Datasets:
yangzhang33
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Prot2Text-Diff-HUMAN-func256-seq768

Dataset card Data Studio Files
xet
Community
1
accession
stringlengths
6
10
name
stringlengths
8
11
Full Name
stringlengths
2
102
⌀
taxon
stringclasses
1 value
sequence
stringlengths
48
2.3k
function
stringlengths
15
1.34k
AlphaFoldDB
stringlengths
6
10
Q8NBJ4
GOLM1_HUMAN
Golgi phosphoprotein 2
Homo
<M><M><G><L><G><N><G><R><R><S><M><K><S><P><P><L><V><L><A><A><L><V><A><C><I><I><V><L><G><F><N><Y><W><I><A><S><S><R><S><V><D><L><Q><T><R><I><M><E><L><E><G><R><V><R><R><A><A><A><E><R><G><A><V><E><L><K><K><N><E><F><Q><G><E><L><E><K><Q><R><E><Q><L><D><K><I><Q><S><S><H><N><F><Q><L><E><S><V><N><K><L><Y><Q><D><E><K><A><V><L><V><N><N><I><T><T><G><E><R><L><I><R><V><L><Q><D><Q><L><K><T><L><Q><R><N><Y><G><R><L><Q><Q><D><V><L><Q><F><Q><K><N><Q><T><N><L><E><R><K><F><S><Y><D><L><S><Q><C><I><N><Q><M><K><E><V><K><E><Q><C><E><E><R><I><E><E><V><T><K><K><G><N><E><A><V><A><S><R><D><L><S><E><N><N><D><Q><R><Q><Q><L><Q><A><L><S><E><P><Q><P><R><L><Q><A><A><G><L><P><H><T><E><V><P><Q><G><K><G><N><V><L><G><N><S><K><S><Q><T><P><A><P><S><S><E><V><V><L><D><S><K><R><Q><V><E><K><E><E><T><N><E><I><Q><V><V><N><E><E><P><Q><R><D><R><L><P><Q><E><P><G><R><E><Q><V><V><E><D><R><P><V><G><G><R><G><F><G><G><A><G><E><L><G><Q><T><P><Q><V><Q><A><A><L><S><V><S><Q><E><N><P><E><M><E><G><P><E><R><D><Q><L><V><I><P><D><G><Q><E><E><E><Q><E><A><A><G><E><G><R><N><Q><Q><K><L><R><G><E><D><D><Y><N><M><D><E><N><E><A><E><S><E><T><D><K><Q><A><A><L><A><G><N><D><R><N><I><D><V><F><N><V><E><D><Q><K><R><D><T><I><N><L><L><D><Q><R><E><K><R><N><H><T><L>
Unknown. Cellular response protein to viral infection.<BOP>
Q8NBJ4
Q86VF5
MOGT3_HUMAN
Monoacylglycerol O-acyltransferase 3
Homo
<M><G><V><A><T><T><L><Q><P><P><T><T><S><K><T><L><Q><K><Q><H><L><E><A><V><G><A><Y><Q><Y><V><L><T><F><L><F><M><G><P><F><F><S><L><L><V><F><V><L><L><F><T><S><L><W><P><F><S><V><F><Y><L><V><W><L><Y><V><D><W><D><T><P><N><Q><G><G><R><R><S><E><W><I><R><N><R><A><I><W><R><Q><L><R><D><Y><Y><P><V><K><L><V><K><T><A><E><L><P><P><D><R><N><Y><V><L><G><A><H><P><H><G><I><M><C><T><G><F><L><C><N><F><S><T><E><S><N><G><F><S><Q><L><F><P><G><L><R><P><W><L><A><V><L><A><G><L><F><Y><L><P><V><Y><R><D><Y><I><M><S><F><G><L><C><P><V><S><R><Q><S><L><D><F><I><L><S><Q><P><Q><L><G><Q><A><V><V><I><M><V><G><G><A><H><E><A><L><Y><S><V><P><G><E><H><C><L><T><L><Q><K><R><K><G><F><V><R><L><A><L><R><H><G><A><S><L><V><P><V><Y><S><F><G><E><N><D><I><F><R><L><K><A><F><A><T><G><S><W><Q><H><W><C><Q><L><T><F><K><K><L><M><G><F><S><P><C><I><F><W><G><R><G><L><F><S><A><T><S><W><G><L><L><P><F><A><V><P><I><T><T><V><V><G><R><P><I><P><V><P><Q><R><L><H><P><T><E><E><E><V><N><H><Y><H><A><L><Y><M><T><A><L><E><Q><L><F><E><E><H><K><E><S><C><G><V><P><A><S><T><C><L><T><F><I>
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) .<BOP>
Q86VF5
Q14061
COX17_HUMAN
Cytochrome c oxidase copper chaperone
Homo
<M><P><G><L><V><D><S><N><P><A><P><P><E><S><Q><E><K><K><P><L><K><P><C><C><A><C><P><E><T><K><K><A><R><D><A><C><I><I><E><K><G><E><E><H><C><G><H><L><I><E><A><H><K><E><C><M><R><A><L><G><F><K><I>
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).<BOP>
Q14061
P02743
SAMP_HUMAN
Serum amyloid P-component(1-203)
Homo
<M><N><K><P><L><L><W><I><S><V><L><T><S><L><L><E><A><F><A><H><T><D><L><S><G><K><V><F><V><F><P><R><E><S><V><T><D><H><V><N><L><I><T><P><L><E><K><P><L><Q><N><F><T><L><C><F><R><A><Y><S><D><L><S><R><A><Y><S><L><F><S><Y><N><T><Q><G><R><D><N><E><L><L><V><Y><K><E><R><V><G><E><Y><S><L><Y><I><G><R><H><K><V><T><S><K><V><I><E><K><F><P><A><P><V><H><I><C><V><S><W><E><S><S><S><G><I><A><E><F><W><I><N><G><T><P><L><V><K><K><G><L><R><Q><G><Y><F><V><E><A><Q><P><K><I><V><L><G><Q><E><Q><D><S><Y><G><G><K><F><D><R><S><Q><S><F><V><G><E><I><G><D><L><Y><M><W><D><S><V><L><P><P><E><N><I><L><S><A><Y><Q><G><T><P><L><P><A><N><I><L><D><W><Q><A><L><N><Y><E><I><R><G><Y><V><I><I><K><P><L><V><W><V>
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.<BOP>
P02743
Q8NGY0
O10X1_HUMAN
Olfactory receptor OR1-14
Homo
<M><V><L><N><V><Y><C><C><F><F><Q><I><S><D><I><Q><T><M><K><I><N><Q><T><I><L><K><E><F><I><L><V><G><F><S><V><Y><P><H><V><Q><T><F><L><F><V><V><F><F><C><L><Y><L><L><T><L><A><G><N><L><I><I><M><G><L><T><W><V><D><R><S><L><H><T><P><M><Y><L><F><L><S><A><L><S><F><S><E><T><C><Y><T><L><T><I><V><P><K><M><L><E><D><L><L><A><K><D><R><S><I><S><V><T><G><C><S><L><Q><M><C><F><F><L><G><L><G><G><T><N><C><I><I><L><T><L><M><G><Y><D><R><F><L><A><I><C><N><P><L><R><Y><P><L><L><M><T><N><I><V><C><G><Q><L><V><A><S><A><C><T><A><G><F><F><I><S><L><T><E><T><A><L><I><F><R><D><S><F><C><R><P><N><L><V><K><H><F><F><C><H><M><L><A><V><I><R><L><S><C><I><D><S><N><H><T><E><F><I><I><T><L><I><S><V><S><G><L><L><G><T><L><L><L><I><I><L><T><D><V><F><I><I><S><T><V><L><R><I><P><S><A><E><G><K><Q><K><A><F><T><T><C><A><S><H><L><T><V><V><I><I><H><F><G><F><A><S><I><V><Y><L><K><P><E><A><S><G><D><D><T><L><I><A><V><P><Y><T><V><I><T><P><F><L><S><P><I><I><F><S><L><R><N><K><D><M><K><N><A><F><R><R><M><M><G><N><T><V><A><L><K><K>
Odorant receptor.<BOP>
Q8NGY0
P42766
RL35_HUMAN
Large ribosomal subunit protein uL29
Homo
<M><A><K><I><K><A><R><D><L><R><G><K><K><K><E><E><L><L><K><Q><L><D><D><L><K><V><E><L><S><Q><L><R><V><A><K><V><T><G><G><A><A><S><K><L><S><K><I><R><V><V><R><K><S><I><A><R><V><L><T><V><I><N><Q><T><Q><K><E><N><L><R><K><F><Y><K><G><K><K><Y><K><P><L><D><L><R><P><K><K><T><R><A><M><R><R><R><L><N><K><H><E><E><N><L><K><T><K><K><Q><Q><R><K><E><R><L><Y><P><L><R><K><Y><A><V><K><A>
Component of the large ribosomal subunit . The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell .<BOP>
P42766
Q8IZ81
ELMD2_HUMAN
ELMO domain-containing protein 2
Homo
<M><F><I><S><L><W><E><F><F><Y><G><H><F><F><R><F><W><M><K><W><L><L><R><Q><M><T><G><K><C><E><L><Q><R><I><F><D><T><Y><V><G><A><Q><R><T><H><R><I><E><N><S><L><T><Y><S><K><N><K><V><L><Q><K><A><T><H><V><V><Q><S><E><V><D><K><Y><V><D><D><I><M><K><E><K><N><I><N><P><E><K><D><A><S><F><K><I><C><M><K><M><C><L><L><Q><I><T><G><Y><K><Q><L><Y><L><D><V><E><S><V><R><K><R><P><Y><D><S><D><N><L><Q><H><E><E><L><L><M><K><L><W><N><L><L><M><P><T><K><K><L><N><A><R><I><S><K><Q><W><A><E><I><G><F><Q><G><D><D><P><K><T><D><F><R><G><M><G><I><L><G><L><I><N><L><V><Y><F><S><E><N><Y><T><S><E><A><H><Q><I><L><S><R><S><N><H><P><K><L><G><Y><S><Y><A><I><V><G><I><N><L><T><E><M><A><Y><S><L><L><K><S><E><A><L><K><F><H><L><Y><N><L><V><P><G><I><P><T><M><E><H><F><H><Q><F><Y><C><Y><L><V><Y><E><F><D><K><F><W><F><E><E><E><P><E><S><I><M><Y><F><N><L><Y><R><E><K><F><H><E><K><I><K><G><L><L><L><D><C><N><V><A><L><T><L><K><V>
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.<BOP>
Q8IZ81
Q9BT49
THAP7_HUMAN
THAP domain-containing protein 7
Homo
<M><P><R><H><C><S><A><A><G><C><C><T><R><D><T><R><E><T><R><N><R><G><I><S><F><H><R><L><P><K><K><D><N><P><R><R><G><L><W><L><A><N><C><Q><R><L><D><P><S><G><Q><G><L><W><D><P><A><S><E><Y><I><Y><F><C><S><K><H><F><E><E><D><C><F><E><L><V><G><I><S><G><Y><H><R><L><K><E><G><A><V><P><T><I><F><E><S><F><S><K><L><R><R><T><T><K><T><K><G><H><S><Y><P><P><G><P><A><E><V><S><R><L><R><R><C><R><K><R><C><S><E><G><R><G><P><T><T><P><F><S><P><P><P><P><A><D><V><T><C><F><P><V><E><E><A><S><A><P><A><T><L><P><A><S><P><A><G><R><L><E><P><G><L><S><S><P><F><S><D><L><L><G><P><L><G><A><Q><A><D><E><A><G><C><S><A><Q><P><S><P><E><R><Q><P><S><P><L><E><P><R><P><V><S><P><S><A><Y><M><L><R><L><P><P><P><A><G><A><Y><I><Q><N><E><H><S><Y><Q><V><G><S><A><L><L><W><K><R><R><A><E><A><A><L><D><A><L><D><K><A><Q><R><Q><L><Q><A><C><K><R><R><E><Q><R><L><R><L><R><L><T><K><L><Q><Q><E><R><A><R><E><K><R><A><Q><A><D><A><R><Q><T><L><K><E><H><V><Q><D><F><A><M><Q><L><S><S><S><M><A>
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.<BOP>
Q9BT49
Q96P56
CTSR2_HUMAN
Cation channel sperm-associated protein 2
Homo
<M><A><A><Y><Q><Q><E><E><Q><M><Q><L><P><R><A><D><A><I><R><S><R><L><I><D><T><F><S><L><I><E><H><L><Q><G><L><S><Q><A><V><P><R><H><T><I><R><E><L><L><D><P><S><R><Q><K><K><L><V><L><G><D><Q><H><Q><L><V><R><F><S><I><K><P><Q><R><I><E><Q><I><S><H><A><Q><R><L><L><S><R><L><H><V><R><C><S><Q><R><P><P><L><S><L><W><A><G><W><V><L><E><C><P><L><F><K><N><F><I><I><F><L><V><F><L><N><T><I><I><L><M><V><E><I><E><L><L><E><S><T><N><T><K><L><W><P><L><K><L><T><L><E><V><A><A><W><F><I><L><L><I><F><I><L><E><I><L><L><K><W><L><S><N><F><S><V><F><W><K><S><A><W><N><V><F><D><F><V><V><T><M><L><S><L><L><P><E><V><V><V><L><V><G><V><T><G><Q><S><V><W><L><Q><L><L><R><I><C><R><V><L><R><S><L><K><L><L><A><Q><F><R><Q><I><Q><I><I><I><L><V><L><V><R><A><L><K><S><M><T><F><L><L><M><L><L><L><I><F><F><Y><I><F><A><V><T><G><V><Y><V><F><S><E><Y><T><R><S><P><R><Q><D><L><E><Y><H><V><F><F><S><D><L><P><N><S><L><V><T><V><F><I><L><F><T><L><D><H><W><Y><A><L><L><Q><D><V><W><K><V><P><E><V><S><R><I><F><S><S><I><Y><F><I><L><W><L><L><L><G><S><I><I><F><R><S><I><I><V><A><M><M><V><T><N><F><Q><N><I><R><K><E><L><N><E><E><M><A><R><R><E><V><Q><L><K><A><D><M><F><K><R><Q><I><I><Q><R><R><K><N><M><S><H><E><A><L><T><S><S><H><S><K><I><E><D><S><S><R><G><A><S><Q><Q><R><E><S><L><D><L><S><E><V><S><E><V><E><S><N><Y><G><A><T><E><E><D><L><I><T><S><A><S><K><T><E><E><T><L><S><K><K><R><E><Y><Q><S><S><S><C><V><S><S><T><S><S><S><Y><S><S><S><S><E><S><R><F><S><E><S><I><G><R><L><D><W><E><T><L><V><H><E><N><L><P><G><L><M><E><M><D><Q><D><D><R><V><W><P><R><D><S><L><F><R><Y><F><E><L><L><E><K><L><Q><Y><N><L><E><E><R><K><K><L><Q><E><F><A><V><Q><A><L><M><N><L><E><D><K>
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.<BOP>
Q96P56
Q8TD46
MO2R1_HUMAN
Cell surface glycoprotein OX2 receptor 1
Homo
<M><L><C><P><W><R><T><A><N><L><G><L><L><L><I><L><T><I><F><L><V><A><A><S><S><S><L><C><M><D><E><K><Q><I><T><Q><N><Y><S><K><V><L><A><E><V><N><T><S><W><P><V><K><M><A><T><N><A><V><L><C><C><P><P><I><A><L><R><N><L><I><I><I><T><W><E><I><I><L><R><G><Q><P><S><C><T><K><A><Y><K><K><E><T><N><E><T><K><E><T><N><C><T><D><E><R><I><T><W><V><S><R><P><D><Q><N><S><D><L><Q><I><R><T><V><A><I><T><H><D><G><Y><Y><R><C><I><M><V><T><P><D><G><N><F><H><R><G><Y><H><L><Q><V><L><V><T><P><E><V><T><L><F><Q><N><R><N><R><T><A><V><C><K><A><V><A><G><K><P><A><A><H><I><S><W><I><P><E><G><D><C><A><T><K><Q><E><Y><W><S><N><G><T><V><T><V><K><S><T><C><H><W><E><V><H><N><V><S><T><V><T><C><H><V><S><H><L><T><G><N><K><S><L><Y><I><E><L><L><P><V><P><G><A><K><K><S><A><K><L><Y><I><P><Y><I><I><L><T><I><I><I><L><T><I><V><G><F><I><W><L><L><K><V><N><G><C><R><K><Y><K><L><N><K><T><E><S><T><P><V><V><E><E><D><E><M><Q><P><Y><A><S><Y><T><E><K><N><N><P><L><Y><D><T><T><N><K><V><K><A><S><E><A><L><Q><S><E><V><D><T><D><L><H><T><L>
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.<BOP>
Q8TD46
P31314
TLX1_HUMAN
T-cell leukemia/lymphoma protein 3
Homo
<M><E><H><L><G><P><H><H><L><H><P><G><H><A><E><P><I><S><F><G><I><D><Q><I><L><N><S><P><D><Q><G><G><C><M><G><P><A><S><R><L><Q><D><G><E><Y><G><L><G><C><L><V><G><G><A><Y><T><Y><G><G><G><G><S><A><A><A><T><G><A><G><G><A><G><A><Y><G><T><G><G><P><G><G><P><G><G><P><A><G><G><G><G><A><C><S><M><G><P><L><T><G><S><Y><N><V><N><M><A><L><A><G><G><P><G><P><G><G><G><G><G><S><S><G><G><A><G><A><L><S><A><A><G><V><I><R><V><P><A><H><R><P><L><A><G><A><V><A><H><P><Q><P><L><A><T><G><L><P><T><V><P><S><V><P><A><M><P><G><V><N><N><L><T><G><L><T><F><P><W><M><E><S><N><R><R><Y><T><K><D><R><F><T><G><H><P><Y><Q><N><R><T><P><P><K><K><K><K><P><R><T><S><F><T><R><L><Q><I><C><E><L><E><K><R><F><H><R><Q><K><Y><L><A><S><A><E><R><A><A><L><A><K><A><L><K><M><T><D><A><Q><V><K><T><W><F><Q><N><R><R><T><K><W><R><R><Q><T><A><E><E><R><E><A><E><R><Q><Q><A><N><R><I><L><L><Q><L><Q><Q><E><A><F><Q><K><S><L><A><Q><P><L><P><A><D><P><L><C><V><H><N><S><S><L><F><A><L><Q><N><L><Q><P><W><S><D><D><S><T><K><I><T><S><V><T><S><V><A><S><A><C><E>
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.<BOP>
P31314
Q9NTI7
INKA2_HUMAN
Inka box actin regulator 2
Homo
<M><T><M><E><S><R><E><M><D><C><Y><L><R><R><L><K><Q><E><L><M><S><M><K><E><V><G><D><G><L><Q><D><Q><M><N><C><M><M><G><A><L><Q><E><L><K><L><L><Q><V><Q><T><A><L><E><Q><L><E><I><S><G><G><G><P><V><P><G><S><P><E><G><P><R><T><Q><C><E><H><P><C><W><E><G><G><R><G><P><A><R><P><T><V><C><S><P><S><S><Q><P><S><L><G><S><S><T><K><F><P><S><H><R><S><V><C><G><R><D><L><A><P><L><P><R><T><Q><P><H><Q><S><C><A><Q><Q><G><P><E><R><V><E><P><D><D><W><T><S><T><L><M><S><R><G><R><N><R><Q><P><L><V><L><G><D><N><V><F><A><D><L><V><G><N><W><L><D><L><P><E><L><E><K><G><G><E><K><G><E><T><G><G><A><R><E><P><K><G><E><K><G><Q><P><Q><E><L><G><R><R><F><A><L><T><A><N><I><F><K><K><F><L><R><S><V><R><P><D><R><D><R><L><L><K><E><K><P><G><W><V><T><P><M><V><P><E><S><R><T><G><R><S><Q><K><V><K><K><R><S><L><S><K><G><S><G><H><F><P><F><P><G><T><G><E><H><R><R><G><E><N><P><P><T><S><C><P><K><A><L><E><H><S><P><S><G><F><D><I><N><T><A><V><W><V>
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.<BOP>
Q9NTI7
Q8N127
O5AS1_HUMAN
Olfactory receptor OR11-168
Homo
<M><L><E><S><N><Y><T><M><P><T><E><F><L><F><V><G><F><T><D><Y><L><P><L><R><V><T><L><F><L><V><F><L><L><V><Y><T><L><T><M><V><G><N><I><L><L><I><I><L><V><N><I><N><S><S><L><Q><I><P><M><Y><Y><F><L><S><N><L><S><F><L><D><I><S><C><S><T><A><I><T><P><K><M><L><A><N><F><L><A><S><R><K><S><I><S><P><Y><G><C><A><L><Q><M><F><F><F><A><S><F><A><D><A><E><C><L><I><L><A><A><M><A><Y><D><R><Y><A><A><I><C><N><P><L><L><Y><T><T><L><M><S><R><R><V><C><V><C><F><I><V><L><A><Y><F><S><G><S><T><T><S><L><V><H><V><C><L><T><F><R><L><S><F><C><G><S><N><I><V><N><H><F><F><C><D><I><P><P><L><L><A><L><S><C><T><D><T><Q><I><N><Q><L><L><L><F><A><L><C><S><F><I><Q><T><S><T><F><V><V><I><F><I><S><Y><F><C><I><L><I><T><V><L><S><I><K><S><S><G><G><R><S><K><T><F><S><T><C><A><S><H><L><I><A><V><T><L><F><Y><G><A><L><L><F><M><Y><L><Q><P><T><T><S><Y><S><L><D><T><D><K><V><V><A><V><F><Y><T><V><V><F><P><M><F><N><P><I><I><Y><S><F><R><N><K><D><V><K><N><A><L><K><K><L><L><E><R><I><G><Y><S><N><E><W><Y><L><N><R><L><R><I><V><N><I>
Odorant receptor.<BOP>
Q8N127
Q9BQ66
KR412_HUMAN
Ultrahigh sulfur keratin-associated protein 4.12
Homo
<M><V><N><S><C><C><G><S><V><C><S><D><Q><G><C><G><L><E><N><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><Q><T><T><C><C><R><T><T><C><C><R><P><S><C><C><V><S><S><C><C><R><P><Q><C><C><Q><S><V><C><C><Q><P><T><C><C><R><P><S><C><C><I><S><S><S><C><C><P><S><C><C><E><S><S><C><C><R><P><C><C><C><L><R><P><V><C><G><R><V><S><C><H><T><T><C><Y><R><P><T><C><V><I><S><T><C><P><R><P><L><C><C><A><S><S><C><C>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q9BQ66
A0A087WSY6
KVD15_HUMAN
Immunoglobulin kappa variable 3D-15
Homo
<M><E><A><P><A><Q><L><L><F><L><L><L><L><W><L><P><D><T><T><G><E><I><V><M><T><Q><S><P><A><T><L><S><V><S><P><G><E><R><A><T><L><S><C><R><A><S><Q><S><V><S><S><N><L><A><W><Y><Q><Q><K><P><G><Q><A><P><R><L><L><I><Y><G><A><S><I><R><A><T><G><I><P><A><R><F><S><G><S><G><S><G><T><E><F><T><L><T><I><S><I><L><Q><S><E><D><F><A><V><Y><Y><C><Q><Q><Y><N><N><W><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A087WSY6
Q96NL3
ZN599_HUMAN
Zinc finger protein 599
Homo
