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# Liver Cell Biology Research Group(LIVR) |
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Brussels Health Campus • Vrije Universiteit Brussel • Brussels • Belgium |
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## Mission |
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Advance understanding of liver cell diversity, regeneration and fibrosis to drive novel biomarkers, in vitro disease models and therapeutic strategies for chronic liver disorders. |
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## Research Objectives |
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- **Cellular Characterization** |
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Profile healthy vs. diseased liver cell types at single‑cell resolution. |
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- **Fibrosis Mechanisms** |
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Dissect pathways of hepatic stellate cell activation, fibrogenesis and resolution. |
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- **Biomarker Discovery** |
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Identify stellate‑cell‑specific markers for non‑invasive fibrosis staging. |
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- **Disease Modeling** |
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Build iPSC‑derived liver cell co‑cultures and organoids to recreate MASLD and other chronic conditions. |
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- **Regeneration & Progenitors** |
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Elucidate the role of liver progenitor cells in tissue repair. |
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## Key Collaborations & Networks |
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- **ImAgE‑D** (Marie Skłodowska‑Curie ITN, Oct 2023 – Sep 2027) |
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High‑speed, super‑resolution imaging of endothelial and liver cells. |
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- **DeLIVERy** (EIC Pathfinder, May 2022 – Apr 2026) |
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Personalized polypharmacy testing on patient‑derived mini‑livers. |
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## Publications & Resources |
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- **Latest Publications** |
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- *JHEP Reports*: “HSC single‑cell atlas reveals activation across etiologies” |
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- *Biofabrication*: “iPSC‑derived liver spheroids to model fibrosis” |
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- *Science*: “Hippo signaling instructs ectopic organ growth” |
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- **Full Publication List:** |
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Browse all [publications (2010–present)](https://pubmed.ncbi.nlm.nih.gov/?term=van+Grunsven+L&sort=date) |
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Research Portal [Click here](https://researchportal.vub.be/en/organisations/liver-cell-biology/publications/). |
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## Team & Training |
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- **Current Members** | **Former Members** |
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Explore profiles and roles on our [Team page](https://livr.research.vub.be/livr-members/livr-members). |
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- **Doctoral & Post‑doc Training** |
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Interactive workshops, imaging courses, and 3R‑principle seminars for early‑career researchers. |
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## News & Events |
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- **Belgian Stem Cell Meeting** – Nov 28 2025 @ ULB Erasme Campus |
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- **Upcoming Seminars** & “Film Nights” showcasing 3R approaches and mini‑liver therapies |
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- Follow live updates in [News & Events](https://livr.research.vub.be/news-events). |
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## Contact |
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Laarbeeklaan 103, Building D – Room D022 |
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1090 Brussels, Belgium |
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jmlazou@vub.be | +32 2 477 4409 |
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> _“By unlocking liver cell biology, we pave the way for precision therapies in chronic liver disease.”_ |
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