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d5e4fa9d7b66303bcca08708c8a1277a | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | From severe acute respiratory syndrome-associated coronavirus to 2019 novel coronavirus outbreak: similarities in the early epidemics and prediction of future trends | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | ug6pare2 | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
e79f71c7e01db5389470c9afe623ce7c | mteb/scifact | Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed. | Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila. The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, cr... | [
"Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo.. Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate in this study that hematopoietic ... | 347 | 11902109 | [
"25148216",
"54561384",
"37699461",
"364522"
] | scientific_claim_retrieval | scientific |
3c09e32c45d67911c6f518796cf421e5 | mteb/trec-covid | what are the transmission routes of coronavirus? | Airplanes and Infectious Disease. Air travel is associated with crowded conditions that can facilitate the transmission of airborne infectious diseases. The risk of contracting such diseases depends on the presence of an infected person who is shedding infectious particles and sufficient exposure of a sensitive person ... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | vxjyjql6 | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
1f65b8e8bb37aee6b67ce6f8fed56f6b | mteb/scifact | Dexamethasone increases risk of postoperative bleeding. | Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.. CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric tonsillectomy. OBJECTIVE To assess whether dexamethasone dose-dependently reduces the risk ... | [
"Effect of hydroxyethyl starch on bleeding after cardiopulmonary bypass: a meta-analysis of randomized trials.. OBJECTIVE The effects of hydroxyethyl starch on bleeding after cardiopulmonary bypass were determined. METHODS A meta-analysis was performed of postoperative blood loss in randomized clinical trials of hy... | 339 | 23349986 | [
"36288526",
"46695481",
"14973286",
"34818263"
] | scientific_claim_retrieval | scientific |
74498d473e04b3bb219fda3d165ee069 | mteb/scifact | The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is independent of the patient's genetic make-up. | Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.. CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The f... | [
"Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion. Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that s... | 1260 | 24341590 | [
"13007205",
"24323369",
"5222182",
"20187433"
] | scientific_claim_retrieval | scientific |
69520faacc53014efd2f430cfd29c4a8 | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features. BACKGROUND: Study of drug-target interaction networks is an important topic for drug development. It is both time-consuming and costly to determine compound-protein interactions or potential drug-target interactions by exper... | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | ni6iyzdn | [
"6m06yzp7",
"njlqgih3",
"mw7athol",
"f089bs8r"
] | biomedical_literature_retrieval | scientific |
e984ef5ac3a1c9f60837735f446ccd8f | mteb/scifact | Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae. | Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae. DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break processi... | [
"Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae.. Various proteins have been found to play roles in both the repair of UV damaged DNA and heterochromatin-mediated silencing in the yeast Saccharomyces cerevisiae. In particular, factors that ... | 293 | 10874408 | [
"42267740",
"365896",
"41403996",
"23604601"
] | scientific_claim_retrieval | scientific |
ee67d8923ced14bb227211b2cb36d50b | mteb/scifact | Autophagy deficiency in the liver increases vulnerability to insulin resistance. | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-relat... | [
"Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.. The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity increases total JNK activity, and JNK1, but not JNK2, deficiency r... | 149 | 6227220 | [
"40090058",
"2481032",
"6277638",
"712078"
] | scientific_claim_retrieval | scientific |
6c29119878c4a5ebc08c337d4ef3dfae | mteb/scifact | Mouse models can be generated using "artificial spermatids." | Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, succes... | [
"Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.. Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists ... | 810 | 13513790 | [
"1616661",
"22490293",
"40127292",
"6588614"
] | scientific_claim_retrieval | scientific |
a032b28bd5b5af1b9a4a136715c526d1 | mteb/scifact | The HSV-2 infection is typically asymptomatic. | Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV... | [
"The Ratio of Monocytes to Lymphocytes in Peripheral Blood Correlates with Increased Susceptibility to Clinical Malaria in Kenyan Children. BACKGROUND Plasmodium falciparum malaria remains a major cause of illness and death in sub-Saharan Africa. Young children bear the brunt of the disease and though older childre... | 1168 | 8563659 | [
"13959707",
"12966719",
"23305884",
"13768432"
] | scientific_claim_retrieval | scientific |
254d38d16beafe8226a56867ad6d8dc7 | mteb/scifact | The most prevalent adverse events to Semaglutide are gastrointestinal. | Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial. Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an... | [
"Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis.. Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Due to long duration of therapy and concurrent use of multiple second-line drugs, adverse drug events (ADEs) are re... | 1238 | 3654468 | [
"11254040",
"583260",
"7583104",
"46277811"
] | scientific_claim_retrieval | scientific |
815d5eb25478a41b32037fab0ebd78c4 | mteb/scifact | Early patent ductus ateriosus (PDA) screening decreases in-hospital mortality. | Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.. IMPORTANCE There is currently no consensus for the screening and treatment of patent ductus arteriosus (PDA) in extremely preterm infants. Less pharmacological closure and more supportive managem... | [
"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.. BACKGROUND Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be ... | 367 | 27099731 | [
"34544514",
"25612629",
"7595742",
"25420421"
] | scientific_claim_retrieval | scientific |
d2383fcfd704472e220c35e404088e88 | mteb/scifact | The G34R/V mutation creates a hypomethylated phenotype at the H3K36 histone. | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation... | [
"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events ... | 1164 | 4455466 | [
"4312169",
"22482024",
"24770913",
"14610165"
] | scientific_claim_retrieval | scientific |
