><H><L><I><E><H><Q><R><T><H><T><G><E><K><P><Y><H><C><T><K><C><K><K><S><F><S><R><N><S><L><L><V><E><H><Q><R><I><H><T><G><E><R><P><H><K><C><G><E><C><G><K><A><F><R><L><S><T><Y><L><I><Q><H><Q><K><I><H><T><G><E><K><P><F><L><C><I><E><C><G><K><S><F><S><R><S><S><F><L><I><E><H><Q><R><I><H><T><G><E><R><P><Y><Q><C><K><E><C><G><K><S><F><S><Q><L><C><N><L><T><R><H><Q><R><I><H><T><G><D><K><P><H><K><C><E><E><C><G><K><A><F><S><R><S><S><G><L><I><Q><H><Q><R><I><H><T><R><E><K><T><Y><P><Y><N><E><T><K><E><S><F><D><P><N><C><S><L><V><I><Q><Q><E><V><Y><P><K><E><K><S><Y><K><C><D><E><C><G><K><T><F><S><V><S><A><H><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><L><C><T><V><C><G><K><S><F><S><R><S><S><F><L><I><E><H><Q><R><I><H><T><G><E><R><P><Y><L><C><R><Q><C><G><K><S><F><S><Q><L><C><N><L><I><R><H><Q><G><V><H><T><G><N><K><P><H><K><C><D><E><C><G><K><A><F><S><R><N><S><G><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><E><K><C><D><K><S><F><S><Q><Q><R><S><L><V><N><H><Q><K><I><H><A><E><V><K><T><Q><E><T><H><E><C><D><A><C><G><E><A><F><N><C><R><I><S><L><I><Q><H><Q><K><L><H><T><A><W><M><Q> | May be involved in transcriptional regulation.<BOP> | O75820 |
Q96KK3 | KCNS1_HUMAN | Voltage-gated potassium channel subunit Kv9.1 | Homo | <M><L><M><L><L><V><R><G><T><H><Y><E><N><L><R><S><K><V><V><L><P><T><P><L><G><G><R><S><T><E><T><F><V><S><E><F><P><G><P><D><T><G><I><R><W><R><R><S><D><E><A><L><R><V><N><V><G><G><V><R><R><Q><L><S><A><R><A><L><A><R><F><P><G><T><R><L><G><R><L><Q><A><A><A><S><E><E><Q><A><R><R><L><C><D><D><Y><D><E><A><A><R><E><F><Y><F><D><R><H><P><G><F><F><L><S><L><L><H><F><Y><R><T><G><H><L><H><V><L><D><E><L><C><V><F><A><F><G><Q><E><A><D><Y><W><G><L><G><E><N><A><L><A><A><C><C><R><A><R><Y><L><E><R><R><L><T><Q><P><H><A><W><D><E><D><S><D><T><P><S><S><V><D><P><C><P><D><E><I><S><D><V><Q><R><E><L><A><R><Y><G><A><A><R><C><G><R><L><R><R><R><L><W><L><T><M><E><N><P><G><Y><S><L><P><S><K><L><F><S><C><V><S><I><S><V><V><L><A><S><I><A><A><M><C><I><H><S><L><P><E><Y><Q><A><R><E><A><A><A><A><V><A><A><V><A><A><G><R><S><P><E><G><V><R><D><D><P><V><L><R><R><L><E><Y><F><C><I><A><W><F><S><F><E><V><S><S><R><L><L><L><A><P><S><T><R><N><F><F><C><H><P><L><N><L><I><D><I><V><S><V><L><P><F><Y><L><T><L><L><A><G><V><A><L><G><D><Q><G><G><K><E><F><G><H><L><G><K><V><V><Q><V><F><R><L><M><R><I><F><R><V><L><K><L><A><R><H><S><T><G><L><R><S><L><G><A><T><L><K><H><S><Y><R><E><V><G><I><L><L><L><Y><L><A><V><G><V><S><V><F><S><G><V><A><Y><T><A><E><K><E><E><D><V><G><F><N><T><I><P><A><C><W><W><W><G><T><V><S><M><T><T><V><G><Y><G><D><V><V><P><V><T><V><A><G><K><L><A><A><S><G><C><I><L><G><G><I><L><V><V><A><L><P><I><T><I><I><F><N><K><F><S><H><F><Y><R><R><Q><K><A><L><E><A><A><V><R><N><S><N><H><Q><E><F><E><D><L><L><S><S><I><D><G><V><S><E><A><S><L><E><T><S><R><E><T><S><Q><E><G><Q><S><A><D><L><E><S><Q><A><P><S><E><P><P><H><P><Q><M><Y> | Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 .<BOP> | Q96KK3 |
Q9H773 | DCTP1_HUMAN | XTP3-transactivated gene A protein | Homo | <M><S><V><A><G><G><E><I><R><G><D><T><G><G><E><D><T><A><A><P><G><R><F><S><F><S><P><E><P><T><L><E><D><I><R><R><L><H><A><E><F><A><A><E><R><D><W><E><Q><F><H><Q><P><R><N><L><L><L><A><L><V><G><E><V><G><E><L><A><E><L><F><Q><W><K><T><D><G><E><P><G><P><Q><G><W><S><P><R><E><R><A><A><L><Q><E><E><L><S><D><V><L><I><Y><L><V><A><L><A><A><R><C><R><V><D><L><P><L><A><V><L><S><K><M><D><I><N><R><R><R><Y><P><A><H><L><A><R><S><S><S><R><K><Y><T><E><L><P><H><G><A><I><S><E><D><Q><A><V><G><P><A><D><I><P><C><D><S><T><G><Q><T><S><T> | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.<BOP> | Q9H773 |
Q9BXS0 | COPA1_HUMAN | Collagen-like Alzheimer amyloid plaque component | Homo | <M><L><L><K><K><H><A><G><K><G><G><G><R><E><P><R><S><E><D><P><T><P><A><E><Q><H><C><A><R><T><M><P><P><C><A><V><L><A><A><L><L><S><V><V><A><V><V><S><C><L><Y><L><G><V><K><T><N><D><L><Q><A><R><I><A><A><L><E><S><A><K><G><A><P><S><I><H><L><L><P><D><T><L><D><H><L><K><T><M><V><Q><E><K><V><E><R><L><L><A><Q><K><S><Y><E><H><M><A><K><I><R><I><A><R><E><A><P><S><E><C><N><C><P><A><G><P><P><G><K><R><G><K><R><G><R><R><G><E><S><G><P><P><G><Q><P><G><P><Q><G><P><P><G><P><K><G><D><K><G><E><Q><G><D><Q><G><P><R><M><V><F><P><K><I><N><H><G><F><L><S><A><D><Q><Q><L><I><K><R><R><L><I><K><G><D><Q><G><Q><A><G><P><P><G><P><P><G><P><P><G><P><R><G><P><P><G><D><T><G><K><D><G><P><R><G><M><P><G><V><P><G><E><P><G><K><P><G><E><Q><G><L><M><G><P><L><G><P><P><G><Q><K><G><S><I><G><A><P><G><I><P><G><M><N><G><Q><K><G><E><P><G><L><P><G><A><V><G><Q><N><G><I><P><G><P><K><G><E><P><G><E><Q><G><E><K><G><D><A><G><E><N><G><P><K><G><D><T><G><E><K><G><D><P><G><S><S><A><A><G><I><K><G><E><P><G><E><S><G><R><P><G><Q><K><G><E><P><G><L><P><G><L><P><G><L><P><G><I><K><G><E><P><G><F><I><G><P><Q><G><E><P><G><L><P><G><L><P><G><T><K><G><E><R><G><E><A><G><P><P><G><R><G><E><R><G><E><P><G><A><P><G><P><K><G><K><Q><G><E><S><G><T><R><G><P><K><G><S><K><G><D><R><G><E><K><G><D><S><G><A><Q><G><P><R><G><P><P><G><Q><K><G><D><Q><G><A><T><E><I><I><D><Y><N><G><N><L><H><E><A><L><Q><R><I><T><T><L><T><V><T><G><P><P><G><P><P><G><P><Q><G><L><Q><G><P><K><G><E><Q><G><S><P><G><I><P><G><M><D><G><E><Q><G><L><K><G><S><K><G><D><M><G><D><P><G><M><T><G><E><K><G><G><I><G><L><P><G><L><P><G><A><N><G><M><K><G><E><K><G><D><S><G><M><P><G><P><Q><G><P><S><I><I><G><P><P><G><P><P><G><P><H><G><P><P><G><P><M><G><P><H><G><L><P><G><P><K><G><T><D><G><P><M><G><P><H><G><P><A><G><P><K><G><E><R><G><E><K><G><A><M><G><E><P><G><P><R><G><P><Y><G><L><P><G><K><D><G><E><P><G><L><D><G><F><P><G><P><R><G><E><K><G><D><L><G><E><K><G><E><K><G><F><R><G><V><K><G><E><K><G><E><P><G><Q><P><G><L><D><G><L><D><A><P><C><Q><L><G><P><D><G><L><P><M><P><G><C><W><Q><K> | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.<BOP> | Q9BXS0 |
A0A0K0K1B3 | TVB30_HUMAN | T cell receptor beta variable 30 | Homo | <M><L><C><S><L><L><A><L><L><L><G><T><F><F><G><V><R><S><Q><T><I><H><Q><W><P><A><T><L><V><Q><P><V><G><S><P><L><S><L><E><C><T><V><E><G><T><S><N><P><N><L><Y><W><Y><R><Q><A><A><G><R><G><L><Q><L><L><F><Y><S><V><G><I><G><Q><I><S><S><E><V><P><Q><N><L><S><A><S><R><P><Q><D><R><Q><F><I><L><S><S><K><K><L><L><L><S><D><S><G><F><Y><L><C><A><W><S> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0K0K1B3 |
P01766 | HV313_HUMAN | Ig heavy chain V-III region BRO | Homo | <M><E><L><G><L><S><W><V><F><L><V><A><I><L><E><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><Q><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><D><M><H><W><V><R><Q><A><T><G><K><G><L><E><W><V><S><A><I><G><T><A><G><D><P><Y><Y><P><G><S><V><K><G><R><F><T><I><S><R><E><N><A><K><N><S><L><Y><L><Q><M><N><S><L><R><A><G><D><T><A><V><Y><Y><C><A><R> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P01766 |
Q15172 | 2A5A_HUMAN | PP2A B subunit isoform R5-alpha | Homo | <M><S><S><S><S><P><P><A><G><A><A><S><A><A><I><S><A><S><E><K><V><D><G><F><T><R><K><S><V><R><K><A><Q><R><Q><K><R><S><Q><G><S><S><Q><F><R><S><Q><G><S><Q><A><E><L><H><P><L><P><Q><L><K><D><A><T><S><N><E><Q><Q><E><L><F><C><Q><K><L><Q><Q><C><C><I><L><F><D><F><M><D><S><V><S><D><L><K><S><K><E><I><K><R><A><T><L><N><E><L><V><E><Y><V><S><T><N><R><G><V><I><V><E><S><A><Y><S><D><I><V><K><M><I><S><A><N><I><F><R><T><L><P><P><S><D><N><P><D><F><D><P><E><E><D><E><P><T><L><E><A><S><W><P><H><I><Q><L><V><Y><E><F><F><L><R><F><L><E><S><P><D><F><Q><P><S><I><A><K><R><Y><I><D><Q><K><F><V><Q><Q><L><L><E><L><F><D><S><E><D><P><R><E><R><D><F><L><K><T><V><L><H><R><I><Y><G><K><F><L><G><L><R><A><F><I><R><K><Q><I><N><N><I><F><L><R><F><I><Y><E><T><E><H><F><N><G><V><A><E><L><L><E><I><L><G><S><I><I><N><G><F><A><L><P><L><K><A><E><H><K><Q><F><L><M><K><V><L><I><P><M><H><T><A><K><G><L><A><L><F><H><A><Q><L><A><Y><C><V><V><Q><F><L><E><K><D><T><T><L><T><E><P><V><I><R><G><L><L><K><F><W><P><K><T><C><S><Q><K><E><V><M><F><L><G><E><I><E><E><I><L><D><V><I><E><P><T><Q><F><K><K><I><E><E><P><L><F><K><Q><I><S><K><C><V><S><S><S><H><F><Q><V><A><E><R><A><L><Y><F><W><N><N><E><Y><I><L><S><L><I><E><E><N><I><D><K><I><L><P><I><M><F><A><S><L><Y><K><I><S><K><E><H><W><N><P><T><I><V><A><L><V><Y><N><V><L><K><T><L><M><E><M><N><G><K><L><F><D><D><L><T><S><S><Y><K><A><E><R><Q><R><E><K><K><K><E><L><E><R><E><E><L><W><K><K><L><E><E><L><K><L><K><K><A><L><E><K><Q><N><S><A><Y><N><M><H><S><I><L><S><N><T><S><A><E> | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.<BOP> | Q15172 |
P02808 | STAT_HUMAN | Statherin | Homo | <M><K><F><L><V><F><A><F><I><L><A><L><M><V><S><M><I><G><A><D><S><S><E><E><K><F><L><R><R><I><G><R><F><G><Y><G><Y><G><P><Y><Q><P><V><P><E><Q><P><L><Y><P><Q><P><Y><Q><P><Q><Y><Q><Q><Y><T><F> | Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.<BOP> | P02808 |
P27144 | KAD4_HUMAN | GTP:AMP phosphotransferase AK4 | Homo | <M><A><S><K><L><L><R><A><V><I><L><G><P><P><G><S><G><K><G><T><V><C><Q><R><I><A><Q><N><F><G><L><Q><H><L><S><S><G><H><F><L><R><E><N><I><K><A><S><T><E><V><G><E><M><A><K><Q><Y><I><E><K><S><L><L><V><P><D><H><V><I><T><R><L><M><M><S><E><L><E><N><R><R><G><Q><H><W><L><L><D><G><F><P><R><T><L><G><Q><A><E><A><L><D><K><I><C><E><V><D><L><V><I><S><L><N><I><P><F><E><T><L><K><D><R><L><S><R><R><W><I><H><P><P><S><G><R><V><Y><N><L><D><F><N><P><P><H><V><H><G><I><D><D><V><T><G><E><P><L><V><Q><Q><E><D><D><K><P><E><A><V><A><A><R><L><R><Q><Y><K><D><V><A><K><P><V><I><E><L><Y><K><S><R><G><V><L><H><Q><F><S><G><T><E><T><N><K><I><W><P><Y><V><Y><T><L><F><S><N><K><I><T><P><I><Q><S><K><E><A><Y> | Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates . Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor . Also displays broad nucleoside diphosphate kinase activity . Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK . Plays a protective role in the cellular response to oxidative stress .<BOP> | P27144 |
Q96CD0 | FBXL8_HUMAN | F-box protein FBL8 | Homo | <M><A><E><P><G><E><G><L><P><E><E><V><L><A><L><I><F><R><H><L><S><L><R><D><R><A><A><A><A><R><V><C><R><A><W><A><A><A><A><T><C><S><A><V><W><H><D><T><K><I><S><C><E><C><E><L><E><G><M><L><P><P><Y><L><S><A><C><L><D><H><I><H><N><L><R><L><E><F><E><P><S><R><K><P><S><R><R><A><A><I><E><L><L><M><V><L><A><G><R><A><P><G><L><R><G><L><R><L><E><C><R><G><E><K><P><L><F><D><A><G><R><D><V><L><E><A><V><H><A><V><C><G><A><A><S><Q><L><R><H><L><D><L><R><R><L><S><F><T><L><D><D><A><L><V><L><Q><A><A><R><S><C><P><E><L><H><S><L><F><L><D><N><S><T><L><V><G><S><V><G><P><G><S><V><L><E><L><L><E><A><C><P><R><L><R><A><L><G><L><H><L><A><S><L><S><H><A><I><L><E><A><L><A><A><P><D><R><A><P><F><A><L><L><A><L><R><C><A><C><P><E><D><A><R><A><S><P><L><P><N><E><A><W><V><A><L><R><R><R><H><P><G><L><A><V><E><L><E><L><E><P><A><L><P><A><E><S><V><T><R><V><L><Q><P><A><V><P><V><A><A><L><R><L><N><L><S><G><D><T><V><G><P><V><R><F><A><A><H><H><Y><A><A><T><L><C><A><L><E><V><R><A><A><A><S><A><E><L><N><A><A><L><E><E><L><A><A><R><C><A><A><L><R><E><V><H><C><F><C><V><V><S><H><S><V><L><D><A><F><R><A><H><C><P><R><L><R><T><Y><T><L><K><L><T><R><E><P><H><P><W><R><P><T><L><V><A> | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP> | Q96CD0 |
Q96KK4 | O10C1_HUMAN | Olfactory receptor 10C2 | Homo | <M><S><A><N><T><S><M><V><T><E><F><L><L><L><G><F><S><H><L><A><D><L><Q><G><L><L><F><S><V><F><L><T><I><Y><L><L><T><V><A><G><N><F><L><I><V><V><L><V><S><T><D><A><A><L><Q><S><P><M><Y><F><F><L><R><T><L><S><A><L><E><I><G><Y><T><S><V><T><V><P><L><L><L><H><H><L><L><T><G><R><R><H><I><S><R><S><G><C><A><L><Q><M><F><F><F><L><F><F><G><A><T><E><C><C><L><L><A><A><M><A><Y><D><R><Y><A><A><I><C><E><P><L><R><Y><P><L><L><L><S><H><R><V><C><L><Q><L><A><G><S><A><W><A><C><G><V><L><V><G><L><G><H><T><P><F><I><F><S><L><P><F><C><G><P><N><T><I><P><Q><F><F><C><E><I><Q><P><V><L><Q><L><V><C><G><D><T><S><L><N><E><L><Q><I><I><L><A><T><A><L><L><I><L><C><P><F><G><L><I><L><G><S><Y><G><R><I><L><V><T><I><F><R><I><P><S><V><A><G><R><R><K><A><F><S><T><C><S><S><H><L><I><M><V><S><L><F><Y><G><T><A><L><F><I><Y><I><R><P><K><A><S><Y><D><P><A><T><D><P><L><V><S><L><F><Y><A><V><V><T><P><I><L><N><P><I><I><Y><S><L><R><N><T><E><V><K><A><A><L><K><R><T><I><Q><K><T><V><P><M><E><I> | Odorant receptor.<BOP> | Q96KK4 |
Q7Z340 | ZN551_HUMAN | Zinc finger protein KOX23 | Homo | <M><P><A><P><V><G><R><R><S><P><P><S><P><R><S><S><M><A><A><V><A><L><R><D><S><A><Q><G><M><T><F><E><D><V><A><I><Y><F><S><Q><E><E><W><E><L><L><D><E><S><Q><R><F><L><Y><C><D><V><M><L><E><N><F><A><H><V><T><S><L><G><Y><C><H><G><M><E><N><E><A><I><A><S><E><Q><S><V><S><I><Q><V><R><T><S><K><G><N><T><P><T><Q><K><T><H><L><S><E><I><K><M><C><V><P><V><L><K><D><I><L><P><A><A><E><H><Q><T><T><S><P><V><Q><K><S><Y><L><G><S><T><S><M><R><G><F><C><F><S><A><D><L><H><Q><H><Q><K><H><Y><N><E><E><E><P><W><K><R><K><V><D><E><A><T><F><V><T><G><C><R><F><H><V><L><N><Y><F><T><C><G><E><A><F><P><A><P><T><D><L><L><Q><H><E><A><T><P><S><G><E><E><P><H><S><S><S><S><K><H><I><Q><A><F><F><N><A><K><S><Y><Y><K><W><G><E><Y><R><K><A><S><S><H><K><H><T><L><V><Q><H><Q><S><V><C><S><E><G><G><L><Y><E><C><S><K><C><E><K><A><F><T><C><K><N><T><L><V><Q><H><Q><Q><I><H><T><G><Q><K><M><F><E><C><S><E><C><E><E><S><F><S><K><K><C><H><L><I><L><H><K><I><I><H><T><G><E><R><P><Y><E><C><S><D><R><E><K><A><F><I><H><K><S><E><F><I><H><H><Q><R><R><H><T><G><G><V><R><H><E><C><G><E><C><R><K><T><F><S><Y><K><S><N><L><I><E><H><Q><R><V><H><T><G><E><R><P><Y><E><C><G><E><C><G><K><S><F><R><Q><S><S><S><L><F><R><H><Q><R><V><H><S><G><E><R><P><Y><Q><C><C><E><C><G><K><S><F><R><Q><I><F><N><L><I><R><H><R><R><V><H><T><G><E><M><P><Y><Q><C><S><D><C><G><K><S><F><S><C><K><S><E><L><I><Q><H><Q><R><I><H><S><G><E><R><P><Y><E><C><R><E><C><G><K><S><F><R><Q><F><S><N><L><I><R><H><R><S><I><H><T><G><D><R><P><Y><E><C><S><E><C><E><K><S><F><S><R><K><F><I><L><I><Q><H><Q><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><T><R><K><S><D><L><I><Q><H><R><R><I><H><T><G><T><R><P><Y><E><C><S><E><C><G><K><S><F><R><Q><R><S><G><L><I><Q><H><R><R><L><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><Q><S><A><S><L><I><Q><H><Q><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><Q><S><S><S><L><I><Q><H><Q><R><G><H><T><G><E><R><P><Y><E><C><S><Q><C><G><K><P><F><T><H><K><S><D><L><I><Q><H><Q><R><V><H><T><G><E><R><P><Y><E><C><S><E><C><G><K><S><F><S><R><K><S><N><L><I><R><H><R><R><V><H><T><E><E><R><P> | May be involved in transcriptional regulation.<BOP> | Q7Z340 |
