id stringlengths 6 8 | question stringlengths 17 664 | context listlengths 1 12 | response stringlengths 1 3.12k | answer stringclasses 3
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26079501 | Does base deficit predict mortality in patients with severe traumatic brain injury? | [
"Base Deficit (BD) is a marker of tissue hypoxia in polytrauma patients. It guides resuscitative measures, and predicts outcomes, complications and mortality. The aim of this study was to examine the presence of BD in patients with isolated severe traumatic brain injury (TBI), and to assess if it correlates with th... | Although BD is correlated with GCS at presentation and RTS, it is not a reliable prognostic marker for outcome and mortality in patients with isolated TBI. | no |
11713724 | Cancer of the buccal mucosa: are margins and T-stage accurate predictors of local control? | [
"Cancer of the buccal mucosa is an uncommon and aggressive neoplasm of the oral cavity. Less than 2% of patients treated for cancer of the oral cavity at Roswell Park Cancer Institute (RPCI) from 1971 to 1997 had primary buccal cancers. Because the majority of these patients did not undergo any adjuvant treatment, ... | Local excision of T1 and T2 buccal mucosa cancers with pathologically negative margins had a high rate of local recurrence in our series. Low T-stage and negative margins are not adequate predictors of local control. Even early buccal tumors may benefit from adjuvant therapy to enhance local control. | no |
25070942 | Can mass drug administration lead to the sustainable control of schistosomiasis? | [
"In the Philippines, the current national control strategy for schistosomiasis is annual mass drug administration (MDA) with 40 mg/kg of praziquantel in all schistosomiasis-endemic villages with a prevalence ≥10%.",
"A cross-sectional survey of schistosomiasis was conducted in 2012 on 18 221 individuals residing ... | MDA on its own was insufficient to control the prevalence of schistosomiasis, intensity of Schistosoma infection, or morbidity of the disease. Alternative control measures will be needed to complement the existing national MDA program. | no |
19683101 | Can D-dimer become a new diagnostic parameter for acute appendicitis? | [
"In this study, we investigated D-dimer serum level as a diagnostic parameter for acute appendicitis.",
"Forty-nine patients were enrolled in the study. Patients were classified according to age; sex; duration between the beginning of pain and referral to a hospital or clinic; Alvarado scores; and in physical exa... | Increased D-dimer levels should not be considered as a diagnostic parameter in diagnosis of acute appendicitis. | no |
10783841 | Is there a relationship between rheumatoid arthritis and periodontal disease? | [
"1,412 individuals attending the University of Queensland's School of Dentistry were assessed for the prevalence of periodontal disease and rheumatoid arthritis. Analysis of data obtained from a self-reported health questionnaire and dental records was carried out and included: number of individuals referred for ad... | Based on data derived from self-reported health conditions, and not withstanding the limitations of such a study, we conclude that there is good evidence to suggest that individuals with moderate to severe periodontal disease are at higher risk of suffering from rheumatoid arthritis and vice versa. | yes |
19406119 | Does telmisartan prevent hepatic fibrosis in rats with alloxan-induced diabetes? | [
"This study evaluated the effect of telmisartan on the livers of diabetic rats and also aimed to determine the hepatic distribution and role of transforming growth factor beta (TGF-beta) in diabetes-related hepatic degeneration while taking into account the possible protective effects of telmisartan.",
"Fifteen a... | Results suggest that telmisartan may reduce type-I diabetes mellitus-induced hepatic injury by suppressing activated hepatic stellate cells through concomitant TGF-beta1 down-regulation. | yes |
19058191 | Is there a discrepancy between patient and physician quality of life assessment? | [
"Quality of Life (QoL) assessment remains integral in the investigation of women with lower urinary tract dysfunction. Previous work suggests that physicians tend to underestimate patients' symptoms and the bother that they cause. The aim of this study was to assess the relationship between physician and patient as... | This study confirms that physicians often differ from patients in the assessment of QoL. This is most likely due to a difference in patient-physician perception of "significant" LUTS and clearly demonstrates the importance of patient evaluated QoL in routine clinical assessment. | yes |
17312514 | Does quilting suture prevent seroma in abdominoplasty? | [
"Seroma is the most frequent complication in abdominoplasty. Some patients are more prone to develop this complication. Ultrasound is a well-known method with which to diagnose seroma in the abdominal wall. The purpose of this study was to verify the efficacy of the use of quilting suture to prevent seroma.",
"Tw... | The quilting suture seems to be an efficient technique with which to prevent seroma formation. | yes |
23002947 | Does feeding tube insertion and its timing improve survival? | [
"To examine survival with and without a percutaneous endoscopic gastrostomy (PEG) feeding tube using rigorous methods to account for selection bias and to examine whether the timing of feeding tube insertion affected survival.",
"Prospective cohort study.",
"All U.S. nursing homes (NHs).",
"Thirty-six thousan... | Neither insertion of PEG tubes nor timing of insertion affect survival. | no |
23453079 | Does prostate morphology affect outcomes after holmium laser enucleation? | [
"To determine whether prostate morphology or technique used has any effect on postoperative outcomes after holmium laser enucleation of the prostate.",
"A retrospective review of prospectively collected data was completed for all patients undergoing a holmium laser enucleation of the prostate at our institution. ... | Those patients with trilobar prostate morphology are more likely to achieve a greater decrease in the PVR urine volume after holmium laser enucleation of the prostate. All other outcomes appeared to be similar between the 2 groups. In addition, a 2-lobe technique can be safely used for trilobar prostates when deemed fe... | yes |
21368683 | Are patients with serious mental illness more likely to be admitted to nursing homes with more deficiencies in care? | [
"Patients diagnosed with serious mental illness (SMI) who qualify for nursing home placement tend to require high levels of both psychiatric and nursing care. However, it is unknown whether they are equally likely to be admitted to nursing homes with adequate quality of care compared with other patients.",
"We an... | Patients diagnosed with schizophrenia or bipolar disorder (ie, SMI) were more likely than other patients to be admitted to nursing homes with higher deficiency citations for both overall quality and clinical care quality. Further research is necessary to understand the reasons behind the disparity in quality of nursing... | yes |
27832831 | Does an additional antirotation U-Blade (RC) lag screw improve treatment of AO/OTA 31 A1-3 fractures with gamma 3 nail? | [
"Poor bone quality and unstable fractures increase the cut-out rate in implants with gliding lag screws. The U-Blade (RC) lag screw for the Gamma3®nail was introduced to provide monoaxial rotational stability of the femoral head and neck fragment. The purpose of this study was to evaluate whether the use of the U-B... | In our study the U-Blade (RC) lag screw did not reduce the cut-out in treatment of OTA/AO 31A1-3 fractures at all. Considering the longer duration of surgery and the higher costs of the U-Blade (RC) lag screw, our results do not justify its use. However, further prospective randomized studies will be necessary. | no |
24958650 | May mean platelet volume levels be a predictor in the diagnosis of pelvic inflammatory disease? | [
"Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID).",
"Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the clinic for ... | Since the MPV value was significantly decreased in patients with PID, it may serve as an additional and even more valuable marker than leukocyte count in the diagnosis of PID. | yes |
9278754 | Are head and neck specific quality of life measures necessary? | [
"The purpose of this study was to determine whether head and neck-specific health status domains are distinct from those assessed by general measures of quality-of-life (QOL).",
"Cross-sectional study of 55 head and neck cancer patients in tertiary academic center was made. Three head and neck-specific measures,-... | Head and neck-specific QOL measures are necessary and should include domains that reflect ES, SC, and AP. | yes |
26999038 | Could chest wall rigidity be a factor in rapid death from illicit fentanyl abuse? | [
"There has been a significant spike in fentanyl-related deaths from illicit fentanyl supplied via the heroin trade. Past fentanyl access was primarily oral or dermal via prescription fentanyl patch diversion. One factor potentially driving this increase in fatalities is the change in route of administration. Rapid ... | In summary we believe sudden onset chest wall rigidity may be a significant and previously unreported factor leading to an increased mortality, from illicit IV fentanyl use. Fentanyl and norfentanyl ratios and concentrations suggest a more rapid onset of death given the finding of fentanyl without norfentanyl in many o... | yes |
23598835 | Is severe pain immediately after spinal augmentation a predictor of long-term outcomes? | [
"Severe, immediate postprocedural pain and the need for analgesics after vertebroplasty can be a discouraging experience for patients and caregivers. The goal of this study was to investigate whether the presence of severe pain immediately after vertebroplasty predicts short- and long-term pain relief.",
"A chart... | Patients with severe pain immediately after vertebroplasty have similar long-term outcomes compared with patients without severe pain. | no |
17890090 | Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? | [
"The aim of this study was to determine whether bone scans (BS) can be avoided if pelvis was included in CT thorax and abdomen to detect bony metastases from breast cancer.",
"Results of 77 pairs of CT (thorax, abdomen, and pelvis) and BS in newly diagnosed patients with metastatic breast cancer (MBC) were compar... | Our findings suggest routine BS of patients presenting with MBC is not required if CT (thorax, abdomen, and pelvis) is performed. | yes |
22813804 | Does obesity impact the pattern and outcome of trauma in children? | [
"Childhood obesity is pandemic condition. The effect of obesity on trauma outcomes in children has been relatively understudied. We conducted this study to ascertain the effects of obesity on the hospital outcome of injured children.",
"A retrospective cohort study of patients aged 2 to 18 years admitted to the K... | Obesity does not seem to impact the severity of injury, mortality rate, types of injury, and procedure outcomes in children. Obese patients are more likely to have rib and pelvic injuries. | no |
20304513 | Is (18)F-FDG a surrogate tracer to measure tumor hypoxia? | [
"Fluorodeoxyglucose (FDG) has been reported as a surrogate tracer to measure tumor hypoxia with positron emission tomography (PET). The hypothesis is that there is an increased uptake of FDG under hypoxic conditions secondary to enhanced glycolysis, compensating the hypoxia-induced loss of cellular energy productio... | This study showed that FDG is not a good surrogate tracer for tumor hypoxia under either ambient or hypoxic conditions. Only specific hypoxia tracers should be used to measure tumor hypoxia. | no |
10811329 | Are 99mTc leukocyte scintigraphy and SBFT studies useful in children suspected of having inflammatory bowel disease? | [
"The goal of this retrospective study was to assess whether 99mTc-white blood cell (WBC) scintigraphy and upper gastrointestinal small bowel follow-through (UGI-SBFT) could exclude inflammation in children suspected of having inflammatory bowel disease (IBD).",
"Of a population of 313 children who had a 99mTc-WBC... | Our results suggest that 99mTc-WBC is useful as an initial screening modality to exclude IBD, and is more sensitive than UGI-SBFT studies. | yes |
27909738 | Prostate bed target interfractional motion using RTOG consensus definitions and daily CT on rails : Does target motion differ between superior and inferior portions of the clinical target volume? | [
"Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differ... | There are no statistically apparent motion differences between SUP-CTV and INF-CTV. Current uniform planning target volume (PTV) margins are adequate to cover both portions of the CTV. | no |
26063028 | Esophagogastric devascularization without splenectomy in portal hypertension: safe and effective? | [
"Esophagogastric variceal hemorrhage is a life-threatening complication of portal hypertension. In this study, we compared the therapeutic effect of a novel surgical procedure, esophagogastric devascularization without splenectomy (EDWS), with the widely used modified esophagogastric devascularization (MED) with sp... | EDWS is a safe and effective treatment for esophagogastric varices secondary to portal hypertension in selected patients. Patients treated with EDWS had a lower complication rate of portal venous system thrombosis compared with those treated with conventional MED. | yes |
25034219 | Does maternal obesity have an influence on feeding behavior of obese children? | [
"Obese children and adolescents referred to the pediatric endocrinology department were enrolled consecutively. Height and weight of all children and their mothers were measured. Maternal feeding practices were measured using an adapted version of the Child Feeding Questionnaire (CFQ). Answers were compared between... | Mothers' BMI highly correlate with children's BMI-z-scores. The degree of child's obesity increases mothers' concern and food restriction behavior. While mothers of obese children have a high prevalence of obesity, maternal obesity was found to have no significant influence on feeding behavior of obese school children. | no |
27908583 | Should lower limb fractures be treated surgically in patients with chronic spinal injuries? | [
"To report the outcomes of surgical treatment of lower limb fractures in patients with chronic spinal cord injuries.",
"A total of 37 lower limb fractures were treated from 2003 to 2010, of which 25 fractures were treated surgically and 12 orthopaedically.",
"Patients of the surgical group had better clinical r... | Chronic spinal cord injuries patients with lower limb fractures who are treated surgically achieved a more reliable consolidation, practically a free range of motion, low rate of cutaneous complications, and pain associated with the fracture. This allows a quick return to the previous standard of living, and should be ... | yes |
11500608 | Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms? | [
"Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole.STUDY: Sixty-two patients (19 men and 43 women; mean age, 54 years; range, 32-77 years) with heartburn and regurgitation and norma... | There is no indication of a rebound aggravation of symptoms 12 to 14 days after a 5-day treatment with lansoprazole 60 mg once daily in patients with reflux symptoms. | no |
8111516 | Do family physicians make good sentinels for influenza? | [
"To determine whether volunteer family physician reports of the frequency of influenza-like illness (ILI) usefully supplement information from other influenza surveillance systems conducted by the Centers for Disease Control and Prevention.",
"Evaluation of physician reports from five influenza surveillance seaso... | Family physicians provide sensitive, timely, and accurate community influenza morbidity data that complement data from other surveillance systems. This information enables monitoring of the type, timing, and intensity of influenza activity and can help health care workers implement prevention or control measures. | yes |
