id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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22302658 | Does limb-salvage surgery offer patients better quality of life and functional capacity than amputation? | [
"Patients with aggressive lower extremity musculoskeletal tumors may be candidates for either above-knee amputation or limb-salvage surgery. However, the subjective and objective benefits of limb-salvage surgery compared with amputation are not fully clear.QUESTIONS/",
"We therefore compared functional status and... | These data suggest that limb-salvage surgery offers better gait efficiency and return to normal living compared with above-knee amputation, but does not improve the patient's perception of quality of life. | maybe |
18096128 | Cervical spine fractures in geriatric blunt trauma patients with low-energy mechanism: are clinical predictors adequate? | [
"Studies have identified clinical predictors to guide radiologic evaluation of the cervical spine in geriatric patients. We hypothesized that clinical predictors are not adequate in the identification of cervical spine fractures in geriatric blunt trauma patients with low-energy mechanism.",
"A retrospective case... | Clinical predictors appear inadequate for the evaluation of the cervical spine in geriatric trauma patients with low-energy mechanism. | no |
12913347 | Do microbiological factors account for poor pregnancy outcome among unmarried pregnant women in Poland? | [
"Being unmarried is a well-known risk factor for poor pregnancy outcome such as preterm delivery and intrauterine growth restriction. The aim of this prospective study was to assess the prevalence and risk of bacterial vaginosis (BV) and selected bacteria isolated from the lower genital tract and to determine the s... | The observed socioeconomic, demographic and microbiological differences between unmarried and married women could be responsible for the poor pregnancy outcome among unmarried pregnant women in Poland. Unmarried pregnant women should be covered by comprehensive medical care even before pregnancy. Further studies taking... | yes |
24684514 | Should all patients be optimized to the same preoperative hemoglobin level to avoid transfusion in primary knee arthroplasty? | [
"Optimization of the preoperative hemoglobin (Hb) level is an effective way to reduce allogeneic transfusion in total knee arthroplasty (TKA) though the procedure is expensive, requires close monitoring and is often inconvenient for patients with reduced mobility. Our aim was to investigate the value of preoperativ... | Not all the patients undergoing TKA who receive tranexamic acid need the same preoperative Hb optimization target. Two easily available factors, such as the ASA score and the Hb level, can help individualize the Hb optimization target. | no |
24793469 | Is there any relation between cervical cord plaques and discopathy in patients with multiple sclerosis? | [
"Multiple sclerosis (MS) is the most common chronic autoimmune demyelinating disease of the central nervous system. The purpose of this study is to determine the relationship between the site of the cervical discopathy and cervical spinal cord plaque in MS patients.",
"This retrospective study included all patien... | The study data suggests a possible correlation between cervical discopathy and cervical MS plaque. | yes |
23360491 | Is the processing of affective prosody influenced by spatial attention? | [
"The present study asked whether the processing of affective prosody is modulated by spatial attention. Pseudo-words with a neutral, happy, threatening, and fearful prosody were presented at two spatial positions. Participants attended to one position in order to detect infrequent targets. Emotional prosody was tas... | Emotional prosody, therefore, seems to be partially processed outside the focus of spatial attention. Whereas at early sensory processing stages spatial attention modulates the degree of emotional voice processing as a function of emotional valence, emotional prosody is processed outside of the focus of spatial attenti... | maybe |
10340286 | Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly? | [
"The diagnosis of acute appendicitis is still difficult and the results are unsatisfactory in three particular patient groups: in children, in fertile-age women and in elderly patients. As our population ages, the challenge for expedient diagnosis and intervention in older age groups will become more and more signi... | Although elevated leukocyte count and CRP value cannot effectively establish the diagnosis of acute appendicitis in the elderly, unelevated values exclude it. Accordingly, appendectomy is not recommended to be performed in an elderly patient with unelevated leukocyte count and CRP value, although clinical symptoms and ... | maybe |
22954812 | Are bipolar disorders underdiagnosed in patients with depressive episodes? | [
"Recent reports indicate that the prevalence of bipolar disorder (BD) in patients with an acute major depressive episode might be higher than previously thought. We aimed to study systematically all patients who sought therapy for major depressive episode (MDE) within the BRIDGE study in Germany, reporting on an in... | The diagnosis of BD in patients with MDE depends strongly on the method and criteria employed. The considerable difference between criteria-free physician's diagnosis and the remaining algorithms indicate the usefulness of criteria lists within the everyday clinical setting. | maybe |
26237424 | Does patient-prosthesis mismatch after aortic valve replacement affect survival and quality of life in elderly patients? | [
"To evaluate the impact of patient-prosthesis mismatch (PPM) on survival, functional status, and quality of life (QoL) after aortic valve replacement (AVR) with small prosthesis size in elderly patients.",
"Between January 2005 and December 2013, 152 patients with pure aortic stenosis, aged at least 75 years, und... | PPM after AVR does not affect survival, functional status, and QoL in patients aged at least 75 years. Surgical procedures, often time-consuming, contemplated to prevent PPM, may therefore be not justified in this patient subgroup. | no |
20813740 | Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid? | [
"48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.",
"Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with ... | Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the... | yes |
20401819 | Is ultrasound equal to X-ray in pediatric fracture diagnosis? | [
"Ultrasound is currently not established for the diagnosis of fractures. The aim of this study was to compare ultrasound and X-ray beyond their use solely for the identification of fractures, i. e., for the detection of fracture type and dislocation for pediatric fracture diagnosis.",
"Limb bones of dead young pi... | Ultrasound not only has comparable sensitivity to that of X-ray for the identification of limb fractures but is also equally effective for the diagnosis of fracture type and dislocation. Thus, ultrasound can be used as an adequate alternative method to X-ray for pediatric fracture diagnosis. | yes |
25255719 | Hearing loss: an unknown complication of pre-eclampsia? | [
"This prospective case-control study consisted of 33 patients with pre-eclampsia and 32 normotensive pregnant patients as controls. All of the subjects underwent otoscopic examinations - pure tone audiometry (0.25-16 kHz) and transient evoked otoacoustic emission (1-4 kHz) tests - during their third trimester of pr... | Pre-eclampsia is a potential risk factor for cochlear damage and sensorineural hearing loss. Further studies that include routine audiological examinations are needed in these patients. | yes |
24973051 | Medical student education in emergency medicine: do students meet the national standards for clinical encounters of selected core conditions? | [
"Establishing a core curriculum for undergraduate Emergency Medicine (EM) education is crucial to development of the specialty. The Clerkship Directors in Emergency Medicine (CDEM) National Curriculum Task Force recommended that all students in a 4(th)-year EM clerkship be exposed to 10 emergent clinical conditions... | Most students do not encounter all 10 conditions during patient encounters throughout a 4-week EM rotation, although most have exposure to at least eight. Certain conditions are far less likely than others to be encountered, and may need to be taught in a nonclinical setting. | no |
