accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1 value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q8WU39 | MZB1_HUMAN | Proapoptotic caspase adapter protein | Homo | <M><R><L><S><L><P><L><L><L><L><L><L><G><A><W><A><I><P><G><G><L><G><D><R><A><P><L><T><A><T><A><P><Q><L><D><D><E><E><M><Y><S><A><H><M><P><A><H><L><R><C><D><A><C><R><A><V><A><Y><Q><M><W><Q><N><L><A><K><A><E><T><K><L><H><T><S><N><S><G><G><R><R><E><L><S><E><L><V><Y><T><D><V><L><D><R><S><C><S><R><N><W><Q><D><Y><G><V><R><E><V><D><Q><V><K><R><L><T><G><P><G><L><S><E><G><P><E><P><S><I><S><V><M><V><T><G><G><P><W><P><T><R><L><S><R><T><C><L><H><Y><L><G><E><F><G><E><D><Q><I><Y><E><A><H><Q><Q><G><R><G><A><L><E><A><L><L><C><G><G><P><Q><G><A><C><S><E><K><V><S><A><T><R><E><E><L> | Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.<BOP> | Q8WU39 |
Q9HBK9 | AS3MT_HUMAN | S-adenosyl-L-methionine:arsenic(III) methyltransferase | Homo | <M><A><A><L><R><D><A><E><I><Q><K><D><V><Q><T><Y><Y><G><Q><V><L><K><R><S><A><D><L><Q><T><N><G><C><V><T><T><A><R><P><V><P><K><H><I><R><E><A><L><Q><N><V><H><E><E><V><A><L><R><Y><Y><G><C><G><L><V><I><P><E><H><L><E><N><C><W><I><L><D><L><G><S><G><S><G><R><D><C><Y><V><L><S><Q><L><V><G><E><K><G><H><V><T><G><I><D><M><T><K><G><Q><V><E><V><A><E><K><Y><L><D><Y><H><M><E><K><Y><G><F><Q><A><S><N><V><T><F><I><H><G><Y><I><E><K><L><G><E><A><G><I><K><N><E><S><H><D><I><V><V><S><N><C><V><I><N><L><V><P><D><K><Q><Q><V><L><Q><E><A><Y><R><V><L><K><H><G><G><E><L><Y><F><S><D><V><Y><T><S><L><E><L><P><E><E><I><R><T><H><K><V><L><W><G><E><C><L><G><G><A><L><Y><W><K><E><L><A><V><L><A><Q><K><I><G><F><C><P><P><R><L><V><T><A><N><L><I><T><I><Q><N><K><E><L><E><R><V><I><G><D><C><R><F><V><S><A><T><F><R><L><F><K><H><S><K><T><G><P><T><K><R><C><Q><V><I><Y><N><G><G><I><T><G><H><E><K><E><L><M><F><D><A><N><F><T><F><K><E><G><E><I><V><E><V><D><E><E><T><A><A><I><L><K><N><S><R><F><A><Q><D><F><L><I><R><P><I><G><E><K><L><P><T><S><G><G><C><S><A><L><E><L><K><D><I><I><T><D><P><F><K><L><A><E><E><S><D><S><M><K><S><R><C><V><P><D><A><A><G><G><C><C><G><T><K><K><S><C> | Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals . It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 . Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH .<BOP> | Q9HBK9 |
Q9H2A2 | AL8A1_HUMAN | Aldehyde dehydrogenase family 8 member A1 | Homo | <M><A><G><T><N><A><L><L><M><L><E><N><F><I><D><G><K><F><L><P><C><S><S><Y><I><D><S><Y><D><P><S><T><G><E><V><Y><C><R><V><P><N><S><G><K><D><E><I><E><A><A><V><K><A><A><R><E><A><F><P><S><W><S><S><R><S><P><Q><E><R><S><R><V><L><N><Q><V><A><D><L><L><E><Q><S><L><E><E><F><A><Q><A><E><S><K><D><Q><G><K><T><L><A><L><A><R><T><M><D><I><P><R><S><V><Q><N><F><R><F><F><A><S><S><S><L><H><H><T><S><E><C><T><Q><M><D><H><L><G><C><M><H><Y><T><V><R><A><P><V><G><V><A><G><L><I><S><P><W><N><L><P><L><Y><L><L><T><W><K><I><A><P><A><M><A><A><G><N><T><V><I><A><K><P><S><E><L><T><S><V><T><A><W><M><L><C><K><L><L><D><K><A><G><V><P><P><G><V><V><N><I><V><F><G><T><G><P><R><V><G><E><A><L><V><S><H><P><E><V><P><L><I><S><F><T><G><S><Q><P><T><A><E><R><I><T><Q><L><S><A><P><H><C><K><K><L><S><L><E><L><G><G><K><N><P><A><I><I><F><E><D><A><N><L><D><E><C><I><P><A><T><V><R><S><S><F><A><N><Q><G><E><I><C><L><C><T><S><R><I><F><V><Q><K><S><I><Y><S><E><F><L><K><R><F><V><E><A><T><R><K><W><K><V><G><I><P><S><D><P><L><V><S><I><G><A><L><I><S><K><A><H><L><E><K><V><R><S><Y><V><K><R><A><L><A><E><G><A><Q><I><W><C><G><E><G><V><D><K><L><S><L><P><A><R><N><Q><A><G><Y><F><M><L><P><T><V><I><T><D><I><K><D><E><S><C><C><M><T><E><E><I><F><G><P><V><T><C><V><V><P><F><D><S><E><E><E><V><I><E><R><A><N><N><V><K><Y><G><L><A><A><T><V><W><S><S><N><V><G><R><V><H><R><V><A><K><K><L><Q><S><G><L><V><W><T><N><C><W><L><I><R><E><L><N><L><P><F><G><G><M><K><S><S><G><I><G><R><E><G><A><K><D><S><Y><D><F><F><T><E><I><K><T><I><T><V><K><H> | Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.<BOP> | Q9H2A2 |
Q14154 | DELE1_HUMAN | DAP3-binding cell death enhancer 1 short form | Homo | <M><W><R><L><P><G><L><L><G><R><A><L><P><R><T><L><G><P><S><L><W><R><V><T><P><K><S><T><S><P><D><G><P><Q><T><T><S><S><T><L><L><V><P><V><P><N><L><D><R><S><G><P><H><G><P><G><T><S><G><G><P><R><S><H><G><W><K><D><A><F><Q><W><M><S><S><R><V><S><P><N><T><L><W><D><A><I><S><W><G><T><L><A><V><L><A><L><Q><L><A><R><Q><I><H><F><Q><A><S><L><P><A><G><P><Q><R><V><E><H><C><S><W><H><S><P><L><D><R><F><F><S><S><P><L><W><H><P><C><S><S><L><R><Q><H><I><L><P><S><P><D><G><P><A><P><R><H><T><G><L><R><E><P><R><L><G><Q><E><E><A><S><A><Q><P><R><N><F><S><H><N><S><L><R><G><A><R><P><Q><D><P><S><E><E><G><P><G><D><F><G><F><L><H><A><S><S><S><I><E><S><E><A><K><P><A><Q><P><Q><P><T><G><E><K><E><Q><D><K><S><K><T><L><S><L><E><E><A><V><T><S><I><Q><Q><L><F><Q><L><S><V><S><I><A><F><N><F><L><G><T><E><N><M><K><S><G><D><H><T><A><A><F><S><Y><F><Q><K><A><A><A><R><G><Y><S><K><A><Q><Y><N><A><G><L><C><H><E><H><G><R><G><T><P><R><D><I><S><K><A><V><L><Y><Y><Q><L><A><A><S><Q><G><H><S><L><A><Q><Y><R><Y><A><R><C><L><L><R><D><P><A><S><S><W><N><P><E><R><Q><R><A><V><S><L><L><K><Q><A><A><D><S><G><L><R><E><A><Q><A><F><L><G><V><L><F><T><K><E><P><Y><L><D><E><Q><R><A><V><K><Y><L><W><L><A><A><N><N><G><D><S><Q><S><R><Y><H><L><G><I><C><Y><E><K><G><L><G><V><Q><R><N><L><G><E><A><L><R><C><Y><Q><Q><S><A><A><L><G><N><E><A><A><Q><E><R><L><R><A><L><F><S><M><G><A><A><A><P><G><P><S><D><L><T><V><T><G><L><K><S><F><S><S><P><S><L><C><S><L><N><T><L><L><A><G><T><S><R><L><P><H><A><S><S><T><G><N><L><G><L><L><C><R><S><G><H><L><G><A><S><L><E><A><S><S><R><A><I><P><P><H><P><Y><P><L><E><R><S><V><V><R><L><G><F><G> | Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI . It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR .<BOP> | Q14154 |
Q7Z569 | BRAP_HUMAN | Renal carcinoma antigen NY-REN-63 | Homo | <M><S><V><S><L><V><V><I><R><L><E><L><A><E><H><S><P><V><P><A><G><F><G><F><S><A><A><A><G><E><M><S><D><E><E><I><K><K><T><T><L><A><S><A><V><A><C><L><E><G><K><S><P><G><E><K><V><A><I><I><H><Q><H><L><G><R><R><E><M><T><D><V><I><I><E><T><M><K><S><N><P><D><E><L><K><T><T><V><E><E><R><K><S><S><E><A><S><P><T><A><Q><R><S><K><D><H><S><K><E><C><I><N><A><A><P><D><S><P><S><K><Q><L><P><D><Q><I><S><F><F><S><G><N><P><S><V><E><I><V><H><G><I><M><H><L><Y><K><T><N><K><M><T><S><L><K><E><D><V><R><R><S><A><M><L><C><I><L><T><V><P><A><A><M><T><S><H><D><L><M><K><F><V><A><P><F><N><E><V><I><E><Q><M><K><I><I><R><D><S><T><P><N><Q><Y><M><V><L><I><K><F><R><A><Q><A><D><A><D><S><F><Y><M><T><C><N><G><R><Q><F><N><S><I><E><D><D><V><C><Q><L><V><Y><V><E><R><A><E><V><L><K><S><E><D><G><A><S><L><P><V><M><D><L><T><E><L><P><K><C><T><V><C><L><E><R><M><D><E><S><V><N><G><I><L><T><T><L><C><N><H><S><F><H><S><Q><C><L><Q><R><W><D><D><T><T><C><P><V><C><R><Y><C><Q><T><P><E><P><V><E><E><N><K><C><F><E><C><G><V><Q><E><N><L><W><I><C><L><I><C><G><H><I><G><C><G><R><Y><V><S><R><H><A><Y><K><H><F><E><E><T><Q><H><T><Y><A><M><Q><L><T><N><H><R><V><W><D><Y><A><G><D><N><Y><V><H><R><L><V><A><S><K><T><D><G><K><I><V><Q><Y><E><C><E><G><D><T><C><Q><E><E><K><I><D><A><L><Q><L><E><Y><S><Y><L><L><T><S><Q><L><E><S><Q><R><I><Y><W><E><N><K><I><V><R><I><E><K><D><T><A><E><E><I><N><N><M><K><T><K><F><K><E><T><I><E><K><C><D><N><L><E><H><K><L><N><D><L><L><K><E><K><Q><S><V><E><R><K><C><T><Q><L><N><T><K><V><A><K><L><T><N><E><L><K><E><E><Q><E><M><N><K><C><L><R><A><N><Q><V><L><L><Q><N><K><L><K><E><E><E><R><V><L><K><E><T><C><D><Q><K><D><L><Q><I><T><E><I><Q><E><Q><L><R><D><V><M><F><Y><L><E><T><Q><Q><K><I><N><H><L><P><A><E><T><R><Q><E><I><Q><E><G><Q><I><N><I><A><M><A><S><A><S><S><P><A><S><S><G><G><S><G><K><L><P><S><R><K><G><R><S><K><R><G><K> | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.<BOP> | Q7Z569 |
Q9P003 | CNIH4_HUMAN | Cornichon family AMPA receptor auxiliary protein 4 | Homo | <M><E><A><V><V><F><V><F><S><L><L><D><C><C><A><L><I><F><L><S><V><Y><F><I><I><T><L><S><D><L><E><C><D><Y><I><N><A><R><S><C><C><S><K><L><N><K><W><V><I><P><E><L><I><G><H><T><I><V><T><V><L><L><L><M><S><L><H><W><F><I><F><L><L><N><L><P><V><A><T><W><N><I><Y><R><Y><I><M><V><P><S><G><N><M><G><V><F><D><P><T><E><I><H><N><R><G><Q><L><K><S><H><M><K><E><A><M><I><K><L><G><F><H><L><L><C><F><F><M><Y><L><Y><S><M><I><L><A><L><I><N><D> | Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery .<BOP> | Q9P003 |
A8MWD9 | RUXGL_HUMAN | Putative small nuclear ribonucleoprotein G-like protein 15 | Homo | <M><S><K><A><H><P><P><E><L><K><K><F><T><D><K><K><F><S><L><K><L><N><G><G><R><H><V><Q><G><I><L><R><G><F><D><P><F><M><N><L><V><I><D><E><C><V><E><M><A><T><S><G><Q><Q><K><N><I><G><M><V><E><I><R><G><N><S><I><I><M><L><E><A><L><E><R><V> | Associated with snRNP U1, U2, U4/U6 and U5.<BOP> | A8MWD9 |
P20774 | MIME_HUMAN | Osteoinductive factor | Homo | <M><K><T><L><Q><S><T><L><L><L><L><L><L><V><P><L><I><K><P><A><P><P><T><Q><Q><D><S><R><I><I><Y><D><Y><G><T><D><N><F><E><E><S><I><F><S><Q><D><Y><E><D><K><Y><L><D><G><K><N><I><K><E><K><E><T><V><I><I><P><N><E><K><S><L><Q><L><Q><K><D><E><A><I><T><P><L><P><P><K><K><E><N><D><E><M><P><T><C><L><L><C><V><C><L><S><G><S><V><Y><C><E><E><V><D><I><D><A><V><P><P><L><P><K><E><S><A><Y><L><Y><A><R><F><N><K><I><K><K><L><T><A><K><D><F><A><D><I><P><N><L><R><R><L><D><F><T><G><N><L><I><E><D><I><E><D><G><T><F><S><K><L><S><L><L><E><E><L><S><L><A><E><N><Q><L><L><K><L><P><V><L><P><P><K><L><T><L><F><N><A><K><Y><N><K><I><K><S><R><G><I><K><A><N><A><F><K><K><L><N><N><L><T><F><L><Y><L><D><H><N><A><L><E><S><V><P><L><N><L><P><E><S><L><R><V><I><H><L><Q><F><N><N><I><A><S><I><T><D><D><T><F><C><K><A><N><D><T><S><Y><I><R><D><R><I><E><E><I><R><L><E><G><N><P><I><V><L><G><K><H><P><N><S><F><I><C><L><K><R><L><P><I><G><S><Y><F> | Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.<BOP> | P20774 |
Q9H3Y6 | SRMS_HUMAN | Tyrosine-protein kinase Srms | Homo | <M><E><P><F><L><R><R><R><L><A><F><L><S><F><F><W><D><K><I><W><P><A><G><G><E><P><D><H><G><T><P><G><S><L><D><P><N><T><D><P><V><P><T><L><P><A><E><P><C><S><P><F><P><Q><L><F><L><A><L><Y><D><F><T><A><R><C><G><G><E><L><S><V><R><R><G><D><R><L><C><A><L><E><E><G><G><G><Y><I><F><A><R><R><L><S><G><Q><P><S><A><G><L><V><P><I><T><H><V><A><K><A><S><P><E><T><L><S><D><Q><P><W><Y><F><S><G><V><S><R><T><Q><A><Q><Q><L><L><L><S><P><P><N><E><P><G><A><F><L><I><R><P><S><E><S><S><L><G><G><Y><S><L><S><V><R><A><Q><A><K><V><C><H><Y><R><V><S><M><A><A><D><G><S><L><Y><L><Q><K><G><R><L><F><P><G><L><E><E><L><L><T><Y><Y><K><A><N><W><K><L><I><Q><N><P><L><L><Q><P><C><M><P><Q><K><A><P><R><Q><D><V><W><E><R><P><H><S><E><F><A><L><G><R><K><L><G><E><G><Y><F><G><E><V><W><E><G><L><W><L><G><S><L><P><V><A><I><K><V><I><K><S><A><N><M><K><L><T><D><L><A><K><E><I><Q><T><L><K><G><L><R><H><E><R><L><I><R><L><H><A><V><C><S><G><G><E><P><V><Y><I><V><T><E><L><M><R><K><G><N><L><Q><A><F><L><G><T><P><E><G><R><A><L><R><L><P><P><L><L><G><F><A><C><Q><V><A><E><G><M><S><Y><L><E><E><Q><R><V><V><H><R><D><L><A><A><R><N><V><L><V><D><D><G><L><A><C><K><V><A><D><F><G><L><A><R><L><L><K><D><D><I><Y><S><P><S><S><S><S><K><I><P><V><K><W><T><A><P><E><A><A><N><Y><R><V><F><S><Q><K><S><D><V><W><S><F><G><V><L><L><H><E><V><F><T><Y><G><Q><C><P><Y><E><G><M><T><N><H><E><T><L><Q><Q><I><M><R><G><Y><R><L><P><R><P><A><A><C><P><A><E><V><Y><V><L><M><L><E><C><W><R><S><S><P><E><E><R><P><S><F><A><T><L><R><E><K><L><H><A><I><H><R><C><H><P> | Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues . Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues . Phosphorylation of KHDRBS1 is EGF-dependent .<BOP> | Q9H3Y6 |
O94763 | RMP_HUMAN | RNA polymerase II subunit 5-mediating protein | Homo | <M><E><A><P><T><V><E><T><P><P><D><P><S><P><P><S><A><P><A><P><A><L><V><P><L><R><A><P><D><V><A><R><L><R><E><E><Q><E><K><V><V><T><N><C><Q><E><R><I><Q><H><W><K><K><V><D><N><D><Y><N><A><L><R><E><R><L><S><T><L><P><D><K><L><S><Y><N><I><M><V><P><F><G><P><F><A><F><M><P><G><K><L><V><H><T><N><E><V><T><V><L><L><G><D><N><W><F><A><K><C><S><A><K><Q><A><V><G><L><V><E><H><R><K><E><H><V><R><K><T><I><D><D><L><K><K><V><M><K><N><F><E><S><R><V><E><F><T><E><D><L><Q><K><M><S><D><A><A><G><D><I><V><D><I><R><E><E><I><K><C><D><F><E><F><K><A><K><H><R><I><A><H><K><P><H><S><K><P><K><T><S><D><I><F><E><A><D><I><A><N><D><V><K><S><K><D><L><L><A><D><K><E><L><W><A><R><L><E><E><L><E><R><Q><E><E><L><L><G><E><L><D><S><K><P><D><T><V><I><A><N><G><E><D><T><T><S><S><E><E><E><K><E><D><R><N><T><N><V><N><A><M><H><Q><V><T><D><S><H><T><P><C><H><K><D><V><A><S><S><E><P><F><S><G><Q><V><N><S><Q><L><N><C><S><V><N><G><S><S><S><Y><H><S><D><D><D><D><D><D><D><D><D><D><D><D><D><N><I><D><D><D><D><G><D><N><D><H><E><A><L><G><V><G><D><N><S><I><P><T><I><Y><F><S><H><T><V><E><P><K><R><V><R><I><N><T><G><K><N><T><T><L><K><F><S><E><K><K><E><E><A><K><R><K><R><K><N><S><T><G><S><G><H><S><A><Q><E><L><P><T><I><R><T><P><A><D><I><Y><R><A><F><V><D><V><V><N><G><E><Y><V><P><R><K><S><I><L><K><S><R><S><R><E><N><S><V><C><S><D><T><S><E><S><S><A><A><E><F><D><D><R><R><G><V><L><R><S><I><S><C><E><E><A><T><C><S><D><T><S><E><S><I><L><E><E><E><P><Q><E><N><Q><K><K><L><L><P><L><S><V><T><P><E><A><F><S><G><T><V><I><E><K><E><F><V><S><P><S><L><T><P><P><P><A><I><A><H><P><A><L><P><T><I><P><E><R><K><E><V><L><L><E><A><S><E><E><T><G><K><R><V><S><K><F><K><A><A><R><L><Q><Q><K><D> | Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.<BOP> | O94763 |
Q9NRS6 | SNX15_HUMAN | Sorting nexin-15 | Homo | <M><S><R><Q><A><K><D><D><F><L><R><H><Y><T><V><S><D><P><R><T><H><P><K><G><Y><T><E><Y><K><V><T><A><Q><F><I><S><K><K><D><P><E><D><V><K><E><V><V><V><W><K><R><Y><S><D><F><R><K><L><H><G><D><L><A><Y><T><H><R><N><L><F><R><R><L><E><E><F><P><A><F><P><R><A><Q><V><F><G><R><F><E><A><S><V><I><E><E><R><R><K><G><A><E><D><L><L><R><F><T><V><H><I><P><A><L><N><N><S><P><Q><L><K><E><F><F><R><G><G><E><V><T><R><P><L><E><V><S><R><D><L><H><I><L><P><P><P><L><I><P><T><P><P><P><D><D><P><R><L><S><Q><L><L><P><A><E><R><R><G><L><E><E><L><E><V><P><V><D><P><P><P><S><S><P><A><Q><E><A><L><D><L><L><F><N><C><E><S><T><E><E><A><S><G><S><P><A><R><G><P><L><T><E><A><E><L><A><L><F><D><P><F><S><K><E><E><G><A><A><P><S><P><T><H><V><A><E><L><A><T><M><E><V><E><S><A><R><L><D><Q><E><P><W><E><P><G><G><Q><E><E><E><E><D><G><E><G><G><P><T><P><A><Y><L><S><Q><A><T><E><L><I><T><Q><A><L><R><D><E><K><A><G><A><Y><A><A><A><L><Q><G><Y><R><D><G><V><H><V><L><L><Q><G><V><P><S><D><P><L><P><A><R><Q><E><G><V><K><K><K><A><A><E><Y><L><K><R><A><E><E><I><L><R><L><H><L><S><Q><L><P><P> | May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.<BOP> | Q9NRS6 |
B4DU55 | ZN879_HUMAN | Zinc finger protein 879 | Homo | <M><A><R><R><L><L><P><A><H><V><Q><E><S><V><T><F><R><D><V><A><V><F><F><S><Q><D><E><W><L><H><L><D><S><A><Q><R><A><L><Y><R><E><V><M><L><E><N><Y><S><I><L><V><S><L><G><I><L><F><S><K><P><K><V><I><S><Q><L><E><Q><G><E><D><P><W><M><V><E><S><G><V><P><Q><G><A><H><L><G><W><E><S><L><F><G><T><I><V><S><K><E><E><N><Q><E><V><M><K><K><L><I><I><D><G><T><F><D><F><K><L><E><K><T><Y><I><N><E><D><K><L><E><K><Q><Q><G><K><K><N><R><L><F><S><K><V><L><V><T><I><K><K><V><Y><M><K><E><R><S><F><K><G><V><E><F><G><K><N><L><G><L><K><S><S><L><I><R><K><P><R><I><V><S><R><G><R><R><P><R><S><Q><Q><Y><S><V><L><F><K><Q><L><G><V><N><T><V><R><K><C><Y><K><C><N><I><C><G><K><I><F><L><H><S><S><S><L><S><K><H><Q><R><I><H><T><G><E><K><L><Y><K><C><K><E><C><R><K><A><F><S><Q><S><S><S><L><T><Q><H><L><R><V><H><T><G><E><K><P><Y><I><C><S><E><C><G><K><A><F><S><F><T><T><S><L><I><G><H><Q><R><M><H><T><G><E><R><P><Y><K><C><K><E><C><G><K><T><F><K><G><S><S><S><L><N><N><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><R><A><F><S><Q><C><S><S><L><I><Q><H><H><R><I><H><T><G><E><K><P><Y><E><C><T><Q><C><G><K><A><F><T><S><I><S><R><L><S><R><H><H><R><I><H><T><G><E><K><P><F><H><C><N><E><C><G><K><V><F><S><Y><H><S><A><L><I><I><H><Q><R><I><H><T><G><E><K><P><Y><A><C><K><E><C><G><K><A><F><S><Q><S><S><A><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><W><I><S><R><L><N><I><H><H><R><I><H><T><G><E><K><P><Y><N><C><K><E><C><G><K><A><F><S><S><H><S><G><V><N><T><H><R><K><I><H><T><G><E><K><P><Y><K><C><N><D><C><E><K><A><F><N><Q><S><S><A><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><N><C><K><V><C><G><K><A><F><R><Q><S><S><S><L><M><T><H><M><R><I><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><A><F><S><Q><S><S><S><L><T><N><H><Q><R><T><H><N> | May be involved in transcriptional regulation.<BOP> | B4DU55 |
Q9H0P0 | 5NT3A_HUMAN | p36 | Homo | <M><R><A><P><S><M><D><R><A><A><V><A><R><V><G><A><V><A><S><A><S><V><C><A><L><V><A><G><V><V><L><A><Q><Y><I><F><T><L><K><R><K><T><G><R><K><T><K><I><I><E><M><M><P><E><F><Q><K><S><S><V><R><I><K><N><P><T><R><V><E><E><I><I><C><G><L><I><K><G><G><A><A><K><L><Q><I><I><T><D><F><D><M><T><L><S><R><F><S><Y><K><G><K><R><C><P><T><C><H><N><I><I><D><N><C><K><L><V><T><D><E><C><R><K><K><L><L><Q><L><K><E><K><Y><Y><A><I><E><V><D><P><V><L><T><V><E><E><K><Y><P><Y><M><V><E><W><Y><T><K><S><H><G><L><L><V><Q><Q><A><L><P><K><A><K><L><K><E><I><V><A><E><S><D><V><M><L><K><E><G><Y><E><N><F><F><D><K><L><Q><Q><H><S><I><P><V><F><I><F><S><A><G><I><G><D><V><L><E><E><V><I><R><Q><A><G><V><Y><H><P><N><V><K><V><V><S><N><F><M><D><F><D><E><T><G><V><L><K><G><F><K><G><E><L><I><H><V><F><N><K><H><D><G><A><L><R><N><T><E><Y><F><N><Q><L><K><D><N><S><N><I><I><L><L><G><D><S><Q><G><D><L><R><M><A><D><G><V><A><N><V><E><H><I><L><K><I><G><Y><L><N><D><R><V><D><E><L><L><E><K><Y><M><D><S><Y><D><I><V><L><V><Q><D><E><S><L><E><V><A><N><S><I><L><Q><K><I><L> | Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) . CMP seems to be the preferred substrate .<BOP> | Q9H0P0 |