25985014 | Is ganglionated plexi ablation during Maze IV procedure beneficial for postoperative long-term stable sinus rhythm? | [
"We investigated the role of surgical ablation targeting the autonomous nervous system during a Cox-Maze IV procedure in the maintenance of sinus rhythm at long-term follow-up.",
"The patient population consisted of 519 subjects with persistent or long-standing persistent atrial fibrillation (AF) undergoing radio... | GP ablation did not prove to be beneficial for postoperative stable NSR. A complete left atrial lesion set and biatrial ablation are advisable for improving rhythm outcomes. Randomized controlled trials are necessary to confirm our findings. | no |
20156655 | Scrotal approach to both palpable and impalpable undescended testes: should it become our first choice? | [
"To determine the advantages of scrotal incision in the treatment of undescended testis. Undescended testis is a common pediatric condition and is conventionally managed surgically by orchidopexy. A single scrotal incision orchidopexy has become accepted as a valid approach for patients with palpable undescended te... | Initial single scrotal incision can be recommended for orchidopexy, even in the more difficult cases of impalpable undescended testes. Advantages seem to include shorter operative time, a cosmetically appealing single incision, and possibly less pain. The scrotal incision technique significantly reduces the need for la... | yes |
16249670 | Does the investing layer of the deep cervical fascia exist? | [
"The placement of the superficial cervical plexus block has been the subject of controversy. Although the investing cervical fascia has been considered as an impenetrable barrier, clinically, the placement of the block deep or superficial to the fascia provides the same effective anesthesia. The underlying mechanis... | This study provides anatomical evidence to indicate that the so-called investing cervical fascia does not exist in the anterior triangle of the neck. Taking the previous reports together, the authors' findings strongly suggest that deep potential spaces in the neck are directly continuous with the subcutaneous tissue. | no |
20101129 | Is prophylactic fixation a cost-effective method to prevent a future contralateral fragility hip fracture? | [
": A previous hip fracture more than doubles the risk of a contralateral hip fracture. Pharmacologic and environmental interventions to prevent hip fracture have documented poor compliance. The purpose of this study was to examine the cost-effectiveness of prophylactic fixation of the uninjured hip to prevent contr... | : Prophylactic fixation with a cephalomedullary nail was not found to be cost-effective for the average older woman who sustained a hip fracture. However, it may be appropriate for select patient populations. The study supports the need for basic science and clinical trials investigating the effectiveness of prophylact... | maybe |
17593459 | Is double-balloon enteroscopy an accurate method to diagnose small-bowel disorders? | [
"The aim of this study was to analyze the contribution of the double-balloon enteroscopy (DBE) for diagnosis of the small bowel disorders.",
"Forty-four patients (20 women, 24 men; mean age 53.5 years-old, range 21-89 years) with chronic gastrointestinal bleeding, diarrhea, polyposis, weight-loss, Roux-en-Y surge... | 1. DBE is a safe and and accurate method to diagnose small bowel disorders; 2. this method permits chromoscopy, biopsies and treatment of the lesions. | yes |
17715311 | Is fetal anatomic assessment on follow-up antepartum sonograms clinically useful? | [
"The purpose of this study was to evaluate the clinical usefulness of a fetal anatomic survey on follow-up antepartum sonograms.",
"A retrospective follow-up study was conducted at a low-risk maternity clinic from July 1, 2005, to June 30, 2006. Eligible women had at least 1 prior sonographic examination beyond 1... | A fetal anatomic survey on follow-up sonograms may identify unanticipated fetal anomalies, especially when the indication is for fetal growth. | yes |
10732884 | Does coronary angiography before emergency aortic surgery affect in-hospital mortality? | [
"To study the relationship between coronary angiography and in-hospital mortality in patients undergoing emergency surgery of the aorta without a history of coronary revascularization or coronary angiography before the onset of symptoms.",
"In the setting of acute ascending aortic dissection warranting emergency ... | These data indicate that determination of coronary anatomy may not impact on survival in patients undergoing emergency surgery of the aorta and support the concept that once diagnosed, patients should proceed as quickly as possible to surgery. | no |
26784147 | Target Serum Urate: Do Gout Patients Know Their Goal? | [
"To examine gout patients' knowledge of their condition, including the central role of achieving and maintaining the serum urate (SU) goal with the use of urate-lowering therapy (ULT).",
"This study of 612 gout patients was conducted at a Veterans Affairs medical center. Gout patients were included based on admin... | There is a knowledge deficit regarding the SU treatment goal among gout patients receiving ULT, despite generally high levels of other gout-specific knowledge. SU goal information may be an important and underutilized concept among providers treating gout patients. | no |
22849512 | Are neighbourhood social capital and availability of sports facilities related to sports participation among Dutch adolescents? | [
"The aim of this study is to explore whether availability of sports facilities, parks, and neighbourhood social capital (NSC) and their interaction are associated with leisure time sports participation among Dutch adolescents.",
"Cross-sectional analyses were conducted on complete data from the last wave of the Y... | The results of this study indicate that leisure time sports participation is associated with levels of NSC, but not with availability of parks or sports facilities. In addition, NSC and availability of parks in the zip code area interacted in such a way that leisure time sports participation is most likely among adoles... | maybe |
17403428 | Recurrent spontaneous abortion and skewed X-inactivation: is there an association? | [
"The purpose of this study was to determine whether there is an association between skewed X-inactivation and recurrent spontaneous abortion in a large, well-defined sample of women with recurrent loss.",
"X-chromosome inactivation patterns were compared in 5 groups of women. Group 1 (recurrent spontaneous aborti... | Skewed X-inactivation is not associated with recurrent spontaneous abortion but is associated with increasing maternal age. | no |
17551944 | Doppler examination of uteroplacental circulation in early pregnancy: can it predict adverse outcome? | [
"To determine whether spectral Doppler measurements obtained from bilateral uterine, arcuate, radial, and spiral arteries in early gestation correlate with adverse pregnancy outcome.",
"One hundred five pregnant women underwent transvaginal Doppler sonographic examination of uteroplacental circulation at 6-12 wee... | Transvaginal Doppler examination can detect hemodynamic changes in uteroplacental circulation associated with subsequent adverse pregnancy outcome. | yes |
17606778 | Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? | [
"Complex regional pain syndrome type I is treated symptomatically. A protective effect of vitamin C (ascorbic acid) has been reported previously. A dose-response study was designed to evaluate its effect in patients with wrist fractures.",
"In a double-blind, prospective, multicenter trial, 416 patients with 427 ... | Vitamin C reduces the prevalence of complex regional pain syndrome after wrist fractures. A daily dose of 500 mg for fifty days is recommended. | yes |