72ce36251b164816c1f5a1496f028115 | mteb/scifact | PrimPol generates short DNA replication intermediates on the leading strand during DNA replication. | PrimPol, an Archaic Primase/Polymerase Operating in Human Cells. We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides. Moreover, PrimPol is also a DNA polymerase tailored to bypass the most co... | [
"Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro.. The effects of topoisomerases I and II on the replication of SV40 DNA were examined using an in vitro replication system of purified proteins that constitutes the monopolymerase system. In the presen... | 970 | 17368516 | [
"11401602",
"15077696",
"2758012",
"16217855"
] | scientific_claim_retrieval | scientific |
1a1e790da650dd769b46068fd7aebebe | mteb/scifact | 7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults. | Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age. Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and mem... | [
"Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.. Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily ... | 19 | 3202143 | [
"13072113",
"41340212",
"24003461",
"9254550"
] | scientific_claim_retrieval | scientific |
d93d09e1e4d0a2ffc72456d4b29bd8da | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Is there a clinical difference between influenza A and B virus infections in hospitalized patients?: Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018. PURPOSE: The clinical presentation, complications and mortality in molecularly confirmed influenza A and B infe... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | a60nwtlf | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
cc9e9d38f087f8b68385467571a68124 | mteb/scifact | The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs). | The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.. Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. Howeve... | [
"CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. O... | 1181 | 2734421 | [
"3531388",
"10162553",
"13989491",
"18414462"
] | scientific_claim_retrieval | scientific |
ce541986568c9b894addedaacb5a228b | mteb/scifact | The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs). | The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.. The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to lau... | [
"CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. O... | 1181 | 39128592 | [
"3531388",
"10162553",
"13989491",
"18414462"
] | scientific_claim_retrieval | scientific |
e7506b496b93768ff0d5cf172a169ecb | mteb/scifact | Tonic signaling from the scFv prevents constitutive stimulation. | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors. Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains un... | [
"Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals. Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related... | 1309 | 18231807 | [
"30303335",
"1049501",
"32598644",
"2436602"
] | scientific_claim_retrieval | scientific |
d12721af75043d35e31f438200b48273 | mteb/scifact | Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules. | The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly.. Human mitochondrial ribosomes are specialized in the synthesis of 13 proteins, which are fundamental components of the oxidative phosphorylation system. The pathway of mitoribosome biogenesis, the compartment... | [
"Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Post-transcriptional modification of RNA nucleosides occurs in all living organisms. Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabili... | 962 | 4306711 | [
"984825",
"20018321",
"11484808",
"25799020"
] | scientific_claim_retrieval | scientific |
6890e4e4a71b736c9274907337d31789 | mteb/scifact | The risk of female prisoners harming themselves is ten times that of male prisoners. | Self-harm in prisons in England and Wales: an epidemiological study of prevalence, risk factors, clustering, and subsequent suicide. BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding... | [
"Evaluation of cortical bone by peripheral quantitative computed tomography in renal transplant recipients.. BACKGROUND The absolute risk of fractures in renal transplant patients is 3 times that of matched controls. Most of the symptomatic fractures are peripheral, suggesting a greater compromise of cortical bone.... | 1269 | 13900610 | [
"24724242",
"12443371",
"14843502",
"25300664"
] | scientific_claim_retrieval | scientific |
2d5f463007f286ce4690e21c4385aac5 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | The Role of Chemokines during Viral Infection of the CNS | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 1gad01re | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
eb858d38efd195854488b84dcd642e3f | mteb/scifact | A strong bias in the phage genome locations where the spacers were derived has been observed in many CRISPR subtypes that confer the immunity to phage. | Strong bias in the bacterial CRISPR elements that confer immunity to phage.. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems provide adaptive immunity against phage via spacer-encoded CRISPR RNAs that are complementary to invasive nucleic acids. Here, we challenge Streptococcus thermophil... | [
"Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes.. Mosquito-borne viruses cause significant levels of morbidity and mortality in humans and domesticated animals. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle that involves alternating virus ... | 47 | 26996935 | [
"9539248",
"368506",
"1332250",
"26133404"
] | scientific_claim_retrieval | scientific |
a1e58dbb6875c6bc1de3887f372c3a9b | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high ca... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | k8wo636m | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
c60c762b5de7598909375d436f1f5fe8 | mteb/scifact | Notch signaling occurs between tumor cells and stromal cells. | Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.. While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regarding contact-dependent signals that promote tumor angiogenes... | [
"BRAF mutation predicts for MEK-dependence in non-small cell lung cancer (NSCLC).. 5247 Constitutive ERK signaling is common in human cancer and is often the result of activating mutations of BRAF, RAS and upstream receptor tyrosine kinases. Missense BRAF kinase domain mutations are frequently observed in melanoma,... | 863 | 20568364 | [
"85665741",
"26735905",
"9831859",
"23509593"
] | scientific_claim_retrieval | scientific |
65103cc8dd35ee30a8a6df0ea26b99e9 | mteb/scifact | The amount of publicly available DNA data doubles every 10 months. | The EMBL nucleotide sequence database.. The EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl. html ) constitutes Europe's primary nucleotide sequence resource. DNA and RNA sequences are directly submitted from researchers and genome sequencing groups and collected from the scientific literature and patent a... | [
"Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.. BACKGROUND Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE) inhibitors are known to reduce proteinuria. Their combination ... | 1190 | 30655442 | [
"25816994",
"3662132",
"3471191",
"27768226"
] | scientific_claim_retrieval | scientific |
62e121e522ba9cca5fb91495e9811845 | mteb/scifact | Pyridostatin induces checkpoint activation. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.. DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the ... | 996 | 16472469 | [
"38131471",
"1595617",
"2033917",
"7736860"
] | scientific_claim_retrieval | scientific |
b4db8fcb946420cc42d648e672ae747b | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Wearing face masks in public during the influenza season may reflect other positive hygiene practices in Japan. BACKGROUND: Although the wearing of face masks in public has not been recommended for preventing influenza, these devices are often worn in many Asian countries during the influenza season. In Japan, it is th... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | baxxcyji | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
a2398c885b0ecd667e568da03b697ec6 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Respiratory Pathogens. Respiratory tract infections are among the most common presenting complaints of patients in both hospital and community settings. They are a considerable burden in terms of both patient morbidity and public health interventions. Laboratory diagnosis of respiratory tract infections should provide ... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | awanrm9u | [
"6324190r",
"ukqvhzws",
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"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
0426e5477a1a0e30027c44a62574dcbc | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | New evidence-based clinical practice guideline timely supports hospital infection control of coronavirus disease 2019 | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | uwhi9pbq | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
bf5878a873939e32d2d05204dd255e96 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Role of the Renin-Angiotensin System in ARDS. The renin-angiotensin system (RAS) is a powerful biological system that plays an important role in regulation of systemic blood pressure through the maintenance of fluid and salt homeostasis. It is a multifactorial system since it includes different components (Fig. 1): The... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | i5n3i2cy | [
"mx4t6s6n",
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"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
33b39511ef8e2e1e33e6c51d532145f8 | mteb/scifact | MT binding domain drives amyloid structure formation. | Cryo-EM structures of Tau filaments from Alzheimer’s disease brain. Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesion... | [
"Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores ... | 739 | 4446814 | [
"2617858",
"6788835",
"23342686",
"9889151"
] | scientific_claim_retrieval | scientific |
562e5e2f2dd45f520dcf1eaea14a419e | mteb/scifact | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial.. BACKGROUND Human papillomavirus (HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (C... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 972 | 27873158 | [
"6561200",
"16980892",
"76415938",
"46355579"
] | scientific_claim_retrieval | scientific |
3012d3232655d5b2a8e5891c3e6426ce | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Demographic, etiological, and histological pulmonary analysis of patients with acute respiratory failure: a study of 19 years of autopsies. INTRODUCTION: Acute respiratory failure has been one of the most important causes of death in intensive care units, and certain aspects of its pulmonary pathology are currently unk... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | dy21jno8 | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
5e6748ce158dea7d845f63ae1108ab5d | mteb/scifact | Nonsteroidal antinflammatory drugs are ineffective as cancer treatments. | Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.. IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from... | [
"Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Despite progress in the development of drugs that efficiently target cancer cells, treatments for metastatic tumours are often ineffective. The now well-established dependency of cancer cells on their microenvironment suggests that... | 856 | 43334921 | [
"878526",
"6407356",
"5271210",
"9791313"
] | scientific_claim_retrieval | scientific |
0d460f38f126d849cc5f3f805e0d624e | mteb/scifact | Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers. | Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.. Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here w... | [
"Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of plur... | 530 | 25413327 | [
"3360421",
"32797183",
"11335860",
"26374799"
] | scientific_claim_retrieval | scientific |
d5429ba38f202d61b036d0e54f6d63a4 | mteb/scifact | Expression of oncolytic virus antigens as peptides permits additional protection against relapse. | Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence. Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors. This phenotype allows them to evade... | [
"Fingolimod provides long-term protection in rodent models of cerebral ischemia.. OBJECTIVE The sphingosine-1-phosphate (S1P) receptor agonist fingolimod (FTY720), that has shown efficacy in advanced multiple sclerosis clinical trials, decreases reperfusion injury in heart, liver, and kidney. We therefore tested th... | 404 | 1921218 | [
"33884866",
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"10190778",
"10450300"
] | scientific_claim_retrieval | scientific |
3d3c19d8e92d4985b25deb85b0e17752 | mteb/scifact | The recruitment of Wdr5 to its target loci depends on Kat8. | The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.. Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid response to differentiation cues. Both ESC features are subject to epigenetic regulation. Here we show that the histone... | [
"DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a centra... | 1258 | 12040627 | [
"9393969",
"23938319",
"2192419",
"10189634"
] | scientific_claim_retrieval | scientific |
68bc4dc3a34584c63a72c936614bdb07 | mteb/scifact | Whole brain radiotherapy increases the occurrence of new brain metastases. | Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.. CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has ... | [
"The cost effectiveness of stereotactic radiosurgery versus surgical resection in the treatment of solitary metastatic brain tumors.. Solitary metastatic brain tumors are the most common intracranial neoplasms encountered by neurosurgeons. Surgical resection of brain metastasis with whole brain radiotherapy (WBR) s... | 1376 | 3944632 | [
"11117498",
"23639838",
"22185730",
"32250572"
] | scientific_claim_retrieval | scientific |
