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values | query stringlengths 26 249 | positive stringlengths 20 1.8k | negatives listlengths 4 4 | query_id stringlengths 1 4 | positive_id stringlengths 4 9 | negative_ids listlengths 4 4 | task_type stringclasses 2
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|---|---|---|---|---|---|---|---|---|---|
efef6341e788e4ee427af9ee65d05614 | mteb/scifact | A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake. | Prevention of malaria in long-term travelers.. CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria prevention primarily address prevention of Plasmodium falciparum infections in short-term... | [
"Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir. BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with an... | 26 | 32390525 | [
"14260013",
"9745001",
"4910408",
"35301079"
] | scientific_claim_retrieval | scientific |
76bdac02096932685414c5a2cb792aae | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Multiplex Evaluation of Influenza Neutralizing Antibodies with Potential Applicability to In-Field Serological Studies. The increased number of outbreaks of H5 and H7 LPAI and HPAI viruses in poultry has major public and animal health implications. The continuous rapid evolution of these subtypes and the emergence of n... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | a9f6hh7t | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
f6928c68b43a63620f5a362e79527d3e | mteb/scifact | Glycan adaptation involves insertion-deletion events. | Broad neutralization coverage of HIV by multiple highly potent antibodies. Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus (HIV)... | [
"Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression. The brain interprets experiences and translates them into behavioral and physiological responses. Stressful events are those which are threatening or, at the very... | 473 | 4373433 | [
"6123521",
"22312627",
"25462689",
"35861290"
] | scientific_claim_retrieval | scientific |
15b7c479c84ff8b82cb3b989c93a951f | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011–June 2015. Given the rapid rate of global spread and consequently healthcare costs related to influenza, surveillance plays an important role in monitoring the emerging pand... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | b8t4a57r | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
88e8dd968917fdd4d192b935285bd346 | mteb/scifact | The number of unfertilized oocytes in mated hermaphrodites increases with age. | TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance. Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis elegans ceases in mid-adulthood. Although somatic aging has been studied in both worms and... | [
"Decrease of learning capacity in offspring with increasing paternal age in the rat.. The same 15 male Wistar rats at the ages of 2.5, 6, 10, 14, 18, and 22 months were successively randomly mated with 2.5-month-old females. In a separate experiment, 15 male Wistar rats at the age of 2.5 months and 15 at the age of... | 1244 | 18949516 | [
"36178047",
"28598374",
"14021596",
"7808055"
] | scientific_claim_retrieval | scientific |
86ac1b74095264430dc03bd98d20d413 | mteb/scifact | Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies. | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.. CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain cha... | [
"Immune reconstitution after cord blood transplantation: peculiarities, clinical implications and management strategies.. Umbilical cord blood (UCB) is now widely used as an alternative hematopoietic stem cell source for patients lacking closely matched related or unrelated adult donors. UCB transplantation has tra... | 144 | 10582939 | [
"27243019",
"35811036",
"40164383",
"2559303"
] | scientific_claim_retrieval | scientific |
c909862665740569001f98e9def4454f | mteb/scifact | Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss. | The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity. Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological feat... | [
"The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.. The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD), an early-onset neurodegenerative disorder. The RNA/... | 181 | 16966326 | [
"9217800",
"42035464",
"23403754",
"7137057"
] | scientific_claim_retrieval | scientific |
d44856b59ccaa0e98a96e4b07cabfc4a | mteb/scifact | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | Determinants of adolescent physical activity and inactivity patterns.. OBJECTIVES Despite recognition of the important influence of environmental determinants on physical activity patterns, minimal empirical research has been done to assess the impact of environmental/contextual determinants of physical activity. This ... | [
"Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children. The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether i... | 945 | 13083189 | [
"18537148",
"11201004",
"24746892",
"8595678"
] | scientific_claim_retrieval | scientific |
18467cea453b341de4eb0aff698da12d | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Balancing Expediency and Scientific Rigor in Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | g0yxf99c | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
03b8b86a2e3e327a3a0114f82b55de23 | mteb/scifact | Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes. | Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.. Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in t... | [
"Key role for IL-21 in experimental autoimmune uveitis.. IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas... | 1028 | 11899391 | [
"7115651",
"36642096",
"5476778",
"26068103"
] | scientific_claim_retrieval | scientific |
caa0e146763d15a1b8959f311bee6a64 | mteb/scifact | PrimPol degrades short DNA replication intermediates on the leading strand during DNA replication. | hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.. Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously unrecognized prim-pol in human cells, which we designate hPri... | [
"The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.. Cells cope with blockage of replication fork progression in a manner that allows DNA synthesis to be completed and genomic instability minimized. Models for resolu... | 969 | 19356271 | [
"37328025",
"36606083",
"39225849",
"25787749"
] | scientific_claim_retrieval | scientific |
8617aae6f96ca866a7c444d8ef897273 | mteb/scifact | β1/Ketel is able to bind microtubules. | P446L-importin-beta inhibits nuclear envelope assembly by sequestering nuclear envelope assembly factors to the microtubules.. The P446L mutant Drosophila importin-beta (P446L-imp-beta) has been reported to prohibit--in dominant negative fashion--nuclear envelope (NE) assembly. Along elucidating the mode of action of P... | [
"Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.. Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (... | 1407 | 29863668 | [
"21164071",
"45199834",
"2151983",
"9638032"
] | scientific_claim_retrieval | scientific |