26044262 | Are income-related differences in active travel associated with physical environmental characteristics? | [
"Rates of active travel vary by socio-economic position, with higher rates generally observed among less affluent populations. Aspects of both social and built environments have been shown to affect active travel, but little research has explored the influence of physical environmental characteristics, and less has... | The socio-economic gradient in active travel seems independent of physical environmental characteristics. Whilst more affluent populations enjoy advantages on some health outcomes, they will still benefit from increasing their levels of physical activity through active travel. Benefits of active travel to the whole com... | no |
20011163 | Can Roux-en-Y gastric bypass provide a lifelong solution for diabetes mellitus? | [
"The surgical treatment of diabetes had witnessed progressive development and success since the first case of pancreatic transplantation. Although this was a great step, wide clinical application was limited by several factors. Bariatric surgery such as gastric bypass is emerging as a promising option in obese pati... | Roux-en-Y gastric bypass is a promising option for lifelong treatment of type 2 diabetes. It has the potential to improve or cure a selected spectrum of type 1 diabetes when performed early in the disease. Further animal model studies or randomized controlled trials are needed to support our conclusion. | yes |
18670651 | Do the changes in the serum levels of IL-2, IL-4, TNFalpha, and IL-6 reflect the inflammatory activity in the patients with post-ERCP pancreatitis? | [
"Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography (ERCP) procedure and there are some reports showing cytokine changes in ERCP-induced pancreatits.GOALS: To investigate the association between early changes (within 24 hours) in the serum interleukin (IL)-2, IL-4, tumor ... | The enhancement of serum TNFalpha and IL-6 levels in the patients with ERCP-induced pancreatitis reflects the inflammatory activity. Additionally, these cytokines together with IL-4 can be used in clinical laboratory monitoring of ERCP. | yes |
11034241 | Is routine intraoperative frozen-section examination of sentinel lymph nodes in breast cancer worthwhile? | [
"Routine intraoperative frozen section (FS) of sentinel lymph nodes (SLN) can detect metastatic disease, allowing immediate axillary dissection and avoiding the need for reoperation. Routine FS is also costly, increases operative time, and is subject to false-negative results. We examined the benefit of routine int... | In breast cancer patients having SLN biopsy, the failure of routine intraoperative FS is largely the failure to detect micrometastatic disease. The benefit of routine intraoperative FS increases with tumor size. Routine FS may not be indicated in patients with the smallest invasive cancers. | maybe |
23240452 | Can we predict urinary stone composition based on an analysis of microelement concentration in the hair and urine? | [
"In recent years the role of trace elements in lithogenesis has received steadily increasing attention.",
"This study was aimed to attempt to find the correlations between the chemical content of the stones and the concentration of chosen elements in the urine and hair of stone formers.",
"The proposal for the ... | The data obtained did not allow for the creation of a proper and practical algorithm to predict stone chemical composition based on hair and urine analysis. | no |
21979183 | Does intra-abdominal desmoid disease affect patients with an ileal pouch differently than those with an ileorectal anastomosis? | [
"Nobody has analyzed the sequelae of desmoids according to the type of surgery that precipitated them.",
"This study aims to determine whether the clinical effects of abdominal desmoids would be worse in patients with restorative proctocolectomy than in patients with ileorectal anastomosis.",
"This is a retrosp... | The morbidity associated with desmoid tumors has not been shown to differ, whether they arise after restorative proctocolectomy or ileorectal anastomosis. | no |
12607120 | Does anastomotic leakage affect functional outcome after rectal resection for cancer? | [
"Anastomotic leakage is the most threatening early complication in sphincter-preserving rectal cancer surgery. While the oncological consequences have been well examined, only few data exist about the functional outcome.",
"We investigated continence function in 150 patients after curative sphincter-preserving re... | Continence function remained undisturbed after anastomotic leakage due to rectal resection | no |
21914194 | Health care for immigrants in Europe: is there still consensus among country experts about principles of good practice? | [
"European Member States are facing a challenge to provide accessible and effective health care services for immigrants. It remains unclear how best to achieve this and what characterises good practice in increasingly multicultural societies across Europe. This study assessed the views and values of professionals wo... | Experts across Europe asserted the right to culturally sensitive health care for all immigrants. There is a broad consensus among experts about the major principles of good practice that need to be implemented across Europe. However, there also is some disagreement both within and between countries on specific issues t... | maybe |
11334578 | Is there awareness of pharmaceutical expenditure in the reformed primary care system? | [
"To evaluate the effectiveness of feeding information on pharmacy back to primary care doctors in order to create awareness (knowledge) of pharmaceutical expenditure (PE).",
"Retrospective cross-sectional study, through personal interview.",
"Reformed PC, Sabadell, Barcelona.",
"The 80 PC doctors working with... | In view of the results, it is concluded that there is no awareness of PE among the doctors in the reformed PC in our area. This poses a question over the efficacy of feed-back of pharmacy information in order to create this awareness. This information needs to be more frequent and richer in content, and to be complemen... | no |
21593045 | Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? | [
"Women with ovaries of polycystic morphology (PCO), without any other features of polycystic ovary syndrome (PCOS), respond similarly to women with PCOS when stimulated with exogenous gonadotrophins, and both groups share various endocrinological disturbances underlying their pathology. In women with PCOS, metformi... | There appears to be no benefit in metformin co-treatment before and during IVF in women with PCO without any other features of PCOS. Clinical Trials.gov: NCT01046032. | no |
16647887 | Are women who are treated for hypothyroidism at risk for pregnancy complications? | [
"The purpose of this study was to investigate the outcomes that are associated with pregnancy and treated hypothyroidism.",
"This was a retrospective cohort study of all women who received prenatal care and were delivered at the University of California, San Francisco, between 1989 and 2001. All patients with hyp... | Compared with patients without hypothyroidism, patients with treated hypothyroidism are not at any increased risk for perinatal morbidity. | no |
18439500 | Laparoscopic myomectomy: do size, number, and location of the myomas form limiting factors for laparoscopic myomectomy? | [
"To assess whether it is possible for an experienced laparoscopic surgeon to perform efficient laparoscopic myomectomy regardless of the size, number, and location of the myomas.",
"Prospective observational study (Canadian Task Force classification II-1).",
"Tertiary endoscopy center.",
"A total of 505 healt... | Laparoscopic myomectomy can be performed by experienced surgeons regardless of the size, number, or location of the myomas. | no |
22970993 | Does sex affect the outcome of laparoscopic cholecystectomy? | [
"The aim of our study was to determine the effect of sex on the outcome of laparoscopic cholecystectomy in terms of operative time, conversion to open cholecystectomy, postoperative complications and mean hospital stay.",