5a6b24dae09e3441eff1bf0542dae2d9 | mteb/scifact | Gpr124 suppresses BBB breakdown in mouse models of ischemic stroke. | Gpr124 is essential for blood–brain barrier integrity in central nervous system disease. Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupl... | [
"The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis. Although the etiology of multiple sclerosis (MS) remains enigmatic, the role of T cells is unquestionably central in this pathology. Immune cells respond to pathogens and danger ... | 480 | 6325527 | [
"52095986",
"33884866",
"2774906",
"24142891"
] | scientific_claim_retrieval | scientific |
fd45f32f4000acf1945f17ffa5ed4bcd | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Differential diagnosis of pandemic (H1N1) 2009 infection by detection of haemagglutinin with an enzyme-linked immunoassay. A sensitive and convenient immunoassay that can directly differentiate pandemic (H1N1) 2009 (pH1N1) virus from seasonal influenza virus can play an important role in the clinic. In the presented st... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | yw2dawdc | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
05fe6bf1783cfb1c4974963140f01339 | mteb/scifact | Ribosomal protein (RP) expression is controlled in part by stress-activated regulators. | The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.. The rapamycin-sensitive TOR signalling pathway in Saccharomyces cerevisiae activates a cell-growth program in response to nutrients such as nitrogen and carbon. The TOR1 and TOR2 kinases (TOR) control cytoplasmic prot... | [
"Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 dir... | 1046 | 4324278 | [
"17055665",
"16527698",
"4795303",
"1605392"
] | scientific_claim_retrieval | scientific |
2bab34da29d3b317543d18084b73d2c1 | mteb/scifact | The minor G allele of FOXO3 up-regulates IL-10. | Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but i... | [
"Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10.. Cytomegalovirus (CMV) has highly evolved mechanisms for avoiding detection by the host immune system. Recently, in the genomes of human and primate CMV, a novel gene comprising segments of noncontiguous open reading frames was identifi... | 1234 | 13905670 | [
"37762357",
"16119973",
"7221410",
"46451940"
] | scientific_claim_retrieval | scientific |
9e30bfe5ce8c05ae1bb4e209e44cf65c | mteb/scifact | Sympathetic nerve activity is elevated throughout normal pregnancy. | Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.. BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE). It is unknown whether sympathetic drive is altered in normal pregnancy, ... | [
"Sympathetic activation during early pregnancy in humans.. Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity develops early during pregnancy, remaining high throu... | 1119 | 5323845 | [
"26710772",
"20418809",
"42441846",
"4409524"
] | scientific_claim_retrieval | scientific |
792df3c866aa78fd65183378c04120a1 | mteb/trec-covid | how long can the coronavirus live outside the body | Survival of Viruses in the Marine Environment. It has been well established that human pathogenic viruses may be transmitted through the marine environment due to the release of sewage by polluted rivers, outfalls, or release from vessels. These wastes contain human enteric viruses, which if ingested, or in some cases ... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | n7mhwjiw | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
473be190503533eca628a5079efd066b | mteb/scifact | Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes. | Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss. Histone variants help specialize chromatin regions; however, their impact on transcriptional regulation is largely unknown. Here, we determined the genome-wide localization and dynamics of Htz1... | [
"Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome. Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes wi... | 1040 | 16626264 | [
"9451052",
"1259280",
"5966635",
"11844791"
] | scientific_claim_retrieval | scientific |
a4c827df6899b4b734add85dcf7eef43 | mteb/scifact | There is no known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors. | Oct4 links multiple epigenetic pathways to the pluripotency network. Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-... | [
"Bed sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case–control studies. OBJECTIVE To resolve uncertainty as to the risk of Sudden Infant Death Syndrome (SIDS) associated with sleeping in bed with your baby if neither parent smokes and the baby is breastfed. ... | 1294 | 2078658 | [
"20240998",
"13242763",
"21931005",
"12794099"
] | scientific_claim_retrieval | scientific |
db9464f292a9ee27df30636954660d2c | mteb/scifact | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme.. OBJECTIVE To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compare... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 973 | 27446873 | [
"6561200",
"19140422",
"16980892",
"76415938"
] | scientific_claim_retrieval | scientific |
791511c0e94924e3e282092c39c42923 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Accurate ranking of influential spreaders in networks based on dynamically asymmetric link weights. We propose an efficient and accurate measure for ranking spreaders and identifying the influential ones in spreading processes in networks. While the edges determine the connections among the nodes, their specific role i... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | jjw560vw | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
042800805045c1574c8232ac0e81e578 | mteb/scifact | In rhesus macaques, daily subcutaneous injections of emtricitabine are ineffective at protecting against rectally transmitted simian-human immunodeficiency virus. | Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir. BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with antiret... | [
"Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.. HIV continues to spread globally, mainly through sexual contact. Despite advances in treatment and care, preventing transmission with vaccines or microbicides has proven difficult. A promising strategy to avoid transmission i... | 582 | 14260013 | [
"708425",
"4373433",
"20864487",
"7111021"
] | scientific_claim_retrieval | scientific |
6d5ee923dc835a79174ff6ac78dd42c0 | mteb/scifact | Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines. | KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods for c... | [
"Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction. Virally induced inflammatory responses, beta cell destruction and release of beta cell autoantigens may lead to autoimmune reactions culminating in type 1 diabetes. Therefore, viral capability to induce beta cell death ... | 258 | 22080671 | [
"6144969",
"27403802",
"343052",
"17412260"
] | scientific_claim_retrieval | scientific |