Q8IYS4 | DAAF8_HUMAN | Dynein axonemal-associated protein 1 | Homo | <M><A><S><N><D><K><G><M><A><P><S><L><G><S><P><W><A><S><Q><M><G><P><W><D><A><I><L><K><A><V><K><D><Q><L><P><S><L><D><S><D><S><P><L><S><D><Y><G><E><E><E><L><F><I><F><Q><R><N><Q><T><S><L><I><P><D><L><S><E><E><L><A><E><D><P><A><D><G><D><K><S><R><A><W><V><A><A><A><E><E><S><L><P><E><P><V><L><V><P><A><E><L><A><T><E><P><G><C><R><Q><N><T><R><T><K><D><A><S><S><Q><E><G><R><D><P><G><R><P><F><E><S><S><G><E><V><S><A><L><L><G><M><A><E><E><P><P><R><W><L><E><G><D><L><G><S><L><S><F><N><T><K><G><S><Q><G><P><P><W><D><P><Q><A><E><A><T><L><S><C><H><E><G><D><P><K><A><E><P><L><S><T><A><S><Q><E><S><V><N><R><R><A><L><R><Q><E><R><R><K><M><I><E><T><D><I><L><Q><K><V><T><R><D><A><C><G><P><T><S><S><D><K><G><G><V><K><E><A><P><C><H><A><A><E><S><A><P><R><S><K><M><P><L><V><E><P><P><E><G><P><P><V><L><S><L><Q><Q><L><E><A><W><D><L><D><D><I><L><Q><S><L><A><G><Q><E><D><N><Q><G><N><R><A><P><G><T><V><W><W><A><A><D><H><R><Q><V><Q><D><R><M><V><P><S><A><H><N><R><L><M><E><Q><L><A><L><L><C><T><T><Q><S><K><A><S><A><C><A><R><K><V><P><A><D><T><P><Q><D><T><K><E><A><D><S><G><S><R><C><A><S><R><K><Q><G><S><Q><A><G><P><G><P><Q><L><A><Q><G><M><R><L><N><A><E><S><P><T><I><F><I><D><L><R><Q><M><E><L><P><D><H><L><S><P><E><S><S><S><H><S><S><S><D><S><E><E><E><E><E><E><E><M><A><A><L><G><D><A><E><G><A><S><P><S><S><L><G><L><R><T><C><T><G><K><S><Q><L><L><Q><Q><L><R><A><F><Q><K><G><T><A><Q><P><E><L><P><A><S><K><G><P><A><G><G><R><A><Q><A><P><E><D><T><A><G><S><R><T><G><R><K><Q><H><M><K><L><C><A><K><G><Q><S><A><Q><A><R><L><P><R><G><R><P><R><A><L><G><D><V><P><E><P><G><A><A><R><E><A><L><M><P><P><L><E><Q><L> | In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.<BOP> | Q8IYS4 |
O95125 | ZN202_HUMAN | Zinc finger protein with KRAB and SCAN domains 10 | Homo | <M><A><T><A><V><E><P><E><D><Q><D><L><W><E><E><E><G><I><L><M><V><K><L><E><D><D><F><T><C><R><P><E><S><V><L><Q><R><D><D><P><V><L><E><T><S><H><Q><N><F><R><R><F><R><Y><Q><E><A><A><S><P><R><E><A><L><I><R><L><R><E><L><C><H><Q><W><L><R><P><E><R><R><T><K><E><Q><I><L><E><L><L><V><L><E><Q><F><L><T><V><L><P><G><E><L><Q><S><W><V><R><G><Q><R><P><E><S><G><E><E><A><V><T><L><V><E><G><L><Q><K><Q><P><R><R><P><R><R><W><V><T><V><H><V><H><G><Q><E><V><L><S><E><E><T><V><H><L><G><V><E><P><E><S><P><N><E><L><Q><D><P><V><Q><S><S><T><P><E><Q><S><P><E><E><T><T><Q><S><P><D><L><G><A><P><A><E><Q><R><P><H><Q><E><E><E><L><Q><T><L><Q><E><S><E><V><P><V><P><E><D><P><D><L><P><A><E><R><S><S><G><D><S><E><M><V><A><L><L><T><A><L><S><Q><G><L><V><T><F><K><D><V><A><V><C><F><S><Q><D><Q><W><S><D><L><D><P><T><Q><K><E><F><Y><G><E><Y><V><L><E><E><D><C><G><I><V><V><S><L><S><F><P><I><P><R><P><D><E><I><S><Q><V><R><E><E><E><P><W><V><P><D><I><Q><E><P><Q><E><T><Q><E><P><E><I><L><S><F><T><Y><T><G><D><R><S><K><D><E><E><E><C><L><E><Q><E><D><L><S><L><E><D><I><H><R><P><V><L><G><E><P><E><I><H><Q><T><P><D><W><E><I><V><F><E><D><N><P><G><R><L><N><E><R><R><F><G><T><N><I><S><Q><V><N><S><F><V><N><L><R><E><T><T><P><V><H><P><L><L><G><R><H><H><D><C><S><V><C><G><K><S><F><T><C><N><S><H><L><V><R><H><L><R><T><H><T><G><E><K><P><Y><K><C><M><E><C><G><K><S><Y><T><R><S><S><H><L><A><R><H><Q><K><V><H><K><M><N><A><P><Y><K><Y><P><L><N><R><K><N><L><E><E><T><S><P><V><T><Q><A><E><R><T><P><S><V><E><K><P><Y><R><C><D><D><C><G><K><H><F><R><W><T><S><D><L><V><R><H><Q><R><T><H><T><G><E><K><P><F><F><C><T><I><C><G><K><S><F><S><Q><K><S><V><L><T><T><H><Q><R><I><H><L><G><G><K><P><Y><L><C><G><E><C><G><E><D><F><S><E><H><R><R><Y><L><A><H><R><K><T><H><A><A><E><E><L><Y><L><C><S><E><C><G><R><C><F><T><H><S><A><A><F><A><K><H><L><R><G><H><A><S><V><R><P><C><R><C><N><E><C><G><K><S><F><S><R><R><D><H><L><V><R><H><Q><R><T><H><T><G><E><K><P><F><T><C><P><T><C><G><K><S><F><S><R><G><Y><H><L><I><R><H><Q><R><T><H><S><E><K><T><S> | Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.<BOP> | O95125 |
A0A1B0GX51 | TVB78_HUMAN | T cell receptor beta variable 7-8 | Homo | <M><G><T><R><L><L><C><W><V><V><L><G><F><L><G><T><D><H><T><G><A><G><V><S><Q><S><P><R><Y><K><V><A><K><R><G><Q><D><V><A><L><R><C><D><P><I><S><G><H><V><S><L><F><W><Y><Q><Q><A><L><G><Q><G><P><E><F><L><T><Y><F><Q><N><E><A><Q><L><D><K><S><G><L><P><S><D><R><F><F><A><E><R><P><E><G><S><V><S><T><L><K><I><Q><R><T><Q><Q><E><D><S><A><V><Y><L><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A1B0GX51 |
Q9H5X1 | CIA2A_HUMAN | MIP18 family protein FAM96A | Homo | <M><Q><R><V><S><G><L><L><S><W><T><L><S><R><V><L><W><L><S><G><L><S><E><P><G><A><A><R><Q><P><R><I><M><E><E><K><A><L><E><V><Y><D><L><I><R><T><I><R><D><P><E><K><P><N><T><L><E><E><L><E><V><V><S><E><S><C><V><E><V><Q><E><I><N><E><E><E><Y><L><V><I><I><R><F><T><P><T><V><P><H><C><S><L><A><T><L><I><G><L><C><L><R><V><K><L><Q><R><C><L><P><F><K><H><K><L><E><I><Y><I><S><E><G><T><H><S><T><E><E><D><I><N><K><Q><I><N><D><K><E><R><V><A><A><A><M><E><N><P><N><L><R><E><I><V><E><Q><C><V><L><E><P><D> | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation . May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 .<BOP> | Q9H5X1 |
Q9UPT9 | UBP22_HUMAN | Ubiquitin-specific-processing protease 22 | Homo | <M><V><S><R><P><E><P><E><G><E><A><M><D><A><E><L><A><V><A><P><P><G><C><S><H><L><G><S><F><K><V><D><N><W><K><Q><N><L><R><A><I><Y><Q><C><F><V><W><S><G><T><A><E><A><R><K><R><K><A><K><S><C><I><C><H><V><C><G><V><H><L><N><R><L><H><S><C><L><Y><C><V><F><F><G><C><F><T><K><K><H><I><H><E><H><A><K><A><K><R><H><N><L><A><I><D><L><M><Y><G><G><I><Y><C><F><L><C><Q><D><Y><I><Y><D><K><D><M><E><I><I><A><K><E><E><Q><R><K><A><W><K><M><Q><G><V><G><E><K><F><S><T><W><E><P><T><K><R><E><L><E><L><L><K><H><N><P><K><R><R><K><I><T><S><N><C><T><I><G><L><R><G><L><I><N><L><G><N><T><C><F><M><N><C><I><V><Q><A><L><T><H><T><P><L><L><R><D><F><F><L><S><D><R><H><R><C><E><M><Q><S><P><S><S><C><L><V><C><E><M><S><S><L><F><Q><E><F><Y><S><G><H><R><S><P><H><I><P><Y><K><L><L><H><L><V><W><T><H><A><R><H><L><A><G><Y><E><Q><Q><D><A><H><E><F><L><I><A><A><L><D><V><L><H><R><H><C><K><G><D><D><N><G><K><K><A><N><N><P><N><H><C><N><C><I><I><D><Q><I><F><T><G><G><L><Q><S><D><V><T><C><Q><V><C><H><G><V><S><T><T><I><D><P><F><W><D><I><S><L><D><L><P><G><S><S><T><P><F><W><P><L><S><P><G><S><E><G><N><V><V><N><G><E><S><H><V><S><G><T><T><T><L><T><D><C><L><R><R><F><T><R><P><E><H><L><G><S><S><A><K><I><K><C><S><G><C><H><S><Y><Q><E><S><T><K><Q><L><T><M><K><K><L><P><I><V><A><C><F><H><L><K><R><F><E><H><S><A><K><L><R><R><K><I><T><T><Y><V><S><F><P><L><E><L><D><M><T><P><F><M><A><S><S><K><E><S><R><M><N><G><Q><Y><Q><Q><P><T><D><S><L><N><N><D><N><K><Y><S><L><F><A><V><V><N><H><Q><G><T><L><E><S><G><H><Y><T><S><F><I><R><Q><H><K><D><Q><W><F><K><C><D><D><A><I><I><T><K><A><S><I><K><D><V><L><D><S><E><G><Y><L><L><F><Y><H><K><Q><F><L><E><Y><E> | Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.<BOP> | Q9UPT9 |
P28562 | DUS1_HUMAN | Protein-tyrosine phosphatase CL100 | Homo | <M><V><M><E><V><G><T><L><D><A><G><G><L><R><A><L><L><G><E><R><A><A><Q><C><L><L><L><D><C><R><S><F><F><A><F><N><A><G><H><I><A><G><S><V><N><V><R><F><S><T><I><V><R><R><R><A><K><G><A><M><G><L><E><H><I><V><P><N><A><E><L><R><G><R><L><L><A><G><A><Y><H><A><V><V><L><L><D><E><R><S><A><A><L><D><G><A><K><R><D><G><T><L><A><L><A><A><G><A><L><C><R><E><A><R><A><A><Q><V><F><F><L><K><G><G><Y><E><A><F><S><A><S><C><P><E><L><C><S><K><Q><S><T><P><M><G><L><S><L><P><L><S><T><S><V><P><D><S><A><E><S><G><C><S><S><C><S><T><P><L><Y><D><Q><G><G><P><V><E><I><L><P><F><L><Y><L><G><S><A><Y><H><A><S><R><K><D><M><L><D><A><L><G><I><T><A><L><I><N><V><S><A><N><C><P><N><H><F><E><G><H><Y><Q><Y><K><S><I><P><V><E><D><N><H><K><A><D><I><S><S><W><F><N><E><A><I><D><F><I><D><S><I><K><N><A><G><G><R><V><F><V><H><C><Q><A><G><I><S><R><S><A><T><I><C><L><A><Y><L><M><R><T><N><R><V><K><L><D><E><A><F><E><F><V><K><Q><R><R><S><I><I><S><P><N><F><S><F><M><G><Q><L><L><Q><F><E><S><Q><V><L><A><P><H><C><S><A><E><A><G><S><P><A><M><A><V><L><D><R><G><T><S><T><T><T><V><F><N><F><P><V><S><I><P><V><H><S><T><N><S><A><L><S><Y><L><Q><S><P><I><T><T><S><P><S><C> | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.<BOP> | P28562 |
O15091 | MRPP3_HUMAN | Protein only RNase P catalytic subunit | Homo | <M><T><F><Y><L><F><G><I><R><S><F><P><K><L><W><K><S><P><Y><L><G><L><G><P><G><H><S><Y><V><S><L><F><L><A><D><R><C><G><I><R><N><Q><Q><R><L><F><S><L><K><T><M><S><P><Q><N><T><K><A><T><N><L><I><A><K><A><R><Y><L><R><K><D><E><G><S><N><K><Q><V><Y><S><V><P><H><F><F><L><A><G><A><A><K><E><R><S><Q><M><N><S><Q><T><E><D><H><A><L><A><P><V><R><N><T><I><Q><L><P><T><Q><P><L><N><S><E><E><W><D><K><L><K><E><D><L><K><E><N><T><G><K><T><S><F><E><S><W><I><I><S><Q><M><A><G><C><H><S><S><I><D><V><A><K><S><L><L><A><W><V><A><A><K><N><N><G><I><V><S><Y><D><L><L><V><K><Y><L><Y><L><C><V><F><H><M><Q><T><S><E><V><I><D><V><F><E><I><M><K><A><R><Y><K><T><L><E><P><R><G><Y><S><L><L><I><R><G><L><I><H><S><D><R><W><R><E><A><L><L><L><L><E><D><I><K><K><V><I><T><P><S><K><K><N><Y><N><D><C><I><Q><G><A><L><L><H><Q><D><V><N><T><A><W><N><L><Y><Q><E><L><L><G><H><D><I><V><P><M><L><E><T><L><K><A><F><F><D><F><G><K><D><I><K><D><D><N><Y><S><N><K><L><L><D><I><L><S><Y><L><R><N><N><Q><L><Y><P><G><E><S><F><A><H><S><I><K><T><W><F><E><S><V><P><G><K><Q><W><K><G><Q><F><T><T><V><R><K><S><G><Q><C><S><G><C><G><K><T><I><E><S><I><Q><L><S><P><E><E><Y><E><C><L><K><G><K><I><M><R><D><V><I><D><G><G><D><Q><Y><R><K><T><T><P><Q><E><L><K><R><F><E><N><F><I><K><S><R><P><P><F><D><V><V><I><D><G><L><N><V><A><K><M><F><P><K><V><R><E><S><Q><L><L><L><N><V><V><S><Q><L><A><K><R><N><L><R><L><L><V><L><G><R><K><H><M><L><R><R><S><S><Q><W><S><R><D><E><M><E><E><V><Q><K><Q><A><S><C><F><F><A><D><D><I><S><E><D><D><P><F><L><L><Y><A><T><L><H><S><G><N><H><C><R><F><I><T><R><D><L><M><R><D><H><K><A><C><L><P><D><A><K><T><Q><R><L><F><F><K><W><Q><Q><G><H><Q><L><A><I><V><N><R><F><P><G><S><K><L><T><F><Q><R><I><L><S><Y><D><T><V><V><Q><T><T><G><D><S><W><H><I><P><Y><D><E><D><L><V><E><R><C><S><C><E><V><P><T><K><W><L><C><L><H><Q><K><T> | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends . The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends .<BOP> | O15091 |
P54792 | DVLP1_HUMAN | Segment polarity protein dishevelled homolog DVL-1-like | Homo | <M><A><E><T><K><I><I><Y><H><M><D><E><E><E><T><P><Y><L><V><K><L><P><V><A><P><E><R><V><T><L><A><D><F><K><N><V><L><S><N><R><P><V><H><A><Y><K><F><F><F><K><S><M><D><Q><D><F><G><V><V><K><E><E><I><F><D><D><N><A><K><L><P><C><F><N><G><R><V><V><S><W><L><V><L><V><E><G><A><H><S><D><A><G><S><Q><G><T><D><S><H><T><D><L><P><P><P><L><E><R><T><G><G><I><G><D><S><R><S><P><S><F><Q><P><D><V><A><S><S><R><D><G><M><D><N><E><T><G><T><E><S><M><V><S><H><R><R><D><R><A><R><R><R><N><R><E><E><A><A><R><T><N><G><H><P><R><G><D><R><R><R><D><V><G><L><P><P><D><S><A><S><T><A><L><S><S><E><L><E><S><S><S><F><V><D><S><D><E><D><D><S><T><S><R><L><S><S><S><T><E><Q><S><T><S><S><R><L><I><R><K><H><K><R><R><R><R><K><Q><R><L><R><Q><A><D><R><A><S><S><F><S><S><M><T><D><S><T><M><S><L><N><I><I><T><V><T><L><N><M><E><R><H><H><F><L><G><I><C><I><V><G><Q><S><N><D><R><G><D><G><G><I><Y><I><G><S><I><M><K><G><G><A><V><A><A><D><G><R><I><E><P><G><D><M><L><L><Q><V><N><D><V><N><F><E><N><M><S><N><D><D><A><V><R><V><L><R><E><I><V><S><Q><T><G><P><I><S><L><T><V><A><K><C><W><D><P><T><P><R><S><Y><F><T><V><P><R><P><D><P><V><R><P><I><D><P><A><A><W><L><S><H><T><A><A><L><T><G><A><L><P><R><P><Q><L><E><E><A><P><L><T><V><E><S><D><M><N><T><V><V><R><V><M><Q><L><P><D><S><G><L><E><I><R><D><R><M><W><L><K><I><T><I><A><N><A><V><I><G><A><D><V><V><D><W><L><Y><T><H><V><E><G><F><K><E><R><R><E><A><R><K><Y><A><S><S><L><L><K><H><G><F><L><R><H><T><V><N><K><I><T><F><S><E><Q><C><Y><Y><V><F><G><D><L><C><S><N><L><A><T><L><N><L><N><S><G><S><S><G><T><S><D><Q><D><T><L><A><P><L><P><H><P><A><A><P><W><P><L><G><Q><G><Y><P><Y><Q><Y><P><G><P><P><P><C><F><P><P><A><Y><Q><D><P><G><F><S><Y><G><S><G><S><T><G><S><Q><Q><S><E><G><S><K><S><S><G><S><T><R><N><T><L><R><P><P><A><C><E><K><E><R><R><A><A><G><S><G><D><S><D><S><E><S><D><H><T><A><P><S><G><V><G><S><S><W><R><E><R><P><A><D><Q><L><S><R><G><S><S><P><R><S><Q><A><S><S><Y><A><P><G><L><P><P><P><H><P><T><T><K><A><Y><T><V><V><G><G><P><P><G><G><P><P><V><R><E><L><A><A><V><P><P><E><L><T><G><S><R><Q><S><F><Q><K><A><M><G><N><P><C><E><F><F><V><D><I><M> | May play a role in the signal transduction pathway mediated by multiple Wnt genes.<BOP> | P54792 |
P42898 | MTHR_HUMAN | Methylenetetrahydrofolate reductase | Homo | <M><V><N><E><A><R><G><N><S><S><L><N><P><C><L><E><G><S><A><S><S><G><S><E><S><S><K><D><S><S><R><C><S><T><P><G><L><D><P><E><R><H><E><R><L><R><E><K><M><R><R><R><L><E><S><G><D><K><W><F><S><L><E><F><F><P><P><R><T><A><E><G><A><V><N><L><I><S><R><F><D><R><M><A><A><G><G><P><L><Y><I><D><V><T><W><H><P><A><G><D><P><G><S><D><K><E><T><S><S><M><M><I><A><S><T><A><V><N><Y><C><G><L><E><T><I><L><H><M><T><C><C><R><Q><R><L><E><E><I><T><G><H><L><H><K><A><K><Q><L><G><L><K><N><I><M><A><L><R><G><D><P><I><G><D><Q><W><E><E><E><E><G><G><F><N><Y><A><V><D><L><V><K><H><I><R><S><E><F><G><D><Y><F><D><I><C><V><A><G><Y><P><K><G><H><P><E><A><G><S><F><E><A><D><L><K><H><L><K><E><K><V><S><A><G><A><D><F><I><I><T><Q><L><F><F><E><A><D><T><F><F><R><F><V><K><A><C><T><D><M><G><I><T><C><P><I><V><P><G><I><F><P><I><Q><G><Y><H><S><L><R><Q><L><V><K><L><S><K><L><E><V><P><Q><E><I><K><D><V><I><E><P><I><K><D><N><D><A><A><I><R><N><Y><G><I><E><L><A><V><S><L><C><Q><E><L><L><A><S><G><L><V><P><G><L><H><F><Y><T><L><N><R><E><M><A><T><T><E><V><L><K><R><L><G><M><W><T><E><D><P><R><R><P><L><P><W><A><L><S><A><H><P><K><R><R><E><E><D><V><R><P><I><F><W><A><S><R><P><K><S><Y><I><Y><R><T><Q><E><W><D><E><F><P><N><G><R><W><G><N><S><S><S><P><A><F><G><E><L><K><D><Y><Y><L><F><Y><L><K><S><K><S><P><K><E><E><L><L><K><M><W><G><E><E><L><T><S><E><E><S><V><F><E><V><F><V><L><Y><L><S><G><E><P><N><R><N><G><H><K><V><T><C><L><P><W><N><D><E><P><L><A><A><E><T><S><L><L><K><E><E><L><L><R><V><N><R><Q><G><I><L><T><I><N><S><Q><P><N><I><N><G><K><P><S><S><D><P><I><V><G><W><G><P><S><G><G><Y><V><F><Q><K><A><Y><L><E><F><F><T><S><R><E><T><A><E><A><L><L><Q><V><L><K><K><Y><E><L><R><V><N><Y><H><L><V><N><V><K><G><E><N><I><T><N><A><P><E><L><Q><P><N><A><V><T><W><G><I><F><P><G><R><E><I><I><Q><P><T><V><V><D><P><V><S><F><M><F><W><K><D><E><A><F><A><L><W><I><E><R><W><G><K><L><Y><E><E><E><S><P><S><R><T><I><I><Q><Y><I><H><D><N><Y><F><L><V><N><L><V><D><N><D><F><P><L><D><N><C><L><W><Q><V><V><E><D><T><L><E><L><L><N><R><P><T><Q><N><A><R><E><T><E><A><P> | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine . Represents a key regulatory connection between the folate and methionine cycles (Probable).<BOP> | P42898 |
