accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q9Y255
PRLD1_HUMAN
Px19-like protein
Homo
<M><V><K><Y><F><L><G><Q><S><V><L><R><S><S><W><D><Q><V><F><A><A><F><W><Q><R><Y><P><N><P><Y><S><K><H><V><L><T><E><D><I><V><H><R><E><V><T><P><D><Q><K><L><L><S><R><R><L><L><T><K><T><N><R><M><P><R><W><A><E><R><L><F><P><A><N><V><A><H><S><V><Y><V><L><E><D><S><I><V><D><P><Q><N><Q><T><M><T><T><F><T><W><N><I><N><H><A><R><L><M><V><V><E><E><R><C><V><Y><C><V><N><S><D><N><S><G><W><T><E><I><R><R><E><A><W><V><S><S><S><L><F><G><V><S><R><A><V><Q><E><F><G><L><A><R><F><K><S><N><V><T><K><T><M><K><G><F><E><Y><I><L><A><K><L><Q><G><E><A><P><S><K><T><L><V><E><T><A><K><E><A><K><E><K><A><K><E><T><A><L><A><A><T><E><K><A><K><D><L><A><S><K><A><A><T><K><K><Q><Q><Q><Q><Q><Q><F><V>
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.<BOP>
Q9Y255
Q9P0W2
HM20B_HUMAN
Structural DNA-binding protein BRAF35
Homo
<M><S><H><G><P><K><Q><P><G><A><A><A><A><P><A><G><G><K><A><P><G><Q><H><G><G><F><V><V><T><V><K><Q><E><R><G><E><G><P><R><A><G><E><K><G><S><H><E><E><E><P><V><K><K><R><G><W><P><K><G><K><K><R><K><K><I><L><P><N><G><P><K><A><P><V><T><G><Y><V><R><F><L><N><E><R><R><E><Q><I><R><T><R><H><P><D><L><P><F><P><E><I><T><K><M><L><G><A><E><W><S><K><L><Q><P><T><E><K><Q><R><Y><L><D><E><A><E><R><E><K><Q><Q><Y><M><K><E><L><R><A><Y><Q><Q><S><E><A><Y><K><M><C><T><E><K><I><Q><E><K><K><I><K><K><E><D><S><S><S><G><L><M><N><T><L><L><N><G><H><K><G><G><D><C><D><G><F><S><T><F><D><V><P><I><F><T><E><E><F><L><D><Q><N><K><A><R><E><A><E><L><R><R><L><R><K><M><N><V><A><F><E><E><Q><N><A><V><L><Q><R><H><T><Q><S><M><S><S><A><R><E><R><L><E><Q><E><L><A><L><E><E><R><R><T><L><A><L><Q><Q><Q><L><Q><A><V><R><Q><A><L><T><A><S><F><A><S><L><P><V><P><G><T><G><E><T><P><T><L><G><T><L><D><F><Y><M><A><R><L><H><G><A><I><E><R><D><P><A><Q><H><E><K><L><I><V><R><I><K><E><I><L><A><Q><V><A><S><E><H><L>
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.<BOP>
Q9P0W2
Q9H1Z9
TSN10_HUMAN
Oculospanin
Homo
<M><E><E><G><E><R><S><P><L><L><S><Q><E><T><A><G><Q><K><P><L><S><V><H><R><P><P><T><S><G><C><L><G><P><V><P><R><E><D><Q><A><E><A><W><G><C><S><C><C><P><P><E><T><K><H><Q><A><L><S><G><T><P><K><K><G><P><A><P><S><L><S><P><G><S><S><C><V><K><Y><L><I><F><L><S><N><F><P><F><S><L><L><G><L><L><A><L><A><I><G><L><W><G><L><A><V><K><G><S><L><G><S><D><L><G><G><P><L><P><T><D><P><M><L><G><L><A><L><G><G><L><V><V><S><A><A><S><L><A><G><C><L><G><A><L><C><E><N><T><C><L><L><R><G><F><S><G><G><I><L><A><F><L><V><L><E><A><V><A><G><A><L><V><V><A><L><W><G><P><L><Q><D><S><L><E><H><T><L><R><V><A><I><A><H><Y><Q><D><D><P><D><L><R><F><L><L><D><Q><V><Q><L><G><L><R><C><C><G><A><A><S><Y><Q><D><W><Q><Q><N><L><Y><F><N><C><S><S><P><G><V><Q><A><C><S><L><P><A><S><C><C><I><D><P><R><E><D><G><A><S><V><N><D><Q><C><G><F><G><V><L><R><L><D><A><D><A><A><Q><R><V><V><Y><L><E><G><C><G><P><P><L><R><R><W><L><R><A><N><L><A><A><S><G><G><Y><A><I><A><V><V><L><L><Q><G><A><E><L><L><L><A><A><R><L><L><G><A><L><A><A><R><S><G><A><A><Y><G><P><G><A><H><G><E><D><R><A><G><P><Q><S><P><S><P><G><A><P><P><A><A><K><P><A><R><G>
Regulates maturation of the transmembrane metalloprotease ADAM10.<BOP>
Q9H1Z9
Q6UWW8
EST3_HUMAN
Liver carboxylesterase 31 homolog
Homo
<M><E><R><A><V><R><V><E><S><G><V><L><V><G><V><V><C><L><L><L><A><C><P><A><T><A><T><G><P><E><V><A><Q><P><E><V><D><T><T><L><G><R><V><R><G><R><Q><V><G><V><K><G><T><D><R><L><V><N><V><F><L><G><I><P><F><A><Q><P><P><L><G><P><D><R><F><S><A><P><H><P><A><Q><P><W><E><G><V><R><D><A><S><T><A><P><P><M><C><L><Q><D><V><E><S><M><N><S><S><R><F><V><L><N><G><K><Q><Q><I><F><S><V><S><E><D><C><L><V><L><N><V><Y><S><P><A><E><V><P><A><G><S><G><R><P><V><M><V><W><V><H><G><G><A><L><I><T><G><A><A><T><S><Y><D><G><S><A><L><A><A><Y><G><D><V><V><V><V><T><V><Q><Y><R><L><G><V><L><G><F><F><S><T><G><D><E><H><A><P><G><N><Q><G><F><L><D><V><V><A><A><L><R><W><V><Q><E><N><I><A><P><F><G><G><D><L><N><C><V><T><V><F><G><G><S><A><G><G><S><I><I><S><G><L><V><L><S><P><V><A><A><G><L><F><H><R><A><I><T><Q><S><G><V><I><T><T><P><G><I><I><D><S><H><P><W><P><L><A><Q><K><I><A><N><T><L><A><C><S><S><S><S><P><A><E><M><V><Q><C><L><Q><Q><K><E><G><E><E><L><V><L><S><K><K><L><K><N><T><I><Y><P><L><T><V><D><G><T><V><F><P><K><S><P><K><E><L><L><K><E><K><P><F><H><S><V><P><F><L><M><G><V><N><N><H><E><F><S><W><L><I><P><R><G><W><G><L><L><D><T><M><E><Q><M><S><R><E><D><M><L><A><I><S><T><P><V><L><T><S><L><D><V><P><P><E><M><M><P><T><V><I><D><E><Y><L><G><S><N><S><D><A><Q><A><K><C><Q><A><F><Q><E><F><M><G><D><V><F><I><N><V><P><T><V><S><F><S><R><Y><L><R><D><S><G><S><P><V><F><F><Y><E><F><Q><H><R><P><S><S><F><A><K><I><K><P><A><W><V><K><A><D><H><G><A><E><G><A><F><V><F><G><G><P><F><L><M><D><E><S><S><R><L><A><F><P><E><A><T><E><E><E><K><Q><L><S><L><T><M><M><A><Q><W><T><H><F><A><R><T><G><D><P><N><S><K><A><L><P><P><W><P><Q><F><N><Q><A><E><Q><Y><L><E><I><N><P><V><P><R><A><G><Q><K><F><R><E><A><W><M><Q><F><W><S><E><T><L><P><S><K><I><Q><Q><W><H><Q><K><Q><K><N><R><K><A><Q><E><D><L>
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.<BOP>
Q6UWW8
P49821
NDUV1_HUMAN
NADH-ubiquinone oxidoreductase 51 kDa subunit
Homo
<M><L><A><T><R><R><L><L><G><W><S><L><P><A><R><V><S><V><R><F><S><G><D><T><T><A><P><K><K><T><S><F><G><S><L><K><D><E><D><R><I><F><T><N><L><Y><G><R><H><D><W><R><L><K><G><S><L><S><R><G><D><W><Y><K><T><K><E><I><L><L><K><G><P><D><W><I><L><G><E><I><K><T><S><G><L><R><G><R><G><G><A><G><F><P><T><G><L><K><W><S><F><M><N><K><P><S><D><G><R><P><K><Y><L><V><V><N><A><D><E><G><E><P><G><T><C><K><D><R><E><I><L><R><H><D><P><H><K><L><L><E><G><C><L><V><G><G><R><A><M><G><A><R><A><A><Y><I><Y><I><R><G><E><F><Y><N><E><A><S><N><L><Q><V><A><I><R><E><A><Y><E><A><G><L><I><G><K><N><A><C><G><S><G><Y><D><F><D><V><F><V><V><R><G><A><G><A><Y><I><C><G><E><E><T><A><L><I><E><S><I><E><G><K><Q><G><K><P><R><L><K><P><P><F><P><A><D><V><G><V><F><G><C><P><T><T><V><A><N><V><E><T><V><A><V><S><P><T><I><C><R><R><G><G><T><W><F><A><G><F><G><R><E><R><N><S><G><T><K><L><F><N><I><S><G><H><V><N><H><P><C><T><V><E><E><E><M><S><V><P><L><K><E><L><I><E><K><H><A><G><G><V><T><G><G><W><D><N><L><L><A><V><I><P><G><G><S><S><T><P><L><I><P><K><S><V><C><E><T><V><L><M><D><F><D><A><L><V><Q><A><Q><T><G><L><G><T><A><A><V><I><V><M><D><R><S><T><D><I><V><K><A><I><A><R><L><I><E><F><Y><K><H><E><S><C><G><Q><C><T><P><C><R><E><G><V><D><W><M><N><K><V><M><A><R><F><V><R><G><D><A><R><P><A><E><I><D><S><L><W><E><I><S><K><Q><I><E><G><H><T><I><C><A><L><G><D><G><A><A><W><P><V><Q><G><L><I><R><H><F><R><P><E><L><E><E><R><M><Q><R><F><A><Q><Q><H><Q><A><R><Q><A><A><S>
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.<BOP>
P49821
Q96EY7
PTCD3_HUMAN
Transformation-related gene 15 protein
Homo
<M><A><V><V><S><A><V><R><W><L><G><L><R><S><R><L><G><Q><P><L><T><G><R><R><A><G><L><C><E><Q><A><R><S><C><R><F><Y><S><G><S><A><T><L><S><K><V><E><G><T><D><V><T><G><I><E><E><V><V><I><P><K><K><K><T><W><D><K><V><A><V><L><Q><A><L><A><S><T><V><N><R><D><T><T><A><V><P><Y><V><F><Q><D><D><P><Y><L><M><P><A><S><S><L><E><S><R><S><F><L><L><A><K><K><S><G><E><N><V><A><K><F><I><I><N><S><Y><P><K><Y><F><Q><K><D><I><A><E><P><H><I><P><C><L><M><P><E><Y><F><E><P><Q><I><K><D><I><S><E><A><A><L><K><E><R><I><E><L><R><K><V><K><A><S><V><D><M><F><D><Q><L><L><Q><A><G><T><T><V><S><L><E><T><T><N><S><L><L><D><L><L><C><Y><Y><G><D><Q><E><P><S><T><D><Y><H><F><Q><Q><T><G><Q><S><E><A><L><E><E><E><N><D><E><T><S><R><R><K><A><G><H><Q><F><G><V><T><W><R><A><K><N><N><A><E><R><I><F><S><L><M><P><E><K><N><E><H><S><Y><C><T><M><I><R><G><M><V><K><H><R><A><Y><E><Q><A><L><N><L><Y><T><E><L><L><N><N><R><L><H><A><D><V><Y><T><F><N><A><L><I><E><A><T><V><C><A><I><N><E><K><F><E><E><K><W><S><K><I><L><E><L><L><R><H><M><V><A><Q><K><V><K><P><N><L><Q><T><F><N><T><I><L><K><C><L><R><R><F><H><V><F><A><R><S><P><A><L><Q><V><L><R><E><M><K><A><I><G><I><E><P><S><L><A><T><Y><H><H><I><I><R><L><F><D><Q><P><G><D><P><L><K><R><S><S><F><I><I><Y><D><I><M><N><E><L><M><G><K><R><F><S><P><K><D><P><D><D><D><K><F><F><Q><S><A><M><S><I><C><S><S><L><R><D><L><E><L><A><Y><Q><V><H><G><L><L><K><T><G><D><N><W><K><F><I><G><P><D><Q><H><R><N><F><Y><Y><S><K><F><F><D><L><I><C><L><M><E><Q><I><D><V><T><L><K><W><Y><E><D><L><I><P><S><A><Y><F><P><H><S><Q><T><M><I><H><L><L><Q><A><L><D><V><A><N><R><L><E><V><I><P><K><I><W><K><D><S><K><E><Y><G><H><T><F><R><S><D><L><R><E><E><I><L><M><L><M><A><R><D><K><H><P><P><E><L><Q><V><A><F><A><D><C><A><A><D><I><K><S><A><Y><E><S><Q><P><I><R><Q><T><A><Q><D><W><P><A><T><S><L><N><C><I><A><I><L><F><L><R><A><G><R><T><Q><E><A><W><K><M><L><G><L><F><R><K><H><N><K><I><P><R><S><E><L><L><N><E><L><M><D><S><A><K><V><S><N><S><P><S><Q><A><I><E><V><V><E><L><A><S><A><F><S><L><P><I><C><E><G><L><T><Q><R><V><M><S><D><F><A><I><N><Q><E><Q><K><E><A><L><S><N><L><T><A><L><T><S><D><S><D><T><D><S><S><S><D><S><D><S><D><T><S><E><G><K>
Mitochondrial RNA-binding protein that has a role in mitochondrial translation.<BOP>
Q96EY7
Q8TBZ5
ZN502_HUMAN
Zinc finger protein 502
Homo
<M><L><N><M><Q><G><A><E><E><R><D><I><R><R><E><T><C><P><G><W><V><N><K><N><K><P><A><L><E><Q><D><V><C><K><I><D><S><S><G><I><V><V><K><R><F><Q><E><D><E><Y><Q><D><S><T><F><E><E><K><Y><A><C><E><G><M><K><E><N><S><P><R><E><I><A><E><S><C><L><F><Q><E><G><G><F><G><R><I><T><F><I><H><K><E><A><P><P><E><I><I><S><Q><G><Y><N><F><E><K><S><L><L><L><T><S><S><L><V><T><R><L><R><V><S><T><E><E><S><L><H><Q><W><E><T><S><N><I><Q><T><N><D><I><S><D><Q><S><K><C><P><T><L><C><T><Q><K><K><S><W><K><C><N><E><C><G><K><T><F><T><Q><S><S><S><L><T><Q><H><Q><R><T><H><T><G><E><R><P><Y><T><C><E><E><C><G><K><A><F><S><R><S><S><F><L><V><Q><H><Q><R><I><H><T><G><V><K><P><Y><G><C><E><Q><C><G><K><T><F><R><C><R><S><F><L><T><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><N><S><F><R><N><H><S><H><L><T><E><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><R><C><G><K><A><F><N><Q><N><T><H><L><I><H><H><Q><R><I><H><T><G><E><K><P><Y><I><C><S><E><C><G><S><S><F><R><K><H><S><N><L><T><Q><H><Q><R><I><H><T><G><E><K><P><H><K><C><D><E><C><G><K><T><F><Q><T><K><A><N><L><S><Q><H><Q><R><I><H><S><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><C><Q><S><P><S><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><T><Q><S><T><P><L><T><K><H><Q><R><I><H><T><G><E><R><P><Y><K><C><S><E><C><G><K><A><F><I><Q><S><I><C><L><I><R><H><Q><R><S><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><G><F><N><Q><N><T><C><L><T><Q><H><M><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><A><H><S><S><S><L><T><E><H><H><R><T><H><T><G><E><K><L><Y><K><C><S><E><C><E><K><T><F><R><K><Y><A><H><L><S><E><H><Y><R><I><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><F><F><R><H><S><S><V><L><F><R><H><Q><K><L><H><S><G><D>
May be involved in transcriptional regulation.<BOP>
Q8TBZ5
Q9Y2X8
UB2D4_HUMAN
Ubiquitin-protein ligase D4
Homo
<M><A><L><K><R><I><Q><K><E><L><T><D><L><Q><R><D><P><P><A><Q><C><S><A><G><P><V><G><D><D><L><F><H><W><Q><A><T><I><M><G><P><N><D><S><P><Y><Q><G><G><V><F><F><L><T><I><H><F><P><T><D><Y><P><F><K><P><P><K><V><A><F><T><T><K><I><Y><H><P><N><I><N><S><N><G><S><I><C><L><D><I><L><R><S><Q><W><S><P><A><L><T><V><S><K><V><L><L><S><I><C><S><L><L><C><D><P><N><P><D><D><P><L><V><P><E><I><A><H><T><Y><K><A><D><R><E><K><Y><N><R><L><A><R><E><W><T><Q><K><Y><A><M>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.<BOP>
Q9Y2X8
Q8IXL7
MSRB3_HUMAN
Methionine-R-sulfoxide reductase B3
Homo
<M><S><P><R><R><T><L><P><R><P><L><S><L><C><L><S><L><C><L><C><L><C><L><A><A><A><L><G><S><A><Q><S><G><S><C><R><D><K><K><N><C><K><V><V><F><S><Q><Q><E><L><R><K><R><L><T><P><L><Q><Y><H><V><T><Q><E><K><G><T><E><S><A><F><E><G><E><Y><T><H><H><K><D><P><G><I><Y><K><C><V><V><C><G><T><P><L><F><K><S><E><T><K><F><D><S><G><S><G><W><P><S><F><H><D><V><I><N><S><E><A><I><T><F><T><D><D><F><S><Y><G><M><H><R><V><E><T><S><C><S><Q><C><G><A><H><L><G><H><I><F><D><D><G><P><R><P><T><G><K><R><Y><C><I><N><S><A><A><L><S><F><T><P><A><D><S><S><G><T><A><E><G><G><S><G><V><A><S><P><A><Q><A><D><K><A><E><L>
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.<BOP>
Q8IXL7
Q06609
RAD51_HUMAN
RAD51 homolog A
Homo
<M><A><M><Q><M><Q><L><E><A><N><A><D><T><S><V><E><E><E><S><F><G><P><Q><P><I><S><R><L><E><Q><C><G><I><N><A><N><D><V><K><K><L><E><E><A><G><F><H><T><V><E><A><V><A><Y><A><P><K><K><E><L><I><N><I><K><G><I><S><E><A><K><A><D><K><I><L><A><E><A><A><K><L><V><P><M><G><F><T><T><A><T><E><F><H><Q><R><R><S><E><I><I><Q><I><T><T><G><S><K><E><L><D><K><L><L><Q><G><G><I><E><T><G><S><I><T><E><M><F><G><E><F><R><T><G><K><T><Q><I><C><H><T><L><A><V><T><C><Q><L><P><I><D><R><G><G><G><E><G><K><A><M><Y><I><D><T><E><G><T><F><R><P><E><R><L><L><A><V><A><E><R><Y><G><L><S><G><S><D><V><L><D><N><V><A><Y><A><R><A><F><N><T><D><H><Q><T><Q><L><L><Y><Q><A><S><A><M><M><V><E><S><R><Y><A><L><L><I><V><D><S><A><T><A><L><Y><R><T><D><Y><S><G><R><G><E><L><S><A><R><Q><M><H><L><A><R><F><L><R><M><L><L><R><L><A><D><E><F><G><V><A><V><V><I><T><N><Q><V><V><A><Q><V><D><G><A><A><M><F><A><A><D><P><K><K><P><I><G><G><N><I><I><A><H><A><S><T><T><R><L><Y><L><R><K><G><R><G><E><T><R><I><C><K><I><Y><D><S><P><C><L><P><E><A><E><A><M><F><A><I><N><A><D><G><V><G><D><A><K><D>
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) . Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange . Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template . Recruited to resolve stalled replication forks during replication stress . Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR . Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 . Also involved in interstrand cross-link repair .<BOP>
Q06609
Q8N7C0
LRC52_HUMAN
BK channel auxiliary gamma subunit LRRC52
Homo
<M><S><L><A><S><G><P><G><P><G><W><L><L><F><S><F><G><M><G><L><V><S><G><S><K><C><P><N><N><C><L><C><Q><A><Q><E><V><I><C><T><G><K><Q><L><T><E><Y><P><L><D><I><P><L><N><T><R><R><L><F><L><N><E><N><R><I><T><S><L><P><A><M><H><L><G><L><L><S><D><L><V><Y><L><D><C><Q><N><N><R><I><R><E><V><M><D><Y><T><F><I><G><V><F><K><L><I><Y><L><D><L><S><S><N><N><L><T><S><I><S><P><F><T><F><S><V><L><S><N><L><V><Q><L><N><I><A><N><N><P><H><L><L><S><L><H><K><F><T><F><A><N><T><T><S><L><R><Y><L><D><L><R><N><T><G><L><Q><T><L><D><S><A><A><L><Y><H><L><T><T><L><E><T><L><F><L><S><G><N><P><W><K><C><N><C><S><F><L><D><F><A><I><F><L><I><V><F><H><M><D><P><S><D><D><L><N><A><T><C><V><E><P><T><E><L><T><G><W><P><I><T><R><V><G><N><P><L><R><Y><M><C><I><T><H><L><D><H><K><D><Y><I><F><L><L><L><I><G><F><C><I><F><A><A><G><T><V><A><A><W><L><T><G><V><C><A><V><L><Y><Q><N><T><R><H><K><S><S><E><E><D><E><D><E><A><G><T><R><V><E><V><S><R><R><I><F><Q><T><Q><T><S><S><V><Q><E><F><P><Q><L><I>
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties.<BOP>
Q8N7C0
Q9H4L4
SENP3_HUMAN
Sentrin/SUMO-specific protease SENP3
Homo
<M><K><E><T><I><Q><G><T><G><S><W><G><P><E><P><P><G><P><G><I><P><P><A><Y><S><S><P><R><R><E><R><L><R><W><P><P><P><P><K><P><R><L><K><S><G><G><G><F><G><P><D><P><G><S><G><T><T><V><P><A><R><R><L><P><V><P><R><P><S><F><D><A><S><A><S><E><E><E><E><E><E><E><E><E><E><D><E><D><E><E><E><E><V><A><A><W><R><L><P><P><R><W><S><Q><L><G><T><S><Q><R><P><R><P><S><R><P><T><H><R><K><T><C><S><Q><R><R><R><R><A><M><R><A><F><R><M><L><L><Y><S><K><S><T><S><L><T><F><H><W><K><L><W><G><R><H><R><G><R><R><R><G><L><A><H><P><K><N><H><L><S><P><Q><Q><G><G><A><T><P><Q><V><P><S><P><C><C><R><F><D><S><P><R><G><P><P><P><P><R><L><G><L><L><G><A><L><M><A><E><D><G><V><R><G><S><P><P><V><P><S><G><P><P><M><E><E><D><G><L><R><W><T><P><K><S><P><L><D><P><D><S><G><L><L><S><C><T><L><P><N><G><F><G><G><Q><S><G><P><E><G><E><R><S><L><A><P><P><D><A><S><I><L><I><S><N><V><C><S><I><G><D><H><V><A><Q><E><L><F><Q><G><S><D><L><G><M><A><E><E><A><E><R><P><G><E><K><A><G><Q><H><S><P><L><R><E><E><H><V><T><C><V><Q><S><I><L><D><E><F><L><Q><T><Y><G><S><L><I><P><L><S><T><D><E><V><V><E><K><L><E><D><I><F><Q><Q><E><F><S><T><P><S><R><K><G><L><V><L><Q><L><I><Q><S><Y><Q><R><M><P><G><N><A><M><V><R><G><F><R><V><A><Y><K><R><H><V><L><T><M><D><D><L><G><T><L><Y><G><Q><N><W><L><N><D><Q><V><M><N><M><Y><G><D><L><V><M><D><T><V><P><E><K><V><H><F><F><N><S><F><F><Y><D><K><L><R><T><K><G><Y><D><G><V><K><R><W><T><K><N><V><D><I><F><N><K><E><L><L><L><I><P><I><H><L><E><V><H><W><S><L><I><S><V><D><V><R><R><R><T><I><T><Y><F><D><S><Q><R><T><L><N><R><R><C><P><K><H><I><A><K><Y><L><Q><A><E><A><V><K><K><D><R><L><D><F><H><Q><G><W><K><G><Y><F><K><M><N><V><A><R><Q><N><N><D><S><D><C><G><A><F><V><L><Q><Y><C><K><H><L><A><L><S><Q><P><F><S><F><T><Q><Q><D><M><P><K><L><R><R><Q><I><Y><K><E><L><C><H><C><K><L><T><V>
