accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
P01889 | HLAB_HUMAN | Human leukocyte antigen B | Homo | <M><L><V><M><A><P><R><T><V><L><L><L><L><S><A><A><L><A><L><T><E><T><W><A><G><S><H><S><M><R><Y><F><Y><T><S><V><S><R><P><G><R><G><E><P><R><F><I><S><V><G><Y><V><D><D><T><Q><F><V><R><F><D><S><D><A><A><S><P><R><E><E><P><R><A><P><W><I><E><Q><E><G><P><E><Y><W><D><R><N><T><Q><I><Y><K><A><Q><A><Q><T><D><R><E><S><L><R><N><L><R><G><Y><Y><N><Q><S><E><A><G><S><H><T><L><Q><S><M><Y><G><C><D><V><G><P><D><G><R><L><L><R><G><H><D><Q><Y><A><Y><D><G><K><D><Y><I><A><L><N><E><D><L><R><S><W><T><A><A><D><T><A><A><Q><I><T><Q><R><K><W><E><A><A><R><E><A><E><Q><R><R><A><Y><L><E><G><E><C><V><E><W><L><R><R><Y><L><E><N><G><K><D><K><L><E><R><A><D><P><P><K><T><H><V><T><H><H><P><I><S><D><H><E><A><T><L><R><C><W><A><L><G><F><Y><P><A><E><I><T><L><T><W><Q><R><D><G><E><D><Q><T><Q><D><T><E><L><V><E><T><R><P><A><G><D><R><T><F><Q><K><W><A><A><V><V><V><P><S><G><E><E><Q><R><Y><T><C><H><V><Q><H><E><G><L><P><K><P><L><T><L><R><W><E><P><S><S><Q><S><T><V><P><I><V><G><I><V><A><G><L><A><V><L><A><V><V><V><I><G><A><V><V><A><A><V><M><C><R><R><K><S><S><G><G><K><G><G><S><Y><S><Q><A><A><C><S><D><S><A><Q><G><S><D><V><S><L><T><A> | Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.<BOP> | P01889 |
Q9BYP9 | KRA99_HUMAN | Ultrahigh sulfur keratin-associated protein 9.9 | Homo | <M><T><H><C><C><S><P><C><C><Q><P><T><C><C><R><T><T><C><C><R><T><T><C><W><K><P><T><T><V><T><T><C><S><S><T><P><C><C><Q><P><S><C><C><V><S><S><C><C><Q><P><C><C><R><P><A><C><C><Q><N><T><C><C><R><T><T><C><C><Q><P><T><C><L><S><S><C><C><G><Q><T><S><C><G><S><S><C><G><Q><S><S><S><C><A><P><V><Y><C><R><R><T><C><Y><Y><P><T><T><V><C><L><P><G><C><L><N><Q><S><C><G><S><S><C><C><Q><P><C><C><R><P><A><C><C><E><T><T><C><C><R><T><T><C><F><Q><P><T><C><V><S><S><C><C><Q><P><S><C><C> | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP> | Q9BYP9 |
A0A3B3IU63 | H2AL3_HUMAN | Histone H2A-like 3 | Homo | <M><A><G><N><K><M><F><C><R><P><R><R><Q><R><L><S><H><S><R><R><A><E><L><Q><F><P><V><S><H><L><E><R><C><L><R><E><S><Q><H><A><R><H><L><S><S><T><T><P><V><F><L><A><G><V><L><E><Y><L><T><A><N><I><L><E><K><V><G><K><E><V><K><N><S><C><R><L><C><I><T><P><E><H><V><K><R><A><L><Q><K><D><E><Q><L><R><W><I><L><E><L><E><D><D><T><H><S><Q><V><E><E><M><P><Q><S><E><E><E><E><E><E><E><E><E><K><E><E><E><M><V><V><L><V><V><M><G><G><R><R><R><R><R><R><R><R><R><R><K><D><S> | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP> | A0A3B3IU63 |
A6NFY7 | SDHF1_HUMAN | LYR motif-containing protein 8 | Homo | <M><S><R><H><S><R><L><Q><R><Q><V><L><S><L><Y><R><D><L><L><R><A><G><R><G><K><P><G><A><E><A><R><V><R><A><E><F><R><Q><H><A><G><L><P><R><S><D><V><L><R><I><E><Y><L><Y><R><R><G><R><R><Q><L><Q><L><L><R><S><G><H><A><T><A><M><G><A><F><V><R><P><R><A><P><T><G><E><P><G><G><V><G><C><Q><P><D><D><G><D><S><P><R><N><P><H><D><S><T><G><A><P><E><T><R><P><D><G><R> | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol . Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants . May act together with SDHAF3 . Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20 .<BOP> | A6NFY7 |
Q8TF39 | ZN483_HUMAN | Zinc finger protein with KRAB and SCAN domains 16 | Homo | <M><Q><A><V><V><P><L><N><K><M><T><A><I><S><P><E><P><Q><T><L><A><S><T><E><Q><N><E><V><P><R><V><V><T><S><G><E><Q><E><A><I><L><R><G><N><A><A><D><A><E><S><F><R><Q><R><F><R><W><F><C><Y><S><E><V><A><G><P><R><K><A><L><S><Q><L><W><E><L><C><N><Q><W><L><R><P><D><I><H><T><K><E><Q><I><L><E><L><L><V><F><E><Q><F><L><T><I><L><P><G><E><I><R><I><W><V><K><S><Q><H><P><E><S><S><E><E><V><V><T><L><I><E><D><L><T><Q><M><L><E><E><K><D><P><V><S><Q><D><S><T><V><S><Q><E><E><N><S><K><E><D><K><M><V><T><V><C><P><N><T><E><S><C><E><S><I><T><L><K><D><V><A><V><N><F><S><R><G><E><W><K><K><L><E><P><F><Q><K><E><L><Y><K><E><V><L><L><E><N><L><R><N><L><E><F><L><D><F><P><V><S><K><L><E><L><I><S><Q><L><K><W><V><E><L><P><W><L><L><E><E><V><S><K><S><S><R><L><D><E><S><A><L><D><K><I><I><E><R><C><L><R><D><D><D><H><G><L><M><E><E><S><Q><Q><Y><C><G><S><S><E><E><D><H><G><N><Q><G><N><S><K><G><R><V><A><Q><N><K><T><L><G><S><G><S><R><G><K><K><F><D><P><D><K><S><P><F><G><H><N><F><K><E><T><S><D><L><I><K><H><L><R><V><Y><L><R><K><K><S><R><R><Y><N><E><S><K><K><P><F><S><F><H><S><D><L><V><L><N><R><K><E><K><T><A><G><E><K><S><R><K><S><N><D><G><G><K><V><L><S><H><S><S><A><L><T><E><H><Q><K><R><Q><K><I><H><L><G><D><R><S><Q><K><C><S><K><C><G><I><I><F><I><R><R><S><T><L><S><R><R><K><T><P><M><C><E><K><C><R><K><D><S><C><Q><E><A><A><L><N><K><D><E><G><N><E><S><G><E><K><T><H><K><C><S><K><C><G><K><A><F><G><Y><S><A><S><L><T><K><H><R><R><I><H><T><G><E><K><P><Y><M><C><N><E><C><G><K><A><F><S><D><S><S><S><L><T><P><H><H><R><T><H><S><G><E><K><P><F><K><C><D><D><C><G><K><G><F><T><L><S><A><H><L><I><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><K><D><C><G><R><P><F><S><D><S><S><S><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><T><C><S><N><C><G><K><S><F><S><H><S><S><S><L><S><K><H><Q><R><I><H><T><G><E><K><P><Y><K><C><G><E><C><G><K><A><F><R><Q><N><S><C><L><T><R><H><Q><R><I><H><T><G><E><K><P><Y><L><C><N><D><C><G><M><T><F><S><H><F><T><S><V><I><Y><H><Q><R><L><H><S><G><E><K><P><Y><K><C><N><Q><C><E><K><A><F><P><T><H><S><L><L><S><R><H><Q><R><I><H><T><G><V><K><P><Y><K><C><K><E><C><G><K><S><F><S><Q><S><S><S><L><N><E><H><H><R><I><H><T><G><E><K><P><Y><E><C><N><Y><C><G><A><T><F><S><R><S><S><I><L><V><E><H><L><K><I><H><T><G><R><R><E><Y><E><C><N><E><C><E><K><T><F><K><S><N><S><G><L><I><R><H><R><G><F><H><S><A><E> | May be involved in transcriptional regulation.<BOP> | Q8TF39 |
Q8N392 | RHG18_HUMAN | Rho-type GTPase-activating protein 18 | Homo | <M><S><W><L><S><S><S><Q><G><V><V><L><T><A><Y><H><P><S><G><K><D><Q><T><V><G><N><S><H><A><K><A><G><E><E><A><T><S><S><R><R><Y><G><Q><Y><T><M><N><Q><E><S><T><T><I><K><V><M><E><K><P><P><F><D><R><S><I><S><Q><D><S><L><D><E><L><S><M><E><D><Y><W><I><E><L><E><N><I><K><K><S><S><E><N><S><Q><E><D><Q><E><V><V><V><V><K><E><P><D><E><G><E><L><E><E><E><W><L><K><E><A><G><L><S><N><L><F><G><E><S><A><G><D><P><Q><E><S><I><V><F><L><S><T><L><T><R><T><Q><A><A><A><V><Q><K><R><V><E><T><V><S><Q><T><L><R><K><K><N><K><Q><Y><Q><I><P><D><V><R><D><I><F><A><Q><Q><R><E><S><K><E><T><A><P><G><G><T><E><S><Q><S><L><R><T><N><E><N><K><Y><Q><G><R><D><D><E><A><S><N><L><V><G><E><E><K><L><I><P><P><E><E><T><P><A><P><E><T><D><I><N><L><E><V><S><F><A><E><Q><A><L><N><Q><K><E><S><S><K><E><K><I><Q><K><S><K><G><D><D><A><T><L><P><S><F><R><L><P><K><D><K><T><G><T><T><R><I><G><D><L><A><P><Q><D><M><K><K><V><C><H><L><A><L><I><E><L><T><A><L><Y><D><V><L><G><I><E><L><K><Q><Q><K><A><V><K><I><K><T><K><D><S><G><L><F><C><V><P><L><T><A><L><L><E><Q><D><Q><R><K><V><P><G><M><R><I><P><L><I><F><Q><K><L><I><S><R><I><E><E><R><G><L><E><T><E><G><L><L><R><I><P><G><A><A><I><R><I><K><N><L><C><Q><E><L><E><A><K><F><Y><E><G><T><F><N><W><E><S><V><K><Q><H><D><A><A><S><L><L><K><L><F><I><R><E><L><P><Q><P><L><L><S><V><E><Y><L><K><A><F><Q><A><V><Q><N><L><P><T><K><K><Q><Q><L><Q><A><L><N><L><L><V><I><L><L><P><D><A><N><R><D><T><L><K><A><L><L><E><F><L><Q><R><V><I><D><N><K><E><K><N><K><M><T><V><M><N><V><A><M><V><M><A><P><N><L><F><M><C><H><A><L><G><L><K><S><S><E><Q><R><E><F><V><M><A><A><G><T><A><N><T><M><H><L><L><I><K><Y><Q><K><L><L><W><T><I><P><K><F><I><V><N><Q><V><R><K><Q><N><T><E><N><H><K><K><D><K><R><A><M><K><K><L><L><K><K><M><A><Y><D><R><E><K><Y><E><K><Q><D><K><S><T><N><D><A><D><V><P><Q><G><V><I><R><V><Q><A><P><H><L><S><K><V><S><M><A><I><Q><L><T><E><E><L><K><A><S><D><V><L><A><R><F><L><S><Q><E><S><G><V><A><Q><T><L><K><K><G><E><V><F><L><Y><E><I><G><G><N><I><G><E><R><C><L><D><D><D><T><Y><M><K><D><L><Y><Q><L><N><P><N><A><E><W><V><I><K><S><K><P><L> | Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state . Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 . Regulates cell shape, spreading, and migration .<BOP> | Q8N392 |
Q9NQ29 | LUC7L_HUMAN | SR+89 | Homo | <M><S><A><Q><A><Q><M><R><A><L><L><D><Q><L><M><G><T><A><R><D><G><D><E><T><R><Q><R><V><K><F><T><D><D><R><V><C><K><S><H><L><L><D><C><C><P><H><D><I><L><A><G><T><R><M><D><L><G><E><C><T><K><I><H><D><L><A><L><R><A><D><Y><E><I><A><S><K><E><R><D><L><F><F><E><L><D><A><M><D><H><L><E><S><F><I><A><E><C><D><R><R><T><E><L><A><K><K><R><L><A><E><T><Q><E><E><I><S><A><E><V><S><A><K><A><E><K><V><H><E><L><N><E><E><I><G><K><L><L><A><K><A><E><Q><L><G><A><E><G><N><V><D><E><S><Q><K><I><L><M><E><V><E><K><V><R><A><K><K><K><E><A><E><E><E><Y><R><N><S><M><P><A><S><S><F><Q><Q><Q><K><L><R><V><C><E><V><C><S><A><Y><L><G><L><H><D><N><D><R><R><L><A><D><H><F><G><G><K><L><H><L><G><F><I><Q><I><R><E><K><L><D><Q><L><R><K><T><V><A><E><K><Q><E><K><R><N><Q><D><R><L><R><R><R><E><E><R><E><R><E><E><R><L><S><R><R><S><G><S><R><T><R><D><R><R><R><S><R><S><R><D><R><R><R><R><R><S><R><S><T><S><R><E><R><R><K><L><S><R><S><R><S><R><D><R><H><R><R><H><R><S><R><S><R><S><H><S><R><G><H><R><R><A><S><R><D><R><S><A><K><Y><K><F><S><R><E><R><A><S><R><E><E><S><W><E><S><G><R><S><E><R><G><P><P><D><W><R><L><E><S><S><N><G><K><M><A><S><R><R><S><E><E><K><E><A><G><E><I> | May bind to RNA via its Arg/Ser-rich domain.<BOP> | Q9NQ29 |
Q8WZ60 | KLHL6_HUMAN | Kelch-like protein 6 | Homo | <M><L><M><A><G><Q><R><G><A><W><T><M><G><D><V><V><E><K><S><L><E><G><P><L><A><P><S><T><D><E><P><S><Q><K><T><G><D><L><V><E><I><L><N><G><E><K><V><K><F><D><D><A><G><L><S><L><I><L><Q><N><G><L><E><T><L><R><M><E><N><A><L><T><D><V><I><L><C><V><D><I><Q><E><F><S><C><H><R><V><V><L><A><A><A><S><N><Y><F><R><A><M><F><C><N><D><L><K><E><K><Y><E><K><R><I><I><I><K><G><V><D><A><E><T><M><H><T><L><L><D><Y><T><Y><T><S><K><A><L><I><T><K><Q><N><V><Q><R><V><L><E><A><A><N><L><F><Q><F><L><R><M><V><D><A><C><A><S><F><L><T><E><A><L><N><P><E><N><C><V><G><I><L><R><L><A><D><T><H><S><L><D><S><L><K><K><Q><V><Q><S><Y><I><I><Q><N><F><V><Q><I><L><N><S><E><E><F><L><D><L><P><V><D><T><L><H><H><I><L><K><S><D><D><L><Y><V><T><E><E><A><Q><V><F><E><T><V><M><S><W><V><R><H><K><P><S><E><R><L><C><L><L><P><Y><V><L><E><N><V><R><L><P><L><L><D><P><W><Y><F><V><E><T><V><E><A><D><P><L><I><R><Q><C><P><E><V><F><P><L><L><Q><E><A><R><M><Y><H><L><S><G><N><E><I><I><S><E><R><T><K><P><R><M><H><E><F><Q><S><E><V><F><M><I><I><G><G><C><T><K><D><E><R><F><V><A><E><V><T><C><L><D><P><L><R><R><S><R><L><E><V><A><K><L><P><L><T><E><H><E><L><E><S><E><N><K><K><W><V><E><F><A><C><V><T><L><K><N><E><V><Y><I><S><G><G><K><E><T><Q><H><D><V><W><K><Y><N><S><S><I><N><K><W><I><Q><I><E><Y><L><N><I><G><R><W><R><H><K><M><V><V><L><G><G><K><V><Y><V><I><G><G><F><D><G><L><Q><R><I><N><N><V><E><T><Y><D><P><F><H><N><C><W><S><E><A><A><P><L><L><V><H><V><S><S><F><A><A><T><S><H><K><K><K><L><Y><V><I><G><G><G><P><N><G><K><L><A><T><D><K><T><Q><C><Y><D><P><S><T><N><K><W><S><L><K><A><A><M><P><V><E><A><K><C><I><N><A><V><S><F><R><D><R><I><Y><V><V><G><G><A><M><R><A><L><Y><A><Y><S><P><L><E><D><S><W><C><L><V><T><Q><L><S><H><E><R><A><S><C><G><I><A><P><C><N><N><R><L><Y><I><T><G><G><R><D><E><K><N><E><V><I><A><T><V><L><C><W><D><P><E><A><Q><K><L><T><E><E><C><V><L><P><R><G><V><S><H><H><G><S><V><T><I><R><K><S><Y><T><H><I><R><R><I><V><P><G><A><V><S><V> | Involved in B-lymphocyte antigen receptor signaling and germinal center formation.<BOP> | Q8WZ60 |
P16452 | EPB42_HUMAN | Erythrocyte membrane protein band 4.2 | Homo | <M><G><Q><A><L><G><I><K><S><C><D><F><Q><A><A><R><N><N><E><E><H><H><T><K><A><L><S><S><R><R><L><F><V><R><R><G><Q><P><F><T><I><I><L><Y><F><R><A><P><V><R><A><F><L><P><A><L><K><K><V><A><L><T><A><Q><T><G><E><Q><P><S><K><I><N><R><T><Q><A><T><F><P><I><S><S><L><G><D><R><K><W><W><S><A><V><V><E><E><R><D><A><Q><S><W><T><I><S><V><T><T><P><A><D><A><V><I><G><H><Y><S><L><L><L><Q><V><S><G><R><K><Q><L><L><L><G><Q><F><T><L><L><F><N><P><W><N><R><E><D><A><V><F><L><K><N><E><A><Q><R><M><E><Y><L><L><N><Q><N><G><L><I><Y><L><G><T><A><D><C><I><Q><A><E><S><W><D><F><G><Q><F><E><G><D><V><I><D><L><S><L><R><L><L><S><K><D><K><Q><V><E><K><W><S><Q><P><V><H><V><A><R><V><L><G><A><L><L><H><F><L><K><E><Q><R><V><L><P><T><P><Q><T><Q><A><T><Q><E><G><A><L><L><N><K><R><R><G><S><V><P><I><L><R><Q><W><L><T><G><R><G><R><P><V><Y><D><G><Q><A><W><V><L><A><A><V><A><C><T><V><L><R><C><L><G><I><P><A><R><V><V><T><T><F><A><S><A><Q><G><T><G><G><R><L><L><I><D><E><Y><Y><N><E><E><G><L><Q><N><G><E><G><Q><R><G><R><I><W><I><F><Q><T><S><T><E><C><W><M><T><R><P><A><L><P><Q><G><Y><D><G><W><Q><I><L><H><P><S><A><P><N><G><G><G><V><L><G><S><C><D><L><V><P><V><R><A><V><K><E><G><T><L><G><L><T><P><A><V><S><D><L><F><A><A><I><N><A><S><C><V><V><W><K><C><C><E><D><G><T><L><E><L><T><D><S><N><T><K><Y><V><G><N><N><I><S><T><K><G><V><G><S><D><R><C><E><D><I><T><Q><N><Y><K><Y><P><E><G><S><L><Q><E><K><E><V><L><E><R><V><E><K><E><K><M><E><R><E><K><D><N><G><I><R><P><P><S><L><E><T><A><S><P><L><Y><L><L><L><K><A><P><S><S><L><P><L><R><G><D><A><Q><I><S><V><T><L><V><N><H><S><E><Q><E><K><A><V><Q><L><A><I><G><V><Q><A><V><H><Y><N><G><V><L><A><A><K><L><W><R><K><K><L><H><L><T><L><S><A><N><L><E><K><I><I><T><I><G><L><F><F><S><N><F><E><R><N><P><P><E><N><T><F><L><R><L><T><A><M><A><T><H><S><E><S><N><L><S><C><F><A><Q><E><D><I><A><I><C><R><P><H><L><A><I><K><M><P><E><K><A><E><Q><Y><Q><P><L><T><A><S><V><S><L><Q><N><S><L><D><A><P><M><E><D><C><V><I><S><I><L><G><R><G><L><I><H><R><E><R><S><Y><R><F><R><S><V><W><P><E><N><T><M><C><A><K><F><Q><F><T><P><T><H><V><G><L><Q><R><L><T><V><E><V><D><C><N><M><F><Q><N><L><T><N><Y><K><S><V><T><V><V><A><P><E><L><S><A> | Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.<BOP> | P16452 |
O95433 | AHSA1_HUMAN | p38 | Homo | <M><A><K><W><G><E><G><D><P><R><W><I><V><E><E><R><A><D><A><T><N><V><N><N><W><H><W><T><E><R><D><A><S><N><W><S><T><D><K><L><K><T><L><F><L><A><V><Q><V><Q><N><E><E><G><K><C><E><V><T><E><V><S><K><L><D><G><E><A><S><I><N><N><R><K><G><K><L><I><F><F><Y><E><W><S><V><K><L><N><W><T><G><T><S><K><S><G><V><Q><Y><K><G><H><V><E><I><P><N><L><S><D><E><N><S><V><D><E><V><E><I><S><V><S><L><A><K><D><E><P><D><T><N><L><V><A><L><M><K><E><E><G><V><K><L><L><R><E><A><M><G><I><Y><I><S><T><L><K><T><E><F><T><Q><G><M><I><L><P><T><M><N><G><E><S><V><D><P><V><G><Q><P><A><L><K><T><E><E><R><K><A><K><P><A><P><S><K><T><Q><A><R><P><V><G><V><K><I><P><T><C><K><I><T><L><K><E><T><F><L><T><S><P><E><E><L><Y><R><V><F><T><T><Q><E><L><V><Q><A><F><T><H><A><P><A><T><L><E><A><D><R><G><G><K><F><H><M><V><D><G><N><V><S><G><E><F><T><D><L><V><P><E><K><H><I><V><M><K><W><R><F><K><S><W><P><E><G><H><F><A><T><I><T><L><T><F><I><D><K><N><G><E><T><E><L><C><M><E><G><R><G><I><P><A><P><E><E><E><R><T><R><Q><G><W><Q><R><Y><Y><F><E><G><I><K><Q><T><F><G><Y><G><A><R><L><F> | Acts as a co-chaperone of HSP90AA1 . Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity . Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins .<BOP> | O95433 |
Q969Q4 | ARL11_HUMAN | ADP-ribosylation factor-like tumor suppressor protein 1 | Homo | <M><G><S><V><N><S><R><G><H><K><A><E><A><Q><V><V><M><M><G><L><D><S><A><G><K><T><T><L><L><Y><K><L><K><G><H><Q><L><V><E><T><L><P><T><V><G><F><N><V><E><P><L><K><A><P><G><H><V><S><L><T><L><W><D><V><G><G><Q><A><P><L><R><A><S><W><K><D><Y><L><E><G><T><D><I><L><V><Y><V><L><D><S><T><D><E><A><R><L><P><E><S><A><A><E><L><T><E><V><L><N><D><P><N><M><A><G><V><P><F><L><V><L><A><N><K><Q><E><A><P><D><A><L><P><L><L><K><I><R><N><R><L><S><L><E><R><F><Q><D><H><C><W><E><L><R><G><C><S><A><L><T><G><E><G><L><P><E><A><L><Q><S><L><W><S><L><L><K><S><R><S><C><M><C><L><Q><A><R><A><H><G><A><E><R><G><D><S><K><R><S> | May play a role in apoptosis. May act as a tumor suppressor.<BOP> | Q969Q4 |
Q9Y5J6 | T10B_HUMAN | TIMM10B | Homo | <M><E><R><Q><Q><Q><Q><Q><Q><Q><L><R><N><L><R><D><F><L><L><V><Y><N><R><M><T><E><L><C><F><Q><R><C><V><P><S><L><H><H><R><A><L><D><A><E><E><E><A><C><L><H><S><C><A><G><K><L><I><H><S><N><H><R><L><M><A><A><Y><V><Q><L><M><P><A><L><V><Q><R><R><I><A><D><Y><E><A><A><S><A><V><P><G><V><A><A><E><Q><P><G><V><S><P><S><G><S> | Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.<BOP> | Q9Y5J6 |
A0A0A0MT70 | TJB26_HUMAN | T cell receptor beta joining 2-6 | Homo | <S><G><A><N><V><L><T><F><G><A><G><S><R><L><T><V><L> | J region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A0A0MT70 |
