accession stringlengths 6 10 | name stringlengths 8 11 | Full Name stringlengths 2 102 ⌀ | taxon stringclasses 1
value | sequence stringlengths 48 2.3k | function stringlengths 15 1.34k | AlphaFoldDB stringlengths 6 10 |
|---|---|---|---|---|---|---|
Q8NBJ4 | GOLM1_HUMAN | Golgi phosphoprotein 2 | Homo | <M><M><G><L><G><N><G><R><R><S><M><K><S><P><P><L><V><L><A><A><L><V><A><C><I><I><V><L><G><F><N><Y><W><I><A><S><S><R><S><V><D><L><Q><T><R><I><M><E><L><E><G><R><V><R><R><A><A><A><E><R><G><A><V><E><L><K><K><N><E><F><Q><G><E><L><E><K><Q><R><E><Q><L><D><K><I><Q><S><S><H><N><F><Q><L><E><S><V><N><K><L><Y><Q><D><E><K><A><V><L><V... | Unknown. Cellular response protein to viral infection.<BOP> | Q8NBJ4 |
Q86VF5 | MOGT3_HUMAN | Monoacylglycerol O-acyltransferase 3 | Homo | <M><G><V><A><T><T><L><Q><P><P><T><T><S><K><T><L><Q><K><Q><H><L><E><A><V><G><A><Y><Q><Y><V><L><T><F><L><F><M><G><P><F><F><S><L><L><V><F><V><L><L><F><T><S><L><W><P><F><S><V><F><Y><L><V><W><L><Y><V><D><W><D><T><P><N><Q><G><G><R><R><S><E><W><I><R><N><R><A><I><W><R><Q><L><R><D><Y><Y><P><V><K><L><V><K><T><A><E><L><P><P><D><R... | Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the s... | Q86VF5 |
Q14061 | COX17_HUMAN | Cytochrome c oxidase copper chaperone | Homo | <M><P><G><L><V><D><S><N><P><A><P><P><E><S><Q><E><K><K><P><L><K><P><C><C><A><C><P><E><T><K><K><A><R><D><A><C><I><I><E><K><G><E><E><H><C><G><H><L><I><E><A><H><K><E><C><M><R><A><L><G><F><K><I> | Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).<BO... | Q14061 |
P02743 | SAMP_HUMAN | Serum amyloid P-component(1-203) | Homo | <M><N><K><P><L><L><W><I><S><V><L><T><S><L><L><E><A><F><A><H><T><D><L><S><G><K><V><F><V><F><P><R><E><S><V><T><D><H><V><N><L><I><T><P><L><E><K><P><L><Q><N><F><T><L><C><F><R><A><Y><S><D><L><S><R><A><Y><S><L><F><S><Y><N><T><Q><G><R><D><N><E><L><L><V><Y><K><E><R><V><G><E><Y><S><L><Y><I><G><R><H><K><V><T><S><K><V><I><E><K><F... | Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.<BOP> | P02743 |
Q8NGY0 | O10X1_HUMAN | Olfactory receptor OR1-14 | Homo | <M><V><L><N><V><Y><C><C><F><F><Q><I><S><D><I><Q><T><M><K><I><N><Q><T><I><L><K><E><F><I><L><V><G><F><S><V><Y><P><H><V><Q><T><F><L><F><V><V><F><F><C><L><Y><L><L><T><L><A><G><N><L><I><I><M><G><L><T><W><V><D><R><S><L><H><T><P><M><Y><L><F><L><S><A><L><S><F><S><E><T><C><Y><T><L><T><I><V><P><K><M><L><E><D><L><L><A><K><D><R><S... | Odorant receptor.<BOP> | Q8NGY0 |
P42766 | RL35_HUMAN | Large ribosomal subunit protein uL29 | Homo | <M><A><K><I><K><A><R><D><L><R><G><K><K><K><E><E><L><L><K><Q><L><D><D><L><K><V><E><L><S><Q><L><R><V><A><K><V><T><G><G><A><A><S><K><L><S><K><I><R><V><V><R><K><S><I><A><R><V><L><T><V><I><N><Q><T><Q><K><E><N><L><R><K><F><Y><K><G><K><K><Y><K><P><L><D><L><R><P><K><K><T><R><A><M><R><R><R><L><N><K><H><E><E><N><L><K><T><K><K><Q... | Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP> | P42766 |
Q8IZ81 | ELMD2_HUMAN | ELMO domain-containing protein 2 | Homo | <M><F><I><S><L><W><E><F><F><Y><G><H><F><F><R><F><W><M><K><W><L><L><R><Q><M><T><G><K><C><E><L><Q><R><I><F><D><T><Y><V><G><A><Q><R><T><H><R><I><E><N><S><L><T><Y><S><K><N><K><V><L><Q><K><A><T><H><V><V><Q><S><E><V><D><K><Y><V><D><D><I><M><K><E><K><N><I><N><P><E><K><D><A><S><F><K><I><C><M><K><M><C><L><L><Q><I><T><G><Y><K><Q... | Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.<BOP> | Q8IZ81 |
Q9BT49 | THAP7_HUMAN | THAP domain-containing protein 7 | Homo | <M><P><R><H><C><S><A><A><G><C><C><T><R><D><T><R><E><T><R><N><R><G><I><S><F><H><R><L><P><K><K><D><N><P><R><R><G><L><W><L><A><N><C><Q><R><L><D><P><S><G><Q><G><L><W><D><P><A><S><E><Y><I><Y><F><C><S><K><H><F><E><E><D><C><F><E><L><V><G><I><S><G><Y><H><R><L><K><E><G><A><V><P><T><I><F><E><S><F><S><K><L><R><R><T><T><K><T><K><G... | Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.<BOP> | Q9BT49 |
Q96P56 | CTSR2_HUMAN | Cation channel sperm-associated protein 2 | Homo | <M><A><A><Y><Q><Q><E><E><Q><M><Q><L><P><R><A><D><A><I><R><S><R><L><I><D><T><F><S><L><I><E><H><L><Q><G><L><S><Q><A><V><P><R><H><T><I><R><E><L><L><D><P><S><R><Q><K><K><L><V><L><G><D><Q><H><Q><L><V><R><F><S><I><K><P><Q><R><I><E><Q><I><S><H><A><Q><R><L><L><S><R><L><H><V><R><C><S><Q><R><P><P><L><S><L><W><A><G><W><V><L><E><C... | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.<BOP> | Q96P56 |
Q8TD46 | MO2R1_HUMAN | Cell surface glycoprotein OX2 receptor 1 | Homo | <M><L><C><P><W><R><T><A><N><L><G><L><L><L><I><L><T><I><F><L><V><A><A><S><S><S><L><C><M><D><E><K><Q><I><T><Q><N><Y><S><K><V><L><A><E><V><N><T><S><W><P><V><K><M><A><T><N><A><V><L><C><C><P><P><I><A><L><R><N><L><I><I><I><T><W><E><I><I><L><R><G><Q><P><S><C><T><K><A><Y><K><K><E><T><N><E><T><K><E><T><N><C><T><D><E><R><I><T><W... | Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinit... | Q8TD46 |
P31314 | TLX1_HUMAN | T-cell leukemia/lymphoma protein 3 | Homo | <M><E><H><L><G><P><H><H><L><H><P><G><H><A><E><P><I><S><F><G><I><D><Q><I><L><N><S><P><D><Q><G><G><C><M><G><P><A><S><R><L><Q><D><G><E><Y><G><L><G><C><L><V><G><G><A><Y><T><Y><G><G><G><G><S><A><A><A><T><G><A><G><G><A><G><A><Y><G><T><G><G><P><G><G><P><G><G><P><A><G><G><G><G><A><C><S><M><G><P><L><T><G><S><Y><N><V><N><M><A><L... | Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.<BOP> | P31314 |
Q9NTI7 | INKA2_HUMAN | Inka box actin regulator 2 | Homo | <M><T><M><E><S><R><E><M><D><C><Y><L><R><R><L><K><Q><E><L><M><S><M><K><E><V><G><D><G><L><Q><D><Q><M><N><C><M><M><G><A><L><Q><E><L><K><L><L><Q><V><Q><T><A><L><E><Q><L><E><I><S><G><G><G><P><V><P><G><S><P><E><G><P><R><T><Q><C><E><H><P><C><W><E><G><G><R><G><P><A><R><P><T><V><C><S><P><S><S><Q><P><S><L><G><S><S><T><K><F><P><S... | Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.<BOP> | Q9NTI7 |