20497146 | A model of healing of Los Angeles grades C and D reflux oesophagitis: is there an optimal time of acid suppression for maximal healing? | [
"In patients with Los Angeles (LA) grade C or D oesophagitis, a positive relationship has been established between the duration of intragastric acid suppression and healing.AIM: To determine whether there is an apparent optimal time of intragastric acid suppression for maximal healing of reflux oesophagitis.",
"P... | After 4 weeks' acid-suppressive therapy for LA grade C or D oesophagitis, successful healing appears to reach a threshold above which improvements are unlikely to be achieved despite an increase in number of hours with intragastric pH>4. | yes |
19401574 | Gadofosveset-enhanced MR angiography of carotid arteries: does steady-state imaging improve accuracy of first-pass imaging? | [
"To evaluate the diagnostic accuracy of gadofosveset-enhanced magnetic resonance (MR) angiography in the assessment of carotid artery stenosis, with digital subtraction angiography (DSA) as the reference standard, and to determine the value of reading first-pass, steady-state, and \"combined\" (first-pass plus stea... | Gadofosveset-enhanced MR angiography is a promising technique for imaging carotid artery stenosis. Steady-state image reading is superior to first-pass image reading, but the combined reading protocol is more accurate. | yes |
25228241 | Elephant trunk in a small-calibre true lumen for chronic aortic dissection: cause of haemolytic anaemia? | [
"The elephant trunk technique for aortic dissection is useful for reducing false lumen pressure; however, a folded vascular prosthesis inside the aorta can cause haemolysis. The purpose of this study was to investigate whether an elephant trunk in a small-calibre lumen can cause haemolysis.",
"Inpatient and outpa... | A folded elephant trunk in a small-calibre lumen can cause haemolysis. Therefore, inserting an elephant trunk in a small-calibre true lumen during surgery for chronic aortic dissection should be avoided. | yes |
10927144 | Can p53 alterations be used to predict tumour response to pre-operative chemo-radiotherapy in locally advanced rectal cancer? | [
"To examine whether p53 tumour suppressor gene alterations can be used to predict tumour response to pre-operative chemo-radiation in locally advanced rectal cancer in terms of reduction in tumour size and local failure.",
"p53 alterations were studied in pre-treatment biopsy specimens of rectal carcinomas from 4... | p53 alteration detected by IHC or SSCP analysis is not a clinically useful predictor of local response to pre-operative adjuvant therapy in advanced rectal carcinoma. | no |
9347843 | Laparoscopic-assisted ileocolic resections in patients with Crohn's disease: are abscesses, phlegmons, or recurrent disease contraindications? | [
"Because of the inflammatory nature of Crohn's disease, ileocolic resections are often difficult to perform, especially if an abscess, phlegmon, or recurrent disease at a previous ileocolic anastomosis is present. Our goal was to determine whether the above factors are contraindications to a successful laparoscopic... | The laparoscopic-assisted approach to Crohn's disease is feasible and safe with good outcomes. Co-morbid preoperative findings such as abscess, phlegmon, or recurrent disease at the previous ileocolic anastomosis are not contraindications to a successful laparoscopic-assisted ileocolic resection in select patients. | no |
23072266 | Has the use of complementary and alternative medicine therapies by U.S. adults with chronic disease-related functional limitations changed from 2002 to 2007? | [
"This study examined changes in the use of complementary and alternative medicine (CAM) therapies by U.S. adults aged 18 years or older with chronic disease-related functional limitations between 2002 and 2007.",
"The study was a cross-sectional survey.SETTING/",
"The study was conducted in the United States.",... | Among U.S. adults with chronic disease-related functional limitations, the overall increase in CAM use from 2002 to 2007 was significant, particularly among those with changing and maintaining body position limitations. | yes |
12607666 | Is extended aortic replacement in acute type A dissection justifiable? | [
"The aim of this study was to evaluate the effectiveness of our surgical strategy for acute aortic dissection based on the extent of the dissection and the site of the entry, with special emphasis on resection of all dissected aortic segments if technically possible.",
"Between January 1995 and March 2001, 43 con... | Extended replacement of the dissected ascending aorta and aortic arch can be done with good early and midterm results, even though it requires a complex surgical technique. Therefore we advocate complete replacement of the dissected parts of the aorta in all patients in whom this is technically possible. | yes |
24074624 | Is intensive monitoring during the first transfusion in pediatric patients necessary? | [
"Some pediatric patients, typically those that are very young or felt to be especially sick are temporarily admitted to the intensive care unit (ICU) for observation during their first transfusion. If a significant reaction that requires ICU management does not occur, these patients are then transferred to a regula... | The practice of intensive observation for the first transfusion in pediatric patients is probably unnecessary. | no |
17224424 | Effects of exercise training on heart rate and QT interval in healthy young individuals: are there gender differences? | [
"The aim of the present study was to assess the effects of exercise training on heart rate, QT interval, and on the relation between ventricular repolarization and heart rate in men and women.",
"A 24 h Holter recording was obtained in 80 healthy subjects (40 males) who differed for the degree of physical activit... | The results of this study suggest that the cardiovascular response to exercise training may be different in men and women. Women may benefit more from interventions aimed to increase physical activity as a tool for prevention of cardiovascular morbidity and mortality. | yes |
16097998 | Is coeliac disease screening in risk groups justified? | [
"The benefits of serologic screening for coeliac disease in asymptomatic individuals are debatable.AIM: To investigate dietary compliance, quality of life and bone mineral density after long-term treatment in coeliac disease patients found by screening in risk groups.",
"The study comprised 53 consecutive screen-... | Long-term dietary compliance in screen-detected patients was good. Quality of life and bone mineral density were comparable with those in non-coeliac subjects and the general population. Active screening in coeliac disease risk groups seems to be reasonable rather than harmful. | yes |
25487603 | Analysis of the epidemiological pattern of Shigellosis in Barcelona between 1988 and 2012: Is it an emerging sexually transmitted infection? | [
"The aim of this study was to describe the evolution and epidemiologic characteristics of shigellosis patients over a 25 year period in a large city.",
"Shigellosis is a notifiable disease in Spain since 1988. Cases are analyzed in Barcelona residents included in the registry between 1988-2012. A descriptive anal... | An increased trend was detected in men who had no history of food poisoning or travel to endemic areas. This increase points to a change in the pattern of shigellosis, becoming predominantly male and its main mechanism probably by sexual transmission. | yes |
20594006 | A patient with myelomeningocele: is untethering necessary prior to scoliosis correction? | [
"Tethering of the spinal cord is thought to increase the chance of neurological injury when scoliosis correction is undertaken. All patients with myelomeningocele (MM) are radiographically tethered, and untethering procedures carry significant morbidity risks including worsening neurological function and wound comp... | The study results suggested that spinal cord untethering may be unnecessary in patients with MM who are undergoing scoliosis corrective surgery and do not present with clinical symptoms of a tethered cord, even though tethering is radiographically demonstrated. | no |
26363639 | Is aerobic workload positively related to ambulatory blood pressure? | [