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates . Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability . Deconjugates SUMO2 and SUMO3 from CDCA8 . Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 . Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 . Plays a role in the regulation of sumoylation status of ZNF148 . Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Deconjugates SUMO2 from KAT5 .<BOP>
Q9H4L4
Q6Y288
B3GLT_HUMAN
Beta-3-glycosyltransferase-like
Homo
<M><R><P><P><A><C><W><W><L><L><A><P><P><A><L><L><A><L><L><T><C><S><L><A><F><G><L><A><S><E><D><T><K><K><E><V><K><Q><S><Q><D><L><E><K><S><G><I><S><R><K><N><D><I><D><L><K><G><I><V><F><V><I><Q><S><Q><S><N><S><F><H><A><K><R><A><E><Q><L><K><K><S><I><L><K><Q><A><A><D><L><T><Q><E><L><P><S><V><L><L><L><H><Q><L><A><K><Q><E><G><A><W><T><I><L><P><L><L><P><H><F><S><V><T><Y><S><R><N><S><S><W><I><F><F><C><E><E><E><T><R><I><Q><I><P><K><L><L><E><T><L><R><R><Y><D><P><S><K><E><W><F><L><G><K><A><L><H><D><E><E><A><T><I><I><H><H><Y><A><F><S><E><N><P><T><V><F><K><Y><P><D><F><A><A><G><W><A><L><S><I><P><L><V><N><K><L><T><K><R><L><K><S><E><S><L><K><S><D><F><T><I><D><L><K><H><E><I><A><L><Y><I><W><D><K><G><G><G><P><P><L><T><P><V><P><E><F><C><T><N><D><V><D><F><Y><C><A><T><T><F><H><S><F><L><P><L><C><R><K><P><V><K><K><K><D><I><F><V><A><V><K><T><C><K><K><F><H><G><D><R><I><P><I><V><K><Q><T><W><E><S><Q><A><S><L><I><E><Y><Y><S><D><Y><T><E><N><S><I><P><T><V><D><L><G><I><P><N><T><D><R><G><H><C><G><K><T><F><A><I><L><E><R><F><L><N><R><S><Q><D><K><T><A><W><L><V><I><V><D><D><D><T><L><I><S><I><S><R><L><Q><H><L><L><S><C><Y><D><S><G><E><P><V><F><L><G><E><R><Y><G><Y><G><L><G><T><G><G><Y><S><Y><I><T><G><G><G><G><M><V><F><S><R><E><A><V><R><R><L><L><A><S><K><C><R><C><Y><S><N><D><A><P><D><D><M><V><L><G><M><C><F><S><G><L><G><I><P><V><T><H><S><P><L><F><H><Q><A><R><P><V><D><Y><P><K><D><Y><L><S><H><Q><V><P><I><S><F><H><K><H><W><N><I><D><P><V><K><V><Y><F><T><W><L><A><P><S><D><E><D><K><A><R><Q><E><T><Q><K><G><F><R><E><E><L>
O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.<BOP>
Q6Y288
P58215
LOXL3_HUMAN
Lysyl oxidase-like protein 3
Homo
<M><R><P><V><S><V><W><Q><W><S><P><W><G><L><L><L><C><L><L><C><S><S><C><L><G><S><P><S><P><S><T><G><P><E><K><K><A><G><S><Q><G><L><R><F><R><L><A><G><F><P><R><K><P><Y><E><G><R><V><E><I><Q><R><A><G><E><W><G><T><I><C><D><D><D><F><T><L><Q><A><A><H><I><L><C><R><E><L><G><F><T><E><A><T><G><W><T><H><S><A><K><Y><G><P><G><T><G><R><I><W><L><D><N><L><S><C><S><G><T><E><Q><S><V><T><E><C><A><S><R><G><W><G><N><S><D><C><T><H><D><E><D><A><G><V><I><C><K><D><Q><R><L><P><G><F><S><D><S><N><V><I><E><V><E><H><H><L><Q><V><E><E><V><R><I><R><P><A><V><G><W><G><R><R><P><L><P><V><T><E><G><L><V><E><V><R><L><P><D><G><W><S><Q><V><C><D><K><G><W><S><A><H><N><S><H><V><V><C><G><M><L><G><F><P><S><E><K><R><V><N><A><A><F><Y><R><L><L><A><Q><R><Q><Q><H><S><F><G><L><H><G><V><A><C><V><G><T><E><A><H><L><S><L><C><S><L><E><F><Y><R><A><N><D><T><A><R><C><P><G><G><G><P><A><V><V><S><C><V><P><G><P><V><Y><A><A><S><S><G><Q><K><K><Q><Q><Q><S><K><P><Q><G><E><A><R><V><R><L><K><G><G><A><H><P><G><E><G><R><V><E><V><L><K><A><S><T><W><G><T><V><C><D><R><K><W><D><L><H><A><A><S><V><V><C><R><E><L><G><F><G><S><A><R><E><A><L><S><G><A><R><M><G><Q><G><M><G><A><I><H><L><S><E><V><R><C><S><G><Q><E><L><S><L><W><K><C><P><H><K><N><I><T><A><E><D><C><S><H><S><Q><D><A><G><V><R><C><N><L><P><Y><T><G><A><E><T><R><I><R><L><S><G><G><R><S><Q><H><E><G><R><V><E><V><Q><I><G><G><P><G><P><L><R><W><G><L><I><C><G><D><D><W><G><T><L><E><A><M><V><A><C><R><Q><L><G><L><G><Y><A><N><H><G><L><Q><E><T><W><Y><W><D><S><G><N><I><T><E><V><V><M><S><G><V><R><C><T><G><T><E><L><S><L><D><Q><C><A><H><H><G><T><H><I><T><C><K><R><T><G><T><R><F><T><A><G><V><I><C><S><E><T><A><S><D><L><L><L><H><S><A><L><V><Q><E><T><A><Y><I><E><D><R><P><L><H><M><L><Y><C><A><A><E><E><N><C><L><A><S><S><A><R><S><A><N><W><P><Y><G><H><R><R><L><L><R><F><S><S><Q><I><H><N><L><G><R><A><D><F><R><P><K><A><G><R><H><S><W><V><W><H><E><C><H><G><H><Y><H><S><M><D><I><F><T><H><Y><D><I><L><T><P><N><G><T><K><V><A><E><G><H><K><A><S><F><C><L><E><D><T><E><C><Q><E><D><V><S><K><R><Y><E><C><A><N><F><G><E><Q><G><I><T><V><G><C><W><D><L><Y><R><H><D><I><D><C><Q><W><I><D><I><T><D><V><K><P><G><N><Y><I><L><Q><V><V><I><N><P><N><F><E><V><A><E><S><D><F><T><N><N><A><M><K><C><N><C><K><Y><D><G><H><R><I><W><V><H><N><C><H><I><G><D><A><F><S><E><E><A><N><R><R><F><E><R><Y><P><G><Q><T><S><N><Q><I><I>
Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV .<BOP>
P58215
P52306
GDS1_HUMAN
SMG P21 stimulatory GDP/GTP exchange protein
Homo
<M><D><N><L><S><D><T><L><K><K><L><K><I><T><A><V><D><K><T><E><D><S><L><E><G><C><L><D><C><L><L><Q><A><L><A><Q><N><N><T><E><T><S><E><K><I><Q><A><S><G><I><L><Q><L><F><A><S><L><L><T><P><Q><S><S><C><K><A><K><V><A><N><I><I><A><E><V><A><K><N><E><F><M><R><I><P><C><V><D><A><G><L><I><S><P><L><V><Q><L><L><N><S><K><D><Q><E><V><L><L><Q><T><G><R><A><L><G><N><I><C><Y><D><S><H><E><G><R><S><A><V><D><Q><A><G><G><A><Q><I><V><I><D><H><L><R><S><L><C><S><I><T><D><P><A><N><E><K><L><L><T><V><F><C><G><M><L><M><N><Y><S><N><E><N><D><S><L><Q><A><Q><L><I><N><M><G><V><I><P><T><L><V><K><L><L><G><I><H><C><Q><N><A><A><L><T><E><M><C><L><V><A><F><G><N><L><A><E><L><E><S><S><K><E><Q><F><A><S><T><N><I><A><E><E><L><V><K><L><F><K><K><Q><I><E><H><D><K><R><E><M><I><F><E><V><L><A><P><L><A><E><N><D><A><I><K><L><Q><L><V><E><A><G><L><V><E><C><L><L><E><I><V><Q><Q><K><V><D><S><D><K><E><D><D><I><T><E><L><K><T><G><S><D><L><M><V><L><L><L><L><G><D><E><S><M><Q><K><L><F><E><G><G><K><G><S><V><F><Q><R><V><L><S><W><I><P><S><N><N><H><Q><L><Q><L><A><G><A><L><A><I><A><N><F><A><R><N><D><A><N><C><I><H><M><V><D><N><G><I><V><E><K><L><M><D><L><L><D><R><H><V><E><D><G><N><V><T><V><Q><H><A><A><L><S><A><L><R><N><L><A><I><P><V><I><N><K><A><K><M><L><S><A><G><V><T><E><A><V><L><K><F><L><K><S><E><M><P><P><V><Q><F><K><L><L><G><T><L><R><M><L><I><D><A><Q><A><E><A><A><E><Q><L><G><K><N><V><K><L><V><E><R><L><V><E><W><C><E><A><K><D><H><A><G><V><M><G><E><S><N><R><L><L><S><A><L><I><R><H><S><K><S><K><D><V><I><K><T><I><V><Q><S><G><G><I><K><H><L><V><T><M><A><T><S><E><H><V><I><M><Q><N><E><A><L><V><A><L><A><L><I><A><A><L><E><L><G><T><A><E><K><D><L><E><S><A><K><L><V><Q><I><L><H><R><L><L><A><D><E><R><S><A><P><E><I><K><Y><N><S><M><V><L><I><C><A><L><M><G><S><E><C><L><H><K><E><V><Q><D><L><A><F><L><D><V><V><S><K><L><R><S><H><E><N><K><S><V><A><Q><Q><A><S><L><T><E><Q><R><L><T><V><E><S>
Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA . Acts as a GEF for RHOC . Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases . Escorts RAC1 to the nucleus .<BOP>
P52306
P18124
RL7_HUMAN
Large ribosomal subunit protein uL30
Homo
<M><E><G><V><E><E><K><K><K><E><V><P><A><V><P><E><T><L><K><K><K><R><R><N><F><A><E><L><K><I><K><R><L><R><K><K><F><A><Q><K><M><L><R><K><A><R><R><K><L><I><Y><E><K><A><K><H><Y><H><K><E><Y><R><Q><M><Y><R><T><E><I><R><M><A><R><M><A><R><K><A><G><N><F><Y><V><P><A><E><P><K><L><A><F><V><I><R><I><R><G><I><N><G><V><S><P><K><V><R><K><V><L><Q><L><L><R><L><R><Q><I><F><N><G><T><F><V><K><L><N><K><A><S><I><N><M><L><R><I><V><E><P><Y><I><A><W><G><Y><P><N><L><K><S><V><N><E><L><I><Y><K><R><G><Y><G><K><I><N><K><K><R><I><A><L><T><D><N><A><L><I><A><R><S><L><G><K><Y><G><I><I><C><M><E><D><L><I><H><E><I><Y><T><V><G><K><R><F><K><E><A><N><N><F><L><W><P><F><K><L><S><S><P><R><G><G><M><K><K><K><T><T><H><F><V><E><G><G><D><A><G><N><R><E><D><Q><I><N><R><L><I><R><R><M><N>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell . Binds to G-rich structures in 28S rRNA and in mRNAs . Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs .<BOP>
P18124
Q6UXB2
CXL17_HUMAN
4-Cys CXCL17
Homo
<M><K><V><L><I><S><S><L><L><L><L><L><P><L><M><L><M><S><M><V><S><S><S><L><N><P><G><V><A><R><G><H><R><D><R><G><Q><A><S><R><R><W><L><Q><E><G><G><Q><E><C><E><C><K><D><W><F><L><R><A><P><R><R><K><F><M><T><V><S><G><L><P><K><K><Q><C><P><C><D><H><F><K><G><N><V><K><K><T><R><H><Q><R><H><H><R><K><P><N><K><H><S><R><A><C><Q><Q><F><L><K><Q><C><Q><L><R><S><F><A><L><P><L>
Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.<BOP>
Q6UXB2
A6NNS2
DRS7C_HUMAN
Short-chain dehydrogenase/reductase family 32C member 2
Homo
<M><G><V><M><A><M><L><M><L><P><L><L><L><L><G><I><S><G><L><L><F><I><Y><Q><E><V><S><R><L><W><S><K><S><A><V><Q><N><K><V><V><V><I><T><D><A><I><S><G><L><G><K><E><C><A><R><V><F><H><T><G><G><A><R><L><V><L><C><G><K><N><W><E><R><L><E><N><L><Y><D><A><L><I><S><V><A><D><P><S><K><Q><T><F><T><P><K><L><V><L><L><D><L><S><D><I><S><C><V><P><D><V><A><K><E><V><L><D><C><Y><G><C><V><D><I><L><I><N><N><A><S><V><K><V><K><G><P><A><H><K><I><S><L><E><L><D><K><K><I><M><D><A><N><Y><F><G><P><I><T><L><T><K><A><L><L><P><N><M><I><S><R><R><T><G><Q><I><V><L><V><N><N><I><Q><G><K><F><G><I><P><F><R><T><T><Y><A><A><S><K><H><A><A><L><G><F><F><D><C><L><R><A><E><V><E><E><Y><D><V><V><I><S><T><V><S><P><T><F><I><R><S><Y><H><V><Y><P><E><Q><G><N><W><E><A><S><I><W><K><F><F><F><R><K><L><T><Y><G><V><H><P><V><E><V><A><E><E><V><M><R><T><V><R><R><K><K><Q><E><V><F><M><A><N><P><I><P><K><A><A><V><Y><V><R><T><F><F><P><E><F><F><F><A><V><V><A><C><G><V><K><E><K><L><N><V><P><E><E><G>
NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid.<BOP>
A6NNS2
Q5T0L3
SPT46_HUMAN
Spermatogenesis-associated protein 46
Homo
<M><E><N><F><S><L><L><S><I><S><G><P><P><I><S><S><S><A><L><S><A><F><P><D><I><M><F><S><R><A><T><S><L><P><D><I><A><K><T><A><V><P><T><E><A><S><S><P><A><Q><A><L><P><P><Q><Y><Q><S><I><I><V><R><Q><G><I><Q><N><T><A><L><S><P><D><C><S><L><G><D><T><Q><H><G><E><K><L><R><R><N><C><T><I><Y><R><P><W><F><S><P><Y><S><Y><F><V><C><A><D><K><E><S><Q><L><E><A><Y><D><F><P><E><V><Q><Q><D><E><G><K><W><D><N><C><L><S><E><D><M><A><E><N><I><C><S><S><S><S><S><P><E><N><T><C><P><R><E><A><T><K><K><S><R><H><G><L><D><S><I><T><S><Q><D><I><L><M><A><S><R><W><H><P><A><Q><Q><N><G><Y><K><C><V><A><C><C><R><M><Y><P><T><L><D><F><L><K><S><H><I><K><R><G><F><R><E><G><F><S><C><K><V><Y><Y><R><K><L><K><A><L><W><S><K><E><Q><K><A><R><L><G><D><R><L><S><S><G><S><C><Q><A><F><N><S><P><A><E><H><L><R><Q><I><G><G><E><A><Y><L><C><L>
Plays a role in spermiogenesis and fertilization.<BOP>
Q5T0L3
Q13585
MTR1L_HUMAN
H9
Homo
<M><G><P><T><L><A><V><P><T><P><Y><G><C><I><G><C><K><L><P><Q><P><E><Y><P><P><A><L><I><I><F><M><F><C><A><M><V><I><T><I><V><V><D><L><I><G><N><S><M><V><I><L><A><V><T><K><N><K><K><L><R><N><S><G><N><I><F><V><V><S><L><S><V><A><D><M><L><V><A><I><Y><P><Y><P><L><M><L><H><A><M><S><I><G><G><W><D><L><S><Q><L><Q><C><Q><M><V><G><F><I><T><G><L><S><V><V><G><S><I><F><N><I><V><A><I><A><I><N><R><Y><C><Y><I><C><H><S><L><Q><Y><E><R><I><F><S><V><R><N><T><C><I><Y><L><V><I><T><W><I><M><T><V><L><A><V><L><P><N><M><Y><I><G><T><I><E><Y><D><P><R><T><Y><T><C><I><F><N><Y><L><N><N><P><V><F><T><V><T><I><V><C><I><H><F><V><L><P><L><L><I><V><G><F><C><Y><V><R><I><W><T><K><V><L><A><A><R><D><P><A><G><Q><N><P><D><N><Q><L><A><E><V><R><N><F><L><T><M><F><V><I><F><L><L><F><A><V><C><W><C><P><I><N><V><L><T><V><L><V><A><V><S><P><K><E><M><A><G><K><I><P><N><W><L><Y><L><A><A><Y><F><I><A><Y><F><N><S><C><L><N><A><V><I><Y><G><L><L><N><E><N><F><R><R><E><Y><W><T><I><F><H><A><M><R><H><P><I><I><F><F><S><G><L><I><S><D><I><R><E><M><Q><E><A><R><T><L><A><R><A><R><A><H><A><R><D><Q><A><R><E><Q><D><R><A><H><A><C><P><A><V><E><E><T><P><M><N><V><R><N><V><P><L><P><G><D><A><A><A><G><H><P><D><R><A><S><G><H><P><K><P><H><S><R><S><S><S><A><Y><R><K><S><A><S><T><H><H><K><S><V><F><S><H><S><K><A><A><S><G><H><L><K><P><V><S><G><H><S><K><P><A><S><G><H><P><K><S><A><T><V><Y><P><K><P><A><S><V><H><F><K><A><D><S><V><H><F><K><G><D><S><V><H><F><K><P><D><S><V><H><F><K><P><A><S><S><N><P><K><P><I><T><G><H><H><V><S><A><G><S><H><S><K><S><A><F><S><A><A><T><S><H><P><K><P><T><T><G><H><I><K><P><A><T><S><H><A><E><P><T><T><A><D><Y><P><K><P><A><T><T><S><H><P><K><P><T><A><A><D><N><P><E><L><S><A><S><H><C><P><E><I><P><A><I><A><H><P><V><S><D><D><S><D><L><P><E><S><A><S><S><P><A><A><G><P><T><K><P><A><A><S><Q><L><E><S><D><T><I><A><D><L><P><D><P><T><V><V><T><T><S><T><N><D><Y><H><D><V><V><V><I><D><V><E><D><D><P><D><E><M><A><V>
Does not bind melatonin.<BOP>
Q13585
A8MWX3
WASH4_HUMAN
Protein FAM39CP
Homo
<M><S><G><V><M><C><L><K><A><S><D><T><W><A><S><G><I><R><S><Q><P><Q><G><C><L><G><K><W><R><S><M><R><C><K><H><T><R><M><H><L><A><H><L><G><N><S><R><Q><L><I><S><L><G><P><P><R><T><R><E><D><G><S><R><I><S><Q><Q><V><E><Q><S><R><S><Q><V><Q><A><I><G><E><K><V><S><L><A><Q><A><K><I><E><K><I><K><G><S><K><K><A><I><K><V><F><S><S><A><K><Y><P><A><P><E><R><L><Q><E><Y><G><S><I><F><T><D><A><Q><D><P><G><L><Q><R><R><P><R><H><R><I><Q><S><K><Q><R><P><L><D><E><R><A><L><Q><E><K><L><K><D><F><P><V><C><V><S><T><K><P><E><P><E><D><D><A><E><E><G><L><G><G><L><P><S><N><I><S><S><V><S><S><L><L><L><F><N><T><T><E><N><L><Y><K><K><Y><V><F><L><D><P><L><A><G><A><V><T><K><T><H><V><M><L><G><A><E><T><E><E><K><L><F><D><A><P><L><S><I><S><K><R><E><Q><L><E><Q><Q><V><P><E><N><Y><F><Y><V><P><D><L><G><Q><V><P><E><I><D><V><P><S><Y><L><P><D><L><P><G><I><A><N><D><L><M><Y><I><A><D><L><G><P><G><I><A><P><S><A><P><G><T><I><P><E><L><P><T><F><H><T><E><V><A><E><P><L><K><V><D><L><Q><D><G><V><L><T><P><P><P><P><P><P><P><P><P><P><A><P><E><V><L><A><S><A><P><P><L><P><P><S><T><A><A><P><V><G><Q><G><A><R><Q><D><D><S><S><S><S><A><S><P><S><V><Q><G><A><P><R><E><V><V><D><P><S><G><G><W><A><T><L><L><E><S><I><R><Q><A><G><G><I><G><K><A><K><L><R><S><M><K><E><R><K><L><E><K><Q><Q><Q><K><E><Q><E><Q><V><R><A><T><S><Q><G><G><H><L><M><S><D><L><F><N><K><L><V><M><R><R><K><G><I><S><G><K><G><P><G><A><G><D><G><P><G><G><A><F><A><R><V><S><D><S><I><P><P><L><P><P><P><Q><Q><P><Q><A><E><D><E><D><D><W><E><S>
May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.<BOP>
A8MWX3
Q9BY43
CHM4A_HUMAN
Vacuolar protein sorting-associated protein 32-1
Homo
<M><S><G><L><G><R><L><F><G><K><G><K><K><E><K><G><P><T><P><E><E><A><I><Q><K><L><K><E><T><E><K><I><L><I><K><K><Q><E><F><L><E><Q><K><I><Q><Q><E><L><Q><T><A><K><K><Y><G><T><K><N><K><R><A><A><L><Q><A><L><R><R><K><K><R><F><E><Q><Q><L><A><Q><T><D><G><T><L><S><T><L><E><F><Q><R><E><A><I><E><N><A><T><T><N><A><E><V><L><R><T><M><E><L><A><A><Q><S><M><K><K><A><Y><Q><D><M><D><I><D><K><V><D><E><L><M><T><D><I><T><E><Q><Q><E><V><A><Q><Q><I><S><D><A><I><S><R><P><M><G><F><G><D><D><V><D><E><D><E><L><L><E><E><L><E><E><L><E><Q><E><E><L><A><Q><E><L><L><N><V><G><D><K><E><E><E><P><S><V><K><L><P><S><V><P><S><T><H><L><P><A><G><P><A><P><K><V><D><E><D><E><E><A><L><K><Q><L><A><E><W><V><S>
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction
Q9BY43
P20933
ASPG_HUMAN
Glycosylasparaginase beta chain
Homo
<M><A><R><K><S><N><L><P><V><L><L><V><P><F><L><L><C><Q><A><L><V><R><C><S><S><P><L><P><L><V><V><N><T><W><P><F><K><N><A><T><E><A><A><W><R><A><L><A><S><G><G><S><A><L><D><A><V><E><S><G><C><A><M><C><E><R><E><Q><C><D><G><S><V><G><F><G><G><S><P><D><E><L><G><E><T><T><L><D><A><M><I><M><D><G><T><T><M><D><V><G><A><V><G><D><L><R><R><I><K><N><A><I><G><V><A><R><K><V><L><E><H><T><T><H><T><L><L><V><G><E><S><A><T><T><F><A><Q><S><M><G><F><I><N><E><D><L><S><T><T><A><S><Q><A><L><H><S><D><W><L><A><R><N><C><Q><P><N><Y><W><R><N><V><I><P><D><P><S><K><Y><C><G><P><Y><K><P><P><G><I><L><K><Q><D><I><P><I><H><K><E><T><E><D><D><R><G><H><D><T><I><G><M><V><V><I><H><K><T><G><H><I><A><A><G><T><S><T><N><G><I><K><F><K><I><H><G><R><V><G><D><S><P><I><P><G><A><G><A><Y><A><D><D><T><A><G><A><A><A><A><T><G><N><G><D><I><L><M><R><F><L><P><S><Y><Q><A><V><E><Y><M><R><R><G><E><D><P><T><I><A><C><Q><K><V><I><S><R><I><Q><K><H><F><P><E><F><F><G><A><V><I><C><A><N><V><T><G><S><Y><G><A><A><C><N><K><L><S><T><F><T><Q><F><S><F><M><V><Y><N><S><E><K><N><Q><P><T><E><E><K><V><D><C><I>
