id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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20140846 | Is glycaemic control correlated with well-being index ( WHO-5 ) in subjects with type 2 diabetes? | [
"The aim of this study was to examine the potential correlation of WHO-5 well-being index with glycaemic control and chronic complications in subjects with type 2 diabetes. The study included 156 subjects (73 men, mean age 64.05+/-9.11 years, mean diabetes duration 12.22+/-5.61 years). Well-being was assessed by th... | In type 2 diabetic subjects, glycaemic control shows a significant correlation with well-being, while neuropathic pain is associated with lower well-being score. | yes |
22326467 | Does peginterferon-α improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis? | [
"The effect of IFN-α therapy on HBV-specific T-cell responses in HBeAg-negative, genotype D, chronic hepatitis B is largely undefined. Understanding to what extent IFN-α can modulate HBV-specific T-cells is important to define strategies to optimize IFN efficacy and to identify immunological parameters to predict r... | IFN-α did not improve peripheral blood HBV-specific T-cell responses in the first 24 weeks of treatment, consistent either with a predominant antiviral/antiproliferative effect or with an immunomodulatory activity on other arms of the immune system which were not analyzed in our study. A better pre-treatment ex vivo IF... | no |
18842115 | Does mechanical force augment the anti-osteoclastogenic potential of human gingival fibroblasts in vitro? | [
"The cellular response of human gingival fibroblasts to a mechanical force is considered to be primarily anti-osteoclastic because they produce relatively high levels of osteoprotegerin. However, there is little information available on the effects of compression force on the production of osteoprotegerin and osteo... | Application of centrifugal force to human gingival fibroblasts accelerates osteoprotegerin production by these cells, which stimulates the potential of human gingival fibroblasts to suppress osteoclastogenesis. Overall, human gingival fibroblasts might have natural defensive mechanisms to inhibit bone resorption induce... | yes |
16879060 | Is poor prognosis indicated by nucleated red blood cells in peripheral blood associated with organ failure of the liver or kidney? | [
"The appearance of nucleated red blood cells (NRBCs) in peripheral blood is associated with a variety of severe diseases. When NRBCs are detected in blood, this is generally associated with increased mortality.",
"In a prospective study, NRBCs and other laboratory parameters were measured daily in the peripheral ... | The detection of NRBCs in blood of surgical intensive care patients is of prognostic power with regard to patient mortality. This prognostic significance of NRBCs was independent of some clinical and other laboratory risk parameters. The appearance of NRBCs in blood was not associated with kidney failure or lesion of t... | no |
22917751 | Does in utero closure of myelomeningocele improve lower urinary tract function? | [
"Recent data comparing prenatal to postnatal closure of myelomeningocele showed a decreased need for ventriculoperitoneal shunting and improved lower extremity motor outcomes in patients who underwent closure prenatally. A total of 11 children whose spinal defect was closed in utero were followed at our spina bifid... | While in utero closure of myelomeningocele has been shown to decrease rates of ventriculoperitoneal shunting and improve motor function, it is not associated with any significant improvement in lower urinary tract function compared to repair after birth. | no |
23838742 | Does elective resection for ongoing diverticular disease significantly improve quality of life? | [
"Although the risks of elective resection for diverticular disease are well studied, studies on subjective improvement are scarce. This study aims to investigate subjective improvement.",
"All patients who underwent elective resection for recurring or persisting complaints after an episode of diverticulitis were ... | Elective resection of the sigmoid for persisting or recurring symptoms after an episode of diverticulitis improves general QoL and discomfort caused by abdominal pain, abnormal defecation and fatigue in the vast majority of patients. | yes |
20027663 | Do p53 Levels positively correlate with carotid intima-media thickness in patients with subclinical atherosclerosis? | [
"The level of circulating p53 is related to inflammation in asymptomatic subjects with cardiovascular risk factors. Whether p53 is associated with the severity of atherosclerosis remains to be determined.",
"This study examines the relationship of systemic p53 levels with atherosclerotic risk factors and subclini... | Higher plasma p53 levels were associated with an increase in inflammatory markers, as well as increased carotid IMT. Circulating p53 may be useful in identifying subclinical atherosclerosis in subjects symptomatically free from cardiovascular disease. | yes |
25750528 | Does hyperprolactinemia during antipsychotics treatment increase the level of coagulation markers? | [
"The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolac... | The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE. | yes |
26155169 | Is vitamin D deficiency related to thyroid antibodies in autoimmune thyroiditis? | [
"It has been known that vitamin D has some immunomodulatory effects and in autoimmune thyroid diseases, vitamin D deficiency was more prevalent. In this study, our aim was to investigate the relationship between thyroid autoantibodies and vitamin D.",
"Group 1 and 2 consisted of 254 and 27 newly diagnosed Hashimo... | In this study, we found that patients with autoimmune thyroid disease (AITD) present with lower vitamin D levels and GD patients have higher prevalence. Since we found an inverse correlation between vitamin D levels and thyroid antibody levels, we may suggest that vitamin D deficiency is one of the potential factors in... | yes |
21527197 | Does management of the urinary tract in spina bifida cases vary with lesion level and shunt presence? | [
"The urinary and gastrointestinal tracts remain an enormous burden to the patient with spinal dysraphism. We examined our cases to determine the relationship between the level and type of spinal dysraphism, presence of a ventricular shunt, and urinary and gastrointestinal tract management.",
"After receiving ethi... | Our data confirm the association of lesion level, a ventricular shunt and continence. | yes |
23644008 | Are parenteral nutrition mixtures prepared at home by trained parents as safe as pharmacy-made mixtures : a 3-y prospective study? | [
"Home parenteral nutrition (HPN) prevents malnutrition in children with intestinal failure improving chances for the best possible physical development and quality of life. For organizational reasons, in Poland the majority of children on HPN receive nutrition mixtures prepared at home by their parents. The aim of ... | Preparing parenteral nutrition mixtures at home by trained parents is a safe method of HPN with a slightly (however insignificantly) lower incidence of CRBSIs compared with hospital pharmacy-prepared parenteral nutrition mixtures. | yes |
23900220 | Does prognostic implication of the CpG island methylator phenotype in colorectal cancers depend on tumour location? | [
"Colorectal cancer (CRC) is usually categorised as proximal or distal CRC. Recently, many researchers have tried to determine the molecular heterogeneity of CRCs along bowel subsites. However, the differential effects of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the clinical... | Clinicopathologic and molecular profiles of CRCs gradually change along bowel subsites, and the prognostic implication of CIMP is different according to tumour location. | yes |
19228085 | Does a prediction model for chronic kidney disease include periodontal disease? | [
"An estimated 75% of the seven million Americans with moderate-to-severe chronic kidney disease are undiagnosed. Improved prediction models to identify high-risk subgroups for chronic kidney disease enhance the ability of health care providers to prevent or delay serious sequelae, including kidney failure, cardiova... | This United States population-based study suggested the importance of considering multiple risk factors, including periodontal status, because this improves the identification of individuals at high risk for chronic kidney disease and may ultimately reduce its burden. | yes |