37b985e14724c92c4f8fd14f9ddf8dd4 | mteb/trec-covid | what evidence is there for the value of hydroxychloroquine in treating Covid-19? | Considerations for Drug Interactions on QTc in Exploratory COVID-19 (Coronavirus Disease 2019) Treatment | [
"Urgent intubation without neuromuscular blocking agents and the risk of tracheostomy. Neuromuscular blocking agents play a significant role in improving the success rate for urgent intubation, although there is limited evidence about the effect on subsequent outcomes, such as the incidence of tracheostomy. In this... | 28 | 8l09j3rr | [
"f4rn9m95",
"2bau2dn8",
"d3d1n9qa",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
ce9135b3ca0b2e09a2c3da9e8a3c6b46 | mteb/scifact | Chenodeoxycholic acid treatment increases brown adipose tissue activity. | The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.. The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyro... | [
"Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse.. The genetically obese (ob/ob) mouse exhibits defective thermoregulatory responses to cold exposure. Pathophysiological explanations for this phenomenon have focused on abnormalities in intracellular metabolism or insensitivity of p... | 251 | 1568684 | [
"25687558",
"4641348",
"12280462",
"34582256"
] | scientific_claim_retrieval | scientific |
b7b45bc2ce4127dd471cb163fe3b8291 | mteb/scifact | Risk of cardiovascular events can be cut by a third by using antihypertensive drug therapy among hemodialysis patients. | Cardiovascular protection with antihypertensive drugs in dialysis patients: systematic review and meta-analysis.. Epidemiological studies demonstrate that a lower blood pressure and decline in blood pressure over months or years are associated with higher mortality in dialysis patients. In contrast, randomized, control... | [
"Chronic Hepatitis B Infection: A Review. Importance More than 240 million individuals worldwide are infected with chronic hepatitis B virus (HBV). Among individuals with chronic HBV infection who are untreated, 15% to 40% progress to cirrhosis, which may lead to liver failure and liver cancer. Observations Pegylat... | 1054 | 10072941 | [
"21700295",
"409280",
"40790033",
"21048969"
] | scientific_claim_retrieval | scientific |
5bb3d6b95ff7f0ee65cc317a15316658 | mteb/scifact | Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24. | Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). BACKGROUND Population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes for ... | [
"Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.. IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing. OBJECTIVE To evaluate the clinical effe... | 256 | 5850219 | [
"44048701",
"829646",
"25121903",
"12009265"
] | scientific_claim_retrieval | scientific |
a021d3e1f0777550e34f2fe0d1e3adb7 | mteb/scifact | RAD52 is involved in break-induced DNA replication (BIR). | Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism. Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this frag... | [
"Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlle... | 1003 | 4899981 | [
"15248287",
"6144969",
"34198365",
"7468449"
] | scientific_claim_retrieval | scientific |
34d302f444a34e1ee99c3b2b64a8524f | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | 4hcs0z65 | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
d29292d5c446b03f723f2ab38679c1bf | mteb/scifact | Increased flux of microbial products provokes immune responses. | Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.. Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colit... | [
"TLR-activated B cells suppress T cell-mediated autoimmunity.. TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is u... | 609 | 40096222 | [
"14644164",
"29023309",
"4664540",
"8692744"
] | scientific_claim_retrieval | scientific |
8052b7d4b5ce86c7c8e4ec27d6cd2a66 | mteb/scifact | MafA ubiquitination increases the recruitment of coavtivator P/CAF by MafA. | GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-trans... | [
"Effects of Abciximab on the architecture of platelet-rich clots in patients with acute myocardial infarction undergoing primary coronary intervention.. BACKGROUND Abciximab plus aspirin improves the TIMI 3 flow rate of the infarct-related artery in patients treated with either percutaneous coronary intervention or... | 748 | 11291348 | [
"17897801",
"25817686",
"11459139",
"7098463"
] | scientific_claim_retrieval | scientific |
14c5b06666825c256c84d1ed3791bf01 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene in Kawasaki Disease. Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationshi... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | wup6tig0 | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
7d4f0487e2870604649dc3c91bfee392 | mteb/scifact | Overexpressing Cnp1 N-tail variants rescues the temperature-sensitive growth defect of scm3-139. | Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin. The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. F... | [
"Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing.. Circadian disruption accelerates cancer progression, whereas circadian reinforcement could halt it. Mice with P03 pancreatic adenocarcinoma (n = 77) were synchronized and fed ad libitum (AL) or with meal timing (MT) from Ze... | 897 | 14338915 | [
"14471161",
"26117607",
"16686383",
"7717468"
] | scientific_claim_retrieval | scientific |
143300ac0c0e21b2ca035d59ea37f3e1 | mteb/scifact | At least 85% of patients exposed to radiation have activated markers of myofibroblasts. | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for c... | [
"2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes. To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and disseminatio... | 139 | 22080671 | [
"52176296",
"16737210",
"36642096",
"22547508"
] | scientific_claim_retrieval | scientific |
7f648b529006c48a7cd772c70749bf3b | mteb/scifact | Pioglitazone use is not associated with an increased risk of prostate cancer. | Pioglitazone Use and Risk of Bladder Cancer and Other Common Cancers in Persons With Diabetes.. IMPORTANCE Studies suggest pioglitazone use may increase risk of cancers. OBJECTIVE To examine whether pioglitazone use for diabetes is associated with risk of bladder and 10 additional cancers. DESIGN, SETTING, AND PARTICIP... | [
"Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis.. BACKGROUND Individuals with severely impaired lung function have an increased risk of lung cancer. Whether milder reductions in forced expiratory volume in 1 second (FEV(1)) also... | 952 | 3355397 | [
"12145359",
"20240998",
"4959368",
"6309659"
] | scientific_claim_retrieval | scientific |
9cc1ad761d13d899d79468dcf5ad76a5 | mteb/scifact | The origin of the CRF01_1b2k protein occurred between 1923 and 1956. | The Global Spread of Hepatitis C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis. BACKGROUND Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previou... | [
"Ancient Hybridization and an Irish Origin for the Modern Polar Bear Matriline. BACKGROUND Polar bears (Ursus maritimus) are among those species most susceptible to the rapidly changing arctic climate, and their survival is of global concern. Despite this, little is known about polar bear species history. Future co... | 1247 | 5114282 | [
