text stringlengths 105 13.7k | label int64 0 1 | label_text stringclasses 2
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Phosphoinositide phospholipase C (PLC, EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl--myo-inositol-4,5-bisphosphate inositoltris... | 1 | Gene expression + Signal Transduction |
According to the IUPAC definition, flocculation is "a process of contact and adhesion whereby the particles of a dispersion form larger-size clusters". Flocculation
is synonymous with agglomeration and coagulation/coalescence.
Basically, coagulation is a process of addition of coagulant to destabilize a stabilized char... | 0 | Metallurgy |
The first suggestion of ADP-ribosylation surfaced during the early 1960s. At this time, Pierre Chambon and coworkers observed the incorporation of ATP into hen liver nuclei extract. After extensive studies on the acid insoluble fraction, several different research laboratories were able to identify ADP-ribose, derived ... | 1 | Gene expression + Signal Transduction |
One of the major issues that hinders the ncRNA therapy is the stability of the single stranded RNA molecule. RNA is typically single stranded therefore slightly unstable as compared to dsDNA molecules. This however can be overcome by fabricating the single stranded RNA to double stranded RNA(dsRNA). This is quite effec... | 1 | Gene expression + Signal Transduction |
Pack cementation is a widely used CVD technique that consists of immersing the components to be coated in a metal powder mixture and ammonium halide activators and sealing them in a retort. The entire apparatus is placed inside a furnace and heated in a protective atmosphere to a lower than normal temperature that allo... | 0 | Metallurgy |
The borax method of gold extraction has been used by artisanal gold miners in the Benguet area north of Manila in the Philippines for more than 30 years. Some believe it was in practice as early as the 1900s. The method is increasingly being seen as a safe alternative to the widespread use of toxic mercury in artisana... | 0 | Metallurgy |
Archaeometallurgical study has many uses in both the chemical and anthropological fields. Analysis contributes valuable insights into many archaeological questions, from technological choice to social organisation. Any project concerned with the relationship that the human species has had to the metals known to us is a... | 0 | Metallurgy |
cAMP is associated with kinases function in several biochemical processes, including the regulation of glycogen, sugar, and lipid metabolism.
In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally inactive as a tetrameric holoenzyme, consisting of two cat... | 1 | Gene expression + Signal Transduction |
In this example, the following sequence is a region of the human mitochondrial genome with the two overlapping genes MT-ATP8 and MT-ATP6.
When read from the beginning, these codons make sense to a ribosome and can be translated into amino acids (AA) under the vertebrate mitochondrial code:
|Start|AAC GAA AAT CTG TTC G... | 1 | Gene expression + Signal Transduction |
Iron smelting—the extraction of usable metal from oxidized iron ores—is more difficult than tin and copper smelting. While these metals and their alloys can be cold-worked or melted in relatively simple furnaces (such as the kilns used for pottery) and cast into molds, smelted iron requires hot-working and can be melte... | 0 | Metallurgy |
There are a few limitations of detonation spraying, these are:
* Detonation spraying creates a coating that is mostly mechanically bonded as opposed to being metallurgically bonded, which is a much stronger type of bond.
* Detonation spraying is a line of sight process meaning that components generally need to be coate... | 0 | Metallurgy |
In addition to activating PKC, diacylglycerol has a number of other functions in the cell:
* a source for prostaglandins
* a precursor of the endocannabinoid 2-arachidonoylglycerol
* an activator of a subfamily of transient receptor potential canonical (TRPC) cation channels, TRPC3/6/7. | 1 | Gene expression + Signal Transduction |
LacI finds its target operator DNA surprisingly fast. In vitro the search is 10-100 times faster than the theoretical upper limit for two particles searching for each other via diffusion in three dimensions (3D). To explain the fast search, it was hypothesized that LacI and other transcription factors (TFs) find their ... | 1 | Gene expression + Signal Transduction |
Chemical milling is normally performed in a series of five steps: cleaning, masking, scribing, etching, and demasking. [https://www.youtube.com/watch?v=YtnUZanxtLs Video of chemical milling process] [https://www.fotofab.com/photo-etching-process/ Learn more about the video] | 0 | Metallurgy |
RNAP was discovered independently by Charles Loe, Audrey Stevens, and Jerard Hurwitz in 1960. By this time, one half of the 1959 Nobel Prize in Medicine had been awarded to Severo Ochoa for the discovery of what was believed to be RNAP, but instead turned out to be polynucleotide phosphorylase. | 1 | Gene expression + Signal Transduction |
The explorations in the foothills of the Kopetdag revealed well developed irrigation systems with water control arrangements which resulted in prosperous, well settled large regional centres. The largest of these settlements is Namazga-Tepe with an area of 50 ha. The excavations done at this site lead to the discovery ... | 0 | Metallurgy |
Adenylate-uridylate-rich elements (AU-rich elements; AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors, and cytokines. AREs are one of the most common determinants of RNA stability in mammalian cells.