P43357 | MAGA3_HUMAN | MAGE-3 antigen | Homo | <M><P><L><E><Q><R><S><Q><H><C><K><P><E><E><G><L><E><A><R><G><E><A><L><G><L><V><G><A><Q><A><P><A><T><E><E><Q><E><A><A><S><S><S><S><T><L><V><E><V><T><L><G><E><V><P><A><A><E><S><P><D><P><P><Q><S><P><Q><G><A><S><S><L><P><T><T><M><N><Y><P><L><W><S><Q><S><Y><E><D><S><S><N><Q><E><E><E><G><P><S><T><F><P><D><L><E><S><E><F><Q><A><A><L><S><R><K><V><A><E><L><V><H><F><L><L><L><K><Y><R><A><R><E><P><V><T><K><A><E><M><L><G><S><V><V><G><N><W><Q><Y><F><F><P><V><I><F><S><K><A><S><S><S><L><Q><L><V><F><G><I><E><L><M><E><V><D><P><I><G><H><L><Y><I><F><A><T><C><L><G><L><S><Y><D><G><L><L><G><D><N><Q><I><M><P><K><A><G><L><L><I><I><V><L><A><I><I><A><R><E><G><D><C><A><P><E><E><K><I><W><E><E><L><S><V><L><E><V><F><E><G><R><E><D><S><I><L><G><D><P><K><K><L><L><T><Q><H><F><V><Q><E><N><Y><L><E><Y><R><Q><V><P><G><S><D><P><A><C><Y><E><F><L><W><G><P><R><A><L><V><E><T><S><Y><V><K><V><L><H><H><M><V><K><I><S><G><G><P><H><I><S><Y><P><P><L><H><E><W><V><L><R><E><G><E><E> | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy . May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex . May play a role in embryonal development and tumor transformation or aspects of tumor progression . In vitro promotes cell viability in melanoma cell lines . Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes .<BOP> | P43357 |
Q9BXJ7 | AMNLS_HUMAN | Soluble protein amnionless | Homo | <M><G><V><L><G><R><V><L><L><W><L><Q><L><C><A><L><T><Q><A><V><S><K><L><W><V><P><N><T><D><F><D><V><A><A><N><W><S><Q><N><R><T><P><C><A><G><G><A><V><E><F><P><A><D><K><M><V><S><V><L><V><Q><E><G><H><A><V><S><D><M><L><L><P><L><D><G><E><L><V><L><A><S><G><A><G><F><G><V><S><D><V><G><S><H><L><D><C><G><A><G><E><P><A><V><F><R><D><S><D><R><F><S><W><H><D><P><H><L><W><R><S><G><D><E><A><P><G><L><F><F><V><D><A><E><R><V><P><C><R><H><D><D><V><F><F><P><P><S><A><S><F><R><V><G><L><G><P><G><A><S><P><V><R><V><R><S><I><S><A><L><G><R><T><F><T><R><D><E><D><L><A><V><F><L><A><S><R><A><G><R><L><R><F><H><G><P><G><A><L><S><V><G><P><E><D><C><A><D><P><S><G><C><V><C><G><N><A><E><A><Q><P><W><I><C><A><A><L><L><Q><P><L><G><G><R><C><P><Q><A><A><C><H><S><A><L><R><P><Q><G><Q><C><C><D><L><C><G><A><V><V><L><L><T><H><G><P><A><F><D><L><E><R><Y><R><A><R><I><L><D><T><F><L><G><L><P><Q><Y><H><G><L><Q><V><A><V><S><K><V><P><R><S><S><R><L><R><E><A><D><T><E><I><Q><V><V><L><V><E><N><G><P><E><T><G><G><A><G><R><L><A><R><A><L><L><A><D><V><A><E><N><G><E><A><L><G><V><L><E><A><T><M><R><E><S><G><A><H><V><W><G><S><S><A><A><G><L><A><G><G><V><A><A><A><V><L><L><A><L><L><V><L><L><V><A><P><P><L><L><R><R><A><G><R><L><R><W><R><R><H><E><A><A><A><P><A><G><A><P><L><G><F><R><N><P><V><F><D><V><T><A><S><E><E><L><P><L><P><R><R><L><S><L><V><P><K><A><A><A><D><S><T><S><H><S><Y><F><V><N><P><L><F><A><G><A><E><A><E><A> | Membrane-bound component of the endocytic receptor formed by AMN and CUBN . Required for normal CUBN glycosylation and trafficking to the cell surface . The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 . Required for normal CUBN-mediated protein transport in the kidney (Probable).<BOP> | Q9BXJ7 |
Q9H8M7 | MINY3_HUMAN | Protein CARP | Homo | <M><S><E><L><T><K><E><L><M><E><L><V><W><G><T><K><S><S><P><G><L><S><D><T><I><F><C><R><W><T><Q><G><F><V><F><S><E><S><E><G><S><A><L><E><Q><F><E><G><G><P><C><A><V><I><A><P><V><Q><A><F><L><L><K><K><L><L><F><S><S><E><K><S><S><W><R><D><C><S><E><E><E><Q><K><E><L><L><C><H><T><L><C><D><I><L><E><S><A><C><C><D><H><S><G><S><Y><C><L><V><S><W><L><R><G><K><T><T><E><E><T><A><S><I><S><G><S><P><A><E><S><S><C><Q><V><E><H><S><S><A><L><A><V><E><E><L><G><F><E><R><F><H><A><L><I><Q><K><R><S><F><R><S><L><P><E><L><K><D><A><V><L><D><Q><Y><S><M><W><G><N><K><F><G><V><L><L><F><L><Y><S><V><L><L><T><K><G><I><E><N><I><K><N><E><I><E><D><A><S><E><P><L><I><D><P><V><Y><G><H><G><S><Q><S><L><I><N><L><L><L><T><G><H><A><V><S><N><V><W><D><G><D><R><E><C><S><G><M><K><L><L><G><I><H><E><Q><A><A><V><G><F><L><T><L><M><E><A><L><R><Y><C><K><V><G><S><Y><L><K><S><P><K><F><P><I><W><I><V><G><S><E><T><H><L><T><V><F><F><A><K><D><M><A><L><V><A><P><E><A><P><S><E><Q><A><R><R><V><F><Q><T><Y><D><P><E><D><N><G><F><I><P><D><S><L><L><E><D><V><M><K><A><L><D><L><V><S><D><P><E><Y><I><N><L><M><K><N><K><L><D><P><E><G><L><G><I><I><L><L><G><P><F><L><Q><E><F><F><P><D><Q><G><S><S><G><P><E><S><F><T><V><Y><H><Y><N><G><L><K><Q><S><N><Y><N><E><K><V><M><Y><V><E><G><T><A><V><V><M><G><F><E><D><P><M><L><Q><T><D><D><T><P><I><K><R><C><L><Q><T><K><W><P><Y><I><E><L><L><W><T><T><D><R><S><P><S><L><N> | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.<BOP> | Q9H8M7 |
Q5VY09 | IER5_HUMAN | Immediate early response gene 5 protein | Homo | <M><E><F><K><L><E><A><H><R><I><V><S><I><S><L><G><K><I><Y><N><S><R><V><Q><R><G><G><I><K><L><H><K><N><L><L><V><S><L><V><L><R><S><A><R><Q><V><Y><L><S><D><P><C><P><G><L><Y><L><A><G><P><A><G><T><P><A><P><P><P><Q><Q><Q><P><G><E><P><A><A><G><P><P><A><G><W><G><E><P><P><P><P><A><A><R><A><S><W><P><E><T><E><P><Q><P><E><R><S><S><V><S><D><A><P><R><V><G><D><E><V><P><V><A><T><V><T><G><V><G><D><V><F><Q><G><G><E><A><D><A><T><E><A><A><W><S><R><V><E><G><P><R><Q><A><A><A><R><E><A><E><G><T><A><G><G><W><G><V><F><P><E><V><S><R><A><A><R><R><P><C><G><C><P><L><G><G><E><D><P><P><G><T><P><A><A><T><P><R><A><A><C><C><C><A><P><Q><P><A><E><D><E><P><P><A><P><P><A><V><C><P><R><K><R><C><A><A><G><V><G><G><G><P><A><G><C><P><A><P><G><S><T><P><L><K><K><P><R><R><N><L><E><Q><P><P><S><G><G><E><D><D><D><A><E><E><M><E><T><G><N><V><A><N><L><I><S><I><F><G><S><S><F><S><G><L><L><R><K><S><P><G><G><G><R><E><E><E><E><G><E><E><S><G><P><E><A><A><E><P><G><Q><I><C><C><D><K><P><V><L><R><D><M><N><P><W><S><T><A><I><V><A><F> | Plays a role as a transcription factor . Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner . Mediates negative transcriptional regulation of CDC25B expression . Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A . Involved in the regulation of cell proliferation and resistance to thermal stress . Involved in the cell cycle checkpoint and survival in response to ionizing radiation . Associates with chromatin to the CDC25B promoter .<BOP> | Q5VY09 |
Q8N0Y5 | OR8I2_HUMAN | Olfactory receptor OR11-170 | Homo | <M><A><G><N><N><F><T><E><V><T><V><F><I><L><S><G><F><A><N><H><P><E><L><Q><V><S><L><F><L><M><F><L><F><I><Y><L><F><T><V><L><G><N><L><G><L><I><T><L><I><R><M><D><S><Q><L><H><T><P><M><Y><F><F><L><S><N><L><A><F><I><D><I><F><Y><S><S><T><V><T><P><K><A><L><V><N><F><Q><S><N><R><R><S><I><S><F><V><G><C><F><V><Q><M><Y><F><F><V><G><L><V><C><C><E><C><F><L><L><G><S><M><A><Y><N><R><Y><I><A><I><C><N><P><L><L><Y><S><V><V><M><S><Q><K><V><S><N><W><L><G><V><M><P><Y><V><I><G><F><T><S><S><L><I><S><V><W><V><I><S><S><L><A><F><C><D><S><S><I><N><H><F><F><C><D><T><T><A><L><L><A><L><S><C><V><D><T><F><G><T><E><M><V><S><F><V><L><A><G><F><T><L><L><S><S><L><L><I><I><T><V><T><Y><I><I><I><I><S><A><I><L><R><I><Q><S><A><A><G><R><Q><K><A><F><S><T><C><A><S><H><L><M><A><V><T><I><F><Y><G><S><L><I><F><T><Y><L><Q><P><D><N><T><S><S><L><T><Q><A><Q><V><A><S><V><F><Y><T><I><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><N><A><L><L><R><V><I><H><R><K><L><F><P> | Odorant receptor.<BOP> | Q8N0Y5 |
Q86SF2 | GALT7_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 | Homo | <M><R><L><K><I><G><F><I><L><R><S><L><L><V><V><G><S><F><L><G><L><V><V><L><W><S><S><L><T><P><R><P><D><D><P><S><P><L><S><R><M><R><E><D><R><D><V><N><D><P><M><P><N><R><G><G><N><G><L><A><P><G><E><D><R><F><K><P><V><V><P><W><P><H><V><E><G><V><E><V><D><L><E><S><I><R><R><I><N><K><A><K><N><E><Q><E><H><H><A><G><G><D><S><Q><K><D><I><M><Q><R><Q><Y><L><T><F><K><P><Q><T><F><T><Y><H><D><P><V><L><R><P><G><I><L><G><N><F><E><P><K><E><P><E><P><P><G><V><V><G><G><P><G><E><K><A><K><P><L><V><L><G><P><E><F><K><Q><A><I><Q><A><S><I><K><E><F><G><F><N><M><V><A><S><D><M><I><S><L><D><R><S><V><N><D><L><R><Q><E><E><C><K><Y><W><H><Y><D><E><N><L><L><T><S><S><V><V><I><V><F><H><N><E><G><W><S><T><L><M><R><T><V><H><S><V><I><K><R><T><P><R><K><Y><L><A><E><I><V><L><I><D><D><F><S><N><K><E><H><L><K><E><K><L><D><E><Y><I><K><L><W><N><G><L><V><K><V><F><R><N><E><R><R><E><G><L><I><Q><A><R><S><I><G><A><Q><K><A><K><L><G><Q><V><L><I><Y><L><D><A><H><C><E><V><A><V><N><W><Y><A><P><L><V><A><P><I><S><K><D><R><T><I><C><T><V><P><L><I><D><V><I><N><G><N><T><Y><E><I><I><P><Q><G><G><G><D><E><D><G><Y><A><R><G><A><W><D><W><S><M><L><W><K><R><V><P><L><T><P><Q><E><K><R><L><R><K><T><K><T><E><P><Y><R><S><P><A><M><A><G><G><L><F><A><I><E><R><E><F><F><F><E><L><G><L><Y><D><P><G><L><Q><I><W><G><G><E><N><F><E><I><S><Y><K><I><W><Q><C><G><G><K><L><L><F><V><P><C><S><R><V><G><H><I><Y><R><L><E><G><W><Q><G><N><P><P><P><I><Y><V><G><S><S><P><T><L><K><N><Y><V><R><V><V><E><V><W><W><D><E><Y><K><D><Y><F><Y><A><S><R><P><E><S><Q><A><L><P><Y><G><D><I><S><E><L><K><K><F><R><E><D><H><N><C><K><S><F><K><W><F><M><E><E><I><A><Y><D><I><T><S><H><Y><P><L><P><P><K><N><V><D><W><G><E><I><R><G><F><E><T><A><Y><C><I><D><S><M><G><K><T><N><G><G><F><V><E><L><G><P><C><H><R><M><G><G><N><Q><L><F><R><I><N><E><A><N><Q><L><M><Q><Y><D><Q><C><L><T><K><G><A><D><G><S><K><V><M><I><T><H><C><N><L><N><E><F><K><E><W><Q><Y><F><K><N><L><H><R><F><T><H><I><P><S><G><K><C><L><D><R><S><E><V><L><H><Q><V><F><I><S><N><C><D><S><S><K><T><T><Q><K><W><E><M><N><N><I><H><S><V> | Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.<BOP> | Q86SF2 |
Q9NP61 | ARFG3_HUMAN | ADP-ribosylation factor GTPase-activating protein 3 | Homo | <M><G><D><P><S><K><Q><D><I><L><T><I><F><K><R><L><R><S><V><P><T><N><K><V><C><F><D><C><G><A><K><N><P><S><W><A><S><I><T><Y><G><V><F><L><C><I><D><C><S><G><S><H><R><S><L><G><V><H><L><S><F><I><R><S><T><E><L><D><S><N><W><S><W><F><Q><L><R><C><M><Q><V><G><G><N><A><S><A><S><S><F><F><H><Q><H><G><C><S><T><N><D><T><N><A><K><Y><N><S><R><A><A><Q><L><Y><R><E><K><I><K><S><L><A><S><Q><A><T><R><K><H><G><T><D><L><W><L><D><S><C><V><V><P><P><L><S><P><P><P><K><E><E><D><F><F><A><S><H><V><S><P><E><V><S><D><T><A><W><A><S><A><I><A><E><P><S><S><L><T><S><R><P><V><E><T><T><L><E><N><N><E><G><G><Q><E><Q><G><P><S><V><E><G><L><N><V><P><T><K><A><T><L><E><V><S><S><I><I><K><K><K><P><N><Q><A><K><K><G><L><G><A><K><K><G><S><L><G><A><Q><K><L><A><N><T><C><F><N><E><I><E><K><Q><A><Q><A><A><D><K><M><K><E><Q><E><D><L><A><K><V><V><S><K><E><E><S><I><V><S><S><L><R><L><A><Y><K><D><L><E><I><Q><M><K><K><D><E><K><M><N><I><S><G><K><K><N><V><D><S><D><R><L><G><M><G><F><G><N><C><R><S><V><I><S><H><S><V><T><S><D><M><Q><T><I><E><Q><E><S><P><I><M><A><K><P><R><K><K><Y><N><D><D><S><D><D><S><Y><F><T><S><S><S><S><Y><F><D><E><P><V><E><L><R><S><S><S><F><S><S><W><D><D><S><S><D><S><Y><W><K><K><E><T><S><K><D><T><E><T><V><L><K><T><T><G><Y><S><D><R><P><T><A><R><R><K><P><D><Y><E><P><V><E><N><T><D><E><A><Q><K><K><F><G><N><V><K><A><I><S><S><D><M><Y><F><G><R><Q><S><Q><A><D><Y><E><T><R><A><R><L><E><R><L><S><A><S><S><S><I><S><S><A><D><L><F><E><E><P><R><K><Q><P><A><G><N><Y><S><L><S><S><V><L><P><N><A><P><D><M><A><Q><F><K><Q><G><V><R><S><V><A><G><K><L><S><V><F><A><N><G><V><V><T><S><I><Q><D><R><Y><G><S> | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.<BOP> | Q9NP61 |
P09093 | CEL3A_HUMAN | Protease E | Homo | <M><M><L><R><L><L><S><S><L><L><L><V><A><V><A><S><G><Y><G><P><P><S><S><H><S><S><S><R><V><V><H><G><E><D><A><V><P><Y><S><W><P><W><Q><V><S><L><Q><Y><E><K><S><G><S><F><Y><H><T><C><G><G><S><L><I><A><P><D><W><V><V><T><A><G><H><C><I><S><R><D><L><T><Y><Q><V><V><L><G><E><Y><N><L><A><V><K><E><G><P><E><Q><V><I><P><I><N><S><E><E><L><F><V><H><P><L><W><N><R><S><C><V><A><C><G><N><D><I><A><L><I><K><L><S><R><S><A><Q><L><G><D><A><V><Q><L><A><S><L><P><P><A><G><D><I><L><P><N><K><T><P><C><Y><I><T><G><W><G><R><L><Y><T><N><G><P><L><P><D><K><L><Q><Q><A><R><L><P><V><V><D><Y><K><H><C><S><R><W><N><W><W><G><S><T><V><K><K><T><M><V><C><A><G><G><Y><I><R><S><G><C><N><G><D><S><G><G><P><L><N><C><P><T><E><D><G><G><W><Q><V><H><G><V><T><S><F><V><S><A><F><G><C><N><F><I><W><K><P><T><V><F><T><R><V><S><A><F><I><D><W><I><E><E><T><I><A><S><H> | Efficient protease with alanine specificity but only little elastolytic activity.<BOP> | P09093 |
Q9UNQ2 | DIM1_HUMAN | Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase | Homo | <M><P><K><V><K><S><G><A><I><G><R><R><R><G><R><Q><E><Q><R><R><E><L><K><S><A><G><G><L><M><F><N><T><G><I><G><Q><H><I><L><K><N><P><L><I><I><N><S><I><I><D><K><A><A><L><R><P><T><D><V><V><L><E><V><G><P><G><T><G><N><M><T><V><K><L><L><E><K><A><K><K><V><V><A><C><E><L><D><P><R><L><V><A><E><L><H><K><R><V><Q><G><T><P><V><A><S><K><L><Q><V><L><V><G><D><V><L><K><T><D><L><P><F><F><D><T><C><V><A><N><L><P><Y><Q><I><S><S><P><F><V><F><K><L><L><L><H><R><P><F><F><R><C><A><I><L><M><F><Q><R><E><F><A><L><R><L><V><A><K><P><G><D><K><L><Y><C><R><L><S><I><N><T><Q><L><L><A><R><V><D><H><L><M><K><V><G><K><N><N><F><R><P><P><P><K><V><E><S><S><V><V><R><I><E><P><K><N><P><P><P><P><I><N><F><Q><E><W><D><G><L><V><R><I><T><F><V><R><K><N><K><T><L><S><A><A><F><K><S><S><A><V><Q><Q><L><L><E><K><N><Y><R><I><H><C><S><V><H><N><I><I><I><P><E><D><F><S><I><A><D><K><I><Q><Q><I><L><T><S><T><G><F><S><D><K><R><A><R><S><M><D><I><D><D><F><I><R><L><L><H><G><F><N><A><E><G><I><H><F><S> | Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity .<BOP> | Q9UNQ2 |
Q9NY93 | DDX56_HUMAN | DEAD box protein 56 | Homo | <M><E><D><S><E><A><L><G><F><E><H><M><G><L><D><P><R><L><L><Q><A><V><T><D><L><G><W><S><R><P><T><L><I><Q><E><K><A><I><P><L><A><L><E><G><K><D><L><L><A><R><A><R><T><G><S><G><K><T><A><A><Y><A><I><P><M><L><Q><L><L><L><H><R><K><A><T><G><P><V><V><E><Q><A><V><R><G><L><V><L><V><P><T><K><E><L><A><R><Q><A><Q><S><M><I><Q><Q><L><A><T><Y><C><A><R><D><V><R><V><A><N><V><S><A><A><E><D><S><V><S><Q><R><A><V><L><M><E><K><P><D><V><V><V><G><T><P><S><R><I><L><S><H><L><Q><Q><D><S><L><K><L><R><D><S><L><E><L><L><V><V><D><E><A><D><L><L><F><S><F><G><F><E><E><E><L><K><S><L><L><C><H><L><P><R><I><Y><Q><A><F><L><M><S><A><T><F><N><E><D><V><Q><A><L><K><E><L><I><L><H><N><P><V><T><L><K><L><Q><E><S><Q><L><P><G><P><D><Q><L><Q><Q><F><Q><V><V><C><E><T><E><E><D><K><F><L><L><L><Y><A><L><L><K><L><S><L><I><R><G><K><S><L><L><F><V><N><T><L><E><R><S><Y><R><L><R><L><F><L><E><Q><F><S><I><P><T><C><V><L><N><G><E><L><P><L><R><S><R><C><H><I><I><S><Q><F><N><Q><G><F><Y><D><C><V><I><A><T><D><A><E><V><L><G><A><P><V><K><G><K><R><R><G><R><G><P><K><G><D><K><A><S><D><P><E><A><G><V><A><R><G><I><D><F><H><H><V><S><A><V><L><N><F><D><L><P><P><T><P><E><A><Y><I><H><R><A><G><R><T><A><R><A><N><N><P><G><I><V><L><T><F><V><L><P><T><E><Q><F><H><L><G><K><I><E><E><L><L><S><G><E><N><R><G><P><I><L><L><P><Y><Q><F><R><M><E><E><I><E><G><F><R><Y><R><C><R><D><A><M><R><S><V><T><K><Q><A><I><R><E><A><R><L><K><E><I><K><E><E><L><L><H><S><E><K><L><K><T><Y><F><E><D><N><P><R><D><L><Q><L><L><R><H><D><L><P><L><H><P><A><V><V><K><P><H><L><G><H><V><P><D><Y><L><V><P><P><A><L><R><G><L><V><R><P><H><K><K><R><K><K><L><S><S><S><C><R><K><A><K><R><A><K><S><Q><N><P><L><R><S><F><K><H><K><G><K><K><F><R><P><T><A><K><P><S> | May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.<BOP> | Q9NY93 |