"13277118",
"25747721",
"14191255",
"9272598"
] | scientific_claim_retrieval | scientific |
ec8f3175a6cc8d49a3da85f19a6f9ee0 | mteb/scifact | Repressing IL-18 has negative effects on atherosclerotic lesion composition and progression. | Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability.. BACKGROUND Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown. METHODS AND RESULTS In the present study, we exa... | [
"Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.. Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed \"stromal cells\") that can promote... | 1042 | 17421851 | [
"15727984",
"25263810",
"6540064",
"67787658"
] | scientific_claim_retrieval | scientific |
1a0e7570f5344754ba418cf2c5bc6cd4 | mteb/scifact | Replacement of OCT4 and SOX2 genes with GATA3 is not capable of reprogramming human cells. | Reprogramming of human fibroblasts to pluripotency with lineage specifiers.. Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process.... | [
"Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc), henceforth 4F. This process occurs independently of... | 1038 | 16287725 | [
"31882215",
"8290760",
"1630949",
"18998807"
] | scientific_claim_retrieval | scientific |
211b51cf2e900392af4efee27776c3be | mteb/scifact | Birth-weight is negatively associated with breast cancer. | Role of birthweight in the etiology of breast cancer.. Breast cancer may originate in utero. We reviewed the available evidence on the association between birthweight and the risk of breast cancer. To date, 26 research papers addressing this issue have been published. The majority of studies identified a positive link ... | [
"Birth weight and mammographic density among postmenopausal women in Sweden.. Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association of birth size measurements with mammographic density, ... | 178 | 27123743 | [
"5487448",
"16701509",
"13765757",
"25973484"
] | scientific_claim_retrieval | scientific |
3b912776aeb93b0fe63232156ad3cda6 | mteb/scifact | Antimicrobial agents are less effective due to the pressure of antimicrobial usage. | Resistance to antimicrobials in humans and animals.. Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s various reports had signalled the... | [
"Cationic host defense (antimicrobial) peptides.. Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing in organisms from insects to plants to mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fun... | 121 | 31460499 | [
"24157077",
"6407356",
"17438862",
"36497180"
] | scientific_claim_retrieval | scientific |
46dde377b9bd5da69f513708eb5bc25a | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Plasma and tissue angiotensin‐converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease. BACKGROUND: Angiotensin‐converting enzyme 2 (ACE2) is a homologue of angiotensin‐converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1‐9 a... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | 6ek80l79 | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
af42d9c332b183cf4ae55ecfb5dd4293 | mteb/scifact | Sildenafil worsens erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. | Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.. CONTEXT Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. OBJECTIVE To assess the efficacy of sildenafil citrate in men with sexual dysfunction as... | [
"Duration of androgen suppression in the treatment of prostate cancer.. BACKGROUND The combination of radiotherapy plus long-term medical suppression of androgens (> or = 2 years) improves overall survival in patients with locally advanced prostate cancer. We compared the use of radiotherapy plus short-term androge... | 1087 | 39281140 | [
"308862",
"3981244",
"30981192",
"72933407"
] | scientific_claim_retrieval | scientific |
c452efd8e342b4c85bad2eacfd903c5d | mteb/scifact | Active Ly49Q induces neutrophil polarization. | The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.. Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swift pol... | [
"Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact inhibited in their growth and respond poorly ... | 76 | 5531479 | [
"2593298",
"46517055",
"14145440",
"52925737"
] | scientific_claim_retrieval | scientific |
014ab55d3a58131afaf604afadb3f165 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Mechanisms of Hypersensitivity. Allergic reactions to drugs are not always the result of the drug’s protein-binding capacity, biotransformation, or degradation. Mediator release may occur via cross-linking of cell-bound IgE by di-(multi-) valent free drug. Physiological and pharmacological effects of histamine are medi... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 1k49tbga | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
cd61246c92ecdc3737b2202d454e9a12 | mteb/scifact | 50% of patients exposed to radiation have activated markers of mesenchymal stem cells. | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for c... | [
"CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. O... | 15 | 22080671 | [
"3531388",
"16853734",
"6280907",
"10582939"
] | scientific_claim_retrieval | scientific |
5d60f197cdcf136dfc00b66d34956434 | mteb/scifact | Removal of H3K9me3 by ectopic expression of other H3K9 demethylases improves reprogramming efficiency in SCNT experiments. | H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.. Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT ... | [
"Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.. The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation fr... | 1035 | 4547102 | [
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3d2adcc280034d0dded6f8bc9fd9b5ad | mteb/scifact | Exposure to fine particulate air pollution is unrelated to anxiety prevalence. | The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study. OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. DESIGN Observational cohort study. SETTING Nurses' Health Study.... | [
"Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.. Air pollution is a heterogeneous, complex mixture of gases, liquids, and particulate matter. Epidemiological studies have demonstrated a ... | 400 | 791050 | [
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"275294",
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] | scientific_claim_retrieval | scientific |
28c1d69913996bb6622ca3c623c86b0d | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Self-assembly into virus–like particles of the recombinant capsid protein of porcine circovirus type 3 and its application on antibodies detection. PCV3 capsid protein (Cap) is an important antigen for diagnosis and vaccine development. To achieve high-level expression of recombinant PCV3 Cap in Escherichia coli (E. co... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | 0r2g5p1i | [