Q13283 | G3BP1_HUMAN | GAP SH3 domain-binding protein 1 | Homo | <M><V><M><E><K><P><S><P><L><L><V><G><R><E><F><V><R><Q><Y><Y><T><L><L><N><Q><A><P><D><M><L><H><R><F><Y><G><K><N><S><S><Y><V><H><G><G><L><D><S><N><G><K><P><A><D><A><V><Y><G><Q><K><E><I><H><R><K><V><M><S><Q><N><F><T><N><C><H><T><K><I><R><H><V><D><A><H><A><T><L><N><D><G><V><V><V><Q><V><M><G><L><L><S><N><N><N><Q><A><L><R><R><F><M><Q><T><F><V><L><A><P><E><G><S><V><A><N><K><F><Y><V><H><N><D><I><F><R><Y><Q><D><E><V><F><G><G><F><V><T><E><P><Q><E><E><S><E><E><E><V><E><E><P><E><E><R><Q><Q><T><P><E><V><V><P><D><D><S><G><T><F><Y><D><Q><A><V><V><S><N><D><M><E><E><H><L><E><E><P><V><A><E><P><E><P><D><P><E><P><E><P><E><Q><E><P><V><S><E><I><Q><E><E><K><P><E><P><V><L><E><E><T><A><P><E><D><A><Q><K><S><S><S><P><A><P><A><D><I><A><Q><T><V><Q><E><D><L><R><T><F><S><W><A><S><V><T><S><K><N><L><P><P><S><G><A><V><P><V><T><G><I><P><P><H><V><V><K><V><P><A><S><Q><P><R><P><E><S><K><P><E><S><Q><I><P><P><Q><R><P><Q><R><D><Q><R><V><R><E><Q><R><I><N><I><P><P><Q><R><G><P><R><P><I><R><E><A><G><E><Q><G><D><I><E><P><R><R><M><V><R><H><P><D><S><H><Q><L><F><I><G><N><L><P><H><E><V><D><K><S><E><L><K><D><F><F><Q><S><Y><G><N><V><V><E><L><R><I><N><S><G><G><K><L><P><N><F><G><F><V><V><F><D><D><S><E><P><V><Q><K><V><L><S><N><R><P><I><M><F><R><G><E><V><R><L><N><V><E><E><K><K><T><R><A><A><R><E><G><D><R><R><D><N><R><L><R><G><P><G><G><P><R><G><G><L><G><G><G><M><R><G><P><P><R><G><G><M><V><Q><K><P><G><F><G><V><G><R><G><L><A><P><R><Q> | ATP- and magnesium-dependent helicase that plays an essential role in innate immunity . Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA . In addition, plays an essential role in stress granule formation . Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends . Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency . Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA . Phosphorylation-dependent sequence-specific endoribonuclease in vitro . Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR .<BOP> | Q13283 |
O94903 | PLPHP_HUMAN | Pyridoxal phosphate-binding protein | Homo | <M><W><R><A><G><S><M><S><A><E><L><G><V><G><C><A><L><R><A><V><N><E><R><V><Q><Q><A><V><A><R><R><P><R><D><L><P><A><I><Q><P><R><L><V><A><V><S><K><T><K><P><A><D><M><V><I><E><A><Y><G><H><G><Q><R><T><F><G><E><N><Y><V><Q><E><L><L><E><K><A><S><N><P><K><I><L><S><L><C><P><E><I><K><W><H><F><I><G><H><L><Q><K><Q><N><V><N><K><L><M><A><V><P><N><L><F><M><L><E><T><V><D><S><V><K><L><A><D><K><V><N><S><S><W><Q><R><K><G><S><P><E><R><L><K><V><M><V><Q><I><N><T><S><G><E><E><S><K><H><G><L><P><P><S><E><T><I><A><I><V><E><H><I><N><A><K><C><P><N><L><E><F><V><G><L><M><T><I><G><S><F><G><H><D><L><S><Q><G><P><N><P><D><F><Q><L><L><L><S><L><R><E><E><L><C><K><K><L><N><I><P><A><D><Q><V><E><L><S><M><G><M><S><A><D><F><Q><H><A><V><E><V><G><S><T><N><V><R><I><G><S><T><I><F><G><E><R><D><Y><S><K><K><P><T><P><D><K><C><A><A><D><V><K><A><P><L><E><V><A><Q><E><H> | Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.<BOP> | O94903 |
Q7RTT5 | SSX7_HUMAN | Protein SSX7 | Homo | <M><N><G><D><D><A><F><A><R><R><P><R><A><G><A><Q><I><P><E><K><I><Q><K><S><F><D><D><I><A><K><Y><F><S><K><K><E><W><E><K><M><K><S><L><E><K><I><S><Y><V><Y><M><K><R><K><Y><E><A><M><T><K><L><G><F><K><A><T><L><P><P><F><M><H><N><T><G><A><T><D><L><Q><G><N><D><F><D><N><D><R><N><Q><G><N><Q><V><E><R><P><Q><M><T><F><C><R><L><Q><R><I><F><P><K><I><M><P><K><K><P><A><E><E><G><N><D><S><K><G><V><P><E><A><S><G><S><Q><N><D><G><K><H><L><C><P><P><G><K><P><S><T><S><E><K><I><N><K><T><S><G><P><K><R><G><K><H><A><W><T><H><R><L><R><E><R><K><Q><L><V><I><Y><E><E><I><S><D><P><E><E><D><D><E> | Could act as a modulator of transcription.<BOP> | Q7RTT5 |
P24387 | CRHBP_HUMAN | Corticotropin-releasing hormone-binding protein | Homo | <M><S><P><N><F><K><L><Q><C><H><F><I><L><I><F><L><T><A><L><R><G><E><S><R><Y><L><E><L><R><E><A><A><D><Y><D><P><F><L><L><F><S><A><N><L><K><R><E><L><A><G><E><Q><P><Y><R><R><A><L><R><C><L><D><M><L><S><L><Q><G><Q><F><T><F><T><A><D><R><P><Q><L><H><C><A><A><F><F><I><S><E><P><E><E><F><I><T><I><H><Y><D><Q><V><S><I><D><C><Q><G><G><D><F><L><K><V><F><D><G><W><I><L><K><G><E><K><F><P><S><S><Q><D><H><P><L><P><S><A><E><R><Y><I><D><F><C><E><S><G><L><S><R><R><S><I><R><S><S><Q><N><V><A><M><I><F><F><R><V><H><E><P><G><N><G><F><T><L><T><I><K><T><D><P><N><L><F><P><C><N><V><I><S><Q><T><P><N><G><K><F><T><L><V><V><P><H><Q><H><R><N><C><S><F><S><I><I><Y><P><V><V><I><K><I><S><D><L><T><L><G><H><V><N><G><L><Q><L><K><K><S><S><A><G><C><E><G><I><G><D><F><V><E><L><L><G><G><T><G><L><D><P><S><K><M><T><P><L><A><D><L><C><Y><P><F><H><G><P><A><Q><M><K><V><G><C><D><N><T><V><V><R><M><V><S><S><G><K><H><V><N><R><V><T><F><E><Y><R><Q><L><E><P><Y><E><L><E><N><P><N><G><N><S><I><G><E><F><C><L><S><G><L> | Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.<BOP> | P24387 |
P62312 | LSM6_HUMAN | U6 snRNA-associated Sm-like protein LSm6 | Homo | <M><S><L><R><K><Q><T><P><S><D><F><L><K><Q><I><I><G><R><P><V><V><V><K><L><N><S><G><V><D><Y><R><G><V><L><A><C><L><D><G><Y><M><N><I><A><L><E><Q><T><E><E><Y><V><N><G><Q><L><K><N><K><Y><G><D><A><F><I><R><G><N><N><V><L><Y><I><S><T><Q><K><R><R><M> | Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable).<BOP> | P62312 |
P49771 | FLT3L_HUMAN | SL cytokine | Homo | <M><T><V><L><A><P><A><W><S><P><T><T><Y><L><L><L><L><L><L><L><S><S><G><L><S><G><T><Q><D><C><S><F><Q><H><S><P><I><S><S><D><F><A><V><K><I><R><E><L><S><D><Y><L><L><Q><D><Y><P><V><T><V><A><S><N><L><Q><D><E><E><L><C><G><G><L><W><R><L><V><L><A><Q><R><W><M><E><R><L><K><T><V><A><G><S><K><M><Q><G><L><L><E><R><V><N><T><E><I><H><F><V><T><K><C><A><F><Q><P><P><P><S><C><L><R><F><V><Q><T><N><I><S><R><L><L><Q><E><T><S><E><Q><L><V><A><L><K><P><W><I><T><R><Q><N><F><S><R><C><L><E><L><Q><C><Q><P><D><S><S><T><L><P><P><P><W><S><P><R><P><L><E><A><T><A><P><T><A><P><Q><P><P><L><L><L><L><L><L><L><P><V><G><L><L><L><L><A><A><A><W><C><L><H><W><Q><R><T><R><R><R><T><P><R><P><G><E><Q><V><P><P><V><P><S><P><Q><D><L><L><L><V><E><H> | Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.<BOP> | P49771 |
Q8NH02 | O2T29_HUMAN | Olfactory receptor 2T29 | Homo | <M><A><N><I><T><R><M><A><N><H><T><G><R><L><D><F><I><L><M><G><L><F><R><Q><S><K><H><P><A><L><L><S><V><V><I><F><V><V><F><L><K><A><L><S><G><N><A><V><L><I><L><L><I><H><C><D><A><H><L><H><S><P><M><Y><F><F><I><S><Q><L><S><L><M><D><M><A><Y><I><S><V><T><V><P><K><M><L><L><D><Q><V><M><G><V><N><K><V><S><A><P><E><C><G><M><Q><M><F><L><Y><L><T><L><A><G><S><E><F><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><P><V><L><M><N><H><R><V><C><L><F><L><A><S><G><C><W><F><L><G><S><V><D><G><F><M><L><T><P><I><T><M><S><F><P><F><C><R><S><W><E><I><H><H><F><F><C><E><V><P><A><V><T><I><L><S><C><S><D><T><S><L><Y><E><T><L><M><Y><L><C><C><V><L><M><L><L><I><P><V><T><I><I><S><S><S><Y><L><L><I><L><L><T><V><H><R><M><N><S><A><E><G><R><K><K><A><F><A><T><C><S><S><H><L><T><V><V><I><L><F><Y><G><A><A><V><Y><T><Y><M><L><P><S><S><Y><H><T><P><E><K><D><M><M><V><S><V><F><Y><T><I><L><T><P><V><L><N><P><L><I><Y><S><L><R><N><K><D><V><M><G><A><L><K><K><M><L><T><V><R><F><V><L> | Odorant receptor.<BOP> | Q8NH02 |
Q9P121 | NTRI_HUMAN | IgLON family member 2 | Homo | <M><G><V><C><G><Y><L><F><L><P><W><K><C><L><V><V><V><S><L><R><L><L><F><L><V><P><T><G><V><P><V><R><S><G><D><A><T><F><P><K><A><M><D><N><V><T><V><R><Q><G><E><S><A><T><L><R><C><T><I><D><N><R><V><T><R><V><A><W><L><N><R><S><T><I><L><Y><A><G><N><D><K><W><C><L><D><P><R><V><V><L><L><S><N><T><Q><T><Q><Y><S><I><E><I><Q><N><V><D><V><Y><D><E><G><P><Y><T><C><S><V><Q><T><D><N><H><P><K><T><S><R><V><H><L><I><V><Q><V><S><P><K><I><V><E><I><S><S><D><I><S><I><N><E><G><N><N><I><S><L><T><C><I><A><T><G><R><P><E><P><T><V><T><W><R><H><I><S><P><K><A><V><G><F><V><S><E><D><E><Y><L><E><I><Q><G><I><T><R><E><Q><S><G><D><Y><E><C><S><A><S><N><D><V><A><A><P><V><V><R><R><V><K><V><T><V><N><Y><P><P><Y><I><S><E><A><K><G><T><G><V><P><V><G><Q><K><G><T><L><Q><C><E><A><S><A><V><P><S><A><E><F><Q><W><Y><K><D><D><K><R><L><I><E><G><K><K><G><V><K><V><E><N><R><P><F><L><S><K><L><I><F><F><N><V><S><E><H><D><Y><G><N><Y><T><C><V><A><S><N><K><L><G><H><T><N><A><S><I><M><L><F><G><P><G><A><V><S><E><V><S><N><G><T><S><R><R><A><G><C><V><W><L><L><P><L><L><V><L><H><L><L><L><K><F> | Neural cell adhesion molecule.<BOP> | Q9P121 |
P55001 | MFAP2_HUMAN | Microfibril-associated glycoprotein 1 | Homo | <M><R><A><A><Y><L><F><L><L><F><L><P><A><G><L><L><A><Q><G><Q><Y><D><L><D><P><L><P><P><F><P><D><H><V><Q><Y><T><H><Y><S><D><Q><I><D><N><P><D><Y><Y><D><Y><Q><E><V><T><P><R><P><S><E><E><Q><F><Q><F><Q><S><Q><Q><Q><V><Q><Q><E><V><I><P><A><P><T><P><E><P><G><N><A><E><L><E><P><T><E><P><G><P><L><D><C><R><E><E><Q><Y><P><C><T><R><L><Y><S><I><H><R><P><C><K><Q><C><L><N><E><V><C><F><Y><S><L><R><R><V><Y><V><I><N><K><E><I><C><V><R><T><V><C><A><H><E><E><L><L><R><A><D><L><C><R><D><K><F><S><K><C><G><V><M><A><S><S><G><L><C><Q><S><V><A><A><S><C><A><R><S><C><G><S><C> | Component of the elastin-associated microfibrils.<BOP> | P55001 |
Q96CB9 | NSUN4_HUMAN | NOL1/NOP2/Sun domain family member 4 | Homo | <M><A><A><L><T><L><R><G><V><R><E><L><L><K><R><V><D><L><A><T><V><P><R><R><H><R><Y><K><K><K><W><A><A><T><E><P><K><F><P><A><V><R><L><A><L><Q><N><F><D><M><T><Y><S><V><Q><F><G><D><L><W><P><S><I><R><V><S><L><L><S><E><Q><K><Y><G><A><L><V><N><N><F><A><A><W><D><H><V><S><A><K><L><E><Q><L><S><A><K><D><F><V><N><E><A><I><S><H><W><E><L><Q><S><E><G><G><Q><S><A><A><P><S><P><A><S><W><A><C><S><P><N><L><R><C><F><T><F><D><R><G><D><I><S><R><F><P><P><A><R><P><G><S><L><G><V><M><E><Y><Y><L><M><D><A><A><S><L><L><P><V><L><A><L><G><L><Q><P><G><D><I><V><L><D><L><C><A><A><P><G><G><K><T><L><A><L><L><Q><T><G><C><C><R><N><L><A><A><N><D><L><S><P><S><R><I><A><R><L><Q><K><I><L><H><S><Y><V><P><E><E><I><R><D><G><N><Q><V><R><V><T><S><W><D><G><R><K><W><G><E><L><E><G><D><T><Y><D><R><V><L><V><D><V><P><C><T><T><D><R><H><S><L><H><E><E><E><N><N><I><F><K><R><S><R><K><K><E><R><Q><I><L><P><V><L><Q><V><Q><L><L><A><A><G><L><L><A><T><K><P><G><G><H><V><V><Y><S><T><C><S><L><S><H><L><Q><N><E><Y><V><V><Q><G><A><I><E><L><L><A><N><Q><Y><S><I><Q><V><Q><V><E><D><L><T><H><F><R><R><V><F><M><D><T><F><C><F><F><S><S><C><Q><V><G><E><L><V><I><P><N><L><M><A><N><F><G><P><M><Y><F><C><K><M><R><R><L><T> | Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.<BOP> | Q96CB9 |
A0A0A0MS01 | TVG10_HUMAN | Probable non-functional T cell receptor gamma variable 10 | Homo | <M><S><L><L><E><A><F><A><F><S><S><W><A><L><G><L><G><L><S><K><V><E><Q><F><Q><L><S><I><S><T><E><V><K><K><S><I><D><I><P><C><K><I><S><S><T><R><F><E><T><D><V><I><H><W><Y><R><Q><K><P><N><Q><A><L><E><H><L><I><Y><I><V><S><T><K><S><A><A><R><R><S><M><G><K><T><S><N><K><V><E><A><R><K><N><S><Q><T><L><T><S><I><L><T><I><K><S><V><E><K><E><D><M><A><V><Y><Y><C><A><A><W><D> | Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) gamma chain . Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair . Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLC | A0A0A0MS01 |
P05937 | CALB1_HUMAN | Vitamin D-dependent calcium-binding protein, avian-type | Homo | <M><A><E><S><H><L><Q><S><S><L><I><T><A><S><Q><F><F><E><I><W><L><H><F><D><A><D><G><S><G><Y><L><E><G><K><E><L><Q><N><L><I><Q><E><L><Q><Q><A><R><K><K><A><G><L><E><L><S><P><E><M><K><T><F><V><D><Q><Y><G><Q><R><D><D><G><K><I><G><I><V><E><L><A><H><V><L><P><T><E><E><N><F><L><L><L><F><R><C><Q><Q><L><K><S><C><E><E><F><M><K><T><W><R><K><Y><D><T><D><H><S><G><F><I><E><T><E><E><L><K><N><F><L><K><D><L><L><E><K><A><N><K><T><V><D><D><T><K><L><A><E><Y><T><D><L><M><L><K><L><F><D><S><N><N><D><G><K><L><E><L><T><E><M><A><R><L><L><P><V><Q><E><N><F><L><L><K><F><Q><G><I><K><M><C><G><K><E><F><N><K><A><F><E><L><Y><D><Q><D><G><N><G><Y><I><D><E><N><E><L><D><A><L><L><K><D><L><C><E><K><N><K><Q><D><L><D><I><N><N><I><T><T><Y><K><K><N><I><M><A><L><S><D><G><G><K><L><Y><R><T><D><L><A><L><I><L><C><A><G><D><N> | Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.<BOP> | P05937 |
Q9NRP2 | COXM2_HUMAN | COX assembly mitochondrial protein 2 homolog | Homo | <M><H><P><D><L><S><P><H><L><H><T><E><E><C><N><V><L><I><N><L><L><K><E><C><H><K><N><H><N><I><L><K><F><F><G><Y><C><N><D><V><D><R><E><L><R><K><C><L><K><N><E><Y><V><E><N><R><T><K><S><R><E><H><G><I><A><M><R><K><K><L><F><N><P><P><E><E><S><E><K> | May be involved in cytochrome c oxidase biogenesis.<BOP> | Q9NRP2 |
Q9BYG0 | B3GN5_HUMAN | UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5 | Homo | <M><R><M><L><V><S><G><R><R><V><K><K><W><Q><L><I><I><Q><L><F><A><T><C><F><L><A><S><L><M><F><F><W><E><P><I><D><N><H><I><V><S><H><M><K><S><Y><S><Y><R><Y><L><I><N><S><Y><D><F><V><N><D><T><L><S><L><K><H><T><S><A><G><P><R><Y><Q><Y><L><I><N><H><K><E><K><C><Q><A><Q><D><V><L><L><L><L><F><V><K><T><A><P><E><N><Y><D><R><R><S><G><I><R><R><T><W><G><N><E><N><Y><V><R><S><Q><L><N><A><N><I><K><T><L><F><A><L><G><T><P><N><P><L><E><G><E><E><L><Q><R><K><L><A><W><E><D><Q><R><Y><N><D><I><I><Q><Q><D><F><V><D><S><F><Y><N><L><T><L><K><L><L><M><Q><F><S><W><A><N><T><Y><C><P><H><A><K><F><L><M><T><A><D><D><D><I><F><I><H><M><P><N><L><I><E><Y><L><Q><S><L><E><Q><I><G><V><Q><D><F><W><I><G><R><V><H><R><G><A><P><P><I><R><D><K><S><S><K><Y><Y><V><S><Y><E><M><Y><Q><W><P><A><Y><P><D><Y><T><A><G><A><A><Y><V><I><S><G><D><V><A><A><K><V><Y><E><A><S><Q><T><L><N><S><S><L><Y><I><D><D><V><F><M><G><L><C><A><N><K><I><G><I><V><P><Q><D><H><V><F><F><S><G><E><G><K><T><P><Y><H><P><C><I><Y><E><K><M><M><T><S><H><G><H><L><E><D><L><Q><D><L><W><K><N><A><T><D><P><K><V><K><T><I><S><K><G><F><F><G><Q><I><Y><C><R><L><M><K><I><I><L><L><C><K><I><S><Y><V><D><T><Y><P><C><R><A><A><F><I> | Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.<BOP> | Q9BYG0 |
Q9Y2I2 | NTNG1_HUMAN | Laminet-1 | Homo | <M><Y><L><S><R><F><L><S><I><H><A><L><W><V><T><V><S><S><V><M><Q><P><Y><P><L><V><W><G><H><Y><D><L><C><K><T><Q><I><Y><T><E><E><G><K><V><W><D><Y><M><A><C><Q><P><E><S><T><D><M><T><K><Y><L><K><V><K><L><D><P><P><D><I><T><C><G><D><P><P><E><T><F><C><A><M><G><N><P><Y><M><C><N><N><E><C><D><A><S><T><P><E><L><A><H><P><P><E><L><M><F><D><F><E><G><R><H><P><S><T><F><W><Q><S><A><T><W><K><E><Y><P><K><P><L><Q><V><N><I><T><L><S><W><S><K><T><I><E><L><T><D><N><I><V><I><T><F><E><S><G><R><P><D><Q><M><I><L><E><K><S><L><D><Y><G><R><T><W><Q><P><Y><Q><Y><Y><A><T><D><C><L><D><A><F><H><M><D><P><K><S><V><K><D><L><S><Q><H><T><V><L><E><I><I><C><T><E><E><Y><S><T><G><Y><T><T><N><S><K><I><I><H><F><E><I><K><D><R><F><A><F><F><A><G><P><R><L><R><N><M><A><S><L><Y><G><Q><L><D><T><T><K><K><L><R><D><F><F><T><V><T><D><L><R><I><R><L><L><R><P><A><V><G><E><I><F><V><D><E><L><H><L><A><R><Y><F><Y><A><I><S><D><I><K><V><R><G><R><C><K><C><N><L><H><A><T><V><C><V><Y><D><N><S><K><L><T><C><E><C><E><H><N><T><T><G><P><D><C><G><K><C><K><K><N><Y><Q><G><R><P><W><S><P><G><S><Y><L><P><I><P><K><G><T><A><N><T><C><I><P><S><I><S><S><I><G><N><C><E><C><F><G><H><S><N><R><C><S><Y><I><D><L><L><N><T><V><I><C><V><S><C><K><H><N><T><R><G><Q><H><C><E><L><C><R><L><G><Y><F><R><N><A><S><A><Q><L><D><D><E><N><V><C><I><E><C><Y><C><N><P><L><G><S><I><H><D><R><C><N><G><S><G><F><C><E><C><K><T><G><T><T><G><P><K><C><D><E><C><L><P><G><N><S><W><H><Y><G><C><Q><P><N><V><C><D><N><E><L><L><H><C><Q><N><G><G><T><C><H><N><N><V><R><C><L><C><P><A><A><Y><T><G><I><L><C><E><K><L><R><C><E><E><A><G><S><C><G><S><D><S><G><Q><G><A><P><P><H><G><S><P><A><L><L><L><L><T><T><L><L><G><T><A><S><P><L><V><F> | Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.<BOP> | Q9Y2I2 |
Q9NZL9 | MAT2B_HUMAN | Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase | Homo | <M><V><G><R><E><K><E><L><S><I><H><F><V><P><G><S><C><R><L><V><E><E><E><V><N><I><P><N><R><R><V><L><V><T><G><A><T><G><L><L><G><R><A><V><H><K><E><F><Q><Q><N><N><W><H><A><V><G><C><G><F><R><R><A><R><P><K><F><E><Q><V><N><L><L><D><S><N><A><V><H><H><I><I><H><D><F><Q><P><H><V><I><V><H><C><A><A><E><R><R><P><D><V><V><E><N><Q><P><D><A><A><S><Q><L><N><V><D><A><S><G><N><L><A><K><E><A><A><A><V><G><A><F><L><I><Y><I><S><S><D><Y><V><F><D><G><T><N><P><P><Y><R><E><E><D><I><P><A><P><L><N><L><Y><G><K><T><K><L><D><G><E><K><A><V><L><E><N><N><L><G><A><A><V><L><R><I><P><I><L><Y><G><E><V><E><K><L><E><E><S><A><V><T><V><M><F><D><K><V><Q><F><S><N><K><S><A><N><M><D><H><W><Q><Q><R><F><P><T><H><V><K><D><V><A><T><V><C><R><Q><L><A><E><K><R><M><L><D><P><S><I><K><G><T><F><H><W><S><G><N><E><Q><M><T><K><Y><E><M><A><C><A><I><A><D><A><F><N><L><P><S><S><H><L><R><P><I><T><D><S><P><V><L><G><A><Q><R><P><R><N><A><Q><L><D><C><S><K><L><E><T><L><G><I><G><Q><R><T><P><F><R><I><G><I><K><E><S><L><W><P><F><L><I><D><K><R><W><R><Q><T><V><F><H> | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine . Can bind NADP (in vitro) .<BOP> | Q9NZL9 |