Q8N127 | O5AS1_HUMAN | Olfactory receptor OR11-168 | Homo | <M><L><E><S><N><Y><T><M><P><T><E><F><L><F><V><G><F><T><D><Y><L><P><L><R><V><T><L><F><L><V><F><L><L><V><Y><T><L><T><M><V><G><N><I><L><L><I><I><L><V><N><I><N><S><S><L><Q><I><P><M><Y><Y><F><L><S><N><L><S><F><L><D><I><S><C><S><T><A><I><T><P><K><M><L><A><N><F><L><A><S><R><K><S><I><S><P><Y><G><C><A><L><Q><M><F><F><F><A><S><F... | Odorant receptor.<BOP> | Q8N127 |
Q9BQ66 | KR412_HUMAN | Ultrahigh sulfur keratin-associated protein 4.12 | Homo | <M><V><N><S><C><C><G><S><V><C><S><D><Q><G><C><G><L><E><N><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><Q... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | Q9BQ66 |
A0A087WSY6 | KVD15_HUMAN | Immunoglobulin kappa variable 3D-15 | Homo | <M><E><A><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><G><E><I><V><M><T><Q><S><P><A><T><L><S><V><S><P><G><E><R><A><T><L><S><C><R><A><S><Q><S><V><S><S><N><L><A><W><Y><Q><Q><K><P><G><Q><A><P><R><L><L><I><Y><G><A><S><I><R><A><T><G><I><P><A><R><F><S><G><S><G><S><G><T><E><F><T><L><T><I><S><I><L><Q><S><E><D><F><A><V><Y><Y... | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | A0A087WSY6 |
Q96NL3 | ZN599_HUMAN | Zinc finger protein 599 | Homo | <M><A><A><P><A><L><A><L><V><S><F><E><D><V><V><V><T><F><T><G><E><E><W><G><H><L><D><L><A><Q><R><T><L><Y><Q><E><V><M><L><E><T><C><R><L><L><V><S><L><G><H><P><V><P><K><P><E><L><I><Y><L><L><E><H><G><Q><E><L><W><T><V><K><R><G><L><S><Q><S><T><C><A><G><E><K><A><K><P><K><I><T><E><P><T><A><S><Q><L><A><F><S><E><E><S><S><F><Q><E><L... | May be involved in transcriptional regulation.<BOP> | Q96NL3 |
Q16763 | UBE2S_HUMAN | Ubiquitin-protein ligase S | Homo | <M><N><S><N><V><E><N><L><P><P><H><I><I><R><L><V><Y><K><E><V><T><T><L><T><A><D><P><P><D><G><I><K><V><F><P><N><E><E><D><L><T><D><L><Q><V><T><I><E><G><P><E><G><T><P><Y><A><G><G><L><F><R><M><K><L><L><L><G><K><D><F><P><A><S><P><P><K><G><Y><F><L><T><K><I><F><H><P><N><V><G><A><N><G><E><I><C><V><N><V><L><K><R><D><W><T><A><E><L... | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specif... | Q16763 |
Q9BXJ5 | C1QT2_HUMAN | Complement C1q tumor necrosis factor-related protein 2 | Homo | <M><I><P><W><V><L><L><A><C><A><L><P><C><A><A><D><P><L><L><G><A><F><A><R><R><D><F><R><K><G><S><P><Q><L><V><C><S><L><P><G><P><Q><G><P><P><G><P><P><G><A><P><G><P><S><G><M><M><G><R><M><G><F><P><G><K><D><G><Q><D><G><H><D><G><D><R><G><D><S><G><E><E><G><P><P><G><R><T><G><N><R><G><K><P><G><P><K><G><K><A><G><A><I><G><R><A><G><P... | Involved in the regulation of lipid metabolism in adipose tissue and liver.<BOP> | Q9BXJ5 |
Q6NT32 | EST5A_HUMAN | Carboxylesterase-like urinary excreted protein homolog | Homo | <M><S><G><N><W><V><H><P><G><Q><I><L><I><W><A><I><W><V><L><A><A><P><T><K><G><P><S><A><E><G><P><Q><R><N><T><R><L><G><W><I><Q><G><K><Q><V><T><V><L><G><S><P><V><P><V><N><V><F><L><G><V><P><F><A><A><P><P><L><G><S><L><R><F><T><N><P><Q><P><A><S><P><W><D><N><L><R><E><A><T><S><Y><P><N><L><C><L><Q><N><S><E><W><L><L><L><D><Q><H><M... | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.<BOP> | Q6NT32 |
Q9UJG1 | MSPD1_HUMAN | Motile sperm domain-containing protein 1 | Homo | <M><H><Q><Q><K><R><Q><P><E><L><V><E><G><N><L><P><V><F><V><F><P><T><E><L><I><F><Y><A><D><D><Q><S><T><H><K><Q><V><L><T><L><Y><N><P><Y><E><F><A><L><K><F><K><V><L><C><T><T><P><N><K><Y><V><V><V><D><A><A><G><A><V><K><P><Q><C><C><V><D><I><V><I><R><H><R><D><V><R><S><C><H><Y><G><V><I><D><K><F><R><L><Q><V><S><E><Q><S><Q><R><K><A... | Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.<BOP> | Q9UJG1 |
Q6L8H2 | KRA53_HUMAN | Ultrahigh sulfur keratin-associated protein 5.3 | Homo | <M><G><C><S><G><C><S><G><G><C><G><S><S><C><G><G><C><G><S><S><C><G><G><C><G><S><G><Y><G><G><C><G><S><G><C><C><V><P><V><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><V><C><G><S><C><G><G><C><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><S><C><C><V><P><V><C><C><S><S><S><C><G><S><C><G><G><S... | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hai... | Q6L8H2 |
Q6P1Q9 | MET2B_HUMAN | Methyltransferase-like protein 2B | Homo | <M><A><G><S><Y><P><E><G><A><P><A><I><L><A><D><K><R><Q><Q><F><G><S><R><F><L><S><D><P><A><R><V><F><H><H><N><A><W><D><N><V><E><W><S><E><E><Q><A><A><A><A><E><R><K><V><Q><E><N><S><I><Q><R><V><C><Q><E><K><Q><V><D><Y><E><I><N><A><H><K><Y><W><N><D><F><Y><K><I><H><E><N><G><F><F><K><D><R><H><W><L><F><T><E><F><P><E><L><A><P><S><Q... | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).<BOP> | Q6P1Q9 |
P23083 | HV102_HUMAN | Ig heavy chain V-I region V35 | Homo | <M><D><W><T><W><R><I><L><F><L><V><A><A><A><T><G><A><H><S><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><A><S><V><K><V><S><C><K><A><S><G><Y><T><F><T><G><Y><Y><M><H><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><W><I><N><P><N><S><G><G><T><N><Y><A><Q><K><F><Q><G><W><V><T><M><T><R><D><T><S><I><S><T><A><Y><M><E><L><S><R><L><R><S... | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P23083 |
Q8WWZ1 | IL1FA_HUMAN | Interleukin-38 | Homo | <M><C><S><L><P><M><A><R><Y><Y><I><I><K><Y><A><D><Q><K><A><L><Y><T><R><D><G><Q><L><L><V><G><D><P><V><A><D><N><C><C><A><E><K><I><C><I><L><P><N><R><G><L><A><R><T><K><V><P><I><F><L><G><I><Q><G><G><S><R><C><L><A><C><V><E><T><E><E><G><P><S><L><Q><L><E><D><V><N><I><E><E><L><Y><K><G><G><E><E><A><T><R><F><T><F><F><Q><S><S><S><G... | Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bact... | Q8WWZ1 |
Q9NQZ3 | DAZ1_HUMAN | Deleted in azoospermia protein 1 | Homo | <M><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K... | RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.<BOP> | Q9NQZ3 |
P28072 | PSB6_HUMAN | Proteasome subunit Y | Homo | <M><A><A><T><L><L><A><A><R><G><A><G><P><A><P><A><W><G><P><E><A><F><T><P><D><W><E><S><R><E><V><S><T><G><T><T><I><M><A><V><Q><F><D><G><G><V><V><L><G><A><D><S><R><T><T><T><G><S><Y><I><A><N><R><V><T><D><K><L><T><P><I><H><D><R><I><F><C><C><R><S><G><S><A><A><D><T><Q><A><V><A><D><A><V><T><Y><Q><L><G><F><H><S><I><E><L><N><E><P... | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participate... | P28072 |