P28799 | GRN_HUMAN | Granulin E | Homo | <M><W><T><L><V><S><W><V><A><L><T><A><G><L><V><A><G><T><R><C><P><D><G><Q><F><C><P><V><A><C><C><L><D><P><G><G><A><S><Y><S><C><C><R><P><L><L><D><K><W><P><T><T><L><S><R><H><L><G><G><P><C><Q><V><D><A><H><C><S><A><G><H><S><C><I><F><T><V><S><G><T><S><S><C><C><P><F><P><E><A><V><A><C><G><D><G><H><H><C><C><P><R><G><F><H><C><S><A><D><G><R><S><C><F><Q><R><S><G><N><N><S><V><G><A><I><Q><C><P><D><S><Q><F><E><C><P><D><F><S><T><C><C><V><M><V><D><G><S><W><G><C><C><P><M><P><Q><A><S><C><C><E><D><R><V><H><C><C><P><H><G><A><F><C><D><L><V><H><T><R><C><I><T><P><T><G><T><H><P><L><A><K><K><L><P><A><Q><R><T><N><R><A><V><A><L><S><S><S><V><M><C><P><D><A><R><S><R><C><P><D><G><S><T><C><C><E><L><P><S><G><K><Y><G><C><C><P><M><P><N><A><T><C><C><S><D><H><L><H><C><C><P><Q><D><T><V><C><D><L><I><Q><S><K><C><L><S><K><E><N><A><T><T><D><L><L><T><K><L><P><A><H><T><V><G><D><V><K><C><D><M><E><V><S><C><P><D><G><Y><T><C><C><R><L><Q><S><G><A><W><G><C><C><P><F><T><Q><A><V><C><C><E><D><H><I><H><C><C><P><A><G><F><T><C><D><T><Q><K><G><T><C><E><Q><G><P><H><Q><V><P><W><M><E><K><A><P><A><H><L><S><L><P><D><P><Q><A><L><K><R><D><V><P><C><D><N><V><S><S><C><P><S><S><D><T><C><C><Q><L><T><S><G><E><W><G><C><C><P><I><P><E><A><V><C><C><S><D><H><Q><H><C><C><P><Q><G><Y><T><C><V><A><E><G><Q><C><Q><R><G><S><E><I><V><A><G><L><E><K><M><P><A><R><R><A><S><L><S><H><P><R><D><I><G><C><D><Q><H><T><S><C><P><V><G><Q><T><C><C><P><S><L><G><G><S><W><A><C><C><Q><L><P><H><A><V><C><C><E><D><R><Q><H><C><C><P><A><G><Y><T><C><N><V><K><A><R><S><C><E><K><E><V><V><S><A><Q><P><A><T><F><L><A><R><S><P><H><V><G><V><K><D><V><E><C><G><E><G><H><F><C><H><D><N><Q><T><C><C><R><D><N><R><Q><G><W><A><C><C><P><Y><R><Q><G><V><C><C><A><D><R><R><H><C><C><P><A><G><F><R><C><A><A><R><G><T><K><C><L><R><R><E><A><P><R><W><D><A><P><L><R><D><P><A><L><R><Q><L><L> | Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.<BOP> | P28799 |
A6NI73 | LIRA5_HUMAN | Leukocyte immunoglobulin-like receptor 9 | Homo | <M><A><P><W><S><H><P><S><A><Q><L><Q><P><V><G><G><D><A><V><S><P><A><L><M><V><L><L><C><L><G><L><S><L><G><P><R><T><H><V><Q><A><G><N><L><S><K><A><T><L><W><A><E><P><G><S><V><I><S><R><G><N><S><V><T><I><R><C><Q><G><T><L><E><A><Q><E><Y><R><L><V><K><E><G><S><P><E><P><W><D><T><Q><N><P><L><E><P><K><N><K><A><R><F><S><I><P><S><M><T><E><H><H><A><G><R><Y><R><C><Y><Y><Y><S><P><A><G><W><S><E><P><S><D><P><L><E><L><V><V><T><G><F><Y><N><K><P><T><L><S><A><L><P><S><P><V><V><T><S><G><E><N><V><T><L><Q><C><G><S><R><L><R><F><D><R><F><I><L><T><E><E><G><D><H><K><L><S><W><T><L><D><S><Q><L><T><P><S><G><Q><F><Q><A><L><F><P><V><G><P><V><T><P><S><H><R><W><M><L><R><C><Y><G><S><R><R><H><I><L><Q><V><W><S><E><P><S><D><L><L><E><I><P><V><S><G><A><A><D><N><L><S><P><S><Q><N><K><S><D><S><G><T><A><S><H><L><Q><D><Y><A><V><E><N><L><I><R><M><G><M><A><G><L><I><L><V><V><L><G><I><L><I><F><Q><D><W><H><S><Q><R><S><P><Q><A><A><A><G><R> | May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.<BOP> | A6NI73 |
A0A578 | TVB51_HUMAN | T cell receptor beta variable 5-1 | Homo | <M><G><S><R><L><L><C><W><V><L><L><C><L><L><G><A><G><P><V><K><A><G><V><T><Q><T><P><R><Y><L><I><K><T><R><G><Q><Q><V><T><L><S><C><S><P><I><S><G><H><R><S><V><S><W><Y><Q><Q><T><P><G><Q><G><L><Q><F><L><F><E><Y><F><S><E><T><Q><R><N><K><G><N><F><P><G><R><F><S><G><R><Q><F><S><N><S><R><S><E><M><N><V><S><T><L><E><L><G><D><S><A><L><Y><L><C><A><S><S><L> | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement | A0A578 |
Q96SZ6 | CK5P1_HUMAN | mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase | Homo | <M><H><P><L><Q><C><V><L><Q><V><Q><R><S><L><G><W><G><P><L><A><S><V><S><W><L><S><L><R><M><C><R><A><H><S><S><L><S><S><T><M><C><P><S><P><E><R><Q><E><D><G><A><R><K><D><F><S><S><R><L><A><A><G><P><T><F><Q><H><F><L><K><S><A><S><A><P><Q><E><K><L><S><S><E><V><E><D><P><P><P><Y><L><M><M><D><E><L><L><G><R><Q><R><K><V><Y><L><E><T><Y><G><C><Q><M><N><V><N><D><T><E><I><A><W><S><I><L><Q><K><S><G><Y><L><R><T><S><N><L><Q><E><A><D><V><I><L><L><V><T><C><S><I><R><E><K><A><E><Q><T><I><W><N><R><L><H><Q><L><K><A><L><K><T><R><R><P><R><S><R><V><P><L><R><I><G><I><L><G><C><M><A><E><R><L><K><E><E><I><L><N><R><E><K><M><V><D><I><L><A><G><P><D><A><Y><R><D><L><P><R><L><L><A><V><A><E><S><G><Q><Q><A><A><N><V><L><L><S><L><D><E><T><Y><A><D><V><M><P><V><Q><T><S><A><S><A><T><S><A><F><V><S><I><M><R><G><C><D><N><M><C><S><Y><C><I><V><P><F><T><R><G><R><E><R><S><R><P><I><A><S><I><L><E><E><V><K><K><L><S><E><Q><V><F><L><P><P><R><P><P><K><V><L><G><L><Q><G><L><K><E><V><T><L><L><G><Q><N><V><N><S><F><R><D><N><S><E><V><Q><F><N><S><A><V><P><T><N><L><S><R><G><F><T><T><N><Y><K><T><K><Q><G><G><L><R><F><A><H><L><L><D><Q><V><S><R><V><D><P><E><M><R><I><R><F><T><S><P><H><P><K><D><F><P><D><E><V><L><Q><L><I><H><E><R><D><N><I><C><K><Q><I><H><L><P><A><Q><S><G><S><S><R><V><L><E><A><M><R><R><G><Y><S><R><E><A><Y><V><E><L><V><H><H><I><R><E><S><I><P><G><V><S><L><S><S><D><F><I><A><G><F><C><G><E><T><E><E><D><H><V><Q><T><V><S><L><L><R><E><V><Q><Y><N><M><G><F><L><F><A><Y><S><M><R><Q><K><T><R><A><Y><H><R><L><K><D><D><V><P><E><E><V><K><L><R><R><L><E><E><L><I><T><I><F><R><E><E><A><T><K><A><N><Q><T><S><V><G><C><T><Q><L><V><L><V><E><G><L><S><K><R><S><A><T><D><L><C><G><R><N><D><G><N><L><K><V><I><F><P><D><A><E><M><E><D><V><N><N><P><G><L><R><V><R><A><Q><P><G><D><Y><V><L><V><K><I><T><S><A><S><S><Q><T><L><R><G><H><V><L><C><R><T><T><L><R><D><S><S><A><Y><C> | Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) . Essential for efficient and highly accurate protein translation by the ribosome . Specifically inhibits CDK5 activation by CDK5R1 . Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease .<BOP> | Q96SZ6 |
Q5JQS5 | OR2BB_HUMAN | Olfactory receptor 2B11 | Homo | <M><K><S><D><N><H><S><F><L><G><D><S><P><K><A><F><I><L><L><G><V><S><D><R><P><W><L><E><L><P><L><F><V><V><L><L><L><S><Y><V><L><A><M><L><G><N><V><A><I><I><L><A><S><R><V><D><P><Q><L><H><S><P><M><Y><I><F><L><S><H><L><S><F><L><D><L><C><Y><T><T><T><T><V><P><Q><M><L><V><N><M><G><S><S><Q><K><T><I><S><Y><G><G><C><T><V><Q><Y><A><V><F><H><W><L><G><C><T><E><C><I><V><L><A><A><M><A><L><D><R><Y><V><A><I><C><K><P><L><H><Y><A><V><L><M><H><R><A><L><C><Q><Q><L><V><A><L><A><W><L><S><G><F><G><N><S><F><V><Q><V><V><L><T><V><Q><L><P><F><C><G><R><Q><V><L><N><N><F><F><C><E><V><P><A><V><I><K><L><S><C><A><D><T><A><V><N><D><T><I><L><A><V><L><V><A><F><F><V><L><V><P><L><A><L><I><L><L><S><Y><G><F><I><A><R><A><V><L><R><I><Q><S><S><K><G><R><H><K><A><F><G><T><C><S><S><H><L><M><I><V><S><L><F><Y><L><P><A><I><Y><M><Y><L><Q><P><P><S><S><Y><S><Q><E><Q><G><K><F><I><S><L><F><Y><S><I><I><T><P><T><L><N><P><F><T><Y><T><L><R><N><K><D><M><K><G><A><L><R><R><L><L><A><R><I><W><R><L><C><G> | Odorant receptor.<BOP> | Q5JQS5 |
Q9H313 | TTYH1_HUMAN | Protein tweety homolog 1 | Homo | <M><G><A><P><P><G><Y><R><P><S><A><W><V><H><L><L><H><Q><L><P><R><A><D><F><Q><L><R><P><V><P><S><V><F><A><P><Q><E><Q><E><Y><Q><Q><A><L><L><L><V><A><A><L><A><G><L><G><L><G><L><S><L><I><F><I><A><V><Y><L><I><R><F><C><C><C><R><P><P><E><P><P><G><S><K><I><P><S><P><G><G><G><C><V><T><W><S><C><I><V><A><L><L><A><G><C><T><G><I><G><I><G><F><Y><G><N><S><E><T><S><D><G><V><S><Q><L><S><S><A><L><L><H><A><N><H><T><L><S><T><I><D><H><L><V><L><E><T><V><E><R><L><G><E><A><V><R><T><E><L><T><T><L><E><E><V><L><E><P><R><T><E><L><V><A><A><A><R><G><A><R><R><Q><A><E><A><A><A><Q><Q><L><Q><G><L><A><F><W><Q><G><V><P><L><S><P><L><Q><V><A><E><N><V><S><F><V><E><E><Y><R><W><L><A><Y><V><L><L><L><L><L><E><L><L><V><C><L><F><T><L><L><G><L><A><K><Q><S><K><W><L><V><I><V><M><T><V><M><S><L><L><V><L><V><L><S><W><G><S><M><G><L><E><A><A><T><A><V><G><L><S><D><F><C><S><N><P><D><P><Y><V><L><N><L><T><Q><E><E><T><G><L><S><S><D><I><L><S><Y><Y><L><L><C><N><R><A><V><S><N><P><F><Q><Q><R><L><T><L><S><Q><R><A><L><A><N><I><H><S><Q><L><L><G><L><E><R><E><A><V><P><Q><F><P><S><A><Q><K><P><L><L><S><L><E><E><T><L><N><V><T><E><G><N><F><H><Q><L><V><A><L><L><H><C><R><S><L><H><K><D><Y><G><A><A><L><R><G><L><C><E><D><A><L><E><G><L><L><F><L><L><L><F><S><L><L><S><A><G><A><L><A><T><A><L><C><S><L><P><R><A><W><A><L><F><P><P><S><D><D><Y><D><D><T><D><D><D><D><P><F><N><P><Q><E><S><K><R><F><V><Q><W><Q><S><S><I> | Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.<BOP> | Q9H313 |
Q6ZN32 | ETV3L_HUMAN | ETS translocation variant 3-like protein | Homo | <M><H><C><S><C><L><A><E><G><I><P><A><N><P><G><N><W><I><S><G><L><A><F><P><D><W><A><Y><K><A><E><S><S><P><G><S><R><Q><I><Q><L><W><H><F><I><L><E><L><L><Q><K><E><E><F><R><H><V><I><A><W><Q><Q><G><E><Y><G><E><F><V><I><K><D><P><D><E><V><A><R><L><W><G><R><R><K><C><K><P><Q><M><N><Y><D><K><L><S><R><A><L><R><Y><Y><Y><N><K><R><I><L><H><K><T><K><G><K><R><F><T><Y><K><F><N><F><S><K><L><I><V><V><N><Y><P><L><W><E><V><R><A><P><P><S><P><H><L><L><L><G><A><P><A><L><C><R><P><A><L><V><P><V><G><V><Q><S><E><L><L><H><S><M><L><F><A><H><Q><A><M><V><E><Q><L><T><G><Q><Q><T><P><R><G><P><P><E><T><S><G><D><K><K><G><S><S><S><S><V><Y><R><L><G><S><A><P><G><P><C><R><L><G><L><C><C><H><L><G><S><V><Q><G><E><L><P><G><V><A><S><F><T><P><P><L><P><P><P><L><P><S><N><W><T><C><L><S><G><P><F><L><P><P><L><P><S><E><Q><Q><L><P><G><A><F><K><P><D><I><L><L><P><G><P><R><S><L><P><G><A><W><H><F><P><G><L><P><L><L><A><G><L><G><Q><G><A><G><E><R><L><W><L><L><S><L><R><P><E><G><L><E><V><K><P><A><P><M><M><E><A><K><G><G><L><D><P><R><E><V><F><C><P><E><T><R><R><L><K><T><G><E><E><S><L><T><S><P><N><L><E><N><L><K><A><V><W><P><L><D><P><P> | Transcriptional regulator.<BOP> | Q6ZN32 |
Q8NG75 | OR5T1_HUMAN | Olfactory receptor OR11-179 | Homo | <M><S><G><L><P><S><D><M><D><L><Y><K><L><Q><L><N><N><F><T><E><V><T><M><F><I><L><I><S><F><T><E><E><F><D><V><Q><V><F><L><F><L><L><F><L><A><I><Y><L><F><T><L><I><G><N><L><G><L><V><V><P><I><I><G><D><F><W><L><H><S><P><M><Y><Y><F><L><G><V><L><S><F><L><D><V><C><Y><S><T><V><V><T><P><K><M><L><V><N><F><L><A><K><N><K><S><I><S><F><L><G><C><A><T><Q><M><F><L><A><C><T><F><G><T><T><E><C><F><L><L><A><A><M><A><Y><D><R><Y><V><A><I><Y><N><P><L><L><Y><S><V><S><M><S><P><R><V><Y><V><P><L><I><T><A><S><Y><V><A><S><I><L><H><A><T><I><H><T><V><A><T><F><S><L><S><F><C><G><S><N><E><I><R><H><V><F><C><N><M><P><P><L><L><A><I><S><C><S><D><T><H><V><I><Q><L><L><F><F><Y><F><V><G><S><I><E><I><V><T><I><L><I><V><L><I><S><Y><G><F><I><L><L><A><I><L><K><M><Q><S><A><E><G><R><R><K><V><F><S><T><C><G><A><H><L><T><G><V><T><I><Y><H><G><T><I><L><F><M><Y><V><R><P><S><S><S><Y><T><S><D><N><D><M><I><V><S><I><F><Y><T><I><V><I><P><M><L><N><P><I><I><Y><S><L><R><N><K><D><V><K><E><A><I><K><R><L><L><V><R><N><W><F><I><N><K><L> | Odorant receptor.<BOP> | Q8NG75 |
Q5VYS4 | MEDAG_HUMAN | Mesenteric estrogen-dependent adipose 4 | Homo | <M><A><G><A><A><C><E><P><V><A><R><P><S><L><T><S><I><S><S><G><E><L><R><S><L><W><T><C><D><C><E><L><A><L><L><P><L><A><Q><L><L><R><L><Q><P><G><A><F><Q><L><S><G><D><Q><L><V><V><A><R><P><G><E><P><A><A><A><R><G><G><F><N><V><F><G><D><G><L><V><R><L><D><G><Q><L><Y><R><L><S><S><Y><I><K><R><Y><V><E><L><T><N><Y><C><D><Y><K><D><Y><R><E><T><I><L><S><K><P><M><L><F><F><I><N><V><Q><T><K><K><D><T><S><K><E><R><T><Y><A><F><L><V><N><T><R><H><P><K><I><R><R><Q><I><E><Q><G><M><D><M><V><I><S><S><V><I><G><E><S><Y><R><L><Q><F><D><F><Q><E><A><V><K><N><F><F><P><P><G><N><E><V><V><N><G><E><N><L><S><F><A><Y><E><F><K><A><D><A><L><F><D><F><F><Y><W><F><G><L><S><N><S><V><V><K><V><N><G><K><V><L><N><L><S><S><T><S><P><E><K><K><E><T><I><K><L><F><L><E><K><M><S><E><P><L><I><R><R><S><S><F><S><D><R><K><F><S><V><T><S><R><G><S><I><D><D><V><F><N><C><N><L><S><P><R><S><S><L><T><E><P><L><L><A><E><L><P><F><P><S><V><L><E><S><E><E><T><P><N><Q><F><I> | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.<BOP> | Q5VYS4 |
Q9H668 | STN1_HUMAN | Suppressor of cdc thirteen homolog | Homo | <M><Q><P><G><S><S><R><C><E><E><E><T><P><S><L><L><W><G><L><D><P><V><F><L><A><F><A><K><L><Y><I><R><D><I><L><D><M><K><E><S><R><Q><V><P><G><V><F><L><Y><N><G><H><P><I><K><Q><V><D><V><L><G><T><V><I><G><V><R><E><R><D><A><F><Y><S><Y><G><V><D><D><S><T><G><V><I><N><C><I><C><W><K><K><L><N><T><E><S><V><S><A><A><P><S><A><A><R><E><L><S><L><T><S><Q><L><K><K><L><Q><E><T><I><E><Q><K><T><K><I><E><I><G><D><T><I><R><V><R><G><S><I><R><T><Y><R><E><E><R><E><I><H><A><T><T><Y><Y><K><V><D><D><P><V><W><N><I><Q><I><A><R><M><L><E><L><P><T><I><Y><R><K><V><Y><D><Q><P><F><H><S><S><A><L><E><K><E><E><A><L><S><N><P><G><A><L><D><L><P><S><L><T><S><L><L><S><E><K><A><K><E><F><L><M><E><N><R><V><Q><S><F><Y><Q><Q><E><L><E><M><V><E><S><L><L><S><L><A><N><Q><P><V><I><H><S><A><S><S><D><Q><V><N><F><K><K><D><T><T><S><K><A><I><H><S><I><F><K><N><A><I><Q><L><L><Q><E><K><G><L><V><F><Q><K><D><D><G><F><D><N><L><Y><Y><V><T><R><E><D><K><D><L><H><R><K><I><H><R><I><I><Q><Q><D><C><Q><K><P><N><H><M><E><K><G><C><H><F><L><H><I><L><A><C><A><R><L><S><I><R><P><G><L><S><E><A><V><L><Q><Q><V><L><E><L><L><E><D><Q><S><D><I><V><S><T><M><E><H><Y><Y><T><A><F> | Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<BOP> | Q9H668 |
Q8N3H0 | TAFA2_HUMAN | Chemokine-like protein TAFA-2 | Homo | <M><S><K><R><Y><L><Q><K><A><T><K><G><K><L><L><I><I><I><F><I><V><T><L><W><G><K><V><V><S><S><A><N><H><H><K><A><H><H><V><K><T><G><T><C><E><V><V><A><L><H><R><C><C><N><K><N><K><I><E><E><R><S><Q><T><V><K><C><S><C><F><P><G><Q><V><A><G><T><T><R><A><A><P><S><C><V><D><A><S><I><V><E><Q><K><W><W><C><H><M><Q><P><C><L><E><G><E><E><C><K><V><L><P><D><R><K><G><W><S><C><S><S><G><N><K><V><K><T><T><R><V><T><H> | Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions.<BOP> | Q8N3H0 |
Q96BD0 | SO4A1_HUMAN | Solute carrier family 21 member 12 | Homo | <M><P><L><H><Q><L><G><D><K><P><L><T><F><P><S><P><N><S><A><M><E><N><G><L><D><H><T><P><P><S><R><R><A><S><P><G><T><P><L><S><P><G><S><L><R><S><A><A><H><S><P><L><D><T><S><K><Q><P><L><C><Q><L><W><A><E><K><H><G><A><R><G><T><H><E><V><R><Y><V><S><A><G><Q><S><V><A><C><G><W><W><A><F><A><P><P><C><L><Q><V><L><N><T><P><K><G><I><L><F><F><L><C><A><A><A><F><L><Q><G><M><T><V><N><G><F><I><N><T><V><I><T><S><L><E><R><R><Y><D><L><H><S><Y><Q><S><G><L><I><A><S><S><Y><D><I><A><A><C><L><C><L><T><F><V><S><Y><F><G><G><S><G><H><K><P><R><W><L><G><W><G><V><L><L><M><G><T><G><S><L><V><F><A><L><P><H><F><T><A><G><R><Y><E><V><E><L><D><A><G><V><R><T><C><P><A><N><P><G><A><V><C><A><D><S><T><S><G><L><S><R><Y><Q><L><V><F><M><L><G><Q><F><L><H><G><V><G><A><T><P><L><Y><T><L><G><V><T><Y><L><D><E><N><V><K><S><S><C><S><P><V><Y><I><A><I><F><Y><T><A><A><I><L><G><P><A><A><G><Y><L><I><G><G><A><L><L><N><I><Y><T><E><M><G><R><R><T><E><L><T><T><E><S><P><L><W><V><G><A><W><W><V><G><F><L><G><S><G><A><A><A><F><F><T><A><V><P><I><L><G><Y><P><R><Q><L><P><G><S><Q><R><Y><A><V><M><R><A><A><E><M><H><Q><L><K><D><S><S><R><G><E><A><S><N><P><D><F><G><K><T><I><R><D><L><P><L><S><I><W><L><L><L><K><N><P><T><F><I><L><L><C><L><A><G><A><T><E><A><T><L><I><T><G><M><S><T><F><S><P><K><F><L><E><S><Q><F><S><L><S><A><S><E><A><A><T><L><F><G><Y><L><V><V><P><A><G><G><G><G><T><F><L><G><G><F><F><V><N><K><L><R><L><R><G><S><A><V><I><K><F><C><L><F><C><T><V><V><S><L><L><G><I><L><V><F><S><L><H><C><P><S><V><P><M><A><G><V><T><A><S><Y><G><G><S><L><L><P><E><G><H><L><N><L><T><A><P><C><N><A><A><C><S><C><Q><P><E><H><Y><S><P><V><C><G><S><D><G><L><M><Y><F><S><L><C><H><A><G><C><P><A><A><T><E><T><N><V><D><G><Q><K><V><Y><R><D><C><S><C><I><P><Q><N><L><S><S><G><F><G><H><A><T><A><G><K><C><T><S><T><C><Q><R><K><P><L><L><L><V><F><I><F><V><V><I><F><F><T><F><L><S><S><I><P><A><L><T><A><T><L><R><C><V><R><D><P><Q><R><S><F><A><L><G><I><Q><W><I><V><V><R><I><L><G><G><I><P><G><P><I><A><F><G><W><V><I><D><K><A><C><L><L><W><Q><D><Q><C><G><Q><Q><G><S><C><L><V><Y><Q><N><S><A><M><S><R><Y><I><L><I><M><G><L><L><Y><K><V><L><G><V><L><F><F><A><I><A><C><F><L><Y><K><P><L><S><E><S><S><D><G><L><E><T><C><L><P><S><Q><S><S><A><P><D><S><A><T><D><S><Q><L><Q><S><S><V> | Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. Mediates the transport of estrone-3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) .<BOP> | Q96BD0 |