Q96BS2 | CHP3_HUMAN | Tescalcin | Homo | <M><G><A><A><H><S><A><S><E><E><V><R><E><L><E><G><K><T><G><F><S><S><D><Q><I><E><Q><L><H><R><R><F><K><Q><L><S><G><D><Q><P><T><I><R><K><E><N><F><N><N><V><P><D><L><E><L><N><P><I><R><S><K><I><V><R><A><F><F><D><N><R><N><L><R><K><G><P><S><G><L><A><D><E><I><N><F><E><D><F><L><T><I><M><S><Y><F><R><P><I><D><T><T><M><D><E><E><Q><V><E><L><S><R><K><E><K><L><R><F><L><F><H><M><Y><D><S><D><S><D><G><R><I><T><L><E><E><Y><R><N><V><V><E><E><L><L><S><G><N><P><H><I><E><K><E><S><A><R><S><I><A><D><G><A><M><M><E><A><A><S><V><C><M><G><Q><M><E><P><D><Q><V><Y><E><G><I><T><F><E><D><F><L><K><I><W><Q><G><I><D><I><E><T><K><M><H><V><R><F><L><N><M><E><T><M><A><L><C><H> | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.<BOP> | Q96BS2 |
Q9H2K0 | IF3M_HUMAN | Translation initiation factor IF-3, mitochondrial | Homo | <M><A><A><L><F><L><K><R><L><T><L><Q><T><V><K><S><E><N><S><C><I><R><C><F><G><K><H><I><L><Q><K><T><A><P><A><Q><L><S><P><I><A><S><A><P><R><L><S><F><L><I><H><A><K><A><F><S><T><A><E><D><T><Q><N><E><G><K><K><T><K><K><N><K><T><A><F><S><N><V><G><R><K><I><S><Q><R><V><I><H><L><F><D><E><K><G><N><D><L><G><N><M><H><R><A><N><V><I><R><L><M><D><E><R><D><L><R><L><V><Q><R><N><T><S><T><E><P><A><E><Y><Q><L><M><T><G><L><Q><I><L><Q><E><R><Q><R><L><R><E><M><E><K><A><N><P><K><T><G><P><T><L><R><K><E><L><I><L><S><S><N><I><G><Q><H><D><L><D><T><K><T><K><Q><I><Q><Q><W><I><K><K><K><H><L><V><Q><I><T><I><K><K><G><K><N><V><D><V><S><E><N><E><M><E><E><I><F><H><Q><I><L><Q><T><M><P><G><I><A><T><F><S><S><R><P><Q><A><V><Q><G><G><K><A><L><M><C><V><L><R><A><F><S><K><N><E><E><K><A><Y><K><E><T><Q><E><T><Q><E><R><D><T><L><N><K><D><H><G><N><D><K><E><S><N><V><L><H><Q> | IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.<BOP> | Q9H2K0 |
Q5D1E8 | ZC12A_HUMAN | Zinc finger CCCH domain-containing protein 12A | Homo | <M><S><G><P><C><G><E><K><P><V><L><E><A><S><P><T><M><S><L><W><E><F><E><D><S><H><S><R><Q><G><T><P><R><P><G><Q><E><L><A><A><E><E><A><S><A><L><E><L><Q><M><K><V><D><F><F><R><K><L><G><Y><S><S><T><E><I><H><S><V><L><Q><K><L><G><V><Q><A><D><T><N><T><V><L><G><E><L><V><K><H><G><T><A><T><E><R><E><R><Q><T><S><P><D><P><C><P><Q><L><P><L><V><P><R><G><G><G><T><P><K><A><P><N><L><E><P><P><L><P><E><E><E><K><E><G><S><D><L><R><P><V><V><I><D><G><S><N><V><A><M><S><H><G><N><K><E><V><F><S><C><R><G><I><L><L><A><V><N><W><F><L><E><R><G><H><T><D><I><T><V><F><V><P><S><W><R><K><E><Q><P><R><P><D><V><P><I><T><D><Q><H><I><L><R><E><L><E><K><K><K><I><L><V><F><T><P><S><R><R><V><G><G><K><R><V><V><C><Y><D><D><R><F><I><V><K><L><A><Y><E><S><D><G><I><V><V><S><N><D><T><Y><R><D><L><Q><G><E><R><Q><E><W><K><R><F><I><E><E><R><L><L><M><Y><S><F><V><N><D><K><F><M><P><P><D><D><P><L><G><R><H><G><P><S><L><D><N><F><L><R><K><K><P><L><T><L><E><H><R><K><Q><P><C><P><Y><G><R><K><C><T><Y><G><I><K><C><R><F><F><H><P><E><R><P><S><C><P><Q><R><S><V><A><D><E><L><R><A><N><A><L><L><S><P><P><R><A><P><S><K><D><K><N><G><R><R><P><S><P><S><S><Q><S><S><S><L><L><T><E><S><E><Q><C><S><L><D><G><K><K><L><G><A><Q><A><S><P><G><S><R><Q><E><G><L><T><Q><T><Y><A><P><S><G><R><S><L><A><P><S><G><G><S><G><S><S><F><G><P><T><D><W><L><P><Q><T><L><D><S><L><P><Y><V><S><Q><D><C><L><D><S><G><I><G><S><L><E><S><Q><M><S><E><L><W><G><V><R><G><G><G><P><G><E><P><G><P><P><R><A><P><Y><T><G><Y><S><P><Y><G><S><E><L><P><A><T><A><A><F><S><A><F><G><R><A><M><G><A><G><H><F><S><V><P><A><D><Y><P><P><A><P><P><A><F><P><P><R><E><Y><W><S><E><P><Y><P><L><P><P><P><T><S><V><L><Q><E><P><P><V><Q><S><P><G><A><G><R><S><P><W><G><R><A><G><S><L><A><K><E><Q><A><S><V><Y><T><K><L><C><G><V><F><P><P><H><L><V><E><A><V><M><G><R><F><P><Q><L><L><D><P><Q><Q><L><A><A><E><I><L><S><Y><K><S><Q><H><P><S><E> | (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species.<BOP> | Q5D1E8 |
A0A0B4J1U4 | TRGV5_HUMAN | T cell receptor gamma variable 5 | Homo | <M><R><W><A><L><L><V><L><L><A><F><L><S><P><A><S><Q><K><S><S><N><L><E><G><G><T><K><S><V><T><R><P><T><R><S><S><A><E><I><T><C><D><L><T><V><I><N><A><F><Y><I><H><W><Y><L><H><Q><E><G><K><A><P><Q><R><L><L><Y><Y><D><V><S><N><S><K><D><V><L><E><S><G><L><S><P><G><K><Y><Y><T><H><T><P><R><R><W><S><W><I><L><I><L><R><N><L><I><E><N><D><S><G><V><Y><Y><C><A><T><W><D><R> | V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells . Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential | A0A0B4J1U4 |
Q96LB9 | PGRP3_HUMAN | Peptidoglycan recognition protein intermediate alpha | Homo | <M><G><T><L><P><W><L><L><A><F><F><I><L><G><L><Q><A><W><D><T><P><T><I><V><S><R><K><E><W><G><A><R><P><L><A><C><R><A><L><L><T><L><P><V><A><Y><I><I><T><D><Q><L><P><G><M><Q><C><Q><Q><Q><S><V><C><S><Q><M><L><R><G><L><Q><S><H><S><V><Y><T><I><G><W><C><D><V><A><Y><N><F><L><V><G><D><D><G><R><V><Y><E><G><V><G><W><N><I><Q><G><L><H><T><Q><G><Y><N><N><I><S><L><G><I><A><F><F><G><N><K><I><G><S><S><P><S><P><A><A><L><S><A><A><E><G><L><I><S><Y><A><I><Q><K><G><H><L><S><P><R><Y><I><Q><P><L><L><L><K><E><E><T><C><L><D><P><Q><H><P><V><M><P><R><K><V><C><P><N><I><I><K><R><S><A><W><E><A><R><E><T><H><C><P><K><M><N><L><P><A><K><Y><V><I><I><I><H><T><A><G><T><S><C><T><V><S><T><D><C><Q><T><V><V><R><N><I><Q><S><F><H><M><D><T><R><N><F><C><D><I><G><Y><H><F><L><V><G><Q><D><G><G><V><Y><E><G><V><G><W><H><I><Q><G><S><H><T><Y><G><F><N><D><I><A><L><G><I><A><F><I><G><Y><F><V><E><K><P><P><N><A><A><A><L><E><A><A><Q><D><L><I><Q><C><A><V><V><E><G><Y><L><T><P><N><Y><L><L><M><G><H><S><D><V><V><N><I><L><S><P><G><Q><A><L><Y><N><I><I><S><T><W><P><H><F><K><H> | Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.<BOP> | Q96LB9 |
Q03431 | PTH1R_HUMAN | Parathyroid hormone 1 receptor | Homo | <M><G><T><A><R><I><A><P><G><L><A><L><L><L><C><C><P><V><L><S><S><A><Y><A><L><V><D><A><D><D><V><M><T><K><E><E><Q><I><F><L><L><H><R><A><Q><A><Q><C><E><K><R><L><K><E><V><L><Q><R><P><A><S><I><M><E><S><D><K><G><W><T><S><A><S><T><S><G><K><P><R><K><D><K><A><S><G><K><L><Y><P><E><S><E><E><D><K><E><A><P><T><G><S><R><Y><R><G><R><P><C><L><P><E><W><D><H><I><L><C><W><P><L><G><A><P><G><E><V><V><A><V><P><C><P><D><Y><I><Y><D><F><N><H><K><G><H><A><Y><R><R><C><D><R><N><G><S><W><E><L><V><P><G><H><N><R><T><W><A><N><Y><S><E><C><V><K><F><L><T><N><E><T><R><E><R><E><V><F><D><R><L><G><M><I><Y><T><V><G><Y><S><V><S><L><A><S><L><T><V><A><V><L><I><L><A><Y><F><R><R><L><H><C><T><R><N><Y><I><H><M><H><L><F><L><S><F><M><L><R><A><V><S><I><F><V><K><D><A><V><L><Y><S><G><A><T><L><D><E><A><E><R><L><T><E><E><E><L><R><A><I><A><Q><A><P><P><P><P><A><T><A><A><A><G><Y><A><G><C><R><V><A><V><T><F><F><L><Y><F><L><A><T><N><Y><Y><W><I><L><V><E><G><L><Y><L><H><S><L><I><F><M><A><F><F><S><E><K><K><Y><L><W><G><F><T><V><F><G><W><G><L><P><A><V><F><V><A><V><W><V><S><V><R><A><T><L><A><N><T><G><C><W><D><L><S><S><G><N><K><K><W><I><I><Q><V><P><I><L><A><S><I><V><L><N><F><I><L><F><I><N><I><V><R><V><L><A><T><K><L><R><E><T><N><A><G><R><C><D><T><R><Q><Q><Y><R><K><L><L><K><S><T><L><V><L><M><P><L><F><G><V><H><Y><I><V><F><M><A><T><P><Y><T><E><V><S><G><T><L><W><Q><V><Q><M><H><Y><E><M><L><F><N><S><F><Q><G><F><F><V><A><I><I><Y><C><F><C><N><G><E><V><Q><A><E><I><K><K><S><W><S><R><W><T><L><A><L><D><F><K><R><K><A><R><S><G><S><S><S><Y><S><Y><G><P><M><V><S><H><T><S><V><T><N><V><G><P><R><V><G><L><G><L><P><L><S><P><R><L><L><P><T><A><T><T><N><G><H><P><Q><L><P><G><H><A><K><P><G><T><P><A><L><E><T><L><E><T><T><P><P><A><M><A><A><P><K><D><D><G><F><L><N><G><S><C><S><G><L><D><E><E><A><S><G><P><E><R><P><P><A><L><L><Q><E><E><W><E><T><V><M> | Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<BOP> | Q03431 |
Q7L945 | ZN627_HUMAN | Zinc finger protein 627 | Homo | <M><D><S><V><A><F><E><D><V><A><V><N><F><T><L><E><E><W><A><L><L><D><P><S><Q><K><N><L><Y><R><D><V><M><R><E><T><F><R><N><L><A><S><V><G><K><Q><W><E><D><Q><N><I><E><D><P><F><K><I><P><R><R><N><I><S><H><I><P><E><R><L><C><E><S><K><E><G><G><Q><G><E><E><T><F><S><Q><I><P><D><G><I><L><N><K><K><T><P><G><V><K><P><C><E><S><S><V><C><G><E><V><G><M><G><P><S><S><L><N><R><H><I><R><D><H><T><G><R><E><P><N><E><Y><Q><E><Y><G><K><K><S><Y><T><R><N><Q><C><G><R><A><L><S><Y><H><R><S><F><P><V><R><E><R><T><H><P><G><G><K><P><Y><D><C><K><E><C><G><E><T><F><I><S><L><V><S><I><R><R><H><M><L><T><H><R><G><G><V><P><Y><K><C><K><V><C><G><K><A><F><D><Y><P><S><L><F><R><I><H><E><R><S><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><C><S><S><Y><I><R><I><H><E><R><T><H><T><G><D><K><P><Y><E><C><K><Q><C><G><K><A><F><S><C><S><K><Y><I><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><C><A><S><S><V><R><S><H><E><R><T><H><T><G><E><K><L><F><E><C><K><E><C><G><K><A><L><T><C><L><A><S><V><R><R><H><M><I><K><H><T><G><N><G><P><Y><K><C><K><V><C><G><K><A><F><D><F><P><S><S><F><R><I><H><E><R><T><H><T><G><E><K><P><Y><D><C><K><Q><C><G><K><A><F><S><C><S><S><S><F><R><K><H><E><R><I><H><T><G><E><K><P><Y><K><C><T><K><C><G><K><A><F><S><R><S><S><Y><F><R><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><S><R><S><T><Y><F><R><V><H><E><K><I><H><T><G><E><K><P><Y><E><N><P><N><P><N><A><S><V><V><P><V><L><S> | May be involved in transcriptional regulation.<BOP> | Q7L945 |
A6NIM6 | S15A5_HUMAN | Solute carrier family 15 member 5 | Homo | <M><S><V><T><G><F><T><I><T><D><E><K><V><H><L><Y><H><S><I><E><K><E><K><T><V><R><H><I><G><D><L><C><S><S><H><S><V><K><K><I><Q><V><G><I><C><L><L><L><V><E><L><C><E><R><F><T><F><F><E><V><V><C><N><M><I><P><F><C><T><I><K><L><G><Y><H><N><C><Q><A><A><I><L><N><L><C><F><I><G><T><S><I><L><T><P><V><F><V><R><W><L><T><D><V><Y><L><G><R><N><K><L><V><Y><I><C><L><F><L><H><F><L><G><T><A><L><L><S><V><V><A><F><P><L><E><D><F><Y><L><G><T><Y><H><A><V><N><N><I><P><K><T><E><Q><H><R><L><F><Y><V><A><L><L><T><I><C><L><G><I><G><G><V><R><A><I><V><C><P><L><G><A><F><G><L><Q><E><Y><G><S><Q><K><T><M><S><F><F><N><W><F><Y><W><L><M><N><L><N><A><T><I><V><F><L><G><I><S><Y><I><Q><H><S><Q><A><W><A><L><V><L><L><I><P><F><M><S><M><L><M><A><V><I><T><L><H><M><I><Y><Y><N><L><I><Y><Q><S><E><K><R><C><S><L><L><T><G><V><G><V><L><V><S><A><L><K><T><C><H><P><Q><Y><C><H><L><G><R><D><V><T><S><Q><L><D><H><A><K><E><K><N><G><G><C><Y><S><E><L><H><V><E><D><T><T><F><F><L><T><L><L><P><L><F><I><F><Q><L><L><Y><R><M><C><I><M><Q><I><P><S><G><Y><Y><L><Q><T><M><N><S><N><L><N><L><D><G><F><L><L><P><I><A><V><M><N><A><I><S><S><L><P><L><L><I><L><A><P><F><L><E><Y><F><S><T><C><L><F><P><S><K><R><V><G><S><F><L><S><T><C><I><I><A><G><N><L><F><A><A><L><S><V><M><I><A><G><F><F><E><I><H><R><K><H><F><P><A><V><E><Q><P><L><S><G><K><V><L><T><V><S><S><M><P><C><F><Y><L><I><L><Q><Y><V><L><L><G><V><A><E><T><L><V><N><P><A><L><S><V><I><S><Y><R><F><V><P><S><N><V><R><G><T><S><M><N><F><L><T><L><F><N><G><F><G><C><F><T><G><A><L><L><V><K><L><V><Y><L><I><S><D><G><N><W><F><P><N><T><L><N><K><G><N><L><E><S><F><F><F><F><L><A><S><L><T><L><L><N><V><L><G><F><C><S><V><S><Q><R><Y><C><N><L><N><H><F><N><A><Q><N><I><R><G><S><N><L><E><E><T><L><L><L><H><E><K><S><L><K><F><Y><G><S><I><Q><E><F><S><S><S><I><D><L><W><E><T><A><L> | Proton oligopeptide cotransporter.<BOP> | A6NIM6 |
O14737 | PDCD5_HUMAN | TF-1 cell apoptosis-related protein 19 | Homo | <M><A><D><E><E><L><E><A><L><R><R><Q><R><L><A><E><L><Q><A><K><H><G><D><P><G><D><A><A><Q><Q><E><A><K><H><R><E><A><E><M><R><N><S><I><L><A><Q><V><L><D><Q><S><A><R><A><R><L><S><N><L><A><L><V><K><P><E><K><T><K><A><V><E><N><Y><L><I><Q><M><A><R><Y><G><Q><L><S><E><K><V><S><E><Q><G><L><I><E><I><L><K><K><V><S><Q><Q><T><E><K><T><T><T><V><K><F><N><R><R><K><V><M><D><S><D><E><D><D><D><Y> | May function in the process of apoptosis.<BOP> | O14737 |
P40937 | RFC5_HUMAN | Replication factor C 36 kDa subunit | Homo | <M><E><T><S><A><L><K><Q><Q><E><Q><P><A><A><T><K><I><R><N><L><P><W><V><E><K><Y><R><P><Q><T><L><N><D><L><I><S><H><Q><D><I><L><S><T><I><Q><K><F><I><N><E><D><R><L><P><H><L><L><L><Y><G><P><P><G><T><G><K><T><S><T><I><L><A><C><A><K><Q><L><Y><K><D><K><E><F><G><S><M><V><L><E><L><N><A><S><D><D><R><G><I><D><I><I><R><G><P><I><L><S><F><A><S><T><R><T><I><F><K><K><G><F><K><L><V><I><L><D><E><A><D><A><M><T><Q><D><A><Q><N><A><L><R><R><V><I><E><K><F><T><E><N><T><R><F><C><L><I><C><N><Y><L><S><K><I><I><P><A><L><Q><S><R><C><T><R><F><R><F><G><P><L><T><P><E><L><M><V><P><R><L><E><H><V><V><E><E><E><K><V><D><I><S><E><D><G><M><K><A><L><V><T><L><S><S><G><D><M><R><R><A><L><N><I><L><Q><S><T><N><M><A><F><G><K><V><T><E><E><T><V><Y><T><C><T><G><H><P><L><K><S><D><I><A><N><I><L><D><W><M><L><N><Q><D><F><T><T><A><Y><R><N><I><T><E><L><K><T><L><K><G><L><A><L><H><D><I><L><T><E><I><H><L><F><V><H><R><V><D><F><P><S><S><V><R><I><H><L><L><T><K><M><A><D><I><E><Y><R><L><S><V><G><T><N><E><K><I><Q><L><S><S><L><I><A><A><F><Q><V><T><R><D><L><I><V><A><E><A> | The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.<BOP> | P40937 |
O75474 | FRAT2_HUMAN | Frequently rearranged in advanced T-cell lymphomas 2 | Homo | <M><P><C><R><R><E><E><E><E><E><A><G><E><E><A><E><G><E><E><E><E><D><D><S><F><L><L><L><Q><Q><S><V><T><L><G><S><S><G><E><V><D><R><L><V><A><Q><I><G><E><T><L><Q><L><D><A><A><Q><D><S><P><A><S><P><C><A><P><P><G><V><P><L><R><A><P><G><P><L><A><A><A><V><P><A><D><K><A><R><P><P><A><V><P><L><L><L><P><P><A><S><A><E><T><V><G><P><A><P><S><G><A><L><R><C><A><L><G><D><R><G><R><V><R><G><R><A><A><P><Y><C><V><A><E><V><A><A><G><P><S><A><L><P><G><P><C><R><R><G><W><L><R><D><A><V><T><S><R><R><L><Q><Q><R><R><W><T><Q><A><G><A><R><A><G><D><D><D><P><H><R><L><L><Q><Q><L><V><L><S><G><N><L><I><K><E><A><V><R><R><L><Q><R><A><V><A><A><V><A><A><T><G><P><A><S><A><P><G><P><G><G><G><R><S><G><P><D><R><I><A><L><Q><P><S><G><S><L><L> | Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.<BOP> | O75474 |
P23919 | KTHY_HUMAN | dTMP kinase | Homo | <M><A><A><R><R><G><A><L><I><V><L><E><G><V><D><R><A><G><K><S><T><Q><S><R><K><L><V><E><A><L><C><A><A><G><H><R><A><E><L><L><R><F><P><E><R><S><T><E><I><G><K><L><L><S><S><Y><L><Q><K><K><S><D><V><E><D><H><S><V><H><L><L><F><S><A><N><R><W><E><Q><V><P><L><I><K><E><K><L><S><Q><G><V><T><L><V><V><D><R><Y><A><F><S><G><V><A><F><T><G><A><K><E><N><F><S><L><D><W><C><K><Q><P><D><V><G><L><P><K><P><D><L><V><L><F><L><Q><L><Q><L><A><D><A><A><K><R><G><A><F><G><H><E><R><Y><E><N><G><A><F><Q><E><R><A><L><R><C><F><H><Q><L><M><K><D><T><T><L><N><W><K><M><V><D><A><S><K><S><I><E><A><V><H><E><D><I><R><V><L><S><E><D><A><I><R><T><A><T><E><K><P><L><G><E><L><W><K> | Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).<BOP> | P23919 |