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69096f02d74a6156b9349aa7a38f94ef | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Impact of Disasters and Disaster Risk Management in Singapore: A Case Study of Singapore’s Experience in Fighting the SARS Epidemic. Singapore is vulnerable to both natural and man-made disasters alongside its remarkable economic growth. One of the most significant disasters in recent history was the Severe Acute Respi... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | 86kghmzf | [
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bcdfaf84c1ad149c516089eda664de5b | mteb/scifact | ALDH1 expression is associated with poorer prognosis for breast cancer primary tumors. | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.. Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo expe... | [
"Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.. Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no rel... | 52 | 45638119 | [
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4b7de864d03e13e64c39eca193208962 | mteb/scifact | MICAL redox enzymes regulate actin dynamics. | Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse.. Semaphorin3A (Sema3A) is a repulsive guidance molecule for axons, which acts by inducing growth cone collapse through phosphorylation of CRMP2 (collapsin response mediator protein 2). Here, we show a role for CRMP2 oxidation an... | [
"Mical links semaphorins to F-actin disassembly. How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, an... | 738 | 33912020 | [
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8dc2fec86d88c9eb17c5f27c12f132b9 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Potential therapies for coronaviruses. Coronavirus replication offers several attractive targets for chemotherapy. These include: viral entry (inhibited by chloroquine and peptides); viral RNA (targeted by antisense approaches/RNAi); the main protease 3CLpro (inhibited by peptidic molecules such as HIV-1 protease inhib... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | z739ifu5 | [
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21e170fa54aaf057cb04b8fe30f414f9 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Enhancing genetic disease control by selecting for lower host infectivity and susceptibility. Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficient... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | edsn0m20 | [
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14b028ec00b51380e3e538b48902096c | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Protection of Upper Respiratory Tract, Mouth and Eyes. Pathogenic bacteria and viruses may invade via upper and lower respiratory tract and via eye mucosa. When an infected person coughs or sneezes heavily, small, invisible droplets with the infective agent may reach a good distance from the source. By using the right ... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | k4lzwfge | [
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2cf1985973f10dea4679d89d3161947b | mteb/scifact | Occipital activation levels are associated with auditory spatial performance in parietal regions of the brain. | A Functional Neuroimaging Study of Sound Localization: Visual Cortex Activity Predicts Performance in Early-Blind Individuals. Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier be... | [
"Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.. Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and diffe... | 877 | 313394 | [
"2151983",
"30351165",
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] | scientific_claim_retrieval | scientific |
ab446bd0690de8c2207bbb2894dfdd60 | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Hospital Triage System for Adult Patients Using an Influenza-Like Illness Scoring System during the 2009 Pandemic—Mexico. BACKGROUND: Pandemic influenza A (H1N1) virus emerged during 2009. To help clinicians triage adults with acute respiratory illness, a scoring system for influenza-like illness (ILI) was implemented ... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | fec4kt20 | [
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bba2c10cb65e2425de768524437a3637 | mteb/scifact | Flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules. | Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels. A prerequisite to understanding tumor pathophysiology is the ability to distinguish and monitor each compo... | [
"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neu... | 422 | 11172205 | [
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] | scientific_claim_retrieval | scientific |
2bf9e95343732c35586b9ef703f1dca9 | mteb/scifact | Sympathetic nerve activity is reduced throughout normal pregnancy. | Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women.. Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation. We te... | [
"Antioxidant Defenses in the Rat Placenta in Late Gestation: Increased Labyrinthine Expression of Superoxide Dismutases, Glutathione Peroxidase 3, and Uncoupling Protein 21. Placental oxidative stress plays a key role in the pathophysiology of placenta-related disorders, most notably preeclampsia (PE) and intrauter... | 1120 | 13907928 | [
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"39776978",
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] | scientific_claim_retrieval | scientific |
bf3018292672e999bae69c719ba220c6 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | The role of heterogeneity in contact timing and duration in network models of influenza spread in schools. Influenza poses a significant health threat to children, and schools may play a critical role in community outbreaks. Mathematical outbreak models require assumptions about contact rates and patterns among student... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | ygg093ns | [
"58czem0j",
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1d7d6a934cf1bbb075333d720ab24723 | mteb/scifact | Birth-weight is negatively associated with breast cancer. | Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.. BACKGROUND Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of materna... | [
"Birth weight and mammographic density among postmenopausal women in Sweden.. Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association of birth size measurements with mammographic density, ... | 178 | 23557241 | [
"5487448",
"16701509",
"13765757",
"25973484"
] | scientific_claim_retrieval | scientific |
d5d1603b4bc038fca5e1df832e85b0b2 | mteb/scifact | Sepsis related mortality has risen from 2009 to 2014. | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected b... | [
"Geovisual analytics to enhance spatial scan statistic interpretation: an analysis of U.S. cervical cancer mortality. BACKGROUND Kulldorff's spatial scan statistic and its software implementation - SaTScan - are widely used for detecting and evaluating geographic clusters. However, two issues make using the method ... | 1073 | 4824840 | [
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"5824985",
"5710820",
"6793674"
] | scientific_claim_retrieval | scientific |
63e06b8e28fea98d928b085e5b2e5de8 | mteb/scifact | RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells. | Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium. The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embry... | [
"Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment.. Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or disseminate... | 1004 | 301838 | [
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"39128592",
"33030946",
"20568364"
] | scientific_claim_retrieval | scientific |
2c6c92f5ac05744bdce84f26855fa997 | mteb/trec-covid | what is the origin of COVID-19 | PhEVER: a database for the global exploration of virus–host evolutionary relationships. Fast viral adaptation and the implication of this rapid evolution in the emergence of several new infectious diseases have turned this issue into a major challenge for various research domains. Indeed, viruses are involved in the de... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | b66bb2ri | [
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ebdbdbbc40dafe633d082dbb311e9335 | mteb/trec-covid | What are the impacts of COVID-19 among African-Americans that differ from the rest of the U.S. population? | Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors. Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally been neglected as tropical diseases primarily affecting African and South American regions. There are currently no FDA-approved vaccines for ... | [
"Immunosenescence Modulation by Vaccination. A decline in immune function is a hallmark of aging that leads to complicated illness from a variety of infectious diseases, cancer and other immune-mediated disorders, and may limit the ability to appropriately respond to vaccination. How vaccines might alter the senesc... | 41 | 59c9cpfe | [
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b748e6344c55f53c1eeaef0e5e912147 | mteb/scifact | Hypothalamic glutamate neurotransmission is unrelated to energy balance. | Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.. The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate ... | [
"In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus.. The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role... | 541 | 11886686 | [
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"4611267",
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] | scientific_claim_retrieval | scientific |
880b56440d374917149ce208df259ece | mteb/trec-covid | what are the initial symptoms of Covid-19? | Clinical aspects of virus/immune myocarditis. Although a cause-and-effect relationship between viral infection and myocarditis remains inferential, two distinct clinical syndromes can be identified. During the early viral phase, the cardiac manifestations emerge while the symptoms of active viral infection are also pre... | [
"Impact of Asymptomatic Bacteriuria (ASBU) Overtreatment During a Controlled Trial of Antimicrobial Stewardship (AS). BACKGROUND: What are the clinical profiles, outcomes, and antimicrobial costs attributed to patients admitted with presumed urinary tract infection (UTI) but deemed to have “no infection” (NI) by in... | 26 | 0jp0z5kp | [
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] | biomedical_literature_retrieval | scientific |
5196ad118a3a5a92685b3da7aa544645 | mteb/scifact | CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues. | CD28 and ITK signals regulate autoreactive T cell trafficking. Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic infi... | [
"Dendritic cells, T cells and lymphatics: dialogues in migration and beyond.. Immune cells continuously recirculate through lymph vessels en route from peripheral tissues to the blood. Leuyte trafficking into and within lymph vessels is mediated by an interply with lymphatic endothelial cells (LECs). However, lymph... | 201 | 2462673 | [
"46926352",
"3952288",
"39539647",
"2248870"
] | scientific_claim_retrieval | scientific |
560d1e0becc20017e1ac0ccc5d31782f | mteb/trec-covid | how long can the coronavirus live outside the body | Survival of Influenza A(H1N1) on Materials Found in Households: Implications for Infection Control. BACKGROUND: The majority of influenza transmission occurs in homes, schools and workplaces, where many frequently touched communal items are situated. However the importance of transmission via fomites is unclear since f... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | qz68gtd4 | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
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98fda7b3f17229f19eb867fd56dc31a3 | mteb/scifact | One in two surgical randomized controlled trials are discontinued early. | Discontinuation and non-publication of surgical randomised controlled trials: observational study. OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. DESIGN Cross sectional observational study of registered and published tr... | [
"Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques.. OBJECTIVE To assess the efficacy of various controlled ovarian hyperstimulation (COH) regimens in the prior poor-responder patient preparing for assisted reproductive techniques. DESIGN English-... | 886 | 6477536 | [
"8642784",
"33417012",
"15048300",
"25612629"
] | scientific_claim_retrieval | scientific |
dced2aaf74c496335c97beb345b1b236 | mteb/scifact | taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis. | TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development. Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental signals is a critical mechanism in the generation of this e... | [
"The emergence of order in the Drosophila pupal retina.. During pupation, long-range order is imposed on the autonomously developing ommatidia which compose the Drosophila eye. To accomplish this, eight additional cell types arise: the primary, secondary, and tertiary pigment cells, and the four cells that form the... | 1405 | 10504681 | [
"31761981",
"5002665",
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] | scientific_claim_retrieval | scientific |
fe9f653b456eb1d6c62b60c7d1f527cf | mteb/scifact | Gastric infection with Helicobacter pylori increases risk of gastric cancer in humans. | Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.. OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood... | [
"Helicobacter pylori AlpA and AlpB bind host laminin and influence gastric inflammation in gerbils.. Helicobacter pylori persistently colonizes humans, causing gastritis, ulcers, and gastric cancer. Adherence to the gastric epithelium has been shown to enhance inflammation, yet only a few H. pylori adhesins have be... | 448 | 2052720 | [
"26488879",
"22703082",
"39550665",
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] | scientific_claim_retrieval | scientific |
09c72be241847545a2bcbdac1992a987 | mteb/scifact | JMJD6 slows the hydroxylation of C-terminal lysine | JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is still not clearly defined and its biological function... | [
"Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity.. Recent studies have shown that the protein CTCF, which plays an important role in insulation and in large-scale organization of chromatin within the eukaryotic ... | 662 | 37204802 | [
"24995939",
"4402497",
"13907427",
"2316374"