AREs are defined as a reg... | 1 | Gene expression + Signal Transduction |
One of the earliest smelted iron artifacts, a dagger with an iron blade found in a Hattic tomb in Anatolia, dated from 2500 BC. About 1500 BC, increasing numbers of non-meteoritic, smelted iron objects appeared in Mesopotamia, Anatolia and Egypt. Nineteen meteoric iron objects were found in the tomb of Egyptian ruler T... | 0 | Metallurgy |
Sand casting has many defects that can occur due to the mould failing. The mould usually fails because of one of two reasons: the wrong material is used or it is improperly rammed.
The first type is mould erosion, which is the wearing away of the mould as the liquid metal fills the mould. This type of defect usually on... | 0 | Metallurgy |
While the mechanical behavior of ceramics is often dominated by flaws, i.e. porosity, instead of grain size, grain-size strengthening is also observed in high-density ceramic specimens. Additionally, nanocrystalline ceramics have been shown to sinter more rapidly than bulk ceramics, leading to higher densities and impr... | 0 | Metallurgy |
Self-cleaning screen media was initially engineered to resolve screen cloth blinding, clogging and pegging problems. The idea was to place crimped wires side by side on a flat surface, creating openings and then, in some way, holding them together over the support bars (crown bars or bucker bars). This would allow the ... | 0 | Metallurgy |
A key concept that might be used for applications is the (numerical) derivative of the solid fraction fs with temperature. A numerical example using a copper zinc alloy at composition Zn 30% in weight is proposed as an example here using the opposite sign for using both temperature and its derivative in the same grap... | 0 | Metallurgy |
Spalling is a common mechanism of rock weathering, and occurs at the surface of a rock when there are large shear stresses under the surface. This form of mechanical weathering can be caused by freezing and thawing, unloading, thermal expansion and contraction, or salt deposition. | 0 | Metallurgy |
Circle-Throw Vibrating Equipment is a shaker or a series of shakers as to where the drive causes the whole structure to move. The structure extends to a maximum throw or length and then contracts to a base state. A pattern of springs are situated below the structure to where there is vibration and shock absorption as... | 0 | Metallurgy |
Smaller arc furnaces may be adequately cooled by circulation of air over structural elements of the shell and roof, but larger installations require intensive forced cooling to maintain the structure within safe operating limits. The furnace shell and roof may be cooled either by water circulated through pipes which fo... | 0 | Metallurgy |
Uncontrolled growth is a necessary step for the development of all cancers. In many cancers (e.g. melanoma), a defect in the MAP/ERK pathway leads to that uncontrolled growth. Many compounds can inhibit steps in the MAP/ERK pathway, and therefore are potential drugs for treating cancer, such as Hodgkin disease.