<M><A><A><P><A><L><A><L><V><S><F><E><D><V><V><V><T><F><T><G><E><E><W><G><H><L><D><L><A><Q><R><T><L><Y><Q><E><V><M><L><E><T><C><R><L><L><V><S><L><G><H><P><V><P><K><P><E><L><I><Y><L><L><E><H><G><Q><E><L><W><T><V><K><R><G><L><S><Q><S><T><C><A><G><E><K><A><K><P><K><I><T><E><P><T><A><S><Q><L><A><F><S><E><E><S><S><F><Q><E><L><L><A><Q><R><S><S><R><D><S><R><L><G><Q><A><R><D><E><E><K><L><I><K><I><Q><E><G><N><L><R><P><G><T><N><P><H><K><E><I><C><P><E><K><L><S><Y><K><H><D><D><L><E><P><D><D><S><L><G><L><R><V><L><Q><E><R><V><T><P><Q><D><A><L><H><E><C><D><S><Q><G><P><G><K><D><P><M><T><D><A><R><N><N><P><Y><T><C><T><E><C><G><K><G><F><S><K><K><W><A><L><V><R><H><Q><Q><I><H><A><G><V><K><P><Y><E><C><N><E><C><G><K><A><C><R><Y><M><A><D><V><I><R><H><M><R><L><H><T><G><E><K><P><Y><K><C><I><E><C><G><K><A><F><K><R><R><F><H><L><T><E><H><Q><R><I><H><T><G><D><K><P><Y><E><C><K><E><C><G><K><A><F><T><H><R><S><S><F><I><Q><H><N><M><T><H><T><R><E><K><P><F><L><C><K><E><C><G><K><A><F><Y><Y><S><S><S><F><A><Q><H><M><R><I><H><T><G><K><K><L><Y><E><C><G><E><C><G><K><A><F><T><H><R><S><T><F><I><Q><H><N><V><T><H><T><G><E><K><P><F><L><C><K><E><C><G><K><T><F><C><L><N><S><S><F><T><Q><H><M><R><I><H><T><G><E><K><P><Y><E><C><G><E><C><G><K><A><F><T><H><R><S><T><F><I><R><H><K><R><T><H><T><G><E><K><P><F><E><C><K><E><C><G><K><A><F><C><D><S><S><S><L><I><Q><H><M><R><I><H><T><G><E><K><P><Y><E><C><S><E><C><G><K><A><F><T><H><H><S><V><F><I><R><H><N><R><T><H><S><G><Q><K><P><L><E><C><K><E><C><A><K><A><F><Y><Y><S><S><S><F><T><R><H><M><R><I><H><T><G><E><K><P><Y><V><C><R><E><C><G><K><A><F><T><Q><P><A><N><F><V><R><H><N><R><I><H><T><G><E><K><P><F><E><C><K><E><C><E><K><A><F><C><D><N><F><A><L><T><Q><H><M><R><T><H><T><G><E><K><P><F><E><C><N><E><C><G><K><T><F><S><H><S><S><S><F><T><H><H><R><K><I><H><T><R><V>
May be involved in transcriptional regulation.<BOP>
Q96NL3
Q16763
UBE2S_HUMAN
Ubiquitin-protein ligase S
Homo
<M><N><S><N><V><E><N><L><P><P><H><I><I><R><L><V><Y><K><E><V><T><T><L><T><A><D><P><P><D><G><I><K><V><F><P><N><E><E><D><L><T><D><L><Q><V><T><I><E><G><P><E><G><T><P><Y><A><G><G><L><F><R><M><K><L><L><L><G><K><D><F><P><A><S><P><P><K><G><Y><F><L><T><K><I><F><H><P><N><V><G><A><N><G><E><I><C><V><N><V><L><K><R><D><W><T><A><E><L><G><I><R><H><V><L><L><T><I><K><C><L><L><I><H><P><N><P><E><S><A><L><N><E><E><A><G><R><L><L><L><E><N><Y><E><E><Y><A><A><R><A><R><L><L><T><E><I><H><G><G><A><G><G><P><S><G><R><A><E><A><G><R><A><L><A><S><G><T><E><A><S><S><T><D><P><G><A><P><G><G><P><G><G><A><E><G><P><M><A><K><K><H><A><G><E><R><D><K><K><L><A><A><K><K><K><T><D><K><K><R><A><L><R><R><L>
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit . Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A . In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination .<BOP>
Q16763
Q9BXJ5
C1QT2_HUMAN
Complement C1q tumor necrosis factor-related protein 2
Homo
<M><I><P><W><V><L><L><A><C><A><L><P><C><A><A><D><P><L><L><G><A><F><A><R><R><D><F><R><K><G><S><P><Q><L><V><C><S><L><P><G><P><Q><G><P><P><G><P><P><G><A><P><G><P><S><G><M><M><G><R><M><G><F><P><G><K><D><G><Q><D><G><H><D><G><D><R><G><D><S><G><E><E><G><P><P><G><R><T><G><N><R><G><K><P><G><P><K><G><K><A><G><A><I><G><R><A><G><P><R><G><P><K><G><V><N><G><T><P><G><K><H><G><T><P><G><K><K><G><P><K><G><K><K><G><E><P><G><L><P><G><P><C><S><C><G><S><G><H><T><K><S><A><F><S><V><A><V><T><K><S><Y><P><R><E><R><L><P><I><K><F><D><K><I><L><M><N><E><G><G><H><Y><N><A><S><S><G><K><F><V><C><G><V><P><G><I><Y><Y><F><T><Y><D><I><T><L><A><N><K><H><L><A><I><G><L><V><H><N><G><Q><Y><R><I><R><T><F><D><A><N><T><G><N><H><D><V><A><S><G><S><T><I><L><A><L><K><Q><G><D><E><V><W><L><Q><I><F><Y><S><E><Q><N><G><L><F><Y><D><P><Y><W><T><D><S><L><F><T><G><F><L><I><Y><A><D><Q><D><D><P><N><E><V>
Involved in the regulation of lipid metabolism in adipose tissue and liver.<BOP>
Q9BXJ5
Q6NT32
EST5A_HUMAN
Carboxylesterase-like urinary excreted protein homolog
Homo
<M><S><G><N><W><V><H><P><G><Q><I><L><I><W><A><I><W><V><L><A><A><P><T><K><G><P><S><A><E><G><P><Q><R><N><T><R><L><G><W><I><Q><G><K><Q><V><T><V><L><G><S><P><V><P><V><N><V><F><L><G><V><P><F><A><A><P><P><L><G><S><L><R><F><T><N><P><Q><P><A><S><P><W><D><N><L><R><E><A><T><S><Y><P><N><L><C><L><Q><N><S><E><W><L><L><L><D><Q><H><M><L><K><V><H><Y><P><K><F><G><V><S><E><D><C><L><Y><L><N><I><Y><A><P><A><H><A><D><T><G><S><K><L><P><V><L><V><W><F><P><G><G><A><F><K><T><G><S><A><S><I><F><D><G><S><A><L><A><A><Y><E><D><V><L><V><V><V><V><Q><Y><R><L><G><I><F><G><F><F><T><T><W><D><Q><H><A><P><G><N><W><A><F><K><D><Q><V><A><A><L><S><W><V><Q><K><N><I><E><F><F><G><G><D><P><S><S><V><T><I><F><G><E><S><A><G><A><I><S><V><S><S><L><I><L><S><P><M><A><K><G><L><F><H><K><A><I><M><E><S><G><V><A><I><I><P><Y><L><E><A><H><D><Y><E><K><S><E><D><L><Q><V><V><A><H><F><C><G><N><N><A><S><D><S><E><A><L><L><R><C><L><R><T><K><P><S><K><E><L><L><T><L><S><Q><K><T><K><S><F><T><R><V><V><D><G><A><F><F><P><N><E><P><L><D><L><L><S><Q><K><A><F><K><A><I><P><S><I><I><G><V><N><N><H><E><C><G><F><L><L><P><M><K><E><A><P><E><I><L><S><G><S><N><K><S><L><A><L><H><L><I><Q><N><I><L><H><I><P><P><Q><Y><L><H><L><V><A><N><E><Y><F><H><D><K><H><S><L><T><E><I><R><D><S><L><L><D><L><L><G><D><V><F><F><V><V><P><A><L><I><T><A><R><Y><H><R><D><A><G><A><P><V><Y><F><Y><E><F><R><H><R><P><Q><C><F><E><D><T><K><P><A><F><V><K><A><D><H><A><D><E><V><R><F><V><F><G><G><A><F><L><K><G><D><I><V><M><F><E><G><A><T><E><E><E><K><L><L><S><R><K><M><M><K><Y><W><A><T><F><A><R><T><G><N><P><N><G><N><D><L><S><L><W><P><A><Y><N><L><T><E><Q><Y><L><Q><L><D><L><N><M><S><L><G><Q><R><L><K><E><P><R><V><D><F><W><T><S><T><I><P><L><I><L><S><A><S><D><M><L><H><S><P><L><S><S><L><T><F><L><S><L><L><Q><P><F><F><F><F><C><A><P>
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.<BOP>
Q6NT32
Q9UJG1
MSPD1_HUMAN
Motile sperm domain-containing protein 1
Homo
<M><H><Q><Q><K><R><Q><P><E><L><V><E><G><N><L><P><V><F><V><F><P><T><E><L><I><F><Y><A><D><D><Q><S><T><H><K><Q><V><L><T><L><Y><N><P><Y><E><F><A><L><K><F><K><V><L><C><T><T><P><N><K><Y><V><V><V><D><A><A><G><A><V><K><P><Q><C><C><V><D><I><V><I><R><H><R><D><V><R><S><C><H><Y><G><V><I><D><K><F><R><L><Q><V><S><E><Q><S><Q><R><K><A><L><G><R><K><E><V><V><A><T><L><L><P><S><A><K><E><Q><Q><K><E><E><E><E><K><R><L><K><E><H><L><T><E><S><L><F><F><E><Q><S><F><Q><P><E><N><R><A><V><S><S><G><P><S><L><L><T><V><F><L><G><V><V><C><I><A><A><L><M><L><P><T><L><G><D><V><E><S><L><V><P><L><Y><L><H><L><S><V><N><Q><K><L><V><A><A><Y><I><L><G><L><I><T><M><A><I><L><R><T>
Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.<BOP>
Q9UJG1
Q6L8H2
KRA53_HUMAN
Ultrahigh sulfur keratin-associated protein 5.3
Homo
<M><G><C><S><G><C><S><G><G><C><G><S><S><C><G><G><C><G><S><S><C><G><G><C><G><S><G><Y><G><G><C><G><S><G><C><C><V><P><V><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><V><C><G><S><C><G><G><C><K><G><G><C><G><S><C><G><G><S><K><G><G><C><G><S><S><C><C><V><P><V><C><C><S><S><S><C><G><S><C><G><G><S><K><G><V><C><G><F><R><G><G><S><K><G><G><C><G><S><C><G><C><S><Q><C><S><C><Y><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><S><C><S><Q><S><S><C><C><K><P><C><C><S><Q><S><S><C><C><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><C><S><Q><S><S><C><C><K><P><C><C><C><S><S><G><C><G><S><S><C><C><Q><S><S><C><C><K><P><C><S><S><Q><S><S><C><C><V><P><I><C><C><Q><C><K><I>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q6L8H2
Q6P1Q9
MET2B_HUMAN
Methyltransferase-like protein 2B
Homo
<M><A><G><S><Y><P><E><G><A><P><A><I><L><A><D><K><R><Q><Q><F><G><S><R><F><L><S><D><P><A><R><V><F><H><H><N><A><W><D><N><V><E><W><S><E><E><Q><A><A><A><A><E><R><K><V><Q><E><N><S><I><Q><R><V><C><Q><E><K><Q><V><D><Y><E><I><N><A><H><K><Y><W><N><D><F><Y><K><I><H><E><N><G><F><F><K><D><R><H><W><L><F><T><E><F><P><E><L><A><P><S><Q><N><Q><N><H><L><K><D><W><F><L><E><N><K><S><E><V><C><E><C><R><N><N><E><D><G><P><G><L><I><M><E><E><Q><H><K><C><S><S><K><S><L><E><H><K><T><Q><T><P><P><V><E><E><N><V><T><Q><K><I><S><D><L><E><I><C><A><D><E><F><P><G><S><S><A><T><Y><R><I><L><E><V><G><C><G><V><G><N><T><V><F><P><I><L><Q><T><N><N><D><P><G><L><F><V><Y><C><C><D><F><S><S><T><A><I><E><L><V><Q><T><N><S><E><Y><D><P><S><R><C><F><A><F><V><H><D><L><C><D><E><E><K><S><Y><P><V><P><K><G><S><L><D><I><I><I><L><I><F><V><L><S><A><V><V><P><D><K><M><Q><K><A><I><N><R><L><S><R><L><L><K><P><G><G><M><V><L><L><R><D><Y><G><R><Y><D><M><A><Q><L><R><F><K><K><G><Q><C><L><S><G><N><F><Y><V><R><G><D><G><T><R><V><Y><F><F><T><Q><E><E><L><D><T><L><F><T><T><A><G><L><E><K><V><Q><N><L><V><D><R><R><L><Q><V><N><R><G><K><Q><L><T><M><Y><R><V><W><I><Q><C><K><Y><C><K><P><L><L><S><S><T><S>
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).<BOP>
Q6P1Q9
P23083
HV102_HUMAN
Ig heavy chain V-I region V35
Homo
<M><D><W><T><W><R><I><L><F><L><V><A><A><A><T><G><A><H><S><Q><V><Q><L><V><Q><S><G><A><E><V><K><K><P><G><A><S><V><K><V><S><C><K><A><S><G><Y><T><F><T><G><Y><Y><M><H><W><V><R><Q><A><P><G><Q><G><L><E><W><M><G><W><I><N><P><N><S><G><G><T><N><Y><A><Q><K><F><Q><G><W><V><T><M><T><R><D><T><S><I><S><T><A><Y><M><E><L><S><R><L><R><S><D><D><T><A><V><Y><Y><C><A><R>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P23083
Q8WWZ1
IL1FA_HUMAN
Interleukin-38
Homo
<M><C><S><L><P><M><A><R><Y><Y><I><I><K><Y><A><D><Q><K><A><L><Y><T><R><D><G><Q><L><L><V><G><D><P><V><A><D><N><C><C><A><E><K><I><C><I><L><P><N><R><G><L><A><R><T><K><V><P><I><F><L><G><I><Q><G><G><S><R><C><L><A><C><V><E><T><E><E><G><P><S><L><Q><L><E><D><V><N><I><E><E><L><Y><K><G><G><E><E><A><T><R><F><T><F><F><Q><S><S><S><G><S><A><F><R><L><E><A><A><A><W><P><G><W><F><L><C><G><P><A><E><P><Q><Q><P><V><Q><L><T><K><E><S><E><P><S><A><R><T><K><F><Y><F><E><Q><S><W>
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.<BOP>
Q8WWZ1
Q9NQZ3
DAZ1_HUMAN
Deleted in azoospermia protein 1
Homo
<M><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K><L><K><L><G><P><A><I><R><K><Q><K><L><C><A><R><H><V><Q><P><R><P><L><V><V><N><P><P><P><P><P><Q><F><Q><N><V><W><R><N><P><N><T><E><T><Y><L><Q><P><Q><I><T><P><N><P><V><T><Q><H><V><Q><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K><L><K><L><G><P><A><I><R><K><Q><K><L><C><A><R><H><V><Q><P><R><P><L><V><V><N><P><P><P><P><P><Q><F><Q><N><V><W><R><N><P><N><T><E><T><Y><L><Q><P><Q><I><T><P><N><P><V><T><Q><H><V><Q><S><A><A><N><P><E><T><P><N><S><T><I><S><R><E><A><S><T><Q><S><S><S><A><A><A><S><Q><G><W><V><L><P><E><G><K><I><V><P><N><T><V><F><V><G><G><I><D><A><R><M><D><E><T><E><I><G><S><C><F><G><R><Y><G><S><V><K><E><V><K><I><I><T><N><R><T><G><V><S><K><G><Y><G><F><V><S><F><V><N><D><V><D><V><Q><K><I><V><G><S><Q><I><H><F><H><G><K><K><L><K><L><G><P><A><I><R><K><Q><K><L><C><A><R><H><V><Q><P><R><P><L><V><V><N><P><P><P><P><P><Q><F><Q><N><V><W><R><N><P><N><T><E><T><Y><L><Q><P><Q><I><T><P><N><P><V><T><Q><H><V><Q><A><Y><S><A><Y><P><H><S><P><G><Q><V><I><T><G><C><Q><L><L><V><Y><N><Y><Q><E><Y><P><T><Y><P><D><S><A><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><P><F><P><A><Y><P><R><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><P><F><P><A><Y><P><S><S><P><F><Q><V><T><A><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><F><Q><V><A><T><G><Y><Q><F><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><P><V><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><S><S><P><F><Q><V><T><T><G><Y><Q><L><P><V><Y><N><Y><Q><A><F><P><A><Y><P><N><S><A><V><Q><V><T><T><G><Y><Q><F><H><V><Y><N><Y><Q><M><P><P><Q><C><P><V><G><E><Q><R><R><N><L><W><T><E><A><Y><K><W><W><Y><L><V><C><L><I><Q><R><R><D>
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.<BOP>
Q9NQZ3
P28072
PSB6_HUMAN
Proteasome subunit Y
Homo
<M><A><A><T><L><L><A><A><R><G><A><G><P><A><P><A><W><G><P><E><A><F><T><P><D><W><E><S><R><E><V><S><T><G><T><T><I><M><A><V><Q><F><D><G><G><V><V><L><G><A><D><S><R><T><T><T><G><S><Y><I><A><N><R><V><T><D><K><L><T><P><I><H><D><R><I><F><C><C><R><S><G><S><A><A><D><T><Q><A><V><A><D><A><V><T><Y><Q><L><G><F><H><S><I><E><L><N><E><P><P><L><V><H><T><A><A><S><L><F><K><E><M><C><Y><R><Y><R><E><D><L><M><A><G><I><I><I><A><G><W><D><P><Q><E><G><G><Q><V><Y><S><V><P><M><G><G><M><M><V><R><Q><S><F><A><I><G><G><S><G><S><S><Y><I><Y><G><Y><V><D><A><T><Y><R><E><G><M><T><K><E><E><C><L><Q><F><T><A><N><A><L><A><L><A><M><E><R><D><G><S><S><G><G><V><I><R><L><A><A><I><A><E><S><G><V><E><R><Q><V><L><L><G><D><Q><I><P><K><F><A><V><A><T><L><P><P><A>
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.<BOP>
P28072
Q96A58
RERG_HUMAN
Ras-related and estrogen-regulated growth inhibitor
Homo
<M><A><K><S><A><E><V><K><L><A><I><F><G><R><A><G><V><G><K><S><A><L><V><V><R><F><L><T><K><R><F><I><W><E><Y><D><P><T><L><E><S><T><Y><R><H><Q><A><T><I><D><D><E><V><V><S><M><E><I><L><D><T><A><G><Q><E><D><T><I><Q><R><E><G><H><M><R><W><G><E><G><F><V><L><V><Y><D><I><T><D><R><G><S><F><E><E><V><L><P><L><K><N><I><L><D><E><I><K><K><P><K><N><V><T><L><I><L><V><G><N><K><A><D><L><D><H><S><R><Q><V><S><T><E><E><G><E><K><L><A><T><E><L><A><C><A><F><Y><E><C><S><A><C><T><G><E><G><N><I><T><E><I><F><Y><E><L><C><R><E><V><R><R><R><R><M><V><Q><G><K><T><R><R><R><S><S><T><T><H><V><K><Q><A><I><N><K><M><L><T><K><I><S><S>
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.<BOP>
Q96A58
Q86WT6
TRI69_HUMAN
Tripartite motif-containing protein 69
Homo
<M><E><V><S><T><N><P><S><S><N><I><D><P><G><D><Y><V><E><M><N><D><S><I><T><H><L><P><S><K><V><V><I><Q><D><I><T><M><E><L><H><C><P><L><C><N><D><W><F><R><D><P><L><M><L><S><C><G><H><N><F><C><E><A><C><I><Q><D><F><W><R><L><Q><A><K><E><T><F><C><P><E><C><K><M><L><C><Q><Y><N><N><C><T><F><N><P><V><L><D><K><L><V><E><K><I><K><K><L><P><L><L><K><G><H><P><Q><C><P><E><H><G><E><N><L><K><L><F><S><K><P><D><G><K><L><I><C><F><Q><C><K><D><A><R><L><S><V><G><Q><S><K><E><F><L><Q><I><S><D><A><V><H><F><F><T><E><E><L><A><I><Q><Q><G><Q><L><E><T><T><L><K><E><L><Q><T><L><R><N><M><Q><K><E><A><I><A><A><H><K><E><N><K><L><H><L><Q><Q><H><V><S><M><E><F><L><K><L><H><Q><F><L><H><S><K><E><K><D><I><L><T><E><L><R><E><E><G><K><A><L><N><E><E><M><E><L><N><L><S><Q><L><Q><E><Q><C><L><L><A><K><D><M><L><V><S><I><Q><A><K><T><E><Q><Q><N><S><F><D><F><L><K><D><I><T><T><L><L><H><S><L><E><Q><G><M><K><V><L><A><T><R><E><L><I><S><R><K><L><N><L><G><Q><Y><K><G><P><I><Q><Y><M><V><W><R><E><M><Q><D><T><L><C><P><G><L><S><P><L><T><L><D><P><K><T><A><H><P><N><L><V><L><S><K><S><Q><T><S><V><W><H><G><D><I><K><K><I><M><P><D><D><P><E><R><F><D><S><S><V><A><V><L><G><S><R><G><F><T><S><G><K><W><Y><W><E><V><E><V><A><K><K><T><K><W><T><V><G><V><V><R><E><S><I><I><R><K><G><S><C><P><L><T><P><E><Q><G><F><W><L><L><R><L><R><N><Q><T><D><L><K><A><L><D><L><P><S><F><S><L><T><L><T><N><N><L><D><K><V><G><I><Y><L><D><Y><E><G><G><Q><L><S><F><Y><N><A><K><T><M><T><H><I><Y><T><F><S><N><T><F><M><E><K><L><Y><P><Y><F><C><P><C><L><N><D><G><G><E><N><K><E><P><L><H><I><L><H><P><Q>
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.<BOP>
Q86WT6
W5XKT8
SACA6_HUMAN
BACHELOR-like protein
Homo
