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While the synthesis of nanocrystalline feedstocks in the form of foils, powders, and wires is relatively straightforward, the tendency of nanocrystalline feedstocks to coarsen upon extended exposure to elevated temperatures means that low-temperature and rapid densification techniques are necessary to consolidate these... | 0 | Metallurgy |
Induction heating is a non contact heating process which uses the principle of electromagnetism induction to produce heat in a work-piece. In this case thermal expansion is used in a mechanical application to fit parts over one another, e.g. a bushing can be fitted over a shaft by making its inner diameter slightly sma... | 0 | Metallurgy |
Marion Katherine Blight was born in Watford in 1921. Her mother worked in domestic service while her father was a shop assistant. McQuillan attended Wycombe High School before getting a scholarship to Henrietta Barnett’s School. McQuillan went to University in 1939 where she graduated from Girton College, Cambridge wit... | 0 | Metallurgy |
The Wilfley Table is commonly used for the concentration of heavy minerals from the laboratory up to the industrial scale. It has a traditional shaking (oscillating) table design with a riffled deck. It is one of several brands of wet tables used for the separation and concentration of heavy ore minerals which include ... | 0 | Metallurgy |
The mappae clavicula is a medieval Latin text containing manufacturing recipes for crafts materials, including for metals, glass, mosaics, and dyes and tints for materials. The information and style in the recipes is very terse. Each recipe consists of the names of the ingredients and typically about two sentences on c... | 0 | Metallurgy |
Discontinuous recrystallization is heterogeneous; there are distinct nucleation and growth stages. It is common in materials with low stacking-fault energy. Nucleation then occurs, generating new strain-free grains which absorb the pre-existing strained grains. It occurs more easily at grain boundaries, decreasing the ... | 0 | Metallurgy |
The lacUV5 promoter is a mutated promoter from the Escherichia coli lac operon which is used in molecular biology to drive gene expression on a plasmid. lacUV5 is very similar to the classical lac promoter, containing just 2 base pair mutations in the -10 hexamer region, compared to the lac promoter. LacUV5 is among th... | 1 | Gene expression + Signal Transduction |
Thermomechanical processing is a metallurgical process that combines mechanical or plastic deformation process like compression or forging, rolling, etc. with thermal processes like heat-treatment, water quenching, heating and cooling at various rates into a single process. | 0 | Metallurgy |
Everolimus is the second novel Rapamycin analog. Compared with the parent compound rapamycin, everolimus is more selective for the mTORC1 protein complex, with little impact on the mTORC2 complex. mTORC1 inhibition by everolimus has been shown to normalize tumor blood vessels, to increase tumor-infiltrating lymphocytes... | 1 | Gene expression + Signal Transduction |
Karl A. Smith is a metallurgical engineer, academic and author. He is an emeritus Cooperative Learning Professor of Engineering Education at Purdue University's School of Engineering Education, as well as an emeritus Professor of Civil, Environmental, and Geo-Engineering, Morse-Alumni Distinguished University Teaching ... | 0 | Metallurgy |
As mentioned above, G-proteins may terminate their own activation due to their intrinsic GTP→GDP hydrolysis capability. However, this reaction proceeds at a slow rate (≈0.02 times/sec) and, thus, it would take around 50 seconds for any single G-protein to deactivate if other factors did not come into play. Indeed, ther... | 1 | Gene expression + Signal Transduction |
SH2 domains, and other binding domains, have been used in protein engineering to create protein assemblies. Protein assemblies are formed when several proteins bind to one another to create a larger structure (called a supramolecular assembly). Using molecular biology techniques, fusion proteins of specific enzymes and... | 1 | Gene expression + Signal Transduction |
Calthemite coralloids (also known as popcorn), can form on the underside of concrete structures and look very similar to those which occurs in caves. Coralloids can form by a number of different methods in caves, however on concrete the most common form is created when hyperalkaline solution seeps from fine cracks in c... | 0 | Metallurgy |
The RNA-editing system seen in the animal may have evolved from mononucleotide deaminases, which have led to larger gene families that include the apobec-1 and adar genes. These genes share close identity with the bacterial deaminases involved in nucleotide metabolism. The adenosine deaminase of E. coli cannot deaminat... | 1 | Gene expression + Signal Transduction |