24986419 | Does gRACE score predict heart failure admission following acute coronary syndrome? | [
"Congestive heart failure (CHF) is a common and preventable complication of acute coronary syndrome (ACS). Nevertheless, ACS risk scores have not been shown to predict CHF risk. We investigated whether the at-discharge Global Registry of Acute Coronary Events (GRACE) score predicts heart failure admission following... | The GRACE score predicts CHF admission, and may therefore be used to target ACS patients at high risk of CHF with clinical monitoring and therapies. | yes |
25651307 | Does early Posttransplant Tryptophan Metabolism predict Long-term Outcome of Human Kidney Transplantation? | [
"Chronic transplant dysfunction (CTD) is the leading cause of long-term loss of the renal allograft. So far, no single test is available to reliably predict the risk for CTD. Monitoring of tryptophan (trp) metabolism through indoleamine 2.3-dioxygenase (IDO) has been previously proposed to predict acute rejection o... | Early serum and urine levels of trp and kyn may offer a novel route for early detection of patients at risk for developing CTD. | yes |
24389400 | Does citicoline ( CDP-choline ) protect myocardium from ischemia/reperfusion injury via inhibiting mitochondrial permeability transition? | [
"Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas... | This work introduces CDP-choline as a useful tool to preserve heart function from reperfusion damage by inhibiting mitochondrial permeability transition. | yes |
22913774 | Does exendin-4 protect murine pancreatic β-cells from free fatty acid-induced apoptosis through PI-3K signaling? | [
"Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by the L-cells of the distal intestine that has proliferative and anti-apoptotic actions on the β-cell.",
"In this study, exendin-4, a long-acting GLP-1 receptor agonist, was studied as a novel agent to suppress apoptosis in pancreatic β-cells and t... | These results suggest that phosphoinositide-3 kinase signaling is involved in the modulation of β-cell apoptosis which is induced by exendin-4. Taken together, our findings provide a new mechanism for the modulation of exendin-4 in the pathological processes underlying FFA-induced diabetes mellitus. | yes |
16095448 | Are bispectral Index values higher during halothane vs. sevoflurane anesthesia in children , but not in infants? | [
"Previously, we have shown in adult patients that bispectral index score (BIS) values are significantly higher during halothane anesthesia (53-61 units) as compared with those observed during equipotent concentrations of sevoflurane (39-43 units). Because halothane is frequently used in the pediatric setting, we te... | These findings suggest that BIS values are higher during halothane vs. sevoflurane anesthesia in children, but not in infants. | yes |
21080833 | Is amniotic membrane an immunosuppressor of peripheral blood mononuclear cells? | [
"Amniotic membrane (AM) is the inner layer of the placenta, which is in contact with the fetus; it has been used for transplantation in ocular surface diseases. It has been reported that amniotic membrane promotes epithelialization, inhibits angiogenesis and diminishes ocular inflammation. A persistent epithelial d... | Taken together, these results could explain the anti-inflammatory in vivo effects observed when the amniotic membrane is used as a transplant. | yes |
23903009 | Does absence of FcγRIII result in increased proinflammatory response in FcγRIII-KO cardiac recipients? | [
"Alloantibody can contribute significantly to rejection of heart transplants by activation of complement and interactions with a variety of effector cells, including macrophages and monocytes through activating FcγRI, FcγRIII, FcγRIV, the inhibitory FcγRIIB and complement receptors. These receptors link cellular an... | We propose that absence of FcγRIII is associated with the lack of efficient SAP-mediated clearance of apoptotic cells through FcγRs. Apoptotic cells become immunogenic and induce enhanced inflammation, alloantibody production, and complement activation leading to accelerated cardiac allograft rejection. | yes |
19718443 | Do serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis? | [
"There is a need for biomarkers insuring identification of septic patients at high-risk for death. We performed a prospective, multicenter, observational study to investigate the time-course of lipopolysaccharide binding protein (LBP) serum levels in patients with severe sepsis and examined whether serial serum lev... | Serial LBP serum measurements may offer a clinically useful biomarker for identification of patients with severe sepsis having the worst outcomes and the highest probability of developing sepsis-induced ARDS. | yes |
18722616 | Are progesterone receptor gene polymorphisms associated with preterm birth in a Hispanic population? | [
"To determine whether increased frequency of mutant alleles of the progesterone receptor gene (PGR) was associated with preterm birth in a population of Hispanic women.",
"Placental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by ... | The present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population. | no |
17417605 | Do ca2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease? | [
"Choroidal neovascularization (CNV) is the most severe complication in age-related macular degeneration. The major angiogenic factor involved is vascular endothelial growth factor (VEGF) secreted by the retinal pigment epithelium (RPE). Since RPE cells express neuroendocrine L-type Ca2+ channels we investigated the... | Thus, L-type Ca2+ channels in normal RPE cells regulate the secretion of VEGF. RPE cells from eyes with CNV maintain a VEGF secretion regulated by nifedipine-sensitve Ca2+ channels which might be of importance for the development of CNV. | yes |
22539964 | Is ets-1 essential for connective tissue growth factor ( CTGF/CCN2 ) induction by TGF-β1 in osteoblasts? | [
"Ets-1 controls osteoblast differentiation and bone development; however, its downstream mechanism of action in osteoblasts remains largely undetermined. CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function. CCN2 is induced by TGF-β1 and acts as a mediator of TGF-β1 induced mat... | This study demonstrates that Ets-1 is an essential downstream signaling component for CCN2 induction by TGF-β1 in osteoblasts, and that specific EBE sites in the CCN2 promoter are required for CCN2 promoter transactivation in osteoblasts. | yes |
23446746 | Do damage to pig bile duct caused by intraluminal brachytherapy using a ( 125 ) I ribbon? | [
"Stent occlusion by tumor ingrowth or overgrowth is the main cause of jaundice recurrence after metal stent insertion in patients with malignant obstructive jaundice (MOJ). The application of intraluminal brachytherapy (ILBT) in patients with MOJ results in local control of malignant tumors, which prolong stent pat... | This study demonstrated the safety of ILBT using a (125)I ribbon in the pig bile duct. (125)I seed ribbons may be used in the treatment of MOJ in humans. | yes |
17004019 | Is patient-centred advice effective in improving adherence to medicines? | [
"To assess the effects of pharmacists giving advice to meet patients' needs after starting a new medicine for a chronic condition.",
"A prospective health technology assessment including a randomised controlled trial of a pharmacist-delivered intervention to improve adherence using a centralised telephone service... | Overall, these findings show benefits from pharmacists meeting patients' needs for information and advice on medicines, soon after starting treatment. While a substantially larger trial would be needed to confirm that the effect is real and sustained, these initial findings suggest the service may be safe and useful to... | yes |
17083376 | Are human polymorphonuclear leukocytes sensitive in vitro to Helicobacter pylori vaca toxin? | [