Q02094 | RHAG_HUMAN | Rhesus blood group-associated glycoprotein | Homo | <M><R><F><T><F><P><L><M><A><I><V><L><E><I><A><M><I><V><L><F><G><L><F><V><E><Y><E><T><D><Q><T><V><L><E><Q><L><N><I><T><K><P><T><D><M><G><I><F><F><E><L><Y><P><L><F><Q><D><V><H><V><M><I><F><V><G><F><G><F><L><M><T><F><L><K><K><Y><G><F><S><S><V><G><I><N><L><L><V><A><A><L><G><L><Q><W><G><T><I><V><Q><G><I><L><Q><S><Q><G><Q><K><F><N><I><G><I><K><N><M><I><N><A><D><F><S><A><A><T><V><L><I><S><F><G><A><V><L><G><K><T><S><P><T><Q><M><L><I><M><T><I><L><E><I><V><F><F><A><H><N><E><Y><L><V><S><E><I><F><K><A><S><D><I><G><A><S><M><T><I><H><A><F><G><A><Y><F><G><L><A><V><A><G><I><L><Y><R><S><G><L><R><K><G><H><E><N><E><E><S><A><Y><Y><S><D><L><F><A><M><I><G><T><L><F><L><W><M><F><W><P><S><F><N><S><A><I><A><E><P><G><D><K><Q><C><R><A><I><V><N><T><Y><F><S><L><A><A><C><V><L><T><A><F><A><F><S><S><L><V><E><H><R><G><K><L><N><M><V><H><I><Q><N><A><T><L><A><G><G><V><A><V><G><T><C><A><D><M><A><I><H><P><F><G><S><M><I><I><G><S><I><A><G><M><V><S><V><L><G><Y><K><F><L><T><P><L><F><T><T><K><L><R><I><H><D><T><C><G><V><H><N><L><H><G><L><P><G><V><V><G><G><L><A><G><I><V><A><V><A><M><G><A><S><N><T><S><M><A><M><Q><A><A><A><L><G><S><S><I><G><T><A><V><V><G><G><L><M><T><G><L><I><L><K><L><P><L><W><G><Q><P><S><D><Q><N><C><Y><D><D><S><V><Y><W><K><V><P><K><T><R> | Associated with rhesus blood group antigen expression . May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane . Involved in ammonia transport across the erythrocyte membrane . Seems to act in monovalent cation transport .<BOP> | Q02094 |
P55039 | DRG2_HUMAN | Translation factor GTPase DRG2 | Homo | <M><G><I><L><E><K><I><S><E><I><E><K><E><I><A><R><T><Q><K><N><K><A><T><E><Y><H><L><G><L><L><K><A><K><L><A><K><Y><R><A><Q><L><L><E><P><S><K><S><A><S><S><K><G><E><G><F><D><V><M><K><S><G><D><A><R><V><A><L><I><G><F><P><S><V><G><K><S><T><F><L><S><L><M><T><S><T><A><S><E><A><A><S><Y><E><F><T><T><L><T><C><I><P><G><V><I><E><Y><K><G><A><N><I><Q><L><L><D><L><P><G><I><I><E><G><A><A><Q><G><K><G><R><G><R><Q><V><I><A><V><A><R><T><A><D><V><I><I><M><M><L><D><A><T><K><G><E><V><Q><R><S><L><L><E><K><E><L><E><S><V><G><I><R><L><N><K><H><K><P><N><I><Y><F><K><P><K><K><G><G><G><I><S><F><N><S><T><V><T><L><T><Q><C><S><E><K><L><V><Q><L><I><L><H><E><Y><K><I><F><N><A><E><V><L><F><R><E><D><C><S><P><D><E><F><I><D><V><I><V><G><N><R><V><Y><M><P><C><L><Y><V><Y><N><K><I><D><Q><I><S><M><E><E><V><D><R><L><A><R><K><P><N><S><V><V><I><S><C><G><M><K><L><N><L><D><Y><L><L><E><M><L><W><E><Y><L><A><L><T><C><I><Y><T><K><K><R><G><Q><R><P><D><F><T><D><A><I><I><L><R><K><G><A><S><V><E><H><V><C><H><R><I><H><R><S><L><A><S><Q><F><K><Y><A><L><V><W><G><T><S><T><K><Y><S><P><Q><R><V><G><L><T><H><T><M><E><H><E><D><V><I><Q><I><V><K><K> | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation.<BOP> | P55039 |
P54368 | OAZ1_HUMAN | Ornithine decarboxylase antizyme 1 | Homo | <M><V><K><S><S><L><Q><R><I><L><N><S><H><C><F><A><R><E><K><E><G><D><K><P><S><A><T><I><H><A><S><R><T><M><P><L><L><S><L><H><S><R><G><G><S><S><S><E><S><S><R><V><S><L><H><C><C><S><N><P><G><P><G><P><R><W><C><S><D><A><P><H><P><P><L><K><I><P><G><G><R><G><N><S><Q><R><D><H><N><L><S><A><N><L><F><Y><S><D><D><R><L><N><V><T><E><E><L><T><S><N><D><K><T><R><I><L><N><V><Q><S><R><L><T><D><A><K><R><I><N><W><R><T><V><L><S><G><G><S><L><Y><I><E><I><P><G><G><A><L><P><E><G><S><K><D><S><F><A><V><L><L><E><F><A><E><E><Q><L><R><A><D><H><V><F><I><C><F><H><K><N><R><E><D><R><A><A><L><L><R><T><F><S><F><L><G><F><E><I><V><R><P><G><H><P><L><V><P><K><R><P><D><A><C><F><M><A><Y><T><F><E><R><E><S><S><G><E><E><E><E> | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome . Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC . Stabilizes AZIN2 by interfering with its ubiquitination . Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol .<BOP> | P54368 |
Q86YE8 | ZN573_HUMAN | Zinc finger protein 573 | Homo | <M><F><P><V><L><E><P><H><Q><V><G><L><I><R><S><Y><N><S><K><T><M><T><C><F><Q><E><L><V><T><F><R><D><V><A><I><D><F><S><R><Q><E><W><E><Y><L><D><P><N><Q><R><D><L><Y><R><D><V><M><L><E><N><Y><R><N><L><V><S><L><G><G><H><S><I><S><K><P><V><V><V><D><L><L><E><R><G><K><E><P><W><M><I><L><R><E><E><T><Q><F><T><D><L><D><L><Q><C><E><I><I><S><Y><I><E><V><P><T><Y><E><T><D><I><S><S><T><Q><L><Q><S><I><Y><K><R><E><K><L><Y><E><C><K><K><C><Q><K><K><F><S><S><G><Y><Q><L><I><L><H><H><R><F><H><V><I><E><R><P><Y><E><C><K><E><C><G><K><N><F><R><S><G><Y><Q><L><T><L><H><Q><R><F><H><T><G><E><K><P><Y><E><C><T><E><C><G><K><N><F><R><S><G><Y><Q><L><T><V><H><Q><R><F><H><T><G><E><K><T><Y><E><C><R><Q><C><G><K><A><F><I><Y><A><S><H><I><V><Q><H><E><R><I><H><T><G><G><K><P><Y><E><C><Q><E><C><G><R><A><F><S><Q><G><G><H><L><R><I><H><Q><R><V><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><T><F><S><R><R><S><N><L><V><E><H><G><Q><F><H><T><D><E><K><P><Y><I><C><E><K><C><G><K><A><F><R><R><G><H><Q><L><T><V><H><Q><R><V><H><T><G><K><K><P><Y><E><C><K><E><C><G><K><G><Y><T><T><A><S><Y><F><L><L><H><Q><R><I><H><K><G><G><K><P><Y><E><C><K><E><C><K><K><T><F><T><L><Y><R><N><L><T><R><H><Q><N><I><H><T><G><E><K><L><F><E><C><K><Q><C><G><K><T><Y><T><T><G><S><K><L><F><Q><H><Q><K><T><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><S><L><Y><G><Y><L><K><Q><H><Q><K><I><H><T><G><M><K><H><F><E><C><K><E><C><K><K><T><F><T><L><Y><R><N><L><T><R><H><Q><N><I><H><T><G><K><K><L><F><E><C><Q><E><C><G><K><A><Y><S><T><G><S><N><L><I><Q><H><R><K><T><H><T><G><E><K><P><Y><K><C><K><E><C><G><K><T><F><S><L><H><G><Y><L><N><Q><H><Q><K><I><H><T><G><M><K><P><Y><E><C><K><V><C><R><K><T><F><T><F><Y><R><N><L><T><L><H><Q><S><I><H><T><D><E><K><P><F><E><C><K><E><C><G><K><T><F><R><R><S><S><H><L><T><A><H><Q><S><I><H><A><D><K><K><P><Y><E><C><K><E><C><G><K><A><F><K><M><Y><G><Y><L><T><Q><H><Q><K><I><H><T><G><G><K><P><Y><E><C><K><E><C><G><K><A><F><S><R><A><S><N><L><V><Q><H><E><R><I><H><T><G><E><K><P><Y><V><C><K><Q><C><G><K><T><F><R><Y><G><S><A><L><K><A><H><Q><R><I><H><R><S><I><K><V> | May be involved in transcriptional regulation.<BOP> | Q86YE8 |
P01824 | HV439_HUMAN | Ig heavy chain V-II region WAH | Homo | <M><D><L><M><C><K><K><M><K><H><L><W><F><F><L><L><L><V><A><A><P><R><W><V><L><S><Q><L><Q><L><Q><E><S><G><P><G><L><V><K><P><S><E><T><L><S><L><T><C><T><V><S><G><G><S><I><S><S><S><S><Y><Y><W><G><W><I><R><Q><P><P><G><K><G><L><E><W><I><G><S><I><Y><Y><S><G><S><T><Y><Y><N><P><S><L><K><S><R><V><T><I><S><V><D><T><S><K><N><Q><F><S><L><K><L><S><S><V><T><A><A><D><T><A><V><Y><Y><C><A><R> | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP> | P01824 |
Q00587 | BORG5_HUMAN | Serum protein MSE55 | Homo | <M><P><G><P><Q><G><G><R><G><A><A><T><M><S><L><G><K><L><S><P><V><G><W><V><S><S><S><Q><G><K><R><R><L><T><A><D><M><I><S><H><P><L><G><D><F><R><H><T><M><H><V><G><R><G><G><D><V><F><G><D><T><S><F><L><S><N><H><G><G><S><S><G><S><T><H><R><S><P><R><S><F><L><A><K><K><L><Q><L><V><R><R><V><G><A><P><P><R><R><M><A><S><P><P><A><P><S><P><A><P><P><A><I><S><P><I><I><K><N><A><I><S><L><P><Q><L><N><Q><A><A><Y><D><S><L><V><V><G><K><L><S><F><D><S><S><P><T><S><S><T><D><G><H><S><S><Y><G><L><D><S><G><F><C><T><I><S><R><L><P><R><S><E><K><P><H><D><R><D><R><D><G><S><F><P><S><E><P><G><L><R><R><S><D><S><L><L><S><F><R><L><D><L><D><L><G><P><S><L><L><S><E><L><L><G><V><M><S><L><P><E><A><P><A><A><E><T><P><A><P><A><A><N><P><P><A><P><T><A><N><P><T><G><P><A><A><N><P><P><A><T><T><A><N><P><P><A><P><A><A><N><P><S><A><P><A><A><T><P><T><G><P><A><A><N><P><P><A><P><A><A><S><S><T><P><H><G><H><C><P><N><G><V><T><A><G><L><G><P><V><A><E><V><K><S><S><P><V><G><G><G><P><R><G><P><A><G><P><A><L><G><R><H><W><G><A><G><W><D><G><G><H><H><Y><P><E><M><D><A><R><Q><E><R><V><E><V><L><P><Q><A><R><A><S><W><E><S><L><D><E><E><W><R><A><P><Q><A><G><S><R><T><P><V><P><S><T><V><Q><A><N><T><F><E><F><A><D><A><E><E><D><D><E><V><K><V> | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.<BOP> | Q00587 |
H3BRN8 | PIRC2_HUMAN | Piercer of microtubule wall 2 protein | Homo | <M><T><D><R><N><R><D><K><K><S><T><S><P><S><N><S><D><T><E><M><K><S><E><Q><L><P><P><C><V><N><P><G><N><P><V><F><S><C><M><L><D><P><K><T><L><Q><T><A><T><S><L><S><K><P><Q><M><I><M><Y><K><T><N><S><S><H><Y><G><E><F><L><P><I><P><Q><F><F><P><C><N><Y><T><P><K><E><Q><V><F><S><S><H><I><R><A><T><G><F><Y><Q><N><N><T><L><N><T><A><P><D><R><T><R><T><L><D><F><P><N><I><Q><H><T><L> | Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.<BOP> | H3BRN8 |
P15814 | IGLL1_HUMAN | Immunoglobulin-related protein 14.1 | Homo | <M><R><P><G><T><G><Q><G><G><L><E><A><P><G><E><P><G><P><N><L><R><Q><R><W><P><L><L><L><L><G><L><A><V><V><T><H><G><L><L><R><P><T><A><A><S><Q><S><R><A><L><G><P><G><A><P><G><G><S><S><R><S><S><L><R><S><R><W><G><R><F><L><L><Q><R><G><S><W><T><G><P><R><C><W><P><R><G><F><Q><S><K><H><N><S><V><T><H><V><F><G><S><G><T><Q><L><T><V><L><S><Q><P><K><A><T><P><S><V><T><L><F><P><P><S><S><E><E><L><Q><A><N><K><A><T><L><V><C><L><M><N><D><F><Y><P><G><I><L><T><V><T><W><K><A><D><G><T><P><I><T><Q><G><V><E><M><T><T><P><S><K><Q><S><N><N><K><Y><A><A><S><S><Y><L><S><L><T><P><E><Q><W><R><S><R><R><S><Y><S><C><Q><V><M><H><E><G><S><T><V><E><K><T><V><A><P><A><E><C><S> | Critical for B-cell development.<BOP> | P15814 |
Q9Y3L3 | 3BP1_HUMAN | SH3 domain-binding protein 1 | Homo | <M><M><K><R><Q><L><H><R><M><R><Q><L><A><Q><T><G><S><L><G><R><T><P><E><T><A><E><F><L><G><E><D><L><L><Q><V><E><Q><R><L><E><P><A><K><R><A><A><H><N><I><H><K><R><L><Q><A><C><L><Q><G><Q><S><G><A><D><M><D><K><R><V><K><K><L><P><L><M><A><L><S><T><T><M><A><E><S><F><K><E><L><D><P><D><S><S><M><G><K><A><L><E><M><S><C><A><I><Q><N><Q><L><A><R><I><L><A><E><F><E><M><T><L><E><R><D><V><L><Q><P><L><S><R><L><S><E><E><E><L><P><A><I><L><K><H><K><K><S><L><Q><K><L><V><S><D><W><N><T><L><K><S><R><L><S><Q><A><T><K><N><S><G><S><S><Q><G><L><G><G><S><P><G><S><H><S><H><T><T><M><A><N><K><V><E><T><L><K><E><E><E><E><E><L><K><R><K><V><E><Q><C><R><D><E><Y><L><A><D><L><Y><H><F><V><T><K><E><D><S><Y><A><N><Y><F><I><R><L><L><E><I><Q><A><D><Y><H><R><R><S><L><S><S><L><D><T><A><L><A><E><L><R><E><N><H><G><Q><A><D><H><S><P><S><M><T><A><T><H><F><P><R><V><Y><G><V><S><L><A><T><H><L><Q><E><L><G><R><E><I><A><L><P><I><E><A><C><V><M><M><L><L><S><E><G><M><K><E><E><G><L><F><R><L><A><A><G><A><S><V><L><K><R><L><K><Q><T><M><A><S><D><P><H><S><L><E><E><F><C><S><D><P><H><A><V><A><G><A><L><K><S><Y><L><R><E><L><P><E><P><L><M><T><F><D><L><Y><D><D><W><M><R><A><A><S><L><K><E><P><G><A><R><L><Q><A><L><Q><E><V><C><S><R><L><P><P><E><N><L><S><N><L><R><Y><L><M><K><F><L><A><R><L><A><E><E><Q><E><V><N><K><M><T><P><S><N><I><A><I><V><L><G><P><N><L><L><W><P><P><E><K><E><G><D><Q><A><Q><L><D><A><A><S><V><S><S><I><Q><V><V><G><V><V><E><A><L><I><Q><S><A><D><T><L><F><P><G><D><I><N><F><N><V><S><G><L><F><S><A><V><T><L><Q><D><T><V><S><D><R><L><A><S><E><E><L><P><S><T><A><V><P><T><P><A><T><T><P><A><P><A><P><A><P><A><P><A><P><A><P><A><L><A><S><A><A><T><K><E><R><T><E><S><E><V><P><P><R><P><A><S><P><K><V><T><R><S><P><P><E><T><A><A><P><V><E><D><M><A><R><R><T><K><R><P><A><P><A><R><P><T><M><P><P><P><Q><V><S><G><S><R><S><S><P><P><A><P><P><L><P><P><G><S><G><S><P><G><T><P><Q><A><L><P><R><R><L><V><G><S><S><L><R><A><P><T><V><P><P><P><L><P><P><T><P><P><Q><P><A><R><R><Q><S><R><R><S><P><A><S><P><S><P><A><S><P><G><P><A><S><P><S><P><V><S><L><S><N><P><A><Q><V><D><L><G><A><A><T><A><E><G><G><A><P><E><A><I><S><G><V><P><T><P><P><A><I><P><P><Q><P><R><P><R><S><L><A><S><E><T><N> | GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration . Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions . Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment . It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells .<BOP> | Q9Y3L3 |
Q6GTX8 | LAIR1_HUMAN | Leukocyte-associated immunoglobulin-like receptor 1 | Homo | <M><S><P><H><P><T><A><L><L><G><L><V><L><C><L><A><Q><T><I><H><T><Q><E><E><D><L><P><R><P><S><I><S><A><E><P><G><T><V><I><P><L><G><S><H><V><T><F><V><C><R><G><P><V><G><V><Q><T><F><R><L><E><R><D><S><R><S><T><Y><N><D><T><E><D><V><S><Q><A><S><P><S><E><S><E><A><R><F><R><I><D><S><V><R><E><G><N><A><G><L><Y><R><C><I><Y><Y><K><P><P><K><W><S><E><Q><S><D><Y><L><E><L><L><V><K><E><S><S><G><G><P><D><S><P><D><T><E><P><G><S><S><A><G><P><T><Q><R><P><S><D><N><S><H><N><E><H><A><P><A><S><Q><G><L><K><A><E><H><L><Y><I><L><I><G><V><S><V><V><F><L><F><C><L><L><L><L><V><L><F><C><L><H><R><Q><N><Q><I><K><Q><G><P><P><R><S><K><D><E><E><Q><K><P><Q><Q><R><P><D><L><A><V><D><V><L><E><R><T><A><D><K><A><T><V><N><G><L><P><E><K><D><R><E><T><D><T><S><A><L><A><A><G><S><S><Q><E><V><T><Y><A><Q><L><D><H><W><A><L><T><Q><R><T><A><R><A><V><S><P><Q><S><T><K><P><M><A><E><S><I><T><Y><A><A><V><A><R><H> | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.<BOP> | Q6GTX8 |
P48742 | LHX1_HUMAN | Homeobox protein Lim-1 | Homo | <M><V><H><C><A><G><C><K><R><P><I><L><D><R><F><L><L><N><V><L><D><R><A><W><H><V><K><C><V><Q><C><C><E><C><K><C><N><L><T><E><K><C><F><S><R><E><G><K><L><Y><C><K><N><D><F><F><R><C><F><G><T><K><C><A><G><C><A><Q><G><I><S><P><S><D><L><V><R><R><A><R><S><K><V><F><H><L><N><C><F><T><C><M><M><C><N><K><Q><L><S><T><G><E><E><L><Y><I><I><D><E><N><K><F><V><C><K><E><D><Y><L><S><N><S><S><V><A><K><E><N><S><L><H><S><A><T><T><G><S><D><P><S><L><S><P><D><S><Q><D><P><S><Q><D><D><A><K><D><S><E><S><A><N><V><S><D><K><E><A><G><S><N><E><N><D><D><Q><N><L><G><A><K><R><R><G><P><R><T><T><I><K><A><K><Q><L><E><T><L><K><A><A><F><A><A><T><P><K><P><T><R><H><I><R><E><Q><L><A><Q><E><T><G><L><N><M><R><V><I><Q><V><W><F><Q><N><R><R><S><K><E><R><R><M><K><Q><L><S><A><L><G><A><R><R><H><A><F><F><R><S><P><R><R><M><R><P><L><V><D><R><L><E><P><G><E><L><I><P><N><G><P><F><S><F><Y><G><D><Y><Q><S><E><Y><Y><G><P><G><G><N><Y><D><F><F><P><Q><G><P><P><S><S><Q><A><Q><T><P><V><D><L><P><F><V><P><S><S><G><P><S><G><T><P><L><G><G><L><E><H><P><L><P><G><H><H><P><S><S><E><A><Q><R><F><T><D><I><L><A><H><P><P><G><D><S><P><S><P><E><P><S><L><P><G><P><L><H><S><M><S><A><E><V><F><G><P><S><P><P><F><S><S><L><S><V><N><G><G><A><S><Y><G><N><H><L><S><H><P><P><E><M><N><E><A><A><V><W> | Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.<BOP> | P48742 |
Q9H5N1 | RABE2_HUMAN | Rabaptin-5beta | Homo | <M><A><A><A><A><P><V><A><A><D><D><D><E><R><R><R><R><P><G><A><A><L><E><D><S><R><S><Q><E><G><A><N><G><E><A><E><S><G><E><L><S><R><L><R><A><E><L><A><G><A><L><A><E><M><E><T><M><K><A><V><A><E><V><S><E><S><T><K><A><E><A><V><A><A><V><Q><R><Q><C><Q><E><E><V><A><S><L><Q><A><I><L><K><D><S><I><S><S><Y><E><A><Q><I><T><A><L><K><Q><E><R><Q><Q><Q><Q><Q><D><C><E><E><K><E><R><E><L><G><R><L><K><Q><L><L><S><R><A><Y><P><L><D><S><L><E><K><Q><M><E><K><A><H><E><D><S><E><K><L><R><E><I><V><L><P><M><E><K><E><I><E><E><L><K><A><K><L><L><R><A><E><E><L><I><Q><E><I><Q><R><R><P><R><H><A><P><S><L><H><G><S><T><E><L><L><P><L><S><R><D><P><S><P><P><L><E><P><L><E><E><L><S><G><D><G><G><P><A><A><E><A><F><A><H><N><C><D><D><S><A><S><I><S><S><F><S><L><G><G><G><V><G><S><S><S><S><L><P><Q><S><R><Q><G><L><S><P><E><Q><E><E><T><A><S><L><V><S><T><G><T><L><V><P><E><G><I><Y><L><P><P><P><G><Y><Q><L><V><P><D><T><Q><W><E><Q><L><Q><T><E><G><R><Q><L><Q><K><D><L><E><S><V><S><R><E><R><D><E><L><Q><E><G><L><R><R><S><N><E><D><C><A><K><Q><M><Q><V><L><L><A><Q><V><Q><N><S><E><Q><L><L><R><T><L><Q><G><T><V><S><Q><A><Q><E><R><V><Q><L><Q><M><A><E><L><V><T><T><H><K><C><L><H><H><E><V><K><R><L><N><E><E><N><Q><G><L><R><A><E><Q><L><P><S><S><A><P><Q><G><S><Q><Q><E><Q><G><E><E><E><S><L><P><S><S><V><P><E><L><Q><Q><L><L><C><C><T><R><Q><E><A><R><A><R><L><Q><A><Q><E><H><G><A><E><R><L><R><I><E><I><V><T><L><R><E><A><L><E><E><E><T><V><A><R><A><S><L><E><G><Q><L><R><V><Q><R><E><E><T><E><V><L><E><A><S><L><C><S><L><R><T><E><M><E><R><V><Q><Q><E><Q><S><K><A><Q><L><P><D><L><L><S><E><Q><R><A><K><V><L><R><L><Q><A><E><L><E><T><S><E><Q><V><Q><R><D><F><V><R><L><S><Q><A><L><Q><V><R><L><E><R><I><R><Q><A><E><T><L><E><Q><V><R><S><I><M><D><E><A><P><L><T><D><V><R><D><I><K><D><T> | Plays a role in membrane trafficking and in homotypic early endosome fusion . Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking . By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis .<BOP> | Q9H5N1 |
P51511 | MMP15_HUMAN | SMCP-2 | Homo | <M><G><S><D><P><S><A><P><G><R><P><G><W><T><G><S><L><L><G><D><R><E><E><A><A><R><P><R><L><L><P><L><L><L><V><L><L><G><C><L><G><L><G><V><A><A><E><D><A><E><V><H><A><E><N><W><L><R><L><Y><G><Y><L><P><Q><P><S><R><H><M><S><T><M><R><S><A><Q><I><L><A><S><A><L><A><E><M><Q><R><F><Y><G><I><P><V><T><G><V><L><D><E><E><T><K><E><W><M><K><R><P><R><C><G><V><P><D><Q><F><G><V><R><V><K><A><N><L><R><R><R><R><K><R><Y><A><L><T><G><R><K><W><N><N><H><H><L><T><F><S><I><Q><N><Y><T><E><K><L><G><W><Y><H><S><M><E><A><V><R><R><A><F><R><V><W><E><Q><A><T><P><L><V><F><Q><E><V><P><Y><E><D><I><R><L><R><R><Q><K><E><A><D><I><M><V><L><F><A><S><G><F><H><G><D><S><S><P><F><D><G><T><G><G><F><L><A><H><A><Y><F><P><G><P><G><L><G><G><D><T><H><F><D><A><D><E><P><W><T><F><S><S><T><D><L><H><G><N><N><L><F><L><V><A><V><H><E><L><G><H><A><L><G><L><E><H><S><S><N><P><N><A><I><M><A><P><F><Y><Q><W><K><D><V><D><N><F><K><L><P><E><D><D><L><R><G><I><Q><Q><L><Y><G><T><P><D><G><Q><P><Q><P><T><Q><P><L><P><T><V><T><P><R><R><P><G><R><P><D><H><R><P><P><R><P><P><Q><P><P><P><P><G><G><K><P><E><R><P><P><K><P><G><P><P><V><Q><P><R><A><T><E><R><P><D><Q><Y><G><P><N><I><C><D><G><D><F><D><T><V><A><M><L><R><G><E><M><F><V><F><K><G><R><W><F><W><R><V><R><H><N><R><V><L><D><N><Y><P><M><P><I><G><H><F><W><R><G><L><P><G><D><I><S><A><A><Y><E><R><Q><D><G><R><F><V><F><F><K><G><D><R><Y><W><L><F><R><E><A><N><L><E><P><G><Y><P><Q><P><L><T><S><Y><G><L><G><I><P><Y><D><R><I><D><T><A><I><W><W><E><P><T><G><H><T><F><F><F><Q><E><D><R><Y><W><R><F><N><E><E><T><Q><R><G><D><P><G><Y><P><K><P><I><S><V><W><Q><G><I><P><A><S><P><K><G><A><F><L><S><N><D><A><A><Y><T><Y><F><Y><K><G><T><K><Y><W><K><F><D><N><E><R><L><R><M><E><P><G><Y><P><K><S><I><L><R><D><F><M><G><C><Q><E><H><V><E><P><G><P><R><W><P><D><V><A><R><P><P><F><N><P><H><G><G><A><E><P><G><A><D><S><A><E><G><D><V><G><D><G><D><G><D><F><G><A><G><V><N><K><D><G><G><S><R><V><V><V><Q><M><E><E><V><A><R><T><V><N><V><V><M><V><L><V><P><L><L><L><L><L><C><V><L><G><L><T><Y><A><L><V><Q><M><Q><R><K><G><A><P><R><V><L><L><Y><C><K><R><S><L><Q><E><W><V> | Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.<BOP> | P51511 |