"Cardiovascular disease is prevalent among workers with high levels of occupational physical activity. The increased risk may be due to a high relative aerobic workload, possibly leading to increased blood pressure. However, studies investigating the relation between relative aerobic workload and ambulatory blood p... | Because workers may have an elevated relative aerobic workload for several hours each working day, this relationship may elucidate a mechanism behind the increased risk for cardiovascular disease among workers exposed to high levels of occupational physical activity. | yes |
27405146 | PREVALENCE OF THE STREPTOCOCUS AGALACTIAE IN THE PREGNANT WOMAN FROM THE AUTONOMIC CITY OF MELILLA: IS CULTURE A DETERMINANT FACTOR? | [
"The neonatal infection by Streptococcus group B is one of the main causes of neonatal morbi-mortality rate. For this reason a screening is made to each pregnant woman in order to detect its presence, and if it was the case, to apply an antibiotic treatment during labour. The aim of this study was to know the preva... | The prevalence of vagino-rectal colonization by Streptococcus group B in the pregnant women from Melilla is within the national estimated figures, however it is different if they are from Muslim or Christian culture, being higher in the Muslim population. On one hand both prevalences are within the national statistics,... | yes |
25443385 | Are virtual planning and guided surgery for head and neck reconstruction economically viable? | [
"Virtual planning and guided surgery with or without prebent or milled plates are becoming more and more common for mandibular reconstruction with fibular free flaps (FFFs). Although this excellent surgical option is being used more widely, the question of the additional cost of planning and cutting-guide productio... | Even in capped health care systems, virtual planning and guided surgery including prebent or milled plates are financially viable. | yes |
9044116 | Biliary atresia: should all patients undergo a portoenterostomy? | [
"The management of noncorrectable extra hepatic biliary atresia includes portoenterostomy, although the results of the surgery are variable. This study was done to develop criteria that could successfully predict the outcome of surgery based on preoperative data, including percutaneous liver biopsy, allowing a more... | Based on the predictive information available in a liver biopsy, we conclude that those patients who will not benefit from a Kasai procedure can be identified preoperatively, and channeled immediately to transplantation. | no |
21084567 | Are stroke patients' reports of home blood pressure readings reliable? | [
"Home blood pressure (BP) monitoring is gaining increasing popularity among patients and may be useful in hypertension management. Little is known about the reliability of stroke patients' records of home BP monitoring.",
"To assess the reliability of home BP recording in hypertensive patients who had suffered a ... | This group of elderly stroke patients were able to record their BPs reliably at home. Any bias was small and would be unlikely to affect management. Since BP readings in a GP surgery are often a poor indication of true BP, GPs might consider using hypertensive patients' records of home BP monitoring to help guide treat... | yes |
27991408 | Do dermatomyositis and polymyositis affect similar thigh muscles? | [
"Dermatomyositis (DM) and polymyositis (PM) commonly cause weakness of the thigh muscles. However, it is debated whether DM and PM affect similar thigh muscles. Muscle oedema on fat-suppressed MRI sequences is thought to represent active inflammation. In this study, we aimed to assess which thigh muscle groups are ... | Compared with PM, DM affects more thigh muscles, except those of the posterior compartment, which are equally involved in both disorders. These findings may be useful to target physiotherapy at the more frequently affected muscles. | no |
14655021 | Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis? | [
"Juvenile and adult forms of ankylosing spondylitis (AS) have been shown to have different clinical presentation and outcome in Caucasians. We did this retrospective analysis to see if similar differences exist in the Indian population.",
"Case records of 210 Indian patients diagnosed with AS according to modifie... | In this group of subjects, juvenile AS had onset more often with oligoarthritis and enthesitis than with spinal disease. Hip and knee joint involvement was more common in JAS than AAS. | no |
26175531 | Is Aspiration Thrombectomy Beneficial in Patients Undergoing Primary Percutaneous Coronary Intervention? | [
"It is unclear whether intravenous glycoprotein IIb/IIIa inhibitors or ischemic time might modify any clinical benefits observed with aspiration thrombectomy before primary percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction.",
"Electronic databases were searched f... | Aspiration thrombectomy before primary PCI is not associated with any benefit on clinical end points and might increase the risk of stroke. Concomitant administration of intravenous glycoprotein IIb/IIIa inhibitors and ischemic time did not seem to influence any potential benefits observed with aspiration thrombectomy. | no |
25168472 | Can static foot posture measurements predict regional plantar surface area? | [
"The intent of this study was to determine if the use of a single or combination of static foot posture measurements can be used to predict rearfoot, midfoot, and forefoot plantar surface area in individuals with pronated or normal foot types.",
"Twelve foot measurements were collected on 52 individuals (mean age... | The results indicate that clinicians can use a combination of simple, reliable and time efficient foot measures to explain 79% and 85% of the plantar surface area in the forefoot and midfoot, respectively. | yes |
9446993 | Can dentists recognize manipulated digital radiographs? | [
"To determine the ability of dentists to recognize digitally manipulated radiographs.",
"A poster was presented at the Annual Meeting of the German Society for Periodontology displaying the intra-oral radiographs of 12 different patients. Half of the radiographs were subjected to digital manipulation to add or re... | Image manipulations which alter the diagnostic content of a radiograph are unlikely to be detected by dentists. Digital radiography requires additional measures for data protection. | no |
10473855 | Is delayed gastric emptying following pancreaticoduodenectomy related to pylorus preservation? | [
"Delayed gastric emptying (DGE) is the most frequent postoperative complication after pylorus-preserving pancreaticoduodenectomy (PPPD). This prospective, non-randomized study was undertaken to determine whether the incidence of DGE may be reduced by modifying the original reconstructive anatomy with a retrocolic d... | DGE after PPPD seems to be of minor clinical importance following uncomplicated surgery. When taking the results into consideration, it can be said that, despite the lack of a control group, antecolic duodenojejunostomy might be the key to a low incidence of DGE after PPPD. In our experience, DGE is linked to the occur... | no |
28006766 | Is Overexpression of Ki-67 a Prognostic Biomarker of Upper Tract Urinary Carcinoma? | [
"Upper tract urinary carcinoma (UTUC) is a relatively uncommon but aggressive disease. The Ki-67 antigen is a classic marker of cellular proliferation, but there is still controversy regarding the significance and importance of Ki-67 in tumor progression.",
"In this study, we first detected Ki-67 expression in UT... | In conclusion, high Ki-67 expression was associated with poor survival in patients with UTUC, as well as a high risk of disease progression, although these findings need to be interpreted with caution. Large-scale, adequately designed, prospective trials are needed to further confirm the value of Ki-67 in prognosis of ... | yes |
12095973 | Chemoradiation instead of surgery to treat mid and low rectal tumors: is it safe? | [
"The main treatment for rectal carcinoma is surgery. Preoperative chemoradiation (CRT) is advocated to reduce local recurrence and improve resection of mid and low tethered rectal tumors.",
"Fifty-two patients with mid or low rectal tumors underwent CRT (external beam radiation plus 5-fluorouracil plus folinic ac... | Exclusive CRT approach is not safe to treat patients with low infiltrative rectal carcinoma. | no |