The fi... | 1 | Gene expression + Signal Transduction |
The following genes are analogous or homologous between Drosophila melanogaster (in bold) and human TNFR1 signalling:
* Imd: human orthologue = RIP1
* Tak1: human orthologue = Tak1
* TAB2: human orthologue = TAB2
* Dredd: human orthologue = caspase-8
* FADD: human orthologue = FADD
* Key/Ikkγ: human orthologue = NEMO
*... | 1 | Gene expression + Signal Transduction |
The nucleolus within the nucleus can be targeted with a sequence called a nucleolar localization signal (abbreviated NoLS or NOS). | 1 | Gene expression + Signal Transduction |
HMG proteins are thought to play a significant role in various human disorders. Disruptions and rearrangements in the genes coding for some of the HMG proteins are associated with some common benign tumors. Antibodies to HMG proteins are found in patients with autoimmune diseases. The SRY gene on the Y Chromosome, resp... | 1 | Gene expression + Signal Transduction |
High-carbon steel has approximately 0.6 to 1.0% carbon content. It is very strong, used for springs, edged tools, and high-strength wires. | 0 | Metallurgy |
Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins. | 1 | Gene expression + Signal Transduction |
The CAG promoter is a strong synthetic promoter frequently used to drive high levels of gene expression in mammalian expression vectors.
CAG promoter was constructed in the lab of Dr Jun-ichi Miyazaki from the following sequences:
:(C) the cytomegalovirus (CMV) early enhancer element,
:(A) the promoter, the first exo... | 1 | Gene expression + Signal Transduction |
A key characteristic of amorphous brazing foils (ABFs) is their relatively low melting points, which typically range from 830 to 1200°C. This attribute is crucial for their application as filler metals in brazing. Due to their ductility and flexibility, ABFs present a viable alternative to filler metals in paste or pow... | 0 | Metallurgy |
The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade
that involves the Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib.
It may refer to the PI3K/AKT pathway.
It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.
The anti-a... | 1 | Gene expression + Signal Transduction |
Clustering of genes in prokaryotes was known for a long time. Their genes are grouped in operons, genes within operons share a common promoter unit. These genes are mostly functionally related. The genome of prokaryotes is relatively very simple and compact. In eukaryotes the genome is huge and only a small amount of i... | 1 | Gene expression + Signal Transduction |
The rusting of iron is an electrochemical process that begins with the transfer of electrons from iron to oxygen. The iron is the reducing agent (gives up electrons) while the oxygen is the oxidizing agent (gains electrons). The rate of corrosion is affected by water and accelerated by electrolytes, as illustrated by t... | 0 | Metallurgy |
The processive polyadenylation complex in the nucleus of eukaryotes works on products of RNA polymerase II, such as precursor mRNA. Here, a multi-protein complex (see components on the right) cleaves the 3′-most part of a newly produced RNA and polyadenylates the end produced by this cleavage. The cleavage is catalysed... | 1 | Gene expression + Signal Transduction |
ASF/SF2 has been shown to interact with:
* CDC5L,
* CLK1,
* PSIP1,
* SFRS2,
* SRPK1,
* SRPK2,
* TOP1,
* U2 small nuclear RNA auxiliary factor 1, and
* snRNP70. | 1 | Gene expression + Signal Transduction |
The GAIN domain (G-protein-coupled receptor (GPCR) autoproteolysis-inducing domain) is a protein domain found in a number of cell surface receptors, including adhesion-GPCRs and polycystic kidney disease proteins PKD1 and PKD2. The domain is involved in the self-cleavage of these transmembrane receptors, and has been s... | 1 | Gene expression + Signal Transduction |
Coherent grain boundaries are those in which the crystal lattice of adjacent grains is continuous across the boundary. In other words, the crystallographic orientation of the grains on either side of the boundary is related by a small rotation or translation. Coherent grain boundaries are typically observed in material... | 0 | Metallurgy |
The D-gun atomises the powder feedstock into extremely small particles (80–95% of particles by total number are of size <100 nm). This means proper extraction facilities are required for inhalation safety purposes. Also isolation of the D-gun is recommended to avoid operators breathing in the dangerous dust and fumes. ... | 0 | Metallurgy |
Since multiple studies have shown that RNA Pol II can be found at a very large number of extragenic regions, it is possible that eRNAs simply represent the product of random “leaky” transcription and carry no functional significance. The non-specific activity of RNA Pol II would therefore allow extragenic transcription... | 1 | Gene expression + Signal Transduction |
It is crucial to note that although most of the gene deserts explored here are essential, it could be that the majority of the contents in gene deserts are still likely to be inessential and disposable. Naturally, this is not to say that the roles that gene deserts play are inessential or unimportant, rather than their... | 1 | Gene expression + Signal Transduction |
Up-regulated expression of genes in mammals can be initiated when signals are transmitted to the promoters associated with the genes. Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fol... | 1 | Gene expression + Signal Transduction |
Several, so-called mTOR/PI3K dual inhibitors (TPdIs), have been developed and are in early-stage preclinical trials and show promising results. Their development has been benefited from previous studies with PI3K-selective inhibitors. The activity of these small molecules from rapalog activity differs in the way by blo... | 1 | Gene expression + Signal Transduction |
After the war, Birger Solberg resumed control, but the economics and equipment of the facility had become unfavorable. Feeling empathy for the former workers, he devised a new business plan based on collecting German plane wrecks and other debris in middle-Norway and re-melting them.