"Interactions between bacterial components and polymorphonuclear leukocytes (PMNL) play a major pathogenic role in Helicobacter pylori-associated diseases. Activation of PMNL can be induced by contact with whole bacteria or by different H. pylori products released in the extracellular space either by active secreti... | Taken together, these data showed that human PMNL is a sensitive cell population to H. pylori VacA toxin. However, activation of PMNL (i.e., oxidative burst, phagocytosis, CD11b up-regulation) and PMNL apoptosis are not affected by VacA, raising question about the role of VacA toxin on PMNL in vivo. | yes |
24858338 | Does vascular neuropeptide Y contribute to atherosclerotic plaque progression and perivascular mast cell activation? | [
"Neuropeptide Y is an abundantly expressed neurotransmitter capable of modulating both immune and metabolic responses related to the development of atherosclerosis. NPY receptors are expressed by a number of vascular wall cell types, among which mast cells. However, the direct effects of NPY on atherosclerotic plaq... | Our data show that NPY expression is increased during atherogenesis and in particular in unstable plaques. Furthermore, perivascular overexpression of NPY promoted plaque development and perivascular mast cell activation, suggestive of a role for NPY-induced mast cell activation in lesion progression. | yes |
25890327 | Does rNA sequencing reveal distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells? | [
"Microglial cells become rapidly activated through interaction with pathogens, and their persistent activation is associated with the production and secretion of various pro-inflammatory genes, cytokines, and chemokines, which may initiate or amplify neurodegenerative diseases. Bromodomain and extraterminal domain ... | These unprecedented results suggest the BET inhibitor JQ1 as a candidate for the prevention or therapeutic treatment of inflammation-mediated neurodegenerative diseases. | yes |
19632207 | Does coenzyme Q10 supplementation lower hepatic oxidative stress and inflammation associated with diet-induced obesity in mice? | [
"Diabetes and obesity are metabolic disorders induced by an excessive dietary intake of fat, usually related to inflammation and oxidative stress.",
"The aim of the study is to investigate the effect of the antioxidant coenzyme Q10 (CoQ10) on hepatic metabolic and inflammatory disorders associated with diet-induc... | In conclusion, HFF model promotes glucose intolerance and obesity by a mechanism independent on the level of tissue peroxides. CoQ10 tends to decrease hepatic stress gene expression, independently of any modulation of lipid peroxidation, which is classically considered as its most relevant effect. | yes |
19729148 | Do [ Study of a case of cochlear implant with recurrent cutaneous extrusion ]? | [
"An observation of a difficult-to-diagnose complication of the cochlear implant: recurring cutaneous extrusion of a cochlear implant is reported.",
"The history of an adult patient with total deafness is reported. She received an implant in her right ear in 1988, which was then explanted because of absence of hea... | Cutaneous complications after cochlear implant are exceptional. As soon as cutaneous disorders appear, a rigorous diagnostic process must be followed so that the patient can be recommended a long-lasting solution to restore quality hearing. | yes |
20735392 | Does epstein-Barr virus DNA load in tumour tissues correlate with poor differentiation status in non-muscle invasive urothelial carcinomas? | [
"To detect the correlation between the clinical staging, grading and genomic Epstein-Barr virus (EBV) viral numbers in tumour tissues of urothelial carcinoma patients.",
"From June 2004 to May 2008, 60 urothelial carcinoma patients (50 cases of bladder carcinoma and 10 of upper tract urothelial carcinoma (UTUC) w... | Epstein-Barr virus DNA could be detected in the genome of the urothelial carcinoma specimens. The poor differentiation status was correlated with the high load of the EBV genome in non-muscle invasive urothelial carcinoma. However, recurrence-free survival was not greater in EBV-positive patients than in EBV-negative p... | yes |
27638620 | Does aMPKα2 regulate Bladder Cancer Growth through SKP2-Mediated Degradation of p27? | [
"AMP-activated protein kinase (AMPK) is the central metabolic regulator of the cell and controls energy consumption based upon nutrient availability. Due to its role in energy regulation, AMPK has been implicated as a barrier for cancer progression and is suppressed in multiple cancers. To examine whether AMPK regu... | These results highlight the contribution of AMPKα2 as a mechanism for controlling bladder cancer growth by regulating proliferation through mTOR suppression and induction of p27 protein levels, thus indicating how AMPKα2 loss may contribute to tumorigenesis. Mol Cancer Res; 14(12); 1182-94. ©2016 AACR. | yes |
22216231 | Does catechol-O-methyltransferase Val158Met polymorphism associate with individual differences in sleep physiologic responses to chronic sleep loss? | [
"The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel ma... | The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight fo... | yes |
16897282 | Does thoracoscopic and laparoscopic oesophagectomy improve the quality of extended lymphadenectomy? | [
"Oesophagectomy with extended lymphadenectomy carries considerable morbidity due to parietal trauma. It is also technically extremely demanding because the difficult access even through a large thoracotomy requires the use of long instruments to reach the deepest recess in the chest cavity. Since the first thoracos... | Thoracoscopic and laparoscopic oesophagectomy with extended lymphadenectomy is technically feasible and safe. Thoracoscopic oesophagectomy in prone position improves the quality of dissection because: The oesophagus and aorto-pulmonary window are reached under excellent visibility, despite a partially deflated lung, wh... | yes |
14739611 | Does apoptosis participate to liver damage in HSV-induced fulminant hepatitis? | [
"HSV fulminant hepatitis is a rare pathology. Rapid hepatic failure, as a consequence of extended liver damage, has generally been attributed to necrosis. As apoptosis can constitute another way for hepatocytes to die, we decided to investigate whether programmed cell death took place during HSV fulminant hepatitis... | These data as a whole show that apoptosis is responsible, at least partially, for liver damage during HSV fulminant hepatitis. | yes |
17070550 | Does tIMP-2 modulate neointimal formation in experimental ePTFE arterial grafts? | [
"In vascular reconstructive surgery, myointimal hyperplasia contributes to the adverse outcome of synthetic grafts. This phenomenon is because of unregulated extracellular matrix degradation and remodeling, and excessive smooth muscle cell proliferation and migration. Matrix metallopreoteinase 2 (MMP-2) is known as... | Use of TIMP-2 affects the neointimal formation of experimental e-PTFE arterial grafts, leading to a better-organized neointima, with improved endothelialization. | yes |
18329019 | Does unilateral subthalamic nucleus stimulation have a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease? | [
"Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS.",
"In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (n=42), ... | Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS. | yes |
19452200 | Do mechanical and biological evaluations of beta-tricalcium phosphate/silicone rubber composite as a novel soft-tissue implant? | [
"Although silicone rubber (SR) implants are most commonly used and effective for soft-tissue augmentation, they still have been implicated in many adverse reactions. To overcome this problem, a novel composite beta-tricalcium phosphate/silicone rubber (beta-TCP/SR) was prepared by adding beta-TCP into a SR matrix. ... | Although some mechanical properties were significantly changed, the results of the cytocompatibility test and in vivo animal study still suggest that beta-TCP/SR may be more suitable as a soft-tissue implant than SR and has the potential to be used in plastic surgery. | yes |
9536966 | Is thrombospondin-1 elevated with both intimal hyperplasia and hypercholesterolemia? | [
"Thrombospondin-1 (TSP-1) is important in platelet adhesion and aggregation, inflammation, cell to cell interaction, angiogenesis, and smooth muscle cell (SMC) proliferation. TSP-1 expression increases rapidly with injury. Therefore, we hypothesize that TSP-1 may play a role in the development of intimal hyperplasi... | These data are consistent with the hypothesis that TSP-1 contributes to the development of IH. This study suggests that injured arteries in hypercholesterolemic atherosclerotic rabbits overexpress TSP-1. | yes |
