id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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12029440 | Do chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells? | [
"Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased lev... | Expression of T beta(4) and T beta(10) mRNAs and their peptides is differentially regulated and does not correlate with growth. Instead, reduced beta-thymosin expression may be linked to more intensive TRITC-phalloidin staining of F-actin lining the membrane at sites of intimate cell-cell contacts, while increased beta... | yes |
24749853 | Does epigenome-wide DNA methylation assay reveal placental epigenetic markers for noninvasive fetal single-nucleotide polymorphism genotyping in maternal plasma? | [
"The use of DNA methylation difference between maternal blood cell and fetal (placental) DNA is one of the main areas of interest for the development of fetal epigenetics markers in maternal plasma.",
"We employed a methylation array (HumanMethylation450 array, Illumina, Inc.) to identify novel biomarkers that ar... | The present studies systematically identified hypermethylated sites in fetal tissues and preliminarily demonstrated that some of the fetal epigenetic markers that contain informative SNPs have great potential for noninvasive fetal genetic diagnosis. | yes |
24415641 | Are genetic variations in taste receptors associated with chronic rhinosinusitis : a replication study? | [
"Recent evidence implicates polymorphisms of the bitter taste receptor TAS2R38 as defining characteristics in respiratory innate defense that may contribute to the complex genetic and environmental interactions predisposing to chronic rhinosinusitis (CRS). The purpose of this study was to (1) verify whether identif... | This study replicates previous work which showed that the coding SNP rs10246939 in the TAS2R38 gene is associated with CRS. Moreover, the results suggest that other taste receptors may be implicated in CRS. Further studies using individual genotyping and sequencing, and functional studies will provide more information ... | yes |
27001269 | Does preconception Care reduce Relapse of Inflammatory Bowel Disease During Pregnancy? | [
"Women with inflammatory bowel disease (IBD) may have incorrect beliefs about their disease and its medication in relation to pregnancy. We studied the effects of preconception care (PCC) on patients' behavior during pregnancy, disease relapse during pregnancy, and birth outcomes.",
"In a prospective study, we fo... | In a prospective study, we found that preconception care reduces IBD relapse during pregnancy by promoting adherence to medication and smoking cessation. Preconception also reduces risk for babies of low birth weight. | yes |
25855995 | Does surface acoustic wave patch therapy affect tissue oxygenation in ischemic feet? | [
"Transcutaneous oxygen pressure (TcPO2) less than 30 mm Hg at the toe leads to local tissue hypoxia and nonhealing wounds. Studies regularly illustrate that TcPO2 values are strong predictors of healing and can accurately demonstrate altered levels when extremities have restricted blood flow. The objective of this ... | Surface acoustic waves as delivered in this study had a positive effect on tissue oxygenation and saturation in ischemic feet. In lower extremities that are not surgical candidates or are either in the pre- or postsurgical environment, an SAW patch device is a good therapy in elevating the extremities' O2 saturation. | yes |
20637060 | Does activin A expression regulate multipotency of mesenchymal progenitor cells? | [
"Bone marrow (BM) stroma currently represents the most common and investigated source of mesenchymal progenitor cells (MPCs); however, comparable adult progenitor or stem cells have also been isolated from a wide variety of tissues. This study aims to assess the functional similarities of MPCs from different tissue... | This comparative analysis of MPCs from different tissue sources also identifies bone marrow-derived MPCs as the most potent MPCs in terms of multilineage differentiation and immunosuppression, two key requirements in cell-based regenerative medicine. In addition, this study implicates the significance of activin A as a... | yes |
25670936 | Do patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells? | [
"Regulatory T cells (Tregs) play a key role in immune homeostasis in vivo. Tregs have a critical role in preventing the development of autoimmune diseases and defects in Treg function are implicated in various autoimmune disorders. Individuals with posttraumatic stress disorder (PTSD) have higher prevalence of auto... | Although the proportions of Tregs in PTSD patients were unchanged, we found that they exhibit a different phenotype of Tregs that might be less suppressive. Impaired differentiation and function of Tregs is likely involved in disruption of immune homeostasis in PTSD. | yes |
16609997 | Does oral administration of S-nitroso-N-acetylcysteine prevent the onset of non alcoholic fatty liver disease in rats? | [
"To evaluate the potential of S-nitroso-N-acetylcysteine (SNAC) in inhibition of lipid peroxidation and the effect of oral SNAC administration in the prevention of nonalcoholic fatty liver disease (NAFLD) in an animal model.",
"NAFLD was induced in Wistar male rats by choline-deficient diet for 4 wk. SNAC-treated... | Oral administration of SNAC prevents the onset of NAFLD in Wistar rats fed with choline-deficient diet. This effect is correlated with the ability of SNAC to block the propagation of lipid peroxidation in vitro and in vitro. | yes |
23158035 | Is number of involved lymph nodes important in the prediction of prognosis for primary duodenal adenocarcinoma? | [
"The significance of lymph node involvement regarding the prognosis of primary duodenal adenocarcinoma remains controversial. This study aims to evaluate the prognostic accuracy of nodal metastasis using the seventh edition American Joint Committee on Cancer staging system in patients with primary duodenal adenocar... | Subdivision of metastatic lymph nodes into N1 and N2 improves predictive ability. The seventh edition American Joint Committee on Cancer staging system is applicable in the present study with regard to the prediction of the prognosis for primary duodenal adenocarcinoma. | yes |
16713418 | Does two-view mammography at the incident round have improved the rate of screen-detected breast cancer in Wales? | [
"To investigate whether pre-invasive and invasive cancer detection rates were improved in Wales after the introduction of two views at incident screens.",
"The records of women attending follow-up screening for 2 years before and 2 years after the introduction of two-view incident screening were analysed. Cancer ... | Two-view mammography at incident rounds detects more cancers and more favourable prognosis small cancers than single-view mammograms. | yes |
25467995 | Does intensive unilateral core training improve trunk stability without preference for trunk left or right rotation? | [
"It is possible to increase multi-directional trunk stability using co-activation. However, it is unclear whether there is a preference for left or right trunk rotation after intensive unilateral stability training. The aim of this study was to examine the directional preference in trunk rotational stability after ... | This study showed that trunk stability improved without particular directional preference in response to unilateral core training. This result adds to our understanding of the nature of trunk stability and multi-directional improvement. | yes |
16475701 | Do cytidine-phosphate-guanosine oligodeoxynucleotides and interferon-alpha-expressing tumor cells effectively induce dendritic cell maturation in vitro? | [
"Dendritic cells (DCs) play an important role in immune response and cytidine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODN) as well as interferon (IFN)-alpha have been proven to induce DC maturation. In this study, the synergistic effects of CpG-ODN and IFN-alpha on DC maturation were evaluated.",
"Surfac... | Since CpG-ODN and IFN-alpha have synergistic effects on DC maturation, they may induce potent antitumor immune responses and combination therapy should be considered for clinical application. | yes |
17604363 | Is peginterferon alpha-2b safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis? | [