Q9ULZ9 | MMP17_HUMAN | Membrane-type-4 matrix metalloproteinase | Homo | <M><R><R><R><A><A><R><G><P><G><P><P><P><P><G><P><G><L><S><R><L><P><L><P><L><L><L><L><L><A><L><G><T><R><G><G><C><A><A><P><A><P><A><P><R><A><E><D><L><S><L><G><V><E><W><L><S><R><F><G><Y><L><P><P><A><D><P><T><T><G><Q><L><Q><T><Q><E><E><L><S><K><A><I><T><A><M><Q><Q><F><G><G><L><E><A><T><G><I><L><D><E><A><T><L><A><L><M><K><T><P><R><C><S><L><P><D><L><P><V><L><T><Q><A><R><R><R><R><Q><A><P><A><P><T><K><W><N><K><R><N><L><S><W><R><V><R><T><F><P><R><D><S><P><L><G><H><D><T><V><R><A><L><M><Y><Y><A><L><K><V><W><S><D><I><A><P><L><N><F><H><E><V><A><G><S><A><A><D><I><Q><I><D><F><S><K><A><D><H><N><D><G><Y><P><F><D><G><P><G><G><T><V><A><H><A><F><F><P><G><H><H><H><T><A><G><D><T><H><F><D><D><D><E><A><W><T><F><R><S><S><D><A><H><G><M><D><L><F><A><V><A><V><H><E><F><G><H><A><I><G><L><S><H><V><A><A><A><H><S><I><M><R><P><Y><Y><Q><G><P><V><G><D><P><L><R><Y><G><L><P><Y><E><D><K><V><R><V><W><Q><L><Y><G><V><R><E><S><V><S><P><T><A><Q><P><E><E><P><P><L><L><P><E><P><P><D><N><R><S><S><A><P><P><R><K><D><V><P><H><R><C><S><T><H><F><D><A><V><A><Q><I><R><G><E><A><F><F><F><K><G><K><Y><F><W><R><L><T><R><D><R><H><L><V><S><L><Q><P><A><Q><M><H><R><F><W><R><G><L><P><L><H><L><D><S><V><D><A><V><Y><E><R><T><S><D><H><K><I><V><F><F><K><G><D><R><Y><W><V><F><K><D><N><N><V><E><E><G><Y><P><R><P><V><S><D><F><S><L><P><P><G><G><I><D><A><A><F><S><W><A><H><N><D><R><T><Y><F><F><K><D><Q><L><Y><W><R><Y><D><D><H><T><R><H><M><D><P><G><Y><P><A><Q><S><P><L><W><R><G><V><P><S><T><L><D><D><A><M><R><W><S><D><G><A><S><Y><F><F><R><G><Q><E><Y><W><K><V><L><D><G><E><L><E><V><A><P><G><Y><P><Q><S><T><A><R><D><W><L><V><C><G><D><S><Q><A><D><G><S><V><A><A><G><V><D><A><A><E><G><P><R><A><P><P><G><Q><H><D><Q><S><R><S><E><D><G><Y><E><V><C><S><C><T><S><G><A><S><S><P><P><G><A><P><G><P><L><V><A><A><T><M><L><L><L><L><P><P><L><S><P><G><A><L><W><T><A><A><Q><A><L><T><L> | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.<BOP> | Q9ULZ9 |
Q9H741 | SPRNG_HUMAN | SREBF pathway regulator in Golgi 1 | Homo | <M><V><N><L><A><A><M><V><W><R><R><L><L><R><K><R><W><V><L><A><L><V><F><G><L><S><L><V><Y><F><L><S><S><T><F><K><Q><E><E><R><A><V><R><D><R><N><L><L><Q><V><H><D><H><N><Q><P><I><P><W><K><V><Q><F><N><L><G><N><S><S><R><P><S><N><Q><C><R><N><S><I><Q><G><K><H><L><I><T><D><E><L><G><Y><V><C><E><R><K><D><L><L><V><N><G><C><C><N><V><N><V><P><S><T><K><Q><Y><C><C><D><G><C><W><P><N><G><C><C><S><A><Y><E><Y><C><V><S><C><C><L><Q><P><N><K><Q><L><L><L><E><R><F><L><N><R><A><A><V><A><F><Q><N><L><F><M><A><V><E><D><H><F><E><L><C><L><A><K><C><R><T><S><S><Q><S><V><Q><H><E><N><T><Y><R><D><P><I><A><K><Y><C><Y><G><E><S><P><P><E><L><F><P><A> | Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.<BOP> | Q9H741 |
P29350 | PTN6_HUMAN | SH-PTP1 | Homo | <M><V><R><W><F><H><R><D><L><S><G><L><D><A><E><T><L><L><K><G><R><G><V><H><G><S><F><L><A><R><P><S><R><K><N><Q><G><D><F><S><L><S><V><R><V><G><D><Q><V><T><H><I><R><I><Q><N><S><G><D><F><Y><D><L><Y><G><G><E><K><F><A><T><L><T><E><L><V><E><Y><Y><T><Q><Q><Q><G><V><L><Q><D><R><D><G><T><I><I><H><L><K><Y><P><L><N><C><S><D><P><T><S><E><R><W><Y><H><G><H><M><S><G><G><Q><A><E><T><L><L><Q><A><K><G><E><P><W><T><F><L><V><R><E><S><L><S><Q><P><G><D><F><V><L><S><V><L><S><D><Q><P><K><A><G><P><G><S><P><L><R><V><T><H><I><K><V><M><C><E><G><G><R><Y><T><V><G><G><L><E><T><F><D><S><L><T><D><L><V><E><H><F><K><K><T><G><I><E><E><A><S><G><A><F><V><Y><L><R><Q><P><Y><Y><A><T><R><V><N><A><A><D><I><E><N><R><V><L><E><L><N><K><K><Q><E><S><E><D><T><A><K><A><G><F><W><E><E><F><E><S><L><Q><K><Q><E><V><K><N><L><H><Q><R><L><E><G><Q><R><P><E><N><K><G><K><N><R><Y><K><N><I><L><P><F><D><H><S><R><V><I><L><Q><G><R><D><S><N><I><P><G><S><D><Y><I><N><A><N><Y><I><K><N><Q><L><L><G><P><D><E><N><A><K><T><Y><I><A><S><Q><G><C><L><E><A><T><V><N><D><F><W><Q><M><A><W><Q><E><N><S><R><V><I><V><M><T><T><R><E><V><E><K><G><R><N><K><C><V><P><Y><W><P><E><V><G><M><Q><R><A><Y><G><P><Y><S><V><T><N><C><G><E><H><D><T><T><E><Y><K><L><R><T><L><Q><V><S><P><L><D><N><G><D><L><I><R><E><I><W><H><Y><Q><Y><L><S><W><P><D><H><G><V><P><S><E><P><G><G><V><L><S><F><L><D><Q><I><N><Q><R><Q><E><S><L><P><H><A><G><P><I><I><V><H><C><S><A><G><I><G><R><T><G><T><I><I><V><I><D><M><L><M><E><N><I><S><T><K><G><L><D><C><D><I><D><I><Q><K><T><I><Q><M><V><R><A><Q><R><S><G><M><V><Q><T><E><A><Q><Y><K><F><I><Y><V><A><I><A><Q><F><I><E><T><T><K><K><K><L><E><V><L><Q><S><Q><K><G><Q><E><S><E><Y><G><N><I><T><Y><P><P><A><M><K><N><A><H><A><K><A><S><R><T><S><S><K><H><K><E><D><V><Y><E><N><L><H><T><K><N><K><R><E><E><K><V><K><K><Q><R><S><A><D><K><E><K><S><K><G><S><L><K><R><K> | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<BOP> | P29350 |
Q8NGA8 | O4F17_HUMAN | Olfactory receptor 4F19 | Homo | <M><V><T><E><F><I><F><L><G><L><S><D><S><Q><G><L><Q><T><F><L><F><M><L><F><F><V><F><Y><G><G><I><V><F><G><N><L><L><I><V><I><T><V><V><S><D><S><H><L><H><S><P><M><Y><F><L><L><A><N><L><S><L><I><D><L><S><L><S><S><V><T><A><P><K><M><I><T><D><F><F><S><Q><R><K><V><I><S><F><K><G><C><L><V><Q><I><F><L><L><H><F><F><G><G><S><E><M><V><I><L><I><A><M><G><F><D><R><Y><I><A><I><C><K><P><L><H><Y><T><T><I><M><C><G><N><A><C><V><G><I><M><A><V><A><W><G><I><G><F><L><H><S><V><S><Q><L><A><F><A><V><H><L><P><F><C><G><P><N><E><V><D><S><F><Y><C><D><L><P><R><V><I><K><L><A><C><T><D><T><Y><R><L><D><I><M><V><I><A><N><S><G><V><L><T><V><C><S><F><V><L><L><I><I><S><Y><T><I><I><L><M><T><I><Q><H><R><P><L><D><K><S><S><K><A><L><S><T><L><T><A><H><I><T><V><V><L><L><F><F><G><P><C><V><F><I><Y><A><W><P><F><P><I><K><S><L><D><K><F><L><A><V><F><Y><S><V><I><T><P><L><L><N><P><I><I><Y><T><L><R><N><K><D><M><K><T><A><I><R><Q><L><R><K><W><D><A><H><S><S><V><K><F> | Odorant receptor.<BOP> | Q8NGA8 |
Q9NRN7 | ADPPT_HUMAN | LYS5 ortholog | Homo | <M><V><F><P><A><K><R><F><C><L><V><P><S><M><E><G><V><R><W><A><F><S><C><G><T><W><L><P><S><R><A><E><W><L><L><A><V><R><S><I><Q><P><E><E><K><E><R><I><G><Q><F><V><F><A><R><D><A><K><A><A><M><A><G><R><L><M><I><R><K><L><V><A><E><K><L><N><I><P><W><N><H><I><R><L><Q><R><T><A><K><G><K><P><V><L><A><K><D><S><S><N><P><Y><P><N><F><N><F><N><I><S><H><Q><G><D><Y><A><V><L><A><A><E><P><E><L><Q><V><G><I><D><I><M><K><T><S><F><P><G><R><G><S><I><P><E><F><F><H><I><M><K><R><K><F><T><N><K><E><W><E><T><I><R><S><F><K><D><E><W><T><Q><L><D><M><F><Y><R><N><W><A><L><K><E><S><F><I><K><A><I><G><V><G><L><G><F><E><L><Q><R><L><E><F><D><L><S><P><L><N><L><D><I><G><Q><V><Y><K><E><T><R><L><F><L><D><G><E><E><E><K><E><W><A><F><E><E><S><K><I><D><E><H><H><F><V><A><V><A><L><R><K><P><D><G><S><R><H><Q><D><V><P><S><Q><D><D><S><K><P><T><Q><R><Q><F><T><I><L><N><F><N><D><L><M><S><S><A><V><P><M><T><P><E><D><P><S><F><W><D><C><F><C><F><T><E><E><I><P><I><R><N><G><T><K><S> | Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.<BOP> | Q9NRN7 |
A0A0U1RQE8 | GLYLB_HUMAN | Putative glycine N-acyltransferase-like protein 1B | Homo | <M><I><L><L><N><N><S><E><R><L><L><A><L><F><K><S><L><A><R><S><I><P><E><S><L><K><V><Y><G><S><L><F><H><I><N><H><G><N><P><F><N><M><E><V><L><V><D><S><W><P><E><Y><Q><M><V><I><I><R><P><Q><K><Q><E><M><T><D><D><M><D><S><Y><T><N><V><Y><R><V><F><S><K><D><P><Q><K><S><Q><E><V><L><K><N><S><E><I><I><N><W><K><Q><K><L><Q><I><Q><G><F><Q><E><S><L><G><E><G><I><R><A><A><A><F><S><N><S><V><K><V><E><H><S><R><A><L><L><F><V><T><E><D><I><L><K><L><Y><A><T><N><K><S><K><L><G><S><W><A><E><T><G><H><P><D><D><E><L><E><S><E><T><P><N><F><K><Y><A><Q><L><N><V><S><Y><S><G><L><V><N><D><N><W><K><L><G><M><N><K><R><S><L><R><Y><I><K><R><C><L><G><A><L><P><A><A><C><M><L><G><P><E><G><V><P><V><S><W><V><T><M><D><P><S><C><E><I><G><M><G><Y><S><V><E><K><Y><R><R><R><G><N><G><T><R><L><I><M><R><C><M><K><Y><L><C><Q><K><N><I><P><F><Y><G><S><V><L><E><E><N><Q><G><V><I><R><K><T><S><A><L><G><F><L><E><A><S><C><Q><W><H><Q><W><N><C><Y><P><Q><N><L><V><P><L> | Putative acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.<BOP> | A0A0U1RQE8 |
O15547 | P2RX6_HUMAN | Purinergic receptor P2X-like 1 | Homo | <M><C><P><Q><L><A><G><A><G><S><M><G><S><P><G><A><T><T><G><W><G><L><L><D><Y><K><T><E><K><Y><V><M><T><R><N><W><R><V><G><A><L><Q><R><L><L><Q><F><G><I><V><V><Y><V><V><G><W><A><L><L><A><K><K><G><Y><Q><E><R><D><L><E><P><Q><F><S><I><I><T><K><L><K><G><V><S><V><T><Q><I><K><E><L><G><N><R><L><W><D><V><A><D><F><V><K><P><P><Q><G><E><N><V><F><F><L><V><T><N><F><L><V><T><P><A><Q><V><Q><G><R><C><P><E><H><P><S><V><P><L><A><N><C><W><V><D><E><D><C><P><E><G><E><G><G><T><H><S><H><G><V><K><T><G><Q><C><V><V><F><N><G><T><H><R><T><C><E><I><W><S><W><C><P><V><E><S><G><V><V><P><S><R><P><L><L><A><Q><A><Q><N><F><T><L><F><I><K><N><T><V><T><F><S><K><F><N><F><S><K><S><N><A><L><E><T><W><D><P><T><Y><F><K><H><C><R><Y><E><P><Q><F><S><P><Y><C><P><V><F><R><I><G><D><L><V><A><K><A><G><G><T><F><E><D><L><A><L><L><G><G><S><V><G><I><R><V><H><W><D><C><D><L><D><T><G><D><S><G><C><W><P><H><Y><S><F><Q><L><Q><E><K><S><Y><N><F><R><T><A><T><H><W><W><E><Q><P><G><V><E><A><R><T><L><L><K><L><Y><G><I><R><F><D><I><L><V><T><G><Q><A><G><K><F><G><L><I><P><T><A><V><T><L><G><T><G><A><A><W><L><G><V><V><T><F><F><C><D><L><L><L><L><Y><V><D><R><E><A><H><F><Y><W><R><T><K><Y><E><E><A><K><A><P><K><A><T><A><N><S><V><W><R><E><L><A><L><A><S><Q><A><R><L><A><E><C><L><R><R><S><S><A><P><A><P><T><A><T><A><A><G><S><Q><T><Q><T><P><G><W><P><C><P><S><S><D><T><H><L><P><T><H><S><G><S><L> | Receptor for ATP that acts as a ligand-gated ion channel.<BOP> | O15547 |
Q96A44 | SPSB4_HUMAN | SPRY domain-containing SOCS box protein 4 | Homo | <M><G><Q><K><L><S><G><S><L><K><S><V><E><V><R><E><P><A><L><R><P><A><K><R><E><L><R><G><A><E><P><G><R><P><A><R><L><D><Q><L><L><D><M><P><A><A><G><L><A><V><Q><L><R><H><A><W><N><P><E><D><R><S><L><N><V><F><V><K><D><D><D><R><L><T><F><H><R><H><P><V><A><Q><S><T><D><G><I><R><G><K><V><G><H><A><R><G><L><H><A><W><Q><I><N><W><P><A><R><Q><R><G><T><H><A><V><V><G><V><A><T><A><R><A><P><L><H><S><V><G><Y><T><A><L><V><G><S><D><A><E><S><W><G><W><D><L><G><R><S><R><L><Y><H><D><G><K><N><Q><P><G><V><A><Y><P><A><F><L><G><P><D><E><A><F><A><L><P><D><S><L><L><V><V><L><D><M><D><E><G><T><L><S><F><I><V><D><G><Q><Y><L><G><V><A><F><R><G><L><K><G><K><K><L><Y><P><V><V><S><A><V><W><G><H><C><E><V><T><M><R><Y><I><N><G><L><D><P><E><P><L><P><L><M><D><L><C><R><R><S><I><R><S><A><L><G><R><Q><R><L><Q><D><I><S><S><L><P><L><P><Q><S><L><K><N><Y><L><Q><Y><Q> | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 . Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 . Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 .<BOP> | Q96A44 |
P14770 | GPIX_HUMAN | Glycoprotein 9 | Homo | <M><P><A><W><G><A><L><F><L><L><W><A><T><A><E><A><T><K><D><C><P><S><P><C><T><C><R><A><L><E><T><M><G><L><W><V><D><C><R><G><H><G><L><T><A><L><P><A><L><P><A><R><T><R><H><L><L><L><A><N><N><S><L><Q><S><V><P><P><G><A><F><D><H><L><P><Q><L><Q><T><L><D><V><T><Q><N><P><W><H><C><D><C><S><L><T><Y><L><R><L><W><L><E><D><R><T><P><E><A><L><L><Q><V><R><C><A><S><P><S><L><A><A><H><G><P><L><G><R><L><T><G><Y><Q><L><G><S><C><G><W><Q><L><Q><A><S><W><V><R><P><G><V><L><W><D><V><A><L><V><A><V><A><A><L><G><L><A><L><L><A><G><L><L><C><A><T><T><E><A><L><D> | The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.<BOP> | P14770 |
O00321 | ETV2_HUMAN | Ets-related protein 71 | Homo | <M><D><L><W><N><W><D><E><A><S><P><Q><E><V><P><P><G><N><K><L><A><G><L><E><G><A><K><L><G><F><C><F><P><D><L><A><L><Q><G><D><T><P><T><A><T><A><E><T><C><W><K><G><T><S><S><S><L><A><S><F><P><Q><L><D><W><G><S><A><L><L><H><P><E><V><P><W><G><A><E><P><D><S><Q><A><L><P><W><S><G><D><W><T><D><M><A><C><T><A><W><D><S><W><S><G><A><S><Q><T><L><G><P><A><P><L><G><P><G><P><I><P><A><A><G><S><E><G><A><A><G><Q><N><C><V><P><V><A><G><E><A><T><S><W><S><R><A><Q><A><A><G><S><N><T><S><W><D><C><S><V><G><P><D><G><D><T><Y><W><G><S><G><L><G><G><E><P><R><T><D><C><T><I><S><W><G><G><P><A><G><P><D><C><T><T><S><W><N><P><G><L><H><A><G><G><T><T><S><L><K><R><Y><Q><S><S><A><L><T><V><C><S><E><P><S><P><Q><S><D><R><A><S><L><A><R><C><P><K><T><N><H><R><G><P><I><Q><L><W><Q><F><L><L><E><L><L><H><D><G><A><R><S><S><C><I><R><W><T><G><N><S><R><E><F><Q><L><C><D><P><K><E><V><A><R><L><W><G><E><R><K><R><K><P><G><M><N><Y><E><K><L><S><R><G><L><R><Y><Y><Y><R><R><D><I><V><R><K><S><G><G><R><K><Y><T><Y><R><F><G><G><R><V><P><S><L><A><Y><P><D><C><A><G><G><G><R><G><A><E><T><Q> | Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.<BOP> | O00321 |
P11226 | MBL2_HUMAN | Mannose-binding lectin | Homo | <M><S><L><F><P><S><L><P><L><L><L><L><S><M><V><A><A><S><Y><S><E><T><V><T><C><E><D><A><Q><K><T><C><P><A><V><I><A><C><S><S><P><G><I><N><G><F><P><G><K><D><G><R><D><G><T><K><G><E><K><G><E><P><G><Q><G><L><R><G><L><Q><G><P><P><G><K><L><G><P><P><G><N><P><G><P><S><G><S><P><G><P><K><G><Q><K><G><D><P><G><K><S><P><D><G><D><S><S><L><A><A><S><E><R><K><A><L><Q><T><E><M><A><R><I><K><K><W><L><T><F><S><L><G><K><Q><V><G><N><K><F><F><L><T><N><G><E><I><M><T><F><E><K><V><K><A><L><C><V><K><F><Q><A><S><V><A><T><P><R><N><A><A><E><N><G><A><I><Q><N><L><I><K><E><E><A><F><L><G><I><T><D><E><K><T><E><G><Q><F><V><D><L><T><G><N><R><L><T><Y><T><N><W><N><E><G><E><P><N><N><A><G><S><D><E><D><C><V><L><L><L><K><N><G><Q><W><N><D><V><P><C><S><T><S><H><L><A><V><C><E><F><P><I> | Calcium-dependent lectin involved in innate immune defense . Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response .<BOP> | P11226 |
Q75WM6 | H1FNT_HUMAN | Histone H1t2 | Homo | <M><E><Q><A><L><T><G><E><A><Q><S><R><W><P><R><R><G><G><S><G><A><M><A><E><A><P><G><P><S><G><E><S><R><G><H><S><A><T><Q><L><P><A><E><K><T><V><G><G><P><S><R><G><C><S><S><S><V><L><R><V><S><Q><L><V><L><Q><A><I><S><T><H><K><G><L><T><L><A><A><L><K><K><E><L><R><N><A><G><Y><E><V><R><R><K><S><G><R><H><E><A><P><R><G><Q><A><K><A><T><L><L><R><V><S><G><S><D><A><A><G><Y><F><R><V><W><K><V><P><K><P><R><R><K><P><G><R><A><R><Q><E><E><G><T><R><A><P><W><R><T><P><A><A><P><R><S><S><R><R><R><R><Q><P><L><R><K><A><A><R><K><A><R><E><V><W><R><R><N><A><R><A><K><A><K><A><N><A><R><A><R><R><T><R><R><A><R><P><R><A><K><E><P><P><C><A><R><A><K><E><E><A><G><A><T><A><A><D><E><G><R><G><Q><A><V><K><E><D><T><T><P><R><S><G><K><D><K><R><R><S><S><K><P><R><E><E><K><Q><E><P><K><K><P><A><Q><R><T><I><Q> | Essential for normal spermatogenesis and male fertility . Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1.<BOP> | Q75WM6 |
O60443 | GSDME_HUMAN | Gasdermin-E, C-terminal | Homo | <M><F><A><K><A><T><R><N><F><L><R><E><V><D><A><D><G><D><L><I><A><V><S><N><L><N><D><S><D><K><L><Q><L><L><S><L><V><T><K><K><K><R><F><W><C><W><Q><R><P><K><Y><Q><F><L><S><L><T><L><G><D><V><L><I><E><D><Q><F><P><S><P><V><V><V><E><S><D><F><V><K><Y><E><G><K><F><A><N><H><V><S><G><T><L><E><T><A><L><G><K><V><K><L><N><L><G><G><S><S><R><V><E><S><Q><S><S><F><G><T><L><R><K><Q><E><V><D><L><Q><Q><L><I><R><D><S><A><E><R><T><I><N><L><R><N><P><V><L><Q><Q><V><L><E><G><R><N><E><V><L><C><V><L><T><Q><K><I><T><T><M><Q><K><C><V><I><S><E><H><M><Q><V><E><E><K><C><G><G><I><V><G><I><Q><T><K><T><V><Q><V><S><A><T><E><D><G><N><V><T><K><D><S><N><V><V><L><E><I><P><A><A><T><T><I><A><Y><G><V><I><E><L><Y><V><K><L><D><G><Q><F><E><F><C><L><L><R><G><K><Q><G><G><F><E><N><K><K><R><I><D><S><V><Y><L><D><P><L><V><F><R><E><F><A><F><I><D><M><P><D><A><A><H><G><I><S><S><Q><D><G><P><L><S><V><L><K><Q><A><T><L><L><L><E><R><N><F><H><P><F><A><E><L><P><E><P><Q><Q><T><A><L><S><D><I><F><Q><A><V><L><F><D><D><E><L><L><M><V><L><E><P><V><C><D><D><L><V><S><G><L><S><P><T><V><A><V><L><G><E><L><K><P><R><Q><Q><Q><D><L><V><A><F><L><Q><L><V><G><C><S><L><Q><G><G><C><P><G><P><E><D><A><G><S><K><Q><L><F><M><T><A><Y><F><L><V><S><A><L><A><E><M><P><D><S><A><A><A><L><L><G><T><C><C><K><L><Q><I><I><P><T><L><C><H><L><L><R><A><L><S><D><D><G><V><S><D><L><E><D><P><T><L><T><P><L><K><D><T><E><R><F><G><I><V><Q><R><L><F><A><S><A><D><I><S><L><E><R><L><K><S><S><V><K><A><V><I><L><K><D><S><K><V><F><P><L><L><L><C><I><T><L><N><G><L><C><A><L><G><R><E><H><S> | Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively . After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis . Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate . Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis . Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents . Exhibits bactericidal activity . Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity . Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, | O60443 |