11683968 | Do urinary transforming growth factor-beta1 levels correlate with bladder outlet obstruction? | [
"Urinary transforming growth factor-beta1 (TGF-beta1) levels have been shown to correlate with elevated intrapelvic pressure associated with ureteropelvic junction obstruction. Other studies have evaluated urinary TGF-beta1 levels in prostate cancer. This study tests the hypothesis that urinary TGF-beta1 levels mig... | Urinary TGF-beta1 levels correlate with objective measures of BOO. Further study is needed to test the utility of urinary TGF-beta1 as a non-invasive diagnostic tool for BOO. | yes |
7851587 | Does elevated luteinizing hormone on the day of human chorionic gonadotropin administration reduce cycle fecundity in a low-dose flare-up in vitro fertilization protocol? | [
"To determine if elevated LH at the time of hCG administration occurs and adversely affects success in a low-dose gonadotropin-releasing hormone analogue (GnRH-a) flare-up protocol in hMG-stimulated IVF cycles.",
"Pearson correlation matrix analysis of hormonal, gamete, and clinical data derived from 203 consecut... | In a low-dose, GnRH-suppression, IVF induction protocol, elevated LH occurs in a small subset (13%) of women at the time of hCG administration. This event does not appear to alter cycle fecundity nor induce premature luteinization. | no |
25000249 | Is radial primary percutaneous coronary intervention independently associated with decreased long-term mortality in high-risk ST-elevation myocardial infarction patients? | [
"To compare long-term clinical outcomes in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI) using radial and femoral arterial access.",
"The present study was an observational cohort study of patients with STEMI treated consecutively with PPCI b... | Patients undergoing PPCI via the femoral route are at a higher risk of adverse short-term and long-term outcomes than patients undergoing PPCI via the radial route. Patients with a high baseline risk may benefit most from radial access, and future outcome studies should focus on the most at-risk patients. | yes |
23213272 | Is nectin-1-specific entry of herpes simplex virus 1 sufficient for infection of the cornea and viral spread to the trigeminal ganglia? | [
"Primary and recurrent infections of the cornea by herpes simplex virus 1 (HSV-1) are important causes of eye disease. Three unrelated classes of glycoprotein D receptors for HSV-1 entry into cells have been identified. This study was undertaken to uncover the relative significance of nectin-1 as an entry receptor ... | Our findings suggest that nectin-1 alone is sufficient for HSV-1 entry into the cornea and spread to the TG. | yes |
18035058 | Is maternal chronic hepatitis B virus implicated with low neonatal paraoxonase/arylesterase activities? | [
"Paraoxonase/arylesterase activities are closely implicated with liver function and antiatherogenetic process.",
"To evaluate whether maternal chronic hepatitis B virus, disease (HBV) affect serum neonatal paraoxonase/arylesterase activities.",
"28 pregnant women with HBV and 28 healthy pregnant women (controls... | Decreased PON 1 and PON-aryl activities were measured in infants born from hepatic mothers probably as a consequence of their low TAC. Infants born from HBV mothers are at risk for developing LDL oxidation perinatally. | yes |
20602768 | Does hind limb unloading of mice modulate gene expression at the protein and mRNA level in mesenchymal bone cells? | [
"We investigated the extent, modalities and reversibility of changes at cellular level in the expression of genes and proteins occurring upon Hind limb unloading (HU) in the tibiae of young C57BL/6J male mice. We focused on the effects of HU in chondrogenic, osteogenic, and marrow mesenchymal cells.",
"We analyze... | HU induces the coordinated modulation of gene expression in different mesenchymal cell types and microenvironments of tibia. HU also induces specific patterns of expression for homeostasis related genes and modulation of mRNAs and proteins for ECM deposition, maturation and remodeling which may be key factors for bone ... | yes |
16159974 | Does pulmonary artery growth fail to match the increase in body surface area after the Fontan operation? | [
"To evaluate the growth of the pulmonary arteries after a Fontan procedure.",
"Retrospective review.",
"Two paediatric cardiology tertiary care centres.",
"61 children who underwent a modified Fontan operation and had angiography suitable for assessment of pulmonary artery size before the Fontan procedure and... | After the Fontan operation, growth of the pulmonary arteries often fails to match the increase in body surface area. | yes |
19100393 | Does high serum level of the soluble CD30 identify Chinese kidney transplant recipients at high risk of unfavorable outcome? | [
"We sought to investigate the relationship between serum level of sCD30 and recipient/graft survival rates, rejection types, as well as other prognostic factors among Chinese kidney transplant patients.",
"We performed enzyme-linked immunosorbent assays of serum sCD30 levels in duplicate among retrospective cohor... | Pretransplant sCD30 serum levels reflect immune status. | yes |
22075248 | Does transsignaling of interleukin-6 crucially contribute to atherosclerosis in mice? | [
"Transsignaling of interleukin (IL)-6 is a central pathway in the pathogenesis of disorders associated with chronic inflammation, such as Crohn disease, rheumatoid arthritis, and inflammatory colon cancer. Notably, IL-6 also represents an independent risk factor for coronary artery disease (CAD) in humans and is cr... | These data clarify, for the first time, the critical involvement of, in particular, the transsignaling of IL-6 in CAD and warrant further investigation of sgp130Fc as a novel therapeutic for the treatment of CAD and related diseases. | yes |
24528994 | Does a genome-wide study of de novo deletions identify a candidate locus for non-syndromic isolated cleft lip/palate risk? | [
"Copy number variants (CNVs) may play an important part in the development of common birth defects such as oral clefts, and individual patients with multiple birth defects (including clefts) have been shown to carry small and large chromosomal deletions. In this paper we investigate de novo deletions defined as DNA... | This study presents a region where de novo deletions appear to be involved in the etiology of oral clefts, although the underlying biological mechanisms are still unknown. Larger de novo deletions are more likely to interfere with normal craniofacial development and may result in more severe clefts. Study protocol and ... | yes |
24685353 | Does neuromyelitis optica MOG-IgG cause reversible lesions in mouse brain? | [
"Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) are present in some neuromyelitis optica patients who lack antibodies against aquaporin-4 (AQP4-IgG). The effects of neuromyelitis optica MOG-IgG in the central nervous system have not been investigated in vivo. We microinjected MOG-IgG, obtained fro... | These differences mirror the better outcomes for MOG-IgG compared with AQP4-IgG patients and raise the possibility that MOG-IgG contributes to pathology in some neuromyelitis optica patients. | yes |
22183029 | Does alternative glycosylation modulate function of IgG and other proteins - implications on evolution and disease? | [
"Nearly all membrane and secreted proteins, as well as numerous intracellular proteins are glycosylated. However, contrary to proteins which are defined by their individual genetic templates, glycans are encoded in a complex dynamic network of hundreds of genes which participate in the complex biosynthetic pathway ... | Numerous proteins depend on correct glycosylation for proper function. Very good example for this is the alternative glycosylation of IgG whose effector functions can be completely changed by the addition or removal of a single monosaccharide residue from its glycans. | yes |
25559145 | Does notch ligand Delta-like 1 promote in vivo vasculogenesis in human cord blood-derived endothelial colony forming cells? | [
"Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability. Because Notch signaling is critical for embryonic blood vessel formation in utero, we hypothesized that Notch pathway activation may enhance cultur... | We conclude that Notch pathway activation in ECFC in vivo via co-implanted stromal cells expressing delta-like 1 promotes vasculogenesis and augments blood vessel formation via diminishing apoptosis of the implanted ECFC. | yes |
7963111 | Is optimal use of directional coronary atherectomy required to ensure long-term angiographic benefit : a study with matched procedural outcome after atherectomy and angioplasty? | [
"This study was designed to examine whether restenosis is related to the extent or mechanism of lumen improvement and to explore angiographic determinants of optimal atherectomy.",
"Directional atherectomy induces a greater extent of immediate gain and late loss but has not been found to yield a better late angio... | Restenosis is a consequence not only of the extent of lumen improvement but also of the mechanism of vessel wall injury (debulking vs. dilating). While performing atherectomy, the operator should strive for an optimal procedural result to accommodate an increased intimal hyperplastic response. | yes |
18475221 | Do control of cardiovascular risk factors and use of aspirin in diabetic patients remain elusive? | [
"Type 2 diabetics are at higher risk for cardiovascular disease. To reduce this risk, the American Diabetes Association recommends traditional cardiovascular disease risk factor modification, reducing hemoglobin A1c (HbA1c), and the use of aspirin for patients over 30 years of age. The goal of this study was to ana... | Optimal cardiovascular risk modification was achieved in less than 50% of type 2 diabetics. Aspirin remains underused for primary prevention. These results highlight the continued difficulties in achieving control of diabetes to the extent recommended by American Diabetes Association guidelines. | yes |
20864661 | Is severity of dilated Virchow-Robin spaces associated with age , blood pressure , and MRI markers of small vessel disease : a population-based study? | [
"Little is known about the risk factors of dilated Virchow-Robin spaces (dVRS) and their relation with other markers of brain small vessel disease. We investigated both issues in a large population-based sample of elderly individuals.",
"Severity of dVRS was semiquantitatively graded in both white matter and basa... | In this large cohort study of elderly subjects, the degree of dVRS appears independently associated with age, hypertension, volume of white matter hyperintensities, and lacunar infarctions. dVRS should be considered as another MRI marker of cerebral small vessel disease in the elderly with regional variations in their ... | yes |
16352244 | Does spinal cord stimulation significantly improve refractory angina pectoris-a local experience spinal cord stimulation in refractory angina? | [
"Severe refractory angina pectoris can occur in end-stage coronary artery disease despite maximal medical and revascularization therapy. Spinal cord stimulation is an under-utilized but well-established modality for the treatment of intractable angina pain.",
"To illustrate the practical, beneficial and effective... | Spinal cord stimulation is an effective medium-term treatment option for refractory angina pectoris with significant benefits to functional parameters and patient symptoms. Spinal cord stimulation is an under-utilized but well-established modality for the treatment of intractable angina pain. We report a small case ser... | yes |
19587603 | Is habitual physical activity associated with endothelial function and endothelial progenitor cells in patients with stable coronary artery disease? | [
"Exercise training reduces mortality in patients with coronary artery disease (CAD); however, the impact of habitual physical activity level (PAL) on vascular endothelial function and circulating endothelial progenitor cells (EPCs) remain unknown.",
"We assessed habitual PAL using a validated International Physic... | This study showed that higher habitual PAL in patients with CAD was associated with higher FMD and EPC count. Nonetheless, FMD only significantly correlated with increased PAL, but not EPC, suggesting that increased physical activity improves endothelial function through mechanisms other than increasing EPC count. | yes |
22548745 | Does spatiotemporal network motif reveal the biological traits of developmental gene regulatory networks in Drosophila melanogaster? | [
"Network motifs provided a \"conceptual tool\" for understanding the functional principles of biological networks, but such motifs have primarily been used to consider static network structures. Static networks, however, cannot be used to reveal time- and region-specific traits of biological systems. To overcome th... | Taken together, the proposed concept and the simulations can be used to unravel the design principle of developmental gene regulatory networks. | yes |
24662518 | Are cerebral oximetry levels during CPR associated with return of spontaneous circulation following cardiac arrest : an observational study? | [
"Cerebral oximetry using near-infrared spectroscopy measures regional cerebral oxygen saturation (rSO2) non-invasively and may provide information regarding the quality of cerebral oxygen perfusion. We determined whether the level of rSO2 obtained during cardiopulmonary resuscitation is associated with return of sp... | In ED patients with cardiac arrest higher cerebral oxygen saturations are associated with higher rates of ROSC. | yes |
25765160 | Does association of peripheral total and differential leukocyte count with obesity-related complications in young adults? | [
"Obesity has been demonstrated to be associated with elevated leukocytes in adults and children. This study assessed the associations between peripheral total and differential leukocyte counts and obesity-related complications in young adults.",
"12 obese (median age 21.5 (range 19-28) years, median BMI 35.7 (ran... | The results of this study suggest that chronic low-grade systemic inflammation is associated with obesity-related complications such as nonalcoholic fatty liver disease, insulin resistance, and dyslipidemia in young adults. | yes |
27160188 | Does exploring miRNAs involved in blue/UV-A light response in Brassica rapa reveal special regulatory mode during seedling development? | [
"Growth, development, and pigment synthesis in Brassica rapa subsp. rapa cv. Tsuda, a popular vegetable crop, are influenced by light. Although microRNAs (miRNAs) have vital roles in the metabolic processes and abiotic stress responses of plants, whether miRNAs play a role in anthocyanin biosynthesis and developmen... | A set of miRNAs and their targets involved in the regulation of the light-induced photomorphogenic phenotype in seedlings of Brassica rapa was identified, providing new insights into blue and UV-A light-responsive miRNAs in seedlings of Tsuda and evidence of multiple targets for the miRNAs and their diverse roles in pl... | yes |
8522675 | Does flow-triggering reduce inspiratory effort during weaning from mechanical ventilation? | [
"To investigate whether a new flow-triggered (FT) system can reduce the patient's inspiratory effort compared to a traditional pressure-triggered (PT) system during weaning from mechanical ventilation.",
"Prospective study.",
"Intensive care unit of a General Hospital.",
"10 mechanically ventilated patients, ... | The new FT system, i.e. flow-by system, reduces the unintentional ventilatory workload upon the patients' inspiratory muscles compared to traditional PT system during weaning from mechanical ventilation. | yes |
15535926 | Does [ Atorvastatin lower C-reactive protein in dislipemic patients with type 2 diabetes mellitus ]? | [
"Type 2 diabetes mellitus is associated with an augmented risk for cardiovascular disease. The levels of C-reactive protein (CRP), the prototypic marker of inflammation, are associated with an increased risk for cardiovascular events. The statins have direct anti-inflammatory effects. Thus, we tested the effects of... | These results confirm findings from previous studies that atorvastatin reduce CRP levels in a largely LDL cholesterol independent manner. | yes |
11031699 | Does a corticotropin releasing hormone receptor antagonist delay parturition in rats? | [