Q96A58 | RERG_HUMAN | Ras-related and estrogen-regulated growth inhibitor | Homo | <M><A><K><S><A><E><V><K><L><A><I><F><G><R><A><G><V><G><K><S><A><L><V><V><R><F><L><T><K><R><F><I><W><E><Y><D><P><T><L><E><S><T><Y><R><H><Q><A><T><I><D><D><E><V><V><S><M><E><I><L><D><T><A><G><Q><E><D><T><I><Q><R><E><G><H><M><R><W><G><E><G><F><V><L><V><Y><D><I><T><D><R><G><S><F><E><E><V><L><P><L><K><N><I><L><D><E><I><K><K... | Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.<BOP> | Q96A58 |
Q86WT6 | TRI69_HUMAN | Tripartite motif-containing protein 69 | Homo | <M><E><V><S><T><N><P><S><S><N><I><D><P><G><D><Y><V><E><M><N><D><S><I><T><H><L><P><S><K><V><V><I><Q><D><I><T><M><E><L><H><C><P><L><C><N><D><W><F><R><D><P><L><M><L><S><C><G><H><N><F><C><E><A><C><I><Q><D><F><W><R><L><Q><A><K><E><T><F><C><P><E><C><K><M><L><C><Q><Y><N><N><C><T><F><N><P><V><L><D><K><L><V><E><K><I><K><K><L><P... | May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.<BOP> | Q86WT6 |
W5XKT8 | SACA6_HUMAN | BACHELOR-like protein | Homo | <M><A><L><L><A><L><A><S><A><V><P><S><A><L><L><A><L><A><V><F><R><V><P><A><W><A><C><L><L><C><F><T><T><Y><S><E><R><L><R><I><C><Q><M><F><V><G><M><R><S><P><K><L><E><E><C><E><E><A><F><T><A><A><F><Q><G><L><S><D><T><E><I><N><Y><D><E><R><S><H><L><H><D><T><F><T><Q><M><T><H><A><L><Q><E><L><A><A><A><Q><G><S><F><E><V><A><F><P><D><A... | Sperm protein required for fusion of sperm with the egg membrane during fertilization.<BOP> | W5XKT8 |
Q6ZMR5 | TM11A_HUMAN | Esophageal cancer-susceptibility gene 1 protein | Homo | <M><M><Y><R><T><V><G><F><G><T><R><S><R><N><L><K><P><W><M><I><A><V><L><I><V><L><S><L><T><V><V><A><V><T><I><G><L><L><V><H><F><L><V><F><D><Q><K><K><E><Y><Y><H><G><S><F><K><I><L><D><P><Q><I><N><N><N><F><G><Q><S><N><T><Y><Q><L><K><D><L><R><E><T><T><E><N><L><V><D><E><I><F><I><D><S><A><W><K><K><N><Y><I><K><N><Q><V><V><R><L><T... | Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.<BOP> | Q6ZMR5 |
Q96L58 | B3GT6_HUMAN | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 | Homo | <M><K><L><L><R><R><A><W><R><R><R><A><A><L><G><L><G><T><L><A><L><C><G><A><A><L><L><Y><L><A><R><C><A><A><E><P><G><D><P><R><A><M><S><G><R><S><P><P><P><P><A><P><A><R><A><A><A><F><L><A><V><L><V><A><S><A><P><R><A><A><E><R><R><S><V><I><R><S><T><W><L><A><R><R><G><A><P><G><D><V><W><A><R><F><A><V><G><T><A><G><L><G><A><E><E><R><R... | Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substr... | Q96L58 |
P02649 | APOE_HUMAN | Apolipoprotein E | Homo | <M><K><V><L><W><A><A><L><L><V><T><F><L><A><G><C><Q><A><K><V><E><Q><A><V><E><T><E><P><E><P><E><L><R><Q><Q><T><E><W><Q><S><G><Q><R><W><E><L><A><L><G><R><F><W><D><Y><L><R><W><V><Q><T><L><S><E><Q><V><Q><E><E><L><L><S><S><Q><V><T><Q><E><L><R><A><L><M><D><E><T><M><K><E><L><K><A><Y><K><S><E><L><E><E><Q><L><T><P><V><A><E><E><T... | (Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles . This interaction is probably promoted via the up-regul... | P02649 |
Q8NCU7 | C2C4A_HUMAN | Protein FAM148A | Homo | <M><W><C><L><E><R><L><R><L><G><P><E><C><L><R><R><S><G><D><W><L><L><P><G><R><A><R><G><A><K><S><R><T><T><A><A><C><A><N><V><L><T><P><D><R><I><P><E><F><C><I><P><P><R><L><M><P><R><L><A><L><A><A><L><R><N><S><W><V><E><E><A><G><M><D><E><G><A><G><R><T><D><W><D><P><R><S><Q><A><A><L><S><L><P><H><L><P><R><V><R><T><A><Y><G><F><C><A... | May be involved in inflammatory process. May regulate cell architecture and adhesion.<BOP> | Q8NCU7 |
Q9BXC0 | HCAR1_HUMAN | G-protein coupled receptor 81 | Homo | <M><Y><N><G><S><C><C><R><I><E><G><D><T><I><S><Q><V><M><P><P><L><L><I><V><A><F><V><L><G><A><L><G><N><G><V><A><L><C><G><F><C><F><H><M><K><T><W><K><P><S><T><V><Y><L><F><N><L><A><V><A><D><F><L><L><M><I><C><L><P><F><R><T><D><Y><Y><L><R><R><R><H><W><A><F><G><D><I><P><C><R><V><G><L><F><T><L><A><M><N><R><A><G><S><I><V><F><L><T... | Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.<BOP> | Q9BXC0 |
Q5T0T0 | MARH8_HUMAN | RING-type E3 ubiquitin transferase MARCHF8 | Homo | <M><S><M><P><L><H><Q><I><S><A><I><P><S><Q><D><A><I><S><A><R><V><Y><R><S><K><T><K><E><K><E><R><E><E><Q><N><E><K><T><L><G><H><F><M><S><H><S><S><N><I><S><K><A><G><S><P><P><S><A><S><A><P><A><P><V><S><S><F><S><R><T><S><I><T><P><S><S><Q><D><I><C><R><I><C><H><C><E><G><D><D><E><S><P><L><I><T><P><C><H><C><T><G><S><L><H><F><V><H... | E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.<BOP> | Q5T0T0 |
Q15813 | TBCE_HUMAN | Tubulin-folding cofactor E | Homo | <M><S><D><T><L><T><A><D><V><I><G><R><R><V><E><V><N><G><E><H><A><T><V><R><F><A><G><V><V><P><P><V><A><G><P><W><L><G><V><E><W><D><N><P><E><R><G><K><H><D><G><S><H><E><G><T><V><Y><F><K><C><R><H><P><T><G><G><S><F><I><R><P><N><K><V><N><F><G><T><D><F><L><T><A><I><K><N><R><Y><V><L><E><D><G><P><E><E><D><R><K><E><Q><I><V><T><I><G... | Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.<BOP> | Q15813 |
Q99808 | S29A1_HUMAN | Solute carrier family 29 member 1 | Homo | <M><T><T><S><H><Q><P><Q><D><R><Y><K><A><V><W><L><I><F><F><M><L><G><L><G><T><L><L><P><W><N><F><F><M><T><A><T><Q><Y><F><T><N><R><L><D><M><S><Q><N><V><S><L><V><T><A><E><L><S><K><D><A><Q><A><S><A><A><P><A><A><P><L><P><E><R><N><S><L><S><A><I><F><N><N><V><M><T><L><C><A><M><L><P><L><L><L><F><T><Y><L><N><S><F><L><H><Q><R><I><P... | Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chem... | Q99808 |
P78424 | PO6F2_HUMAN | Retina-derived POU domain factor 1 | Homo | <M><S><A><L><L><Q><D><P><M><I><A><G><Q><V><S><K><P><L><L><S><V><R><S><E><M><N><A><E><L><R><G><E><D><K><A><A><T><S><D><S><E><L><N><E><P><L><L><A><P><V><E><S><N><D><S><E><D><T><P><S><K><L><F><G><A><R><G><N><P><A><L><S><D><P><G><T><P><D><Q><H><Q><A><S><Q><T><H><P><P><F><P><V><G><P><Q><P><L><L><T><A><Q><Q><L><A><S><A><V><A... | Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.<BOP> | P78424 |