Q8IV04 | TB10C_HUMAN | TBC1 domain family member 10C | Homo | <M><A><Q><A><L><G><E><D><L><V><Q><P><P><E><L><Q><D><D><S><S><S><L><G><S><D><S><E><L><S><G><P><G><P><Y><R><Q><A><D><R><Y><G><F><I><G><G><S><S><A><E><P><G><P><G><H><P><P><A><D><L><I><R><Q><R><E><M><K><W><V><E><M><T><S><H><W><E><K><T><M><S><R><R><Y><K><K><V><K><M><Q><C><R><K><G><I><P><S><A><L><R><A><R><C><W><P><L><L><C><G><A><H><V><C><Q><K><N><S><P><G><T><Y><Q><E><L><A><E><A><P><G><D><P><Q><W><M><E><T><I><G><R><D><L><H><R><Q><F><P><L><H><E><M><F><V><S><P><Q><G><H><G><Q><Q><G><L><L><Q><V><L><K><A><Y><T><L><Y><R><P><E><Q><G><Y><C><Q><A><Q><G><P><V><A><A><V><L><L><M><H><L><P><P><E><E><A><F><W><C><L><V><Q><I><C><E><V><Y><L><P><G><Y><Y><G><P><H><M><E><A><V><R><L><D><A><E><V><F><M><A><L><L><R><R><L><L><P><H><V><H><K><H><L><Q><Q><V><G><V><G><P><L><L><Y><L><P><E><W><F><L><C><L><F><A><R><S><L><P><F><P><T><V><L><R><V><W><D><A><F><L><S><E><G><A><R><V><L><F><R><V><G><L><T><L><V><R><L><A><L><G><T><A><E><Q><R><G><A><C><P><G><L><L><E><T><L><G><A><L><R><A><I><P><P><A><Q><L><Q><E><E><A><F><M><S><Q><V><H><S><V><V><L><S><E><R><D><L><Q><R><E><I><K><A><Q><L><A><Q><L><P><D><S><A><P><G><P><P><P><R><P><Q><V><R><L><A><G><A><Q><A><I><F><E><A><Q><Q><L><A><G><V><R><R><G><A><K><P><E><V><P><R><I><V><V><Q><P><P><E><E><P><R><P><P><R><R><K><P><Q><T><R><G><K><T><F><H><G><L><L><T><R><A><R><G><P><P><I><E><G><P><P><R><P><Q><R><G><S><T><S><F><L><D><T><R><F> | Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.<BOP> | Q8IV04 |
Q8NDQ6 | ZN540_HUMAN | Zinc finger protein 540 | Homo | <M><A><H><A><L><V><T><F><R><D><V><A><I><D><F><S><Q><K><E><W><E><C><L><D><T><T><Q><R><K><L><Y><R><D><V><M><L><E><N><Y><N><N><L><V><S><L><G><Y><S><G><S><K><P><D><V><I><T><L><L><E><Q><G><K><E><P><C><V><V><A><R><D><V><T><G><R><Q><C><P><G><L><L><S><R><H><K><T><K><K><L><S><S><E><K><D><I><H><E><I><S><L><S><K><E><S><I><I><E><K><S><K><T><L><R><L><K><G><S><I><F><R><N><E><W><Q><N><K><S><E><F><E><G><Q><Q><G><L><K><E><R><S><I><S><Q><K><K><I><V><S><K><K><M><S><T><D><R><K><R><P><S><F><T><L><N><Q><R><I><H><N><S><E><K><S><C><D><S><H><L><V><Q><H><G><K><I><D><S><D><V><K><H><D><C><K><E><C><G><S><T><F><N><N><V><Y><Q><L><T><L><H><Q><K><I><H><T><G><E><K><S><C><K><C><E><K><C><G><K><V><F><S><H><S><Y><Q><L><T><L><H><Q><R><F><H><T><G><E><K><P><Y><E><C><Q><E><C><G><K><T><F><T><L><Y><P><Q><L><N><R><H><Q><K><I><H><T><G><K><K><P><Y><M><C><K><K><C><D><K><G><F><F><S><R><L><E><L><T><Q><H><K><R><I><H><T><G><K><K><S><Y><E><C><K><E><C><G><K><V><F><Q><L><I><F><Y><F><K><E><H><E><R><I><H><T><G><K><K><P><Y><E><C><K><E><C><G><K><A><F><S><V><C><G><Q><L><T><R><H><Q><K><I><H><T><G><V><K><P><Y><E><C><K><E><C><G><K><T><F><R><L><S><F><Y><L><T><E><H><R><R><T><H><A><G><K><K><P><Y><E><C><K><E><C><G><K><S><F><N><V><R><G><Q><L><N><R><H><K><T><I><H><T><G><I><K><P><F><A><C><K><V><C><E><K><A><F><S><Y><S><G><D><L><R><V><H><S><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><M><L><R><S><V><L><T><E><H><Q><R><L><H><T><G><V><K><P><Y><E><C><K><E><C><G><K><T><F><R><V><R><S><Q><I><S><L><H><K><K><I><H><T><D><V><K><P><Y><K><C><V><R><C><G><K><T><F><R><F><G><F><Y><L><T><E><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><I><R><R><G><N><L><K><E><H><L><K><I><H><S><G><L><K><P><Y><D><C><K><E><C><G><K><S><F><S><R><R><G><Q><F><T><E><H><Q><K><I><H><T><G><V><K><P><Y><K><C><K><E><C><G><K><A><F><S><R><S><V><D><L><R><I><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><L><N><S><H><L><T><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><V><C><R><K><A><F><R><Q><Y><S><H><L><Y><Q><H><Q><K><T><H><N><V><I> | May act as a transcriptional repressor.<BOP> | Q8NDQ6 |
Q52LD8 | RFTN2_HUMAN | Raft-linking protein 2 | Homo | <M><G><C><G><L><R><K><L><E><D><P><D><D><S><S><P><G><K><I><F><S><T><L><K><R><P><Q><V><E><T><K><T><E><F><A><Y><E><Y><V><L><L><D><F><T><L><Q><A><S><S><N><P><E><V><I><K><I><N><S><I><L><D><I><V><T><K><V><E><N><Y><Y><L><K><G><Y><I><V><G><A><I><H><P><V><I><Q><P><V><G><Q><R><K><H><L><P><A><S><Y><L><Y><R><V><V><L><L><R><L><K><L><S><P><K><N><S><A><A><P><S><G><Q><R><R><P><R><L><V><I><E><E><C><P><L><T><S><E><A><Q><T><N><D><A><A><K><E><L><I><E><K><I><N><V><A><A><K><R><G><M><K><F><V><G><F><I><S><Q><H><Y><S><P><S><K><F><C><N><G><T><N><H><D><G><D><I><E><S><M><L><H><V><R><H><G><S><D><E><N><C><R><S><W><N><E><G><T><L><S><G><Q><S><S><E><S><G><I><E><E><E><L><H><H><E><S><G><Q><Y><Q><M><E><Q><N><G><S><P><T><S><S><K><S><R><K><G><E><A><S><D><N><K><L><Y><T><V><F><N><A><F><D><D><D><S><T><S><W><A><Y><Q><E><G><I><L><S><M><K><V><T><R><K><G><S><V><I><S><T><L><D><A><D><W><L><E><L><T><T><F><Y><Y><K><Q><G><L><S><L><I><D><S><F><V><F><W><E><T><S><K><G><E><H><L><P><K><S><L><E><G><F><F><I><Y><E><E><E><G><S><G><V><P><G><S><S><R><K><G><N><D><A><I><V><V><E><Q><W><T><V><I><E><G><C><E><I><K><T><D><Y><G><P><L><L><H><T><L><A><E><F><G><W><L><L><T><S><V><L><P><T><P><V><L><R><H><D><S><E><G><N><L><A><T><K><Q><I><V><F><L><Q><R><P><V><M><W><N><S><A><A><Q><T><P><D><K><K><A><S><R><H><I><K><G><E><D><K><N><K><A><T><S><R><S><I><G><L><D><T><T><S><S><Q><P><A><E><S><R><H><L><P><E><E><C><R><L><S><P><S><R><E><C><W><T><K><E><G><R><L><A><Q><H><N><S><F><S><G><F><S><S><S><D><N><V><L><R><E><L><D><D><G><Q><F><D><Q><E><D><G><V><T><Q><V><T><C><M> | Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.<BOP> | Q52LD8 |
P62191 | PRS4_HUMAN | Proteasome 26S subunit ATPase 1 | Homo | <M><G><Q><S><Q><S><G><G><H><G><P><G><G><G><K><K><D><D><K><D><K><K><K><K><Y><E><P><P><V><P><T><R><V><G><K><K><K><K><K><T><K><G><P><D><A><A><S><K><L><P><L><V><T><P><H><T><Q><C><R><L><K><L><L><K><L><E><R><I><K><D><Y><L><L><M><E><E><E><F><I><R><N><Q><E><Q><M><K><P><L><E><E><K><Q><E><E><E><R><S><K><V><D><D><L><R><G><T><P><M><S><V><G><T><L><E><E><I><I><D><D><N><H><A><I><V><S><T><S><V><G><S><E><H><Y><V><S><I><L><S><F><V><D><K><D><L><L><E><P><G><C><S><V><L><L><N><H><K><V><H><A><V><I><G><V><L><M><D><D><T><D><P><L><V><T><V><M><K><V><E><K><A><P><Q><E><T><Y><A><D><I><G><G><L><D><N><Q><I><Q><E><I><K><E><S><V><E><L><P><L><T><H><P><E><Y><Y><E><E><M><G><I><K><P><P><K><G><V><I><L><Y><G><P><P><G><T><G><K><T><L><L><A><K><A><V><A><N><Q><T><S><A><T><F><L><R><V><V><G><S><E><L><I><Q><K><Y><L><G><D><G><P><K><L><V><R><E><L><F><R><V><A><E><E><H><A><P><S><I><V><F><I><D><E><I><D><A><I><G><T><K><R><Y><D><S><N><S><G><G><E><R><E><I><Q><R><T><M><L><E><L><L><N><Q><L><D><G><F><D><S><R><G><D><V><K><V><I><M><A><T><N><R><I><E><T><L><D><P><A><L><I><R><P><G><R><I><D><R><K><I><E><F><P><L><P><D><E><K><T><K><K><R><I><F><Q><I><H><T><S><R><M><T><L><A><D><D><V><T><L><D><D><L><I><M><A><K><D><D><L><S><G><A><D><I><K><A><I><C><T><E><A><G><L><M><A><L><R><E><R><R><M><K><V><T><N><E><D><F><K><K><S><K><E><N><V><L><Y><K><K><Q><E><G><T><P><E><G><L><Y><L> | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.<BOP> | P62191 |
P23760 | PAX3_HUMAN | HuP2 | Homo | <M><T><T><L><A><G><A><V><P><R><M><M><R><P><G><P><G><Q><N><Y><P><R><S><G><F><P><L><E><V><S><T><P><L><G><Q><G><R><V><N><Q><L><G><G><V><F><I><N><G><R><P><L><P><N><H><I><R><H><K><I><V><E><M><A><H><H><G><I><R><P><C><V><I><S><R><Q><L><R><V><S><H><G><C><V><S><K><I><L><C><R><Y><Q><E><T><G><S><I><R><P><G><A><I><G><G><S><K><P><K><Q><V><T><T><P><D><V><E><K><K><I><E><E><Y><K><R><E><N><P><G><M><F><S><W><E><I><R><D><K><L><L><K><D><A><V><C><D><R><N><T><V><P><S><V><S><S><I><S><R><I><L><R><S><K><F><G><K><G><E><E><E><E><A><D><L><E><R><K><E><A><E><E><S><E><K><K><A><K><H><S><I><D><G><I><L><S><E><R><A><S><A><P><Q><S><D><E><G><S><D><I><D><S><E><P><D><L><P><L><K><R><K><Q><R><R><S><R><T><T><F><T><A><E><Q><L><E><E><L><E><R><A><F><E><R><T><H><Y><P><D><I><Y><T><R><E><E><L><A><Q><R><A><K><L><T><E><A><R><V><Q><V><W><F><S><N><R><R><A><R><W><R><K><Q><A><G><A><N><Q><L><M><A><F><N><H><L><I><P><G><G><F><P><P><T><A><M><P><T><L><P><T><Y><Q><L><S><E><T><S><Y><Q><P><T><S><I><P><Q><A><V><S><D><P><S><S><T><V><H><R><P><Q><P><L><P><P><S><T><V><H><Q><S><T><I><P><S><N><P><D><S><S><S><A><Y><C><L><P><S><T><R><H><G><F><S><S><Y><T><D><S><F><V><P><P><S><G><P><S><N><P><M><N><P><T><I><G><N><G><L><S><P><Q><V><M><G><L><L><T><N><H><G><G><V><P><H><Q><P><Q><T><D><Y><A><L><S><P><L><T><G><G><L><E><P><T><T><T><V><S><A><S><C><S><Q><R><L><D><H><M><K><S><L><D><S><L><P><T><S><Q><S><Y><C><P><P><T><Y><S><T><T><G><Y><S><M><D><P><V><T><G><Y><Q><Y><G><Q><Y><G><Q><S><K><P><W><T><F> | Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 .<BOP> | P23760 |
Q9HBU9 | POPD2_HUMAN | Popeye domain-containing protein 2 | Homo | <M><S><A><N><S><S><R><V><G><Q><L><L><L><Q><G><S><A><C><I><R><W><K><Q><D><V><E><G><A><V><Y><H><L><A><N><C><L><L><L><L><G><F><M><G><G><S><G><V><Y><G><C><F><Y><L><F><G><F><L><S><A><G><Y><L><C><C><V><L><W><G><W><F><S><A><C><G><L><D><I><V><L><W><S><F><L><L><A><V><V><C><L><L><Q><L><A><H><L><V><Y><R><L><R><E><D><T><L><P><E><E><F><D><L><L><Y><K><T><L><C><L><P><L><Q><V><P><L><Q><T><Y><K><E><I><V><H><C><C><E><E><Q><V><L><T><L><A><T><E><Q><T><Y><A><V><E><G><E><T><P><I><N><R><L><S><L><L><L><S><G><R><V><R><V><S><Q><D><G><Q><F><L><H><Y><I><F><P><Y><Q><F><M><D><S><P><E><W><E><S><L><Q><P><S><E><E><G><V><F><Q><V><T><L><T><A><E><T><S><C><S><Y><I><S><W><P><R><K><S><L><H><L><L><L><T><K><E><R><Y><I><S><C><L><F><S><A><L><L><G><Y><D><I><S><E><K><L><Y><T><L><N><D><K><L><F><A><K><F><G><L><R><F><D><I><R><L><P><S><L><Y><H><V><L><G><P><T><A><A><D><A><G><P><E><S><E><K><G><D><E><E><V><C><E><P><A><V><S><P><P><Q><A><T><P><T><S><L><Q><Q><T><P><P><C><S><T><P><P><A><T><T><N><F><P><A><P><P><T><R><A><R><L><S><R><P><D><S><G><I><L><A><S><R><I><P><L><Q><S><Y><S><Q><V><I><S><R><G><Q><A><P><L><A><P><T><H><T><P><E><L> | Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.<BOP> | Q9HBU9 |
Q96K37 | S35E1_HUMAN | Solute carrier family 35 member E1 | Homo | <M><A><A><A><A><V><G><A><G><H><G><A><G><G><P><G><A><A><S><S><S><G><G><A><R><E><G><A><R><V><A><A><L><C><L><L><W><Y><A><L><S><A><G><G><N><V><V><N><K><V><I><L><S><A><F><P><F><P><V><T><V><S><L><C><H><I><L><A><L><C><A><G><L><P><P><L><L><R><A><W><R><V><P><P><A><P><P><V><S><G><P><G><P><S><P><H><P><S><S><G><P><L><L><P><P><R><F><Y><P><R><Y><V><L><P><L><A><F><G><K><Y><F><A><S><V><S><A><H><V><S><I><W><K><V><P><V><S><Y><A><H><T><V><K><A><T><M><P><I><W><V><V><L><L><S><R><I><I><M><K><E><K><Q><S><T><K><V><Y><L><S><L><I><P><I><I><S><G><V><L><L><A><T><V><T><E><L><S><F><D><M><W><G><L><V><S><A><L><A><A><T><L><C><F><S><L><Q><N><I><F><S><K><K><V><L><R><D><S><R><I><H><H><L><R><L><L><N><I><L><G><C><H><A><V><F><F><M><I><P><T><W><V><L><V><D><L><S><A><F><L><V><S><S><D><L><T><Y><V><Y><Q><W><P><W><T><L><L><L><L><A><V><S><G><F><C><N><F><A><Q><N><V><I><A><F><S><I><L><N><L><V><S><P><L><S><Y><S><V><A><N><A><T><K><R><I><M><V><I><T><V><S><L><I><M><L><R><N><P><V><T><S><T><N><V><L><G><M><M><T><A><I><L><G><V><F><L><Y><N><K><T><K><Y><D><A><N><Q><Q><A><R><K><H><L><L><P><V><T><T><A><D><L><S><S><K><E><R><H><R><S><P><L><E><K><P><H><N><G><L><L><F><P><Q><H><G><D><Y><Q><Y><G><R><N><N><I><L><T><D><H><F><Q><Y><S><R><Q><S><Y><P><N><S><Y><S><L><N><R><Y><D><V> | Putative transporter.<BOP> | Q96K37 |
Q13530 | SERC3_HUMAN | Tumor differentially expressed protein 1 | Homo | <M><G><A><V><L><G><V><F><S><L><A><S><W><V><P><C><L><C><S><G><A><S><C><L><L><C><S><C><C><P><N><S><K><N><S><T><V><T><R><L><I><Y><A><F><I><L><L><L><S><T><V><V><S><Y><I><M><Q><R><K><E><M><E><T><Y><L><K><K><I><P><G><F><C><E><G><G><F><K><I><H><E><A><D><I><N><A><D><K><D><C><D><V><L><V><G><Y><K><A><V><Y><R><I><S><F><A><M><A><I><F><F><F><V><F><S><L><L><M><F><K><V><K><T><S><K><D><L><R><A><A><V><H><N><G><F><W><F><F><K><I><A><A><L><I><G><I><M><V><G><S><F><Y><I><P><G><G><Y><F><S><S><V><W><F><V><V><G><M><I><G><A><A><L><F><I><L><I><Q><L><V><L><L><V><D><F><A><H><S><W><N><E><S><W><V><N><R><M><E><E><G><N><P><R><L><W><Y><A><A><L><L><S><F><T><S><A><F><Y><I><L><S><I><I><C><V><G><L><L><Y><T><Y><Y><T><K><P><D><G><C><T><E><N><K><F><F><I><S><I><N><L><I><L><C><V><V><A><S><I><I><S><I><H><P><K><I><Q><E><H><Q><P><R><S><G><L><L><Q><S><S><L><I><T><L><Y><T><M><Y><L><T><W><S><A><M><S><N><E><P><D><R><S><C><N><P><N><L><M><S><F><I><T><R><I><T><A><P><T><L><A><P><G><N><S><T><A><V><V><P><T><P><T><P><P><S><K><S><G><S><L><L><D><S><D><N><F><I><G><L><F><V><F><V><L><C><L><L><Y><S><S><I><R><T><S><T><N><S><Q><V><D><K><L><T><L><S><G><S><D><S><V><I><L><G><D><T><T><T><S><G><A><S><D><E><E><D><G><Q><P><R><R><A><V><D><N><E><K><E><G><V><Q><Y><S><Y><S><L><F><H><L><M><L><C><L><A><S><L><Y><I><M><M><T><L><T><S><W><Y><S><P><D><A><K><F><Q><S><M><T><S><K><W><P><A><V><W><V><K><I><S><S><S><W><V><C><L><L><L><Y><V><W><T><L><V><A><P><L><V><L><T><S><R><D><F><S> | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm .<BOP> | Q13530 |
P15515 | HIS1_HUMAN | Histatin-2 | Homo | <M><K><F><F><V><F><A><L><V><L><A><L><M><I><S><M><I><S><A><D><S><H><E><K><R><H><H><G><Y><R><R><K><F><H><E><K><H><H><S><H><R><E><F><P><F><Y><G><D><Y><G><S><N><Y><L><Y><D><N> | Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.<BOP> | P15515 |
Q9GZY8 | MFF_HUMAN | Mitochondrial fission factor | Homo | <M><S><K><G><T><S><S><D><T><S><L><G><R><V><S><R><A><A><F><P><S><P><T><A><A><E><M><A><E><I><S><R><I><Q><Y><E><M><E><Y><T><E><G><I><S><Q><R><M><R><V><P><E><K><L><K><V><A><P><P><N><A><D><L><E><Q><G><F><Q><E><G><V><P><N><A><S><V><I><M><Q><V><P><E><R><I><V><V><A><G><N><N><E><D><V><S><F><S><R><P><A><D><L><D><L><I><Q><S><T><P><F><K><P><L><A><L><K><T><P><P><R><V><L><T><L><S><E><R><P><L><D><F><L><D><L><E><R><P><P><T><T><P><Q><N><E><E><I><R><A><V><G><R><L><K><R><E><R><S><M><S><E><N><A><V><R><Q><N><G><Q><L><V><R><N><D><S><L><W><H><R><S><D><S><A><P><R><N><K><I><S><R><F><Q><A><P><I><S><A><P><E><Y><T><V><T><P><S><P><Q><Q><A><R><V><C><P><P><H><M><L><P><E><D><G><A><N><L><S><S><A><R><G><I><L><S><L><I><Q><S><S><T><R><R><A><Y><Q><Q><I><L><D><V><L><D><E><N><R><R><P><V><L><R><G><G><S><A><A><A><T><S><N><P><H><H><D><N><V><R><Y><G><I><S><N><I><D><T><T><I><E><G><T><S><D><D><L><T><V><V><D><A><A><S><L><R><R><Q><I><I><K><L><N><R><R><L><Q><L><L><E><E><E><N><K><E><R><A><K><R><E><M><V><M><Y><S><I><T><V><A><F><W><L><L><N><S><W><L><W><F><R><R> | Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.<BOP> | Q9GZY8 |
Q96KJ9 | COX42_HUMAN | Cytochrome c oxidase subunit IV isoform 2 | Homo | <M><L><P><R><A><A><W><S><L><V><L><R><K><G><G><G><G><R><R><G><M><H><S><S><E><G><T><T><R><G><G><G><K><M><S><P><Y><T><N><C><Y><A><Q><R><Y><Y><P><M><P><E><E><P><F><C><T><E><L><N><A><E><E><Q><A><L><K><E><K><E><K><G><S><W><T><Q><L><T><H><A><E><K><V><A><L><Y><R><L><Q><F><N><E><T><F><A><E><M><N><R><R><S><N><E><W><K><T><V><M><G><C><V><F><F><F><I><G><F><A><A><L><V><I><W><W><Q><R><V><Y><V><F><P><P><K><P><I><T><L><T><D><E><R><K><A><Q><Q><L><Q><R><M><L><D><M><K><V><N><P><V><Q><G><L><A><S><R><W><D><Y><E><K><K><Q><W><K><K> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from | Q96KJ9 |