<M><A><L><L><A><L><A><S><A><V><P><S><A><L><L><A><L><A><V><F><R><V><P><A><W><A><C><L><L><C><F><T><T><Y><S><E><R><L><R><I><C><Q><M><F><V><G><M><R><S><P><K><L><E><E><C><E><E><A><F><T><A><A><F><Q><G><L><S><D><T><E><I><N><Y><D><E><R><S><H><L><H><D><T><F><T><Q><M><T><H><A><L><Q><E><L><A><A><A><Q><G><S><F><E><V><A><F><P><D><A><A><E><K><M><K><K><V><I><T><Q><L><K><E><A><Q><A><C><I><P><P><C><G><L><Q><E><F><A><R><R><F><L><C><S><G><C><Y><S><R><V><C><D><L><P><L><D><C><P><V><Q><D><V><T><V><T><R><G><D><Q><A><M><F><S><C><I><V><N><F><Q><L><P><K><E><E><I><T><Y><S><W><K><F><A><G><G><G><L><R><T><Q><D><L><S><Y><F><R><D><M><P><R><A><E><G><Y><L><A><R><I><R><P><A><Q><L><T><H><R><G><T><F><S><C><V><I><K><Q><D><Q><R><P><L><A><R><L><Y><F><F><L><N><V><T><G><P><P><P><R><A><E><T><E><L><Q><A><S><F><R><E><V><L><R><W><A><P><R><D><A><E><L><I><E><P><W><R><P><S><L><G><E><L><L><A><R><P><E><A><L><T><P><S><N><L><F><L><L><A><V><L><G><A><L><A><S><A><S><A><T><V><L><A><W><M><F><F><R><W><Y><C><S><G><N>
Sperm protein required for fusion of sperm with the egg membrane during fertilization.<BOP>
W5XKT8
Q6ZMR5
TM11A_HUMAN
Esophageal cancer-susceptibility gene 1 protein
Homo
<M><M><Y><R><T><V><G><F><G><T><R><S><R><N><L><K><P><W><M><I><A><V><L><I><V><L><S><L><T><V><V><A><V><T><I><G><L><L><V><H><F><L><V><F><D><Q><K><K><E><Y><Y><H><G><S><F><K><I><L><D><P><Q><I><N><N><N><F><G><Q><S><N><T><Y><Q><L><K><D><L><R><E><T><T><E><N><L><V><D><E><I><F><I><D><S><A><W><K><K><N><Y><I><K><N><Q><V><V><R><L><T><P><E><E><D><G><V><K><V><D><V><I><M><V><F><Q><F><P><S><T><E><Q><R><A><V><R><E><K><K><I><Q><S><I><L><N><Q><K><I><R><N><L><R><A><L><P><I><N><A><S><S><V><Q><V><N><A><M><S><S><S><T><G><E><L><T><V><Q><A><S><C><G><K><R><V><V><P><L><N><V><N><R><I><A><S><G><V><I><A><P><K><A><A><W><P><W><Q><A><S><L><Q><Y><D><N><I><H><Q><C><G><A><T><L><I><S><N><T><W><L><V><T><A><A><H><C><F><Q><K><Y><K><N><P><H><Q><W><T><V><S><F><G><T><K><I><N><P><P><L><M><K><R><N><V><R><R><F><I><I><H><E><K><Y><R><S><A><A><R><E><Y><D><I><A><V><V><Q><V><S><S><R><V><T><F><S><D><D><I><R><R><I><C><L><P><E><A><S><A><S><F><Q><P><N><L><T><V><H><I><T><G><F><G><A><L><Y><Y><G><G><E><S><Q><N><D><L><R><E><A><R><V><K><I><I><S><D><D><V><C><K><Q><P><Q><V><Y><G><N><D><I><K><P><G><M><F><C><A><G><Y><M><E><G><I><Y><D><A><C><R><G><D><S><G><G><P><L><V><T><R><D><L><K><D><T><W><Y><L><I><G><I><V><S><W><G><D><N><C><G><Q><K><D><K><P><G><V><Y><T><Q><V><T><Y><Y><R><N><W><I><A><S><K><T><G><I>
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.<BOP>
Q6ZMR5
Q96L58
B3GT6_HUMAN
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
Homo
<M><K><L><L><R><R><A><W><R><R><R><A><A><L><G><L><G><T><L><A><L><C><G><A><A><L><L><Y><L><A><R><C><A><A><E><P><G><D><P><R><A><M><S><G><R><S><P><P><P><P><A><P><A><R><A><A><A><F><L><A><V><L><V><A><S><A><P><R><A><A><E><R><R><S><V><I><R><S><T><W><L><A><R><R><G><A><P><G><D><V><W><A><R><F><A><V><G><T><A><G><L><G><A><E><E><R><R><A><L><E><R><E><Q><A><R><H><G><D><L><L><L><L><P><A><L><R><D><A><Y><E><N><L><T><A><K><V><L><A><M><L><A><W><L><D><E><H><V><A><F><E><F><V><L><K><A><D><D><D><S><F><A><R><L><D><A><L><L><A><E><L><R><A><R><E><P><A><R><R><R><R><L><Y><W><G><F><F><S><G><R><G><R><V><K><P><G><G><R><W><R><E><A><A><W><Q><L><C><D><Y><Y><L><P><Y><A><L><G><G><G><Y><V><L><S><A><D><L><V><H><Y><L><R><L><S><R><D><Y><L><R><A><W><H><S><E><D><V><S><L><G><A><W><L><A><P><V><D><V><Q><R><E><H><D><P><R><F><D><T><E><Y><R><S><R><G><C><S><N><Q><Y><L><V><T><H><K><Q><S><L><E><D><M><L><E><K><H><A><T><L><A><R><E><G><R><L><C><K><R><E><V><Q><L><R><L><S><Y><V><Y><D><W><S><A><P><P><S><Q><C><C><Q><R><R><E><G><I><P>
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.<BOP>
Q96L58
P02649
APOE_HUMAN
Apolipoprotein E
Homo
<M><K><V><L><W><A><A><L><L><V><T><F><L><A><G><C><Q><A><K><V><E><Q><A><V><E><T><E><P><E><P><E><L><R><Q><Q><T><E><W><Q><S><G><Q><R><W><E><L><A><L><G><R><F><W><D><Y><L><R><W><V><Q><T><L><S><E><Q><V><Q><E><E><L><L><S><S><Q><V><T><Q><E><L><R><A><L><M><D><E><T><M><K><E><L><K><A><Y><K><S><E><L><E><E><Q><L><T><P><V><A><E><E><T><R><A><R><L><S><K><E><L><Q><A><A><Q><A><R><L><G><A><D><M><E><D><V><C><G><R><L><V><Q><Y><R><G><E><V><Q><A><M><L><G><Q><S><T><E><E><L><R><V><R><L><A><S><H><L><R><K><L><R><K><R><L><L><R><D><A><D><D><L><Q><K><R><L><A><V><Y><Q><A><G><A><R><E><G><A><E><R><G><L><S><A><I><R><E><R><L><G><P><L><V><E><Q><G><R><V><R><A><A><T><V><G><S><L><A><G><Q><P><L><Q><E><R><A><Q><A><W><G><E><R><L><R><A><R><M><E><E><M><G><S><R><T><R><D><R><L><D><E><V><K><E><Q><V><A><E><V><R><A><K><L><E><E><Q><A><Q><Q><I><R><L><Q><A><E><A><F><Q><A><R><L><K><S><W><F><E><P><L><V><E><D><M><Q><R><Q><W><A><G><L><V><E><K><V><Q><A><A><V><G><T><S><A><A><P><V><P><S><D><N><H>
(Microbial infection) Through its interaction with HCV envelope glycoprotein E2, participates in the attachment of HCV to HSPGs and other receptors (LDLr, VLDLr, and SR-B1) on the cell surface and to the assembly, maturation and infectivity of HCV viral particles . This interaction is probably promoted via the up-regulation of cellular autophagy by the virus .<BOP>
P02649
Q8NCU7
C2C4A_HUMAN
Protein FAM148A
Homo
<M><W><C><L><E><R><L><R><L><G><P><E><C><L><R><R><S><G><D><W><L><L><P><G><R><A><R><G><A><K><S><R><T><T><A><A><C><A><N><V><L><T><P><D><R><I><P><E><F><C><I><P><P><R><L><M><P><R><L><A><L><A><A><L><R><N><S><W><V><E><E><A><G><M><D><E><G><A><G><R><T><D><W><D><P><R><S><Q><A><A><L><S><L><P><H><L><P><R><V><R><T><A><Y><G><F><C><A><L><L><E><S><P><H><T><R><R><K><E><S><L><L><L><G><G><P><P><A><P><R><P><R><A><H><T><Y><G><G><G><G><G><P><D><A><L><L><G><T><L><R><V><P><R><A><P><G><P><A><T><P><A><A><P><G><C><P><R><P><P><Q><D><A><L><A><R><R><P><R><G><C><R><L><L><R><V><P><D><G><L><L><S><R><A><L><R><A><G><R><S><R><R><L><T><R><V><R><S><V><S><S><G><N><E><D><K><E><R><R><A><G><S><Q><S><P><A><R><A><P><S><T><S><P><P><S><S><R><V><P><F><P><E><R><L><E><A><E><G><T><V><A><L><G><R><A><G><D><A><L><R><L><A><A><E><Y><C><P><G><T><G><R><L><R><L><R><L><L><R><A><E><S><P><A><G><G><A><P><G><P><R><A><V><S><C><R><L><S><L><V><L><R><P><P><G><T><A><L><R><Q><C><S><T><V><V><G><R><S><R><K><A><S><F><D><Q><D><F><C><F><D><G><L><S><E><D><E><V><R><R><L><A><V><R><V><K><A><R><D><E><G><R><G><R><E><R><G><R><L><L><G><Q><G><E><L><S><L><G><A><L><L><L><L>
May be involved in inflammatory process. May regulate cell architecture and adhesion.<BOP>
Q8NCU7
Q9BXC0
HCAR1_HUMAN
G-protein coupled receptor 81
Homo
<M><Y><N><G><S><C><C><R><I><E><G><D><T><I><S><Q><V><M><P><P><L><L><I><V><A><F><V><L><G><A><L><G><N><G><V><A><L><C><G><F><C><F><H><M><K><T><W><K><P><S><T><V><Y><L><F><N><L><A><V><A><D><F><L><L><M><I><C><L><P><F><R><T><D><Y><Y><L><R><R><R><H><W><A><F><G><D><I><P><C><R><V><G><L><F><T><L><A><M><N><R><A><G><S><I><V><F><L><T><V><V><A><A><D><R><Y><F><K><V><V><H><P><H><H><A><V><N><T><I><S><T><R><V><A><A><G><I><V><C><T><L><W><A><L><V><I><L><G><T><V><Y><L><L><L><E><N><H><L><C><V><Q><E><T><A><V><S><C><E><S><F><I><M><E><S><A><N><G><W><H><D><I><M><F><Q><L><E><F><F><M><P><L><G><I><I><L><F><C><S><F><K><I><V><W><S><L><R><R><R><Q><Q><L><A><R><Q><A><R><M><K><K><A><T><R><F><I><M><V><V><A><I><V><F><I><T><C><Y><L><P><S><V><S><A><R><L><Y><F><L><W><T><V><P><S><S><A><C><D><P><S><V><H><G><A><L><H><I><T><L><S><F><T><Y><M><N><S><M><L><D><P><L><V><Y><Y><F><S><S><P><S><F><P><K><F><Y><N><K><L><K><I><C><S><L><K><P><K><Q><P><G><H><S><K><T><Q><R><P><E><E><M><P><I><S><N><L><G><R><R><S><C><I><S><V><A><N><S><F><Q><S><Q><S><D><G><Q><W><D><P><H><I><V><E><W><H>
Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.<BOP>
Q9BXC0
Q5T0T0
MARH8_HUMAN
RING-type E3 ubiquitin transferase MARCHF8
Homo
<M><S><M><P><L><H><Q><I><S><A><I><P><S><Q><D><A><I><S><A><R><V><Y><R><S><K><T><K><E><K><E><R><E><E><Q><N><E><K><T><L><G><H><F><M><S><H><S><S><N><I><S><K><A><G><S><P><P><S><A><S><A><P><A><P><V><S><S><F><S><R><T><S><I><T><P><S><S><Q><D><I><C><R><I><C><H><C><E><G><D><D><E><S><P><L><I><T><P><C><H><C><T><G><S><L><H><F><V><H><Q><A><C><L><Q><Q><W><I><K><S><S><D><T><R><C><C><E><L><C><K><Y><E><F><I><M><E><T><K><L><K><P><L><R><K><W><E><K><L><Q><M><T><S><S><E><R><R><K><I><M><C><S><V><T><F><H><V><I><A><I><T><C><V><V><W><S><L><Y><V><L><I><D><R><T><A><E><E><I><K><Q><G><Q><A><T><G><I><L><E><W><P><F><W><T><K><L><V><V><V><A><I><G><F><T><G><G><L><L><F><M><Y><V><Q><C><K><V><Y><V><Q><L><W><K><R><L><K><A><Y><N><R><V><I><Y><V><Q><N><C><P><E><T><S><K><K><N><I><F><E><K><S><P><L><T><E><P><N><F><E><N><K><H><G><Y><G><I><C><H><S><D><T><N><S><S><C><C><T><E><P><E><D><T><G><A><E><I><I><H><V>
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.<BOP>
Q5T0T0
Q15813
TBCE_HUMAN
Tubulin-folding cofactor E
Homo
<M><S><D><T><L><T><A><D><V><I><G><R><R><V><E><V><N><G><E><H><A><T><V><R><F><A><G><V><V><P><P><V><A><G><P><W><L><G><V><E><W><D><N><P><E><R><G><K><H><D><G><S><H><E><G><T><V><Y><F><K><C><R><H><P><T><G><G><S><F><I><R><P><N><K><V><N><F><G><T><D><F><L><T><A><I><K><N><R><Y><V><L><E><D><G><P><E><E><D><R><K><E><Q><I><V><T><I><G><N><K><P><V><E><T><I><G><F><D><S><I><M><K><Q><Q><S><Q><L><S><K><L><Q><E><V><S><L><R><N><C><A><V><S><C><A><G><E><K><G><G><V><A><E><A><C><P><N><I><R><K><V><D><L><S><K><N><L><L><S><S><W><D><E><V><I><H><I><A><D><Q><L><R><H><L><E><V><L><N><V><S><E><N><K><L><K><F><P><S><G><S><V><L><T><G><T><L><S><V><L><K><V><L><V><L><N><Q><T><G><I><T><W><A><E><V><L><R><C><V><A><G><C><P><G><L><E><E><L><Y><L><E><S><N><N><I><F><I><S><E><R><P><T><D><V><L><Q><T><V><K><L><L><D><L><S><S><N><Q><L><I><D><E><N><Q><L><Y><L><I><A><H><L><P><R><L><E><Q><L><I><L><S><D><T><G><I><S><S><L><H><F><P><D><A><G><I><G><C><K><T><S><M><F><P><S><L><K><Y><L><V><V><N><D><N><Q><I><S><Q><W><S><F><F><N><E><L><E><K><L><P><S><L><R><A><L><S><C><L><R><N><P><L><T><K><E><D><K><E><A><E><T><A><R><L><L><I><I><A><S><I><G><Q><L><K><T><L><N><K><C><E><I><L><P><E><E><R><R><R><A><E><L><D><Y><R><K><A><F><G><N><E><W><K><Q><A><G><G><H><K><D><P><E><K><N><R><L><S><E><E><F><L><T><A><H><P><R><Y><Q><F><L><C><L><K><Y><G><A><P><E><D><W><E><L><K><T><Q><Q><P><L><M><L><K><N><Q><L><L><T><L><K><I><K><Y><P><H><Q><L><D><Q><K><V><L><E><K><Q><L><P><G><S><M><T><I><Q><K><V><K><G><L><L><S><R><L><L><K><V><P><V><S><D><L><L><L><S><Y><E><S><P><K><K><P><G><R><E><I><E><L><E><N><D><L><K><S><L><Q><F><Y><S><V><E><N><G><D><C><L><L><V><R><W>
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.<BOP>
Q15813
Q99808
S29A1_HUMAN
Solute carrier family 29 member 1
Homo
<M><T><T><S><H><Q><P><Q><D><R><Y><K><A><V><W><L><I><F><F><M><L><G><L><G><T><L><L><P><W><N><F><F><M><T><A><T><Q><Y><F><T><N><R><L><D><M><S><Q><N><V><S><L><V><T><A><E><L><S><K><D><A><Q><A><S><A><A><P><A><A><P><L><P><E><R><N><S><L><S><A><I><F><N><N><V><M><T><L><C><A><M><L><P><L><L><L><F><T><Y><L><N><S><F><L><H><Q><R><I><P><Q><S><V><R><I><L><G><S><L><V><A><I><L><L><V><F><L><I><T><A><I><L><V><K><V><Q><L><D><A><L><P><F><F><V><I><T><M><I><K><I><V><L><I><N><S><F><G><A><I><L><Q><G><S><L><F><G><L><A><G><L><L><P><A><S><Y><T><A><P><I><M><S><G><Q><G><L><A><G><F><F><A><S><V><A><M><I><C><A><I><A><S><G><S><E><L><S><E><S><A><F><G><Y><F><I><T><A><C><A><V><I><I><L><T><I><I><C><Y><L><G><L><P><R><L><E><F><Y><R><Y><Y><Q><Q><L><K><L><E><G><P><G><E><Q><E><T><K><L><D><L><I><S><K><G><E><E><P><R><A><G><K><E><E><S><G><V><S><V><S><N><S><Q><P><T><N><E><S><H><S><I><K><A><I><L><K><N><I><S><V><L><A><F><S><V><C><F><I><F><T><I><T><I><G><M><F><P><A><V><T><V><E><V><K><S><S><I><A><G><S><S><T><W><E><R><Y><F><I><P><V><S><C><F><L><T><F><N><I><F><D><W><L><G><R><S><L><T><A><V><F><M><W><P><G><K><D><S><R><W><L><P><S><L><V><L><A><R><L><V><F><V><P><L><L><L><L><C><N><I><K><P><R><R><Y><L><T><V><V><F><E><H><D><A><W><F><I><F><F><M><A><A><F><A><F><S><N><G><Y><L><A><S><L><C><M><C><F><G><P><K><K><V><K><P><A><E><A><E><T><A><G><A><I><M><A><F><F><L><C><L><G><L><A><L><G><A><V><F><S><F><L><F><R><A><I><V>
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).<BOP>
Q99808
P78424
PO6F2_HUMAN
Retina-derived POU domain factor 1
Homo
<M><S><A><L><L><Q><D><P><M><I><A><G><Q><V><S><K><P><L><L><S><V><R><S><E><M><N><A><E><L><R><G><E><D><K><A><A><T><S><D><S><E><L><N><E><P><L><L><A><P><V><E><S><N><D><S><E><D><T><P><S><K><L><F><G><A><R><G><N><P><A><L><S><D><P><G><T><P><D><Q><H><Q><A><S><Q><T><H><P><P><F><P><V><G><P><Q><P><L><L><T><A><Q><Q><L><A><S><A><V><A><G><V><M><P><G><G><P><P><A><L><N><Q><P><I><L><I><P><F><N><M><A><G><Q><L><G><G><Q><Q><G><L><V><L><T><L><P><T><A><N><L><T><N><I><Q><G><L><V><A><A><A><A><A><G><G><I><M><T><L><P><L><Q><N><L><Q><A><T><S><S><L><N><S><Q><L><Q><Q><L><Q><L><Q><L><Q><Q><Q><Q><Q><Q><Q><Q><Q><Q><P><P><P><S><T><N><Q><H><P><Q><P><A><P><Q><A><P><S><Q><S><Q><Q><Q><P><L><Q><P><T><P><P><Q><Q><P><P><P><A><S><Q><Q><P><P><A><P><T><S><Q><L><Q><Q><A><P><Q><P><Q><Q><H><Q><P><H><S><H><S><Q><N><Q><N><Q><P><S><P><T><Q><Q><S><S><S><P><P><Q><K><P><S><Q><S><P><G><H><G><L><P><S><P><L><T><P><P><N><P><L><Q><L><V><N><N><P><L><A><S><Q><A><A><A><A><A><A><A><M><S><S><I><A><S><S><Q><A><F><G><N><A><L><S><S><L><Q><G><V><T><G><Q><L><V><T><N><A><Q><G><Q><I><I><G><T><I><P><L><M><P><N><P><G><P><S><S><Q><A><A><S><G><T><Q><G><L><Q><V><Q><P><I><T><P><Q><L><L><T><N><A><Q><G><Q><I><I><A><T><V><I><G><N><Q><I><L><P><V><I><N><T><Q><G><I><T><L><S><P><I><K><P><G><Q><Q><L><H><Q><P><S><Q><T><S><V><G><Q><A><A><S><Q><G><N><L><L><H><L><A><H><S><Q><A><S><M><S><Q><S><P><V><R><Q><A><S><S><S><S><S><S><S><S><S><S><S><A><L><S><V><G><Q><L><V><S><N><P><Q><T><A><A><G><E><V><D><G><V><N><L><E><E><I><R><E><F><A><K><A><F><K><I><R><R><L><S><L><G><L><T><Q><T><Q><V><G><Q><A><L><S><A><T><E><G><P><A><Y><S><Q><S><A><I><C><R><H><T><I><L><R><S><H><F><F><L><P><Q><E><A><Q><E><N><T><I><A><S><S><L><T><A><K><L><N><P><G><L><L><Y><P><A><R><F><E><K><L><D><I><T><P><K><S><A><Q><K><I><K><P><V><L><E><R><W><M><A><E><A><E><A><R><H><R><A><G><M><Q><N><L><T><E><F><I><G><S><E><P><S><K><K><R><K><R><R><T><S><F><T><P><Q><A><L><E><I><L><N><A><H><F><E><K><N><T><H><P><S><G><Q><E><M><T><E><I><A><E><K><L><N><Y><D><R><E><V><V><R><V><W><F><C><N><K><R><Q><A><L><K><N><T><I><K><R><L><K><Q><H><E><P><A><T><A><V><P><L><E><P><L><T><D><S><L><E><E><N><S>
Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.<BOP>
P78424
Q8N2I2
ZN619_HUMAN
Zinc finger protein 619
Homo
<M><G><Q><P><A><P><Y><A><E><G><P><I><Q><G><G><D><A><G><E><L><C><K><C><D><F><L><V><S><I><S><I><P><Q><T><R><S><D><I><P><A><G><A><R><R><S><S><M><G><P><R><S><L><D><T><C><W><G><R><G><P><E><R><H><V><H><R><L><E><C><N><G><V><I><F><T><H><R><N><L><C><L><P><G><G><K><T><K><T><E><N><E><E><K><T><A><Q><L><N><I><S><K><E><S><E><S><H><R><L><I><V><E><G><L><L><M><D><V><P><Q><H><P><D><F><K><D><R><L><E><K><S><Q><L><H><D><T><G><N><K><T><K><I><G><D><C><T><D><L><T><V><Q><D><H><E><S><S><T><T><E><R><E><E><I><A><R><K><L><E><E><S><S><V><S><T><H><L><I><T><K><Q><G><F><A><K><E><Q><V><F><Y><K><C><G><E><C><G><S><Y><Y><N><P><H><S><D><F><H><L><H><Q><R><V><H><T><N><E><K><P><Y><T><C><K><E><C><G><K><T><F><R><Y><N><S><K><L><S><R><H><Q><K><I><H><T><G><E><K><P><Y><S><C><E><E><C><G><Q><A><F><S><Q><N><S><H><L><L><Q><H><Q><K><L><H><G><G><Q><R><P><Y><E><C><T><D><C><G><K><T><F><S><Y><N><S><K><L><I><R><H><Q><R><I><H><T><G><E><K><P><F><K><C><K><E><C><G><K><A><F><S><C><S><Y><D><C><I><I><H><E><R><I><H><N><G><E><K><P><Y><E><C><K><E><C><G><K><S><L><S><S><N><S><V><L><I><Q><H><Q><R><I><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><H><R><S><S><V><F><L><Q><H><Q><R><F><H><T><G><E><Q><L><Y><K><C><N><E><C><W><K><T><F><S><C><S><S><R><F><I><V><H><Q><R><I><H><N><G><E><K><P><Y><E><C><Q><E><C><G><K><T><F><S><Q><K><I><T><L><V><Q><H><Q><R><V><H><T><G><E><K><P><Y><E><C><K><E><C><G><K><A><F><R><W><N><A><S><F><I><Q><H><Q><K><W><H><T><R><K><K><L><I><N><G><T><G><L><S><A><V><K><P><Y><C><P><C><A><I><L><S><P><L><P><P><Q><H><T><C><S><A><L><A><P><P><G><P><P><L><S><S><S><H><A><V><V><L><P><P><S><V><P><F><F><L><L><L><P><S><S><E><K><A><N><P><S><P><V><Q><I><A><H><F><F><Q><D><L><A><F><P><G><K><S><S><L><Q><S><P><N><P><L><S><H><S><L>