Q96MM7 | H6ST2_HUMAN | Heparan-sulfate 6-O-sulfotransferase 2 | Homo | <M><A><L><P><A><C><A><V><R><E><F><E><P><P><R><Q><P><E><R><G><A><P><V><R><T><T><C><P><R><R><H><S><R><V><E><A><E><L><A><A><S><R><P><G><S><V><A><A><S><V><R><A><G><P><P><R><G><V><S><H><G><F><H><T><R><P><L><L><D><K><P><R><K><A><S><S><S><L><A><G><A><A><C><A><P><L><F><A><L><L><S><R><G><R><R><R><R><M><H><V><L><R><R><R><W><D><L><G><S><L><C><R><A><L><L><T><R><G><L><A><A><L><G><H><S><L><K><H><V><L><G><A><I><F><S><K><I><F><G><P><M><A><S><V><G><N><M><D><E><K><S><N><K><L><L><L><A><L><V><M><L><F><L><F><A><V><I><V><L><Q><Y><V><C><P><G><T><E><C><Q><L><L><R><L><Q><A><F><S><S><P><V><P><D><P><Y><R><S><E><D><E><S><S><A><R><F><V><P><R><Y><N><F><T><R><G><D><L><L><R><K><V><D><F><D><I><K><G><D><D><L><I><V><F><L><H><I><Q><K><T><G><G><T><T><F><G><R><H><L><V><R><N><I><Q><L><E><Q><P><C><E><C><R><V><G><Q><K><K><C><T><C><H><R><P><G><K><R><E><T><W><L><F><S><R><F><S><T><G><W><S><C><G><L><H><A><D><W><T><E><L><T><S><C><V><P><S><V><V><D><G><K><R><D><A><R><L><R><P><S><R><N><F><H><Y><I><T><I><L><R><D><P><V><S><R><Y><L><S><E><W><R><H><V><Q><R><G><A><T><W><K><A><S><L><H><V><C><D><G><R><P><P><T><S><E><E><L><P><S><C><Y><T><G><D><D><W><S><G><C><P><L><K><E><F><M><D><C><P><Y><N><L><A><N><N><R><Q><V><R><M><L><S><D><L><T><L><V><G><C><Y><N><L><S><V><M><P><E><K><Q><R><N><K><V><L><L><E><S><A><K><S><N><L><K><H><M><A><F><F><G><L><T><E><F><Q><R><K><T><Q><Y><L><F><E><K><T><F><N><M><N><F><I><S><P><F><T><Q><Y><N><T><T><R><A><S><S><V><E><I><N><E><E><I><Q><K><R><I><E><G><L><N><F><L><D><M><E><L><Y><S><Y><A><K><D><L><F><L><Q><R><Y><Q><F><M><R><Q><K><E><H><Q><E><A><R><R><K><R><Q><E><Q><R><K><F><L><K><G><R><L><L><Q><T><H><F><Q><S><Q><G><Q><G><Q><S><Q><N><P><N><Q><N><Q><S><Q><N><P><N><P><N><A><N><Q><N><L><T><Q><N><L><M><Q><N><L><T><Q><S><L><S><Q><K><E><N><R><E><S><P><K><Q><N><S><G><K><E><Q><N><D><N><T><S><N><G><T><N><D><Y><I><G><S><V><E><K><W><R> | 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.<BOP> | Q96MM7 |
O60404 | O10H3_HUMAN | Olfactory receptor OR19-24 | Homo | <M><P><G><Q><N><Y><R><T><I><S><E><F><I><L><S><G><F><S><A><F><P><Q><Q><L><L><P><V><L><F><L><L><Y><L><L><M><F><L><F><T><L><L><G><N><L><L><I><M><A><T><V><W><I><E><R><R><L><H><T><P><M><Y><L><F><L><C><A><L><S><I><S><E><I><L><F><T><V><A><I><T><P><R><M><L><A><D><L><L><F><T><H><R><S><I><T><F><V><A><C><A><I><Q><M><F><F><S><F><M><F><G><F><T><H><S><F><L><L><M><V><M><G><Y><D><H><Y><V><T><I><C><H><P><L><H><Y><N><M><L><M><S><P><R><G><C><A><H><L><V><A><W><T><W><A><G><G><S><V><M><G><M><M><V><T><M><M><V><F><H><L><T><F><C><G><S><N><V><I><H><H><F><L><C><H><V><L><S><L><L><K><L><A><C><G><S><K><T><S><S><V><I><M><G><V><M><L><V><C><V><T><A><L><I><G><C><L><F><L><I><I><L><S><F><V><F><I><V><A><A><I><L><R><I><P><S><A><E><G><R><H><K><T><F><S><T><C><V><S><H><L><T><V><V><V><M><H><Y><S><F><A><S><L><I><Y><L><K><P><K><G><L><H><S><M><Y><S><D><A><L><M><A><T><T><Y><T><V><F><T><P><F><L><S><P><I><I><F><S><L><R><N><K><E><L><K><N><A><I><N><K><N><F><C><R><R><F><C><P><L><S><S> | Odorant receptor.<BOP> | O60404 |
P06729 | CD2_HUMAN | T-cell surface antigen T11/Leu-5 | Homo | <M><S><F><P><C><K><F><V><A><S><F><L><L><I><F><N><V><S><S><K><G><A><V><S><K><E><I><T><N><A><L><E><T><W><G><A><L><G><Q><D><I><N><L><D><I><P><S><F><Q><M><S><D><D><I><D><D><I><K><W><E><K><T><S><D><K><K><K><I><A><Q><F><R><K><E><K><E><T><F><K><E><K><D><T><Y><K><L><F><K><N><G><T><L><K><I><K><H><L><K><T><D><D><Q><D><I><Y><K><V><S><I><Y><D><T><K><G><K><N><V><L><E><K><I><F><D><L><K><I><Q><E><R><V><S><K><P><K><I><S><W><T><C><I><N><T><T><L><T><C><E><V><M><N><G><T><D><P><E><L><N><L><Y><Q><D><G><K><H><L><K><L><S><Q><R><V><I><T><H><K><W><T><T><S><L><S><A><K><F><K><C><T><A><G><N><K><V><S><K><E><S><S><V><E><P><V><S><C><P><E><K><G><L><D><I><Y><L><I><I><G><I><C><G><G><G><S><L><L><M><V><F><V><A><L><L><V><F><Y><I><T><K><R><K><K><Q><R><S><R><R><N><D><E><E><L><E><T><R><A><H><R><V><A><T><E><E><R><G><R><K><P><H><Q><I><P><A><S><T><P><Q><N><P><A><T><S><Q><H><P><P><P><P><P><G><H><R><S><Q><A><P><S><H><R><P><P><P><P><G><H><R><V><Q><H><Q><P><Q><K><R><P><P><A><P><S><G><T><Q><V><H><Q><Q><K><G><P><P><L><P><R><P><R><V><Q><P><K><P><P><H><G><A><A><E><N><S><L><S><P><S><S><N> | CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.<BOP> | P06729 |
Q2M3W8 | ZN181_HUMAN | HHZ181 | Homo | <M><P><Q><V><T><F><N><D><V><A><I><D><F><T><H><E><E><W><G><W><L><S><S><A><Q><R><D><L><Y><K><D><V><M><V><Q><N><Y><E><N><L><V><S><V><A><G><L><S><V><T><K><P><Y><V><I><T><L><L><E><D><G><K><E><P><W><M><M><E><K><K><L><S><K><G><M><I><P><D><W><E><S><R><W><E><N><K><E><L><S><T><K><K><D><N><Y><D><E><D><S><P><Q><T><V><I><I><E><K><V><V><K><Q><S><Y><E><F><S><N><S><K><K><N><L><E><Y><I><E><K><L><E><G><K><H><G><S><Q><V><D><H><F><R><P><A><I><L><T><S><R><E><S><P><T><A><D><S><V><Y><K><Y><N><I><F><R><S><T><F><H><S><K><S><T><L><S><E><P><Q><K><I><S><A><E><G><N><S><H><K><Y><D><I><L><K><K><N><L><P><K><K><S><V><I><K><N><E><K><V><N><G><G><K><K><L><L><N><S><N><K><S><G><A><A><F><S><Q><G><K><S><L><T><L><P><Q><T><C><N><R><E><K><I><Y><T><C><S><E><C><G><K><A><F><G><K><Q><S><I><L><N><R><H><W><R><I><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><T><F><S><H><G><S><S><L><T><R><H><L><I><S><H><S><G><E><K><P><Y><K><C><I><E><C><G><K><A><F><S><H><V><S><S><L><T><N><H><Q><S><T><H><T><G><E><K><P><Y><E><C><M><N><C><G><K><S><F><S><R><V><S><H><L><I><E><H><L><R><I><H><T><Q><E><K><L><Y><E><C><R><I><C><G><K><A><F><I><H><R><S><S><L><I><H><H><Q><K><I><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><A><F><C><C><S><S><H><L><T><R><H><Q><R><I><H><T><M><E><K><Q><Y><E><C><N><K><C><L><K><V><F><S><S><L><S><F><L><V><Q><H><Q><S><I><H><T><E><E><K><P><F><E><C><Q><K><C><R><K><S><F><N><Q><L><E><S><L><N><M><H><L><R><N><H><I><R><L><K><P><Y><E><C><S><I><C><G><K><A><F><S><H><R><S><S><L><L><Q><H><H><R><I><H><T><G><E><K><P><Y><E><C><I><K><C><G><K><T><F><S><C><S><S><N><L><T><V><H><Q><R><I><H><T><G><E><K><P><Y><K><C><N><E><C><G><K><A><F><S><K><G><S><N><L><T><A><H><Q><R><V><H><N><G><E><K><P><N><S><V><V><S><V><E><K><P><L><D><Y><M><N><H><Y><T><C><E><K><S><Y><R><R><E><T><V> | May be involved in transcriptional regulation.<BOP> | Q2M3W8 |
Q7Z6Z6 | PLPL5_HUMAN | GS2-like protein | Homo | <M><G><F><L><E><E><E><G><R><W><N><L><S><F><S><G><A><G><Y><L><G><A><H><H><V><G><A><T><E><C><L><R><Q><R><A><P><R><L><L><Q><G><A><R><R><I><Y><G><S><S><S><G><A><L><N><A><V><S><I><V><C><G><K><S><V><D><F><C><C><S><H><L><L><G><M><V><G><Q><L><E><R><L><S><L><S><I><L><H><P><A><Y><A><P><I><E><H><V><K><Q><Q><L><Q><D><A><L><P><P><D><A><H><V><L><A><S><Q><R><L><G><I><S><L><T><R><W><P><D><G><R><N><F><L><V><T><D><F><A><T><C><D><E><L><I><Q><A><L><V><C><T><L><Y><F><P><F><Y><C><G><L><I><P><P><E><F><R><G><E><R><Y><I><D><G><A><L><S><N><N><L><P><F><A><D><C><P><S><T><I><T><V><S><P><F><H><G><T><V><D><I><C><P><Q><S><T><S><P><N><L><H><E><L><N><V><F><N><F><S><F><Q><I><S><T><E><N><F><F><L><G><L><I><C><L><I><P><P><S><L><E><V><V><A><D><N><C><R><Q><G><Y><L><D><A><L><R><F><L><E><R><R><G><L><T><K><E><P><V><L><W><T><L><V><S><K><E><P><P><A><P><A><D><G><N><W><D><A><G><C><D><Q><R><W><K><G><G><L><S><L><N><W><K><V><P><H><V><Q><V><K><D><V><P><N><F><E><Q><L><S><P><E><L><E><A><A><L><K><K><A><C><T><R><D><P><S><R><W><A><R><F><W><H><S><G><P><G><Q><V><L><T><Y><L><L><L><P><C><T><L><P><F><E><Y><I><Y><F><R><S><R><R><L><V><V><W><L><P><D><V><P><A><D><L><W><W><M><Q><G><L><L><R><N><M><A><L><E><V><F><S><R><T><K><A><Q><L><L><G><P><I><S><P><P><A><T><R><V><L><E><T><S><P><L><Q><P><Q><I><A><P><H><R><E><E><L><G><P><T><H><Q><A> | Has abundant triacylglycerol lipase activity.<BOP> | Q7Z6Z6 |
P39687 | AN32A_HUMAN | Putative HLA-DR-associated protein I | Homo | <M><E><M><G><R><R><I><H><L><E><L><R><N><R><T><P><S><D><V><K><E><L><V><L><D><N><S><R><S><N><E><G><K><L><E><G><L><T><D><E><F><E><E><L><E><F><L><S><T><I><N><V><G><L><T><S><I><A><N><L><P><K><L><N><K><L><K><K><L><E><L><S><D><N><R><V><S><G><G><L><E><V><L><A><E><K><C><P><N><L><T><H><L><N><L><S><G><N><K><I><K><D><L><S><T><I><E><P><L><K><K><L><E><N><L><K><S><L><D><L><F><N><C><E><V><T><N><L><N><D><Y><R><E><N><V><F><K><L><L><P><Q><L><T><Y><L><D><G><Y><D><R><D><D><K><E><A><P><D><S><D><A><E><G><Y><V><E><G><L><D><D><E><E><E><D><E><D><E><E><E><Y><D><E><D><A><Q><V><V><E><D><E><E><D><E><D><E><E><E><E><G><E><E><E><D><V><S><G><E><E><E><E><D><E><E><G><Y><N><D><G><E><V><D><D><E><E><D><E><E><E><L><G><E><E><E><R><G><Q><K><R><K><R><E><P><E><D><E><G><E><D><D><D> | (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication . Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region . Also plays an essential role in foamy virus mRNA export from the nucleus .<BOP> | P39687 |
A0A0A6YYK4 | TVB71_HUMAN | Probable non-functional T cell receptor beta variable 7-1 | Homo | <M><G><T><R><L><L><C><W><A><A><I><C><L><L><G><A><D><H><T><G><A><G><V><S><Q><S><L><R><H><K><V><A><K><K><G><K><D><V><A><L><R><Y><D><P><I><S><G><H><N><A><L><Y><W><Y><R><Q><S><L><G><Q><G><L><E><F><P><I><Y><F><Q><G><K><D><A><A><D><K><S><G><L><P><R><D><R><F><S><A><Q><R><S><E><G><S><I><S><T><L><K><F><Q><R><T><Q><Q><G><D><L><A><V><Y><L><C><A><S><S><S> | Probable non-functional open reading frame (ORF) of V region of the variable domain of T cell receptor (TR) beta chain . Non-functional ORF generally cannot participate in the synthesis of a productive T cell receptor (TR) chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK | A0A0A6YYK4 |
Q15293 | RCN1_HUMAN | Reticulocalbin-1 | Homo | <M><A><R><G><G><R><G><R><R><L><G><L><A><L><G><L><L><L><A><L><V><L><A><P><R><V><L><R><A><K><P><T><V><R><K><E><R><V><V><R><P><D><S><E><L><G><E><R><P><P><E><D><N><Q><S><F><Q><Y><D><H><E><A><F><L><G><K><E><D><S><K><T><F><D><Q><L><T><P><D><E><S><K><E><R><L><G><K><I><V><D><R><I><D><N><D><G><D><G><F><V><T><T><E><E><L><K><T><W><I><K><R><V><Q><K><R><Y><I><F><D><N><V><A><K><V><W><K><D><Y><D><R><D><K><D><D><K><I><S><W><E><E><Y><K><Q><A><T><Y><G><Y><Y><L><G><N><P><A><E><F><H><D><S><S><D><H><H><T><F><K><K><M><L><P><R><D><E><R><R><F><K><A><A><D><L><N><G><D><L><T><A><T><R><E><E><F><T><A><F><L><H><P><E><E><F><E><H><M><K><E><I><V><V><L><E><T><L><E><D><I><D><K><N><G><D><G><F><V><D><Q><D><E><Y><I><A><D><M><F><S><H><E><E><N><G><P><E><P><D><W><V><L><S><E><R><E><Q><F><N><E><F><R><D><L><N><K><D><G><K><L><D><K><D><E><I><R><H><W><I><L><P><Q><D><Y><D><H><A><Q><A><E><A><R><H><L><V><Y><E><S><D><K><N><K><D><E><K><L><T><K><E><E><I><L><E><N><W><N><M><F><V><G><S><Q><A><T><N><Y><G><E><D><L><T><K><N><H><D><E><L> | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.<BOP> | Q15293 |
Q9NQE7 | TSSP_HUMAN | Serine protease 16 | Homo | <M><A><V><W><L><A><Q><W><L><G><P><L><L><L><V><S><L><W><G><L><L><A><P><A><S><L><L><R><R><L><G><E><H><I><Q><Q><F><Q><E><S><S><A><Q><G><L><G><L><S><L><G><P><G><A><A><A><L><P><K><V><G><W><L><E><Q><L><L><D><P><F><N><V><S><D><R><R><S><F><L><Q><R><Y><W><V><N><D><Q><H><W><V><G><Q><D><G><P><I><F><L><H><L><G><G><E><G><S><L><G><P><G><S><V><M><R><G><H><P><A><A><L><A><P><A><W><G><A><L><V><I><S><L><E><H><R><F><Y><G><L><S><I><P><A><G><G><L><E><M><A><Q><L><R><F><L><S><S><R><L><A><L><A><D><V><V><S><A><R><L><A><L><S><R><L><F><N><I><S><S><S><S><P><W><I><C><F><G><G><S><Y><A><G><S><L><A><A><W><A><R><L><K><F><P><H><L><I><F><A><S><V><A><S><S><A><P><V><R><A><V><L><D><F><S><E><Y><N><D><V><V><S><R><S><L><M><S><T><A><I><G><G><S><L><E><C><R><A><A><V><S><V><A><F><A><E><V><E><R><R><L><R><S><G><G><A><A><Q><A><A><L><R><T><E><L><S><A><C><G><P><L><G><R><A><E><N><Q><A><E><L><L><G><A><L><Q><A><L><V><G><G><V><V><Q><Y><D><G><Q><T><G><A><P><L><S><V><R><Q><L><C><G><L><L><L><G><G><G><G><N><R><S><H><S><T><P><Y><C><G><L><R><R><A><V><Q><I><V><L><H><S><L><G><Q><K><C><L><S><F><S><R><A><E><T><V><A><Q><L><R><S><T><E><P><Q><L><S><G><V><G><D><R><Q><W><L><Y><Q><T><C><T><E><F><G><F><Y><V><T><C><E><N><P><R><C><P><F><S><Q><L><P><A><L><P><S><Q><L><D><L><C><E><Q><V><F><G><L><S><A><L><S><V><A><Q><A><V><A><Q><T><N><S><Y><Y><G><G><Q><T><P><G><A><N><K><V><L><F><V><N><G><D><T><D><P><W><H><V><L><S><V><T><Q><A><L><G><S><S><E><S><T><L><L><I><R><T><G><S><H><C><L><D><M><A><P><E><R><P><S><D><S><P><S><L><R><L><G><R><Q><N><I><F><Q><Q><L><Q><T><W><L><K><L><A><K><E><S><Q><I><K><G><E><V> | Protease that may play a role in T-cell development.<BOP> | Q9NQE7 |
P10092 | CALCB_HUMAN | Calcitonin gene-related peptide II | Homo | <M><G><F><R><K><F><S><P><F><L><A><L><S><I><L><V><L><Y><Q><A><G><S><L><Q><A><A><P><F><R><S><A><L><E><S><S><P><D><P><A><T><L><S><K><E><D><A><R><L><L><L><A><A><L><V><Q><D><Y><V><Q><M><K><A><S><E><L><K><Q><E><Q><E><T><Q><G><S><S><S><A><A><Q><K><R><A><C><N><T><A><T><C><V><T><H><R><L><A><G><L><L><S><R><S><G><G><M><V><K><S><N><F><V><P><T><N><V><G><S><K><A><F><G><R><R><R><R><D><L><Q><A> | CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.<BOP> | P10092 |
P61581 | NP24_HUMAN | HERV-K_22q11.21 provirus Np9 protein | Homo | <M><N><P><S><E><M><Q><R><K><G><P><P><R><R><W><C><L><Q><V><Y><P><T><A><P><K><R><Q><R><P><S><R><T><G><H><D><D><D><G><G><F><V><E><K><K><R><G><K><C><G><E><K><Q><E><R><S><D><C><Y><C><V><C><V><E><R><S><R><H><R><R><L><H><F><V><M><C> | May possess a function in tumorigenesis.<BOP> | P61581 |
A6NFD8 | HELT_HUMAN | HES/HEY-like transcription factor | Homo | <M><S><D><K><L><K><E><R><K><R><T><P><V><S><H><K><V><I><E><K><R><R><R><D><R><I><N><R><C><L><N><E><L><G><K><T><V><P><M><A><L><A><K><Q><S><S><G><K><L><E><K><A><E><I><L><E><M><T><V><Q><Y><L><R><A><L><H><S><A><D><F><P><R><G><R><E><K><A><E><L><L><A><E><F><A><N><Y><F><H><Y><G><Y><H><E><C><M><K><N><L><V><H><Y><L><T><T><V><E><R><M><E><T><K><D><T><K><Y><A><R><I><L><A><F><L><Q><S><K><A><R><L><G><A><E><P><A><F><P><P><L><G><S><L><P><E><P><D><F><S><Y><Q><L><H><P><A><G><P><E><F><A><G><H><S><P><G><E><A><A><V><F><P><Q><G><S><G><A><G><P><F><P><W><P><P><G><A><A><R><S><P><A><L><P><Y><L><P><S><A><P><V><P><L><A><S><P><A><Q><Q><H><S><P><F><L><T><P><V><Q><G><L><D><R><H><Y><L><N><L><I><G><H><A><H><P><N><A><L><N><L><H><T><P><Q><H><P><P><V><L> | Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'.<BOP> | A6NFD8 |
Q86Y46 | K2C73_HUMAN | Type-II keratin Kb36 | Homo | <M><S><R><Q><F><T><Y><K><S><G><A><A><A><K><G><G><F><S><G><C><S><A><V><L><S><G><G><S><S><S><S><Y><R><A><G><G><K><G><L><S><G><G><F><S><S><R><S><L><Y><S><L><G><G><A><R><S><I><S><F><N><V><A><S><G><S><G><W><A><G><G><Y><G><F><G><R><G><R><A><S><G><F><A><G><S><M><F><G><S><V><A><L><G><S><V><C><P><S><L><C><P><P><G><G><I><H><Q><V><T><I><N><K><S><L><L><A><P><L><N><V><E><L><D><P><E><I><Q><K><V><R><A><Q><E><R><E><Q><I><K><V><L><N><N><K><F><A><S><F><I><D><K><V><R><F><L><E><Q><Q><N><Q><V><L><E><T><K><W><E><L><L><Q><Q><L><D><L><N><N><C><K><N><N><L><E><P><I><L><E><G><Y><I><S><N><L><R><K><Q><L><E><T><L><S><G><D><R><V><R><L><D><S><E><L><R><S><V><R><E><V><V><E><D><Y><K><K><R><Y><E><E><E><I><N><K><R><T><T><A><E><N><E><F><V><V><L><K><K><D><V><D><A><A><Y><T><S><K><V><E><L><Q><A><K><V><D><A><L><D><G><E><I><K><F><F><K><C><L><Y><E><G><E><T><A><Q><I><Q><S><H><I><S><D><T><S><I><I><L><S><M><D><N><N><R><N><L><D><L><D><S><I><I><A><E><V><R><A><Q><Y><E><E><I><A><R><K><S><K><A><E><A><E><A><L><Y><Q><T><K><F><Q><E><L><Q><L><A><A><G><R><H><G><D><D><L><K><H><T><K><N><E><I><S><E><L><T><R><L><I><Q><R><L><R><S><E><I><E><S><V><K><K><Q><C><A><N><L><E><T><A><I><A><D><A><E><Q><R><G><D><C><A><L><K><D><A><R><A><K><L><D><E><L><E><G><A><L><Q><Q><A><K><E><E><L><A><R><M><L><R><E><Y><Q><E><L><L><S><V><K><L><S><L><D><I><E><I><A><T><Y><R><K><L><L><E><G><E><E><C><R><M><S><G><E><Y><T><N><S><V><S><I><S><V><I><N><S><S><M><A><G><M><A><G><T><G><A><G><F><G><F><S><N><A><G><T><Y><G><Y><W><P><S><S><V><S><G><G><Y><S><M><L><P><G><G><C><V><T><G><S><G><N><C><S><P><R><G><E><A><R><T><R><L><G><S><A><S><E><F><R><D><S><Q><G><K><T><L><A><L><S><S><P><T><K><K><T><M><R> | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).<BOP> | Q86Y46 |
Q92963 | RIT1_HUMAN | Ras-like without CAAX protein 1 | Homo | <M><D><S><G><T><R><P><V><G><S><C><C><S><S><P><A><G><L><S><R><E><Y><K><L><V><M><L><G><A><G><G><V><G><K><S><A><M><T><M><Q><F><I><S><H><R><F><P><E><D><H><D><P><T><I><E><D><A><Y><K><I><R><I><R><I><D><D><E><P><A><N><L><D><I><L><D><T><A><G><Q><A><E><F><T><A><M><R><D><Q><Y><M><R><A><G><E><G><F><I><I><C><Y><S><I><T><D><R><R><S><F><H><E><V><R><E><F><K><Q><L><I><Y><R><V><R><R><T><D><D><T><P><V><V><L><V><G><N><K><S><D><L><K><Q><L><R><Q><V><T><K><E><E><G><L><A><L><A><R><E><F><S><C><P><F><F><E><T><S><A><A><Y><R><Y><Y><I><D><D><V><F><H><A><L><V><R><E><I><R><R><K><E><K><E><A><V><L><A><M><E><K><K><S><K><P><K><N><S><V><W><K><R><L><K><S><P><F><R><K><K><K><D><S><V><T> | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<BOP> | Q92963 |
Q9H346 | O52D1_HUMAN | null | Homo | <M><S><D><S><N><L><S><D><N><H><L><P><D><T><F><F><L><T><G><I><P><G><L><E><A><A><H><F><W><I><A><I><P><F><C><A><M><Y><L><V><A><L><V><G><N><A><A><L><I><L><V><I><A><M><D><N><A><L><H><A><P><M><Y><L><F><L><C><L><L><S><L><T><D><L><A><L><S><S><T><T><V><P><K><M><L><A><I><L><W><L><H><A><G><E><I><S><F><G><G><C><L><A><Q><M><F><C><V><H><S><I><Y><A><L><E><S><S><I><L><L><A><M><A><F><D><R><Y><V><A><I><C><N><P><L><R><Y><T><T><I><L><N><H><A><V><I><G><R><I><G><F><V><G><L><F><R><S><V><A><I><V><S><P><F><I><F><L><L><R><R><L><P><Y><C><G><H><R><V><M><T><H><T><Y><C><E><H><M><G><I><A><R><L><A><C><A><N><I><T><V><N><I><V><Y><G><L><T><V><A><L><L><A><M><G><L><D><S><I><L><I><A><I><S><Y><G><F><I><L><H><A><V><F><H><L><P><S><H><D><A><Q><H><K><A><L><S><T><C><G><S><H><I><G><I><I><L><V><F><Y><I><P><A><F><F><S><F><L><T><H><R><F><G><H><H><E><V><P><K><H><V><H><I><F><L><A><N><L><Y><V><L><V><P><P><V><L><N><P><I><L><Y><G><A><R><T><K><E><I><R><S><R><L><L><K><L><L><H><L><G><K><T><S><I> | Odorant receptor.<BOP> | Q9H346 |