P55036 | PSMD4_HUMAN | Multiubiquitin chain-binding protein | Homo | <M><V><L><E><S><T><M><V><C><V><D><N><S><E><Y><M><R><N><G><D><F><L><P><T><R><L><Q><A><Q><Q><D><A><V><N><I><V><C><H><S><K><T><R><S><N><P><E><N><N><V><G><L><I><T><L><A><N><D><C><E><V><L><T><T><L><T><P><D><T><G><R><I><L><S><K><L><H><T><V><Q><P><K><G><K><I><T><F><C><T><G><I><R><V><A><H><L><A><L><K><H><R><Q><G><K><N><H><K><M><R><I><I><A><F><V><G><S><P><V><E><D><N><E><K><D><L><V><K><L><A><K><R><L><K><K><E><K><V><N><V><D><I><I><N><F><G><E><E><E><V><N><T><E><K><L><T><A><F><V><N><T><L><N><G><K><D><G><T><G><S><H><L><V><T><V><P><P><G><P><S><L><A><D><A><L><I><S><S><P><I><L><A><G><E><G><G><A><M><L><G><L><G><A><S><D><F><E><F><G><V><D><P><S><A><D><P><E><L><A><L><A><L><R><V><S><M><E><E><Q><R><Q><R><Q><E><E><E><A><R><R><A><A><A><A><S><A><A><E><A><G><I><A><T><T><G><T><E><D><S><D><D><A><L><L><K><M><T><I><S><Q><Q><E><F><G><R><T><G><L><P><D><L><S><S><M><T><E><E><E><Q><I><A><Y><A><M><Q><M><S><L><Q><G><A><E><F><G><Q><A><E><S><A><D><I><D><A><S><S><A><M><D><T><S><E><P><A><K><E><E><D><D><Y><D><V><M><Q><D><P><E><F><L><Q><S><V><L><E><N><L><P><G><V><D><P><N><N><E><A><I><R><N><A><M><G><S><L><A><S><Q><A><T><K><D><G><K><K><D><K><K><E><E><D><K><K> | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.<BOP> | P55036 |
Q12887 | COX10_HUMAN | Heme O synthase | Homo | <M><A><A><S><P><H><T><L><S><S><R><L><L><T><G><C><V><G><G><S><V><W><Y><L><E><R><R><T><I><Q><D><S><P><H><K><F><L><H><L><L><R><N><V><N><K><Q><W><I><T><F><Q><H><F><S><F><L><K><R><M><Y><V><T><Q><L><N><R><S><H><N><Q><Q><V><R><P><K><P><E><P><V><A><S><P><F><L><E><K><T><S><S><G><Q><A><K><A><E><I><Y><E><M><R><P><L><S><P><P><S><L><S><L><S><R><K><P><N><E><K><E><L><I><E><L><E><P><D><S><V><I><E><D><S><I><D><V><G><K><E><T><K><E><E><K><R><W><K><E><M><K><L><Q><V><Y><D><L><P><G><I><L><A><R><L><S><K><I><K><L><T><A><L><V><V><S><T><T><A><A><G><F><A><L><A><P><G><P><F><D><W><P><C><F><L><L><T><S><V><G><T><G><L><A><S><C><A><A><N><S><I><N><Q><F><F><E><V><P><F><D><S><N><M><N><R><T><K><N><R><P><L><V><R><G><Q><I><S><P><L><L><A><V><S><F><A><T><C><C><A><V><P><G><V><A><I><L><T><L><G><V><N><P><L><T><G><A><L><G><L><F><N><I><F><L><Y><T><C><C><Y><T><P><L><K><R><I><S><I><A><N><T><W><V><G><A><V><V><G><A><I><P><P><V><M><G><W><T><A><A><T><G><S><L><D><A><G><A><F><L><L><G><G><I><L><Y><S><W><Q><F><P><H><F><N><A><L><S><W><G><L><R><E><D><Y><S><R><G><G><Y><C><M><M><S><V><T><H><P><G><L><C><R><R><V><A><L><R><H><C><L><A><L><L><V><L><S><A><A><A><P><V><L><D><I><T><T><W><T><F><P><I><M><A><L><P><I><N><A><Y><I><S><Y><L><G><F><R><F><Y><V><D><A><D><R><R><S><S><R><R><L><F><F><C><S><L><W><H><L><P><L><L><L><L><L><M><L><T><C><K><R><P><S><G><G><G><D><A><G><P><P><P><S> | Converts protoheme IX and farnesyl diphosphate to heme O.<BOP> | Q12887 |
Q96T66 | NMNA3_HUMAN | Pyridine nucleotide adenylyltransferase 3 | Homo | <M><K><S><R><I><P><V><V><L><L><A><C><G><S><F><N><P><I><T><N><M><H><L><R><M><F><E><V><A><R><D><H><L><H><Q><T><G><M><Y><Q><V><I><Q><G><I><I><S><P><V><N><D><T><Y><G><K><K><D><L><A><A><S><H><H><R><V><A><M><A><R><L><A><L><Q><T><S><D><W><I><R><V><D><P><W><E><S><E><Q><A><Q><W><M><E><T><V><K><V><L><R><H><H><H><S><K><L><L><R><S><P><P><Q><M><E><G><P><D><H><G><K><A><L><F><S><T><P><A><A><V><P><E><L><K><L><L><C><G><A><D><V><L><K><T><F><Q><T><P><N><L><W><K><D><A><H><I><Q><E><I><V><E><K><F><G><L><V><C><V><G><R><V><G><H><D><P><K><G><Y><I><A><E><S><P><I><L><R><M><H><Q><H><N><I><H><L><A><K><E><P><V><Q><N><E><I><S><A><T><Y><I><R><R><A><L><G><Q><G><Q><S><V><K><Y><L><I><P><D><A><V><I><T><Y><I><K><D><H><G><L><Y><T><K><G><S><T><W><K><G><K><S><T><Q><S><T><E><G><K><T><S> | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.<BOP> | Q96T66 |
P35527 | K1C9_HUMAN | Keratin-9 | Homo | <M><S><C><R><Q><F><S><S><S><Y><L><S><R><S><G><G><G><G><G><G><G><L><G><S><G><G><S><I><R><S><S><Y><S><R><F><S><S><S><G><G><G><G><G><G><G><R><F><S><S><S><S><G><Y><G><G><G><S><S><R><V><C><G><R><G><G><G><G><S><F><G><Y><S><Y><G><G><G><S><G><G><G><F><S><A><S><S><L><G><G><G><F><G><G><G><S><R><G><F><G><G><A><S><G><G><G><Y><S><S><S><G><G><F><G><G><G><F><G><G><G><S><G><G><G><F><G><G><G><Y><G><S><G><F><G><G><F><G><G><F><G><G><G><A><G><G><G><D><G><G><I><L><T><A><N><E><K><S><T><M><Q><E><L><N><S><R><L><A><S><Y><L><D><K><V><Q><A><L><E><E><A><N><N><D><L><E><N><K><I><Q><D><W><Y><D><K><K><G><P><A><A><I><Q><K><N><Y><S><P><Y><Y><N><T><I><D><D><L><K><D><Q><I><V><D><L><T><V><G><N><N><K><T><L><L><D><I><D><N><T><R><M><T><L><D><D><F><R><I><K><F><E><M><E><Q><N><L><R><Q><G><V><D><A><D><I><N><G><L><R><Q><V><L><D><N><L><T><M><E><K><S><D><L><E><M><Q><Y><E><T><L><Q><E><E><L><M><A><L><K><K><N><H><K><E><E><M><S><Q><L><T><G><Q><N><S><G><D><V><N><V><E><I><N><V><A><P><G><K><D><L><T><K><T><L><N><D><M><R><Q><E><Y><E><Q><L><I><A><K><N><R><K><D><I><E><N><Q><Y><E><T><Q><I><T><Q><I><E><H><E><V><S><S><S><G><Q><E><V><Q><S><S><A><K><E><V><T><Q><L><R><H><G><V><Q><E><L><E><I><E><L><Q><S><Q><L><S><K><K><A><A><L><E><K><S><L><E><D><T><K><N><R><Y><C><G><Q><L><Q><M><I><Q><E><Q><I><S><N><L><E><A><Q><I><T><D><V><R><Q><E><I><E><C><Q><N><Q><E><Y><S><L><L><L><S><I><K><M><R><L><E><K><E><I><E><T><Y><H><N><L><L><E><G><G><Q><E><D><F><E><S><S><G><A><G><K><I><G><L><G><G><R><G><G><S><G><G><S><Y><G><R><G><S><R><G><G><S><G><G><S><Y><G><G><G><G><S><G><G><G><Y><G><G><G><S><G><S><R><G><G><S><G><G><S><Y><G><G><G><S><G><S><G><G><G><S><G><G><G><Y><G><G><G><S><G><G><G><H><S><G><G><S><G><G><G><H><S><G><G><S><G><G><N><Y><G><G><G><S><G><S><G><G><G><S><G><G><G><Y><G><G><G><S><G><S><R><G><G><S><G><G><S><H><G><G><G><S><G><F><G><G><E><S><G><G><S><Y><G><G><G><E><E><A><S><G><S><G><G><G><Y><G><G><G><S><G><K><S><S><H><S> | May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.<BOP> | P35527 |
Q8NEV9 | IL27A_HUMAN | p28 | Homo | <M><G><Q><T><A><G><D><L><G><W><R><L><S><L><L><L><L><P><L><L><L><V><Q><A><G><V><W><G><F><P><R><P><P><G><R><P><Q><L><S><L><Q><E><L><R><R><E><F><T><V><S><L><H><L><A><R><K><L><L><S><E><V><R><G><Q><A><H><R><F><A><E><S><H><L><P><G><V><N><L><Y><L><L><P><L><G><E><Q><L><P><D><V><S><L><T><F><Q><A><W><R><R><L><S><D><P><E><R><L><C><F><I><S><T><T><L><Q><P><F><H><A><L><L><G><G><L><G><T><Q><G><R><W><T><N><M><E><R><M><Q><L><W><A><M><R><L><D><L><R><D><L><Q><R><H><L><R><F><Q><V><L><A><A><G><F><N><L><P><E><E><E><E><E><E><E><E><E><E><E><E><E><R><K><G><L><L><P><G><A><L><G><S><A><L><Q><G><P><A><Q><V><S><W><P><Q><L><L><S><T><Y><R><L><L><H><S><L><E><L><V><L><S><R><A><V><R><E><L><L><L><L><S><K><A><G><H><S><V><W><P><L><G><F><P><T><L><S><P><Q><P> | Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1 | Q8NEV9 |
Q6NUK1 | SCMC1_HUMAN | Solute carrier family 25 member 24 | Homo | <M><L><R><W><L><R><D><F><V><L><P><T><A><A><C><Q><D><A><E><Q><P><T><R><Y><E><T><L><F><Q><A><L><D><R><N><G><D><G><V><V><D><I><G><E><L><Q><E><G><L><R><N><L><G><I><P><L><G><Q><D><A><E><E><K><I><F><T><T><G><D><V><N><K><D><G><K><L><D><F><E><E><F><M><K><Y><L><K><D><H><E><K><K><M><K><L><A><F><K><S><L><D><K><N><N><D><G><K><I><E><A><S><E><I><V><Q><S><L><Q><T><L><G><L><T><I><S><E><Q><Q><A><E><L><I><L><Q><S><I><D><V><D><G><T><M><T><V><D><W><N><E><W><R><D><Y><F><L><F><N><P><V><T><D><I><E><E><I><I><R><F><W><K><H><S><T><G><I><D><I><G><D><S><L><T><I><P><D><E><F><T><E><D><E><K><K><S><G><Q><W><W><R><Q><L><L><A><G><G><I><A><G><A><V><S><R><T><S><T><A><P><L><D><R><L><K><I><M><M><Q><V><H><G><S><K><S><D><K><M><N><I><F><G><G><F><R><Q><M><V><K><E><G><G><I><R><S><L><W><R><G><N><G><T><N><V><I><K><I><A><P><E><T><A><V><K><F><W><A><Y><E><Q><Y><K><K><L><L><T><E><E><G><Q><K><I><G><T><F><E><R><F><I><S><G><S><M><A><G><A><T><A><Q><T><F><I><Y><P><M><E><V><M><K><T><R><L><A><V><G><K><T><G><Q><Y><S><G><I><Y><D><C><A><K><K><I><L><K><H><E><G><L><G><A><F><Y><K><G><Y><V><P><N><L><L><G><I><I><P><Y><A><G><I><D><L><A><V><Y><E><L><L><K><S><Y><W><L><D><N><F><A><K><D><S><V><N><P><G><V><M><V><L><L><G><C><G><A><L><S><S><T><C><G><Q><L><A><S><Y><P><L><A><L><V><R><T><R><M><Q><A><Q><A><M><L><E><G><S><P><Q><L><N><M><V><G><L><F><R><R><I><I><S><K><E><G><I><P><G><L><Y><R><G><I><T><P><N><F><M><K><V><L><P><A><V><G><I><S><Y><V><V><Y><E><N><M><K><Q><T><L><G><V><T><Q><K> | Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.<BOP> | Q6NUK1 |
Q96LR9 | APLD1_HUMAN | Vascular early response gene protein | Homo | <M><F><R><A><P><C><H><R><L><R><A><R><G><T><R><K><A><R><A><G><A><W><R><G><C><T><F><P><C><L><G><K><G><M><E><R><P><A><A><R><E><P><H><G><P><D><A><L><R><R><F><Q><G><L><L><L><D><R><R><G><R><L><H><G><Q><V><L><R><L><R><E><V><A><R><R><L><E><R><L><R><R><R><S><L><V><A><N><V><A><G><S><S><L><S><A><T><G><A><L><A><A><I><V><G><L><S><L><S><P><V><T><L><G><T><S><L><L><V><S><A><V><G><L><G><V><A><T><A><G><G><A><V><T><I><T><S><D><L><S><L><I><F><C><N><S><R><E><L><R><R><V><Q><E><I><A><A><T><C><Q><D><Q><M><R><E><I><L><S><C><L><E><F><F><C><R><W><Q><G><C><G><D><R><Q><L><L><Q><C><G><R><N><A><S><I><A><L><Y><N><S><V><Y><F><I><V><F><F><G><S><R><G><F><L><I><P><R><R><A><E><G><D><T><K><V><S><Q><A><V><L><K><A><K><I><Q><K><L><A><E><S><L><E><S><C><T><G><A><L><D><E><L><S><E><Q><L><E><S><R><V><Q><L><C><T><K><S><S><R><G><H><D><L><K><I><S><A><D><Q><R><A><G><L><F><F> | May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.<BOP> | Q96LR9 |
O95936 | EOMES_HUMAN | T-box brain protein 2 | Homo | <M><Q><L><G><E><Q><L><L><V><S><S><V><N><L><P><G><A><H><F><Y><P><L><E><S><A><R><G><G><S><G><G><S><A><G><H><L><P><S><A><A><P><S><P><Q><K><L><D><L><D><K><A><S><K><K><F><S><G><S><L><S><C><E><A><V><S><G><E><P><A><A><A><S><A><G><A><P><A><A><M><L><S><D><T><D><A><G><D><A><F><A><S><A><A><A><V><A><K><P><G><P><P><D><G><R><K><G><S><P><C><G><E><E><E><L><P><S><A><A><A><A><A><A><A><A><A><A><A><A><A><A><T><A><R><Y><S><M><D><S><L><S><S><E><R><Y><Y><L><Q><S><P><G><P><Q><G><S><E><L><A><A><P><C><S><L><F><P><Y><Q><A><A><A><G><A><P><H><G><P><V><Y><P><A><P><N><G><A><R><Y><P><Y><G><S><M><L><P><P><G><G><F><P><A><A><V><C><P><P><G><R><A><Q><F><G><P><G><A><G><A><G><S><G><A><G><G><S><S><G><G><G><G><G><P><G><T><Y><Q><Y><S><Q><G><A><P><L><Y><G><P><Y><P><G><A><A><A><A><G><S><C><G><G><L><G><G><L><G><V><P><G><S><G><F><R><A><H><V><Y><L><C><N><R><P><L><W><L><K><F><H><R><H><Q><T><E><M><I><I><T><K><Q><G><R><R><M><F><P><F><L><S><F><N><I><N><G><L><N><P><T><A><H><Y><N><V><F><V><E><V><V><L><A><D><P><N><H><W><R><F><Q><G><G><K><W><V><T><C><G><K><A><D><N><N><M><Q><G><N><K><M><Y><V><H><P><E><S><P><N><T><G><S><H><W><M><R><Q><E><I><S><F><G><K><L><K><L><T><N><N><K><G><A><N><N><N><N><T><Q><M><I><V><L><Q><S><L><H><K><Y><Q><P><R><L><H><I><V><E><V><T><E><D><G><V><E><D><L><N><E><P><S><K><T><Q><T><F><T><F><S><E><T><Q><F><I><A><V><T><A><Y><Q><N><T><D><I><T><Q><L><K><I><D><H><N><P><F><A><K><G><F><R><D><N><Y><D><S><S><H><Q><I><V><P><G><G><R><Y><G><V><Q><S><F><F><P><E><P><F><V><N><T><L><P><Q><A><R><Y><Y><N><G><E><R><T><V><P><Q><T><N><G><L><L><S><P><Q><Q><S><E><E><V><A><N><P><P><Q><R><W><L><V><T><P><V><Q><Q><P><G><T><N><K><L><D><I><S><S><Y><E><S><E><Y><T><S><S><T><L><L><P><Y><G><I><K><S><L><P><L><Q><T><S><H><A><L><G><Y><Y><P><D><P><T><F><P><A><M><A><G><W><G><G><R><G><S><Y><Q><R><K><M><A><A><G><L><P><W><T><S><R><T><S><P><T><V><F><S><E><D><Q><L><S><K><E><K><V><K><E><E><I><G><S><S><W><I><E><T><P><P><S><I><K><S><L><D><S><N><D><S><G><V><Y><T><S><A><C><K><R><R><R><L><S><P><S><N><S><S><N><E><N><S><P><S><I><K><C><E><D><I><N><A><E><E><Y><S><K><D><T><S><K><G><M><G><G><Y><Y><A><F><Y><T><T><P> | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.<BOP> | O95936 |
P24530 | EDNRB_HUMAN | Endothelin receptor non-selective type | Homo | <M><Q><P><P><P><S><L><C><G><R><A><L><V><A><L><V><L><A><C><G><L><S><R><I><W><G><E><E><R><G><F><P><P><D><R><A><T><P><L><L><Q><T><A><E><I><M><T><P><P><T><K><T><L><W><P><K><G><S><N><A><S><L><A><R><S><L><A><P><A><E><V><P><K><G><D><R><T><A><G><S><P><P><R><T><I><S><P><P><P><C><Q><G><P><I><E><I><K><E><T><F><K><Y><I><N><T><V><V><S><C><L><V><F><V><L><G><I><I><G><N><S><T><L><L><R><I><I><Y><K><N><K><C><M><R><N><G><P><N><I><L><I><A><S><L><A><L><G><D><L><L><H><I><V><I><D><I><P><I><N><V><Y><K><L><L><A><E><D><W><P><F><G><A><E><M><C><K><L><V><P><F><I><Q><K><A><S><V><G><I><T><V><L><S><L><C><A><L><S><I><D><R><Y><R><A><V><A><S><W><S><R><I><K><G><I><G><V><P><K><W><T><A><V><E><I><V><L><I><W><V><V><S><V><V><L><A><V><P><E><A><I><G><F><D><I><I><T><M><D><Y><K><G><S><Y><L><R><I><C><L><L><H><P><V><Q><K><T><A><F><M><Q><F><Y><K><T><A><K><D><W><W><L><F><S><F><Y><F><C><L><P><L><A><I><T><A><F><F><Y><T><L><M><T><C><E><M><L><R><K><K><S><G><M><Q><I><A><L><N><D><H><L><K><Q><R><R><E><V><A><K><T><V><F><C><L><V><L><V><F><A><L><C><W><L><P><L><H><L><S><R><I><L><K><L><T><L><Y><N><Q><N><D><P><N><R><C><E><L><L><S><F><L><L><V><L><D><Y><I><G><I><N><M><A><S><L><N><S><C><I><N><P><I><A><L><Y><L><V><S><K><R><F><K><N><C><F><K><S><C><L><C><C><W><C><Q><S><F><E><E><K><Q><S><L><E><E><K><Q><S><C><L><K><F><K><A><N><D><H><G><Y><D><N><F><R><S><S><N><K><Y><S><S><S> | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<BOP> | P24530 |
A6NJG6 | ARGFX_HUMAN | Arginine-fifty homeobox | Homo | <M><R><N><R><M><A><P><E><N><P><Q><P><D><P><F><I><N><R><N><Y><S><N><M><K><V><I><P><P><Q><D><P><A><S><P><S><F><T><L><L><S><K><L><E><C><S><G><T><V><S><A><Y><C><S><L><N><L><P><G><S><T><D><P><P><T><S><A><S><R><V><A><A><T><T><A><I><R><R><R><H><K><E><R><T><S><F><T><H><Q><Q><Y><E><E><L><E><A><L><F><S><Q><T><M><F><P><D><R><N><L><Q><E><K><L><A><L><R><L><D><L><P><E><S><T><V><K><V><W><F><R><N><R><R><F><K><L><K><K><Q><Q><Q><Q><Q><S><A><K><Q><R><N><Q><I><L><P><S><K><K><N><V><P><T><S><P><R><T><S><P><S><P><Y><A><F><S><P><V><I><S><D><F><Y><S><S><L><P><S><Q><P><L><D><P><S><N><W><A><W><N><S><T><F><T><E><S><S><T><S><D><F><Q><M><Q><D><T><Q><W><E><R><L><V><A><S><V><P><A><L><Y><S><D><A><Y><D><I><F><Q><I><I><E><L><Y><N><L><P><D><E><N><E><I><S><S><S><S><F><H><C><L><Y><Q><Y><L><S><P><T><K><Y><Q><V><G><G><Q><G><S><S><L><S><I><F><A><G><P><A><V><G><L><S><P><A><Q><T><W><P><N><M><T><S><Q><A><F><E><A><Y><S><L><T><D><S><L><E><F><Q><K><T><S><N><M><V><D><L><G><F><L> | Transcription factor that acts as activator.<BOP> | A6NJG6 |