Q8N2I2 | ZN619_HUMAN | Zinc finger protein 619 | Homo | <M><G><Q><P><A><P><Y><A><E><G><P><I><Q><G><G><D><A><G><E><L><C><K><C><D><F><L><V><S><I><S><I><P><Q><T><R><S><D><I><P><A><G><A><R><R><S><S><M><G><P><R><S><L><D><T><C><W><G><R><G><P><E><R><H><V><H><R><L><E><C><N><G><V><I><F><T><H><R><N><L><C><L><P><G><G><K><T><K><T><E><N><E><E><K><T><A><Q><L><N><I><S><K><E><S><E><S><H><R... | May be involved in transcriptional regulation.<BOP> | Q8N2I2 |
Q53GQ0 | DHB12_HUMAN | Short chain dehydrogenase/reductase family 12C member 1 | Homo | <M><E><S><A><L><P><A><A><G><F><L><Y><W><V><G><A><G><T><V><A><Y><L><A><L><R><I><S><Y><S><L><F><T><A><L><R><V><W><G><V><G><N><E><A><G><V><G><P><G><L><G><E><W><A><V><V><T><G><S><T><D><G><I><G><K><S><Y><A><E><E><L><A><K><H><G><M><K><V><V><L><I><S><R><S><K><D><K><L><D><Q><V><S><S><E><I><K><E><K><F><K><V><E><T><R><T><I><A><V... | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoac... | Q53GQ0 |
P51810 | GP143_HUMAN | Ocular albinism type 1 protein | Homo | <M><A><S><P><R><L><G><T><F><C><C><P><T><R><D><A><A><T><Q><L><V><L><S><F><Q><P><R><A><F><H><A><L><C><L><G><S><G><G><L><R><L><A><L><G><L><L><Q><L><L><P><G><R><R><P><A><G><P><G><S><P><A><T><S><P><P><A><S><V><R><I><L><R><A><A><A><A><C><D><L><L><G><C><L><G><M><V><I><R><S><T><V><W><L><G><F><P><N><F><V><D><S><V><S><D><M><N><H... | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its... | P51810 |
P08908 | 5HT1A_HUMAN | Serotonin receptor 1A | Homo | <M><D><V><L><S><P><G><Q><G><N><N><T><T><S><P><P><A><P><F><E><T><G><G><N><T><T><G><I><S><D><V><T><V><S><Y><Q><V><I><T><S><L><L><L><G><T><L><I><F><C><A><V><L><G><N><A><C><V><V><A><A><I><A><L><E><R><S><L><Q><N><V><A><N><Y><L><I><G><S><L><A><V><T><D><L><M><V><S><V><L><V><L><P><M><A><A><L><Y><Q><V><L><N><K><W><T><L><G><Q><V... | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such a... | P08908 |
O96008 | TOM40_HUMAN | p38.5 | Homo | <M><G><N><V><L><A><A><S><S><P><P><A><G><P><P><P><P><P><A><P><A><L><V><G><L><P><P><P><P><P><S><P><P><G><F><T><L><P><P><L><G><G><S><L><G><A><G><T><S><T><S><R><S><S><E><R><T><P><G><A><A><T><A><S><A><S><G><A><A><E><D><G><A><C><G><C><L><P><N><P><G><T><F><E><E><C><H><R><K><C><K><E><L><F><P><I><Q><M><E><G><V><K><L><T><V><N><K... | Channel-forming protein essential for import of protein precursors into mitochondria . Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria... | O96008 |
Q96DT0 | LEG12_HUMAN | Galectin-related inhibitor of proliferation | Homo | <M><S><Q><P><S><G><G><R><A><P><G><T><R><I><Y><S><W><S><C><P><T><V><M><S><P><G><E><K><L><D><P><I><P><D><S><F><I><L><Q><P><P><V><F><H><P><V><V><P><Y><V><T><T><I><F><G><G><L><H><A><G><K><M><V><M><L><Q><G><V><V><P><L><D><A><H><R><F><Q><V><D><F><Q><C><G><C><S><L><C><P><R><P><D><I><A><F><H><F><N><P><R><F><H><T><T><K><P><H><V... | Binds lactose. May participate in the apoptosis of adipocytes.<BOP> | Q96DT0 |
Q9UBP9 | GULP1_HUMAN | Protein GULP | Homo | <M><N><R><A><F><S><R><K><K><D><K><T><W><M><H><T><P><E><A><L><S><K><H><F><I><P><Y><N><A><K><F><L><G><S><T><E><V><E><Q><P><K><G><T><E><V><V><R><D><A><V><R><K><L><K><F><A><R><H><I><K><K><S><E><G><Q><K><I><P><K><V><E><L><Q><I><S><I><Y><G><V><K><I><L><E><P><K><T><K><E><V><Q><H><N><C><Q><L><H><R><I><S><F><C><A><D><D><K><T><D... | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.<BOP> | Q9UBP9 |
Q6P9B6 | MEAK7_HUMAN | TLD domain-containing protein 1 | Homo | <M><G><N><S><R><S><R><V><G><R><S><F><C><S><Q><F><L><P><E><E><Q><A><E><I><D><Q><L><F><D><A><L><S><S><D><K><N><S><P><N><V><S><S><K><S><F><S><L><K><A><L><Q><N><H><V><G><E><A><L><P><P><E><M><V><T><R><L><Y><D><G><M><R><R><V><D><L><T><G><K><A><K><G><P><S><E><N><V><S><Q><E><Q><F><T><A><S><M><S><H><L><L><K><G><N><S><E><E><K><S... | Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration . Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome .<BOP> | Q6P9B6 |
Q9BVK6 | TMED9_HUMAN | p25 | Homo | <M><A><V><E><L><G><V><L><L><V><R><P><R><P><G><T><G><L><G><R><V><M><R><T><L><L><L><V><L><W><L><A><T><R><G><S><A><L><Y><F><H><I><G><E><T><E><K><K><C><F><I><E><E><I><P><D><E><T><M><V><I><G><N><Y><R><T><Q><L><Y><D><K><Q><R><E><E><Y><Q><P><A><T><P><G><L><G><M><F><V><E><V><K><D><P><E><D><K><V><I><L><A><R><Q><Y><G><S><E><G><R... | Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific... | Q9BVK6 |
Q96IY1 | NSL1_HUMAN | Kinetochore-associated protein NSL1 homolog | Homo | <M><A><G><S><P><E><L><V><V><L><D><P><P><W><D><K><E><L><A><A><G><T><E><S><Q><A><L><V><S><A><T><P><R><E><D><F><R><V><R><C><T><S><K><R><A><V><T><E><M><L><Q><L><C><G><R><F><V><Q><K><L><G><D><A><L><P><E><E><I><R><E><P><A><L><R><D><A><Q><W><T><F><E><S><A><V><Q><E><N><I><S><I><N><G><Q><A><W><Q><E><A><S><D><N><C><F><M><D><S><D... | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<BOP> | Q96IY1 |
Q16572 | VACHT_HUMAN | Solute carrier family 18 member 3 | Homo | <M><E><S><A><E><P><A><G><Q><A><R><A><A><A><T><K><L><S><E><A><V><G><A><A><L><Q><E><P><R><R><Q><R><R><L><V><L><V><I><V><C><V><A><L><L><L><D><N><M><L><Y><M><V><I><V><P><I><V><P><D><Y><I><A><H><M><R><G><G><G><E><G><P><T><R><T><P><E><V><W><E><P><T><L><P><L><P><T><P><A><N><A><S><A><Y><T><A><N><T><S><A><S><P><T><A><A><W><P><A... | Involved in acetylcholine transport into synaptic vesicles.<BOP> | Q16572 |
O75023 | LIRB5_HUMAN | Leukocyte immunoglobulin-like receptor 8 | Homo | <M><T><L><T><L><S><V><L><I><C><L><G><L><S><V><G><P><R><T><C><V><Q><A><G><T><L><P><K><P><T><L><W><A><E><P><A><S><V><I><A><R><G><K><P><V><T><L><W><C><Q><G><P><L><E><T><E><E><Y><R><L><D><K><E><G><L><P><W><A><R><K><R><Q><N><P><L><E><P><G><A><K><A><K><F><H><I><P><S><T><V><Y><D><S><A><G><R><Y><R><C><Y><Y><E><T><P><A><G><W><S... | May act as receptor for class I MHC antigens.<BOP> | O75023 |