"To determine the effects of CP-154, 526, a corticotropin releasing hormone (CRH) receptor antagonist, on the length of normal rat gestation.",
"Twenty-four timed-pregnant Sprague-Dawley rats were purchased for this study. The drug and placebo were administered to the animals using an osmotic pump surgically inse... | Antagonism of CRH receptors in rats has no effect on the length of gestational period, pup weight or number of pups per litter. Further studies are needed to define the role of CRH and its antagonism in primate pregnancy, as has been done in sheep. | no |
23052539 | Does frailty predict outcome of elective laparoscopic cholecystectomy in geriatric patients? | [
"Frailty is a phenotype characterized by complex and challenging medical problems and higher susceptibility to adverse health outcomes. It can be derived at by a multidimensional process known as comprehensive geriatric assessment (CGA), which assesses the functional reserves of the elderly. In this study we report... | Preoperative CGA may predict postoperative complications and prolonged postoperative hospital stay of elderly patients who undergo elective laparoscopic cholecystectomy. Larger-scale studies independently assessing this association are warranted. | yes |
7585835 | Does inhibition of nitric oxide synthesis protect the isolated working rabbit heart from ischaemia-reperfusion injury? | [
"Nitric oxide (NO) exerts both protective and detrimental actions in a variety of biological systems. During acute reperfusion following myocardial ischaemia, a rapid overproduction of free radicals, including NO, may occur. We investigated the effects of the NO synthase inhibitors NG-nitro-L-arginine methyl ester ... | These results suggest that: (1) the recovery of mechanical function of hearts subjected to ischaemia-reperfusion injury can be improved by modulation of myocardial NO synthesis, (2) inhibition of NO synthesis (with L-NAME or L-NMMA) may offer prolonged protection whereas its stimulation (with L-arginine) provides only ... | yes |
16802400 | Is fatty acid-induced effect on glucagon secretion mediated via fatty acid oxidation? | [
"While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta cells has been well-defined, only limited information is available on alpha cells. This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation.",
"Clonal alpha... | Our data indicates that compared with triglyceride accumulation, glucagon secretion is more sensitive to changes in fatty acid concentration. The effect of fatty acids on the glucagon response is mediated through their oxidation. The high carnitine palmitoyl transferase-1 gene expression and the accumulation of triglyc... | yes |
17722861 | Is the distribution of interstitial cells of Cajal in the ileum altered by infection with Schistosoma mansoni? | [
"The interstitial cells of Cajal (ICC) act as pacemakers that generate slow waves and function as a relay between smooth muscle cells of the gastrointestinal (GI) tract. Recent reports indicate the crucial role played by the ICC in defining GI motility during human disease status like pyloric stenosis, Hirschsprung... | No disappearance of either ICC population was noted. A preferential (although not exclusive) location of inflammatory infiltrate in contact with SK3-ir FLC in the muscle layer was observed. The present study thus delineated that ICC are not affected during S. mansoni infections, and thereby may not be responsible for m... | no |
26104216 | Is predictors of blood pressure response : Obesity associated with a less pronounced treatment response after renal denervation? | [
"The purpose of this study was to identify predictors of BP response.",
"Catheter-based renal denervation (RDN) causes significant blood pressure (BP) reductions in a large number of patients with resistant hypertension.",
"One hundred one consecutive patients with resistant hypertension who underwent RDN with ... | Blood pressure reductions after RDN were more pronounced in patients with higher baseline blood pressure and lower BMI. These findings may have implications regarding patient selection for renal denervation. © 2015 Wiley Periodicals, Inc. | yes |
23704928 | Do farmed areas predict the distribution of amphibian ponds in a traditional rural landscape? | [
"Traditional rural landscapes of Eastern Europe are undergoing major changes due to agricultural intensification, land abandonment, change in agricultural practices and infrastructural development. Small man-made ponds are important yet vulnerable components of rural landscapes. Despite their important role for bio... | Our Maxent models revealed that the highest probability of occurrence for amphibian ponds was in areas used as farmland. The traditional farming practices combined with a low level of infrastructure development produces a large number of amphibian ponds. The challenge is to harmonize economic development and the mainte... | yes |
9400483 | Does constant elevation in renal pelvic pressure induce an increase in urinary N-acetyl-beta-D-glucosaminidase in a nonobstructive porcine model? | [
"To clarify the physiological significance of renal pelvic pressure elevations encountered in the evaluation of hydronephrotic kidney we examined the effects of different levels of renal pelvic pressure on the induction of renal injury.",
"A nonobstructive porcine model was created in which the urine drained agai... | Excessively high collecting system pressure induced renal cellular injury, as reflected by an increase in urinary N-acetyl-beta-D-glucosaminidase levels. While renal pelvic pressure up to 10 cm. water appeared to be innocuous, renal cellular injury was evident within as little as 1 hour at renal pelvic pressures 20 cm.... | yes |
26542462 | Does p38 MAPK mediate glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons? | [
"We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrapped neuronal somata, resulting in down-regulation of P2X3Rs. This P2X7R-P2Y1-P2X3R inhibitory control sign... | p38 in DRG neurons downstream of P2Y1R is necessary and sufficient for the P2X7R-P2Y1R inhibitory control of P2X3R expression. | yes |
19661232 | Do topical mydriatics affect light-evoked retinal responses in anesthetized mice? | [
"To characterize effects of the muscarinic antagonist atropine (A) and the alpha-adrenergic agonist, phenylephrine (P), on mydriasis and light-evoked signaling in mice anesthetized by ketamine and xylazine (K+X).",
"Pupillary areas of anesthetized C57BL/6 mice were measured, with or without topical application of... | Topical administration of A and P together, but not separately, in the presence of K+X, leads to a slow, dramatic enhancement of a- and b-waves by an unknown mechanism independent of pupil dilation. | yes |
22961588 | Do biodegradable polymer-curcumin conjugate micelles enhance the loading and delivery of low-potency curcumin? | [
"To utilize a novel type of polymer-drug conjugate micelle to enhance the delivery of low-potency curcumin.",
"Multiple curcumin molecules were conjugated to poly(lactic acid) (PLA) via tris(hydroxymethyl)aminomethane (Tris) linker producing the hydrophobic drug-binding block; methoxy-poly(ethylene glycol) (mPEG)... | Micelle-forming polymer-drug conjugates containing multiple drug molecules were an efficient means to increase loading and intracellular delivery of low-potency curcumin. | yes |
7672165 | Is total antioxidant capacity of seminal plasma different in fertile and infertile men? | [
"To determine if the total antioxidant capacity of seminal plasma is different in fertile and infertile men.",
"An enhanced chemiluminescence assay applied to seminal plasma from groups of fertile and infertile men.",
"The Assisted Conception Unit, Royal Maternity Hospital, Belfast.",
"Men of proven fertility... | Seminal plasma from infertile men has lower antioxidant levels than that of fertile men, particularly of patients whose semen have poor sperm motility. The presence of reactive oxygen species activity in sperm of infertile groups also is associated with lower levels of chain-breaking antioxidants in seminal plasma. | yes |
21655327 | Does diversity in the reproductive modes of European Daphnia pulicaria deviate from the geographical parthenogenesis? | [