May be involved in transcriptional regulation.<BOP>
Q8N2I2
Q53GQ0
DHB12_HUMAN
Short chain dehydrogenase/reductase family 12C member 1
Homo
<M><E><S><A><L><P><A><A><G><F><L><Y><W><V><G><A><G><T><V><A><Y><L><A><L><R><I><S><Y><S><L><F><T><A><L><R><V><W><G><V><G><N><E><A><G><V><G><P><G><L><G><E><W><A><V><V><T><G><S><T><D><G><I><G><K><S><Y><A><E><E><L><A><K><H><G><M><K><V><V><L><I><S><R><S><K><D><K><L><D><Q><V><S><S><E><I><K><E><K><F><K><V><E><T><R><T><I><A><V><D><F><A><S><E><D><I><Y><D><K><I><K><T><G><L><A><G><L><E><I><G><I><L><V><N><N><V><G><M><S><Y><E><Y><P><E><Y><F><L><D><V><P><D><L><D><N><V><I><K><K><M><I><N><I><N><I><L><S><V><C><K><M><T><Q><L><V><L><P><G><M><V><E><R><S><K><G><A><I><L><N><I><S><S><G><S><G><M><L><P><V><P><L><L><T><I><Y><S><A><T><K><T><F><V><D><F><F><S><Q><C><L><H><E><E><Y><R><S><K><G><V><F><V><Q><S><V><L><P><Y><F><V><A><T><K><L><A><K><I><R><K><P><T><L><D><K><P><S><P><E><T><F><V><K><S><A><I><K><T><V><G><L><Q><S><R><T><N><G><Y><L><I><H><A><L><M><G><S><I><I><S><N><L><P><S><W><I><Y><L><K><I><V><M><N><M><N><K><S><T><R><A><H><Y><L><K><K><T><K><K><N>
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.<BOP>
Q53GQ0
P51810
GP143_HUMAN
Ocular albinism type 1 protein
Homo
<M><A><S><P><R><L><G><T><F><C><C><P><T><R><D><A><A><T><Q><L><V><L><S><F><Q><P><R><A><F><H><A><L><C><L><G><S><G><G><L><R><L><A><L><G><L><L><Q><L><L><P><G><R><R><P><A><G><P><G><S><P><A><T><S><P><P><A><S><V><R><I><L><R><A><A><A><A><C><D><L><L><G><C><L><G><M><V><I><R><S><T><V><W><L><G><F><P><N><F><V><D><S><V><S><D><M><N><H><T><E><I><W><P><A><A><F><C><V><G><S><A><M><W><I><Q><L><L><Y><S><A><C><F><W><W><L><F><C><Y><A><V><D><A><Y><L><V><I><R><R><S><A><G><L><S><T><I><L><L><Y><H><I><M><A><W><G><L><A><T><L><L><C><V><E><G><A><A><M><L><Y><Y><P><S><V><S><R><C><E><R><G><L><D><H><A><I><P><H><Y><V><T><M><Y><L><P><L><L><L><V><L><V><A><N><P><I><L><F><Q><K><T><V><T><A><V><A><S><L><L><K><G><R><Q><G><I><Y><T><E><N><E><R><R><M><G><A><V><I><K><I><R><F><F><K><I><M><L><V><L><I><I><C><W><L><S><N><I><I><N><E><S><L><L><F><Y><L><E><M><Q><T><D><I><N><G><G><S><L><K><P><V><R><T><A><A><K><T><T><W><F><I><M><G><I><L><N><P><A><Q><G><F><L><L><S><L><A><F><Y><G><W><T><G><C><S><L><G><F><Q><S><P><R><K><E><I><Q><W><E><S><L><T><T><S><A><A><E><G><A><H><P><S><P><L><M><P><H><E><N><P><A><S><G><K><V><S><Q><V><G><G><Q><T><S><D><E><A><L><S><M><L><S><E><G><S><D><A><S><T><I><E><I><H><T><A><S><E><S><C><N><K><N><E><G><D><P><A><L><P><T><H><G><D><L>
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.<BOP>
P51810
P08908
5HT1A_HUMAN
Serotonin receptor 1A
Homo
<M><D><V><L><S><P><G><Q><G><N><N><T><T><S><P><P><A><P><F><E><T><G><G><N><T><T><G><I><S><D><V><T><V><S><Y><Q><V><I><T><S><L><L><L><G><T><L><I><F><C><A><V><L><G><N><A><C><V><V><A><A><I><A><L><E><R><S><L><Q><N><V><A><N><Y><L><I><G><S><L><A><V><T><D><L><M><V><S><V><L><V><L><P><M><A><A><L><Y><Q><V><L><N><K><W><T><L><G><Q><V><T><C><D><L><F><I><A><L><D><V><L><C><C><T><S><S><I><L><H><L><C><A><I><A><L><D><R><Y><W><A><I><T><D><P><I><D><Y><V><N><K><R><T><P><R><R><A><A><A><L><I><S><L><T><W><L><I><G><F><L><I><S><I><P><P><M><L><G><W><R><T><P><E><D><R><S><D><P><D><A><C><T><I><S><K><D><H><G><Y><T><I><Y><S><T><F><G><A><F><Y><I><P><L><L><L><M><L><V><L><Y><G><R><I><F><R><A><A><R><F><R><I><R><K><T><V><K><K><V><E><K><T><G><A><D><T><R><H><G><A><S><P><A><P><Q><P><K><K><S><V><N><G><E><S><G><S><R><N><W><R><L><G><V><E><S><K><A><G><G><A><L><C><A><N><G><A><V><R><Q><G><D><D><G><A><A><L><E><V><I><E><V><H><R><V><G><N><S><K><E><H><L><P><L><P><S><E><A><G><P><T><P><C><A><P><A><S><F><E><R><K><N><E><R><N><A><E><A><K><R><K><M><A><L><A><R><E><R><K><T><V><K><T><L><G><I><I><M><G><T><F><I><L><C><W><L><P><F><F><I><V><A><L><V><L><P><F><C><E><S><S><C><H><M><P><T><L><L><G><A><I><I><N><W><L><G><Y><S><N><S><L><L><N><P><V><I><Y><A><Y><F><N><K><D><F><Q><N><A><F><K><K><I><I><K><C><K><F><C><R><Q>
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.<BOP>
P08908
O96008
TOM40_HUMAN
p38.5
Homo
<M><G><N><V><L><A><A><S><S><P><P><A><G><P><P><P><P><P><A><P><A><L><V><G><L><P><P><P><P><P><S><P><P><G><F><T><L><P><P><L><G><G><S><L><G><A><G><T><S><T><S><R><S><S><E><R><T><P><G><A><A><T><A><S><A><S><G><A><A><E><D><G><A><C><G><C><L><P><N><P><G><T><F><E><E><C><H><R><K><C><K><E><L><F><P><I><Q><M><E><G><V><K><L><T><V><N><K><G><L><S><N><H><F><Q><V><N><H><T><V><A><L><S><T><I><G><E><S><N><Y><H><F><G><V><T><Y><V><G><T><K><Q><L><S><P><T><E><A><F><P><V><L><V><G><D><M><D><N><S><G><S><L><N><A><Q><V><I><H><Q><L><G><P><G><L><R><S><K><M><A><I><Q><T><Q><Q><S><K><F><V><N><W><Q><V><D><G><E><Y><R><G><S><D><F><T><A><A><V><T><L><G><N><P><D><V><L><V><G><S><G><I><L><V><A><H><Y><L><Q><S><I><T><P><C><L><A><L><G><G><E><L><V><Y><H><R><R><P><G><E><E><G><T><V><M><S><L><A><G><K><Y><T><L><N><N><W><L><A><T><V><T><L><G><Q><A><G><M><H><A><T><Y><Y><H><K><A><S><D><Q><L><Q><V><G><V><E><F><E><A><S><T><R><M><Q><D><T><S><V><S><F><G><Y><Q><L><D><L><P><K><A><N><L><L><F><K><G><S><V><D><S><N><W><I><V><G><A><T><L><E><K><K><L><P><P><L><P><L><T><L><A><L><G><A><F><L><N><H><R><K><N><K><F><Q><C><G><F><G><L><T><I><G>
Channel-forming protein essential for import of protein precursors into mitochondria . Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria .<BOP>
O96008
Q96DT0
LEG12_HUMAN
Galectin-related inhibitor of proliferation
Homo
<M><S><Q><P><S><G><G><R><A><P><G><T><R><I><Y><S><W><S><C><P><T><V><M><S><P><G><E><K><L><D><P><I><P><D><S><F><I><L><Q><P><P><V><F><H><P><V><V><P><Y><V><T><T><I><F><G><G><L><H><A><G><K><M><V><M><L><Q><G><V><V><P><L><D><A><H><R><F><Q><V><D><F><Q><C><G><C><S><L><C><P><R><P><D><I><A><F><H><F><N><P><R><F><H><T><T><K><P><H><V><I><C><N><T><L><H><G><G><R><W><Q><R><E><A><R><W><P><H><L><A><L><R><R><G><S><S><F><L><I><L><F><L><F><G><N><E><E><V><K><V><S><V><N><G><Q><H><F><L><H><F><R><Y><R><L><P><L><S><H><V><D><T><L><G><I><F><G><D><I><L><V><E><A><V><G><F><L><N><I><N><P><F><V><E><G><S><R><E><Y><P><A><G><H><P><F><L><L><M><S><P><R><L><E><V><P><C><S><H><A><L><P><Q><G><L><S><P><G><Q><V><I><I><V><R><G><L><V><L><Q><E><P><K><H><F><T><V><S><L><R><D><Q><A><A><H><A><P><V><T><L><R><A><S><F><A><D><R><T><L><A><W><I><S><R><W><G><Q><K><K><L><I><S><A><P><F><L><F><Y><P><Q><R><F><F><E><V><L><L><L><F><Q><E><G><G><L><K><L><A><L><N><G><Q><G><L><G><A><T><S><M><N><Q><Q><A><L><E><Q><L><R><E><L><R><I><S><G><S><V><Q><L><Y><C><V><H><S>
Binds lactose. May participate in the apoptosis of adipocytes.<BOP>
Q96DT0
Q9UBP9
GULP1_HUMAN
Protein GULP
Homo
<M><N><R><A><F><S><R><K><K><D><K><T><W><M><H><T><P><E><A><L><S><K><H><F><I><P><Y><N><A><K><F><L><G><S><T><E><V><E><Q><P><K><G><T><E><V><V><R><D><A><V><R><K><L><K><F><A><R><H><I><K><K><S><E><G><Q><K><I><P><K><V><E><L><Q><I><S><I><Y><G><V><K><I><L><E><P><K><T><K><E><V><Q><H><N><C><Q><L><H><R><I><S><F><C><A><D><D><K><T><D><K><R><I><F><T><F><I><C><K><D><S><E><S><N><K><H><L><C><Y><V><F><D><S><E><K><C><A><E><E><I><T><L><T><I><G><Q><A><F><D><L><A><Y><R><K><F><L><E><S><G><G><K><D><V><E><T><R><K><Q><I><A><G><L><Q><K><R><I><Q><D><L><E><T><E><N><M><E><L><K><N><K><V><Q><D><L><E><N><Q><L><R><I><T><Q><V><S><A><P><P><A><G><S><M><T><P><K><S><P><S><T><D><I><F><D><M><I><P><F><S><P><I><S><H><Q><S><S><M><P><T><R><N><G><T><Q><P><P><P><V><P><S><R><S><T><E><I><K><R><D><L><F><G><A><E><P><F><D><P><F><N><C><G><A><A><D><F><P><P><D><I><Q><S><K><L><D><E><M><Q><E><G><F><K><M><G><L><T><L><E><G><T><V><F><C><L><D><P><L><D><S><R><C>
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.<BOP>
Q9UBP9
Q6P9B6
MEAK7_HUMAN
TLD domain-containing protein 1
Homo
<M><G><N><S><R><S><R><V><G><R><S><F><C><S><Q><F><L><P><E><E><Q><A><E><I><D><Q><L><F><D><A><L><S><S><D><K><N><S><P><N><V><S><S><K><S><F><S><L><K><A><L><Q><N><H><V><G><E><A><L><P><P><E><M><V><T><R><L><Y><D><G><M><R><R><V><D><L><T><G><K><A><K><G><P><S><E><N><V><S><Q><E><Q><F><T><A><S><M><S><H><L><L><K><G><N><S><E><E><K><S><L><M><I><M><K><M><I><S><A><T><E><G><P><V><K><A><R><E><V><Q><K><F><T><E><D><L><V><G><S><V><V><H><V><L><S><H><R><Q><E><L><R><G><W><T><G><K><E><A><P><G><P><N><P><R><V><Q><V><L><A><A><Q><L><L><S><D><M><K><L><Q><D><G><K><R><L><L><G><P><Q><W><L><D><Y><D><C><D><R><A><V><I><E><D><W><V><F><R><V><P><H><V><A><I><F><L><S><V><V><I><C><K><G><F><L><I><L><C><S><S><L><D><L><T><T><L><V><P><E><R><Q><V><D><Q><G><R><G><F><E><S><I><L><D><V><L><S><V><M><Y><I><N><A><Q><L><P><R><E><Q><R><H><R><W><C><L><L><F><S><S><E><L><H><G><H><S><F><S><Q><L><C><G><H><I><T><H><R><G><P><C><V><A><V><L><E><D><H><D><K><H><V><F><G><G><F><A><S><C><S><W><E><V><K><P><Q><F><Q><G><D><N><R><C><F><L><F><S><I><C><P><S><M><A><V><Y><T><H><T><G><Y><N><D><H><Y><M><Y><L><N><H><G><Q><Q><T><I><P><N><G><L><G><M><G><G><Q><H><N><Y><F><G><L><W><V><D><V><D><F><G><K><G><H><S><R><A><K><P><T><C><T><T><Y><N><S><P><Q><L><S><A><Q><E><N><F><Q><F><D><K><M><E><V><W><A><V><G><D><P><S><E><E><Q><L><A><K><G><N><K><S><I><L><D><A><D><P><E><A><Q><A><L><L><E><I><S><G><H><S><R><H><S><E><G><L><R><E><V><P><D><D><E>
Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration . Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome .<BOP>
Q6P9B6
Q9BVK6
TMED9_HUMAN
p25
Homo
<M><A><V><E><L><G><V><L><L><V><R><P><R><P><G><T><G><L><G><R><V><M><R><T><L><L><L><V><L><W><L><A><T><R><G><S><A><L><Y><F><H><I><G><E><T><E><K><K><C><F><I><E><E><I><P><D><E><T><M><V><I><G><N><Y><R><T><Q><L><Y><D><K><Q><R><E><E><Y><Q><P><A><T><P><G><L><G><M><F><V><E><V><K><D><P><E><D><K><V><I><L><A><R><Q><Y><G><S><E><G><R><F><T><F><T><S><H><T><P><G><E><H><Q><I><C><L><H><S><N><S><T><K><F><S><L><F><A><G><G><M><L><R><V><H><L><D><I><Q><V><G><E><H><A><N><D><Y><A><E><I><A><A><K><D><K><L><S><E><L><Q><L><R><V><R><Q><L><V><E><Q><V><E><Q><I><Q><K><E><Q><N><Y><Q><R><W><R><E><E><R><F><R><Q><T><S><E><S><T><N><Q><R><V><L><W><W><S><I><L><Q><T><L><I><L><V><A><I><G><V><W><Q><M><R><H><L><K><S><F><F><E><A><K><K><L><V>
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.<BOP>
Q9BVK6
Q96IY1
NSL1_HUMAN
Kinetochore-associated protein NSL1 homolog
Homo
<M><A><G><S><P><E><L><V><V><L><D><P><P><W><D><K><E><L><A><A><G><T><E><S><Q><A><L><V><S><A><T><P><R><E><D><F><R><V><R><C><T><S><K><R><A><V><T><E><M><L><Q><L><C><G><R><F><V><Q><K><L><G><D><A><L><P><E><E><I><R><E><P><A><L><R><D><A><Q><W><T><F><E><S><A><V><Q><E><N><I><S><I><N><G><Q><A><W><Q><E><A><S><D><N><C><F><M><D><S><D><I><K><V><L><E><D><Q><F><D><E><I><I><V><D><I><A><T><K><R><K><Q><Y><P><R><K><I><L><E><C><V><I><K><T><I><K><A><K><Q><E><I><L><K><Q><Y><H><P><V><V><H><P><L><D><L><K><Y><D><P><D><P><A><P><H><M><E><N><L><K><C><R><G><E><T><V><A><K><E><I><S><E><A><M><K><S><L><P><A><L><I><E><Q><G><E><G><F><S><Q><V><L><R><M><Q><P><V><I><H><L><Q><R><I><H><Q><E><V><F><S><S><C><H><R><K><P><D><A><K><P><E><N><F><I><T><Q><I><E><T><T><P><T><E><T><A><S><R><K><T><S><D><M><V><L><K><R><K><Q><T><K><D><C><P><Q><R><K><W><Y><P><L><R><P><K><K><I><N><L><D><T>
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.<BOP>
Q96IY1
Q16572
VACHT_HUMAN
Solute carrier family 18 member 3
Homo
<M><E><S><A><E><P><A><G><Q><A><R><A><A><A><T><K><L><S><E><A><V><G><A><A><L><Q><E><P><R><R><Q><R><R><L><V><L><V><I><V><C><V><A><L><L><L><D><N><M><L><Y><M><V><I><V><P><I><V><P><D><Y><I><A><H><M><R><G><G><G><E><G><P><T><R><T><P><E><V><W><E><P><T><L><P><L><P><T><P><A><N><A><S><A><Y><T><A><N><T><S><A><S><P><T><A><A><W><P><A><G><S><A><L><R><P><R><Y><P><T><E><S><E><D><V><K><I><G><V><L><F><A><S><K><A><I><L><Q><L><L><V><N><P><L><S><G><P><F><I><D><R><M><S><Y><D><V><P><L><L><I><G><L><G><V><M><F><A><S><T><V><L><F><A><F><A><E><D><Y><A><T><L><F><A><A><R><S><L><Q><G><L><G><S><A><F><A><D><T><S><G><I><A><M><I><A><D><K><Y><P><E><E><P><E><R><S><R><A><L><G><V><A><L><A><F><I><S><F><G><S><L><V><A><P><P><F><G><G><I><L><Y><E><F><A><G><K><R><V><P><F><L><V><L><A><A><V><S><L><F><D><A><L><L><L><L><A><V><A><K><P><F><S><A><A><A><R><A><R><A><N><L><P><V><G><T><P><I><H><R><L><M><L><D><P><Y><I><A><V><V><A><G><A><L><T><T><C><N><I><P><L><A><F><L><E><P><T><I><A><T><W><M><K><H><T><M><A><A><S><E><W><E><M><G><M><A><W><L><P><A><F><V><P><H><V><L><G><V><Y><L><T><V><R><L><A><A><R><Y><P><H><L><Q><W><L><Y><G><A><L><G><L><A><V><I><G><A><S><S><C><I><V><P><A><C><R><S><F><A><P><L><V><V><S><L><C><G><L><C><F><G><I><A><L><V><D><T><A><L><L><P><T><L><A><F><L><V><D><V><R><H><V><S><V><Y><G><S><V><Y><A><I><A><D><I><S><Y><S><V><A><Y><A><L><G><P><I><V><A><G><H><I><V><H><S><L><G><F><E><Q><L><S><L><G><M><G><L><A><N><L><L><Y><A><P><V><L><L><L><L><R><N><V><G><L><L><T><R><S><R><S><E><R><D><V><L><L><D><E><P><P><Q><G><L><Y><D><A><V><R><L><R><E><R><P><V><S><G><Q><D><G><E><P><R><S><P><P><G><P><F><D><A><C><E><D><D><Y><N><Y><Y><Y><T><R><S>
Involved in acetylcholine transport into synaptic vesicles.<BOP>
Q16572
O75023
LIRB5_HUMAN
Leukocyte immunoglobulin-like receptor 8
Homo
<M><T><L><T><L><S><V><L><I><C><L><G><L><S><V><G><P><R><T><C><V><Q><A><G><T><L><P><K><P><T><L><W><A><E><P><A><S><V><I><A><R><G><K><P><V><T><L><W><C><Q><G><P><L><E><T><E><E><Y><R><L><D><K><E><G><L><P><W><A><R><K><R><Q><N><P><L><E><P><G><A><K><A><K><F><H><I><P><S><T><V><Y><D><S><A><G><R><Y><R><C><Y><Y><E><T><P><A><G><W><S><E><P><S><D><P><L><E><L><V><A><T><G><F><Y><A><E><P><T><L><L><A><L><P><S><P><V><V><A><S><G><G><N><V><T><L><Q><C><D><T><L><D><G><L><L><T><F><V><L><V><E><E><E><Q><K><L><P><R><T><L><Y><S><Q><K><L><P><K><G><P><S><Q><A><L><F><P><V><G><P><V><T><P><S><C><R><W><R><F><R><C><Y><Y><Y><Y><R><K><N><P><Q><V><W><S><N><P><S><D><L><L><E><I><L><V><P><G><V><S><R><K><P><S><L><L><I><P><Q><G><S><V><V><A><R><G><G><S><L><T><L><Q><C><R><S><D><V><G><Y><D><I><F><V><L><Y><K><E><G><E><H><D><L><V><Q><G><S><G><Q><Q><P><Q><A><G><L><S><Q><A><N><F><T><L><G><P><V><S><R><S><H><G><G><Q><Y><R><C><Y><G><A><H><N><L><S><P><R><W><S><A><P><S><D><P><L><D><I><L><I><A><G><L><I><P><D><I><P><A><L><S><V><Q><P><G><P><K><V><A><S><G><E><N><V><T><L><L><C><Q><S><W><H><Q><I><D><T><F><F><L><T><K><E><G><A><A><H><P><P><L><C><L><K><S><K><Y><Q><S><Y><R><H><Q><A><E><F><S><M><S><P><V><T><S><A><Q><G><G><T><Y><R><C><Y><S><A><I><R><S><Y><P><Y><L><L><S><S><P><S><Y><P><Q><E><L><V><V><S><G><P><S><G><D><P><S><L><S><P><T><G><S><T><P><T><P><G><P><E><D><Q><P><L><T><P><T><G><L><D><P><Q><S><G><L><G><R><H><L><G><V><V><T><G><V><S><V><A><F><V><L><L><L><F><L><L><L><F><L><L><L><R><H><R><H><Q><S><K><H><R><T><S><A><H><F><Y><R><P><A><G><A><A><G><P><E><P><K><D><Q><G><L><Q><K><R><A><S><P><V><A><D><I><Q><E><E><I><L><N><A><A><V><K><D><T><Q><P><K><D><G><V><E><M><D><A><P><A><A><A><S><E><A><P><Q><D><V><T><Y><A><Q><L><H><S><L><T><L><R><R><E><A><T><E><P><P><P><S><Q><E><R><E><P><P><A><E><P><S><I><Y><A><P><L><A><I><H>