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.<BOP>
P20933
Q8NGI3
O56B1_HUMAN
Olfactory receptor OR11-65
Homo
<M><N><H><M><S><A><S><L><K><I><S><N><S><S><K><F><Q><V><S><E><F><I><L><L><G><F><P><G><I><H><S><W><Q><H><W><L><S><L><P><L><A><L><L><Y><L><S><A><L><A><A><N><T><L><I><L><I><I><I><W><Q><N><P><S><L><Q><Q><P><M><Y><I><F><L><G><I><L><C><M><V><D><M><G><L><A><T><T><I><I><P><K><I><L><A><I><F><W><F><D><A><K><V><I><S><L><P><E><C><F><A><Q><I><Y><A><I><H><F><F><V><G><M><E><S><G><I><L><L><C><M><A><F><D><R><Y><V><A><I><C><H><P><L><R><Y><P><S><I><V><T><S><S><L><I><L><K><A><T><L><F><M><V><L><R><N><G><L><F><V><T><P><V><P><V><L><A><A><Q><R><D><Y><C><S><K><N><E><I><E><H><C><L><C><S><N><L><G><V><T><S><L><A><C><D><D><R><R><P><N><S><I><C><Q><L><V><L><A><W><L><G><M><G><S><D><L><S><L><I><I><L><S><Y><I><L><I><L><Y><S><V><L><R><L><N><S><A><E><A><A><A><K><A><L><S><T><C><S><S><H><L><T><L><I><L><F><F><Y><T><I><V><V><V><I><S><V><T><H><L><T><E><M><K><A><T><L><I><P><V><L><L><N><V><L><H><N><I><I><P><P><S><L><N><P><T><V><Y><A><L><Q><T><K><E><L><R><A><A><F><Q><K><V><L><F><A><L><T><K><E><I><R><S>
Odorant receptor.<BOP>
Q8NGI3
Q8WV83
S35F5_HUMAN
Hepatitis C virus NS5A-transactivated protein 3
Homo
<M><V><P><P><R><R><H><R><G><A><G><R><P><G><V><L><S><S><S><P><P><F><R><L><R><S><A><K><F><S><G><I><A><L><E><D><L><R><R><A><L><K><T><R><L><Q><M><V><C><V><F><V><M><N><R><M><N><S><Q><N><S><G><F><T><Q><R><R><R><M><A><L><G><I><V><I><L><L><L><V><D><V><I><W><V><A><S><S><E><L><T><S><Y><V><F><T><Q><Y><N><K><P><F><F><S><T><F><A><K><T><S><M><F><V><L><Y><L><L><G><F><I><I><W><K><P><W><R><Q><Q><C><T><R><G><L><R><G><K><H><A><A><F><F><A><D><A><E><G><Y><F><A><A><C><T><T><D><T><T><M><N><S><S><L><S><E><P><L><Y><V><P><V><K><F><H><D><L><P><S><E><K><P><E><S><T><N><I><D><T><E><K><T><P><K><K><S><R><V><R><F><S><N><I><M><E><I><R><Q><L><P><S><S><H><A><L><E><A><K><L><S><R><M><S><Y><P><V><K><E><Q><E><S><I><L><K><T><V><G><K><L><T><A><T><Q><V><A><K><I><S><F><F><F><C><F><V><W><F><L><A><N><L><S><Y><Q><E><A><L><S><D><T><Q><V><A><I><V><N><I><L><S><S><T><S><G><L><F><T><L><I><L><A><A><V><F><P><S><N><S><G><D><R><F><T><L><S><K><L><L><A><V><I><L><S><I><G><G><V><V><L><V><N><L><A><G><S><E><K><P><A><G><R><D><T><V><G><S><I><W><S><L><A><G><A><M><L><Y><A><V><Y><I><V><M><I><K><R><K><V><D><R><E><D><K><L><D><I><P><M><F><F><G><F><V><G><L><F><N><L><L><L><L><W><P><G><F><F><L><L><H><Y><T><G><F><E><D><F><E><F><P><N><K><V><V><L><M><C><I><I><I><N><G><L><I><G><T><V><L><S><E><F><L><W><L><W><G><C><F><L><T><S><S><L><I><G><T><L><A><L><S><L><T><I><P><L><S><I><I><A><D><M><C><M><Q><K><V><Q><F><S><W><L><F><F><A><G><A><I><P><V><F><F><S><F><F><I><V><T><L><L><C><H><Y><N><N><W><D><P><V><M><V><G><I><R><R><I><F><A><F><I><C><R><K><H><R><I><Q><R><V><P><E><D><S><E><Q><C><E><S><L><I><S><M><H><S><V><S><Q><E><D><G><A><S>
Putative solute transporter.<BOP>
Q8WV83
Q9Y5Y2
NUBP2_HUMAN
Nucleotide-binding protein 2
Homo
<M><E><A><A><A><E><P><G><N><L><A><G><V><R><H><I><I><L><V><L><S><G><K><G><G><V><G><K><S><T><I><S><T><E><L><A><L><A><L><R><H><A><G><K><K><V><G><I><L><D><V><D><L><C><G><P><S><I><P><R><M><L><G><A><Q><G><R><A><V><H><Q><C><D><R><G><W><A><P><V><F><L><D><R><E><Q><S><I><S><L><M><S><V><G><F><L><L><E><K><P><D><E><A><V><V><W><R><G><P><K><K><N><A><L><I><K><Q><F><V><S><D><V><A><W><G><E><L><D><Y><L><V><V><D><T><P><P><G><T><S><D><E><H><M><A><T><I><E><A><L><R><P><Y><Q><P><L><G><A><L><V><V><T><T><P><Q><A><V><S><V><G><D><V><R><R><E><L><T><F><C><R><K><T><G><L><R><V><M><G><I><V><E><N><M><S><G><F><T><C><P><H><C><T><E><C><T><S><V><F><S><R><G><G><G><E><E><L><A><Q><L><A><G><V><P><F><L><G><S><V><P><L><D><P><A><L><M><R><T><L><E><E><G><H><D><F><I><Q><E><F><P><G><S><P><A><F><A><A><L><T><S><I><A><Q><K><I><L><D><A><T><P><A><C><L><P>
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.<BOP>
Q9Y5Y2
A0A0B4J1V0
HV315_HUMAN
Immunoglobulin heavy variable 3-15
Homo
<M><E><F><G><L><S><W><I><F><L><A><A><I><L><K><G><V><Q><C><E><V><Q><L><V><E><S><G><G><G><L><V><K><P><G><G><S><L><R><L><S><C><A><A><S><G><F><T><F><S><N><A><W><M><S><W><V><R><Q><A><P><G><K><G><L><E><W><V><G><R><I><K><S><K><T><D><G><G><T><T><D><Y><A><A><P><V><K><G><R><F><T><I><S><R><D><D><S><K><N><T><L><Y><L><Q><M><N><S><L><K><T><E><D><T><A><V><Y><Y><C><T><T>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A0B4J1V0
Q9H967
WDR76_HUMAN
WD repeat-containing protein 76
Homo
<M><S><R><S><G><A><A><A><E><K><A><D><S><R><Q><R><P><Q><M><K><V><N><E><Y><K><E><N><Q><N><I><A><Y><V><S><L><R><P><A><Q><T><T><V><L><I><K><T><A><K><V><Y><L><A><P><F><S><L><S><N><Y><Q><L><D><Q><L><M><C><P><K><S><L><S><E><K><N><S><N><N><E><V><A><C><K><K><T><K><I><K><K><T><C><R><R><I><I><P><P><K><M><K><N><T><S><S><K><A><E><S><T><L><Q><N><S><S><S><A><V><H><T><E><S><N><K><L><Q><P><K><R><T><A><D><A><M><N><L><S><V><D><V><E><S><S><Q><D><G><D><S><D><E><D><T><T><P><S><L><D><F><S><G><L><S><P><Y><E><R><K><R><L><K><N><I><S><E><N><A><D><F><F><A><S><L><Q><L><S><E><S><A><A><R><L><R><E><M><I><E><K><R><Q><P><P><K><S><K><R><K><K><P><K><R><E><N><G><I><G><C><R><R><S><M><R><L><L><K><V><D><P><S><G><V><S><L><P><A><A><P><T><P><P><T><L><V><A><D><E><T><P><L><L><P><P><G><P><L><E><M><T><S><E><N><Q><E><D><N><N><E><R><F><K><G><F><L><H><T><W><A><G><M><S><K><P><S><S><K><N><T><E><K><G><L><S><S><I><K><S><Y><K><A><N><L><N><G><M><V><I><S><E><D><T><V><Y><K><V><T><T><G><P><I><F><S><M><A><L><H><P><S><E><T><R><T><L><V><A><V><G><A><K><F><G><Q><V><G><L><C><D><L><T><Q><Q><P><K><E><D><G><V><Y><V><F><H><P><H><S><Q><P><V><S><C><L><Y><F><S><P><A><N><P><A><H><I><L><S><L><S><Y><D><G><T><L><R><C><G><D><F><S><R><A><I><F><E><E><V><Y><R><N><E><R><S><S><F><S><S><F><D><F><L><A><E><D><A><S><T><L><I><V><G><H><W><D><G><N><M><S><L><V><D><R><R><T><P><G><T><S><Y><E><K><L><T><S><S><S><M><G><K><I><R><T><V><H><V><H><P><V><H><R><Q><Y><F><I><T><A><G><L><R><D><T><H><I><Y><D><A><R><R><L><N><S><R><R><S><Q><P><L><I><S><L><T><E><H><T><K><S><I><A><S><A><Y><F><S><P><L><T><G><N><R><V><V><T><T><C><A><D><C><N><L><R><I><F><D><S><S><C><I><S><S><K><I><P><L><L><T><T><I><R><H><N><T><F><T><G><R><W><L><T><R><F><Q><A><M><W><D><P><K><Q><E><D><C><V><I><V><G><S><M><A><H><P><R><R><V><E><I><F><H><E><T><G><K><R><V><H><S><F><G><G><E><Y><L><V><S><V><C><S><I><N><A><M><H><P><T><R><Y><I><L><A><G><G><N><S><S><G><K><I><H><V><F><M><N><E><K><S><C>
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.<BOP>
Q9H967
P00966
ASSY_HUMAN
Citrulline--aspartate ligase
Homo
<M><S><S><K><G><S><V><V><L><A><Y><S><G><G><L><D><T><S><C><I><L><V><W><L><K><E><Q><G><Y><D><V><I><A><Y><L><A><N><I><G><Q><K><E><D><F><E><E><A><R><K><K><A><L><K><L><G><A><K><K><V><F><I><E><D><V><S><R><E><F><V><E><E><F><I><W><P><A><I><Q><S><S><A><L><Y><E><D><R><Y><L><L><G><T><S><L><A><R><P><C><I><A><R><K><Q><V><E><I><A><Q><R><E><G><A><K><Y><V><S><H><G><A><T><G><K><G><N><D><Q><V><R><F><E><L><S><C><Y><S><L><A><P><Q><I><K><V><I><A><P><W><R><M><P><E><F><Y><N><R><F><K><G><R><N><D><L><M><E><Y><A><K><Q><H><G><I><P><I><P><V><T><P><K><N><P><W><S><M><D><E><N><L><M><H><I><S><Y><E><A><G><I><L><E><N><P><K><N><Q><A><P><P><G><L><Y><T><K><T><Q><D><P><A><K><A><P><N><T><P><D><I><L><E><I><E><F><K><K><G><V><P><V><K><V><T><N><V><K><D><G><T><T><H><Q><T><S><L><E><L><F><M><Y><L><N><E><V><A><G><K><H><G><V><G><R><I><D><I><V><E><N><R><F><I><G><M><K><S><R><G><I><Y><E><T><P><A><G><T><I><L><Y><H><A><H><L><D><I><E><A><F><T><M><D><R><E><V><R><K><I><K><Q><G><L><G><L><K><F><A><E><L><V><Y><T><G><F><W><H><S><P><E><C><E><F><V><R><H><C><I><A><K><S><Q><E><R><V><E><G><K><V><Q><V><S><V><L><K><G><Q><V><Y><I><L><G><R><E><S><P><L><S><L><Y><N><E><E><L><V><S><M><N><V><Q><G><D><Y><E><P><T><D><A><T><G><F><I><N><I><N><S><L><R><L><K><E><Y><H><R><L><Q><S><K><V><T><A><K>
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.<BOP>
P00966
Q07955
SRSF1_HUMAN
pre-mRNA-splicing factor SF2, P33 subunit
Homo
<M><S><G><G><G><V><I><R><G><P><A><G><N><N><D><C><R><I><Y><V><G><N><L><P><P><D><I><R><T><K><D><I><E><D><V><F><Y><K><Y><G><A><I><R><D><I><D><L><K><N><R><R><G><G><P><P><F><A><F><V><E><F><E><D><P><R><D><A><E><D><A><V><Y><G><R><D><G><Y><D><Y><D><G><Y><R><L><R><V><E><F><P><R><S><G><R><G><T><G><R><G><G><G><G><G><G><G><G><G><A><P><R><G><R><Y><G><P><P><S><R><R><S><E><N><R><V><V><V><S><G><L><P><P><S><G><S><W><Q><D><L><K><D><H><M><R><E><A><G><D><V><C><Y><A><D><V><Y><R><D><G><T><G><V><V><E><F><V><R><K><E><D><M><T><Y><A><V><R><K><L><D><N><T><K><F><R><S><H><E><G><E><T><A><Y><I><R><V><K><V><D><G><P><R><S><P><S><Y><G><R><S><R><S><R><S><R><S><R><S><R><S><R><S><R><S><N><S><R><S><R><S><Y><S><P><R><R><S><R><G><S><P><R><Y><S><P><R><H><S><R><S><R><S><R><T>
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.<BOP>
Q07955
Q4G0S4
C27C1_HUMAN
All-trans retinol 3,4-desaturase
Homo
<M><Q><T><S><A><M><A><L><L><A><R><I><L><R><A><G><L><R><P><A><P><E><R><G><G><L><L><G><G><G><A><P><R><R><P><Q><P><A><G><A><R><L><P><A><G><A><R><A><E><D><K><G><A><G><R><P><G><S><P><P><G><G><G><R><A><E><G><P><R><S><L><A><A><M><P><G><P><R><T><L><A><N><L><A><E><F><F><C><R><D><G><F><S><R><I><H><E><I><Q><Q><K><H><T><R><E><Y><G><K><I><F><K><S><H><F><G><P><Q><F><V><V><S><I><A><D><R><D><M><V><A><Q><V><L><R><A><E><G><A><A><P><Q><R><A><N><M><E><S><W><R><E><Y><R><D><L><R><G><R><A><T><G><L><I><S><A><E><G><E><Q><W><L><K><M><R><S><V><L><R><Q><R><I><L><K><P><K><D><V><A><I><Y><S><G><E><V><N><Q><V><I><A><D><L><I><K><R><I><Y><L><L><R><S><Q><A><E><D><G><E><T><V><T><N><V><N><D><L><F><F><K><Y><S><M><E><G><V><A><T><I><L><Y><E><S><R><L><G><C><L><E><N><S><I><P><Q><L><T><V><E><Y><I><E><A><L><E><L><M><F><S><M><F><K><T><S><M><Y><A><G><A><I><P><R><W><L><R><P><F><I><P><K><P><W><R><E><F><C><R><S><W><D><G><L><F><K><F><S><Q><I><H><V><D><N><K><L><R><D><I><Q><Y><Q><M><D><R><G><R><R><V><S><G><G><L><L><T><Y><L><F><L><S><Q><A><L><T><L><Q><E><I><Y><A><N><V><T><E><M><L><L><A><G><V><D><T><T><S><F><T><L><S><W><T><V><Y><L><L><A><R><H><P><E><V><Q><Q><T><V><Y><R><E><I><V><K><N><L><G><E><R><H><V><P><T><A><A><D><V><P><K><V><P><L><V><R><A><L><L><K><E><T><L><R><L><F><P><V><L><P><G><N><G><R><V><T><Q><E><D><L><V><I><G><G><Y><L><I><P><K><G><T><Q><L><A><L><C><H><Y><A><T><S><Y><Q><D><E><N><F><P><R><A><K><E><F><R><P><E><R><W><L><R><K><G><D><L><D><R><V><D><N><F><G><S><I><P><F><G><H><G><V><R><S><C><I><G><R><R><I><A><E><L><E><I><H><L><V><V><I><Q><L><L><Q><H><F><E><I><K><T><S><S><Q><T><N><A><V><H><A><K><T><H><G><L><L><T><P><G><G><P><I><H><V><R><F><V><N><R><K>
A cytochrome P450 monooxygenase that catalyzes the 3,4 desaturation of all-trans-retinol (also called vitamin A1) to all-trans-3,4-didehydroretinol (also called vitamin A2) in the skin. Desaturates with lower efficiency all-trans retinal and all-trans retinoic acid. Forms minor amounts of 3-hydroxy and 4-hydroxy all-trans-retinol derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).<BOP>
Q4G0S4
Q9H3Y8
PPDPF_HUMAN
Exocrine differentiation and proliferation factor
Homo
<M><A><A><I><P><S><S><G><S><L><V><A><T><H><D><Y><Y><R><R><R><L><G><S><T><S><S><N><S><S><C><S><S><T><E><C><P><G><E><A><I><P><H><P><P><G><L><P><K><A><D><P><G><H><W><W><A><S><F><F><F><G><K><S><T><L><P><F><M><A><T><V><L><E><S><A><E><H><S><E><P><P><Q><A><S><S><S><M><T><A><C><G><L><A><R><D><A><P><R><K><Q><P><G><G><Q><S><S><T><A><S><A><G><P><P><S>
Probable regulator of exocrine pancreas development.<BOP>
Q9H3Y8
Q8IVB4
SL9A9_HUMAN
Solute carrier family 9 member 9
Homo
<M><E><R><Q><S><R><V><M><S><E><K><D><E><Y><Q><F><Q><H><Q><G><A><V><E><L><L><V><F><N><F><L><L><I><L><T><I><L><T><I><W><L><F><K><N><H><R><F><R><F><L><H><E><T><G><G><A><M><V><Y><G><L><I><M><G><L><I><L><R><Y><A><T><A><P><T><D><I><E><S><G><T><V><Y><D><C><V><K><L><T><F><S><P><S><T><L><L><V><N><I><T><D><Q><V><Y><E><Y><K><Y><K><R><E><I><S><Q><H><N><I><N><P><H><Q><G><N><A><I><L><E><K><M><T><F><D><P><E><I><F><F><N><V><L><L><P><P><I><I><F><H><A><G><Y><S><L><K><K><R><H><F><F><Q><N><L><G><S><I><L><T><Y><A><F><L><G><T><A><I><S><C><I><V><I><G><L><I><M><Y><G><F><V><K><A><M><I><H><A><G><Q><L><K><N><G><D><F><H><F><T><D><C><L><F><F><G><S><L><M><S><A><T><D><P><V><T><V><L><A><I><F><H><E><L><H><V><D><P><D><L><Y><T><L><L><F><G><E><S><V><L><N><D><A><V><A><I><V><L><T><Y><S><I><S><I><Y><S><P><K><E><N><P><N><A><F><D><A><A><A><F><F><Q><S><V><G><N><F><L><G><I><F><A><G><S><F><A><M><G><S><A><Y><A><I><I><T><A><L><L><T><K><F><T><K><L><C><E><F><P><M><L><E><T><G><L><F><F><L><L><S><W><S><A><F><L><S><A><E><A><A><G><L><T><G><I><V><A><V><L><F><C><G><V><T><Q><A><H><Y><T><Y><N><N><L><S><S><D><S><K><I><R><T><K><Q><L><F><E><F><M><N><F><L><A><E><N><V><I><F><C><Y><M><G><L><A><L><F><T><F><Q><N><H><I><F><N><A><L><F><I><L><G><A><F><L><A><I><F><V><A><R><A><C><N><I><Y><P><L><S><F><L><L><N><L><G><R><K><Q><K><I><P><W><N><F><Q><H><M><M><M><F><S><G><L><R><G><A><I><A><F><A><L><A><I><R><N><T><E><S><Q><P><K><Q><M><M><F><T><T><T><L><L><L><V><F><F><T><V><W><V><F><G><G><G><T><T><P><M><L><T><W><L><Q><I><R><V><G><V><D><L><D><E><N><L><K><E><D><P><S><S><Q><H><Q><E><A><N><N><L><D><K><N><M><T><K><A><E><S><A><R><L><F><R><M><W><Y><S><F><D><H><K><Y><L><K><P><I><L><T><H><S><G><P><P><L><T><T><T><L><P><E><W><C><G><P><I><S><R><L><L><T><S><P><Q><A><Y><G><E><Q><L><K><E><D><D><V><E><C><I><V><N><Q><D><E><L><A><I><N><Y><Q><E><Q><A><S><S><P><C><S><P><P><A><R><L><G><L><D><Q><K><A><S><P><Q><T><P><G><K><E><N><I><Y><E><G><D><L><G><L><G><G><Y><E><L><K><L><E><Q><T><L><G><Q><S><Q><L><N>
May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.<BOP>
Q8IVB4
P13995
MTDC_HUMAN
Methenyltetrahydrofolate cyclohydrolase
Homo
<M><A><A><T><S><L><M><S><A><L><A><A><R><L><L><Q><P><A><H><S><C><S><L><R><L><R><P><F><H><L><A><A><V><R><N><E><A><V><V><I><S><G><R><K><L><A><Q><Q><I><K><Q><E><V><R><Q><E><V><E><E><W><V><A><S><G><N><K><R><P><H><L><S><V><I><L><V><G><E><N><P><A><S><H><S><Y><V><L><N><K><T><R><A><A><A><V><V><G><I><N><S><E><T><I><M><K><P><A><S><I><S><E><E><E><L><L><N><L><I><N><K><L><N><N><D><D><N><V><D><G><L><L><V><Q><L><P><L><P><E><H><I><D><E><R><R><I><C><N><A><V><S><P><D><K><D><V><D><G><F><H><V><I><N><V><G><R><M><C><L><D><Q><Y><S><M><L><P><A><T><P><W><G><V><W><E><I><I><K><R><T><G><I><P><T><L><G><K><N><V><V><V><A><G><R><S><K><N><V><G><M><P><I><A><M><L><L><H><T><D><G><A><H><E><R><P><G><G><D><A><T><V><T><I><S><H><R><Y><T><P><K><E><Q><L><K><K><H><T><I><L><A><D><I><V><I><S><A><A><G><I><P><N><L><I><T><A><D><M><I><K><E><G><A><A><V><I><D><V><G><I><N><R><V><H><D><P><V><T><A><K><P><K><L><V><G><D><V><D><F><E><G><V><R><Q><K><A><G><Y><I><T><P><V><P><G><G><V><G><P><M><T><V><A><M><L><M><K><N><T><I><I><A><A><K><K><V><L><R><L><E><E><R><E><V><L><K><S><K><E><L><G><V><A><T><N>
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.<BOP>
P13995
P31947
1433S_HUMAN
Stratifin
Homo
<M><E><R><A><S><L><I><Q><K><A><K><L><A><E><Q><A><E><R><Y><E><D><M><A><A><F><M><K><G><A><V><E><K><G><E><E><L><S><C><E><E><R><N><L><L><S><V><A><Y><K><N><V><V><G><G><Q><R><A><A><W><R><V><L><S><S><I><E><Q><K><S><N><E><E><G><S><E><E><K><G><P><E><V><R><E><Y><R><E><K><V><E><T><E><L><Q><G><V><C><D><T><V><L><G><L><L><D><S><H><L><I><K><E><A><G><D><A><E><S><R><V><F><Y><L><K><M><K><G><D><Y><Y><R><Y><L><A><E><V><A><T><G><D><D><K><K><R><I><I><D><S><A><R><S><A><Y><Q><E><A><M><D><I><S><K><K><E><M><P><P><T><N><P><I><R><L><G><L><A><L><N><F><S><V><F><H><Y><E><I><A><N><S><P><E><E><A><I><S><L><A><K><T><T><F><D><E><A><M><A><D><L><H><T><L><S><E><D><S><Y><K><D><S><T><L><I><M><Q><L><L><R><D><N><L><T><L><W><T><A><D><N><A><G><E><E><G><G><E><A><P><Q><E><P><Q><S>
p53-regulated inhibitor of G2/M progression.<BOP>
P31947
Q8NBB4
ZSCA1_HUMAN
Zinc finger and SCAN domain-containing protein 1
Homo