"Chronic hepatitis B (CHB) patients with advanced fibrosis are often not considered for treatment with peginterferon (PEG-IFN) because IFN therapy may precipitate immunological flares, potentially inducing hepatic decompensation. We investigated the efficacy and safety of treating hepatitis B e antigen (HBeAg)-posi... | PEG-IFN is effective and safe for HBeAg-positive patients with advanced fibrosis. Because PEG-IFN therapy results in a high rate of sustained off-therapy response, patients with advanced fibrosis or cirrhosis but compensated liver disease should not be excluded from PEG-IFN treatment. | yes |
23330889 | Is the required written history and physical alive , but not entirely well , in internal medicine clerkships? | [
"Effective written communication is a core competency for medical students, but it is unclear whether or how this skill is evaluated in clinical clerkships.",
"This study identifies current requirements and practices regarding required written work during internal medicine clerkships.",
"In 2010, Clerkship Dire... | Despite near universal requirements for student written work, structured evaluation was not commonly performed, raising concern about the validity of factoring these assessments into grades. | yes |
25801975 | Does nitric oxide affect UbcH10 levels differently in type 1 and type 2 diabetic rats? | [
"Nitric oxide (NO) more effectively inhibits neointimal hyperplasia in type 2 diabetic versus nondiabetic and type 1 diabetic rodents. NO also decreases the ubiquitin-conjugating enzyme UbcH10, which is critical to cell-cycle regulation. This study seeks to determine whether UbcH10 levels in the vasculature of diab... | These data suggest a disconnect between UbcH10 levels and neointimal hyperplasia formation in type 2 diabetic models and contribute valuable insight regarding differential efficacy of NO in these models. | yes |
7594438 | Does endogenous angiotensin within the rostral ventrolateral medulla facilitate the somatosympathetic reflex? | [
"To determine whether endogenous angiotensin modifies the synaptic excitation of sympatho-excitatory neurons in the rostral part of the ventrolateral medulla.",
"Experiments were performed on anaesthetized rabbits with denervated arterial and cardiopulmonary baroreceptors. Arterial pressure, heart rate and renal ... | The results indicate that, in the anaesthetized rabbit with denervated arterial and cardiopulmonary baroreceptors, endogenous angiotensin is tonically released within the rostral ventrolateral medulla and facilitates the synaptic excitation of sympatho-excitatory neurons reflexly evoked by stimulation of afferent fibre... | yes |
12022012 | Do local visual field defects correlate with the multifocal electroretinogram ( mfERG ) in retinal vascular branch occlusion? | [
"The value of multifocal electroretinography (mfERG) in the detection of localized retinal dysfunction in vascular branch disease at the posterior pole of the eye is investigated, and mfERG is compared with visual field defects.",
"10 eyes of 7 patients were tested, of which 8 eyes had a branch retinal vein occlu... | Local visual field defects in retinal vascular branch occlusion correlate well with mfERG if suitable criteria are applied. | yes |
19672104 | Does endothelial ET ( B ) limit vascular remodelling and development of pulmonary hypertension during hypoxia? | [
"We hypothesised that the potential protective effects of endothelial ET(B) are important in limiting pulmonary vascular muscularisation, vasoconstriction and the development of pulmonary arterial hypertension in response to hypoxia.",
"EC-specific ET(B) knockout mice (EC ET(B)(-/-)) and control mice (ET(B)(f/f))... | The potential protective effects of endothelial ET(B) are important in limiting pulmonary vascular muscularisation and the development of pulmonary arterial hypertension in response to hypoxia. | yes |
19351756 | Does fDG-PET/CT imaging predict histopathologic treatment responses after the initial cycle of neoadjuvant chemotherapy in high-grade soft-tissue sarcomas? | [
"In patients with soft-tissue sarcoma (STS), the early assessment of treatment responses is important. Using positron emission tomography/computed tomography (PET/CT) with [(18)F]fluorodeoxyglucose (FDG), we determined whether changes in tumor FDG uptake predict histopathologic treatment responses in high-grade STS... | A 35% reduction in tumor FDG uptake at early follow-up is a sensitive predictor of histopathologic tumor response. Early treatment decisions such as discontinuation of chemotherapy in nonresponding patients could be based on FDG-PET criteria. | yes |
20509929 | Does combinatorial gene therapy render increased survival in cirrhotic rats? | [
"Liver fibrosis ranks as the second cause of death in México's productive-age population. This pathology is characterized by accumulation of fibrillar proteins in hepatic parenchyma causing synthetic and metabolic disfunction. Remotion of excessive fibrous proteins might result in benefit for subjects increasing su... | A single administration of Ad-delta-huPA plus Ad-MMP-8 is efficient to induce fibrosis regression and increase survival in experimental liver fibrosis. | yes |
23742289 | Is proMetalloproteinase-10 associated with brain damage and clinical outcome in acute ischemic stroke? | [
"Matrix metalloproteinases (MMPs) mediate tissue injury during stroke but also neurovascular remodeling and we have shown that MMP-10 is involved in atherothrombosis.",
"The purpose of this study was to examine the relationship between proMMP-10 and clinical outcome, assessing inflammatory and proteolytic markers... | Increased serum proMMP-10 after acute ischemic stroke, associated with TNFα, is a new marker of brain damage and poor outcome. | yes |
19672262 | Are angiogenesis and lymphangiogenesis downregulated in primary breast cancer? | [
"Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept of tumour angiogenesis and lymphangiogenesis by analysing the expression of c... | Primary breast tumours are not a site of highly active angiogenesis and lymphangiogenesis. Selection for tumour cells that survive with minimal vascular supply may account for this observation in clinical apparent tumours. | yes |
19235910 | Is fcRL3 gene promoter variant associated with peripheral arthritis in Crohn 's disease? | [
"The mechanisms responsible for the pathogenesis of peripheral arthropathies (PA) in Crohn's disease (CD) are largely unknown, although many studies indicate that genetic and environmental factors are likely to contribute to risk.",
"Because variants in the Fc receptor-like 3 (FcRL3) gene have recently been assoc... | We found that female sex, colonic involvement, and the AA genotype at -110 G>A were associated with increased risk of both subtypes of PA, although the association appears to be stronger for arthritis than for arthralgia. | yes |
23908067 | Is mMP9 variation after thrombolysis associated with hemorrhagic transformation of lesion and death? | [
"Experimentally, matrix metalloproteinases (MMPs) play a detrimental role related to hemorrhagic transformation and severity of an ischemic brain lesion. Tissue-type plasminogen activator (tPA) enhances such effects. This study aimed to expand clinical evidence in this connection.",
"We measured MMPs 1, 2, 3, 7, ... | Our clinical evidence corroborates the detrimental role of matrix metalloproteinase-9 during ischemic stroke treated with thrombolysis, and prompts clinical trials testing agents antagonizing its effects. | yes |
22102159 | Do purple corn anthocyanins retard diabetes-associated glomerulosclerosis in mesangial cells and db/db mice? | [
"Diabetic glomerulosclerosis is the hardening of the renal glomeruli that can lead to kidney failure. In the early stage of glomerulosclerosis occur renal mesangial expansion and renal filtration dysfunction. Purple corn has been classified as a functional food and is rich in anthocyanins exerting potential disease... | Purple corn may be a potent therapeutic agent for the treatment for diabetes-associated glomerulosclerosis accompanying proteinuria and kidney filtration dysfunction. | yes |
18473417 | Is down-regulation of transforming growth factor beta 1/activin receptor-like kinase 1 pathway gene expression by herbal compound 861 related to deactivation of LX-2 cells? | [