Q16082 | HSPB2_HUMAN | DMPK-binding protein | Homo | <M><S><G><R><S><V><P><H><A><H><P><A><T><A><E><Y><E><F><A><N><P><S><R><L><G><E><Q><R><F><G><E><G><L><L><P><E><E><I><L><T><P><T><L><Y><H><G><Y><Y><V><R><P><R><A><A><P><A><G><E><G><S><R><A><G><A><S><E><L><R><L><S><E><G><K><F><Q><A><F><L><D><V><S><H><F><T><P><D><E><V><T><V><R><T><V><D><N><L><L><E><V><S><A><R><H><P><Q><R><L... | May regulate the kinase DMPK.<BOP> | Q16082 |
Q49A26 | GLYR1_HUMAN | Putative oxidoreductase GLYR1 | Homo | <M><A><A><V><S><L><R><L><G><D><L><V><W><G><K><L><G><R><Y><P><P><W><P><G><K><I><V><N><P><P><K><D><L><K><K><P><R><G><K><K><C><F><F><V><K><F><F><G><T><E><D><H><A><W><I><K><V><E><Q><L><K><P><Y><H><A><H><K><E><E><M><I><K><I><N><K><G><K><R><F><Q><Q><A><V><D><A><V><E><E><F><L><R><R><A><K><G><K><D><Q><T><S><S><H><N><S><S><D><D... | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression . Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation . Recognizes and binds histone H3 without a preference for specific epigenetic ma... | Q49A26 |
H0YL14 | TM250_HUMAN | Herpes virus UL25-binding protein | Homo | <M><P><V><M><P><I><P><R><R><V><R><S><F><H><G><P><H><T><T><C><L><H><A><A><C><G><P><V><R><A><S><H><L><A><R><T><K><Y><N><N><F><D><V><Y><I><K><T><R><W><L><Y><G><F><I><R><F><L><L><Y><F><S><C><S><L><F><T><A><A><L><W><G><A><L><A><A><L><F><C><L><Q><Y><L><G><V><R><V><L><L><R><F><Q><R><K><L><S><V><L><L><L><L><L><G><R><R><R><V><D... | (Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation.<BOP> | H0YL14 |
O60684 | IMA7_HUMAN | Karyopherin subunit alpha-6 | Homo | <M><E><T><M><A><S><P><G><K><D><N><Y><R><M><K><S><Y><K><N><N><A><L><N><P><E><E><M><R><R><R><R><E><E><E><G><I><Q><L><R><K><Q><K><R><E><Q><Q><L><F><K><R><R><N><V><E><L><I><N><E><E><A><A><M><F><D><S><L><L><M><D><S><Y><V><S><S><T><T><G><E><S><V><I><T><R><E><M><V><E><M><L><F><S><D><D><S><D><L><Q><L><A><T><T><Q><K><F><R><K><L... | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repe... | O60684 |
P06881 | CALCA_HUMAN | Calcitonin gene-related peptide I | Homo | <M><G><F><Q><K><F><S><P><F><L><A><L><S><I><L><V><L><L><Q><A><G><S><L><H><A><A><P><F><R><S><A><L><E><S><S><P><A><D><P><A><T><L><S><E><D><E><A><R><L><L><L><A><A><L><V><Q><D><Y><V><Q><M><K><A><S><E><L><E><Q><E><Q><E><R><E><G><S><R><I><I><A><Q><K><R><A><C><D><T><A><T><C><V><T><H><R><L><A><G><L><L><S><R><S><G><G><V><V><K><N... | CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.<BOP> | P06881 |
P10301 | RRAS_HUMAN | p23 | Homo | <M><S><S><G><A><A><S><G><T><G><R><G><R><P><R><G><G><G><P><G><P><G><D><P><P><P><S><E><T><H><K><L><V><V><V><G><G><G><G><V><G><K><S><A><L><T><I><Q><F><I><Q><S><Y><F><V><S><D><Y><D><P><T><I><E><D><S><Y><T><K><I><C><S><V><D><G><I><P><A><R><L><D><I><L><D><T><A><G><Q><E><E><F><G><A><M><R><E><Q><Y><M><R><A><G><H><G><F><L><L><V... | Regulates the organization of the actin cytoskeleton . With OSPBL3, modulates integrin beta-1 (ITGB1) activity .<BOP> | P10301 |
Q68D86 | C102B_HUMAN | Coiled-coil domain-containing protein 102B | Homo | <M><N><L><D><S><I><H><R><L><I><E><E><T><Q><I><F><Q><M><Q><Q><S><S><I><K><S><R><G><D><M><V><A><P><A><S><P><P><R><D><T><C><N><T><C><F><P><L><H><G><L><Q><S><H><A><A><H><N><F><C><A><H><S><Y><N><T><N><K><W><D><I><C><E><E><L><R><L><R><E><L><E><E><V><K><A><R><A><A><Q><M><E><K><T><M><R><W><W><S><D><C><T><A><N><W><R><E><K><W><S... | During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion . During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation . Contributes to CROCC/rootletin filament formation .<BOP> | Q68D86 |
O75935 | DCTN3_HUMAN | Dynactin complex subunit 22 kDa subunit | Homo | <M><A><G><L><T><D><L><Q><R><L><Q><A><R><V><E><E><L><E><R><W><V><Y><G><P><G><G><A><R><G><S><R><K><V><A><D><G><L><V><K><V><Q><V><A><L><G><N><I><S><S><K><R><E><R><V><K><I><L><Y><K><K><I><E><D><L><I><K><Y><L><D><P><E><Y><I><D><R><I><A><I><P><D><A><S><K><L><Q><F><I><L><A><E><E><Q><F><I><L><S><Q><V><A><L><L><E><Q><V><N><A><L... | Together with dynein may be involved in spindle assembly and cytokinesis.<BOP> | O75935 |
Q9HCC0 | MCCB_HUMAN | 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta | Homo | <M><W><A><V><L><R><L><A><L><R><P><C><A><R><A><S><P><A><G><P><R><A><Y><H><G><D><S><V><A><S><L><G><T><Q><P><D><L><G><S><A><L><Y><Q><E><N><Y><K><Q><M><K><A><L><V><N><Q><L><H><E><R><V><E><H><I><K><L><G><G><G><E><K><A><R><A><L><H><I><S><R><G><K><L><L><P><R><E><R><I><D><N><L><I><D><P><G><S><P><F><L><E><L><S><Q><F><A><G><Y><Q... | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.<BOP> | Q9HCC0 |
Q16695 | H31T_HUMAN | Histone H3.4 | Homo | <M><A><R><T><K><Q><T><A><R><K><S><T><G><G><K><A><P><R><K><Q><L><A><T><K><V><A><R><K><S><A><P><A><T><G><G><V><K><K><P><H><R><Y><R><P><G><T><V><A><L><R><E><I><R><R><Y><Q><K><S><T><E><L><L><I><R><K><L><P><F><Q><R><L><M><R><E><I><A><Q><D><F><K><T><D><L><R><F><Q><S><S><A><V><M><A><L><Q><E><A><C><E><S><Y><L><V><G><L><F><E><D... | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated v... | Q16695 |
A0A589 | TVB43_HUMAN | T cell receptor beta variable 4-3 | Homo | <M><G><C><R><L><L><C><C><A><V><L><C><L><L><G><A><V><P><M><E><T><G><V><T><Q><T><P><R><H><L><V><M><G><M><T><N><K><K><S><L><K><C><E><Q><H><L><G><H><N><A><M><Y><W><Y><K><Q><S><A><K><K><P><L><E><L><M><F><V><Y><S><L><E><E><R><V><E><N><N><S><V><P><S><R><F><S><P><E><C><P><N><S><S><H><L><F><L><H><L><H><T><L><Q><P><E><D><S><A><L... | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (p... | A0A589 |
P34981 | TRFR_HUMAN | Thyroliberin receptor | Homo | <M><E><N><E><T><V><S><E><L><N><Q><T><Q><L><Q><P><R><A><V><V><A><L><E><Y><Q><V><V><T><I><L><L><V><L><I><I><C><G><L><G><I><V><G><N><I><M><V><V><L><V><V><M><R><T><K><H><M><R><T><P><T><N><C><Y><L><V><S><L><A><V><A><D><L><M><V><L><V><A><A><G><L><P><N><I><T><D><S><I><Y><G><S><W><V><Y><G><Y><V><G><C><L><C><I><T><Y><L><Q><Y><L... | Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<BOP> | P34981 |