] | scientific_claim_retrieval | scientific |
66ffde09accc7557e710433b828f8715 | mteb/scifact | Obesity decreases life quality. | Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.. BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studi... | [
"Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial.. BACKGROUND Laparoscopic adhesiolysis for chronic abdominal pain is controversial and is not evidence based. We aimed to test our hypothesis that laparoscopic adhesiolysis leads to substantial pai... | 871 | 195689316 | [
"3190689",
"5151024",
"24594624",
"2328272"
] | scientific_claim_retrieval | scientific |
16581b087d3867ebb4e9088c31069433 | mteb/scifact | Increased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm. | Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been com... | [
"Sympathetic baroreflex gain in normotensive pregnant women.. Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive ... | 607 | 4506414 | [
"18997216",
"12549585",
"24998764",
"44660616"
] | scientific_claim_retrieval | scientific |
fa91a13d859619a0beb23254d601c4b6 | mteb/scifact | Type 1 Diabetes is associated with subtle perturbations in T reg development. | Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires co... | [
"Autoimmunity due to molecular mimicry as a cause of neurological disease. One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothes... | 1334 | 13940200 | [
"5476778",
"266641",
"20344442",
"30805636"
] | scientific_claim_retrieval | scientific |
61e9c2db72219314f486e324f561e1ae | mteb/scifact | HIV trans-activator protein (TAT) effectively transports large and small molecules across cellular membranes into larger populations of neurons. | Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex. The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects. Here we report that inflammatory and neuropathic hypersensitivity can be suppres... | [
"Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication.. TLR3 has been implicated in the pathogenesis of several viral infections, including SIV- and HIV-1-induced inflammation and AIDS. However the molecu... | 489 | 6625693 | [
"25606339",
"1320137",
"22561064",
"2947540"
] | scientific_claim_retrieval | scientific |
4be5c1482d002901846b298c876088a0 | mteb/scifact | Having a main partner worsens HIV outcomes. | Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). D... | [
"Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease.. IMPORTANCE Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients. OBJECTIVE To test the hypothesis that elevated levels of inflammatory bio... | 498 | 17077004 | [
"29564505",
"21479231",
"24341590",
"5691302"
] | scientific_claim_retrieval | scientific |
a08bf75dd719722211042f9ffae4440e | mteb/scifact | A diminished ovarian reserve is a very strong indicator of infertility, even in an a priori non-infertile population. | Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age. Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective To determine the associations between biomarkers of ov... | [
"Reproductive and lifestyle determinants of anti-Müllerian hormone in a large population-based study.. CONTEXT Anti-müllerian hormone (AMH) is an ovarian reserve marker that is increasingly applied in clinical practice as a prognostic and diagnostic tool. Despite increased use of AMH in clinical practice, large-sca... | 40 | 13497630 | [
"42150015",
"15081770",
"44387884",
"24828165"
] | scientific_claim_retrieval | scientific |
f10fdd808e6dc94d4496471a9d0aaf18 | mteb/scifact | Helicobacter pylori-induced aberrant NF-kB-dependent expression of activation-induced cytidine deaminase contributes to the mutagenesis of host DNA. | Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPA... | [
"Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats... | 505 | 22703082 | [
"52873726",
"7465900",
"9614443",
"1887056"
] | scientific_claim_retrieval | scientific |
414f1e3c7c77c5671de877575834c811 | mteb/scifact | Taking 400mg of α-tocopheryl acetate does not prevent prostate cancer. | Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale ra... | [
"PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.. AMP-activated protein kinase (AMPK) is an energy-sensing enzyme whose activity is inhibited in settings of insulin resistance. Exposure to a high glucose concentration has recently been shown to incr... | 1139 | 12009265 | [
"23974474",
"31439189",
"8702697",
"32766786"
] | scientific_claim_retrieval | scientific |
ce8c7c24b94fd514638196cd4d37421c | mteb/scifact | Helminths interfere with immune system control of coinfections by microbial pathogens 16. | Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway. Tuberculosis and helminthic infections coexist in many parts of the world, yet the impact of helminth-elicited Th2 responses on the ability of the host to control Mycobacterium tubercul... | [
"Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.. Microbe-macrophage interactions play a central role in the pathogenesis of many infections. The ability of some bacterial pathogens to induce macrophage apoptosis has been suggested to contribute to their abi... | 506 | 7433668 | [
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"2604063",
"11899391"
] | scientific_claim_retrieval | scientific |
1bd7de13a2c264d7920ad9549b0a41cb | mteb/scifact | APOE4 expression in iPSC-derived neurons results in decreased tau phosphorylation. | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using hum... | [
"Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21. Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we rep... | 58 | 4709641 | [
"10641715",
"1701063",
"3113630",
"45764440"
] | scientific_claim_retrieval | scientific |
aa0f40a8b4bae4e8c600e5125857ef04 | mteb/scifact | A single nucleotide variant the gene DGKK is strongly associated with increased risk of hypospadias. | Common variants in DGKK are strongly associated with risk of hypospadias. Hypospadias is a common congenital malformation of the male external genitalia. We performed a genome-wide association study using pooled DNA from 436 individuals with hypospadias (cases) and 494 controls of European descent and selected the high... | [
"A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability. Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain the greater... | 46 | 380526 | [
"20280410",
"46277811",
"4465608",
"15570962"
] | scientific_claim_retrieval | scientific |
6494495d3de5e3bf1668b3084a29e9c9 | mteb/scifact | Women with a lower birth weight are more likely to develop breast cancer later in life. | Intrauterine environments and breast cancer risk: meta-analysis and systematic review. INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal en... | [
"Life course breast cancer risk factors and adult breast density (United Kingdom). Objective To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Se... | 1380 | 17450673 | [
"38784540",
"6327940",
"6748318",
"5487448"
] | scientific_claim_retrieval | scientific |