21558951 | Are there effects of intrauterine cocaine exposure on delinquency during early adolescence? | [
"To ascertain whether level of intrauterine cocaine exposure (IUCE) is associated with early adolescent delinquent behavior, after accounting for prenatal exposures to other psychoactive substances and relevant psychosocial factors.",
"Ninety-three early adolescents (12.5-14.5 years old) participating since birth... | In this cohort, prospectively ascertained prenatal exposure to cigarettes and childhood exposure to violence are associated with self-reported delinquent behaviors during early adolescence. Contrary to initial popular predictions, intrauterine cocaine is not a strong predictor of adolescent delinquent behaviors in this... | no |
17062225 | Thoracic and thoracoabdominal aneurysm repair: is reimplantation of spinal cord arteries a waste of time? | [
"The impact of different strategies for management of intercostal and lumbar arteries during repair of thoracic and thoracoabdominal aortic aneurysms (TAA/A) on the prevention of paraplegia remains poorly understood.",
"One hundred consecutive patients with intraoperative monitoring of motor evoked potentials (ME... | With monitoring of MEP and SSEP, sacrifice--without reimplantation--of as many as 15 intercostal and lumbar arteries during TAA/A repair is safe, resulting in acceptably low rates of immediate and delayed paraplegia. This experience suggests that routine surgical implantation of segmental vessels is not indicated, and ... | yes |
14713788 | Is year of radical prostatectomy a predictor of outcome in prostate cancer? | [
"We examined whether the year in which radical prostatectomy (RP) was performed is a predictor of treatment outcome after controlling for standard prognostic factors.",
"We examined the association between RP year and outcome in 6,556 patients from 7 centers using preoperative and pathological features. Patients ... | When controlling for preoperative features, the year in which RP was performed is a predictor of outcome on multivariate analysis. This effect could not be explained by stage migration. | yes |
24374414 | Does health information exchange reduce redundant imaging? | [
"Broad-based electronic health information exchange (HIE), in which patients' clinical data follow them between care delivery settings, is expected to produce large quality gains and cost savings. Although these benefits are assumed to result from reducing redundant care, there is limited supporting empirical evide... | HIE was associated with reduced repeat imaging in EDs. This study is among the first to find empirical support for this anticipated benefit of HIE. | yes |
10577397 | Is a pressor necessary during aortic perfusion and oxygenation therapy of cardiac arrest? | [
"Occlusion of the descending aorta and infusion of oxygenated ultrapurified polymerized bovine hemoglobin may improve the efficacy of advanced cardiac life support (ACLS). Because selective aortic perfusion and oxygenation (SAPO) directly increases coronary perfusion pressure, exogenous epinephrine may not be requi... | The addition of epinephrine to ACLS-SAPO increases vital organ perfusion pressures and improves outcome from cardiac arrest. There appears to be a profound loss of arterial vasomotor tone after prolonged arrest. This loss of vasomotor tone may make exogenous pressors necessary for resuscitation after prolonged cardiac ... | yes |
15369037 | Do people who were passive smokers during childhood have increased risk of long-term work disability? | [
"Regular inhalation of tobacco smoke, whether it be voluntary or not, may have profound negative effects on the body. Also intervertebral discs may be affected. The objective of the present study was to test the hypothesis that nurses' aides who were exposed to environmental tobacco smoke (ETS) at home during child... | The study supports the hypothesis that nurses' aides who were exposed to ETS at home during childhood have an increased risk of long-term sickness absence. | yes |
21951591 | Motor performance in chronic low back pain: is there an influence of pain-related cognitions? | [
"Chronic low back pain (CLBP) is often accompanied by an abnormal motor performance. However, it has not been clarified yet whether these deviations also occur during motor tasks not involving the back and whether the performance is influenced by pain and pain-related cognitions. Therefore, the aim of the present s... | It can be concluded that CLBP patients in general have worse motor task performance compared to healthy subjects and that provoking pain-related cognitions further worsened performance. | yes |
18619710 | Patient comprehension of emergency department care and instructions: are patients aware of when they do not understand? | [
"To be able to adhere to discharge instructions after a visit to the emergency department (ED), patients should understand both the care that they received and their discharge instructions. The objective of this study is to assess, at discharge, patients' comprehension of their ED care and instructions and their aw... | Many patients do not understand their ED care or their discharge instructions. Moreover, most patients appear to be unaware of their lack of understanding and report inappropriate confidence in their comprehension and recall. | no |
18784527 | Can mandibular depiction be improved by changing the thickness of double-oblique computed tomography images? | [
"Multislice helical computed tomography (CT), which can provide detailed 2-D and 3-D reconstructed images, is useful in imaging diagnosis for dental implant treatment. Therefore, in this study, it was performed to clarify the mandibular depiction of double-oblique reconstructed images when changing their thickness.... | We concluded that depiction of the superior wall of the mandibular canal cannot be improved by changing the thickness of images. | no |
2503176 | Inhibin: a new circulating marker of hydatidiform mole? | [
"To define the concentrations of inhibin in serum and tissue of patients with hydatidiform mole and assess their value as a clinical marker of the condition.",
"Prospective study of new patients with hydatidiform mole, comparison of paired observations, and case-control analysis.",
"A university hospital, two l... | In this small study serum inhibin concentrations higher than those found in the early follicular phase one to two weeks after evacuation of a hydatidiform mole seemed to be specific for persistent trophoblastic disease. Further data are needed to confirm these promising results. | yes |
22108230 | Is the fibronectin-aggrecan complex present in cervical disk disease? | [
"To investigate the presence of inflammatory cytokines and the fibronectin-aggrecan complex (FAC) in persons undergoing surgical treatment for cervical radiculopathy caused by disk herniation.",
"Single-center, prospective, consecutive case series.",
"A single large academic institution.",
"A total of 11 pati... | Biochemical analysis of injured cervical intervertebral disks reveals the presence of inflammatory markers such as MCP, fragments of structural matrix proteins such as FAC, and a correlation with pH. Further evaluation of the FAC as a potential diagnostic biomarker or therapeutic target is warranted in the cervical spi... | yes |
20338971 | Does peritoneal dialysis affect halitosis in patients with end-stage renal disease? | [
"There are various causes of halitosis, one of which is chronic renal failure. The objective of this study was to investigate halitosis levels in end-stage renal disease (ESRD) patients before and after peritoneal dialysis (PD) therapy.",
"42 subjects with ESRD were included in this study. The presence of halitos... | High BUN levels and low salivary flow rates were found to be associated with halitosis. PD may play an important role in decreasing the level of halitosis in ESRD patients. | yes |
17276801 | Can elevated troponin I levels predict complicated clinical course and inhospital mortality in patients with acute pulmonary embolism? | [
"The purpose of this study was to evaluate the value of elevated cardiac troponin I (cTnI) for prediction of complicated clinical course and in-hospital mortality in patients with confirmed acute pulmonary embolism (PE).",