"In this retrospective observational study, we analyzed the medical records of 2061 patients... | Laparoscopic cholecystectomy is often challenging in men on account of more adhesions and inflammation. This leads to higher conversion rates and more postoperative complications. Optimized planning and a more experienced operating surgeon may help overcome these problems. | yes |
16498158 | Is atropine needed with ketamine sedation? | [
"To compare atropine with placebo as an adjunct to ketamine sedation in children undergoing minor painful procedures. Outcome measures included hypersalivation, side effect profile, parental/patient satisfaction, and procedural success rate.",
"Children aged between 1 and 16 years of age requiring ketamine proced... | Ketamine sedation was successful and well tolerated in all cases. The use of atropine as an adjunct for intramuscular ketamine sedation in children significantly reduces hypersalivation and may lower the incidence of post-procedural vomiting. Atropine is associated with a higher incidence of a transient rash. No seriou... | yes |
15000338 | Do family physicians know the costs of medical care? | [
"To determine the cost of 46 commonly used investigations and therapies and to assess British Columbia family doctors' awareness of these costs.",
"Mailed survey asking about costs of 23 investigations and 23 therapies relevant to family practice. A random sample of 600 doctors was asked to report their awareness... | Family doctors in British Columbia have little awareness of the costs of medical care. | no |
11247896 | Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? | [
"In familial adenomatous polyposis (FAP), correlations between site of mutation in the adenomatous polyposis coli (APC) gene and severity of colonic polyposis or extracolonic manifestations are well known. While mutation analysis is important for predictive diagnosis in persons at risk, its relevance for clinical m... | As age at manifestation and course of the disease may be rather variable, even in carriers of identical germline mutations, therapeutic decisions should be based on colonoscopic findings in individual patients rather than on the site of mutation. However, in patients with mutations within codons 1445-1580, it may be ad... | maybe |
19145527 | Do emergency medical services professionals think they should participate in disease prevention? | [
"The primary objective of the study was to determine emergency medical services (EMS) professionals' opinions regarding participation in disease and injury prevention programs. A secondary objective was to determine the proportion of EMS professionals who had participated in disease prevention programs.",
"As par... | The majority of EMS professionals thought that they should participate in disease and injury prevention programs. The respondents were mixed as to whether prevention services should be provided while on emergency calls, but those with experience providing these services were more likely to agree with providing them dur... | maybe |
21880023 | Does exercise during pregnancy prevent postnatal depression? | [
"To study whether exercise during pregnancy reduces the risk of postnatal depression.",
"Randomized controlled trial.",
"Trondheim and Stavanger University Hospitals, Norway.",
"Eight hundred and fifty-five pregnant women were randomized to intervention or control groups.",
"The intervention was a 12 week e... | We did not find a lower prevalence of high EPDS scores among women randomized to regular exercise during pregnancy compared with the control group. However, a subgroup of women in the intervention group who did not exercise regularly prior to pregnancy had a reduced risk of postnatal depression. | no |
22768311 | Is human cytomegalovirus infection associated with hypertension? | [
"Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension. We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES).",
"We analyzed data on 2979 men and 3324 women... | In this nationally representative population-based survey, HCMV seropositivity is associated with hypertension in women in the NHANES population. This association is largely explained by the association of hypertension with age and the increase in past exposure to HCMV with age. | no |
25636371 | Is it possible to stop treatment with nucleos(t)ide analogs in patients with e-antigen negative chronic hepatitis B? | [
"Treatment of HBeAg-negative chronic hepatitis B (CHB) with nucleos(t)ide analogues (NA) is usually indefinite, since the loss of HBsAg, as a criterion for its discontinuation, is a rare event. Recent evidence suggests that discontinuing NA therapy may be feasible in selected patients.",
"To analyze the rate of v... | The results suggest that NA treatment can be stopped in selected patients with CHB as long as they are not cirrhotic, have completed a minimum period of treatment, have normal ALT and sustained undetectable DNA. These patients should be closely monitored during the first year and then indefinitely. | maybe |
16968183 | Is laparoscopic cholecystectomy safe and acceptable as a day case procedure? | [
"This study reviewed the results of performing day case laparoscopic cholecystectomy to assess the feasibility and safety of the procedure as a day case.",
"This is a prospective study of 150 day case laparoscopic cholecystectomies performed between September 1999 and December 2004 under the care of the senior au... | Day case laparoscopic cholecystectomy is safe, feasible, and cost-effective when patients are carefully selected. It provides good patient satisfaction. | yes |
25735444 | Rectal cancer threatening or affecting the prostatic plane: is partial prostatectomy oncologically adequate? | [
"A multicentre, retrospective study was conducted of patients with rectal cancer threatening or affecting the prostatic plane, but not the bladder, judged by magnetic resonance imaging (MRI). The use of preoperative chemoradiotherapy and the type of urologic resection were correlated with the status of the patholog... | Preoperative chemoradiation is mandatory in male patients with a threatened or affected anterior circumferential margin on preoperative MRI. In patients with preoperative prostatic infiltration, prostatic resection is necessary. In this group of patients partial prostatectomy seems to be oncologically safe. | maybe |
22303473 | Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients? | [
"Family caregivers of dementia patients are at increased risk of developing depression or anxiety. A multi-component program designed to mobilize support of family networks demonstrated effectiveness in decreasing depressive symptoms in caregivers. However, the impact of an intervention consisting solely of family ... | This study did not demonstrate preventive effects of family meetings on the mental health of family caregivers. Further research should determine whether this intervention might be more beneficial if provided in a more concentrated dose, when applied for therapeutic purposes or targeted towards subgroups of caregivers. | no |
21276532 | Does preoperative anemia adversely affect colon and rectal surgery outcomes? | [
"Complications associated with blood transfusions have resulted in widespread acceptance of low hematocrit levels in surgical patients. However, preoperative anemia seems to be a risk factor for adverse postoperative outcomes in certain surgical patients. This study investigated the National Surgical Quality Improv... | This large multicenter database analysis suggests that the presence of severe and moderate and even mild preoperative anemia is an independent risk factor for complications and a longer hospital stay after colon surgery. | yes |
25891436 | Is serum total bilirubin useful to differentiate cardioembolic stroke from other stroke subtypes? | [