Q5JTV8 | TOIP1_HUMAN | Lamin-associated protein 1B | Homo | <M><A><G><D><G><R><R><A><E><A><V><R><E><G><W><G><V><Y><V><T><P><R><A><P><I><R><E><G><R><G><R><L><A><P><Q><N><G><G><S><S><D><A><P><A><Y><R><T><P><P><S><R><Q><G><R><R><E><V><R><F><S><D><E><P><P><E><V><Y><G><D><F><E><P><L><V><A><K><E><R><S><P><V><G><K><R><T><R><L><E><E><F><R><S><D><S><A><K><E><E><V><R><E><S><A><Y><Y><L><R... | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.<BOP> | Q5JTV8 |
P0DP03 | HVC05_HUMAN | Immunoglobulin heavy variable 3-30-5 | Homo | <M><E><F><G><L><S><W><V><F><L><V><A><L><L><R><G><V><Q><C><Q><V><Q><L><V><E><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><G><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><I><S><Y><D><G><S><N><K><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A... | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | P0DP03 |
Q9GZM6 | OR8D2_HUMAN | Olfactory receptor-like protein JCG2 | Homo | <M><A><T><S><N><H><S><S><G><A><E><F><I><L><A><G><L><T><Q><R><P><E><L><Q><L><P><L><F><L><L><F><L><G><I><Y><V><V><T><V><V><G><N><L><G><M><I><F><L><I><A><L><S><S><Q><L><Y><P><P><V><Y><Y><F><L><S><H><L><S><F><I><D><L><C><Y><S><S><V><I><T><P><K><M><L><V><N><F><V><P><E><E><N><I><I><S><F><L><E><C><I><T><Q><L><Y><F><F><L><I><F... | Odorant receptor (Potential). May be involved in taste perception.<BOP> | Q9GZM6 |
O75333 | TBX10_HUMAN | T-box transcription factor TBX10 | Homo | <M><A><A><F><L><S><A><G><L><G><I><L><A><P><S><E><T><Y><P><L><P><T><T><S><S><G><W><E><P><R><L><G><S><P><F><P><S><G><P><C><T><S><S><T><G><A><Q><A><V><A><E><P><T><G><Q><G><P><K><N><P><R><V><S><R><V><T><V><Q><L><E><M><K><P><L><W><E><E><F><N><Q><L><G><T><E><M><I><V><T><K><A><G><R><R><M><F><P><P><F><Q><V><K><I><L><G><M><D><S... | Probable transcriptional regulator involved in developmental processes.<BOP> | O75333 |
P83876 | TXN4A_HUMAN | Thioredoxin-like U5 snRNP protein U5-15kD | Homo | <M><S><Y><M><L><P><H><L><H><N><G><W><Q><V><D><Q><A><I><L><S><E><E><D><R><V><V><V><I><R><F><G><H><D><W><D><P><T><C><M><K><M><D><E><V><L><Y><S><I><A><E><K><V><K><N><F><A><V><I><Y><L><V><D><I><T><E><V><P><D><F><N><K><M><Y><E><L><Y><D><P><C><T><V><M><F><F><F><R><N><K><H><I><M><I><D><L><G><T><G><N><N><N><K><I><N><W><A><M><E... | Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).<BOP> | P83876 |
Q9GZU1 | MCLN1_HUMAN | Transient receptor potential channel mucolipin 1 | Homo | <M><T><A><P><A><G><P><R><G><S><E><T><E><R><L><L><T><P><N><P><G><Y><G><T><Q><A><G><P><S><P><A><P><P><T><P><P><E><E><E><D><L><R><R><R><L><K><Y><F><F><M><S><P><C><D><K><F><R><A><K><G><R><K><P><C><K><L><M><L><Q><V><V><K><I><L><V><V><T><V><Q><L><I><L><F><G><L><S><N><Q><L><A><V><T><F><R><E><E><N><T><I><A><F><R><H><L><F><L><L... | May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates ... | Q9GZU1 |
O15498 | YKT6_HUMAN | Synaptobrevin homolog YKT6 | Homo | <M><K><L><Y><S><L><S><V><L><Y><K><G><E><A><K><V><V><L><L><K><A><A><Y><D><V><S><S><F><S><F><F><Q><R><S><S><V><Q><E><F><M><T><F><T><S><Q><L><I><V><E><R><S><S><K><G><T><R><A><S><V><K><E><Q><D><Y><L><C><H><V><Y><V><R><N><D><S><L><A><G><V><V><I><A><D><N><E><Y><P><S><R><V><A><F><T><L><L><E><K><V><L><D><E><F><S><K><Q><V><D><R... | Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as pa... | O15498 |
Q9Y617 | SERC_HUMAN | Phosphohydroxythreonine aminotransferase | Homo | <M><D><A><P><R><Q><V><V><N><F><G><P><G><P><A><K><L><P><H><S><V><L><L><E><I><Q><K><E><L><L><D><Y><K><G><V><G><I><S><V><L><E><M><S><H><R><S><S><D><F><A><K><I><I><N><N><T><E><N><L><V><R><E><L><L><A><V><P><D><N><Y><K><V><I><F><L><Q><G><G><G><C><G><Q><F><S><A><V><P><L><N><L><I><G><L><K><A><G><R><C><A><D><Y><V><V><T><G><A><W... | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<BOP> | Q9Y617 |
P33260 | CP2CI_HUMAN | Cytochrome P450-6b/29c | Homo | <M><D><P><A><V><A><L><V><L><C><L><S><C><L><F><L><L><S><L><W><R><Q><S><S><G><R><G><R><L><P><S><G><P><T><P><L><P><I><I><G><N><I><L><Q><L><D><V><K><D><M><S><K><S><L><T><N><F><S><K><V><Y><G><P><V><F><T><V><Y><F><G><L><K><P><I><V><V><L><H><G><Y><E><A><V><K><E><A><L><I><D><H><G><E><E><F><S><G><R><G><S><F><P><V><A><E><K><V><N... | A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two ele... | P33260 |
D6R901 | U17LL_HUMAN | Ubiquitin carboxyl-terminal hydrolase 17-like protein 21 | Homo | <M><E><E><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><N><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y... | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP> | D6R901 |
Q9UNW8 | GP132_HUMAN | G2 accumulation protein | Homo | <M><C><P><M><L><L><K><N><G><Y><N><G><N><A><T><P><V><T><T><T><A><P><W><A><S><L><G><L><S><A><K><T><C><N><N><V><S><F><E><E><S><R><I><V><L><V><V><V><Y><S><A><V><C><T><L><G><V><P><A><N><C><L><T><A><W><L><A><L><L><Q><V><L><Q><G><N><V><L><A><V><Y><L><L><C><L><A><L><C><E><L><L><Y><T><G><T><L><P><L><W><V><I><Y><I><R><N><Q><H><R... | May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxi... | Q9UNW8 |
Q8NG85 | OR2L3_HUMAN | Olfactory receptor 2L3 | Homo | <M><E><N><Y><N><Q><T><S><T><D><F><I><L><L><G><F><F><P><P><S><R><I><G><L><F><L><F><I><L><I><V><F><I><F><L><M><A><L><I><G><N><L><S><M><I><L><L><I><F><L><D><T><H><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><I><D><L><N><Y><I><S><T><I><V><P><K><M><A><S><D><F><L><S><G><N><K><S><I><S><F><T><G><C><G><I><Q><S><F><F><F><S><A><L><G... | Odorant receptor.<BOP> | Q8NG85 |
Q6DKK2 | TTC19_HUMAN | Tetratricopeptide repeat protein 19, mitochondrial | Homo | <M><F><R><L><L><S><W><S><L><G><R><G><F><L><R><A><A><G><R><R><C><R><G><C><S><A><R><L><L><P><G><L><A><G><G><P><G><P><E><V><Q><V><P><P><S><R><V><A><P><H><G><R><G><P><G><L><L><P><L><L><A><A><L><A><W><F><S><R><P><A><A><A><E><E><E><E><Q><Q><G><A><D><G><A><A><A><E><D><G><A><D><E><A><E><A><E><I><I><Q><L><L><K><R><A><K><L><S><I... | Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 . Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and wh... | Q6DKK2 |