<M><L><P><R><P><K><A><P><A><S><P><R><R><P><Q><T><P><T><P><S><E><Q><D><A><D><P><G><P><A><S><P><R><D><T><E><A><Q><R><L><R><F><R><Q><F><Q><Y><H><V><A><S><G><P><H><L><A><L><G><Q><L><W><T><L><C><R><Q><W><L><R><P><E><A><R><S><K><E><Q><M><L><E><L><L><V><L><E><Q><F><L><G><A><L><P><S><K><M><R><T><W><V><Q><S><Q><G><P><R><S><C><R><E><A><A><S><L><V><E><D><L><T><Q><M><C><Q><Q><E><V><L><V><S><L><D><S><V><E><P><Q><D><W><S><F><G><E><E><E><D><G><K><S><P><R><S><Q><K><E><P><S><Q><A><S><E><L><I><L><D><A><V><A><A><A><P><A><L><P><E><E><S><E><W><L><E><T><T><Q><L><Q><Q><S><L><H><T><R><A><E><A><E><A><P><R><A><P><G><L><L><G><S><R><A><R><L><P><L><K><P><S><I><W><D><E><P><E><D><L><L><A><G><P><S><S><D><L><R><A><E><G><T><V><I><S><S><P><K><G><P><S><A><Q><R><I><S><P><R><R><R><N><R><N><T><D><Q><S><G><R><H><Q><P><S><L><K><H><T><K><G><G><T><Q><E><A><V><A><G><I><S><V><V><P><R><G><P><R><G><G><R><P><F><Q><C><A><D><C><G><M><V><F><T><W><V><T><H><F><I><E><H><Q><K><T><H><R><E><E><G><P><F><P><C><P><E><C><G><K><V><F><L><H><N><S><V><L><T><E><H><G><K><I><H><L><L><E><P><P><R><K><K><A><P><R><S><K><G><P><R><E><S><V><P><P><R><D><G><A><Q><G><P><V><A><P><R><S><P><K><R><P><F><Q><C><S><V><C><G><K><A><F><P><W><M><V><H><L><I><D><H><Q><K><L><H><T><A><H><G><H><M>
May be involved in transcriptional regulation.<BOP>
Q8NBB4
P36021
MOT8_HUMAN
X-linked PEST-containing transporter
Homo
<M><A><L><Q><S><Q><A><S><E><E><A><K><G><P><W><Q><E><A><D><Q><E><Q><Q><E><P><V><G><S><P><E><P><E><S><E><P><E><P><E><P><E><P><E><P><V><P><V><P><P><P><E><P><Q><P><E><P><Q><P><L><P><D><P><A><P><L><P><E><L><E><F><E><S><E><R><V><H><E><P><E><P><T><P><T><V><E><T><R><G><T><A><R><G><F><Q><P><P><E><G><G><F><G><W><V><V><V><F><A><A><T><W><C><N><G><S><I><F><G><I><H><N><S><V><G><I><L><Y><S><M><L><L><E><E><E><K><E><K><N><R><Q><V><E><F><Q><A><A><W><V><G><A><L><A><M><G><M><I><F><F><C><S><P><I><V><S><I><F><T><D><R><L><G><C><R><I><T><A><T><A><G><A><A><V><A><F><I><G><L><H><T><S><S><F><T><S><S><L><S><L><R><Y><F><T><Y><G><I><L><F><G><C><G><C><S><F><A><F><Q><P><S><L><V><I><L><G><H><Y><F><Q><R><R><L><G><L><A><N><G><V><V><S><A><G><S><S><I><F><S><M><S><F><P><F><L><I><R><M><L><G><D><K><I><K><L><A><Q><T><F><Q><V><L><S><T><F><M><F><V><L><M><L><L><S><L><T><Y><R><P><L><L><P><S><S><Q><D><T><P><S><K><R><G><V><R><T><L><H><Q><R><F><L><A><Q><L><R><K><Y><F><N><M><R><V><F><R><Q><R><T><Y><R><I><W><A><F><G><I><A><A><A><A><L><G><Y><F><V><P><Y><V><H><L><M><K><Y><V><E><E><E><F><S><E><I><K><E><T><W><V><L><L><V><C><I><G><A><T><S><G><L><G><R><L><V><S><G><H><I><S><D><S><I><P><G><L><K><K><I><Y><L><Q><V><L><S><F><L><L><L><G><L><M><S><M><M><I><P><L><C><R><D><F><G><G><L><I><V><V><C><L><F><L><G><L><C><D><G><F><F><I><T><I><M><A><P><I><A><F><E><L><V><G><P><M><Q><A><S><Q><A><I><G><Y><L><L><G><M><M><A><L><P><M><I><A><G><P><P><I><A><G><L><L><R><N><C><F><G><D><Y><H><V><A><F><Y><F><A><G><V><P><P><I><I><G><A><V><I><L><F><F><V><P><L><M><H><Q><R><M><F><K><K><E><Q><R><D><S><S><K><D><K><M><L><A><P><D><P><D><P><N><G><E><L><L><P><G><S><P><N><P><E><E><P><I>
Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) . Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) .<BOP>
P36021
Q9H596
DUS21_HUMAN
Low molecular weight dual specificity phosphatase 21
Homo
<M><T><A><S><A><S><S><F><S><S><S><Q><G><V><Q><Q><P><S><I><Y><S><F><S><Q><I><T><R><S><L><F><L><S><N><G><V><A><A><N><D><K><L><L><L><S><S><N><R><I><T><A><I><V><N><A><S><V><E><V><V><N><V><F><F><E><G><I><Q><Y><I><K><V><P><V><T><D><A><R><D><S><R><L><Y><D><F><F><D><P><I><A><D><L><I><H><T><I><D><M><R><Q><G><R><T><L><L><H><C><M><A><G><V><S><R><S><A><S><L><C><L><A><Y><L><M><K><Y><H><S><M><S><L><L><D><A><H><T><W><T><K><S><R><R><P><I><I><R><P><N><N><G><F><W><E><Q><L><I><N><Y><E><F><K><L><F><N><N><N><T><V><R><M><I><N><S><P><V><G><N><I><P><D><I><Y><E><K><D><L><R><M><M><I><S><M>
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine.<BOP>
Q9H596
Q7Z5H5
VN1R4_HUMAN
V1r-like receptor 4
Homo
<M><A><S><R><Y><V><A><V><G><M><I><L><S><Q><T><V><V><G><V><L><G><S><F><S><V><L><L><H><Y><L><S><F><Y><C><T><G><C><R><L><R><S><T><D><L><I><V><K><H><L><I><V><A><N><F><L><A><L><R><C><K><G><V><P><Q><T><M><A><A><F><G><V><R><Y><F><L><N><A><L><G><C><K><L><V><F><Y><L><H><R><V><G><R><G><V><S><I><G><T><T><C><L><L><S><V><F><Q><V><I><T><V><S><S><R><K><S><R><W><A><K><L><K><E><K><A><P><K><H><V><G><F><S><V><L><L><C><W><I><V><C><M><L><V><N><I><I><F><P><M><Y><V><T><G><K><W><N><Y><T><N><I><T><V><N><E><D><L><G><Y><C><S><G><G><G><N><N><K><I><A><Q><T><L><R><A><M><L><L><S><F><P><D><V><L><C><L><G><L><M><L><W><V><S><S><S><M><V><C><I><L><H><R><H><K><Q><R><V><Q><H><I><D><R><S><D><L><S><P><R><A><S><P><E><N><R><A><T><Q><S><I><L><I><L><V><S><T><F><V><S><S><Y><T><L><S><C><L><F><Q><V><C><M><A><L><L><D><N><P><N><S><L><L><V><N><T><S><A><L><M><S><V><C><F><P><T><L><S><P><F><V><L><M><S><C><D><P><S><V><Y><R><F><C><F><A><W><K><R>
Putative pheromone receptor.<BOP>
Q7Z5H5
Q5VXT5
SYPL2_HUMAN
Synaptophysin-like protein 2
Homo
<M><S><S><T><E><S><A><G><R><T><A><D><K><S><P><R><Q><Q><V><D><R><L><L><V><G><L><R><W><R><R><L><E><E><P><L><G><F><I><K><V><L><Q><W><L><F><A><I><F><A><F><G><S><C><G><S><Y><S><G><E><T><G><A><M><V><R><C><N><N><E><A><K><D><V><S><S><I><I><V><A><F><G><Y><P><F><R><L><H><R><I><Q><Y><E><M><P><L><C><D><E><E><S><S><S><K><T><M><H><L><M><G><D><F><S><A><P><A><E><F><F><V><T><L><G><I><F><S><F><F><Y><T><M><A><A><L><V><I><Y><L><R><F><H><N><L><Y><T><E><N><K><R><F><P><L><V><D><F><C><V><T><V><S><F><T><F><F><W><L><V><A><A><A><A><W><G><K><G><L><T><D><V><K><G><A><T><R><P><S><S><L><T><A><A><M><S><V><C><H><G><E><E><A><V><C><S><A><G><A><T><P><S><M><G><L><A><N><I><S><V><L><F><G><F><I><N><F><F><L><W><A><G><N><C><W><F><V><F><K><E><T><P><W><H><G><Q><G><Q><G><Q><D><Q><D><Q><D><Q><D><Q><G><Q><G><P><S><Q><E><S><A><A><E><Q><G><A><V><E><K><Q>
Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.<BOP>
Q5VXT5
Q8N6L0
KASH5_HUMAN
KASH domain-containing protein 5
Homo
<M><D><L><P><E><G><P><V><G><G><P><T><A><E><M><Y><L><R><E><R><P><E><E><A><R><L><G><M><P><V><S><L><E><E><Q><I><L><N><S><T><F><E><A><C><D><P><Q><R><T><G><T><V><A><V><A><Q><V><L><A><Y><L><E><A><V><T><G><Q><G><P><Q><D><A><R><L><Q><T><L><A><N><S><L><D><P><N><G><E><G><P><K><A><T><V><D><L><D><T><F><L><V><V><M><R><D><W><I><A><A><C><Q><L><H><G><G><L><E><L><E><E><E><T><A><F><Q><G><A><L><T><S><R><Q><L><P><S><G><C><P><E><A><E><E><P><A><N><L><E><S><F><G><G><E><D><P><R><P><E><L><Q><A><T><A><D><L><L><S><S><L><E><D><L><E><L><S><N><R><R><L><V><G><E><N><A><K><L><Q><R><S><M><E><T><A><E><E><G><S><A><R><L><G><E><E><I><L><A><L><R><K><Q><L><H><S><T><Q><Q><A><L><Q><F><A><K><A><M><D><E><E><L><E><D><L><K><T><L><A><R><S><L><E><E><Q><N><R><S><L><L><A><Q><A><R><Q><A><E><K><E><Q><Q><H><L><V><A><E><M><E><T><L><Q><E><E><N><G><K><L><L><A><E><R><D><G><V><K><K><R><S><Q><E><L><A><M><E><K><D><T><L><K><R><Q><L><F><E><C><E><H><L><I><C><Q><R><D><T><I><L><S><E><R><T><R><D><V><E><S><L><A><Q><T><L><E><E><Y><R><V><T><T><Q><E><L><R><L><E><I><S><R><L><E><E><Q><L><S><Q><T><Y><E><G><P><D><E><L><P><E><G><A><Q><L><R><R><V><G><W><T><E><L><L><P><P><S><L><G><L><E><I><E><A><I><R><Q><K><Q><E><V><A><T><A><D><L><S><N><P><L><C><G><V><W><Q><W><E><E><V><I><H><E><T><S><E><E><T><E><F><P><S><E><A><P><A><G><G><Q><R><N><F><Q><G><E><P><A><H><P><E><E><G><R><K><E><P><S><M><W><L><T><R><R><E><E><E><E><D><A><E><S><Q><V><T><A><D><L><P><V><P><L><G><A><P><R><P><G><D><I><P><E><N><P><P><E><R><P><A><R><R><E><L><Q><Q><A><L><V><P><V><M><K><K><L><V><P><V><R><R><R><A><W><G><Q><L><C><L><P><P><Q><R><L><R><V><T><R><H><P><L><I><P><A><P><V><L><G><L><L><L><L><L><L><L><S><V><L><L><L><G><P><S><P><P><P><T><W><P><H><L><Q><L><C><Y><L><Q><P><P><P><V>
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.<BOP>
Q8N6L0
Q6XE38
SG1D4_HUMAN
IFN-gamma-inducible secretoglobin
Homo
<M><R><L><S><V><C><L><L><M><V><S><L><A><L><C><C><Y><Q><A><H><A><L><V><C><P><A><V><A><S><E><I><T><V><F><L><F><L><S><D><A><A><V><N><L><Q><V><A><K><L><N><P><P><P><E><A><L><A><A><K><L><E><V><K><H><C><T><D><Q><I><S><F><K><K><R><L><S><L><K><K><S><W><W><K>
Seems to be involved in the regulation of chemotactic cell migration and invasion.<BOP>
Q6XE38
P18621
RL17_HUMAN
PD-1
Homo
<M><V><R><Y><S><L><D><P><E><N><P><T><K><S><C><K><S><R><G><S><N><L><R><V><H><F><K><N><T><R><E><T><A><Q><A><I><K><G><M><H><I><R><K><A><T><K><Y><L><K><D><V><T><L><Q><K><Q><C><V><P><F><R><R><Y><N><G><G><V><G><R><C><A><Q><A><K><Q><W><G><W><T><Q><G><R><W><P><K><K><S><A><E><F><L><L><H><M><L><K><N><A><E><S><N><A><E><L><K><G><L><D><V><D><S><L><V><I><E><H><I><Q><V><N><K><A><P><K><M><R><R><R><T><Y><R><A><H><G><R><I><N><P><Y><M><S><S><P><C><H><I><E><M><I><L><T><E><K><E><Q><I><V><P><K><P><E><E><E><V><A><Q><K><K><K><I><S><Q><K><K><L><K><K><Q><K><L><M><A><R><E>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP>
P18621
P00568
KAD1_HUMAN
Myokinase
Homo
<M><E><E><K><L><K><K><T><K><I><I><F><V><V><G><G><P><G><S><G><K><G><T><Q><C><E><K><I><V><Q><K><Y><G><Y><T><H><L><S><T><G><D><L><L><R><S><E><V><S><S><G><S><A><R><G><K><K><L><S><E><I><M><E><K><G><Q><L><V><P><L><E><T><V><L><D><M><L><R><D><A><M><V><A><K><V><N><T><S><K><G><F><L><I><D><G><Y><P><R><E><V><Q><Q><G><E><E><F><E><R><R><I><G><Q><P><T><L><L><L><Y><V><D><A><G><P><E><T><M><T><Q><R><L><L><K><R><G><E><T><S><G><R><V><D><D><N><E><E><T><I><K><K><R><L><E><T><Y><Y><K><A><T><E><P><V><I><A><F><Y><E><K><R><G><I><V><R><K><V><N><A><E><G><S><V><D><S><V><F><S><Q><V><C><T><H><L><D><A><L><K>
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.<BOP>
P00568
Q9ULV8
CBLC_HUMAN
Signal transduction protein CBL-C
Homo
<M><A><L><A><V><A><P><W><G><R><Q><W><E><E><A><R><A><L><G><R><A><V><R><M><L><Q><R><L><E><E><Q><C><V><D><P><R><L><S><V><S><P><P><S><L><R><D><L><L><P><R><T><A><Q><L><L><R><E><V><A><H><S><R><R><A><A><G><G><G><G><P><G><G><P><G><G><S><G><D><F><L><L><I><Y><L><A><N><L><E><A><K><S><R><Q><V><A><A><L><L><P><P><R><G><R><R><S><A><N><D><E><L><F><R><A><G><S><R><L><R><R><Q><L><A><K><L><A><I><I><F><S><H><M><H><A><E><L><H><A><L><F><P><G><G><K><Y><C><G><H><M><Y><Q><L><T><K><A><P><A><H><T><F><W><R><E><S><C><G><A><R><C><V><L><P><W><A><E><F><E><S><L><L><G><T><C><H><P><V><E><P><G><C><T><A><L><A><L><R><T><T><I><D><L><T><C><S><G><H><V><S><I><F><E><F><D><V><F><T><R><L><F><Q><P><W><P><T><L><L><K><N><W><Q><L><L><A><V><N><H><P><G><Y><M><A><F><L><T><Y><D><E><V><Q><E><R><L><Q><A><C><R><D><K><P><G><S><Y><I><F><R><P><S><C><T><R><L><G><Q><W><A><I><G><Y><V><S><S><D><G><S><I><L><Q><T><I><P><A><N><K><P><L><S><Q><V><L><L><E><G><Q><K><D><G><F><Y><L><Y><P><D><G><K><T><H><N><P><D><L><T><E><L><G><Q><A><E><P><Q><Q><R><I><H><V><S><E><E><Q><L><Q><L><Y><W><A><M><D><S><T><F><E><L><C><K><I><C><A><E><S><N><K><D><V><K><I><E><P><C><G><H><L><L><C><S><C><C><L><A><A><W><Q><H><S><D><S><Q><T><C><P><F><C><R><C><E><I><K><G><W><E><A><V><S><I><Y><Q><F><H><G><Q><A><T><A><E><D><S><G><N><S><S><D><Q><E><G><R><E><L><E><L><G><Q><V><P><L><S><A><P><P><L><P><P><R><P><D><L><P><P><R><K><P><R><N><A><Q><P><K><V><R><L><L><K><G><N><S><P><P><A><A><L><G><P><Q><D><P><A><P><A>
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.<BOP>
Q9ULV8
Q6IMI6
ST1C3_HUMAN
Sulfotransferase 1C3
Homo
<M><A><K><I><E><K><N><A><P><T><M><E><K><K><P><E><L><F><N><I><M><E><V><D><G><V><P><T><L><I><L><S><K><E><W><W><E><K><V><C><N><F><Q><A><K><P><D><D><L><I><L><A><T><Y><P><K><S><G><T><T><W><M><H><E><I><L><D><M><I><L><N><D><G><D><V><E><K><C><K><R><A><Q><T><L><D><R><H><A><F><L><E><L><K><F><P><H><K><E><K><P><D><L><E><F><V><L><E><M><S><S><P><Q><L><I><K><T><H><L><P><S><H><L><I><P><P><S><I><W><K><E><N><C><K><I><V><Y><V><A><R><N><P><K><D><C><L><V><S><Y><Y><H><F><H><R><M><A><S><F><M><P><D><P><Q><N><L><E><E><F><Y><E><K><F><M><S><G><K><V><V><G><G><S><W><F><D><H><V><K><G><W><W><A><A><K><D><M><H><R><I><L><Y><L><F><Y><E><D><I><K><K><D><P><K><R><E><I><E><K><I><L><K><F><L><E><K><D><I><S><E><E><I><L><N><K><I><I><Y><H><T><S><F><D><V><M><K><Q><N><P><M><T><N><Y><T><T><L><P><T><S><I><M><D><H><S><I><S><P><F><M><R><K><G><M><P><G><D><W><K><N><Y><F><T><V><A><Q><N><E><E><F><D><K><D><Y><Q><K><K><M><A><G><S><T><L><T><F><R><T><E><I>
Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol).<BOP>
Q6IMI6
Q8WVI7
PPR1C_HUMAN
Inhibitor-5 of protein phosphatase 1
Homo
<M><E><P><N><S><P><K><K><I><Q><F><A><V><P><V><F><Q><S><Q><I><A><P><E><A><A><E><Q><I><R><K><R><R><P><T><P><A><S><L><V><I><L><N><E><H><N><P><P><E><I><D><D><K><R><G><P><N><T><Q><G><E><L><Q><N><A><S><P><K><Q><R><K><Q><S><V><Y><T><P><P><T><I><K><G><V><K><H><L><K><G><Q><N><E><S><A><F><P><E><E><E><E><G><T><N><E><R><E><E><Q><R><D><H>
May increase cell susceptibility to TNF-induced apoptosis.<BOP>
Q8WVI7
Q96A47
ISL2_HUMAN
Insulin gene enhancer protein ISL-2
Homo
<M><V><D><I><I><F><H><Y><P><F><L><G><A><M><G><D><H><S><K><K><K><P><G><T><A><M><C><V><G><C><G><S><Q><I><H><D><Q><F><I><L><R><V><S><P><D><L><E><W><H><A><A><C><L><K><C><A><E><C><S><Q><Y><L><D><E><T><C><T><C><F><V><R><D><G><K><T><Y><C><K><R><D><Y><V><R><L><F><G><I><K><C><A><K><C><Q><V><G><F><S><S><S><D><L><V><M><R><A><R><D><S><V><Y><H><I><E><C><F><R><C><S><V><C><S><R><Q><L><L><P><G><D><E><F><S><L><R><E><H><E><L><L><C><R><A><D><H><G><L><L><L><E><R><A><A><A><G><S><P><R><S><P><G><P><L><P><G><A><R><G><L><H><L><P><D><A><G><S><G><R><Q><P><A><L><R><P><H><V><H><K><Q><T><E><K><T><T><R><V><R><T><V><L><N><E><K><Q><L><H><T><L><R><T><C><Y><A><A><N><P><R><P><D><A><L><M><K><E><Q><L><V><E><M><T><G><L><S><P><R><V><I><R><V><W><F><Q><N><K><R><C><K><D><K><K><K><S><I><L><M><K><Q><L><Q><Q><Q><Q><H><S><D><K><T><S><L><Q><G><L><T><G><T><P><L><V><A><G><S><P><I><R><H><E><N><A><V><Q><G><S><A><V><E><V><Q><T><Y><Q><P><P><W><K><A><L><S><E><F><A><L><Q><S><D><L><D><Q><P><A><F><Q><Q><L><V><S><F><S><E><S><G><S><L><G><N><S><S><G><S><D><V><T><S><L><S><S><Q><L><P><D><T><P><N><S><M><V><P><S><P><V><E><T>
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.<BOP>
Q96A47
O60481
ZIC3_HUMAN
Zinc finger protein of the cerebellum 3
Homo
<M><T><M><L><L><D><G><G><P><Q><F><P><G><L><G><V><G><S><F><G><A><P><R><H><H><E><M><P><N><R><E><P><A><G><M><G><L><N><P><F><G><D><S><T><H><A><A><A><A><A><A><A><A><A><A><F><K><L><S><P><A><A><A><H><D><L><S><S><G><Q><S><S><A><F><T><P><Q><G><S><G><Y><A><N><A><L><G><H><H><H><H><H><H><H><H><H><H><H><T><S><Q><V><P><S><Y><G><G><A><A><S><A><A><F><N><S><T><R><E><F><L><F><R><Q><R><S><S><G><L><S><E><A><A><S><G><G><G><Q><H><G><L><F><A><G><S><A><S><S><L><H><A><P><A><G><I><P><E><P><P><S><Y><L><L><F><P><G><L><H><E><Q><G><A><G><H><P><S><P><T><G><H><V><D><N><N><Q><V><H><L><G><L><R><G><E><L><F><G><R><A><D><P><Y><R><P><V><A><S><P><R><T><D><P><Y><A><A><G><A><Q><F><P><N><Y><S><P><M><N><M><N><M><G><V><N><V><A><A><H><H><G><P><G><A><F><F><R><Y><M><R><Q><P><I><K><Q><E><L><S><C><K><W><I><D><E><A><Q><L><S><R><P><K><K><S><C><D><R><T><F><S><T><M><H><E><L><V><T><H><V><T><M><E><H><V><G><G><P><E><Q><N><N><H><V><C><Y><W><E><E><C><P><R><E><G><K><S><F><K><A><K><Y><K><L><V><N><H><I><R><V><H><T><G><E><K><P><F><P><C><P><F><P><G><C><G><K><I><F><A><R><S><E><N><L><K><I><H><K><R><T><H><T><G><E><K><P><F><K><C><E><F><E><G><C><D><R><R><F><A><N><S><S><D><R><K><K><H><M><H><V><H><T><S><D><K><P><Y><I><C><K><V><C><D><K><S><Y><T><H><P><S><S><L><R><K><H><M><K><V><H><E><S><Q><G><S><D><S><S><P><A><A><S><S><G><Y><E><S><S><T><P><P><A><I><A><S><A><N><S><K><D><T><T><K><T><P><S><A><V><Q><T><S><T><S><H><N><P><G><L><P><P><N><F><N><E><W><Y><V>
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.<BOP>
O60481
O00425
IF2B3_HUMAN
VICKZ family member 3
Homo