"To investigate the effect of herbal compound 861 (Cpd861) on the transforming growth factor-beta1 (TGF beta 1)/activin receptor-like kinase 1 (ALK1, type I receptor) signaling-pathway-related gene expression in the LX-2 cell line, and the inhibitory mechanism of Cpd861 on the activation of LX-2 cells.",
"LX-2 ce... | Cpd861 can restrain the activation of LX-2 cells by inhibiting the TGF beta 1/ALK1/Smad1 pathway. | yes |
8607897 | Is the superficial layer of human articular cartilage more susceptible to interleukin-1-induced damage than the deeper layers? | [
"To compare the responses of chondrocytes from superficial and deep layers of normal human articular cartilage to interleukin-1 (IL-1) and IL-1 receptor antagonist protein (IRAP), and to evaluate the binding sites for IL-1 on these cells.",
"Cartilage and chondrocytes from superficial and deeper layers of human f... | Chondrocytes from the surface of articular cartilage show a greater vulnerability to the harmful effects of IL-1 and are less responsive to the potential therapeutic effects of IRAP than cells in the deeper layers of the tissue. | yes |
25867520 | Do silver dressings improve diabetic wound healing without reducing bioburden? | [
"Introduction. Silver dressings are widely used in the treatment of chronic wounds to reduce bacterial bioburden. However, little is known about the mechanism of silver ions on the healing process. In this study, a mouse model of wound healing was used to examine the effect of silver dressings in normal and diab... | The results demonstrate improved healing and reduced bioburden in normal wounds with silver dressings. In contrast, silver dressings improved healing in diabetic wounds despite no effect on bioburden, suggesting silver may have beneficial effects in addition to its antimicrobial properties. | yes |
11473633 | Does a novel somatostatin analogue prevent early renal complications in the nonobese diabetic mouse? | [
"PTR-3173 (S) is a novel somatostatin analogue that has been found to exert a prolonged inhibitory action on the growth hormone (GH)-insulin-like growth factor (IGF)-I axis, but not on insulin secretion. We investigated the potential effect of this agent on the development of markers of diabetic nephropathy in the ... | GH antagonism by PTR-3173 has a blunting effect on renal/glomerular hypertrophy, albuminuria, and glomerular filtration rate (GFR) in diabetic NOD mice. This phenomenon is apparently associated with the prevention of renal IGF-I accumulation. Thus, modulation of GH effects may have beneficial therapeutic implications i... | yes |
16374289 | Does topical becaplermin improve outcomes in work related fingertip injuries? | [
"Fingertip injuries are common and bear significant costs associated with treatment, lost work, and functional impairment. This study compared these factors in occupationally related fingertip injuries treated with becaplermin, a recombinant human platelet-derived growth factor, and those treated with surgical reco... | In this study, the functional and economic costs were significantly less when fingertip injuries were treated with topical becaplermin than when they were treated with surgical reconstruction. This information should allow emergency and acute care physicians to treat these injuries more efficaciously and conveniently. | yes |
21071740 | Does integrin-linked kinase regulate integrin signaling in human trabecular meshwork cells? | [
"To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling.",
"The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, respectiv... | This study suggests that cooperative α5β1/α4β1 integrin signaling may be regulated by ILK trans-dominantly and that alterations in ILK activity may affect actin cytoskeleton organization and contractility in the TM. | yes |
27702720 | Is coffee consumption associated with lower serum aminotransferases in the general Korean population and in those at high risk for hepatic disease? | [
"The favourable effects of coffee on liver enzymes have been reported worldwide. This study investigated the association between coffee consumption and serum aminotransferase concentration in Korean adults.",
"Data were obtained from the fourth and fifth Korea National Health and Nutrition Examination Surveys. El... | Higher coffee consumption was associated with lower risk of elevated aminotransferase concentration in Korean adults. | yes |
26716984 | Is a20 Mutation a Prognostic Marker for Activated B-Cell-Like Diffuse Large B-Cell Lymphoma? | [
"Constitutive activation of nuclear factor κB (NF-κB) is a hallmark of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL). Mutations in the A20 gene activate NF-κB, but the prognostic value of A20 mutations in ABC-DLBLC is unclear.",
"To investigate the prognostic value of A20 mutation in ABC-DLBCL p... | Our findings suggested that the A20 mutation is a frequent event in ABC-DLBCLs. However, there was no significant difference in PFS and OS in patients with or without A20 mutations. Further study is required to completely exclude A20 somatic mutation as a prognostic marker in the ABC subtype of DLBLC. | no |
12552361 | Is increased extracellular serotonin level in rat hippocampus induced by chronic citalopram augmented by subchronic lithium : neurochemical and behavioural studies in the rat? | [
"A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentation strategy. However, the neurochemical rationale behind this strategy needs to be further clarified.",
"We examined the effect of chronic citalopram and subchron... | The present results support the assumption that increases in hippocampal 5-HT neurotransmission may be important in the augmentatory effect of lithium. | yes |
10430764 | Is respiratory muscles performance related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure? | [
"Dyspnea and fatigue are the main causes of exercise limitation in chronic heart failure (CHF) patients, whose peak inspiratory (Pi(max)) and expiratory pressures (Pe(max)) are often reduced. The aim of this study was to examine the relationship between respiratory muscle performance and oxygen kinetics.",
"A tot... | The reduction of Pi(max) after exercise is associated with prolonged early recovery of oxygen kinetics, which may explain, in part, the role played by respiratory muscles in exercise intolerance in CHF patients. | yes |
23159231 | Do two apolipoprotein E mimetic peptides with similar cholesterol reducing properties exhibit differential atheroprotective effects in LDL-R null mice? | [
"We investigated two apoE mimetic peptides with similar long-term plasma cholesterol reducing abilities for their effects on atherosclerotic lesions in Western diet-fed female LDL-receptor (LDL-R) null mice.",
"Single doses of peptides Ac-hE18A-NH(2) and mR18L were administered retro-orbitally to LDL-R null mice ... | Despite similar reductions in plasma cholesterol levels, Ac-hE18A-NH(2) was more effective in inhibiting lesions than mR18L, possibly due to its ability to promote the secretion of apoE from hepatocytes and macrophages. | yes |
11373920 | Is the effect of dexamethasone on respirator-dependent very-low-birth-weight infants best predicted by chest X-ray? | [
"Chronic lung disease (CLD) in premature infants shows a variable clinical course with different radiological manifestations.",
"To evaluate the correlation between parameters of trans-membrane permeability [albumin/secretory component (SC)] and oxidative stress [malondialdehyde (MDA)/SC] in tracheal aspirate flu... | The optimum timing of dexamethasone treatment may be determined by the stage of developing CLD and radiological findings rather than by the age of the premature infant. | yes |
23227900 | Is alternative splicing of the neurofibromatosis type 1 pre-mRNA regulated by the muscleblind-like proteins and the CUG-BP and ELAV-like factors? | [
"Alternative splicing is often subjected to complex regulatory control that involves many protein factors and cis-acting RNA sequence elements. One major challenge is to identify all of the protein players and define how they control alternative expression of a particular exon in a combinatorial manner. The Muscleb... | This study along with our previous work that demonstrated roles for Hu, CELF, and TIA-1 and TIAR proteins in the regulation of NF1 exon 23a establish that this exon is under tight, complex control. | yes |