Q9Y333 | LSM2_HUMAN | snRNP core Sm-like protein Sm-x5 | Homo | <M><L><F><Y><S><F><F><K><S><L><V><G><K><D><V><V><V><E><L><K><N><D><L><S><I><C><G><T><L><H><S><V><D><Q><Y><L><N><I><K><L><T><D><I><S><V><T><D><P><E><K><Y><P><H><M><L><S><V><K><N><C><F><I><R><G><S><V><V><R><Y><V><Q><L><P><A><D><E><V><D><T><Q><L><L><Q><D><A><A><R><K><E><A><L><Q><Q><K><Q> | Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA .<BOP> | Q9Y333 |
P80370 | DLK1_HUMAN | Fetal antigen 1 | Homo | <M><T><A><T><E><A><L><L><R><V><L><L><L><L><L><A><F><G><H><S><T><Y><G><A><E><C><F><P><A><C><N><P><Q><N><G><F><C><E><D><D><N><V><C><R><C><Q><P><G><W><Q><G><P><L><C><D><Q><C><V><T><S><P><G><C><L><H><G><L><C><G><E><P><G><Q><C><I><C><T><D><G><W><D><G><E><L><C><D><R><D><V><R><A><C><S><S><A><P><C><A><N><N><R><T><C><V><S><L><D... | May have a role in neuroendocrine differentiation.<BOP> | P80370 |
A0A075B6S5 | KV127_HUMAN | Immunoglobulin kappa variable 1-27 | Homo | <M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><P><D><T><R><C><D><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><S><N><Y><L><A><W><Y><Q><Q><K><P><G><K><V><P><K><L><L><I><Y><A><A><S><T><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><V><A><T... | V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | A0A075B6S5 |
P08100 | OPSD_HUMAN | Opsin-2 | Homo | <M><N><G><T><E><G><P><N><F><Y><V><P><F><S><N><A><T><G><V><V><R><S><P><F><E><Y><P><Q><Y><Y><L><A><E><P><W><Q><F><S><M><L><A><A><Y><M><F><L><L><I><V><L><G><F><P><I><N><F><L><T><L><Y><V><T><V><Q><H><K><K><L><R><T><P><L><N><Y><I><L><L><N><L><A><V><A><D><L><F><M><V><L><G><G><F><T><S><T><L><Y><T><S><L><H><G><Y><F><V><F><G><P... | Photoreceptor required for image-forming vision at low light intensity . Required for photoreceptor cell viability after birth . Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins . Subsequent receptor phosphorylati... | P08100 |
Q8N108 | MIER1_HUMAN | Mesoderm induction early response protein 1 | Homo | <M><A><E><P><S><V><E><S><S><S><P><G><G><S><A><T><S><D><D><H><E><F><D><P><S><A><D><M><L><V><H><D><F><D><D><E><R><T><L><E><E><E><E><M><M><E><G><E><T><N><F><S><S><E><I><E><D><L><A><R><E><G><D><M><P><I><H><E><L><L><S><L><Y><G><Y><G><S><T><V><R><L><P><E><E><D><E><E><E><E><E><E><E><E><E><G><E><D><D><E><D><A><D><N><D><D><N><S... | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.<BOP> | Q8N108 |
Q9BTE6 | AASD1_HUMAN | Alanyl-tRNA synthetase domain-containing protein 1 | Homo | <M><A><F><W><C><Q><R><D><S><Y><A><R><E><F><T><T><T><V><V><S><C><C><P><A><E><L><Q><T><E><G><S><N><G><K><K><E><V><L><S><G><F><Q><V><V><L><E><D><T><V><L><F><P><E><G><G><G><Q><P><D><D><R><G><T><I><N><D><I><S><V><L><R><V><T><R><R><G><E><Q><A><D><H><F><T><Q><T><P><L><D><P><G><S><Q><V><L><V><R><V><D><W><E><R><R><F><D><H><M><Q... | Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).<BOP> | Q9BTE6 |
Q96T68 | SETB2_HUMAN | SET domain bifurcated 2 | Homo | <M><G><E><K><N><G><D><A><K><T><F><W><M><E><L><E><D><D><G><K><V><D><F><I><F><E><Q><V><Q><N><V><L><Q><S><L><K><Q><K><I><K><D><G><S><A><T><N><K><E><Y><I><Q><A><M><I><L><V><N><E><A><T><I><I><N><S><S><T><S><I><K><G><A><S><Q><K><E><V><N><A><Q><S><S><D><P><M><P><V><T><Q><K><E><Q><E><N><K><S><N><A><F><P><S><T><S><C><E><N><S><F... | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to... | Q96T68 |
Q92925 | SMRD2_HUMAN | BRG1-associated factor 60B | Homo | <M><S><G><R><G><A><G><G><F><P><L><P><P><L><S><P><G><G><G><A><V><A><A><A><L><G><A><P><P><P><P><A><G><P><G><M><L><P><G><P><A><L><R><G><P><G><P><A><G><G><V><G><G><P><G><A><A><A><F><R><P><M><G><P><A><G><P><A><A><Q><Y><Q><R><P><G><M><S><P><G><N><R><M><P><M><A><G><L><Q><V><G><P><P><A><G><S><P><F><G><A><A><A><P><L><R><P><G><M... | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-... | Q92925 |
P21757 | MSRE_HUMAN | Scavenger receptor class A member 1 | Homo | <M><E><Q><W><D><H><F><H><N><Q><Q><E><D><T><D><S><C><S><E><S><V><K><F><D><A><R><S><M><T><A><L><L><P><P><N><P><K><N><S><P><S><L><Q><E><K><L><K><S><F><K><A><A><L><I><A><L><Y><L><L><V><F><A><V><L><I><P><L><I><G><I><V><A><A><Q><L><L><K><W><E><T><K><N><C><S><V><S><S><T><N><A><N><D><I><T><Q><S><L><T><G><K><G><N><D><S><E><E><E... | Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) . Isoform III does not internalize a... | P21757 |
A6NDE4 | RBY1B_HUMAN | RNA-binding motif protein, Y chromosome, family 1 member B | Homo | <M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G... | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.<BOP> | A6NDE4 |
Q9UK97 | FBX9_HUMAN | Renal carcinoma antigen NY-REN-57 | Homo | <M><P><D><I><I><W><V><F><P><P><Q><A><E><A><E><E><D><C><H><S><D><T><V><R><A><D><D><D><E><E><N><E><S><P><A><E><T><D><L><Q><A><Q><L><Q><M><F><R><A><Q><W><M><F><E><L><A><P><G><V><S><S><S><N><L><E><N><R><P><C><R><A><A><R><G><S><L><Q><K><T><S><A><D><T><K><G><K><Q><E><Q><A><K><E><E><K><A><R><E><L><F><L><K><A><V><E><E><E><Q><N... | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and T... | Q9UK97 |
Q9BUN5 | CC28B_HUMAN | Coiled-coil domain-containing protein 28B | Homo | <M><D><D><K><K><K><K><R><S><P><K><P><C><L><A><Q><P><A><Q><A><P><G><T><L><R><R><V><P><V><P><T><S><H><S><G><S><L><A><L><G><L><P><H><L><P><S><P><K><Q><R><A><K><F><K><R><V><G><K><E><K><C><R><P><V><L><A><G><G><G><S><G><S><A><G><T><P><L><Q><H><S><F><L><T><E><V><T><D><V><Y><E><M><E><G><G><L><L><N><L><L><N><D><F><H><S><G><R><L... | Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.<BOP> | Q9BUN5 |
Q10587 | TEF_HUMAN | Thyrotroph embryonic factor | Homo | <M><S><D><A><G><G><G><K><K><P><P><V><D><P><Q><A><G><P><G><P><G><P><G><R><A><A><G><E><R><G><L><S><G><S><F><P><L><V><L><K><K><L><M><E><N><P><P><R><E><A><R><L><D><K><E><K><G><K><E><K><L><E><E><D><E><A><A><A><A><S><T><M><A><V><S><A><S><L><M><P><P><I><W><D><K><T><I><P><Y><D><G><E><S><F><H><L><E><Y><M><D><L><D><E><F><L><L><E... | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.<BOP> | Q10587 |