Q6HA08 | ASTL_HUMAN | ZP2-proteinase | Homo | <M><E><G><V><G><G><L><W><P><W><V><L><G><L><L><S><L><P><G><V><I><L><G><A><P><L><A><S><S><C><A><G><A><C><G><T><S><F><P><D><G><L><T><P><E><G><T><Q><A><S><G><D><K><D><I><P><A><I><N><Q><G><L><I><L><E><E><T><P><E><S><S><F><L><I><E><G><D><I><I><R><P><S><P><F><R><L><L><S><A><T><S><N><K><W><P><M><G><G><S><G><V><V><E><V><P><F><L><L><S><S><K><Y><D><E><P><S><R><Q><V><I><L><E><A><L><A><E><F><E><R><S><T><C><I><R><F><V><T><Y><Q><D><Q><R><D><F><I><S><I><I><P><M><Y><G><C><F><S><S><V><G><R><S><G><G><M><Q><V><V><S><L><A><P><T><C><L><Q><K><G><R><G><I><V><L><H><E><L><M><H><V><L><G><F><W><H><E><H><T><R><A><D><R><D><R><Y><I><R><V><N><W><N><E><I><L><P><G><F><E><I><N><F><I><K><S><Q><S><S><N><M><L><T><P><Y><D><Y><S><S><V><M><H><Y><G><R><L><A><F><S><R><R><G><L><P><T><I><T><P><L><W><A><P><S><V><H><I><G><Q><R><W><N><L><S><A><S><D><I><T><R><V><L><K><L><Y><G><C><S><P><S><G><P><R><P><R><G><R><G><S><H><A><H><S><T><G><R><S><P><A><P><A><S><L><S><L><Q><R><L><L><E><A><L><S><A><E><S><R><S><P><D><P><S><G><S><S><A><G><G><Q><P><V><P><A><G><P><G><E><S><P><H><G><W><E><S><P><A><L><K><K><L><S><A><E><A><S><A><R><Q><P><Q><T><L><A><S><S><P><R><S><R><P><G><A><G><A><P><G><V><A><Q><E><Q><S><W><L><A><G><V><S><T><K><P><T><V><P><S><S><E><A><G><I><Q><P><V><P><V><Q><G><S><P><A><L><P><G><G><C><V><P><R><N><H><F><K><G><M><S><E><D> | Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.<BOP> | Q6HA08 |
Q86SR1 | GLT10_HUMAN | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 | Homo | <M><R><R><K><E><K><R><L><L><Q><A><V><A><L><V><L><A><A><L><V><L><L><P><N><V><G><L><W><A><L><Y><R><E><R><Q><P><D><G><T><P><G><G><S><G><A><A><V><A><P><A><A><G><Q><G><S><H><S><R><Q><K><K><T><F><F><L><G><D><G><Q><K><L><K><D><W><H><D><K><E><A><I><R><R><D><A><Q><R><V><G><N><G><E><Q><G><R><P><Y><P><M><T><D><A><E><R><V><D><Q><A><Y><R><E><N><G><F><N><I><Y><V><S><D><K><I><S><L><N><R><S><L><P><D><I><R><H><P><N><C><N><S><K><R><Y><L><E><T><L><P><N><T><S><I><I><I><P><F><H><N><E><G><W><S><S><L><L><R><T><V><H><S><V><L><N><R><S><P><P><E><L><V><A><E><I><V><L><V><D><D><F><S><D><R><E><H><L><K><K><P><L><E><D><Y><M><A><L><F><P><S><V><R><I><L><R><T><K><K><R><E><G><L><I><R><T><R><M><L><G><A><S><V><A><T><G><D><V><I><T><F><L><D><S><H><C><E><A><N><V><N><W><L><P><P><L><L><D><R><I><A><R><N><R><K><T><I><V><C><P><M><I><D><V><I><D><H><D><D><F><R><Y><E><T><Q><A><G><D><A><M><R><G><A><F><D><W><E><M><Y><Y><K><R><I><P><I><P><P><E><L><Q><K><A><D><P><S><D><P><F><E><S><P><V><M><A><G><G><L><F><A><V><D><R><K><W><F><W><E><L><G><G><Y><D><P><G><L><E><I><W><G><G><E><Q><Y><E><I><S><F><K><V><W><M><C><G><G><R><M><E><D><I><P><C><S><R><V><G><H><I><Y><R><K><Y><V><P><Y><K><V><P><A><G><V><S><L><A><R><N><L><K><R><V><A><E><V><W><M><D><E><Y><A><E><Y><I><Y><Q><R><R><P><E><Y><R><H><L><S><A><G><D><V><A><V><Q><K><K><L><R><S><S><L><N><C><K><S><F><K><W><F><M><T><K><I><A><W><D><L><P><K><F><Y><P><P><V><E><P><P><A><A><A><W><G><E><I><R><N><V><G><T><G><L><C><A><D><T><K><H><G><A><L><G><S><P><L><R><L><E><G><C><V><R><G><R><G><E><A><A><W><N><N><M><Q><V><F><T><F><T><W><R><E><D><I><R><P><G><D><P><Q><H><T><K><K><F><C><F><D><A><I><S><H><T><S><P><V><T><L><Y><D><C><H><S><M><K><G><N><Q><L><W><K><Y><R><K><D><K><T><L><Y><H><P><V><S><G><S><C><M><D><C><S><E><S><D><H><R><I><F><M><N><T><C><N><P><S><S><L><T><Q><Q><W><L><F><E><H><T><N><S><T><V><L><E><K><F><N><R><N> | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.<BOP> | Q86SR1 |
Q9NY61 | AATF_HUMAN | Rb-binding protein Che-1 | Homo | <M><A><G><P><Q><P><L><A><L><Q><L><E><Q><L><L><N><P><R><P><S><E><A><D><P><E><A><D><P><E><E><A><T><A><A><R><V><I><D><R><F><D><E><G><E><D><G><E><G><D><F><L><V><V><G><S><I><R><K><L><A><S><A><S><L><L><D><T><D><K><R><Y><C><G><K><T><T><S><R><K><A><W><N><E><D><H><W><E><Q><T><L><P><G><S><S><D><E><E><I><S><D><E><E><G><S><G><D><E><D><S><E><G><L><G><L><E><E><Y><D><E><D><D><L><G><A><A><E><E><Q><E><C><G><D><H><R><E><S><K><K><S><R><S><H><S><A><K><T><P><G><F><S><V><Q><S><I><S><D><F><E><K><F><T><K><G><M><D><D><L><G><S><S><E><E><E><E><D><E><E><S><G><M><E><E><G><D><D><A><E><D><S><Q><G><E><S><E><E><D><R><A><G><D><R><N><S><E><D><D><G><V><V><M><T><F><S><S><V><K><V><S><E><E><V><E><K><G><R><A><V><K><N><Q><I><A><L><W><D><Q><L><L><E><G><R><I><K><L><Q><K><A><L><L><T><T><N><Q><L><P><Q><P><D><V><F><P><L><F><K><D><K><G><G><P><E><F><S><S><A><L><K><N><S><H><K><A><L><K><A><L><L><R><S><L><V><G><L><Q><E><E><L><L><F><Q><Y><P><D><T><R><Y><L><V><D><G><T><K><P><N><A><G><S><E><E><I><S><S><E><D><D><E><L><V><E><E><K><K><Q><Q><R><R><R><V><P><A><K><R><K><L><E><M><E><D><Y><P><S><F><M><A><K><R><F><A><D><F><T><V><Y><R><N><R><T><L><Q><K><W><H><D><K><T><K><L><A><S><G><K><L><G><K><G><F><G><A><F><E><R><S><I><L><T><Q><I><D><H><I><L><M><D><K><E><R><L><L><R><R><T><Q><T><K><R><S><V><Y><R><V><L><G><K><P><E><P><A><A><Q><P><V><P><E><S><L><P><G><E><P><E><I><L><P><Q><A><P><A><N><A><H><L><K><D><L><D><E><E><I><F><D><D><D><D><F><Y><H><Q><L><L><R><E><L><I><E><R><K><T><S><S><L><D><P><N><D><Q><V><A><M><G><R><Q><W><L><A><I><Q><K><L><R><S><K><I><H><K><K><V><D><R><K><A><S><K><G><R><K><L><R><F><H><V><L><S><K><L><L><S><F><M><A><P><I><D><H><T><T><M><N><D><D><A><R><T><E><L><Y><R><S><L><F><G><Q><L><H><P><P><D><E><G><H><G><D> | May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.<BOP> | Q9NY61 |
P50897 | PPT1_HUMAN | Palmitoyl-protein hydrolase 1 | Homo | <M><A><S><P><G><C><L><W><L><L><A><V><A><L><L><P><W><T><C><A><S><R><A><L><Q><H><L><D><P><P><A><P><L><P><L><V><I><W><H><G><M><G><D><S><C><C><N><P><L><S><M><G><A><I><K><K><M><V><E><K><K><I><P><G><I><Y><V><L><S><L><E><I><G><K><T><L><M><E><D><V><E><N><S><F><F><L><N><V><N><S><Q><V><T><T><V><C><Q><A><L><A><K><D><P><K><L><Q><Q><G><Y><N><A><M><G><F><S><Q><G><G><Q><F><L><R><A><V><A><Q><R><C><P><S><P><P><M><I><N><L><I><S><V><G><G><Q><H><Q><G><V><F><G><L><P><R><C><P><G><E><S><S><H><I><C><D><F><I><R><K><T><L><N><A><G><A><Y><S><K><V><V><Q><E><R><L><V><Q><A><E><Y><W><H><D><P><I><K><E><D><V><Y><R><N><H><S><I><F><L><A><D><I><N><Q><E><R><G><I><N><E><S><Y><K><K><N><L><M><A><L><K><K><F><V><M><V><K><F><L><N><D><S><I><V><D><P><V><D><S><E><W><F><G><F><Y><R><S><G><Q><A><K><E><T><I><P><L><Q><E><T><S><L><Y><T><Q><D><R><L><G><L><K><E><M><D><N><A><G><Q><L><V><F><L><A><T><E><G><D><H><L><Q><L><S><E><E><W><F><Y><A><H><I><I><P><F><L><G> | Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons .<BOP> | P50897 |
Q14973 | NTCP_HUMAN | Solute carrier family 10 member 1 | Homo | <M><E><A><H><N><A><S><A><P><F><N><F><T><L><P><P><N><F><G><K><R><P><T><D><L><A><L><S><V><I><L><V><F><M><L><F><F><I><M><L><S><L><G><C><T><M><E><F><S><K><I><K><A><H><L><W><K><P><K><G><L><A><I><A><L><V><A><Q><Y><G><I><M><P><L><T><A><F><V><L><G><K><V><F><R><L><K><N><I><E><A><L><A><I><L><V><C><G><C><S><P><G><G><N><L><S><N><V><F><S><L><A><M><K><G><D><M><N><L><S><I><V><M><T><T><C><S><T><F><C><A><L><G><M><M><P><L><L><L><Y><I><Y><S><R><G><I><Y><D><G><D><L><K><D><K><V><P><Y><K><G><I><V><I><S><L><V><L><V><L><I><P><C><T><I><G><I><V><L><K><S><K><R><P><Q><Y><M><R><Y><V><I><K><G><G><M><I><I><I><L><L><C><S><V><A><V><T><V><L><S><A><I><N><V><G><K><S><I><M><F><A><M><T><P><L><L><I><A><T><S><S><L><M><P><F><I><G><F><L><L><G><Y><V><L><S><A><L><F><C><L><N><G><R><C><R><R><T><V><S><M><E><T><G><C><Q><N><V><Q><L><C><S><T><I><L><N><V><A><F><P><P><E><V><I><G><P><L><F><F><F><P><L><L><Y><M><I><F><Q><L><G><E><G><L><L><L><I><A><I><F><W><C><Y><E><K><F><K><T><P><K><D><K><T><K><M><I><Y><T><A><A><T><T><E><E><T><I><P><G><A><L><G><N><G><T><Y><K><G><E><D><C><S><P><C><T><A> | (Microbial infection) Acts as a receptor for hepatitis B virus.<BOP> | Q14973 |
Q96LI5 | CNO6L_HUMAN | Carbon catabolite repressor protein 4 homolog B | Homo | <M><R><L><I><G><M><P><K><E><K><Y><D><P><P><D><P><R><R><I><Y><T><I><M><S><A><E><E><V><A><N><G><K><K><S><H><W><A><E><L><E><I><S><G><R><V><R><S><L><S><T><S><L><W><S><L><T><H><L><T><A><L><H><L><N><D><N><Y><L><S><R><I><P><P><D><I><A><K><L><H><N><L><V><Y><L><D><L><S><S><N><K><L><R><S><L><P><A><E><L><G><N><M><V><S><L><R><E><L><L><L><N><N><N><L><L><R><V><L><P><Y><E><L><G><R><L><F><Q><L><Q><T><L><G><L><K><G><N><P><L><S><Q><D><I><L><N><L><Y><Q><D><P><D><G><T><R><K><L><L><N><F><M><L><D><N><L><A><V><H><P><E><Q><L><P><P><R><P><W><I><T><L><K><E><R><D><Q><I><L><P><S><A><S><F><T><V><M><C><Y><N><V><L><C><D><K><Y><A><T><R><Q><L><Y><G><Y><C><P><S><W><A><L><N><W><E><Y><R><K><K><G><I><M><E><E><I><V><N><C><D><A><D><I><I><S><L><Q><E><V><E><T><E><Q><Y><F><T><L><F><L><P><A><L><K><E><R><G><Y><D><G><F><F><S><P><K><S><R><A><K><I><M><S><E><Q><E><R><K><H><V><D><G><C><A><I><F><F><K><T><E><K><F><T><L><V><Q><K><H><T><V><E><F><N><Q><V><A><M><A><N><S><D><G><S><E><A><M><L><N><R><V><M><T><K><D><N><I><G><V><A><V><V><L><E><V><H><K><E><L><F><G><A><G><M><K><P><I><H><A><A><D><K><Q><L><L><I><V><A><N><A><H><M><H><W><D><P><E><Y><S><D><V><K><L><I><Q><T><M><M><F><V><S><E><V><K><N><I><L><E><K><A><S><S><R><P><G><S><P><T><A><D><P><N><S><I><P><L><V><L><C><A><D><L><N><S><L><P><D><S><G><V><V><E><Y><L><S><N><G><G><V><A><D><N><H><K><D><F><K><E><L><R><Y><N><E><C><L><M><N><F><S><C><N><G><K><N><G><S><S><E><G><R><I><T><H><G><F><Q><L><K><S><A><Y><E><N><N><L><M><P><Y><T><N><Y><T><F><D><F><K><G><V><I><D><Y><I><F><Y><S><K><T><H><M><N><V><L><G><V><L><G><P><L><D><P><Q><W><L><V><E><N><N><I><T><G><C><P><H><P><H><I><P><S><D><H><F><S><L><L><T><Q><L><E><L><H><P><P><L><L><P><L><V><N><G><V><H><L><P><N><R><R> | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.<BOP> | Q96LI5 |
Q06323 | PSME1_HUMAN | Proteasome activator 28 subunit alpha | Homo | <M><A><M><L><R><V><Q><P><E><A><Q><A><K><V><D><V><F><R><E><D><L><C><T><K><T><E><N><L><L><G><S><Y><F><P><K><K><I><S><E><L><D><A><F><L><K><E><P><A><L><N><E><A><N><L><S><N><L><K><A><P><L><D><I><P><V><P><D><P><V><K><E><K><E><K><E><E><R><K><K><Q><Q><E><K><E><D><K><D><E><K><K><K><G><E><D><E><D><K><G><P><P><C><G><P><V><N><C><N><E><K><I><V><V><L><L><Q><R><L><K><P><E><I><K><D><V><I><E><Q><L><N><L><V><T><T><W><L><Q><L><Q><I><P><R><I><E><D><G><N><N><F><G><V><A><V><Q><E><K><V><F><E><L><M><T><S><L><H><T><K><L><E><G><F><H><T><Q><I><S><K><Y><F><S><E><R><G><D><A><V><T><K><A><A><K><Q><P><H><V><G><D><Y><R><Q><L><V><H><E><L><D><E><A><E><Y><R><D><I><R><L><M><V><M><E><I><R><N><A><Y><A><V><L><Y><D><I><I><L><K><N><F><E><K><L><K><K><P><R><G><E><T><K><G><M><I><Y> | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.<BOP> | Q06323 |
O15234 | CASC3_HUMAN | Protein barentsz | Homo | <M><A><D><R><R><R><Q><R><A><S><Q><D><T><E><D><E><E><S><G><A><S><G><S><D><S><G><G><S><P><L><R><G><G><G><S><C><S><G><S><A><G><G><G><G><S><G><S><L><P><S><Q><R><G><G><R><T><G><A><L><H><L><R><R><V><E><S><G><G><A><K><S><A><E><E><S><E><C><E><S><E><D><G><I><E><G><D><A><V><L><S><D><Y><E><S><A><E><D><S><E><G><E><E><G><E><Y><S><E><E><E><N><S><K><V><E><L><K><S><E><A><N><D><A><V><N><S><S><T><K><E><E><K><G><E><E><K><P><D><T><K><S><T><V><T><G><E><R><Q><S><G><D><G><Q><E><S><T><E><P><V><E><N><K><V><G><K><K><G><P><K><H><L><D><D><D><E><D><R><K><N><P><A><Y><I><P><R><K><G><L><F><F><E><H><D><L><R><G><Q><T><Q><E><E><E><V><R><P><K><G><R><Q><R><K><L><W><K><D><E><G><R><W><E><H><D><K><F><R><E><D><E><Q><A><P><K><S><R><Q><E><L><I><A><L><Y><G><Y><D><I><R><S><A><H><N><P><D><D><I><K><P><R><R><I><R><K><P><R><Y><G><S><P><P><Q><R><D><P><N><W><N><G><E><R><L><N><K><S><H><R><H><Q><G><L><G><G><T><L><P><P><R><T><F><I><N><R><N><A><A><G><T><G><R><M><S><A><P><R><N><Y><S><R><S><G><G><F><K><E><G><R><A><G><F><R><P><V><E><A><G><G><Q><H><G><G><R><S><G><E><T><V><K><H><E><I><S><Y><R><S><R><R><L><E><Q><T><S><V><R><D><P><S><P><E><A><D><A><P><V><L><G><S><P><E><K><E><E><A><A><S><E><P><P><A><A><A><P><D><A><A><P><P><P><P><D><R><P><I><E><K><K><S><Y><S><R><A><R><R><T><R><T><K><V><G><D><A><V><K><L><A><E><E><V><P><P><P><P><E><G><L><I><P><A><P><P><V><P><E><T><T><P><T><P><P><T><K><T><G><T><W><E><A><P><V><D><S><S><T><S><G><L><E><Q><D><V><A><Q><L><N><I><A><E><Q><N><W><S><P><G><Q><P><S><F><L><Q><P><R><E><L><R><G><M><P><N><H><I><H><M><G><A><G><P><P><P><Q><F><N><R><M><E><E><M><G><V><Q><G><G><R><A><K><R><Y><S><S><Q><R><Q><R><P><V><P><E><P><P><A><P><P><V><H><I><S><I><M><E><G><H><Y><Y><D><P><L><Q><F><Q><G><P><I><Y><T><H><G><D><S><P><A><P><L><P><P><Q><G><M><L><V><Q><P><G><M><N><L><P><H><P><G><L><H><P><H><Q><T><P><A><P><L><P><N><P><G><L><Y><P><P><P><V><S><M><S><P><G><Q><P><P><P><Q><Q><L><L><A><P><T><Y><F><S><A><P><G><V><M><N><F><G><N><P><S><Y><P><Y><A><P><G><A><L><P><P><P><P><P><P><H><L><Y><P><N><T><Q><A><P><S><Q><V><Y><G><G><V><T><Y><Y><N><P><A><Q><Q><Q><V><Q><P><K><P><S><P><P><R><R><T><P><Q><P><V><T><I><K><P><P><P><P><E><V><V><S><R><G><S><S> | Required for pre-mRNA splicing as component of the spliceosome . Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA | O15234 |
Q9NY33 | DPP3_HUMAN | Enkephalinase B | Homo | <M><A><D><T><Q><Y><I><L><P><N><D><I><G><V><S><S><L><D><C><R><E><A><F><R><L><L><S><P><T><E><R><L><Y><A><Y><H><L><S><R><A><A><W><Y><G><G><L><A><V><L><L><Q><T><S><P><E><A><P><Y><I><Y><A><L><L><S><R><L><F><R><A><Q><D><P><D><Q><L><R><Q><H><A><L><A><E><G><L><T><E><E><E><Y><Q><A><F><L><V><Y><A><A><G><V><Y><S><N><M><G><N><Y><K><S><F><G><D><T><K><F><V><P><N><L><P><K><E><K><L><E><R><V><I><L><G><S><E><A><A><Q><Q><H><P><E><E><V><R><G><L><W><Q><T><C><G><E><L><M><F><S><L><E><P><R><L><R><H><L><G><L><G><K><E><G><I><T><T><Y><F><S><G><N><C><T><M><E><D><A><K><L><A><Q><D><F><L><D><S><Q><N><L><S><A><Y><N><T><R><L><F><K><E><V><D><G><E><G><K><P><Y><Y><E><V><R><L><A><S><V><L><G><S><E><P><S><L><D><S><E><V><T><S><K><L><K><S><Y><E><F><R><G><S><P><F><Q><V><T><R><G><D><Y><A><P><I><L><Q><K><V><V><E><Q><L><E><K><A><K><A><Y><A><A><N><S><H><Q><G><Q><M><L><A><Q><Y><I><E><S><F><T><Q><G><S><I><E><A><H><K><R><G><S><R><F><W><I><Q><D><K><G><P><I><V><E><S><Y><I><G><F><I><E><S><Y><R><D><P><F><G><S><R><G><E><F><E><G><F><V><A><V><V><N><K><A><M><S><A><K><F><E><R><L><V><A><S><A><E><Q><L><L><K><E><L><P><W><P><P><T><F><E><K><D><K><F><L><T><P><D><F><T><S><L><D><V><L><T><F><A><G><S><G><I><P><A><G><I><N><I><P><N><Y><D><D><L><R><Q><T><E><G><F><K><N><V><S><L><G><N><V><L><A><V><A><Y><A><T><Q><R><E><K><L><T><F><L><E><E><D><D><K><D><L><Y><I><L><W><K><G><P><S><F><D><V><Q><V><G><L><H><E><L><L><G><H><G><S><G><K><L><F><V><Q><D><E><K><G><A><F><N><F><D><Q><E><T><V><I><N><P><E><T><G><E><Q><I><Q><S><W><Y><R><S><G><E><T><W><D><S><K><F><S><T><I><A><S><S><Y><E><E><C><R><A><E><S><V><G><L><Y><L><C><L><H><P><Q><V><L><E><I><F><G><F><E><G><A><D><A><E><D><V><I><Y><V><N><W><L><N><M><V><R><A><G><L><L><A><L><E><F><Y><T><P><E><A><F><N><W><R><Q><A><H><M><Q><A><R><F><V><I><L><R><V><L><L><E><A><G><E><G><L><V><T><I><T><P><T><T><G><S><D><G><R><P><D><A><R><V><R><L><D><R><S><K><I><R><S><V><G><K><P><A><L><E><R><F><L><R><R><L><Q><V><L><K><S><T><G><D><V><A><G><G><R><A><L><Y><E><G><Y><A><T><V><T><D><A><P><P><E><C><F><L><T><L><R><D><T><V><L><L><R><K><E><S><R><K><L><I><V><Q><P><N><T><R><L><E><G><S><D><V><Q><L><L><E><Y><E><A><S><A><A><G><L><I><R><S><F><S><E><R><F><P><E><D><G><P><E><L><E><E><I><L><T><Q><L><A><T><A><D><A><R><F><W><K><G><P><S><E><A><P><S><G><Q><A> | Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin . Also cleaves Arg-Arg-beta-naphthylamide (in vitro) .<BOP> | Q9NY33 |
P15907 | SIAT1_HUMAN | Sialyltransferase 1 | Homo | <M><I><H><T><N><L><K><K><K><F><S><C><C><V><L><V><F><L><L><F><A><V><I><C><V><W><K><E><K><K><K><G><S><Y><Y><D><S><F><K><L><Q><T><K><E><F><Q><V><L><K><S><L><G><K><L><A><M><G><S><D><S><Q><S><V><S><S><S><S><T><Q><D><P><H><R><G><R><Q><T><L><G><S><L><R><G><L><A><K><A><K><P><E><A><S><F><Q><V><W><N><K><D><S><S><S><K><N><L><I><P><R><L><Q><K><I><W><K><N><Y><L><S><M><N><K><Y><K><V><S><Y><K><G><P><G><P><G><I><K><F><S><A><E><A><L><R><C><H><L><R><D><H><V><N><V><S><M><V><E><V><T><D><F><P><F><N><T><S><E><W><E><G><Y><L><P><K><E><S><I><R><T><K><A><G><P><W><G><R><C><A><V><V><S><S><A><G><S><L><K><S><S><Q><L><G><R><E><I><D><D><H><D><A><V><L><R><F><N><G><A><P><T><A><N><F><Q><Q><D><V><G><T><K><T><T><I><R><L><M><N><S><Q><L><V><T><T><E><K><R><F><L><K><D><S><L><Y><N><E><G><I><L><I><V><W><D><P><S><V><Y><H><S><D><I><P><K><W><Y><Q><N><P><D><Y><N><F><F><N><N><Y><K><T><Y><R><K><L><H><P><N><Q><P><F><Y><I><L><K><P><Q><M><P><W><E><L><W><D><I><L><Q><E><I><S><P><E><E><I><Q><P><N><P><P><S><S><G><M><L><G><I><I><I><M><M><T><L><C><D><Q><V><D><I><Y><E><F><L><P><S><K><R><K><T><D><V><C><Y><Y><Y><Q><K><F><F><D><S><A><C><T><M><G><A><Y><H><P><L><L><Y><E><K><N><L><V><K><H><L><N><Q><G><T><D><E><D><I><Y><L><L><G><K><A><T><L><P><G><F><R><T><I><H><C> | Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.<BOP> | P15907 |