Zinc smelting is the process of converting zinc concentrates (ores that contain zinc) into pure zinc. Zinc smelting has historically been more difficult than the smelting of other metals, e.g. iron, because in contrast, zinc has a low boiling point. At temperatures typically used for smelting metals, zinc is a gas tha... | 0 | Metallurgy |
Downregulation of protein kinase A occurs by a feedback mechanism and uses a number of cAMP hydrolyzing phosphodiesterase (PDE) enzymes, which belong to the substrates activated by PKA. Phosphodiesterase quickly converts cAMP to AMP, thus reducing the amount of cAMP that can activate protein kinase A. PKA is also regul... | 1 | Gene expression + Signal Transduction |
Pharmacologic down-regulation of (mTOR) pathway during chemotherapy in a mouse model prevents activation of primordial follicles, preserves ovarian function, and maintains normal fertility using clinically available inhibitors INK and RAD. In that way, it helps to maintain fertility while undergoing chemotherapy treatm... | 1 | Gene expression + Signal Transduction |
A Lot (formerly Loth) was an old unit of measurement for the relative fineness to gross weight in metallurgy and especially in coinage until the 19th century. A Lot was thus a proportion of the precious metal content in a piece of metal. It was used in the four main monetary systems of Germany: Austrian, South German, ... | 0 | Metallurgy |
In cardiac muscle, β-catenin forms a complex with N-cadherin at adherens junctions within intercalated disc structures, which are responsible for electrical and mechanical coupling of adjacent cardiac cells. Studies in a model of adult rat ventricular cardiomyocytes have shown that the appearance and distribution of β-... | 1 | Gene expression + Signal Transduction |
Like the major spliceosome, the minor spliceosome had an early origin: several of its characteristic constituents are present in representative organisms from all eukaryotic supergroups for which there is any substantial genome sequence information. In addition, functionally important sequence elements contained within... | 1 | Gene expression + Signal Transduction |
Methanosaeta harundinacea 6Ac, a methanogenic archaeon, produces carboxylated acyl homoserine lactone compounds that facilitate the transition from growth as short cells to growth as filaments. | 1 | Gene expression + Signal Transduction |
The V Brigade uncovered peculiarities in metal composition during the Palaeo-Metallic epoch at the Allyn-Depe settlement.
The VII Brigade, carried out by Kuftin, was of the Namazgadepe explorations, which revealed six phases, sequentially deposited, and referred to as Namazga I to VI. It established the Chalcolithic (E... | 0 | Metallurgy |
The alloys of tantalum–tungsten have high corrosion resistance, and refractory properties. The crystalline structure of the material is body-centered cubic with a substitutional solid solution with atoms of tungsten. The alloy also has a high melting point and can reach high elastic modulus and high tensile strength. | 0 | Metallurgy |
To obtain the desired measurement of , it is not sufficient to just measure .
The temperature at the reference junctions must be already known.
Two strategies are often used here:
* "Ice bath" method: The reference junction block is immersed in a semi-frozen bath of distilled water at atmospheric pressure. The precise... | 0 | Metallurgy |
Rust is a general name for a complex of oxides and hydroxides of iron, which occur when iron or some alloys that contain iron are exposed to oxygen and moisture for a long period of time. Over time, the oxygen combines with the metal, forming new compounds collectively called rust, in a process called rusting. Rusting... | 0 | Metallurgy |
Members of the HNF4 subfamily are nuclear receptors and bind to DNA either as homodimers or RXR heterodimers.
* HNF4α/TCF14/MODY1
* HNF4γ | 1 | Gene expression + Signal Transduction |
Screening falls under two general categories: dry screening, and wet screening. From these categories, screening separates a flow of material into grades, these grades are then either further processed to an intermediary product or a finished product. Additionally, the machines can be categorized into a moving screen ... | 0 | Metallurgy |
The first step in failure analysis is investigating the failure to collect information. The sequence of steps for information gathering in a failure investigation are:
# Collection information about the circumstances surrounding the failure and selection of specimens
# Preliminary examination of the failed part (visual... | 0 | Metallurgy |
In April 1918, after the attack of German-Austrian troops, most of the equipment and materials of the Yuzovsky plant were evacuated to Tsaritsyn (Volgograd), and detachments of workers retreated with the Red Army.