"Previous studies have reported that the total bilirubin (TB) level is associated with coronary artery disease, heart failure and atrial fibrillation. These heart diseases can produce cardiogenic cerebral embolism and cause cardioembolic stroke. However, whether the serum TB could be a biomarker to differentiate ca... | Serum TB level was independently associated with cardioembolic stroke. The combination of clinical data and serum TB may be a feasible strategy to diagnose cardioembolic stroke in the acute phase. | yes |
24450673 | Delayed imaging in routine CT examinations of the abdomen and pelvis: is it worth the additional cost of radiation and time? | [
"The purpose of this study was to retrospectively assess the potential benefits of delayed phase imaging series in routine CT scans of the abdomen and pelvis.",
"Routine contrast-enhanced abdominopelvic CT scans of 1000 consecutively examined patients (912 men, 88 women; average age, 60 years; range, 22-94 years)... | An additional delayed phase through the abdomen in routine contrast-enhanced CT examinations of the abdomen and pelvis is of low yield, particularly if reliable follow-up imaging to further elucidate uncertain findings is available. | no |
17914515 | Suturing of the nasal septum after septoplasty, is it an effective alternative to nasal packing? | [
"To discuss and compare the results of suturing the nasal septum after septoplasty with the results of nasal packing.",
"A prospective study, which was performed at Prince Hashem Military Hospital in Zarqa, Jordan and Prince Rashed Military Hospital in Irbid, Jordan between September 2005 and August 2006 included... | Septal suturing after septoplasty offers the following advantages: elimination of discomfort for the patients, minimal complications, the outcome is almost the same as with nasal packing, and finally the hospital stay is less than with nasal packing. Therefore, suturing of the nasal septum after septoplasty should be a... | yes |
19444061 | Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury? | [
"Retrospective outcome measurement study.",
"The purpose of this study is to assess whether ossification of the posterior longitudinal ligament (OPLL) affects neurologic outcomes in patients with acute cervical spinal cord injury (SCI).",
"There have so far been few reports examining the relationship between OP... | No evidence was found for OPLL to have any effect on the initial neurologic status or recovery in motor function after traumatic cervical cord injury, suggesting that the neurologic outcome is not significantly dependent on canal space. | no |
21592383 | Canada's Compassionate Care Benefit: is it an adequate public health response to addressing the issue of caregiver burden in end-of-life care? | [
"An increasingly significant public health issue in Canada, and elsewhere throughout the developed world, pertains to the provision of adequate palliative/end-of-life (P/EOL) care. Informal caregivers who take on the responsibility of providing P/EOL care often experience negative physical, mental, emotional, socia... | This study, from the perspective of family caregivers, demonstrates that the CCB is not living up to its full potential in sustaining informal P/EOL caregivers. Effort is required to transform the CCB so that it may fulfill the potential it holds for serving as one public health response to caregiver burden that forms ... | no |
11053064 | Fatigue in primary Sjögren's syndrome: is there a link with the fibromyalgia syndrome? | [
"To determine whether fibromyalgia (FM) is more common in patients with primary Sjögren's syndrome (pSS) who complain of fatigue. The association and prevalence of fatigue and FM was recorded in a group of patients with pSS and a control group of lupus patients, a subset of whom had secondary Sjögren's syndrome (sS... | The results show that fatigue in patients with pSS and sSS is not due to the coexistence of FM in most cases. A lower incidence in the United Kingdom of FM in patients with pSS was found than has been previously reported. | no |
9745063 | Is laparoscopic sonography a reliable and sensitive procedure for staging colorectal cancer? | [
"Laparoscopic colectomy has developed rapidly with the explosion of technology. In most cases, laparoscopic resection is performed for colorectal cancer. Intraoperative staging during laparoscopic procedure is limited. Laparoscopic ultrasonography (LUS) represents the only real alternative to manual palpation durin... | The results obtained in this study demonstrate that LUS is an accurate and highly sensitive procedure in staging colorectal cancer, providing a useful and reliable diagnostic tool complementary to laparoscopy. | yes |
15475728 | Alcohol consumption and acute myocardial infarction: a benefit of alcohol consumed with meals? | [
"The apparent favorable effect of alcohol on the risk of acute myocardial infarction (MI) may be related to its hypoinsulinemic effect when consumed with meals. We studied how the timing of alcohol consumption in relation to meals might affect the risk of MI in a population with relatively high regular alcohol cons... | Alcohol drinking during meals was inversely related with risk of acute MI, whereas alcohol drinking outside meals only was unrelated to risk. | yes |
28011794 | Can Ambu self-inflating bag and Neopuff infant resuscitator provide adequate and safe manual inflations for infants up to 10 kg weight? | [
"Manual resuscitation devices for infants and newborns must be able to provide adequate ventilation in a safe and consistent manner across a wide range of patient sizes (0.5-10 kg) and differing clinical states. There are little comparative data assessing biomechanical performance of common infant manual resuscitat... | The Ambu SIB was able to accurately deliver targeted pressures across all three models from preterm to infant. The Neopuff infant resuscitator was unable to deliver the targeted pressures in the infant model developing clinically significant levels of inadvertent PEEP which may pose risk during infant resuscitation. | maybe |
24098953 | Are IgM-enriched immunoglobulins an effective adjuvant in septic VLBW infants? | [
"All VLBW infants from January 2008 to December 2012 with positive blood culture beyond 72 hours of life were enrolled in a retrospective cohort study. Newborns born after June 2010 were treated with IgM-eIVIG, 250 mg/kg/day iv for three days in addition to standard antibiotic regimen and compared to an historical ... | This hypothesis-generator study shows that IgM-eIVIG is an effective adjuvant therapy in VLBW infants with proven sepsis. Randomized controlled trials are warranted to confirm this pilot observation. | yes |
24827404 | Is resected stomach volume related to weight loss after laparoscopic sleeve gastrectomy? | [
"Laparoscopic sleeve gastrectomy (LSG) was initially performed as the first stage of biliopancreatic diversion with duodenal switch for the treatment of super-obese or high-risk obese patients but is now most commonly performed as a standalone operation. The aim of this prospective study was to investigate outcomes... | Mean %EBWL after LSG was not significantly different among three groups of patients divided according to resected stomach volume. Resected stomach volume was significantly greater in patients with higher preoperative body mass index. | no |
28407529 | Resection of colorectal liver metastases after second-line chemotherapy: is it worthwhile? | [
"Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line.",
"From January 2005 to June 2013, 5624 and... | CLM resection following second-line PCT, after oncosurgically favourable selection, could bring similar OS compared to what observed after first-line. For initially unresectable patients, OS or DFS is comparable between first- and second-line PCT. Surgery should not be denied after the failure of first-line chemotherap... | no |
27928673 | Do ART patients face higher C-section rates during their stage of delivery? | [
"The mode of delivery depends on multiple parameters. After assisted reproductive technology (ART), previous studies have shown elevated C-section rates but few studies differentiated between elective and emergency operations and different protocols of cryopreservation. Because these studies did not use multiparity... | Patients after ART treatment suffer from higher C-section rates during their stage of delivery. | yes |