May act as receptor for class I MHC antigens.<BOP>
O75023
Q16082
HSPB2_HUMAN
DMPK-binding protein
Homo
<M><S><G><R><S><V><P><H><A><H><P><A><T><A><E><Y><E><F><A><N><P><S><R><L><G><E><Q><R><F><G><E><G><L><L><P><E><E><I><L><T><P><T><L><Y><H><G><Y><Y><V><R><P><R><A><A><P><A><G><E><G><S><R><A><G><A><S><E><L><R><L><S><E><G><K><F><Q><A><F><L><D><V><S><H><F><T><P><D><E><V><T><V><R><T><V><D><N><L><L><E><V><S><A><R><H><P><Q><R><L><D><R><H><G><F><V><S><R><E><F><C><R><T><Y><V><L><P><A><D><V><D><P><W><R><V><R><A><A><L><S><H><D><G><I><L><N><L><E><A><P><R><G><G><R><H><L><D><T><E><V><N><E><V><Y><I><S><L><L><P><A><P><P><D><P><E><E><E><E><E><A><A><I><V><E><P>
May regulate the kinase DMPK.<BOP>
Q16082
Q49A26
GLYR1_HUMAN
Putative oxidoreductase GLYR1
Homo
<M><A><A><V><S><L><R><L><G><D><L><V><W><G><K><L><G><R><Y><P><P><W><P><G><K><I><V><N><P><P><K><D><L><K><K><P><R><G><K><K><C><F><F><V><K><F><F><G><T><E><D><H><A><W><I><K><V><E><Q><L><K><P><Y><H><A><H><K><E><E><M><I><K><I><N><K><G><K><R><F><Q><Q><A><V><D><A><V><E><E><F><L><R><R><A><K><G><K><D><Q><T><S><S><H><N><S><S><D><D><K><N><R><R><N><S><S><E><E><R><S><R><P><N><S><G><D><E><K><R><K><L><S><L><S><E><G><K><V><K><K><N><M><G><E><G><K><K><R><V><S><S><G><S><S><E><R><G><S><K><S><P><L><K><R><A><Q><E><Q><S><P><R><K><R><G><R><P><P><K><D><E><K><D><L><T><I><P><E><S><S><T><V><K><G><M><M><A><G><P><M><A><A><F><K><W><Q><P><T><A><S><E><P><V><K><D><A><D><P><H><F><H><H><F><L><L><S><Q><T><E><K><P><A><V><C><Y><Q><A><I><T><K><K><L><K><I><C><E><E><E><T><G><S><T><S><I><Q><A><A><D><S><T><A><V><N><G><S><I><T><P><T><D><K><K><I><G><F><L><G><L><G><L><M><G><S><G><I><V><S><N><L><L><K><M><G><H><T><V><T><V><W><N><R><T><A><E><K><C><D><L><F><I><Q><E><G><A><R><L><G><R><T><P><A><E><V><V><S><T><C><D><I><T><F><A><C><V><S><D><P><K><A><A><K><D><L><V><L><G><P><S><G><V><L><Q><G><I><R><P><G><K><C><Y><V><D><M><S><T><V><D><A><D><T><V><T><E><L><A><Q><V><I><V><S><R><G><G><R><F><L><E><A><P><V><S><G><N><Q><Q><L><S><N><D><G><M><L><V><I><L><A><A><G><D><R><G><L><Y><E><D><C><S><S><C><F><Q><A><M><G><K><T><S><F><F><L><G><E><V><G><N><A><A><K><M><M><L><I><V><N><M><V><Q><G><S><F><M><A><T><I><A><E><G><L><T><L><A><Q><V><T><G><Q><S><Q><Q><T><L><L><D><I><L><N><Q><G><Q><L><A><S><I><F><L><D><Q><K><C><Q><N><I><L><Q><G><N><F><K><P><D><F><Y><L><K><Y><I><Q><K><D><L><R><L><A><I><A><L><G><D><A><V><N><H><P><T><P><M><A><A><A><A><N><E><V><Y><K><R><A><K><A><L><D><Q><S><D><N><D><M><S><A><V><Y><R><A><Y><I><H>
Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression . Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation . Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA . Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes . Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 . With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation . Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling . Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 . The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 .<BOP>
Q49A26
H0YL14
TM250_HUMAN
Herpes virus UL25-binding protein
Homo
<M><P><V><M><P><I><P><R><R><V><R><S><F><H><G><P><H><T><T><C><L><H><A><A><C><G><P><V><R><A><S><H><L><A><R><T><K><Y><N><N><F><D><V><Y><I><K><T><R><W><L><Y><G><F><I><R><F><L><L><Y><F><S><C><S><L><F><T><A><A><L><W><G><A><L><A><A><L><F><C><L><Q><Y><L><G><V><R><V><L><L><R><F><Q><R><K><L><S><V><L><L><L><L><L><G><R><R><R><V><D><F><R><L><V><N><E><L><L><V><Y><G><I><H><V><T><M><L><L><V><G><G><L><G><W><C><F><M><V><F><V><D><M>
(Microbial infection) Promotes human herpes simplex virus 1/HHV-1 proliferation.<BOP>
H0YL14
O60684
IMA7_HUMAN
Karyopherin subunit alpha-6
Homo
<M><E><T><M><A><S><P><G><K><D><N><Y><R><M><K><S><Y><K><N><N><A><L><N><P><E><E><M><R><R><R><R><E><E><E><G><I><Q><L><R><K><Q><K><R><E><Q><Q><L><F><K><R><R><N><V><E><L><I><N><E><E><A><A><M><F><D><S><L><L><M><D><S><Y><V><S><S><T><T><G><E><S><V><I><T><R><E><M><V><E><M><L><F><S><D><D><S><D><L><Q><L><A><T><T><Q><K><F><R><K><L><L><S><K><E><P><S><P><P><I><D><E><V><I><N><T><P><R><V><V><D><R><F><V><E><F><L><K><R><N><E><N><C><T><L><Q><F><E><A><A><W><A><L><T><N><I><A><S><G><T><S><Q><Q><T><K><I><V><I><E><A><G><A><V><P><I><F><I><E><L><L><N><S><D><F><E><D><V><Q><E><Q><A><V><W><A><L><G><N><I><A><G><D><S><S><V><C><R><D><Y><V><L><N><C><S><I><L><N><P><L><L><T><L><L><T><K><S><T><R><L><T><M><T><R><N><A><V><W><A><L><S><N><L><C><R><G><K><N><P><P><P><E><F><A><K><V><S><P><C><L><P><V><L><S><R><L><L><F><S><S><D><S><D><L><L><A><D><A><C><W><A><L><S><Y><L><S><D><G><P><N><E><K><I><Q><A><V><I><D><S><G><V><C><R><R><L><V><E><L><L><M><H><N><D><Y><K><V><A><S><P><A><L><R><A><V><G><N><I><V><T><G><D><D><I><Q><T><Q><V><I><L><N><C><S><A><L><P><C><L><L><H><L><L><S><S><P><K><E><S><I><R><K><E><A><C><W><T><I><S><N><I><T><A><G><N><R><A><Q><I><Q><A><V><I><D><A><N><I><F><P><V><L><I><E><I><L><Q><K><A><E><F><R><T><R><K><E><A><A><W><A><I><T><N><A><T><S><G><G><T><P><E><Q><I><R><Y><L><V><S><L><G><C><I><K><P><L><C><D><L><L><T><V><M><D><S><K><I><V><Q><V><A><L><N><G><L><E><N><I><L><R><L><G><E><Q><E><G><K><R><S><G><S><G><V><N><P><Y><C><G><L><I><E><E><A><Y><G><L><D><K><I><E><F><L><Q><S><H><E><N><Q><E><I><Y><Q><K><A><F><D><L><I><E><H><Y><F><G><V><E><D><D><D><S><S><L><A><P><Q><V><D><E><T><Q><Q><Q><F><I><F><Q><Q><P><E><A><P><M><E><G><F><Q><L>
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.<BOP>
O60684
P06881
CALCA_HUMAN
Calcitonin gene-related peptide I
Homo
<M><G><F><Q><K><F><S><P><F><L><A><L><S><I><L><V><L><L><Q><A><G><S><L><H><A><A><P><F><R><S><A><L><E><S><S><P><A><D><P><A><T><L><S><E><D><E><A><R><L><L><L><A><A><L><V><Q><D><Y><V><Q><M><K><A><S><E><L><E><Q><E><Q><E><R><E><G><S><R><I><I><A><Q><K><R><A><C><D><T><A><T><C><V><T><H><R><L><A><G><L><L><S><R><S><G><G><V><V><K><N><N><F><V><P><T><N><V><G><S><K><A><F><G><R><R><R><R><D><L><Q><A>
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.<BOP>
P06881
P10301
RRAS_HUMAN
p23
Homo
<M><S><S><G><A><A><S><G><T><G><R><G><R><P><R><G><G><G><P><G><P><G><D><P><P><P><S><E><T><H><K><L><V><V><V><G><G><G><G><V><G><K><S><A><L><T><I><Q><F><I><Q><S><Y><F><V><S><D><Y><D><P><T><I><E><D><S><Y><T><K><I><C><S><V><D><G><I><P><A><R><L><D><I><L><D><T><A><G><Q><E><E><F><G><A><M><R><E><Q><Y><M><R><A><G><H><G><F><L><L><V><F><A><I><N><D><R><Q><S><F><N><E><V><G><K><L><F><T><Q><I><L><R><V><K><D><R><D><D><F><P><V><V><L><V><G><N><K><A><D><L><E><S><Q><R><Q><V><P><R><S><E><A><S><A><F><G><A><S><H><H><V><A><Y><F><E><A><S><A><K><L><R><L><N><V><D><E><A><F><E><Q><L><V><R><A><V><R><K><Y><Q><E><Q><E><L><P><P><S><P><P><S><A><P><R><K><K><G><G><G><C><P><C><V><L><L>
Regulates the organization of the actin cytoskeleton . With OSPBL3, modulates integrin beta-1 (ITGB1) activity .<BOP>
P10301
Q68D86
C102B_HUMAN
Coiled-coil domain-containing protein 102B
Homo
<M><N><L><D><S><I><H><R><L><I><E><E><T><Q><I><F><Q><M><Q><Q><S><S><I><K><S><R><G><D><M><V><A><P><A><S><P><P><R><D><T><C><N><T><C><F><P><L><H><G><L><Q><S><H><A><A><H><N><F><C><A><H><S><Y><N><T><N><K><W><D><I><C><E><E><L><R><L><R><E><L><E><E><V><K><A><R><A><A><Q><M><E><K><T><M><R><W><W><S><D><C><T><A><N><W><R><E><K><W><S><K><V><R><A><E><R><N><S><A><R><E><E><G><R><Q><L><R><I><K><L><E><M><A><M><K><E><L><S><T><L><K><K><K><Q><S><L><P><P><Q><K><E><A><L><E><A><K><V><T><Q><D><L><K><L><P><G><F><V><E><E><S><C><E><H><T><D><Q><F><Q><L><S><S><Q><M><H><E><S><I><R><E><Y><L><V><K><R><Q><F><S><T><K><E><D><T><N><N><K><E><Q><G><V><V><I><D><S><L><K><L><S><E><E><M><K><P><N><L><D><G><V><D><L><F><N><N><G><G><S><G><N><G><E><T><K><T><G><L><R><L><K><A><I><N><L><P><L><E><N><E><V><T><E><I><S><A><L><Q><V><H><L><D><E><F><Q><K><I><L><W><K><E><R><E><M><R><T><A><L><E><K><E><I><E><R><L><E><S><A><L><S><L><W><K><W><K><Y><E><E><L><K><E><S><K><P><K><N><V><K><E><F><D><I><L><L><G><Q><H><N><D><E><M><Q><E><L><S><G><N><I><K><E><E><S><K><S><Q><N><S><K><D><R><V><I><C><E><L><R><A><E><L><E><R><L><Q><A><E><N><T><S><E><W><D><K><R><E><I><L><E><R><E><K><Q><G><L><E><R><E><N><R><R><L><K><I><Q><V><K><E><M><E><E><L><L><D><K><K><N><R><L><S><A><N><S><Q><S><P><D><F><K><M><S><Q><I><D><L><Q><E><K><N><Q><E><L><L><N><L><Q><H><A><Y><Y><K><L><N><R><Q><Y><Q><A><N><I><A><E><L><T><H><A><N><N><R><V><D><Q><N><E><A><E><V><K><K><L><R><L><R><V><E><E><L><K><Q><G><L><N><Q><K><E><D><E><L><D><D><S><L><N><Q><I><R><K><L><Q><R><S><L><D><E><E><K><E><R><N><E><N><L><E><T><E><L><R><H><L><Q><N><W>
During interphase, forms fibers at the proximal ends of centrioles to maintain centrosome cohesion . During mitosis, dissociates from the centrosome following phosphorylation to allow centrosome separation . Contributes to CROCC/rootletin filament formation .<BOP>
Q68D86
O75935
DCTN3_HUMAN
Dynactin complex subunit 22 kDa subunit
Homo
<M><A><G><L><T><D><L><Q><R><L><Q><A><R><V><E><E><L><E><R><W><V><Y><G><P><G><G><A><R><G><S><R><K><V><A><D><G><L><V><K><V><Q><V><A><L><G><N><I><S><S><K><R><E><R><V><K><I><L><Y><K><K><I><E><D><L><I><K><Y><L><D><P><E><Y><I><D><R><I><A><I><P><D><A><S><K><L><Q><F><I><L><A><E><E><Q><F><I><L><S><Q><V><A><L><L><E><Q><V><N><A><L><V><P><M><L><D><S><A><H><I><K><A><V><P><E><H><A><A><R><L><Q><R><L><A><Q><I><H><I><Q><Q><Q><D><Q><C><V><E><I><T><E><E><S><K><A><L><L><E><E><Y><N><K><T><T><M><L><L><S><K><Q><F><V><Q><W><D><E><L><L><C><Q><L><E><A><A><T><Q><V><K><P><A><E><E>
Together with dynein may be involved in spindle assembly and cytokinesis.<BOP>
O75935
Q9HCC0
MCCB_HUMAN
3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta
Homo
<M><W><A><V><L><R><L><A><L><R><P><C><A><R><A><S><P><A><G><P><R><A><Y><H><G><D><S><V><A><S><L><G><T><Q><P><D><L><G><S><A><L><Y><Q><E><N><Y><K><Q><M><K><A><L><V><N><Q><L><H><E><R><V><E><H><I><K><L><G><G><G><E><K><A><R><A><L><H><I><S><R><G><K><L><L><P><R><E><R><I><D><N><L><I><D><P><G><S><P><F><L><E><L><S><Q><F><A><G><Y><Q><L><Y><D><N><E><E><V><P><G><G><G><I><I><T><G><I><G><R><V><S><G><V><E><C><M><I><I><A><N><D><A><T><V><K><G><G><A><Y><Y><P><V><T><V><K><K><Q><L><R><A><Q><E><I><A><M><Q><N><R><L><P><C><I><Y><L><V><D><S><G><G><A><Y><L><P><R><Q><A><D><V><F><P><D><R><D><H><F><G><R><T><F><Y><N><Q><A><I><M><S><S><K><N><I><A><Q><I><A><V><V><M><G><S><C><T><A><G><G><A><Y><V><P><A><M><A><D><E><N><I><I><V><R><K><Q><G><T><I><F><L><A><G><P><P><L><V><K><A><A><T><G><E><E><V><S><A><E><D><L><G><G><A><D><L><H><C><R><K><S><G><V><S><D><H><W><A><L><D><D><H><H><A><L><H><L><T><R><K><V><V><R><N><L><N><Y><Q><K><K><L><D><V><T><I><E><P><S><E><E><P><L><F><P><A><D><E><L><Y><G><I><V><G><A><N><L><K><R><S><F><D><V><R><E><V><I><A><R><I><V><D><G><S><R><F><T><E><F><K><A><F><Y><G><D><T><L><V><T><G><F><A><R><I><F><G><Y><P><V><G><I><V><G><N><N><G><V><L><F><S><E><S><A><K><K><G><T><H><F><V><Q><L><C><C><Q><R><N><I><P><L><L><F><L><Q><N><I><T><G><F><M><V><G><R><E><Y><E><A><E><G><I><A><K><D><G><A><K><M><V><A><A><V><A><C><A><Q><V><P><K><I><T><L><I><I><G><G><S><Y><G><A><G><N><Y><G><M><C><G><R><A><Y><S><P><R><F><L><Y><I><W><P><N><A><R><I><S><V><M><G><G><E><Q><A><A><N><V><L><A><T><I><T><K><D><Q><R><A><R><E><G><K><Q><F><S><S><A><D><E><A><A><L><K><E><P><I><I><K><K><F><E><E><E><G><N><P><Y><Y><S><S><A><R><V><W><D><D><G><I><I><D><P><A><D><T><R><L><V><L><G><L><S><F><S><A><A><L><N><A><P><I><E><K><T><D><F><G><I><F><R><M>
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.<BOP>
Q9HCC0
Q16695
H31T_HUMAN
Histone H3.4
Homo
<M><A><R><T><K><Q><T><A><R><K><S><T><G><G><K><A><P><R><K><Q><L><A><T><K><V><A><R><K><S><A><P><A><T><G><G><V><K><K><P><H><R><Y><R><P><G><T><V><A><L><R><E><I><R><R><Y><Q><K><S><T><E><L><L><I><R><K><L><P><F><Q><R><L><M><R><E><I><A><Q><D><F><K><T><D><L><R><F><Q><S><S><A><V><M><A><L><Q><E><A><C><E><S><Y><L><V><G><L><F><E><D><T><N><L><C><V><I><H><A><K><R><V><T><I><M><P><K><D><I><Q><L><A><R><R><I><R><G><E><R><A>
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<BOP>
Q16695
A0A589
TVB43_HUMAN
T cell receptor beta variable 4-3
Homo
<M><G><C><R><L><L><C><C><A><V><L><C><L><L><G><A><V><P><M><E><T><G><V><T><Q><T><P><R><H><L><V><M><G><M><T><N><K><K><S><L><K><C><E><Q><H><L><G><H><N><A><M><Y><W><Y><K><Q><S><A><K><K><P><L><E><L><M><F><V><Y><S><L><E><E><R><V><E><N><N><S><V><P><S><R><F><S><P><E><C><P><N><S><S><H><L><F><L><H><L><H><T><L><Q><P><E><D><S><A><L><Y><L><C><A><S><S><Q>
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement
A0A589
P34981
TRFR_HUMAN
Thyroliberin receptor
Homo
<M><E><N><E><T><V><S><E><L><N><Q><T><Q><L><Q><P><R><A><V><V><A><L><E><Y><Q><V><V><T><I><L><L><V><L><I><I><C><G><L><G><I><V><G><N><I><M><V><V><L><V><V><M><R><T><K><H><M><R><T><P><T><N><C><Y><L><V><S><L><A><V><A><D><L><M><V><L><V><A><A><G><L><P><N><I><T><D><S><I><Y><G><S><W><V><Y><G><Y><V><G><C><L><C><I><T><Y><L><Q><Y><L><G><I><N><A><S><S><C><S><I><T><A><F><T><I><E><R><Y><I><A><I><C><H><P><I><K><A><Q><F><L><C><T><F><S><R><A><K><K><I><I><I><F><V><W><A><F><T><S><L><Y><C><M><L><W><F><F><L><L><D><L><N><I><S><T><Y><K><D><A><I><V><I><S><C><G><Y><K><I><S><R><N><Y><Y><S><P><I><Y><L><M><D><F><G><V><F><Y><V><V><P><M><I><L><A><T><V><L><Y><G><F><I><A><R><I><L><F><L><N><P><I><P><S><D><P><K><E><N><S><K><T><W><K><N><D><S><T><H><Q><N><T><N><L><N><V><N><T><S><N><R><C><F><N><S><T><V><S><S><R><K><Q><V><T><K><M><L><A><V><V><V><I><L><F><A><L><L><W><M><P><Y><R><T><L><V><V><V><N><S><F><L><S><S><P><F><Q><E><N><W><F><L><L><F><C><R><I><C><I><Y><L><N><S><A><I><N><P><V><I><Y><N><L><M><S><Q><K><F><R><A><A><F><R><K><L><C><N><C><K><Q><K><P><T><E><K><P><A><N><Y><S><V><A><L><N><Y><S><V><I><K><E><S><D><H><F><S><T><E><L><D><D><I><T><V><T><D><T><Y><L><S><A><T><K><V><S><F><D><D><T><C><L><A><S><E><V><S><F><S><Q><S>
Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<BOP>
P34981
Q5JTV8
TOIP1_HUMAN
Lamin-associated protein 1B
Homo
<M><A><G><D><G><R><R><A><E><A><V><R><E><G><W><G><V><Y><V><T><P><R><A><P><I><R><E><G><R><G><R><L><A><P><Q><N><G><G><S><S><D><A><P><A><Y><R><T><P><P><S><R><Q><G><R><R><E><V><R><F><S><D><E><P><P><E><V><Y><G><D><F><E><P><L><V><A><K><E><R><S><P><V><G><K><R><T><R><L><E><E><F><R><S><D><S><A><K><E><E><V><R><E><S><A><Y><Y><L><R><S><R><Q><R><R><Q><P><R><P><Q><E><T><E><E><M><K><T><R><R><T><T><R><L><Q><Q><Q><H><S><E><Q><P><P><L><Q><P><S><P><V><M><T><R><R><G><L><R><D><S><H><S><S><E><E><D><E><A><S><S><Q><T><D><L><S><Q><T><I><S><K><K><T><V><R><S><I><Q><E><A><P><V><S><E><D><L><V><I><R><L><R><R><P><P><L><R><Y><P><R><Y><E><A><T><S><V><Q><Q><K><V><N><F><S><E><E><G><E><T><E><E><D><D><Q><D><S><S><H><S><S><V><T><T><V><K><A><R><S><R><D><S><D><E><S><G><D><K><T><T><R><S><S><S><Q><Y><I><E><S><F><W><Q><S><S><Q><S><Q><N><F><T><A><H><D><K><Q><P><S><V><L><S><S><G><Y><Q><K><T><P><Q><E><W><A><P><Q><T><A><R><I><R><T><R><M><Q><N><D><S><I><L><K><S><E><L><G><N><Q><S><P><S><T><S><S><R><Q><V><T><G><Q><P><Q><N><A><S><F><V><K><R><N><R><W><W><L><L><P><L><I><A><A><L><A><S><G><S><F><W><F><F><S><T><P><E><V><E><T><T><A><V><Q><E><F><Q><N><Q><M><N><Q><L><K><N><K><Y><Q><G><Q><D><E><K><L><W><K><R><S><Q><T><F><L><E><K><H><L><N><S><S><H><P><R><S><Q><P><A><I><L><L><L><T><A><A><R><D><A><E><E><A><L><R><C><L><S><E><Q><I><A><D><A><Y><S><S><F><R><S><V><R><A><I><R><I><D><G><T><D><K><A><T><Q><D><S><D><T><V><K><L><E><V><D><Q><E><L><S><N><G><F><K><N><G><Q><N><A><A><V><V><H><R><F><E><S><F><P><A><G><S><T><L><I><F><Y><K><Y><C><D><H><E><N><A><A><F><K><D><V><A><L><V><L><T><V><L><L><E><E><E><T><L><G><T><S><L><G><L><K><E><V><E><E><K><V><R><D><F><L><K><V><K><F><T><N><S><N><T><P><N><S><Y><N><H><M><D><P><D><K><L><N><G><L><W><S><R><I><S><H><L><V><L><P><V><Q><P><E><N><A><L><K><R><G><I><C><L>