26197762 | Does improvement in quality of life after robotic surgery result in patient satisfaction? | [
"There are well-described benefits to minimally invasive surgery including decreased blood loss, shorter hospital-stay, and faster recovery. The role of robotic surgery in gynecologic oncology has become increasingly prominent; however limited data are available on quality of life (QOL) after robotic surgery.",
"... | In this prospective study, general health, symptom burden and sexual function returned to or improved beyond baseline levels within 6 weeks of surgery. Overall, women were satisfied with their decision to undergo robotic surgery. | yes |
20543019 | Are butler 's neuromobilizations combined with proprioceptive neuromuscular facilitation effective in reducing of upper limb sensory in late-stage stroke subjects : a three-group randomized trial? | [
"Are Butler's neuromobilizations combined with proprioceptive neuromuscular facilitation and traditional post-stroke therapy more effective in reducing affected upper extremity sensory deficits in late-stage stroke subjects than proprioceptive neuromuscular facilitation combined with traditional therapy or traditio... | In our subjects, application of Butler's neuromobilizations combined with proprioceptive neuromuscular facilitation showed greater effectiveness in reducing sensory deficits than proprioceptive neuromuscular facilitation or traditional therapy alone. | yes |
19233700 | Is seroreactivity to specific antigens of Helicobacter pylori infection associated with an increased risk of the dyspeptic gastrointestinal diseases? | [
"The correlation between seroreactivity to Helicobacter pylori-specific antigens and clinical outcomes in gastrointestinal disease remains unresolved. We investigated the anti-H. pylori antibody profile in northeast Thai dyspeptic patients with gastrointestinal disease in order to identify any H. pylori antigens th... | We confirm that the universal presence of CagA and VacA in H. pylori-infected patients in Thailand is independent of the gastroduodenal disease. The presence or absence of antibodies to H. pylori-specific antigens may be useful as indirect markers in the screening of H. pylori-infected patients, and may have specific p... | yes |
15762984 | Does chronic ethanol exposure increase microtubule content in PC12 cells? | [
"Chronic ethanol exposure has been shown to result in changes in neuronal cyto-architecture such as aberrant sprouting and alteration of neurite outgrowth. In PC12 cells, chronic ethanol treatment produces an increase in Nerve Growth Factor (NGF)-induced neurite outgrowth that appears to require the epsilon, but no... | These results suggest that chronic ethanol exposure alters the relative ratio of free tubulin to microtubule-associated tubulin, an important component of the cytoskeleton. Further, the data from the PKC dominant-negative cell lines suggest that the effects of ethanol on microtubule content do not correlate with the ef... | yes |
20439508 | Do mRI-based attenuation correction for PET/MRI using ultrashort echo time sequences? | [
"One of the challenges in PET/MRI is the derivation of an attenuation map to correct the PET image for attenuation. Different methods have been suggested for deriving the attenuation map from an MR image. Because the low signal intensity of cortical bone on images acquired with conventional MRI sequences makes it d... | The feasibility of using the transverse relaxation rate map derived from ultrashort echo time MR images for the estimation of the attenuation map was shown on phantom and clinical brain data. The results indicate that the new method, compared with CT-based attenuation correction, yields clinically acceptable errors. Th... | yes |
19756814 | Is diagnostic performance of magnetic resonance first pass perfusion imaging equally potent in female compared to male patients with coronary artery disease? | [
"Noninvasive diagnosis of coronary artery disease (CAD) in women is crucial because of a lower prevalence of CAD in premenopausal women, different cardiac risk profile and pattern of CAD, lower exercise tolerance and more atypical symptoms compared to men. Therefore, we tested the diagnostic power of cardiac magnet... | Diagnostic accuracy of CMR-FPPI is very high in women with intermediate risk of CAD and comparable or in part superior to results in males. With the advantage of the absence of radiation exposure and high spatial and temporal resolution, CMR-FPPI has the potential to become the preferred imaging test to select women fo... | yes |
22857879 | Is periostin a systemic biomarker of eosinophilic airway inflammation in asthmatic patients? | [
"Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We recently described a distinct subtype of asthma defined by the expression of genes inducible by T(H)2 cytokines in bronchial epithelium. This gene signature, which includes periostin, is present in approximately half of asthmatic patients ... | Periostin is a systemic biomarker of airway eosinophilia in asthmatic patients and has potential utility in patient selection for emerging asthma therapeutics targeting T(H)2 inflammation. | yes |
16515710 | Does 10 Hz flicker improve recognition memory in older people? | [
"10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in older peop... | The frequency-specificity of flicker's effects in our participants paralleled the power spectrum of EEG alpha in the general population. This indicates that alpha-like EEG activity may subserve memory processes. Flicker may be able to help memory problems in older people. | yes |
10746405 | Does endotoxemia augment neurogenic plasma exudation in guinea pig lungs? | [
"Lipopolysaccharide (LPS) is closely associated with the development of infection-induced deleterious pulmonary reactions. In this study, we investigated the enhancement effects of LPS on tachykinin-mediated plasma exudation in the lungs of guinea pigs. The role of oxidants was also explored.",
"Intravenous LPS (... | LPS augments neurogenic plasma exudation partly through NK-1 receptors to increase vascular permeability and partly via the generation of oxidative metabolites. Tachykinins released from nerve endings may contribute to endotoxin-related pulmonary inflammatory responses. | yes |
22436263 | Do radiation-induced carotid stenotic lesions have a more stable phenotype than de novo atherosclerotic plaques? | [
"To identify plaque characteristics of carotid artery radiation-induced stenosis.",
"Nineteen carotid plaques were obtained during carotid endarterectomy (CEA) in 17 consecutive patients with prior cervical radiation therapy (XRT) (median interval 10 years) and compared with 95 matched control carotid plaques of ... | Carotid stenotic lesions in patients with previous cervical radiation are less inflammatory and more fibrotic than carotid atherosclerotic lesions in non-radiated patients. | yes |
24729993 | Is iron overload rare in patients homozygous for the H63D mutation? | [
"Previous research has suggested that the H63D HFE mutation is associated with elevated iron indexes. However, the true penetrance of this mutation remains unclear.",
"To assess the proportion of H63D homozygotes with laboratory abnormalities consistent with iron overload.",
"The present study was a retrospecti... | H63D homozygosity was associated with an elevated mean ferritin level, but only 6.7% had documented iron overload at follow-up. The penetrance of the H63D mutation appeared to be low. | yes |
19619339 | Is carbonic anhydrase 9 a predictive marker of survival benefit from lower dose of bevacizumab in patients with previously treated metastatic colorectal cancer? | [
"Carbonic anhydrase 9 (CA9) is a marker for hypoxia and acidosis, which is linked to a poor prognosis in human tumors. The purpose of this comparative analysis was to evaluate whether CA9 and VEGF expression are associated with survival outcomes in patients with metastatic colorectal cancer (mCRC) after treatment w... | Lower degree of CA9 expression was associated with better clinical outcomes in patients with mCRC treated with lower dose bevacizumab-based chemotherapy. Prospective studies are now needed to determine the correlation between CA9 expression and clinical outcomes after bevacizumab treatment, at different doses and in va... | yes |