"This study was a retrospective chart review of patients diagnosed as having PE, in whom cT... | Our results indicate that elevated cTnI levels are associated with higher risk for inhospital mortality and complicated clinical course. Troponin I may play an important role for the risk assessment of patients with PE. The idea that an elevation in cTnI levels is a valuable parameter for the risk stratification of pat... | yes |
20497880 | Is transurethral catheterisation the ideal method of bladder drainage? | [
"Bladder catheterisation is a routine part of major abdominal surgery. Transurethral catheterisation is the most common method of bladder drainage but is also notorious for its discomfort and increased risk of urinary tract infection. The present study aimed to establish patient satisfaction with transurethral cath... | Our study emphasised the discomfort of transurethral urinary catheters, especially in male patients, and the high incidence of urinary tract infections in both sexes. Consideration should be given to the utilisation of alternative methods of bladder drainage, such as suprapubic catheterisation, which can be performed w... | no |
26701174 | Inpatient Pediatric Tonsillectomy: Does Hospital Type Affect Cost and Outcomes of Care? | [
"To ascertain whether hospital type is associated with differences in total cost and outcomes for inpatient tonsillectomy.",
"Cross-sectional analysis of the 2006, 2009, and 2012 Kids' Inpatient Database (KID).",
"Children ≤18 years of age undergoing tonsillectomy with/without adenoidectomy were included. Risk-... | Significant differences in costs, outcomes, and patient factors exist for inpatient tonsillectomy based on hospital type. Although reasons for these differences are not discernable using isolated claims data, findings provide a foundation to further evaluate patient, institutional, and system-level factors that may red... | yes |
24695920 | Does anterior laxity of the uninjured knee influence clinical outcomes of ACL reconstruction? | [
"The purpose of this study was to evaluate the association between the postoperative outcomes of anterior cruciate ligament (ACL) reconstruction and the anterior laxity of the uninjured knee.",
"We retrospectively reviewed 163 patients who had undergone unilateral ACL reconstruction from January 2002 to August 20... | Greater anterior laxity of the uninjured knee was associated with poorer stability and functional outcomes after ACL reconstruction. Excessive anterior laxity of the uninjured knee thus appears to represent a risk factor for inferior outcomes. | yes |
15466981 | Prostate-specific antigen and free prostate-specific antigen in the early detection of prostate cancer: do combination tests improve detection? | [
"The combined use of free and total prostate-specific antigen (PSA) in early detection of prostate cancer has been controversial. This article systematically evaluates the discriminating capacity of a large number of combination tests.",
"Free and total PSA were analyzed in stored serum samples taken prior to dia... | Tests combining total and percent free PSA show modest overall improvements over total PSA. However, utilization of percent free PSA below a PSA threshold of 4 ng/mL could translate into a practically important reduction in unnecessary biopsies without sacrificing cancers detected. | yes |
18603989 | Can homemade alcohol (Raksi) be useful for preserving dead bodies? | [
"Embalming is the through disinfection and art of preserving bodies after death using chemical substances. It keeps a body life like in appearance during the time it lies in a state prior to funeral.",
"This study was undertaken to investigate the effectiveness of Raksi in sacrificed rats in arresting postmortem ... | It is concluded from the study that this knowledge if applied to dead human subjects, may preserve dead bodies temporarily allowing delayed funeral. | yes |
25150098 | Can common carotid intima media thickness serve as an indicator of both cardiovascular phenotype and risk among black Africans? | [
"It is not known whether common carotid intima media thickness (CIMT) can serve as a surrogate marker of cardiovascular risk among black Africans. Therefore, we examined whether CIMT differed significantly among individuals with distinct cardiovascular phenotype and correlated significantly with traditional cardiov... | Our findings support CIMT as a significant indicator of both cardiovascular risk and phenotype among adult black Africans. However, specific thresholds need to be defined based on prospective studies. | yes |
20337874 | Delayed diagnosis of anorectal malformations: are current guidelines sufficient? | [
"Infants referred to our institution with a final diagnosis of ARM were retrospectively reviewed between 2001 and 2009. The first cohort consisted of patients that were referred between November 2001 and November 2006 with the diagnosis of an ARM that had been delayed for more than 48 h. The second cohort was those... | Delayed diagnosis of an ARM appears to be common, occurring in approximately 32% of patients referred to our institution over the last 2.5 years. Current guidelines appear insufficient to ensure prompt diagnosis of ARM. | no |
19198736 | Is being small for gestational age a risk factor for retinopathy of prematurity? | [
"To analyze prevalence and risk factors for retinopathy of prematurity (ROP) among preterm infants born small for gestational age (SGA) and appropriate for gestational age (AGA).",
"A prospective cohort study included preterm infants with birth weight (BW)<or = 1,500 grams and gestational age (GA)<or = 32 weeks, ... | This study has shown that being SGA was not a significant risk factor for any stage ROP or for severe ROP in this cohort and, also, that the risk factors for ROP were similar among SGA and AGA very-low-birth-weight preterm babies. | no |
22411435 | Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics? | [
"Infliximab, a chimeric monoclonal anti-TNFα antibody, has been found to increase the risk of serious infections compared with the TNF receptor fusion protein etanercept in some studies. It is unclear whether the risk varies by patient characteristics. We conducted a study to address this question.",
"We identifi... | An increased risk of serious infections associated with infliximab relative to etanercept did not appear to be modified by patients' sex, race/ethnicity, body mass index, or smoking status. There was an indication that the increased risk might be limited to patients<65 years. Additional studies are warranted to verify ... | yes |
23792130 | Can magnetic resonance-ultrasound fusion biopsy improve cancer detection in enlarged prostates? | [
"Patients with an enlarged prostate and suspicion of prostate cancer pose a diagnostic dilemma. The prostate cancer detection rate of systematic 12-core transrectal ultrasound guided biopsy is between 30% and 40%. For prostates greater than 40 cc this decreases to 30% or less. Magnetic resonance-ultrasound fusion b... | Transrectal ultrasound guided and fusion biopsy cancer detection rates decreased with increasing prostate volume. However, magnetic resonance-ultrasound fusion biopsy had a higher prostate cancer detection rate compared to that of transrectal ultrasound guided biopsy in the literature. Magnetic resonance-ultrasound fus... | yes |
17462393 | Does normothermic normokalemic simultaneous antegrade/retrograde perfusion improve myocardial oxygenation and energy metabolism for hypertrophied hearts? | [
"Beating-heart valve surgery appears to be a promising technique for protection of hypertrophied hearts. Normothermic normokalemic simultaneous antegrade/retrograde perfusion (NNSP) may improve myocardial perfusion. However, its effects on myocardial oxygenation and energy metabolism remain unclear. The present stu... | Normothermic normokalemic simultaneous antegrade/retrograde perfusion did not improve, but slightly impaired myocardial oxygenation and energy metabolism of beating hypertrophied hearts relative to NNAP. Therefore, NNSP for protection of beating hypertrophied hearts during valve surgery should be used with extra cautio... | no |
21457946 | Are there progressive brain changes in schizophrenia? | [
"It is well established that schizophrenia is associated with structural brain abnormalities, but whether these are static or progress over time remains controversial.",