The facility was closed on December... | 0 | Metallurgy |
In 1964 Impalco decided to offer Fulmer for sale.
At that time Dr (later Sir) James Taylor, who was Chairman of Imperial Metal Industries (IMI), was also the Honorary Treasurer of the Institute of Physics and the Physical Society (IOP). He proposed that IOP should acquire Fulmer and thus become the first Learned Societ... | 0 | Metallurgy |
A third element was presently supplied in the rich repertory of decorative motives, Egyptian and Assyrian, that was brought to Europe by Phoenician traders or fetched from Asia by adventurous Greeks. A vast amount of oriental merchandise found its way into Greece and Italy around 800 BC. There is some uncertainty about... | 0 | Metallurgy |
There are many types of defects which result from many different causes. Some of the solutions to certain defects can be the cause for another type of defect.
The following defects can occur in sand castings. Most of these also occur in other casting processes. | 0 | Metallurgy |
Grev Brook; Bill Bowyer; David Davies; Mike Dewey; Bill Flavell; Philipp Gross; Eddie Sugars; GI Williams | 0 | Metallurgy |
Fas ligand or FasL is a type II transmembrane protein belonging to the tumor necrosis factor superfamily (TNFSF). It is homotrimeric, which means it consists of three identical polypeptides. It has a long cytoplasmic domain, a stalk region, a transmembrane domain (TM), a TNF homology domain (THD) responsible for the ho... | 1 | Gene expression + Signal Transduction |
The Wohlwill process is an industrial-scale chemical procedure used to refine gold to the highest degree of purity (99.999%). The process was invented in 1874 by Emil Wohlwill. This electrochemical process involves using a cast gold ingot, often called a doré bar, of 95%+ gold to serve as an anode. Lower percentages of... | 0 | Metallurgy |
In soldering metals, flux serves a threefold purpose: it removes any oxidized metal from the surfaces to be soldered, seals out air thus preventing further oxidation, and improves the wetting characteristics of the liquid solder. Some fluxes are corrosive, so the parts have to be cleaned with a damp sponge or other abs... | 0 | Metallurgy |
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription st... | 1 | Gene expression + Signal Transduction |
Steel which utilizes the EPS process to remove surface scale shows few differences from steel which utilizes acid pickling to remove surface scale. "Downstream" industrial processes such as galvanizing, cold reducing and painting of EPS-processed steel strip show it to be interchangeable with acid-pickled steel strip. ... | 0 | Metallurgy |
Immediate manifestations of caustic substance ingestions include erosions of mucosal surfaces of the gastrointestinal tract or airway (which can cause bleeding if the erosions extend to a blood vessel), mouth and tongue swelling, drooling or hypersalivation, nausea, vomiting, dyspnea, dysphonia/aphonia irritation of th... | 0 | Metallurgy |
Sources of manganese ore generally also contain iron oxides. As manganese is harder to reduce than iron, during the reduction of manganese ore, iron is also reduced and mixed with the manganese in the melt, unlike other oxides such as SiO, AlO and CaO.