84971c3eaaffc503a95e6b8b7a173f04 | mteb/scifact | Genetic deficiency of mast cells leads to decreased weight gain in a mouse model of diet-induced obesity. | Deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common diseases such as multiple sclerosis, rheumatoid arthritis, at... | [
"Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to redu... | 458 | 597790 | [
"52865789",
"24347647",
"4709641",
"38025907"
] | scientific_claim_retrieval | scientific |
315326532ab5b1a52f90d0bb01ee5f77 | mteb/scifact | 4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers. | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an importan... | [
"Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and ... | 10 | 32587939 | [
"25510546",
"16546131",
"44562221",
"4399311"
] | scientific_claim_retrieval | scientific |
cba47a783a70aa3d20f25aa2564a8d83 | mteb/trec-covid | what are the transmission routes of coronavirus? | Role of air changes per hour (ACH) in possible transmission of airborne infections. The cost of nosocomial infections in the United States is estimated to be $4 billion to $5 billion annually. Applying a scientifically based analysis to disease transmission and performing a site specific risk analysis to determine the ... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | m6t1ggcy | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
89ea9b7377a4cd963cea736994691857 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetal brain. The cells of the central nervous system (CNS) have the peculiarity of physiologically expressing very low levels of HLA molecules. In multiple sclerosis (MS), however, as in endo... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | c5snhymz | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
f5f8066ae49f9e802d98e78c5a11545a | mteb/scifact | 90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma. | Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma.. IMPORTANCE The programmed death 1 (PD-1) pathway limits immune responses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab. OBJECTIVE To characterize the association of pembr... | [
"Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer. Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies. This raises fundamental questions about mechanisms of non-redundancy an... | 24 | 3471191 | [
"4468861",
"8963413",
"1900152",
"42731834"
] | scientific_claim_retrieval | scientific |
f2bfb623cb53c9589374acc75802ed70 | mteb/scifact | Charcoal is an effective treatment for acute paraquat poisoning. | Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.. BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best therapy... | [
"Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefor... | 245 | 8447873 | [
"12209494",
"19132741",
"13843341",
"116792"
] | scientific_claim_retrieval | scientific |
6fef94aa5b90fd3dba4fdf416da43ba7 | mteb/scifact | High levels of CRP lead to a higher risk of exacerbations in chronic obstructive pulmonary disease (COPD). | Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease.. IMPORTANCE Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients. OBJECTIVE To test the hypothesis that elevated levels of inflammatory biomarke... | [
"Who is where at risk for Chronic Obstructive Pulmonary Disease? A spatial epidemiological analysis of health insurance claims for COPD in Northeastern Germany. BACKGROUND Chronic obstructive pulmonary disease (COPD) has a high prevalence rate in Germany and a further increase is expected within the next years. Alt... | 515 | 29564505 | [
"3580005",
"21287352",
"3553087",
"26107000"
] | scientific_claim_retrieval | scientific |
9e5479dcabb63718dabd11b9ca333184 | mteb/scifact | BLM gene encodes RecQ-class DNA helicase. | The Bloom's syndrome gene product is homologous to RecQ helicases. The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been ass... | [
"The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. The product of the gene mutated in Bloom's syndrome, BLM, is a 3′–5′ DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption... | 157 | 13439128 | [
"16217855",
"13771184",
"2679511",
"25838286"
] | scientific_claim_retrieval | scientific |
45e71c8a77dd24605136438f18ecc96d | mteb/trec-covid | what is the origin of COVID-19 | Origins of MERS-CoV, and lessons for 2019-nCoV | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | gyj5213f | [
"o0syp1wb",
"hs2vni8z",
"35c6mak0",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
f29507b64c0ba3642a87bb861ecfc66d | mteb/scifact | Oxidative DNA damage inhibits STING signalling. | Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.. The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unc... | [
"A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion.. Cigarette smoke and smokeless tobacco extracts contain multiple carcinogenic compounds, but little is known about the mechanisms by which tumors develop and progress upon chronic exposure to carcinogens such as... | 899 | 5572127 | [
"1192458",
"13023410",
"4444861",
"1635872"
] | scientific_claim_retrieval | scientific |
a8892041b0acc32329232dc2e9857593 | mteb/scifact | FACT and other histone chaperone(s) compensate for Histone 2A (H2A)-histone 2B (H2B) dimer eviction during the histone exchange process. | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.. FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C termini of each subunit. Mutations through... | [
"A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.. Chromosome segregation during mitosis requires assembly of the kinetochore complex at the centromere. Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centr... | 407 | 9889151 | [
"5760247",
"24311787",
"5966635",
"29788648"
] | scientific_claim_retrieval | scientific |
8ec14e03d80c875ce9e154475125dc61 | mteb/scifact | Stacking is more stable when a purine is present in the +5 position (C1698). | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factor⋅G... | [
"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.. PURPOSE Glaucoma is the leading cause of global irreversible blindness. Present estimates of global glaucoma prevalence are not up-to-date and focused mainly on European ancestry populations. We s... | 1098 | 13552682 | [
"8298120",
"1006165",
"41264017",
"22191759"
] | scientific_claim_retrieval | scientific |
ae601807d8f8ad8508c02e2ec476436a | mteb/scifact | A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE). | BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS. In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their ... | [
"Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintai... | 28 | 12670680 | [
"14938990",
"696006",
"7115651",
"27466734"
] | scientific_claim_retrieval | scientific |
ec779f9b90f6c5aa9a553b5e4f0cf021 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Modeling the impact of quarantine during an outbreak of Ebola virus disease. The quarantine of people suspected of being exposed to an infectious agent is one of the most basic public health measure that has historically been used to combat the spread of communicable diseases in human communities. This study presents a... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | dr1ym2mb | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