"A systematic review of longitudinal volumetric studies using region-of-interest structural magnetic resonance imaging in patients with schizoph... | These findings suggest that schizophrenia is associated with progressive structural brain abnormalities, affecting both gray and white matter. We found no evidence to suggest progressive medial temporal lobe involvement but did find evidence that this may be partly explained by heterogeneity between studies in patient ... | yes |
26383908 | Does concept mapping enhance learning outcome of nursing students? | [
"This quasi-experimental study was conducted using a crossover design among two groups of total 64 nursing students. Participants were asked to create concept maps (group A) or were evaluated with the traditional method of quiz (group B) for eight weeks and then take a cumulative test (no. 1). Consequently, subject... | In conclusion, concept mapping has a positive effect on students' academic achievement. These findings could provide valuable evidence for establishing concept mapping as a continuous teaching strategy for nursing students. | yes |
18251357 | Does histologic chorioamnionitis correspond to clinical chorioamnionitis? | [
"To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother.",
"A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnionitis from 2,0... | Histologic chorioamnionitis is a reliable indicator of infection whether or not it is clinically apparent. | yes |
19648304 | Does sonographic needle guidance affect the clinical outcome of intraarticular injections? | [
"This randomized controlled study addressed whether sonographic needle guidance affected clinical outcomes of intraarticular (IA) joint injections.",
"In total, 148 painful joints were randomized to IA triamcinolone acetonide injection by conventional palpation-guided anatomic injection or sonographic image-guide... | Sonographic needle guidance significantly improves the performance and outcomes of outpatient IA injections in a clinically significant manner. | yes |
23222920 | Pancreas retransplantation: a second chance for diabetic patients? | [
"If pancreas transplantation is a validated alternative for type 1 diabetic patients with end-stage renal disease, the management of patients who have lost their primary graft is poorly defined. This study aims at evaluating pancreas retransplantation outcome.",
"Between 1976 and 2008, 569 pancreas transplantatio... | Pancreas retransplantation is a safe procedure with acceptable graft survival that should be proposed to diabetic patients who have lost their primary graft. | yes |
19322056 | Does the enteral feeding advancement affect short-term outcomes in very low birth weight infants? | [
"Controversy exists regarding the optimal enteral feeding regimen of very low birth weight infants (VLBW). Rapid advancement of enteral feeding has been associated with an increased rate of necrotizing enterocolitis. In contrast, delaying enteral feeding may have unfavorable effects on nutrition, growth, and neurod... | Center differences in enteral feeding advancement occur and may have a significant impact on short-term outcomes such as nosocomial sepsis. Large, multicenter, prospective trials are required to further elucidate the optimal feeding strategy for VLBW infants. | yes |
9363529 | Does psychological distress predict disability? | [
"To evaluate psychological distress as a predictor of disability due to common chronic disorders.",
"A 10-year follow-up study was carried out among a representative cohort (N = 8655) of 18-64 year old Finnish farmers, who had participated in a health survey in 1979 and were able to work at baseline. A record lin... | Psychological distress is an independent risk factor for disability. Its predictive significance varies between disorders leading to functional deterioration. The association mechanisms are likely to vary from one disorder to another. | yes |
15962678 | Does preloading with colloids prevent hemodynamic changes when neurosurgical patients are subsequently changed to the seated position? | [
"This prospective, randomized, double-blind study was designed to determine and compare the usefulness of preloading colloids (Haemaccel) 10 ml/Kg before positioning whether it can prevent hemodynamic changes during seated positioning or not.",
"The authors studied 20 patients by randomly dividing them into 2 gro... | It is concluded that preloading colloid fluid prior to repositioning could prevent the decrease of systolic blood pressure and central venous pressure during sitting positioning without other complications. | yes |
24235894 | Is there a first night effect on sleep bruxism? | [
"Sleep bruxism (SB) is reported to vary in frequency over time. The aim of this study was to assess the first night effect on SB.",
"A retrospective polysomnographic (PSG) analysis was performed of data from a sample of SB patients (12 females, 4 males; age range: 17-39 years) recorded in a sleep laboratory over ... | The results showed no overall first night effect on severity of RMMA frequency in young and healthy patients with SB. In clinical practice, one-night sleep recording may be sufficient for moderate-high frequency SB patients. However, low RMMA frequency in the first night could be confirmed by a second night based on th... | no |
17429333 | Does menopausal transition affect the quality of life? | [
"The aim of this study was to investigate the role of menopausal transition and menopausal symptoms in relation to quality of life in a cohort of middle-aged women in Kinmen.",
"A total of 734 premenopausal women participated in the baseline study, and 579 women (78.9%) completed a follow-up 2 years later. Qualit... | This longitudinal study found no significant effect of menopausal transition on quality of life among Taiwanese women. The decline in the role limitations due to emotional problems was related to vasomotor symptoms. | no |
19156007 | Can clinicians use the PHQ-9 to assess depression in people with vision loss? | [
"To investigate whether the Patient Health Questionnaire-9 (PHQ-9) possesses the essential psychometric characteristics to measure depressive symptoms in people with visual impairment.",
"The PHQ-9 scale was completed by 103 participants with low vision. These data were then assessed for fit to the Rasch model.",... | Our findings demonstrate that the PHQ-9, when scaled with Rasch analysis, forms a linear interval measurement of depressive symptoms suitable for use in a vision impaired population. | yes |
25981682 | Preparing patients at high risk of falls for discharge home after rehabilitation: Do we meet the guidelines? | [
"Medical records of 121 people who received inpatient rehabilitation were retrospectively screened; records of 50 people discharged home and at high falls risk (fall in last 12 months, fall preceding/during admission) were audited. Data extracted included falls risk identification during rehabilitation and in disch... | There was little evidence that people at high risk of falls received systematic falls risk assessment during rehabilitation. When a risk was identified, generally a strategy was implemented. However, failure to assess some risk factors might have limited fall prevention strategies offered. Failure to adequately address... | no |
22205377 | Some aspects of social exclusion: do they influence suicide mortality? | [
"The current study is aimed to assess the relationship between the 'economic/employment' and 'social/welfare' dimensions of social exclusion and suicide mortality in Europe.",
"Suicide rates for 26 countries were obtained from the WHO. Data on social expenditure were obtained from the OECD database. Employment ra... | Both 'economic/employment' and 'social/welfare' dimensions of social exclusion significantly influence suicide mortality among males. The influence of 'economic/employment' and 'social/welfare' dimensions of social exclusion on female suicide mortality is controversial. Social exclusion might be considered as a risk fa... | yes |
16241924 | Does parity increase insulin resistance during pregnancy? | [
"To study the effect of parity on impairment of insulin sensitivity during pregnancy and on the risk of gestational diabetes (GDM).",
"We studied the relationship between parity and peripheral insulin sensitivity index (ISI(OGTT)) or GDM in 1880 caucasian women, who underwent a 100-g, 3-h oral glucose tolerance t... | Parity is not directly linked to insulin sensitivity deterioration, to CP/FPG increase during pregnancy, or to GDM appearance, although it is linked through the mediation of progressive ageing and weight gain either before or during pregnancy, when there is a sufficiently long time interval between pregnancies. | no |