22228320 | Does exogenous estrogen protect mice from the consequences of obesity and alcohol? | [
"Breast cancer is the second leading cause of cancer death among American women. Risk factors for breast cancer include obesity, alcohol consumption, and estrogen therapy. In the present studies, we determine the simultaneous effects of these three risk factors on wingless int (Wnt)-1 mammary tumor growth.",
"Ova... | In summary, we show that estrogen protects against obesity, which is associated with the inhibition of fatty liver and tumor growth. | yes |
25138053 | Does clusterin inhibition using OGX-011 synergistically enhance zoledronic acid activity in osteosarcoma? | [
"Despite recent improvements in therapeutic management of osteosarcoma, ongoing challenges in improving the response to chemotherapy warrants new strategies still needed to improve overall patient survival. Among new therapeutic approaches, zoledronic acid (ZOL) represents a promising adjuvant molecule to chemother... | These results indicate that ZOL-mediated induction of CLU can be attenuated by OGX-011, with synergistic effects on delaying progression of osteosarcoma. | yes |
12885984 | Is resolution of bronchial inflammation related to bacterial eradication following treatment of exacerbations of chronic bronchitis? | [
"Recent studies of the role of bacteria in chronic bronchitis have shown that bacterial colonisation is associated with enhanced inflammation and that purulent acute exacerbations of chronic bronchitis (AECB) are associated with bacteria and characterised by increased inflammation. Changes in bronchial inflammation... | Resolution of bronchial inflammation following AECB is related to bacterial eradication. Those in whom bacteria continue to be cultured in their sputum have partial resolution of inflammation which may reflect continued stimulation by the reduced bacterial load. | yes |
22079948 | Is total epinephrine dose during asystole and pulseless electrical activity cardiac arrests associated with unfavourable functional outcome and increased in-hospital mortality? | [
"Epinephrine is the drug of choice during advanced cardiac life support. The cumulative dose of epinephrine applied during resuscitation was shown to be independently associated with unfavourable outcome after ventricular fibrillation cardiac arrest in humans. Our objective was to investigate the association betwee... | Our results show that an increasing cumulative dose of epinephrine during resuscitation of patients with asystole and pulseless electric activity is an independent risk factor for unfavourable functional outcome and in-hospital mortality. | yes |
20031959 | Does the gene expression profile of patients with new-onset heart failure reveal important gender-specific differences? | [
"We sought to test the hypothesis that inherent biological factors contribute to gender differences in disease pathophysiology of new-onset heart failure (HF), which can be detected from the transcriptome of a single endomyocardial biopsy (EMB).",
"We analysed samples from male (n = 29) and female patients (n = 1... | This is the first study that identified gender-specific transcriptomic differences in new-onset HF. Our findings may offer novel insights into fundamental biological differences in the pathophysiology of HF between sexes and provide a platform for personalized medicine. | yes |
19545716 | Are an early increase in gamma glutamyltranspeptidase and low aspartate aminotransferase peak values associated with superior outcomes after orthotopic liver transplantation? | [
"Prediction of prognosis after liver transplantation (OLT) remains difficult. The present study determines if standard laboratory parameters measured within the first week after OLT correlate with outcome.",
"Laboratory parameters measured within the first weak after OLT of 328 patients were grouped either graft ... | Unexpectedly, a disproportionate rise in gamma-GT was associated with graft and patient survival of more than 90 days. This might be explained by regeneration phenomena in the liver indicative of a well functioning graft. | yes |
16305727 | Are multidrug resistance 1 gene polymorphisms associated with inflammatory bowel disease and response to therapy in Italian patients? | [
"Host genetic factors may be important in determining not only disease susceptibility, but also disease behaviour and response to therapy in inflammatory bowel disease. Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and func... | The investigated polymorphisms of the multidrug resistance 1 gene have no significant role in disease susceptibility and response to medical therapy in our Italian population of inflammatory bowel disease patients. | no |
25595053 | Is brief overdose education sufficient for naloxone distribution to opioid users? | [
"While drug users are frequently equipped with naloxone for lay opioid overdose reversal, the amount of education needed to ensure knowledge of indications and administration is unknown.",
"We administered four instruments, assessing comfort and knowledge around opioid overdose and naloxone administration, to opi... | Opioid users seeking naloxone in San Francisco have a high level of baseline knowledge around recognizing and responding to opioid overdose and those returning for refills retain that knowledge. Brief education is sufficient to improve comfort and facility in recognizing and managing overdose. | yes |
25355401 | Does development of a communication protocol for telephone disclosure of genetic test result for cancer predisposition? | [
"Dissemination of genetic testing for disease susceptibility, one application of \"personalized medicine\", holds the potential to empower patients and providers through informed risk reduction and prevention recommendations. Genetic testing has become a standard practice in cancer prevention for high-risk populati... | Analyses of stakeholders' experiences and audiotapes of telephone disclosure of BRCA1/2 test results informed revisions to communication strategies and a protocol to enhance patient outcomes when utilizing telephone to disclose genetic test results. | yes |
16564282 | Does diazoxide provide maximal KATP channels independent protection if present throughout hypoxia? | [
"It is not clear what the optimal timing of diazoxide administration for cardioprotection in human myocardium is. We aimed to establish it. We next checked whether protection depended on adenosine triphosphate (ATP)-inhibited potassium (KATP) channels.",
"Isolated human right atrial trabeculae were subjected to 9... | Administration of diazoxide throughout hypoxia provided maximal protective effect, suggesting that diazoxide may be an important adjunct to cardioplegic solution. The protection offered by diazoxide used during hypoxia appears independent of its influence on KATP channels. | yes |
24345828 | Are eEG abnormalities associated with increased risk of transplant or poor outcome in children with acute liver failure? | [
"There are limited data on the incidence of seizures and utility of brain imaging and electroencephalogram (EEG) to predict outcome of children with acute liver failure (ALF). We investigated the association between hepatic encephalopathy (HE) scores, abnormal EEG or neuroimaging, and short-term outcome.",
"Singl... | Children with a moderate or severe abnormality of EEG background on admission were significantly more likely to require LT or to die. Children with an HE score ≤ 2, and a normal or only mildly abnormal EEG, were significantly more likely to survive without needing LT. These findings are an initial step toward distingui... | yes |
23967114 | Does validity of physician billing claim to identify deceased organ donors in large healthcare databases? | [
"We evaluated the validity of physician billing claims to identify deceased organ donors in large provincial healthcare databases.",
"We conducted a population-based retrospective validation study of all deceased donors in Ontario, Canada from 2006 to 2011 (n = 988). We included all registered deaths during the s... | Primary data abstraction to identify deceased organ donors should be used whenever possible, particularly for the detection of organ-specific donations. The limitations of physician billing claims should be considered whenever they are used. | yes |