20842006 | Neck pain treatment with acupuncture: does the number of needles matter? | [
"Acupuncture has been successfully used in myofascial pain syndromes. However, the number of needles used, that is, the dose of acupuncture stimulation, to obtain the best antinociceptive efficacy is still a matter of debate. The question was addressed comparing the clinical efficacy of two different therapeutic sc... | For this pathology, the number of needles, 5 or 11, seems not to be an important variable in determining the therapeutic effect when the time of stimulation is the same in the two groups. | no |
9140335 | Does fluoridation reduce the use of dental services among adults? | [
"The authors determine whether prevention influences the use of health services. Fluoridation's effect on restorative dental demand among 972 Washington state employees and spouses, aged 20 to 34 years, in two fluoridated communities and a nonfluoridated community was examined.",
"At baseline, adults were intervi... | Among adults aged 20 to 34 years with private dental insurance, fluoridation reduces oral disease but may or may not reduce use of restorative services, depending on dentists' clinical decisions. | maybe |
12142826 | Pertrochanteric fractures: is there an advantage to an intramedullary nail? | [
"To compare the results between a sliding compression hip screw and an intramedullary nail in the treatment of pertrochanteric fractures.",
"Prospective computer-generated randomization of 206 patients into two study groups: those treated by sliding compression hip screw (Group 1; n = 106) and those treated by in... | There is no advantage to an intramedullary nail versus a sliding compression hip screw for low-energy pertrochanteric fractures AO/OTA 31-A1 and A2, specifically with its increased cost and lack of evidence to show decreased complications or improved patient outcome. | no |
17329379 | Are the GFRUP's recommendations for withholding or withdrawing treatments in critically ill children applicable? | [
"To evaluate feasibility of the guidelines of the Groupe Francophone de Réanimation et Urgence Pédiatriques (French-speaking group of paediatric intensive and emergency care; GFRUP) for limitation of treatments in the paediatric intensive care unit (PICU).",
"A 2-year prospective survey.",
"A 12-bed PICU at the... | GFRUPs procedure was applicable in most cases. The main difficulties were anticipating the correct date for the meeting and involving nurses in the procedure. Children for whom the procedure was interrupted because of clinical improvement and who survived in poor condition without a formal decision pointed out the need... | yes |
27288618 | Is inhaled prophylactic heparin useful for prevention and Management of Pneumonia in ventilated ICU patients? | [
"To determine whether prophylactic inhaled heparin is effective for the prevention and treatment of pneumonia patients receiving mechanical ventilation (MV) in the intensive care unit.",
"A phase 2, double blind randomized controlled trial stratified for study center and patient type (non-operative, post-operativ... | Nebulized heparin cannot be recommended for prophylaxis against VAP or to hasten recovery from pneumonia in patients receiving MV. | no |
21873082 | Is the h-index predictive of greater NIH funding success among academic radiologists? | [
"Despite rapid adoption of the Hirsch index (h-index) as a measure of academic success, the correlations between the h-index and other metrics of productivity remain poorly understood. The aims of this study were to determine whether h-indices were associated with greater National Institutes of Health (NIH) funding... | Having obtained at least one NIH grant was associated with a higher h-index, yet multiple or large grants, such as those for program projects, were not predictive of higher h-indices. | yes |
21739621 | Does obesity predict knee pain over fourteen years in women, independently of radiographic changes? | [
"To examine longitudinal patterns in body mass index (BMI) over 14 years and its association with knee pain in the Chingford Study.",
"We studied a total of 594 women with BMI data from clinic visits at years (Y) 1, 5, 10, and 15. Knee pain at Y15 was assessed by questionnaire. Associations between BMI over 14 ye... | Over 14 years, a higher BMI predicts knee pain at Y15 in women, independently of radiographic knee OA. When adjusted, the association was significant in bilateral, not unilateral, knee pain, suggesting alternative pathologic mechanisms may exist. The longitudinal effect of BMI on knee pain at Y15 is equally important a... | yes |
20073599 | Do liquid-based preparations of urinary cytology perform differently than classically prepared cases? | [
"The cytomorphology of liquid-based preparations in urine cytology is different than classic slide preparations.",
"To compare the performance of liquid-based preparation specimens to classically prepared urine specimens with a malignant diagnosis in the College of American Pathologists Interlaboratory Comparison... | Liquid-based preparations performed significantly better in urinary cytology challenges when evaluating malignant categories in the College of American Pathologists interlaboratory comparison program. The liquid-based preparation challenges also performed better for the exact reference interpretation of HGUCA, but no d... | yes |
16216859 | Does a well developed collateral circulation predispose to restenosis after percutaneous coronary intervention? | [
"To evaluate whether a well developed collateral circulation predisposes to restenosis after percutaneous coronary intervention (PCI).",
"Prospective observational study.",
"58 patients undergoing elective single vessel PCI in a tertiary referral interventional cardiac unit in the UK.",
"Collateral flow index... | A well developed collateral circulation does not predict an increased risk of restenosis after PCI. | no |
22521460 | Does route of delivery affect maternal and perinatal outcome in women with eclampsia? | [
"The route of delivery in eclampsia is controversial. We hypothesized that adverse maternal and perinatal outcomes may not be improved by early cesarean delivery.",
"This was a randomized controlled exploratory trial carried out in a rural teaching institution. In all, 200 eclampsia cases, carrying ≥34 weeks, wer... | A policy of early cesarean delivery in eclampsia, carrying ≥34 weeks, is not associated with better outcomes. | no |
23972333 | Has the prevalence of health care services use increased over the last decade (2001-2009) in elderly people? | [
"(1) To describe the prevalence of general practitioner visits and hospitalization according to sex and age groups; (2) to identify which factors are independently associated with a higher use of health care services among elderly Spanish; and (3) to study the time trends in the prevalence of use of health care ser... | The current study revealed an increase in health care services utilization from 2001 to 2009 in the older Spanish population. | yes |
23719685 | Does high-dose radiotherapy benefit palliative lung cancer patients? | [
"The present analysis compares two palliative treatment concepts for lung cancer in terms of overall survival.",
"Survival data from 207 patients were used in a retrospective analysis. All patients received palliative treatment comprising either 25 Gy applied in 5 fractions or 50 Gy in 20 fractions. A subgroup an... | The palliative treatment concept of 25 Gy applied in 5 fractions is sufficient for radiation of lung cancer, given that there was no obvious survival improvement in patients treated with the higher total dose regimen. | no |
11601252 | Is endothelin-1 an aggravating factor in the development of acute pancreatitis? | [
"We have reported previously that cerulein-induced edematous pancreatitis would transform into hemorrhagic pancreatitis by administration of endothelin-1 in rats. In the present study, we tried to protect rat model from developing into hemorrhagic pancreatitis with BQ123 (an ETA receptor antagonist).",