Q8NH90 | O5AK2_HUMAN | Olfactory receptor 5AK2 | Homo | <M><T><L><G><N><S><T><E><V><T><E><F><Y><L><L><G><F><G><A><Q><H><E><F><W><C><I><L><F><I><V><F><L><L><I><Y><V><T><S><I><M><G><N><S><G><I><I><L><L><I><N><T><D><S><R><F><Q><T><L><T><Y><F><F><L><Q><H><L><A><F><V><D><I><C><Y><T><S><A><I><T><P><K><M><L><Q><S><F><T><E><E><K><N><L><M><L><F><Q><G><C><V><I><Q><F><L><V><Y><A><T><F><A><T><S><D><C><Y><L><L><A><M><M><A><V><D><P><Y><V><A><I><C><K><P><L><H><Y><T><V><I><M><S><R><T><V><C><I><R><L><V><A><G><S><Y><I><M><G><S><I><N><A><S><V><Q><T><G><F><T><C><S><L><S><F><C><K><S><N><S><I><N><H><F><F><C><D><V><P><P><I><L><A><L><S><C><S><N><V><D><I><N><I><M><L><L><V><V><F><V><G><S><N><L><I><F><T><G><L><V><V><I><F><S><Y><I><Y><I><M><A><T><I><L><K><M><S><S><S><A><G><R><K><K><S><F><S><T><C><A><S><H><L><T><A><V><T><I><F><Y><G><T><L><S><Y><M><Y><L><Q><S><H><S><N><N><S><Q><E><N><M><K><V><A><F><I><F><Y><G><T><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><V><K><E><A><L><K><V><I><G><K><K><L><F> | Odorant receptor.<BOP> | Q8NH90 |
Q9BQA5 | HINFP_HUMAN | Methyl-CpG-binding protein 2-interacting zinc finger protein | Homo | <M><P><P><P><G><K><V><P><R><K><E><N><L><W><L><Q><C><E><W><G><S><C><S><F><V><C><S><T><M><E><K><F><F><E><H><V><T><Q><H><L><Q><Q><H><L><H><G><S><G><E><E><E><E><E><E><E><E><D><D><P><L><E><E><E><F><S><C><L><W><Q><E><C><G><F><C><S><L><D><S><S><A><D><L><I><R><H><V><Y><F><H><C><Y><H><T><K><L><K><Q><W><G><L><Q><A><L><Q><S><Q><A><D><L><G><P><C><I><L><D><F><Q><S><R><N><V><I><P><D><I><P><D><H><F><L><C><L><W><E><H><C><E><N><S><F><D><N><P><E><W><F><Y><R><H><V><E><A><H><S><L><C><C><E><Y><E><A><V><G><K><D><N><P><V><V><L><C><G><W><K><G><C><T><C><T><F><K><D><R><S><K><L><R><E><H><L><R><S><H><T><Q><E><K><V><V><A><C><P><T><C><G><G><M><F><A><N><N><T><K><F><L><D><H><I><R><R><Q><T><S><L><D><Q><Q><H><F><Q><C><S><H><C><S><K><R><F><A><T><E><R><L><L><R><D><H><M><R><N><H><V><N><H><Y><K><C><P><L><C><D><M><T><C><P><L><P><S><S><L><R><N><H><M><R><F><R><H><S><E><D><R><P><F><K><C><D><C><C><D><Y><S><C><K><N><L><I><D><L><Q><K><H><L><D><T><H><S><E><E><P><A><Y><R><C><D><F><E><N><C><T><F><S><A><R><S><L><C><S><I><K><S><H><Y><R><K><V><H><E><G><D><S><E><P><R><Y><K><C><H><V><C><D><K><C><F><T><R><G><N><N><L><T><V><H><L><R><K><K><H><Q><F><K><W><P><S><G><H><P><R><F><R><Y><K><E><H><E><D><G><Y><M><R><L><Q><L><V><R><Y><E><S><V><E><L><T><Q><Q><L><L><R><Q><P><Q><E><G><S><G><L><G><T><S><L><N><E><S><S><L><Q><G><I><I><L><E><T><V><P><G><E><P><G><R><K><E><E><E><E><E><G><K><G><S><E><G><T><A><L><S><A><S><Q><D><N><P><S><S><V><I><H><V><V><N><Q><T><N><A><Q><G><Q><Q><E><I><V><Y><Y><V><L><S><E><A><P><G><E><P><P><P><A><P><E><P><P><S><G><G><I><M><E><K><L><Q><G><I><A><E><E><P><E><I><Q><M><V> | Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.<BOP> | Q9BQA5 |
Q99941 | ATF6B_HUMAN | Processed cyclic AMP-dependent transcription factor ATF-6 beta | Homo | <M><A><E><L><M><L><L><S><E><I><A><D><P><T><R><F><F><T><D><N><L><L><S><P><E><D><W><G><L><Q><N><S><T><L><Y><S><G><L><D><E><V><A><E><E><Q><T><Q><L><F><R><C><P><E><Q><D><V><P><F><D><G><S><S><L><D><V><G><M><D><V><S><P><S><E><P><P><W><E><L><L><P><I><F><P><D><L><Q><V><K><S><E><P><S><S><P><C><S><S><S><S><L><S><S><E><S><S><R><L><S><T><E><P><S><S><E><A><L><G><V><G><E><V><L><H><V><K><T><E><S><L><A><P><P><L><C><L><L><G><D><D><P><T><S><S><F><E><T><V><Q><I><N><V><I><P><T><S><D><D><S><S><D><V><Q><T><K><I><E><P><V><S><P><C><S><S><V><N><S><E><A><S><L><L><S><A><D><S><S><S><Q><A><F><I><G><E><E><V><L><E><V><K><T><E><S><L><S><P><S><G><C><L><L><W><D><V><P><A><P><S><L><G><A><V><Q><I><S><M><G><P><S><L><D><G><S><S><G><K><A><L><P><T><R><K><P><P><L><Q><P><K><P><V><V><L><T><T><V><P><M><P><S><R><A><V><P><P><S><T><T><V><L><L><Q><S><L><V><Q><P><P><P><V><S><P><V><V><L><I><Q><G><A><I><R><V><Q><P><E><G><P><A><P><S><L><P><R><P><E><R><K><S><I><V><P><A><P><M><P><G><N><S><C><P><P><E><V><D><A><K><L><L><K><R><Q><Q><R><M><I><K><N><R><E><S><A><C><Q><S><R><R><K><K><K><E><Y><L><Q><G><L><E><A><R><L><Q><A><V><L><A><D><N><Q><Q><L><R><R><E><N><A><A><L><R><R><R><L><E><A><L><L><A><E><N><S><E><L><K><L><G><S><G><N><R><K><V><V><C><I><M><V><F><L><L><F><I><A><F><N><F><G><P><V><S><I><S><E><P><P><S><A><P><I><S><P><R><M><N><K><G><E><P><Q><P><R><R><H><L><L><G><F><S><E><Q><E><P><V><Q><G><V><E><P><L><Q><G><S><S><Q><G><P><K><E><P><Q><P><S><P><T><D><Q><P><S><F><S><N><L><T><A><F><P><G><G><A><K><E><L><L><L><R><D><L><D><Q><L><F><L><S><S><D><C><R><H><F><N><R><T><E><S><L><R><L><A><D><E><L><S><G><W><V><Q><R><H><Q><R><G><R><R><K><I><P><Q><R><A><Q><E><R><Q><K><S><Q><P><R><K><K><S><P><P><V><K><A><V><P><I><Q><P><P><G><P><P><E><R><D><S><V><G><Q><L><Q><L><Y><R><H><P><D><R><S><Q><P><A><F><L><D><A><I><D><R><R><E><D><T><F><Y><V><V><S><F><R><R><D><H><L><L><L><P><A><I><S><H><N><K><T><S><R><P><K><M><S><L><V><M><P><A><M><A><P><N><E><T><L><S><G><R><G><A><P><G><D><Y><E><E><M><M><Q><I><E><C><E><V><M><D><T><R><V><I><H><I><K><T><S><T><V><P><P><S><L><R><K><Q><P><S><P><T><P><G><N><A><T><G><G><P><L><P><V><S><A><A><S><Q><A><H><Q><A><S><H><Q><P><L><Y><L><N><H><P> | Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress . Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE .<BOP> | Q99941 |
Q99706 | KI2L4_HUMAN | MHC class I NK cell receptor KIR103AS | Homo | <M><S><M><S><P><T><V><I><I><L><A><C><L><G><F><F><L><D><Q><S><V><W><A><H><V><G><G><Q><D><K><P><F><C><S><A><W><P><S><A><V><V><P><Q><G><G><H><V><T><L><R><C><H><Y><R><R><G><F><N><I><F><T><L><Y><K><K><D><G><V><P><V><P><E><L><Y><N><R><I><F><W><N><S><F><L><I><S><P><V><T><P><A><H><A><G><T><Y><R><C><R><G><F><H><P><H><S><P><T><E><W><S><A><P><S><N><P><L><V><I><M><V><T><G><L><Y><E><K><P><S><L><T><A><R><P><G><P><T><V><R><A><G><E><N><V><T><L><S><C><S><S><Q><S><S><F><D><I><Y><H><L><S><R><E><G><E><A><H><E><L><R><L><P><A><V><P><S><I><N><G><T><F><Q><A><D><F><P><L><G><P><A><T><H><G><E><T><Y><R><C><F><G><S><F><H><G><S><P><Y><E><W><S><D><P><S><D><P><L><P><V><S><V><T><G><N><P><S><S><S><W><P><S><P><T><E><P><S><F><K><T><G><I><A><R><H><L><H><A><V><I><R><Y><S><V><A><I><I><L><F><T><I><L><P><F><F><L><L><H><R><W><C><S><K><K><K><D><A><A><V><M><N><Q><E><P><A><G><H><R><T><V><N><R><E><D><S><D><E><Q><D><P><Q><E><V><T><Y><A><Q><L><D><H><C><I><F><T><Q><R><K><I><T><G><P><S><Q><R><S><K><R><P><S><T><D><T><S><V><C><I><E><L><P><N><A><E><P><R><A><L><S><P><A><H><E><H><H><S><Q><A><L><M><G><S><S><R><E><T><T><A><L><S><Q><T><Q><L><A><S><S><N><V><P><A><A><G><I> | Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy . May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells . Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response .<BOP> | Q99706 |
Q9NYW8 | RBAK_HUMAN | Zinc finger protein 769 | Homo | <M><N><T><L><Q><G><P><V><S><F><K><D><V><A><V><D><F><T><Q><E><E><W><Q><Q><L><D><P><D><E><K><I><T><Y><R><D><V><M><L><E><N><Y><S><H><L><V><S><V><G><Y><D><T><T><K><P><N><V><I><I><K><L><E><Q><G><E><E><P><W><I><M><G><G><E><F><P><C><Q><H><S><P><E><A><W><R><V><D><D><L><I><E><R><I><Q><E><N><E><D><K><H><S><R><Q><A><A><C><I><N><S><K><T><L><T><E><E><K><E><N><T><F><S><Q><I><Y><M><E><T><S><L><V><P><S><S><I><I><A><H><N><C><V><S><C><G><K><N><L><E><S><I><S><Q><L><I><S><S><D><G><S><Y><A><R><T><K><P><D><E><C><N><E><C><G><K><T><Y><H><G><E><K><M><C><E><F><N><Q><N><G><D><T><Y><S><H><N><E><E><N><I><L><Q><K><I><S><I><L><E><K><P><F><E><Y><N><E><C><M><E><A><L><D><N><E><A><V><F><I><A><H><K><R><A><Y><I><G><E><K><P><Y><E><W><N><D><S><G><P><D><F><I><Q><M><S><N><F><N><A><Y><Q><R><S><Q><M><E><M><K><P><F><E><C><S><E><C><G><K><S><F><C><K><K><S><K><F><I><I><H><Q><R><A><H><T><G><E><K><P><Y><E><C><N><V><C><G><K><S><F><S><Q><K><G><T><L><T><V><H><R><R><S><H><L><E><E><K><P><Y><K><C><N><E><C><G><K><T><F><C><Q><K><L><H><L><T><Q><H><L><R><T><H><S><G><E><K><P><Y><E><C><S><E><C><G><K><T><F><C><Q><K><T><H><L><T><L><H><Q><R><N><H><S><G><E><R><P><Y><P><C><N><E><C><G><K><S><F><S><R><K><S><A><L><S><D><H><Q><R><T><H><T><G><E><K><L><Y><K><C><N><E><C><G><K><S><Y><Y><R><K><S><T><L><I><T><H><Q><R><T><H><T><G><E><K><P><Y><Q><C><S><E><C><G><K><F><F><S><R><V><S><Y><L><T><I><H><Y><R><S><H><L><E><E><K><P><Y><E><C><N><E><C><G><K><T><F><N><L><N><S><A><F><I><R><H><R><K><V><H><T><E><E><K><S><H><E><C><S><E><C><G><K><F><S><Q><L><Y><L><T><D><H><H><T><A><H><L><E><E><K><P><Y><E><C><N><E><C><G><K><T><F><L><V><N><S><A><F><D><G><H><Q><P><L><P><K><G><E><K><S><Y><E><C><N><V><C><G><K><L><F><N><E><L><S><Y><Y><T><E><H><Y><R><S><H><S><E><E><K><P><Y><G><C><S><E><C><G><K><T><F><S><H><N><S><S><L><F><R><H><Q><R><V><H><T><G><E><K><P><Y><E><C><Y><E><C><G><K><F><F><S><Q><K><S><Y><L><T><I><H><H><R><I><H><S><G><E><K><P><Y><E><C><S><K><C><G><K><V><F><S><R><M><S><N><L><T><V><H><Y><R><S><H><S><G><E><K><P><Y><E><C><N><E><C><G><K><V><F><S><Q><K><S><Y><L><T><V><H><Y><R><T><H><S><G><E><K><P><Y><E><C><N><E><C><G><K><K><F><H><H><R><S><A><F><N><S><H><Q><R><I><H><R><R><G><N><M><N><V><L><D><V><E><N><L> | May repress E2F-dependent transcription. May promote AR-dependent transcription.<BOP> | Q9NYW8 |
K9M1U5 | IFNL4_HUMAN | Interferon lambda-4 | Homo | <M><R><P><S><V><W><A><A><V><A><A><G><L><W><V><L><C><T><V><I><A><A><A><P><R><R><C><L><L><S><H><Y><R><S><L><E><P><R><T><L><A><A><A><K><A><L><R><D><R><Y><E><E><E><A><L><S><W><G><Q><R><N><C><S><F><R><P><R><R><D><P><P><R><P><S><S><C><A><R><L><R><H><V><A><R><G><I><A><D><A><Q><A><V><L><S><G><L><H><R><S><E><L><L><P><G><A><G><P><I><L><E><L><L><A><A><A><G><R><D><V><A><A><C><L><E><L><A><R><P><G><S><S><R><K><V><P><G><A><Q><K><R><R><H><K><P><R><R><A><D><S><P><R><C><R><K><A><S><V><V><F><N><L><L><R><L><L><T><W><E><L><R><L><A><A><H><S><G><P><C><L> | Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes.<BOP> | K9M1U5 |
P05108 | CP11A_HUMAN | Cytochrome P450(scc) | Homo | <M><L><A><K><G><L><P><P><R><S><V><L><V><K><G><C><Q><T><F><L><S><A><P><R><E><G><L><G><R><L><R><V><P><T><G><E><G><A><G><I><S><T><R><S><P><R><P><F><N><E><I><P><S><P><G><D><N><G><W><L><N><L><Y><H><F><W><R><E><T><G><T><H><K><V><H><L><H><H><V><Q><N><F><Q><K><Y><G><P><I><Y><R><E><K><L><G><N><V><E><S><V><Y><V><I><D><P><E><D><V><A><L><L><F><K><S><E><G><P><N><P><E><R><F><L><I><P><P><W><V><A><Y><H><Q><Y><Y><Q><R><P><I><G><V><L><L><K><K><S><A><A><W><K><K><D><R><V><A><L><N><Q><E><V><M><A><P><E><A><T><K><N><F><L><P><L><L><D><A><V><S><R><D><F><V><S><V><L><H><R><R><I><K><K><A><G><S><G><N><Y><S><G><D><I><S><D><D><L><F><R><F><A><F><E><S><I><T><N><V><I><F><G><E><R><Q><G><M><L><E><E><V><V><N><P><E><A><Q><R><F><I><D><A><I><Y><Q><M><F><H><T><S><V><P><M><L><N><L><P><P><D><L><F><R><L><F><R><T><K><T><W><K><D><H><V><A><A><W><D><V><I><F><S><K><A><D><I><Y><T><Q><N><F><Y><W><E><L><R><Q><K><G><S><V><H><H><D><Y><R><G><I><L><Y><R><L><L><G><D><S><K><M><S><F><E><D><I><K><A><N><V><T><E><M><L><A><G><G><V><D><T><T><S><M><T><L><Q><W><H><L><Y><E><M><A><R><N><L><K><V><Q><D><M><L><R><A><E><V><L><A><A><R><H><Q><A><Q><G><D><M><A><T><M><L><Q><L><V><P><L><L><K><A><S><I><K><E><T><L><R><L><H><P><I><S><V><T><L><Q><R><Y><L><V><N><D><L><V><L><R><D><Y><M><I><P><A><K><T><L><V><Q><V><A><I><Y><A><L><G><R><E><P><T><F><F><F><D><P><E><N><F><D><P><T><R><W><L><S><K><D><K><N><I><T><Y><F><R><N><L><G><F><G><W><G><V><R><Q><C><L><G><R><R><I><A><E><L><E><M><T><I><F><L><I><N><M><L><E><N><F><R><V><E><I><Q><H><L><S><D><V><G><T><T><F><N><L><I><L><M><P><E><K><P><I><S><F><T><F><W><P><F><N><Q><E><A><T><Q><Q> | A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones . Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) .<BOP> | P05108 |
Q8N4W6 | DJC22_HUMAN | DnaJ homolog subfamily C member 22 | Homo | <M><A><K><G><L><L><V><T><Y><A><L><W><A><V><G><G><P><A><G><L><H><H><L><Y><L><G><R><D><S><H><A><L><L><W><M><L><T><L><G><G><G><G><L><G><W><L><W><E><F><W><K><L><P><S><F><V><A><Q><A><N><R><A><Q><G><Q><R><Q><S><P><R><G><V><T><P><P><L><S><P><I><R><F><A><A><Q><V><I><V><G><I><Y><F><G><L><V><A><L><I><S><L><S><S><M><V><N><F><Y><I><V><A><L><P><L><A><V><G><L><G><V><L><L><V><A><A><V><G><N><Q><T><S><D><F><K><N><T><L><G><S><A><F><L><T><S><P><I><F><Y><G><R><P><I><A><I><L><P><I><S><V><A><A><S><I><T><A><Q><R><H><R><R><Y><K><A><L><V><A><S><E><P><L><S><V><R><L><Y><R><L><G><L><A><Y><L><A><F><T><G><P><L><A><Y><S><A><L><C><N><T><A><A><T><L><S><Y><V><A><E><T><F><G><S><F><L><N><W><F><S><F><F><P><L><L><G><R><L><M><E><F><V><L><L><L><P><Y><R><I><W><R><L><L><M><G><E><T><G><F><N><S><S><C><F><Q><E><W><A><K><L><Y><E><F><V><H><S><F><Q><D><E><K><R><Q><L><A><Y><Q><V><L><G><L><S><E><G><A><T><N><E><E><I><H><R><S><Y><Q><E><L><V><K><V><W><H><P><D><H><N><L><D><Q><T><E><E><A><Q><R><H><F><L><E><I><Q><A><A><Y><E><V><L><S><Q><P><R><K><P><W><G><S><R><R> | May function as a co-chaperone.<BOP> | Q8N4W6 |
A0A0A6YYK1 | TVA81_HUMAN | T cell receptor alpha variable 8-1 | Homo | <M><L><L><L><L><I><P><V><L><G><M><I><F><A><L><R><D><A><R><A><Q><S><V><S><Q><H><N><H><H><V><I><L><S><E><A><A><S><L><E><L><G><C><N><Y><S><Y><G><G><T><V><N><L><F><W><Y><V><Q><Y><P><G><Q><H><L><Q><L><L><L><K><Y><F><S><G><D><P><L><V><K><G><I><K><G><F><E><A><E><F><I><K><S><K><F><S><F><N><L><R><K><P><S><V><Q><W><S><D><T><A><E><Y><F><C><A><V><N> | V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0A6YYK1 |
Q7L8L6 | FAKD5_HUMAN | FAST kinase domain-containing protein 5, mitochondrial | Homo | <M><A><A><T><L><K><S><L><K><L><V><R><Y><R><A><F><C><S><P><S><A><F><G><A><V><R><S><V><S><Y><W><N><V><S><S><T><Q><H><G><G><Q><D><P><P><E><H><I><S><L><C><H><S><A><K><K><V><K><N><I><C><S><T><F><S><S><R><R><I><L><T><T><S><S><A><H><P><G><L><E><F><S><K><T><S><S><S><K><A><S><T><L><Q><L><G><S><P><R><A><T><G><V><D><E><E><D><V><E><V><F><D><S><F><E><N><M><R><V><F><L><Q><L><R><P><E><Y><R><V><H><S><Y><N><A><S><E><T><S><Q><L><L><S><V><S><E><G><E><L><I><L><H><K><V><R><V><N><Q><N><N><L><Q><A><Q><V><I><V><D><Y><L><C><K><L><S><S><L><P><A><E><Q><H><P><V><L><L><G><S><T><S><F><A><L><L><C><Q><L><S><V><K><K><I><Q><L><F><D><T><Q><D><L><I><N><V><L><K><A><F><V><I><L><G><I><P><H><S><H><S><M><L><D><V><Y><E><T><K><C><C><H><Q><V><W><E><M><N><M><D><Q><L><L><L><V><A><D><L><W><R><Y><L><G><R><K><V><P><R><F><L><N><I><F><S><S><Y><L><N><L><H><W><K><D><L><S><L><S><Q><L><V><H><L><I><Y><V><I><G><E><N><R><Q><V><S><Q><D><L><M><Q><K><L><E><S><L><I><L><K><Y><I><D><L><I><N><L><E><E><V><G><T><I><C><L><G><F><F><K><S><S><T><N><L><S><E><F><V><M><R><K><I><G><D><L><A><C><A><N><I><Q><H><L><S><S><R><S><L><V><N><I><V><K><M><F><R><F><T><H><V><D><H><I><N><F><M><K><Q><I><G><E><I><A><P><Q><R><I><P><S><L><G><V><Q><G><V><M><H><L><T><L><Y><C><S><A><L><R><F><L><N><E><G><V><M><N><A><V><A><A><S><L><P><P><R><V><A><H><C><R><S><K><D><V><A><K><I><L><W><S><F><G><T><L><N><Y><K><P><P><N><A><E><E><F><Y><S><S><L><I><S><E><I><H><R><K><M><P><E><F><N><Q><Y><P><E><H><L><P><T><C><L><L><G><L><A><F><L><E><Y><F><P><V><E><L><I><D><F><A><L><S><P><G><F><V><R><L><A><Q><E><R><T><K><F><D><L><L><K><E><L><Y><T><L><D><G><T><V><G><I><E><C><P><D><Y><R><G><N><R><L><S><T><H><L><Q><Q><E><G><S><E><L><L><W><Y><L><A><E><K><D><M><N><S><K><P><E><F><L><E><T><V><F><L><L><E><T><M><L><G><G><P><Q><Y><V><K><H><H><M><I><L><P><H><T><R><S><S><D><L><E><V><Q><L><D><V><N><L><K><P><L><P><F><N><R><E><A><T><P><A><E><N><V><A><K><L><R><L><E><H><V><G><V><S><L><T><D><D><L><M><N><K><L><L><K><G><K><A><R><G><H><F><Q><G><K><T><E><S><E><P><G><Q><Q><P><M><E><L><E><N><K><A><A><V><P><L><G><G><F><L><C><N><V><A><D><K><S><G><A><M><E><M><A><G><L><C><P><A><A><C><M><Q><T><P><R><M><K><L><A><V><Q><F><T><N><R><N><Q><Y><C><Y><G><S><R><D><L><L><G><L><H><N><M><K><R><R><Q><L><A><R><L><G><Y><R><V><V><E><L><S><Y><W><E><W><L><P><L><L><K><R><T><R><L><E><K><L><A><F><L><H><E><K><V><F><T><S><A><L> | Plays an important role in the processing of non-canonical mitochondrial mRNA precursors .<BOP> | Q7L8L6 |