P60033 | CD81_HUMAN | Tetraspanin-28 | Homo | <M><G><V><E><G><C><T><K><C><I><K><Y><L><L><F><V><F><N><F><V><F><W><L><A><G><G><V><I><L><G><V><A><L><W><L><R><H><D><P><Q><T><T><N><L><L><Y><L><E><L><G><D><K><P><A><P><N><T><F><Y><V><G><I><Y><I><L><I><A><V><G><A><V><M><M><F><V><G><F><L><G><C><Y><G><A><I><Q><E><S><Q><C><L><L><G><T><F><F><T><C><L><V><I><L><F><A><C><E><V><A><A><G><I><W><G><F><V><N><K><D><Q><I><A><K><D><V><K><Q><F><Y><D><Q><A><L><Q><Q><A><V><V><D><D><D><A><N><N><A><K><A><V><V><K><T><F><H><E><T><L><D><C><C><G><S><S><T><L><T><A><L><T><T><S><V><L><K><N><N><L><C><P><S><G><S><N><I><I><S><N><L><F><K><E><D><C><H><Q><K><I><D><D><L><F><S><G><K><L><Y><L><I><G><I><A><A><I><V><V><A><V><I><M><I><F><E><M><I><L><S><M><V><L><C><C><G><I><R><N><S><S><V><Y> | (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.<BOP> | P60033 |
Q8WZ84 | OR8D1_HUMAN | Olfactory receptor-like protein JCG9 | Homo | <M><T><M><E><N><Y><S><M><A><A><Q><F><V><L><D><G><L><T><Q><Q><A><E><L><Q><L><P><L><F><L><L><F><L><G><I><Y><V><V><T><V><V><G><N><L><G><M><I><L><L><I><A><V><S><P><L><L><H><T><P><M><Y><Y><F><L><S><S><L><S><F><V><D><F><C><Y><S><S><V><I><T><P><K><M><L><V><N><F><L><G><K><K><N><T><I><L><Y><S><E><C><M><V><Q><L><F><F><F><V><V><F><V><V><A><E><G><Y><L><L><T><A><M><A><Y><D><R><Y><V><A><I><C><S><P><L><L><Y><N><A><I><M><S><S><W><V><C><S><L><L><V><L><A><A><F><F><L><G><F><L><S><A><L><T><H><T><S><A><M><M><K><L><S><F><C><K><S><H><I><I><N><H><Y><F><C><D><V><L><P><L><L><N><L><S><C><S><N><T><H><L><N><E><L><L><L><F><I><I><A><G><F><N><T><L><V><P><T><L><A><V><A><V><S><Y><A><F><I><L><Y><S><I><L><H><I><R><S><S><E><G><R><S><K><A><F><G><T><C><S><S><H><L><M><A><V><V><I><F><F><G><S><I><T><F><M><Y><F><K><P><P><S><S><N><S><L><D><Q><E><K><V><S><S><V><F><Y><T><T><V><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><K><A><L><R><K><V><L><V><G><K> | Odorant receptor (Potential). May be involved in taste perception.<BOP> | Q8WZ84 |
O15243 | OBRG_HUMAN | OB-R gene-related protein | Homo | <M><A><G><V><K><A><L><V><A><L><S><F><S><G><A><I><G><L><T><F><L><M><L><G><C><A><L><E><D><Y><G><V><Y><W><P><L><F><V><L><I><F><H><A><I><S><P><I><P><H><F><I><A><K><R><V><T><Y><D><S><D><A><T><S><S><A><C><R><E><L><A><Y><F><F><T><T><G><I><V><V><S><A><F><G><F><P><V><I><L><A><R><V><A><V><I><K><W><G><A><C><G><L><V><L><A><G><N><A><V><I><F><L><T><I><Q><G><F><F><L><I><F><G><R><G><D><D><F><S><W><E><Q><W> | Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.<BOP> | O15243 |
Q8NGL9 | OR4CG_HUMAN | Olfactory receptor OR11-135 | Homo | <M><Q><L><N><N><N><V><T><E><F><I><L><L><G><L><T><Q><D><P><F><W><K><K><I><V><F><V><I><F><L><R><L><Y><L><G><T><L><L><G><N><L><L><I><I><I><S><V><K><T><S><Q><A><L><K><N><P><M><F><F><F><L><F><Y><L><S><L><S><D><T><C><L><S><T><S><I><T><P><R><M><I><V><D><A><L><L><K><K><T><T><I><S><F><S><E><C><M><I><Q><V><F><S><S><H><V><F><G><C><L><E><I><F><I><L><I><L><T><A><V><D><R><Y><V><D><I><C><K><P><L><H><Y><M><T><I><I><S><Q><W><V><C><G><V><L><M><A><V><A><W><V><G><S><C><V><H><S><L><V><Q><I><F><L><A><L><S><L><P><F><C><G><P><N><V><I><N><H><C><F><C><D><L><Q><P><L><L><K><Q><A><C><S><E><T><Y><V><V><N><L><L><L><V><S><N><S><G><A><I><C><A><V><S><Y><V><M><L><I><F><S><Y><V><I><F><L><H><S><L><R><N><H><S><A><E><V><I><K><K><A><L><S><T><C><V><S><H><I><I><V><V><I><L><F><F><G><P><C><I><F><M><Y><T><C><L><A><T><V><F><P><M><D><K><M><I><A><V><F><Y><T><V><G><T><S><F><L><N><P><V><I><Y><T><L><K><N><T><E><V><K><S><A><M><R><K><L><W><S><K><K><L><I><T><D><D><K><R> | Odorant receptor.<BOP> | Q8NGL9 |
O95389 | CCN6_HUMAN | WNT1-inducible-signaling pathway protein 3 | Homo | <M><Q><G><L><L><F><S><T><L><L><L><A><G><L><A><Q><F><C><C><R><V><Q><G><T><G><P><L><D><T><T><P><E><G><R><P><G><E><V><S><D><A><P><Q><R><K><Q><F><C><H><W><P><C><K><C><P><Q><Q><K><P><R><C><P><P><G><V><S><L><V><R><D><G><C><G><C><C><K><I><C><A><K><Q><P><G><E><I><C><N><E><A><D><L><C><D><P><H><K><G><L><Y><C><D><Y><S><V><D><R><P><R><Y><E><T><G><V><C><A><Y><L><V><A><V><G><C><E><F><N><Q><V><H><Y><H><N><G><Q><V><F><Q><P><N><P><L><F><S><C><L><C><V><S><G><A><I><G><C><T><P><L><F><I><P><K><L><A><G><S><H><C><S><G><A><K><G><G><K><K><S><D><Q><S><N><C><S><L><E><P><L><L><Q><Q><L><S><T><S><Y><K><T><M><P><A><Y><R><N><L><P><L><I><W><K><K><K><C><L><V><Q><A><T><K><W><T><P><C><S><R><T><C><G><M><G><I><S><N><R><V><T><N><E><N><S><N><C><E><M><R><K><E><K><R><L><C><Y><I><Q><P><C><D><S><N><I><L><K><T><I><K><I><P><K><G><K><T><C><Q><P><T><F><Q><L><S><K><A><E><K><F><V><F><S><G><C><S><S><T><Q><S><Y><K><P><T><F><C><G><I><C><L><D><K><R><C><C><I><P><N><K><S><K><M><I><T><I><Q><F><D><C><P><N><E><G><S><F><K><W><K><M><L><W><I><T><S><C><V><C><Q><R><N><C><R><E><P><G><D><I><F><S><E><L><K><I><L> | Plays a role in mitochondrial electron transport and mitochondrial respiration . Through its regulation of the mitochondrial function may play a role in normal postnatal skeletal growth and cartilage homeostasis .<BOP> | O95389 |
P04435 | TVB79_HUMAN | T cell receptor beta variable 7-9 | Homo | <M><G><T><S><L><L><C><W><M><A><L><C><L><L><G><A><D><H><A><D><T><G><V><S><Q><N><P><R><H><K><I><T><K><R><G><Q><N><V><T><F><R><C><D><P><I><S><E><H><N><R><L><Y><W><Y><R><Q><T><L><G><Q><G><P><E><F><L><T><Y><F><Q><N><E><A><Q><L><E><K><S><R><L><L><S><D><R><F><S><A><E><R><P><K><G><S><F><S><T><L><E><I><Q><R><T><E><Q><G><D><S><A><M><Y><L><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | P04435 |
O75431 | MTX2_HUMAN | Mitochondrial outer membrane import complex protein 2 | Homo | <M><S><L><V><A><E><A><F><V><S><Q><I><A><A><A><E><P><W><P><E><N><A><T><L><Y><Q><Q><L><K><G><E><Q><I><L><L><S><D><N><A><A><S><L><A><V><Q><A><F><L><Q><M><C><N><L><P><I><K><V><V><C><R><A><N><A><E><Y><M><S><P><S><G><K><V><P><F><I><H><V><G><N><Q><V><V><S><E><L><G><P><I><V><Q><F><V><K><A><K><G><H><S><L><S><D><G><L><E><E><V><Q><K><A><E><M><K><A><Y><M><E><L><V><N><N><M><L><L><T><A><E><L><Y><L><Q><W><C><D><E><A><T><V><G><E><I><T><H><A><R><Y><G><S><P><Y><P><W><P><L><N><H><I><L><A><Y><Q><K><Q><W><E><V><K><R><K><M><K><A><I><G><W><G><K><K><T><L><D><Q><V><L><E><D><V><D><Q><C><C><Q><A><L><S><Q><R><L><G><T><Q><P><Y><F><F><N><K><Q><P><T><E><L><D><A><L><V><F><G><H><L><Y><T><I><L><T><T><Q><L><T><N><D><E><L><S><E><K><V><K><N><Y><S><N><L><L><A><F><C><R><R><I><E><Q><H><Y><F><E><D><R><G><K><G><R><L><S> | Involved in transport of proteins into the mitochondrion.<BOP> | O75431 |
Q96JY6 | PDLI2_HUMAN | PDZ-LIM protein mystique | Homo | <M><A><L><T><V><D><V><A><G><P><A><P><W><G><F><R><I><T><G><G><R><D><F><H><T><P><I><M><V><T><K><V><A><E><R><G><K><A><K><D><A><D><L><R><P><G><D><I><I><V><A><I><N><G><E><S><A><E><G><M><L><H><A><E><A><Q><S><K><I><R><Q><S><P><S><P><L><R><L><Q><L><D><R><S><Q><A><T><S><P><G><Q><T><N><G><D><S><S><L><E><V><L><A><T><R><F><Q><G><S><V><R><T><Y><T><E><S><Q><S><S><L><R><S><S><Y><S><S><P><T><S><L><S><P><R><A><G><S><P><F><S><P><P><P><S><S><S><S><L><T><G><E><A><A><I><S><R><S><F><Q><S><L><A><C><S><P><G><L><P><A><A><D><R><L><S><Y><S><G><R><P><G><S><R><Q><A><G><L><G><R><A><G><D><S><A><V><L><V><L><P><P><S><P><G><P><R><S><S><R><P><S><M><D><S><E><G><G><S><L><L><L><D><E><D><S><E><V><F><K><M><L><Q><E><N><R><E><G><R><A><A><P><R><Q><S><S><S><F><R><L><L><Q><E><A><L><E><A><E><E><R><G><G><T><P><A><F><L><P><S><S><L><S><P><Q><S><S><L><P><A><S><R><A><L><A><T><P><P><K><L><H><T><C><E><K><C><S><T><S><I><A><N><Q><A><V><R><I><Q><E><G><R><Y><R><H><P><G><C><Y><T><C><A><D><C><G><L><N><L><K><M><R><G><H><F><W><V><G><D><E><L><Y><C><E><K><H><A><R><Q><R><Y><S><A><P><A><T><L><S><S><R><A> | Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.<BOP> | Q96JY6 |
P51582 | P2RY4_HUMAN | Uridine nucleotide receptor | Homo | <M><A><S><T><E><S><S><L><L><R><S><L><G><L><S><P><G><P><G><S><S><E><V><E><L><D><C><W><F><D><E><D><F><K><F><I><L><L><P><V><S><Y><A><V><V><F><V><L><G><L><G><L><N><A><P><T><L><W><L><F><I><F><R><L><R><P><W><D><A><T><A><T><Y><M><F><H><L><A><L><S><D><T><L><Y><V><L><S><L><P><T><L><I><Y><Y><Y><A><A><H><N><H><W><P><F><G><T><E><I><C><K><F><V><R><F><L><F><Y><W><N><L><Y><C><S><V><L><F><L><T><C><I><S><V><H><R><Y><L><G><I><C><H><P><L><R><A><L><R><W><G><R><P><R><L><A><G><L><L><C><L><A><V><W><L><V><V><A><G><C><L><V><P><N><L><F><F><V><T><T><S><N><K><G><T><T><V><L><C><H><D><T><T><R><P><E><E><F><D><H><Y><V><H><F><S><S><A><V><M><G><L><L><F><G><V><P><C><L><V><T><L><V><C><Y><G><L><M><A><R><R><L><Y><Q><P><L><P><G><S><A><Q><S><S><S><R><L><R><S><L><R><T><I><A><V><V><L><T><V><F><A><V><C><F><V><P><F><H><I><T><R><T><I><Y><Y><L><A><R><L><L><E><A><D><C><R><V><L><N><I><V><N><V><V><Y><K><V><T><R><P><L><A><S><A><N><S><C><L><D><P><V><L><Y><L><L><T><G><D><K><Y><R><R><Q><L><R><Q><L><C><G><G><G><K><P><Q><P><R><T><A><A><S><S><L><A><L><V><S><L><P><E><D><S><S><C><R><W><A><A><T><P><Q><D><S><S><C><S><T><P><R><A><D><R><L> | Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.<BOP> | P51582 |
P31994 | FCG2B_HUMAN | Fc-gamma RII-b | Homo | <M><G><I><L><S><F><L><P><V><L><A><T><E><S><D><W><A><D><C><K><S><P><Q><P><W><G><H><M><L><L><W><T><A><V><L><F><L><A><P><V><A><G><T><P><A><A><P><P><K><A><V><L><K><L><E><P><Q><W><I><N><V><L><Q><E><D><S><V><T><L><T><C><R><G><T><H><S><P><E><S><D><S><I><Q><W><F><H><N><G><N><L><I><P><T><H><T><Q><P><S><Y><R><F><K><A><N><N><N><D><S><G><E><Y><T><C><Q><T><G><Q><T><S><L><S><D><P><V><H><L><T><V><L><S><E><W><L><V><L><Q><T><P><H><L><E><F><Q><E><G><E><T><I><V><L><R><C><H><S><W><K><D><K><P><L><V><K><V><T><F><F><Q><N><G><K><S><K><K><F><S><R><S><D><P><N><F><S><I><P><Q><A><N><H><S><H><S><G><D><Y><H><C><T><G><N><I><G><Y><T><L><Y><S><S><K><P><V><T><I><T><V><Q><A><P><S><S><S><P><M><G><I><I><V><A><V><V><T><G><I><A><V><A><A><I><V><A><A><V><V><A><L><I><Y><C><R><K><K><R><I><S><A><L><P><G><Y><P><E><C><R><E><M><G><E><T><L><P><E><K><P><A><N><P><T><N><P><D><E><A><D><K><V><G><A><E><N><T><I><T><Y><S><L><L><M><H><P><D><A><L><E><E><P><D><D><Q><N><R><I> | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.<BOP> | P31994 |
Q9H9Q2 | CSN7B_HUMAN | JAB1-containing signalosome subunit 7b | Homo | <M><A><G><E><Q><K><P><S><S><N><L><L><E><Q><F><I><L><L><A><K><G><T><S><G><S><A><L><T><A><L><I><S><Q><V><L><E><A><P><G><V><Y><V><F><G><E><L><L><E><L><A><N><V><Q><E><L><A><E><G><A><N><A><A><Y><L><Q><L><L><N><L><F><A><Y><G><T><Y><P><D><Y><I><A><N><K><E><S><L><P><E><L><S><T><A><Q><Q><N><K><L><K><H><L><T><I><V><S><L><A><S><R><M><K><C><I><P><Y><S><V><L><L><K><D><L><E><M><R><N><L><R><E><L><E><D><L><I><I><E><A><V><Y><T><D><I><I><Q><G><K><L><D><Q><R><N><Q><L><L><E><V><D><F><C><I><G><R><D><I><R><K><K><D><I><N><N><I><V><K><T><L><H><E><W><C><D><G><C><E><A><V><L><L><G><I><E><Q><Q><V><L><R><A><N><Q><Y><K><E><N><H><N><R><T><Q><Q><Q><V><E><A><E><V><T><N><I><K><K><T><L><K><A><T><A><S><S><S><A><Q><E><M><E><Q><Q><L><A><E><R><E><C><P><P><H><A><E><Q><R><Q><P><T><K><K><M><S><K><V><K><G><L><V><S><S><R><H> | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.<BOP> | Q9H9Q2 |
P42701 | I12R1_HUMAN | IL-12 receptor beta component | Homo | <M><E><P><L><V><T><W><V><V><P><L><L><F><L><F><L><L><S><R><Q><G><A><A><C><R><T><S><E><C><C><F><Q><D><P><P><Y><P><D><A><D><S><G><S><A><S><G><P><R><D><L><R><C><Y><R><I><S><S><D><R><Y><E><C><S><W><Q><Y><E><G><P><T><A><G><V><S><H><F><L><R><C><C><L><S><S><G><R><C><C><Y><F><A><A><G><S><A><T><R><L><Q><F><S><D><Q><A><G><V><S><V><L><Y><T><V><T><L><W><V><E><S><W><A><R><N><Q><T><E><K><S><P><E><V><T><L><Q><L><Y><N><S><V><K><Y><E><P><P><L><G><D><I><K><V><S><K><L><A><G><Q><L><R><M><E><W><E><T><P><D><N><Q><V><G><A><E><V><Q><F><R><H><R><T><P><S><S><P><W><K><L><G><D><C><G><P><Q><D><D><D><T><E><S><C><L><C><P><L><E><M><N><V><A><Q><E><F><Q><L><R><R><R><Q><L><G><S><Q><G><S><S><W><S><K><W><S><S><P><V><C><V><P><P><E><N><P><P><Q><P><Q><V><R><F><S><V><E><Q><L><G><Q><D><G><R><R><R><L><T><L><K><E><Q><P><T><Q><L><E><L><P><E><G><C><Q><G><L><A><P><G><T><E><V><T><Y><R><L><Q><L><H><M><L><S><C><P><C><K><A><K><A><T><R><T><L><H><L><G><K><M><P><Y><L><S><G><A><A><Y><N><V><A><V><I><S><S><N><Q><F><G><P><G><L><N><Q><T><W><H><I><P><A><D><T><H><T><E><P><V><A><L><N><I><S><V><G><T><N><G><T><T><M><Y><W><P><A><R><A><Q><S><M><T><Y><C><I><E><W><Q><P><V><G><Q><D><G><G><L><A><T><C><S><L><T><A><P><Q><D><P><D><P><A><G><M><A><T><Y><S><W><S><R><E><S><G><A><M><G><Q><E><K><C><Y><Y><I><T><I><F><A><S><A><H><P><E><K><L><T><L><W><S><T><V><L><S><T><Y><H><F><G><G><N><A><S><A><A><G><T><P><H><H><V><S><V><K><N><H><S><L><D><S><V><S><V><D><W><A><P><S><L><L><S><T><C><P><G><V><L><K><E><Y><V><V><R><C><R><D><E><D><S><K><Q><V><S><E><H><P><V><Q><P><T><E><T><Q><V><T><L><S><G><L><R><A><G><V><A><Y><T><V><Q><V><R><A><D><T><A><W><L><R><G><V><W><S><Q><P><Q><R><F><S><I><E><V><Q><V><S><D><W><L><I><F><F><A><S><L><G><S><F><L><S><I><L><L><V><G><V><L><G><Y><L><G><L><N><R><A><A><R><H><L><C><P><P><L><P><T><P><C><A><S><S><A><I><E><F><P><G><G><K><E><T><W><Q><W><I><N><P><V><D><F><Q><E><E><A><S><L><Q><E><A><L><V><V><E><M><S><W><D><K><G><E><R><T><E><P><L><E><K><T><E><L><P><E><G><A><P><E><L><A><L><D><T><E><L><S><L><E><D><G><D><R><C><K><A><K><M> | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.<BOP> | P42701 |
Q8NB42 | ZN527_HUMAN | Zinc finger protein 527 | Homo | <M><A><V><G><L><C><K><A><M><S><Q><G><L><V><T><F><R><D><V><A><L><D><F><S><Q><E><E><W><E><W><L><K><P><S><Q><K><D><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><W><L><G><L><S><I><S><K><P><N><M><I><S><L><L><E><Q><G><K><E><P><W><M><V><E><R><K><M><S><Q><G><H><C><A><D><W><E><S><W><C><E><I><E><E><L><S><P><K><W><F><I><D><E><D><E><I><S><Q><E><M><V><M><E><R><L><A><S><H><G><L><E><C><S><S><F><R><E><A><W><K><Y><K><G><E><F><E><L><H><Q><G><N><A><E><R><H><F><M><Q><V><T><A><V><K><E><I><S><T><G><K><R><D><N><E><F><S><N><S><G><R><S><I><P><L><K><S><V><F><L><T><Q><Q><K><V><P><T><I><Q><Q><V><H><K><F><D><I><Y><D><K><L><F><P><Q><N><S><V><I><I><E><Y><K><R><L><H><A><E><K><E><S><L><I><G><N><E><C><E><E><F><N><Q><S><T><Y><L><S><K><D><I><G><I><P><P><G><E><K><P><Y><E><S><H><D><F><S><K><L><L><S><F><H><S><L><F><T><Q><H><Q><T><T><H><F><G><K><L><P><H><G><Y><D><E><C><G><D><A><F><S><C><Y><S><F><F><T><Q><P><Q><R><I><H><S><G><E><K><P><Y><A><C><N><D><C><G><K><A><F><S><H><D><F><F><L><S><E><H><Q><R><T><H><I><G><E><K><P><Y><E><C><K><E><C><N><K><A><F><R><Q><S><A><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><F><A><C><N><E><C><G><K><A><F><S><R><Y><A><F><L><V><E><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><N><K><A><F><R><Q><S><A><H><L><N><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><Q><C><G><K><A><F><S><R><R><I><A><L><T><L><H><Q><R><I><H><T><G><E><K><P><F><K><C><S><E><C><G><K><T><F><G><Y><R><S><H><L><N><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><I><K><C><G><K><F><F><R><T><D><S><Q><L><N><R><H><H><R><I><H><T><G><E><R><P><F><E><C><S><K><C><G><K><A><F><S><D><A><L><V><L><I><H><H><K><R><S><H><A><G><E><K><P><Y><E><C><N><K><C><G><K><A><F><S><C><G><S><Y><L><N><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><H><Q><I><L><S><L><R><L><H><Q><R><I><H><A><G><E><K><P><Y><K><C><N><E><C><G><N><N><F><S><C><V><S><A><L><R><R><H><Q><R><I><H><N><R><E><T><L> | May be involved in transcriptional regulation.<BOP> | Q8NB42 |