P11678 | PERE_HUMAN | Eosinophil peroxidase heavy chain | Homo | <M><H><L><L><P><A><L><A><G><V><L><A><T><L><V><L><A><Q><P><C><E><G><T><D><P><A><S><P><G><A><V><E><T><S><V><L><R><D><C><I><A><E><A><K><L><L><V><D><A><A><Y><N><W><T><Q><K><S><I><K><Q><R><L><R><S><G><S><A><S><P><M><D><L><L><S><Y><F><K><Q><P><V><A><A><T><R><T><V><V><R><A><A><D><Y><M><H><V><A><L><G><L><L><E><E><K><L><Q><P><Q><R><S><G><P><F><N><V><T><D><V><L><T><E><P><Q><L><R><L><L><S><Q><A><S><G><C><A><L><R><D><Q><A><E><R><C><S><D><K><Y><R><T><I><T><G><R><C><N><N><K><R><R><P><L><L><G><A><S><N><Q><A><L><A><R><W><L><P><A><E><Y><E><D><G><L><S><L><P><F><G><W><T><P><S><R><R><R><N><G><F><L><L><P><L><V><R><A><V><S><N><Q><I><V><R><F><P><N><E><R><L><T><S><D><R><G><R><A><L><M><F><M><Q><W><G><Q><F><I><D><H><D><L><D><F><S><P><E><S><P><A><R><V><A><F><T><A><G><V><D><C><E><R><T><C><A><Q><L><P><P><C><F><P><I><K><I><P><P><N><D><P><R><I><K><N><Q><R><D><C><I><P><F><F><R><S><A><P><S><C><P><Q><N><K><N><R><V><R><N><Q><I><N><A><L><T><S><F><V><D><A><S><M><V><Y><G><S><E><V><S><L><S><L><R><L><R><N><R><T><N><Y><L><G><L><L><A><I><N><Q><R><F><Q><D><N><G><R><A><L><L><P><F><D><N><L><H><D><D><P><C><L><L><T><N><R><S><A><R><I><P><C><F><L><A><G><D><T><R><S><T><E><T><P><K><L><A><A><M><H><T><L><F><M><R><E><H><N><R><L><A><T><E><L><R><R><L><N><P><R><W><N><G><D><K><L><Y><N><E><A><R><K><I><M><G><A><M><V><Q><I><I><T><Y><R><D><F><L><P><L><V><L><G><K><A><R><A><R><R><T><L><G><H><Y><R><G><Y><C><S><N><V><D><P><R><V><A><N><V><F><T><L><A><F><R><F><G><H><T><M><L><Q><P><F><M><F><R><L><D><S><Q><Y><R><A><S><A><P><N><S><H><V><P><L><S><S><A><F><F><A><S><W><R><I><V><Y><E><G><G><I><D><P><I><L><R><G><L><M><A><T><P><A><K><L><N><R><Q><D><A><M><L><V><D><E><L><R><D><R><L><F><R><Q><V><R><R><I><G><L><D><L><A><A><L><N><M><Q><R><S><R><D><H><G><L><P><G><Y><N><A><W><R><R><F><C><G><L><S><Q><P><R><N><L><A><Q><L><S><R><V><L><K><N><Q><D><L><A><R><K><F><L><N><L><Y><G><T><P><D><N><I><D><I><W><I><G><A><I><A><E><P><L><L><P><G><A><R><V><G><P><L><L><A><C><L><F><E><N><Q><F><R><R><A><R><D><G><D><R><F><W><W><Q><K><R><G><V><F><T><K><R><Q><R><K><A><L><S><R><I><S><L><S><R><I><I><C><D><N><T><G><I><T><T><V><S><R><D><I><F><R><A><N><I><Y><P><R><G><F><V><N><C><S><R><I><P><R><L><N><L><S><A><W><R><G><T> | Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.<BOP> | P11678 |
P05813 | CRBA1_HUMAN | Beta-crystallin A3, isoform A1, Delta8 form | Homo | <M><E><T><Q><A><E><Q><Q><E><L><E><T><L><P><T><T><K><M><A><Q><T><N><P><T><P><G><S><L><G><P><W><K><I><T><I><Y><D><Q><E><N><F><Q><G><K><R><M><E><F><T><S><S><C><P><N><V><S><E><R><S><F><D><N><V><R><S><L><K><V><E><S><G><A><W><I><G><Y><E><H><T><S><F><C><G><Q><Q><F><I><L><E><R><G><E><Y><P><R><W><D><A><W><S><G><S><N><A><Y><H><I><E><R><L><M><S><F><R><P><I><C><S><A><N><H><K><E><S><K><M><T><I><F><E><K><E><N><F><I><G><R><Q><W><E><I><S><D><D><Y><P><S><L><Q><A><M><G><W><F><N><N><E><V><G><S><M><K><I><Q><S><G><A><W><V><C><Y><Q><Y><P><G><Y><R><G><Y><Q><Y><I><L><E><C><D><H><H><G><G><D><Y><K><H><W><R><E><W><G><S><H><A><Q><T><S><Q><I><Q><S><I><R><R><I><Q><Q> | Crystallins are the dominant structural components of the vertebrate eye lens.<BOP> | P05813 |
Q5VTY9 | HHAT_HUMAN | Skinny hedgehog protein 1 | Homo | <M><L><P><R><W><E><L><A><L><Y><L><L><A><S><L><G><F><H><F><Y><S><F><Y><E><V><Y><K><V><S><R><E><H><E><E><E><L><D><Q><E><F><E><L><E><T><D><T><L><F><G><G><L><K><K><D><A><T><D><F><E><W><S><F><W><M><E><W><G><K><Q><W><L><V><W><L><L><L><G><H><M><V><V><S><Q><M><A><T><L><L><A><R><K><H><R><P><W><I><L><M><L><Y><G><M><W><A><C><W><C><V><L><G><T><P><G><V><A><M><V><L><L><H><T><T><I><S><F><C><V><A><Q><F><R><S><Q><L><L><T><W><L><C><S><L><L><L><L><S><T><L><R><L><Q><G><V><E><E><V><K><R><R><W><Y><K><T><E><N><E><Y><Y><L><L><Q><F><T><L><T><V><R><C><L><Y><Y><T><S><F><S><L><E><L><C><W><Q><Q><L><P><A><A><S><T><S><Y><S><F><P><W><M><L><A><Y><V><F><Y><Y><P><V><L><H><N><G><P><I><L><S><F><S><E><F><I><K><Q><M><Q><Q><Q><E><H><D><S><L><K><A><S><L><C><V><L><A><L><G><L><G><R><L><L><C><W><W><W><L><A><E><L><M><A><H><L><M><Y><M><H><A><I><Y><S><S><I><P><L><L><E><T><V><S><C><W><T><L><G><G><L><A><L><A><Q><V><L><F><F><Y><V><K><Y><L><V><L><F><G><V><P><A><L><L><M><R><L><D><G><L><T><P><P><A><L><P><R><C><V><S><T><M><F><S><F><T><G><M><W><R><Y><F><D><V><G><L><H><N><F><L><I><R><Y><V><Y><I><P><V><G><G><S><Q><H><G><L><L><G><T><L><F><S><T><A><M><T><F><A><F><V><S><Y><W><H><G><G><Y><D><Y><L><W><C><W><A><A><L><N><W><L><G><V><T><V><E><N><G><V><R><R><L><V><E><T><P><C><I><Q><D><S><L><A><R><Y><F><S><P><Q><A><R><R><R><F><H><A><A><L><A><S><C><S><T><S><M><L><I><L><S><N><L><V><F><L><G><G><N><E><V><G><K><T><Y><W><N><R><I><F><I><Q><G><W><P><W><V><T><L><S><V><L><G><F><L><Y><C><Y><S><H><V><G><I><A><W><A><Q><T><Y><A><T><D> | Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling . It also catalyzes N-terminal palmitoylation of DHH . Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs . It is an essential factor for proper embryonic development and testicular organogenesis .<BOP> | Q5VTY9 |
Q15884 | EREP1_HUMAN | Endosomal transmembrane binding with epsin | Homo | <M><I><L><L><V><N><L><F><V><L><L><S><V><V><C><V><L><L><N><L><A><G><F><I><L><G><C><Q><G><A><Q><F><V><S><S><V><P><R><C><D><L><V><D><L><G><E><G><K><I><C><F><C><C><E><E><F><Q><P><A><K><C><T><D><K><E><N><A><L><K><L><F><P><V><Q><P><C><S><A><V><H><L><L><L><K><K><V><L><F><A><L><C><A><L><N><A><L><T><T><T><V><C><L><V><A><A><A><L><R><Y><L><Q><I><F><A><T><R><R><S><C><I><D><E><S><Q><I><S><A><E><E><A><E><D><H><G><R><I><P><D><P><D><D><F><V><P><P><V><P><P><P><S><Y><F><A><T><F><Y><S><C><T><P><R><M><N><R><R><M><V><G><P><D><V><I><P><L><P><H><I><Y><G><A><R><I><K><G><V><E><V><F><C><P><L><D><P><P><P><P><Y><E><A><V><V><S><Q><M><D><Q><E><Q><G><S><S><F><Q><M><S><E><G><S><E><A><A><V><I><P><L><D><L><G><C><T><Q><V><T><Q><D><G><D><I><P><N><I><P><A><E><E><N><A><S><T><S><T><P><S><S><T><L><V><R><P><I><R><S><R><R><A><L><P><P><L><R><T><R><S><K><S><D><P><V><L><H><P><S><E><E><R><A><A><P><V><L><S><C><E><A><A><T><Q><T><E><R><R><L><D><L><A><A><V><T><L><R><R><G><L><R><S><R><A><S><R><C><R><P><R><S><L><I><D><Y><K><S><Y><M><D><T><K><L><L><V><A><R><F><L><E><Q><S><S><C><T><M><T><P><D><I><H><E><L><V><E><N><I><K><S><V><L><K><S><D><E><E><H><M><E><E><A><I><T><S><A><S><F><L><E><Q><I><M><A><P><L><Q><P><S><T><S><R><A><H><K><L><P><S><R><R><Q><P><G><L><L><H><L><Q><S><C><G><D><L><H><T><F><T><P><A><G><R><P><R><A><E><R><R><P><R><R><V><E><A><E><R><P><H><S><L><I><G><V><I><R><E><T><V><L> | Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.<BOP> | Q15884 |
Q9HCS2 | CP4FC_HUMAN | CYPIVF12 | Homo | <M><S><L><L><S><L><P><W><L><G><L><R><P><V><A><T><S><P><W><L><L><L><L><L><V><V><G><S><W><L><L><A><R><I><L><A><W><T><Y><A><F><Y><N><N><C><R><R><L><Q><C><F><P><Q><P><P><K><R><N><W><F><W><G><H><L><G><L><I><T><P><T><E><E><G><L><K><N><S><T><Q><M><S><A><T><Y><S><Q><G><F><T><V><W><L><G><P><I><I><P><F><I><V><L><C><H><P><D><T><I><R><S><I><T><N><A><S><A><A><I><A><P><K><D><N><L><F><I><R><F><L><K><P><W><L><G><E><G><I><L><L><S><G><G><D><K><W><S><R><H><R><R><M><L><T><P><A><F><H><F><N><I><L><K><S><Y><I><T><I><F><N><K><S><A><N><I><M><L><D><K><W><Q><H><L><A><S><E><G><S><S><R><L><D><M><F><E><H><I><S><L><M><T><L><D><S><L><Q><K><C><I><F><S><F><D><S><H><C><Q><E><R><P><S><E><Y><I><A><T><I><L><E><L><S><A><L><V><E><K><R><S><Q><H><I><L><Q><H><M><D><F><L><Y><Y><L><S><H><D><G><R><R><F><H><R><A><C><R><L><V><H><D><F><T><D><A><V><I><R><E><R><R><R><T><L><P><T><Q><G><I><D><D><F><F><K><D><K><A><K><S><K><T><L><D><F><I><D><V><L><L><L><S><K><D><E><D><G><K><A><L><S><D><E><D><I><R><A><E><A><D><T><F><M><F><G><G><H><D><T><T><A><S><G><L><S><W><V><L><Y><N><L><A><R><H><P><E><Y><Q><E><R><C><R><Q><E><V><Q><E><L><L><K><D><R><D><P><K><E><I><E><W><D><D><L><A><Q><L><P><F><L><T><M><C><V><K><E><S><L><R><L><H><P><P><A><P><F><I><S><R><C><C><T><Q><D><I><V><L><P><D><G><R><V><I><P><K><G><I><T><C><L><I><D><I><I><G><V><H><H><N><P><T><V><W><P><D><P><E><V><Y><D><P><F><R><F><D><P><E><N><S><K><G><R><S><P><L><A><F><I><P><F><S><A><G><P><R><N><C><I><G><Q><A><F><A><M><A><E><M><K><V><V><L><A><L><M><L><L><H><F><R><F><L><P><D><H><T><E><P><R><R><K><L><E><L><I><M><R><A><E><G><G><L><W><L><R><V><E><P><L><N><V><S><L><Q> | A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-2 position. Metabolizes (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) toward 18-hydroxy arachidonate . Catalyzes the epoxidation of double bonds of PUFAs such as docosapentaenoic and docosahexaenoic acids . Has low omega-hydroxylase activity toward leukotriene B4 and arachidonate . Involved in the metabolism of xenobiotics. Catalyzes the hydroxylation of the antihistamine drug ebastine .<BOP> | Q9HCS2 |
O94826 | TOM70_HUMAN | Translocase of outer mitochondrial membrane protein 70 | Homo | <M><A><A><S><K><P><V><E><A><A><V><V><A><A><A><V><P><S><S><G><S><G><V><G><G><G><G><T><A><G><P><G><T><G><G><L><P><R><W><Q><L><A><L><A><V><G><A><P><L><L><L><G><A><G><A><I><Y><L><W><S><R><Q><Q><R><R><R><E><A><R><G><R><G><D><A><S><G><L><K><R><N><S><E><R><K><T><P><E><G><R><A><S><P><A><P><G><S><G><H><P><E><G><P><G><A><H><L><D><M><N><S><L><D><R><A><Q><A><A><K><N><K><G><N><K><Y><F><K><A><G><K><Y><E><Q><A><I><Q><C><Y><T><E><A><I><S><L><C><P><T><E><K><N><V><D><L><S><T><F><Y><Q><N><R><A><A><A><F><E><Q><L><Q><K><W><K><E><V><A><Q><D><C><T><K><A><V><E><L><N><P><K><Y><V><K><A><L><F><R><R><A><K><A><H><E><K><L><D><N><K><K><E><C><L><E><D><V><T><A><V><C><I><L><E><G><F><Q><N><Q><Q><S><M><L><L><A><D><K><V><L><K><L><L><G><K><E><K><A><K><E><K><Y><K><N><R><E><P><L><M><P><S><P><Q><F><I><K><S><Y><F><S><S><F><T><D><D><I><I><S><Q><P><M><L><K><G><E><K><S><D><E><D><K><D><K><E><G><E><A><L><E><V><K><E><N><S><G><Y><L><K><A><K><Q><Y><M><E><E><E><N><Y><D><K><I><I><S><E><C><S><K><E><I><D><A><E><G><K><Y><M><A><E><A><L><L><L><R><A><T><F><Y><L><L><I><G><N><A><N><A><A><K><P><D><L><D><K><V><I><S><L><K><E><A><N><V><K><L><R><A><N><A><L><I><K><R><G><S><M><Y><M><Q><Q><Q><Q><P><L><L><S><T><Q><D><F><N><M><A><A><D><I><D><P><Q><N><A><D><V><Y><H><H><R><G><Q><L><K><I><L><L><D><Q><V><E><E><A><V><A><D><F><D><E><C><I><R><L><R><P><E><S><A><L><A><Q><A><Q><K><C><F><A><L><Y><R><Q><A><Y><T><G><N><N><S><S><Q><I><Q><A><A><M><K><G><F><E><E><V><I><K><K><F><P><R><C><A><E><G><Y><A><L><Y><A><Q><A><L><T><D><Q><Q><Q><F><G><K><A><D><E><M><Y><D><K><C><I><D><L><E><P><D><N><A><T><T><Y><V><H><K><G><L><L><Q><L><Q><W><K><Q><D><L><D><R><G><L><E><L><I><S><K><A><I><E><I><D><N><K><C><D><F><A><Y><E><T><M><G><T><I><E><V><Q><R><G><N><M><E><K><A><I><D><M><F><N><K><A><I><N><L><A><K><S><E><M><E><M><A><H><L><Y><S><L><C><D><A><A><H><A><Q><T><E><V><A><K><K><Y><G><L><K><P><P><T><L> | Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) . Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner . Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection . Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis .<BOP> | O94826 |
Q9NYZ2 | MFRN1_HUMAN | Solute carrier family 25 member 37 | Homo | <M><E><L><R><S><G><S><V><G><S><Q><A><V><A><R><R><M><D><G><D><S><R><D><G><G><G><G><K><D><A><T><G><S><E><D><Y><E><N><L><P><T><S><A><S><V><S><T><H><M><T><A><G><A><M><A><G><I><L><E><H><S><V><M><Y><P><V><D><S><V><K><T><R><M><Q><S><L><S><P><D><P><K><A><Q><Y><T><S><I><Y><G><A><L><K><K><I><M><R><T><E><G><F><W><R><P><L><R><G><V><N><V><M><I><M><G><A><G><P><A><H><A><M><Y><F><A><C><Y><E><N><M><K><R><T><L><N><D><V><F><H><H><Q><G><N><S><H><L><A><N><G><I><A><G><S><M><A><T><L><L><H><D><A><V><M><N><P><A><E><V><V><K><Q><R><L><Q><M><Y><N><S><Q><H><R><S><A><I><S><C><I><R><T><V><W><R><T><E><G><L><G><A><F><Y><R><S><Y><T><T><Q><L><T><M><N><I><P><F><Q><S><I><H><F><I><T><Y><E><F><L><Q><E><Q><V><N><P><H><R><T><Y><N><P><Q><S><H><I><I><S><G><G><L><A><G><A><L><A><A><A><A><T><T><P><L><D><V><C><K><T><L><L><N><T><Q><E><N><V><A><L><S><L><A><N><I><S><G><R><L><S><G><M><A><N><A><F><R><T><V><Y><Q><L><N><G><L><A><G><Y><F><K><G><I><Q><A><R><V><I><Y><Q><M><P><S><T><A><I><S><W><S><V><Y><E><F><F><K><Y><F><L><T><K><R><Q><L><E><N><R><A><P><Y> | Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.<BOP> | Q9NYZ2 |
P40199 | CEAM6_HUMAN | Normal cross-reacting antigen | Homo | <M><G><P><P><S><A><P><P><C><R><L><H><V><P><W><K><E><V><L><L><T><A><S><L><L><T><F><W><N><P><P><T><T><A><K><L><T><I><E><S><T><P><F><N><V><A><E><G><K><E><V><L><L><L><A><H><N><L><P><Q><N><R><I><G><Y><S><W><Y><K><G><E><R><V><D><G><N><S><L><I><V><G><Y><V><I><G><T><Q><Q><A><T><P><G><P><A><Y><S><G><R><E><T><I><Y><P><N><A><S><L><L><I><Q><N><V><T><Q><N><D><T><G><F><Y><T><L><Q><V><I><K><S><D><L><V><N><E><E><A><T><G><Q><F><H><V><Y><P><E><L><P><K><P><S><I><S><S><N><N><S><N><P><V><E><D><K><D><A><V><A><F><T><C><E><P><E><V><Q><N><T><T><Y><L><W><W><V><N><G><Q><S><L><P><V><S><P><R><L><Q><L><S><N><G><N><M><T><L><T><L><L><S><V><K><R><N><D><A><G><S><Y><E><C><E><I><Q><N><P><A><S><A><N><R><S><D><P><V><T><L><N><V><L><Y><G><P><D><V><P><T><I><S><P><S><K><A><N><Y><R><P><G><E><N><L><N><L><S><C><H><A><A><S><N><P><P><A><Q><Y><S><W><F><I><N><G><T><F><Q><Q><S><T><Q><E><L><F><I><P><N><I><T><V><N><N><S><G><S><Y><M><C><Q><A><H><N><S><A><T><G><L><N><R><T><T><V><T><M><I><T><V><S><G><S><A><P><V><L><S><A><V><A><T><V><G><I><T><I><G><V><L><A><R><V><A><L><I> | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression . Intercellular adhesion occurs in a calcium- and fibronectin-independent manner . Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 . Heterophilic interaction with CEACAM8 occurs in activated neutrophils . Plays a role in neutrophil adhesion to cytokine-activated endothelial cells . Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion . Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells .<BOP> | P40199 |
Q92696 | PGTA_HUMAN | Rab geranylgeranyltransferase subunit alpha | Homo | <M><H><G><R><L><K><V><K><T><S><E><E><Q><A><E><A><K><R><L><E><R><E><Q><K><L><K><L><Y><Q><S><A><T><Q><A><V><F><Q><K><R><Q><A><G><E><L><D><E><S><V><L><E><L><T><S><Q><I><L><G><A><N><P><D><F><A><T><L><W><N><C><R><R><E><V><L><Q><Q><L><E><T><Q><K><S><P><E><E><L><A><A><L><V><K><A><E><L><G><F><L><E><S><C><L><R><V><N><P><K><S><Y><G><T><W><H><H><R><C><W><L><L><G><R><L><P><E><P><N><W><T><R><E><L><E><L><C><A><R><F><L><E><V><D><E><R><N><F><H><C><W><D><Y><R><R><F><V><A><T><Q><A><A><V><P><P><A><E><E><L><A><F><T><D><S><L><I><T><R><N><F><S><N><Y><S><S><W><H><Y><R><S><C><L><L><P><Q><L><H><P><Q><P><D><S><G><P><Q><G><R><L><P><E><D><V><L><L><K><E><L><E><L><V><Q><N><A><F><F><T><D><P><N><D><Q><S><A><W><F><Y><H><R><W><L><L><G><R><A><D><P><Q><D><A><L><R><C><L><H><V><S><R><D><E><A><C><L><T><V><S><F><S><R><P><L><L><V><G><S><R><M><E><I><L><L><L><M><V><D><D><S><P><L><I><V><E><W><R><T><P><D><G><R><N><R><P><S><H><V><W><L><C><D><L><P><A><A><S><L><N><D><Q><L><P><Q><H><T><F><R><V><I><W><T><A><G><D><V><Q><K><E><C><V><L><L><K><G><R><Q><E><G><W><C><R><D><S><T><T><D><E><Q><L><F><R><C><E><L><S><V><E><K><S><T><V><L><Q><S><E><L><E><S><C><K><E><L><Q><E><L><E><P><E><N><K><W><C><L><L><T><I><I><L><L><M><R><A><L><D><P><L><L><Y><E><K><E><T><L><Q><Y><F><Q><T><L><K><A><V><D><P><M><R><A><T><Y><L><D><D><L><R><S><K><F><L><L><E><N><S><V><L><K><M><E><Y><A><E><V><R><V><L><H><L><A><H><K><D><L><T><V><L><C><H><L><E><Q><L><L><L><V><T><H><L><D><L><S><H><N><R><L><R><T><L><P><P><A><L><A><A><L><R><C><L><E><V><L><Q><A><S><D><N><A><I><E><S><L><D><G><V><T><N><L><P><R><L><Q><E><L><L><L><C><N><N><R><L><Q><Q><P><A><V><L><Q><P><L><A><S><C><P><R><L><V><L><L><N><L><Q><G><N><P><L><C><Q><A><V><G><I><L><E><Q><L><A><E><L><L><P><S><V><S><S><V><L><T> | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.<BOP> | Q92696 |
Q8NCW5 | NNRE_HUMAN | YjeF N-terminal domain-containing protein 1 | Homo | <M><S><R><L><R><A><L><L><G><L><G><L><L><V><A><G><S><R><V><P><R><I><K><S><Q><T><I><A><C><R><S><G><P><T><W><W><G><P><Q><R><L><N><S><G><G><R><W><D><S><E><V><M><A><S><T><V><V><K><Y><L><S><Q><E><E><A><Q><A><V><D><Q><E><L><F><N><E><Y><Q><F><S><V><D><Q><L><M><E><L><A><G><L><S><C><A><T><A><I><A><K><A><Y><P><P><T><S><M><S><R><S><P><P><T><V><L><V><I><C><G><P><G><N><N><G><G><D><G><L><V><C><A><R><H><L><K><L><F><G><Y><E><P><T><I><Y><Y><P><K><R><P><N><K><P><L><F><T><A><L><V><T><Q><C><Q><K><M><D><I><P><F><L><G><E><M><P><A><E><P><M><T><I><D><E><L><Y><E><L><V><V><D><A><I><F><G><F><S><F><K><G><D><V><R><E><P><F><H><S><I><L><S><V><L><K><G><L><T><V><P><I><A><S><I><D><I><P><S><G><W><D><V><E><K><G><N><A><G><G><I><Q><P><D><L><L><I><S><L><T><A><P><K><K><S><A><T><Q><F><T><G><R><Y><H><Y><L><G><G><R><F><V><P><P><A><L><E><K><K><Y><Q><L><N><L><P><P><Y><P><D><T><E><C><V><Y><R><L><Q> | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis .<BOP> | Q8NCW5 |