P60410 | KR108_HUMAN | Keratin-associated protein 18.8 | Homo | <M><A><D><A><C><C><T><R><T><Y><V><I><A><A><S><T><M><S><V><C><S><S><D><V><G><H><V><S><R><V><S><S><P><S><T><C><T><G><S><S><W><Q><V><D><N><C><Q><E><S><C><C><E><P><R><S><C><A><S><S><C><C><T><P><S><C><C><A><P><A><P><C><L><A><L><V><C><A><P><V><S><C><E><P><S><P><C><Q><S><G><C><T><D><S><C><T><P><S><C><C><Q><Q><S><S><C><Q><P><A><C><C><T><S><S><P><C><Q><Q><A><C><C><V><P><V><C><C><K><S><N><C><C><K><P><V><C><C><V><S><I><C><S><G><A><S><S><P><C><C><Q><Q><S><S><C><Q><S><A><C><C><T><F><S><P><C><Q><Q><A><C><C><V><P><I><C><C><K><P><I><C><C><V><P><V><C><S><G><A><S><S><L><C><C><Q><K><S><S><C><Q><P><A><C><C><T><T><S><C><C><R><P><S><S><S><V><S><L><L><C><R><P><V><C><R><P><A><C><C><V><P><V><P><S><C><C><V><P><A><S><S><C><Q><P><S><C><C><H><P><A><S><C><L><S><F><L><C><R><P><A><C><S><R><L><A><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | P60410 |
P13584 | CP4B1_HUMAN | Cytochrome P450-HP | Homo | <M><V><P><S><F><L><S><L><S><F><S><S><L><G><L><W><A><S><G><L><I><L><V><L><G><F><L><K><L><I><H><L><L><L><R><R><Q><T><L><A><K><A><M><D><K><F><P><G><P><P><T><H><W><L><F><G><H><A><L><E><I><Q><E><T><G><S><L><D><K><V><V><S><W><A><H><Q><F><P><Y><A><H><P><L><W><F><G><Q><F><I><G><F><L><N><I><Y><E><P><D><Y><A><K><A><V><Y><S><R><G><D><P><K><A><P><D><V><Y><D><F><F><L><Q><W><I><G><R><G><L><L><V><L><E><G><P><K><W><L><Q><H><R><K><L><L><T><P><G><F><H><Y><D><V><L><K><P><Y><V><A><V><F><T><E><S><T><R><I><M><L><D><K><W><E><E><K><A><R><E><G><K><S><F><D><I><F><C><D><V><G><H><M><A><L><N><T><L><M><K><C><T><F><G><R><G><D><T><G><L><G><H><R><D><S><S><Y><Y><L><A><V><S><D><L><T><L><L><M><Q><Q><R><L><V><S><F><Q><Y><H><N><D><F><I><Y><W><L><T><P><H><G><R><R><F><L><R><A><C><Q><V><A><H><D><H><T><D><Q><V><I><R><E><R><K><A><A><L><Q><D><E><K><V><R><K><K><I><Q><N><R><R><H><L><D><F><L><D><I><L><L><G><A><R><D><E><D><D><I><K><L><S><D><A><D><L><R><A><E><V><D><T><F><M><F><E><G><H><D><T><T><T><S><G><I><S><W><F><L><Y><C><M><A><L><Y><P><E><H><Q><H><R><C><R><E><E><V><R><E><I><L><G><D><Q><D><F><F><Q><W><D><D><L><G><K><M><T><Y><L><T><M><C><I><K><E><S><F><R><L><Y><P><P><V><P><Q><V><Y><R><Q><L><S><K><P><V><T><F><V><D><G><R><S><L><P><A><G><S><L><I><S><M><H><I><Y><A><L><H><R><N><S><A><V><W><P><D><P><E><V><F><D><S><L><R><F><S><T><E><N><A><S><K><R><H><P><F><A><F><M><P><F><S><A><G><P><R><N><C><I><G><Q><Q><F><A><M><S><E><M><K><V><V><T><A><M><C><L><L><R><F><E><F><S><L><D><P><S><R><L><P><I><K><M><P><Q><L><V><L><R><S><K><N><G><F><H><L><H><L><K><P><L><G><P><G><S><G><K> | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.<BOP> | P13584 |
Q8WZ92 | OR5P2_HUMAN | Olfactory receptor-like protein JCG3 | Homo | <M><N><S><L><K><D><G><N><H><T><A><L><T><G><F><I><L><L><G><L><T><D><D><P><I><L><R><V><I><L><F><M><I><I><L><S><G><N><L><S><I><I><I><L><I><R><I><S><S><Q><L><H><H><P><M><Y><F><F><L><S><H><L><A><F><A><D><M><A><Y><S><S><S><V><T><P><N><M><L><V><N><F><L><V><E><R><N><T><V><S><Y><L><G><C><A><I><Q><L><G><S><A><A><F><F><A><T><V><E><C><V><L><L><A><A><M><A><Y><D><R><F><V><A><I><C><S><P><L><L><Y><S><T><K><M><S><T><Q><V><S><V><Q><L><L><L><V><V><Y><I><A><G><F><L><I><A><V><S><Y><T><T><S><F><Y><F><L><L><F><C><G><P><N><Q><V><N><H><F><F><C><D><F><A><P><L><L><E><L><S><C><S><D><I><S><V><S><T><V><V><L><S><F><S><S><G><S><I><I><V><V><T><V><C><V><I><A><V><C><Y><I><Y><I><L><I><T><I><L><K><M><R><S><T><E><G><H><H><K><A><F><S><T><C><T><S><H><L><T><V><V><T><L><F><Y><G><T><I><T><F><I><Y><V><M><P><N><F><S><Y><S><T><D><Q><N><K><V><V><S><V><L><Y><T><V><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><E><I><K><G><A><L><K><R><E><L><V><R><K><I><L><S><H><D><A><C><Y><F><S><R><T><S><N><N><D><I><T> | Odorant receptor (Potential). May be involved in taste perception.<BOP> | Q8WZ92 |
P12724 | ECP_HUMAN | Ribonuclease 3 | Homo | <M><V><P><K><L><F><T><S><Q><I><C><L><L><L><L><L><G><L><M><G><V><E><G><S><L><H><A><R><P><P><Q><F><T><R><A><Q><W><F><A><I><Q><H><I><S><L><N><P><P><R><C><T><I><A><M><R><A><I><N><N><Y><R><W><R><C><K><N><Q><N><T><F><L><R><T><T><F><A><N><V><V><N><V><C><G><N><Q><S><I><R><C><P><H><N><R><T><L><N><N><C><H><R><S><R><F><R><V><P><L><L><H><C><D><L><I><N><P><G><A><Q><N><I><S><N><C><T><Y><A><D><R><P><G><R><R><F><Y><V><V><A><C><D><N><R><D><P><R><D><S><P><R><Y><P><V><V><P><V><H><L><D><T><T><I> | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<BOP> | P12724 |
Q02318 | CP27A_HUMAN | Vitamin D(3) 25-hydroxylase | Homo | <M><A><A><L><G><C><A><R><L><R><W><A><L><R><G><A><G><R><G><L><C><P><H><G><A><R><A><K><A><A><I><P><A><A><L><P><S><D><K><A><T><G><A><P><G><A><G><P><G><V><R><R><R><Q><R><S><L><E><E><I><P><R><L><G><Q><L><R><F><F><F><Q><L><F><V><Q><G><Y><A><L><Q><L><H><Q><L><Q><V><L><Y><K><A><K><Y><G><P><M><W><M><S><Y><L><G><P><Q><M><H><V><N><L><A><S><A><P><L><L><E><Q><V><M><R><Q><E><G><K><Y><P><V><R><N><D><M><E><L><W><K><E><H><R><D><Q><H><D><L><T><Y><G><P><F><T><T><E><G><H><H><W><Y><Q><L><R><Q><A><L><N><Q><R><L><L><K><P><A><E><A><A><L><Y><T><D><A><F><N><E><V><I><D><D><F><M><T><R><L><D><Q><L><R><A><E><S><A><S><G><N><Q><V><S><D><M><A><Q><L><F><Y><Y><F><A><L><E><A><I><C><Y><I><L><F><E><K><R><I><G><C><L><Q><R><S><I><P><E><D><T><V><T><F><V><R><S><I><G><L><M><F><Q><N><S><L><Y><A><T><F><L><P><K><W><T><R><P><V><L><P><F><W><K><R><Y><L><D><G><W><N><A><I><F><S><F><G><K><K><L><I><D><E><K><L><E><D><M><E><A><Q><L><Q><A><A><G><P><D><G><I><Q><V><S><G><Y><L><H><F><L><L><A><S><G><Q><L><S><P><R><E><A><M><G><S><L><P><E><L><L><M><A><G><V><D><T><T><S><N><T><L><T><W><A><L><Y><H><L><S><K><D><P><E><I><Q><E><A><L><H><E><E><V><V><G><V><V><P><A><G><Q><V><P><Q><H><K><D><F><A><H><M><P><L><L><K><A><V><L><K><E><T><L><R><L><Y><P><V><V><P><T><N><S><R><I><I><E><K><E><I><E><V><D><G><F><L><F><P><K><N><T><Q><F><V><F><C><H><Y><V><V><S><R><D><P><T><A><F><S><E><P><E><S><F><Q><P><H><R><W><L><R><N><S><Q><P><A><T><P><R><I><Q><H><P><F><G><S><V><P><F><G><Y><G><V><R><A><C><L><G><R><R><I><A><E><L><E><M><Q><L><L><L><A><R><L><I><Q><K><Y><K><V><V><L><A><P><E><T><G><E><L><K><S><V><A><R><I><V><L><V><P><N><K><K><V><G><L><Q><F><L><Q><R><Q><C> | Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid . Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways . May also regulate cholesterol homeostasis via generation of active oxysterols, which act as ligands for NR1H2 and NR1H3 nuclear receptors, modulating the transcription of genes involved in lipid metabolism . Plays a role in cholestanol metabolism in the cerebellum. Similarly to cholesterol, hydroxylates cholestanol and may facilitate sterol diffusion through the blood-brain barrier to the systemic circulation for further degradation . Also hydroxylates retinal 7-ketocholesterol, a noxious oxysterol with pro-inflammatory and pro-apoptotic effects, and may play a role in its elimination from the retinal pigment epithelium . May | Q02318 |
Q13938 | CAYP1_HUMAN | Calcyphosine | Homo | <M><Q><C><H><R><D><L><A><L><S><Q><A><L><W><G><W><Q><L><S><K><Q><S><G><W><A><H><P><S><L><P><H><S><P><L><P><S><T><V><H><S><C><S><W><A><P><P><H><L><Q><R><H><L><P><L><A><T><V><S><P><G><T><T><Q><L><T><Q><G><P><A><G><R><T><L><G><Q><T><Q><A><S><C><P><E><P><R><P><S><M><D><A><V><D><A><T><M><E><K><L><R><A><Q><C><L><S><R><G><A><S><G><I><Q><G><L><A><R><F><F><R><Q><L><D><R><D><G><S><R><S><L><D><A><D><E><F><R><Q><G><L><A><K><L><G><L><V><L><D><Q><A><E><A><E><G><V><C><R><K><W><D><R><N><G><S><G><T><L><D><L><E><E><F><L><R><A><L><R><P><P><M><S><Q><A><R><E><A><V><I><A><A><A><F><A><K><L><D><R><S><G><D><G><V><V><T><V><D><D><L><R><G><V><Y><S><G><R><A><H><P><K><V><R><S><G><E><W><T><E><D><E><V><L><R><R><F><L><D><N><F><D><S><S><E><K><D><G><Q><V><T><L><A><E><F><Q><D><Y><Y><S><G><V><S><A><S><M><N><T><D><E><E><F><V><A><M><M><T><S><A><W><Q><L> | Calcium-binding protein. May play a role in cellular signaling events (Potential).<BOP> | Q13938 |
Q9H9L3 | I20L2_HUMAN | Interferon-stimulated 20 kDa exonuclease-like 2 | Homo | <M><S><T><L><L><L><N><L><D><F><G><E><P><P><P><K><K><A><L><E><G><N><A><K><H><R><N><F><V><K><K><R><R><L><L><E><R><R><G><F><L><S><K><K><N><Q><P><P><S><K><A><P><K><L><H><S><E><P><S><K><K><G><E><T><P><T><V><D><G><T><W><K><T><P><S><F><P><K><K><K><T><A><A><S><S><N><G><S><G><Q><P><L><D><K><K><A><A><V><S><W><L><T><P><A><P><S><K><K><A><D><S><V><A><A><K><V><D><L><L><G><E><F><Q><S><A><L><P><K><I><N><S><H><P><T><R><S><Q><K><K><S><S><Q><K><K><S><S><K><K><N><H><P><Q><K><N><A><P><Q><N><S><T><Q><A><H><S><E><N><K><C><S><G><A><S><Q><K><L><P><R><K><M><V><A><I><D><C><E><M><V><G><T><G><P><K><G><H><V><S><S><L><A><R><C><S><I><V><N><Y><N><G><D><V><L><Y><D><E><Y><I><L><P><P><C><H><I><V><D><Y><R><T><R><W><S><G><I><R><K><Q><H><M><V><N><A><T><P><F><K><I><A><R><G><Q><I><L><K><I><L><T><G><K><I><V><V><G><H><A><I><H><N><D><F><K><A><L><Q><Y><F><H><P><K><S><L><T><R><D><T><S><H><I><P><P><L><N><R><K><A><D><C><P><E><N><A><T><M><S><L><K><H><L><T><K><K><L><L><N><R><D><I><Q><V><G><K><S><G><H><S><S><V><E><D><A><Q><A><T><M><E><L><Y><K><L><V><E><V><E><W><E><E><H><L><A><R><N><P><P><T><D> | 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group.<BOP> | Q9H9L3 |
B1APH4 | ZN487_HUMAN | KRAB domain only protein 1 | Homo | <M><A><S><R><P><R><P><R><T><P><S><R><G><P><S><D><L><R><F><R><G><E><A><G><L><R><R><V><F><L><K><K><A><G><G><S><V><S><F><S><D><V><A><V><G><F><T><Q><E><E><W><Q><H><L><D><S><A><Q><R><T><P><Y><R><D><M><M><L><E><N><Y><S><L><L><L><S><V><G><Y><C><I><T><K><P><E><V><V><C><K><L><E><H><G><Q><V><L><W><I><L><E><E><E><S><P><S><Q><S><H><L><D><C><C><I><D><D><D><L><M><E><K><R><Q><E><N><Q><D><Q><H><L><Q><K><V><D><F><V><N><N><K><T><L><T><M><D><R><N><G><V><L><G><K><T><F><S><L><D><T><N><P><I><L><S><R><K><I><R><G><N><C><D><S><S><G><M><N><L><N><N><I><S><E><L><I><I><S><N><R><S><S><F><V><R><N><P><A><E><C><N><V><R><G><K><F><L><L><C><M><K><R><E><N><P><Y><A><R><G><K><P><L><E><Y><D><G><N><G><K><A><V><S><Q><N><E><D><L><F><R><H><Q><Y><I><Q><T><L><K><Q><C><F><E><Y><N><H><R><G><Y><T><E><E><R><N><P><M><N><A><L><N><V><G><K><L><L><D><I><G><H><A><L><Q><Y><I><K><E><H><T><R><D><K><T><Y><E><C><N><E><C><G><K><N><F><C><E><K><S><N><L><H><V><H><Q><R><T><H><T><G><E><K><P><Y><G><C><N><E><C><Q><K><A><F><G><D><R><S><A><L><K><V><H><Q><R><I><H><T><G><E><K><P><Y><E><L><H><Q><R><T><H><T><G><E><K><P><Y><A><C><S><E><C><G><K><T><F><Y><Q><K><S><S><L><T><T><H><Q><R><T><H><T><R><E><Q><P><Y><E><Y><N><E><S><F><Y><Q><N><P><N><F><T><K><C><Q><R><D><N><I><E><E><T><L><V><N><I><L><K><A><Q><K><P><S><P><S><W><T><R><S><I><A><E><T><T><Q><V><G><G><S><V><S><L><K><D><V><T><V><D><F><T><Q><E><E><W> | May be involved in transcriptional regulation.<BOP> | B1APH4 |
Q00059 | TFAM_HUMAN | Transcription factor 6-like 2 | Homo | <M><A><F><L><R><S><M><W><G><V><L><S><A><L><G><R><S><G><A><E><L><C><T><G><C><G><S><R><L><R><S><P><F><S><F><V><Y><L><P><R><W><F><S><S><V><L><A><S><C><P><K><K><P><V><S><S><Y><L><R><F><S><K><E><Q><L><P><I><F><K><A><Q><N><P><D><A><K><T><T><E><L><I><R><R><I><A><Q><R><W><R><E><L><P><D><S><K><K><K><I><Y><Q><D><A><Y><R><A><E><W><Q><V><Y><K><E><E><I><S><R><F><K><E><Q><L><T><P><S><Q><I><M><S><L><E><K><E><I><M><D><K><H><L><K><R><K><A><M><T><K><K><K><E><L><T><L><L><G><K><P><K><R><P><R><S><A><Y><N><V><Y><V><A><E><R><F><Q><E><A><K><G><D><S><P><Q><E><K><L><K><T><V><K><E><N><W><K><N><L><S><D><S><E><K><E><L><Y><I><Q><H><A><K><E><D><E><T><R><Y><H><N><E><M><K><S><W><E><E><Q><M><I><E><V><G><R><K><D><L><L><R><R><T><I><K><K><Q><R><K><Y><G><A><E><E><C> | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation . Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA . In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand . Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase . Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites . Is able to unwind DNA . Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes . Required for maintenance of normal levels of mitochondrial DNA . May play a role in organizing and compacting mitochondrial DNA .<BOP> | Q00059 |
O60256 | KPRB_HUMAN | 41 kDa phosphoribosypyrophosphate synthetase-associated protein | Homo | <M><F><C><V><T><P><P><E><L><E><T><K><M><N><I><T><K><G><G><L><V><L><F><S><A><N><S><N><S><S><C><M><E><L><S><K><K><I><A><E><R><L><G><V><E><M><G><K><V><Q><V><Y><Q><E><P><N><R><E><T><R><V><Q><I><Q><E><S><V><R><G><K><D><V><F><I><I><Q><T><V><S><K><D><V><N><T><T><I><M><E><L><L><I><M><V><Y><A><C><K><T><S><C><A><K><S><I><I><G><V><I><P><Y><F><P><Y><S><K><Q><C><K><M><R><K><R><G><S><I><V><S><K><L><L><A><S><M><M><C><K><A><G><L><T><H><L><I><T><M><D><L><H><Q><K><E><I><Q><G><F><F><N><I><P><V><D><N><L><R><A><S><P><F><L><L><Q><Y><I><Q><E><E><I><P><D><Y><R><N><A><V><I><V><A><K><S><P><A><S><A><K><R><A><Q><S><F><A><E><R><L><R><L><G><I><A><V><I><H><G><E><A><Q><D><A><E><S><D><L><V><D><G><R><H><S><P><P><M><V><R><S><V><A><A><I><H><P><S><L><E><I><P><M><L><I><P><K><E><K><P><P><I><T><V><V><G><D><V><G><G><R><I><A><I><I><V><D><D><I><I><D><D><V><D><S><F><L><A><A><A><E><T><L><K><E><R><G><A><Y><K><I><F><V><M><A><T><H><G><L><L><S><S><D><A><P><R><R><I><E><E><S><A><I><D><E><V><V><V><T><N><T><I><P><H><E><V><Q><K><L><Q><C><P><K><I><K><T><V><D><I><S><M><I><L><S><E><A><I><R><R><I><H><N><G><E><S><M><S><Y><L><F><R><N><I><G><L><D><D> | Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.<BOP> | O60256 |
Q02221 | CX6A2_HUMAN | Cytochrome c oxidase subunit VIA-muscle | Homo | <M><A><L><P><L><R><P><L><T><R><G><L><A><S><A><A><K><G><G><H><G><G><A><G><A><R><T><W><R><L><L><T><F><V><L><A><L><P><S><V><A><L><C><T><F><N><S><Y><L><H><S><G><H><R><P><R><P><E><F><R><P><Y><Q><H><L><R><I><R><T><K><P><Y><P><W><G><D><G><N><H><T><L><F><H><N><S><H><V><N><P><L><P><T><G><Y><E><H><P> | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons | Q02221 |
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