Reduction is achieved using a submerged arc furnance. There are two... | 0 | Metallurgy |
* Williams, H. (trans.), A sixteenth-century German treatise: Von Stahel und Eysen. 1532, Technical studies in the field of the fine arts, 4.2 (October, 1935), 63-92.
* Smith, Cyril Stanley (ed.), Sources for the History of the Science of Steel, 1532-1786, Society for the History of Technology, 4 (Cambridge, Mass.: Soc... | 0 | Metallurgy |
The noble metals are siderophiles (iron-lovers). They tend to sink into the Earth's core because they dissolve readily in iron either as solid solutions or in the molten state. Most siderophile elements have practically no affinity whatsoever for oxygen: indeed, oxides of gold are thermodynamically unstable with respec... | 0 | Metallurgy |
ECgene in computational biology is a database of genomic annotations taking alternative splicing events into consideration. | 1 | Gene expression + Signal Transduction |
There may be a general misconception between the term corrosion inspection and corrosion monitoring, but inspection means frequent checkpoints to check for changes or deviations from predicted results, while corrosion monitoring is a continuous check to control and act quickly against change. In inspection, the purpose... | 0 | Metallurgy |
Archaeometallurgy is the study of the past use and production of metals by humans. It is a sub-discipline of archaeology and archaeological science. | 0 | Metallurgy |
(p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides, are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. This inhibition by (p)ppGpp decreases translation in the cell, conserving am... | 1 | Gene expression + Signal Transduction |
In metallurgy, solid solution strengthening is a type of alloying that can be used to improve the strength of a pure metal. The technique works by adding atoms of one element (the alloying element) to the crystalline lattice of another element (the base metal), forming a solid solution. The local nonuniformity in the l... | 0 | Metallurgy |
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Cleavage factors are two closely associated protein complexes involved in the cleavage of the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule in the process of gene transcription. The cleavage is the first step in adding a polyadenine tail to the pre-mRNA, which is one of the n... | 1 | Gene expression + Signal Transduction |
In addition to the role of the lactate shuttle in supplying NAD+ substrate for β-oxidation in the peroxisomes, the shuttle also regulates FFA mobilization by controlling plasma lactate levels. Research has demonstrated that lactate functions to inhibit lipolysis in fat cells through activation of an orphan G-protein c... | 1 | Gene expression + Signal Transduction |
Transvection is an epigenetic phenomenon that results from an interaction between an allele on one chromosome and the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. It can also occur between nonallelic regions of the genome as well as regions of the gen... | 1 | Gene expression + Signal Transduction |
A boundary can be described by the orientation of the boundary to the two grains and the 3-D rotation required to bring the grains into coincidence. Thus a boundary has 5 macroscopic degrees of freedom. However, it is common to describe a boundary only as the orientation relationship of the neighbouring grains. General... | 0 | Metallurgy |
The Euglena photoreceptor was identified as a blue-light-activated adenylyl cyclase. Excitation of this receptor protein results in the formation of cyclic adenosine monophosphate (cAMP) as a second messenger. Chemical signal transduction ultimately triggers changes in flagellar beat patterns and cell movement.
The arc... | 1 | Gene expression + Signal Transduction |
SMAs find a variety of applications in civil structures such as bridges and buildings. In the form of rebars or plates, they can be used for flexural, shear and seismic strengthening of concrete and steel structures. Another application is Intelligent Reinforced Concrete (IRC), which incorporates SMA wires embedded wit... | 0 | Metallurgy |
The first stage is called roughing, which produces a rougher concentrate. The objective is to remove the maximum amount of the valuable mineral at as coarse a particle size as practical. Grinding costs energy. The goal is to release enough gangue from the valuable mineral to get a high recovery. Some concentrators use ... | 0 | Metallurgy |
* bicarbonate derived from carbonic anhydrase (CA)-dependent hydration.
* CO metabolism
* Enters through membrane-transporting proteins or cystic fibrosis transmembrane conductance regulators.
* Calcium enters by voltage-dependent Ca channels or by release from the endoplasmic reticulum.