<M><N><K><L><Y><I><G><N><L><S><E><N><A><A><P><S><D><L><E><S><I><F><K><D><A><K><I><P><V><S><G><P><F><L><V><K><T><G><Y><A><F><V><D><C><P><D><E><S><W><A><L><K><A><I><E><A><L><S><G><K><I><E><L><H><G><K><P><I><E><V><E><H><S><V><P><K><R><Q><R><I><R><K><L><Q><I><R><N><I><P><P><H><L><Q><W><E><V><L><D><S><L><L><V><Q><Y><G><V><V><E><S><C><E><Q><V><N><T><D><S><E><T><A><V><V><N><V><T><Y><S><S><K><D><Q><A><R><Q><A><L><D><K><L><N><G><F><Q><L><E><N><F><T><L><K><V><A><Y><I><P><D><E><M><A><A><Q><Q><N><P><L><Q><Q><P><R><G><R><R><G><L><G><Q><R><G><S><S><R><Q><G><S><P><G><S><V><S><K><Q><K><P><C><D><L><P><L><R><L><L><V><P><T><Q><F><V><G><A><I><I><G><K><E><G><A><T><I><R><N><I><T><K><Q><T><Q><S><K><I><D><V><H><R><K><E><N><A><G><A><A><E><K><S><I><T><I><L><S><T><P><E><G><T><S><A><A><C><K><S><I><L><E><I><M><H><K><E><A><Q><D><I><K><F><T><E><E><I><P><L><K><I><L><A><H><N><N><F><V><G><R><L><I><G><K><E><G><R><N><L><K><K><I><E><Q><D><T><D><T><K><I><T><I><S><P><L><Q><E><L><T><L><Y><N><P><E><R><T><I><T><V><K><G><N><V><E><T><C><A><K><A><E><E><E><I><M><K><K><I><R><E><S><Y><E><N><D><I><A><S><M><N><L><Q><A><H><L><I><P><G><L><N><L><N><A><L><G><L><F><P><P><T><S><G><M><P><P><P><T><S><G><P><P><S><A><M><T><P><P><Y><P><Q><F><E><Q><S><E><T><E><T><V><H><L><F><I><P><A><L><S><V><G><A><I><I><G><K><Q><G><Q><H><I><K><Q><L><S><R><F><A><G><A><S><I><K><I><A><P><A><E><A><P><D><A><K><V><R><M><V><I><I><T><G><P><P><E><A><Q><F><K><A><Q><G><R><I><Y><G><K><I><K><E><E><N><F><V><S><P><K><E><E><V><K><L><E><A><H><I><R><V><P><S><F><A><A><G><R><V><I><G><K><G><G><K><T><V><N><E><L><Q><N><L><S><S><A><E><V><V><V><P><R><D><Q><T><P><D><E><N><D><Q><V><V><V><K><I><T><G><H><F><Y><A><C><Q><V><A><Q><R><K><I><Q><E><I><L><T><Q><V><K><Q><H><Q><Q><Q><K><A><L><Q><S><G><P><P><Q><S><R><R><K>
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability . Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD . Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<BOP>
O00425
Q9BYV6
TRI55_HUMAN
RING finger protein 29
Homo
<M><S><A><S><L><N><Y><K><S><F><S><K><E><Q><Q><T><M><D><N><L><E><K><Q><L><I><C><P><I><C><L><E><M><F><T><K><P><V><V><I><L><P><C><Q><H><N><L><C><R><K><C><A><S><D><I><F><Q><A><S><N><P><Y><L><P><T><R><G><G><T><T><M><A><S><G><G><R><F><R><C><P><S><C><R><H><E><V><V><L><D><R><H><G><V><Y><G><L><Q><R><N><L><L><V><E><N><I><I><D><I><Y><K><Q><E><S><T><R><P><E><K><K><S><D><Q><P><M><C><E><E><H><E><E><E><R><I><N><I><Y><C><L><N><C><E><V><P><T><C><S><L><C><K><V><F><G><A><H><K><D><C><Q><V><A><P><L><T><H><V><F><Q><R><Q><K><S><E><L><S><D><G><I><A><I><L><V><G><S><N><D><R><V><Q><G><V><I><S><Q><L><E><D><T><C><K><T><I><E><E><C><C><R><K><Q><K><Q><E><L><C><E><K><F><D><Y><L><Y><G><I><L><E><E><R><K><N><E><M><T><Q><V><I><T><R><T><Q><E><E><K><L><E><H><V><R><A><L><I><K><K><Y><S><D><H><L><E><N><V><S><K><L><V><E><S><G><I><Q><F><M><D><E><P><E><M><A><V><F><L><Q><N><A><K><T><L><L><K><K><I><S><E><A><S><K><A><F><Q><M><E><K><I><E><H><G><Y><E><N><M><N><H><F><T><V><N><L><N><R><E><E><K><I><I><R><E><I><D><F><Y><R><E><D><E><D><E><E><E><E><E><G><G><E><G><E><K><E><G><E><G><E><V><G><G><E><A><V><E><V><E><E><V><E><N><V><Q><T><E><F><P><G><E><D><E><N><P><E><K><A><S><E><L><S><Q><V><E><L><Q><A><A><P><G><A><L><P><V><S><S><P><E><P><P><P><A><L><P><P><A><A><D><A><P><V><T><Q><G><E><V><V><P><T><G><S><E><Q><T><T><E><S><E><T><P><V><P><A><A><A><E><T><A><D><P><L><F><Y><P><S><W><Y><K><G><Q><T><R><K><A><T><T><N><P><P><C><T><P><G><S><E><G><L><G><Q><I><G><P><P><G><S><E><D><S><N><V><R><K><A><E><V><A><A><A><A><A><S><E><R><A><A><V><S><G><K><E><T><S><A><P><A><A><T><S><Q><I><G><F><E><A><P><P><L><Q><G><Q><A><A><A><P><A><S><G><S><G><A><D><S><E><P><A><R><H><I><F><S><F><S><W><L><N><S><L><N><E>
May regulate gene expression and protein turnover in muscle cells.<BOP>
Q9BYV6
P17516
AK1C4_HUMAN
HAKRA
Homo
<M><D><P><K><Y><Q><R><V><E><L><N><D><G><H><F><M><P><V><L><G><F><G><T><Y><A><P><P><E><V><P><R><N><R><A><V><E><V><T><K><L><A><I><E><A><G><F><R><H><I><D><S><A><Y><L><Y><N><N><E><E><Q><V><G><L><A><I><R><S><K><I><A><D><G><S><V><K><R><E><D><I><F><Y><T><S><K><L><W><C><T><F><F><Q><P><Q><M><V><Q><P><A><L><E><S><S><L><K><K><L><Q><L><D><Y><V><D><L><Y><L><L><H><F><P><M><A><L><K><P><G><E><T><P><L><P><K><D><E><N><G><K><V><I><F><D><T><V><D><L><S><A><T><W><E><V><M><E><K><C><K><D><A><G><L><A><K><S><I><G><V><S><N><F><N><C><R><Q><L><E><M><I><L><N><K><P><G><L><K><Y><K><P><V><C><N><Q><V><E><C><H><P><Y><L><N><Q><S><K><L><L><D><F><C><K><S><K><D><I><V><L><V><A><H><S><A><L><G><T><Q><R><H><K><L><W><V><D><P><N><S><P><V><L><L><E><D><P><V><L><C><A><L><A><K><K><H><K><Q><T><P><A><L><I><A><L><R><Y><Q><L><Q><R><G><V><V><V><L><A><K><S><Y><N><E><Q><R><I><R><E><N><I><Q><V><F><E><F><Q><L><T><S><E><D><M><K><V><L><D><G><L><N><R><N><Y><R><Y><V><V><M><D><F><L><M><D><H><P><D><Y><P><F><S><D><E><Y>
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain . Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH . Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity . Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) . Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency . Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important
P17516
Q15027
ACAP1_HUMAN
Centaurin-beta-1
Homo
<M><T><V><K><L><D><F><E><E><C><L><K><D><S><P><R><F><R><A><S><I><E><L><V><E><A><E><V><S><E><L><E><T><R><L><E><K><L><L><K><L><G><T><G><L><L><E><S><G><R><H><Y><L><A><A><S><R><A><F><V><V><G><I><C><D><L><A><R><L><G><P><P><E><P><M><M><A><E><C><L><E><K><F><T><V><S><L><N><H><K><L><D><S><H><A><E><L><L><D><A><T><Q><H><T><L><Q><Q><Q><I><Q><T><L><V><K><E><G><L><R><G><F><R><E><A><R><R><D><F><W><R><G><A><E><S><L><E><A><A><L><T><H><N><A><E><V><P><R><R><R><A><Q><E><A><E><E><A><G><A><A><L><R><T><A><R><A><G><Y><R><G><R><A><L><D><Y><A><L><Q><I><N><V><I><E><D><K><R><K><F><D><I><M><E><F><V><L><R><L><V><E><A><Q><A><T><H><F><Q><Q><G><H><E><E><L><S><R><L><S><Q><Y><R><K><E><L><G><A><Q><L><H><Q><L><V><L><N><S><A><R><E><K><R><D><M><E><Q><R><H><V><L><L><K><Q><K><E><L><G><G><E><E><P><E><P><S><L><R><E><G><P><G><G><L><V><M><E><G><H><L><F><K><R><A><S><N><A><F><K><T><W><S><R><R><W><F><T><I><Q><S><N><Q><L><V><Y><Q><K><K><Y><K><D><P><V><T><V><V><V><D><D><L><R><L><C><T><V><K><L><C><P><D><S><E><R><R><F><C><F><E><V><V><S><T><S><K><S><C><L><L><Q><A><D><S><E><R><L><L><Q><L><W><V><S><A><V><Q><S><S><I><A><S><A><F><S><Q><A><R><L><D><D><S><P><R><G><P><G><Q><G><S><G><H><L><A><I><G><S><A><A><T><L><G><S><G><G><M><A><R><G><R><E><P><G><G><V><G><H><V><V><A><Q><V><Q><S><V><D><G><N><A><Q><C><C><D><C><R><E><P><A><P><E><W><A><S><I><N><L><G><V><T><L><C><I><Q><C><S><G><I><H><R><S><L><G><V><H><F><S><K><V><R><S><L><T><L><D><S><W><E><P><E><L><V><K><L><M><C><E><L><G><N><V><I><I><N><Q><I><Y><E><A><R><V><E><A><M><A><V><K><K><P><G><P><S><C><S><R><Q><E><K><E><A><W><I><H><A><K><Y><V><E><K><K><F><L><T><K><L><P><E><I><R><G><R><R><G><G><R><G><R><P><R><G><Q><P><P><V><P><P><K><P><S><I><R><P><R><P><G><S><L><R><S><K><P><E><P><P><S><E><D><L><G><S><L><H><P><G><A><L><L><F><R><A><S><G><H><P><P><S><L><P><T><M><A><D><A><L><A><H><G><A><D><V><N><W><V><N><G><G><Q><D><N><A><T><P><L><I><Q><A><T><A><A><N><S><L><L><A><C><E><F><L><L><Q><N><G><A><N><V><N><Q><A><D><S><A><G><R><G><P><L><H><H><A><T><I><L><G><H><T><G><L><A><C><L><F><L><K><R><G><A><D><L><G><A><R><D><S><E><G><R><D><P><L><T><I><A><M><E><T><A><N><A><D><I><V><T><L><L><R><L><A><K><M><R><E><A><E><A><A><Q><G><Q><A><G><D><E><T><Y><L><D><I><F><R><D><F><S><L><M><A><S><D><D><P><E><K><L><S><R><R><S><H><D><L><H><T><L>
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.<BOP>
Q15027
Q9UHX1
PUF60_HUMAN
Siah-binding protein 1
Homo
<M><A><T><A><T><I><A><L><Q><V><N><G><Q><Q><G><G><G><S><E><P><A><A><A><A><A><V><V><A><A><G><D><K><W><K><P><P><Q><G><T><D><S><I><K><M><E><N><G><Q><S><T><A><A><K><L><G><L><P><P><L><T><P><E><Q><Q><E><A><L><Q><K><A><K><K><Y><A><M><E><Q><S><I><K><S><V><L><V><K><Q><T><I><A><H><Q><Q><Q><Q><L><T><N><L><Q><M><A><A><V><T><M><G><F><G><D><P><L><S><P><L><Q><S><M><A><A><Q><R><Q><R><A><L><A><I><M><C><R><V><Y><V><G><S><I><Y><Y><E><L><G><E><D><T><I><R><Q><A><F><A><P><F><G><P><I><K><S><I><D><M><S><W><D><S><V><T><M><K><H><K><G><F><A><F><V><E><Y><E><V><P><E><A><A><Q><L><A><L><E><Q><M><N><S><V><M><L><G><G><R><N><I><K><V><G><R><P><S><N><I><G><Q><A><Q><P><I><I><D><Q><L><A><E><E><A><R><A><F><N><R><I><Y><V><A><S><V><H><Q><D><L><S><D><D><D><I><K><S><V><F><E><A><F><G><K><I><K><S><C><T><L><A><R><D><P><T><T><G><K><H><K><G><Y><G><F><I><E><Y><E><K><A><Q><S><S><Q><D><A><V><S><S><M><N><L><F><D><L><G><G><Q><Y><L><R><V><G><K><A><V><T><P><P><M><P><L><L><T><P><A><T><P><G><G><L><P><P><A><A><A><V><A><A><A><A><A><T><A><K><I><T><A><Q><E><A><V><A><G><A><A><V><L><G><T><L><G><T><P><G><L><V><S><P><A><L><T><L><A><Q><P><L><G><T><L><P><Q><A><V><M><A><A><Q><A><P><G><V><I><T><G><V><T><P><A><R><P><P><I><P><V><T><I><P><S><V><G><V><V><N><P><I><L><A><S><P><P><T><L><G><L><L><E><P><K><K><E><K><E><E><E><E><L><F><P><E><S><E><R><P><E><M><L><S><E><Q><E><H><M><S><I><S><G><S><S><A><R><H><M><V><M><Q><K><L><L><R><K><Q><E><S><T><V><M><V><L><R><N><M><V><D><P><K><D><I><D><D><D><L><E><G><E><V><T><E><E><C><G><K><F><G><A><V><N><R><V><I><I><Y><Q><E><K><Q><G><E><E><E><D><A><E><I><I><V><K><I><F><V><E><F><S><I><A><S><E><T><H><K><A><I><Q><A><L><N><G><R><W><F><A><G><R><K><V><V><A><E><V><Y><D><Q><E><R><F><D><N><S><D><L><S><A>
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3
Q9UHX1
P28070
PSB4_HUMAN
Proteasome chain 3
Homo
<M><E><A><F><L><G><S><R><S><G><L><W><A><G><G><P><A><P><G><Q><F><Y><R><I><P><S><T><P><D><S><F><M><D><P><A><S><A><L><Y><R><G><P><I><T><R><T><Q><N><P><M><V><T><G><T><S><V><L><G><V><K><F><E><G><G><V><V><I><A><A><D><M><L><G><S><Y><G><S><L><A><R><F><R><N><I><S><R><I><M><R><V><N><N><S><T><M><L><G><A><S><G><D><Y><A><D><F><Q><Y><L><K><Q><V><L><G><Q><M><V><I><D><E><E><L><L><G><D><G><H><S><Y><S><P><R><A><I><H><S><W><L><T><R><A><M><Y><S><R><R><S><K><M><N><P><L><W><N><T><M><V><I><G><G><Y><A><D><G><E><S><F><L><G><Y><V><D><M><L><G><V><A><Y><E><A><P><S><L><A><T><G><Y><G><A><Y><L><A><Q><P><L><L><R><E><V><L><E><K><Q><P><V><L><S><Q><T><E><A><R><D><L><V><E><R><C><M><R><V><L><Y><Y><R><D><A><R><S><Y><N><R><F><Q><I><A><T><V><T><E><K><G><V><E><I><E><G><P><L><S><T><E><T><N><W><D><I><A><H><M><I><S><G><F><E>
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.<BOP>
P28070
P33241
LSP1_HUMAN
Lymphocyte-specific antigen WP34
Homo
<M><A><E><A><S><S><D><P><G><A><E><E><R><E><E><L><L><G><P><T><A><Q><W><S><V><E><D><E><E><E><A><V><H><E><Q><C><Q><H><E><R><D><R><Q><L><Q><A><Q><D><E><E><G><G><G><H><V><P><E><R><P><K><Q><E><M><L><L><S><L><K><P><S><E><A><P><E><L><D><E><D><E><G><F><G><D><W><S><Q><R><P><E><Q><R><Q><Q><H><E><G><A><Q><G><A><L><D><S><G><E><P><P><Q><C><R><S><P><E><G><E><Q><E><D><R><P><G><L><H><A><Y><E><K><E><D><S><D><E><V><H><L><E><E><L><S><L><S><K><E><G><P><G><P><E><D><T><V><Q><D><N><L><G><A><A><G><A><E><E><E><Q><E><E><H><Q><K><C><Q><Q><P><R><T><P><S><P><L><V><L><E><G><T><I><E><Q><S><S><P><P><L><S><P><T><T><K><L><I><D><R><T><E><S><L><N><R><S><I><E><K><S><N><S><V><K><K><S><Q><P><D><L><P><I><S><K><I><D><Q><W><L><E><Q><Y><T><Q><A><I><E><T><A><G><R><T><P><K><L><A><R><Q><A><S><I><E><L><P><S><M><A><V><A><S><T><K><S><R><W><E><T><G><E><V><Q><A><Q><S><A><A><K><T><P><S><C><K><D><I><V><A><G><D><M><S><K><K><S><L><W><E><Q><K><G><G><S><K><T><S><S><T><I><K><S><T><P><S><G><K><R><Y><K><F><V><A><T><G><H><G><K><Y><E><K><V><L><V><E><G><G><P><A><P>
May play a role in mediating neutrophil activation and chemotaxis.<BOP>
P33241
Q96BP3
PPWD1_HUMAN
Spliceosome-associated cyclophilin
Homo
<M><A><A><E><S><G><S><D><F><Q><Q><R><R><R><R><R><R><D><P><E><E><P><E><K><T><E><L><S><E><R><E><L><A><V><A><V><A><V><S><Q><E><N><D><E><E><N><E><E><R><W><V><G><P><L><P><V><E><A><T><L><A><K><K><R><K><V><L><E><F><E><R><V><Y><L><D><N><L><P><S><A><S><M><Y><E><R><S><Y><M><H><R><D><V><I><T><H><V><V><C><T><K><T><D><F><I><I><T><A><S><H><D><G><H><V><K><F><W><K><K><I><E><E><G><I><E><F><V><K><H><F><R><S><H><L><G><V><I><E><S><I><A><V><S><S><E><G><A><L><F><C><S><V><G><D><D><K><A><M><K><V><F><D><V><V><N><F><D><M><I><N><M><L><K><L><G><Y><F><P><G><Q><C><E><W><I><Y><C><P><G><D><A><I><S><S><V><A><A><S><E><K><S><T><G><K><I><F><I><Y><D><G><R><G><D><N><Q><P><L><H><I><F><D><K><L><H><T><S><P><L><T><Q><I><R><L><N><P><V><Y><K><A><V><V><S><S><D><K><S><G><M><I><E><Y><W><T><G><P><P><H><E><Y><K><F><P><K><N><V><N><W><E><Y><K><T><D><T><D><L><Y><E><F><A><K><C><K><A><Y><P><T><S><V><C><F><S><P><D><G><K><K><I><A><T><I><G><S><D><R><K><V><R><I><F><R><F><V><T><G><K><L><M><R><V><F><D><E><S><L><S><M><F><T><E><L><Q><Q><M><R><Q><Q><L><P><D><M><E><F><G><R><R><M><A><V><E><R><E><L><E><K><V><D><A><V><R><L><I><N><I><V><F><D><E><T><G><H><F><V><L><Y><G><T><M><L><G><I><K><V><I><N><V><E><T><N><R><C><V><R><I><L><G><K><Q><E><N><I><R><V><M><Q><L><A><L><F><Q><G><I><A><K><K><H><R><A><A><T><T><I><E><M><K><A><S><E><N><P><V><L><Q><N><I><Q><A><D><P><T><I><V><C><T><S><F><K><K><N><R><F><Y><M><F><T><K><R><E><P><E><D><T><K><S><A><D><S><D><R><D><V><F><N><E><K><P><S><K><E><E><V><M><A><A><T><Q><A><E><G><P><K><R><V><S><D><S><A><I><I><H><T><S><M><G><D><I><H><T><K><L><F><P><V><E><C><P><K><T><V><E><N><F><C><V><H><S><R><N><G><Y><Y><N><G><H><T><F><H><R><I><I><K><G><F><M><I><Q><T><G><D><P><T><G><T><G><M><G><G><E><S><I><W><G><G><E><F><E><D><E><F><H><S><T><L><R><H><D><R><P><Y><T><L><S><M><A><N><A><G><S><N><T><N><G><S><Q><F><F><I><T><V><V><P><T><P><W><L><D><N><K><H><T><V><F><G><R><V><T><K><G><M><E><V><V><Q><R><I><S><N><V><K><V><N><P><K><T><D><K><P><Y><E><D><V><S><I><I><N><I><T><V><K>
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding . May be involved in pre-mRNA splicing .<BOP>
Q96BP3
Q96FV3
TSN17_HUMAN
Transmembrane 4 superfamily member 17
Homo
<M><P><G><K><H><Q><H><F><Q><E><P><E><V><G><C><C><G><K><Y><F><L><F><G><F><N><I><V><F><W><V><L><G><A><L><F><L><A><I><G><L><W><A><W><G><E><K><G><V><L><S><N><I><S><A><L><T><D><L><G><G><L><D><P><V><W><L><F><V><V><V><G><G><V><M><S><V><L><G><F><A><G><C><I><G><A><L><R><E><N><T><F><L><L><K><F><F><S><V><F><L><G><L><I><F><F><L><E><L><A><T><G><I><L><A><F><V><F><K><D><W><I><R><D><Q><L><N><L><F><I><N><N><N><V><K><A><Y><R><D><D><I><D><L><Q><N><L><I><D><F><A><Q><E><Y><W><S><C><C><G><A><R><G><P><N><D><W><N><L><N><I><Y><F><N><C><T><D><L><N><P><S><R><E><R><C><G><V><P><F><S><C><C><V><R><D><P><A><E><D><V><L><N><T><Q><C><G><Y><D><V><R><L><K><L><E><L><E><Q><Q><G><F><I><H><T><K><G><C><V><G><Q><F><E><K><W><L><Q><D><N><L><I><V><V><A><G><V><F><M><G><I><A><L><L><Q><I><F><G><I><C><L><A><Q><N><L><V><S><D><I><K><A><V><K><A><N><W>
Regulates ADAM10 maturation.<BOP>
Q96FV3
Q7Z3I7
ZN572_HUMAN
Zinc finger protein 572
Homo
<M><E><Q><E><K><K><L><L><V><S><D><S><N><S><F><M><E><R><E><S><L><K><S><P><F><T><G><D><T><S><M><N><N><L><E><T><V><H><H><N><N><S><K><A><D><K><L><K><E><K><P><S><E><W><S><K><R><H><R><P><Q><H><Y><K><H><E><D><A><K><E><M><P><L><T><W><V><Q><D><E><I><W><C><H><D><S><Y><E><S><D><G><K><S><E><N><W><G><N><F><I><A><K><E><E><E><K><P><N><H><Q><E><W><D><S><G><E><H><T><N><A><C><V><Q><Q><N><S><S><F><V><D><R><P><Y><K><C><S><E><C><W><K><S><F><S><N><S><S><H><L><R><T><H><Q><R><T><H><S><G><E><K><P><Y><K><C><S><E><C><A><K><C><F><C><N><S><S><H><L><I><Q><H><L><R><M><H><T><G><E><K><P><Y><Q><C><G><E><C><G><K><S><F><S><N><T><S><H><L><I><I><H><E><R><T><H><T><G><E><K><P><Y><K><C><P><E><C><G><K><R><F><S><S><S><S><H><L><I><Q><H><H><R><S><H><T><G><E><K><P><Y><E><C><S><V><C><G><K><G><F><S><H><S><Y><V><L><I><E><H><Q><R><T><H><T><G><E><K><P><Y><K><C><P><D><C><G><K><S><F><S><Q><S><S><S><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><K><C><L><E><C><E><K><S><F><G><C><N><S><T><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><Q><C><P><E><C><G><K><N><F><S><R><S><S><N><L><I><T><H><Q><K><M><H><T><G><E><K><S><Y><E><S><S><E><Y><E><E><S><L><G><Q><N><C><N><V><I><E><E><C><R><I><Q><L><G><E><K><P><Y><R><C><C><E><C><G><K><S><F><G><L><S><S><H><L><I><R><H><Q><R><T><H><T><G><E><K><P><Y><R><C><S><E><C><W><K><T><F><S><Q><S><S><T><L><V><I><H><Q><R><T><H><T><G><E><K><P><Y><K><C><P><D><C><G><E><S><F><S><Q><S><F><N><L><I><R><H><R><R><T><H><I><G><E><K><P><Y><K><C><T><S><C><E><K><C><F><S><R><S><A><Y><L><S><Q><H><R><K><I><H><V><E><K><P><F><E><S><P><D><V><G><D><F><P><H><E><W><T><W><K><N><C><S><G><E><M><P><F><I><S><S><F><S><V><S><N><S><S><S>
May be involved in transcriptional regulation.<BOP>
Q7Z3I7
Q9BW60
ELOV1_HUMAN
Very long chain 3-oxoacyl-CoA synthase 1
Homo