On May 24, 1918, the plant was nationalized.
In May 1918, during the German occupation, an underground org... | 0 | Metallurgy |
EGF; LDLR; LRP1; LRP10; LRP1B; LRP2; LRP4; LRP5;
LRP5L; LRP6; LRP8; NID1; NID2; SORL1; VLDLR; | 1 | Gene expression + Signal Transduction |
CeCoIn is a member of a rich family of heavy-fermion compounds. CeIn is heavy-fermion metal with cubic crystal structure that orders antiferromagnetically below 10K. With applying external pressure, antiferromagnetism in CeIn is continuously suppressed, and a superconducting dome emerges in the phase diagram near the a... | 0 | Metallurgy |
The MyD88-dependent response occurs on dimerization of TLRs, and is used by every TLR except TLR3. Its primary effect is activation of NFκB and Mitogen-activated protein kinase. Ligand binding and conformational change that occurs in the receptor recruits the adaptor protein MyD88, a member of the TIR family. MyD88 the... | 1 | Gene expression + Signal Transduction |
The Ellingham curve for the reaction 2C(s) + (g) → 2CO(g) slopes down and falls below the curves for all the metals. Hence, carbon can normally act as a reducing agent for all metal oxides at very high temperatures. But chromium formed at these temperatures reacts with carbon to form its carbide, which gives undesirab... | 0 | Metallurgy |
Silicon carbide exists in about 250 crystalline forms. Through inert atmospheric pyrolysis of preceramic polymers, silicon carbide in a glassy amorphous form is also produced. The polymorphism of SiC is characterized by a large family of similar crystalline structures called polytypes. They are variations of the same c... | 0 | Metallurgy |
De re metallica (Latin for On the Nature of Metals [Minerals]) is a book in Latin cataloguing the state of the art of mining, refining, and smelting metals, published a year posthumously in 1556 due to a delay in preparing woodcuts for the text. The author was Georg Bauer, whose pen name was the Latinized Georgius Agri... | 0 | Metallurgy |
William H. Peirce (died 1944) was an American civil engineer and metallurgist, who pioneered copper production in the early 20th century. Among his achievements was the , invented with Elias Anton Cappelen Smith. | 0 | Metallurgy |
5-Methylcytosine (5-mC) is a methylated form of the DNA base cytosine (see figure). 5-mC is an epigenetic marker found predominantly on cytosines within CpG dinucleotides, which consist of a cytosine is followed by a guanine reading in the 5′ to 3′ direction along the DNA strand (CpG sites). About 28 million CpG din... | 1 | Gene expression + Signal Transduction |
The surface of a metallographic specimen is prepared by various methods of grinding, polishing, and etching. After preparation, it is often analyzed using optical or electron microscopy. Using only metallographic techniques, a skilled technician can identify alloys and predict material properties.
Mechanical preparatio... | 0 | Metallurgy |
The mechanisms of embrittlement are similar to those of metals. Inorganic glass embrittlement can be manifested via static fatigue. Embrittlement in glasses, such as Pyrex, is a function of humidity. Growth rate of cracks vary linearly with humidity, suggesting a first-order kinetic relationship. The static fatigue of ... | 0 | Metallurgy |
MCT2 transporters within the peroxisome function to transport pyruvate into the peroxisome where it is reduced by peroxisomal LDH (pLDH) to lactate. In turn, NADH is converted to NAD+, regenerating this necessary component for subsequent β-oxidation. Lactate is then shuttled out of the peroxisome via MCT2, where it is... | 1 | Gene expression + Signal Transduction |
One simplified example of a synexpression group is the genes cdc6, cdc3, cdc46, and swi4 in yeast, which are all co-expressed early in the G-1 stage of the cell cycle., These genes share one common cis-regulatory element, called ECB, which serves as a binding site for the MCM1 trans-acting protein. Although these gene... | 1 | Gene expression + Signal Transduction |
The lactate shuttle hypothesis also explains the balance of lactate production in the cytosol, via glycolysis or glycogenolysis, and lactate oxidation in the mitochondria (described below). | 1 | Gene expression + Signal Transduction |
Puddling is the process of converting pig iron to bar (wrought) iron in a coal fired reverberatory furnace. It was developed in England during the 1780s. The molten pig iron was stirred in a reverberatory furnace, in an oxidizing environment to burn the carbon, resulting in wrought iron. It was one of the most import... | 0 | Metallurgy |