* Hydrogencarbonate and calcium... | 1 | Gene expression + Signal Transduction |
Because the ligaments of these materials are essentially small metallic samples, they are themselves expected to be quite ductile; although, the entire nano-porous material is often observed to be brittle in tension. Dislocation behavior is extensive within the ligaments (just as would be expected in a metal): a high d... | 0 | Metallurgy |
Depletion gilding is a method for producing a layer of nearly pure gold on an object made of gold alloy by removing the other metals from its surface. It is sometimes referred to as a "surface enrichment" process. | 0 | Metallurgy |
A coin assayer is often assigned to each mint or assay office to determine and assure that all coins produced at the mint have the correct content or purity of each metal specified, usually by law, to be contained in them. This was particularly important when gold and silver coins were produced for circulation and used... | 0 | Metallurgy |
Hydrogen forms whenever molten aluminium comes into contact with water vapor, and easily dissolves into the melt. The gas tends to come out of the solution and forms bubbles when the melt solidifies.
The detrimental effects arising from the presence of an excess of dissolved hydrogen in aluminium are numerous. Hydrogen... | 0 | Metallurgy |
The elements of a eukaryotic and prokaryotic 5′ UTR differ greatly. The prokaryotic 5′ UTR contains a ribosome binding site (RBS), also known as the Shine–Dalgarno sequence (AGGAGGU), which is usually 3–10 base pairs upstream from the initiation codon. In contrast, the eukaryotic 5′ UTR contains the Kozak consensus seq... | 1 | Gene expression + Signal Transduction |
CK1δ and CK1ε have been shown to be relevant in human disease. Recent findings indicate that pharmaceutical inhibition of CK1 may be a promising therapeutic for aberrant circadian rhythm. Mutations and variants of the CK1ε phosphorylation site of PER2 are associated with cases of Familial Advanced Sleep Phase Syndrome ... | 1 | Gene expression + Signal Transduction |
The Scythians emerged as a people prior to the 7th Century BC, when they were first mentioned in historical records. The Scythian civilization consisted of a number of distinct tribal groups scattered across the Pontic Steppes, Caucasus, and Central Asia. Though primarily a nomadic people, the Scythians established a n... | 0 | Metallurgy |
Sigma B was the first anti-sigma factor identified in a bacterium. It is found in Bacillus subtilis and other similar bacteria. Sigma B is a stress response factor that plays a role in survival and against destruction that could be caused by other organisms such as mammals. General stress responses that are controlled... | 1 | Gene expression + Signal Transduction |
Taking results gathered largely from ‘real world’ exposure sites, automotive companies, led originally by the Japanese automobile industry, developed their own Cyclic Corrosion Tests. These have evolved in different ways for different vehicle manufacturers, and such tests still remain largely industry specific, with no... | 0 | Metallurgy |
Further alloys with low melting points are at , at and at . The alloy consisting of 40.8 % caesium, 11.8 % sodium and 47.4 % potassium has a melting point of . | 0 | Metallurgy |
As outlined above, the Kidd Process did not use wax on its permanent cathodes. This highlighted disadvantages associated with the use of wax by the Isa Process. Cathode copper consumers applied pressure to producers to remove residual wax from the cathode copper, and the use of wax also created “housekeeping” problems ... | 0 | Metallurgy |
Histone methylation was initially considered an effectively irreversible process as the half-life of the histone methylation was approximately equal to the histone half-life. Histone lysine demethylase LSD1 (later classified as KDM1A) was first identified in 2004 as a nuclear amine oxidase homolog. Two main classes of... | 1 | Gene expression + Signal Transduction |
TFIIIB remains bound to DNA following the initiation of transcription by Pol III, unlike bacterial σ factors and most of the basal transcription factors for Pol II transcription. This leads to a high rate of transcriptional reinitiation of Pol III-transcribed genes. One study conducted on Saccharomyces cerevisiae found... | 1 | Gene expression + Signal Transduction |
The grain macrostructure in ingots and most castings have three distinct regions or zones: the chill zone, columnar zone, and equiaxed zone. The image below depicts these zones.