Q8IVV7 | GID4_HUMAN | Vacuolar import and degradation protein 24 homolog | Homo | <M><C><A><R><G><Q><V><G><R><G><T><Q><L><R><T><G><R><P><C><S><Q><V><P><G><S><R><W><R><P><E><R><L><L><R><R><Q><R><A><G><G><R><P><S><R><P><H><P><A><R><A><R><P><G><L><S><L><P><A><T><L><L><G><S><R><A><A><A><A><V><P><L><P><L><P><P><A><L><A><P><G><D><P><A><M><P><V><R><T><E><C><P><P><P><A><G><A><S><A><A><S><A><A><S><L><I><P><P><P><P><I><N><T><Q><Q><P><G><V><A><T><S><L><L><Y><S><G><S><K><F><R><G><H><Q><K><S><K><G><N><S><Y><D><V><E><V><V><L><Q><H><V><D><T><G><N><S><Y><L><C><G><Y><L><K><I><K><G><L><T><E><E><Y><P><T><L><T><T><F><F><E><G><E><I><I><S><K><K><H><P><F><L><T><R><K><W><D><A><D><E><D><V><D><R><K><H><W><G><K><F><L><A><F><Y><Q><Y><A><K><S><F><N><S><D><D><F><D><Y><E><E><L><K><N><G><D><Y><V><F><M><R><W><K><E><Q><F><L><V><P><D><H><T><I><K><D><I><S><G><A><S><F><A><G><F><Y><Y><I><C><F><Q><K><S><A><A><S><I><E><G><Y><Y><Y><H><R><S><S><E><W><Y><Q><S><L><N><L><T><H><V><P><E><H><S><A><P><I><Y><E><F><R> | Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) . Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp . Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue .<BOP> | Q8IVV7 |
Q7Z6V5 | ADAT2_HUMAN | tRNA-specific adenosine-34 deaminase subunit ADAT2 | Homo | <M><E><A><K><A><A><P><K><P><A><A><S><G><A><C><S><V><S><A><E><E><T><E><K><W><M><E><E><A><M><H><M><A><K><E><A><L><E><N><T><E><V><P><V><G><C><L><M><V><Y><N><N><E><V><V><G><K><G><R><N><E><V><N><Q><T><K><N><A><T><R><H><A><E><M><V><A><I><D><Q><V><L><D><W><C><R><Q><S><G><K><S><P><S><E><V><F><E><H><T><V><L><Y><V><T><V><E><P><C><I><M><C><A><A><A><L><R><L><M><K><I><P><L><V><V><Y><G><C><Q><N><E><R><F><G><G><C><G><S><V><L><N><I><A><S><A><D><L><P><N><T><G><R><P><F><Q><C><I><P><G><Y><R><A><E><E><A><V><E><M><L><K><T><F><Y><K><Q><E><N><P><N><A><P><K><S><K><V><R><K><K><E><C><Q><K><S> | Probably participates in deamination of adenosine-34 to inosine in many tRNAs.<BOP> | Q7Z6V5 |
P30874 | SSR2_HUMAN | SRIF-1 | Homo | <M><D><M><A><D><E><P><L><N><G><S><H><T><W><L><S><I><P><F><D><L><N><G><S><V><V><S><T><N><T><S><N><Q><T><E><P><Y><Y><D><L><T><S><N><A><V><L><T><F><I><Y><F><V><V><C><I><I><G><L><C><G><N><T><L><V><I><Y><V><I><L><R><Y><A><K><M><K><T><I><T><N><I><Y><I><L><N><L><A><I><A><D><E><L><F><M><L><G><L><P><F><L><A><M><Q><V><A><L><V><H><W><P><F><G><K><A><I><C><R><V><V><M><T><V><D><G><I><N><Q><F><T><S><I><F><C><L><T><V><M><S><I><D><R><Y><L><A><V><V><H><P><I><K><S><A><K><W><R><R><P><R><T><A><K><M><I><T><M><A><V><W><G><V><S><L><L><V><I><L><P><I><M><I><Y><A><G><L><R><S><N><Q><W><G><R><S><S><C><T><I><N><W><P><G><E><S><G><A><W><Y><T><G><F><I><I><Y><T><F><I><L><G><F><L><V><P><L><T><I><I><C><L><C><Y><L><F><I><I><I><K><V><K><S><S><G><I><R><V><G><S><S><K><R><K><K><S><E><K><K><V><T><R><M><V><S><I><V><V><A><V><F><I><F><C><W><L><P><F><Y><I><F><N><V><S><S><V><S><M><A><I><S><P><T><P><A><L><K><G><M><F><D><F><V><V><V><L><T><Y><A><N><S><C><A><N><P><I><L><Y><A><F><L><S><D><N><F><K><K><S><F><Q><N><V><L><C><L><V><K><V><S><G><T><D><D><G><E><R><S><D><S><K><Q><D><K><S><R><L><N><E><T><T><E><T><Q><R><T><L><L><N><G><D><L><Q><T><S><I> | Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.<BOP> | P30874 |
Q9HBL8 | NMRL1_HUMAN | NmrA-like family domain-containing protein 1 | Homo | <M><V><D><K><K><L><V><V><V><F><G><G><T><G><A><Q><G><G><S><V><A><R><T><L><L><E><D><G><T><F><K><V><R><V><V><T><R><N><P><R><K><K><A><A><K><E><L><R><L><Q><G><A><E><V><V><Q><G><D><Q><D><D><Q><V><I><M><E><L><A><L><N><G><A><Y><A><T><F><I><V><T><N><Y><W><E><S><C><S><Q><E><Q><E><V><K><Q><G><K><L><L><A><D><L><A><R><R><L><G><L><H><Y><V><V><Y><S><G><L><E><N><I><K><K><L><T><A><G><R><L><A><A><A><H><F><D><G><K><G><E><V><E><E><Y><F><R><D><I><G><V><P><M><T><S><V><R><L><P><C><Y><F><E><N><L><L><S><H><F><L><P><Q><K><A><P><D><G><K><S><Y><L><L><S><L><P><T><G><D><V><P><M><D><G><M><S><V><S><D><L><G><P><V><V><L><S><L><L><K><M><P><E><K><Y><V><G><Q><N><I><G><L><S><T><C><R><H><T><A><E><E><Y><A><A><L><L><T><K><H><T><R><K><V><V><H><D><A><K><M><T><P><E><D><Y><E><K><L><G><F><P><G><A><R><D><L><A><N><M><F><R><F><Y><A><L><R><P><D><R><D><I><E><L><T><L><R><L><N><P><K><A><L><T><L><D><Q><W><L><E><Q><H><K><G><D><F><N><L><L> | Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.<BOP> | Q9HBL8 |
P54727 | RD23B_HUMAN | XP-C repair-complementing complex 58 kDa protein | Homo | <M><Q><V><T><L><K><T><L><Q><Q><Q><T><F><K><I><D><I><D><P><E><E><T><V><K><A><L><K><E><K><I><E><S><E><K><G><K><D><A><F><P><V><A><G><Q><K><L><I><Y><A><G><K><I><L><N><D><D><T><A><L><K><E><Y><K><I><D><E><K><N><F><V><V><V><M><V><T><K><P><K><A><V><S><T><P><A><P><A><T><T><Q><Q><S><A><P><A><S><T><T><A><V><T><S><S><T><T><T><T><V><A><Q><A><P><T><P><V><P><A><L><A><P><T><S><T><P><A><S><I><T><P><A><S><A><T><A><S><S><E><P><A><P><A><S><A><A><K><Q><E><K><P><A><E><K><P><A><E><T><P><V><A><T><S><P><T><A><T><D><S><T><S><G><D><S><S><R><S><N><L><F><E><D><A><T><S><A><L><V><T><G><Q><S><Y><E><N><M><V><T><E><I><M><S><M><G><Y><E><R><E><Q><V><I><A><A><L><R><A><S><F><N><N><P><D><R><A><V><E><Y><L><L><M><G><I><P><G><D><R><E><S><Q><A><V><V><D><P><P><Q><A><A><S><T><G><A><P><Q><S><S><A><V><A><A><A><A><A><T><T><T><A><T><T><T><T><T><S><S><G><G><H><P><L><E><F><L><R><N><Q><P><Q><F><Q><Q><M><R><Q><I><I><Q><Q><N><P><S><L><L><P><A><L><L><Q><Q><I><G><R><E><N><P><Q><L><L><Q><Q><I><S><Q><H><Q><E><H><F><I><Q><M><L><N><E><P><V><Q><E><A><G><G><Q><G><G><G><G><G><G><G><S><G><G><I><A><E><A><G><S><G><H><M><N><Y><I><Q><V><T><P><Q><E><K><E><A><I><E><R><L><K><A><L><G><F><P><E><G><L><V><I><Q><A><Y><F><A><C><E><K><N><E><N><L><A><A><N><F><L><L><Q><Q><N><F><D><E><D> | The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to | P54727 |
P49281 | NRAM2_HUMAN | Solute carrier family 11 member 2 | Homo | <M><V><L><G><P><E><Q><K><M><S><D><D><S><V><S><G><D><H><G><E><S><A><S><L><G><N><I><N><P><A><Y><S><N><P><S><L><S><Q><S><P><G><D><S><E><E><Y><F><A><T><Y><F><N><E><K><I><S><I><P><E><E><E><Y><S><C><F><S><F><R><K><L><W><A><F><T><G><P><G><F><L><M><S><I><A><Y><L><D><P><G><N><I><E><S><D><L><Q><S><G><A><V><A><G><F><K><L><L><W><I><L><L><L><A><T><L><V><G><L><L><L><Q><R><L><A><A><R><L><G><V><V><T><G><L><H><L><A><E><V><C><H><R><Q><Y><P><K><V><P><R><V><I><L><W><L><M><V><E><L><A><I><I><G><S><D><M><Q><E><V><I><G><S><A><I><A><I><N><L><L><S><V><G><R><I><P><L><W><G><G><V><L><I><T><I><A><D><T><F><V><F><L><F><L><D><K><Y><G><L><R><K><L><E><A><F><F><G><F><L><I><T><I><M><A><L><T><F><G><Y><E><Y><V><T><V><K><P><S><Q><S><Q><V><L><K><G><M><F><V><P><S><C><S><G><C><R><T><P><Q><I><E><Q><A><V><G><I><V><G><A><V><I><M><P><H><N><M><Y><L><H><S><A><L><V><K><S><R><Q><V><N><R><N><N><K><Q><E><V><R><E><A><N><K><Y><F><F><I><E><S><C><I><A><L><F><V><S><F><I><I><N><V><F><V><V><S><V><F><A><E><A><F><F><G><K><T><N><E><Q><V><V><E><V><C><T><N><T><S><S><P><H><A><G><L><F><P><K><D><N><S><T><L><A><V><D><I><Y><K><G><G><V><V><L><G><C><Y><F><G><P><A><A><L><Y><I><W><A><V><G><I><L><A><A><G><Q><S><S><T><M><T><G><T><Y><S><G><Q><F><V><M><E><G><F><L><N><L><K><W><S><R><F><A><R><V><V><L><T><R><S><I><A><I><I><P><T><L><L><V><A><V><F><Q><D><V><E><H><L><T><G><M><N><D><F><L><N><V><L><Q><S><L><Q><L><P><F><A><L><I><P><I><L><T><F><T><S><L><R><P><V><M><S><D><F><A><N><G><L><G><W><R><I><A><G><G><I><L><V><L><I><I><C><S><I><N><M><Y><F><V><V><V><Y><V><R><D><L><G><H><V><A><L><Y><V><V><A><A><V><V><S><V><A><Y><L><G><F><V><F><Y><L><G><W><Q><C><L><I><A><L><G><M><S><F><L><D><C><G><H><T><C><H><L><G><L><T><A><Q><P><E><L><Y><L><L><N><T><M><D><A><D><S><L><V><S><R> | Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.<BOP> | P49281 |
Q9H4T2 | ZSC16_HUMAN | Zinc finger protein 435 | Homo | <M><T><T><A><L><E><P><E><D><Q><K><G><L><L><I><I><K><A><E><D><H><Y><W><G><Q><D><S><S><S><Q><K><C><S><P><H><R><R><E><L><Y><R><Q><H><F><R><K><L><C><Y><Q><D><A><P><G><P><R><E><A><L><T><Q><L><W><E><L><C><R><Q><W><L><R><P><E><C><H><T><K><E><Q><I><L><D><L><L><V><L><E><Q><F><L><S><I><L><P><K><D><L><Q><A><W><V><R><A><H><H><P><E><T><G><E><E><A><V><T><V><L><E><D><L><E><R><E><L><D><E><P><G><K><Q><V><P><G><N><S><E><R><R><D><I><L><M><D><K><L><A><P><L><G><R><P><Y><E><S><L><T><V><Q><L><H><P><K><K><T><Q><L><E><Q><E><A><G><K><P><Q><R><N><G><D><K><T><R><T><K><N><E><E><L><F><Q><K><E><D><M><P><K><D><K><E><F><L><G><E><I><N><D><R><L><N><K><D><T><P><Q><H><P><K><S><K><D><I><I><E><N><E><G><R><S><E><W><Q><Q><R><E><R><R><R><Y><K><C><D><E><C><G><K><S><F><S><H><S><S><D><L><S><K><H><R><R><T><H><T><G><E><K><P><Y><K><C><D><E><C><G><K><A><F><I><Q><R><S><H><L><I><G><H><H><R><V><H><T><G><V><K><P><Y><K><C><K><E><C><G><K><D><F><S><G><R><T><G><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><D><E><C><G><R><P><F><R><V><S><S><A><L><I><R><H><Q><R><I><H><T><A><N><K><L><Y> | May be involved in transcriptional regulation.<BOP> | Q9H4T2 |
P18075 | BMP7_HUMAN | Osteogenic protein 1 | Homo | <M><H><V><R><S><L><R><A><A><A><P><H><S><F><V><A><L><W><A><P><L><F><L><L><R><S><A><L><A><D><F><S><L><D><N><E><V><H><S><S><F><I><H><R><R><L><R><S><Q><E><R><R><E><M><Q><R><E><I><L><S><I><L><G><L><P><H><R><P><R><P><H><L><Q><G><K><H><N><S><A><P><M><F><M><L><D><L><Y><N><A><M><A><V><E><E><G><G><G><P><G><G><Q><G><F><S><Y><P><Y><K><A><V><F><S><T><Q><G><P><P><L><A><S><L><Q><D><S><H><F><L><T><D><A><D><M><V><M><S><F><V><N><L><V><E><H><D><K><E><F><F><H><P><R><Y><H><H><R><E><F><R><F><D><L><S><K><I><P><E><G><E><A><V><T><A><A><E><F><R><I><Y><K><D><Y><I><R><E><R><F><D><N><E><T><F><R><I><S><V><Y><Q><V><L><Q><E><H><L><G><R><E><S><D><L><F><L><L><D><S><R><T><L><W><A><S><E><E><G><W><L><V><F><D><I><T><A><T><S><N><H><W><V><V><N><P><R><H><N><L><G><L><Q><L><S><V><E><T><L><D><G><Q><S><I><N><P><K><L><A><G><L><I><G><R><H><G><P><Q><N><K><Q><P><F><M><V><A><F><F><K><A><T><E><V><H><F><R><S><I><R><S><T><G><S><K><Q><R><S><Q><N><R><S><K><T><P><K><N><Q><E><A><L><R><M><A><N><V><A><E><N><S><S><S><D><Q><R><Q><A><C><K><K><H><E><L><Y><V><S><F><R><D><L><G><W><Q><D><W><I><I><A><P><E><G><Y><A><A><Y><Y><C><E><G><E><C><A><F><P><L><N><S><Y><M><N><A><T><N><H><A><I><V><Q><T><L><V><H><F><I><N><P><E><T><V><P><K><P><C><C><A><P><T><Q><L><N><A><I><S><V><L><Y><F><D><D><S><S><N><V><I><L><K><K><Y><R><N><M><V><V><R><A><C><G><C><H> | Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis . Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A . Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes . For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor . Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors .<BOP> | P18075 |
Q49SQ1 | GPR33_HUMAN | Probable G-protein coupled receptor 33 | Homo | <M><D><L><I><N><S><T><D><Y><L><I><N><A><S><T><L><V><R><N><S><T><Q><F><L><A><P><A><S><K><M><I><I><A><L><S><L><Y><I><S><S><I><I><G><T><I><T><N><G><L><Y><L><W><V><L><R><F><K><M><K><Q><T><V><N><T><L><L><F><F><H><L><I><L><S><Y><F><I><S><T><M><I><L><P><F><M><A><T><S><Q><L><Q><D><N><H><W><N><F><G><T><A><L><C><K><V><F><N><G><T><L><S><L><G><M><F><T><S><V><F><F><L><S><A><I><G><L><D><R><Y><L><L><T><L><H><P><V><W><S><Q><Q><H><R><T><P><R><W><A><S><S><I><V><L><G><V><W><I><S><A><A><A><L><S><I><P><Y><L><I><F><R><E><T><H><H><D><R><K><G><K><V><T><C><Q><N><N><Y><A><V><S><T><N><W><E><S><K><E><M><Q><A><S><R><Q><W><I><H><V><A><C><F><I><S><R><F><L><L><G><F><L><L><P><F><F><I><I><I><F><C><Y><E><R><V><A><S><K><V><K><E><R><S><L><F><K><S><S><K><P><F><K><V><M><M><T><A><I><I><S><F><F><V><C><W><M><P><Y><H><I><H><Q><G><L><L><L><T><T><N><Q><S><L><L><L><E><L><T><L><I><L><T><V><L><T><T><S><F><N><T><I><F><S><P><T><L><Y><L><F><V><G><E><N><F><K><K><V><F><K><K><S><I><L><A><L><F><E><S><T><F><S><E><D><S><S><V><E><R><T><Q><T> | Orphan receptor; could be a chemoattractant receptor.<BOP> | Q49SQ1 |
Q8IZ16 | SACDR_HUMAN | Sperm acrosome developmental regulator | Homo | <M><V><V><V><M><K><F><F><R><W><V><R><R><A><W><Q><R><I><I><S><W><V><F><F><W><R><Q><K><I><K><P><T><I><S><G><H><P><D><S><K><K><H><S><L><K><K><M><E><K><T><L><Q><V><V><E><T><L><R><L><V><E><L><P><K><E><A><K><P><K><L><G><E><S><P><E><L><A><D><P><C><V><L><A><K><T><T><E><E><T><E><V><E><L><G><Q><Q><G><Q><S><L><L><Q><L><P><R><T><A><V><K><S><V><S><T><L><M><V><S><A><L><Q><S><G><W><Q><M><C><S><W><K><S><S><V><S><S><A><S><V><S><S><Q><V><R><T><Q><S><P><L><K><T><P><E><A><E><L><L><W><E><V><Y><L><V><L><W><A><V><R><K><H><L><R><R><L><Y><R><R><Q><E><R><H><R><R><H><H><V><R><C><H><A><A><P><R><P><N><P><A><Q><S><L><K><L><D><A><Q><S><P><L> | May play a role in acrosome formation and nucleus shaping during spermiogenesis.<BOP> | Q8IZ16 |
Q9UI95 | MD2L2_HUMAN | REV7 homolog | Homo | <M><T><T><L><T><R><Q><D><L><N><F><G><Q><V><V><A><D><V><L><C><E><F><L><E><V><A><V><H><L><I><L><Y><V><R><E><V><Y><P><V><G><I><F><Q><K><R><K><K><Y><N><V><P><V><Q><M><S><C><H><P><E><L><N><Q><Y><I><Q><D><T><L><H><C><V><K><P><L><L><E><K><N><D><V><E><K><V><V><V><V><I><L><D><K><E><H><R><P><V><E><K><F><V><F><E><I><T><Q><P><P><L><L><S><I><S><S><D><S><L><L><S><H><V><E><Q><L><L><R><A><F><I><L><K><I><S><V><C><D><A><V><L><D><H><N><P><P><G><C><T><F><T><V><L><V><H><T><R><E><A><A><T><R><N><M><E><K><I><Q><V><I><K><D><F><P><W><I><L><A><D><E><Q><D><V><H><M><H><D><P><R><L><I><P><L><K><T><M><T><S><D><I><L><K><M><Q><L><Y><V><E><E><R><A><H><K><G><S> | Adapter protein able to interact with different proteins and involved in different biological processes . Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis . Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions . Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) . During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection . Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres . May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 . Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle . Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-m | Q9UI95 |
P41181 | AQP2_HUMAN | Water channel protein for renal collecting duct | Homo | <M><W><E><L><R><S><I><A><F><S><R><A><V><F><A><E><F><L><A><T><L><L><F><V><F><F><G><L><G><S><A><L><N><W><P><Q><A><L><P><S><V><L><Q><I><A><M><A><F><G><L><G><I><G><T><L><V><Q><A><L><G><H><I><S><G><A><H><I><N><P><A><V><T><V><A><C><L><V><G><C><H><V><S><V><L><R><A><A><F><Y><V><A><A><Q><L><L><G><A><V><A><G><A><A><L><L><H><E><I><T><P><A><D><I><R><G><D><L><A><V><N><A><L><S><N><S><T><T><A><G><Q><A><V><T><V><E><L><F><L><T><L><Q><L><V><L><C><I><F><A><S><T><D><E><R><R><G><E><N><P><G><T><P><A><L><S><I><G><F><S><V><A><L><G><H><L><L><G><I><H><Y><T><G><C><S><M><N><P><A><R><S><L><A><P><A><V><V><T><G><K><F><D><D><H><W><V><F><W><I><G><P><L><V><G><A><I><L><G><S><L><L><Y><N><Y><V><L><F><P><P><A><K><S><L><S><E><R><L><A><V><L><K><G><L><E><P><D><T><D><W><E><E><R><E><V><R><R><R><Q><S><V><E><L><H><S><P><Q><S><L><P><R><G><T><K><A> | Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient . Plays an essential role in renal water homeostasis .<BOP> | P41181 |
Q9H2W1 | M4A6A_HUMAN | Four-span transmembrane protein 3 | Homo | <M><T><S><Q><P><V><P><N><E><T><I><I><V><L><P><S><N><V><I><N><F><S><Q><A><E><K><P><E><P><T><N><Q><G><Q><D><S><L><K><K><H><L><H><A><E><I><K><V><I><G><T><I><Q><I><L><C><G><M><M><V><L><S><L><G><I><I><L><A><S><A><S><F><S><P><N><F><T><Q><V><T><S><T><L><L><N><S><A><Y><P><F><I><G><P><F><F><F><I><I><S><G><S><L><S><I><A><T><E><K><R><L><T><K><L><L><V><H><S><S><L><V><G><S><I><L><S><A><L><S><A><L><V><G><F><I><I><L><S><V><K><Q><A><T><L><N><P><A><S><L><Q><C><E><L><D><K><N><N><I><P><T><R><S><Y><V><S><Y><F><Y><H><D><S><L><Y><T><T><D><C><Y><T><A><K><A><S><L><A><G><T><L><S><L><M><L><I><C><T><L><L><E><F><C><L><A><V><L><T><A><V><L><R><W><K><Q><A><Y><S><D><F><P><G><S><V><L><F><L><P><H><S><Y><I><G><N><S><G><M><S><S><K><M><T><H><D><C><G><Y><E><E><L><L><T><S> | May be involved in signal transduction as a component of a multimeric receptor complex.<BOP> | Q9H2W1 |
Q8N5T2 | TBC19_HUMAN | TBC1 domain family member 19 | Homo | <M><L><Q><E><E><S><D><L><S><L><I><I><A><Q><I><V><Q><K><L><K><G><S><N><L><Y><S><Q><L><E><R><Q><A><W><A><S><L><Q><R><P><E><I><K><L><E><S><L><K><E><D><I><K><E><F><F><K><I><S><G><W><E><K><K><L><Q><N><A><V><Y><S><E><L><S><V><F><P><L><P><S><H><P><A><A><P><P><E><H><L><K><E><P><L><V><Y><M><R><K><A><Q><G><S><W><E><K><R><I><L><K><S><L><N><S><M><C><T><E><L><S><I><P><L><A><R><K><R><P><V><G><E><Q><K><E><L><L><N><K><W><N><E><M><G><T><D><E><P><D><L><S><L><F><R><P><V><Y><A><P><K><D><F><L><E><V><L><I><N><L><R><N><P><N><Y><E><N><G><D><S><L><S><F><R><T><H><L><G><L><I><Q><V><P><L><K><V><K><D><I><P><E><L><K><E><C><F><V><E><L><G><L><N><I><G><Q><L><G><I><D><D><S><T><Q><V><P><P><E><L><F><E><N><E><H><V><R><I><G><Q><K><V><L><A><E><Q><D><S><A><A><A><Q><Q><Y><I><R><Q><G><S><P><T><A><L><R><A><E><L><W><A><L><I><L><N><I><S><S><Q><P><E><D><V><L><Y><Y><E><Q><L><K><T><N><V><I><Q><H><D><L><L><V><D><S><L><I><Y><K><D><V><K><L><T><A><S><N><D><D><Y><Y><F><V><F><E><D><Y><L><Y><Q><V><L><L><C><F><S><R><D><T><S><V><L><S><H><F><A><F><N><S><A><S><P><P><K><S><Y><I><R><G><K><L><G><L><E><E><Y><A><V><F><Y><P><P><N><G><V><I><P><F><H><G><F><S><M><Y><V><A><P><L><C><F><L><Y><H><E><P><S><K><L><Y><Q><I><F><R><E><M><Y><V><R><F><F><F><R><L><H><S><I><S><S><H><P><S><G><I><V><S><L><C><L><L><F><E><T><L><L><Q><T><Y><L><P><Q><L><F><Y><H><L><R><E><I><G><A><Q><P><L><R><I><S><F><K><W><M><V><R><A><F><S><G><Y><L><A><T><D><Q><L><L><L><L><W><D><R><I><L><G><Y><N><S><L><E><I><L><A><V><L><A><A><A><V><F><A><F><R><A><V><N><L><M><E><V><T><S><L><A><A><A><E><A><V><L><A><D><L><S><T><L><K><V><M><P><L><L><Q><I><F><L><F><A><T><V><T> | May act as a GTPase-activating protein for Rab family protein(s).<BOP> | Q8N5T2 |
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