<M><E><A><V><V><N><L><Y><Q><E><V><M><K><H><A><D><P><R><I><Q><G><Y><P><L><M><G><S><P><L><L><M><T><S><I><L><L><T><Y><V><Y><F><V><L><S><L><G><P><R><I><M><A><N><R><K><P><F><Q><L><R><G><F><M><I><V><Y><N><F><S><L><V><A><L><S><L><Y><I><V><Y><E><F><L><M><S><G><W><L><S><T><Y><T><W><R><C><D><P><V><D><Y><S><N><S><P><E><A><L><R><M><V><R><V><A><W><L><F><L><F><S><K><F><I><E><L><M><D><T><V><I><F><I><L><R><K><K><D><G><Q><V><T><F><L><H><V><F><H><H><S><V><L><P><W><S><W><W><W><G><V><K><I><A><P><G><G><M><G><S><F><H><A><M><I><N><S><S><V><H><V><I><M><Y><L><Y><Y><G><L><S><A><F><G><P><V><A><Q><P><Y><L><W><W><K><K><H><M><T><A><I><Q><L><I><Q><F><V><L><V><S><L><H><I><S><Q><Y><Y><F><M><S><S><C><N><Y><Q><Y><P><V><I><I><H><L><I><W><M><Y><G><T><I><F><F><M><L><F><S><N><F><W><Y><H><S><Y><T><K><G><K><R><L><P><R><A><L><Q><Q><N><G><A><P><G><I><A><K><V><K><A><N>
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle . This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis . Indirectly inhibits RPE65 via production of VLCFAs.<BOP>
Q9BW60
Q8N8A6
DDX51_HUMAN
DEAD box protein 51
Homo
<M><A><L><F><Y><V><A><R><Y><P><G><P><D><A><A><A><A><A><G><P><E><G><A><E><A><G><A><H><G><R><A><R><A><L><L><E><R><L><Q><S><R><A><R><E><R><Q><Q><Q><R><E><P><A><Q><T><E><A><A><A><S><T><E><P><A><T><R><R><R><R><R><P><R><R><R><R><R><V><N><D><A><E><P><G><S><P><E><A><P><Q><G><K><R><R><K><A><D><G><E><D><A><G><A><E><S><N><E><E><A><P><G><E><P><S><A><G><S><S><E><E><A><P><G><E><P><S><A><G><S><S><E><E><A><P><G><E><R><S><T><S><A><S><A><E><A><A><P><D><G><P><A><L><E><E><A><A><G><P><L><V><P><G><L><V><L><G><G><F><G><K><R><K><A><P><K><V><Q><P><F><L><P><R><W><L><A><E><P><N><C><V><R><R><N><V><T><E><D><L><V><P><I><E><D><I><P><D><V><H><P><D><L><Q><K><Q><L><R><A><H><G><I><S><S><Y><F><P><V><Q><A><A><V><I><P><A><L><L><E><S><A><A><C><G><F><L><V><G><R><G><G><Y><R><P><S><D><L><C><V><S><A><P><T><G><S><G><K><T><L><A><F><V><I><P><V><V><Q><A><L><L><S><R><V><V><C><H><I><R><A><L><V><V><L><P><T><K><E><L><A><Q><Q><V><S><K><V><F><N><I><Y><T><D><A><T><P><L><R><V><S><L><V><T><G><Q><K><S><L><A><K><E><Q><E><S><L><V><Q><K><T><A><D><G><Y><R><C><L><A><D><I><V><V><A><T><P><G><R><L><V><D><H><I><D><Q><T><P><G><F><S><L><Q><Q><L><R><F><L><I><I><D><E><A><D><R><M><I><D><S><M><H><Q><S><W><L><P><R><V><V><A><A><A><F><Q><S><E><D><P><A><D><P><C><A><L><L><Q><R><R><Q><A><Q><A><V><T><A><A><S><T><C><C><P><Q><M><P><L><Q><K><L><L><F><S><A><T><L><T><Q><N><P><E><K><L><Q><Q><L><G><L><H><Q><P><R><L><F><S><T><G><L><A><H><R><G><L><E><D><T><D><G><D><G><D><S><G><K><Y><A><F><P><V><G><L><T><H><H><Y><V><P><C><S><L><S><S><K><P><L><V><V><L><H><L><V><L><E><M><G><F><S><R><V><L><C><F><T><N><S><R><E><N><S><H><R><L><F><L><L><V><Q><A><F><G><G><V><D><V><A><E><F><S><S><R><Y><G><P><G><Q><R><R><M><I><L><K><Q><F><E><Q><G><K><I><Q><L><L><I><S><T><D><A><T><A><R><G><I><D><V><Q><G><V><E><L><V><V><N><Y><D><A><P><Q><Y><L><R><T><Y><V><H><R><V><G><R><T><A><R><A><G><K><T><G><Q><A><F><T><L><L><L><K><V><Q><E><R><R><F><L><R><M><L><T><E><A><G><A><P><E><L><Q><R><H><E><L><S><S><K><L><L><Q><P><L><V><P><R><Y><E><E><A><L><S><Q><L><E><E><S><V><K><E><E><R><K><Q><R><A><A>
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.<BOP>
Q8N8A6
P42685
FRK_HUMAN
Protein-tyrosine kinase 5
Homo
<M><S><N><I><C><Q><R><L><W><E><Y><L><E><P><Y><L><P><C><L><S><T><E><A><D><K><S><T><V><I><E><N><P><G><A><L><C><S><P><Q><S><Q><R><H><G><H><Y><F><V><A><L><F><D><Y><Q><A><R><T><A><E><D><L><S><F><R><A><G><D><K><L><Q><V><L><D><T><L><H><E><G><W><W><F><A><R><H><L><E><K><R><R><D><G><S><S><Q><Q><L><Q><G><Y><I><P><S><N><Y><V><A><E><D><R><S><L><Q><A><E><P><W><F><F><G><A><I><G><R><S><D><A><E><K><Q><L><L><Y><S><E><N><K><T><G><S><F><L><I><R><E><S><E><S><Q><K><G><E><F><S><L><S><V><L><D><G><A><V><V><K><H><Y><R><I><K><R><L><D><E><G><G><F><F><L><T><R><R><R><I><F><S><T><L><N><E><F><V><S><H><Y><T><K><T><S><D><G><L><C><V><K><L><G><K><P><C><L><K><I><Q><V><P><A><P><F><D><L><S><Y><K><T><V><D><Q><W><E><I><D><R><N><S><I><Q><L><L><K><R><L><G><S><G><Q><F><G><E><V><W><E><G><L><W><N><N><T><T><P><V><A><V><K><T><L><K><P><G><S><M><D><P><N><D><F><L><R><E><A><Q><I><M><K><N><L><R><H><P><K><L><I><Q><L><Y><A><V><C><T><L><E><D><P><I><Y><I><I><T><E><L><M><R><H><G><S><L><Q><E><Y><L><Q><N><D><T><G><S><K><I><H><L><T><Q><Q><V><D><M><A><A><Q><V><A><S><G><M><A><Y><L><E><S><R><N><Y><I><H><R><D><L><A><A><R><N><V><L><V><G><E><H><N><I><Y><K><V><A><D><F><G><L><A><R><V><F><K><V><D><N><E><D><I><Y><E><S><R><H><E><I><K><L><P><V><K><W><T><A><P><E><A><I><R><S><N><K><F><S><I><K><S><D><V><W><S><F><G><I><L><L><Y><E><I><I><T><Y><G><K><M><P><Y><S><G><M><T><G><A><Q><V><I><Q><M><L><A><Q><N><Y><R><L><P><Q><P><S><N><C><P><Q><Q><F><Y><N><I><M><L><E><C><W><N><A><E><P><K><E><R><P><T><F><E><T><L><R><W><K><L><E><D><Y><F><E><T><D><S><S><Y><S><D><A><N><N><F><I><R>
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.<BOP>
P42685
O95484
CLD9_HUMAN
Claudin-9
Homo
<M><A><S><T><G><L><E><L><L><G><M><T><L><A><V><L><G><W><L><G><T><L><V><S><C><A><L><P><L><W><K><V><T><A><F><I><G><N><S><I><V><V><A><Q><V><V><W><E><G><L><W><M><S><C><V><V><Q><S><T><G><Q><M><Q><C><K><V><Y><D><S><L><L><A><L><P><Q><D><L><Q><A><A><R><A><L><C><V><I><A><L><L><L><A><L><L><G><L><L><V><A><I><T><G><A><Q><C><T><T><C><V><E><D><E><G><A><K><A><R><I><V><L><T><A><G><V><I><L><L><L><A><G><I><L><V><L><I><P><V><C><W><T><A><H><A><I><I><Q><D><F><Y><N><P><L><V><A><E><A><L><K><R><E><L><G><A><S><L><Y><L><G><W><A><A><A><A><L><L><M><L><G><G><G><L><L><C><C><T><C><P><P><P><Q><V><E><R><P><R><G><P><R><L><G><Y><S><I><P><S><R><S><G><A><S><G><L><D><K><R><D><Y><V>
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.<BOP>
O95484
Q567V2
M17L2_HUMAN
Mpv17-like protein 2
Homo
<M><A><R><G><G><W><R><R><L><R><R><L><L><S><A><G><Q><L><L><F><Q><G><R><A><L><L><V><T><N><T><L><G><C><G><A><L><M><A><A><G><D><G><V><R><Q><S><W><E><I><R><A><R><P><G><Q><V><F><D><P><R><R><S><A><S><M><F><A><V><G><C><S><M><G><P><F><L><H><Y><W><Y><L><S><L><D><R><L><F><P><A><S><G><L><R><G><F><P><N><V><L><K><K><V><L><V><D><Q><L><V><A><S><P><L><L><G><V><W><Y><F><L><G><L><G><C><L><E><G><Q><T><V><G><E><S><C><Q><E><L><R><E><K><F><W><E><F><Y><K><A><D><W><C><V><W><P><A><A><Q><F><V><N><F><L><F><V><P><P><Q><F><R><V><T><Y><I><N><G><L><T><L><G><W><D><T><Y><L><S><Y><L><K><Y><R><S><P><V><P><L><T><P><P><G><C><V><A><L><D><T><R><A><D>
Required for the assembly and stability of the mitochondrial ribosome . Is a positive regulator of mitochondrial protein synthesis .<BOP>
Q567V2
Q6ZUX7
LHPL2_HUMAN
Lipoma HMGIC fusion partner-like 2 protein
Homo
<M><C><H><V><I><V><T><C><R><S><M><L><W><T><L><L><S><I><V><V><A><F><A><E><L><I><A><F><M><S><A><D><W><L><I><G><K><A><R><S><R><G><G><V><E><P><A><G><P><G><G><G><S><P><E><P><Y><H><P><T><L><G><I><Y><A><R><C><I><R><N><P><G><V><Q><H><F><Q><R><D><T><L><C><G><P><Y><A><E><S><F><G><E><I><A><S><G><F><W><Q><A><T><A><I><F><L><A><V><G><I><F><I><L><C><M><V><A><L><V><S><V><F><T><M><C><V><Q><S><I><M><K><K><S><I><F><N><V><C><G><L><L><Q><G><I><A><G><L><F><L><I><L><G><L><I><L><Y><P><A><G><W><G><C><Q><K><A><I><D><Y><C><G><H><Y><A><S><A><Y><K><P><G><D><C><S><L><G><W><A><F><Y><T><A><I><G><G><T><V><L><T><F><I><C><A><V><F><S><A><Q><A><E><I><A><T><S><S><D><K><V><Q><E><E><I><E><E><G><K><N><L><I><C><L><L>
Plays a role in female and male fertility. Involved in distal reproductive tract development.<BOP>
Q6ZUX7
P08567
PLEK_HUMAN
Platelet 47 kDa protein
Homo
<M><E><P><K><R><I><R><E><G><Y><L><V><K><K><G><S><V><F><N><T><W><K><P><M><W><V><V><L><L><E><D><G><I><E><F><Y><K><K><K><S><D><N><S><P><K><G><M><I><P><L><K><G><S><T><L><T><S><P><C><Q><D><F><G><K><R><M><F><V><F><K><I><T><T><T><K><Q><Q><D><H><F><F><Q><A><A><F><L><E><E><R><D><A><W><V><R><D><I><K><K><A><I><K><C><I><E><G><G><Q><K><F><A><R><K><S><T><R><R><S><I><R><L><P><E><T><I><D><L><G><A><L><Y><L><S><M><K><D><T><E><K><G><I><K><E><L><N><L><E><K><D><K><K><I><F><N><H><C><F><T><G><N><C><V><I><D><W><L><V><S><N><Q><S><V><R><N><R><Q><E><G><L><M><I><A><S><S><L><L><N><E><G><Y><L><Q><P><A><G><D><M><S><K><S><A><V><D><G><T><A><E><N><P><F><L><D><N><P><D><A><F><Y><Y><F><P><D><S><G><F><F><C><E><E><N><S><S><D><D><D><V><I><L><K><E><E><F><R><G><V><I><I><K><Q><G><C><L><L><K><Q><G><H><R><R><K><N><W><K><V><R><K><F><I><L><R><E><D><P><A><Y><L><H><Y><Y><D><P><A><G><A><E><D><P><L><G><A><I><H><L><R><G><C><V><V><T><S><V><E><S><N><S><N><G><R><K><S><E><E><E><N><L><F><E><I><I><T><A><D><E><V><H><Y><F><L><Q><A><A><T><P><K><E><R><T><E><W><I><R><A><I><Q><M><A><S><R><T><G><K>
Major protein kinase C substrate of platelets.<BOP>
P08567
P27701
CD82_HUMAN
Tetraspanin-27
Homo
<M><G><S><A><C><I><K><V><T><K><Y><F><L><F><L><F><N><L><I><F><F><I><L><G><A><V><I><L><G><F><G><V><W><I><L><A><D><K><S><S><F><I><S><V><L><Q><T><S><S><S><S><L><R><M><G><A><Y><V><F><I><G><V><G><A><V><T><M><L><M><G><F><L><G><C><I><G><A><V><N><E><V><R><C><L><L><G><L><Y><F><A><F><L><L><L><I><L><I><A><Q><V><T><A><G><A><L><F><Y><F><N><M><G><K><L><K><Q><E><M><G><G><I><V><T><E><L><I><R><D><Y><N><S><S><R><E><D><S><L><Q><D><A><W><D><Y><V><Q><A><Q><V><K><C><C><G><W><V><S><F><Y><N><W><T><D><N><A><E><L><M><N><R><P><E><V><T><Y><P><C><S><C><E><V><K><G><E><E><D><N><S><L><S><V><R><K><G><F><C><E><A><P><G><N><R><T><Q><S><G><N><H><P><E><D><W><P><V><Y><Q><E><G><C><M><E><K><V><Q><A><W><L><Q><E><N><L><G><I><I><L><G><V><G><V><G><V><A><I><I><E><L><L><G><M><V><L><S><I><C><L><C><R><H><V><H><S><E><D><Y><S><K><V><P><K><Y>
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.<BOP>
P27701
Q9ULZ0
T53G3_HUMAN
TP53-inducible gene 3 protein
Homo
<M><R><A><S><P><C><I><S><Q><P><A><A><S><W><H><P><R><P><S><A><L><R><P><T><A><G><S><G><P><D><T><R><T><P><G><T><V><E><D><G><S><A><P><C><P><A><F><R><S><P><A><V><S><P><C><G><E><E><P><C><C><F><Q><I><S><P><A><E><E><T><L><E><L><G><R><L><V><S><P><G><N><C><D><T><L><S><P><R><A><A><G><F><Y><A><C><H><V><R><S><L><I><P><C><R><S><T><K><G><R><W><P><L><T><A><S><A><A><G><L><S><S><F><S><G>
May play a significant role in p53/TP53-mediating signaling pathway.<BOP>
Q9ULZ0
P32970
CD70_HUMAN
Tumor necrosis factor ligand superfamily member 7
Homo
<M><P><E><E><G><S><G><C><S><V><R><R><R><P><Y><G><C><V><L><R><A><A><L><V><P><L><V><A><G><L><V><I><C><L><V><V><C><I><Q><R><F><A><Q><A><Q><Q><Q><L><P><L><E><S><L><G><W><D><V><A><E><L><Q><L><N><H><T><G><P><Q><Q><D><P><R><L><Y><W><Q><G><G><P><A><L><G><R><S><F><L><H><G><P><E><L><D><K><G><Q><L><R><I><H><R><D><G><I><Y><M><V><H><I><Q><V><T><L><A><I><C><S><S><T><T><A><S><R><H><H><P><T><T><L><A><V><G><I><C><S><P><A><S><R><S><I><S><L><L><R><L><S><F><H><Q><G><C><T><I><A><S><Q><R><L><T><P><L><A><R><G><D><T><L><C><T><N><L><T><G><T><L><L><P><S><R><N><T><D><E><T><F><F><G><V><Q><W><V><R><P>
Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.<BOP>
P32970
Q8WXI9
P66B_HUMAN
p66/p68
Homo
<M><D><R><M><T><E><D><A><L><R><L><N><L><L><K><R><S><L><D><P><A><D><E><R><D><D><V><L><A><K><R><L><K><M><E><G><H><E><A><M><E><R><L><K><M><L><A><L><L><K><R><K><D><L><A><N><L><E><V><P><H><E><L><P><T><K><Q><D><G><S><G><V><K><G><Y><E><E><K><L><N><G><N><L><R><P><H><G><D><N><R><T><A><G><R><P><G><K><E><N><I><N><D><E><P><V><D><M><S><A><R><R><S><E><P><E><R><G><R><L><T><P><S><P><D><I><I><V><L><S><D><N><E><A><S><S><P><R><S><S><S><R><M><E><E><R><L><K><A><A><N><L><E><M><F><K><G><K><G><I><E><E><R><Q><Q><L><I><K><Q><L><R><D><E><L><R><L><E><E><A><R><L><V><L><L><K><K><L><R><Q><S><Q><L><Q><K><E><N><V><V><Q><K><T><P><V><V><Q><N><A><A><S><I><V><Q><P><S><P><A><H><V><G><Q><Q><G><L><S><K><L><P><S><R><P><G><A><Q><G><V><E><P><Q><N><L><R><T><L><Q><G><H><S><V><I><R><S><A><T><N><T><T><L><P><H><M><L><M><S><Q><R><V><I><A><P><N><P><A><Q><L><Q><G><Q><R><G><P><P><K><P><G><L><V><R><T><T><T><P><N><M><N><P><A><I><N><Y><Q><P><Q><S><S><S><S><V><P><C><Q><R><T><T><S><S><A><I><Y><M><N><L><A><S><H><I><Q><P><G><T><V><N><R><V><S><S><P><L><P><S><P><S><A><M><T><D><A><A><N><S><Q><A><A><A><K><L><A><L><R><K><Q><L><E><K><T><L><L><E><I><P><P><P><K><P><P><A><P><L><L><H><F><L><P><S><A><A><N><S><E><F><I><Y><M><V><G><L><E><E><V><V><Q><S><V><I><D><S><Q><G><K><S><C><A><S><L><L><R><V><E><P><F><V><C><A><Q><C><R><T><D><F><T><P><H><W><K><Q><E><K><N><G><K><I><L><C><E><Q><C><M><T><S><N><Q><K><K><A><L><K><A><E><H><T><N><R><L><K><N><A><F><V><K><A><L><Q><Q><E><Q><E><I><E><Q><R><L><Q><Q><Q><A><A><L><S><P><T><T><A><P><A><V><S><S><V><S><K><Q><E><T><I><M><R><H><H><T><L><R><Q><A><P><Q><P><Q><S><S><L><Q><R><G><I><P><T><S><A><R><S><M><L><S><N><F><A><Q><A><P><Q><L><S><V><P><G><G><L><L><G><M><P><G><V><N><I><A><Y><L><N><T><G><I><G><G><H><K><G><P><S><L><A><D><R><Q><R><E><Y><L><L><D><M><I><P><P><R><S><I><S><Q><S><I><S><G><Q><K>
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.<BOP>
Q8WXI9
P13489
RINI_HUMAN
Ribonuclease/angiogenin inhibitor 1
Homo
<M><S><L><D><I><Q><S><L><D><I><Q><C><E><E><L><S><D><A><R><W><A><E><L><L><P><L><L><Q><Q><C><Q><V><V><R><L><D><D><C><G><L><T><E><A><R><C><K><D><I><S><S><A><L><R><V><N><P><A><L><A><E><L><N><L><R><S><N><E><L><G><D><V><G><V><H><C><V><L><Q><G><L><Q><T><P><S><C><K><I><Q><K><L><S><L><Q><N><C><C><L><T><G><A><G><C><G><V><L><S><S><T><L><R><T><L><P><T><L><Q><E><L><H><L><S><D><N><L><L><G><D><A><G><L><Q><L><L><C><E><G><L><L><D><P><Q><C><R><L><E><K><L><Q><L><E><Y><C><S><L><S><A><A><S><C><E><P><L><A><S><V><L><R><A><K><P><D><F><K><E><L><T><V><S><N><N><D><I><N><E><A><G><V><R><V><L><C><Q><G><L><K><D><S><P><C><Q><L><E><A><L><K><L><E><S><C><G><V><T><S><D><N><C><R><D><L><C><G><I><V><A><S><K><A><S><L><R><E><L><A><L><G><S><N><K><L><G><D><V><G><M><A><E><L><C><P><G><L><L><H><P><S><S><R><L><R><T><L><W><I><W><E><C><G><I><T><A><K><G><C><G><D><L><C><R><V><L><R><A><K><E><S><L><K><E><L><S><L><A><G><N><E><L><G><D><E><G><A><R><L><L><C><E><T><L><L><E><P><G><C><Q><L><E><S><L><W><V><K><S><C><S><F><T><A><A><C><C><S><H><F><S><S><V><L><A><Q><N><R><F><L><L><E><L><Q><I><S><N><N><R><L><E><D><A><G><V><R><E><L><C><Q><G><L><G><Q><P><G><S><V><L><R><V><L><W><L><A><D><C><D><V><S><D><S><S><C><S><S><L><A><A><T><L><L><A><N><H><S><L><R><E><L><D><L><S><N><N><C><L><G><D><A><G><I><L><Q><L><V><E><S><V><R><Q><P><G><C><L><L><E><Q><L><V><L><Y><D><I><Y><W><S><E><E><M><E><D><R><L><Q><A><L><E><K><D><K><P><S><L><R><V><I><S>
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.<BOP>
P13489
Q9H0A6
RNF32_HUMAN
RING finger protein 32
Homo
<M><L><K><N><K><G><H><S><S><K><K><D><N><L><A><V><N><A><V><A><L><Q><D><H><I><L><H><D><L><Q><L><R><N><L><S><V><A><D><H><S><K><T><Q><V><Q><K><K><E><N><K><S><L><K><R><D><T><K><A><I><I><D><T><G><L><K><K><T><T><Q><C><P><K><L><E><D><S><E><K><E><Y><V><L><D><P><K><P><P><P><L><T><L><A><Q><K><L><G><L><I><G><P><P><P><P><P><L><S><S><D><E><W><E><K><V><K><Q><R><S><L><L><Q><G><D><S><V><Q><P><C><P><I><C><K><E><E><F><E><L><R><P><Q><V><L><L><S><C><S><H><V><F><H><K><A><C><L><Q><A><F><E><K><F><T><N><K><K><T><C><P><L><C><R><K><N><Q><Y><Q><T><R><V><I><H><D><G><A><R><L><F><R><I><K><C><V><T><R><I><Q><A><Y><W><R><G><C><V><V><R><K><W><Y><R><N><L><R><K><T><V><P><P><T><D><A><K><L><R><K><K><F><F><E><K><K><F><T><E><I><S><H><R><I><L><C><S><Y><N><T><N><I><E><E><L><F><A><E><I><D><Q><C><L><A><I><N><R><S><V><L><Q><Q><L><E><E><K><C><G><H><E><I><T><E><E><E><W><E><K><I><Q><V><Q><A><L><R><R><E><T><H><E><C><S><I><C><L><A><P><L><S><A><A><G><G><Q><R><V><G><A><G><R><R><S><R><E><M><A><L><L><S><C><S><H><V><F><H><H><A><C><L><L><A><L><E><E><F><S><V><G><D><R><P><P><F><H><A><C><P><L><C><R><S><C><Y><Q><K><K><I><L><E><C>
May play a role in sperm formation.<BOP>
Q9H0A6
Q969H6
POP5_HUMAN
Ribonuclease P/MRP protein subunit POP5
Homo
<M><V><R><F><K><H><R><Y><L><L><C><E><L><V><S><D><D><P><R><C><R><L><S><L><D><D><R><V><L><S><S><L><V><R><D><T><I><A><R><V><H><G><T><F><G><A><A><A><C><S><I><G><F><A><V><R><Y><L><N><A><Y><T><G><I><V><L><L><R><C><R><K><E><F><Y><Q><L><V><W><S><A><L><P><F><I><T><Y><L><E><N><K><G><H><R><Y><P><C><F><F><N><T><L><H><V><G><G><T><I><R><T><C><Q><K><F><L><I><Q><Y><N><R><R><Q><L><L><I><L><L><Q><N><C><T><D><E><G><E><R><E><A><I><Q><K><S><V><T><R><S><C><L><L><E><E><E><E><E><S><G><E><E><A><A><E><A><M><E>
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends . Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences .<BOP>