O14957 | QCR10_HUMAN | Ubiquinol-cytochrome c reductase complex 6.4 kDa protein | Homo | <M><V><T><R><F><L><G><P><R><Y><R><E><L><V><K><N><W><V><P><T><A><Y><T><W><G><A><V><G><A><V><G><L><V><W><A><T><D><W><R><L><I><L><D><W><V><P><Y><I><N><G><K><F><K><K><D><N> | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidor... | O14957 |
Q969J5 | I22R2_HUMAN | ZcytoR16 | Homo | <M><M><P><K><H><C><F><L><G><F><L><I><S><F><F><L><T><G><V><A><G><T><Q><S><T><H><E><S><L><K><P><Q><R><V><Q><F><Q><S><R><N><F><H><N><I><L><Q><W><Q><P><G><R><A><L><T><G><N><S><S><V><Y><F><V><Q><Y><K><I><M><F><S><C><S><M><K><S><S><H><Q><K><P><S><G><C><W><Q><H><I><S><C><N><F><P><G><C><R><T><L><A><K><Y><G><Q><R><Q><W><K><N><K... | Isoform 1 may play a role in establishing and maintaining successful pregnancy.<BOP> | Q969J5 |
Q9NR11 | ZN302_HUMAN | Zinc finger protein 327 | Homo | <M><S><Q><V><T><F><S><D><V><A><I><D><F><S><H><E><E><W><A><C><L><D><S><A><Q><R><D><L><Y><K><D><V><M><V><Q><N><Y><E><N><L><V><S><V><G><L><S><V><T><K><P><Y><V><I><M><L><L><E><D><G><K><E><P><W><M><M><E><K><K><L><S><K><A><Y><P><F><P><L><S><H><S><V><P><A><S><V><N><F><G><F><S><A><L><F><E><H><C><S><E><V><T><E><I><F><E><L><S><E... | May be involved in transcriptional regulation.<BOP> | Q9NR11 |
P01850 | TRBC1_HUMAN | T cell receptor beta constant 1 | Homo | <D><L><N><K><V><F><P><P><E><V><A><V><F><E><P><S><E><A><E><I><S><H><T><Q><K><A><T><L><V><C><L><A><T><G><F><F><P><D><H><V><E><L><S><W><W><V><N><G><K><E><V><H><S><G><V><S><T><D><P><Q><P><L><K><E><Q><P><A><L><N><D><S><R><Y><C><L><S><S><R><L><R><V><S><A><T><F><W><Q><N><P><R><N><H><F><R><C><Q><V><Q><F><Y><G><L><S><E><N><D><E... | Constant region of T cell receptor (TR) beta chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells ... | P01850 |
Q15818 | NPTX1_HUMAN | Neuronal pentraxin I | Homo | <M><P><A><G><R><A><A><R><T><C><A><L><L><A><L><C><L><L><G><A><G><A><Q><D><F><G><P><T><R><F><I><C><T><S><V><P><V><D><A><D><M><C><A><A><S><V><A><A><G><G><A><E><E><L><R><S><S><V><L><Q><L><R><E><T><V><L><Q><Q><K><E><T><I><L><S><Q><K><E><T><I><R><E><L><T><A><K><L><G><R><C><E><S><Q><S><T><L><D><P><G><A><G><E><A><R><A><G><G><G... | May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.<BOP> | Q15818 |
Q04844 | ACHE_HUMAN | Acetylcholine receptor subunit epsilon | Homo | <M><A><R><A><P><L><G><V><L><L><L><L><G><L><L><G><R><G><V><G><K><N><E><E><L><R><L><Y><H><H><L><F><N><N><Y><D><P><G><S><R><P><V><R><E><P><E><D><T><V><T><I><S><L><K><V><T><L><T><N><L><I><S><L><N><E><K><E><E><T><L><T><T><S><V><W><I><G><I><D><W><Q><D><Y><R><L><N><Y><S><K><D><D><F><G><G><I><E><T><L><R><V><P><S><E><L><V><W><L... | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP> | Q04844 |
P46527 | CDN1B_HUMAN | p27Kip1 | Homo | <M><S><N><V><R><V><S><N><G><S><P><S><L><E><R><M><D><A><R><Q><A><E><H><P><K><P><S><A><C><R><N><L><F><G><P><V><D><H><E><E><L><T><R><D><L><E><K><H><C><R><D><M><E><E><A><S><Q><R><K><W><N><F><D><F><Q><N><H><K><P><L><E><G><K><Y><E><W><Q><E><V><E><K><G><S><L><P><E><F><Y><Y><R><P><P><R><P><P><K><G><A><C><K><V><P><A><Q><E><S><Q... | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the as... | P46527 |
Q6P4I2 | WDR73_HUMAN | WD repeat-containing protein 73 | Homo | <M><D><P><G><D><D><W><L><V><E><S><L><R><L><Y><Q><D><F><Y><A><F><D><L><S><G><A><T><R><V><L><E><W><I><D><D><K><G><V><F><V><A><G><Y><E><S><L><K><K><N><E><I><L><H><L><K><L><P><L><R><L><S><V><K><E><N><K><G><L><F><P><E><R><D><F><K><V><R><H><G><G><F><S><D><R><S><I><F><D><L><K><H><V><P><H><T><R><L><L><V><T><S><G><L><P><G><C><Y... | May play a role in the regulation of microtubule organization and dynamics .<BOP> | Q6P4I2 |
Q92575 | UBXN4_HUMAN | UBX domain-containing protein 2 | Homo | <M><L><W><F><Q><G><A><I><P><A><A><I><A><T><A><K><R><S><G><A><V><F><V><V><F><V><A><G><D><D><E><Q><S><T><Q><M><A><A><S><W><E><D><D><K><V><T><E><A><S><S><N><S><F><V><A><I><K><I><D><T><K><S><E><A><C><L><Q><F><S><Q><I><Y><P><V><V><C><V><P><S><S><F><F><I><G><D><S><G><I><P><L><E><V><I><A><G><S><V><S><A><D><E><L><V><T><R><I><H... | Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD .<BOP> | Q92575 |
Q96LB3 | IFT74_HUMAN | Coiled-coil domain-containing protein 2 | Homo | <M><A><S><N><H><K><S><S><A><A><R><P><V><S><R><G><G><V><G><L><T><G><R><P><P><S><G><I><R><P><L><S><G><N><I><R><V><A><T><A><M><P><P><G><T><A><R><P><G><S><R><G><C><P><I><G><T><G><G><V><L><S><S><Q><I><K><V><A><H><R><P><V><T><Q><Q><G><L><T><G><M><K><T><G><T><K><G><P><Q><R><Q><I><L><D><K><S><Y><Y><L><G><L><L><R><S><K><I><S><E... | Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium . Binds beta-tubulin via its basic region . Required for ciliogenesis . Essential for flagellogenesis during spermatogenesis .<BOP> | Q96LB3 |
O00746 | NDKM_HUMAN | nm23-H4 | Homo | <M><G><G><L><F><W><R><S><A><L><R><G><L><R><C><G><P><R><A><P><G><P><S><L><L><V><R><H><G><S><G><G><P><S><W><T><R><E><R><T><L><V><A><V><K><P><D><G><V><Q><R><R><L><V><G><D><V><I><Q><R><F><E><R><R><G><F><T><L><V><G><M><K><M><L><Q><A><P><E><S><V><L><A><E><H><Y><Q><D><L><R><R><K><P><F><Y><P><A><L><I><R><Y><M><S><S><G><P><V><V... | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in reg... | O00746 |
P26441 | CNTF_HUMAN | Ciliary neurotrophic factor | Homo | <M><A><F><T><E><H><S><P><L><T><P><H><R><R><D><L><C><S><R><S><I><W><L><A><R><K><I><R><S><D><L><T><A><L><T><E><S><Y><V><K><H><Q><G><L><N><K><N><I><N><L><D><S><A><D><G><M><P><V><A><S><T><D><Q><W><S><E><L><T><E><A><E><R><L><Q><E><N><L><Q><A><Y><R><T><F><H><V><L><L><A><R><L><L><E><D><Q><Q><V><H><F><T><P><T><E><G><D><F><H><Q... | CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.<BOP> | P26441 |
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