Iron or steel, when heated to above 460 °C (900 °F), glows with a red color. The color of heated iron changes predictably (due to black-body radiation) from dull red through orange and yellow to white, and can be a useful indicator of its temperature. Good quality iron or steel at and above this temperature becomes inc... | 0 | Metallurgy |
Froth flotation is achieved by mixing chemicals known as collectors with the ore slurry. The collectors adsorb onto the surfaces of the particles of select minerals (usually the valuable mineral that is targeted for concentration), making these minerals hydrophobic. Air is passed through the slurry in a tank known as a... | 0 | Metallurgy |
The three related TET genes, TET1, TET2 and TET3 code respectively for three related mammalian proteins TET1, TET2, and TET3. All three proteins possess 5mC oxidase activity, but they differ in terms of domain architecture. TET proteins are large (~180- to 230-kDa) multidomain enzymes. All TET proteins contain a con... | 1 | Gene expression + Signal Transduction |
mTOR promotes the protein synthesis required for synaptic plasticity. Studies in cell cultures and hippocampal slices indicate that mTOR inhibition reduces long-term potentiation. mTOR activation can protect against certain neurodegeneration associated with certain disease conditions. On the other hand, promotion of au... | 1 | Gene expression + Signal Transduction |
*Erosion corrosion
*Pitting corrosion Oxygen pitting
*Hydrogen embrittlement
*Hydrogen-induced cracking (ASM term)
*Corrosion embrittlement (ASM term)
*Hydrogen disintegration (NACE term)
*Hydrogen-assisted cracking (ASM term)
*Hydrogen blistering
*Corrosion | 0 | Metallurgy |
It had long been thought that the sigma factor obligatorily leaves the core enzyme once it has initiated transcription, allowing it to link to another core enzyme and initiate transcription at another site. Thus, the sigma factor would cycle from one core to another.
However, fluorescence resonance energy transfer was ... | 1 | Gene expression + Signal Transduction |
Bacterial initiation factor 1 associates with the 30S ribosomal subunit in the A site and prevents an aminoacyl-tRNA from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the 50S subunit from binding, stopping the formation of the 70S subunit. It also contains a β-domai... | 1 | Gene expression + Signal Transduction |
Because of the widespread use and importance of iron and steel products, the prevention or slowing of rust is the basis of major economic activities in a number of specialized technologies. A brief overview of methods is presented here; for detailed coverage, see the cross-referenced articles.
Rust is permeable to air ... | 0 | Metallurgy |
The formation of new blood capillaries is an important component of pathological tissue repair in response to ischemia. The angiogenic process is complex and involves endothelial cell (EC) movement and proliferation.
SFRP1 has been shown to have a role in new vascularization after an ischemic event and as a potent ang... | 1 | Gene expression + Signal Transduction |
The Ruhr Valley provided an excellent location for the German iron and steel industry because of the availability of raw materials, coal, transport, a skilled labor force, nearby markets, and an entrepreneurial spirit that led to the creation of many firms, often in close conjunction with coal mines. By 1850 the Ruhr h... | 0 | Metallurgy |
Signal transducing histidine kinases are the key elements in two-component signal transduction systems. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation, and CheA, which plays a central role in the chemotaxis system. Histidine kinases usually have an N-terminal ligand-binding domain ... | 1 | Gene expression + Signal Transduction |
β-Catenin also acts as a morphogen in later stages of embryonic development. Together with TGF-β, an important role of β-catenin is to induce a morphogenic change in epithelial cells. It induces them to abandon their tight adhesion and assume a more mobile and loosely associated mesenchymal phenotype. During this proce... | 1 | Gene expression + Signal Transduction |
Individual transmembrane adenylyl cyclase isoforms have been linked to numerous physiological functions. Soluble adenylyl cyclase (sAC, AC10) has a critical role in sperm motility. Adenylyl cyclase has been implicated in memory formation, functioning as a coincidence detector. | 1 | Gene expression + Signal Transduction |