P04843 | RPN1_HUMAN | Ribophorin-1 | Homo | <M><E><A><P><A><A><G><L><F><L><L><L><L><L><G><T><W><A><P><A><P><G><S><A><S><S><E><A><P><P><L><I><N><E><D><V><K><R><T><V><D><L><S><S><H><L><A><K><V><T><A><E><V><V><L><A><H><L><G><G><G><S><T><S><R><A><T><S><F><L><L><A><L><E><P><E><L><E><A><R><L><A><H><L><G><V><Q><V><K><G><E><D><E><E><E><N><N><L><E><V><R><E><T><K><I><K><G><K><S><G><R><F><F><T><V><K><L><P><V><A><L><D><P><G><A><K><I><S><V><I><V><E><T><V><Y><T><H><V><L><H><P><Y><P><T><Q><I><T><Q><S><E><K><Q><F><V><V><F><E><G><N><H><Y><F><Y><S><P><Y><P><T><K><T><Q><T><M><R><V><K><L><A><S><R><N><V><E><S><Y><T><K><L><G><N><P><T><R><S><E><D><L><L><D><Y><G><P><F><R><D><V><P><A><Y><S><Q><D><T><F><K><V><H><Y><E><N><N><S><P><F><L><T><I><T><S><M><T><R><V><I><E><V><S><H><W><G><N><I><A><V><E><E><N><V><D><L><K><H><T><G><A><V><L><K><G><P><F><S><R><Y><D><Y><Q><R><Q><P><D><S><G><I><S><S><I><R><S><F><K><T><I><L><P><A><A><A><Q><D><V><Y><Y><R><D><E><I><G><N><V><S><T><S><H><L><L><I><L><D><D><S><V><E><M><E><I><R><P><R><F><P><L><F><G><G><W><K><T><H><Y><I><V><G><Y><N><L><P><S><Y><E><Y><L><Y><N><L><G><D><Q><Y><A><L><K><M><R><F><V><D><H><V><F><D><E><Q><V><I><D><S><L><T><V><K><I><I><L><P><E><G><A><K><N><I><E><I><D><S><P><Y><E><I><S><R><A><P><D><E><L><H><Y><T><Y><L><D><T><F><G><R><P><V><I><V><A><Y><K><K><N><L><V><E><Q><H><I><Q><D><I><V><V><H><Y><T><F><N><K><V><L><M><L><Q><E><P><L><L><V><V><A><A><F><Y><I><L><F><F><T><V><I><I><Y><V><R><L><D><F><S><I><T><K><D><P><A><A><E><A><R><M><K><V><A><C><I><T><E><Q><V><L><T><L><V><N><K><R><I><G><L><Y><R><H><F><D><E><T><V><N><R><Y><K><Q><S><R><D><I><S><T><L><N><S><G><K><K><S><L><E><T><E><H><K><A><L><T><S><E><I><A><L><L><Q><S><R><L><K><T><E><G><S><D><L><C><D><R><V><S><E><M><Q><K><L><D><A><Q><V><K><E><L><V><L><K><S><A><V><E><A><E><R><L><V><A><G><K><L><K><K><D><T><Y><I><E><N><E><K><L><I><S><G><K><R><Q><E><L><V><T><K><I><D><H><I><L><D><A><L> | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.<BOP> | P04843 |
P57773 | CXA9_HUMAN | Gap junction alpha-10 protein | Homo | <M><G><D><W><N><L><L><G><D><T><L><E><E><V><H><I><H><S><T><M><I><G><K><I><W><L><T><I><L><F><I><F><R><M><L><V><L><G><V><A><A><E><D><V><W><N><D><E><Q><S><G><F><I><C><N><T><E><Q><P><G><C><R><N><V><C><Y><D><Q><A><F><P><I><S><L><I><R><Y><W><V><L><Q><V><I><F><V><S><S><P><S><L><V><Y><M><G><H><A><L><Y><R><L><R><V><L><E><E><E><R><Q><R><M><K><A><Q><L><R><V><E><L><E><E><V><E><F><E><M><P><R><D><R><R><R><L><E><Q><E><L><C><Q><L><E><K><R><K><L><N><K><A><P><L><R><G><T><L><L><C><T><Y><V><I><H><I><F><T><R><S><V><V><E><V><G><F><M><I><G><Q><Y><L><L><Y><G><F><H><L><E><P><L><F><K><C><H><G><H><P><C><P><N><I><I><D><C><F><V><S><R><P><T><E><K><T><I><F><L><L><F><M><Q><S><I><A><T><I><S><L><F><L><N><I><L><E><I><F><H><L><G><F><K><K><I><K><R><G><L><W><G><K><Y><K><L><K><K><E><H><N><E><F><H><A><N><K><A><K><Q><N><V><A><K><Y><Q><S><T><S><A><N><S><L><K><R><L><P><S><A><P><D><Y><N><L><L><V><E><K><Q><T><H><T><A><V><Y><P><S><L><N><S><S><S><V><F><Q><P><N><P><D><N><H><S><V><N><D><E><K><C><I><L><D><E><Q><E><T><V><L><S><N><E><I><S><T><L><S><T><S><C><S><H><F><Q><H><I><S><S><N><N><N><K><D><T><H><K><I><F><G><K><E><L><N><G><N><Q><L><M><E><K><R><E><T><E><G><K><D><S><K><R><N><Y><Y><S><R><G><H><R><S><I><P><G><V><A><I><D><G><E><N><N><M><R><Q><S><P><Q><T><V><F><S><L><P><A><N><C><D><W><K><P><R><W><L><R><A><T><W><G><S><S><T><E><H><E><N><R><G><S><P><P><K><G><N><L><K><G><Q><F><R><K><G><T><V><R><T><L><P><P><S><Q><G><D><S><Q><S><L><D><I><P><N><T><A><D><S><L><G><G><L><S><F><E><P><G><L><V><R><T><C><N><N><P><V><C><P><P><N><H><V><V><S><L><T><N><N><L><I><G><R><R><V><P><T><D><L><Q><I> | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.<BOP> | P57773 |
A2RUC4 | TYW5_HUMAN | tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase | Homo | <M><A><G><Q><H><L><P><V><P><R><L><E><G><V><S><R><E><Q><F><M><Q><H><L><Y><P><Q><R><K><P><L><V><L><E><G><I><D><L><G><P><C><T><S><K><W><T><V><D><Y><L><S><Q><V><G><G><K><K><E><V><K><I><H><V><A><A><V><A><Q><M><D><F><I><S><K><N><F><V><Y><R><T><L><P><F><D><Q><L><V><Q><R><A><A><E><E><K><H><K><E><F><F><V><S><E><D><E><K><Y><Y><L><R><S><L><G><E><D><P><R><K><D><V><A><D><I><R><K><Q><F><P><L><L><K><G><D><I><K><F><P><E><F><F><K><E><E><Q><F><F><S><S><V><F><R><I><S><S><P><G><L><Q><L><W><T><H><Y><D><V><M><D><N><L><L><I><Q><V><T><G><K><K><R><V><V><L><F><S><P><R><D><A><Q><Y><L><Y><L><K><G><T><K><S><E><V><L><N><I><D><N><P><D><L><A><K><Y><P><L><F><S><K><A><R><R><Y><E><C><S><L><E><A><G><D><V><L><F><I><P><A><L><W><F><H><N><V><I><S><E><E><F><G><V><G><V><N><I><F><W><K><H><L><P><S><E><C><Y><D><K><T><D><T><Y><G><N><K><D><P><T><A><A><S><R><A><A><Q><I><L><D><R><A><L><K><T><L><A><E><L><P><E><E><Y><R><D><F><Y><A><R><R><M><V><L><H><I><Q><D><K><A><Y><S><K><N><S><E> | tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.<BOP> | A2RUC4 |
Q9H8P0 | PORED_HUMAN | Steroid 5-alpha-reductase 3 | Homo | <M><A><P><W><A><E><A><E><H><S><A><L><N><P><L><R><A><V><W><L><T><L><T><A><A><F><L><L><T><L><L><L><Q><L><L><P><P><G><L><L><P><G><C><A><I><F><Q><D><L><I><R><Y><G><K><T><K><C><G><E><P><S><R><P><A><A><C><R><A><F><D><V><P><K><R><Y><F><S><H><F><Y><I><I><S><V><L><W><N><G><F><L><L><W><C><L><T><Q><S><L><F><L><G><A><P><F><P><S><W><L><H><G><L><L><R><I><L><G><A><A><Q><F><Q><G><G><E><L><A><L><S><A><F><L><V><L><V><F><L><W><L><H><S><L><R><R><L><F><E><C><L><Y><V><S><V><F><S><N><V><M><I><H><V><V><Q><Y><C><F><G><L><V><Y><Y><V><L><V><G><L><T><V><L><S><Q><V><P><M><D><G><R><N><A><Y><I><T><G><K><N><L><L><M><Q><A><R><W><F><H><I><L><G><M><M><M><F><I><W><S><S><A><H><Q><Y><K><C><H><V><I><L><G><N><L><R><K><N><K><A><G><V><V><I><H><C><N><H><R><I><P><F><G><D><W><F><E><Y><V><S><S><P><N><Y><L><A><E><L><M><I><Y><V><S><M><A><V><T><F><G><F><H><N><L><T><W><W><L><V><V><T><N><V><F><F><N><Q><A><L><S><A><F><L><S><H><Q><F><Y><K><S><K><F><V><S><Y><P><K><H><R><K><A><F><L><P><F><L><F> | Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol . Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation . Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism . Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) .<BOP> | Q9H8P0 |
P34949 | MPI_HUMAN | Phosphomannose isomerase | Homo | <M><A><A><P><R><V><F><P><L><S><C><A><V><Q><Q><Y><A><W><G><K><M><G><S><N><S><E><V><A><R><L><L><A><S><S><D><P><L><A><Q><I><A><E><D><K><P><Y><A><E><L><W><M><G><T><H><P><R><G><D><A><K><I><L><D><N><R><I><S><Q><K><T><L><S><Q><W><I><A><E><N><Q><D><S><L><G><S><K><V><K><D><T><F><N><G><N><L><P><F><L><F><K><V><L><S><V><E><T><P><L><S><I><Q><A><H><P><N><K><E><L><A><E><K><L><H><L><Q><A><P><Q><H><Y><P><D><A><N><H><K><P><E><M><A><I><A><L><T><P><F><Q><G><L><C><G><F><R><P><V><E><E><I><V><T><F><L><K><K><V><P><E><F><Q><F><L><I><G><D><E><A><A><T><H><L><K><Q><T><M><S><H><D><S><Q><A><V><A><S><S><L><Q><S><C><F><S><H><L><M><K><S><E><K><K><V><V><V><E><Q><L><N><L><L><V><K><R><I><S><Q><Q><A><A><A><G><N><N><M><E><D><I><F><G><E><L><L><L><Q><L><H><Q><Q><Y><P><G><D><I><G><C><F><A><I><Y><F><L><N><L><L><T><L><K><P><G><E><A><M><F><L><E><A><N><V><P><H><A><Y><L><K><G><D><C><V><E><C><M><A><C><S><D><N><T><V><R><A><G><L><T><P><K><F><I><D><V><P><T><L><C><E><M><L><S><Y><T><P><S><S><S><K><D><R><L><F><L><P><T><R><S><Q><E><D><P><Y><L><S><I><Y><D><P><P><V><P><D><F><T><I><M><K><T><E><V><P><G><S><V><T><E><Y><K><V><L><A><L><D><S><A><S><I><L><L><M><V><Q><G><T><V><I><A><S><T><P><T><T><Q><T><P><I><P><L><Q><R><G><G><V><L><F><I><G><A><N><E><S><V><S><L><K><L><T><E><P><K><D><L><L><I><F><R><A><C><C><L><L> | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.<BOP> | P34949 |
Q15937 | ZNF79_HUMAN | ZNFpT7 | Homo | <M><L><E><E><G><V><L><P><S><P><G><P><A><L><P><Q><E><E><N><T><G><E><E><G><M><A><A><G><L><L><T><A><G><P><R><G><S><T><F><F><S><S><V><T><V><A><F><A><Q><E><R><W><R><C><L><V><S><T><P><R><D><R><F><K><E><G><I><P><G><K><S><R><S><L><V><L><L><G><L><P><V><S><Q><P><G><M><N><S><Q><L><E><Q><R><E><G><A><W><M><L><E><G><E><D><L><R><S><P><S><P><G><W><K><I><I><S><G><S><P><P><E><Q><A><L><S><E><A><S><F><Q><D><P><C><V><E><M><P><P><G><D><S><D><H><G><T><S><D><L><E><K><S><F><N><L><R><P><V><L><S><P><Q><Q><R><V><P><V><E><A><R><P><R><K><C><E><T><H><T><E><S><F><K><N><S><E><I><L><K><P><H><R><A><K><P><Y><A><C><N><E><C><G><K><A><F><S><Y><C><S><S><L><S><Q><H><Q><K><S><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><S><Q><S><S><S><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><S><E><C><G><R><A><F><S><Q><N><A><N><L><T><K><H><Q><R><T><H><T><G><E><K><P><Y><R><C><S><E><C><E><K><A><F><S><D><C><S><A><L><V><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><S><D><C><G><K><A><F><R><H><S><A><N><L><T><N><H><Q><R><T><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><S><Y><C><A><A><F><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><R><C><A><A><C><G><K><A><F><S><Q><S><A><N><L><T><N><H><Q><R><T><H><T><G><E><K><P><Y><K><C><S><E><C><G><K><A><F><S><Q><S><T><N><L><I><I><H><Q><K><T><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><F><F><S><E><S><S><A><L><I><R><H><H><I><I><H><T><G><E><K><P><Y><E><C><N><E><C><G><K><A><F><N><Q><S><S><S><L><S><Q><H><Q><R><I><H><T><G><V><K><P><Y><E><C><S><E><C><G><K><A><F><R><C><S><S><A><F><V><R><H><Q><R><L><H><A><G><E> | May be involved in transcriptional regulation.<BOP> | Q15937 |
O15484 | CAN5_HUMAN | New calpain 3 | Homo | <M><F><S><C><V><K><P><Y><E><D><Q><N><Y><S><A><L><R><R><D><C><R><R><R><K><V><L><F><E><D><P><L><F><P><A><T><D><D><S><L><Y><Y><K><G><T><P><G><P><A><V><R><W><K><R><P><K><G><I><C><E><D><P><R><L><F><V><D><G><I><S><S><H><D><L><H><Q><G><Q><V><G><N><C><W><F><V><A><A><C><S><S><L><A><S><R><E><S><L><W><Q><K><V><I><P><D><W><K><E><Q><E><W><D><P><E><K><P><N><A><Y><A><G><I><F><H><F><H><F><W><R><F><G><E><W><V><D><V><V><I><D><D><R><L><P><T><V><N><N><Q><L><I><Y><C><H><S><N><S><R><N><E><F><W><C><A><L><V><E><K><A><Y><A><K><L><A><G><C><Y><Q><A><L><D><G><G><N><T><A><D><A><L><V><D><F><T><G><G><V><S><E><P><I><D><L><T><E><G><D><F><A><N><D><E><T><K><R><N><Q><L><F><E><R><M><L><K><V><H><S><R><G><G><L><I><S><A><S><I><K><A><V><T><A><A><D><M><E><A><R><L><A><C><G><L><V><K><G><H><A><Y><A><V><T><D><V><R><K><V><R><L><G><H><G><L><L><A><F><F><K><S><E><K><L><D><M><I><R><L><R><N><P><W><G><E><R><E><W><N><G><P><W><S><D><T><S><E><E><W><Q><K><V><S><K><S><E><R><E><K><M><G><V><T><V><Q><D><D><G><E><F><W><M><T><F><E><D><V><C><R><Y><F><T><D><I><I><K><C><R><V><I><N><T><S><H><L><S><I><H><K><T><W><E><E><A><R><L><H><G><A><W><T><L><H><E><D><P><R><Q><N><R><G><G><G><C><I><N><H><K><D><T><F><F><Q><N><P><Q><Y><I><F><E><V><K><K><P><E><D><E><V><L><I><C><I><Q><Q><R><P><K><R><S><T><R><R><E><G><K><G><E><N><L><A><I><G><F><D><I><Y><K><V><E><E><N><R><Q><Y><R><M><H><S><L><Q><H><K><A><A><S><S><I><Y><I><N><S><R><S><V><F><L><R><T><D><Q><P><E><G><R><Y><V><I><I><P><T><T><F><E><P><G><H><T><G><E><F><L><L><R><V><F><T><D><V><P><S><N><C><R><E><L><R><L><D><E><P><P><H><T><C><W><S><S><L><C><G><Y><P><Q><L><V><T><Q><V><H><V><L><G><A><A><G><L><K><D><S><P><T><G><A><N><S><Y><V><I><I><K><C><E><G><D><K><V><R><S><A><V><Q><K><G><T><S><T><P><E><Y><N><V><K><G><I><F><Y><R><K><K><L><S><Q><P><I><T><V><Q><V><W><N><H><R><V><L><K><D><E><F><L><G><Q><V><H><L><K><A><D><P><D><N><L><Q><A><L><H><T><L><H><L><R><D><R><N><S><R><Q><P><S><N><L><P><G><T><V><A><V><H><I><L><S><S><T><S><L><M><A><V> | Calcium-regulated non-lysosomal thiol-protease.<BOP> | O15484 |
Q15013 | MD2BP_HUMAN | p31(comet) | Homo | <M><A><A><P><E><A><E><V><L><S><S><A><A><V><P><D><L><E><W><Y><E><K><S><E><E><T><H><A><S><Q><I><E><L><L><E><T><S><S><T><Q><E><P><L><N><A><S><E><A><F><C><P><R><D><C><M><V><P><V><V><F><P><G><P><V><S><Q><E><G><C><C><Q><F><T><C><E><L><L><K><H><I><M><Y><Q><R><Q><Q><L><P><L><P><Y><E><Q><L><K><H><F><Y><R><K><P><S><P><Q><A><E><E><M><L><K><K><K><P><R><A><T><T><E><V><S><S><R><K><C><Q><Q><A><L><A><E><L><E><S><V><L><S><H><L><E><D><F><F><A><R><T><L><V><P><R><V><L><I><L><L><G><G><N><A><L><S><P><K><E><F><Y><E><L><D><L><S><L><L><A><P><Y><S><V><D><Q><S><L><S><T><A><A><C><L><R><R><L><F><R><A><I><F><M><A><D><A><F><S><E><L><Q><A><P><P><L><M><G><T><V><V><M><A><Q><G><H><R><N><C><G><E><D><W><F><R><P><K><L><N><Y><R><V><P><S><R><G><H><K><L><T><V><T><L><S><C><G><R><P><S><I><R><T><T><A><W><E><D><Y><I><W><F><Q><A><P><V><T><F><K><G><F><R><E> | May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.<BOP> | Q15013 |
P18440 | ARY1_HUMAN | N-acetyltransferase type 1 | Homo | <M><D><I><E><A><Y><L><E><R><I><G><Y><K><K><S><R><N><K><L><D><L><E><T><L><T><D><I><L><Q><H><Q><I><R><A><V><P><F><E><N><L><N><I><H><C><G><D><A><M><D><L><G><L><E><A><I><F><D><Q><V><V><R><R><N><R><G><G><W><C><L><Q><V><N><H><L><L><Y><W><A><L><T><T><I><G><F><E><T><T><M><L><G><G><Y><V><Y><S><T><P><A><K><K><Y><S><T><G><M><I><H><L><L><L><Q><V><T><I><D><G><R><N><Y><I><V><D><A><G><F><G><R><S><Y><Q><M><W><Q><P><L><E><L><I><S><G><K><D><Q><P><Q><V><P><C><V><F><R><L><T><E><E><N><G><F><W><Y><L><D><Q><I><R><R><E><Q><Y><I><P><N><E><E><F><L><H><S><D><L><L><E><D><S><K><Y><R><K><I><Y><S><F><T><L><K><P><R><T><I><E><D><F><E><S><M><N><T><Y><L><Q><T><S><P><S><S><V><F><T><S><K><S><F><C><S><L><Q><T><P><D><G><V><H><C><L><V><G><F><T><L><T><H><R><R><F><N><Y><K><D><N><T><D><L><I><E><F><K><T><L><S><E><E><E><I><E><K><V><L><K><N><I><F><N><I><S><L><Q><R><K><L><V><P><K><H><G><D><R><F><F><T><I> | Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.<BOP> | P18440 |
Q86YI8 | PHF13_HUMAN | Survival time-associated PHD finger protein in ovarian cancer 1 | Homo | <M><D><S><D><S><C><A><A><A><F><H><P><E><E><Y><S><P><S><C><K><R><R><R><T><V><E><D><F><N><K><F><C><T><F><V><L><A><Y><A><G><Y><I><P><Y><P><K><E><E><L><P><L><R><S><S><P><S><P><A><N><S><T><A><G><T><I><D><S><D><G><W><D><A><G><F><S><D><I><A><S><S><V><P><L><P><V><S><D><R><C><F><S><H><L><Q><P><T><L><L><Q><R><A><K><P><S><N><F><L><L><D><R><K><K><T><D><K><L><K><K><K><K><K><R><K><R><R><D><S><D><A><P><G><K><E><G><Y><R><G><G><L><L><K><L><E><A><A><D><P><Y><V><E><T><P><T><S><P><T><L><Q><D><I><P><Q><A><P><S><D><P><C><S><G><W><D><S><D><T><P><S><S><G><S><C><A><T><V><S><P><D><Q><V><K><E><I><K><T><E><G><K><R><T><I><V><R><Q><G><K><Q><V><V><F><R><D><E><D><S><T><G><N><D><E><D><I><M><V><D><S><D><D><D><S><W><D><L><V><T><C><F><C><M><K><P><F><A><G><R><P><M><I><E><C><N><E><C><H><T><W><I><H><L><S><C><A><K><I><R><K><S><N><V><P><E><V><F><V><C><Q><K><C><R><D><S><K><F><D><I><R><R><S><N><R><S><R><T><G><S><R><K><L><F><L><D> | Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.<BOP> | Q86YI8 |
Q9Y3T9 | NOC2L_HUMAN | Novel INHAT repressor | Homo | <M><A><A><A><G><S><R><K><R><R><L><A><E><L><T><V><D><E><F><L><A><S><G><F><D><S><E><S><E><S><E><S><E><N><S><P><Q><A><E><T><R><E><A><R><E><A><A><R><S><P><D><K><P><G><G><S><P><S><A><S><R><R><K><G><R><A><S><E><H><K><D><Q><L><S><R><L><K><D><R><D><P><E><F><Y><K><F><L><Q><E><N><D><Q><S><L><L><N><F><S><D><S><D><S><S><E><E><E><E><G><P><F><H><S><L><P><D><V><L><E><E><A><S><E><E><E><D><G><A><E><E><G><E><D><G><D><R><V><P><R><G><L><K><G><K><K><N><S><V><P><V><T><V><A><M><V><E><R><W><K><Q><A><A><K><Q><R><L><T><P><K><L><F><H><E><V><V><Q><A><F><R><A><A><V><A><T><T><R><G><D><Q><E><S><A><E><A><N><K><F><Q><V><T><D><S><A><A><F><N><A><L><V><T><F><C><I><R><D><L><I><G><C><L><Q><K><L><L><F><G><K><V><A><K><D><S><S><R><M><L><Q><P><S><S><S><P><L><W><G><K><L><R><V><D><I><K><A><Y><L><G><S><A><I><Q><L><V><S><C><L><S><E><T><T><V><L><A><A><V><L><R><H><I><S><V><L><V><P><C><F><L><T><F><P><K><Q><C><R><M><L><L><K><R><M><V><I><V><W><S><T><G><E><E><S><L><R><V><L><A><F><L><V><L><S><R><V><C><R><H><K><K><D><T><F><L><G><P><V><L><K><Q><M><Y><I><T><Y><V><R><N><C><K><F><T><S><P><G><A><L><P><F><I><S><F><M><Q><W><T><L><T><E><L><L><A><L><E><P><G><V><A><Y><Q><H><A><F><L><Y><I><R><Q><L><A><I><H><L><R><N><A><M><T><T><R><K><K><E><T><Y><Q><S><V><Y><N><W><Q><Y><V><H><C><L><F><L><W><C><R><V><L><S><T><A><G><P><S><E><A><L><Q><P><L><V><Y><P><L><A><Q><V><I><I><G><C><I><K><L><I><P><T><A><R><F><Y><P><L><R><M><H><C><I><R><A><L><T><L><L><S><G><S><S><G><A><F><I><P><V><L><P><F><I><L><E><M><F><Q><Q><V><D><F><N><R><K><P><G><R><M><S><S><K><P><I><N><F><S><V><I><L><K><L><S><N><V><N><L><Q><E><K><A><Y><R><D><G><L><V><E><Q><L><Y><D><L><T><L><E><Y><L><H><S><Q><A><H><C><I><G><F><P><E><L><V><L><P><V><V><L><Q><L><K><S><F><L><R><E><C><K><V><A><N><Y><C><R><Q><V><Q><Q><L><L><G><K><V><Q><E><N><S><A><Y><I><C><S><R><R><Q><R><V><S><F><G><V><S><E><Q><Q><A><V><E><A><W><E><K><L><T><R><E><E><G><T><P><L><T><L><Y><Y><S><H><W><R><K><L><R><D><R><E><I><Q><L><E><I><S><G><K><E><R><L><E><D><L><N><F><P><E><I><K><R><R><K><M><A><D><R><K><D><E><D><R><K><Q><F><K><D><L><F><D><L><N><S><S><E><E><D><D><T><E><G><F><S><E><R><G><I><L><R><P><L><S><T><R><H><G><V><E><D><D><E><E><D><E><E><E><G><E><E><D><S><S><N><S><E><D><G><D><P><D><A><E><A><G><L><A><P><G><E><L><Q><Q><L><A><Q><G><P><E><D><E><L><E><D><L><Q><L><S><E><D><D> | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.<BOP> | Q9Y3T9 |