"Multiple transitions to obligate parthenogenesis have occurred in the Daphnia pulex complex in North America. These newly formed asexual lineages are differentially distributed being found predominantly at high latitudes. This conforms to the rule of geographical parthenogenesis postulating prevalence of asexuals ... | Inferred transitions to obligate parthenogenesis have occurred only in HTM, most likely as a result of hybridizations. In contrast to North American populations, these transitions do not appear to involve meiosis suppressor genes and have not been accompanied by polyploidy. The absence of obligate parthenogenesis in Py... | yes |
15364249 | Does a presumed missense mutation of RPGR cause abnormal RNA splicing with exon skipping? | [
"A patient with retinitis pigmentosa demonstrated a novel RPGR mutation (213G>A, last base of exon 2) predicted to cause a missense change (G52R) in the final protein. This study was performed to determine whether this mutation altered the effectiveness of the adjacent splice site.",
"Observational case report.",... | The last base of exons is conserved as "G" in 80% of splicing consensus sequences, yet when changed, can completely disrupt constitutive splicing as in this patient. Our data confirm that the evaluation of the effects of some DNA sequence alterations at the RNA level might have important implications for appropriate ge... | yes |
21296120 | Does major depressive disorder skewer the recognition of emotional prosody? | [
"Major depressive disorder (MDD) is associated with abnormalities in the recognition of emotional stimuli. MDD patients ascribe more negative emotion but also less positive emotion to facial expressions, suggesting blunted responsiveness to positive emotional stimuli. To ascertain whether these emotional biases are... | Impaired recognition of emotions would appear not to be specific to the visual modality but to be present also when emotions are expressed vocally, this impairment being related to depression severity and dysexecutive syndrome. MDD seems to skew the recognition of emotional prosody toward negative emotional stimuli and... | yes |
21814580 | Does low-level laser therapy activate NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts? | [
"Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation at a cellular level remain unclear.",
"In this study, we isolated murine embryonic fibroblasts (MEF) from transgenic NF-kB luciferase reporter mice and studied their response to 8... | We conclude that LLLT not only enhances mitochondrial respiration, but also activates the redox-sensitive NFkB signaling via generation of ROS. Expression of anti-apoptosis and pro-survival genes responsive to NFkB could explain many clinical effects of LLLT. | yes |
25682333 | Do infants Discriminate Voicing and Place of Articulation With Reduced Spectral and Temporal Modulation Cues? | [
"This study assessed the role of spectro-temporal modulation cues in the discrimination of 2 phonetic contrasts (voicing and place) for young infants.",
"A visual-habituation procedure was used to assess the ability of French-learning 6-month-old infants with normal hearing to discriminate voiced versus unvoiced ... | Altogether, these results indicate that the processing of modulation cues conveying phonetic information on voicing and place is "functional" at 6 months. The data also suggest that the perceptual weight of fast AM speech cues may change during development. | yes |
15183898 | Does polycomb group gene mel-18 modulate the self-renewal activity and cell cycle status of hematopoietic stem cells? | [
"Mel-18 is a member of the mammalian Polycomb group (PcG) genes. This family of genes regulates global gene expression in many biologic processes, including hematopoiesis and anterior-posterior axis formation by manipulating specific target genes, including members of the Hox family. Here, we demonstrate that mel-1... | Loss or knockdown of mel-18 leads to the expression of Hoxb4, an increase in the proportion of HSCs in G0 phase, and the subsequent promotion of HSC self-renewal. These findings will enable us to develop new approaches for controlling HSC activity for hematopoietic transplantations based on ex vivo expansion of HSCs. | yes |
23162013 | Does loss of CDKN2B promote p53-dependent smooth muscle cell apoptosis and aneurysm formation? | [
"Genomewide association studies have implicated allelic variation at 9p21.3 in multiple forms of vascular disease, including atherosclerotic coronary heart disease and abdominal aortic aneurysm. As for other genes at 9p21.3, human expression quantitative trait locus studies have associated expression of the tumor s... | These results suggest that reduced CDKN2B expression and increased smooth muscle cell apoptosis may be one mechanism underlying the 9p21.3 association with aneurysmal disease. | yes |
20927340 | Do novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging? | [
"Gadolinium (Gd), with its 7 unpaired electrons in 4f orbitals that provide a very large magnetic moment, is proven to be among the best agents for contrast enhanced MRI. Unfortunately, the most potent MR contrast agent based on Gd requires relatively high doses of Gd. The Gd-chelated to diethylene-triamine-penta-a... | The novel Gd-nanoparticles provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance. This new agent is likely to be suitable for patients exhibiting varying degrees of renal impairment. The simple and adaptive nanoparticle design could accommodate ligand or recept... | yes |
19856632 | Is measurement of gait speed of older adults feasible and informative in a home-care setting? | [
"Although gait speed is widely recommended as a measure of activity limitation, it is not routinely used clinically with older adults. This retrospective study was undertaken to determine whether the measurement of gait speed is feasible and informative in a home care setting.",
"The therapy records of 27 ambulat... | Measurement of the gait speed of older adults is feasible in a home care setting. Its sensitivity to limitations not revealed by other measures provides support for broader use. | yes |
19607704 | Does silencing of genes involved in Anaplasma marginale-tick interactions affect the pathogen developmental cycle in Dermacentor variabilis? | [
"The cattle pathogen, Anaplasma marginale, undergoes a developmental cycle in ticks that begins in gut cells. Transmission to cattle occurs from salivary glands during a second tick feeding. At each site of development two forms of A. marginale (reticulated and dense) occur within a parasitophorous vacuole in the h... | The results of this RNAi and light microscopic analyses of tick tissues infected with A. marginale after the silencing of genes functionally important for pathogen development suggest a role for these molecules during pathogen life cycle in ticks. | yes |
20031755 | Do clinical significance of echo signal attenuation on intravascular ultrasound in patients with coronary artery disease? | [
"Atherosclerotic plaque that shows echo signal attenuation (EA) without associated bright echoes is sometimes observed by intravascular ultrasound but its clinical significance remains unclear. We investigated the impact of EA on coronary perfusion and evaluated the pathological features of plaque with EA.",
"We ... | Atherosclerotic plaque with EA showed a significant association with no reflow after percutaneous coronary intervention, suggesting the existence of fragile components susceptible to distal embolization. | yes |
21622813 | Are drug-induced torsade de pointes arrhythmias in the chronic AV block dog perpetuated by focal activity? | [
"The electrically remodeled canine heart after chronic AV block (CAVB) has a high susceptibility for drug-induced torsade de pointes (TdP) arrhythmias. Although focal mechanisms have been considered for initiation, there is still controversy about whether reentry is the dominant mechanism for perpetuation of TdP. I... | Focal activity is the dominant mechanism involved in perpetuation of ibutilide-induced TdP in CAVB dogs based on detailed 3D mapping. This conclusion is in line with unaltered conduction and documented increase in VERP. | yes |
25592682 | Do immature platelet fraction values predict recovery of platelet counts following liver transplantation? | [