25181026 | Does intrapersonal positive future thinking predict repeat suicide attempts in hospital-treated suicide attempters? | [
"Although there is clear evidence that low levels of positive future thinking (anticipation of positive experiences in the future) and hopelessness are associated with suicide risk, the relationship between the content of positive future thinking and suicidal behavior has yet to be investigated. This is the first s... | Positive future thinking has predictive utility over time; however, the content of the thinking affects the direction and strength of the positive future thinking-suicidal behavior relationship. Future research is required to understand the mechanisms that link high levels of intrapersonal positive future thinking to s... | yes |
19156222 | Is frequency of regulatory T cells affected by transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis? | [
"Transient B cell depletion with the monoclonal anti-CD20 antibody rituximab has shown favourable clinical responses in patients with rheumatoid arthritis (RA). Recently a characteristic regeneration pattern of B cell subpopulations has been reported. However, little is known about the impact of B-cell depletion on... | Absolute T cell counts showed no significant changes after rituximab compared to the time point before therapy.In particular, the frequency of regulatory T cells with a CD4+CD25++ phenotype as well as positive Foxp3 expression were numerically stable. Additionally, HLA-G positive regulatory T cells and soluble levels o... | no |
24829071 | Are cardiovascular disease risk factors elevated in urban minority children enrolled in head start? | [
"The prevalence of obesity and overweight persists in the preschool population, despite some prevention and treatment advances, particularly in minorities. Investigating the prevalence of dyslipidemia and the effect of family health may also guide the focus of intervention efforts.",
"Anthropometric data were col... | Continued efforts to treat and prevent elevated weight are urgently needed for minority preschoolers. Attention to CVD screening may be an important target in school, community, and healthcare arenas for minority populations regardless of weight status. | yes |
15295858 | Does thyroid cancer have increased in the adult populations of countries moderately affected by Chernobyl fallout? | [
"The incidence of thyroid carcinoma increased among children affected by Chernobyl fallout. Less evidence exists for a corresponding effect in adolescents and adults. The Cancer Registry of the Czech Republic provides an opportunity to study various determinants of the occurrence of thyroid cancer.",
"Anonymous p... | Although the Czech Republic received only a relatively moderate amount of radioactive fallout,an unexpected uniformly accelerated increase of thyroid cancer in all age categories is seen from 1990 onwards. Therefore one should look carefully at collective dose and at the group of persons low in individual organ dose bu... | yes |
22847100 | Do checklists change communication about key elements of patient care? | [
"Combat casualty care is distributed across professions and echelons of care. Communication within it is fragmented, inconsistent, and prone to failure. Daily checklists used during intensive care unit (ICU) rounds have been shown to improve compliance with evidence-based practices, enhance communication, promote c... | Checklists modify communication patterns. Improved communication facilitated by checklists may be one mechanism behind their effectiveness. Checklists are powerful tools that can rapidly alter patient care delivery. Implementing checklists could facilitate the rapid dissemination of clinical practice changes, improve c... | yes |
20738181 | Does self-microemulsifying drug delivery system improve curcumin dissolution and bioavailability? | [
"Curcumin has a wide spectrum of biological and pharmacological activities, but it has not yet been approved as a therapeutic agent because of its low solubility and stability in aqueous solution, and the relatively low bioavailability in vivo. To overcome these limitations, self-microemulsifying drug delivery syst... | The SMEDDS can significantly increase curcumin dissolution in vitro and bioavailability in vivo. | yes |
16522928 | Do cooking and Fe fortification have different effects on Fe bioavailability of bread and tortillas? | [
"To identify iron sources for wheat- (WF) and corn-flour (CF) fortification taking into account the effect of cooking.",
"Sixty-six Fe-depleted rats were replete with various Fe sources. Fe bioavailability and utilization in wheat bread (WB) and corn tortillas (CT) fortified with various Fe sources was assessed a... | We concluded that baking WF bread improved the bioavailability of native Fe with no further effect of fortification. Pan-cooking of lime-treated CF did not improve Fe bioavailability, but addition of Ferrous sulfate or NaFe(III)EDTA did it, despite the high phytate and calcium content of tortillas. | yes |
9028151 | Does vitamin E modify neither fructosamine nor HbA1c levels in poorly controlled diabetes? | [
"To examine the effects of vitamin E on total serum protein glycation (fructosamine), hemoglobin glycation (HbA1c), and serum levels of glucose, total cholesterol, triglycerides, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B.",
"Sixty poorly controlled diabetic patients were randomly assigned to receive ei... | No significant effects of vitamin E on any of the parameters evaluated were observed in poorly controlled diabetic patients. | yes |
18194187 | Are remembered International Index of Erectile Function domain scores accurate in assessing preoperative potency in candidates for bilateral nerve-sparing radical retropubic prostatectomy? | [
"The reliability of reported postoperative data in patients undergoing nerve-sparing radical retropubic prostatectomy is often limited because the degree of sexual function (SF) has not been assessed objectively both before and after treatment. Most reports include only a retrospective chart review, and there is a ... | Because of the lack of significant agreement between remembered and real-time IIEF scores, the present findings indicate that remembered IIEF should not be used to assess SF in a real-life clinical setting in candidates for BNSRRP. | no |
22492981 | Does multidrug resistance-linked gene signature predict overall survival of patients with primary ovarian serous carcinoma? | [
"This study assesses the ability of multidrug resistance (MDR)-associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large set of genes was evaluated whose expression ... | This study reveals an 11-gene signature that allows a more precise prognosis for patients with serous cancer of the ovary treated with carboplatin- and paclitaxel-based therapy. These 11 new targets offer opportunities for new therapies to improve clinical outcome in ovarian cancer. | yes |
17542117 | Does nutrition education alone improve dietary practices but not hematologic indices of adolescent girls in Iran? | [
"Iron-deficiency anemia is the most prevalent nutritional deficiency worldwide. Iron-deficiency anemia has particular negative consequences on women in their childbearing years, and its prevention is a high priority in most health systems.",
"This interventional study assessed the effect of nutrition education on... | These findings indicate that nutritional education can improve knowledge of healthy nutrition and lifestyle choices. Focused nutritional education using available resources and correcting current dietary habits in a vulnerable group of young women may result in dietary changes that can ultimately improve iron intake. | yes |
25436304 | Is decreased expression of liver-type fatty acid-binding protein associated with poor prognosis in hepatocellular carcinoma? | [
"The purpose of this study was to assess liver-type fatty acid-binding protein (L-FABP) expression and its association with clinicopathological features in hepatocellular carcinoma (HCC).",
"L-FABP mRNA expression in 57 samples of HCC and corresponding adjacent liver tissue and 8 normal liver tissue samples were ... | L-FABP was downregulated in HCC and could be served as a promising prognostic marker for HCC patients. | yes |