Q96M20 | CNBD2_HUMAN | Cyclic nucleotide-binding domain-containing protein 2 | Homo | <M><R><R><H><M><V><T><Y><A><W><Q><L><L><K><K><E><L><G><L><Y><Q><L><A><M><D><I><I><I><M><I><R><V><C><K><M><F><R><Q><G><L><R><G><F><R><E><Y><Q><I><I><E><T><A><H><W><K><H><P><I><F><S><F><W><D><K><K><M><Q><S><R><V><T><F><D><T><M><D><F><I><A><E><E><G><H><F><P><P><K><A><I><Q><I><M><Q><K><K><P><S><W><R><T><E><D><E><I><Q><A><V><C><N><I><L><Q><V><L><D><S><Y><R><N><Y><A><E><P><L><Q><L><L><L><A><K><V><M><R><F><E><R><F><G><R><R><R><V><I><I><K><K><G><Q><K><G><N><S><F><Y><F><I><Y><L><G><T><V><A><I><T><K><D><E><D><G><S><S><A><F><L><D><P><H><P><K><L><L><H><K><G><S><C><F><G><E><M><D><V><L><H><A><S><V><R><R><S><T><I><V><C><M><E><E><T><E><F><L><V><V><D><R><E><D><F><F><A><N><K><L><D><Q><E><V><Q><K><D><A><Q><Y><R><F><E><F><F><R><K><M><E><L><F><A><S><W><S><D><E><K><L><W><Q><L><V><A><M><A><K><I><E><R><F><S><Y><G><Q><L><I><S><K><D><F><G><E><S><P><F><I><M><F><I><S><K><G><S><C><E><V><L><R><L><L><D><L><G><A><S><P><S><Y><R><R><W><I><W><Q><H><L><E><L><I><D><G><R><P><L><K><T><H><L><S><E><Y><S><P><M><E><R><F><K><E><F><Q><I><K><S><Y><P><L><Q><D><F><S><S><L><K><L><P><H><L><K><K><A><W><G><L><Q><G><T><S><F><S><R><K><I><R><T><S><G><D><T><L><P><K><M><L><G><P><K><I><Q><S><R><P><A><Q><S><I><K><C><A><M><I><N><I><K><P><G><E><L><P><K><E><A><A><V><G><A><Y><V><K><V><H><T><V><E><Q><G><E><I><L><G><L><H><Q><A><F><L><P><E><G><E><C><D><T><R><P><L><I><L><M><S><L><G><N><E><L><I><R><I><R><K><E><I><F><Y><E><L><I><D><N><D><D><E><M><I><K><K><L><L><K><L><N><I><A><F><P><S><D><E><D><M><C><Q><K><F><L><Q><Q><N><S><W><N><I><F><R><K><D><L><L><Q><L><L><V><E><P><C><Q><S><Q><L><F><T><P><N><R><P><K><K><R><E><I><Y><N><P><K><S><V><V><L><D><L><C><S><I><N><K><T><T><K><P><R><Y><P><I><F><M><A><P><Q><K><Y><L><P><P><L><R><I><V><Q><A><I><K><A><P><R><Y><K><I><R><E><L><L><A> | Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm.<BOP> | Q96M20 |
P35244 | RFA3_HUMAN | Replication factor A protein 3 | Homo | <M><V><D><M><M><D><L><P><R><S><R><I><N><A><G><M><L><A><Q><F><I><D><K><P><V><C><F><V><G><R><L><E><K><I><H><P><T><G><K><M><F><I><L><S><D><G><E><G><K><N><G><T><I><E><L><M><E><P><L><D><E><E><I><S><G><I><V><E><V><V><G><R><V><T><A><K><A><T><I><L><C><T><S><Y><V><Q><F><K><E><D><S><H><P><F><D><L><G><L><Y><N><E><A><V><K><I><I><H><D><F><P><Q><F><Y><P><L><G><I><V><Q><H><D> | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage . In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response . It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair . Also plays a role in base excision repair (BER), probably through interaction with UNG . Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible | P35244 |
Q9P0P8 | MRES1_HUMAN | Mitochondrial transcription rescue factor 1 | Homo | <M><A><M><A><S><V><K><L><L><A><G><V><L><R><K><P><D><A><W><I><G><L><W><G><V><L><R><G><T><P><S><S><Y><K><L><C><T><S><W><N><R><Y><L><Y><F><S><S><T><K><L><R><A><P><N><Y><K><T><L><F><Y><N><I><F><S><L><R><L><P><G><L><L><L><S><P><E><C><I><F><P><F><S><V><R><L><K><S><N><I><R><S><T><K><S><T><K><K><S><L><Q><K><V><D><E><E><D><S><D><E><E><S><H><H><D><E><M><S><E><Q><E><E><E><L><E><D><D><P><T><V><V><K><N><Y><K><D><L><E><K><A><V><Q><S><F><R><Y><D><V><V><L><K><T><G><L><D><I><G><R><N><K><V><E><D><A><F><Y><K><G><E><L><R><L><N><E><E><K><L><W><K><K><S><R><T><V><K><V><G><D><T><L><D><L><L><I><G><E><D><K><E><A><G><T><E><T><V><M><R><I><L><L><K><K><V><F><E><E><K><T><E><S><E><K><Y><R><V><V><L><R><R><W><K><S><L><K><L><P><K><K><R><M><S><K> | Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability . Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation . As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue .<BOP> | Q9P0P8 |
Q9H5Z1 | DHX35_HUMAN | DEAH box protein 35 | Homo | <M><A><A><P><V><G><P><V><K><F><W><R><P><G><T><E><G><P><G><V><S><I><S><E><E><R><Q><S><L><A><E><N><S><G><T><T><V><V><Y><N><P><Y><A><A><L><S><I><E><Q><Q><R><Q><K><L><P><V><F><K><L><R><N><H><I><L><Y><L><I><E><N><Y><Q><T><V><V><I><V><G><E><T><G><C><G><K><S><T><Q><I><P><Q><Y><L><A><E><A><G><W><T><A><E><G><R><V><V><G><V><T><Q><P><R><R><V><A><A><V><T><V><A><G><R><V><A><E><E><R><G><A><V><L><G><H><E><V><G><Y><C><I><R><F><D><D><C><T><D><Q><L><A><T><R><I><K><F><L><T><D><G><M><L><V><R><E><M><M><V><D><P><L><L><T><K><Y><S><V><I><M><L><D><E><A><H><E><R><T><L><Y><T><D><I><A><I><G><L><L><K><K><I><Q><K><K><R><G><D><L><R><L><I><V><A><S><A><T><L><D><A><D><K><F><R><D><F><F><N><Q><N><E><T><S><D><P><A><R><D><T><C><V><I><L><T><V><E><G><R><T><F><P><V><D><I><F><Y><L><Q><S><P><V><P><D><Y><I><K><S><T><V><E><T><V><V><K><I><H><Q><T><E><G><D><G><D><V><L><A><F><L><T><G><Q><E><E><V><E><T><V><V><S><M><L><I><E><Q><A><R><A><L><A><R><T><G><M><K><R><H><L><R><V><L><P><M><Y><A><G><L><P><S><F><E><Q><M><K><V><F><E><R><V><S><R><S><V><R><K><V><I><V><A><T><N><V><A><E><T><S><I><T><I><S><G><I><V><Y><V><I><D><C><G><F><V><K><L><R><A><Y><N><P><R><T><A><I><E><C><L><V><V><V><P><V><S><Q><A><S><A><N><Q><R><A><G><R><G><G><R><S><R><S><G><K><C><Y><R><L><Y><T><E><E><A><F><D><K><L><P><Q><S><T><V><P><E><M><Q><R><S><N><L><A><P><V><I><L><Q><L><K><A><L><G><I><D><N><V><L><R><F><H><F><M><S><P><P><P><A><Q><S><M><V><Q><A><L><E><L><L><Y><A><L><G><G><L><D><K><D><C><R><L><T><E><P><L><G><M><R><I><A><E><F><P><L><N><P><M><F><A><K><M><L><L><E><S><G><N><F><G><C><S><Q><E><I><L><S><I><A><A><M><M><Q><I><Q><N><I><F><V><V><P><P><N><Q><K><S><H><A><I><R><V><H><R><K><F><A><V><E><E><G><D><H><L><T><M><L><N><I><Y><E><A><F><I><K><H><N><K><D><S><K><W><C><Q><E><H><F><L><N><Y><K><G><L><V><R><A><A><T><V><R><E><Q><L><K><K><L><L><V><K><F><Q><V><P><R><K><S><S><E><G><D><P><D><L><V><L><R><C><I><V><S><G><F><F><A><N><A><A><R><F><H><S><T><G><A><Y><R><T><I><R><D><D><H><E><L><H><I><H><P><A><S><V><L><Y><A><E><K><P><P><R><W><V><I><Y><N><E><V><I><Q><T><S><K><Y><Y><M><R><D><V><T><A><I><E><S><A><W><L><L><E><L><A><P><H><F><Y><Q><Q><G><T><H><L><S><L><K><A><K><R><A><K><V><Q><D><P> | May be involved in pre-mRNA splicing.<BOP> | Q9H5Z1 |
O43293 | DAPK3_HUMAN | Zipper-interacting protein kinase | Homo | <M><S><T><F><R><Q><E><D><V><E><D><H><Y><E><M><G><E><E><L><G><S><G><Q><F><A><I><V><R><K><C><R><Q><K><G><T><G><K><E><Y><A><A><K><F><I><K><K><R><R><L><S><S><S><R><R><G><V><S><R><E><E><I><E><R><E><V><N><I><L><R><E><I><R><H><P><N><I><I><T><L><H><D><I><F><E><N><K><T><D><V><V><L><I><L><E><L><V><S><G><G><E><L><F><D><F><L><A><E><K><E><S><L><T><E><D><E><A><T><Q><F><L><K><Q><I><L><D><G><V><H><Y><L><H><S><K><R><I><A><H><F><D><L><K><P><E><N><I><M><L><L><D><K><N><V><P><N><P><R><I><K><L><I><D><F><G><I><A><H><K><I><E><A><G><N><E><F><K><N><I><F><G><T><P><E><F><V><A><P><E><I><V><N><Y><E><P><L><G><L><E><A><D><M><W><S><I><G><V><I><T><Y><I><L><L><S><G><A><S><P><F><L><G><E><T><K><Q><E><T><L><T><N><I><S><A><V><N><Y><D><F><D><E><E><Y><F><S><N><T><S><E><L><A><K><D><F><I><R><R><L><L><V><K><D><P><K><R><R><M><T><I><A><Q><S><L><E><H><S><W><I><K><A><I><R><R><R><N><V><R><G><E><D><S><G><R><K><P><E><R><R><R><L><K><T><T><R><L><K><E><Y><T><I><K><S><H><S><S><L><P><P><N><N><S><Y><A><D><F><E><R><F><S><K><V><L><E><E><A><A><A><A><E><E><G><L><R><E><L><Q><R><S><R><R><L><C><H><E><D><V><E><A><L><A><A><I><Y><E><E><K><E><A><W><Y><R><E><E><S><D><S><L><G><Q><D><L><R><R><L><R><Q><E><L><L><K><T><E><A><L><K><R><Q><A><Q><E><E><A><K><G><A><L><L><G><T><S><G><L><K><R><R><F><S><R><L><E><N><R><Y><E><A><L><A><K><Q><V><A><S><E><M><R><F><V><Q><D><L><V><R><A><L><E><Q><E><K><L><Q><G><V><E><C><G><L><R> | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics | O43293 |
Q92530 | PSMF1_HUMAN | Proteasome inhibitor PI31 subunit | Homo | <M><A><G><L><E><V><L><F><A><S><A><A><P><A><I><T><C><R><Q><D><A><L><V><C><F><L><H><W><E><V><V><T><H><G><Y><F><G><L><G><V><G><D><Q><P><G><P><N><D><K><K><S><E><L><L><P><A><G><W><N><N><N><K><D><L><Y><V><L><R><Y><E><Y><K><D><G><S><R><K><L><L><V><K><A><I><T><V><E><S><S><M><I><L><N><V><L><E><Y><G><S><Q><Q><V><A><D><L><T><L><N><L><D><D><Y><I><D><A><E><H><L><G><D><F><H><R><T><Y><K><N><S><E><E><L><R><S><R><I><V><S><G><I><I><T><P><I><H><E><Q><W><E><K><A><N><V><S><S><P><H><R><E><F><P><P><A><T><A><R><E><V><D><P><L><R><I><P><P><H><H><P><H><T><S><R><Q><P><P><W><C><D><P><L><G><P><F><V><V><G><G><E><D><L><D><P><F><G><P><R><R><G><G><M><I><V><D><P><L><R><S><G><F><P><R><A><L><I><D><P><S><S><G><L><P><N><R><L><P><P><G><A><V><P><P><G><A><R><F><D><P><F><G><P><I><G><T><S><P><P><G><P><N><P><D><H><L><P><P><P><G><Y><D><D><M><Y><L> | Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.<BOP> | Q92530 |
Q9NPD3 | EXOS4_HUMAN | p12A | Homo | <M><A><G><L><E><L><L><S><D><Q><G><Y><R><V><D><G><R><R><A><G><E><L><R><K><I><Q><A><R><M><G><V><F><A><Q><A><D><G><S><A><Y><I><E><Q><G><N><T><K><A><L><A><V><V><Y><G><P><H><E><I><R><G><S><R><A><R><A><L><P><D><R><A><L><V><N><C><Q><Y><S><S><A><T><F><S><T><G><E><R><K><R><R><P><H><G><D><R><K><S><C><E><M><G><L><Q><L><R><Q><T><F><E><A><A><I><L><T><Q><L><H><P><R><S><Q><I><D><I><Y><V><Q><V><L><Q><A><D><G><G><T><Y><A><A><C><V><N><A><A><T><L><A><V><L><D><A><G><I><P><M><R><D><F><V><C><A><C><S><A><G><F><V><D><G><T><A><L><A><D><L><S><H><V><E><E><A><A><G><G><P><Q><L><A><L><A><L><L><P><A><S><G><Q><I><A><L><L><E><M><D><A><R><L><H><E><D><H><L><E><R><V><L><E><A><A><A><Q><A><A><R><D><V><H><T><L><L><D><R><V><V><R><Q><H><V><R><E><A><S><I><L><L><G><D> | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Ex | Q9NPD3 |
Q96CN5 | LRC45_HUMAN | Leucine-rich repeat-containing protein 45 | Homo | <M><E><E><F><R><R><S><Y><S><R><L><C><R><E><S><G><A><E><P><Q><E><A><V><L><Q><Q><L><H><Q><L><P><R><G><R><L><D><L><A><T><Q><S><L><T><V><E><T><C><R><A><L><G><K><L><L><P><R><E><T><L><C><T><E><L><V><L><S><D><C><M><L><S><E><E><G><A><T><L><L><L><R><G><L><C><A><N><T><V><L><R><F><L><D><L><K><G><N><N><L><R><A><A><G><A><E><A><L><G><K><L><L><Q><Q><N><K><S><I><Q><S><L><T><L><E><W><N><S><L><G><T><W><D><D><A><F><A><T><F><C><G><G><L><A><A><N><G><A><L><Q><R><L><D><L><R><N><N><Q><I><S><H><K><G><A><E><E><L><A><L><A><L><K><G><N><T><T><L><Q><Q><L><D><L><R><W><N><N><V><G><L><L><G><G><R><A><L><M><N><C><L><P><S><N><R><T><L><W><R><L><D><L><A><G><N><N><I><P><G><D><V><L><R><A><V><E><Q><A><M><G><H><S><Q><D><R><L><T><T><F><Q><E><N><Q><A><R><T><H><V><L><S><K><E><V><Q><H><L><R><E><E><K><S><K><Q><F><L><D><L><M><E><T><I><D><K><Q><R><E><E><M><A><K><S><S><R><A><S><A><A><R><V><G><Q><L><Q><E><A><L><N><E><R><H><S><I><I><N><A><L><K><A><K><L><Q><M><T><E><A><A><L><A><L><S><E><Q><K><A><Q><D><L><G><E><L><L><A><T><A><E><Q><E><Q><L><S><L><S><Q><R><Q><A><K><E><L><K><L><E><Q><Q><E><A><A><E><R><E><S><K><L><L><R><D><L><S><A><A><N><E><K><N><L><L><L><Q><N><Q><V><D><E><L><E><R><K><F><R><C><Q><Q><E><Q><L><F><Q><T><R><Q><E><M><T><S><M><S><A><E><L><K><M><R><A><I><Q><A><E><E><R><L><D><M><E><K><R><R><C><R><Q><S><L><E><D><S><E><S><L><R><I><K><E><V><E><H><M><T><R><H><L><E><E><S><E><K><A><M><Q><E><R><V><Q><R><L><E><A><A><R><L><S><L><E><E><E><L><S><R><V><K><A><A><A><L><S><E><R><G><Q><A><E><E><E><L><I><K><A><K><S><Q><A><R><L><E><E><Q><Q><R><L><A><H><L><E><D><K><L><R><L><L><A><Q><A><R><D><E><A><Q><G><A><C><L><Q><Q><K><Q><V><V><A><E><A><Q><T><R><V><S><Q><L><G><L><Q><V><E><G><L><R><R><R><L><E><E><L><Q><Q><E><L><S><L><K><D><Q><E><R><V><A><E><V><S><R><V><R><V><E><L><Q><E><Q><N><G><R><L><Q><A><E><L><A><A><Q><E><A><L><R><E><K><A><A><A><L><E><R><Q><L><K><V><M><A><S><D><H><R><E><A><L><L><D><R><E><S><E><N><A><S><L><R><E><K><L><R><L><R><E><A><E><I><A><R><I><R><D><E><E><A><Q><R><A><S><F><L><Q><N><A><V><L><A><Y><V><Q><A><S><P><V><R><T><L><S><P><P><K> | Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.<BOP> | Q96CN5 |
P54107 | CRIS1_HUMAN | Acidic epididymal glycoprotein homolog | Homo | <M><E><I><K><H><L><L><F><L><V><A><A><A><C><L><L><P><M><L><S><M><K><K><K><S><A><R><D><Q><F><N><K><L><V><T><D><L><P><N><V><Q><E><E><I><V><N><I><H><N><A><L><R><R><R><V><V><P><P><A><S><N><M><L><K><M><S><W><S><E><E><A><A><Q><N><A><R><I><F><S><K><Y><C><D><M><T><E><S><N><P><L><E><R><R><L><P><N><T><F><C><G><E><N><M><H><M><T><S><Y><P><V><S><W><S><S><V><I><G><V><W><Y><S><E><S><T><S><F><K><H><G><E><W><T><T><T><D><D><D><I><T><T><D><H><Y><T><Q><I><V><W><A><T><S><Y><L><I><G><C><A><I><A><S><C><R><Q><Q><G><S><P><R><Y><L><Y><V><C><H><Y><C><H><E><G><N><D><P><E><T><K><N><E><P><Y><K><T><G><V><P><C><E><A><C><P><S><N><C><E><D><K><L><C><T><N><P><C><I><Y><Y><D><E><Y><F><D><C><D><I><Q><V><H><Y><L><G><C><N><H><S><T><T><I><L><F><C><K><A><T><C><L><C><D><T><E><I><K> | May have a role in sperm-egg fusion and maturation.<BOP> | P54107 |
P0CAP2 | GRL1A_HUMAN | Glutamate receptor-like protein 1A | Homo | <M><C><S><L><P><R><G><F><E><P><Q><A><P><E><D><L><A><Q><R><S><L><V><E><L><R><E><M><L><K><R><Q><E><R><L><L><R><N><E><K><F><I><C><K><L><P><D><K><G><K><K><I><F><D><S><F><A><K><L><K><A><A><I><A><E><C><E><E><V><R><R><K><S><E><L><F><N><P><V><S><L><D><C><K><L><R><Q><K><A><I><A><E><V><D><V><G><T><D><K><A><Q><N><S><D><P><I><L><D><T><S><S><L><V><P><G><C><S><S><V><D><N><I><K><S><S><Q><T><S><Q><N><Q><G><L><G><R><P><T><L><E><G><D><E><E><T><S><E><V><E><Y><T><V><N><K><G><P><A><S><S><N><R><D><R><V><P><P><S><S><E><A><S><E><H><H><P><R><H><R><V><S><S><Q><A><E><D><T><S><S><S><F><D><N><L><F><I><D><R><L><Q><R><I><T><I><A><D><Q><G><E><Q><Q><S><E><E><N><A><S><T><K><N><L><T><G><L><S><S><G><T><E><K><K><P><H><Y><M><E><V><L><E><M><R><A><K><N><P><V><P><Q><L><R><K><F><K><T><N><V><L><P><F><R><Q><N><D><S><S><S><H><C><Q><K><S><G><S><P><I><S><S><E><E><R><R><R><R><D><K><Q><H><L><D><D><I><T><A><A><R><L><L><P><L><H><H><M><P><T><Q><L><L><S><I><E><E><S><L><A><L><Q><K><Q><Q><K><Q><N><Y><E><E><M><Q><A><K><L><A><A><Q><K><L><A><E><R><L><N><I><K><M><R><S><Y><N><P><E><G><E><S><S><G><R><Y><R><E><V><R><D><E><D><D><D><W><S><S><D><E><F> | Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.<BOP> | P0CAP2 |
A0A0A0MT76 | LJ01_HUMAN | Immunoglobulin lambda joining 1 | Homo | <P><S><R><L><L><L><Q><P><S><P><Q><R><A><D><P><R><C><W><P><R><G><F><W><S><E><P><Q><S><L><C><Y><V><F><G><T><G><T><K><V><T><V><L> | J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0A0MT76 |
Q92784 | DPF3_HUMAN | Zinc finger protein cer-d4 | Homo | <M><A><T><V><I><H><N><P><L><K><A><L><G><D><Q><F><Y><K><E><A><I><E><H><C><R><S><Y><N><S><R><L><C><A><E><R><S><V><R><L><P><F><L><D><S><Q><T><G><V><A><Q><N><N><C><Y><I><W><M><E><K><R><H><R><G><P><G><L><A><P><G><Q><L><Y><T><Y><P><A><R><C><W><R><K><K><R><R><L><H><P><P><E><D><P><K><L><R><L><L><E><I><K><P><E><V><E><L><P><L><K><K><D><G><F><T><S><E><S><T><T><L><E><A><L><L><R><G><E><G><V><E><K><K><V><D><A><R><E><E><E><S><I><Q><E><I><Q><R><V><L><E><N><D><E><N><V><E><E><G><N><E><E><E><D><L><E><E><D><I><P><K><R><K><N><R><T><R><G><R><A><R><G><S><A><G><G><R><R><R><H><D><A><A><S><Q><E><D><H><D><K><P><Y><V><C><D><I><C><G><K><R><Y><K><N><R><P><G><L><S><Y><H><Y><A><H><T><H><L><A><S><E><E><G><D><E><A><Q><D><Q><E><T><R><S><P><P><N><H><R><N><E><N><H><R><P><Q><K><G><P><D><G><T><V><I><P><N><N><Y><C><D><F><C><L><G><G><S><N><M><N><K><K><S><G><R><P><E><E><L><V><S><C><A><D><C><G><R><S><G><H><P><T><C><L><Q><F><T><L><N><M><T><E><A><V><K><T><Y><K><W><Q><C><I><E><C><K><S><C><I><L><C><G><T><S><E><N><D><D><Q><L><L><F><C><D><D><C><D><R><G><Y><H><M><Y><C><L><N><P><P><V><A><E><P><P><E><G><S><W><S><C><H><L><C><W><E><L><L><K><E><K><A><S><A><F><G><C><Q><A> | Acts as a regulator of myogenesis in cooperation with HDGFL2 . Mediates the interaction of HDGFL2 with the BAF complex . HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters .<BOP> | Q92784 |
P25445 | TNR6_HUMAN | FASLG receptor | Homo | <M><L><G><I><W><T><L><L><P><L><V><L><T><S><V><A><R><L><S><S><K><S><V><N><A><Q><V><T><D><I><N><S><K><G><L><E><L><R><K><T><V><T><T><V><E><T><Q><N><L><E><G><L><H><H><D><G><Q><F><C><H><K><P><C><P><P><G><E><R><K><A><R><D><C><T><V><N><G><D><E><P><D><C><V><P><C><Q><E><G><K><E><Y><T><D><K><A><H><F><S><S><K><C><R><R><C><R><L><C><D><E><G><H><G><L><E><V><E><I><N><C><T><R><T><Q><N><T><K><C><R><C><K><P><N><F><F><C><N><S><T><V><C><E><H><C><D><P><C><T><K><C><E><H><G><I><I><K><E><C><T><L><T><S><N><T><K><C><K><E><E><G><S><R><S><N><L><G><W><L><C><L><L><L><L><P><I><P><L><I><V><W><V><K><R><K><E><V><Q><K><T><C><R><K><H><R><K><E><N><Q><G><S><H><E><S><P><T><L><N><P><E><T><V><A><I><N><L><S><D><V><D><L><S><K><Y><I><T><T><I><A><G><V><M><T><L><S><Q><V><K><G><F><V><R><K><N><G><V><N><E><A><K><I><D><E><I><K><N><D><N><V><Q><D><T><A><E><Q><K><V><Q><L><L><R><N><W><H><Q><L><H><G><K><K><E><A><Y><D><T><L><I><K><D><L><K><K><A><N><L><C><T><L><A><E><K><I><Q><T><I><I><L><K><D><I><T><S><D><S><E><N><S><N><F><R><N><E><I><Q><S><L><V> | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).<BOP> | P25445 |