"The rat m... | These results suggest that endothelin-1 should play a role in aggravating the development of acute hemorrhagic pancreatitis, through its action on the pancreatic microcirculation. | yes |
23506394 | Malnutrition, a new inducer for arterial calcification in hemodialysis patients? | [
"Arterial calcification is a significant cardiovascular risk factor in hemodialysis patients. A series of factors are involved in the process of arterial calcification; however, the relationship between malnutrition and arterial calcification is still unclear.",
"68 hemodialysis patients were enrolled in this stu... | Malnutrition is prevalent in hemodialysis patients and is associated with arterial calcification and the expressions of BMP2 and MGP in calcified radial arteries. Malnutrition may be a new inducer candidate for arterial calcification in hemodialysis patients. | yes |
19575307 | Does glomerular hyperfiltration in pregnancy damage the kidney in women with more parities? | [
"We aimed to investigate the glomerular hyperfiltration due to pregnancy in women with more parities.",
"Five hundred women aged 52.57 +/- 8.08 years, without a history of hypertension, diabetes mellitus or complicated pregnancy were involved in the study. They were divided into three groups. Group 1: women with ... | In our study, we suggest that glomerular hyperfiltration due to pregnancy does not have adverse effects on kidney in women with more parities. Pregnancy may have possible protective mechanisms for kidney against adverse effects of glomerular hyperfiltration. | no |
12626177 | Can the Internet be used to improve sexual health awareness in web-wise young people? | [
"To assess Internet use amongst young people to determine whether it would be a practical way to provide sex education and information.",
"Year 10 students (aged 14-15 years) from North Nottinghamshire schools were asked to participate in focus groups to discuss the Internet. A series of predefined questions were... | The Internet would be a practical and accessible way of delivering sexual health education to young people, particularly if it is incorporated into activities and websites they enjoy. | maybe |
15483019 | Is eligibility for a chemotherapy protocol a good prognostic factor for invasive bladder cancer after radical cystectomy? | [
"To assess whether eligibility to an adjuvant chemotherapy protocol in itself represents a good prognostic factor after radical cystectomy for bladder cancer.",
"Between April 1984 and May 1989, our institution entered 35 patients with invasive bladder cancer into the Swiss Group for Clinical and Epidemiological ... | These data suggest that being willing and fit enough for a chemotherapy protocol is a good prognostic factor for invasive bladder cancer. This eligibility bias emphasizes the need for prospective, randomized trials, and indicates that single-group studies using historical or matched controls have to be interpreted with... | yes |
24783217 | Can ki-67 play a role in prediction of breast cancer patients' response to neoadjuvant chemotherapy? | [
"Currently the choice of breast cancer therapy is based on prognostic factors. The proliferation marker Ki-67 is used increasingly to determine the method of therapy. The current study analyses the predictive value of Ki-67 in foreseeing breast cancer patients' responses to neoadjuvant chemotherapy.",
"This study... | Our data shows that the Ki-67 value predicts the response to neoadjuvant chemotherapy as a function of the molecular subtype, reflecting the daily routine concerning Ki-67 and its impressing potential and limitation as a predictive marker for neoadjuvant chemotherapy response. | yes |
17916877 | Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects? | [
"To determine the therapeutic effect (alleviation of vascular type headache) and side effects of a slow intravenous metoclopramide infusion over 15 min compared with those effects of a bolus intravenous metoclopramide infusion over 2 min in the treatment of patients with recent onset vascular type headache.",
"Al... | Slowing the infusion rate of metoclopramide is an effective strategy for the improvement of headache and reducing the incidence of akathisia in patients with vascular type headache. | yes |
17244100 | Can patient coaching reduce racial/ethnic disparities in cancer pain control? | [
"Minority patients with cancer experience worse control of their pain than do their white counterparts. This disparity may, in part, reflect more miscommunication between minority patients and their physicians. Therefore, we examined whether patient coaching could reduce disparities in pain control in a secondary a... | Patient coaching offers promise as a means of reducing racial/ethnic disparities in pain control. Larger studies are needed to validate these findings and to explore possible mechanisms. | yes |
27146470 | Are tuberculosis patients adherent to prescribed treatments in China? | [
"Tuberculosis (TB) patients face numerous difficulties adhering to the long-term, rigorous TB treatment regimen. Findings on TB patients' treatment adherence vary across existing literature and official reports. The present study attempted to determine the actual treatment adherence of new TB patients and to identi... | Despite recent efforts, a large proportion of newly confirmed TB patients could not adhere to standard TB treatment, and patients' lost to follow-up was still a serious problem. Poor treatment supervision and heavy financial burden might be the main causes for non-adherence. More needs to be done to enhance treatment s... | maybe |
16564683 | Is there any interest to perform ultrasonography in boys with undescended testis? | [
"To evaluate the accuracy of ultrasonographic examination in boys with an undescended testis.",
"All patients who were referred to the paediatric surgeon after detection of an undescended testis were evaluated prospectively between November 2001 and November 2004. Among these 377 patients, 87 were referred with a... | Sonography has no place in the diagnosis of undescended testis. | no |
23147106 | Is peak concentration needed in therapeutic drug monitoring of vancomycin? | [
"We analyzed the pharmacokinetic-pharmacodynamic relationship of vancomycin to determine the drug exposure parameters that correlate with the efficacy and nephrotoxicity of vancomycin in patients with methicillin-resistant Staphylococcus aureus pneumonia and evaluated the need to use peak concentration in therapeut... | These results suggest little need to use peak concentration in vancomycin TDM because Cmin/MIC and Cmin are sufficient to predict the efficacy and safety of vancomycin. | no |
21550158 | Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? | [
"This investigation assesses the effect of platelet-rich plasma (PRP) gel on postoperative pain, swelling, and trismus as well as healing and bone regeneration potential on mandibular third molar extraction sockets.",
"A prospective randomized comparative clinical study was undertaken over a 2-year period. Patien... | The PRP group recorded reduced pain, swelling, and trismus as well as enhanced and faster bone healing compared with those in the control. Hence the study showed that topical application of PRP gel has a beneficial effect in enhancing socket healing after third molar surgery. | yes |
17559449 | Are sugars-free medicines more erosive than sugars-containing medicines? | [
"The reduced use of sugars-containing (SC) liquid medicines has increased the use of other dose forms, potentially resulting in more widespread dental effects, including tooth wear. The aim of this study was to assess the erosive potential of 97 paediatric medicines in vitro.",
"The study took the form of in vitr... | Paediatric SF medicines were not more erosive than SC medicines in vitro; a more significant predictor of their erosive potential was dose form. | no |
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