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.<BOP>
Q5JTV8
P0DP03
HVC05_HUMAN
Immunoglobulin heavy variable 3-30-5
Homo
<M><E><F><G><L><S><W><V><F><L><V><A><L><L><R><G><V><Q><C><Q><V><Q><L><V><E><S><G><G><G><V><V><Q><P><G><R><S><L><R><L><S><C><A><A><S><G><F><T><F><S><S><Y><G><M><H><W><V><R><Q><A><P><G><K><G><L><E><W><V><A><V><I><S><Y><D><G><S><N><K><Y><Y><A><D><S><V><K><G><R><F><T><I><S><R><D><N><S><K><N><T><L><Y><L><Q><M><N><S><L><R><A><E><D><T><A><V><Y><Y><C><A><K>
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
P0DP03
Q9GZM6
OR8D2_HUMAN
Olfactory receptor-like protein JCG2
Homo
<M><A><T><S><N><H><S><S><G><A><E><F><I><L><A><G><L><T><Q><R><P><E><L><Q><L><P><L><F><L><L><F><L><G><I><Y><V><V><T><V><V><G><N><L><G><M><I><F><L><I><A><L><S><S><Q><L><Y><P><P><V><Y><Y><F><L><S><H><L><S><F><I><D><L><C><Y><S><S><V><I><T><P><K><M><L><V><N><F><V><P><E><E><N><I><I><S><F><L><E><C><I><T><Q><L><Y><F><F><L><I><F><V><I><A><E><G><Y><L><L><T><A><M><E><Y><D><R><Y><V><A><I><C><R><P><L><L><Y><N><I><V><M><S><H><R><V><C><S><I><M><M><A><V><V><Y><S><L><G><F><L><W><A><T><V><H><T><T><R><M><S><V><L><S><F><C><R><S><H><T><V><S><H><Y><F><C><D><I><L><P><L><L><T><L><S><C><S><S><T><H><I><N><E><I><L><L><F><I><I><G><G><V><N><T><L><A><T><T><L><A><V><L><I><S><Y><A><F><I><F><S><S><I><L><G><I><H><S><T><E><G><Q><S><K><A><F><G><T><C><S><S><H><L><L><A><V><G><I><F><F><G><S><I><T><F><M><Y><F><K><P><P><S><S><T><T><M><E><K><E><K><V><S><S><V><F><Y><I><T><I><I><P><M><L><N><P><L><I><Y><S><L><R><N><K><D><V><K><N><A><L><K><K><M><T><R><G><R><Q><S><S>
Odorant receptor (Potential). May be involved in taste perception.<BOP>
Q9GZM6
O75333
TBX10_HUMAN
T-box transcription factor TBX10
Homo
<M><A><A><F><L><S><A><G><L><G><I><L><A><P><S><E><T><Y><P><L><P><T><T><S><S><G><W><E><P><R><L><G><S><P><F><P><S><G><P><C><T><S><S><T><G><A><Q><A><V><A><E><P><T><G><Q><G><P><K><N><P><R><V><S><R><V><T><V><Q><L><E><M><K><P><L><W><E><E><F><N><Q><L><G><T><E><M><I><V><T><K><A><G><R><R><M><F><P><P><F><Q><V><K><I><L><G><M><D><S><L><A><D><Y><A><L><L><M><D><F><I><P><L><D><D><K><R><Y><R><Y><A><F><H><S><S><A><W><L><V><A><G><K><A><D><P><A><T><P><G><R><V><H><F><H><P><D><S><P><A><K><G><A><Q><W><M><R><Q><I><V><S><F><D><K><L><K><L><T><N><N><L><L><D><D><N><G><H><I><I><L><N><S><M><H><R><Y><Q><P><R><F><H><V><V><F><V><D><P><R><K><D><S><E><R><Y><A><Q><E><N><F><K><S><F><I><F><T><E><T><Q><F><T><A><V><T><A><Y><Q><N><H><R><I><T><Q><L><K><I><A><S><N><P><F><A><K><G><F><R><E><S><D><L><D><S><W><P><V><A><P><R><P><L><L><S><V><P><A><R><S><H><S><S><L><S><P><C><V><L><K><G><A><T><D><R><E><K><D><P><N><K><A><S><A><S><T><S><K><T><P><A><W><L><H><H><Q><L><L><P><P><P><E><V><L><L><A><P><A><T><Y><R><P><V><T><Y><Q><S><L><Y><S><G><A><P><S><H><L><G><I><P><R><T><R><P><A><P><Y><P><L><P><N><I><R><A><D><R><D><Q><G><G><L><P><L><P><A><G><L><G><L><L><S><P><T><V><V><C><L><G><P><G><Q><D><S><Q>
Probable transcriptional regulator involved in developmental processes.<BOP>
O75333
P83876
TXN4A_HUMAN
Thioredoxin-like U5 snRNP protein U5-15kD
Homo
<M><S><Y><M><L><P><H><L><H><N><G><W><Q><V><D><Q><A><I><L><S><E><E><D><R><V><V><V><I><R><F><G><H><D><W><D><P><T><C><M><K><M><D><E><V><L><Y><S><I><A><E><K><V><K><N><F><A><V><I><Y><L><V><D><I><T><E><V><P><D><F><N><K><M><Y><E><L><Y><D><P><C><T><V><M><F><F><F><R><N><K><H><I><M><I><D><L><G><T><G><N><N><N><K><I><N><W><A><M><E><D><K><Q><E><M><V><D><I><I><E><T><V><Y><R><G><A><R><K><G><R><G><L><V><V><S><P><K><D><Y><S><T><K><Y><R><Y>
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).<BOP>
P83876
Q9GZU1
MCLN1_HUMAN
Transient receptor potential channel mucolipin 1
Homo
<M><T><A><P><A><G><P><R><G><S><E><T><E><R><L><L><T><P><N><P><G><Y><G><T><Q><A><G><P><S><P><A><P><P><T><P><P><E><E><E><D><L><R><R><R><L><K><Y><F><F><M><S><P><C><D><K><F><R><A><K><G><R><K><P><C><K><L><M><L><Q><V><V><K><I><L><V><V><T><V><Q><L><I><L><F><G><L><S><N><Q><L><A><V><T><F><R><E><E><N><T><I><A><F><R><H><L><F><L><L><G><Y><S><D><G><A><D><D><T><F><A><A><Y><T><R><E><Q><L><Y><Q><A><I><F><H><A><V><D><Q><Y><L><A><L><P><D><V><S><L><G><R><Y><A><Y><V><R><G><G><G><D><P><W><T><N><G><S><G><L><A><L><C><Q><R><Y><Y><H><R><G><H><V><D><P><A><N><D><T><F><D><I><D><P><M><V><V><T><D><C><I><Q><V><D><P><P><E><R><P><P><P><P><P><S><D><D><L><T><L><L><E><S><S><S><S><Y><K><N><L><T><L><K><F><H><K><L><V><N><V><T><I><H><F><R><L><K><T><I><N><L><Q><S><L><I><N><N><E><I><P><D><C><Y><T><F><S><V><L><I><T><F><D><N><K><A><H><S><G><R><I><P><I><S><L><E><T><Q><A><H><I><Q><E><C><K><H><P><S><V><F><Q><H><G><D><N><S><F><R><L><L><F><D><V><V><V><I><L><T><C><S><L><S><F><L><L><C><A><R><S><L><L><R><G><F><L><L><Q><N><E><F><V><G><F><M><W><R><Q><R><G><R><V><I><S><L><W><E><R><L><E><F><V><N><G><W><Y><I><L><L><V><T><S><D><V><L><T><I><S><G><T><I><M><K><I><G><I><E><A><K><N><L><A><S><Y><D><V><C><S><I><L><L><G><T><S><T><L><L><V><W><V><G><V><I><R><Y><L><T><F><F><H><N><Y><N><I><L><I><A><T><L><R><V><A><L><P><S><V><M><R><F><C><C><C><V><A><V><I><Y><L><G><Y><C><F><C><G><W><I><V><L><G><P><Y><H><V><K><F><R><S><L><S><M><V><S><E><C><L><F><S><L><I><N><G><D><D><M><F><V><T><F><A><A><M><Q><A><Q><Q><G><R><S><S><L><V><W><L><F><S><Q><L><Y><L><Y><S><F><I><S><L><F><I><Y><M><V><L><S><L><F><I><A><L><I><T><G><A><Y><D><T><I><K><H><P><G><G><A><G><A><E><E><S><E><L><Q><A><Y><I><A><Q><C><Q><D><S><P><T><S><G><K><F><R><R><G><S><G><S><A><C><S><L><L><C><C><C><G><R><D><P><S><E><E><H><S><L><L><V><N>
May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase.<BOP>
Q9GZU1
O15498
YKT6_HUMAN
Synaptobrevin homolog YKT6
Homo
<M><K><L><Y><S><L><S><V><L><Y><K><G><E><A><K><V><V><L><L><K><A><A><Y><D><V><S><S><F><S><F><F><Q><R><S><S><V><Q><E><F><M><T><F><T><S><Q><L><I><V><E><R><S><S><K><G><T><R><A><S><V><K><E><Q><D><Y><L><C><H><V><Y><V><R><N><D><S><L><A><G><V><V><I><A><D><N><E><Y><P><S><R><V><A><F><T><L><L><E><K><V><L><D><E><F><S><K><Q><V><D><R><I><D><W><P><V><G><S><P><A><T><I><H><Y><P><A><L><D><G><H><L><S><R><Y><Q><N><P><R><E><A><D><P><M><T><K><V><Q><A><E><L><D><E><T><K><I><I><L><H><N><T><M><E><S><L><L><E><R><G><E><K><L><D><D><L><V><S><K><S><E><V><L><G><T><Q><S><K><A><F><Y><K><T><A><R><K><Q><N><S><C><C><A><I><M>
Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.<BOP>
O15498
Q9Y617
SERC_HUMAN
Phosphohydroxythreonine aminotransferase
Homo
<M><D><A><P><R><Q><V><V><N><F><G><P><G><P><A><K><L><P><H><S><V><L><L><E><I><Q><K><E><L><L><D><Y><K><G><V><G><I><S><V><L><E><M><S><H><R><S><S><D><F><A><K><I><I><N><N><T><E><N><L><V><R><E><L><L><A><V><P><D><N><Y><K><V><I><F><L><Q><G><G><G><C><G><Q><F><S><A><V><P><L><N><L><I><G><L><K><A><G><R><C><A><D><Y><V><V><T><G><A><W><S><A><K><A><A><E><E><A><K><K><F><G><T><I><N><I><V><H><P><K><L><G><S><Y><T><K><I><P><D><P><S><T><W><N><L><N><P><D><A><S><Y><V><Y><Y><C><A><N><E><T><V><H><G><V><E><F><D><F><I><P><D><V><K><G><A><V><L><V><C><D><M><S><S><N><F><L><S><K><P><V><D><V><S><K><F><G><V><I><F><A><G><A><Q><K><N><V><G><S><A><G><V><T><V><V><I><V><R><D><D><L><L><G><F><A><L><R><E><C><P><S><V><L><E><Y><K><V><Q><A><G><N><S><S><L><Y><N><T><P><P><C><F><S><I><Y><V><M><G><L><V><L><E><W><I><K><N><N><G><G><A><A><A><M><E><K><L><S><S><I><K><S><Q><T><I><Y><E><I><I><D><N><S><Q><G><F><Y><V><C><P><V><E><P><Q><N><R><S><K><M><N><I><P><F><R><I><G><N><A><K><G><D><D><A><L><E><K><R><F><L><D><K><A><L><E><L><N><M><L><S><L><K><G><H><R><S><V><G><G><I><R><A><S><L><Y><N><A><V><T><I><E><D><V><Q><K><L><A><A><F><M><K><K><F><L><E><M><H><Q><L>
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<BOP>
Q9Y617
P33260
CP2CI_HUMAN
Cytochrome P450-6b/29c
Homo
<M><D><P><A><V><A><L><V><L><C><L><S><C><L><F><L><L><S><L><W><R><Q><S><S><G><R><G><R><L><P><S><G><P><T><P><L><P><I><I><G><N><I><L><Q><L><D><V><K><D><M><S><K><S><L><T><N><F><S><K><V><Y><G><P><V><F><T><V><Y><F><G><L><K><P><I><V><V><L><H><G><Y><E><A><V><K><E><A><L><I><D><H><G><E><E><F><S><G><R><G><S><F><P><V><A><E><K><V><N><K><G><L><G><I><L><F><S><N><G><K><R><W><K><E><I><R><R><F><C><L><M><T><L><R><N><F><G><M><G><K><R><S><I><E><D><R><V><Q><E><E><A><R><C><L><V><E><E><L><R><K><T><N><A><S><P><C><D><P><T><F><I><L><G><C><A><P><C><N><V><I><C><S><V><I><F><H><D><R><F><D><Y><K><D><Q><R><F><L><N><L><M><E><K><F><N><E><N><L><R><I><L><S><S><P><W><I><Q><V><C><N><N><F><P><A><L><I><D><Y><L><P><G><S><H><N><K><I><A><E><N><F><A><Y><I><K><S><Y><V><L><E><R><I><K><E><H><Q><E><S><L><D><M><N><S><A><R><D><F><I><D><C><F><L><I><K><M><E><Q><E><K><H><N><Q><Q><S><E><F><T><V><E><S><L><I><A><T><V><T><D><M><F><G><A><G><T><E><T><T><S><T><T><L><R><Y><G><L><L><L><L><L><K><Y><P><E><V><T><A><K><V><Q><E><E><I><E><C><V><V><G><R><N><R><S><P><C><M><Q><D><R><S><H><M><P><Y><T><D><A><V><V><H><E><I><Q><R><Y><I><D><L><L><P><T><N><L><P><H><A><V><T><C><D><V><K><F><K><N><Y><L><I><P><K><G><T><T><I><I><T><S><L><T><S><V><L><H><N><D><K><E><F><P><N><P><E><M><F><D><P><G><H><F><L><D><K><S><G><N><F><K><K><S><D><Y><F><M><P><F><S><A><G><K><R><M><C><M><G><E><G><L><A><R><M><E><L><F><L><F><L><T><T><I><L><Q><N><F><N><L><K><S><Q><V><D><P><K><D><I><D><I><T><P><I><A><N><A><F><G><R><V><P><P><L><Y><Q><L><C><F><I><P><V>
A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).<BOP>
P33260
D6R901
U17LL_HUMAN
Ubiquitin carboxyl-terminal hydrolase 17-like protein 21
Homo
<M><E><E><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><N><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><M><L><T><L><L><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><P><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><T><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><S><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
D6R901
Q9UNW8
GP132_HUMAN
G2 accumulation protein
Homo
<M><C><P><M><L><L><K><N><G><Y><N><G><N><A><T><P><V><T><T><T><A><P><W><A><S><L><G><L><S><A><K><T><C><N><N><V><S><F><E><E><S><R><I><V><L><V><V><V><Y><S><A><V><C><T><L><G><V><P><A><N><C><L><T><A><W><L><A><L><L><Q><V><L><Q><G><N><V><L><A><V><Y><L><L><C><L><A><L><C><E><L><L><Y><T><G><T><L><P><L><W><V><I><Y><I><R><N><Q><H><R><W><T><L><G><L><L><A><C><K><V><T><A><Y><I><F><F><C><N><I><Y><V><S><I><L><F><L><C><C><I><S><C><D><R><F><V><A><V><V><Y><A><L><E><S><R><G><R><R><R><R><R><T><A><I><L><I><S><A><C><I><F><I><L><V><G><I><V><H><Y><P><V><F><Q><T><E><D><K><E><T><C><F><D><M><L><Q><M><D><S><R><I><A><G><Y><Y><Y><A><R><F><T><V><G><F><A><I><P><L><S><I><I><A><F><T><N><H><R><I><F><R><S><I><K><Q><S><M><G><L><S><A><A><Q><K><A><K><V><K><H><S><A><I><A><V><V><V><I><F><L><V><C><F><A><P><Y><H><L><V><L><L><V><K><A><A><A><F><S><Y><Y><R><G><D><R><N><A><M><C><G><L><E><E><R><L><Y><T><A><S><V><V><F><L><C><L><S><T><V><N><G><V><A><D><P><I><I><Y><V><L><A><T><D><H><S><R><Q><E><V><S><R><I><H><K><G><W><K><E><W><S><M><K><T><D><V><T><R><L><T><H><S><R><D><T><E><E><L><Q><S><P><V><A><L><A><D><H><Y><T><F><S><R><P><V><H><P><P><G><S><P><C><P><A><K><R><L><I><E><E><S><C>
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.<BOP>
Q9UNW8
Q8NG85
OR2L3_HUMAN
Olfactory receptor 2L3
Homo
<M><E><N><Y><N><Q><T><S><T><D><F><I><L><L><G><F><F><P><P><S><R><I><G><L><F><L><F><I><L><I><V><F><I><F><L><M><A><L><I><G><N><L><S><M><I><L><L><I><F><L><D><T><H><L><H><T><P><M><Y><F><L><L><S><Q><L><S><L><I><D><L><N><Y><I><S><T><I><V><P><K><M><A><S><D><F><L><S><G><N><K><S><I><S><F><T><G><C><G><I><Q><S><F><F><F><S><A><L><G><G><A><E><A><L><L><L><A><S><M><A><Y><D><R><Y><I><A><I><C><F><P><L><H><Y><P><I><R><M><S><K><R><M><C><V><L><M><I><T><G><S><W><I><I><G><S><I><N><A><C><A><H><T><V><Y><V><L><H><I><P><Y><C><Q><S><R><A><I><N><H><F><F><C><D><V><P><A><M><V><T><L><A><C><M><D><T><W><V><Y><E><G><T><V><F><L><S><T><T><I><F><L><V><F><P><F><I><A><I><S><C><S><Y><G><R><V><L><L><A><V><Y><H><M><K><S><A><E><G><R><K><K><A><Y><L><T><C><S><T><H><L><T><V><V><T><F><Y><Y><A><P><F><V><Y><T><Y><L><R><P><R><S><L><R><S><P><T><E><D><K><V><L><A><V><F><Y><T><T><L><T><P><M><L><N><P><I><I><Y><S><L><R><N><K><E><V><M><G><A><L><T><R><V><S><Q><R><I><C><S><G><K><M>
Odorant receptor.<BOP>
Q8NG85
Q6DKK2
TTC19_HUMAN
Tetratricopeptide repeat protein 19, mitochondrial
Homo
<M><F><R><L><L><S><W><S><L><G><R><G><F><L><R><A><A><G><R><R><C><R><G><C><S><A><R><L><L><P><G><L><A><G><G><P><G><P><E><V><Q><V><P><P><S><R><V><A><P><H><G><R><G><P><G><L><L><P><L><L><A><A><L><A><W><F><S><R><P><A><A><A><E><E><E><E><Q><Q><G><A><D><G><A><A><A><E><D><G><A><D><E><A><E><A><E><I><I><Q><L><L><K><R><A><K><L><S><I><M><K><D><E><P><E><E><A><E><L><I><L><H><D><A><L><R><L><A><Y><Q><T><D><N><K><K><A><I><T><Y><T><Y><D><L><M><A><N><L><A><F><I><R><G><Q><L><E><N><A><E><Q><L><F><K><A><T><M><S><Y><L><L><G><G><G><M><K><Q><E><D><N><A><I><I><E><I><S><L><K><L><A><S><I><Y><A><A><Q><N><R><Q><E><F><A><V><A><G><Y><E><F><C><I><S><T><L><E><E><K><I><E><R><E><K><E><L><A><E><D><I><M><S><V><E><E><K><A><N><T><H><L><L><L><G><M><C><L><D><A><C><A><R><Y><L><L><F><S><K><Q><P><S><Q><A><Q><R><M><Y><E><K><A><L><Q><I><S><E><E><I><Q><G><E><R><H><P><Q><T><I><V><L><M><S><D><L><A><T><T><L><D><A><Q><G><R><F><D><E><A><Y><I><Y><M><Q><R><A><S><D><L><A><R><Q><I><N><H><P><E><L><H><M><V><L><S><N><L><A><A><V><L><M><H><R><E><R><Y><T><Q><A><K><E><I><Y><Q><E><A><L><K><Q><A><K><L><K><K><D><E><I><S><V><Q><H><I><R><E><E><L><A><E><L><S><K><K><S><R><P><L><T><N><S><V><K><L>
Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1 . Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity .<BOP>
Q6DKK2
Q9Y333
LSM2_HUMAN
snRNP core Sm-like protein Sm-x5
Homo
<M><L><F><Y><S><F><F><K><S><L><V><G><K><D><V><V><V><E><L><K><N><D><L><S><I><C><G><T><L><H><S><V><D><Q><Y><L><N><I><K><L><T><D><I><S><V><T><D><P><E><K><Y><P><H><M><L><S><V><K><N><C><F><I><R><G><S><V><V><R><Y><V><Q><L><P><A><D><E><V><D><T><Q><L><L><Q><D><A><A><R><K><E><A><L><Q><Q><K><Q>
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA .<BOP>
Q9Y333
P80370
DLK1_HUMAN
Fetal antigen 1
Homo
<M><T><A><T><E><A><L><L><R><V><L><L><L><L><L><A><F><G><H><S><T><Y><G><A><E><C><F><P><A><C><N><P><Q><N><G><F><C><E><D><D><N><V><C><R><C><Q><P><G><W><Q><G><P><L><C><D><Q><C><V><T><S><P><G><C><L><H><G><L><C><G><E><P><G><Q><C><I><C><T><D><G><W><D><G><E><L><C><D><R><D><V><R><A><C><S><S><A><P><C><A><N><N><R><T><C><V><S><L><D><D><G><L><Y><E><C><S><C><A><P><G><Y><S><G><K><D><C><Q><K><K><D><G><P><C><V><I><N><G><S><P><C><Q><H><G><G><T><C><V><D><D><E><G><R><A><S><H><A><S><C><L><C><P><P><G><F><S><G><N><F><C><E><I><V><A><N><S><C><T><P><N><P><C><E><N><D><G><V><C><T><D><I><G><G><D><F><R><C><R><C><P><A><G><F><I><D><K><T><C><S><R><P><V><T><N><C><A><S><S><P><C><Q><N><G><G><T><C><L><Q><H><T><Q><V><S><Y><E><C><L><C><K><P><E><F><T><G><L><T><C><V><K><K><R><A><L><S><P><Q><Q><V><T><R><L><P><S><G><Y><G><L><A><Y><R><L><T><P><G><V><H><E><L><P><V><Q><Q><P><E><H><R><I><L><K><V><S><M><K><E><L><N><K><K><T><P><L><L><T><E><G><Q><A><I><C><F><T><I><L><G><V><L><T><S><L><V><V><L><G><T><V><G><I><V><F><L><N><K><C><E><T><W><V><S><N><L><R><Y><N><H><M><L><R><K><K><K><N><L><L><L><Q><Y><N><S><G><E><D><L><A><V><N><I><I><F><P><E><K><I><D><M><T><T><F><S><K><E><A><G><D><E><E><I>