Q68DI1 | ZN776_HUMAN | Zinc finger protein 776 | Homo | <M><A><A><A><A><L><R><P><P><A><Q><G><T><V><T><F><E><D><V><A><V><N><F><S><Q><E><E><W><S><L><L><S><E><A><Q><R><C><L><Y><H><D><V><M><L><E><N><L><T><L><I><S><S><L><G><C><W><Y><G><A><K><D><E><T><P><S><K><Q><T><L><S><I><Q><Q><E><S><P><L><R><T><H><W><T><G><V><C><T><K><K><V><H><L><W><G><M><C><G><P><L><L><G><D><I><L><H><Q><G><T><Q><H><N><Q><K><L><N><G><F><G><A><Y><E><K><K><L><D><D><D><A><N><H><H><Q><D><Q><K><Q><H><I><G><E><K><S><Y><R><S><N><A><K><G><T><S><F><V><K><N><C><K><F><H><M><S><H><E><P><F><I><F><H><E><V><G><K><D><F><L><S><S><L><R><L><L><Q><Q><E><D><I><H><T><S><G><K><S><N><F><E><T><K><H><G><I><P><L><Q><G><G><K><T><H><Y><I><C><G><E><S><T><I><P><F><S><N><K><H><S><L><V><L><H><Q><R><L><L><P><R><E><G><P><Y><V><C><S><D><S><G><K><F><T><S><K><S><N><S><F><N><N><H><Q><G><V><R><T><G><K><R><P><Y><Q><C><G><Q><C><D><E><S><F><W><Y><K><A><H><L><T><E><H><Q><R><V><H><T><G><E><R><P><Y><E><C><G><E><C><D><K><S><F><S><H><K><H><S><L><V><D><H><Q><R><V><H><T><G><E><R><P><Y><E><C><D><E><C><G><K><S><F><S><H><K><R><S><L><V><H><H><Q><R><V><H><T><G><E><R><P><Y><Q><C><G><E><C><G><K><S><F><N><H><K><C><N><L><I><Q><H><Q><R><V><H><T><G><E><R><P><F><E><C><T><A><C><G><K><L><F><R><S><N><S><H><L><K><E><H><Q><R><V><H><T><G><E><R><P><Y><E><C><K><E><C><R><K><S><F><R><Y><K><S><H><L><T><E><H><Q><R><V><H><T><G><E><R><P><Y><E><C><R><E><C><G><K><C><F><H><Q><K><G><S><L><I><Q><H><Q><Q><I><H><S><G><E><R><P><H><E><C><G><E><C><G><K><C><F><H><Q><K><G><S><L><I><R><H><Q><Q><I><H><S><G><E><R><P><H><E><C><G><E><C><G><K><C><F><R><Q><K><G><N><L><I><K><H><Q><R><V><H><T><G><E><R><H><H><E><C> | May be involved in transcriptional regulation.<BOP> | Q68DI1 |
Q6ZMV8 | ZN730_HUMAN | Putative zinc finger protein 730 | Homo | <M><G><A><L><T><F><R><D><V><A><I><E><F><S><L><E><E><W><Q><C><L><D><T><E><Q><Q><N><L><Y><R><N><V><M><L><D><N><Y><R><N><L><V><F><L><G><I><A><V><S><K><P><D><L><I><T><C><L><E><Q><E><K><E><P><W><N><L><K><T><H><D><M><V><A><K><P><P><V><I><C><S><H><I><A><Q><D><L><W><P><E><Q><G><I><K><D><Y><F><Q><E><V><I><L><R><Q><Y><K><K><C><R><H><E><N><L><L><L><R><K><G><C><K><N><V><D><E><F><K><M><H><K><K><G><Y><N><R><H><N><Q><C><L><T><T><S><H><S><K><I><F><Q><C><D><K><Y><V><K><V><F><H><K><F><S><N><S><N><R><H><K><I><R><H><T><S><K><K><P><F><K><C><K><E><C><G><K><L><F><C><I><L><S><H><L><A><Q><H><K><K><I><H><T><G><E><K><S><Y><K><C><E><E><Y><G><K><A><F><N><E><S><S><N><C><T><T><H><K><R><I><T><E><K><K><P><Y><K><C><K><E><C><G><K><A><F><N><W><F><S><H><F><T><T><H><K><R><I><H><T><G><E><K><P><Y><Q><C><E><K><C><G><K><F><F><N><Q><S><T><N><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><Q><S><S><N><L><T><E><H><K><K><I><H><T><K><E><Q><P><Y><K><C><E><K><C><G><K><A><F><K><W><S><S><T><L><T><K><H><K><R><I><H><N><G><E><K><P><Y><K><C><E><E><C><G><K><A><F><N><R><S><S><T><L><N><R><H><K><I><T><H><T><G><G><K><P><Y><K><Y><K><E><C><G><K><A><F><N><Q><S><S><T><L><T><I><H><K><I><I><H><T><V><E><K><F><Y><K><C><E><E><C><G><K><A><F><S><R><I><S><H><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><K><C><E><E><C><G><R><A><F><N><Q><S><S><T><L><T><T><H><K><R><I><H><T><G><E><K><P><Y><E><C><E><E><C><G><K><A><F><N><R><S><S><T><L><T><T><H><K><I><I><H><S><G><E><K><I><Y><K><C><K><E><C><G><K><A><F><R><R><F><S><H><L><T><R><H><K><T><I><H><T> | May be involved in transcriptional regulation.<BOP> | Q6ZMV8 |
Q8WV24 | PHLA1_HUMAN | T-cell death-associated gene 51 protein | Homo | <M><R><R><A><P><A><A><E><R><L><L><E><L><G><F><P><P><R><C><G><R><Q><E><P><P><F><P><L><G><V><T><R><G><W><G><R><W><P><I><Q><K><R><R><E><G><A><R><P><V><P><F><S><E><R><S><Q><E><D><G><R><G><P><A><A><R><S><S><G><T><L><W><R><I><R><T><R><L><S><L><C><R><D><P><E><P><P><P><P><L><C><L><L><R><V><S><L><L><C><A><L><R><A><G><G><R><G><S><R><W><G><E><D><G><A><R><L><L><L><L><P><P><A><R><A><A><G><N><G><E><A><E><P><S><G><G><P><S><Y><A><G><R><M><L><E><S><S><G><C><K><A><L><K><E><G><V><L><E><K><R><S><D><G><L><L><Q><L><W><K><K><K><C><C><I><L><T><E><E><G><L><L><L><I><P><P><K><Q><L><Q><H><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><P><G><Q><G><P><A><E><P><S><Q><P><S><G><P><A><V><A><S><L><E><P><P><V><K><L><K><E><L><H><F><S><N><M><K><T><V><D><C><V><E><R><K><G><K><Y><M><Y><F><T><V><V><M><A><E><G><K><E><I><D><F><R><C><P><Q><D><Q><G><W><N><A><E><I><T><L><Q><M><V><Q><Y><K><N><R><Q><A><I><L><A><V><K><S><T><R><Q><K><Q><Q><H><L><V><Q><Q><Q><P><P><S><Q><P><Q><P><Q><P><Q><L><Q><P><Q><P><Q><P><Q><P><Q><P><Q><P><Q><P><Q><S><Q><P><Q><P><Q><P><Q><P><K><P><Q><P><Q><Q><L><H><P><Y><P><H><P><H><P><H><P><H><S><H><P><H><S><H><P><H><P><H><P><H><P><H><P><H><Q><I><P><H><P><H><P><Q><P><H><S><Q><P><H><G><H><R><L><L><R><S><T><S><N><S><A> | Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.<BOP> | Q8WV24 |
Q9P000 | COMD9_HUMAN | COMM domain-containing protein 9 | Homo | <M><A><A><L><T><A><E><H><F><A><A><L><Q><S><L><L><K><A><S><S><K><D><V><V><R><Q><L><C><Q><E><S><F><S><S><S><A><L><G><L><K><K><L><L><D><V><T><C><S><S><L><S><V><T><Q><E><E><A><E><E><L><L><Q><A><L><H><R><L><T><R><L><V><A><F><R><D><L><S><S><A><E><A><I><L><A><L><F><P><E><N><F><H><Q><N><L><K><N><L><L><T><K><I><I><L><E><H><V><S><T><W><R><T><E><A><Q><A><N><Q><I><S><L><P><R><L><V><D><L><D><W><R><V><D><I><K><T><S><S><D><S><I><S><R><M><A><V><P><T><C><L><L><Q><M><K><I><Q><E><D><P><S><L><C><G><D><K><P><S><I><S><A><V><T><V><E><L><S><K><E><T><L><D><T><M><L><D><G><L><G><R><I><R><D><Q><L><S><A><V><A><S><K> | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . May down-regulate activation of NF-kappa-B . Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits .<BOP> | Q9P000 |
A0A0G2JMI3 | HV692_HUMAN | Immunoglobulin heavy variable 1-69-2 | Homo | <M><D><C><T><W><R><I><L><L><L><V><A><A><A><T><G><T><H><A><E><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><A><T><V><K><I><S><C><K><V><S><G><Y><T><F><T><D><Y><Y><M><H><W><V><Q><Q><A><P><G><K><G><L><E><W><M><G><L><V><D><P><E><D><G><E><T><I><Y><A><E><K><F><Q><G><R><V><T><I><T><A><D><T><S><T><D><T><A><Y><M><E><L><S><S><L><R><S><E><D><T><A><V><Y><Y><C><A><T> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | A0A0G2JMI3 |
Q96BX8 | MOB3A_HUMAN | Mps one binder kinase activator-like 2A | Homo | <M><S><N><P><F><L><K><Q><V><F><N><K><D><K><T><F><R><P><K><R><K><F><E><P><G><T><Q><R><F><E><L><H><K><K><A><Q><A><S><L><N><A><G><L><D><L><R><L><A><V><Q><L><P><P><G><E><D><L><N><D><W><V><A><V><H><V><V><D><F><F><N><R><V><N><L><I><Y><G><T><I><S><D><G><C><T><E><Q><S><C><P><V><M><S><G><G><P><K><Y><E><Y><R><W><Q><D><E><H><K><F><R><K><P><T><A><L><S><A><P><R><Y><M><D><L><L><M><D><W><I><E><A><Q><I><N><N><E><D><L><F><P><T><N><V><G><T><P><F><P><K><N><F><L><Q><T><V><R><K><I><L><S><R><L><F><R><V><F><V><H><V><Y><I><H><H><F><D><R><I><A><Q><M><G><S><E><A><H><V><N><T><C><Y><K><H><F><Y><Y><F><V><K><E><F><G><L><I><D><T><K><E><L><E><P><L><K><E><M><T><A><R><M><C><H> | May regulate the activity of kinases.<BOP> | Q96BX8 |
Q6ECI4 | ZN470_HUMAN | Chondrogenesis zinc finger protein 1 | Homo | <M><K><S><Q><E><E><V><E><V><A><G><I><K><L><C><K><A><M><S><L><G><S><V><T><F><T><D><V><A><I><D><F><S><Q><D><E><W><E><W><L><N><L><A><Q><R><S><L><Y><K><K><V><M><L><E><N><Y><R><N><L><V><S><V><G><L><C><I><S><K><P><D><V><I><S><L><L><E><Q><E><K><D><P><W><V><I><K><G><G><M><N><R><G><L><C><P><D><L><E><C><V><W><V><T><K><S><L><S><L><N><Q><D><I><Y><E><E><K><L><P><P><A><I><I><M><E><R><L><K><S><Y><D><L><E><C><S><T><L><G><K><N><W><K><C><E><D><L><F><E><R><E><L><V><N><Q><K><T><H><F><R><Q><E><T><I><T><H><I><D><T><L><I><E><K><R><D><H><S><N><K><S><G><T><V><F><H><L><N><T><L><S><Y><I><K><Q><I><F><P><M><E><E><R><I><F><N><F><H><T><D><K><K><S><L><K><T><H><S><V><V><K><K><H><K><Q><D><R><G><E><K><K><L><L><K><C><N><D><C><E><K><I><F><S><K><I><S><T><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><S><Q><S><A><H><L><A><Q><H><Q><R><I><H><T><G><E><K><P><F><E><C><T><E><C><G><K><A><F><S><Q><N><A><H><L><V><Q><H><Q><R><V><H><T><G><E><K><P><Y><Q><C><K><Q><C><N><K><A><F><S><Q><L><A><H><L><A><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><S><D><C><S><S><L><A><H><H><R><R><I><H><T><G><K><R><P><Y><E><C><I><D><C><G><K><A><F><R><Q><N><A><S><L><I><R><H><R><R><Y><Y><H><T><G><E><K><P><F><D><C><I><D><C><G><K><A><F><T><D><H><I><G><L><I><Q><H><K><R><T><H><T><G><E><R><P><Y><K><C><N><V><C><G><K><A><F><S><H><G><S><S><L><T><V><H><Q><R><I><H><T><G><E><K><P><Y><E><C><N><I><C><E><K><A><F><S><H><R><G><S><L><T><L><H><Q><R><V><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><Q><S><T><H><L><A><H><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><S><K><T><F><S><Q><N><A><H><L><A><Q><H><Q><K><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><Q><I><A><H><L><V><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><I><E><C><G><K><A><F><S><D><G><S><Y><L><V><Q><H><Q><R><L><H><S><G><K><R><P><Y><E><C><L><E><C><G><K><A><F><R><Q><R><A><S><L><I><C><H><Q><R><C><H><T><G><E><K><P><Y><E><C><N><V><C><G><K><A><F><S><H><R><K><S><L><T><L><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><S><K><A><F><S><Q><V><A><H><L><T><L><H><K><R><I><H><T><G><E><R><P><Y><E><C><K><E><C><G><K><A><F><R><Q><S><V><H><L><A><H><H><Q><R><I><H><T><G><E><S><S><V><I><L><S><S><A><L><P><Y><H><Q><V><L> | May be involved in transcriptional regulation.<BOP> | Q6ECI4 |
A8MT33 | SYC1L_HUMAN | Meiosis-related protein | Homo | <M><A><G><K><L><K><P><L><N><V><E><A><P><E><A><T><E><E><A><E><G><Q><A><K><S><L><K><T><E><D><L><L><A><M><V><I><K><L><Q><K><E><G><S><L><E><P><Q><I><E><D><L><I><S><R><I><N><D><L><Q><Q><A><K><K><K><S><S><E><E><L><R><E><T><H><S><L><W><E><A><L><H><R><E><L><D><S><L><N><G><E><K><V><H><L><E><E><V><L><G><K><K><Q><E><A><L><R><I><L><Q><M><H><C><Q><E><K><E><S><E><A><Q><R><L><D><V><R><G><Q><L><E><D><L><M><G><Q><H><K><D><L><W><E><F><H><M><L><E><Q><R><L><A><R><E><I><R><A><L><E><R><S><K><E><Q><L><L><S><E><R><R><L><V><R><A><K><L><R><E><V><E><R><R><L><H><S><P><P><E><V><E><G><A><M><A><V><N><D><G><L><K><A><E><L><E><I><F><G><E><Q><V><R><S><A><P><E><V><G><A><G><E><G><E><A><G><P><E><L><P><R><A><R><D><E><E><D><P><E><P><P><V><A><A><P><D><A><L> | May be involved in meiosis.<BOP> | A8MT33 |
Q58FF3 | ENPLL_HUMAN | Putative heat shock protein 90 kDa beta member 2 | Homo | <M><A><E><T><I><Q><E><V><E><D><E><Y><K><A><F><C><K><S><F><S><K><E><S><D><D><P><V><A><C><I><H><F><T><A><E><G><E><V><T><F><K><S><I><L><F><V><P><T><F><V><P><R><G><L><F><D><E><Y><G><S><K><K><S><D><Y><I><K><L><Y><V><R><C><V><F><I><T><D><D><F><R><D><T><M><P><K><N><L><N><F><V><K><G><V><V><D><S><G><G><L><S><L><N><V><S><C><E><T><L><Q><Q><H><K><L><L><K><V><I><R><K><K><L><V><H><K><T><L><D><M><I><K><K><I><A><D><E><K><Y><N><D><T><F><W><K><E><F><G><T><N><I><K><L><G><V><I><E><D><H><S><N><R><T><C><L><A><K><L><L><R><F><Q><S><S><H><H><P><A><D><I><T><S><L><H><Q><D><V><E><R><M><K><E><K><Q><D><K><I><C><L><M><A><G><G><Y><E><V><I><Y><L><T><E><P><V><V><E><Y><C><I><Q><A><L><P><E><F><D><G><K><R><F><Q><N><V><A><K><E><G><V><K><F><D><D><S><E><K><T><K><E><S><H><E><A><V><E><K><E><F><E><P><L><P><N><W><V><K><D><K><A><I><K><D><K><I><E><K><A><M><V><S><Q><C><L><T><E><S><L><C><A><L><V><A><S><Q><Y><G><W><S><G><N><M><E><R><I><M><K><A><Q><A><Y><Q><T><G><K><G><I><S><T><N><Y><H><A><S><R><K><K><T><F><E><I><N><P><R><H><P><L><I><R><D><M><L><R><R><I><K><E><D><E><D><D><K><T><V><L><D><L><A><V><V><E><E><P><D><E><E><P><E><E><T><A><E><D><K><E><Q><D><K><D><K><E><M><D><V><G><T><D><E><E><K><Q><E><T><A><K><E><S><T><A><E><K><D><E><L> | Putative molecular chaperone.<BOP> | Q58FF3 |
Q9P086 | MED11_HUMAN | Mediator complex subunit 11 | Homo | <M><A><T><Y><S><L><A><N><E><R><L><R><A><L><E><D><I><E><R><E><I><G><A><I><L><Q><N><A><G><T><V><I><L><E><L><S><K><E><K><T><N><E><R><L><L><D><R><Q><A><A><A><F><T><A><S><V><Q><H><V><E><A><E><L><S><A><Q><I><R><Y><L><T><Q><V><A><T><G><Q><P><H><E><G><S><S><Y><S><S><R><K><D><C><Q><M><A><L><K><R><V><D><Y><A><R><L><K><L><S><D><V><A><R><T><C><E><Q><M><L><E><N> | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<BOP> | Q9P086 |
Q8WVT3 | TPC12_HUMAN | Trafficking of membranes and mitosis | Homo | <M><E><D><A><G><G><G><E><E><T><P><A><P><E><A><P><H><P><P><Q><L><A><P><P><E><E><Q><G><L><L><F><Q><E><E><T><I><D><L><G><G><D><E><F><G><S><E><E><N><E><T><A><S><E><G><S><S><P><L><A><D><K><L><N><E><H><M><M><E><S><V><L><I><S><D><S><P><N><S><E><G><D><A><G><D><L><G><R><V><R><D><E><A><E><P><G><G><E><G><D><P><G><P><E><P><A><G><T><P><S><P><S><G><E><A><D><G><D><C><A><P><E><D><A><A><P><S><S><G><G><A><P><R><Q><D><A><A><R><E><V><P><G><S><E><A><A><R><P><E><Q><E><P><P><V><A><E><P><V><P><V><C><T><I><F><S><Q><R><A><P><P><A><S><G><D><G><F><E><P><Q><M><V><K><S><P><S><F><G><G><A><S><E><A><S><A><R><T><P><P><Q><V><V><Q><P><S><P><S><L><S><T><F><F><G><D><T><A><A><S><H><S><L><A><S><D><F><F><D><S><F><T><T><S><A><F><I><S><V><S><N><P><G><A><G><S><P><A><P><A><S><P><P><P><L><A><V><P><G><T><E><G><R><P><E><P><V><A><M><R><G><P><Q><A><A><A><P><P><A><S><P><E><P><F><A><H><I><Q><A><V><F><A><G><S><D><D><P><F><A><T><A><L><S><M><S><E><M><D><R><R><N><D><A><W><L><P><G><E><A><T><R><G><V><L><R><A><V><A><T><Q><Q><R><G><A><V><F><V><D><K><E><N><L><T><M><P><G><L><R><F><D><N><I><Q><G><D><A><V><K><D><L><M><L><R><F><L><G><E><K><A><A><A><K><R><Q><V><L><N><A><D><S><V><E><Q><S><F><V><G><L><K><Q><L><I><S><C><R><N><W><R><A><A><V><D><L><C><G><R><L><L><T><A><H><G><Q><G><Y><G><K><S><G><L><L><T><S><H><T><T><D><S><L><Q><L><W><F><V><R><L><A><L><L><V><K><L><G><L><F><Q><N><A><E><M><E><F><E><P><F><G><N><L><D><Q><P><D><L><Y><Y><E><Y><Y><P><H><V><Y><P><G><R><R><G><S><M><V><P><F><S><M><R><I><L><H><A><E><L><Q><Q><Y><L><G><N><P><Q><E><S><L><D><R><L><H><K><V><K><T><V><C><S><K><I><L><A><N><L><E><Q><G><L><A><E><D><G><G><M><S><S><V><T><Q><E><G><R><Q><A><S><I><R><L><W><R><S><R><L><G><R><V><M><Y><S><M><A><N><C><L><L><L><M><K><D><Y><V><L><A><V><E><A><Y><H><S><V><I><K><Y><Y><P><E><Q><E><P><Q><L><L><S><G><I><G><R><I><S><L><Q><I><G><D><I><K><T><A><E><K><Y><F><Q><D><V><E><K><V><T><Q><K><L><D><G><L><Q><G><K><I><M><V><L><M><N><S><A><F><L><H><L><G><Q><N><N><F><A><E><A><H><R><F><F><T><E><I><L><R><M><D><P><R><N><A><V><A><N><N><N><A><A><V><C><L><L><Y><L><G><K><L><K><D><S><L><R><Q><L><E><A><M><V><Q><Q><D><P><R><H><Y><L><H><E><S><V><L><F><N><L><T><T><M><Y><E><L><E><S><S><R><S><M><Q><K><K><Q><A><L><L><E><A><V><A><G><K><E><G><D><S><F><N><T><Q><C><L><K><L><A> | Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage . Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores .<BOP> | Q8WVT3 |
Q969H4 | CNKR1_HUMAN | Connector enhancer of KSR-like | Homo | <M><E><P><V><E><T><W><T><P><G><K><V><A><T><W><L><R><G><L><D><D><S><L><Q><D><Y><P><F><E><D><W><Q><L><P><G><K><N><L><L><Q><L><C><P><Q><S><L><E><A><L><A><V><R><S><L><G><H><Q><E><L><I><L><G><G><V><E><Q><L><Q><A><L><S><S><R><L><Q><T><E><N><L><Q><S><L><T><E><G><L><L><G><A><T><H><D><F><Q><S><I><V><Q><G><C><L><G><D><C><A><K><T><P><I><D><V><L><C><A><A><V><E><L><L><H><E><A><D><A><L><L><F><W><L><S><R><Y><L><F><S><H><L><N><D><F><S><A><C><Q><E><I><R><D><L><L><E><E><L><S><Q><V><L><H><E><D><G><P><A><A><E><K><E><G><T><V><L><R><I><C><S><H><V><A><G><I><C><H><N><I><L><V><C><C><P><K><E><L><L><E><Q><K><A><V><L><E><Q><V><Q><L><D><S><P><L><G><L><E><I><H><T><T><S><N><C><Q><H><F><V><S><Q><V><D><T><Q><V><P><T><D><S><R><L><Q><I><Q><P><G><D><E><V><V><Q><I><N><E><Q><V><V><V><R><E><E><R><D><M><V><G><W><P><R><K><N><M><V><R><E><L><L><R><E><P><A><G><L><S><L><V><L><K><K><I><P><I><P><E><T><P><P><Q><T><P><P><Q><V><L><D><S><P><H><Q><R><S><P><S><L><S><L><A><P><L><S><P><R><A><P><S><E><D><V><F><A><F><D><L><S><S><N><P><S><P><G><P><S><P><A><W><T><D><S><A><S><L><G><P><E><P><L><P><I><P><P><E><P><P><A><I><L><P><A><G><V><A><G><T><P><G><L><P><E><S><P><D><K><S><P><V><G><R><K><K><S><K><G><L><A><T><R><L><S><R><R><R><V><S><C><R><E><L><G><R><P><D><C><D><G><W><L><L><L><R><K><A><P><G><G><F><M><G><P><R><W><R><R><R><W><F><V><L><K><G><H><T><L><Y><W><Y><R><Q><P><Q><D><E><K><A><E><G><L><I><N><V><S><N><Y><S><L><E><S><G><H><D><Q><K><K><K><Y><V><F><Q><L><T><H><D><V><Y><K><P><F><I><F><A><A><D><T><L><T><D><L><S><M><W><V><R><H><L><I><T><C><I><S><K><Y><Q><S><P><G><R><A><P><P><P><R><E><E><D><C><Y><S><E><T><E><A><E><D><P><D><D><E><A><G><S><H><S><A><S><P><S><P><A><Q><A><G><S><P><L><H><G><D><T><S><P><A><A><T><P><T><Q><R><S><P><R><T><S><F><G><S><L><T><D><S><S><E><E><A><L><E><G><M><V><R><G><L><R><Q><G><G><V><S><L><L><G><Q><P><Q><P><L><T><Q><E><Q><W><R><S><S><F><M><R><R><N><R><D><P><Q><L><N><E><R><V><H><R><V><R><A><L><Q><S><T><L><K><A><K><L><Q><E><L><Q><V><L><E><E><V><L><G><D><P><E><L><T><G><E><K><F><R><Q><W><K><E><Q><N><R><E><L><Y><S><E><G><L><G><A><W><G><V><A><Q><A><E><G><S><S><H><I><L><T><S><D><S><T><E><Q><S><P><H><S><L><P><S><D><P><E><E><H><S><H><L><C><P><L><T><S><E><S><S><L><R><P><P><D><L> | May function as an adapter protein or regulator of Ras signaling pathways.<BOP> | Q969H4 |