5d6605f5f71712b6ba406c6a843ebfa0 | mteb/scifact | Sudden death can occur in patients with complex ventricular arrhythmias. | Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.. BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart fai... | [
"Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease.. PURPOSE To identify factors affecting the short-term prognosis of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS The 590 patients having COPD as primar... | 1111 | 1686881 | [
"2032877",
"19368793",
"13768432",
"12225214"
] | scientific_claim_retrieval | scientific |
05bdf8aa0fd763407fb7787bc51705ee | mteb/scifact | PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice. | Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for ... | [
"Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.. People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting neurotransmission and signalling pathways that govern brain function are also evident. A large number of genes are simultan... | 912 | 11254556 | [
"11992632",
"14188138",
"10790846",
"33792330"
] | scientific_claim_retrieval | scientific |
a6b57aa0d24666be822897ff45c13fb7 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Monoclonal antibodies against bovine immunoglobulins and their use in isotype-specific ELISAs for rotavirus antibody. Monoclonal antibodies (MCA) against bovine immunoglobulin (BIg) isotypes were produced and characterized. MCAs were obtained which react specifically with IgG, IgG(1), IgG(2) or IgA while MCAs against I... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | n8viusan | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
23ec788c4da30203e10dfb37ba4f2481 | mteb/scifact | Bcp1 is a chaperone for Rpl23. | Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics. Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. ... | [
"Biochemical studies on Mycobacterium tuberculosis UreG and comparative modeling reveal structural and functional conservation among the bacterial UreG family.. Nickel is a fundamental micronutrient for cellular life, but it is toxic in soluble form at nonphysiological concentrations. Such potentially contradictory... | 173 | 8126244 | [
"38805486",
"37164306",
"25510546",
"1084345"
] | scientific_claim_retrieval | scientific |
a970b694e8667278d6217bb16cb0048e | mteb/scifact | Moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD). | Life is sweet: candy consumption and longevity.. Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however, clinical trials have not supported this.1 Candy—sugar con... | [
"Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults.. CONTEXT Population surveys indicate that physical activity levels are low in the United States. One consequence of inactivity, low cardiorespiratory fitness, is an established risk factor for cardiovascula... | 799 | 5293024 | [
"13230773",
"14803797",
"5939172",
"17914395"
] | scientific_claim_retrieval | scientific |
2467c241cd726e77f9b84df82d92645c | mteb/scifact | Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs. | Localization and requirement for Myosin II at the dorsal-ventral compartment boundary of the Drosophila wing.. As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries have been discovered in a wide variety of tis... | [
"An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos. Partitioning tissues into compartments that do not intermix is essential for the correct morphogenesis of animal embryos and organs. Several hypotheses have been proposed to explain compartmental cell sorting, mainl... | 355 | 38380061 | [
"13936152",
"16280642",
"15790930",
"17731780"
] | scientific_claim_retrieval | scientific |
94e3280126107fa06cdf10bec15f616d | mteb/scifact | LDL cholesterol has a causal role in the development of cardiovascular disease. | LDL-cholesterol concentrations: a genome-wide association study. BACKGROUND LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets.... | [
"Report of the National Heart, Lung, and Blood Institute Workshop on Lipoprotein(a) and Cardiovascular Disease: recent advances and future directions.. It has been estimated that approximately 37% of the US population judged to be at high risk for developing coronary artery disease (CAD), based on the National Chol... | 673 | 2095573 | [
"7757997",
"11899391",
"29735200",
"5612738"
] | scientific_claim_retrieval | scientific |
6c683abf2139c743d9343d80f3d2f56c | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | On Temporal Patterns and Circulation of Influenza Virus Strains in Taiwan, 2008-2014: Implications of 2009 pH1N1 Pandemic. BACKGROUND: It has been observed that, historically, strains of pandemic influenza led to succeeding seasonal waves, albeit with decidedly different patterns. Recent studies suggest that the 2009 A... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | e1aodl9u | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
d0f2f4ae1ef1aa1a155ada6f7d53d52a | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | Trajectories of School Recovery After a Natural Disaster: Risk and Protective Factors. Disasters may have significant and lasting impacts on educational programs and academic achievement, yet the examination of differing patterns of school recovery after disasters is understudied. This paper focused on two aims: (i) id... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | tz28lzi2 | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
feaf0393dbf6b6ed6b8a9f5632c56474 | mteb/scifact | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | Determinants of adolescent physical activity and inactivity patterns.. OBJECTIVES Despite recognition of the important influence of environmental determinants on physical activity patterns, minimal empirical research has been done to assess the impact of environmental/contextual determinants of physical activity. This ... | [
"Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity.. Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasi... | 946 | 13083189 | [
"11201004",
"52865789",
"39390206",
"41976370"
] | scientific_claim_retrieval | scientific |
edba4c6905c69a199e3ff8753dd02ce3 | mteb/scifact | Students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers. | Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study. OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct. DESIGN Matched case-control study. Setting Records ... | [
"The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group.. OBJECTIVE The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent devel... | 1105 | 6710713 | [
"24704139",
"30058568",
"18734652",
"13933299"
] | scientific_claim_retrieval | scientific |
ef5f53cd81d9f6a26b23b63b8253da5f | mteb/scifact | Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers. | Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.. Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells ha... | [
"Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of plur... | 530 | 36651210 | [
"3360421",
"32797183",
"11335860",
"26374799"
] | scientific_claim_retrieval | scientific |