19818783 | Does loss or silencing of the PHD1 prolyl hydroxylase protect livers of mice against ischemia/reperfusion injury? | [
"Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and p... | Loss of PHD1 provided tolerance of hepatocytes to acute hypoxia and protected them against I/R-damage. Short-term inhibition of PHD1 is a novel therapeutic approach to reducing or preventing I/R-induced liver injury. | yes |
20657771 | Does a gammaherpesvirus complement regulatory protein promote initiation of infection by activation of protein kinase Akt/PKB? | [
"Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 deposition. Besides complement regulation, these proteins are invol... | In summary, our studies demonstrate that ORF4 contributes to efficient infection by activation of the protein kinase Akt and thus reveal a novel function of a gammaherpesvirus RCA protein. | yes |
15084543 | Does left ventricular pacing improve haemodynamic variables in patients with heart failure with a normal QRS duration? | [
"To assess whether patients with congestive heart failure (CHF) and a normal QRS duration can benefit from left ventricular (VDD-LV) pacing.",
"Cardiac resynchronisation is reserved for patients with a broad QRS duration on the premise that systolic resynchronisation is the mechanism of benefit, yet improvement f... | Patients with CHF with a normal QRS duration and PCWP > 15 mm Hg derive acute haemodynamic benefit from VDD-LV pacing. | yes |
22921695 | Does high dietary magnesium intake decrease hyperoxaluria in patients with nephrolithiasis? | [
"To examine the relationship between urine magnesium and hyperoxaluria in a cohort of patients with recurrent stone formation.",
"A total of 311 patients with nephrolithaisis were evaluated. The patients were divided into quintiles of urine magnesium excretion, an accepted surrogate of dietary magnesium intake. M... | Increasing magnesium intake was associated with decreasing hyperoxaluria in this population of patients with stone formation. Our findings showed that high magnesium intake might be required to observe clinically significant effects from magnesium. | yes |
16863846 | Does urinary trypsin inhibitor present in fetal urine prevent intraamniotic meconium-induced intestinal damage in gastroschisis? | [
"Contact with amniotic fluid causes intestinal damage in gastroschisis, and intraamniotic meconium has been shown to be responsible. Meconium has been shown to contain a significant amount of IL-8, which may be the responsible cytokine for harmful effects of meconium. Neonatal urine contains high amount of urinary ... | Urinary trypsin inhibitor 100 U/mL prevented the intestinal damage via inhibiting IL-8, which is contained by 1:400 concentration of meconium. Therefore, besides the existence of threshold level of meconium, the existence of UTI, which is capable of inhibiting IL-8 contained by threshold level of meconium, may be a fac... | yes |
22023348 | Do low fatty acid concentrations in neonatal cord serum correlate with maternal serum? | [
"Lactating women in New Mexico have low levels of important fatty acids relative to reported international data. The objective was to correlate the proportions of long-chain polyunsaturated fatty acids (LCPUFA) in the serum phospholipids in mothers and newborns within the same population.",
"The serum phospholipi... | In the setting of low maternal levels of important fatty acids, their newborns did not accrue serum levels equivalent to reported international values. | yes |
27128347 | Does exposure to Fine Particulate Air Pollution cause Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress? | [
"Epidemiological evidence suggests that exposure to ambient air fine particulate matter (PM2.5) increases the risk of developing type 2 diabetes and cardiovascular disease. However, the mechanisms underlying these effects of PM2.5 remain unclear.",
"We tested the hypothesis that PM2.5 exposure decreases vascular ... | Short-term exposure to PM2.5 induces vascular insulin resistance and inflammation triggered by a mechanism involving pulmonary oxidative stress. Suppression of vascular insulin signaling by PM2.5 may accelerate the progression to systemic insulin resistance, particularly in the context of diet-induced obesity. Citation... | yes |
22506056 | Does nitroxyl ( HNO ) stimulate soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation? | [
"New therapeutic targets for cardiac hypertrophy, an independent risk factor for heart failure and death, are essential. HNO is a novel redox sibling of NO• attracting considerable attention for the treatment of cardiovascular disorders, eliciting cGMP-dependent vasodilatation yet cGMP-independent positive inotropy... | Our results demonstrate that HNO prevents cardiomyocyte hypertrophy, and that cGMP-dependent NADPH oxidase suppression contributes to these antihypertrophic actions. HNO donors may thus represent innovative pharmacotherapy for cardiac hypertrophy. | yes |
23669411 | Do iDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice? | [
"Indoleamine 2,3 dioxygenase-1 (IDO1) catabolizes tryptophan along the kynurenine pathway. Although IDO1 is expressed in inflamed and neoplastic epithelial cells of the colon, its role in colon tumorigenesis is not well understood. We used genetic and pharmacologic approaches to manipulate IDO1 activity in mice wit... | IDO1, which catabolizes tryptophan, promotes colitis-associated tumorigenesis in mice, independent of its ability to limit T-cell-mediated immune surveillance. The epithelial cell-autonomous survival advantage provided by IDO1 to colon epithelial cells indicate its potential as a therapeutic target. | yes |
26595835 | Does melatonin enhance vertical bone augmentation in rat calvaria secluded spaces? | [
"Melatonin has many roles, including bone remodeling and osseointegration of dental implants. The topical application of melatonin facilitated bone regeneration in bone defects. We evaluated the effects of topical application of melatonin on vertical bone augmentation in rat calvaria secluded spaces.",
"In total,... | Melatonin promoted vertical bone regeneration in rat calvaria in the secluded space within the plastic cap. | yes |
23141857 | Does comorbidity significantly affect clinical outcome after cardiac resynchronization therapy regardless of ventricular remodeling? | [
"The influence of comorbid conditions on ventricular remodeling, functional status, and clinical outcome after cardiac resynchronization therapy (CRT) is insufficiently elucidated.",
"The influence of different comorbid conditions on left ventricular remodeling, improvement in New York Heart Association (NYHA) fu... | Reverse ventricular remodeling and improvement in functional status after CRT implantation are independent from comorbidity burden. However, comorbid conditions remain important predictors of all-cause mortality and heart failure admissions. | yes |
18157310 | Do artificial eye amplitudes and characteristics in enucleated socket with porous polyethylene spherical and quad-motility implant? | [
"To compare artificial eye amplitudes in enucleated socket with porous polyethylene either spherical or quad-motility implant and study the characteristics of artificial eyes fit with the two orbital implants.",
"A total of 21 patients were prospectively studied who underwent enucleation because of an intraocular... | The similar amplitude of movement of artificial eyes was observed with both spherical and quad-motility orbital implants. Artificial eyes fit with quad-motility orbital implant are significantly thicker and heavier than those fit with spherical orbital implant. | yes |
12664077 | Is the metabolic syndrome associated with elevated circulating C-reactive protein in healthy reference range , a systemic low-grade inflammatory state? | [
"To elucidate the underlying mechanisms between C-reactive protein (CRP) and cardiovascular disease, we examined the association of circulating CRP in healthy reference range (< or =1.0 mg/dl) measured by high-sensitive CRP assay with the metabolic syndrome (MS).",
"Cross-sectional study of circulating CRP in adu... | These results indicate that a variety of components of the MS are associated with elevated CRP levels in a systemic low-grade inflammatory state. | yes |
24635080 | Do new intragenic and promoter region deletion mutations in FERMT1 underscore genetic homogeneity in Kindler syndrome? | [