In order to maintain the solution electroneutrality inside the pit populated by cations released by oxidation in the anodic zone (e.g., in case of steel), anions need to migrate inside the narrow pit. It is worth to notice that the electromobilities of thiosulfate () and chloride () anions are the highest after these ... | 0 | Metallurgy |
Ribosomal frameshifting, also known as translational frameshifting or translational recoding, is a biological phenomenon that occurs during translation that results in the production of multiple, unique proteins from a single mRNA. The process can be programmed by the nucleotide sequence of the mRNA and is sometimes af... | 1 | Gene expression + Signal Transduction |
There are several challenges associated with gene silencing therapies, including delivery and specificity for targeted cells. For instance, for treatment of neurodegenerative disorders, molecules for a prospective gene silencing therapy must be delivered to the brain. The blood–brain barrier makes it difficult to deliv... | 1 | Gene expression + Signal Transduction |
Scrap metal is delivered to a scrap bay, located next to the melt shop. Scrap generally comes in two main grades: shred (whitegoods, cars and other objects made of similar light-gauge steel) and heavy melt (large slabs and beams), along with some direct reduced iron (DRI) or pig iron for chemical balance. Some furnaces... | 0 | Metallurgy |
*Prastarika: metal trader
*Sulbhadhatusastra: science of metals
*panchaloha, sarva loha: the five base metals (tin, lead, iron, copper, silver) | 0 | Metallurgy |
Directing edits to correct mutated sequences was first proposed and demonstrated in 1995. This initial work used synthetic RNA antisense oligonucleotides complementary to a pre-mature stop codon mutation in a dystrophin sequence to activate A-to-I editing of the stop codon to a read through codon in a model xenopus ce... | 1 | Gene expression + Signal Transduction |
Dideoxynucleotides are used in sequencing. These nucleoside triphosphates possess a non-canonical sugar, dideoxyribose, which lacks the 3 hydroxyl group normally present in DNA and therefore cannot bond with the next base. The lack of the 3 hydroxyl group terminates the chain reaction as the DNA polymerases mistake it ... | 1 | Gene expression + Signal Transduction |
Lightning strike protection minimizes damage to buildings during lightning terminations. This is usually accomplished by providing multiple interconnected pathways of low electrical impedance to the ground.
Copper and its alloys are the most common materials used in residential lightning protections, however in industr... | 0 | Metallurgy |
In order for long-term potentiation (LTP) to occur, there must be stimulation of NMDA receptors, which causes AMPA receptors to be inserted postsynaptically. PI3K binds to AMPA receptors in a conserved region to orient the receptors in the membrane, specifically at the GluR subunit. PI3K activity increases in response ... | 1 | Gene expression + Signal Transduction |
In 1821, the German physicist Thomas Johann Seebeck discovered that a magnetic needle held near a circuit made up of two dissimilar metals got deflected when one of the dissimilar metal junctions was heated. At the time, Seebeck referred to this consequence as thermo-magnetism. The magnetic field he observed was later ... | 0 | Metallurgy |
During the development of B cells, the immunoglobulin gene undergoes sequences of rearrangements that lead to formation of the antibody repertoire. For example, in the lymphoid cell, a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. Here at this stag... | 1 | Gene expression + Signal Transduction |
The function of the active zone is to ensure that neurotransmitters can be reliably released in a specific location of a neuron and only released when the neuron fires an action potential.
As an action potential propagates down an axon it reaches the axon terminal called the presynaptic bouton. In the presynaptic bout... | 1 | Gene expression + Signal Transduction |
Historically, small muffle ovens were often used for a second firing of porcelain at a relatively low temperature to fix overglaze enamels; these tend to be called muffle kilns. The pigments for most enamel colours discoloured at the high temperatures required for the body and glaze of the porcelain. They were used f... | 0 | Metallurgy |
South American metal working seems to have developed in the Andean region of modern Peru, Bolivia, Ecuador, Chile, and Argentina with gold and native copper being hammered and shaped into intricate objects, particularly ornaments.