fcba69531502abc0c45ed6e2d795e04d | mteb/scifact | The proliferative capacity of neural progenitors differs across species. | 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.. Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical pr... | [
"Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration.. Zebrafish maintain a greater capacity than mammals for central nervous system repair after injury. Understanding differences in regenerative responses between different vertebrate species may shed light on ... | 1254 | 16939583 | [
"5395426",
"4951831",
"39465575",
"313394"
] | scientific_claim_retrieval | scientific |
1058ff29ee784aa248b203390c567c99 | mteb/scifact | Klf2 is important for proper myeloid cell function. | The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.. Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify t... | [
"Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2.. Objective. Chemotherapeutic agents function by inducing apoptosis and their effectiveness depends on the balance of pro- and anti-apoptotic proteins in cells. Due to the compl... | 667 | 6493422 | [
"11900630",
"10354110",
"18450716",
"22210434"
] | scientific_claim_retrieval | scientific |
23bebad6736d94781e28f6986a49cb04 | mteb/scifact | Rapamycin increases the concentration of triacylglycerols in fruit flies. | Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR k... | [
"British Journal of Nutrition (2003), 89, 295–301 q The Authors 2003 DOI: 10.1079/BJN2002776 Plasma homocysteine concentration is decreased by dietary intervention*. High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum f... | 1016 | 6277638 | [
"18557974",
"12903921",
"1733337",
"23974474"
] | scientific_claim_retrieval | scientific |
9f240264db031c76bcb95d5000b715a1 | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Noninvasive ventilation in acute respiratory failure due to H1N1 influenza: A word of caution | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | uvv06b4n | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
6f5ada7c5df48b41c0dc7725889dbeeb | mteb/scifact | Scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder. | Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patien... | [
"Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques.. OBJECTIVE To assess the efficacy of various controlled ovarian hyperstimulation (COH) regimens in the prior poor-responder patient preparing for assisted reproductive techniques. DESIGN English-... | 1069 | 4200695 | [
"8642784",
"7751726",
"38623601",
"53779698"
] | scientific_claim_retrieval | scientific |
4c0073b33719baacaa74d894b6a962c4 | mteb/scifact | PCSK9 inhibitors decrease plasma Lp(a) levels. | Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have ... | [
"Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.. Bile acids are recognized as metabolic modulators. The present study was aimed at evaluating the effects of a potent Asbt inhibitor (264W94), which blocks intestinal absorption of bile acids, on glucose homeostasis in Z... | 901 | 6540064 | [
"12280462",
"25822299",
"25014337",
"23577867"
] | scientific_claim_retrieval | scientific |
5debf75d4fe9b3bfa98b9fc3bdc86b97 | mteb/scifact | Elevated cell-free mitochondrial DNA levels are associated with mortality. | Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation. BACKGROUND Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We h... | [
"Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.. Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to as oxidative stress, represents a potentially toxic insult which if not counteracted will lead to membr... | 375 | 1522647 | [
"25488034",
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"26068103",
"43880096"
] | scientific_claim_retrieval | scientific |
f8899343a11748fddb8764063f708ace | mteb/scifact | Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss. | Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice ... | [
"Summary. The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which ... | 325 | 40349336 | [
"14178995",
"12909503",
"13791206",
"36310858"
] | scientific_claim_retrieval | scientific |
5f57090de9894e5df944f0161381d5ce | mteb/scifact | Type 1 Diabetes is associated with subtle perturbations in T reg development. | Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with different... | [
"Autoimmunity due to molecular mimicry as a cause of neurological disease. One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothes... | 1334 | 13923140 | [
"5476778",
"266641",
"20344442",
"30805636"
] | scientific_claim_retrieval | scientific |
4b9906e9b0faeb87f936f627cfe595e7 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapy | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | bs7vh557 | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
e78e4b02ba761432fe9b35271b595a12 | mteb/scifact | Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation. | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia. Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in... | [
"PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.. Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphat... | 1027 | 3113630 | [
"22185730",
"32598644",
"14405193",
"3973445"
] | scientific_claim_retrieval | scientific |
81b0218a97a358fa49c3eb5f5a8e598e | mteb/scifact | Activation of PPM1D enhances p53 function. | Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliom... | [
"The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells.. The inflammasome is a proteolysis complex that generates the active forms of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Inflammasome activation is mediat... | 69 | 5956380 | [
"15435343",
"23912923",
"21295300",
"23700330"
] | scientific_claim_retrieval | scientific |
51ac82112d6f921cd7c86a08169c0324 | mteb/scifact | GATA3 regulates cell cycle progression in bone marrow hematopoietic stem cells. | GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.. Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD4... | [
"Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche. The quiescent state is thought to be an indispensable property for the maintenance of hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as the stem cell niches, is ... | 444 | 10165258 | [
"17271462",
"20186814",
"3391547",
"16361581"
] | scientific_claim_retrieval | scientific |
7e67a52123d55842368d8f90f37b2c18 | mteb/scifact | 53% of perinatal mortality is due to low birth weight. | Estimates of global prevalence of childhood underweight in 1990 and 2015.. CONTEXT One key target of the United Nations Millennium Development goals is to reduce the prevalence of underweight among children younger than 5 years by half between 1990 and 2015. OBJECTIVE To estimate trends in childhood underweight by geog... | [
"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.. BACKGROUND Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be ... | 17 | 1606628 | [
"34544514",
"9967265",
"7662395",
"35495268"