P62304 | RUXE_HUMAN | Sm protein E | Homo | <M><A><Y><R><G><Q><G><Q><K><V><Q><K><V><M><V><Q><P><I><N><L><I><F><R><Y><L><Q><N><R><S><R><I><Q><V><W><L><Y><E><Q><V><N><M><R><I><E><G><C><I><I><G><F><D><E><Y><M><N><L><V><L><D><D><A><E><E><I><H><S><K><T><K><S><R><K><Q><L><G><R><I><M><L><K><G><D><N><I><T><L><L><Q><S><V><S><N> | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome . Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes . Is also a component of the minor U12 spliceosome . As part of the U7 snRNP it is involved in histone 3'-end processing .<BOP> | P62304 |
P60508 | SYCY2_HUMAN | Transmembrane protein | Homo | <M><G><L><L><L><L><V><L><I><L><T><P><S><L><A><A><Y><R><H><P><D><F><P><L><L><E><K><A><Q><Q><L><L><Q><S><T><G><S><P><Y><S><T><N><C><W><L><C><T><S><S><S><T><E><T><P><G><T><A><Y><P><A><S><P><R><E><W><T><S><I><E><A><E><L><H><I><S><Y><R><W><D><P><N><L><K><G><L><M><R><P><A><N><S><L><L><S><T><V><K><Q><D><F><P><D><I><R><Q><K><P><P><I><F><G><P><I><F><T><N><I><N><L><M><G><I><A><P><I><C><V><M><A><K><R><K><N><G><T><N><V><G><T><L><P><S><T><V><C><N><V><T><F><T><V><D><S><N><Q><Q><T><Y><Q><T><Y><T><H><N><Q><F><R><H><Q><P><R><F><P><K><P><P><N><I><T><F><P><Q><G><T><L><L><D><K><S><S><R><F><C><Q><G><R><P><S><S><C><S><T><R><N><F><W><F><R><P><A><D><Y><N><Q><C><L><Q><I><S><N><L><S><S><T><A><E><W><V><L><L><D><Q><T><R><N><S><L><F><W><E><N><K><T><K><G><A><N><Q><S><Q><T><P><C><V><Q><V><L><A><G><M><T><I><A><T><S><Y><L><G><I><S><A><V><S><E><F><F><G><T><S><L><T><P><L><F><H><F><H><I><S><T><C><L><K><T><Q><G><A><F><Y><I><C><G><Q><S><I><H><Q><C><L><P><S><N><W><T><G><T><C><T><I><G><Y><V><T><P><D><I><F><I><A><P><G><N><L><S><L><P><I><P><I><Y><G><N><S><P><L><P><R><V><R><R><A><I><H><F><I><P><L><L><A><G><L><G><I><L><A><G><T><G><T><G><I><A><G><I><T><K><A><S><L><T><Y><S><Q><L><S><K><E><I><A><N><N><I><D><T><M><A><K><A><L><T><T><M><Q><E><Q><I><D><S><L><A><A><V><V><L><Q><N><R><R><G><L><D><M><L><T><A><A><Q><G><G><I><C><L><A><L><D><E><K><C><C><F><W><V><N><Q><S><G><K><V><Q><D><N><I><R><Q><L><L><N><Q><A><S><S><L><R><E><R><A><T><Q><G><W><L><N><W><E><G><T><W><K><W><F><S><W><V><L><P><L><T><G><P><L><V><S><L><L><L><L><L><L><F><G><P><C><L><L><N><L><I><T><Q><F><V><S><S><R><L><Q><A><I><K><L><Q><T><N><L><S><A><G><R><H><P><R><N><I><Q><E><S><P><F> | Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane .<BOP> | P60508 |
Q9NV31 | IMP3_HUMAN | BRMS2 | Homo | <M><V><R><K><L><K><F><H><E><Q><K><L><L><K><Q><V><D><F><L><N><W><E><V><T><D><H><N><L><H><E><L><R><V><L><R><R><Y><R><L><Q><R><R><E><D><Y><T><R><Y><N><Q><L><S><R><A><V><R><E><L><A><R><R><L><R><D><L><P><E><R><D><Q><F><R><V><R><A><S><A><A><L><L><D><K><L><Y><A><L><G><L><V><P><T><R><G><S><L><E><L><C><D><F><V><T><A><S><S><F><C><R><R><R><L><P><T><V><L><L><K><L><R><M><A><Q><H><L><Q><A><A><V><A><F><V><E><Q><G><H><V><R><V><G><P><D><V><V><T><D><P><A><F><L><V><T><R><S><M><E><D><F><V><T><W><V><D><S><S><K><I><K><R><H><V><L><E><Y><N><E><E><R><D><D><F><D><L><E><A> | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.<BOP> | Q9NV31 |
Q9H208 | O10A2_HUMAN | Olfactory receptor OR11-86 | Homo | <M><S><F><S><S><L><P><T><E><I><Q><S><L><L><F><L><T><F><L><T><I><Y><L><V><T><L><M><G><N><C><L><I><I><L><V><T><L><A><D><P><M><L><H><S><P><M><Y><F><F><L><R><N><L><S><F><L><E><I><G><F><N><L><V><I><V><P><K><M><L><G><T><L><L><A><Q><D><T><T><I><S><F><L><G><C><A><T><Q><M><Y><F><F><F><F><F><G><V><A><E><C><F><L><L><A><T><M><A><Y><D><R><Y><V><A><I><C><S><P><L><H><Y><P><V><I><M><N><Q><R><T><R><A><K><L><A><A><A><S><W><F><P><G><F><P><V><A><T><V><Q><T><T><W><L><F><S><F><P><F><C><G><T><N><K><V><N><H><F><F><C><D><S><P><P><V><L><R><L><V><C><A><D><T><A><L><F><E><I><Y><A><I><V><G><T><I><L><V><V><M><I><P><C><L><L><I><L><C><S><Y><T><H><I><A><A><A><I><L><K><I><P><S><A><K><G><K><N><K><A><F><S><T><C><S><S><H><L><L><V><V><S><L><F><Y><I><S><L><S><L><T><Y><F><R><P><K><S><N><N><S><P><E><G><K><K><L><L><S><L><S><Y><T><V><M><T><P><M><L><N><P><I><I><Y><S><L><R><N><N><E><V><K><N><A><L><S><R><T><V><S><K><A><L><A><L><R><N><C><I><P> | Odorant receptor.<BOP> | Q9H208 |
Q13951 | PEBB_HUMAN | SL3/AKV core-binding factor beta subunit | Homo | <M><P><R><V><V><P><D><Q><R><S><K><F><E><N><E><E><F><F><R><K><L><S><R><E><C><E><I><K><Y><T><G><F><R><D><R><P><H><E><E><R><Q><A><R><F><Q><N><A><C><R><D><G><R><S><E><I><A><F><V><A><T><G><T><N><L><S><L><Q><F><F><P><A><S><W><Q><G><E><Q><R><Q><T><P><S><R><E><Y><V><D><L><E><R><E><A><G><K><V><Y><L><K><A><P><M><I><L><N><G><V><C><V><I><W><K><G><W><I><D><L><Q><R><L><D><G><M><G><C><L><E><F><D><E><E><R><A><Q><Q><E><D><A><L><A><Q><Q><A><F><E><E><A><R><R><R><T><R><E><F><E><D><R><D><R><S><H><R><E><E><M><E><V><R><V><S><Q><L><L><A><V><T><G><K><K><T><T><R><P> | Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.<BOP> | Q13951 |
Q9Y5X3 | SNX5_HUMAN | Sorting nexin-5 | Homo | <M><A><A><V><P><E><L><L><Q><Q><Q><E><E><D><R><S><K><L><R><S><V><S><V><D><L><N><V><D><P><S><L><Q><I><D><I><P><D><A><L><S><E><R><D><K><V><K><F><T><V><H><T><K><T><T><L><P><T><F><Q><S><P><E><F><S><V><T><R><Q><H><E><D><F><V><W><L><H><D><T><L><I><E><T><T><D><Y><A><G><L><I><I><P><P><A><P><T><K><P><D><F><D><G><P><R><E><K><M><Q><K><L><G><E><G><E><G><S><M><T><K><E><E><F><A><K><M><K><Q><E><L><E><A><E><Y><L><A><V><F><K><K><T><V><S><S><H><E><V><F><L><Q><R><L><S><S><H><P><V><L><S><K><D><R><N><F><H><V><F><L><E><Y><D><Q><D><L><S><V><R><R><K><N><T><K><E><M><F><G><G><F><F><K><S><V><V><K><S><A><D><E><V><L><F><T><G><V><K><E><V><D><D><F><F><E><Q><E><K><N><F><L><I><N><Y><Y><N><R><I><K><D><S><C><V><K><A><D><K><M><T><R><S><H><K><N><V><A><D><D><Y><I><H><T><A><A><C><L><H><S><L><A><L><E><E><P><T><V><I><K><K><Y><L><L><K><V><A><E><L><F><E><K><L><R><K><V><E><G><R><V><S><S><D><E><D><L><K><L><T><E><L><L><R><Y><Y><M><L><N><I><E><A><A><K><D><L><L><Y><R><R><T><K><A><L><I><D><Y><E><N><S><N><K><A><L><D><K><A><R><L><K><S><K><D><V><K><L><A><E><A><H><Q><Q><E><C><C><Q><K><F><E><Q><L><S><E><S><A><K><E><E><L><I><N><F><K><R><K><R><V><A><A><F><R><K><N><L><I><E><M><S><E><L><E><I><K><H><A><R><N><N><V><S><L><L><Q><S><C><I><D><L><F><K><N><N> | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity . Involved in retrograde transport of lysosomal enzyme receptor IGF2R . May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer | Q9Y5X3 |
Q13202 | DUS8_HUMAN | Dual specificity protein phosphatase hVH-5 | Homo | <M><A><G><D><R><L><P><R><K><V><M><D><A><K><K><L><A><S><L><L><R><G><G><P><G><G><P><L><V><I><D><S><R><S><F><V><E><Y><N><S><W><H><V><L><S><S><V><N><I><C><C><S><K><L><V><K><R><R><L><Q><Q><G><K><V><T><I><A><E><L><I><Q><P><A><A><R><S><Q><V><E><A><T><E><P><Q><D><V><V><V><Y><D><Q><S><T><R><D><A><S><V><L><A><A><D><S><F><L><S><I><L><L><S><K><L><D><G><C><F><D><S><V><A><I><L><T><G><G><F><A><T><F><S><S><C><F><P><G><L><C><E><G><K><P><A><A><L><L><P><M><S><L><S><Q><P><C><L><P><V><P><S><V><G><L><T><R><I><L><P><H><L><Y><L><G><S><Q><K><D><V><L><N><K><D><L><M><T><Q><N><G><I><S><Y><V><L><N><A><S><N><S><C><P><K><P><D><F><I><C><E><S><R><F><M><R><V><P><I><N><D><N><Y><C><E><K><L><L><P><W><L><D><K><S><I><E><F><I><D><K><A><K><L><S><S><C><Q><V><I><V><H><C><L><A><G><I><S><R><S><A><T><I><A><I><A><Y><I><M><K><T><M><G><M><S><S><D><D><A><Y><R><F><V><K><D><R><R><P><S><I><S><P><N><F><N><F><L><G><Q><L><L><E><Y><E><R><S><L><K><L><L><A><A><L><Q><G><D><P><G><T><P><S><G><T><P><E><P><P><P><S><P><A><A><G><A><P><L><P><R><L><P><P><P><T><S><E><S><A><A><T><G><N><A><A><A><R><E><G><G><L><S><A><G><G><E><P><P><A><P><P><T><P><P><A><T><S><A><L><Q><Q><G><L><R><G><L><H><L><S><S><D><R><L><Q><D><T><N><R><L><K><R><S><F><S><L><D><I><K><S><A><Y><A><P><S><R><R><P><D><G><P><G><P><P><D><P><G><E><A><P><K><L><C><K><L><D><S><P><S><G><A><A><L><G><L><S><S><P><S><P><D><S><P><D><A><A><P><E><A><R><P><R><P><R><R><R><P><R><P><P><A><G><S><P><A><R><S><P><A><H><S><L><G><L><N><F><G><D><A><A><R><Q><T><P><R><H><G><L><S><A><L><S><A><P><G><L><P><G><P><G><Q><P><A><G><P><G><A><W><A><P><P><L><D><S><P><G><T><P><S><P><D><G><P><W><C><F><S><P><E><G><A><Q><G><A><G><G><V><L><F><A><P><F><G><R><A><G><A><P><G><P><G><G><G><S><D><L><R><R><R><E><A><A><R><A><E><P><R><D><A><R><T><G><W><P><E><E><P><A><P><E><T><Q><F><K><R><R><S><C><Q><M><E><F><E><E><G><M><V><E><G><R><A><R><G><E><E><L><A><A><L><G><K><Q><A><S><F><S><G><S><V><E><V><I><E><V><S> | Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.<BOP> | Q13202 |
Q5EBL8 | PDZ11_HUMAN | Plasma membrane calcium ATPase-interacting single-PDZ protein | Homo | <M><D><S><R><I><P><Y><D><D><Y><P><V><V><F><L><P><A><Y><E><N><P><P><A><W><I><P><P><H><E><R><V><H><H><P><D><Y><N><N><E><L><T><Q><F><L><P><R><T><I><T><L><K><K><P><P><G><A><Q><L><G><F><N><I><R><G><G><K><A><S><Q><L><G><I><F><I><S><K><V><I><P><D><S><D><A><H><R><A><G><L><Q><E><G><D><Q><V><L><A><V><N><D><V><D><F><Q><D><I><E><H><S><K><A><V><E><I><L><K><T><A><R><E><I><S><M><R><V><R><F><F><P><Y><N><Y><H><R><Q><K><E><R><T><V><H> | Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.<BOP> | Q5EBL8 |
Q14590 | ZN235_HUMAN | Zinc finger protein HZF6 | Homo | <M><T><K><F><Q><E><A><V><T><F><K><D><V><A><V><A><F><T><E><E><E><L><G><L><L><D><S><A><Q><R><K><L><Y><R><D><V><M><L><E><N><F><R><N><L><V><S><V><G><H><Q><S><F><K><P><D><M><I><S><Q><L><E><R><E><E><K><L><W><M><K><E><L><Q><T><Q><R><G><K><H><S><G><D><R><N><Q><N><E><M><A><T><L><H><K><A><G><L><R><C><F><S><L><G><E><L><S><C><W><Q><I><K><R><H><I><A><S><K><L><A><R><S><Q><D><S><M><I><N><I><E><G><K><S><S><Q><F><P><K><H><H><D><S><P><C><Q><V><G><A><G><E><S><I><Q><A><S><V><D><D><N><C><L><V><N><H><I><G><D><H><S><S><I><I><E><N><Q><E><F><P><T><G><K><V><P><N><S><W><S><K><I><Y><L><N><E><T><Q><N><Y><Q><R><S><C><K><Q><T><Q><M><K><N><K><L><C><I><F><A><P><Y><V><D><I><F><S><C><I><S><H><H><H><D><D><N><I><V><H><K><R><D><K><V><H><S><N><S><D><C><G><K><D><T><L><K><V><S><P><L><T><Q><R><S><I><H><T><G><Q><K><T><Y><Q><G><N><E><C><E><E><A><F><N><D><S><S><S><L><E><L><H><K><Q><V><H><L><G><K><K><S><P><A><C><S><T><H><E><K><D><T><S><Y><S><S><G><I><P><V><Q><Q><S><V><R><T><G><K><K><R><Y><W><C><H><E><C><G><K><G><F><S><Q><S><S><N><L><Q><T><H><Q><R><V><H><T><G><E><K><P><Y><T><C><H><E><C><G><K><S><F><N><Q><S><S><H><L><Y><A><H><L><P><I><H><T><G><E><K><P><Y><R><C><D><S><C><G><K><G><F><S><R><S><T><D><L><N><I><H><C><R><V><H><T><G><E><K><P><Y><K><C><E><V><C><G><K><G><F><T><Q><R><S><H><L><Q><A><H><E><R><I><H><T><G><E><K><P><Y><K><C><G><D><C><G><K><R><F><S><C><S><S><N><L><H><T><H><Q><R><V><H><T><E><E><K><P><Y><K><C><D><E><C><G><K><C><F><S><L><S><F><N><L><H><S><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><S><A><S><S><F><Q><S><H><Q><R><V><H><T><G><E><K><P><F><R><C><N><V><C><G><K><G><F><S><Q><S><S><Y><F><Q><A><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><V><C><G><K><R><F><N><W><S><L><N><L><H><N><H><Q><R><V><H><T><G><E><K><P><Y><K><C><E><E><C><G><K><G><F><S><Q><A><S><N><L><Q><A><H><Q><S><V><H><T><G><E><K><P><F><K><C><D><A><C><Q><K><R><F><S><Q><A><S><H><L><Q><A><H><Q><R><V><H><T><G><E><K><P><Y><K><C><D><T><C><G><K><A><F><S><Q><R><S><N><L><Q><V><H><Q><I><I><H><T><G><E><K><P><F><K><C><E><E><C><G><K><E><F><S><W><S><A><G><L><S><A><H><Q><R><V><H><T><G><E><K><P><Y><T><C><Q><Q><C><G><K><G><F><S><Q><A><S><H><F><H><T><H><Q><R><V><H><T><G><E><R><P><Y><I><C><D><V><C><C><K><G><F><S><Q><R><S><H><L><I><Y><H><Q><R><V><H><T><G><G><N><L> | May be involved in transcriptional regulation.<BOP> | Q14590 |
P57052 | RBM11_HUMAN | RNA-binding motif protein 11 | Homo | <M><F><P><A><Q><E><E><A><D><R><T><V><F><V><G><N><L><E><A><R><V><R><E><E><I><L><Y><E><L><F><L><Q><A><G><P><L><T><K><V><T><I><C><K><D><R><E><G><K><P><K><S><F><G><F><V><C><F><K><H><P><E><S><V><S><Y><A><I><A><L><L><N><G><I><R><L><Y><G><R><P><I><N><V><Q><Y><R><F><G><S><S><R><S><S><E><P><A><N><Q><S><F><E><S><C><V><K><I><N><S><H><N><Y><R><N><E><E><M><L><V><G><R><S><S><F><P><M><Q><Y><F><P><I><N><N><T><S><L><P><Q><E><Y><F><L><F><Q><K><M><Q><W><H><V><Y><N><P><V><L><Q><L><P><Y><Y><E><M><T><A><P><L><P><N><S><A><S><V><S><S><S><L><N><H><V><P><D><L><E><A><G><P><S><S><Y><K><W><T><H><Q><Q><P><S><D><S><D><L><Y><Q><M><T><A><P><L><P><N><S><A><S><V><S><S><S><L><N><H><V><P><D><L><E><A><G><P><S><S><Y><K><W><T><H><Q><Q><P><S><D><S><D><L><Y><Q><M><N><K><R><K><R><Q><K><Q><T><S><D><S><D><S><S><T><D><N><N><R><G><N><E><C><S><Q><K><F><R><K><S><K><K><K><K><R><Y> | Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.<BOP> | P57052 |
Q08AG5 | ZN844_HUMAN | Zinc finger protein 844 | Homo | <M><D><L><V><A><F><E><D><V><A><V><N><F><T><Q><E><E><W><S><L><L><D><P><S><Q><K><N><L><Y><R><E><V><M><Q><E><T><L><R><N><L><A><S><I><G><E><K><W><K><D><Q><N><I><E><D><Q><Y><K><N><P><R><N><N><L><R><S><L><L><G><E><R><V><D><E><N><T><E><E><N><H><C><G><E><T><S><S><Q><I><P><D><D><T><L><N><K><K><T><S><P><G><V><K><S><C><E><S><S><V><C><G><E><V><F><V><G><H><S><S><L><N><R><H><I><R><A><D><T><A><H><K><P><S><E><Y><Q><E><Y><G><Q><E><P><Y><K><C><Q><Q><R><K><K><A><F><R><C><H><P><S><F><Q><M><Q><E><K><A><H><T><G><E><K><L><Y><D><C><K><E><C><G><K><T><F><I><S><H><S><S><I><Q><R><H><M><I><M><H><N><G><D><G><T><Y><K><C><K><F><C><G><K><A><C><P><C><L><S><I><Y><L><I><H><E><R><V><H><T><G><E><K><P><Y><K><C><K><Q><C><G><K><A><F><S><Y><S><T><S><L><Q><I><H><E><R><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><G><S><P><N><S><L><Y><E><H><R><R><T><H><T><G><E><K><P><Y><E><C><K><Q><C><G><K><A><F><R><W><F><H><S><F><Q><I><H><E><R><T><H><S><E><E><K><A><Y><E><C><T><K><C><G><K><A><F><K><C><P><S><Y><L><C><R><H><E><V><T><H><S><G><K><K><P><C><E><C><K><Q><C><G><K><A><L><S><Y><L><N><F><Q><R><H><M><K><M><H><T><R><M><R><P><Y><K><C><K><T><V><E><K><P><L><I><L><P><V><R><F><E><D><M><K><E><L><T><L><E><R><N><L><M><N><A><S><T><V><V><K><P><S><I><V><P><V><P><F><T><I><M><K><G><L><T><L><E><R><N><P><M><N><V><S><S><V><V><K><P><S><F><L><P><L><P><F><D><I><M><K><G><L><T><L><E><R><N><R><M><S><V><S><N><V><G><K><P><S><D><L><P><H><T><F><K><C><M><E><G><L><T><L><K><R><N><P><M><N><V><S><S><V><V><K><P><S><F><F><P><L><P><F><D><I><M><K><G><L><T><L><E><R><N><P><M><S><V><S><N><V><G><K><P><S><H><L><P><H><T><F><K><C><M><K><G><L><T><L><E><S><N><C><M><N><L><N><N><V><K><K><P><L><D><L><S><E><T><F><K><F><M><K><R><H><T><L><E><R><N><P><I><R><N><M><E><K><H><S><T><I><S><L><P><F><K><Y><M><Q><Q><C><T><E><D><R><M><P><M><N><V><K><S><V><T><K><H><S><Y><L><P><R><S><F><E><Y><M><Q><E><H><T><L><E><R><N><P><M><N><V><R><N><A><E><K><R><S><I><I><F><L><L><C><V><Y><T><K><G><C><T><L><E><R><N><H><I><N><V><R><I><V><G><K><H><S><V><C><L><V><P><F><V><D><I><K><G><L><T><L><E> | May be involved in transcriptional regulation.<BOP> | Q08AG5 |
O75342 | LX12B_HUMAN | Epidermis-type lipoxygenase 12 | Homo | <M><A><T><Y><K><V><R><V><A><T><G><T><D><L><L><S><G><T><R><D><S><I><S><L><T><I><V><G><T><Q><G><E><S><H><K><Q><L><L><N><H><F><G><R><D><F><A><T><G><A><V><G><Q><Y><T><V><Q><C><P><Q><D><L><G><E><L><I><I><I><R><L><H><K><E><R><Y><A><F><F><P><K><D><P><W><Y><C><N><Y><V><Q><I><C><A><P><N><G><R><I><Y><H><F><P><A><Y><Q><W><M><D><G><Y><E><T><L><A><L><R><E><A><T><G><K><T><T><A><D><D><S><L><P><V><L><L><E><H><R><K><E><E><I><R><A><K><Q><D><F><Y><H><W><R><V><F><L><P><G><L><P><S><Y><V><H><I><P><S><Y><R><P><P><V><R><R><H><R><N><P><N><R><P><E><W><N><G><Y><I><P><G><F><P><I><L><I><N><F><K><A><T><K><F><L><N><L><N><L><R><Y><S><F><L><K><T><A><S><F><F><V><R><L><G><P><M><A><L><A><F><K><V><R><G><L><L><D><C><K><H><S><W><K><R><L><K><D><I><R><K><I><F><P><G><K><K><S><V><V><S><E><Y><V><A><E><H><W><A><E><D><T><F><F><G><Y><Q><Y><L><N><G><V><N><P><G><L><I><R><R><C><T><R><I><P><D><K><F><P><V><T><D><D><M><V><A><P><F><L><G><E><G><T><C><L><Q><A><E><L><E><K><G><N><I><Y><L><A><D><Y><R><I><M><E><G><I><P><T><V><E><L><S><G><R><K><Q><H><H><C><A><P><L><C><L><L><H><F><G><P><E><G><K><M><M><P><I><A><I><Q><L><S><Q><T><P><G><P><D><C><P><I><F><L><P><S><D><S><E><W><D><W><L><L><A><K><T><W><V><R><Y><A><E><F><Y><S><H><E><A><I><A><H><L><L><E><T><H><L><I><A><E><A><F><C><L><A><L><L><R><N><L><P><M><C><H><P><L><Y><K><L><L><I><P><H><T><R><Y><T><V><Q><I><N><S><I><G><R><A><V><L><L><N><E><G><G><L><S><A><K><G><M><S><L><G><V><E><G><F><A><G><V><M><V><R><A><L><S><E><L><T><Y><D><S><L><Y><L><P><N><D><F><V><E><R><G><V><Q><D><L><P><G><Y><Y><Y><R><D><D><S><L><A><V><W><N><A><L><E><K><Y><V><T><E><I><I><T><Y><Y><Y><P><S><D><A><A><V><E><G><D><P><E><L><Q><S><W><V><Q><E><I><F><K><E><C><L><L><G><R><E><S><S><G><F><P><R><C><L><R><T><V><P><E><L><I><R><Y><V><T><I><V><I><Y><T><C><S><A><K><H><A><A><V><N><T><G><Q><M><E><F><T><A><W><M><P><N><F><P><A><S><M><R><N><P><P><I><Q><T><K><G><L><T><T><L><E><T><F><M><D><T><L><P><D><V><K><T><T><C><I><T><L><L><V><L><W><T><L><S><R><E><P><D><D><R><R><P><L><G><H><F><P><D><I><H><F><V><E><E><A><P><R><R><S><I><E><A><F><R><Q><R><L><N><Q><I><S><H><D><I><R><Q><R><N><K><C><L><P><I><P><Y><Y><Y><L><D><P><V><L><I><E><N><S><I><S><I> | Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species . In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins . Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss . May also play a role in the regulation of the expression of airway mucins .<BOP> | O75342 |