Recent finds date the earliest gold work to 2155–1936 BCE. and the earliest copper ... | 0 | Metallurgy |
The technique was developed in Wallonia in present-day Belgium during the Middle Ages. The Walloon method consisted of making pig iron in a blast furnace, followed by refining it in a finery forge. The process was devised in the Liège region, and spread into France and thence from the Pays de Bray to England before th... | 0 | Metallurgy |
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two c... | 1 | Gene expression + Signal Transduction |
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin archit... | 1 | Gene expression + Signal Transduction |
This category groups pages related to the spliceosome, which is a loose conglomerate of protein and RNA responsible for the correct splicing of mRNA. | 1 | Gene expression + Signal Transduction |
Transient liquid phase diffusion bonding (TLPDB) is a joining process that has been applied for bonding many metallic and ceramic systems which cannot be bonded by conventional fusion welding techniques. The bonding process produces joints with a uniform composition profile, tolerant of surface oxides and geometrical d... | 0 | Metallurgy |
Introns were first discovered in protein-coding genes of adenovirus, and were subsequently identified in genes encoding transfer RNA and ribosomal RNA genes. Introns are now known to occur within a wide variety of genes throughout organisms, bacteria, and viruses within all of the biological kingdoms.
The fact that gen... | 1 | Gene expression + Signal Transduction |
According to some serotonin was "named for its source (sero-) and ability to modify smooth muscle tone (tonin)" an effect that may be dependent (some controversy exists) upon serotonylation.
The term serotonylation was created in 2003 by Diego J. Walther and colleagues of the Max Planck Institute for Molecular Geneti... | 1 | Gene expression + Signal Transduction |
*Gamma (γ): This is the matrix phase. While Co-based superalloys are less-used commercially, alloying elements include C, Cr, W, Ni, Ti, Al, Ir, and Ta. As in stainless steels, Chromium is used (occasionally up to 20 wt.%) to improve resistance to oxidation and corrosion via the formation of a CrO passive layer, which ... | 0 | Metallurgy |
Von Stahel und Eysen (English: On Steel and Iron) is the first printed book on metallurgy, published in 1532 by several publishers: Kunegunde Hergot in Nuremberg, Melchior Sachs in Erfurt, and Peter Jordan in Mainz. It has been suggested that Hergot was probably the first to publish the text, as the material seems to c... | 0 | Metallurgy |
In response to these market changes Eric Duckworth initiated changes of policy. Fulmer sought to extend its services to include the full range from R&D and testing to small scale manufacture, to extend its area of expertise to cover a wider range of materials and to develop new markets. It sought to collaborate with o... | 0 | Metallurgy |
With the appearance of the first factories in the Urals and the establishment of production and economic relations between the authorities and the owners, pronounced features of a subsistence economy appeared: everything necessary to ensure production was prepared and carried out at the factories on their own. Mining f... | 0 | Metallurgy |
* Bacteria: The code is used in Entomoplasmatales and Mycoplasmatales (Bove et al. 1989). The situation in the Acholeplasmatales is unclear. Based on a study of ribosomal protein genes, it had been concluded that UGA does not code for tryptophan in plant-pathogenic mycoplasma-like organisms (MLO) and the Acholeplasma... | 1 | Gene expression + Signal Transduction |
Signaling Gateway Molecule Pages is a database containing "essential information on more than 8000 mammalian proteins (Mouse and Human) involved in cellular signaling."
The content of molecule pages is authored by invited experts and is peer-reviewed. The published pages are citable by digital object identifiers (DOIs)... | 1 | Gene expression + Signal Transduction |
Neural stem cells (NSCs) in the brain must find a balance between maintaining their multipotency by self renewing and proliferating as opposed to differentiating and becoming quiescent. The PI3K/AKT pathway is crucial in this decision making process. NSCs are able to sense and respond to changes in the brain or through... | 1 | Gene expression + Signal Transduction |
Various methods are used to prevent and protect against corrosion, such as cathodic protection, selection and injection of chemicals such as corrosion inhibitors or other ways to prevent corrosion. However, in order to see the results of these methods and how effective these measures are, corrosion monitoring should b... | 0 | Metallurgy |
In the phosphatidylinositol signal pathway, the extracellular signal molecule binds with the G-protein receptor (G) on the cell surface and activates phospholipase C, which is located on the plasma membrane. The lipase hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol 1,4,5-tr... | 1 | Gene expression + Signal Transduction |
Transfer RNA (tRNA) helps decode a messenger RNA sequence into a protein. They function at specific sites within the ribosome during translation (the process going from code to protein). Within the mRNA molecule we have three nucleotides in length codons. These codons all have a unique universal code which represents a... | 1 | Gene expression + Signal Transduction |
This book describes separating silver from copper or iron. This is achieved by adding large amounts of lead at a temperature just above the melting point of lead. The lead will liquate out with the silver. This process will need to be repeated several times. The lead and silver can be separated by cupellation. | 0 | Metallurgy |
George Warren Hammond (April 4, 1833 – January 6, 1908) was an American businessman. Camp Hammond, in Yarmouth, Maine, is named for him. He was also one of its architects. Built in , it was placed on the National Register of Historic Places in 1979.