] | scientific_claim_retrieval | scientific |
8a6b673fc42bfb788caba56fa05fe19d | mteb/scifact | Intramembrane cleavage by signal peptide peptidase aids in the degradation of proteins with a complex membrane orientation. | Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.. The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome. Still, however, little is known about the components med... | [
"Structural Studies of a Four-MBT Repeat Protein MBTD1. BACKGROUND The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of transcriptional repression of developmental control genes... | 657 | 8533245 | [
"3829232",
"30884033",
"4429388",
"12197393"
] | scientific_claim_retrieval | scientific |
fd3669854e10493343dfe507f45dd0aa | mteb/scifact | Increased mobility of retrotransposons does not lead to mutation and higher tumorigenesis rates. | The DNA Methylome of Human Peripheral Blood Mononuclear Cells. DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequen... | [
"YOKO HONDA AND SHUJI HONDA 1. Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal... | 616 | 18670 | [
"14864285",
"28707489",
"26059876",
"8906858"
] | scientific_claim_retrieval | scientific |
a25757f4cbaa36504e45d3f6ba05aaf2 | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Critical Care Pandemic Preparedness Primer. The first half decade of the 21(st) century has brought with it infectious outbreaks such as severe acute respiratory syndrome (SARS) [1], bioterrorism attacks with anthrax [2], and the spread of H5N1 influenza A in birds across Asia and Europe [3, 4] sparking concerns remini... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | tevw83ju | [
"jzlouns7",
"jc443w2a",
"9807pgmy",
"0smru5k2"
] | biomedical_literature_retrieval | scientific |
899c3ca61cfd9457668d9805fa0ee2e0 | mteb/scifact | Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy. | Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.. IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; com... | [
"Nortriptyline for smoking cessation: a review.. This article reviews the efficacy of nortriptyline for smoking cessation based on a meta-analysis of the Cochrane Library. Six placebo-controlled trials have shown nortriptyline (75-100 mg) doubles quit rates (OR = 2.1). Between 4% and 12% of smokers dropped out beca... | 272 | 11614737 | [
"5551138",
"5114940",
"8570690",
"21700295"
] | scientific_claim_retrieval | scientific |
e97664546be7ce5f73f4429acfe41509 | mteb/scifact | Varying expression levels of EBI2 affect the positioning and migration of B cells. | 7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases. EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection. After it was reported in 2009 that the receptor playe... | [
"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.. Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high... | 1361 | 15058155 | [
"38587347",
"14615911",
"2086909",
"9558539"
] | scientific_claim_retrieval | scientific |
f41833f7fa6eedb681067297abb91fb3 | mteb/scifact | Localization of PIN1 in the roots of Arabidopsis requires VPS9a | Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions. Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication—a vital feature of multicellular development. Efflux carriers for the signalling molecul... | [
"CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs. We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization re... | 703 | 4350400 | [
"12871002",
"21307488",
"10790846",
"13231899"
] | scientific_claim_retrieval | scientific |
5ab318a731b4a15f05a8d06e579e2c0e | mteb/trec-covid | How has the COVID-19 pandemic impacted mental health? | Patients with mental health disorders in the COVID-19 epidemic | [
"What Effect Did the Global Financial Crisis Have Upon Youth Wellbeing? Evidence From Four Australian Cohorts. Recent research has suggested significant negative effects of the Global Financial Crisis (GFC) on mental health and wellbeing. In this article, the authors suggest that the developmental period of late ad... | 45 | 5rbp00g6 | [
"35c6mak0",
"nbjili3v",
"hmh4s3w4",
"cf39dhpo"
] | biomedical_literature_retrieval | scientific |
fd3271ff5ad818b8b6af932747e74ffa | mteb/trec-covid | what are the initial symptoms of Covid-19? | Pneumonia Caused by Emerging Viral Agents. Emerging viruses that cause pneumonia in humans are agents which normally circulate in the animal population but can move to human hosts under certain circumstances, which determines the occurrence of a new type of disease. The Middle East respiratory syndrome (MERS) is caused... | [
"Impact of Asymptomatic Bacteriuria (ASBU) Overtreatment During a Controlled Trial of Antimicrobial Stewardship (AS). BACKGROUND: What are the clinical profiles, outcomes, and antimicrobial costs attributed to patients admitted with presumed urinary tract infection (UTI) but deemed to have “no infection” (NI) by in... | 26 | e9ix35x3 | [
"s5mcgocf",
"beqvgdjo",
"gwnjl686",
"cz85adrw"
] | biomedical_literature_retrieval | scientific |
acdfeb85f68ef6ec33ae0a407b35ebba | mteb/scifact | Eilat virus (EILV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in nonhuman primates. | A chikungunya fever vaccine utilizing an insect-specific virus platform. Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inability ... | [
"Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage. Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To e... | 372 | 24922825 | [
"3566945",
"22937651",
"38376189",
"8883846"
] | scientific_claim_retrieval | scientific |
e418ab9becc86ec2181b1d38b32f44ae | mteb/scifact | Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients. | Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodg... | [
"Shared and distinct genetic variants in type 1 diabetes and celiac disease.. BACKGROUND Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whethe... | 1333 | 1649738 | [
"25571386",
"3619931",
"13969173",
"27260630"
] | scientific_claim_retrieval | scientific |
1ad5c6aa1563266db528fa1cf57c3a5f | mteb/scifact | Physical activity level has no association with the difference in maximal oxygen consumption between black and white youth. | Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.. CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different ethn... | [
"Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children. The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether i... | 945 | 8428935 | [
"18537148",
"11201004",
"24746892",
"8595678"
] | scientific_claim_retrieval | scientific |
9cf137abe2c17115d76a24a45c0d5293 | mteb/scifact | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut. | Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immunodefic... | [
"Isolation from African Sykes' monkeys (Cercopithecus mitis) of a lentivirus related to human and simian immunodeficiency viruses.. Analysis of serum samples from 100 wild-caught or colony-born Sykes' monkeys (Cercopithecus mitis) in Kenya revealed that 59 animals had antibodies cross-reactive to human immunodefici... | 333 | 29023309 | [