9408f002e2566e4f5508fc25e9a12839 | mteb/scifact | Marmosets have a brain region homologous to Broca's area. | Responses of primate frontal cortex neurons during natural vocal communication.. The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization processing occurs in ventrolateral prefrontal cortex neurons, voc... | [
"Distinct Parietal and Temporal Pathways to the Homologues of Broca's Area in the Monkey. The homologues of the two distinct architectonic areas 44 and 45 that constitute the anterior language zone (Broca's region) in the human ventrolateral frontal lobe were recently established in the macaque monkey. Although we ... | 758 | 14195528 | [
"3095620",
"1391126",
"18379855",
"40769868"
] | scientific_claim_retrieval | scientific |
5cf564573ac558286f912a7a6f60cd23 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Epidemiology and Viral Etiology of the Influenza-Like Illness in Corsica during the 2012–2013 Winter: An Analysis of Several Sentinel Surveillance Systems. Influenza-like illness (ILI) surveillance is important to identify circulating and emerging/reemerging strains and unusual epidemiological trends. The present study... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | stuo7y2w | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
5260cb47e8892871b0b4a8d5d94be1f2 | mteb/scifact | Acute ablation of KRAS causes severe growth impairment. | Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.. Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhibitio... | [
"PGAP2 mutations, affecting the GPI-anchor-synthesis pathway, cause hyperphosphatasia with mental retardation syndrome.. Recently, mutations in genes involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor have been identified in a new subclass of congenital disorders of glycosylation (CDGs) w... | 80 | 4920376 | [
"26064942",
"9315213",
"10162553",
"25182647"
] | scientific_claim_retrieval | scientific |
d830930caa07552a08866a87d30b8565 | mteb/scifact | CCL19 is predominantly present within dLNs. | Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.. Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migration, ... | [
"Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers.. The lower respiratory tract of cigarette smokers contains an increased amount of iron that is predominantly sequestered within alveolar macrophages (AM), but is also present in alveolar epithelial fluid. Extracellular... | 199 | 2177022 | [
"25937484",
"10074251",
"2496002",
"21719289"
] | scientific_claim_retrieval | scientific |
26c7277c8725ee1ab08946177598ade0 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Rational hand hygiene during COVID-19 pandemic | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | gdtm4d7w | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
cf3b6034e6a839130eda54de67d0615b | mteb/scifact | Many cytokines that are produced by cancer cells also contribute to carcinogenesis. | Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development. It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor ... | [
"A primate virus generates transformed human cells by fusion. Amodel that explains both the origin and sporadic nature of cancer argues that cancer cells are a chance result of events that cause genomic and epigenetic variability. The prevailing view is that these events are mutations that affect chromosome segrega... | 755 | 17844478 | [
"10494012",
"17648235",
"31933981",
"2130391"
] | scientific_claim_retrieval | scientific |
ef2cc30d985b0da83f42ee01362c02b7 | mteb/scifact | PGE 2 suppresss intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. | Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unc... | [
"Stem cell-related \"self-renewal\" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.. PURPOSE Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregula... | 908 | 6923961 | [
"9486930",
"19683625",
"29366489",
"27123743"
] | scientific_claim_retrieval | scientific |
3f530710d582597545e9dccd4231ac86 | mteb/scifact | 70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics. | ABC of burns. Introduction.. Burns are one of the most devastating conditions encountered in medicine. The injury represents an assault on all aspects of the patient, from the physical to the psychological. It affects all ages, from babies to elderly people, and is a problem in both the developed and developing world. ... | [
"Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial. Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available ... | 21 | 41493639 | [
"3654468",
"45920278",
"24575065",
"6158879"
] | scientific_claim_retrieval | scientific |
d6cdb9da9576e184495904e7e4e11e59 | mteb/scifact | MafA phosphorylation decreases its ubiquitination. | GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-trans... | [
"The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation. TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of p... | 745 | 11291348 | [
"8698857",
"33068577",
"25328476",
"23974474"
] | scientific_claim_retrieval | scientific |
da9f4f56e273361507e8e541b7a7f39d | mteb/scifact | Exercise reduces cancer mortality rates among Chinese citizens. | Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study. BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple c... | [
"Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries.. OBJECTIVES To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and ... | 397 | 1456068 | [
"14700857",
"11630388",
"27240667",
"24341590"
] | scientific_claim_retrieval | scientific |
54e38f7108cbc30179652288be5246de | mteb/scifact | Inhibiting glucose-6-phospate dehydrogenase improves lipogenesis by deactivating LKB1-AMPK signaling. | 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling. The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis re... | [
"Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin in ischemic stroke is unclear. Here, we in... | 635 | 1686997 | [
"3761017",
"5108807",
"19205437",
"21931005"
] | scientific_claim_retrieval | scientific |
2a5b588f8dae16838e545458e6b2b051 | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, which ha... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | 72s8wpla | [
"jzlouns7",
"jc443w2a",
"9807pgmy",
"0smru5k2"
] | biomedical_literature_retrieval | scientific |
f9d2c6c6b764aa02c7a32c73e2f37403 | mteb/scifact | There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors. | An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells. Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent cell identity. Whereas the genomic locations of several pluripotency transcription factors have been reported, the spectrum of their interaction partners i... | [
"Bed sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case–control studies. OBJECTIVE To resolve uncertainty as to the risk of Sudden Infant Death Syndrome (SIDS) associated with sleeping in bed with your baby if neither parent smokes and the baby is breastfed. ... | 1294 | 30507607 | [
"20240998",
"13242763",
"21931005",
"12794099"
] | scientific_claim_retrieval | scientific |
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