May have a role in neuroendocrine differentiation.<BOP>
P80370
A0A075B6S5
KV127_HUMAN
Immunoglobulin kappa variable 1-27
Homo
<M><D><M><R><V><P><A><Q><L><L><G><L><L><L><L><W><L><P><D><T><R><C><D><I><Q><M><T><Q><S><P><S><S><L><S><A><S><V><G><D><R><V><T><I><T><C><R><A><S><Q><G><I><S><N><Y><L><A><W><Y><Q><Q><K><P><G><K><V><P><K><L><L><I><Y><A><A><S><T><L><Q><S><G><V><P><S><R><F><S><G><S><G><S><G><T><D><F><T><L><T><I><S><S><L><Q><P><E><D><V><A><T><Y><Y><C><Q><K><Y><N><S><A><P>
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .<BOP>
A0A075B6S5
P08100
OPSD_HUMAN
Opsin-2
Homo
<M><N><G><T><E><G><P><N><F><Y><V><P><F><S><N><A><T><G><V><V><R><S><P><F><E><Y><P><Q><Y><Y><L><A><E><P><W><Q><F><S><M><L><A><A><Y><M><F><L><L><I><V><L><G><F><P><I><N><F><L><T><L><Y><V><T><V><Q><H><K><K><L><R><T><P><L><N><Y><I><L><L><N><L><A><V><A><D><L><F><M><V><L><G><G><F><T><S><T><L><Y><T><S><L><H><G><Y><F><V><F><G><P><T><G><C><N><L><E><G><F><F><A><T><L><G><G><E><I><A><L><W><S><L><V><V><L><A><I><E><R><Y><V><V><V><C><K><P><M><S><N><F><R><F><G><E><N><H><A><I><M><G><V><A><F><T><W><V><M><A><L><A><C><A><A><P><P><L><A><G><W><S><R><Y><I><P><E><G><L><Q><C><S><C><G><I><D><Y><Y><T><L><K><P><E><V><N><N><E><S><F><V><I><Y><M><F><V><V><H><F><T><I><P><M><I><I><I><F><F><C><Y><G><Q><L><V><F><T><V><K><E><A><A><A><Q><Q><Q><E><S><A><T><T><Q><K><A><E><K><E><V><T><R><M><V><I><I><M><V><I><A><F><L><I><C><W><V><P><Y><A><S><V><A><F><Y><I><F><T><H><Q><G><S><N><F><G><P><I><F><M><T><I><P><A><F><F><A><K><S><A><A><I><Y><N><P><V><I><Y><I><M><M><N><K><Q><F><R><N><C><M><L><T><T><I><C><C><G><K><N><P><L><G><D><D><E><A><S><A><T><V><S><K><T><E><T><S><Q><V><A><P><A>
Photoreceptor required for image-forming vision at low light intensity . Required for photoreceptor cell viability after birth . Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins . Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling .<BOP>
P08100
Q8N108
MIER1_HUMAN
Mesoderm induction early response protein 1
Homo
<M><A><E><P><S><V><E><S><S><S><P><G><G><S><A><T><S><D><D><H><E><F><D><P><S><A><D><M><L><V><H><D><F><D><D><E><R><T><L><E><E><E><E><M><M><E><G><E><T><N><F><S><S><E><I><E><D><L><A><R><E><G><D><M><P><I><H><E><L><L><S><L><Y><G><Y><G><S><T><V><R><L><P><E><E><D><E><E><E><E><E><E><E><E><E><G><E><D><D><E><D><A><D><N><D><D><N><S><G><C><S><G><E><N><K><E><E><N><I><K><D><S><S><G><Q><E><D><E><T><Q><S><S><N><D><D><P><S><Q><S><V><A><S><Q><D><A><Q><E><I><I><R><P><R><R><C><K><Y><F><D><T><N><S><E><V><E><E><E><S><E><E><D><E><D><Y><I><P><S><E><D><W><K><K><E><I><M><V><G><S><M><F><Q><A><E><I><P><V><G><I><C><R><Y><K><E><N><E><K><V><Y><E><N><D><D><Q><L><L><W><D><P><E><Y><L><P><E><D><K><V><I><I><F><L><K><D><A><S><R><R><T><G><D><E><K><G><V><E><A><I><P><E><G><S><H><I><K><D><N><E><Q><A><L><Y><E><L><V><K><C><N><F><D><T><E><E><A><L><R><R><L><R><F><N><V><K><A><A><R><E><E><L><S><V><W><T><E><E><E><C><R><N><F><E><Q><G><L><K><A><Y><G><K><D><F><H><L><I><Q><A><N><K><V><R><T><R><S><V><G><E><C><V><A><F><Y><Y><M><W><K><K><S><E><R><Y><D><F><F><A><Q><Q><T><R><F><G><K><K><K><Y><N><L><H><P><G><V><T><D><Y><M><D><R><L><L><D><E><S><E><S><A><A><S><S><R><A><P><S><P><P><P><T><A><S><N><S><S><N><S><Q><S><E><K><E><D><G><T><V><S><T><A><N><Q><N><G><V><S><S><N><G><P><G><E><I><L><N><K><E><E><V><K><V><E><G><L><H><I><N><G><P><T><G><G><N><K><K><P><L><H><A><D><M><D><T><N><G><Y><E><T><D><N><L><T><T><D><P><K><L><A><H><M><T><A><R><N><E><N><D><F><D><E><K><S><E><R><P><A><K><R><R><R><V><N><S><N><G><K><E><S><P><G><S><S><E><F><F><Q><E><A><V><S><H><G><K><F><E><E><L><E><N><T><D><D>
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.<BOP>
Q8N108
Q9BTE6
AASD1_HUMAN
Alanyl-tRNA synthetase domain-containing protein 1
Homo
<M><A><F><W><C><Q><R><D><S><Y><A><R><E><F><T><T><T><V><V><S><C><C><P><A><E><L><Q><T><E><G><S><N><G><K><K><E><V><L><S><G><F><Q><V><V><L><E><D><T><V><L><F><P><E><G><G><G><Q><P><D><D><R><G><T><I><N><D><I><S><V><L><R><V><T><R><R><G><E><Q><A><D><H><F><T><Q><T><P><L><D><P><G><S><Q><V><L><V><R><V><D><W><E><R><R><F><D><H><M><Q><Q><H><S><G><Q><H><L><I><T><A><V><A><D><H><L><F><K><L><K><T><T><S><W><E><L><G><R><F><R><S><A><I><E><L><D><T><P><S><M><T><A><E><Q><V><A><A><I><E><Q><S><V><N><E><K><I><R><D><R><L><P><V><N><V><R><E><L><S><L><D><D><P><E><V><E><Q><V><S><G><R><G><L><P><D><D><H><A><G><P><I><R><V><V><N><I><E><G><V><D><S><N><M><C><C><G><T><H><V><S><N><L><S><D><L><Q><V><I><K><I><L><G><T><E><K><G><K><K><N><R><T><N><L><I><F><L><S><G><N><R><V><L><K><W><M><E><R><S><H><G><T><E><K><A><L><T><A><L><L><K><C><G><A><E><D><H><V><E><A><V><K><K><L><Q><N><S><T><K><I><L><Q><K><N><N><L><N><L><L><R><D><L><A><V><H><I><A><H><S><L><R><N><S><P><D><W><G><G><V><V><I><L><H><R><K><E><G><D><S><E><F><M><N><I><I><A><N><E><I><G><S><E><E><T><L><L><F><L><T><V><G><D><E><K><G><G><G><L><F><L><L><A><G><P><P><A><S><V><E><T><L><G><P><R><V><A><E><V><L><E><G><K><G><A><G><K><K><G><R><F><Q><G><K><A><T><K><M><S><R><R><M><E><A><Q><A><L><L><Q><D><Y><I><S><T><Q><S><A><K><E>
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).<BOP>
Q9BTE6
Q96T68
SETB2_HUMAN
SET domain bifurcated 2
Homo
<M><G><E><K><N><G><D><A><K><T><F><W><M><E><L><E><D><D><G><K><V><D><F><I><F><E><Q><V><Q><N><V><L><Q><S><L><K><Q><K><I><K><D><G><S><A><T><N><K><E><Y><I><Q><A><M><I><L><V><N><E><A><T><I><I><N><S><S><T><S><I><K><G><A><S><Q><K><E><V><N><A><Q><S><S><D><P><M><P><V><T><Q><K><E><Q><E><N><K><S><N><A><F><P><S><T><S><C><E><N><S><F><P><E><D><C><T><F><L><T><T><E><N><K><E><I><L><S><L><E><D><K><V><V><D><F><R><E><K><D><S><S><S><N><L><S><Y><Q><S><H><D><C><S><G><A><C><L><M><K><M><P><L><N><L><K><G><E><N><P><L><Q><L><P><I><K><C><H><F><Q><R><R><H><A><K><T><N><S><H><S><S><A><L><H><V><S><Y><K><T><P><C><G><R><S><L><R><N><V><E><E><V><F><R><Y><L><L><E><T><E><C><N><F><L><F><T><D><N><F><S><F><N><T><Y><V><Q><L><A><R><N><Y><P><K><Q><K><E><V><V><S><D><V><D><I><S><N><G><V><E><S><V><P><I><S><F><C><N><E><I><D><S><R><K><L><P><Q><F><K><Y><R><K><T><V><W><P><R><A><Y><N><L><T><N><F><S><S><M><F><T><D><S><C><D><C><S><E><G><C><I><D><I><T><K><C><A><C><L><Q><L><T><A><R><N><A><K><T><S><P><L><S><S><D><K><I><T><T><G><Y><K><Y><K><R><L><Q><R><Q><I><P><T><G><I><Y><E><C><S><L><L><C><K><C><N><R><Q><L><C><Q><N><R><V><V><Q><H><G><P><Q><V><R><L><Q><V><F><K><T><E><Q><K><G><W><G><V><R><C><L><D><D><I><D><R><G><T><F><V><C><I><Y><S><G><R><L><L><S><R><A><N><T><E><K><S><Y><G><I><D><E><N><G><R><D><E><N><T><M><K><N><I><F><S><K><K><R><K><L><E><V><A><C><S><D><C><E><V><E><V><L><P><L><G><L><E><T><H><P><R><T><A><K><T><E><K><C><P><P><K><F><S><N><N><P><K><E><L><T><V><E><T><K><Y><D><N><I><S><R><I><Q><Y><H><S><V><I><R><D><P><E><S><K><T><A><I><F><Q><H><N><G><K><K><M><E><F><V><S><S><E><S><V><T><P><E><D><N><D><G><F><K><P><P><R><E><H><L><N><S><K><T><K><G><A><Q><K><D><S><S><S><N><H><V><D><E><F><E><D><N><L><L><I><E><S><D><V><I><D><I><T><K><Y><R><E><E><T><P><P><R><S><R><C><N><Q><A><T><T><L><D><N><Q><N><I><K><K><A><I><E><V><Q><I><Q><K><P><Q><E><G><R><S><T><A><C><Q><R><Q><Q><V><F><C><D><E><E><L><L><S><E><T><K><N><T><S><S><D><S><L><T><K><F><N><K><G><N><V><F><L><L><D><A><T><K><E><G><N><V><G><R><F><L><N><H><S><C><C><P><N><L><L><V><Q><N><V><F><V><E><T><H><N><R><N><F><P><L><V><A><F><F><T><N><R><Y><V><K><A><R><T><E><L><T><W><D><Y><G><Y><E><A><G><T><V><P><E><K><E><I><F><C><Q><C><G><V><N><K><C><R><K><K><I><L>
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.<BOP>
Q96T68
Q92925
SMRD2_HUMAN
BRG1-associated factor 60B
Homo
<M><S><G><R><G><A><G><G><F><P><L><P><P><L><S><P><G><G><G><A><V><A><A><A><L><G><A><P><P><P><P><A><G><P><G><M><L><P><G><P><A><L><R><G><P><G><P><A><G><G><V><G><G><P><G><A><A><A><F><R><P><M><G><P><A><G><P><A><A><Q><Y><Q><R><P><G><M><S><P><G><N><R><M><P><M><A><G><L><Q><V><G><P><P><A><G><S><P><F><G><A><A><A><P><L><R><P><G><M><P><P><T><M><M><D><P><F><R><K><R><L><L><V><P><Q><A><Q><P><P><M><P><A><Q><R><R><G><L><K><R><R><K><M><A><D><K><V><L><P><Q><R><I><R><E><L><V><P><E><S><Q><A><Y><M><D><L><L><A><F><E><R><K><L><D><Q><T><I><A><R><K><R><M><E><I><Q><E><A><I><K><K><P><L><T><Q><K><R><K><L><R><I><Y><I><S><N><T><F><S><P><S><K><A><E><G><D><S><A><G><T><A><G><T><P><G><G><T><P><A><G><D><K><V><A><S><W><E><L><R><V><E><G><K><L><L><D><D><P><S><K><Q><K><R><K><F><S><S><F><F><K><S><L><V><I><E><L><D><K><E><L><Y><G><P><D><N><H><L><V><E><W><H><R><M><P><T><T><Q><E><T><D><G><F><Q><V><K><R><P><G><D><L><N><V><K><C><T><L><L><L><M><L><D><H><Q><P><P><Q><Y><K><L><D><P><R><L><A><R><L><L><G><V><H><T><Q><T><R><A><A><I><M><Q><A><L><W><L><Y><I><K><H><N><Q><L><Q><D><G><H><E><R><E><Y><I><N><C><N><R><Y><F><R><Q><I><F><S><C><G><R><L><R><F><S><E><I><P><M><K><L><A><G><L><L><Q><H><P><D><P><I><V><I><N><H><V><I><S><V><D><P><N><D><Q><K><K><T><A><C><Y><D><I><D><V><E><V><D><D><P><L><K><A><Q><M><S><N><F><L><A><S><T><T><N><Q><Q><E><I><A><S><L><D><V><K><I><H><E><T><I><E><S><I><N><Q><L><K><T><Q><R><D><F><M><L><S><F><S><T><D><P><Q><D><F><I><Q><E><W><L><R><S><Q><R><R><D><L><K><I><I><T><D><V><I><G><N><P><E><E><E><R><R><A><A><F><Y><H><Q><P><W><A><Q><E><A><V><G><R><H><I><F><A><K><V><Q><Q><R><R><Q><E><L><E><Q><V><L><G><I><R><L><T>
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner . Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation .<BOP>
Q92925
P21757
MSRE_HUMAN
Scavenger receptor class A member 1
Homo
<M><E><Q><W><D><H><F><H><N><Q><Q><E><D><T><D><S><C><S><E><S><V><K><F><D><A><R><S><M><T><A><L><L><P><P><N><P><K><N><S><P><S><L><Q><E><K><L><K><S><F><K><A><A><L><I><A><L><Y><L><L><V><F><A><V><L><I><P><L><I><G><I><V><A><A><Q><L><L><K><W><E><T><K><N><C><S><V><S><S><T><N><A><N><D><I><T><Q><S><L><T><G><K><G><N><D><S><E><E><E><M><R><F><Q><E><V><F><M><E><H><M><S><N><M><E><K><R><I><Q><H><I><L><D><M><E><A><N><L><M><D><T><E><H><F><Q><N><F><S><M><T><T><D><Q><R><F><N><D><I><L><L><Q><L><S><T><L><F><S><S><V><Q><G><H><G><N><A><I><D><E><I><S><K><S><L><I><S><L><N><T><T><L><L><D><L><Q><L><N><I><E><N><L><N><G><K><I><Q><E><N><T><F><K><Q><Q><E><E><I><S><K><L><E><E><R><V><Y><N><V><S><A><E><I><M><A><M><K><E><E><Q><V><H><L><E><Q><E><I><K><G><E><V><K><V><L><N><N><I><T><N><D><L><R><L><K><D><W><E><H><S><Q><T><L><R><N><I><T><L><I><Q><G><P><P><G><P><P><G><E><K><G><D><R><G><P><T><G><E><S><G><P><R><G><F><P><G><P><I><G><P><P><G><L><K><G><D><R><G><A><I><G><F><P><G><S><R><G><L><P><G><Y><A><G><R><P><G><N><S><G><P><K><G><Q><K><G><E><K><G><S><G><N><T><L><T><P><F><T><K><V><R><L><V><G><G><S><G><P><H><E><G><R><V><E><I><L><H><S><G><Q><W><G><T><I><C><D><D><R><W><E><V><R><V><G><Q><V><V><C><R><S><L><G><Y><P><G><V><Q><A><V><H><K><A><A><H><F><G><Q><G><T><G><P><I><W><L><N><E><V><F><C><F><G><R><E><S><S><I><E><E><C><K><I><R><Q><W><G><T><R><A><C><S><H><S><E><D><A><G><V><T><C><T><L>
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) . Isoform III does not internalize acetylated LDL .<BOP>
P21757
A6NDE4
RBY1B_HUMAN
RNA-binding motif protein, Y chromosome, family 1 member B
Homo
<M><V><E><A><D><H><P><G><K><L><F><I><G><G><L><N><R><E><T><N><E><K><M><L><K><A><V><F><G><K><H><G><P><I><S><E><V><L><L><I><K><D><R><T><S><K><S><R><G><F><A><F><I><T><F><E><N><P><A><D><A><K><N><A><A><K><D><M><N><G><K><S><L><H><G><K><A><I><K><V><E><Q><A><K><K><P><S><F><Q><S><G><G><R><R><R><P><P><A><S><S><R><N><R><S><P><S><G><S><L><R><S><A><R><G><S><R><G><G><T><R><G><W><L><P><S><Q><E><G><H><L><D><D><G><G><Y><T><P><D><L><K><M><S><Y><S><R><G><L><I><P><V><K><R><G><P><S><S><R><S><G><G><P><P><P><K><K><S><A><P><S><A><V><A><R><S><N><S><W><M><G><S><Q><G><P><M><S><Q><R><R><E><N><Y><G><V><P><P><R><R><A><T><I><S><S><W><R><N><D><R><M><S><T><R><H><D><G><Y><A><T><N><D><G><N><H><P><S><C><Q><E><T><R><D><Y><A><P><P><S><R><G><Y><A><Y><R><D><N><G><H><S><N><R><D><E><H><S><S><R><G><Y><R><N><H><R><S><S><R><E><T><R><D><Y><A><P><P><S><R><G><H><A><Y><R><D><Y><G><H><S><R><R><D><E><S><Y><S><R><G><Y><R><N><R><R><S><S><R><E><T><R><E><Y><A><P><P><S><R><G><H><G><Y><R><D><Y><G><H><S><R><R><H><E><S><Y><S><R><G><Y><R><N><H><P><S><S><R><E><T><R><D><Y><A><P><P><H><R><D><Y><A><Y><R><D><Y><G><H><S><S><W><D><E><H><S><S><R><G><Y><S><Y><H><D><G><Y><G><E><A><L><G><R><D><H><S><E><H><L><S><G><S><S><Y><R><D><A><L><Q><R><Y><G><T><S><H><G><A><P><P><A><R><G><P><R><M><S><Y><G><G><S><T><C><H><A><Y><S><N><T><R><D><R><Y><G><R><S><W><E><S><Y><S><S><C><G><D><F><H><Y><C><D><R><E><H><V><C><R><K><D><Q><R><N><P><P><S><L><G><R><V><L><P><D><P><R><E><A><Y><G><S><S><S><Y><V><A><S><I><V><D><G><G><E><S><R><S><E><K><G><D><S><S><R><Y>
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.<BOP>
A6NDE4
Q9UK97
FBX9_HUMAN
Renal carcinoma antigen NY-REN-57
Homo
<M><P><D><I><I><W><V><F><P><P><Q><A><E><A><E><E><D><C><H><S><D><T><V><R><A><D><D><D><E><E><N><E><S><P><A><E><T><D><L><Q><A><Q><L><Q><M><F><R><A><Q><W><M><F><E><L><A><P><G><V><S><S><S><N><L><E><N><R><P><C><R><A><A><R><G><S><L><Q><K><T><S><A><D><T><K><G><K><Q><E><Q><A><K><E><E><K><A><R><E><L><F><L><K><A><V><E><E><E><Q><N><G><A><L><Y><E><A><I><K><F><Y><R><R><A><M><Q><L><V><P><D><I><E><F><K><I><T><Y><T><R><S><P><D><G><D><G><V><G><N><S><Y><I><E><D><N><D><D><D><S><K><M><A><D><L><L><S><Y><F><Q><Q><Q><L><T><F><Q><E><S><V><L><K><L><C><Q><P><E><L><E><S><S><Q><I><H><I><S><V><L><P><M><E><V><L><M><Y><I><F><R><W><V><V><S><S><D><L><D><L><R><S><L><E><Q><L><S><L><V><C><R><G><F><Y><I><C><A><R><D><P><E><I><W><R><L><A><C><L><K><V><W><G><R><S><C><I><K><L><V><P><Y><T><S><W><R><E><M><F><L><E><R><P><R><V><R><F><D><G><V><Y><I><S><K><T><T><Y><I><R><Q><G><E><Q><S><L><D><G><F><Y><R><A><W><H><Q><V><E><Y><Y><R><Y><I><R><F><F><P><D><G><H><V><M><M><L><T><T><P><E><E><P><Q><S><I><V><P><R><L><R><T><R><N><T><R><T><D><A><I><L><L><G><H><Y><R><L><S><Q><D><T><D><N><Q><T><K><V><F><A><V><I><T><K><K><K><E><E><K><P><L><D><Y><K><Y><R><Y><F><R><R><V><P><V><Q><E><A><D><Q><S><F><H><V><G><L><Q><L><C><S><S><G><H><Q><R><F><N><K><L><I><W><I><H><H><S><C><H><I><T><Y><K><S><T><G><E><T><A><V><S><A><F><E><I><D><K><M><Y><T><P><L><F><F><A><R><V><R><S><Y><T><A><F><S><E><R><P><L>
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.<BOP>
Q9UK97
Q9BUN5
CC28B_HUMAN
Coiled-coil domain-containing protein 28B
Homo
<M><D><D><K><K><K><K><R><S><P><K><P><C><L><A><Q><P><A><Q><A><P><G><T><L><R><R><V><P><V><P><T><S><H><S><G><S><L><A><L><G><L><P><H><L><P><S><P><K><Q><R><A><K><F><K><R><V><G><K><E><K><C><R><P><V><L><A><G><G><G><S><G><S><A><G><T><P><L><Q><H><S><F><L><T><E><V><T><D><V><Y><E><M><E><G><G><L><L><N><L><L><N><D><F><H><S><G><R><L><Q><A><F><G><K><E><C><S><F><E><Q><L><E><H><V><R><E><M><Q><E><K><L><A><R><L><H><F><S><L><D><V><C><G><E><E><E><D><D><E><E><E><E><D><G><V><T><E><G><L><P><E><E><Q><K><K><T><M><A><D><R><N><L><D><Q><L><L><S><N><L><E><D><L><S><N><S><I><Q><K><L><H><L><A><E><N><A><E><P><E><E><Q><S><A><A>
Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.<BOP>
Q9BUN5
Q10587
TEF_HUMAN
Thyrotroph embryonic factor
Homo