"Kindler syndrome (KS) is a rare autosomal recessive skin disorder, which was recently reclassified as a subtype of epidermolysis bullosa. Despite the fact that loss-of-function mutations in the FERMT1 gene, encoding kindlin-1, have been shown to cause the syndrome in numerous patients, a small number of typical ca... | The present data provide evidence in support of genetic homogeneity in KS. | yes |
26853256 | Does renal sympathetic denervation improve rate control in patients with symptomatic persistent atrial fibrillation and hypertension? | [
"The aim of this study was to investigate whether renal sympathetic denervation (RSD) improves ventricular heart rate (HR) control in patients with persistent atrial fibrillation (AF).",
"Twenty-one patients (aged 57.5 ± 10.2 years, 76.2% male) with persistent AF and hypertension underwent RSD and completed 7-day... | RSD could improve ventricular HR control in patients with persistent AF. RSD slowed AV node conduction in baseline HR-dependent manner. RSD may become an alternative non-pharmaceutical tool for rate control in patients with persistent AF. | yes |
12548606 | Does low expression of p27 indicate a poor prognosis in patients with high-grade astrocytomas? | [
"Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E-dependent kinase (CDK2) by inhibiting the phosphorylation of pRb by CDK2, which, in turn, arrests cells ... | Although p27 and p21 are parallel cell-cycle regulators, only p27 has independent prognostic value in patients with malignant astrocytomas. It appears that decreased levels of p21/p27 are associated with a poor prognosis and short survival. | yes |
26920932 | Does lipoteichoic Acid of Enterococcus faecalis inhibit the Differentiation of Macrophages into Osteoclasts? | [
"Enterococcus faecalis is associated with persistent endodontic infection and refractory apical periodontitis. Recently, we have shown that heat-killed E. faecalis attenuates osteoclast differentiation. Because lipoteichoic acid (LTA) is a major virulence factor of gram-positive bacteria, we investigated the effect... | EfLTA inhibits the differentiation of macrophages into osteoclasts and thereby maintains the phagocytic and inflammatory capacities of macrophages, potentially contributing to refractory apical periodontitis. | yes |
16558612 | Are clinical Experiences Predictive of Outcomes on the NATABOC Examination? | [
"To determine the efficacy of the National Athletic Trainers' Association Board of Certification (NATABOC) clinical experience requirements and individual student characteristics to predict candidate outcomes on the NATABOC certification examination.",
"For all subjects, we gathered survey information and examina... | Gaining clinical experience hours in excess of 400 hours beyond the 800-or 1500-hour requirement may yield no greater benefit for an entry-level professional than less time. The quality, rather than the quantity, of clinical experiences should be evaluated. More emphasis should be placed on the achievement of an entry ... | no |
27377670 | Does echocardiographic left ventricular systolic dysfunction early after resuscitation from cardiac arrest predict mortality or vasopressor requirements? | [
"Echocardiographic abnormalities are common after resuscitation from cardiac arrest. The association between echocardiographic findings with vasopressor requirements and mortality are not well described. We sought to determine the associations between echocardiographic abnormalities and mortality, vasopressor requi... | Echocardiographic parameters (including LVEF) were not associated with inpatient mortality after cardiac arrest. Vasopressor requirements and organ failure severity were not associated with multiple echocardiographic markers of systolic function. | no |
23684818 | Does insulin-degrading enzyme deficiency in bone marrow cells increase atherosclerosis in LDL receptor-deficient mice? | [
"Insulin-degrading enzyme (IDE), a protease implicated in several chronic diseases, associates with the cytoplasmic domain of the macrophage Type A scavenger receptor (SR-A). Our goal was to investigate the effect of IDE deficiency (Ide(-/-)) on diet-induced atherosclerosis in low density lipoprotein-deficient (Ldl... | IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Aβ and RAGE, and higher serum cholesterol in male, Ldlr(-/-) mice. | yes |
25082805 | Does larger A1/M1 diameter ratio predict embolic anterior cerebral artery territorial stroke? | [
"In contrast to middle cerebral artery territory strokes, anterior cerebral artery strokes (ACAS) occur rarely. The low frequency of ACAS, in relation to middle cerebral artery territory strokes, may be explained by differences in ACA and middle cerebral artery anatomy influencing their respective flow-directed emb... | Larger ipsilateral A1 diameters and A1/M1 diameter ratio are associated with embolic ACAS. These findings suggest that A1 diameters and M1 diameters are important in determining the path of emboli that reach the terminal internal carotid artery. | yes |
12828694 | Does regional variation in wound contraction of mohs surgery defect allowed to heal by second intention? | [
"The phenomenon of wound contraction results in a decrease in wound size and a healed scar significantly smaller than the original defect.",
"This study was undertaken (1) to determine the amount of wound contraction in Mohs surgery defects allowed to heal by second intention, (2) to evaluate for regional differe... | Regional differences in wound contraction of secondarily healed head and neck wounds exist and account for some differences in cosmetic acceptability. Scar location, regardless of the degree of wound contraction, is the most important factor for the final cosmetic outcome. | yes |
19755788 | Are serum gamma-glutamyl transferase levels associated with metabolic syndrome in community-dwelling individuals? | [
"Serum gamma-glutamyl transferase (GGT) activity changes in response to oxidative stress. Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Few data are available on the association between serum GGT and the prevalence of MetS among community-dwelling individuals in Japa... | These results suggested that higher serum GGT was significantly associated with MetS and its components in the general population. This association was related with insulin resistance but was independent of other confounding factors. | yes |
24599273 | Is high serum pentosidine but not esRAGE associated with prevalent fractures in type 1 diabetes independent of bone mineral density and glycaemic control? | [
"Fracture risk in type 1 diabetes (T1D) is supposed to be underestimated by bone mineral density (BMD). Individuals with T1D had more prevalent fractures in a cross-sectional study. Serum levels of pentosidine, an advanced glycation end product, and poor glycaemic control were associated with prevalent fractures in... | The pentosidine levels but not BMD are independently associated with prevalent fractures. Impaired bone quality in T1D may result from increased AGE formation. | yes |
21052771 | Do aspects of self differ among physically active and inactive youths? | [
"The aim of this paper was to explore connection between aspects of self and levels of physical activity among adolescents.",
"An international sample of 501 elementary school students (mean age 14.7 ± 0.9 years, 48.5% males) from the Slovak and Czech Republics completed the Self-competence/Self-liking Scale, the... | Regular physical activity is connected with psychological aspects of self among adolescents, especially girls. Incorporating physical activity into the life of youths on a regular basis might lead to the enhancement of their feelings of self-worth and self-efficacy. | yes |
20147743 | Is fGFR4 Arg388 genotype associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer? | [
"A single-nucleotide polymorphism (SNP) in the FGFR4 gene is associated with poor prognosis in solid tumors. A recent study presented the first evidence that FGFR4 Arg388 could predict resistance to adjuvant chemotherapy in breast cancer. The present study evaluates the potential of this SNP to predict response to ... | We provide the evidence that FGFR4 388Arg is an independent predictor of pCR following AC-Doc as NCT in PBC. | yes |
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