"798152",
"19005293",
"40323148",
"22705234"
] | scientific_claim_retrieval | scientific |
3d6bb962bdc4761ba7beb551b3f9fc39 | mteb/scifact | Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells. | Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions. The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses. The goal... | [
"Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection.. OBJECTIVE To define the impact of chronic viremia and associated immune activation on B-cell exhaustion in HIV infection. DESIGN Progressive HIV infection is marked by B-cell anergy and exhaustion coupled with dramatic hy... | 259 | 8883846 | [
"20261352",
"4387484",
"23848916",
"20960682"
] | scientific_claim_retrieval | scientific |
61e7412cfe6e878fe04637f2b023fa8a | mteb/scifact | RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells. | The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.. Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. Howeve... | [
"Control of central and peripheral tolerance by Aire.. The negative selection of self-reactive thymocytes depends on the expression of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even ... | 1005 | 2734421 | [
"39559521",
"13989491",
"10162553",
"17844478"
] | scientific_claim_retrieval | scientific |
f5724a553d90d4c7e473dcb6245759f6 | mteb/trec-covid | what evidence is there for dexamethasone as a treatment for COVID-19? | Glucocorticoids in the treatment of acute respiratory distress syndrome. Acute respiratory distress syndrome (ARDS) is characterized by local inflammation and an intense systemic inflammatory reaction. Glucocorticoid administration has been suggested due to their anti-inflammatory properties. However, results from the ... | [
"Soluble immune checkpoints in cancer: production, function and biological significance. Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based on this, monoclonal antibodies are having much rapid d... | 46 | hipvvezt | [
"d3d1n9qa",
"36gbl7tu",
"72s8wpla",
"cpjlzutk"
] | biomedical_literature_retrieval | scientific |
58cfd43ab83d511312d7ac2c9cd422fe | mteb/scifact | Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE. | Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice. Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport. Indiv... | [
"Characterization of prostaglandin E2 production by Candida albicans.. Candida albicans produces lipid metabolites that are functionally similar to host prostaglandins. These studies, using mass spectrometry, demonstrate that C. albicans produces authentic prostaglandin E(2) (PGE(2)) from arachidonic acid. Maximal ... | 316 | 712078 | [
"2443495",
"20732789",
"10430148",
"25028913"
] | scientific_claim_retrieval | scientific |
aea7a54b38a693e616d1a81df29aa445 | mteb/scifact | Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS. | Induction of myelodysplasia by myeloid-derived suppressor cells.. Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective hematopoiesis. Here we report that myeloid-derived suppressor cells (MDSC), which are classicall... | [
"MicroRNA Response of Primary Human Macrophages to Arcobacter Butzleri Infection. The role of microRNAs (miRNAs) in infectious diseases is becoming more and more apparent, and the use of miRNAs as a diagnostic tool and their therapeutic application has become the major focus of investigation. The aim of this study ... | 1306 | 5836 | [
"14362780",
"17023584",
"25606339",
"9159125"
] | scientific_claim_retrieval | scientific |
d8b6c4f1d31bdbb5a859d3192e1d7ed0 | mteb/trec-covid | how has COVID-19 affected Canada | El síndrome respiratorio agudo grave: primera pandemia del siglo XXI | [
"Effects of memory on the shapes of simple outbreak trees. Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link phylogenetic trees to patterns of transmission. Particularly in bacteria that cause chroni... | 9 | 1fqbis7e | [
"mcdfcc8v",
"78395e3t",
"iwu022jh",
"44mvuunh"
] | biomedical_literature_retrieval | scientific |
899439ddb771877969444e0677982ca7 | mteb/scifact | The DESMOND program demonstrates no significant impact on weight loss. | Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care. OBJECTIVE To measure whether the benefits of a single education and self management structured programme ... | [
"Transtheoretical model-based multiple behavior intervention for weight management: effectiveness on a population basis.. BACKGROUND The increasing prevalence of overweight and obesity underscores the need for evidence-based, easily disseminable interventions for weight management that can be delivered on a populat... | 1159 | 12584053 | [
"6841927",
"23573229",
"36288526",
"1507222"
] | scientific_claim_retrieval | scientific |
a168f5098a4369f6613b9a6c6f804c94 | mteb/scifact | Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis. | the Development of Autoimmune Myocarditis in Mice by an. BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and Resul... | [
"Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.. V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous studies using a VI... | 780 | 8246922 | [
"23912923",
"17223891",
"17967608",
"5811042"
] | scientific_claim_retrieval | scientific |
a1ce65ebb8e8704816a791e854659d56 | mteb/scifact | Primary cervical cytology screening with HPV detection has higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology. | Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial.. BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV ... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 973 | 9764256 | [
"6561200",
"19140422",
"16980892",
"76415938"
] | scientific_claim_retrieval | scientific |
9c315cfa3d6ae6e925a3e26a9524c0fe | mteb/scifact | CDK6 shows impaired binding to loss-of-function variants of p18 INK4C. | Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development. We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconsti... | [
"Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.. Microbial survival in a host is usually dependent on the ability of a pathogen to undergo changes that promote escape from host defense mechanisms. The human-pathogenic fungus Cryptococcus neofor... | 204 | 7898952 | [
"7717468",
"23698769",
"24311787",
"857189"
] | scientific_claim_retrieval | scientific |
c4600099ff5f42e4b0f55a18f9199da1 | mteb/trec-covid | has social distancing had an impact on slowing the spread of COVID-19? | Understanding the Impact of Face Mask Usage Through Epidemic Simulation of Large Social Networks. Evidence from the 2003 SARS epidemic and 2009 H1N1 pandemic shows that face masks can be an effective non-pharmaceutical intervention in minimizing the spread of airborne viruses. Recent studies have shown that using face ... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 10 | 14x4uqq7 | [
"72s8wpla",
"37ojix5j",
"h51zr96k",
"w5fxen70"
] | biomedical_literature_retrieval | scientific |
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