Q969H6
P78417
GSTO1_HUMAN
S-(Phenacyl)glutathione reductase
Homo
<M><S><G><E><S><A><R><S><L><G><K><G><S><A><P><P><G><P><V><P><E><G><S><I><R><I><Y><S><M><R><F><C><P><F><A><E><R><T><R><L><V><L><K><A><K><G><I><R><H><E><V><I><N><I><N><L><K><N><K><P><E><W><F><F><K><K><N><P><F><G><L><V><P><V><L><E><N><S><Q><G><Q><L><I><Y><E><S><A><I><T><C><E><Y><L><D><E><A><Y><P><G><K><K><L><L><P><D><D><P><Y><E><K><A><C><Q><K><M><I><L><E><L><F><S><K><V><P><S><L><V><G><S><F><I><R><S><Q><N><K><E><D><Y><A><G><L><K><E><E><F><R><K><E><F><T><K><L><E><E><V><L><T><N><K><K><T><T><F><F><G><G><N><S><I><S><M><I><D><Y><L><I><W><P><W><F><E><R><L><E><A><M><K><L><N><E><C><V><D><H><T><P><K><L><K><L><W><M><A><A><M><K><E><D><P><T><V><S><A><L><L><T><S><E><K><D><W><Q><G><F><L><E><L><Y><L><Q><N><S><P><E><A><C><D><Y><G><L>
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<BOP>
P78417
Q96MD2
KICS2_HUMAN
KICSTOR complex protein C12orf66
Homo
<M><G><E><S><I><P><L><A><A><P><V><P><V><E><Q><A><V><L><E><T><F><F><S><H><L><G><I><F><S><Y><D><K><A><K><D><N><V><E><K><E><R><E><A><N><K><S><A><G><G><S><W><L><S><L><L><A><A><L><A><H><L><A><A><A><E><K><V><Y><H><S><L><T><Y><L><G><Q><K><L><G><G><Q><S><F><F><S><R><K><D><S><I><R><T><I><Y><T><S><L><H><N><E><L><K><K><V><V><T><G><R><G><A><L><G><G><T><A><P><H><V><E><E><L><L><S><H><L><S><E><Q><L><C><F><F><V><Q><A><R><M><E><I><A><D><F><Y><E><K><M><Y><T><L><S><T><Q><K><F><I><N><A><E><E><L><V><G><L><L><D><A><I><M><K><K><Y><S><S><R><F><H><H><P><I><L><S><P><L><E><S><S><F><Q><L><E><V><D><V><L><C><H><L><L><K><A><Q><A><Q><V><S><E><W><K><F><L><P><S><L><V><N><L><H><S><A><H><T><K><L><Q><T><W><G><Q><I><F><E><K><Q><R><E><T><K><K><H><L><F><G><G><Q><S><Q><K><A><V><Q><P><P><H><L><F><L><W><L><M><K><L><K><N><M><L><L><A><K><F><S><F><Y><F><H><E><A><L><S><R><Q><T><T><A><S><E><M><K><T><L><T><A><K><A><N><P><D><F><F><G><K><I><S><S><F><I><R><K><Y><D><A><A><N><V><S><L><I><F><D><N><R><G><S><E><S><F><Q><G><H><G><Y><H><H><P><H><S><Y><R><E><A><P><K><G><V><D><Q><Y><P><A><V><V><S><L><P><S><D><R><P><V><M><H><W><P><N><V><I><M><I><M><T><D><R><T><S><D><L><N><S><L><E><K><V><V><H><F><Y><D><D><K><V><Q><S><T><Y><F><L><T><R><P><E><P><H><F><T><I><V><I><I><F><E><S><K><K><S><E><R><D><S><H><F><I><S><F><L><N><E><V><S><L><A><L><K><N><P><K><V><F><A><S><L><K><P><G><A><K><G>
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.<BOP>
Q96MD2
Q9H4X1
RGCC_HUMAN
Response gene to complement 32 protein
Homo
<M><K><P><P><A><A><Q><G><S><P><A><A><A><A><A><A><A><P><A><L><D><S><A><A><A><E><D><L><S><D><A><L><C><E><F><D><A><V><L><A><D><F><A><S><P><F><H><E><R><H><F><H><Y><E><E><H><L><E><R><M><K><R><R><S><S><A><S><V><S><D><S><S><G><F><S><D><S><E><S><A><D><S><L><Y><R><N><S><F><S><F><S><D><E><K><L><N><S><P><T><D><S><T><P><A><L><L><S><A><T><V><T><P><Q><K><A><K><L><G><D><T><K><E><L><E><A><F><I><A><D><L><D><K><T><L><A><S><M>
Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.<BOP>
Q9H4X1
Q7Z3D6
GLUCM_HUMAN
D-glutamate cyclase, mitochondrial
Homo
<M><P><F><T><L><H><L><R><S><R><L><P><S><A><I><R><S><L><I><L><Q><K><K><P><N><I><R><N><T><S><S><M><A><G><E><L><R><P><A><S><L><V><V><L><P><R><S><L><A><P><A><F><E><R><F><C><Q><V><N><T><G><P><L><P><L><L><G><Q><S><E><P><E><K><W><M><L><P><P><Q><G><A><I><S><E><T><R><M><G><H><P><Q><F><W><K><Y><E><F><G><A><C><T><G><S><L><A><S><L><E><Q><Y><S><E><Q><L><K><D><M><V><A><F><F><L><G><C><S><F><S><L><E><E><A><L><E><K><A><G><L><P><R><R><D><P><A><G><H><S><Q><T><T><V><P><C><V><T><H><A><G><F><C><C><P><L><V><V><T><M><R><P><I><P><K><D><K><L><E><G><L><V><R><A><C><C><S><L><G><G><E><Q><G><Q><P><V><H><M><G><D><P><E><L><L><G><I><K><E><L><S><K><P><A><Y><G><D><A><M><V><C><P><P><G><E><V><P><V><F><W><P><S><P><L><T><S><L><G><A><V><S><S><C><E><T><P><L><A><F><A><S><I><P><G><C><T><V><M><T><D><L><K><D><A><K><A><P><P><G><C><L><T><P><E><R><I><P><E><V><H><H><I><S><Q><D><P><L><H><Y><S><I><A><S><V><S><A><S><Q><K><I><R><E><L><E><S><M><I><G><I><D><P><G><N><R><G><I><G><H><L><L><C><K><D><E><L><L><K><A><S><L><S><L><S><H><A><R><S><V><L><I><T><T><G><F><P><T><H><F><N><H><E><P><P><E><E><T><D><G><P><P><G><A><V><A><L><V><A><F><L><Q><A><L><E><K><E><V><A><I><I><V><D><Q><R><A><W><N><L><H><Q><K><I><V><E><D><A><V><E><Q><G><V><L><K><T><Q><I><P><I><L><T><Y><Q><G><G><S><V><E><A><A><Q><A><F><L><C><K><N><G><D><P><Q><T><P><R><F><D><H><L><V><A><I><E><R><A><G><R><A><A><D><G><N><Y><Y><N><A><R><K><M><N><I><K><H><L><V><D><P><I><D><D><L><F><L><A><A><K><K><I><P><G><I><S><S><T><G><V><G><D><G><G><N><E><L><G><M><G><K><V><K><E><A><V><R><R><H><I><R><H><G><D><V><I><A><C><D><V><E><A><D><F><A><V><I><A><G><V><S><N><W><G><G><Y><A><L><A><C><A><L><Y><I><L><Y><S><C><A><V><H><S><Q><Y><L><R><K><A><V><G><P><S><R><A><P><G><D><Q><A><W><T><Q><A><L><P><S><V><I><K><E><E><K><M><L><G><I><L><V><Q><H><K><V><R><S><G><V><S><G><I><V><G><M><E><V><D><G><L><P><F><H><N><T><H><A><E><M><I><Q><K><L><V><D><V><T><T><A><Q><V>
D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.<BOP>
Q7Z3D6
Q14376
GALE_HUMAN
UDP-galactose 4-epimerase
Homo
<M><A><E><K><V><L><V><T><G><G><A><G><Y><I><G><S><H><T><V><L><E><L><L><E><A><G><Y><L><P><V><V><I><D><N><F><H><N><A><F><R><G><G><G><S><L><P><E><S><L><R><R><V><Q><E><L><T><G><R><S><V><E><F><E><E><M><D><I><L><D><Q><G><A><L><Q><R><L><F><K><K><Y><S><F><M><A><V><I><H><F><A><G><L><K><A><V><G><E><S><V><Q><K><P><L><D><Y><Y><R><V><N><L><T><G><T><I><Q><L><L><E><I><M><K><A><H><G><V><K><N><L><V><F><S><S><S><A><T><V><Y><G><N><P><Q><Y><L><P><L><D><E><A><H><P><T><G><G><C><T><N><P><Y><G><K><S><K><F><F><I><E><E><M><I><R><D><L><C><Q><A><D><K><T><W><N><A><V><L><L><R><Y><F><N><P><T><G><A><H><A><S><G><C><I><G><E><D><P><Q><G><I><P><N><N><L><M><P><Y><V><S><Q><V><A><I><G><R><R><E><A><L><N><V><F><G><N><D><Y><D><T><E><D><G><T><G><V><R><D><Y><I><H><V><V><D><L><A><K><G><H><I><A><A><L><R><K><L><K><E><Q><C><G><C><R><I><Y><N><L><G><T><G><T><G><Y><S><V><L><Q><M><V><Q><A><M><E><K><A><S><G><K><K><I><P><Y><K><V><V><A><R><R><E><G><D><V><A><A><C><Y><A><N><P><S><L><A><Q><E><E><L><G><W><T><A><A><L><G><L><D><R><M><C><E><D><L><W><R><W><Q><K><Q><N><P><S><G><F><G><T><Q><A>
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.<BOP>
Q14376
Q8NGQ3
OR1S2_HUMAN
Olfactory receptor OR11-231
Homo
<M><K><T><L><C><S><F><L><Q><I><S><R><N><M><H><Q><E><N><Q><T><T><I><T><E><F><I><L><L><G><L><S><N><Q><A><E><H><Q><N><L><L><F><V><L><F><L><S><M><Y><V><V><T><V><V><G><N><G><L><I><I><V><A><I><S><L><D><I><Y><L><H><T><P><M><Y><L><F><L><A><Y><L><S><F><A><D><I><S><S><I><S><N><S><V><P><K><M><L><V><N><I><Q><T><N><S><Q><S><I><S><Y><E><S><C><I><T><Q><M><Y><F><S><I><V><F><V><V><T><D><N><L><L><L><G><T><M><A><F><D><H><F><V><A><I><C><H><P><L><N><Y><T><T><F><M><R><A><R><F><G><T><L><L><T><V><I><S><W><F><L><S><N><I><I><A><L><T><H><T><L><L><L><I><Q><L><L><F><C><D><H><N><T><L><P><H><F><F><C><D><L><A><P><L><L><K><L><S><C><S><D><T><M><I><N><E><L><V><L><F><I><V><G><L><S><V><I><I><F><P><F><V><L><I><F><F><S><Y><V><C><I><I><R><A><V><L><G><V><S><S><T><Q><G><K><W><K><A><F><S><T><C><G><S><H><L><T><I><A><L><L><F><Y><G><T><T><V><G><V><Y><F><F><P><S><S><T><H><P><E><D><T><D><K><I><G><A><V><L><F><T><V><V><T><P><M><M><N><P><F><I><Y><S><L><R><N><K><D><M><K><G><A><L><R><K><L><I><N><R><K><I><S><S><L>
Odorant receptor.<BOP>
Q8NGQ3
O95379
TFIP8_HUMAN
TNF-induced protein GG2-1
Homo
<M><H><S><E><A><E><E><S><K><E><V><A><T><D><V><F><N><S><K><N><L><A><V><Q><A><Q><K><K><I><L><G><K><M><V><S><K><S><I><A><T><T><L><I><D><D><T><S><S><E><V><L><D><E><L><Y><R><V><T><R><E><Y><T><Q><N><K><K><E><A><E><K><I><I><K><N><L><I><K><T><V><I><K><L><A><I><L><Y><R><N><N><Q><F><N><Q><D><E><L><A><L><M><E><K><F><K><K><K><V><H><Q><L><A><M><T><V><V><S><F><H><Q><V><D><Y><T><F><D><R><N><V><L><S><R><L><L><N><E><C><R><E><M><L><H><Q><I><I><Q><R><H><L><T><A><K><S><H><G><R><V><N><N><V><F><D><H><F><S><D><C><E><F><L><A><A><L><Y><N><P><F><G><N><F><K><P><H><L><Q><K><L><C><D><G><I><N><K><M><L><D><E><E><N><I>
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.<BOP>
O95379
P46094
XCR1_HUMAN
XC chemokine receptor 1
Homo
<M><E><S><S><G><N><P><E><S><T><T><F><F><Y><Y><D><L><Q><S><Q><P><C><E><N><Q><A><W><V><F><A><T><L><A><T><T><V><L><Y><C><L><V><F><L><L><S><L><V><G><N><S><L><V><L><W><V><L><V><K><Y><E><S><L><E><S><L><T><N><I><F><I><L><N><L><C><L><S><D><L><V><F><A><C><L><L><P><V><W><I><S><P><Y><H><W><G><W><V><L><G><D><F><L><C><K><L><L><N><M><I><F><S><I><S><L><Y><S><S><I><F><F><L><T><I><M><T><I><H><R><Y><L><S><V><V><S><P><L><S><T><L><R><V><P><T><L><R><C><R><V><L><V><T><M><A><V><W><V><A><S><I><L><S><S><I><L><D><T><I><F><H><K><V><L><S><S><G><C><D><Y><S><E><L><T><W><Y><L><T><S><V><Y><Q><H><N><L><F><F><L><L><S><L><G><I><I><L><F><C><Y><V><E><I><L><R><T><L><F><R><S><R><S><K><R><R><H><R><T><V><K><L><I><F><A><I><V><V><A><Y><F><L><S><W><G><P><Y><N><F><T><L><F><L><Q><T><L><F><R><T><Q><I><I><R><S><C><E><A><K><Q><Q><L><E><Y><A><L><L><I><C><R><N><L><A><F><S><H><C><C><F><N><P><V><L><Y><V><F><V><G><V><K><F><R><T><H><L><K><H><V><L><R><Q><F><W><F><C><R><L><Q><A><P><S><P><A><S><I><P><H><S><P><G><A><F><A><Y><E><G><A><S><F><Y>
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.<BOP>
P46094
Q8NBS9
TXND5_HUMAN
Thioredoxin-like protein p46
Homo
<M><P><A><R><P><G><R><L><L><P><L><L><A><R><P><A><A><L><T><A><L><L><L><L><L><L><G><H><G><G><G><G><R><W><G><A><R><A><Q><E><A><A><A><A><A><A><D><G><P><P><A><A><D><G><E><D><G><Q><D><P><H><S><K><H><L><Y><T><A><D><M><F><T><H><G><I><Q><S><A><A><H><F><V><M><F><F><A><P><W><C><G><H><C><Q><R><L><Q><P><T><W><N><D><L><G><D><K><Y><N><S><M><E><D><A><K><V><Y><V><A><K><V><D><C><T><A><H><S><D><V><C><S><A><Q><G><V><R><G><Y><P><T><L><K><L><F><K><P><G><Q><E><A><V><K><Y><Q><G><P><R><D><F><Q><T><L><E><N><W><M><L><Q><T><L><N><E><E><P><V><T><P><E><P><E><V><E><P><P><S><A><P><E><L><K><Q><G><L><Y><E><L><S><A><S><N><F><E><L><H><V><A><Q><G><D><H><F><I><K><F><F><A><P><W><C><G><H><C><K><A><L><A><P><T><W><E><Q><L><A><L><G><L><E><H><S><E><T><V><K><I><G><K><V><D><C><T><Q><H><Y><E><L><C><S><G><N><Q><V><R><G><Y><P><T><L><L><W><F><R><D><G><K><K><V><D><Q><Y><K><G><K><R><D><L><E><S><L><R><E><Y><V><E><S><Q><L><Q><R><T><E><T><G><A><T><E><T><V><T><P><S><E><A><P><V><L><A><A><E><P><E><A><D><K><G><T><V><L><A><L><T><E><N><N><F><D><D><T><I><A><E><G><I><T><F><I><K><F><Y><A><P><W><C><G><H><C><K><T><L><A><P><T><W><E><E><L><S><K><K><E><F><P><G><L><A><G><V><K><I><A><E><V><D><C><T><A><E><R><N><I><C><S><K><Y><S><V><R><G><Y><P><T><L><L><L><F><R><G><G><K><K><V><S><E><H><S><G><G><R><D><L><D><S><L><H><R><F><V><L><S><Q><A><K><D><E><L>
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.<BOP>
Q8NBS9
Q5TBB1
RNH2B_HUMAN
Ribonuclease HI subunit B
Homo
<M><A><A><G><V><D><C><G><D><G><V><G><A><R><Q><H><V><F><L><V><S><E><Y><L><K><D><A><S><K><K><M><K><N><G><L><M><F><V><K><L><V><N><P><C><S><G><E><G><A><I><Y><L><F><N><M><C><L><Q><Q><L><F><E><V><K><V><F><K><E><K><H><H><S><W><F><I><N><Q><S><V><Q><S><G><G><L><L><H><F><A><T><P><V><D><P><L><F><L><L><L><H><Y><L><I><K><A><D><K><E><G><K><F><Q><P><L><D><Q><V><V><V><D><N><V><F><P><N><C><I><L><L><L><K><L><P><G><L><E><K><L><L><H><H><V><T><E><E><K><G><N><P><E><I><D><N><K><K><Y><Y><K><Y><S><K><E><K><T><L><K><W><L><E><K><K><V><N><Q><T><V><A><A><L><K><T><N><N><V><N><V><S><S><R><V><Q><S><T><A><F><F><S><G><D><Q><A><S><T><D><K><E><E><D><Y><I><R><Y><A><H><G><L><I><S><D><Y><I><P><K><E><L><S><D><D><L><S><K><Y><L><K><L><P><E><P><S><A><S><L><P><N><P><P><S><K><K><I><K><L><S><D><E><P><V><E><A><K><E><D><Y><T><K><F><N><T><K><D><L><K><T><E><K><K><N><S><K><M><T><A><A><Q><K><A><L><A><K><V><D><K><S><G><M><K><S><I><D><T><F><F><G><V><K><N><K><K><K><I><G><K><V>
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.<BOP>
Q5TBB1
Q8WWY7
WFD12_HUMAN
Whey acidic protein 2
Homo
<M><G><S><S><S><F><L><V><L><M><V><S><L><V><L><V><T><L><V><A><V><E><G><V><K><E><G><I><E><K><A><G><V><C><P><A><D><N><V><R><C><F><K><S><D><P><P><Q><C><H><T><D><Q><D><C><L><G><E><R><K><C><C><Y><L><H><C><G><F><K><C><V><I><P><V><K><E><L><E><E><G><G><N><K><D><E><D><V><S><R><P><Y><P><E><P><G><W><E><A><K><C><P><G><S><S><S><T><R><C><P><Q><K>
Antibacterial protein. Putative acid-stable proteinase inhibitor.<BOP>
Q8WWY7
Q8IWE2
NXP20_HUMAN
Protein FAM114A1
Homo
<M><S><D><D><A><G><D><T><L><A><T><G><D><K><A><E><V><T><E><M><P><N><S><D><S><L><P><E><D><A><E><V><H><C><D><S><A><A><V><S><H><E><P><T><P><A><D><P><R><G><E><G><H><E><N><A><A><V><Q><G><A><G><A><A><A><I><G><P><P><V><Q><P><Q><D><A><N><A><L><E><P><P><L><N><G><D><V><T><E><D><T><L><A><E><C><I><D><S><V><S><L><E><A><E><P><R><S><E><I><P><L><Q><E><Q><N><Y><L><A><V><D><S><P><P><S><G><G><G><W><A><G><W><G><S><W><G><K><S><L><L><S><S><A><S><A><T><V><G><H><G><L><T><A><V><K><E><K><A><G><A><T><L><R><I><H><G><V><N><S><G><S><S><E><G><A><Q><P><N><T><E><N><G><V><P><E><I><T><D><A><A><T><D><Q><G><P><A><E><S><P><P><T><S><P><S><S><A><S><R><G><M><L><S><A><I><T><N><V><V><Q><N><T><G><K><S><V><L><T><G><G><L><D><A><L><E><F><I><G><K><K><T><M><N><V><L><A><E><S><D><P><G><F><K><R><T><K><T><L><M><E><R><T><V><S><L><S><Q><M><L><R><E><A><K><E><K><E><K><Q><R><L><A><Q><Q><L><T><M><E><R><T><A><H><Y><G><M><L><F><D><E><Y><Q><G><L><S><H><L><E><A><L><E><I><L><S><N><E><S><E><S><K><V><Q><S><F><L><A><S><L><D><G><E><K><L><E><L><L><K><N><D><L><I><S><I><K><D><I><F><A><A><K><E><L><E><N><E><E><N><Q><E><E><Q><G><L><E><E><K><G><E><E><F><A><R><M><L><T><E><L><L><F><E><L><H><V><A><A><T><P><D><K><L><N><K><A><M><K><R><A><H><D><W><V><E><E><D><Q><T><V><V><S><V><D><V><A><K><V><S><E><E><E><T><K><K><E><E><K><E><E><K><S><Q><D><P><Q><E><D><K><K><E><E><K><K><T><K><T><I><E><E><V><Y><M><S><S><I><E><S><L><A><E><V><T><A><R><C><I><E><Q><L><H><K><V><A><E><L><I><L><H><G><Q><E><E><E><K><P><A><Q><D><Q><A><K><V><L><I><K><L><T><T><A><M><C><N><E><V><A><S><L><S><K><K><F><T><N><S><L><T><T><V><G><S><N><K><K><A><E><V><L><N><P><M><I><S><S><V><L><L><E><G><C><N><S><T><T><Y><I><Q><D><A><F><Q><L><L><L><P><V><L><Q><V><S><H><I><Q><T><S><C><L><K><A><Q><P>
May play a role in neuronal cell development.<BOP>
Q8IWE2
Q6ICG8
WBP2L_HUMAN
WW domain-binding protein 2-like
Homo
<M><A><V><N><Q><S><H><T><E><N><R><R><G><A><L><I><P><N><G><E><S><L><L><K><R><S><P><N><V><E><L><S><F><P><Q><R><S><E><G><S><N><V><F><S><G><R><K><T><G><T><L><F><L><T><S><Y><R><V><I><F><I><T><S><C><S><I><S><D><P><M><L><S><F><M><M><P><F><D><L><M><T><N><L><T><V><E><Q><P><V><F><A><A><N><F><I><K><G><T><I><Q><A><A><P><Y><G><G><W><E><G><Q><A><T><F><K><L><V><F><R><N><G><D><A><I><E><F><A><Q><L><M><V><K><A><A><S><A><A><A><R><G><F><P><L><R><T><L><N><D><W><F><S><S><M><G><I><Y><V><I><T><G><E><G><N><M><C><T><P><Q><M><P><C><S><V><I><V><Y><G><A><P><P><A><G><Y><G><A><P><P><P><G><Y><G><A><P><P><A><G><Y><G><A><Q><P><V><G><N><E><G><P><P><V><G><Y><R><A><S><P><V><R><Y><G><A><P><P><L><G><Y><G><A><P><P><A><G><Y><G><A><P><P><L><G><Y><G><A><P><P><L><G><Y><G><T><P><P><L><G><Y><G><A><P><P><L><G><Y><G><A><P><P><A><G><N><E><G><P><P><A><G><Y><R><A><S><P><A><G><S><G><A><R><P><Q><E><S><T><A><A><Q><A><P><E><N><E><A><S><L><P><S><A><S><S><S><Q><V><H><S>
May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.<BOP>
Q6ICG8
Q9BXD5
NPL_HUMAN
Sialic acid lyase
Homo
<M><A><F><P><K><K><K><L><Q><G><L><V><A><A><T><I><T><P><M><T><E><N><G><E><I><N><F><S><V><I><G><Q><Y><V><D><Y><L><V><K><E><Q><G><V><K><N><I><F><V><N><G><T><T><G><E><G><L><S><L><S><V><S><E><R><R><Q><V><A><E><E><W><V><T><K><G><K><D><K><L><D><Q><V><I><I><H><V><G><A><L><S><L><K><E><S><Q><E><L><A><Q><H><A><A><E><I><G><A><D><G><I><A><V><I><A><P><F><F><L><K><P><W><T><K><D><I><L><I><N><F><L><K><E><V><A><A><A><A><P><A><L><P><F><Y><Y><Y><H><I><P><A><L><T><G><V><K><I><R><A><E><E><L><L><D><G><I><L><D><K><I><P><T><F><Q><G><L><K><F><S><D><T><D><L><L><D><F><G><Q><C><V><D><Q><N><R><Q><Q><Q><F><A><F><L><F><G><V><D><E><Q><L><L><S><A><L><V><M><G><A><T><G><A><V><G><S><T><Y><N><Y><L><G><K><K><T><N><Q><M><L><E><A><F><E><Q><K><D><F><S><L><A><L><N><Y><Q><F><C><I><Q><R><F><I><N><F><V><V><K><L><G><F><G><V><S><Q><T><K><A><I><M><T><L><V><S><G><I><P><M><G><P><P><R><L><P><L><Q><K><A><S><R><E><F><T><D><S><A><E><A><K><L><K><S><L><D><F><L><S><F><T><D><L><K><D><G><N><L><E><A><G><S>