Hammond was also co-owner of Forest Paper Company, which was the larg... | 0 | Metallurgy |
The retinoblastoma protein is involved in the growth and development of mammalian hair cells of the cochlea, and appears to be related to the cells' inability to regenerate. Embryonic hair cells require pRb, among other important proteins, to exit the cell-cycle and stop dividing, which allows maturation of the auditor... | 1 | Gene expression + Signal Transduction |
The next major change in shutter hardware coincided with the American Civil War era. Heavy presses and punches were in use in factories around the country and a maturing rail transportation system opened inland areas for the products of the factories. Iron was the norm up until that time – steel had been expensive to p... | 0 | Metallurgy |
The first iron-cased and metal-cylinder rockets (Mysorean rockets) were developed by the Mysorean army of the South Indian Kingdom of Mysore in the 1780s. The Mysoreans successfully used these iron-cased rockets against the Presidency armies of the East India Company during the Anglo-Mysore Wars. | 0 | Metallurgy |
By using the S&S algorithm, mutations and genes that cause many different forms of cancer have been discovered. For example, genes causing commonly occurring cancers including breast cancer, ovarian cancer, colorectal cancer, leukemia, head and neck cancers, prostate cancer, retinoblastoma, squamous cell carcinoma, gas... | 1 | Gene expression + Signal Transduction |
The first time that A15 structure was observed was in 1931 when an electrolytically deposited layer of tungsten was examined. Discussion of whether the β-tungsten structure is an allotrope of tungsten or the structure of a tungsten suboxide was long-standing, but since the 1950s there has been many publications showin... | 0 | Metallurgy |
There are numerous cell signalling pathways that exhibit cross-talk with the PI3K pathway, potentially allowing cancer cells to escape inhibition of PI3K. As such, inhibition of the PI3K pathway alongside other targets could offer a synergistic response, such as that seen with PI3K and MEK co-targeted inhibition in lun... | 1 | Gene expression + Signal Transduction |
NANOG is highly expressed in cancer stem cells and may thus function as an oncogene to promote carcinogenesis. High expression of NANOG correlates with poor survival in cancer patients.
Recent research has shown that the localization of NANOG and other transcription factors have potential consequences on cellular funct... | 1 | Gene expression + Signal Transduction |
;Chemical shrinkage (self-desiccation)
The cement hydration process consumes water molecules. The sum of the volumes of the hydration products present in the hardened cement paste is smaller than the sum of the volumes of the reacting mineral phases present in the cement clinker. Therefore, the volume of the fresh and ... | 0 | Metallurgy |
Usually, a set of individually designed oligonucleotides is made on automated solid-phase synthesizers, purified and then connected by specific annealing and standard ligation or polymerase reactions. To improve specificity of oligonucleotide annealing, the synthesis step relies on a set of thermostable DNA ligase and ... | 1 | Gene expression + Signal Transduction |
The docking of IP to its receptor, which is called the inositol trisphosphate receptor (InsP3R), was first studied using deletion mutagenesis in the early 1990s. Studies focused on the N-terminus side of the IP receptor. In 1997 researchers localized the region of the IP receptor involved with binding of IP to between ... | 1 | Gene expression + Signal Transduction |
From the medieval period, an indirect process began to replace the direct reduction in bloomeries. This used a blast furnace to make pig iron, which then had to undergo a further process to make forgeable bar iron. Processes for the second stage include fining in a finery forge. In the 13th century during the High Mid... | 0 | Metallurgy |
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