"Thrombocytopenia after orthotopic liver transplantation (OLT) is a well-recognized and prevalent early postoperative complication. In the current study, we assessed the clinical utility of the immature platelet fraction (expressed as a percent of total platelets, IPF %) to predict platelet count recovery following... | The IPF % increased prior to the elevation of platelet counts in patients with OLT suggesting that the IPF % may reflect production of platelets. These findings suggest IPF% could be useful as a predictor of platelet recovery in patients with OLT. | yes |
26441079 | Are tight junction defects seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer? | [
"Oral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can lead to poor clinical outcomes and extensive resource utilisation. The primary aim of this study was to determine the molecular integrity of oral epithelial tight ... | Chemotherapy causes defects in oral tight junctions, coupled with altered cytokine and matrix metalloproteinase profiles. Tight junction disruption in the epithelium may contribute to ulcer development or lead to poor tissue integrity, and the timing of these events may be a target for preventative treatment. | yes |
27506476 | Does casein glycomacropeptide-derived peptide IPPKKNQDKTE ameliorate high glucose-induced insulin resistance in HepG2 cells via activation of AMPK signaling? | [
"Recently, casein glycomacropeptide (GMP)-derived peptide was found to possess potent antioxidant and anti-inflammatory activities. In this study, the improvement effects and underlying molecular mechanisms of GMP-derived peptide on hepatic insulin resistance were investigated.",
"The peptide IPPKKNQDKTE was iden... | IPPKKNQDKTE prevents high glucose-induced insulin resistance in HepG2 cells by modulating the IRS-1/PI3K/Akt signaling pathway through AMPK activation, indicating that IPPKKNQDKTE plays a potential role in the prevention and treatment of hepatic insulin resistance and type 2 diabetes. | yes |
19534015 | Does multidisciplinary assessment of elderly people with a history of multiple fall reduces the risk of further falls? | [
"Does assessment by a multidisciplinary team, or assessment by a community nurse with the ability to refer to other professionals, reduce further falls in recurrent fallers?",
"Cluster-randomised, controlled trial.",
"18 general practices in the UK.",
"Adults aged at least 65 years, living in the community, w... | Multidisciplinary assessment of elderly, recurrent fallers reduces the risk of further falls compared to usual care. Assessment of risk factors for falls by a community nurse with the potential to refer to other professionals did not have the same benefit. | yes |
21729327 | Does beta-amyloid increase the expression level of ATBF1 responsible for death in cultured cortical neurons? | [
"Recently, several lines of evidence have shown the aberrant expression of cell-cycle-related proteins and tumor suppressor proteins in vulnerable neurons of the Alzheimer's disease (AD) brain and transgenic mouse models of AD; these proteins are associated with various paradigms of neuronal death. It has been repo... | To the best of our knowledge, this is the first report that Aβ1-42 and DNA-damaging drugs increased the ATBF1 expression level in primary rat cortical neurons; this increase, in turn, may activate ATM signaling responsible for neuronal death through the binding of ATBF1 to phosphorylated ATM. ATBF1 may therefore be a s... | yes |
21300075 | Does rb1 postconditioning attenuate liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway? | [
"Ginsenoside Rb1 could prevent ischemic neuronal death and focal cerebral ischemia, but its roles to liver warm I/R injury remain to be defined. We determined if Rb1 would attenuate warm I/R injury in mice.",
"Mice were divided into sham, I/R, Rb1+I/R (Rb1 postconditioning, 20mg/kg, i.p. after ischemia), sham+L-N... | We found that Rb1 postconditioning could protect liver from I/R injury by upregulating the content of NO and NOS, and also HIF-1alpha protein expression. These protective effects could be abolished by L-NAME. These findings suggested Rb1 may have the therapeutic potential through ROS-NO-HIF pathway for management of li... | yes |
23433826 | Do platelet-derived microparticles augment the adhesion and neovascularization capacities of circulating angiogenic cells obtained from atherosclerotic patients? | [
"The neovascularization-related capacities of circulating angiogenic cells (CACs) are impaired in atherosclerotic patients, which may explain the unsatisfactory effects of therapeutic angiogenesis with atherosclerotic patient-derived CACs. Platelet-derived microparticles (PMPs) were reported to augment the re-endot... | PMP-secreted RANTES may play a role in the augmenting adhesion and neovascularization capacities of CACs. Injection of PMP-CACs may be a new strategy to augment the effects of therapeutic angiogenesis for limb ischemia in atherosclerotic patients. | yes |
19229673 | Are myocardial performance and aortic elasticity impaired in patients with ankylosing spondylitis? | [
"To measure aortic stiffness and global left ventricular (LV) function in patients with ankylosing spondylitis (AS) and no clinical evidence of heart disease.",
"Fifty-seven consecutive patients with AS (54 males, three females, mean age 41.78+/-10.02 years) without clinical evidence of cardiac involvement and 78... | Patients with AS and no clinical evidence of cardiac disease have increased stiffness of the aorta and decreased global myocardial performance and both of these abnormal measurements correlate with disease activity. The abnormal Tei index may reflect an early manifestation of cardiac dysfunction in these patients. | yes |
10599784 | Do brief bursts of pulse stimulation terminate afterdischarges caused by cortical stimulation? | [
"To determine whether cortical electrical stimulation can terminate bursts of epileptiform activity in humans, we used afterdischarges (ADs) as a model of epileptiform activity.",
"Cortical stimulation was performed for clinical localization purposes using subdural electrodes implanted in patients undergoing prer... | Afterdischarges significantly decreased in duration after we applied brief bursts of pulse stimulation. Although afterdischarges are not identical to spontaneous epileptiform activity, these results support the idea that electrical stimulation, applied in an appropriate manner at seizure onset, could abort seizures in ... | yes |
18930987 | Does infliximab improve vascular stiffness in patients with rheumatoid arthritis? | [
"Patients with rheumatoid arthritis (RA) have increased cardiovascular mortality. Tumour necrosis factor alpha (TNFalpha)-blocking therapy has been shown to reduce RA disease activity measures and joint damage progression. Some observational studies suggest that TNFalpha blockade reduces mortality and incidence of ... | Arterial stiffness improves with infliximab treatment in RA. This change may help explain the improved cardiovascular disease survival in patients with RA receiving TNFalpha-blocking therapy. | yes |
22850187 | Is psychosocial stress during pregnancy related to adverse birth outcomes : results from a large multi-ethnic community-based birth cohort? | [
"Prevalence rates of psychosocial stress during pregnancy are substantial. Evidence for associations between psychosocial stress and birth outcomes is inconsistent. This study aims to identify and characterize different clusters of pregnant women, each with a distinct pattern of psychosocial stress, and investigate... | Babies from pregnant women reporting both high levels of anxiety and depressive symptoms are at highest risk for adverse birth outcomes. | yes |
15695104 | Do plasma factors in severe early-onset preeclampsia substantially alter endothelial gene expression in vitro? | [
"Systemic endothelial dysfunction is a central feature in the pathophysiology of preeclampsia. Its cell biologic and molecular basis is poorly understood. One leading hypothesis argues that endothelial dysfunction is caused by (at present largely unknown) circulating factors released from the ischemic placenta. Thi... | In vitro, plasma from preeclamptic patients does not substantially alter endothelial gene expression profile. Only modest induction of IL-8 gene expression was observed. These results indicate that mechanisms other than soluble plasma constituents are likely involved in systemic endothelial cell activation in preeclamp... | no |
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