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate . It prevents sialic acids from being recycled and returning to the cell surface . Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway . Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable).<BOP>
Q9BXD5
P53004
BIEA_HUMAN
Biliverdin-IX alpha-reductase
Homo
<M><N><A><E><P><E><R><K><F><G><V><V><V><V><G><V><G><R><A><G><S><V><R><M><R><D><L><R><N><P><H><P><S><S><A><F><L><N><L><I><G><F><V><S><R><R><E><L><G><S><I><D><G><V><Q><Q><I><S><L><E><D><A><L><S><S><Q><E><V><E><V><A><Y><I><C><S><E><S><S><S><H><E><D><Y><I><R><Q><F><L><N><A><G><K><H><V><L><V><E><Y><P><M><T><L><S><L><A><A><A><Q><E><L><W><E><L><A><E><Q><K><G><K><V><L><H><E><E><H><V><E><L><L><M><E><E><F><A><F><L><K><K><E><V><V><G><K><D><L><L><K><G><S><L><L><F><T><A><G><P><L><E><E><E><R><F><G><F><P><A><F><S><G><I><S><R><L><T><W><L><V><S><L><F><G><E><L><S><L><V><S><A><T><L><E><E><R><K><E><D><Q><Y><M><K><M><T><V><C><L><E><T><E><K><K><S><P><L><S><W><I><E><E><K><G><P><G><L><K><R><N><R><Y><L><S><F><H><F><K><S><G><S><L><E><N><V><P><N><V><G><V><N><K><N><I><F><L><K><D><Q><N><I><F><V><Q><K><L><L><G><Q><F><S><E><K><E><L><A><A><E><K><K><R><I><L><H><C><L><G><L><A><E><E><I><Q><K><Y><C><C><S><R><K>
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor . Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) . NADPH, however, is the probable reactant in biological systems .<BOP>
P53004
Q9NP56
PDE7B_HUMAN
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Homo
<M><S><C><L><M><V><E><R><C><G><E><I><L><F><E><N><P><D><Q><N><A><K><C><V><C><M><L><G><D><I><R><L><R><G><Q><T><G><V><R><A><E><R><R><G><S><Y><P><F><I><D><F><R><L><L><N><S><T><T><Y><S><G><E><I><G><T><K><K><K><V><K><R><L><L><S><F><Q><R><Y><F><H><A><S><R><L><L><R><G><I><I><P><Q><A><P><L><H><L><L><D><E><D><Y><L><G><Q><A><R><H><M><L><S><K><V><G><M><W><D><F><D><I><F><L><F><D><R><L><T><N><G><N><S><L><V><T><L><L><C><H><L><F><N><T><H><G><L><I><H><H><F><K><L><D><M><V><T><L><H><R><F><L><V><M><V><Q><E><D><Y><H><S><Q><N><P><Y><H><N><A><V><H><A><A><D><V><T><Q><A><M><H><C><Y><L><K><E><P><K><L><A><S><F><L><T><P><L><D><I><M><L><G><L><L><A><A><A><A><H><D><V><D><H><P><G><V><N><Q><P><F><L><I><K><T><N><H><H><L><A><N><L><Y><Q><N><M><S><V><L><E><N><H><H><W><R><S><T><I><G><M><L><R><E><S><R><L><L><A><H><L><P><K><E><M><T><Q><D><I><E><Q><Q><L><G><S><L><I><L><A><T><D><I><N><R><Q><N><E><F><L><T><R><L><K><A><H><L><H><N><K><D><L><R><L><E><D><A><Q><D><R><H><F><M><L><Q><I><A><L><K><C><A><D><I><C><N><P><C><R><I><W><E><M><S><K><Q><W><S><E><R><V><C><E><E><F><Y><R><Q><G><E><L><E><Q><K><F><E><L><E><I><S><P><L><C><N><Q><Q><K><D><S><I><P><S><I><Q><I><G><F><M><S><Y><I><V><E><P><L><F><R><E><W><A><H><F><T><G><N><S><T><L><S><E><N><M><L><G><H><L><A><H><N><K><A><Q><W><K><S><L><L><P><R><Q><H><R><S><R><G><S><S><G><S><G><P><D><H><D><H><A><G><Q><G><T><E><S><E><E><Q><E><G><D><S><P>
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain .<BOP>
Q9NP56
Q86Y27
BAGE5_HUMAN
Cancer/testis antigen 2.5
Homo
<M><A><A><G><A><V><F><L><A><L><S><A><Q><L><L><Q><A><R><L><M><K><E><E><S><P><V><V><S><W><R><L><E><P><E><D><G><T><A><L><C><F><I><F>
Unknown. Candidate gene encoding tumor antigens.<BOP>
Q86Y27
Q14140
SRTD2_HUMAN
Transcriptional regulator interacting with the PHD-bromodomain 2
Homo
<M><L><G><K><G><G><K><R><K><F><D><E><H><E><D><G><L><E><G><K><I><V><S><P><C><D><G><P><S><K><V><S><Y><T><L><Q><R><Q><T><I><F><N><I><S><L><M><K><L><Y><N><H><R><P><L><T><E><P><S><L><Q><K><T><V><L><I><N><N><M><L><R><R><I><Q><E><E><L><K><Q><E><G><S><L><R><P><M><F><T><P><S><S><Q><P><T><T><E><P><S><D><S><Y><R><E><A><P><P><A><F><S><H><L><A><S><P><S><S><H><P><C><D><L><G><S><T><T><P><L><E><A><C><L><T><P><A><S><L><L><E><D><D><D><D><T><F><C><T><S><Q><A><M><Q><P><T><A><P><T><K><L><S><P><P><A><L><L><P><E><K><D><S><F><S><S><A><L><D><E><I><E><E><L><C><P><T><S><T><S><T><E><A><A><T><A><A><T><D><S><V><K><G><T><S><S><E><A><G><T><Q><K><L><D><G><P><Q><E><S><R><A><D><D><S><K><L><M><D><S><L><P><G><N><F><E><I><T><T><S><T><G><F><L><T><D><L><T><L><D><D><I><L><F><A><D><I><D><T><S><M><Y><D><F><D><P><C><T><S><S><S><G><T><A><S><K><M><A><P><V><S><A><D><D><L><L><K><T><L><A><P><Y><S><S><Q><P><V><T><P><S><Q><P><F><K><M><D><L><T><E><L><D><H><I><M><E><V><L><V><G><S>
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.<BOP>
Q14140
Q5JPH6
SYEM_HUMAN
Glutamyl-tRNA synthetase
Homo
<M><A><A><L><L><R><R><L><L><Q><R><E><R><P><S><A><A><S><G><R><P><V><G><R><R><E><A><N><L><G><T><D><A><G><V><A><V><R><V><R><F><A><P><S><P><T><G><F><L><H><L><G><G><L><R><T><A><L><Y><N><Y><I><F><A><K><K><Y><Q><G><S><F><I><L><R><L><E><D><T><D><Q><T><R><V><V><P><G><A><A><E><N><I><E><D><M><L><E><W><A><G><I><P><P><D><E><S><P><R><R><G><G><P><A><G><P><Y><Q><Q><S><Q><R><L><E><L><Y><A><Q><A><T><E><A><L><L><K><T><G><A><A><Y><P><C><F><C><S><P><Q><R><L><E><L><L><K><K><E><A><L><R><N><H><Q><T><P><R><Y><D><N><R><C><R><N><M><S><Q><E><Q><V><A><Q><K><L><A><K><D><P><K><P><A><I><R><F><R><L><E><Q><V><V><P><A><F><Q><D><L><V><Y><G><W><N><R><H><E><V><A><S><V><E><G><D><P><V><I><M><K><S><D><G><F><P><T><Y><H><L><A><C><V><V><D><D><H><H><M><G><I><S><H><V><L><R><G><S><E><W><L><V><S><T><A><K><H><L><L><L><Y><Q><A><L><G><W><Q><P><P><H><F><A><H><L><P><L><L><L><N><R><D><G><S><K><L><S><K><R><Q><G><D><V><F><L><E><H><F><A><A><D><G><F><L><P><D><S><L><L><D><I><I><T><N><C><G><S><G><F><A><E><N><Q><M><G><R><T><L><P><E><L><I><T><Q><F><N><L><T><Q><V><T><C><H><S><A><L><L><D><L><E><K><L><P><E><F><N><R><L><H><L><Q><R><L><V><S><N><E><S><Q><R><R><Q><L><V><G><K><L><Q><V><L><V><E><E><A><F><G><C><Q><L><Q><N><R><D><V><L><N><P><V><Y><V><E><R><I><L><L><L><R><Q><G><H><I><C><R><L><Q><D><L><V><S><P><V><Y><S><Y><L><W><T><R><P><A><V><G><R><A><Q><L><D><A><I><S><E><K><V><D><V><I><A><K><R><V><L><G><L><L><E><R><S><S><M><S><L><T><Q><D><M><L><N><G><E><L><K><K><L><S><E><G><L><E><G><T><K><Y><S><N><V><M><K><L><L><R><M><A><L><S><G><Q><Q><Q><G><P><P><V><A><E><M><M><L><A><L><G><P><K><E><V><R><E><R><I><Q><K><V><V><S><S>
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).<BOP>
Q5JPH6
Q0VGL1
LTOR4_HUMAN
Ragulator complex protein LAMTOR4, N-terminally processed
Homo
<M><T><S><A><L><T><Q><G><L><E><R><I><P><D><Q><L><G><Y><L><V><L><S><E><G><A><V><L><A><S><S><G><D><L><E><N><D><E><Q><A><A><S><A><I><S><E><L><V><S><T><A><C><G><F><R><L><H><R><G><M><N><V><P><F><K><R><L><S><V><V><F><G><E><H><T><L><L><V><T><V><S><G><Q><R><V><F><V><V><K><R><Q><N><R><G><R><E><P><I><D><V>
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<BOP>
Q0VGL1
Q9BTV6
DPH7_HUMAN
WD repeat-containing protein 85
Homo
<M><M><G><C><F><A><L><Q><T><V><D><T><E><L><T><A><D><S><V><E><W><C><P><L><Q><G><C><R><H><L><L><A><C><G><T><Y><Q><L><R><R><P><E><D><R><P><A><G><P><Q><N><K><G><G><M><E><V><K><E><P><Q><V><R><L><G><R><L><F><L><Y><S><F><N><D><N><N><S><I><H><P><L><V><E><V><Q><R><K><D><T><S><A><I><L><D><M><K><W><C><H><I><P><V><A><G><H><A><L><L><G><L><A><D><A><S><G><S><I><Q><L><L><R><L><V><E><S><E><K><S><H><V><L><E><P><L><S><S><L><A><L><E><E><Q><C><L><A><L><S><L><D><W><S><T><G><K><T><G><R><A><G><D><Q><P><L><K><I><I><S><S><D><S><T><G><Q><L><H><L><L><M><V><N><E><T><R><P><R><L><Q><K><V><A><S><W><Q><A><H><Q><F><E><A><W><I><A><A><F><N><Y><W><H><P><E><I><V><Y><S><G><G><D><D><G><L><L><R><G><W><D><T><R><V><P><G><K><F><L><F><T><S><K><R><H><T><M><G><V><C><S><I><Q><S><S><P><H><R><E><H><I><L><A><T><G><S><Y><D><E><H><I><L><L><W><D><T><R><N><M><K><Q><P><L><A><D><T><P><V><Q><G><G><V><W><R><I><K><W><H><P><F><H><H><H><L><L><L><A><A><C><M><H><S><G><F><K><I><L><N><C><Q><K><A><M><E><E><R><Q><E><A><T><V><L><T><S><H><T><L><P><D><S><L><V><Y><G><A><D><W><S><W><L><L><F><R><S><L><Q><R><A><P><S><W><S><F><P><S><N><L><G><T><K><T><A><D><L><K><G><A><S><E><L><P><T><P><C><H><E><C><R><E><D><N><D><G><E><G><H><A><R><P><Q><S><G><M><K><P><L><T><E><G><M><R><K><N><G><T><W><L><Q><A><T><A><A><T><T><R><D><C><G><V><N><P><E><E><A><D><S><A><F><S><L><L><A><T><C><S><F><Y><D><H><A><L><H><L><W><E><W><E><G><N>
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).<BOP>
Q9BTV6
Q5JTY5
ZNG1C_HUMAN
Cobalamin synthase W domain-containing protein 3
Homo
<M><L><P><A><V><G><S><V><D><E><E><E><D><P><A><E><E><D><C><P><E><L><V><P><I><E><T><T><Q><S><E><E><E><E><K><S><G><L><G><A><K><I><P><V><T><I><I><T><G><Y><L><G><A><G><K><T><T><L><L><N><Y><I><L><T><E><Q><H><S><K><R><V><A><V><I><L><N><E><S><G><E><G><S><A><L><E><K><S><L><A><V><S><Q><G><G><E><L><Y><E><E><W><L><E><L><R><N><G><C><L><C><C><S><V><K><D><N><G><L><R><A><I><E><N><L><M><Q><K><K><G><K><F><D><D><I><L><L><E><T><T><G><L><A><D><P><G><A><V><A><S><M><F><W><V><D><A><E><L><G><S><D><I><Y><L><D><G><I><I><T><I><V><D><S><K><Y><G><L><K><H><L><T><E><E><K><P><D><G><L><I><N><E><A><T><R><Q><V><A><L><A><D><I><I><L><I><N><K><T><D><L><V><P><E><E><D><V><K><K><L><R><T><T><I><R><S><I><N><G><L><G><Q><I><L><E><T><Q><R><S><R><V><D><L><S><N><V><L><D><L><H><A><F><D><S><L><S><G><I><S><L><Q><K><K><L><Q><H><V><P><G><T><Q><P><H><L><D><Q><S><I><V><T><I><T><F><E><V><P><G><N><A><K><E><E><H><L><N><M><F><I><Q><N><L><L><W><E><K><N><V><R><N><K><D><N><H><C><M><E><V><I><R><L><K><G><L><V><S><I><K><D><K><S><Q><Q><V><I><V><Q><G><V><H><E><L><Y><D><L><E><E><T><P><V><S><W><K><D><D><T><E><R><T><N><R><L><V><L><I><G><R><N><L><D><K><D><I><L><K><Q><L><F><I><A><T><V><T><E><T><E><K><Q><W><T><T><H><F><K><E><D><Q><V><C><T>
Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.<BOP>
Q5JTY5
P18089
ADA2B_HUMAN
Alpha-2B adrenoreceptor
Homo
<M><D><H><Q><D><P><Y><S><V><Q><A><T><A><A><I><A><A><A><I><T><F><L><I><L><F><T><I><F><G><N><A><L><V><I><L><A><V><L><T><S><R><S><L><R><A><P><Q><N><L><F><L><V><S><L><A><A><A><D><I><L><V><A><T><L><I><I><P><F><S><L><A><N><E><L><L><G><Y><W><Y><F><R><R><T><W><C><E><V><Y><L><A><L><D><V><L><F><C><T><S><S><I><V><H><L><C><A><I><S><L><D><R><Y><W><A><V><S><R><A><L><E><Y><N><S><K><R><T><P><R><R><I><K><C><I><I><L><T><V><W><L><I><A><A><V><I><S><L><P><P><L><I><Y><K><G><D><Q><G><P><Q><P><R><G><R><P><Q><C><K><L><N><Q><E><A><W><Y><I><L><A><S><S><I><G><S><F><F><A><P><C><L><I><M><I><L><V><Y><L><R><I><Y><L><I><A><K><R><S><N><R><R><G><P><R><A><K><G><G><P><G><Q><G><E><S><K><Q><P><R><P><D><H><G><G><A><L><A><S><A><K><L><P><A><L><A><S><V><A><S><A><R><E><V><N><G><H><S><K><S><T><G><E><K><E><E><G><E><T><P><E><D><T><G><T><R><A><L><P><P><S><W><A><A><L><P><N><S><G><Q><G><Q><K><E><G><V><C><G><A><S><P><E><D><E><A><E><E><E><E><E><E><E><E><E><E><E><E><C><E><P><Q><A><V><P><V><S><P><A><S><A><C><S><P><P><L><Q><Q><P><Q><G><S><R><V><L><A><T><L><R><G><Q><V><L><L><G><R><G><V><G><A><I><G><G><Q><W><W><R><R><R><A><Q><L><T><R><E><K><R><F><T><F><V><L><A><V><V><I><G><V><F><V><L><C><W><F><P><F><F><F><S><Y><S><L><G><A><I><C><P><K><H><C><K><V><P><H><G><L><F><Q><F><F><F><W><I><G><Y><C><N><S><S><L><N><P><V><I><Y><T><I><F><N><Q><D><F><R><R><A><F><R><R><I><L><C><R><P><W><T><Q><T><A><W>
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.<BOP>
P18089
Q8N695
SC5A8_HUMAN
Solute carrier family 5 member 8
Homo
<M><D><T><P><R><G><I><G><T><F><V><V><W><D><Y><V><V><F><A><G><M><L><V><I><S><A><A><I><G><I><Y><Y><A><F><A><G><G><G><Q><Q><T><S><K><D><F><L><M><G><G><R><R><M><T><A><V><P><V><A><L><S><L><T><A><S><F><M><S><A><V><T><V><L><G><T><P><S><E><V><Y><R><F><G><A><I><F><S><I><F><A><F><T><Y><F><F><V><V><V><I><S><A><E><V><F><L><P><V><F><Y><K><L><G><I><T><S><T><Y><E><Y><L><E><L><R><F><N><K><C><V><R><L><C><G><T><V><L><F><I><V><Q><T><I><L><Y><T><G><I><V><I><Y><A><P><A><L><A><L><N><Q><V><T><G><F><D><L><W><G><A><V><V><A><T><G><V><V><C><T><F><Y><C><T><L><G><G><L><K><A><V><I><W><T><D><V><F><Q><V><G><I><M><V><A><G><F><A><S><V><I><I><Q><A><V><V><M><Q><G><G><I><S><T><I><L><N><D><A><Y><D><G><G><R><L><N><F><W><N><F><N><P><N><P><L><Q><R><H><T><F><W><T><I><I><I><G><G><T><F><T><W><T><S><I><Y><G><V><N><Q><S><Q><V><Q><R><Y><I><S><C><K><S><R><F><Q><A><K><L><S><L><Y><I><N><L><V><G><L><W><A><I><L><T><C><S><V><F><C><G><L><A><L><Y><S><R><Y><H><D><C><D><P><W><T><A><K><K><V><S><A><P><D><Q><L><M><P><Y><L><V><L><D><I><L><Q><D><Y><P><G><L><P><G><L><F><V><A><C><A><Y><S><G><T><L><S><T><V><S><S><S><I><N><A><L><A><A><V><T><V><E><D><L><I><K><P><Y><F><R><S><L><S><E><R><S><L><S><W><I><S><Q><G><M><S><V><V><Y><G><A><L><C><I><G><M><A><A><L><A><S><L><M><G><A><L><L><Q><A><A><L><S><V><F><G><M><V><G><G><P><L><M><G><L><F><A><L><G><I><L><V><P><F><A><N><S><I><G><A><L><V><G><L><M><A><G><F><A><I><S><L><W><V><G><I><G><A><Q><I><Y><P><P><L><P><E><R><T><L><P><L><H><L><D><I><Q><G><C><N><S><T><Y><N><E><T><N><L><M><T><T><T><E><M><P><F><T><T><S><V><F><Q><I><Y><N><V><Q><R><T><P><L><M><D><N><W><Y><S><L><S><Y><L><Y><F><S><T><V><G><T><L><V><T><L><L><V><G><I><L><V><S><L><S><T><G><G><R><K><Q><N><L><D><P><R><Y><I><L><T><K><E><D><F><L><S><N><F><D><I><F><K><K><K><K><H><V><L><S><Y><K><S><H><P><V><E><D><G><G><T><D><N><P><A><F><N><H><I><E><L><N><S><D><Q><S><G><K><S><N><G><T><R><L>
Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient
Q8N695
O43508
TNF12_HUMAN
Tumor necrosis factor ligand superfamily member 12, secreted form
Homo
<M><A><A><R><R><S><Q><R><R><R><G><R><R><G><E><P><G><T><A><L><L><V><P><L><A><L><G><L><G><L><A><L><A><C><L><G><L><L><L><A><V><V><S><L><G><S><R><A><S><L><S><A><Q><E><P><A><Q><E><E><L><V><A><E><E><D><Q><D><P><S><E><L><N><P><Q><T><E><E><S><Q><D><P><A><P><F><L><N><R><L><V><R><P><R><R><S><A><P><K><G><R><K><T><R><A><R><R><A><I><A><A><H><Y><E><V><H><P><R><P><G><Q><D><G><A><Q><A><G><V><D><G><T><V><S><G><W><E><E><A><R><I><N><S><S><S><P><L><R><Y><N><R><Q><I><G><E><F><I><V><T><R><A><G><L><Y><Y><L><Y><C><Q><V><H><F><D><E><G><K><A><V><Y><L><K><L><D><L><L><V><D><G><V><L><A><L><R><C><L><E><E><F><S><A><T><A><A><S><S><L><G><P><Q><L><R><L><C><Q><V><S><G><L><L><A><L><R><P><G><S><S><L><R><I><R><T><L><P><W><A><H><L><K><A><A><P><F><L><T><Y><F><G><L><F><Q><V><H>
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.<BOP>
O43508
D6RCP7
U17LJ_HUMAN
Ubiquitin carboxyl-terminal hydrolase 17-like protein 19
Homo
<M><E><E><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><T><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><K><L><S><S><T><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
D6RCP7
Q96D46
NMD3_HUMAN
60S ribosomal export protein NMD3
Homo
<M><E><Y><M><A><E><S><T><D><R><S><P><G><H><I><L><C><C><E><C><G><V><P><I><S><P><N><P><A><N><I><C><V><A><C><L><R><S><K><V><D><I><S><Q><G><I><P><K><Q><V><S><I><S><F><C><K><Q><C><Q><R><Y><F><Q><P><P><G><T><W><I><Q><C><A><L><E><S><R><E><L><L><A><L><C><L><K><K><I><K><A><P><L><S><K><V><R><L><V><D><A><G><F><V><W><T><E><P><H><S><K><R><L><K><V><K><L><T><I><Q><K><E><V><M><N><G><A><I><L><Q><Q><V><F><V><V><D><Y><V><V><Q><S><Q><M><C><G><D><C><H><R><V><E><A><K><D><F><W><K><A><V><I><Q><V><R><Q><K><T><L><H><K><K><T><F><Y><Y><L><E><Q><L><I><L><K><Y><G><M><H><Q><N><T><L><R><I><K><E><I><H><D><G><L><D><F><Y><Y><S><S><K><Q><H><A><Q><K><M><V><E><F><L><Q><C><T><V><P><C><R><Y><K><A><S><Q><R><L><I><S><Q><D><I><H><S><N><T><Y><N><Y><K><S><T><F><S><V><E><I><V><P><I><C><K><D><N><V><V><C><L><S><P><K><L><A><Q><S><L><G><N><M><N><Q><I><C><V><C><I><R><V><T><S><A><I><H><L><I><D><P><N><T><L><Q><V><A><D><I><D><G><S><T><F><W><S><H><P><F><N><S><L><C><H><P><K><Q><L><E><E><F><I><V><M><E><C><S><I><V><Q><D><I><K><R><A><A><G><A><G><M><I><S><K><K><H><T><L><G><E><V><W><V><Q><K><T><S><E><M><N><T><D><K><Q><Y><F><C><R><T><H><L><G><H><L><L><N><P><G><D><L><V><L><G><F><D><L><A><N><C><N><L><N><D><E><H><V><N><K><M><N><S><D><R><V><P><D><V><V><L><I><K><K><S><Y><D><R><T><K><R><Q><R><R><R><N><W><K><L><K><E><L><A><R><E><R><E><N><M><D><T><D><D><E><R><Q><Y><Q><D><F><L><E><D><L><E><E><D><E><A><I><R><K><N><V><N><I><Y><R><D><S><A><I><P><V><E><S><D><T><D><D><E><G><A><P><R><I><S><L><A><E><M><L><E><D><L><H><I><S><Q><D><A><T><G><E><E><G><A><S><M><L><T>
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.<BOP>
Q96D46