The chill zone is named so because it occurs at the walls of the mold where the wall chills the material. Here is where the nucleation phase o... | 0 | Metallurgy |
The process begins by preparing the puddling furnace. This involves bringing the furnace to a low temperature and then fettling it. Fettling is the process of painting the grate and walls around it with iron oxides, typically hematite; this acts as a protective coating keeping the melted metal from burning through the ... | 0 | Metallurgy |
This is the most common use for galvanized metal, and hundreds of thousands of tons of steel products are galvanized annually worldwide. In developed countries most larger cities have several galvanizing factories, and many items of steel manufacture are galvanized for protection. Typically these include: street furnit... | 0 | Metallurgy |
Figure 2 illustrates the most common type of DDRNAI DNA construct, designed to express a shRNA. This figure consists of a promoter sequence driving the expression of sense and antisense sequences separated by a loop sequence, followed by a transcriptional terminator. The antisense sequence processed from the shRNA can ... | 1 | Gene expression + Signal Transduction |
Trans-regulatory elements (TRE) are DNA sequences encoding upstream regulators (ie. trans-acting factors), which may modify or regulate the expression of distant genes. Trans-acting factors interact with cis-regulatory elements to regulate gene expression. TRE mediates expression profiles of a large number of genes via... | 1 | Gene expression + Signal Transduction |
The physical presence of introns promotes cellular resistance to starvation via intron enhanced repression of ribosomal protein genes of nutrient-sensing pathways. | 1 | Gene expression + Signal Transduction |
One challenge when synthesising a metallic glass is that the techniques often only produce very small samples, due to the need for high cooling rates. 3D-printing methods have been suggested as a method to create larger bulk samples. Selective laser melting (SLM) is one example of an additive manufacturing method that ... | 0 | Metallurgy |
Discovered in 1953 by Jacques Monod and colleagues, the trp operon in E. coli was the first repressible operon to be discovered. While the lac operon can be activated by a chemical (allolactose), the tryptophan (Trp) operon is inhibited by a chemical (tryptophan). This operon contains five structural genes: trp E, tr... | 1 | Gene expression + Signal Transduction |
GenePattern is a freely available computational biology open-source software package originally created and developed at the Broad Institute for the analysis of genomic data. Designed to enable researchers to develop, capture, and reproduce genomic analysis methodologies, GenePattern was first released in 2004. GenePat... | 1 | Gene expression + Signal Transduction |
RNA editing through the addition and deletion of uracil has been found in kinetoplasts from the mitochondria of Trypanosoma brucei.
Because this may involve a large fraction of the sites in a gene, it is sometimes called "pan-editing" to distinguish it from topical editing of one or a few sites.
Pan-editing starts with... | 1 | Gene expression + Signal Transduction |
E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.
TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few trans... | 1 | Gene expression + Signal Transduction |
The red component of color television cathode ray tubes is typically emitted from an yttria () or yttrium oxide sulfide () host lattice doped with europium (III) cation (Eu) phosphors. The red color itself is emitted from the europium while the yttrium collects energy from the electron gun and passes it to the phosphor... | 0 | Metallurgy |
* Chromatin structure oriented factors:<br />(HMTs (Histone MethylTransferases)):<br /> COMPASS§† – (COMplex of Proteins ASsociated with Set1) – Methylates lysine 4 of histone H3: Is responsible of repression/silencing of transcription. A normal part of cell growth and transcription regulation within RNAP II.
* Set2 – ... | 1 | Gene expression + Signal Transduction |
Morpholinos do not trigger the degradation of their target RNA molecules, unlike many antisense structural types (e.g., phosphorothioates, siRNA). Instead, Morpholinos act by "steric blocking", binding to a target sequence within an RNA, inhibiting molecules that might otherwise interact with the RNA. Morpholino oligos... | 1 | Gene expression + Signal Transduction |
The process of splat quenching involves rapid quenching or cooling of molten metal. A typical procedure for splat quenching involves pouring the molten metal between two cooled copper rollers that are circulated with water to transfer the heat away from the metal, causing it to almost instantaneously solidify.
A more e... | 0 | Metallurgy |
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