24599411 | Is gastric cancer different in Korea and the United States? | [
"To compare the characteristics and prognoses of gastric cancers by tumor location in Korean and U.S. subjects after curative-intent (R0) resection for gastric cancer (GC).",
"Data were collected for all patients who had undergone R0 resection at one U.S. institution (n = 567) and one South Korean institution (n ... | There were significant differences in tumor characteristics by tumor location within and between both national cohorts. On the basis of these findings, further study to investigate the biological difference between the two countries is needed. | yes |
23860049 | Do we need imaging to diagnose appendicitis in children? | [
"To evaluate the role of clinical assessment with selective use of imaging studies in the management of suspected acute appendicitis in children.",
"Medical records of children referred to Emergency Room in 2010 for suspected appendicitis were retrospectively reviewed. Diagnostic investigations divided by age and... | Clinical assessment is the key to diagnose appendicitis. Nevertheless, in girls older than 10 years, selected use of imaging should be implemented to avoid unnecessary appendectomies. Imaging of choice in equivocal cases should be ultrasonography. | maybe |
26133538 | Does oral α-galactosidase relieve irritable bowel symptoms? | [
"Abdominal bloating is reported by a majority of irritable bowel syndrome (IBS) patients. Excess colonic fermentation may cause gaseous symptoms. Several foodstuffs contain oligosaccharides with an α-galactosidic linkage that is resistant to mammalian hydrolases. Assisted hydrolysis by exogenous α-galactosidase enz... | We found no evidence to support the use of AG routinely in IBS patients. Improvement of clinical response at 4-week follow-up may suggest a long-term effect of unknown mechanism, but could also be attributed to non-responder drop out. Gastrointestinal (GI) side effects may be a coincidence in this study, but irritation... | no |
23088164 | Does cognitive function predict frequency compressed speech recognition in listeners with normal hearing and normal cognition? | [
"The aim was to investigate the relationship between cognitive ability and frequency compressed speech recognition in listeners with normal hearing and normal cognition.",
"Speech-in-noise recognition was measured using Institute of Electrical and Electronic Engineers sentences presented over earphones at 65 dB S... | The relationship between cognitive functioning and recognition of frequency compressed speech-in-noise was not statistically significant. The findings may have been different if the participants had been provided with training and/or time to 'acclimatize' to the frequency-compressed conditions. | no |
22658587 | Affect-regulated exercise intensity: does training at an intensity that feels 'good' improve physical health? | [
"Affect-regulated exercise to feel 'good' can be used to control exercise intensity amongst both active and sedentary individuals and should support exercise adherence. It is not known, however, whether affect-regulated exercise training can lead to physical health gains. The aim of this study was to examine if aff... | Affect-regulated exercise to feel 'good' can be used in a training programme to regulate exercise intensity. This approach led to a 19% increase in time to reach ventilatory threshold, which is indicative of improved fitness. | yes |
16361634 | Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? | [
"Lynch syndrome (hereditary nonpolyposis colorectal cancer; HNPCC) is an autosomal-dominant cancer predisposition syndrome that increases risk for multiple cancers, including colon, endometrial, and ovarian cancer. Revised Bethesda Criteria recommend that patients with two HNPCC-associated cancers undergo molecular... | Overall, 7% of women in our cohort met either clinical or molecular criteria for Lynch syndrome. All of these women had a prior history or a first-degree relative with an HNPCC-associated cancer. Limiting genetic evaluation to women with synchronous endometrial and ovarian cancer who have a family history suggestive of... | maybe |
23449952 | Contrast-enhanced MR imaging of hand and finger joints in patients with early rheumatoid arthritis: do we really need a full dose of gadobenate dimeglumine for assessing synovial enhancement at 3 T? | [
"To investigate the diagnostic value of a half dose compared with a full dose of gadobenate dimeglumine in the assessment of synovitis or tenosynovitis in the wrist and finger joints in patients with early rheumatoid arthritis (RA) and a disease activity score greater than 3.2.",
"With institutional review board ... | Postcontrast synovial SIs showed high correlation between half dose and full dose, and image quality was rated identically. Therefore, half-dose gadobenate dimeglumine at 3-T MR imaging may be sufficient for assessing synovitis or tenosynovitis in early RA. | no |
10430303 | Does laparoscopic cholecystectomy influence peri-sinusoidal cell activity? | [
"To investigate the influence of laparoscopic procedures on perisinusoidal cell function.",
"In 31 patients who underwent laparoscopic cholecystectomy for symptomatic cholelithiasis, the serum levels of beta-N-acetyl hexosaminidase (beta-NAH) and hyaluronic acid (HA) were measured. Six female patients, who underw... | Laparoscopic procedures caused detectable damage to Kupffer and endothelial cells as reflected by elevation of post-operative HA serum levels. The damage to the liver hepatocytes and perisinusoidal cells has no clinical significance and the laparoscopic procedure itself is the probable cause of the Kupffer and endothel... | yes |
23048048 | Risky sexual behavior among college students With ADHD: is the mother-child relationship protective? | [
"This study examined the extent to which ADHD was associated with risky sexual behaviors (RSBs) in a sample of 92 undergraduates with (n = 44) and without (n = 48) ADHD. Mother-child relationship quality was examined as a potential moderator.",
"We conducted comprehensive assessments for ADHD and comorbid conditi... | Results suggest that female college students with ADHD are at risk for unprotected sex. Moreover, a positive mother-child relationship may be protective for college students with ADHD in relation to RSB. | yes |
16991071 | Rotator cuff tear--an occupational disease? | [
"In literature there are only few data which describe the influence of occupation on the development of rotator cuff disease.",
"In a retrospective study, 760 open rotator cuff repairs were analysed and related to the profession and occupational load. Exclusion criteria were traumatic tears and sports injuries. A... | Our data suggest that working exposure increases the risk or leads to the clinical manifestation of rotator cuff tears. Although a detailed analysis of individual physical exposure is not available yet, the statistical results indicate that rotator cuff tears must be taken into consideration as a result of ergonomic ex... | yes |
24614851 | Prognostic factors for cervical spondylotic amyotrophy: are signs of spinal cord involvement associated with the neurological prognosis? | [
"The purpose of this study was to clarify the prognostic factors for cervical spondylotic amyotrophy (CSA).",
"The authors retrospectively reviewed the medical records of 47 consecutive patients with CSA in whom the presence/absence of the pyramidal tract sign was noted. We analyzed whether the age, sex, presence... | The presence of a high signal intensity change on T2-weighted MRI and the pyramidal tract sign can be used as prognostic factors for patients with CSA. | yes |
17578985 | Parasacral sciatic nerve block: does the elicited motor response predict the success rate? | [
"In this prospective, randomized, double-blind study, we compared the tibial and the peroneal evoked motor response with regard to efficacy of sciatic nerve block using the parasacral approach.",
"Twenty-six ASA I-III patients scheduled for elective lower limb surgery were randomized to receive a parasacral sciat... | Eliciting a tibial motor response predicts a higher success rate than eliciting a peroneal motor response with parasacral sciatic nerve block. | maybe |
15137012 | Ovarian torsion in children: is oophorectomy necessary? | [