<M><S><D><A><G><G><G><K><K><P><P><V><D><P><Q><A><G><P><G><P><G><P><G><R><A><A><G><E><R><G><L><S><G><S><F><P><L><V><L><K><K><L><M><E><N><P><P><R><E><A><R><L><D><K><E><K><G><K><E><K><L><E><E><D><E><A><A><A><A><S><T><M><A><V><S><A><S><L><M><P><P><I><W><D><K><T><I><P><Y><D><G><E><S><F><H><L><E><Y><M><D><L><D><E><F><L><L><E><N><G><I><P><A><S><P><T><H><L><A><H><N><L><L><L><P><V><A><E><L><E><G><K><E><S><A><S><S><S><T><A><S><P><P><S><S><S><T><A><I><F><Q><P><S><E><T><V><S><S><T><E><S><S><L><E><K><E><R><E><T><P><S><P><I><D><P><N><C><V><E><V><D><V><N><F><N><P><D><P><A><D><L><V><L><S><S><V><P><G><G><E><L><F><N><P><R><K><H><K><F><A><E><E><D><L><K><P><Q><P><M><I><K><K><A><K><K><V><F><V><P><D><E><Q><K><D><E><K><Y><W><T><R><R><K><K><N><N><V><A><A><K><R><S><R><D><A><R><R><L><K><E><N><Q><I><T><I><R><A><A><F><L><E><K><E><N><T><A><L><R><T><E><V><A><E><L><R><K><E><V><G><K><C><K><T><I><V><S><K><Y><E><T><K><Y><G><P><L>
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.<BOP>
Q10587
O14957
QCR10_HUMAN
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Homo
<M><V><T><R><F><L><G><P><R><Y><R><E><L><V><K><N><W><V><P><T><A><Y><T><W><G><A><V><G><A><V><G><L><V><W><A><T><D><W><R><L><I><L><D><W><V><P><Y><I><N><G><K><F><K><K><D><N>
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability.<BOP>
O14957
Q969J5
I22R2_HUMAN
ZcytoR16
Homo
<M><M><P><K><H><C><F><L><G><F><L><I><S><F><F><L><T><G><V><A><G><T><Q><S><T><H><E><S><L><K><P><Q><R><V><Q><F><Q><S><R><N><F><H><N><I><L><Q><W><Q><P><G><R><A><L><T><G><N><S><S><V><Y><F><V><Q><Y><K><I><M><F><S><C><S><M><K><S><S><H><Q><K><P><S><G><C><W><Q><H><I><S><C><N><F><P><G><C><R><T><L><A><K><Y><G><Q><R><Q><W><K><N><K><E><D><C><W><G><T><Q><E><L><S><C><D><L><T><S><E><T><S><D><I><Q><E><P><Y><Y><G><R><V><R><A><A><S><A><G><S><Y><S><E><W><S><M><T><P><R><F><T><P><W><W><E><T><K><I><D><P><P><V><M><N><I><T><Q><V><N><G><S><L><L><V><I><L><H><A><P><N><L><P><Y><R><Y><Q><K><E><K><N><V><S><I><E><D><Y><Y><E><L><L><Y><R><V><F><I><I><N><N><S><L><E><K><E><Q><K><V><Y><E><G><A><H><R><A><V><E><I><E><A><L><T><P><H><S><S><Y><C><V><V><A><E><I><Y><Q><P><M><L><D><R><R><S><Q><R><S><E><E><R><C><V><E><I><P>
Isoform 1 may play a role in establishing and maintaining successful pregnancy.<BOP>
Q969J5
Q9NR11
ZN302_HUMAN
Zinc finger protein 327
Homo
<M><S><Q><V><T><F><S><D><V><A><I><D><F><S><H><E><E><W><A><C><L><D><S><A><Q><R><D><L><Y><K><D><V><M><V><Q><N><Y><E><N><L><V><S><V><G><L><S><V><T><K><P><Y><V><I><M><L><L><E><D><G><K><E><P><W><M><M><E><K><K><L><S><K><A><Y><P><F><P><L><S><H><S><V><P><A><S><V><N><F><G><F><S><A><L><F><E><H><C><S><E><V><T><E><I><F><E><L><S><E><L><C><V><F><W><V><L><H><F><L><S><N><S><P><N><S><T><V><E><A><F><S><R><S><K><K><K><K><K><K><K><K><K><R><Q><C><F><A><F><L><I><Y><F><R><L><G><I><K><M><G><K><Q><G><I><I><N><K><E><G><Y><L><Y><E><D><S><P><Q><P><V><T><M><E><K><V><V><K><Q><S><Y><E><F><S><N><S><N><K><N><L><E><Y><T><E><C><D><T><F><R><S><T><F><H><S><K><S><T><L><S><E><P><Q><N><N><S><A><E><G><N><S><H><K><Y><D><I><L><K><K><N><L><S><K><K><S><V><I><K><S><E><R><I><N><G><G><K><K><L><L><N><S><N><K><S><G><A><A><F><N><Q><S><K><S><L><T><L><P><Q><T><C><N><R><E><K><I><Y><T><C><S><E><C><G><K><A><F><G><K><Q><S><I><L><S><R><H><W><R><I><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><T><F><S><H><G><S><S><L><T><R><H><Q><I><S><H><S><G><E><K><P><Y><K><C><I><E><C><G><K><A><F><S><H><G><S><S><L><T><N><H><Q><S><T><H><T><G><E><K><P><Y><E><C><M><N><C><G><K><S><F><S><R><V><S><L><L><I><Q><H><L><R><I><H><T><Q><E><K><R><Y><E><C><R><I><C><G><K><A><F><I><H><S><S><S><L><I><H><H><Q><K><S><H><T><G><E><K><P><Y><E><C><R><E><C><G><K><A><F><C><C><S><S><H><L><T><Q><H><Q><R><I><H><S><M><K><K><K><Y><E><C><N><K><C><L><K><V><F><S><S><F><S><F><L><V><Q><H><Q><S><I><H><T><E><E><K><P><F><E><V>
May be involved in transcriptional regulation.<BOP>
Q9NR11
P01850
TRBC1_HUMAN
T cell receptor beta constant 1
Homo
<D><L><N><K><V><F><P><P><E><V><A><V><F><E><P><S><E><A><E><I><S><H><T><Q><K><A><T><L><V><C><L><A><T><G><F><F><P><D><H><V><E><L><S><W><W><V><N><G><K><E><V><H><S><G><V><S><T><D><P><Q><P><L><K><E><Q><P><A><L><N><D><S><R><Y><C><L><S><S><R><L><R><V><S><A><T><F><W><Q><N><P><R><N><H><F><R><C><Q><V><Q><F><Y><G><L><S><E><N><D><E><W><T><Q><D><R><A><K><P><V><T><Q><I><V><S><A><E><A><W><G><R><A><D><C><G><F><T><S><V><S><Y><Q><Q><G><V><L><S><A><T><I><L><Y><E><I><L><L><G><K><A><T><L><Y><A><V><L><V><S><A><L><V><L><M><A><M><V><K><R><K><D><F>
Constant region of T cell receptor (TR) beta chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrath
P01850
Q15818
NPTX1_HUMAN
Neuronal pentraxin I
Homo
<M><P><A><G><R><A><A><R><T><C><A><L><L><A><L><C><L><L><G><A><G><A><Q><D><F><G><P><T><R><F><I><C><T><S><V><P><V><D><A><D><M><C><A><A><S><V><A><A><G><G><A><E><E><L><R><S><S><V><L><Q><L><R><E><T><V><L><Q><Q><K><E><T><I><L><S><Q><K><E><T><I><R><E><L><T><A><K><L><G><R><C><E><S><Q><S><T><L><D><P><G><A><G><E><A><R><A><G><G><G><R><K><Q><P><G><S><G><K><N><T><M><G><D><L><S><R><T><P><A><A><E><T><L><S><Q><L><G><Q><T><L><Q><S><L><K><T><R><L><E><N><L><E><Q><Y><S><R><L><N><S><S><S><Q><T><N><S><L><K><D><L><L><Q><S><K><I><D><E><L><E><R><Q><V><L><S><R><V><N><T><L><E><E><G><K><G><G><P><R><N><D><T><E><E><R><V><K><I><E><T><A><L><T><S><L><H><Q><R><I><S><E><L><E><K><G><Q><K><D><N><R><P><G><D><K><F><Q><L><T><F><P><L><R><T><N><Y><M><Y><A><K><V><K><K><S><L><P><E><M><Y><A><F><T><V><C><M><W><L><K><S><S><A><T><P><G><V><G><T><P><F><S><Y><A><V><P><G><Q><A><N><E><L><V><L><I><E><W><G><N><N><P><M><E><I><L><I><N><D><K><V><A><K><L><P><F><V><I><N><D><G><K><W><H><H><I><C><V><T><W><T><T><R><D><G><V><W><E><A><Y><Q><D><G><T><Q><G><G><S><G><E><N><L><A><P><Y><H><P><I><K><P><Q><G><V><L><V><L><G><Q><E><Q><D><T><L><G><G><G><F><D><A><T><Q><A><F><V><G><E><L><A><H><F><N><I><W><D><R><K><L><T><P><G><E><V><Y><N><L><A><T><C><S><T><K><A><L><S><G><N><V><I><A><W><A><E><S><H><I><E><I><Y><G><G><A><T><K><W><T><F><E><A><C><R><Q><I><N>
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.<BOP>
Q15818
Q04844
ACHE_HUMAN
Acetylcholine receptor subunit epsilon
Homo
<M><A><R><A><P><L><G><V><L><L><L><L><G><L><L><G><R><G><V><G><K><N><E><E><L><R><L><Y><H><H><L><F><N><N><Y><D><P><G><S><R><P><V><R><E><P><E><D><T><V><T><I><S><L><K><V><T><L><T><N><L><I><S><L><N><E><K><E><E><T><L><T><T><S><V><W><I><G><I><D><W><Q><D><Y><R><L><N><Y><S><K><D><D><F><G><G><I><E><T><L><R><V><P><S><E><L><V><W><L><P><E><I><V><L><E><N><N><I><D><G><Q><F><G><V><A><Y><D><A><N><V><L><V><Y><E><G><G><S><V><T><W><L><P><P><A><I><Y><R><S><V><C><A><V><E><V><T><Y><F><P><F><D><W><Q><N><C><S><L><I><F><R><S><Q><T><Y><N><A><E><E><V><E><F><T><F><A><V><D><N><D><G><K><T><I><N><K><I><D><I><D><T><E><A><Y><T><E><N><G><E><W><A><I><D><F><C><P><G><V><I><R><R><H><H><G><G><A><T><D><G><P><G><E><T><D><V><I><Y><S><L><I><I><R><R><K><P><L><F><Y><V><I><N><I><I><V><P><C><V><L><I><S><G><L><V><L><L><A><Y><F><L><P><A><Q><A><G><G><Q><K><C><T><V><S><I><N><V><L><L><A><Q><T><V><F><L><F><L><I><A><Q><K><I><P><E><T><S><L><S><V><P><L><L><G><R><F><L><I><F><V><M><V><V><A><T><L><I><V><M><N><C><V><I><V><L><N><V><S><Q><R><T><P><T><T><H><A><M><S><P><R><L><R><H><V><L><L><E><L><L><P><R><L><L><G><S><P><P><P><P><E><A><P><R><A><A><S><P><P><R><R><A><S><S><V><G><L><L><L><R><A><E><E><L><I><L><K><K><P><R><S><E><L><V><F><E><G><Q><R><H><R><Q><G><T><W><T><A><A><F><C><Q><S><L><G><A><A><A><P><E><V><R><C><C><V><D><A><V><N><F><V><A><E><S><T><R><D><Q><E><A><T><G><E><E><V><S><D><W><V><R><M><G><N><A><L><D><N><I><C><F><W><A><A><L><V><L><F><S><V><G><S><S><L><I><F><L><G><A><Y><F><N><R><V><P><D><L><P><Y><A><P><C><I><Q><P>
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.<BOP>
Q04844
P46527
CDN1B_HUMAN
p27Kip1
Homo
<M><S><N><V><R><V><S><N><G><S><P><S><L><E><R><M><D><A><R><Q><A><E><H><P><K><P><S><A><C><R><N><L><F><G><P><V><D><H><E><E><L><T><R><D><L><E><K><H><C><R><D><M><E><E><A><S><Q><R><K><W><N><F><D><F><Q><N><H><K><P><L><E><G><K><Y><E><W><Q><E><V><E><K><G><S><L><P><E><F><Y><Y><R><P><P><R><P><P><K><G><A><C><K><V><P><A><Q><E><S><Q><D><V><S><G><S><R><P><A><A><P><L><I><G><A><P><A><N><S><E><D><T><H><L><V><D><P><K><T><D><P><S><D><S><Q><T><G><L><A><E><Q><C><A><G><I><R><K><R><P><A><T><D><D><S><S><T><Q><N><K><R><A><N><R><T><E><E><N><V><S><D><G><S><P><N><A><G><S><V><E><Q><T><P><K><K><P><G><L><R><R><R><Q><T>
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.<BOP>
P46527
Q6P4I2
WDR73_HUMAN
WD repeat-containing protein 73
Homo
<M><D><P><G><D><D><W><L><V><E><S><L><R><L><Y><Q><D><F><Y><A><F><D><L><S><G><A><T><R><V><L><E><W><I><D><D><K><G><V><F><V><A><G><Y><E><S><L><K><K><N><E><I><L><H><L><K><L><P><L><R><L><S><V><K><E><N><K><G><L><F><P><E><R><D><F><K><V><R><H><G><G><F><S><D><R><S><I><F><D><L><K><H><V><P><H><T><R><L><L><V><T><S><G><L><P><G><C><Y><L><Q><V><W><Q><V><A><E><D><S><D><V><I><K><A><V><S><T><I><A><V><H><E><K><E><E><S><L><W><P><R><V><A><V><F><S><T><L><A><P><G><V><L><H><G><A><R><L><R><S><L><Q><V><V><D><L><E><S><R><K><T><T><Y><T><S><D><V><S><D><S><E><E><L><S><S><L><Q><V><L><D><A><D><T><F><A><F><C><C><A><S><G><R><L><G><L><V><D><T><R><Q><K><W><A><P><L><E><N><R><S><P><G><P><G><S><G><G><E><R><W><C><A><E><V><G><S><W><G><Q><G><P><G><P><S><I><A><S><L><G><S><D><G><R><L><C><L><L><D><P><R><D><L><C><H><P><V><S><S><V><Q><C><P><V><S><V><P><S><P><D><P><E><L><L><R><V><T><W><A><P><G><L><K><N><C><L><A><I><S><G><F><D><G><T><V><Q><V><Y><D><A><T><S><W><D><G><T><R><S><Q><D><G><T><R><S><Q><V><E><P><L><F><T><H><R><G><H><I><F><L><D><G><N><G><M><D><P><A><P><L><V><T><T><H><T><W><H><P><C><R><P><R><T><L><L><S><A><T><N><D><A><S><L><H><V><W><D><W><V><D><L><C><A><P><R>
May play a role in the regulation of microtubule organization and dynamics .<BOP>
Q6P4I2
Q92575
UBXN4_HUMAN
UBX domain-containing protein 2
Homo
<M><L><W><F><Q><G><A><I><P><A><A><I><A><T><A><K><R><S><G><A><V><F><V><V><F><V><A><G><D><D><E><Q><S><T><Q><M><A><A><S><W><E><D><D><K><V><T><E><A><S><S><N><S><F><V><A><I><K><I><D><T><K><S><E><A><C><L><Q><F><S><Q><I><Y><P><V><V><C><V><P><S><S><F><F><I><G><D><S><G><I><P><L><E><V><I><A><G><S><V><S><A><D><E><L><V><T><R><I><H><K><V><R><Q><M><H><L><L><K><S><E><T><S><V><A><N><G><S><Q><S><E><S><S><V><S><T><P><S><A><S><F><E><P><N><N><T><C><E><N><S><Q><S><R><N><A><E><L><C><E><I><P><P><T><S><D><T><K><S><D><T><A><T><G><G><E><S><A><G><H><A><T><S><S><Q><E><P><S><G><C><S><D><Q><R><P><A><E><D><L><N><I><R><V><E><R><L><T><K><K><L><E><E><R><R><E><E><K><R><K><E><E><E><Q><R><E><I><K><K><E><I><E><R><R><K><T><G><K><E><M><L><D><Y><K><R><K><Q><E><E><E><L><T><K><R><M><L><E><E><R><N><R><E><K><A><E><D><R><A><A><R><E><R><I><K><Q><Q><I><A><L><D><R><A><E><R><A><A><R><F><A><K><T><K><E><E><V><E><A><A><K><A><A><A><L><L><A><K><Q><A><E><M><E><V><K><R><E><S><Y><A><R><E><R><S><T><V><A><R><I><Q><F><R><L><P><D><G><S><S><F><T><N><Q><F><P><S><D><A><P><L><E><E><A><R><Q><F><A><A><Q><T><V><G><N><T><Y><G><N><F><S><L><A><T><M><F><P><R><R><E><F><T><K><E><D><Y><K><K><K><L><L><D><L><E><L><A><P><S><A><S><V><V><L><L><P><A><G><R><P><T><A><S><I><V><H><S><S><S><G><D><I><W><T><L><L><G><T><V><L><Y><P><F><L><A><I><W><R><L><I><S><N><F><L><F><S><N><P><P><P><T><Q><T><S><V><R><V><T><S><S><E><P><P><N><P><A><S><S><S><K><S><E><K><R><E><P><V><R><K><R><V><L><E><K><R><G><D><D><F><K><K><E><G><K><I><Y><R><L><R><T><Q><D><D><G><E><D><E><N><N><T><W><N><G><N><S><T><Q><Q><M>
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD .<BOP>
Q92575
Q96LB3
IFT74_HUMAN
Coiled-coil domain-containing protein 2
Homo
<M><A><S><N><H><K><S><S><A><A><R><P><V><S><R><G><G><V><G><L><T><G><R><P><P><S><G><I><R><P><L><S><G><N><I><R><V><A><T><A><M><P><P><G><T><A><R><P><G><S><R><G><C><P><I><G><T><G><G><V><L><S><S><Q><I><K><V><A><H><R><P><V><T><Q><Q><G><L><T><G><M><K><T><G><T><K><G><P><Q><R><Q><I><L><D><K><S><Y><Y><L><G><L><L><R><S><K><I><S><E><L><T><T><E><V><N><K><L><Q><K><G><I><E><M><Y><N><Q><E><N><S><V><Y><L><S><Y><E><K><R><A><E><T><L><A><V><E><I><K><E><L><Q><G><Q><L><A><D><Y><N><M><L><V><D><K><L><N><T><N><T><E><M><E><E><V><M><N><D><Y><N><M><L><K><A><Q><N><D><R><E><T><Q><S><L><D><V><I><F><T><E><R><Q><A><K><E><K><Q><I><R><S><V><E><E><E><I><E><Q><E><K><Q><A><T><D><D><I><I><K><N><M><S><F><E><N><Q><V><K><Y><L><E><M><K><T><T><N><E><K><L><L><Q><E><L><D><T><L><Q><Q><Q><L><D><S><Q><N><M><K><K><E><S><L><E><A><E><I><A><H><S><Q><V><K><Q><E><A><V><L><L><H><E><K><L><Y><E><L><E><S><H><R><D><Q><M><I><A><E><D><K><S><I><G><S><P><M><E><E><R><E><K><L><L><K><Q><I><K><D><D><N><Q><E><I><A><S><M><E><R><Q><L><T><D><T><K><E><K><I><N><Q><F><I><E><E><I><R><Q><L><D><M><D><L><E><E><H><Q><G><E><M><N><Q><K><Y><K><E><L><K><K><R><E><E><H><M><D><T><F><I><E><T><F><E><E><T><K><N><Q><E><L><K><R><K><A><Q><I><E><A><N><I><V><A><L><L><E><H><C><S><R><N><I><N><R><I><E><Q><I><S><S><I><T><N><Q><E><L><K><M><M><Q><D><D><L><N><F><K><S><T><E><V><Q><K><S><Q><S><T><A><Q><N><L><T><S><D><I><Q><R><L><Q><L><D><L><Q><K><M><E><L><L><E><S><K><M><T><E><E><Q><H><S><L><K><S><K><I><K><Q><M><T><T><D><L><E><I><Y><N><D><L><P><A><L><K><S><S><G><E><E><K><I><K><K><L><H><Q><E><R><M><I><L><S><T><H><R><N><A><F><K><K><I><M><E><K><Q><N><I><E><Y><E><A><L><K><T><Q><L><Q><E><N><E><T><H><S><Q><L><T><N><L><E><R><K><W><Q><H><L><E><Q><N><N><F><A><M><K><E><F><I><A><T><K><S><Q><E><S><D><Y><Q><P><I><K><K><N><V><T><K><Q><I><A><E><Y><N><K><T><I><V><D><A><L><H><S><T><S><G><N>
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium . Binds beta-tubulin via its basic region . Required for ciliogenesis . Essential for flagellogenesis during spermatogenesis .<BOP>
Q96LB3
O00746
NDKM_HUMAN
nm23-H4
Homo
<M><G><G><L><F><W><R><S><A><L><R><G><L><R><C><G><P><R><A><P><G><P><S><L><L><V><R><H><G><S><G><G><P><S><W><T><R><E><R><T><L><V><A><V><K><P><D><G><V><Q><R><R><L><V><G><D><V><I><Q><R><F><E><R><R><G><F><T><L><V><G><M><K><M><L><Q><A><P><E><S><V><L><A><E><H><Y><Q><D><L><R><R><K><P><F><Y><P><A><L><I><R><Y><M><S><S><G><P><V><V><A><M><V><W><E><G><Y><N><V><V><R><A><S><R><A><M><I><G><H><T><D><S><A><E><A><A><P><G><T><I><R><G><D><F><S><V><H><I><S><R><N><V><I><H><A><S><D><S><V><E><G><A><Q><R><E><I><Q><L><W><F><Q><S><S><E><L><V><S><W><A><D><G><G><Q><H><S><S><I><H><P><A>
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis . Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity . Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration . Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria . In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling .<BOP>
O00746
P26441
CNTF_HUMAN
Ciliary neurotrophic factor
Homo
<M><A><F><T><E><H><S><P><L><T><P><H><R><R><D><L><C><S><R><S><I><W><L><A><R><K><I><R><S><D><L><T><A><L><T><E><S><Y><V><K><H><Q><G><L><N><K><N><I><N><L><D><S><A><D><G><M><P><V><A><S><T><D><Q><W><S><E><L><T><E><A><E><R><L><Q><E><N><L><Q><A><Y><R><T><F><H><V><L><L><A><R><L><L><E><D><Q><Q><V><H><F><T><P><T><E><G><D><F><H><Q><A><I><H><T><L><L><L><Q><V><A><A><F><A><Y><Q><I><E><E><L><M><I><L><L><E><Y><K><I><P><R><N><E><A><D><G><M><P><I><N><V><G><D><G><G><L><F><E><K><K><L><W><G><L><K><V><L><Q><E><L><S><Q><W><T><V><R><S><I><H><D><L><R><F><I><S><S><H><Q><T><G><I><P><A><R><G><S><H><Y><I><A><N><N><K><K><M>
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.<BOP>
P26441