Q01844 | EWS_HUMAN | Ewing sarcoma breakpoint region 1 protein | Homo | <M><A><S><T><D><Y><S><T><Y><S><Q><A><A><A><Q><Q><G><Y><S><A><Y><T><A><Q><P><T><Q><G><Y><A><Q><T><T><Q><A><Y><G><Q><Q><S><Y><G><T><Y><G><Q><P><T><D><V><S><Y><T><Q><A><Q><T><T><A><T><Y><G><Q><T><A><Y><A><T><S><Y><G><Q><P><P><T><G><Y><T><T><P><T><A><P><Q><A><Y><S><Q><P><V><Q><G><Y><G><T><G><A><Y><D><T><T><T><A><T><V><T><T><T><Q><A><S><Y><A><A><Q><S><A><Y><G><T><Q><P><A><Y><P><A><Y><G><Q><Q><P><A><A><T><A><P><T><R><P><Q><D><G><N><K><P><T><E><T><S><Q><P><Q><S><S><T><G><G><Y><N><Q><P><S><L><G><Y><G><Q><S><N><Y><S><Y><P><Q><V><P><G><S><Y><P><M><Q><P><V><T><A><P><P><S><Y><P><P><T><S><Y><S><S><T><Q><P><T><S><Y><D><Q><S><S><Y><S><Q><Q><N><T><Y><G><Q><P><S><S><Y><G><Q><Q><S><S><Y><G><Q><Q><S><S><Y><G><Q><Q><P><P><T><S><Y><P><P><Q><T><G><S><Y><S><Q><A><P><S><Q><Y><S><Q><Q><S><S><S><Y><G><Q><Q><S><S><F><R><Q><D><H><P><S><S><M><G><V><Y><G><Q><E><S><G><G><F><S><G><P><G><E><N><R><S><M><S><G><P><D><N><R><G><R><G><R><G><G><F><D><R><G><G><M><S><R><G><G><R><G><G><G><R><G><G><M><G><S><A><G><E><R><G><G><F><N><K><P><G><G><P><M><D><E><G><P><D><L><D><L><G><P><P><V><D><P><D><E><D><S><D><N><S><A><I><Y><V><Q><G><L><N><D><S><V><T><L><D><D><L><A><D><F><F><K><Q><C><G><V><V><K><M><N><K><R><T><G><Q><P><M><I><H><I><Y><L><D><K><E><T><G><K><P><K><G><D><A><T><V><S><Y><E><D><P><P><T><A><K><A><A><V><E><W><F><D><G><K><D><F><Q><G><S><K><L><K><V><S><L><A><R><K><K><P><P><M><N><S><M><R><G><G><L><P><P><R><E><G><R><G><M><P><P><P><L><R><G><G><P><G><G><P><G><G><P><G><G><P><M><G><R><M><G><G><R><G><G><D><R><G><G><F><P><P><R><G><P><R><G><S><R><G><N><P><S><G><G><G><N><V><Q><H><R><A><G><D><W><Q><C><P><N><P><G><C><G><N><Q><N><F><A><W><R><T><E><C><N><Q><C><K><A><P><K><P><E><G><F><L><P><P><P><F><P><P><P><G><G><D><R><G><R><G><G><P><G><G><M><R><G><G><R><G><G><L><M><D><R><G><G><P><G><G><M><F><R><G><G><R><G><G><D><R><G><G><F><R><G><G><R><G><M><D><R><G><G><F><G><G><G><R><R><G><G><P><G><G><P><P><G><P><L><M><E><Q><M><G><G><R><R><G><G><R><G><G><P><G><K><M><D><K><G><E><H><R><Q><E><R><R><D><R><P><Y> | Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.<BOP> | Q01844 |
P14652 | HXB2_HUMAN | K8 | Homo | <M><N><F><E><F><E><R><E><I><G><F><I><N><S><Q><P><S><L><A><E><C><L><T><S><F><P><A><V><L><E><T><F><Q><T><S><S><I><K><E><S><T><L><I><P><P><P><P><P><F><E><Q><T><F><P><S><L><Q><P><G><A><S><T><L><Q><R><P><R><S><Q><K><R><A><E><D><G><P><A><L><P><P><P><P><P><P><P><L><P><A><A><P><P><A><P><E><F><P><W><M><K><E><K><K><S><A><K><K><P><S><Q><S><A><T><S><P><S><P><A><A><S><A><V><P><A><S><G><V><G><S><P><A><D><G><L><G><L><P><E><A><G><G><G><G><A><R><R><L><R><T><A><Y><T><N><T><Q><L><L><E><L><E><K><E><F><H><F><N><K><Y><L><C><R><P><R><R><V><E><I><A><A><L><L><D><L><T><E><R><Q><V><K><V><W><F><Q><N><R><R><M><K><H><K><R><Q><T><Q><H><R><E><P><P><D><G><E><P><A><C><P><G><A><L><E><D><I><C><D><P><A><E><E><P><A><A><S><P><G><G><P><S><A><S><R><A><A><W><E><A><C><C><H><P><P><E><V><V><P><G><A><L><S><A><D><P><R><P><L><A><V><R><L><E><G><A><G><A><S><S><P><G><C><A><L><R><G><A><G><G><L><E><P><G><P><L><P><E><D><V><F><S><G><R><Q><D><S><P><F><L><P><D><L><N><F><F><A><A><D><S><C><L><Q><L><S><G><G><L><S><P><S><L><Q><G><S><L><D><S><P><V><P><F><S><E><E><E><L><D><F><F><T><S><T><L><C><A><I><D><L><Q><F><P> | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.<BOP> | P14652 |
P27918 | PROP_HUMAN | Complement factor P | Homo | <M><I><T><E><G><A><Q><A><P><R><L><L><L><P><P><L><L><L><L><L><T><L><P><A><T><G><S><D><P><V><L><C><F><T><Q><Y><E><E><S><S><G><K><C><K><G><L><L><G><G><G><V><S><V><E><D><C><C><L><N><T><A><F><A><Y><Q><K><R><S><G><G><L><C><Q><P><C><R><S><P><R><W><S><L><W><S><T><W><A><P><C><S><V><T><C><S><E><G><S><Q><L><R><Y><R><R><C><V><G><W><N><G><Q><C><S><G><K><V><A><P><G><T><L><E><W><Q><L><Q><A><C><E><D><Q><Q><C><C><P><E><M><G><G><W><S><G><W><G><P><W><E><P><C><S><V><T><C><S><K><G><T><R><T><R><R><R><A><C><N><H><P><A><P><K><C><G><G><H><C><P><G><Q><A><Q><E><S><E><A><C><D><T><Q><Q><V><C><P><T><H><G><A><W><A><T><W><G><P><W><T><P><C><S><A><S><C><H><G><G><P><H><E><P><K><E><T><R><S><R><K><C><S><A><P><E><P><S><Q><K><P><P><G><K><P><C><P><G><L><A><Y><E><Q><R><R><C><T><G><L><P><P><C><P><V><A><G><G><W><G><P><W><G><P><V><S><P><C><P><V><T><C><G><L><G><Q><T><M><E><Q><R><T><C><N><H><P><V><P><Q><H><G><G><P><F><C><A><G><D><A><T><R><T><H><I><C><N><T><A><V><P><C><P><V><D><G><E><W><D><S><W><G><E><W><S><P><C><I><R><R><N><M><K><S><I><S><C><Q><E><I><P><G><Q><Q><S><R><G><R><T><C><R><G><R><K><F><D><G><H><R><C><A><G><Q><Q><Q><D><I><R><H><C><Y><S><I><Q><H><C><P><L><K><G><S><W><S><E><W><S><T><W><G><L><C><M><P><P><C><G><P><N><P><T><R><A><R><Q><R><L><C><T><P><L><L><P><K><Y><P><P><T><V><S><M><V><E><G><Q><G><E><K><N><V><T><F><W><G><R><P><L><P><R><C><E><E><L><Q><G><Q><K><L><V><V><E><E><K><R><P><C><L><H><V><P><A><C><K><D><P><E><E><E><E><L> | A positive regulator of the alternate pathway (AP) of complement . It binds to and stabilizes the C3- and C5-convertase enzyme complexes . Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) .<BOP> | P27918 |
P49286 | MTR1B_HUMAN | Melatonin receptor type 1B | Homo | <M><S><E><N><G><S><F><A><N><C><C><E><A><G><G><W><A><V><R><P><G><W><S><G><A><G><S><A><R><P><S><R><T><P><R><P><P><W><V><A><P><A><L><S><A><V><L><I><V><T><T><A><V><D><V><V><G><N><L><L><V><I><L><S><V><L><R><N><R><K><L><R><N><A><G><N><L><F><L><V><S><L><A><L><A><D><L><V><V><A><F><Y><P><Y><P><L><I><L><V><A><I><F><Y><D><G><W><A><L><G><E><E><H><C><K><A><S><A><F><V><M><G><L><S><V><I><G><S><V><F><N><I><T><A><I><A><I><N><R><Y><C><Y><I><C><H><S><M><A><Y><H><R><I><Y><R><R><W><H><T><P><L><H><I><C><L><I><W><L><L><T><V><V><A><L><L><P><N><F><F><V><G><S><L><E><Y><D><P><R><I><Y><S><C><T><F><I><Q><T><A><S><T><Q><Y><T><A><A><V><V><V><I><H><F><L><L><P><I><A><V><V><S><F><C><Y><L><R><I><W><V><L><V><L><Q><A><R><R><K><A><K><P><E><S><R><L><C><L><K><P><S><D><L><R><S><F><L><T><M><F><V><V><F><V><I><F><A><I><C><W><A><P><L><N><C><I><G><L><A><V><A><I><N><P><Q><E><M><A><P><Q><I><P><E><G><L><F><V><T><S><Y><L><L><A><Y><F><N><S><C><L><N><A><I><V><Y><G><L><L><N><Q><N><F><R><R><E><Y><K><R><I><L><L><A><L><W><N><P><R><H><C><I><Q><D><A><S><K><G><S><H><A><E><G><L><Q><S><P><A><P><P><I><I><G><V><Q><H><Q><A><D><A><L> | High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.<BOP> | P49286 |
O15254 | ACOX3_HUMAN | Pristanoyl-CoA oxidase | Homo | <M><A><S><T><V><E><G><G><D><T><A><L><L><P><E><F><P><R><G><P><L><D><A><Y><R><A><R><A><S><F><S><W><K><E><L><A><L><F><T><E><G><E><G><M><L><R><F><K><K><T><I><F><S><A><L><E><N><D><P><L><F><A><R><S><P><G><A><D><L><S><L><E><K><Y><R><E><L><N><F><L><R><C><K><R><I><F><E><Y><D><F><L><S><V><E><D><M><F><K><S><P><L><K><V><P><A><L><I><Q><C><L><G><M><Y><D><S><S><L><A><A><K><Y><L><L><H><S><L><V><F><G><S><A><V><Y><S><S><G><S><E><R><H><L><T><Y><I><Q><K><I><F><R><M><E><I><F><G><C><F><A><L><T><E><L><S><H><G><S><N><T><K><A><I><R><T><T><A><H><Y><D><P><A><T><E><E><F><I><I><H><S><P><D><F><E><A><A><K><F><W><V><G><N><M><G><K><T><A><T><H><A><V><V><F><A><K><L><C><V><P><G><D><Q><C><H><G><L><H><P><F><I><V><Q><I><R><D><P><K><T><L><L><P><M><P><G><V><M><V><G><D><I><G><K><K><L><G><Q><N><G><L><D><N><G><F><A><M><F><H><K><V><R><V><P><R><Q><S><L><L><N><R><M><G><D><V><T><P><E><G><T><Y><V><S><P><F><K><D><V><R><Q><R><F><G><A><S><L><G><S><L><S><S><G><R><V><S><I><V><S><L><A><I><L><N><L><K><L><A><V><A><I><A><L><R><F><S><A><T><R><R><Q><F><G><P><T><E><E><E><E><I><P><V><L><E><Y><P><M><Q><Q><W><R><L><L><P><Y><L><A><A><V><Y><A><L><D><H><F><S><K><S><L><F><L><D><L><V><E><L><Q><R><G><L><A><S><G><D><R><S><A><R><Q><A><E><L><G><R><E><I><H><A><L><A><S><A><S><K><P><L><A><S><W><T><T><Q><Q><G><I><Q><E><C><R><E><A><C><G><G><H><G><Y><L><A><M><N><R><L><G><V><L><R><D><D><N><D><P><N><C><T><Y><E><G><D><N><N><I><L><L><Q><Q><T><S><N><Y><L><L><G><L><L><A><H><Q><V><H><D><G><A><C><F><R><S><P><L><K><S><V><D><F><L><D><A><Y><P><G><I><L><D><Q><K><F><E><V><S><S><V><A><D><C><L><D><S><A><V><A><L><A><A><Y><K><W><L><V><C><Y><L><L><R><E><T><Y><Q><K><L><N><Q><E><K><R><S><G><S><S><D><F><E><A><R><N><K><C><Q><V><S><H><G><R><P><L><A><L><A><F><V><E><L><T><V><V><Q><R><F><H><E><H><V><H><Q><P><S><V><P><P><S><L><R><A><V><L><G><R><L><S><A><L><Y><A><L><W><S><L><S><R><H><A><A><L><L><Y><R><G><G><Y><F><S><G><E><Q><A><G><E><V><L><E><S><A><V><L><A><L><C><S><Q><L><K><D><D><A><V><A><L><V><D><V><I><A><P><P><D><F><V><L><D><S><P><I><G><R><A><D><G><E><L><Y><K><N><L><W><G><A><V><L><Q><E><S><K><V><L><E><R><A><S><W><W><P><E><F><S><V><N><K><P><V><I><G><S><L><K><S><K><L> | Oxidizes the CoA-esters of 2-methyl-branched fatty acids.<BOP> | O15254 |
Q9BR61 | ACBD6_HUMAN | Acyl-CoA-binding domain-containing protein 6 | Homo | <M><A><S><S><F><L><P><A><G><A><I><T><G><D><S><G><G><E><L><S><S><G><D><D><S><G><E><V><E><F><P><H><S><P><E><I><E><E><T><S><C><L><A><E><L><F><E><K><A><A><A><H><L><Q><G><L><I><Q><V><A><S><R><E><Q><L><L><Y><L><Y><A><R><Y><K><Q><V><K><V><G><N><C><N><T><P><K><P><S><F><F><D><F><E><G><K><Q><K><W><E><A><W><K><A><L><G><D><S><S><P><S><Q><A><M><Q><E><Y><I><A><V><V><K><K><L><D><P><G><W><N><P><Q><I><P><E><K><K><G><K><E><A><N><T><G><F><G><G><P><V><I><S><S><L><Y><H><E><E><T><I><R><E><E><D><K><N><I><F><D><Y><C><R><E><N><N><I><D><H><I><T><K><A><I><K><S><K><N><V><D><V><N><V><K><D><E><E><G><R><A><L><L><H><W><A><C><D><R><G><H><K><E><L><V><T><V><L><L><Q><H><R><A><D><I><N><C><Q><D><N><E><G><Q><T><A><L><H><Y><A><S><A><C><E><F><L><D><I><V><E><L><L><L><Q><S><G><A><D><P><T><L><R><D><Q><D><G><C><L><P><E><E><V><T><G><C><K><T><V><S><L><V><L><Q><R><H><T><T><G><K><A> | Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.<BOP> | Q9BR61 |
Q86WP2 | GPBP1_HUMAN | Vascular wall-linked protein | Homo | <M><A><Q><H><D><F><A><P><A><W><L><N><F><P><T><P><P><S><S><T><K><S><S><L><N><F><E><K><H><S><E><N><F><A><W><T><E><N><R><Y><D><V><N><R><R><R><H><N><S><S><D><G><F><D><S><A><I><G><R><P><N><G><G><N><F><G><R><K><E><K><N><G><W><R><T><H><G><R><N><G><T><E><N><I><N><H><R><G><G><Y><H><G><G><S><S><R><S><R><S><S><I><F><H><A><G><K><S><Q><G><L><H><E><N><N><I><P><D><N><E><T><G><R><K><E><D><K><R><E><R><K><Q><F><E><A><E><D><F><P><S><L><N><P><E><Y><E><R><E><P><N><H><N><K><S><L><A><A><G><V><W><E><Y><P><P><N><P><K><S><R><A><P><R><M><L><V><I><K><K><G><N><T><K><D><L><Q><L><S><G><F><P><V><V><G><N><L><P><S><Q><P><V><K><N><G><T><G><P><S><V><Y><K><G><L><V><P><K><P><A><A><P><P><T><K><P><T><Q><W><K><S><Q><T><K><E><N><K><V><G><T><S><F><P><H><E><S><T><F><G><V><G><N><F><N><A><F><K><S><T><A><K><N><F><S><P><S><T><N><S><V><K><E><C><N><R><S><N><S><S><S><P><V><D><K><L><N><Q><Q><P><R><L><T><K><L><T><R><M><R><T><D><K><K><S><E><F><L><K><A><L><K><R><D><R><V><E><E><E><H><E><D><E><S><R><A><G><S><E><K><D><D><D><S><F><N><L><H><N><S><N><S><T><H><Q><E><R><D><I><N><R><N><F><D><E><N><E><I><P><Q><E><N><G><N><A><S><V><I><S><Q><Q><I><I><R><S><S><T><F><P><Q><T><D><V><L><S><S><S><L><E><A><E><H><R><L><L><K><E><M><G><W><Q><E><D><S><E><N><D><E><T><C><A><P><L><T><E><D><E><M><R><E><F><Q><V><I><S><E><Q><L><Q><K><N><G><L><R><K><N><G><I><L><K><N><G><L><I><C><D><F><K><F><G><P><W><K><N><S><T><F><K><P><T><T><E><N><D><D><T><E><T><S><S><S><D><T><S><D><D><D><D><V> | Functions as a GC-rich promoter-specific transactivating transcription factor.<BOP> | Q86WP2 |
Q96EK5 | KBP_HUMAN | Kinesin family binding protein | Homo | <M><A><N><V><P><W><A><E><V><C><E><K><F><Q><A><A><L><A><L><S><R><V><E><L><H><K><N><P><E><K><E><P><Y><K><S><K><Y><S><A><R><A><L><L><E><E><V><K><A><L><L><G><P><A><P><E><D><E><D><E><R><P><E><A><E><D><G><P><G><A><G><D><H><A><L><G><L><P><A><E><V><V><E><P><E><G><P><V><A><Q><R><A><V><R><L><A><V><I><E><F><H><L><G><V><N><H><I><D><T><E><E><L><S><A><G><E><E><H><L><V><K><C><L><R><L><L><R><R><Y><R><L><S><H><D><C><I><S><L><C><I><Q><A><Q><N><N><L><G><I><L><W><S><E><R><E><E><I><E><T><A><Q><A><Y><L><E><S><S><E><A><L><Y><N><Q><Y><M><K><E><V><G><S><P><P><L><D><P><T><E><R><F><L><P><E><E><E><K><L><T><E><Q><E><R><S><K><R><F><E><K><V><Y><T><H><N><L><Y><Y><L><A><Q><V><Y><Q><H><L><E><M><F><E><K><A><A><H><Y><C><H><S><T><L><K><R><Q><L><E><H><N><A><Y><H><P><I><E><W><A><I><N><A><A><T><L><S><Q><F><Y><I><N><K><L><C><F><M><E><A><R><H><C><L><S><A><A><N><V><I><F><G><Q><T><G><K><I><S><A><T><E><D><T><P><E><A><E><G><E><V><P><E><L><Y><H><Q><R><K><G><E><I><A><R><C><W><I><K><Y><C><L><T><L><M><Q><N><A><Q><L><S><M><Q><D><N><I><G><E><L><D><L><D><K><Q><S><E><L><R><A><L><R><K><K><E><L><D><E><E><E><S><I><R><K><K><A><V><Q><F><G><T><G><E><L><C><D><A><I><S><A><V><E><E><K><V><S><Y><L><R><P><L><D><F><E><E><A><R><E><L><F><L><L><G><Q><H><Y><V><F><E><A><K><E><F><F><Q><I><D><G><Y><V><T><D><H><I><E><V><V><Q><D><H><S><A><L><F><K><V><L><A><F><F><E><T><D><M><E><R><R><C><K><M><H><K><R><R><I><A><M><L><E><P><L><T><V><D><L><N><P><Q><Y><Y><L><L><V><N><R><Q><I><Q><F><E><I><A><H><A><Y><Y><D><M><M><D><L><K><V><A><I><A><D><R><L><R><D><P><D><S><H><I><V><K><K><I><N><N><L><N><K><S><A><L><K><Y><Y><Q><L><F><L><D><S><L><R><D><P><N><K><V><F><P><E><H><I><G><E><D><V><L><R><P><A><M><L><A><K><F><R><V><A><R><L><Y><G><K><I><I><T><A><D><P><K><K><E><L><E><N><L><A><T><S><L><E><H><Y><K><F><I><V><D><Y><C><E><K><H><P><E><A><A><Q><E><I><E><V><E><L><E><L><S><K><E><M><V><S><L><L><P><T><K><M><E><R><F><R><T><K><M><A><L><T> | Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.<BOP> | Q96EK5 |
P17693 | HLAG_HUMAN | Soluble HLA class I histocompatibility antigen, alpha chain G | Homo | <M><V><V><M><A><P><R><T><L><F><L><L><L><S><G><A><L><T><L><T><E><T><W><A><G><S><H><S><M><R><Y><F><S><A><A><V><S><R><P><G><R><G><E><P><R><F><I><A><M><G><Y><V><D><D><T><Q><F><V><R><F><D><S><D><S><A><C><P><R><M><E><P><R><A><P><W><V><E><Q><E><G><P><E><Y><W><E><E><E><T><R><N><T><K><A><H><A><Q><T><D><R><M><N><L><Q><T><L><R><G><Y><Y><N><Q><S><E><A><S><S><H><T><L><Q><W><M><I><G><C><D><L><G><S><D><G><R><L><L><R><G><Y><E><Q><Y><A><Y><D><G><K><D><Y><L><A><L><N><E><D><L><R><S><W><T><A><A><D><T><A><A><Q><I><S><K><R><K><C><E><A><A><N><V><A><E><Q><R><R><A><Y><L><E><G><T><C><V><E><W><L><H><R><Y><L><E><N><G><K><E><M><L><Q><R><A><D><P><P><K><T><H><V><T><H><H><P><V><F><D><Y><E><A><T><L><R><C><W><A><L><G><F><Y><P><A><E><I><I><L><T><W><Q><R><D><G><E><D><Q><T><Q><D><V><E><L><V><E><T><R><P><A><G><D><G><T><F><Q><K><W><A><A><V><V><V><P><S><G><E><E><Q><R><Y><T><C><H><V><Q><H><E><G><L><P><E><P><L><M><L><R><W><K><Q><S><S><L><P><T><I><P><I><M><G><I><V><A><G><L><V><V><L><A><A><V><V><T><G><A><A><V><A><A><V><L><W><R><K><K><S><S><D> | Likely does not bind B2M and presents peptides.<BOP> | P17693 |
P01602 | KV105_HUMAN | Ig kappa chain V-I region Kue | Homo | <M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><P><G><A><K><C><D><I><Q><M><T><Q><S><P><S><T><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><S><I><S><S><W><L><A><W><Y><Q><Q><K><P><G><K><A><P><K><L><L><I><Y><K><A><S><S><L><E><S><G><V><P><S><R><F><S><G><S><G><S><G><T><E><F><T><L><T><I><S><S><L><Q><P><D><D><F><A><T><Y><Y><C><Q><Q><Y><N><S><Y><S> | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P01602 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.