"Most pediatric surgeons perform oophorectomy in girls presenting with ovarian torsion in which the ovary appears necrotic. However, the adult gynecology literature suggests that many ovaries can be treated by detorsion alone.",
"All children with ovarian torsion on the gynecology and general surgery services bet... | Simple detorsion was not accompanied by an increase in morbidity, and all patients studied had functioning ovarian tissue on follow-up despite the surgeon's assessment of the degree of ovarian ischemia. Detorsion is the procedure of choice for most cases of ovarian torsion in children. | no |
15787677 | Does aerobic fitness influence microvascular function in healthy adults at risk of developing Type 2 diabetes? | [
"Twenty-seven healthy normal glucose-tolerant humans with either a previous diagnosis of gestational diabetes or having two parents with Type 2 diabetes and 27 healthy adults who had no history of diabetes were recruited. Maximal oxygen uptake was assessed using an incremental exercise test to exhaustion. Skin micr... | In this 'at-risk' group with skin microvascular dysfunction maximal oxygen uptake was not reduced compared with healthy controls. However, in the 'at-risk' group alone, individuals with higher levels of aerobic fitness also had better microvascular and endothelial responsiveness. | maybe |
25304452 | Nutritional assessment of gluten-free diet. Is gluten-free diet deficient in some nutrient? | [
"The gluten-free diet has traditionally been accepted as a healthy diet, but there are articles advocating that it may have some nutritional deficiencies. The current study assesses whether there was any change in the contributions of calories, essential elements, proportion of fatty acids, vitamins, minerals and f... | The gluten-free diet has minimal deficiencies, similar to those present in the diet with gluten, with an improvement in the lipid profile by increasing the proportion of monounsaturated fatty acids to the detriment of saturated fatty acids. | yes |
19711462 | Standardizing care in medical oncology: are Web-based systems the answer? | [
"Medical oncology is embracing information technology to standardize care and improve patient outcomes, with a range of Web-based systems used internationally. The authors' aim was to determine the factors affecting the uptake and use of a Web-based protocol system for medical oncology in the Australian setting.",
... | Although the provision of high-quality evidence-based resources, electronic or otherwise, is essential for standardizing care and improving patient outcomes, the authors' findings demonstrate that this alone does not ensure uptake. It is important to understand end-users, the environment in which they operate, and the ... | maybe |
12855939 | Is ankle/arm pressure predictive for cardiovascular mortality in older patients living in nursing homes? | [
"longitudinal descriptive study.",
"2 large nursing homes in Turin, Italy.",
"418 dependent elderly (83 males, 335 females, mean age 83.7+/-8.5 y, range 55-102) living in the nursing homes.",
"the prevalence of peripheral arterial disease (PAD) was evaluated using a Doppler Ultrasound measurement of AAI (Ankl... | The prevalence of PAD is high in nursing home residents. AAI is not predictive for IHD mortality in this population. In very frail elderly traditional risk factors and PAD are less important predictors of death compared to poor functional status, nutritional factors and previous cardiovascular disease. | no |
24606627 | The objective structured clinical examination: can physician-examiners participate from a distance? | [
"Currently, a 'pedagogical gap' exists in distributed medical education in that distance educators teach medical students but typically do not have the opportunity to assess them in large-scale examinations such as the objective structured clinical examination (OSCE). We developed a remote examiner OSCE (reOSCE) th... | This preliminary study demonstrated that OSCE ratings by LEs and REs were reasonably comparable when using checklists. Remote examination may be a feasible and acceptable way of assessing students' clinical skills, but further validity evidence will be required before it can be recommended for use in high-stakes examin... | yes |
23386371 | CPAP therapy in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea: does it offer a better quality of life and sleep? | [
"The recent literature shows an increased incidence of obstructive sleep apnea (OSA) in patients with idiopathic pulmonary fibrosis (IPF). On the other hand, there are no published studies related to continuous positive airway pressure (CPAP) treatment in this patient group. Our aim was to assess the effect of CPAP... | Effective CPAP treatment in IPF patients with OSA results in a significant improvement in daily living activities based on the FOSQ, namely an OSA-specific follow-up instrument. Improvement was also noted in other questionnaires assessing quality of life, though not to a statistically significant degree, probably becau... | maybe |
9569972 | Proliferative index obtained by DNA image cytometry. Does it add prognostic information in Auer IV breast cancer? | [
"To investigate whether the S + G2/M fraction (proliferative index) is a prognostic determinant in breast cancers classified as Auer IV.",
"Prognostic evaluation of Auer IV DNA histograms with respect to the high versus low S + G2/M fraction, obtained by image cytometry on consecutive breast cancer imprint prepar... | According to ICM-DNA values corresponding to the S + G2/M region, patients with breast cancers classified as Auer IV can be divided into subgroups with different tumor characteristics and prognoses. | yes |
25406780 | Does skin care frequency affect the severity of incontinence-associated dermatitis in critically ill patients? | [
"Incontinence-associated dermatitis (IAD) is a potentially serious skin injury that can lead to pressure ulcers (PUs). Multiple studies have indicated the need for evidence to find the most effective skin care protocol to reduce the incidence and severity of IAD in critically ill patients.",
"To compare the incid... | The researchers studied a defined skin care protocol using a cleanser with aloe vera and a cleansing lotion, followed by application of either a moisture barrier with silicone or skin protectant with zinc oxide and menthol, undertaken at two different frequencies. Data revealed the incidence of moderate IAD was decreas... | yes |
27884344 | Do resident's leadership skills relate to ratings of technical skill? | [
"This study sought to compare general surgery research residents' survey information regarding self-efficacy ratings to their observed performance during a simulated small bowel repair. Their observed performance ratings were based on their leadership skills in directing their assistant.",
"Participants were give... | General surgery research residents' intraoperative leadership skills showed significant correlations to their perceptions of skill decay and task difficulty during a bowel repair. Evaluating resident's directional instructions may provide an additional individualized intraoperative assessment metric. Further evaluation... | yes |
18800356 | The FOOTSTEP self-management foot care programme: are rheumatoid arthritis patients physically able to participate? | [
"The FOOTSTEP self-management foot care programme is a clinical and cost-effective programme for basic foot care in the elderly. The aim of this study was to determine if patients with rheumatoid arthritis (RA) would be physically able to participate.",
"A consecutive cohort of RA patients undergoing podiatry car... | Just over half the patients in this present cohort may be physically able to undertake some aspects of self-managed foot care, including nail clipping and filing, callus filing and daily hygiene and inspection. | maybe |
22301406 | CYP2D6*4 allele and breast cancer risk: is there any association? | [
"CYP2D6 is an important cytochrome P450 enzyme. These enzymes catalyse the oxidative biotransformation of about 25% of clinically important drugs as well as the metabolism of numerous environmental chemical carcinogens. The most frequent null allele of CYP2D6 in European populations, CYP2D6*4, has been studied here... | A possible decreased transformation of procarcinogens by CYP2D6*4 poor metabolisers could result in a protective effect against carcinogens. | yes |
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